title: Design, synthesis, and biological evaluations of aplyronine A-mycalolide B hybrid compound.
abstract: A hybrid compound consisting of aplyronine A and mycalolide B was synthesized, and its biological activities were evaluated. The hybrid compound was found to have somewhat more potent actin-depolymerizing activity than aplyronine A. In contrast, the hybrid compound possessed about 1000-fold less cytotoxicity than aplyronine A. These results indicated that there is no direct correlation between actin-depolymerizing activity and cytotoxicity.
authors.affiliation: Department of Chemistry, Graduate School of Pure and Applied Sciences, University of Tsukuba, Tennodai, Tsukuba 305-8571, Japan.
authors.forename: Kenichi
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Fujii
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Hirayama
authors.forename: Shinichi
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Ichiro
authors.initials: I
authors.lastname: Hayakawa
authors.forename: Hideo
authors.initials: H
authors.lastname: Kigoshi
mesh_terms: D002470:Cell Survival / Q000187:drug effects; D015195:Drug Design; D006367:HeLa Cells; D006801:Humans; D018942:Macrolides / Q000138:chemical synthesis* / Q000494:pharmacology; D008387:Marine Toxins; D008958:Models, Molecular; D015394:Molecular Structure; D010080:Oxazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D018942:Macrolides; D008387:Marine Toxins; D010080:Oxazoles; C080978:mycalolide B; C104057:aplyronine A