title: Serum amyloid P component accelerates the formation and enhances the stability of amyloid fibrils in a physiologically significant under-saturated solution of amyloid-β42.
abstract: The mechanism whereby an under-saturated solution of amyloid-β (Aβ)42 precipitates as β sheets in vivo in Alzheimer's disease remains to be elucidated. Herein we present in vitro evidence that serum amyloid P component may mediate this process through its acceleration of amyloid formation from an under-saturated solution of Aβ42 and subsequently its stabilization of the amyloid fibrils formed over physiologically significant timeframes. Our observations support serum amyloid P component as a therapeutic target in Alzheimer's disease.
authors.affiliation: The Birchall Centre, Lennard-Jones Laboratories, Keele University, Staffordshire, UK.
authors.forename: Matthew
authors.initials: M
authors.lastname: Mold
authors.forename: Annette K
authors.initials: AK
authors.lastname: Shrive
authors.forename: Christopher
authors.initials: C
authors.lastname: Exley
mesh_terms: D000535:Aluminum / Q000494:pharmacology; D000682:Amyloid / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D016229:Amyloid beta-Peptides / Q000494:pharmacology*; D000818:Animals; D002118:Calcium / Q000378:metabolism; D003300:Copper / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005947:Glucose / Q000494:pharmacology; D006801:Humans; D008274:Magnesium / Q000494:pharmacology; D010446:Peptide Fragments / Q000494:pharmacology*; D017433:Protein Structure, Secondary; D000683:Serum Amyloid P-Component / Q000187:drug effects* / Q000378:metabolism* / Q000494:pharmacology / Q000648:ultrastructure; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D014325:Tromethamine / Q000494:pharmacology
chemical_list: D000682:Amyloid; D016229:Amyloid beta-Peptides; C074097:Krebs-Henseleit solution; D010446:Peptide Fragments; D000683:Serum Amyloid P-Component; C075222:amyloid beta-protein (1-42); D014325:Tromethamine; D003300:Copper; D000535:Aluminum; D008274:Magnesium; D005947:Glucose; D002118:Calcium