title: Non-woven fibrous materials with antibacterial properties prepared by tailored attachment of quaternized chitosan to electrospun mats from maleic anhydride copolymer.
abstract: In order to impart antibacterial properties to microfibrous electrospun materials from styrene/maleic anhydride copolymers, quaternized chitosan derivatives (QCh) containing alkyl substituents of different chain lengths are covalently attached to the mats. A complete inhibition of the growth of bacteria, S. aureus (Gram-positive) and E. coli (Gram-negative), for a contact time of 30–120 min or a decrease of the bacterial titer by 2–3 log units is observed depending on the quaternization degree, the chain length of the alkyl substituent, and the molar mass of QCh. The modified mats are also effective in suppressing the adhesion of pathogenic S. aureus bacteria.
authors.affiliation: Laboratory of Bioactive Polymers, Institute of Polymers, Bulgarian Academy of Sciences, Acad. G. Bonchev Str. Bl. 103A, Sofia, Bulgaria.
authors.forename: Milena
authors.initials: M
authors.lastname: Ignatova
authors.forename: Zhanina
authors.initials: Z
authors.lastname: Petkova
authors.forename: Nevena
authors.initials: N
authors.lastname: Manolova
authors.forename: Nadya
authors.initials: N
authors.lastname: Markova
authors.forename: Iliya
authors.initials: I
authors.lastname: Rashkov
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001422:Bacterial Adhesion / Q000187:drug effects*; D001672:Biocompatible Materials / Q000494:pharmacology*; D048271:Chitosan / Q000737:chemistry; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism*; D008299:Maleic Anhydrides / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D049329:Nanostructures / Q000737:chemistry / Q000648:ultrastructure*; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects / Q000378:metabolism*; D013499:Surface Properties
chemical_list: D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D008299:Maleic Anhydrides; D011108:Polymers; D048271:Chitosan