title: Halothane changes the domain structure of a binary lipid membrane.
abstract: X-ray and neutron diffraction studies of a binary lipid membrane demonstrate that halothane at physiological concentrations produces a pronounced redistribution of lipids between domains of different lipid types identified by different lamellar d-spacings and isotope composition. In contrast, dichlorohexafluorocyclobutane (F6), a halogenated nonanesthetic, does not produce such significant effects. These findings demonstrate a specific effect of inhalational anesthetics on mixing phase equilibria of a lipid mixture.
authors.affiliation: National Center for Medical Rehabilitation Research, Eunice Kennedy Shriver Institute of Child Health and Human Development, Bethesda, Maryland, United States. Mw287k@nih.gov
authors.forename: Michael
authors.initials: M
authors.lastname: Weinrich
authors.forename: Hirsh
authors.initials: H
authors.lastname: Nanda
authors.forename: David L
authors.initials: DL
authors.lastname: Worcester
authors.forename: Charles F
authors.initials: CF
authors.lastname: Majkrzak
authors.forename: Brian B
authors.initials: BB
authors.lastname: Maranville
authors.forename: Sergey M
authors.initials: SM
authors.lastname: Bezrukov
mesh_terms: D015060:1,2-Dipalmitoylphosphatidylcholine / Q000737:chemistry; D018685:Anesthetics, Inhalation / Q000494:pharmacology; D006221:Halothane / Q000494:pharmacology*; D008563:Membrane Lipids / Q000737:chemistry*; D008958:Models, Molecular; D033363:Neutron Diffraction; D044367:Phase Transition / Q000187:drug effects; D010713:Phosphatidylcholines / Q000737:chemistry; D014961:X-Ray Diffraction
chemical_list: D018685:Anesthetics, Inhalation; D008563:Membrane Lipids; D010713:Phosphatidylcholines; C015153:1,2-dilauroylphosphatidylcholine; D015060:1,2-Dipalmitoylphosphatidylcholine; D006221:Halothane