title: Y-box-binding protein 1 (YB-1) and its functions.
abstract: This review describes the structure and functions of Y-box binding protein 1 (YB-1) and its homologs. Interactions of YB-1 with DNA, mRNAs, and proteins are considered. Data on the participation of YB-1 in DNA reparation and transcription, mRNA splicing and translation are systematized. Results on interactions of YB-1 with cytoskeleton components and its possible role in mRNA localization are discussed. Data on intracellular distribution of YB-1, its redistribution between the nucleus and the cytoplasm, and its secretion and extracellular functions are summarized. The effect of YB-1 on cell differentiation, its involvement in extra- and intracellular signaling pathways, and its role in early embryogenesis are described. The mechanisms of regulation of YB-1 expression in the cell are presented. Special attention is paid to the involvement of YB-1 in oncogenic cell transformation, multiple drug resistance, and dissemination of tumors. Both the oncogenic and antioncogenic activities of YB-1 are reviewed. The potential use of YB-1 in diagnostics and therapy as an early cancer marker and a molecular target is discussed.
authors.affiliation: Institute of Protein Research, Russian Academy of Sciences, Pushchino, Moscow Region, Russia.
authors.forename: I A
authors.initials: IA
authors.lastname: Eliseeva
authors.forename: E R
authors.initials: ER
authors.lastname: Kim
authors.forename: S G
authors.initials: SG
authors.lastname: Guryanov
authors.forename: L P
authors.initials: LP
authors.lastname: Ovchinnikov
authors.forename: D N
authors.initials: DN
authors.lastname: Lyabin
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D047108:Embryonic Development; D005786:Gene Expression Regulation; D006801:Humans; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D017434:Protein Structure, Tertiary; D021381:Protein Transport; D051840:Y-Box-Binding Protein 1 / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism / Q000502:physiology
chemical_list: D051840:Y-Box-Binding Protein 1; C070856:YBX1 protein, human