title: [The relationships between the peak inspiratory flow and the characteristics factors in the asthmatics with inhaled corticosteroid -a multicenter study in Chugoku Shikoku area].
abstract: BACKGROUND
  Inhaled corticosteroid (ICS) will be effective if used properly. Inadequate intake may result in insufficiency, such as for elderly asthmatics, in particular, for use of dry powder inhalers.
  
  
  METHODS
  312 asthmatics treated with ICS for at least 6 months in the 6 facilities belonging to the Chugoku Shikoku Adult Asthma Research Forum were subject to investigation of the peak inspiratory flow (PIF) measured using In-check® and related factors.
  
  
  RESULTS
  Nine (2.8%) patients were considered to have insufficient intake. By multivariate analysis, PIF (L/min) prediction formula was as follows: 79.0+0.19* peak expiratory flow (PEF: L/min)+22.9* FVC (L)-0.68* onset age (years)+34.7* gender (male, 1; female, 0)+16.1* V50/V25, [r^2=0.677, p<0.0001]. Using cluster analysis with Euclidean distance and Ward's method, the PIF without an adaptor was included in the same category as height and PEF, and the PIF with an adaptor was included in the same category as %FVC and %FEV1.0.
  
  
  CONCLUSIONS
  The cases with insufficient PIF are few but present. Adequate device selection and inhalation guidance may be important. The meaning of PIF differs depending on whether or not an adaptor is present. Further investigation of intake is considered necessary.
authors.affiliation: Department of Respiratory Medicine, Kawasaki Medical School. obaseya@med.kawasaki-m.ac.jp
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Obase
authors.forename: Arihiko
authors.initials: A
authors.lastname: Kanehiro
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Tanimoto
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Miyahara
authors.forename: Mikio
authors.initials: M
authors.lastname: Oka
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Eda
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kubota
authors.forename: Akihito
authors.initials: A
authors.lastname: Yokoyama
authors.forename: Kiryo
authors.initials: K
authors.lastname: Wakabayashi
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Takeyama
authors.forename: Chiharu
authors.initials: C
authors.lastname: Okada
authors.forename: Goro
authors.initials: G
authors.lastname: Kimura
authors.forename: Ryo
authors.initials: R
authors.lastname: Soda
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Takahashi
authors.forename: Mitsune
authors.initials: M
authors.lastname: Tanimoto
mesh_terms: D000280:Administration, Inhalation; D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007320:Inspiratory Capacity / Q000502:physiology*; D008297:Male; D036501:Metered Dose Inhalers; D008875:Middle Aged
chemical_list: D000305:Adrenal Cortex Hormones