title: Polymorphisms in 1-carbon metabolism, epigenetics and folate-related pathologies.
abstract: Folate-mediated 1-carbon metabolism is a network of interconnected metabolic pathways necessary for the synthesis of purine nucleotides, thymidylate and the remethylation of homocysteine to methionine. Disruptions in this pathway influence both DNA synthesis and stability and chromatin methylation, and result from nutritional deficiencies and common gene variants. The mechanisms underlying folate-associated pathologies and developmental anomalies have yet to be established. This review focuses on the relationships among folate-mediated 1-carbon metabolism, chromatin methylation and human disease, and the role of gene-nutrient interactions in modifying epigenetic processes.
authors.affiliation: Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA. PJS13@cornell.edu
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Stover
mesh_terms: D000483:Alleles; D000818:Animals; D002244:Carbon / Q000378:metabolism*; D002843:Chromatin / Q000737:chemistry / Q000378:metabolism; D019175:DNA Methylation; D015254:DNA Modification Methylases / Q000737:chemistry; D057890:Epigenomics; D005492:Folic Acid / Q000737:chemistry*; D014644:Genetic Variation; D006710:Homocysteine / Q000737:chemistry; D006801:Humans; D008928:Mitochondria / Q000378:metabolism; D008954:Models, Biological; D052756:Nutritional Sciences; D011110:Polymorphism, Genetic; D014803:Vitamin B Complex / Q000378:metabolism
chemical_list: D002843:Chromatin; D006710:Homocysteine; D014803:Vitamin B Complex; D002244:Carbon; D005492:Folic Acid; D015254:DNA Modification Methylases