title: Role of the hyaluronan-producing tenosynovium in preventing adhesion formation during healing of flexor tendon injuries.
abstract: Flexor tendons of white Leghorn chickens (n = 25) were used for this study. One chicken was used as a normal control (no surgery), and the remaining 24 were used for experiments. After partial tendon-severing in both legs of 24 chickens, the right and the left leg were treated differently, thereby creating two groups: Group I, in which the tenosynovium was preserved, and Group II, in which the tenosynovium was removed. Hematoxylin-eosin staining was performed to observe adhesions; immunohistochemical analysis was used to localize HA. HA production was noted in granulation tissue invading between the tendon stumps in both groups; however, HA expression in the tenosynovium was observed only in Group I where adhesion formation was minimal. The HA-producing tenosynovium plays a crucial role in preventing adhesion formation in this model of flexor tendon injuries.
authors.affiliation: Department of Orthopaedic Surgery, Kurume University, Fukuoka 830-0011, Japan.
authors.forename: Masaharu
authors.initials: M
authors.lastname: Yagi
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Mitsui
authors.forename: Masafumi
authors.initials: M
authors.lastname: Gotoh
authors.forename: Naoto
authors.initials: N
authors.lastname: Sato
authors.forename: Kenji
authors.initials: K
authors.lastname: Yoshida
authors.forename: Kensei
authors.initials: K
authors.lastname: Nagata
mesh_terms: D000818:Animals; D002645:Chickens; D004195:Disease Models, Animal; D006097:Granulation Tissue / Q000378:metabolism; D006801:Humans; D018960:Hyaluronan Receptors / Q000378:metabolism; D006820:Hyaluronic Acid / Q000378:metabolism*; D007150:Immunohistochemistry; D013583:Synovial Membrane / Q000378:metabolism*; D013708:Tendon Injuries / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D000267:Tissue Adhesions / Q000517:prevention & control; D014945:Wound Healing
chemical_list: D018960:Hyaluronan Receptors; D006820:Hyaluronic Acid