title: Secretive bacterial pathogens and the secretory pathway.
abstract: Eukaryotic cells possess two extensive endomembrane systems, each consisting of several sub-compartments connected by vesicular trafficking. One of these systems, the endocytic pathway, serves incoming traffic, and the other system, the secretory pathway (SP), is responsible for surface-bound traffic of intracellularly formed vesicles. Compartments derived of either system can be colonized by intracellular pathogens. In this review, we discuss the interactions between the SP and prominent intracellular bacterial pathogens of the genera Legionella, Brucella, Chlamydia and Salmonella. We emphasize secreted bacterial effector proteins, which directly manipulate host components of this pathway.
authors.affiliation: Max von Pettenkofer Institute, Ludwig-Maximilians University, Pettenkoferstraße 9a, Munich, 80336, Germany. hilbi@mvp.uni-muenchen.de
authors.forename: Hubert
authors.initials: H
authors.lastname: Hilbi
authors.forename: Albert
authors.initials: A
authors.lastname: Haas
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000378:metabolism; D002002:Brucella / Q000737:chemistry / Q000472:pathogenicity*; D002689:Chlamydia / Q000737:chemistry / Q000472:pathogenicity*; D011992:Endosomes / Q000378:metabolism; D005057:Eukaryotic Cells / Q000382:microbiology; D054884:Host-Pathogen Interactions; D006801:Humans; D007875:Legionella / Q000737:chemistry / Q000472:pathogenicity*; D021381:Protein Transport; D012475:Salmonella / Q000737:chemistry / Q000472:pathogenicity*; D055571:Secretory Pathway
chemical_list: D001426:Bacterial Proteins