title: Chemically programmed supramolecular assembly of hemoprotein and streptavidin with alternating alignment.
abstract: Alternating: a cofactor dyad consisting of a heme group (red in picture) and a bis(biotin) unit (blue) was synthesized and shown to specifically bind to both apomyoglobin and streptavidin. In the presence of the dyad, the 1:1 association of a disulfide-bridged myoglobin dimer (green) with streptavidin (gray) afforded a submicrometer-sized fibrous alternating copolymer.
authors.affiliation: Department of Applied Chemistry, Graduate School of Engineering, Osaka University, Suita, Japan.
authors.forename: Koji
authors.initials: K
authors.lastname: Oohora
authors.forename: Sabina
authors.initials: S
authors.lastname: Burazerovic
authors.forename: Akira
authors.initials: A
authors.lastname: Onoda
authors.forename: Yvonne M
authors.initials: YM
authors.lastname: Wilson
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Ward
authors.forename: Takashi
authors.initials: T
authors.lastname: Hayashi
mesh_terms: D001665:Binding Sites; D001710:Biotin / Q000737:chemistry / Q000378:metabolism; D006420:Hemeproteins / Q000737:chemistry* / Q000378:metabolism; D009211:Myoglobin / Q000737:chemistry / Q000378:metabolism; D019809:Streptavidin / Q000737:chemistry* / Q000378:metabolism
chemical_list: D006420:Hemeproteins; D009211:Myoglobin; D001710:Biotin; D019809:Streptavidin