title: [Adult prostate sarcoma: a clinicopathologic study of 15 cases].
abstract: OBJECTIVE
  To clarify the clinical and morphological features of adult prostate sarcoma (APS) and to further improve the knowledge and diagnostic accuracy for APS.
  
  
  METHODS
  Fifteen cases of APS were observed and analyzed on the clinical symptom, pathological features, treatment and prognosis.
  
  
  RESULTS
  Age of onset ranged from 22 to 77 years (mean 46.3 years). The majority of cases were presented with dysuresia. By digital rectal examination and imaging of the prostate, APS was often identified as a large tumor mass. There were 6 cases of leiomyosarcomas, 6 embryonal rhabdomyosarcomas, and 3 fibrosarcomas in this series. Follow-up data were available for 12 cases: 7 cases died of the disease between 9 days and 360 days after surgery. Among 5 survived patients, 3 cases had recurrence after 2 to 24 months follow-up.
  
  
  CONCLUSIONS
  APS is a rare tumor that typically has clinical features: earlier age of onset, fast-appeared urinary tract symptoms, significant mass effects, and poor outcome. Level of prostate specific antigen (PSA) is usually normal or lower. Final diagnosis relies on the features of histology and immunohistochemistry expression profile.
authors.affiliation: Department of Pathology, the First Affiliated Hospital of Nanjing Medical University and Jiangsu Province Hospital, Nanjing 210029, China.
authors.forename: Cong
authors.initials: C
authors.lastname: Wang
authors.forename: Guo-xin
authors.initials: GX
authors.lastname: Song
authors.forename: Wei-ming
authors.initials: WM
authors.lastname: Zhang
authors.forename: Zhi-hong
authors.initials: ZH
authors.lastname: Zhang
authors.forename: Qin-he
authors.initials: QH
authors.lastname: Fan
mesh_terms: D000199:Actins / Q000378:metabolism*; D000328:Adult; D000368:Aged; D003893:Desmin / Q000378:metabolism; D003937:Diagnosis, Differential; D051517:Digital Rectal Examination; D005353:Fibronectins / Q000378:metabolism; D005354:Fibrosarcoma / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D007890:Leiomyosarcoma / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D018008:Myogenin / Q000378:metabolism; D009218:Myosins / Q000378:metabolism; D009364:Neoplasm Recurrence, Local; D017430:Prostate-Specific Antigen / Q000378:metabolism; D011468:Prostatectomy / Q000379:methods; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D018233:Rhabdomyosarcoma, Embryonal / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D012509:Sarcoma / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D015996:Survival Rate; D014746:Vimentin / Q000378:metabolism*; D055815:Young Adult
chemical_list: C541116:ACTA2 protein, human; D000199:Actins; D003893:Desmin; D005353:Fibronectins; D018008:Myogenin; D014746:Vimentin; D017430:Prostate-Specific Antigen; D009218:Myosins