title: [A comparison and significance of plasma riboflavin levels in patients with esophageal squamous cell carcinoma versus Linzhou healthy migrants in Changzhi of Shanxi].
abstract: OBJECTIVE
  To study the relationship between plasma riboflavin levels and esophageal squamous cell carcinoma.
  
  
  METHODS
  We detected and compared plasma concentrations of riboflavin in patients with esophageal squamous cell carcinoma (ESCC) and immigrants of Linzhou living in Changzhi. Plasma riboflavin levels were quantified in 445 ESCC patients, 689 healthy control subjects and 347 immigrants of Linzhou living in Changzhi by using enzyme-linked immunosorbent assay.
  
  
  RESULTS
  The plasma riboflavin levels in patients with ESCC were significantly lower than those in the healthy controls and immigrants of Linzhou living in Changzhi [(731.69 ± 330.67) µg/L vs (1090.43 ± 445.08) µg/L, (731.69 ± 330.67) µg/L vs (897.58 ± 177.78) µg/L, respectively, all P < 0.05], and the plasma riboflavin levels of the healthy controls were higher than those in the immigrants of Linzhou living in Changzhi (P < 0.05).
  
  
  CONCLUSIONS
  Patients with ESCC have decreased plasma riboflavin levels as compared with the healthy controls and immigrants of Linzhou living in Changzhi, there exists a lack of riboflavin in ESCC patients, but the specific mechanism needs further study.
authors.affiliation: Changzhi Medical University, Changzhi, Shanxi Province, China.
authors.forename: Ai-fang
authors.initials: AF
authors.lastname: Ji
authors.forename: Wu
authors.initials: W
authors.lastname: Wei
authors.forename: Jin-sheng
authors.initials: JS
authors.lastname: Wang
authors.forename: Zi-bai
authors.initials: ZB
authors.lastname: Wei
authors.forename: Chang-hong
authors.initials: CH
authors.lastname: Lian
authors.forename: Jian-zhou
authors.initials: JZ
authors.lastname: Yang
authors.forename: Li
authors.initials: L
authors.lastname: Zhao
authors.forename: Liang
authors.initials: L
authors.lastname: Ma
authors.forename: Li
authors.initials: L
authors.lastname: Ma
authors.forename: Xiao-qi
authors.initials: XQ
authors.lastname: Qin
authors.forename: Xiao-feng
authors.initials: XF
authors.lastname: He
authors.forename: Li-dong
authors.initials: LD
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000097:blood*; D016022:Case-Control Studies; D002681:China; D054242:Emigrants and Immigrants; D004938:Esophageal Neoplasms / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012256:Riboflavin / Q000097:blood*
chemical_list: D012256:Riboflavin