title: Migrating focal seizures during infancy: a case report and pathologic study.
abstract: Migrating focal seizures in infancy are an unusual and often overlooked epilepsy syndrome, with onset before age 6 months, in which nearly continuous seizures involve multiple, independent areas of both hemispheres with an arrest of psychomotor development. We describe a patient with migrating focal seizures in infancy whose seizures began at age 45 days. The seizures were refractory to common antiepileptic drugs. At age 6 months, the infant received potassium bromide and became almost seizure-free. The infant developed severe neurologic impairment, with marked axial hypotonia and an absence of visual contact and head control. At age 8 months, the child suddenly died. Pathologic findings included multiple malformations of cortical development, polymicrogyria, and focal cortical dysplasia associated with hippocampal sclerosis.
authors.affiliation: Department of Neuropediatrics, Prof. Dr. A. Posadas Hospital, Buenos Aires, Argentina. lorena.fasulo@hiba.org.ar
authors.forename: Lorena
authors.initials: L
authors.lastname: Fasulo
authors.forename: Silvia
authors.initials: S
authors.lastname: Saucedo
authors.forename: Lidia
authors.initials: L
authors.lastname: Cáceres
authors.forename: Silvana
authors.initials: S
authors.lastname: Solis
authors.forename: Roberto
authors.initials: R
authors.lastname: Caraballo
mesh_terms: D002540:Cerebral Cortex / Q000002:abnormalities* / Q000473:pathology; D018450:Disease Progression; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007223:Infant; D054220:Malformations of Cortical Development / Q000473:pathology*