title: DNA interstrand cross-linking agents and their chemotherapeutic potential.
abstract: DNA interstrand cross-linking (ICL) agents are an important group of cytotoxic drugs with the capability of binding covalently between two strands of DNA, thereby preventing vital processes such as replication or transcription in dividing cells. In anticancer therapy however, their potential is limited due to the resistance by various mechanisms. In order to develop highly effective antitumor drugs it is necessary to study both effective ICL formations and their subsequent repair mechanisms. This review presents an overview of development over the past decade and the use of both well-known and new DNA interstrand cross-linking agents. Their potential in applications especially as anticancer chemotherapeutics in the framework of current knowledge of repair mechanisms and development of combined chemotherapy is discussed.
authors.affiliation: Institute of Molecular and Translational Medicine, Department of Organic Chemistry, Faculty of Science, Palacky University, 17. listopadu 12, 771 46 Olomouc, Czech Republic.
authors.forename: L
authors.initials: L
authors.lastname: Brulikova
authors.forename: J
authors.initials: J
authors.lastname: Hlavac
authors.forename: P
authors.initials: P
authors.lastname: Hradil
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000627:therapeutic use; D000880:Anthraquinones / Q000737:chemistry / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000627:therapeutic use; D001381:Azepines / Q000737:chemistry / Q000627:therapeutic use; D001388:Aziridines / Q000737:chemistry / Q000627:therapeutic use; D056831:Coordination Complexes / Q000737:chemistry / Q000627:therapeutic use; D003432:Cross-Linking Reagents / Q000737:chemistry* / Q000627:therapeutic use; D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D004260:DNA Repair; D006801:Humans; D008466:Mechlorethamine / Q000737:chemistry / Q000627:therapeutic use; D009369:Neoplasms / Q000188:drug therapy
chemical_list: D000470:Alkaloids; D000880:Anthraquinones; D000970:Antineoplastic Agents; D001381:Azepines; D001388:Aziridines; D056831:Coordination Complexes; D003432:Cross-Linking Reagents; D008466:Mechlorethamine; C033132:aziridine; D004247:DNA