title: Infection by rhinovirus: similarity of clinical signs included in the case definition of influenza IAn/H1N1.
abstract: BACKGROUND
  Although new influenza virus (IAn/H1N1) infections are mild and indistinguishable from any other seasonal influenza virus infections, there are few data on comparisons of the clinical features of infection with (IAn/H1N1) and with other respiratory viruses. The incidence, clinical aspects and temporal distribution of those respiratory viruses circulating during flu pandemic period were studied.
  
  
  METHODS
  Respiratory samples from patients with acute influenza-like symptoms were collected from May 2009 to December 2009. Respiratory viruses were detected by conventional culture methods and genome amplification techniques.
  
  
  RESULTS
  Although IAn/H1N1 was the virus most frequently detected, several other respiratory viruses co-circulated with IAn/H1N1 during the pandemic period, especially rhinovirus. The similarity between clinical signs included in the clinical case definition for influenza and those caused by other respiratory viruses, particularly rhinovirus, suggest that a high percentage of viral infections were clinically diagnosed as case of influenza.
  
  
  CONCLUSIONS
  Our study offers useful information to face future pandemics caused by influenza virus, indicating that differential diagnoses are required in order to not overestimate the importance of the pandemic.
authors.affiliation: Servicio de Microbiología, Hospital Universitario Central de Asturias, Consejería de Sanidad y Servicios Sanitarios de Principado de Asturias, Oviedo, Spain.
authors.forename: Maria
authors.initials: M
authors.lastname: de Oña Navarro
authors.forename: Santiago
authors.initials: S
authors.lastname: Melón García
authors.forename: Marta
authors.initials: M
authors.lastname: Alvarez-Argüelles
authors.forename: Ana
authors.initials: A
authors.lastname: Fernández-Verdugo
authors.forename: Jose Antonio
authors.initials: JA
authors.lastname: Boga Riveiro
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D003139:Common Cold / Q000175:diagnosis* / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007223:Infant; D053118:Influenza A Virus, H1N1 Subtype; D007251:Influenza, Human / Q000175:diagnosis* / Q000453:epidemiology; D008875:Middle Aged; D012229:Rhinovirus; D012621:Seasons; D013030:Spain / Q000453:epidemiology; D055815:Young Adult