title: Photoselective vaporization of the prostate with GreenLight 120-W laser compared with monopolar transurethral resection of the prostate: a multicenter randomized controlled trial.
abstract: BACKGROUND
  Evidence supporting the widespread use of GreenLight High Performance System (HPS) 120-W photoselective vaporization of the prostate (PVP) is lacking.
  
  
  OBJECTIVE
  To assess the noninferiority of PVP compared with transurethral resection of the prostate (TURP) on urinary symptoms and the superiority of PVP over TURP on length of hospital stay.
  
  
  METHODS
  A multicenter randomized controlled trial was conducted.
  
  
  METHODS
  Patients underwent monopolar TURP or PVP with the GreenLight HPS 120-W laser.
  
  
  METHODS
  International Prostate Symptom Score (IPSS), Euro-QOL questionnaire, uroflowmetry, Danish Prostate Symptom Score Sexual Function Questionnaire, sexual satisfaction, and adverse events were collected at 1, 3, 6, and 12 mo. The two groups were compared using the 95% confidence interval (CI) of median difference for testing noninferiority of the IPSS at 12 mo and the student t test for testing the difference in length of hospital stay.
  
  
  CONCLUSIONS
  A total of 139 patients (70 vs 69 men in each group) were randomized. Median IPSS scores at 12-mo follow-up were 5 (interquartile range [IQR]: 3-8) for TURP versus 6 (IQR: 3-9) for PVP, and the 95% CI of the difference of the median was equal to -2 to 3. Because the upper limit of the 95% CI was >2 (the noninferiority margin), the hypothesis of noninferiority could not be considered demonstrated. Median length of stay was significantly shorter in the PVP group than in the TURP group, with a median of 1 (IQR: 1-2) versus 2.5 (IQR: 2-3.5), respectively (p<0.0001). Uroflowmetry parameters and complications were comparable in both groups. Sexual outcomes were slightly better in the PVP group without reaching statistical significance.
  
  
  CONCLUSIONS
  The present study failed to demonstrate the noninferiority of 120-W GreenLight PVP versus TURP on prostate symptoms at 1 yr but showed that PVP was associated with a shorter length of stay in the hospital.
  
  
  BACKGROUND
  NCT01043588.
authors.affiliation: Department of Urology, Tenon Hospital, Assistance publique Hôpitaux de Paris; University Paris VI, Paris, France. bertrand.lukacs@tnn.aphp.fr
authors.forename: Bertrand
authors.initials: B
authors.lastname: Lukacs
authors.forename: Joyce
authors.initials: J
authors.lastname: Loeffler
authors.forename: Franck
authors.initials: F
authors.lastname: Bruyère
authors.forename: Pascal
authors.initials: P
authors.lastname: Blanchet
authors.forename: Albert
authors.initials: A
authors.lastname: Gelet
authors.forename: Patrick
authors.initials: P
authors.lastname: Coloby
authors.forename: Alexandre
authors.initials: A
authors.lastname: De la Taille
authors.forename: Philippe
authors.initials: P
authors.lastname: Lemaire
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Baron
authors.forename: Jean-Nicolas
authors.initials: JN
authors.lastname: Cornu
authors.forename: Mounir
authors.initials: M
authors.lastname: Aout
authors.forename: Helene
authors.initials: H
authors.lastname: Rousseau
authors.forename: Eric
authors.initials: E
authors.lastname: Vicaut
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016009:Chi-Square Distribution; D004867:Equipment Design; D005602:France; D006801:Humans; D053685:Laser Therapy / Q000009:adverse effects / Q000295:instrumentation*; D007834:Lasers; D007902:Length of Stay; D059411:Lower Urinary Tract Symptoms / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D011470:Prostatic Hyperplasia / Q000150:complications / Q000473:pathology / Q000601:surgery*; D012735:Sexual Dysfunction, Physiological / Q000175:diagnosis / Q000209:etiology; D011795:Surveys and Questionnaires; D013997:Time Factors; D020728:Transurethral Resection of Prostate / Q000009:adverse effects; D016896:Treatment Outcome; D014555:Urination Disorders / Q000175:diagnosis / Q000209:etiology; D014563:Urodynamics