title: [The type I insulin-like growth factor receptor highly expressed in clonal cells of myelodysplastic syndromes].
abstract: OBJECTIVE
  To probe the expression level of insulin-like growth factor-I receptor (IGF-IR) in malignant clone cells of myelodysplastic syndromes (MDS).
  
  
  METHODS
  The combination of fluorescence in situ hybridization (FISH) and immunochemistry (alkaline phosphatase anti-alkaline phosphatase, APAAP) was used to detect the expression of IGF-IR in the bone marrow cells of 40 MDS patients with abnormal karyotypes.
  
  
  RESULTS
  The average IGF-IR expression level on the clone cells \[(84.5 ± 14.2)%\] from the MDS cases was markedly elevated compared to the corresponding level on normal cells \[(11.4 ± 12.1)%\]. And the percentages of malignant clone cells in all 40 MDS cases were significantly correlated with the relevant percentages of IGF-IR positive nucleated cells (r = 0.929, P < 0.01).
  
  
  CONCLUSIONS
  IGF-IR might be taken as a marker of clone cells in MDS for its trait to malignant proliferation.
authors.affiliation: The Department of Hematology, Shanghai Jiaotong University, Shanghai, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: He
authors.forename: Xiao
authors.initials: X
authors.lastname: Li
authors.forename: Zheng
authors.initials: Z
authors.lastname: Zhang
authors.forename: Qing-xia
authors.initials: QX
authors.lastname: Zhang
authors.forename: Lian-ping
authors.initials: LP
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002999:Clone Cells / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000378:metabolism* / Q000473:pathology; D017526:Receptor, IGF Type 1 / Q000378:metabolism*; D055815:Young Adult
chemical_list: D017526:Receptor, IGF Type 1