title: Imaging radiotherapy-induced apoptosis.
abstract: Prediction of response to therapy has been identified as an important tool to obtain a more customized treatment. It allows the selection of those patients who will benefit most from a particular therapy and prevents the exposure of patients to toxic, noneffective regimens. Recent technical advances and the introduction of novel markers in anatomical and functional imaging have created exciting opportunities for in vivo visualization and quantification of cell death. This review will focus on in vivo apoptosis imaging as a predictive marker for tumor response after radiation.
authors.affiliation: Department of Radiation Oncology, Memorial Sloan-Kettering Cancer Center, New York, New York 10065, USA. a-haimovitz-friedman@ski.mskcc.org
authors.forename: Adriana
authors.initials: A
authors.lastname: Haimovitz-Friedman
authors.forename: Tzu-I Jonathan
authors.initials: TJ
authors.lastname: Yang
authors.forename: Tin Htwe
authors.initials: TH
authors.lastname: Thin
authors.forename: Marcel
authors.initials: M
authors.lastname: Verheij
mesh_terms: D000818:Animals; D017304:Annexin A5; D017209:Apoptosis / Q000502:physiology / Q000528:radiation effects*; D053148:Caspase 3 / Q000502:physiology; D059248:Chemoradiotherapy; D002986:Clinical Trials as Topic; D003287:Contrast Media; D038524:Diffusion Magnetic Resonance Imaging; D016650:Fluorescein-5-isothiocyanate / Q000031:analogs & derivatives; D005456:Fluorescent Dyes; D006801:Humans; D051379:Mice; D045423:Microbubbles; D057054:Molecular Imaging / Q000379:methods*; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy*; D015609:Organotechnetium Compounds; D049268:Positron-Emission Tomography / Q000379:methods; D011832:Radiation Injuries / Q000209:etiology / Q000473:pathology; D019275:Radiopharmaceuticals; D011878:Radiotherapy / Q000009:adverse effects; D011879:Radiotherapy Dosage; D053218:Receptors, Death Domain / Q000502:physiology; D017256:Technetium Tc 99m Sestamibi; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods; D016896:Treatment Outcome; D014463:Ultrasonography / Q000379:methods
chemical_list: D017304:Annexin A5; D003287:Contrast Media; C492760:FITC-annexin A5; D005456:Fluorescent Dyes; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D053218:Receptors, Death Domain; C417036:technetium Tc 99m annexin V; D017256:Technetium Tc 99m Sestamibi; D053148:Caspase 3; D016650:Fluorescein-5-isothiocyanate