title: Seizures and epilepsy in Sotos syndrome: analysis of 19 Caucasian patients with long-term follow-up.
abstract: Sotos syndrome (SS) is an overgrowth syndrome characterized by typical facial appearance, learning disability, and macrocephaly as cardinal diagnostic features. Febrile (FS) and afebrile seizures are reported in 9-50% of cases. There is no evidence that patients with SS and FS later develop epilepsy, and no studies have investigated the electroclinical features and the long-term outcome in epileptic SS patients. The authors report a series of 19 SS patients with FS and/or epilepsy during childhood and a long-term follow-up. More than half of FS evolved to epilepsy. Temporal lobe seizures were recorded in 40% of patients with SS. Seizures were easy to control with common antiepileptic drugs in almost all patients. A careful neurologic evaluation is useful for SS patients, since seizures are an important finding among people with this overgrowth syndrome.
authors.affiliation: Child Neurology Division, Department of Pediatrics, Policlinico Umberto I, Sapienza University of Rome, Roma, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Nicita
authors.forename: Martino
authors.initials: M
authors.lastname: Ruggieri
authors.forename: Agata
authors.initials: A
authors.lastname: Polizzi
authors.forename: Laura
authors.initials: L
authors.lastname: Mauceri
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Salpietro
authors.forename: Silvana
authors.initials: S
authors.lastname: Briuglia
authors.forename: Laura
authors.initials: L
authors.lastname: Papetti
authors.forename: Fabiana
authors.initials: F
authors.lastname: Ursitti
authors.forename: Salvatore
authors.initials: S
authors.lastname: Grosso
authors.forename: Luigi
authors.initials: L
authors.lastname: Tarani
authors.forename: Maria
authors.initials: M
authors.lastname: Segni
authors.forename: Salvatore
authors.initials: S
authors.lastname: Savasta
authors.forename: Pasquale
authors.initials: P
authors.lastname: Parisi
authors.forename: Alberto
authors.initials: A
authors.lastname: Verrotti
authors.forename: Alberto
authors.initials: A
authors.lastname: Spalice
mesh_terms: D000293:Adolescent; D002648:Child; D004827:Epilepsy / Q000209:etiology*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D012189:Retrospective Studies; D012640:Seizures / Q000209:etiology*; D058495:Sotos Syndrome / Q000150:complications*; D044465:White People; D055815:Young Adult