title: An unusual case of an acute hemolytic transfusion reaction caused by an autoanti-I.
abstract: In general, naturally occurring cold autoagglutinins react optimally at low temperatures. We describe a young child who experienced an acute hemolytic transfusion reaction by an unusual autoanti-I. The IgM autoanti-I was detected at 4°C (titer 256) and also reacted at 30°C. This case highlights the potential hazard of transfusing units of blood immediately upon removal from the blood refrigerator, especially into neonates and children of small stature.
authors.affiliation: Red Cell Immunohaematology, NHSBT-Tooting Centre, 75, Cranmer Terrace, Tooting, United Kingdom SW17 0RB.
authors.forename: Nay
authors.initials: N
authors.lastname: Win
authors.forename: Malcolm
authors.initials: M
authors.lastname: Needs
authors.forename: Sally
authors.initials: S
authors.lastname: Rahman
authors.forename: Philip
authors.initials: P
authors.lastname: Gold
authors.forename: Susan
authors.initials: S
authors.lastname: Ward
mesh_terms: D000208:Acute Disease; D000744:Anemia, Hemolytic, Autoimmune / Q000097:blood* / Q000276:immunology*; D001323:Autoantibodies / Q000009:adverse effects / Q000097:blood*; D001787:Blood Group Incompatibility / Q000097:blood* / Q000150:complications; D001788:Blood Grouping and Crossmatching; D002478:Cells, Cultured; D002648:Child; D003080:Cold Temperature / Q000009:adverse effects*; D005189:False Positive Reactions; D017408:Guidelines as Topic; D006801:Humans; D007048:I Blood-Group System / Q000276:immunology*; D008297:Male; D011485:Protein Binding; D015203:Reproducibility of Results
chemical_list: D001323:Autoantibodies; D007048:I Blood-Group System