title: Association between IRS-2 G1057D polymorphism and risk of gastric cancer.
abstract: OBJECTIVE
  To investigate the relationship between insulin receptor substrate-2 (IRS-2) G1057D polymorphism and the risk of gastric cancer (GC) in a Chinese population.
  
  
  METHODS
  A case-control study with 197 GC patients and 156 age- and sex- matched control subjects was conducted. The genotypes of polymorphism were assessed by polymerase chain reaction-restriction fragment length polymorphism.
  
  
  RESULTS
  The genotype frequencies of IRS-2 G1057D polymorphism in cases were obviously different from those in the control group (P = 0.031). Compared with GG genotype carriers, the risk for GC was significantly higher (adjusted odds ratio = 2.32, 95% CI: 1.03-5.23, P = 0.042) in the individuals with the IRS-2 DD genotype. Furthermore, stratified analysis was performed based on age, sex, smoking status and residence, but no significant difference between the two groups was found. In addition, no significant association between genotypes and clinicopathological features was observed either.
  
  
  CONCLUSIONS
  This study demonstrates that IRS-2 G1057D is involved in susceptibility to GC, although further large-sample studies are still needed.
authors.affiliation: Xiao-Mei Zhao, Xuan Luo, Lin-Lin Xu, Su-Lan Zhai, Ping Li, Xue-Rong Wang, Department of Pharmacology, Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Zhao
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.forename: Li
authors.initials: L
authors.lastname: Yang
authors.forename: Xuan
authors.initials: X
authors.lastname: Luo
authors.forename: Lin-Lin
authors.initials: LL
authors.lastname: Xu
authors.forename: Dong-Xiao
authors.initials: DX
authors.lastname: Liu
authors.forename: Su-Lan
authors.initials: SL
authors.lastname: Zhai
authors.forename: Ping
authors.initials: P
authors.lastname: Li
authors.forename: Xue-Rong
authors.initials: XR
authors.lastname: Wang