title: Ruthenium-based complex nanocarriers for cancer therapy.
abstract: A new organometallic ruthenium complex, named AziRu, along with three amphiphilic nucleoside-based ruthenium complexes, ToThyRu, HoThyRu and DoHuRu, incorporating AziRu in their skeleton, have been synthesized, stabilized in POPC phospholipid formulations and studied for their antineoplastic activity. Self-aggregation behavior of these complexes was investigated, showing that the three synthesized AziRu derivatives able to form liposomes and, under specific conditions, elongated micelles. The formulations prepared in POPC proved to be stable for months and showed high in vitro antiproliferative activity. The here described results open new scenarios in the design of innovative transition metal-based supramolecular systems for anticancer drugs vectorization.
authors.affiliation: Dipartimento di Scienze Chimiche, Università degli Studi di Napoli Federico II, Complesso Universitario di Monte S. Angelo, via Cintia, 80126 Naples, Italy.
authors.forename: Gaetano
authors.initials: G
authors.lastname: Mangiapia
authors.forename: Gerardino
authors.initials: G
authors.lastname: D'Errico
authors.forename: Luca
authors.initials: L
authors.lastname: Simeone
authors.forename: Carlo
authors.initials: C
authors.lastname: Irace
authors.forename: Aurel
authors.initials: A
authors.lastname: Radulescu
authors.forename: Antonio
authors.initials: A
authors.lastname: Di Pascale
authors.forename: Alfredo
authors.initials: A
authors.lastname: Colonna
authors.forename: Daniela
authors.initials: D
authors.lastname: Montesarchio
authors.forename: Luigi
authors.initials: L
authors.lastname: Paduano
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000737:chemistry; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004337:Drug Carriers; D004355:Drug Stability; D006801:Humans; D008081:Liposomes; D008422:Materials Testing; D008856:Microscopy, Fluorescence; D053758:Nanoparticles / Q000008:administration & dosage* / Q000737:chemistry; D009369:Neoplasms / Q000188:drug therapy*; D009942:Organometallic Compounds / Q000008:administration & dosage* / Q000737:chemistry; D051381:Rats; D012428:Ruthenium / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D008081:Liposomes; D009942:Organometallic Compounds; D012428:Ruthenium