title: The FLT3 and Pim kinases inhibitor SGI-1776 preferentially target FLT3-ITD AML cells.
authors.forename: Marie-Anne
authors.initials: MA
authors.lastname: Hospital
authors.forename: Alexa S
authors.initials: AS
authors.lastname: Green
authors.forename: Catherine
authors.initials: C
authors.lastname: Lacombe
authors.forename: Patrick
authors.initials: P
authors.lastname: Mayeux
authors.forename: Didier
authors.initials: D
authors.lastname: Bouscary
authors.forename: Jerome
authors.initials: J
authors.lastname: Tamburini
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D045744:Cell Line, Tumor; D004353:Drug Evaluation, Preclinical; D020440:Gene Duplication; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology / Q000627:therapeutic use*; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism; D058990:Molecular Targeted Therapy; D050505:Mutant Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry; D009154:Mutation / Q000502:physiology; D047428:Protein Kinase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D017434:Protein Structure, Tertiary / Q000235:genetics; D051573:Proto-Oncogene Proteins c-pim-1 / Q000037:antagonists & inhibitors*; D011724:Pyridazines / Q000494:pharmacology / Q000627:therapeutic use*; D013379:Substrate Specificity / Q000235:genetics; D020080:Tandem Repeat Sequences / Q000235:genetics; D051941:fms-Like Tyrosine Kinase 3 / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000235:genetics*
chemical_list: D000970:Antineoplastic Agents; D007093:Imidazoles; D050505:Mutant Proteins; D047428:Protein Kinase Inhibitors; D011724:Pyridazines; C545188:SGI 1776; C497970:FLT3 protein, human; D051941:fms-Like Tyrosine Kinase 3; D051573:Proto-Oncogene Proteins c-pim-1; C406031:proto-oncogene proteins pim