title: [Formulation aspects and ex-vivo examination of buccal drug delivery systems].
abstract: Application of buccal dosage forms has several advantages. Buccal route can be used for systemic delivery because the mucosa has a rich blood supply and it is relatively permeable. This route of drug delivery is of special advantages, including the bypass of first pass effect and the avoidance of presystemic elimination within the GIT. Buccal delivery systems enable the systemic delivery of peptides and proteins. In our previous study the physiological background of this application and the excipients of the possible formulations were reviewed. In the present work the formulation and ex vivo examination aspects of buccal drug delivery systems are summarized.
authors.affiliation: Semmelweis Egyetem, Egyetemi Gyógyszertár Gyögyszerügyi Szervezési Intézet Budapest, Hogyes E. u. 7-9. 1092.
authors.forename: Barnabás
authors.initials: B
authors.lastname: Szabó
authors.forename: Gergely
authors.initials: G
authors.lastname: Hetényi
authors.forename: Klaudia
authors.initials: K
authors.lastname: Majoros
authors.forename: Veronika
authors.initials: V
authors.lastname: Miszori
authors.forename: Nikolett
authors.initials: N
authors.lastname: Kállai
authors.forename: Romána
authors.initials: R
authors.lastname: Zelkó
mesh_terms: D000278:Administration, Buccal; D002199:Capillary Permeability; D002626:Chemistry, Pharmaceutical; D016503:Drug Delivery Systems; D006801:Humans; D009061:Mouth Mucosa / Q000378:metabolism