title: Impact of pretreatment body mass index on patients with head-and-neck cancer treated with radiation.
abstract: OBJECTIVE
  To investigate the association of pretreatment body mass index (preT BMI) with outcomes of head-and-neck cancer in patients treated with radiotherapy (RT).
  
  
  METHODS
  All 1,562 patients diagnosed with head-and-neck cancer and treated with curative-intent RT to a dose of 60 Gy or higher were retrospectively studied. Body weight was measured both at entry and at the end of RT. Cancer-specific survival (CSS), overall survival (OS), locoregional control (LRC), and distant metastasis (DM) were analyzed by preT BMI (<25 kg/m(2) vs. ≥25 kg/m(2)). The median follow-up was 8.6 years.
  
  
  RESULTS
  Patients with lower preT BMI were statistically significantly associated with poorer CSS and OS than those with higher preT BMI. There was no significant difference between preT BMI groups in terms of LRC and DM. Body weight loss (BWL) during radiation did not influence survival outcomes. However, in the group with higher preT BMI, CSS, OS, and DM-free survival of patients with less BWL during radiation were statistically longer when compared with greater BWL.
  
  
  CONCLUSIONS
  This study demonstrates that higher preT BMI positively influenced survival outcomes for patients with head-and-neck cancer. Patients with higher preT BMI who were able to maintain their weight during radiation had significantly better survival than patients with greater BWL.
authors.affiliation: Department of Radiation Oncology, Chang Gung Memorial Hospital and University at Lin-Kou, Taoyuan, Taiwan.
authors.forename: Ping-Ching
authors.initials: PC
authors.lastname: Pai
authors.forename: Chi-Cheng
authors.initials: CC
authors.lastname: Chuang
authors.forename: Chen-Kan
authors.initials: CK
authors.lastname: Tseng
authors.forename: Ngan-Ming
authors.initials: NM
authors.lastname: Tsang
authors.forename: Kai-Ping
authors.initials: KP
authors.lastname: Chang
authors.forename: Tzu-Chen
authors.initials: TC
authors.lastname: Yen
authors.forename: Chun-Ta
authors.initials: CT
authors.lastname: Liao
authors.forename: Ji-Hong
authors.initials: JH
authors.lastname: Hong
authors.forename: Joseph Tung-Chieh
authors.initials: JT
authors.lastname: Chang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D004522:Educational Status; D005260:Female; D006258:Head and Neck Neoplasms / Q000401:mortality* / Q000503:physiopathology / Q000532:radiotherapy*; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000401:mortality / Q000503:physiopathology / Q000532:radiotherapy; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000503:physiopathology / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000401:mortality / Q000503:physiopathology / Q000532:radiotherapy; D009752:Nutritional Status / Q000502:physiology*; D009765:Obesity / Q000401:mortality; D009959:Oropharyngeal Neoplasms / Q000401:mortality / Q000503:physiopathology / Q000532:radiotherapy; D011379:Prognosis; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D016019:Survival Analysis; D013624:Taiwan; D013851:Thinness / Q000401:mortality; D015431:Weight Loss; D055815:Young Adult