title: Estimating the prevalence and incidence of multiple sclerosis in the Lorraine region, France, by the capture-recapture method.
abstract: OBJECTIVE
  The objective of this study was to assess the prevalence and incidence of multiple sclerosis (MS) in the Lorraine region, in France.
  
  
  METHODS
  Data from three sources - Regional Health Insurance System, medical records departments and the Lorraine registry of MS - and a capture-recapture method with log-linear models were used to estimate the prevalence and incidence of MS.
  
  
  RESULTS
  We identified 7193 records of reported MS corresponding to 4299 unique suspected cases of MS existing on 31 December 2008, in Lorraine. On the basis of the 4001 validated cases, the observed crude prevalence of MS was 170.9 cases per 100,000 inhabitants (95% confidence interval [CI]: 165.7; 176.3), and the observed annual crude incidence of MS was 4.4 cases per 100,000 inhabitants (95% CI: 3.6; 5.4). With the capture-recapture method, the estimated prevalence of MS was 4405.7 (95% CI: 4261.5; 4629.7), so an estimated 405 cases were not identified by the three sources. The estimated prevalence was 188.2 cases per 100,000 inhabitants (95% CI: 182.7; 193.8), and the estimated annual incidence was 8.5 cases per 100,000 inhabitants (95% CI: 7.3; 9.7).
  
  
  CONCLUSIONS
  The capture-recapture method allowed us to estimate an additional 10.1% of unobserved prevalent cases and to anticipate 47.5% of unobserved incident cases.
authors.affiliation: Nancy University Hospital - Clinical Epidemiology and Evaluation, France.
authors.forename: Haritina
authors.initials: H
authors.lastname: El Adssi
authors.forename: Marc
authors.initials: M
authors.lastname: Debouverie
authors.forename: Francis
authors.initials: F
authors.lastname: Guillemin
mesh_terms: D000328:Adult; D017668:Age of Onset; D016009:Chi-Square Distribution; D015340:Epidemiologic Research Design; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000453:epidemiology*; D015995:Prevalence; D012042:Registries; D013997:Time Factors; D055815:Young Adult