title: Asymmetric synthesis of 4,8-dihydroxyisochroman-1-one polyketide metabolites using chiral hypervalent iodine(III).
abstract: Stereoselective oxylactonization of ortho-alkenylbenzoate with chiral hypervalent iodine is applied to the asymmetric synthesis of 4-oxyisochroman-1-one polyketide metabolites including 4-hydroxymellein (1), a derivative of fusarentin 2, monocerin (3), and an epimer of monocerin epi-3.
authors.affiliation: Graduate School of Material Science, University of Hyogo, Kohto, Kamigori, Hyogo 678-1297, Japan. fuji@sci.u-hyogo.ac.jp
authors.forename: Morifumi
authors.initials: M
authors.lastname: Fujita
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Mori
authors.forename: Mio
authors.initials: M
authors.lastname: Shimogaki
authors.forename: Takashi
authors.initials: T
authors.lastname: Sugimura
mesh_terms: D001688:Biological Products / Q000737:chemistry / Q000378:metabolism; D002384:Catalysis; D002839:Chromans / Q000737:chemistry*; D007455:Iodine / Q000737:chemistry*; D015394:Molecular Structure; D061065:Polyketides / Q000138:chemical synthesis* / Q000378:metabolism; D013237:Stereoisomerism
chemical_list: C572281:4,8-dihydroxyisochroman-1-one; D001688:Biological Products; D002839:Chromans; D061065:Polyketides; D007455:Iodine