title: [Study on mRNA expression of immune-related genes in patients with allergic dermatitis induced by trichloroethylene].
abstract: OBJECTIVE
  To study mRNA expression of immune-related genes (Foxp3, GATA3, CTLA4 and T-bet) in peripheral blood of the patients with allergic dermatitis induced by trichloroethylene (TCE).
  
  
  METHODS
  The peripheral blood samples were collected from 8 healthy workers (control group) and 8 patients with allergic dermatitis induced by TCE (case group). Real-time quantitative PCR was applied to detect mRNA expression of immune-related genes (Foxp3, GATA3, CTLA4, T-bet).
  
  
  RESULTS
  The mRNA expression levels of Foxp3, GATA3 and CTLA4 genes increased by 115%, 97% and 241% in case group, as compared with control group (P < 0.01). The mRNA expression level of T-bet gene decreased by 47% in case group, as compared with control group (P < 0.01).
  
  
  CONCLUSIONS
  The mRNA expression levels of some immune-related genes changed in patients with allergic dermatitis induced by TCE, those genes may play an important role in TCE-induced allergy.
authors.affiliation: Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, Guangdong, China. yxu2008@163.com
authors.forename: Xin-yun
authors.initials: XY
authors.lastname: Xu
authors.forename: Yue-feng
authors.initials: YF
authors.lastname: Liu
authors.forename: Juan
authors.initials: J
authors.lastname: Yi
authors.forename: Yue-bin
authors.initials: YB
authors.lastname: Ke
authors.forename: Jian-hui
authors.initials: JH
authors.lastname: Yuan
authors.forename: Hai-yan
authors.initials: HY
authors.lastname: Huang
authors.forename: Ji-yan
authors.initials: JY
authors.lastname: Mao
authors.forename: Kan-langl
authors.initials: KL
authors.lastname: Mao
mesh_terms: D000328:Adult; D060908:CTLA-4 Antigen / Q000378:metabolism; D016022:Case-Control Studies; D009783:Dermatitis, Occupational / Q000235:genetics* / Q000276:immunology*; D005260:Female; D051858:Forkhead Transcription Factors / Q000378:metabolism; D050990:GATA3 Transcription Factor / Q000378:metabolism; D015870:Gene Expression; D006801:Humans; D008297:Male; D012333:RNA, Messenger / Q000235:genetics; D020825:T-Box Domain Proteins / Q000378:metabolism; D014241:Trichloroethylene; D055815:Young Adult; D000098815:T-bet Transcription Factor
chemical_list: D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human; C418974:FOXP3 protein, human; D051858:Forkhead Transcription Factors; D050990:GATA3 Transcription Factor; C494749:GATA3 protein, human; D012333:RNA, Messenger; D020825:T-Box Domain Proteins; D000098815:T-bet Transcription Factor; D014241:Trichloroethylene