title: The signaling mechanism of ambient pH sensing and adaptation in yeast and fungi.
abstract: The four protein complexes termed endosomal sorting complexes required for transport (ESCRT) are key mediators of multivesicular body sorting/formation, retroviral budding and cell abscission, which share a membrane deformation process with the same topological change: vesicles budding away from the cytoplasm. Independent studies of the signal transduction pathways that mediate ambient pH sensing and adaptation in yeast and fungi revealed that these pathways share a conserved signaling mechanism that utilizes ESCRT complexes for its activation. This pathway in Saccharomyces cerevisiae, termed the Rim101 pathway, consists of both a sensing complex, which senses ambient alkaline pH, and a proteolytic complex, which proteolyzes and thereby activates the key transcription factor Rim101. Since the proteolytic complex is thought to be formed and activated on a platform of a multimerized ESCRT-III component Snf7, the organization, regulation and function of this pathway are dependent on the function of ESCRT complexes.
authors.affiliation: Institute of Molecular and Cellular Biosciences, University of Tokyo, Tokyo, Japan. maeda@iam.u-tokyo.ac.jp
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Maeda
mesh_terms: D000064:Acclimatization; D056827:Endosomal Sorting Complexes Required for Transport / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D012441:Saccharomyces cerevisiae / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D056827:Endosomal Sorting Complexes Required for Transport; D029701:Saccharomyces cerevisiae Proteins