title: A new class of heterocycles: 1,4,3,5-oxathiadiazepane 4,4-dioxides.
abstract: This work reports the synthesis of novel 1,4,3,5-oxathiadiazepanes 4,4-dioxides from the reaction of N'-benzyl-N-(2-hydroxyethyl)-sarcosine or proline sulfamide with aromatic aldehydes under acid catalysis. To prepare the starting materials N-Boc-sulfamide derivatives of sarcosine or proline were alkylated with benzyl alcohol under Mitsunobu reaction conditions, the Boc group was removed chemoselectively by acidolysis, and the resulting product reduced to the corresponding alcohol in good yields.
authors.affiliation: Laboratoire de Chimie Organique Appliquée, Groupe de chimie Hétérocyclique, Département de Chimie, Université d'Annaba, BP 12, 23000, Algérie. bendjeddouamel@gmail.com
authors.forename: Amel
authors.initials: A
authors.lastname: Bendjeddou
authors.forename: Tahar
authors.initials: T
authors.lastname: Abbaz
authors.forename: Zine
authors.initials: Z
authors.lastname: Regainia
authors.forename: Nour-Eddine
authors.initials: NE
authors.lastname: Aouf
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000478:Alkylation; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D010087:Oxides / Q000138:chemical synthesis* / Q000737:chemistry; D012521:Sarcosine / Q000737:chemistry; D016339:Spectrometry, Mass, Fast Atom Bombardment
chemical_list: D000447:Aldehydes; D006571:Heterocyclic Compounds; D010087:Oxides; D012521:Sarcosine