title: Postorthodontic external root resorption in root-filled teeth is influenced by interleukin-1β polymorphism.
abstract: BACKGROUND
  External apical root resorption (EARR) is a frequent iatrogenic effect of orthodontic treatment. The way root-filled teeth respond to orthodontic forces with respect to EARR has been reported as varying widely between individuals. Genetic variants in the interleukin-1 gene have been associated with an increased risk of experiencing postorthodontic EARR on vital teeth. The objective of this study is to determine whether variants in the interleukin-1 gene have a positive or negative influence on EARR on teeth that have been endodontically treated.
  
  
  METHODS
  Ninety-three orthodontic patients underwent genetic screening for 2 single nucleotide polymorphisms (rs1800587, rs1143634) in the IL1 gene cluster. Subjects were divided into 2 groups depending on the presence (affected group) or absence (control group) of more than 2 mm of EARR on root-filled teeth after orthodontic treatment as shown by radiography. Logistic regression analysis was used to obtain adjusted estimates of EARR and IL1 polymorphisms. Allele frequencies, genotype distributions, and adjusted odds ratios were also calculated (95% confidence interval).
  
  
  RESULTS
  No positive or negative statistical association was found between postorthodontic treatment EARR in root-filled teeth and genetic variations in IL1A (P > .05). A direct relationship was found for the IL1B gene in the comparative analysis of homozygous subjects (2/2[TT]) and (1/1[CC]), which led to an increased risk of experiencing postorthodontic treatment EARR in root-filled teeth (odds ratio = 11.59; P = .006; confidence interval, 95%) and (odds ratio = 2.54; P = .035; confidence interval, 95%), respectively.
  
  
  CONCLUSIONS
  The development of EARR in subjects with root-filled teeth who undergo orthodontic treatment might be attributable to genetic variations in the interleukin-1β gene (rs1143634).
authors.affiliation: Department of Orthodontics, School of Dentistry, University of Seville, Seville, Spain. brpi@us.es
authors.forename: Alejandro
authors.initials: A
authors.lastname: Iglesias-Linares
authors.forename: Rosa-María
authors.initials: RM
authors.lastname: Yañez-Vico
authors.forename: Estefanía
authors.initials: E
authors.lastname: Ortiz-Ariza
authors.forename: Sofía
authors.initials: S
authors.lastname: Ballesta
authors.forename: Asunción
authors.initials: A
authors.lastname: Mendoza-Mendoza
authors.forename: Evelio
authors.initials: E
authors.lastname: Perea
authors.forename: Enrique
authors.initials: E
authors.lastname: Solano-Reina
mesh_terms: D001641:Bicuspid / Q000473:pathology; D002508:Cephalometry; D003596:Cytosine; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D014644:Genetic Variation / Q000235:genetics; D005838:Genotype; D006720:Homozygote; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics*; D008297:Male; D005810:Multigene Family / Q000235:genetics; D009811:Odontometry; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D019252:Radiography, Dental, Digital; D011862:Radiography, Panoramic; D012391:Root Resorption / Q000000981:diagnostic imaging / Q000209:etiology*; D013941:Thymine; D014087:Tooth Movement Techniques / Q000009:adverse effects*; D019553:Tooth, Nonvital / Q000000981:diagnostic imaging / Q000473:pathology*; D055815:Young Adult
chemical_list: D053583:Interleukin-1beta; D003596:Cytosine; D013941:Thymine