title: VEGF-D(ilated) lymphatics as gateways to metastasis.
abstract: VEGF-C and VEGF-D have been implicated in lymphatic metastasis, mainly as inducers of new intra/peritumoral capillary lymphatics. In this issue of Cancer Cell, Karnezis and colleagues challenge this notion and demonstrate that tumor-derived VEGF-D promotes metastasis by causing prostaglandin-dependent dilation of collecting lymphatics outside of the tumor mass.
authors.affiliation: Montreal Children's Hospital The Research Institute--McGill University Health Centre, 4060 Ste Catherine West, Montreal, QC, H3Z 3Z2, Canada. janusz.rak@mcgill.ca
authors.forename: Janusz
authors.initials: J
authors.lastname: Rak