title: Promoter methylation in head and neck tumorigenesis.
abstract: In addition to genetic alterations of gains and losses, epigenetic events of promoter methylation appear to further undermine a destabilized genomic repertoire in squamous head and neck carcinoma (HNSCC). This chapter provides an overview of frequently methylated tumor suppressor genes in benign head and neck papillomas, primary HNSCC tumors, and HNSCC cell lines and their relevance as epigenetic markers in head and neck tumorigenesis.
authors.affiliation: Department of Otolaryngology/Head and Neck Surgery, Henry Ford Hospital, Detroit, MI, USA.
authors.forename: Josena K
authors.initials: JK
authors.lastname: Stephen
authors.forename: Kang Mei
authors.initials: KM
authors.lastname: Chen
authors.forename: Shaleta
authors.initials: S
authors.lastname: Havard
authors.forename: Glynis
authors.initials: G
authors.lastname: Harris
authors.forename: Maria J
authors.initials: MJ
authors.lastname: Worsham
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D045744:Cell Line, Tumor; D002471:Cell Transformation, Neoplastic / Q000235:genetics / Q000378:metabolism*; D019175:DNA Methylation / Q000235:genetics / Q000502:physiology*; D015342:DNA Probes; D044127:Epigenesis, Genetic; D016147:Genes, Tumor Suppressor; D006258:Head and Neck Neoplasms / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D011401:Promoter Regions, Genetic / Q000235:genetics*; D060888:Real-Time Polymerase Chain Reaction
chemical_list: D014408:Biomarkers, Tumor; D015342:DNA Probes