title: Long-distance signaling from synapse to nucleus via protein messengers.
abstract: The communication between synapses and the cell nucleus has attracted considerable interest for many years. This interest is largely fueled by the idea that synapse-to-nucleus signaling might specifically induce the expression of genes that make long-term memory "stick." However, despite many years of research, it is still essentially unclear how synaptic signals are conveyed to the nucleus, and it remains to a large degree enigmatic how activity-induced gene expression feeds back to synaptic function. In this chapter, we will focus on the activity-dependent synapto-nuclear trafficking of protein messengers and discuss the underlying mechanisms of their retrograde transport and their supposed functional role in neuronal plasticity.
authors.affiliation: PG Neuroplasticity, Leibniz Institute for Neurobiology, Brenneckestr.6, 39118 Magdeburg, Germany.
authors.forename: Anna
authors.initials: A
authors.lastname: Karpova
authors.forename: Julia
authors.initials: J
authors.lastname: Bär
authors.forename: Michael R
authors.initials: MR
authors.lastname: Kreutz
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism; D002450:Cell Communication / Q000502:physiology; D002467:Cell Nucleus / Q000235:genetics* / Q000378:metabolism; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D028884:Karyopherins / Q000235:genetics / Q000378:metabolism; D057567:Memory, Long-Term / Q000502:physiology; D008870:Microtubules / Q000378:metabolism; D016202:N-Methylaspartate / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism; D009473:Neuronal Plasticity / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000378:metabolism; D021381:Protein Transport / Q000502:physiology; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics*; D013569:Synapses / Q000235:genetics* / Q000378:metabolism
chemical_list: D002352:Carrier Proteins; D028884:Karyopherins; D009419:Nerve Tissue Proteins; D018377:Neurotransmitter Agents; D016194:Receptors, N-Methyl-D-Aspartate; D016202:N-Methylaspartate; D002118:Calcium