title: Familial mesothelioma in first degree relatives.
abstract: Occupational asbestos exposure is believed to be the primary etiologic link to mesothelioma. However, in the evaluation of familial mesothelioma, it is important to consider the possibility of household exposure to asbestos. In this study, we report a family in which the father with prolonged occupational asbestos exposure developed malignant pleural mesothelioma and his daughter 14 years later mesothelioma in situ with focally early invasion. Several reports of familial aggregations of mesothelioma strongly support that genetic factors in collaboration with environmental exposure may contribute etiologically to an as yet unknown fraction of occurrence of this disease.
authors.affiliation: Department of Pathology-Cytopathology, Medical School, University of Crete, Heraklion, Crete, Greece. kalogerakimed@yahoo.gr
authors.forename: Alexandra M
authors.initials: AM
authors.lastname: Kalogeraki
authors.forename: Dimitrios J
authors.initials: DJ
authors.lastname: Tamiolakis
authors.forename: Eleni D
authors.initials: ED
authors.lastname: Lagoudaki
authors.forename: Michael N
authors.initials: MN
authors.lastname: Papadakis
authors.forename: George Z
authors.initials: GZ
authors.lastname: Papadakis
authors.forename: Sofia I
authors.initials: SI
authors.lastname: Agelaki
authors.forename: Efstathios N
authors.initials: EN
authors.lastname: Stathopoulos
authors.forename: Maria N
authors.initials: MN
authors.lastname: Tzardi
mesh_terms: D000328:Adult; D001194:Asbestos / Q000009:adverse effects*; D014408:Biomarkers, Tumor / Q000378:metabolism; D005190:Family; D005192:Family Health; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008654:Mesothelioma / Q000139:chemically induced / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D016273:Occupational Exposure / Q000009:adverse effects*; D010997:Pleural Neoplasms / Q000139:chemically induced / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D012907:Smoking
chemical_list: D014408:Biomarkers, Tumor; D001194:Asbestos