title: Equal HIV-1 decay kinetics in HSV-2-infected and HSV-2-uninfected clinical trial participants treated with antiretroviral therapy.
abstract: Herpes simplex virus-2 increases HIV-1 viral load and may augment HIV-1 transmission probability. To test the hypothesis that lower HIV-1 clearance rates in HSV-2-infected persons may account for this higher HIV-1 viral load, we studied 149 participants from 3 ACTG viral dynamic studies (A315, A5160s, and A5166s). Though HIV-1 viral load was 0.19 logs higher in HSV-2-positive versus HSV-2-negative persons, first and second phase clearance rates during antiretroviral therapy were equal between participants in these 2 groups.
authors.affiliation: Fred Hutchinson Cancer Research Center, Seattle, WA, USA. Jschoute@fhcrc.org
authors.forename: Jeffrey Thomas
authors.initials: JT
authors.lastname: Schouten
authors.forename: Joshua T
authors.initials: JT
authors.lastname: Schiffer
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage*; D023241:Antiretroviral Therapy, Highly Active; D060085:Coinfection / Q000188:drug therapy; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy* / Q000821:virology*; D015497:HIV-1 / Q000302:isolation & purification*; D006558:Herpes Genitalis / Q000150:complications*; D018258:Herpesvirus 2, Human / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D019562:Viral Load
chemical_list: D019380:Anti-HIV Agents