title: Phenazines and cancer.
abstract: Phenazines are a large group of natural and synthesised nitrogen-containing heterocycles, including more than 100 different compounds of natural origin and over 6000 synthetic compounds. Many of these compounds have been investigated as potential anti-cancer agents. Despite a large number of research publications, no recent attempt to summarise and critically evaluate the experimental findings relating to the anti-cancer activity of this class of compounds has been made. The present review fills this gap in the literature and discusses both natural and synthetic phenazines with a critical focus on in vitro, in vivo and available clinical anti-cancer activities of these compounds.
authors.affiliation: Dipartimento di Scienze del Suolo, della Pianta, dell'Ambiente e delle Produzioni Animali, Università di Napoli Federico II, Via Università 100, 80055 Portici, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Cimmino
authors.forename: A
authors.initials: A
authors.lastname: Evidente
authors.forename: V
authors.initials: V
authors.lastname: Mathieu
authors.forename: A
authors.initials: A
authors.lastname: Andolfi
authors.forename: F
authors.initials: F
authors.lastname: Lefranc
authors.forename: A
authors.initials: A
authors.lastname: Kornienko
authors.forename: R
authors.initials: R
authors.lastname: Kiss
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D010619:Phenazines / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D010619:Phenazines