title: RORγt-dependent IL-17A-producing cells in the pathogenesis of intestinal inflammation.
abstract: The hypothesis of helper T (T(h))1/T(h)2 cytokine balance proposed by Mosmann and Coffman is often invoked to explain the development of inflammatory diseases, including inflammatory bowel diseases (IBD). Recently, however, a newly identified class of T(h) cells-T(h)17 cells, which produce T(h)17 family cytokines-has been recognized as an essential subpopulation in the development of almost all kinds of human and animal inflammatory diseases, rather than T(h)1 and T(h)2 cells. A representative T(h)17 family cytokine, interleukin (IL)-17A, is produced by not only T(h)17 cells, but also by other types of cells, such as T-cell receptor γδ T cells, natural killer (NK) T cells, NK cells, myeloid cells, and innate lymphoid cells, which may also be critically involved in the initiation and persistence of IBD. Here we review recent advances in the study of such IL-17A-producing cells in the pathogenesis of IBD.
authors.affiliation: Division of Gastroenterology and Hepatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kanai
authors.forename: Y
authors.initials: Y
authors.lastname: Mikami
authors.forename: T
authors.initials: T
authors.lastname: Sujino
authors.forename: T
authors.initials: T
authors.lastname: Hisamatsu
authors.forename: T
authors.initials: T
authors.lastname: Hibi
mesh_terms: D000818:Animals; D006801:Humans; D018928:Immunity, Mucosal; D018836:Inflammation Mediators / Q000276:immunology; D015212:Inflammatory Bowel Diseases / Q000276:immunology*; D020381:Interleukin-17 / Q000276:immunology*; D007422:Intestines / Q000276:immunology; D022423:Myeloid Cells / Q000276:immunology; D055611:Natural Killer T-Cells / Q000276:immunology; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3 / Q000276:immunology*; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D058408:Th1-Th2 Balance; D058504:Th17 Cells / Q000276:immunology*
chemical_list: D018836:Inflammation Mediators; D020381:Interleukin-17; D057132:Nuclear Receptor Subfamily 1, Group F, Member 3; D016692:Receptors, Antigen, T-Cell, gamma-delta