title: Treatment outcomes of pulpotomy in permanent molars with irreversible pulpitis using biomaterials: a multi-center randomized controlled trial.
abstract: OBJECTIVE
  To conduct a randomized clinical trial to compare the post-operative pain experience as well as clinical and radiographic outcomes of pulpotomy in human permanent molars with irreversible pulpitis using calcium enriched mixture (CEM) cement or mineral trioxide aggregate (MTA).
  
  
  METHODS
  A total of 413 patients met the inclusion criteria and consented to participate. The patients were randomly allocated into two study arms: MTA pulpotomy (PMTA: n = 208) and CEM pulpotomy (PCEM: n = 205). Numerical rating scale questionnaires were utilized by the patients to record pain intensity (PI) over 7 days post-operatively. The patients were followed-up for 12 months to assess the clinical and radiographic outcomes of treatment. The data was analyzed using Chi-square, Cohen's kappa and t-tests.
  
  
  RESULTS
  There was no significant difference in the mean PI recorded during the 7 post-operative days between the two study arms (p = 0.221). The clinical and radiographic success rates for PMTA at 12-month follow-up were 98 and 95%, respectively; and 97 and 92% for PCEM, respectively. There was no significant differences in clinical (p = 0.7) and radiographic (p = 0.4) success rates between the two arms.
  
  
  CONCLUSIONS
  Excellent treatment outcomes occurred in molar teeth with irreversible pulpitis undergoing pulpotomy with MTA and CEM biomaterials.
authors.affiliation: Iranian Center for Endodontic Research, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Saeed
authors.initials: S
authors.lastname: Asgary
authors.forename: Mohammad Jafar
authors.initials: MJ
authors.lastname: Eghbal
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D017607:Aluminum Compounds / Q000627:therapeutic use*; D002118:Calcium; D017610:Calcium Compounds / Q000627:therapeutic use*; D016009:Chi-Square Distribution; D002648:Child; D003738:Dental Cements / Q000737:chemistry / Q000627:therapeutic use*; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008963:Molar / Q000473:pathology*; D015588:Observer Variation; D010087:Oxides / Q000627:therapeutic use*; D010149:Postoperative Pain / Q000628:therapy; D011671:Pulpitis / Q000628:therapy*; D011672:Pulpotomy / Q000379:methods*; D012387:Root Canal Filling Materials / Q000627:therapeutic use*; D017640:Silicates / Q000627:therapeutic use*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D017607:Aluminum Compounds; D017610:Calcium Compounds; D003738:Dental Cements; D004338:Drug Combinations; D010087:Oxides; D012387:Root Canal Filling Materials; D017640:Silicates; C086631:mineral trioxide aggregate; D002118:Calcium