title: Premature closure of the foramen ovale secondary to congenital aortic valvular stenosis in a stillborn.
abstract: Premature closure of the foramen ovale is a rare and deleterious condition that can occur as an isolated defect or in association with other congenital and cardiovascular anomalies. We report on the pathologic findings in a 22-week stillborn male fetus with premature closure of the foramen ovale, severe aortic valve stenosis, cardiomegaly, intact atrial and ventricular septa, hypoplasia of the ascending aorta, and hypoplastic aortic arch with a preductal coarctation ridge. To the best of our knowledge, this is only the second report on this rare constellation of complex congenital cardiac defects.
authors.affiliation: University of Utah Health Sciences Center, Department of Pathology, Salt Lake City, Utah 84112, USA. larissa.furtado@hsc.utah.edu
authors.forename: Larissa V
authors.initials: LV
authors.lastname: Furtado
authors.forename: Angelica R
authors.initials: AR
authors.lastname: Putnam
authors.forename: Lance K
authors.initials: LK
authors.lastname: Erickson
authors.forename: John M
authors.initials: JM
authors.lastname: Opitz
mesh_terms: D001024:Aortic Valve Stenosis / Q000150:complications / Q000151:congenital* / Q000473:pathology; D005313:Fetal Death; D005315:Fetal Diseases / Q000473:pathology*; D005333:Fetus; D054085:Foramen Ovale / Q000473:pathology*; D006330:Heart Defects, Congenital / Q000473:pathology*; D006801:Humans; D008297:Male; D050497:Stillbirth