title: Synthesis of pyrido[1,2-a]indole malonates and amines through aryne annulation.
abstract: Pyrido[1,2-a]indoles are known as medicinally and pharmaceutically important compounds, but there is a lack of efficient methods for their synthesis. We report a convenient and efficient route to these privileged structures starting from easily accessible 2-substituted pyridines and aryne precursors. A small library of compounds has been synthesized utilizing the developed method, affording variously substituted pyrido[1,2-a]indoles in moderate to good yields.
authors.affiliation: Department of Chemistry, Iowa State University, Ames, Iowa 50011, USA.
authors.forename: Donald C
authors.initials: DC
authors.lastname: Rogness
authors.forename: Nataliya A
authors.initials: NA
authors.lastname: Markina
authors.forename: Jesse P
authors.initials: JP
authors.lastname: Waldo
authors.forename: Richard C
authors.initials: RC
authors.lastname: Larock
mesh_terms: D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D008314:Malonates / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D000588:Amines; D007211:Indoles; D008314:Malonates