title: [Effects of parenteral lipid emulsions on immune system response].
abstract: Lipid solutions used in parenteral nutrition (PN) are generally well tolerated. Recent studies reporting their effects on the immune system indicate that various compositions can modulate the immune response, thus affecting the response to pathogens and autoaggressive diseases. In this review, we discuss the compositions of various commercially available lipid solutions and their effects on the immune response to various pathologies.    We conclude that: 1. Soybean oil-based emulsions are immunosuppressive and should be used with caution in inflammatory conditions, and are contraindicated in sepsis. 2. Mixtures of medium chain triglycerides and soybean oil are better tolerated. 3. Olive oil-based mixtures are neutral and are especially recommended for burned patients, premature infants and for long term PN. 4. Fish oil-based emulsions are beneficial in inflammatory conditions and in patients after major abdominal surgery.
authors.affiliation: Klinika Immunologii Klinicznej, Reumatologii i Alergii, Uniwersytet Medyczny w Łodzi.
authors.forename: Monika
authors.initials: M
authors.lastname: Jędrzejczak-Czechowicz
authors.forename: Marek L
authors.initials: ML
authors.lastname: Kowalski
mesh_terms: D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage* / Q000009:adverse effects; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage* / Q000009:adverse effects; D005395:Fish Oils / Q000008:administration & dosage* / Q000009:adverse effects; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007109:Immunity / Q000187:drug effects*; D000069463:Olive Oil; D010289:Parenteral Nutrition, Total / Q000379:methods; D010938:Plant Oils / Q000008:administration & dosage* / Q000009:adverse effects; D013024:Soybean Oil / Q000008:administration & dosage; D014280:Triglycerides / Q000008:administration & dosage*
chemical_list: D004042:Dietary Fats, Unsaturated; D005217:Fat Emulsions, Intravenous; D005395:Fish Oils; D000069463:Olive Oil; D010938:Plant Oils; D014280:Triglycerides; D013024:Soybean Oil