title: [Endotoxinemia and systemic inflammation in pathogenesis of chronic heart failure].
abstract: Large intestine microbiocenosis, levels of endotoxinemia, tumor necrosis factor alpha, C-reactive protein, sE-selectin, matrix metalloproteinase-9 (MMP) and tissue inhibitor of metalloproteinases-4 (TIMP) in chronic heart failure (CHF) patients was studied. Association of dysbiosis and endotoxinemia levels increase, systemic inflammation activation and an imbalance of MMP-TIMP system with progression of CHF has been shown. It can be a reason of a myocardium extracellular matrix structure disturbance and heart remodeling at CHF.
authors.forename: E N
authors.initials: EN
authors.lastname: Egorova
authors.forename: M N
authors.initials: MN
authors.lastname: Kalinkin
authors.forename: E S
authors.initials: ES
authors.lastname: Mazur
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism; D002908:Chronic Disease; D019040:E-Selectin / Q000097:blood; D019446:Endotoxemia / Q000097:blood* / Q000382:microbiology; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000382:microbiology; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000382:microbiology; D007420:Intestine, Large / Q000378:metabolism / Q000382:microbiology; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood; D008875:Middle Aged; D019714:Tissue Inhibitor of Metalloproteinases / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D019040:E-Selectin; D019714:Tissue Inhibitor of Metalloproteinases; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein; D020780:Matrix Metalloproteinase 9