title: Comparison of complications and outcomes to one year of transcatheter aortic valve implantation versus surgical aortic valve replacement in patients with severe aortic stenosis.
abstract: Comparisons of transcatheter aortic valve implantation (TAVI) to surgical aortic valve replacement (SAVR) in patients with severe aortic stenosis remain sparse or limited by a short follow-up. We sought to evaluate early and midterm outcomes of consecutive patients (n = 618) undergoing successful TAVI (n = 218) or isolated SAVR (n = 400) at 2 centers. The primary end point was incidence of Valvular Academic Research Consortium-defined major adverse cerebrovascular and cardiac events (MACCEs) up to 1 year. Control of potential confounders was attempted with extensive statistical adjustment by covariates and/or propensity score. In-hospital MACCEs occurred in 73 patients (11.8%) and was more frequent in patients treated with SAVR compared to those treated with TAVI (7.8% vs 14.0%, p = 0.022). After addressing potential confounders using 3 methods of statistical adjustment, SAVR was consistently associated with a higher risk of MACCEs than TAVI, with estimates of relative risk ranging from 2.2 to 2.6 at 30 days, 2.3 to 2.5 at 6 months, and 2.0 to 2.2 at 12 months. This difference was driven by an adjusted increased risk of life-threatening bleeding at 6 and 12 months and stroke at 12 months with SAVR. Conversely, no differences in adjusted risk of death, stroke and myocardial infarction were noted between TAVI and SAVR at each time point. In conclusion, in a large observational registry with admitted potential for selection bias and residual confounding, TAVI was not associated with a higher risk of 1-year MACCEs compared to SAVR.
authors.affiliation: Division of Cardiology, Ferrarotto Hospital, University of Catania, Italy.
authors.forename: Corrado
authors.initials: C
authors.lastname: Tamburino
authors.forename: Marco
authors.initials: M
authors.lastname: Barbanti
authors.forename: Davide
authors.initials: D
authors.lastname: Capodanno
authors.forename: Carmelo
authors.initials: C
authors.lastname: Mignosa
authors.forename: Maurizio
authors.initials: M
authors.lastname: Gentile
authors.forename: Patrizia
authors.initials: P
authors.lastname: Aruta
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Pistritto
authors.forename: Claudio
authors.initials: C
authors.lastname: Bonanno
authors.forename: Salvatore
authors.initials: S
authors.lastname: Bonura
authors.forename: Alessandra
authors.initials: A
authors.lastname: Cadoni
authors.forename: Simona
authors.initials: S
authors.lastname: Gulino
authors.forename: Maria Concetta
authors.initials: MC
authors.lastname: Di Pasqua
authors.forename: Valeria
authors.initials: V
authors.lastname: Cammalleri
authors.forename: Marilena
authors.initials: M
authors.lastname: Scarabelli
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Mulè
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Immè
authors.forename: Giuliana
authors.initials: G
authors.lastname: Del Campo
authors.forename: Gian Paolo
authors.initials: GP
authors.lastname: Ussia
mesh_terms: D000368:Aged; D001024:Aortic Valve Stenosis / Q000175:diagnosis / Q000601:surgery*; D006328:Cardiac Catheterization; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D019918:Heart Valve Prosthesis Implantation / Q000379:methods*; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D008297:Male; D011183:Postoperative Complications / Q000453:epidemiology*; D012307:Risk Factors; D012720:Severity of Illness Index; D015996:Survival Rate / Q000639:trends; D013997:Time Factors; D016896:Treatment Outcome