title: [The incidence of malignancies and surveillance of hematopoietic stem cells donors--the results of the Haemato-Oncology Department University Hospital in Plzen (Pilsen) and Czech National Marrow Donors Registry observation].
abstract: BACKGROUND
  Granulopoesis colony-stimulating factor filgrastim is used to mobilize peripheral stem cells but there are concerns regarding an elevated risk of haematological malignancies. We analyzed the incidence of malignancies and the system of haematopoietic stem cells donor surveillance.
  
  
  METHODS
  prospective observation of sibling donors of the Haemato-Oncology Department University Hospital in Plzen (Pilsen) and of unrelated donors of the Czech National Marrow Donors Registry (CNMDR) in 2001-2010.
  
  
  RESULTS
  No malignancy was observed in a group of 344 unrelated CNMDR donors, providing 753 person-years; one case of chronic lymphocytic leukaemia manifested 6 years after bone marrow donation, with leukaemia clone retrospectively detected by DNA analysis in blood samples taken prior to the marrow donation. Acute myeloid leukaemia, non-Hodgkin lymphoma, renal and colorectal carcinoma were observed in a group of 84 peripheral stem cells sibling donors, providing 337 person-years observation. The respective incidence of the two haematologic malignancies was 593 cases and the expected incidence rate was 143 per 100,000. The sibling (related) donors age was significantly higher: 48 (16-75) vs. 31 (20-42) years, (p<0.0001). Significantly more lost-to-follow-up donors were among the related donors (32% vs. 3%, p<0.0001), even though active surveillance system was implemented.
  
  
  CONCLUSIONS
  The development of malignancies in hematopoietic stem cells donors can naturally be expected. Related (sibling) donors are at higher risk because of their generally older age, and higher susceptibility to haematological malignancies developed within the family. The contribution of filgrastim exposure needs to be further investigated. The follow-up cooperation with related (sibling) donors is limited.
authors.affiliation: Hematologicko-onkologické oddelení, FN Plzen. vokurka@fnplzen.cz
authors.forename: S
authors.initials: S
authors.lastname: Vokurka
authors.forename: V
authors.initials: V
authors.lastname: Koza
authors.forename: A
authors.initials: A
authors.lastname: Jungová
authors.forename: J
authors.initials: J
authors.lastname: Navrátilová
authors.forename: T
authors.initials: T
authors.lastname: Svoboda
authors.forename: P
authors.initials: P
authors.lastname: Jindra
authors.forename: K
authors.initials: K
authors.lastname: Steinerová
authors.forename: M
authors.initials: M
authors.lastname: Hrabětová
authors.forename: R
authors.initials: R
authors.lastname: Výrutová
authors.forename: L
authors.initials: L
authors.lastname: Novák
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D000069585:Filgrastim; D016179:Granulocyte Colony-Stimulating Factor / Q000009:adverse effects*; D019337:Hematologic Neoplasms / Q000209:etiology*; D019650:Hematopoietic Stem Cell Mobilization / Q000009:adverse effects*; D006412:Hematopoietic Stem Cells; D006801:Humans; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000009:adverse effects; D035781:Siblings; D055815:Young Adult
chemical_list: D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D000069585:Filgrastim