title: [Application of endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis of isolated mediastinal lesions].
abstract: OBJECTIVE
  To evaluate the role of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in the diagnosis of isolated mediastinal lesions.
  
  
  METHODS
  A retrospective study was conducted of 73 consecutive patients with isolated mediastinal lesions of unknown origin without parenchymal lung abnormalities, who underwent EBUS-TBNA from September 2009 to April 2011. The patients who were nondiagnostic with EBUS-TBNA subsequently underwent surgical biopsies and a minimum of 6 months'clinical and radiologic follow-up.
  
  
  RESULTS
  EBUS-TBNA achieved definitive diagnoses in 60 patients of the 73 patients (82.2%, 60/73). Malignancies were diagnosed in 23 patients and benignancies in 37. The sensitivity, specificity, and accuracy of EBUS-TBNA in distinguishing malignant mediastinal lesions were 95.8%(23/24), 100%(49/49) and 98.6%(72/73), respectively. EBUS was well tolerated by all of the patients with no complications.
  
  
  CONCLUSIONS
  EBUS-TBNA of isolated mediastinal lesions is a minimally invasive and safe diagnostic technique with high yield.
authors.affiliation: Department of Thoracic Surgery, Peking University People's Hospital, Beijing 100044, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhao
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.forename: Zu-li
authors.initials: ZL
authors.lastname: Zhou
authors.forename: Yun
authors.initials: Y
authors.lastname: Li
authors.forename: Liang
authors.initials: L
authors.lastname: Bu
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.forename: Xi-zhao
authors.initials: XZ
authors.lastname: Sui
authors.forename: Ke-zhong
authors.initials: KZ
authors.lastname: Chen
authors.forename: Xiao
authors.initials: X
authors.lastname: Li
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.forename: Jian-feng
authors.initials: JF
authors.lastname: Li
authors.forename: Guan-chao
authors.initials: GC
authors.lastname: Jiang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D044963:Biopsy, Fine-Needle / Q000379:methods*; D001980:Bronchi; D001999:Bronchoscopy; D019160:Endosonography; D005260:Female; D006801:Humans; D008297:Male; D008477:Mediastinal Diseases / Q000473:pathology*; D008479:Mediastinal Neoplasms / Q000473:pathology*; D008875:Middle Aged; D012189:Retrospective Studies; D018084:Ultrasonography, Interventional; D055815:Young Adult