title: Prescriptions of traditional Chinese medicine are specific to cancer types and adjustable to temperature changes.
abstract: Targeted cancer therapies, with specific molecular targets, ameliorate the side effect issue of radiation and chemotherapy and also point to the development of personalized medicine. Combination of drugs targeting multiple pathways of carcinogenesis is potentially more fruitful. Traditional Chinese medicine (TCM) has been tailoring herbal mixtures for individualized healthcare for two thousand years. A systematic study of the patterns of TCM formulas and herbs prescribed to cancers is valuable. We analysed a total of 187,230 TCM prescriptions to 30 types of cancer in Taiwan in 2007, a year's worth of collection from the National Health Insurance reimbursement database (Taiwan). We found that a TCM cancer prescription consists on average of two formulas and four herbs. We show that the percentage weights of TCM formulas and herbs in a TCM prescription follow Zipf's law with an exponent around 0.6. TCM prescriptions to benign neoplasms have a larger Zipf's exponent than those to malignant cancers. Furthermore, we show that TCM prescriptions, via weighted combination of formulas and herbs, are specific to not only the malignancy of neoplasms but also the sites of origins of malignant cancers. From the effects of formulas and natures of herbs that were heavily prescribed to cancers, that cancers are a 'warm and stagnant' syndrome in TCM can be proposed, suggesting anti-inflammatory regimens for better prevention and treatment of cancers. We show that TCM incorporated relevant formulas to the prescriptions to cancer patients with a secondary morbidity. We compared TCM prescriptions made in different seasons and identified temperatures as the environmental factor that correlates with changes in TCM prescriptions in Taiwan. Lung cancer patients were among the patients whose prescriptions were adjusted when temperatures drop. The findings of our study provide insight to TCM cancer treatment, helping dialogue between modern western medicine and TCM for better cancer care.
authors.affiliation: Institute of Systems Biology and Bioinformatics, National Central University, Chungli Taoyuan, Taiwan.
authors.forename: Pei-Hsun
authors.initials: PH
authors.lastname: Chiu
authors.forename: Hsin-Ying
authors.initials: HY
authors.lastname: Hsieh
authors.forename: Sun-Chong
authors.initials: SC
authors.lastname: Wang
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols; D016208:Databases, Factual; D011307:Drug Prescriptions / Q000706:statistics & numerical data*; D006801:Humans; D008516:Medicine, Chinese Traditional / Q000379:methods*; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy*; D012621:Seasons; D013624:Taiwan; D013696:Temperature