title: Effect of bis(7)-tacrine on cognition in rats with chronic cerebral ischemia.
abstract: Bis(7)-tacrine (B7T), a novel dimeric acetyl cholinesterase (AChE) inhibitor, has multiple neuroprotective activities against neuronal damage. However, its therapeutic effects in chronic cerebral ischemia remain unknown. In the present study, adult male Sprague-Dawley rats were subjected with permanent ligation of the bilateral common carotid arteries to investigate the roles of B7T on cognitive function, neuronal apoptosis and neurogenesis in the hippocampus. Results from spatial navigation test showed that chronic cerebral ischemia impaired spatial learning, B7T treatment shorten escape latency of ischemia rats as compared with saline-treated rats. Probe trial test indicated that spatial memory deficit of chronic cerebral ischemic animals was reversed by B7T treatment. Immunohistochemical results showed that B7T reduced neuronal apoptosis in the hippocampal CA1 region as compared with ischemia rats, and B7T treatment increased neurogenesis in the hippocampus. These findings suggest that B7T may exert its neuroprotective effects by inhibiting apoptosis and promoting neurogenesis in 2VO rats.
authors.affiliation: Department of Pathology and Pathophysiology, Medical School, Jianghan University, Wuhan 430056, Hubei, PR China.
authors.forename: Xi-Ji
authors.initials: XJ
authors.lastname: Shu
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Rong
authors.initials: R
authors.lastname: Yang
authors.forename: Hui-Ling
authors.initials: HL
authors.lastname: Yi
authors.forename: Chang-Lei
authors.initials: CL
authors.lastname: Li
authors.forename: Yan-Jie
authors.initials: YJ
authors.lastname: Ye
authors.forename: Yong-Xun
authors.initials: YX
authors.lastname: Ai
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002545:Brain Ischemia / Q000188:drug therapy* / Q000473:pathology; D002908:Chronic Disease; D003071:Cognition / Q000187:drug effects*; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D055495:Neurogenesis / Q000187:drug effects; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013619:Tacrine / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: C122128:1,7-N-heptylene-bis-9,9'-amino-1,2,3,4-tetrahydroacridine; D018696:Neuroprotective Agents; D013619:Tacrine