title: Predicting skin permeability from complex vehicles.
abstract: It is now widely accepted that vehicle and formulation components influence the rate and extent of passive chemical absorption through skin. Significant progress, over the last decades, has been made in predicting dermal absorption from a single vehicle; however the effect of a complex, realistic mixture has not received its due attention. Recent studies have aimed to bridge this gap by extending the use of quantitative structure-permeation relationship (QSPR) models based on linear free energy relationships (LFER) to predict dermal absorption from complex mixtures with the inclusion of significant molecular descriptors such as a mixture factor that accounts for the physicochemical properties of the vehicle/mixture components. These models have been compiled and statistically validated using the data generated from in vitro or ex vivo experimental techniques. This review highlights the progress made in predicting skin permeability from complex vehicles.
authors.affiliation: Center for Chemical Toxicology Research and Pharmacokinetics, North Carolina State University, Raleigh, NC 27607, USA.
authors.forename: Daniela
authors.initials: D
authors.lastname: Karadzovska
authors.forename: James D
authors.initials: JD
authors.lastname: Brooks
authors.forename: Nancy A
authors.initials: NA
authors.lastname: Monteiro-Riviere
authors.forename: Jim E
authors.initials: JE
authors.lastname: Riviere
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems; D006801:Humans; D018499:Linear Energy Transfer; D008962:Models, Theoretical; D010539:Permeability; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000378:metabolism; D014677:Pharmaceutical Vehicles / Q000737:chemistry; D021281:Quantitative Structure-Activity Relationship; D012867:Skin / Q000378:metabolism; D012869:Skin Absorption
chemical_list: D004364:Pharmaceutical Preparations; D014677:Pharmaceutical Vehicles