title: 1,3,5,8-tetrahydroxyxanthone regulates ANGPTL3-LPL pathway to lessen the ketosis in mice.
abstract: Ketosis is a metabolic disorder closely associated with both lipid and carbohydrate metabolism. Recent studies show that angiopoietin-like protein 3 (ANGPTL3) contributes to the development of metabolic disorder. The objective of this study was to explore the inhibitory effect of 1,3,5,8-tetrahydroxyxanthone (Xan), a naturally occurring flavonoid compound, on ketosis and the mechanisms involved in this regulation. After 4weeks, Xan (10 or 30mg/kg, intragastrically) treatment decreased plasma total ketone bodies, malondialdehyde, 8-isoprostane, triglyceride, total cholesterol levels, and hepatic ANGPTL3 expression concomitantly with increased plasma glucose concentration and adipose lipoprotein lipase (LPL) expression in ketosis murine. The present results suggest that Xan regulates ANGPTL3-LPL pathway to lessen the ketosis in mice.
authors.affiliation: College of Veterinary Medicine, Hunan Agricultural University, Furong District, Changsha 410128, China. xhbzhb@yahoo.com
authors.forename: Hong-Bo
authors.initials: HB
authors.lastname: Xiao
authors.forename: Zhi-Liang
authors.initials: ZL
authors.lastname: Sun
authors.forename: Nan
authors.initials: N
authors.lastname: Zhou
mesh_terms: D000273:Adipose Tissue / Q000737:chemistry; D000704:Analysis of Variance; D000091303:Angiopoietin-Like Protein 3; D000075802:Angiopoietin-like Proteins; D042682:Angiopoietins / Q000032:analysis / Q000378:metabolism*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood / Q000378:metabolism; D015237:Dinoprost / Q000031:analogs & derivatives / Q000097:blood / Q000378:metabolism; D007657:Ketone Bodies / Q000097:blood / Q000378:metabolism*; D007662:Ketosis / Q000188:drug therapy*; D008071:Lipoprotein Lipase / Q000032:analysis / Q000378:metabolism*; D008099:Liver / Q000737:chemistry; D008297:Male; D008315:Malondialdehyde / Q000097:blood / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D014280:Triglycerides / Q000097:blood / Q000378:metabolism; D044004:Xanthones / Q000494:pharmacology*
chemical_list: C574093:1,3,5,8-tetrahydroxyxanthone; D000091303:Angiopoietin-Like Protein 3; D000075802:Angiopoietin-like Proteins; D042682:Angiopoietins; C404495:Angptl3 protein, mouse; D001786:Blood Glucose; D007657:Ketone Bodies; D014280:Triglycerides; D044004:Xanthones; C075750:8-epi-prostaglandin F2alpha; D008315:Malondialdehyde; D002784:Cholesterol; D015237:Dinoprost; D008071:Lipoprotein Lipase