title: B-lymphocyte reconstitution after repeated rituximab treatment in a child with steroid-dependent autoimmune hemolytic anemia.
abstract: We report the detailed long-term reconstitution of B-lymphocyte subpopulations, immunoglobulins, and specific antibody production after two courses of rituximab in a young, previously healthy girl with steroid-dependent autoimmune hemolytic anemia. B-lymphocyte subpopulations were surprisingly normal directly after reconstitution. However, there was a slower reconstitution after the second rituximab course, especially of non-switched and switched memory B-lymphocytes, and a temporary decline in IgM below age-matched reference values.
authors.affiliation: Department of Pediatrics;
authors.forename: Annelieke A A
authors.initials: AA
authors.lastname: van der Linde
authors.forename: Ellen J H
authors.initials: EJ
authors.lastname: Schatorjé
authors.forename: Annemieke M
authors.initials: AM
authors.lastname: van der Weij
authors.forename: Eugenie F A
authors.initials: EF
authors.lastname: Gemen
authors.forename: Esther
authors.initials: E
authors.lastname: de Vries