title: Hemorrhagic onset of rhabdoid meningioma after initiating treatment for infertility.
abstract: Rhabdoid meningioma (RM) is a rare aggressive phenotype and is classified as a grade III neoplasm by the World Health Organization. A 29-year-old woman initiated treatment with clomiphene citrate for infertility. Two weeks later, she presented with acute headache and nausea. Brain computed tomography and magnetic resonance imaging demonstrated a tumor with hematoma in the left frontoparietal region. Surgical resection was performed, and the tumor was subtotally removed. The tumor was diagnosed as a rhabdoid meningioma (RM). Despite radiation and chemotherapy, she experienced regrowth and dissemination to the spinal cord. She died 11 months after onset of symptoms. Spontaneous hemorrhage is an unusual presentation of RM. In our case, infertility treatment may have triggered progression and bleeding because of an imbalance of sex hormones.
authors.affiliation: Department of Neurosurgery, Hokkaido University Graduate School of Medicine, North 15 West 7, Kita-ku, Sapporo 060-8638, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Motegi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Terasaka
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Ishii
authors.forename: Masaki
authors.initials: M
authors.lastname: Ito
authors.forename: Daisuke
authors.initials: D
authors.lastname: Shimbo
authors.forename: Kanako
authors.initials: K
authors.lastname: Kubota
authors.forename: Kiyohiro
authors.initials: K
authors.lastname: Houkin
mesh_terms: D000328:Adult; D002996:Clomiphene / Q000009:adverse effects / Q000627:therapeutic use; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D005260:Female; D005300:Fertility Agents, Female / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy / Q000209:etiology*; D020300:Intracranial Hemorrhages / Q000209:etiology*; D008279:Magnetic Resonance Imaging; D008579:Meningioma / Q000150:complications* / Q000473:pathology / Q000601:surgery; D009044:Motor Cortex / Q000473:pathology; D019635:Neurosurgical Procedures; D018335:Rhabdoid Tumor / Q000150:complications* / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed
chemical_list: D005300:Fertility Agents, Female; D002996:Clomiphene