title: A review on the therapeutic potential of embryonic and induced pluripotent stem cells in hepatic repair.
abstract: Despite the liver being proliferatively quiescent, it maintains balance between cell gain and cell loss, invokes a rapid regenerative response following hepatocyte loss, and restores liver mass. Human liver has immense regenerative capacity. Liver comprises many cell types with specialized functions. Of these cell types, hepatocytes play several key roles, but are most vulnerable to damage. Recent studies suggest that the extrahepatic stem cell pool contributes to liver regeneration. Stem cell therapies have the potential to enhance hepatic regeneration. Both embryonic and induced pluripotent stem cells could be a suitable source to regenerate hepatocytes. In the present review, we discuss the therapeutic potential of stem cells in hepatic repair and focus on the clinical applications of stem cells.
authors.affiliation: Department of Biotechnology, Acharya Nagarjuna University, Guntur, India.
authors.forename: K Ananda
authors.initials: KA
authors.lastname: Krishna
authors.forename: K Sai
authors.initials: KS
authors.lastname: Krishna
authors.forename: Ruben
authors.initials: R
authors.lastname: Berrocal
authors.forename: Alekya
authors.initials: A
authors.lastname: Tummala
authors.forename: K S
authors.initials: KS
authors.lastname: Rao
authors.forename: K R S Sambasiva
authors.initials: KR
authors.lastname: Rao