title: Navigation-guided endoscopic biopsy for pathological diagnosis for intraparenchymal pure germinoma near the ventricular trigone.
abstract: BACKGROUND
  The authors report a case of intraparenchymal germinoma pathologically diagnosed using navigation-guided endoscopic biopsy.
  
  
  METHODS
  A 27-year-old man had mild left hemiparesis, transcortical motor aphasia, and amnesia. Magnetic resonance (MR) imaging revealed an intraparenchymal mass lesion near the left ventricular trigone. Navigation-guided endoscopic biopsy was performed, and histopathology revealed large neoplastic cells immunohistochemically positive for germinoma-specific antigens, which were diagnosed as pure germinoma. Chemotherapy with whole-brain radiotherapy was performed, and the neurological symptoms did not change during the treatment. Follow-up MR imaging 1 year after the surgery showed no evidence of recurrence or dissemination.
  
  
  CONCLUSIONS
  Navigation-guided endoscopic biopsy can be a useful technique in such intraparenchymal germinoma cases.
authors.affiliation: Department of Neurosurgery, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.
authors.forename: Kuniyuki
authors.initials: K
authors.lastname: Onuma
authors.forename: Eiichi
authors.initials: E
authors.lastname: Ishikawa
authors.forename: Masahide
authors.initials: M
authors.lastname: Matsuda
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Shibata
authors.forename: Kaishi
authors.initials: K
authors.lastname: Satomi
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Alexander
authors.initials: A
authors.lastname: Zaboronok
authors.forename: Shingo
authors.initials: S
authors.lastname: Takano
authors.forename: Akira
authors.initials: A
authors.lastname: Matsumura