title: Electrocardiogram-assisted blood pressure estimation.
abstract: Accurate automatic noninvasive assessment of blood pressure (BP) presents a challenge due to conditions like arrhythmias, obesity, and postural changes that tend to obfuscate arterial amplitude pulsations sensed by the cuff. Researchers tried to overcome this challenge by analyzing oscillometric pulses with the aid of a higher fidelity signal-the electrocardiogram (ECG). Moreover, pulse transit time (PTT) was employed to provide an additional method for BP estimation. However, these methods were not fully developed, suitably integrated, or tested. To address these issues, we present a novel method whereby ECG-assisted oscillometric and PTT (measured between ECG R-peaks and maximum slope of arterial pulse peaks) analyses are seamlessly integrated into the oscillometric BP measurement paradigm. The method bolsters oscillometric analysis (amplitude modulation) with more reliable ECG R-peaks provides a complementary measure with PTT analysis (temporal modulation) and fuses this information for robust BP estimation. We have integrated this technology into a prototype that comprises a BP cuff with an embedded conductive fabric ECG electrode, associated hardware, and algorithms. A pilot study has been undertaken on ten healthy subjects (150 recordings) to validate the performance of our prototype against United States Food and Drug Administration approved Omron oscillometric monitor (HEM-790IT). Our prototype achieves mean absolute difference of less than 5 mmHg and grade A as per the British Hypertension Society protocol for estimating BP, with the reference Omron monitor.
authors.affiliation: School of Electrical Engineering and Computer Science, University of Ottawa, Ottawa, ON, Canada. sahmad@site.uottawa.ca
authors.forename: Saif
authors.initials: S
authors.lastname: Ahmad
authors.forename: Silu
authors.initials: S
authors.lastname: Chen
authors.forename: Karen
authors.initials: K
authors.lastname: Soueidan
authors.forename: Izmail
authors.initials: I
authors.lastname: Batkin
authors.forename: Miodrag
authors.initials: M
authors.lastname: Bolic
authors.forename: Hilmi
authors.initials: H
authors.lastname: Dajani
authors.forename: Voicu
authors.initials: V
authors.lastname: Groza
mesh_terms: D000328:Adult; D000465:Algorithms; D001795:Blood Pressure Determination / Q000295:instrumentation*; D002138:Calibration; D004562:Electrocardiography / Q000379:methods*; D004566:Electrodes; D004867:Equipment Design; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009991:Oscillometry / Q000295:instrumentation; D010865:Pilot Projects; D011674:Pulse; D012984:Software; D019722:Sphygmomanometers / Q000592:standards*; D013784:Textiles