title: In-transit melanoma: an individualized approach.
abstract: The majority of locoregional recurrences in melanoma occur in the form of intradermal or subcutaneous local or in-transit metastasis. In-transit melanoma represents contamination of the lymphatic space that, if treated, can result in long-term cure in a subset of patients. The management of in-transit metastases is challenging, since the treatments and extent of disease vary greatly based on the number, depth, location, and distribution of lesions, and on their biological behavior. A number of different treatment options exist, but there is no level 1 evidence to guide clinical decision-making. Herein we present our institutional treatment algorithm, which allows for individualization based on the patient's presentation.
authors.affiliation: Department of Surgery, Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: Travis E
authors.initials: TE
authors.lastname: Grotz
authors.forename: Aaron S
authors.initials: AS
authors.lastname: Mansfield
authors.forename: Lisa A
authors.initials: LA
authors.lastname: Kottschade
authors.forename: Lori A
authors.initials: LA
authors.lastname: Erickson
authors.forename: Clark C
authors.initials: CC
authors.lastname: Otley
authors.forename: Svetomir N
authors.initials: SN
authors.lastname: Markovic
authors.forename: James W
authors.initials: JW
authors.lastname: Jakub
mesh_terms: D000465:Algorithms; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D010478:Chemotherapy, Cancer, Regional Perfusion; D053672:Electrochemotherapy; D006801:Humans; D015552:Injections, Intralesional; D054025:Lasers, Dye / Q000627:therapeutic use; D008207:Lymphatic Metastasis; D008545:Melanoma / Q000556:secondary* / Q000628:therapy*; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D009367:Neoplasm Staging; D012878:Skin Neoplasms / Q000473:pathology* / Q000628:therapy*
chemical_list: D000970:Antineoplastic Agents