title: Morphometric analysis of the brain vesicles during the human embryonic period by magnetic resonance microscopic imaging.
abstract: The development of the brain vesicles between Carnegie stages (CS) 17 and 23 was analyzed morphometrically using 177 magnetic resonance image data derived from the Kyoto Collection of Human Embryos. Whole embryonic volume was 106.55 ± 21.08 mm(3) at CS17, exponentially increasing to CS23 when it reached 1357.28 ± 392.20 mm(3). Length of brain vesicles was 29.83 ± 2.52 mm at CS17, increased almost linearly and reached 49.31 ± 6.66 mm at CS23. The rate of increase was approximately 4.2 times higher on the dorsal side than on the ventral side. The increase in the length of the brain vesicles resulted mainly from that of the prosencephalon, and the rate of increase was three times higher on the dorsal side than on the ventral side of the prosencephalon.
authors.affiliation: Human Health Science, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakashima
authors.forename: Ayumi
authors.initials: A
authors.lastname: Hirose
authors.forename: Shigehito
authors.initials: S
authors.lastname: Yamada
authors.forename: Chigako
authors.initials: C
authors.lastname: Uwabe
authors.forename: Katsumi
authors.initials: K
authors.lastname: Kose
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Takakuwa
mesh_terms: D018070:Biological Specimen Banks; D001921:Brain / Q000196:embryology*; D001931:Brain Mapping / Q000379:methods; D015509:Developmental Biology / Q000379:methods; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008636:Mesencephalon / Q000196:embryology; D016548:Prosencephalon / Q000196:embryology; D012249:Rhombencephalon / Q000196:embryology; D013116:Spinal Cord / Q000196:embryology; D013997:Time Factors