title: Metabolic manifestations of polycystic ovary syndrome in nonobese adolescents: retinol-binding protein 4 and ectopic fat deposition.
abstract: OBJECTIVE
  To determine whether nonobese adolescents with polycystic ovary syndrome (PCOS) have higher levels of retinol-binding protein 4 (RBP4) and ectopic fat than controls and whether RBP4 and ectopic fat correlate with comorbidities of metabolic disease.
  
  
  METHODS
  Cross-sectional case-control study.
  
  
  METHODS
  Pediatric clinical research center based in a quaternary care medical center.
  
  
  METHODS
  Twenty-four nonobese adolescents between the ages of 13 and 21 years, 13 with PCOS and 11 controls.
  
  
  METHODS
  Measurement of RBP4, insulin resistance, lipids, and body composition.
  
  
  METHODS
  Retinol-binding protein 4, reproductive and adrenal hormones, insulin resistance, intrahepatic and intramyocellular lipid levels, and visceral adipose tissue.
  
  
  RESULTS
  Adolescents with PCOS had higher intrahepatic lipid content and a statistical trend for higher RBP4 compared with controls. Retinol-binding protein 4 correlated with body fat, triglycerides, insulin resistance, and androgens but not intrahepatic lipid content; however, when adjusted for body fat, the correlation between RBP4 and triglycerides weakened to a statistical trend and was no longer statistically significant for the other measures.
  
  
  CONCLUSIONS
  This small preliminary study of nonobese adolescent girls suggests that RBP4 may be involved in the dyslipidemia associated with PCOS and that there may be an independent relationship between RBP4 and triglycerides but not between RBP4 and insulin resistance. Although intrahepatic lipid content was higher in PCOS, it did not correlate with RBP4, triglycerides, or insulin resistance.
authors.affiliation: Department of Pediatrics, Columbia University Medical Center, New York, New York 10032, USA. ahs32@columbia.edu
authors.forename: Aviva B
authors.initials: AB
authors.lastname: Sopher
authors.forename: Adrienne T
authors.initials: AT
authors.lastname: Gerken
authors.forename: William S
authors.initials: WS
authors.lastname: Blaner
authors.forename: Jeremy M
authors.initials: JM
authors.lastname: Root
authors.forename: Donald J
authors.initials: DJ
authors.lastname: McMahon
authors.forename: Sharon E
authors.initials: SE
authors.lastname: Oberfield
mesh_terms: D050156:Adipogenesis; D000293:Adolescent; D000367:Age Factors; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D005951:Glucose Tolerance Test; D006728:Hormones / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008099:Liver / Q000378:metabolism; D010865:Pilot Projects; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000378:metabolism* / Q000503:physiopathology; D054839:Retinol-Binding Proteins, Plasma / Q000032:analysis*; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D006728:Hormones; D007328:Insulin; C101326:RBP4 protein, human; D054839:Retinol-Binding Proteins, Plasma; D014280:Triglycerides