title: In vitro study of role of trace amount of Cu release from Cu-bearing stainless steel targeting for reduction of in-stent restenosis.
abstract: A novel 316L type Cu-bearing stainless steel was developed in present work, aiming at reducing the occurrence of the in-stent restenosis after implantations of coronary stents, through trace amount of Cu release from surface of the steel in body fluid. It was found that there was a trace amount of Cu released from the Cu-bearing steel in a simulated body fluid, with no cytotoxicity. All the in vitro experimental results proved that this Cu-bearing steel could not only inhibit the proliferation of vascular smooth muscle cells, reducing the formation of thrombosis, which are the main reasons for happening of the in-stent restenosis, but also promote the proliferation of vascular endothelial cells needed for the revascularization, showing that this novel steel is prospective to be a new material for manufacturing coronary stents with function of reducing the in-stent restenosis.
authors.affiliation: Institute of Metal Research, Chinese Academy of Sciences, 72 Wenhua Road, Shenyang 110016, China. lren@imr.ac.cn
authors.forename: Ling
authors.initials: L
authors.lastname: Ren
authors.forename: Lu
authors.initials: L
authors.lastname: Xu
authors.forename: Jingwen
authors.initials: J
authors.lastname: Feng
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhang
authors.forename: Ke
authors.initials: K
authors.lastname: Yang
mesh_terms: D000818:Animals; D001012:Aorta, Abdominal / Q000166:cytology; D001807:Blood Vessel Prosthesis; D001826:Body Fluids / Q000737:chemistry / Q000378:metabolism; D002478:Cells, Cultured; D003300:Copper / Q000032:analysis / Q000737:chemistry / Q000493:pharmacokinetics* / Q000502:physiology; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006083:Graft Occlusion, Vascular / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D006801:Humans; D055616:Microtechnology / Q000379:methods; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D032389:Myocytes, Smooth Muscle / Q000166:cytology / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D009994:Osmolar Concentration; D051381:Rats; D013193:Stainless Steel / Q000737:chemistry / Q000493:pharmacokinetics*; D015607:Stents; D014914:Whole Blood Coagulation Time
chemical_list: D013193:Stainless Steel; D003300:Copper