title: [Protein glycation as a pathological mechanism in diabetes].
abstract: The incidence of diabetes has increased in the recent years. Diabetes is characterized by increased sugar concentrations in the blood. Due to this dysregulation, more carbohydrate-induced modification of proteins - so-called advanced glycation end products (AGEs) - are formed endogenously by non-enzymatic reactions. These are discussed to be at least in part responsible for diabetes-associated diseases. The accumulation of AGEs in the tissue can be used as a biomarker for patient outcome. In contrast, the effects of the uptake of AGEs from nutrition are still unclear.
authors.affiliation: Klinik und Poliklinik für Herz und Thoraxchirurgie, Universitätsklinikum Halle (Saale), Ernst-Grube-Str. 40, 06120, Halle, Deutschland. andreas.simm@medizin.uni-halle.de
authors.forename: A
authors.initials: A
authors.lastname: Simm
authors.forename: A
authors.initials: A
authors.lastname: Navarrete-Santos
authors.forename: B
authors.initials: B
authors.lastname: Hofmann
authors.forename: H
authors.initials: H
authors.lastname: Bushnaq
authors.forename: N
authors.initials: N
authors.lastname: Nass
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D001798:Blood Proteins / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000378:metabolism*; D017127:Glycation End Products, Advanced / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological
chemical_list: D001786:Blood Glucose; D001798:Blood Proteins; D017127:Glycation End Products, Advanced