title: Pd-catalysed synthesis of isoquinolinones and analogues via C-H and N-H bonds double activation.
abstract: An atom economical synthesis of isoquinolinones and analogues via ligand-free Pd-catalysed C-H and N-H double activation has been developed. A series of isoquinolinones were obtained in good to excellent yields. Good regioselectivities were also observed during the activation reactions with unsymmetrical alkynes. A practical one-pot procedure for the preparation of N-H isoquinolinones is also described.
authors.affiliation: Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China.
authors.forename: Hongban
authors.initials: H
authors.lastname: Zhong
authors.forename: Dan
authors.initials: D
authors.lastname: Yang
authors.forename: Songqing
authors.initials: S
authors.lastname: Wang
authors.forename: Jianhui
authors.initials: J
authors.lastname: Huang
mesh_terms: D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D007546:Isoquinolines; D009942:Organometallic Compounds; D010165:Palladium