title: The regulatory role of long-term depression in juvenile and adult mouse ocular dominance plasticity.
abstract: The study of experience-dependent ocular dominance (OD) plasticity has greatly contributed to the understanding of visual development. During the critical period, preventing input from one eye results in a significant impairment of vision, and loss of cortical responsivity via the deprived eye. Residual ocular dominance plasticity has recently been observed in adulthood. Accumulating evidence suggests that OD plasticity involves N-methyl-(D)-aspartate receptor (NMDAR)-dependent long-term depression (LTD). Here we report that the administration of a selective LTD antagonist prevented the ocular dominance shift during the critical period. The NMDAR co-agonist D-serine facilitated adult visual cortical LTD and the OD shift in short-term monocularly deprived (MD) adult mice. When combined with reverse suture, D-serine proved effective in restoring a contralaterally-dominated visual input pattern in long-term MD mice. This work suggests LTD as a key mechanism in both juvenile and adult ocular dominance plasticity, and D-serine as a potential therapeutic in human amblyopic subjects.
authors.affiliation: Brain Research Centre, Vancouver Coastal Health Research Institute and University of British Columbia , Vancouver, BC, Canada V6T 2B5. kyyang@interchange.ubc.ca
authors.forename: Kaiyun
authors.initials: K
authors.lastname: Yang
authors.forename: Wei
authors.initials: W
authors.lastname: Xiong
authors.forename: Guang
authors.initials: G
authors.lastname: Yang
authors.forename: Luba
authors.initials: L
authors.lastname: Kojic
authors.forename: Changiz
authors.initials: C
authors.lastname: Taghibiglou
authors.forename: Yu Tian
authors.initials: YT
authors.lastname: Wang
authors.forename: Max
authors.initials: M
authors.lastname: Cynader
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism / Q000473:pathology; D023882:Dominance, Ocular; D004594:Electrophysiology / Q000379:methods; D036881:Long-Term Synaptic Depression; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009473:Neuronal Plasticity / Q000502:physiology; D010455:Peptides / Q000737:chemistry; D018091:Receptors, AMPA / Q000378:metabolism / Q000502:physiology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*; D012694:Serine / Q000737:chemistry; D013997:Time Factors; D014785:Vision, Ocular; D014795:Visual Pathways
chemical_list: D010455:Peptides; D018091:Receptors, AMPA; D016194:Receptors, N-Methyl-D-Aspartate; D012694:Serine; C104722:glutamate receptor ionotropic, AMPA 2