title: Gas-flow assisted ion transfer for mass spectrometry.
abstract: Methods and devices that use gas flows to collect ions and transfer them over long distances for mass spectrometric analysis have been developed. Gas flows derived from the ionization source itself or provided by means of additional pumping were used to generate a laminar flow inside cylindrical tube. Hydrodynamic simulations and experimental tests demonstrate that laminar flow can transfer ions over long distance. The typical angular discrimination effects encountered when sampling ions from ambient ionization sources are minimized, and the sampling of relatively large surface areas is demonstrated with desorption electrospray ionization (DESI). Ion transfer over 6 m has been achieved and its application to multiplexed chemical analysis is demonstrated on samples at locations remote from the mass spectrometer.
authors.affiliation: Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.
authors.forename: Sandilya
authors.initials: S
authors.lastname: Garimella
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
authors.forename: Guangming
authors.initials: G
authors.lastname: Huang
authors.forename: Jason D
authors.initials: JD
authors.lastname: Harper
authors.forename: R Graham
authors.initials: RG
authors.lastname: Cooks
authors.forename: Zheng
authors.initials: Z
authors.lastname: Ouyang
mesh_terms: D001274:Atmospheric Pressure; D003198:Computer Simulation; D004867:Equipment Design; D005740:Gases / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000032:analysis; D021241:Spectrometry, Mass, Electrospray Ionization / Q000295:instrumentation* / Q000379:methods
chemical_list: D005740:Gases; D004364:Pharmaceutical Preparations