title: Resveratrol in cancer: cellular and mitochondrial consequences of proton transport inhibition.
abstract: Transformed cells suffer several changes leading to the increase of protective mechanisms and show a metabolic profile in accordance with higher proliferative capacity. In these mechanisms, changes in mitochondrial activity cause a higher glycolytic metabolism in detriment of oxidative phosphorylation. In these changes, H⁺-ATPase regulation seems to be importantly involved. During the last years, polyphenols and specially the stilbene resveratrol and related members of its family have been studied because they are able to affect tumour cell growth and cancer progression. Among the different effects induced by resveratrol, inhibition of H⁺-ATPase seems to be one important mechanism in its effect on cancer progression. Further, an ectopic H⁺-ATPase located in the outer surface of plasma membrane has been recently involved in cancer progression and angiogenesis. In this article we review the latest findings about resveratrol inhibition of H⁺-ATPase and its importance in tumour cell growth and cancer progression.
authors.affiliation: Centro Andaluz de Biologia del Desarrollo, Universidad Pablo de Olavide, Carretera de Utrera Km. 1, 41013 Sevilla, Spain. glopllu@upo.es
authors.forename: Guillermo
authors.initials: G
authors.lastname: Lopez-Lluch
authors.forename: Sara Santa
authors.initials: SS
authors.lastname: Cruz-Calvo
authors.forename: Placido
authors.initials: P
authors.lastname: Navas
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D006180:Proton-Translocating ATPases / Q000378:metabolism; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D013267:Stilbenes; D006180:Proton-Translocating ATPases; D000077185:Resveratrol