title: Increased arterial stiffness in subjects with impaired glucose tolerance and newly diagnosed diabetes but not isolated impaired fasting glucose.
abstract: BACKGROUND
  Studies have shown that diabetes mellitus increased brachial-ankle pulse-wave velocity (baPWV), but the impact of impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) remains controversial.
  
  
  OBJECTIVE
  Our objective was to investigate the impact of the different glycemic states on baPWV in a relatively healthy Chinese population.
  
  
  METHODS
  We enrolled 4938 subjects in the health examination center of the National Cheng Kung University Hospital from October 2006 to August 2009 after excluding those who were under medications for diabetes, hypertension, or hyperlipidemia or had a history of cardiovascular disease.
  
  
  METHODS
  The baPWV values to assess arterial stiffness were calculated as the distance traveled by the pulse wave divided by the time taken to travel the distance. The participants were classified into normal glucose tolerance (NGT; n = 3777), isolated IFG (n = 221), IGT (n = 726), and newly diagnosed diabetes (NDD; n = 214) groups.
  
  
  RESULTS
  The mean values of baPWV were 1284.9 ± 205.2, 1379.6 ± 226.8, 1408.1 ± 251.7, and 1500.8 ± 282.5 cm/sec in NGT, isolated IFG, IGT, and NDD groups, respectively. The isolated IFG, IGT, and NDD groups had a higher baPWV value as compared with the NGT group. In a multiple linear regression test, both IGT and NDD groups, but not the isolated IFG group, had significantly higher baPWV values after adjustment for age, sex, body mass index, waist to hip ratio, smoking, alcohol consumption, habitual exercise, systolic blood pressure, and lipid profiles.
  
  
  CONCLUSIONS
  Subjects with IGT and NDD, but not isolated IFG, exhibit a greater arterial stiffness.
authors.affiliation: Department of Family Medicine, National Cheng Kung University Hospital, 138 Sheng Li Road, Tainan, 70441 Taiwan, Republic of China. em75210@email.ncku.edu.tw
authors.forename: Chung-Hao
authors.initials: CH
authors.lastname: Li
authors.forename: Jin-Shang
authors.initials: JS
authors.lastname: Wu
authors.forename: Yi-Ching
authors.initials: YC
authors.lastname: Yang
authors.forename: Chi-Chen
authors.initials: CC
authors.lastname: Shih
authors.forename: Feng-Hwa
authors.initials: FH
authors.lastname: Lu
authors.forename: Chih-Jen
authors.initials: CJ
authors.lastname: Chang
mesh_terms: D000328:Adult; D055109:Ankle Brachial Index; D001786:Blood Glucose / Q000032:analysis; D002318:Cardiovascular Diseases / Q000453:epidemiology; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000208:ethnology / Q000378:metabolism / Q000503:physiopathology*; D018450:Disease Progression; D005260:Female; D018149:Glucose Intolerance / Q000097:blood / Q000208:ethnology / Q000378:metabolism / Q000503:physiopathology*; D005951:Glucose Tolerance Test; D006785:Hospitals, University; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000208:ethnology / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013624:Taiwan; D059289:Vascular Stiffness
chemical_list: D001786:Blood Glucose