title: Glutamatergic neurotransmission as molecular target of new anticonvulsants.
abstract: Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS) controlling physiological processes as learning and memory. However, the overactivation of glutamatergic neurotransmission is often related to various CNS chronic and acute diseases (epilepsy, ischaemia, Parkinson, etc.). This review will focus on the chemical structures, mechanism of action and main structure-activity relationships of anticonvulsant agents acting through glutamate neurotransmission.
authors.affiliation: Dipartimento Farmaco-Chimico, Università di Messina, Viale Annunziata, 98168 Messina, Italy. rgitto@unime.it
authors.forename: Rosaria
authors.initials: R
authors.lastname: Gitto
authors.forename: Laura
authors.initials: L
authors.lastname: De Luca
authors.forename: Sara
authors.initials: S
authors.lastname: De Grazia
authors.forename: Alba
authors.initials: A
authors.lastname: Chimirri
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000737:chemistry / Q000494:pharmacology*; D002493:Central Nervous System Diseases / Q000188:drug therapy* / Q000378:metabolism; D018691:Excitatory Amino Acid Antagonists; D005971:Glutamates / Q000378:metabolism*; D006801:Humans; D013329:Structure-Activity Relationship; D009435:Synaptic Transmission / Q000187:drug effects*
chemical_list: D000927:Anticonvulsants; D018691:Excitatory Amino Acid Antagonists; D005971:Glutamates