title: Update on the frequency of Ile1016 mutation in voltage-gated sodium channel gene of Aedes aegypti in Mexico.
abstract: We analyzed 790 Aedes aegypti from 14 localities of Mexico in 2009 to update information on the frequency of the Ile1016 allele in the voltage-gated sodium channel gene that confers resistance to pyrethroids and DDT. The Ile1016 mutation was present in all 17 collections, and was close to fixation in Acapulco (frequency = 0.97), Iguala (0.93), and San Nicolas (0.90). Genotypes at the 1016 locus were not in Hardy-Weinberg proportions in collections from Panuco, Veracruz, Cosoleacaque, Coatzacoalcos, Tantoyuca, and Monterrey due in every case to an excess of homozygotes. The high frequencies of this mutation in Ae. aegypti are probably due to selection pressure from pyrethroid insecticides, particularly permethrin, which has been used in mosquito control programs for >10 years in Mexico.
authors.affiliation: Laboratorio de Entomología Medica, Facultad de Ciencias Biológicas, Universidad Autónoma de Nuevo León, 66451 Mexico.
authors.forename: Quetzaly
authors.initials: Q
authors.lastname: Siller
authors.forename: Gustavo
authors.initials: G
authors.lastname: Ponce
authors.forename: Saul
authors.initials: S
authors.lastname: Lozano
authors.forename: Adriana E
authors.initials: AE
authors.lastname: Flores
mesh_terms: D000330:Aedes / Q000235:genetics* / Q000502:physiology*; D000818:Animals; D003710:Demography; D005786:Gene Expression Regulation / Q000502:physiology*; D005838:Genotype; D019476:Insect Proteins / Q000235:genetics / Q000378:metabolism*; D007305:Insecticide Resistance; D007306:Insecticides / Q000494:pharmacology; D015640:Ion Channel Gating / Q000235:genetics*; D008800:Mexico; D009154:Mutation; D011722:Pyrethrins / Q000494:pharmacology; D015222:Sodium Channels / Q000235:genetics* / Q000378:metabolism
chemical_list: D019476:Insect Proteins; D007306:Insecticides; D011722:Pyrethrins; D015222:Sodium Channels