title: [Pathogenesis of adhesions formation after intraabdominal operations].
abstract: The article describes the pathogenesis of adhesions formation after intraabdominal operations. Described predisposing factors leading of which is mechanical trauma, resulting from the use of surgical instruments, rough manipulations during surgery, damage to the mesothelium by dry gauze etc, which cause the adhesions. The pathogenesis of adhesions formation after intraabdominal surgery is presented in outline form, which described the changes occurring in the body starting with combination of predisposing factors and ending with the development of adhesions with blood vessels by 7-12 days after surgery. At the genetic level predisposition to adhesions formation and development of adhesive disease is treated as a manifestation of rapid acetylation phenotype, in which the intensity of fibrin formation exceeds normal rate of its catabolism. Thus, according to modem concepts, adhesive disease is a separate nosologic unit that dictates the necessity of its detailed study, development and introduction new universal methods of preventing the adhesions formation after intraabdominal operations.
authors.forename: S É
authors.initials: SÉ
authors.lastname: Voskanian
authors.forename: P S
authors.initials: PS
authors.lastname: Kyzlasov
mesh_terms: D034841:Abdominal Cavity / Q000473:pathology / Q000601:surgery*; D002921:Cicatrix / Q000209:etiology / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D013505:Digestive System Surgical Procedures / Q000009:adverse effects*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D009389:Neovascularization, Pathologic / Q000209:etiology / Q000235:genetics / Q000378:metabolism / Q000503:physiopathology; D011183:Postoperative Complications / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D013997:Time Factors