title: Attenuation of resting energy expenditure following hematopoietic SCT in children.
abstract: Children undergoing hematopoietic SCT (HSCT) typically receive parenteral nutrition (PN) due to gastrointestinal toxicities. Accurate determination of resting energy expenditure (REE) may facilitate optimal energy provision and help avoid unintended overfeeding or underfeeding. A multicenter, prospective cohort study of children undergoing allogeneic HSCT was performed, in which REE was measured by indirect calorimetry at baseline and twice weekly until 30 days after transplantation. Change in percent predicted REE over time from admission was analyzed using repeated measures regression analysis. In all, 26 children (14 females) with a mean (s.d.) age of 14.9 (4.2) years who underwent an HLA-matched sibling or unrelated donor transplantation were enrolled. Mean (s.d.) percent predicted REE at baseline was 92.4 (15.2). Baseline REE was highly correlated with lean body mass measured by dual energy X-ray absorptiometry (r=0.78, P<0.0001). REE decreased significantly over time, following a quadratic curve to a nadir of 79% predicted at 14 days post transplantation (P<0.001) and returned to near baseline by day 30. Children undergoing HSCT exhibit a significant reduction in REE in the early weeks after transplantation, a phenomenon that places them at risk for overfeeding. Serial measurements of REE or reductions in energy intake should be considered when PN is the primary mode of nutrition.
authors.affiliation: Clinical Nutrition Service, Children's Hospital Boston, 300 Longwood Avenue, Boston, MA 02115, USA. lori.bechard@childrens.harvard.edu
authors.forename: L J
authors.initials: LJ
authors.lastname: Bechard
authors.forename: H A
authors.initials: HA
authors.lastname: Feldman
authors.forename: R
authors.initials: R
authors.lastname: Venick
authors.forename: K
authors.initials: K
authors.lastname: Gura
authors.forename: C
authors.initials: C
authors.lastname: Gordon
authors.forename: A
authors.initials: A
authors.lastname: Sonis
authors.forename: N
authors.initials: N
authors.lastname: Mehta
authors.forename: E C
authors.initials: EC
authors.lastname: Guinan
authors.forename: C
authors.initials: C
authors.lastname: Duggan
mesh_terms: D000293:Adolescent; D000328:Adult; D015992:Body Mass Index; D002648:Child; D004311:Double-Blind Method; D002149:Energy Intake; D004734:Energy Metabolism; D005260:Female; D019337:Hematologic Neoplasms / Q000503:physiopathology / Q000628:therapy; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D010288:Parenteral Nutrition; D011446:Prospective Studies; D012146:Rest; D035781:Siblings; D013997:Time Factors; D014184:Transplantation, Homologous; D061349:Unrelated Donors