title: Immunogold probes in electron microscopy.
abstract: Electron microscopy permits the detailed study of cell relationships within tissues and organelles within cells. Electron immunocytochemistry is the high resolution study of antigens within cells and their relation to cell ultrastructure. Fixation to achieve optimal fine structural detail for electron microscopy is exactly that which damages antigens with respect to reaction with specific antibody. Cell preparation for electron microscopy is therefore a compromise between retaining sufficient antigenicity while preserving the cell ultrastructure.
authors.affiliation: Wellcome Research Laboratories, Beckenham, UK.
authors.forename: J E
authors.initials: JE
authors.lastname: Beesley