title: EEG-fMRI validation studies in comparison with icEEG: a review.
abstract: Simultaneous EEG-fMRI is a non-invasive investigation technique developed to localize the generators of interictal epileptiform discharges (IED) in patients with epilepsy. Although the value of EEG-fMRI in epilepsy presurgical evaluation is being assessed clinically, its utility is still controversial. In this review, we considered EEG-fMRI applications in epilepsy presurgical evaluation with a focus on validation studies that compared the results of EEG-fMRI with those of the current "gold standard" intracranial EEG (icEEG) in order to assess its utility of seizure focus localization and the possibility for EEG-fMRI to reduce the need for invasive techniques such as icEEG. Since the advances of EEG-fMRI partially rely on the maturation of its data analysis, we also reviewed the methodological developments in EEG-fMRI analysis. It is possible that combining with other neuroimaging modalities such as MEG/MSI and ESI, EEG-fMRI may play a greater role in epilepsy presurgical evaluation.
authors.affiliation: School of Biomedical Engineering, Capital Medical University, Beijing 100069, PR China.
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Weifang
authors.initials: W
authors.lastname: Liu
authors.forename: Hui
authors.initials: H
authors.lastname: Chen
authors.forename: Hong
authors.initials: H
authors.lastname: Xia
authors.forename: Zhen
authors.initials: Z
authors.lastname: Zhou
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Shanshan
authors.initials: S
authors.lastname: Mei
authors.forename: Qingzhu
authors.initials: Q
authors.lastname: Liu
authors.forename: Yunlin
authors.initials: Y
authors.lastname: Li
mesh_terms: D000818:Animals; D001927:Brain Diseases / Q000175:diagnosis* / Q000503:physiopathology*; D004569:Electroencephalography / Q000592:standards*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000592:standards*