title: Abnormal spinal cord pain processing in Huntington's disease. The role of the diffuse noxious inhibitory control.
abstract: OBJECTIVE
  Our study is aimed to evaluate the spinal cord pain processing in Huntington's disease (HD) by testing both the temporal summation threshold (TST) of the nociceptive withdrawal reflex (NWR) and the functional activity of the diffuse noxious inhibitory control (DNIC) as form of supraspinal control of pain.
  
  
  METHODS
  We enrolled 19 HD patients and 17 healthy controls. We measured threshold (Th), Area, TST and related psychophysical pain sensations of the NWR, at baseline and during and after activation of the DNIC by means of cold pressor test (CPT) as heterotopic noxious conditioning stimulation.
  
  
  RESULTS
  In HD patients we found a significantly higher Th and TST as well as a lower Area when compared to controls. During the CPT, a significant inhibition of reflex and psychophysical pain responses were found in both HD patients and controls when compared to baseline, without differences between the groups in CPT results.
  
  
  CONCLUSIONS
  Our study demonstrated an abnormal spinal cord pain processing in HD patients. Abnormalities in pain processing are not apparently linked to a dysfunctional DNIC inhibitory projection system in HD patients.
  
  
  CONCLUSIONS
  Our findings support the hypothesis that the striatum could play a role in pain modulation and that its atrophy could affect pain processing without change the DNIC efficiency.
authors.affiliation: Headache and Pain Clinic, IRCCS Mediterranean Neurological Institute Neuromed, Pozzilli, Italy. armando.perrotta@uniroma1.it
authors.forename: Armando
authors.initials: A
authors.lastname: Perrotta
authors.forename: Claudia
authors.initials: C
authors.lastname: Serpino
authors.forename: Claudia
authors.initials: C
authors.lastname: Cormio
authors.forename: Mariano
authors.initials: M
authors.lastname: Serrao
authors.forename: Giorgio
authors.initials: G
authors.lastname: Sandrini
authors.forename: Francesco
authors.initials: F
authors.lastname: Pierelli
authors.forename: Marina
authors.initials: M
authors.lastname: de Tommaso
mesh_terms: D000328:Adult; D000368:Aged; D003342:Corpus Striatum / Q000503:physiopathology; D059328:Diffuse Noxious Inhibitory Control / Q000502:physiology*; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009433:Neural Inhibition / Q000502:physiology; D009619:Nociceptors / Q000502:physiology; D010146:Pain / Q000503:physiopathology*; D010147:Pain Measurement; D017288:Pain Threshold / Q000502:physiology; D013116:Spinal Cord / Q000503:physiopathology*