title: Successful treatment of sepsis caused by Staphylococcus lugdunensis in an adult with 22q11.2 deletion syndrome.
abstract: A 27-year-old woman visited our hospital because of high fever. She had been diagnosed as 22q11.2 deletion syndrome (22q11.2DS) due to her cardiac history (tetralogy of Fallot), thymic hypoplasia and 22q11.2 deletion. She had a normal CD4/CD8 ratio, a slightly decreased lymphocyte count and normal serum immunoglobulin levels. Blood cultures were positive for Staphylococcus lugdunensis (S. lugdunensis). Infection route of S. lugdunensis in this case was unclear. The patient was successfully treated with several intravenous antibiotics. Infection should be considered when managing patients with 22q.11.2DS. regardless of whether their immune system is impaired.
authors.affiliation: Department of General Medicine, Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Japan. s.hirasaki@kousei-hp.or.jp
authors.forename: Shoji
authors.initials: S
authors.lastname: Hirasaki
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Murakami
authors.forename: Takaaki
authors.initials: T
authors.lastname: Mizushima
authors.forename: Kazuyoshi
authors.initials: K
authors.lastname: Ohmori
authors.forename: Seiko
authors.initials: S
authors.lastname: Fujita
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Hanayama
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Kanamori
authors.forename: Ryo
authors.initials: R
authors.lastname: Yokota
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Ebara
authors.forename: Nobuchika
authors.initials: N
authors.lastname: Kusano
authors.forename: Chieko
authors.initials: C
authors.lastname: Kudo
authors.forename: Tomoko
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: Teiji
authors.initials: T
authors.lastname: Akagi
authors.forename: Norio
authors.initials: N
authors.lastname: Koide
mesh_terms: D058165:22q11 Deletion Syndrome / Q000150:complications*; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D018805:Sepsis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D013203:Staphylococcal Infections / Q000175:diagnosis / Q000188:drug therapy*; D057787:Staphylococcus lugdunensis
chemical_list: D000900:Anti-Bacterial Agents