title: Fast and accurate X-ray fluorescence computed tomography imaging with the ordered-subsets expectation maximization algorithm.
abstract: The ordered-subsets expectation maximization algorithm (OSEM) is introduced to X-ray fluorescence computed tomography (XFCT) and studied; here, simulations and experimental results are presented. The simulation results indicate that OSEM is more accurate than the filtered back-projection algorithm, and it can efficiently suppress the deterioration of image quality within a large range of angular sampling intervals. Experimental results of both an artificial phantom and cirrhotic liver show that with a satisfying image quality the angular sampling interval could be improved to save on the data-acquisition time when OSEM is employed. In addition, with an optimum number of subsets, the image reconstruction time of OSEM could be reduced to about half of the time required for one subset. Accordingly, it can be concluded that OSEM is a potential method for fast and accurate XFCT imaging.
authors.affiliation: Shanghai Synchrotron Radiation Facility, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201204, People's Republic of China.
authors.forename: Qun
authors.initials: Q
authors.lastname: Yang
authors.forename: Biao
authors.initials: B
authors.lastname: Deng
authors.forename: Weiwei
authors.initials: W
authors.lastname: Lv
authors.forename: Fei
authors.initials: F
authors.lastname: Shen
authors.forename: Rongchang
authors.initials: R
authors.lastname: Chen
authors.forename: Yudan
authors.initials: Y
authors.lastname: Wang
authors.forename: Guohao
authors.initials: G
authors.lastname: Du
authors.forename: Fuhua
authors.initials: F
authors.lastname: Yan
authors.forename: Tiqiao
authors.initials: T
authors.lastname: Xiao
authors.forename: Hongjie
authors.initials: H
authors.lastname: Xu
mesh_terms: D000465:Algorithms; D000818:Animals; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008106:Liver Cirrhosis, Experimental / Q000000981:diagnostic imaging*; D019047:Phantoms, Imaging; D051381:Rats; D013052:Spectrometry, X-Ray Emission / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000379:methods*; D015032:Zinc / Q000032:analysis
chemical_list: D015032:Zinc