title: Coenzyme Q10 in salivary cells correlate with blood cells in Fibromyalgia: improvement in clinical and biochemical parameter after oral treatment.
abstract: OBJECTIVE
  We have determined Coenzyme Q(10) (CoQ(10)) levels in salivary cells (SCs) and mononuclear blood cells (BMCs) from Fibromyalgia (FM), and we study the influence of oral CoQ(10) supplementation on cells levels and clinical symptoms.
  
  
  METHODS
  CoQ(10) was determined by high-performance liquid chromatography (HPLC). Ten patients were supplemented daily with 300 mg of CoQ(10) during 3 months.
  
  
  RESULTS
  CoQ(10) were reduced in both cell models. Oral supplementation showed an improvement in clinical symptoms and restored levels.
  
  
  CONCLUSIONS
  Patients with FM showed an important dysfunction in CoQ(10) levels and might benefit from oral supplementation.
authors.affiliation: Centro Andaluz de Biología del Desarrollo, Universidad Pablo de Olavide-CSIC-Junta de Andalucía, ISCIII, Sevilla, Spain. mdcormor@upo.es
authors.forename: Mario D
authors.initials: MD
authors.lastname: Cordero
authors.forename: Rocio
authors.initials: R
authors.lastname: Santos-García
authors.forename: David
authors.initials: D
authors.lastname: Bermejo-Jover
authors.forename: Benito
authors.initials: B
authors.lastname: Sánchez-Domínguez
authors.forename: María Reyes
authors.initials: MR
authors.lastname: Jaramillo-Santos
authors.forename: Pedro
authors.initials: P
authors.lastname: Bullón
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D019587:Dietary Supplements; D005356:Fibromyalgia / Q000097:blood* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D008875:Middle Aged; D018987:Salivary Ducts / Q000378:metabolism / Q000473:pathology*; D016896:Treatment Outcome; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000172:deficiency / Q000493:pharmacokinetics / Q000627:therapeutic use; D014815:Vitamins / Q000493:pharmacokinetics / Q000627:therapeutic use*
chemical_list: D014815:Vitamins; D014451:Ubiquinone; C024989:coenzyme Q10