title: Lymphocyte clones from old subjects: growing rate and functional activity.
abstract: Old subjects exhibit a decline in circulating T cells and an impaired proliferative response to mitogens, plus a relative increase in cells with NK phenotype not associated with a concomitant increase in their cytolitic activity.In the present study a limiting dilution assay was used to evaluate the phenotype, the functional activity and the proliferative capacity of clones obtained from peripheral blood lymphocytes of old and young subjects. CD5+ CD8+ clones from old people showed a significant impairment in their proliferative capacity and a decreased lytic activity against K562 and P815-IgG cell lines.
authors.affiliation: Istituti di: Clinica Medica e Gastroenterologia, Università di Bologna, Bologna, Italy.
authors.forename: E
authors.initials: E
authors.lastname: Mariani
authors.forename: P
authors.initials: P
authors.lastname: Roda
authors.forename: A R
authors.initials: AR
authors.lastname: Mariani
authors.forename: M
authors.initials: M
authors.lastname: Vitale
authors.forename: A
authors.initials: A
authors.lastname: Degrassi
authors.forename: S
authors.initials: S
authors.lastname: Papa
authors.forename: F A
authors.initials: FA
authors.lastname: Manzoli
authors.forename: A
authors.initials: A
authors.lastname: Facchini