title: Prevention of relapses of nasal polyposis with intranasal triamcinolone acetonide after polyp surgery: a prospective double-blind, placebo-controlled, randomised study with a 9-month follow-up.
abstract: OBJECTIVE
  To determine whether intranasal triamcinolone acetonide prevents the regrowth of nasal polyps after polyp surgery.
  
  
  METHODS
  Randomised, double-blind, placebo-controlled, prospective study.
  
  
  METHODS
  Helsinki University Central Hospital.
  
  
  METHODS
  Sixty patients with nasal polyps entered the study. Patients were included upon arrival for elective polyp operations determined according to our standard clinical criteria. The recurrence of nasal polyposis was followed up for 9 months after surgical treatment at 3-month intervals.
  
  
  METHODS
  Anterior rhinoscopy, nasal endoscopy, olfactory threshold measurement, active anterior rhinomanometry and acoustic rhinometry were performed at every follow-up visit.
  
  
  RESULTS
  On the whole, there was a significant inter-group difference in the change in polyp size of acetylsalicylic acid (ASA)-tolerant patients during the follow-up. In patients with acetylsalicylic acid intolerance, there was no inter-group difference (P = 0.28). No significant differences were noted for nasal resistance, nasal cavity volume, sense of smell and nasal symptoms.
  
  
  CONCLUSIONS
  Triamcinolone acetonide prevents regrowth of nasal polyps after polyp surgery in acetylsalicylic acid-tolerant patients, but not in acetylsalicylic acid-intolerant patients.
authors.affiliation: Department of Otorhinolaryngology--Head and Neck Surgery, Helsinki University, Central Hospital, Helsinki, Finland. seija.vento@hus.fi
authors.forename: S I
authors.initials: SI
authors.lastname: Vento
authors.forename: K
authors.initials: K
authors.lastname: Vento
authors.forename: K
authors.initials: K
authors.lastname: Blomgren
authors.forename: M
authors.initials: M
authors.lastname: Hytönen
authors.forename: M
authors.initials: M
authors.lastname: Simola
authors.forename: H
authors.initials: H
authors.lastname: Malmberg
mesh_terms: D000281:Administration, Intranasal; D000328:Adult; D000368:Aged; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004724:Endoscopy; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000175:diagnosis / Q000517:prevention & control* / Q000601:surgery; D059747:Nasal Surgical Procedures; D011182:Postoperative Care / Q000379:methods*; D011446:Prospective Studies; D025363:Rhinomanometry; D055502:Secondary Prevention; D013997:Time Factors; D016896:Treatment Outcome; D014222:Triamcinolone Acetonide / Q000008:administration & dosage*; D055815:Young Adult
chemical_list: D005938:Glucocorticoids; D014222:Triamcinolone Acetonide