title: [Long-term outcome analysis of patients underwent percutaneous coronary intervention with prior ischemic stroke].
abstract: OBJECTIVE
  To analyze the clinical characteristics and long-term outcomes of patients underwent percutaneous coronary intervention (PCI) with prior ischemic stroke.
  
  
  METHODS
  A total of 2053 patients underwent PCI in Peking union medical college hospital from January 2003 to December 2007 were included in this analysis and patients were followed up to December 2009. End-point included all-cause mortality, cardiac death, stent thrombosis, target-lesion revascularization, myocardial infarction, re-cerebral infarction. Major bleeding events were recorded during follow-up.
  
  
  RESULTS
  There are 1945 coronary heart disease patients were followed up and 222 patients with prior ischemic stroke. Compared patients without prior ischemic stroke, patients with prior ischemic stroke were older (P = 0.000), had higher hypertension morbidity (P = 0.000), higher diabetes mellitus morbidity (P = 0.005), higher incidence of multi-vessels disease (P = 0.000). During the follow-up of (35.0 ± 19.6) months, cardiac death rate (8.5% vs. 3.9%, P = 0.002) and re-cerebral infarction rate (5.8% vs. 1.4%, P = 0.000) were higher in patients with prior ischemic stroke than patients without prior ischemic stroke. Dual antiplatelet therapy treatment time [(13.77 ± 11.33) months vs. (13.94 ± 11.33) months, P = 0.986] and major bleeding events (5.8% vs. 3.6%, P = 0.100) were similar between the two groups and cerebral hemorrhage rate (1.8% vs. 0.5%, P = 0.028) were higher in patients with prior ischemic stroke than patients without prior ischemic stroke.
  
  
  CONCLUSIONS
  Patients with prior ischemic stroke were associated with increased rate of risk factors, multiple coronary artery disease, cardiac death and re-cerebral infarction and higher cerebral hemorrhage rate during follow-up despite similar dual-anti platelet therapy time.
authors.affiliation: Department of Cardiology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.
authors.forename: Ye-chen
authors.initials: YC
authors.lastname: Han
authors.forename: Shu-yang
authors.initials: SY
authors.lastname: Zhang
authors.forename: Song-bai
authors.initials: SB
authors.lastname: Lin
authors.forename: Zhu-jun
authors.initials: ZJ
authors.lastname: Shen
authors.forename: Zhong-jie
authors.initials: ZJ
authors.lastname: Fan
authors.forename: Chong-hui
authors.initials: CH
authors.lastname: Wang
authors.forename: Xiao-feng
authors.initials: XF
authors.lastname: Jin
authors.forename: Hong-zhi
authors.initials: HZ
authors.lastname: Xie
authors.forename: Zhen-yu
authors.initials: ZY
authors.lastname: Liu
authors.forename: Yong
authors.initials: Y
authors.lastname: Zeng
authors.forename: Quan
authors.initials: Q
authors.lastname: Fang
mesh_terms: D000368:Aged; D002545:Brain Ischemia; D003327:Coronary Disease / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention; D012189:Retrospective Studies; D012307:Risk Factors; D020521:Stroke; D016896:Treatment Outcome