title: Phantom model of physiologic intracranial pressure and cerebrospinal fluid dynamics.
abstract: We describe herein a novel life-size phantom model of the intracranial cavity and its validation. The cerebrospinal fluid (CSF) domains including ventricular, cysternal, and subarachnoid spaces were derived via magnetic resonance imaging. Brain mechanical properties and cranio-spinal compliance were set based on published data. Both bulk and pulsatile physiologic CSF flow were modeled. Model validation was carried out by comparisons of flow and pressure measurements in the phantom with published in vivo data of healthy subjects. Physiologic intracranial pressure with 10 mmHg mean and 0.4 mmHg peak pulse amplitude was recorded in the ventricles. Peak CSF flow rates of 0.2 and 2 ml/s were measured in the cerebral aqueduct and subarachnoid space, respectively. The phantom constitutes a first-of-its-kind approach to modeling physiologic intracranial dynamics in vitro. Herein, we describe the phantom design and manufacturing, definition and implementation of its operating parameters, as well as the validation of the modeled dynamics.
authors.affiliation: Laboratory of Thermodynamics in Emerging Technologies, Department of Mechanical and Process Engineering, ETH Zurich, Zurich 8092, Switzerland. bottans@ethz.ch
authors.forename: Simone
authors.initials: S
authors.lastname: Bottan
authors.forename: Dimos
authors.initials: D
authors.lastname: Poulikakos
authors.forename: Vartan
authors.initials: V
authors.lastname: Kurtcuoglu
mesh_terms: D040761:Biomimetic Materials; D001921:Brain / Q000033:anatomy & histology* / Q000502:physiology*; D002555:Cerebrospinal Fluid / Q000502:physiology*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D007427:Intracranial Pressure / Q000502:physiology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D019047:Phantoms, Imaging