title: Cold-induced urticaria with a familial transmission: a case report and review of the literature.
abstract: BACKGROUND
  Cryopyrin-associated periodic syndrome is a rare genetic disorder causing cold-induced urticaria, severe arthralgias, and (potentially) renal failure and hearing loss. Therapies that effectively control the symptoms and prevent the complications of this debilitating disorder are now available, making recognition of this disease important.
  
  
  METHODS
  A 60-year-old Caucasian woman presented with complaints of rash and joint pains to a general medicine clinic. Her history showed that her symptoms were linked to cold exposure, but the results of a cold stimulation time test were negative. Several generations of her family had similar symptoms.
  
  
  CONCLUSIONS
  This case highlights the importance of considering cryopyrin-associated periodic syndrome in the differential diagnosis of cold-induced urticaria. Several medications targeting interleukin-1-beta are available, providing significant relief from symptoms and improvement in quality of life in affected patients.
authors.affiliation: Department of Internal Medicine, University of Tennessee at Chattanooga, Chattanooga, TN, USA. joefurr@gmail.com.
authors.forename: Joe C
authors.initials: JC
authors.lastname: Furr
authors.forename: Mukta
authors.initials: M
authors.lastname: Panda