title: Impact of carotid artery stenting on plasma interleukin-6, tumor necrosis factor-α and C-reactive protein.
abstract: OBJECTIVE
  This study aimed to investigate the impact of carotid artery stenting (CAS) on plasma levels of interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α) and C-reactive protein (CRP).
  
  
  METHODS
  The levels of CRP, IL-6, and TNF-α were measured in 61 patients before CAS, 1 h, 2 weeks, 1 month, 6 months, and 12 months after the stenting.
  
  
  RESULTS
  The levels of CRP, IL-6 and TNF-α increased immediately after CAS (P<0.05 or <0.01). The levels of CRP, IL-6 and TNF-α in patients receiving two stents for multiple lesions or single diffusive lesions was also high than in patients receiving one stent for a single lesion (P<0.05 or <0.01). The levels of CRP, IL-6 and TNF-α in patients with restenosis (14/61, or 23%) were higher than in those without restenosis (P<0.05 or <0.01).
  
  
  CONCLUSIONS
  CAS was associated with a significant increase in plasma CRP, IL-6 and TNF-α. The levels of these inflammatory factors in patients with post-CAS restenosis were higher than in those without restenosis.
authors.affiliation: Department of Neurology, Liaocheng People's Hospital and Liaocheng Clinical School of Taishan Medical University Liaocheng, Shandong Province, PR China.
authors.forename: Z Y
authors.initials: ZY
authors.lastname: Xia
authors.forename: H
authors.initials: H
authors.lastname: Yang
authors.forename: H Q
authors.initials: HQ
authors.lastname: Qu
authors.forename: W D
authors.initials: WD
authors.lastname: Cheng
authors.forename: L X
authors.initials: LX
authors.lastname: Wang
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D015901:Angiography, Digital Subtraction; D017130:Angioplasty / Q000295:instrumentation*; D002097:C-Reactive Protein / Q000378:metabolism*; D016893:Carotid Stenosis / Q000097:blood / Q000000981:diagnostic imaging / Q000276:immunology / Q000628:therapy*; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D015607:Stents; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*; D015854:Up-Regulation
chemical_list: C508600:IL6 protein, human; D018836:Inflammation Mediators; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein