title: [Regeneration of the liver of Chinese hamster Cricetulus griseus].
abstract: Using cytofluorimetry and interferometry, hepatocyte DNA, dry mass and distribution of hepatocyte ploidy classes were measured in hamsters Cricetulus griseus in 1 month after partial hepatoctomy. Ploidy of normal liver hepatocyte was 2.35 +/- 0.03 (mean +/- SD) c. Modal ploidy class was presented by mononuclear hepatocytes with diploid nuclei (82.4 +/- 1.3 %). Hepatocyte dry mass was 605.2 +/- 4.8 pg. One month after partial hepatectomy the distribution of ploidy classes and dry mass of hepatocyte did not change. A similar hepatectomy in mice resulted in significant polyploidization of liver parenchyma: the middle level of hepatocyte ploidy increased by 32% and mononuclear octaploid cells, the number of which increased 5-fold, composed modal ploidy class in place of 4cx2-hepatocytes predominated in control mice. The number of 8cx2-hepatocytes in the liver of mice creased by more than 5-fold. Thus, in contrast with mice, in hamsters Cricetulus griseus an increase in the liver mass followed partial hepatectomy depended completely on hepatocyte proliferation.
authors.forename: G A
authors.initials: GA
authors.lastname: Sakuta
authors.forename: E V
authors.initials: EV
authors.lastname: Baĭdiuk
authors.forename: A A
authors.initials: AA
authors.lastname: Zhumagalieva
authors.forename: B N
authors.initials: BN
authors.lastname: Kudriavtsev
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000648:ultrastructure; D049109:Cell Proliferation; D006224:Cricetinae; D003412:Cricetulus; D005260:Female; D006498:Hepatectomy; D022781:Hepatocytes / Q000166:cytology* / Q000378:metabolism; D007621:Karyotyping; D008099:Liver / Q000166:cytology* / Q000502:physiology / Q000601:surgery; D008115:Liver Regeneration / Q000502:physiology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008853:Microscopy; D011003:Ploidies; D013045:Species Specificity