title: An efficient three component one-pot synthesis of 5-amino-7-aryl-7,8-dihydro-[1,2,4] triazolo[4,3-a]-pyrimidine-6-carbonitriles.
abstract: A series of novel 5-amino-7-aryl-7,8-dihydro-[1,2,4] triazolo[4,3-a]-pyrimidine-6-carbonitriles were synthesized by a one-pot reaction of 3-amino-1,2,4-triazole, malononitrile and aryl aldehydes in the presence of 20 mol% NaOH in ethanol under heating or ultrasonic irradiation. The structures of the target compounds were confirmed by inspection of their (1)H- NMR, (13)C-NMR, IR and MS spectra. The advantages of this method are short reaction times, good yields, high selectivity and operational simplicity.
authors.affiliation: College of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046, China. ablajan209@hotmail.com
authors.forename: Keyume
authors.initials: K
authors.lastname: Ablajan
authors.forename: Wetengul
authors.initials: W
authors.lastname: Kamil
authors.forename: Anagu
authors.initials: A
authors.lastname: Tuoheti
authors.forename: Sun
authors.initials: S
authors.lastname: Wan-Fu
mesh_terms: D009682:Magnetic Resonance Spectroscopy; D009570:Nitriles / Q000138:chemical synthesis* / Q000737:chemistry; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared
chemical_list: D009570:Nitriles