title: Trifluoroacetic anhydride promoted tandem conjugate addition of boronic acids/acetal ring opening.
abstract: A new stereoselective tandem reaction consisting of the metal-free conjugate addition of boronic acids followed by an intramolecular ring opening of a cyclic acetal has been disclosed. Optically pure polysubstituted tetrahydropyrans have been synthesized diastereoselectively by this new reaction. Two new C-C bonds and up to three stereocenters are formed in a single step, allowing the generation of quaternary stereocenters.
authors.affiliation: Laboratorio de Síntesis Orgánica, Unidad de Cartografía Cerebral, Instituto Pluridisciplinar, Universidad Complutense, 28040 Madrid, Spain.
authors.forename: Silvia
authors.initials: S
authors.lastname: Roscales
authors.forename: Aurelio G
authors.initials: AG
authors.lastname: Csáky