title: Removal of malaria-infected red blood cells using magnetic cell separators: A computational study.
abstract: High gradient magnetic field separators have been widely used in a variety of biological applications. Recently, the use of magnetic separators to remove malaria-infected red blood cells (pRBCs) from blood circulation in patients with severe malaria has been proposed in a dialysis-like treatment. The capture efficiency of this process depends on many interrelated design variables and constraints such as magnetic pole array pitch, chamber height, and flow rate. In this paper, we model the malaria-infected RBCs (pRBCs) as paramagnetic particles suspended in a Newtonian fluid. Trajectories of the infected cells are numerically calculated inside a micro-channel exposed to a periodic magnetic field gradient. First-order stiff ordinary differential equations (ODEs) governing the trajectory of particles under periodic magnetic fields due to an array of wires are solved numerically using the 1(st) -5(th) order adaptive step Runge-Kutta solver. The numerical experiments show that in order to achieve a capture efficiency of 99% for the pRBCs it is required to have a longer length than 80 mm; this implies that in principle, using optimization techniques the length could be adjusted, i.e., shortened to achieve 99% capture efficiency of the pRBCs.
authors.affiliation: Department of Biomedical Engineering, Carnegie Mellon University, Pittsburgh, PA, 15213 USA.
authors.forename: Jeongho
authors.initials: J
authors.lastname: Kim
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Massoudi
authors.forename: James F
authors.initials: JF
authors.lastname: Antaki
authors.forename: Alberto
authors.initials: A
authors.lastname: Gandini