title: Posterior pharyngeal fat grafting for velopharyngeal insufficiency.
abstract: Objective :       To determine if autologous fat grafting to the posterior pharynx can reduce hypernasality in patients with cleft palate and mild velopharyngeal insufficiency (VPI).       Design :       Retrospective case series.       Setting :       Tertiary care center.       Patients :       Eleven patients with cleft palate status after palatoplasty (with or without secondary speech surgery) with nasendoscopic evidence of VPI.       Interventions :       Autologous fat was harvested and injected into the posterior pharynx under general anesthesia.       Main Outcome Measures :       Pre- and postoperative subjective, nasometry, and nasendoscopy data. Apnea-hypopnea indices (AHIs) were also assessed. Comparisons were made using Fisher's exact test, Student's t tests, and relative risk (RR) assessments.       Results :       An average of 13.1 mL of fat was injected (range: 5 to 22 mL). Mean follow-up was 17.5 months (range: 12 to 25 months). Statistically significant improvements in speech resonance were identified in nasometry (Zoo passage; p  =  .027) and subjective hypernasality assessment (p  =  .035). Eight of the patients (73%) demonstrated normal speech resonance after posterior pharyngeal fat grafting (PPFG) on subjective or objective assessment (p  =  .001). All five patients with previous secondary speech surgeries demonstrated normal speech resonance on similar assessment (RR  =  1.8; p  =  .13). Complete velopharyngeal closure was observed in seven patients on postoperative nasendoscopy. No changes in AHIs were observed (p  =  .581).       Conclusion :       PPFG may be best used as an adjunct to secondary speech surgery. In this series, PPFG was not accompanied by the negative sequelae of hyponasality, sleep apnea, or airway compromise.
authors.forename: Darryl
authors.initials: D
authors.lastname: Lau
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Oppenheimer
authors.forename: Steve R
authors.initials: SR
authors.lastname: Buchman
authors.forename: Mary
authors.initials: M
authors.lastname: Berger
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Kasten
mesh_terms: D002972:Cleft Palate / Q000601:surgery; D006801:Humans; D010614:Pharynx / Q000601:surgery; D012189:Retrospective Studies; D016896:Treatment Outcome; D014681:Velopharyngeal Insufficiency / Q000601:surgery