title: Role of serotonin 5-HT1B receptors in psychostimulant addiction.
abstract: Psychostimulant (cocaine, amphetamine and its derivatives)  addiction is an important health problem with implications in social and economic life. Although mesocorticolimbic dopamine system plays a crucial role in the mechanism responsible for the rewarding effects of these drugs, recent data also show involvement of the brain serotonin (5-HT) system. In the present review we discuss the role of 5-HT(1B) receptors in the psychostimulant addiction on the base of the effects of 5-HT(1B) receptor ligands on the behavioral effects of the psychostimulants in experimental models (sensitization, intracranial self-stimulation, conditioned place preference, self-administration and extinction/reinstatement model) used to assess their addictive properties. Moreover, the effect of long-term treatment with psychostimulants on 5-HT(1B) receptors is also discussed.
authors.affiliation: Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smętna 12, PL 31-343 Kraków, Poland.
authors.forename: Joanna
authors.initials: J
authors.lastname: Miszkiel
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Filip
authors.forename: Edmund
authors.initials: E
authors.lastname: Przegaliński
mesh_terms: D000818:Animals; D016739:Behavior, Addictive / Q000188:drug therapy / Q000503:physiopathology* / Q000523:psychology; D000697:Central Nervous System Stimulants / Q000008:administration & dosage*; D006801:Humans; D044302:Receptor, Serotonin, 5-HT1B / Q000502:physiology*; D012201:Reward; D012646:Self Administration; D058829:Serotonin 5-HT1 Receptor Antagonists / Q000627:therapeutic use
chemical_list: D000697:Central Nervous System Stimulants; D044302:Receptor, Serotonin, 5-HT1B; D058829:Serotonin 5-HT1 Receptor Antagonists