title: Cyclo-(His,Leu): a new microbial diketopiperazine from a terrestrial Bacillus subtilis strain B38.
abstract: In continuation of our search for bioactive secondary metabolites from terrestrial Bacillus spp., a new microbial diketopiperazine, cis-cyclo-(His,Leu) (1) was isolated from the ethyl acetate extract of a strain B. subtilis B38, together with cis-cyclo-(Phe,Phe) (2), tryptophane (3), cis-cyclo-(Leu,Tyr) (4), cis-cyclo-(Trp,Tyr) (5) and macrolactin A (6). The chemical structures of the isolated compounds were identified by comparison of their 1D, 2D NMR and HRESIMS data with authentic spectra and literatures. To the best of our knowledge, this is the first time that cyclo-(His,Leu) has been isolated from natural products.
authors.affiliation: Laboratoire des Substances Bioactives, Centre de Biotechnologie de Borj-Cedria, BP 901, Hammam-Lif 2050, Tunisia. elkahoui@yahoo.fr
authors.forename: Salem
authors.initials: S
authors.lastname: Elkahoui
authors.forename: Hamdi
authors.initials: H
authors.lastname: Abdel rahim
authors.forename: Olfa
authors.initials: O
authors.lastname: Tabbene
authors.forename: Mohamed
authors.initials: M
authors.lastname: Shaaban
authors.forename: Ferid
authors.initials: F
authors.lastname: Limam
authors.forename: Hartmut
authors.initials: H
authors.lastname: Laatsch
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000737:chemistry*; D054659:Diketopiperazines / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000032:analysis* / Q000302:isolation & purification / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000890:Anti-Infective Agents; D054659:Diketopiperazines; D010456:Peptides, Cyclic