title: Multifunctional nanoprobe to enhance the utility of optical based imaging techniques.
abstract: Several imaging modalities such as optical coherence tomography, photothermal, photoacoustic and magnetic resonance imaging, are sensitive to different physical properties (i.e. scattering, absorption and magnetic) that can provide contrast within biological tissues. Usually exogenous agents are designed with specific properties to provide contrast for these imaging methods. In nano-biotechnology there is a need to combine several of these properties into a single contrast agent. This multifunctional contrast agent can then be used by various imaging techniques simultaneously or can be used to develop new imaging modalities. We reported and characterized a multifunctional nanoparticle, made from gold nanoshells, which exhibits scattering, photothermal, photoacoustic, and magnetic properties.
authors.affiliation: University of Washington, Department of Bioengineering, 3720 15th Avenue NE, Seattle, Washington 98195, USA.
authors.forename: Yeongri
authors.initials: Y
authors.lastname: Jung
authors.forename: Guangying
authors.initials: G
authors.lastname: Guan
authors.forename: Chen-Wei
authors.initials: CW
authors.lastname: Wei
authors.forename: Roberto
authors.initials: R
authors.lastname: Reif
authors.forename: Xiaohu
authors.initials: X
authors.lastname: Gao
authors.forename: Matthew
authors.initials: M
authors.lastname: O'Donnell
authors.forename: Ruikang K
authors.initials: RK
authors.lastname: Wang
mesh_terms: D000042:Absorption; D003287:Contrast Media / Q000737:chemistry*; D006046:Gold / Q000737:chemistry; D008279:Magnetic Resonance Imaging; D059346:Magnets; D053768:Metal Nanoparticles / Q000737:chemistry*; D008954:Models, Biological; D015335:Molecular Probes / Q000737:chemistry*; D019047:Phantoms, Imaging; D055668:Photochemical Processes; D012542:Scattering, Radiation; D012822:Silicon Dioxide / Q000737:chemistry; D041623:Tomography, Optical Coherence / Q000379:methods*
chemical_list: D003287:Contrast Media; D015335:Molecular Probes; D006046:Gold; D012822:Silicon Dioxide