title: The Csr/Rsm system of Yersinia and related pathogens: a post-transcriptional strategy for managing virulence.
abstract: This review emphasizes the function and regulation of the Csr regulatory system in the human enteropathogen Yersinia pseudotuberculosis and compares its features with the homologous Csr/Rsm systems of related pathogens. The Csr/Rsm systems of eubacteria form a complex regulatory network in which redundant non-translated Csr/Rsm-RNAs bind the RNA-binding protein CsrA/RsmA, thereby preventing its interaction with mRNA targets. The Csr system is controlled by the BarA/UvrY-type of two-component sensor-regulator systems. Apart from that, common or pathogen-specific regulators control the abundance of the Csr components. The coordinate control of virulence factors and infection-linked physiological traits by the Csr/Rsm systems helps the pathogens to adapt individually to rapidly changing conditions to which they are exposed during the different stages of an infection. As Csr/Rsm function is relevant for full virulence, it represents a target suitable for antimicrobial drug development.
authors.affiliation: Department of Molecular Infection Biology, Helmholtz Centre for Infection Research, Braunschweig, Germany.
authors.forename: Ann Kathrin
authors.initials: AK
authors.lastname: Heroven
authors.forename: Katja
authors.initials: K
authors.lastname: Böhme
authors.forename: Petra
authors.initials: P
authors.lastname: Dersch
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000502:physiology*; D015964:Gene Expression Regulation, Bacterial; D054884:Host-Pathogen Interactions; D006801:Humans; D010802:Phylogeny; D012323:RNA Processing, Post-Transcriptional; D058727:RNA, Small Untranslated / Q000235:genetics / Q000502:physiology; D016601:RNA-Binding Proteins / Q000235:genetics / Q000502:physiology*; D014774:Virulence / Q000235:genetics; D015011:Yersinia pseudotuberculosis / Q000235:genetics* / Q000472:pathogenicity / Q000502:physiology; D015012:Yersinia pseudotuberculosis Infections / Q000382:microbiology
chemical_list: D001426:Bacterial Proteins; D058727:RNA, Small Untranslated; D016601:RNA-Binding Proteins