title: Polymorphism of the angiotensin-converting enzyme gene and angiotensin-converting enzyme activity in transient tachypnea of neonate and respiratory distress syndrome.
abstract: BACKGROUND
  Transient tachypnea of neonate (TTN) and respiratory distress syndrome (RDS) of the newborn are the most common cause of early respiratory distress in the immediate neonatal period. There is increasing evidence to support the role for the activation of the renin angiotensin system during acute lung injury.
  
  
  OBJECTIVE
  The purpose of this study was to determine if there is a relationship between angiotensin-converting enzyme (ACE) I/D polymorphism, ACE activity and TTN and respiratory distress syndromes.
  
  
  METHODS
  Nineteen neonates with TTN, 20 neonates with RDS and 21 control infants are studied for ACE polymorphism and serum ACE activity.
  
  
  RESULTS
  Twenty six (43.3%) patients have DD polymorphism, 19 (31.7%) patients have ID polymorphism and 15 (25%) patients have II polymorphism. Serum ACE activity is 43.5 ± 1.8 (40-46) U/L in DD, 31.5 ± 2.3 (28-36) U/L in ID and 22.1 ± 2.1(19-46) U/L in II patient.
  
  
  CONCLUSIONS
  The study could not find any difference in DD alleles and ACE activity between control group and TTN group. ACE polymorphism was not different between RDS group and control group in this study.
authors.affiliation: Department of Neonatology, Çukurova University, Adana, Turkey.
authors.forename: Mehmet
authors.initials: M
authors.lastname: Satar
authors.forename: Erdal
authors.initials: E
authors.lastname: Taşkın
authors.forename: Ferda
authors.initials: F
authors.lastname: Özlü
authors.forename: Abdullah
authors.initials: A
authors.lastname: Tuli
authors.forename: Kenan
authors.initials: K
authors.lastname: Özcan
authors.forename: Hacer Y
authors.initials: HY
authors.lastname: Yıldızdaş
mesh_terms: D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005865:Gestational Age; D006801:Humans; D054643:INDEL Mutation / Q000502:physiology; D007231:Infant, Newborn; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000235:genetics* / Q000378:metabolism*; D011110:Polymorphism, Genetic / Q000502:physiology; D012127:Respiratory Distress Syndrome, Newborn / Q000150:complications / Q000235:genetics* / Q000378:metabolism; D059245:Transient Tachypnea of the Newborn / Q000150:complications / Q000235:genetics* / Q000378:metabolism
chemical_list: C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A