title: Solute Carrier Family 19, member 1 (SLC19A1) polymorphisms (-43T>C, 80G>A, and 696C>T), and haplotypes in idiopathic recurrent spontaneous abortion in a Korean population.
abstract: The objective was to investigate the association between idiopathic recurrent spontaneous abortion (RSA) and 3 SLC19A1 polymorphisms (-43T>C, 80G>A, and 696C>T). DNA from 269 patients with RSA and 125 controls were genotyped for the 3 SLC19A1 single nucleotide polymorphisms (SNPs) by polymerase chain reaction-restriction fragment length polymorphism. Homocysteine and folate levels of 100 patients with RSA were available for analysis. The combination genotypes of SLC19A1 -43TC/80GG, -43TC/80AA, and -43CC/80GA; 80GA/696TT, 80AA/696CC; and -43TC/696CC were less frequent in patients with RSA compared to controls (P < .05 for each). The -43C/80A/696 T and -43T/80G/696C haplotypes were more frequent in patients than controls, whereas -43T/80A/696C, -43C/80A/696C, -43C/80G/696C, -43C/80G/696T, and -43T/80G/696T haplotypes were less frequent in patients (P < .05 for each). The -43T/80G and 80A/696T haplotypes were more frequent in patients, while -43T/80A, -43C/80G, 80A/696C, 80G/696T, and -43C/696C haplotypes occurred less frequently in patients (P < .05 for each). The associations between idiopathic RSA occurrence and SLC19A1 -43T>C/80G>A/696C>T polymorphisms were identified and can be developed as biomarkers for RSA risk.
authors.affiliation: Department of Biomedical Science, College of Life Science, CHA University, Seongnam, South Korea.
authors.forename: HyungChul
authors.initials: H
authors.lastname: Rah
authors.forename: Yi Seul
authors.initials: YS
authors.lastname: Choi
authors.forename: Young Joo
authors.initials: YJ
authors.lastname: Jeon
authors.forename: Youngsok
authors.initials: Y
authors.lastname: Choi
authors.forename: Sun Hee
authors.initials: SH
authors.lastname: Cha
authors.forename: Dong Hee
authors.initials: DH
authors.lastname: Choi
authors.forename: Jung Jae
authors.initials: JJ
authors.lastname: Ko
authors.forename: Sung Han
authors.initials: SH
authors.lastname: Shim
authors.forename: Nam Keun
authors.initials: NK
authors.lastname: Kim
mesh_terms: D000026:Abortion, Habitual / Q000097:blood / Q000235:genetics*; D000328:Adult; D005260:Female; D005492:Folic Acid / Q000097:blood; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes / Q000235:genetics*; D006710:Homocysteine / Q000097:blood; D006801:Humans; D007723:Korea; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011247:Pregnancy; D058978:Reduced Folate Carrier Protein / Q000235:genetics*; D012307:Risk Factors
chemical_list: D058978:Reduced Folate Carrier Protein; C548699:SLC19A1 protein, human; D006710:Homocysteine; D005492:Folic Acid