title: Recent achievements on siderophore production and application.
abstract: Iron is the most abundant chemical element on Earth but its most common oxidation state is Fe(III) which presents a very low solubility under physiological conditions. During evolution, micro-organisms have developed sound strategies to acquire iron from both the environment and superior organisms, including direct uptake of iron ions from exogenous iron/heme sources and the synthesis of specialized Fe(III) chelators called siderophores. The present review paper aims at presenting and discussing the latest achievements in siderophore isolation and production, as well as novel applications of these molecules in therapies against iron-related diseases and in vaccines, and their application as antimicrobial agents and biosensors.
authors.affiliation: Department of Bioengineering, Instituto Superior Tecnico, Universidade Tecnica de Lisboa, Portugal. ccarvalho@ist.utl.pt
authors.forename: Carla C C R
authors.initials: CC
authors.lastname: de Carvalho
authors.forename: Marco P C
authors.initials: MP
authors.lastname: Marques
authors.forename: Pedro
authors.initials: P
authors.lastname: Fernandes
mesh_terms: D001419:Bacteria / Q000378:metabolism; D015374:Biosensing Techniques; D005285:Fermentation; D005658:Fungi / Q000378:metabolism; D006801:Humans; D007501:Iron / Q000737:chemistry / Q000378:metabolism; D010330:Patents as Topic; D017262:Siderophores / Q000096:biosynthesis* / Q000302:isolation & purification / Q000627:therapeutic use; D013789:Thalassemia / Q000188:drug therapy
chemical_list: D017262:Siderophores; D007501:Iron