title: Wake-promoting agents: search for next generation modafinil: part II.
abstract: In search of a next generation molecule to modafinil, a novel wake promoting agent, we previously disclosed bi-phenyl derived racemate compound (±)-2 as a new generation of wake-promoting agent. Here we describe the profiles of the individual enantiomers (-)-2 and (+)-2, respectively.
authors.affiliation: Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380-4245, USA.
authors.forename: Derek
authors.initials: D
authors.lastname: Dunn
authors.forename: Greg
authors.initials: G
authors.lastname: Hostetler
authors.forename: Mohamed
authors.initials: M
authors.lastname: Iqbal
authors.forename: Patricia
authors.initials: P
authors.lastname: Messina-McLaughlin
authors.forename: Alyssa
authors.initials: A
authors.lastname: Reiboldt
authors.forename: Yin Guo
authors.initials: YG
authors.lastname: Lin
authors.forename: John
authors.initials: J
authors.lastname: Gruner
authors.forename: Edward R
authors.initials: ER
authors.lastname: Bacon
authors.forename: Mark A
authors.initials: MA
authors.lastname: Ator
authors.forename: Sankar
authors.initials: S
authors.lastname: Chatterjee
mesh_terms: D000818:Animals; D019540:Area Under Curve; D001713:Biphenyl Compounds / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D000697:Central Nervous System Stimulants / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004569:Electroencephalography; D007274:Injections, Intraperitoneal; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D000072516:Retinoic Acid 4-Hydroxylase; D012890:Sleep / Q000187:drug effects; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014851:Wakefulness / Q000187:drug effects* / Q000502:physiology
chemical_list: D001713:Biphenyl Compounds; D000697:Central Nervous System Stimulants; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System; D000072516:Retinoic Acid 4-Hydroxylase