title: The spared nerve injury model of neuropathic pain.
abstract: The spared nerve injury (SNI) model mimics human neuropathic pain related to peripheral nerve injury and is based upon an invasive but simple surgical procedure. Since its first description in 2000, it has displayed a remarkable development. It produces a robust, reliable and long-lasting neuropathic pain-like behaviour (allodynia and hyperalgesia) as well as the possibility of studying both injured and non-injured neuronal populations in the same spinal ganglion. Besides, variants of the SNI model have been developed in rats, mice and neonatal/young rodents, resulting in several possible angles of analysis. Therefore, the purpose of this chapter is to provide a detailed guidance regarding the SNI model and its variants, highlighting its surgical and behavioural testing specificities.
authors.affiliation: Pain Research Unit, Department of Anesthesiology, University Hospital Center, University of Lausanne, Lausanne, Switzerland.
authors.forename: Marie
authors.initials: M
authors.lastname: Pertin
authors.forename: Romain-Daniel
authors.initials: RD
authors.lastname: Gosselin
authors.forename: Isabelle
authors.initials: I
authors.lastname: Decosterd
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D051379:Mice; D009437:Neuralgia / Q000209:etiology* / Q000473:pathology; D017288:Pain Threshold; D059348:Peripheral Nerve Injuries / Q000150:complications / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley