title: Osteoblastic functions: a lesson from biochemical bone markers.
abstract: The present study showed the lowest values of bone markers from osteoblast, NMID osteocalcin, 10.81 +/- 3.9 ng/ ml and PINP 15.88 +/- 7.09 ng/ml at lowest level of osteoclast, betaCTx, 0.066 + 0.22 ng/ml should be the cut value for osteoblastic function. At this level betaCTx, had no correlation with PINP (r = 0.198, p = 0.003) or NMID osteocalcin (r = 0.035, p = 0.606) compared to the normal value of the control group and the correlation (r) between betaCTx and NMID osteocalcin, betaCTx and PINP, which were 0.757 and 0.752 (p = 0.001) respectively and recognized as normal bone turnover with coupling effect. So, bone markers of osteoblast at the lowest value of betaCTx (0.066 ng/ml) with NMID osteocalcin, 10.81 +/- 3.9 ng/ml and PINP 15.887.09 ng/ml may be the cut value of osteoblast reflecting poor functions. The benefit of identifying the cut values of osteoblast will help in making decisions in osteoporotic management.
authors.affiliation: Department of Orthopaedic Surgery, Siriraj Hospital, Mahidol University, Bangkok, Thailand. todrnarong@yahoo.com
authors.forename: Narong
authors.initials: N
authors.lastname: Bunyaratavej
mesh_terms: D015415:Biomarkers / Q000032:analysis*; D016723:Bone Remodeling / Q000502:physiology*; D003094:Collagen / Q000097:blood*; D005260:Female; D006801:Humans; D010006:Osteoblasts / Q000502:physiology*; D015675:Osteocalcin / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; C110762:glutamyl-lysyl-alanyl-histidyl-aspartyl-glycyl-glycyl-arginine; D015675:Osteocalcin; D003094:Collagen