title: [Studies on the relationship between polymorphism of IL-28B rs8099917 and the outcome of HBV infection].
abstract: OBJECTIVE
  To investigate the correlation between IL-28B rs8099917 polymorphism and the outcome of HBV infection.
  
  
  METHODS
  Genotype of rs8099917 (T > G) in IL-28B locus was determined by TaqMan SNP genotyping from 486 individuals which including 199 chronic HBV carriers (including 100 HBV-induced liver cirrhosis and 99 HBV-related HCC). 143 people with self-limited infection and 144 healthy people served as controls. Multivariate analysis was used to assess the effect of IL-28B rs8099917 SNP among all the studied groups.
  
  
  RESULTS
  Distribution of genotype and allele of the rs8099917 locus were in accordance with Hardy-Weinberg equilibrium in different groups or with the total population. The frequencies of the rs8099917 TT, GT, GG genotypes were 89.3%, 10.5% and 0.2%, and the frequency of allele T and G accounted for 94.5% and 5.5%, respectively. In respect of genotype or allele frequency, there was no significant differences found among the groups (P > 0.05). When comparing with the TT genotype, data from the multinomial logistic analysis showed that the ORs and (95%CI) of TG/GG genotypes were 1.589 (0.735 - 3.437), 1.351 (0.550 - 3.316) and 1.704 (0.717 - 4.052), respectively. The genotype frequencies in different groups with different clinical features showed that TG/GG genotypes significantly increased the risk of r-GTII(+) for individuals with HBV-related HCC (χ(2) = 17.534, P = 0.001), with OR as 14.821 (3.227 - 68.064). It was particularly so for males (χ(2) = 14.924, P = 0.014), with OR (95%CI) as 45.000 (2.772 - 730.571).
  
  
  CONCLUSIONS
  IL-28B rs8099917 SNP had no correlation with the outcome of HBV infection.
authors.affiliation: Third Central Clinical College of Tianjin Medical University, Tianjin, China.
authors.forename: Xiao-lei
authors.initials: XL
authors.lastname: Jiao
authors.forename: Ying-tang
authors.initials: YT
authors.lastname: Gao
authors.forename: Li
authors.initials: L
authors.lastname: Jing
authors.forename: Tong
authors.initials: T
authors.lastname: Liu
authors.forename: Wen-xia
authors.initials: WX
authors.lastname: Shi
authors.forename: Hua
authors.initials: H
authors.lastname: Guo
authors.forename: Bin
authors.initials: B
authors.lastname: Yang
authors.forename: Zhi
authors.initials: Z
authors.lastname: DU
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D006509:Hepatitis B / Q000235:genetics*; D006801:Humans; D007372:Interferons; D007378:Interleukins / Q000235:genetics*; D008103:Liver Cirrhosis / Q000235:genetics; D008113:Liver Neoplasms / Q000235:genetics; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D000095022:Interferon Lambda
chemical_list: D007372:Interferons; D007378:Interleukins; C000624353:interferon-lambda, human; D000095022:Interferon Lambda