title: Olfactory deficits and cognitive dysfunction in Parkinson's disease.
abstract: BACKGROUND
  Olfactory deficits and executive dysfunction have been reported in Parkinson's disease (PD). However, the association between these deficits has not been thoroughly examined.
  
  
  METHODS
  We studied 44 PD subjects and 17 age-matched controls. In PD subjects, symptoms were assessed with the Unified Parkinson's Disease Rating Scale and the Hoehn and Yahr scale. Cognition in both groups was assessed by a neuropsychological battery. Olfactory identification and sensitivity was evaluated with the Sniffin' Sticks® test and olfactory detection threshold, respectively.
  
  
  RESULTS
  PD subjects showed significant deficits in olfactory function and working memory, executive function, speed of information processing, visuospatial skills and phonological verbal fluency tests when compared with the control group. Moreover, there was a significant correlation between olfactory sensory deficits and executive dysfunction. In PD patients with up to 12 months of motor symptoms, results were equivalent.
  
  
  CONCLUSIONS
  Our preliminary results suggest a significant association between olfactory deficits and impairments of executive functions in PD.
authors.affiliation: Departamento de Neurología Neurocirugía, Hospital Clínico Universidad de Chile, Santiago, Chile. teresa.parrao@uwa.edu.au
authors.forename: Teresa
authors.initials: T
authors.lastname: Parrao
authors.forename: Pedro
authors.initials: P
authors.lastname: Chana
authors.forename: Pablo
authors.initials: P
authors.lastname: Venegas
authors.forename: María Isabel
authors.initials: MI
authors.lastname: Behrens
authors.forename: María Luz
authors.initials: ML
authors.lastname: Aylwin
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D009483:Neuropsychological Tests; D000857:Olfaction Disorders / Q000175:diagnosis / Q000209:etiology*; D010300:Parkinson Disease / Q000150:complications*; D018709:Statistics, Nonparametric