title: Coordinating tissue interactions: Notch signaling in cardiac development and disease.
abstract: The Notch pathway is a crucial cell-fate regulator in the developing heart. Attention in the past centered on Notch function in cardiomyocytes. However, recent advances demonstrate that region-specific endocardial Notch activity orchestrates the patterning and morphogenesis of cardiac chambers and valves through regulatory interaction with multiple myocardial and neural crest signals. Notch also regulates cardiomyocyte proliferation and differentiation during ventricular chamber development and is required for coronary vessel specification. Here, we review these data and highlight disease connections, including evidence that Notch-Hey-Bmp2 interplay impacts adult heart valve disease and that Notch contributes to cardiac arrhythmia and pre-excitation syndromes.
authors.affiliation: Program of Cardiovascular Developmental Biology, Department of Cardiovascular Development and Repair, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Melchor Fernández Almagro 3, E-28029 Madrid, Spain. jlpompa@cnic.es
authors.forename: José Luis
authors.initials: JL
authors.lastname: de la Pompa
authors.forename: Jonathan A
authors.initials: JA
authors.lastname: Epstein
mesh_terms: D000328:Adult; D018507:Gene Expression Regulation, Developmental; D006331:Heart Diseases / Q000378:metabolism* / Q000473:pathology*; D006351:Heart Valves / Q000196:embryology* / Q000473:pathology*; D006801:Humans; D051880:Receptors, Notch / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D051880:Receptors, Notch