title: The connection between GRKs and various signaling pathways involved in diabetic nephropathy.
abstract: Diabetic nephropathy (DN) is a known microvascular complication in patients with diabetes mellitus. DN has become one of the main causes of death in diabetic patients. The occurrence and development of DN results from the comprehensive action of multi-factors, though the exact mechanism is not very clear. Recently, a study found that numerous pathways are activated during the course of the disease, including the PGE2-EP-G protein system, the renin-angiotensin system, protein kinase C, MAPK and oxidative stress, and transforming growth factor-β. G protein-coupled receptor kinases (GRKs), specifically recognize and phosphorylate agonist-activated G protein-coupled receptors, which play a major role in the above-mentioned pathways. The purpose of this paper is to review current information concerning the connection between GRKs and various signaling pathways involved in DN.
authors.affiliation: Institute of Clinical Pharmacology, Anhui Medical University, Hefei, 230032 Anhui, People's Republic of China.
authors.forename: Feng-Ling
authors.initials: FL
authors.lastname: Wang
authors.forename: Li-Qin
authors.initials: LQ
authors.lastname: Tang
authors.forename: Wei
authors.initials: W
authors.lastname: Wei
mesh_terms: D003928:Diabetic Nephropathies / Q000235:genetics / Q000378:metabolism*; D054768:G-Protein-Coupled Receptor Kinases / Q000378:metabolism*; D006801:Humans; D011493:Protein Kinase C / Q000502:physiology; D011982:Receptors, Prostaglandin / Q000502:physiology; D012084:Renin-Angiotensin System / Q000502:physiology; D015398:Signal Transduction; D016212:Transforming Growth Factor beta / Q000502:physiology
chemical_list: D011982:Receptors, Prostaglandin; D016212:Transforming Growth Factor beta; D011493:Protein Kinase C; D054768:G-Protein-Coupled Receptor Kinases