title: Solvent-free Michael addition to non-protected 3-(2-nitrovinyl)indole by ultrasound activation.
abstract: A variety of nucleophiles provided by activated methylenes have been added on 3-(2-nitrovinyl)-1H-indole in very good to excellent yields, under sonication and solvent-free conditions, using solid potassium carbonate or sodium acetate as a base. Direct synthesis avoiding preliminary NH protection is reported and exemplified to 15 molecules.
authors.affiliation: Equipe Catalyse Synthèse Environnement, Institut de Chimie et Biochimie Moléculaires et Supramoléculaires, UMR-CNRS 5246, Université de Lyon, Bâtiment Curien, 43 boulevard du 11 Novembre 1918, F-69622 Villeurbanne Cedex, France.
authors.forename: Marc
authors.initials: M
authors.lastname: Baron
authors.forename: Estelle
authors.initials: E
authors.lastname: Métay
authors.forename: Marc
authors.initials: M
authors.lastname: Lemaire
authors.forename: Florence
authors.initials: F
authors.lastname: Popowycz