title: [Loss of pan-T cell antigens CD2, CD3, CD5 and CD7 in Kikuchi's disease].
abstract: OBJECTIVE
  To study the possible loss of pan-T cell antigens CD2, CD3, CD5 and CD7 in Kikuchi's disease and to evaluate the role of T cell antigen loss in distinguishing benign from malignant T-cell lymphoid lesions.
  
  
  METHODS
  Formalin-fixed and paraffin-embedded tissues of 33 cases of Kikuchi's disease and 15 cases of reactive lymphoid hyperplasia were studied by EliVision immunohistochemical staining for CD2, CD3, CD5 and CD7.
  
  
  RESULTS
  Twenty-four of the 33 (72.7%) cases of Kikuchi's disease lost one or more of the pan-T cell antigens, including the loss of CD5 only (13 cases), CD7 only (1 case), CD2 only (1 case), CD2 and CD7 (2 cases), CD5 and CD7 (4 cases), CD2 and CD5 (2 cases), and CD2, CD7 and CD5 (1 case). Amongst these cases, the commonest antigen loss was CD5 (20 cases, 60.6%), followed by CD7 (8 cases, 24.2%) and CD2 (6 cases, 18.2%). Compared with the xanthomatous subtype of Kikuchi's disease, the loss of antigens was more commonly seen in the proliferative and necrotizing subtypes. Analysis of follow-up data showed that the loss of antigens in Kikuchi's disease was not significantly associated with the prognosis. In reactive lymphoid hyperplasia, the expression of CD2, CD3, CD5 and CD7 was seen in all cases with similar intensity, with no obvious pan-T cell antigen loss.
  
  
  CONCLUSIONS
  Loss of one or more pan-T cell antigens in Kikuchi's disease is demonstrated in present study, suggesting that the immunophenotypic pattern is not unique in T cell lymphoma.
authors.affiliation: Department of Pathology, Capital Medical University, Beijing, China.
authors.forename: Xue-jing
authors.initials: XJ
authors.lastname: Wei
authors.forename: Jian-lan
authors.initials: JL
authors.lastname: Xie
authors.forename: Xiao-ge
authors.initials: XG
authors.lastname: Zhou
authors.forename: Xiao-dan
authors.initials: XD
authors.lastname: Zheng
authors.forename: Yuan-yuan
authors.initials: YY
authors.lastname: Zheng
authors.forename: Yan
authors.initials: Y
authors.lastname: Jin
authors.forename: Hong
authors.initials: H
authors.lastname: Zhu
authors.forename: Yan-ning
authors.initials: YN
authors.lastname: Zhang
authors.forename: Shu-hong
authors.initials: SH
authors.lastname: Zhang
authors.forename: Guang-Yong
authors.initials: GY
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D019011:Antigens, CD7 / Q000378:metabolism; D018801:CD2 Antigens / Q000378:metabolism; D017252:CD3 Complex / Q000378:metabolism; D018956:CD5 Antigens / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D020042:Histiocytic Necrotizing Lymphadenitis / Q000276:immunology* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D019310:Pseudolymphoma / Q000276:immunology; D012008:Recurrence; D013601:T-Lymphocytes / Q000276:immunology*; D055815:Young Adult
chemical_list: D019011:Antigens, CD7; D018801:CD2 Antigens; D017252:CD3 Complex; D018956:CD5 Antigens