title: In vitro activity of the new fluoroketolide solithromycin (CEM-101) against a large collection of clinical Neisseria gonorrhoeae isolates and international reference strains, including those with high-level antimicrobial resistance: potential treatment option for gonorrhea?
abstract: Gonorrhea may become untreatable, and new treatment options are essential. We investigated the in vitro activity of the first fluoroketolide, solithromycin. Clinical Neisseria gonorrhoeae isolates and reference strains (n = 246), including the two extensively drug-resistant strains H041 and F89 and additional isolates with clinical cephalosporin resistance and multidrug resistance, were examined. The activity of solithromycin was mainly superior to that of other antimicrobials (n = 10) currently or previously recommended for gonorrhea treatment. Solithromycin might be an effective treatment option for gonorrhea.
authors.affiliation: WHO Collaborating Centre for Gonorrhoea and other STIs, National Reference Laboratory for Pathogenic Neisseria, Department of Laboratory Medicine, Microbiology, Örebro University Hospital, Örebro, Sweden. magnus.unemo@orebroll.se
authors.forename: Daniel
authors.initials: D
authors.lastname: Golparian
authors.forename: Prabhavathi
authors.initials: P
authors.lastname: Fernandes
authors.forename: Makoto
authors.initials: M
authors.lastname: Ohnishi
authors.forename: Jörgen S
authors.initials: JS
authors.lastname: Jensen
authors.forename: Magnus
authors.initials: M
authors.lastname: Unemo
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D018550:Cephalosporin Resistance; D002511:Cephalosporins / Q000494:pharmacology; D003470:Culture Media; D024901:Drug Resistance, Multiple, Bacterial / Q000187:drug effects; D004917:Erythromycin / Q000494:pharmacology; D006801:Humans; D018942:Macrolides / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009344:Neisseria gonorrhoeae / Q000187:drug effects* / Q000254:growth & development / Q000302:isolation & purification; D014230:Triazoles / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D003470:Culture Media; D018942:Macrolides; D014230:Triazoles; D004917:Erythromycin; C547755:solithromycin