title: In situ hetero end-functionalized polythiophene and subsequent "click" chemistry with DNA.
abstract: It is demonstrated that bifunctionalized polythiophenes involving thiol and azide end-functional groups can be synthesized by chain-growth Suzuki-Miyaura type polymerization. The bifunctionalized polythiophenes are successfully characterized by 1H NMR, gel permeation chromatography (GPC), and matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF). Furthermore, the azide end-group reacts with DNA via "click chemistry" to form a polythiophene/DNA hybrid structure, which is characterized by ESI-MS. The described synthetic approaches will lead to the synthesis of novel multi-block copolymers as well as biomolecule-based conjugated polymer structures.
authors.affiliation: Department of Chemistry, Stanford University, Stanford, CA 94305, USA.
authors.forename: Jungkyu K
authors.initials: JK
authors.lastname: Lee
authors.forename: Sangwon
authors.initials: S
authors.lastname: Ko
authors.forename: Zhenan
authors.initials: Z
authors.lastname: Bao
mesh_terms: D001386:Azides; D002850:Chromatography, Gel; D057930:Click Chemistry; D004247:DNA / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D058105:Polymerization; D011108:Polymers / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013876:Thiophenes / Q000737:chemistry*
chemical_list: D001386:Azides; D011108:Polymers; D013876:Thiophenes; C066730:polythiophene; D004247:DNA