title: [Effects of inhaled aerosolized iloprost in adult patients with pulmonary arterial hypertension on right heart functions].
abstract: OBJECTIVE
  To explore the immediate effects of inhaled aerosolized iloprost on right heart function in adult patients with pulmonary arterial hypertension (PAH).
  
  
  METHODS
  A total of 30 PAH patients were recruited. Right heart catheterization and echocardiography were performed before and immediately after the inhalation of iloprost (20 µg).
  
  
  RESULTS
  After inhalation, the values of mean pulmonary artery pressure (PAPm) and pulmonary vascular resistances (PVR) decreased markedly (42.5 ± 9.6 to 34.4 ± 11.9 mm Hg, P < 0.001; 9.6 ± 5.7 Wood unit to 7.1 ± 4.8 Wood unit, P < 0.001). And the value of tricuspid annular systolic motion peak velocity (TASm) increased markedly [(10.7 ± 2.1) cm/s vs (11.9 ± 2.5) cm/s, P < 0.01]. The baseline level of TASm was higher in acute responders than non-responders [(12.0 ± 2.2) cm/s vs (10.1 ± 1.8) cm/s, P = 0.01] and TASm increased markedly after inhalation in non-responders [(10.1 ± 1.8) cm/s vs (11.6 ± 2.3) cm/s, P < 0.01].
  
  
  CONCLUSIONS
  The inhalation of iloprost decreases the levels of PAPm and PVR and improve right heart functions in adult PAH patients. For non-responders, right heart function is worse and more benefits may be achieved after the inhalation of iloprost.
authors.affiliation: Department of Cardiology & Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
authors.forename: Xiao-xiao
authors.initials: XX
authors.lastname: Guo
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Tian
authors.forename: Yong-tai
authors.initials: YT
authors.lastname: Liu
authors.forename: Qian
authors.initials: Q
authors.lastname: Wang
authors.forename: Meng-tao
authors.initials: MT
authors.lastname: Li
authors.forename: Xiao-feng
authors.initials: XF
authors.lastname: Zeng
authors.forename: Wen-ling
authors.initials: WL
authors.lastname: Zhu
authors.forename: Quan
authors.initials: Q
authors.lastname: Fang
mesh_terms: D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy / Q000503:physiopathology*; D016285:Iloprost / Q000008:administration & dosage* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014665:Vasodilator Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D016278:Ventricular Function, Right / Q000187:drug effects*; D055815:Young Adult
chemical_list: D014665:Vasodilator Agents; D016285:Iloprost