title: Highly chemoselective reduction of carbonyl groups in the presence of aldehydes.
abstract: The exquisite ability of diethylaluminum benzenethiolate to efficiently discriminate between aldehydes and other carbonyl functions enables the chemoselective in situ reduction of ketones and methyl esters in the presence of aldehydes. This potent strategy avoids the usual drawbacks of traditional protecting group methodologies and could be extended to various other transformations.
authors.affiliation: Université Catholique de Louvain, Laboratory of Organic and Medicinal Chemistry, Bâtiment Lavoisier, Place Louis Pasteur 1 bte L4.01.02., B-1348 Louvain-la-Neuve, Belgium.
authors.forename: Gulluzar
authors.initials: G
authors.lastname: Bastug
authors.forename: Steve
authors.initials: S
authors.lastname: Dierick
authors.forename: Frédéric
authors.initials: F
authors.lastname: Lebreux
authors.forename: István E
authors.initials: IE
authors.lastname: Markó
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction
chemical_list: D000447:Aldehydes; D007659:Ketones