title: [The diagnostic value of RNA oncomarkers in evaluation of malignant breast tumors].
abstract: The levels of the RNA oncomarkers, telomerase (hTERT), cytokeratin-19 (CK-19) and mammaglobin (MAM) have been investigated in capillary blood of female patients with mammary ductal carcinoma. The study revealed overexpression of all three factors in patients with this pathology. This overexpression was not found in healthy donors and female patients with mammary fibroadenoma. Levels of the RNA oncomarkers return to the normal level within 10 days after successful tumor resection. These results have been used for the development of diagnostic kits, which may be applicable for differential diagnostics, screening and postoperation monitoring of patients with malignant breast tumors
authors.forename: A G
authors.initials: AG
authors.lastname: Globa
authors.forename: Ia I
authors.initials: IaI
authors.lastname: Alekseev
authors.forename: D A
authors.initials: DA
authors.lastname: Varlamov
authors.forename: A A
authors.initials: AA
authors.lastname: Vishnevskiĭ
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood* / Q000235:genetics; D001943:Breast Neoplasms / Q000097:blood* / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000097:blood* / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D018226:Fibroadenoma / Q000097:blood* / Q000601:surgery; D006801:Humans; D053539:Keratin-19 / Q000097:blood / Q000235:genetics; D060785:Mammaglobin A / Q000097:blood; D011237:Predictive Value of Tests; D012334:RNA, Neoplasm / Q000097:blood* / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D019098:Telomerase / Q000097:blood / Q000235:genetics
chemical_list: D014408:Biomarkers, Tumor; D053539:Keratin-19; D060785:Mammaglobin A; D012334:RNA, Neoplasm; C509186:TERT protein, human; D019098:Telomerase