title: [Preparation and quality control of compound epirubicin hydrochloride-loaded polymeric nanoparticles of L-lactic-co-glycolic acid].
abstract: OBJECTIVE
  To prepare compound epirubicin hydrochloride-loaded polymeric nanoparticles of L-lactic-co-glycolic acid and establish their quality control.
  
  
  METHODS
  The emulsion-solvent evaporation method was employed to prepare and freeze-dry the compound epirubicin hydrochloride-loaded polymeric nanoparticles of L-lactic-co-glycolic acid after the addition of lactose. The contents and cumulative release of epirubicin hydrochloride and dimeglumine gadopentetate were detected simultaneously by RP-HPLC (reverse phase-high performance liquid chromatography).
  
  
  RESULTS
  The above nanoparticles were prepared and the quality standards for simultaneously determining the contents of epirubicin hydrochloride and dimeglumine gadopentetate established primarily. The contents of epirubicin hydrochloride and dimeglumine gadopentetate in compound preparation were 100.6% ± 1.6% and 99.1% ± 1.9% respectively. And two compositions could be completely released within 9 days.
  
  
  CONCLUSIONS
  The preparation method of nanoparticles is simple and their quality control feasible.
authors.affiliation: The Medical School of Southeast University, Postdoctoral Mobile Research Station, Nanjing 210096, China. jjstcty@sina.com
authors.forename: Jian-song
authors.initials: JS
authors.lastname: Ji
authors.forename: Hong-xing
authors.initials: HX
authors.lastname: Fu
authors.forename: Jing-jing
authors.initials: JJ
authors.lastname: Song
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Yan-lin
authors.initials: YL
authors.lastname: Zhu
mesh_terms: D004337:Drug Carriers; D015251:Epirubicin / Q000032:analysis* / Q000138:chemical synthesis*; D019344:Lactic Acid / Q000737:chemistry*; D053758:Nanoparticles; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D004337:Drug Carriers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D015251:Epirubicin