title: [Expression and clinical significance of thymidine phosphorylase/platelet-derived endothelial cell growth factor in renal cell carcinoma].
abstract: OBJECTIVE
  To explore the expression and clinical significance of thymidine phosphorylase/platelet-derived endothelial cell growth factor (PD-ECGF) in renal cell carcinoma.
  
  
  METHODS
  The expression of PD-ECGF in 76 specimens of renal cell carcinoma from June 2002 to December 2006 was examined by EnVision immunohistochemistry. The correlation of the expression of PD-ECGF with the clinicopathological characteristics and prognosis in renal cell carcinoma patients were analyzed.
  
  
  RESULTS
  Among 76 renal cell carcinoma patients, 41 patients had a high-level expression of PD-ECGF while another 35 patients a low-level expression. The expression of PD-ECGF was positively correlated with tumor stage and histological grade. The 5-year overall survival rate was significant lower in the patients with a high-level expression of PD-ECGF (60.98% vs 94.29%, P = 0.000). Univariate analysis showed that the characteristics with the prognostic significance for survival were tumor stage, lymph node metastasis, distant metastasis, histological grade and the expression of PD-ECGF. Multivariate analysis showed that tumor stage, histological grade and the expression of PD-ECGF were independent prognostic factors (OR: 17.971, 9.702, 6.790, 95%CI: 3.010 - 107.290, 1.835 - 51.305, 1.156 - 39.894).
  
  
  CONCLUSIONS
  The expression of PD-ECGF may play an important role in the development and invasion of renal cell carcinoma. An elevated level of PD-ECGF is probably correlated with the prognosis of renal cell carcinoma.
authors.affiliation: Department of Urology, Affiliated Hospital of Xiangfan University, Xiangyang, China.
authors.forename: Xing
authors.initials: X
authors.lastname: Huang
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Hong-bo
authors.initials: HB
authors.lastname: Shi
authors.forename: Xue-jun
authors.initials: XJ
authors.lastname: Zhang
authors.forename: Xiao-wei
authors.initials: XW
authors.lastname: Men
authors.forename: Bin
authors.initials: B
authors.lastname: Chen
authors.forename: Xing-huan
authors.initials: XH
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D013939:Thymidine Phosphorylase / Q000235:genetics / Q000378:metabolism*
chemical_list: C543750:TYMP protein, human; D013939:Thymidine Phosphorylase