title: [Expression pattern and clinical significance of hairy enhancer of split 1 in colorectal cancer].
abstract: OBJECTIVE
  To explore the roles of hairy enhancer of split 1 (Hes1) gene in colorectal cancer and analyze its clinical significance.
  
  
  METHODS
  A total of 146 cases with colorectal cancer at our hospital were collected prospectively and followed up. There were 84 males and 62 females with an average age of (61 ± 11) years old. Tissue microarray was prepared and the expression of Notch signal genes were detected by immunohistochemical staining.
  
  
  RESULTS
  The differential expressions of Hes1 were significant among various types [negative or weakly positive: 8% (12/146), positive(+): 77% (112/146), positive(++): 15% (22/146)]. Among all, 134 were followed up successfully for an average duration of (42 ± 13) months. According to the Kaplan-Meier life curve, the overall 1, 3 and 5-year survival rates were 93% (136/146), 74% (108/146) and 67% (98/146) respectively. The long-term survival rate was correlated with TNM stage and pathological types (all P = 0.000), but not with Hes1 (P = 0.267).
  
  
  CONCLUSIONS
  The expression of Hes1 is correlated with pathological types and differentiation types. However the long-term survival rate is not correlated with its expression.
authors.affiliation: Nanjing University of Traditional Chinese Medicine, Jiangsu Integrated Colorectal Oncology Center, Nanjing, China. jinheiying@yahoo.com.cn
authors.forename: Hei-ying
authors.initials: HY
authors.lastname: Jin
authors.forename: Jun-hua
authors.initials: JH
authors.lastname: Xu
authors.forename: Xiao-feng
authors.initials: XF
authors.lastname: Wang
authors.forename: Yi-jiang
authors.initials: YJ
authors.lastname: Ding
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics / Q000378:metabolism*; D015179:Colorectal Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D011446:Prospective Studies; D015996:Survival Rate; D000072056:Transcription Factor HES-1; D055815:Young Adult
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D018398:Homeodomain Proteins; D000072056:Transcription Factor HES-1; C078493:HES1 protein, human