title: Prognostic and therapeutic role of nuclear factor-kappa B (NF-kappaB) in breast cancer.
abstract: Nuclear Factor- kappa B (NF-kappaB) is an essential transcription factor that not only modulates cellular responses to stress but also plays a pivotal role in inflammation, immunity, cell cycle growth and survival. NF-kappaB-regulated genes have been documented to be involved in cellular proliferation and invasion along with tumour related angiogenesis and lymphangiogenesis. Dysregulation of NF-kappaB associated pathways are seen in multiple malignancies. Its constitutive activation in the clinically aggressive and prognostically poor ER-negative, Her2-neu positive and inflammatory breast cancer could formulate the basis for its evolution as a potential prognostic and therapeutic target.
authors.affiliation: Department of Pathology, College of Medicine, University of Dammam, Dammam, Kingdom of Saudi Arabia. ayesash@hotmail.com
authors.forename: Ayesha
authors.initials: A
authors.lastname: Ahmed
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D016328:NF-kappa B / Q000494:pharmacology*; D009362:Neoplasm Metastasis / Q000188:drug therapy; D011379:Prognosis
chemical_list: D016328:NF-kappa B