title: Odor-Dependent Hemodynamic Responses Measured with NIRS in the Main Olfactory Bulb of Anesthetized Rats.
abstract: In this study, we characterize the hemodynamic changes in the main olfactory bulb of anesthetized Sprague-Dawley (SD) rats with near-infrared spectroscopy (NIRS, ISS Imagent) during presentation of two different odorants. Odorants were presented for 10 seconds with clean air via an automatic odor stimulator. Odorants are: (i) plain air as a reference (Blank), (ii) 2-Heptanone (HEP), (iii) Isopropylbenzene (IB). Our results indicated that a plain air did not cause any change in the concentrations of oxygenated (Δ[HbO(2)]) and deoxygenated hemoglobin (Δ[Hbr]), but HEP and IB induced strong changes. Furthermore, these odor-specific changes had regional differences within the MOB. Our results suggest that NIRS technology might be a useful tool to identify of various odorants in a non-invasive manner using animals which has a superb olfactory system.
authors.affiliation: Department of Physiology, College of Medicine, Hallym University, Chuncheon 200-702, Korea.
authors.forename: Hyun Joo
authors.initials: HJ
authors.lastname: Lee
authors.forename: Yunjun
authors.initials: Y
authors.lastname: Nam
authors.forename: Chin Su
authors.initials: CS
authors.lastname: Koh
authors.forename: Changkyun
authors.initials: C
authors.lastname: Im
authors.forename: In Seok
authors.initials: IS
authors.lastname: Seo
authors.forename: Seungjin
authors.initials: S
authors.lastname: Choi
authors.forename: Hyung-Cheul
authors.initials: HC
authors.lastname: Shin