title: Criteria and outcome of limb salvage surgery.
abstract: When sufficient margins of resection surrounding the tumor can be achieved, limb salvage surgery, as opposed to amputation, has become the standard of care in treating patients with bone and soft tissue sarcoma of the extremities. Currently, 90-95% of patients with primary malignant bone and soft-tissue tumors involving the extremities can be treated safely with wide resection and limb salvage surgery with a low risk of recurrence and the same disease-free survival rate as amputative surgery. However, discussions persist regarding the indications and criteria, and whether limb salvage provides superior functional results and quality of life for cancer patients. In this study we aimed to review and update the current criteria, indications and contraindications of limb salvage surgery and discuss its role in the quality of life of cancer patients.
authors.affiliation: Department of Orthopedics, University of Bologna, Istituto Ortopedico Rizzoli, Bologna, Italy. andreasfmavrogenis@yahoo.gr
authors.forename: A F
authors.initials: AF
authors.lastname: Mavrogenis
authors.forename: L
authors.initials: L
authors.lastname: Coll-Mesa
authors.forename: M
authors.initials: M
authors.lastname: Gonzalez-Gaitan
authors.forename: R
authors.initials: R
authors.lastname: Ucelay-Gomez
authors.forename: N
authors.initials: N
authors.lastname: Fabri
authors.forename: P
authors.initials: P
authors.lastname: Ruggieri
authors.forename: P J
authors.initials: PJ
authors.lastname: Papagelopoulos
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000473:pathology / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D023821:Limb Salvage / Q000379:methods*; D012509:Sarcoma / Q000473:pathology / Q000601:surgery*; D016896:Treatment Outcome