title: Recent advances in the development of cinnamic-like derivatives as antituberculosis agents.
abstract: BACKGROUND
  The high susceptibility of human immunodeficiency virus-infected people to tuberculosis (TB), the emergence of multi-drug-resistant (MDR-TB) strains and extensively drug-resistant (XDR-TB) ones, has brought TB into the focus of urgent scientific interest. As a result, there has been an upsurge in recent years to find new anti-TB agents, with the cinnamoyl moiety having been identified as a particularly simple and effective pharmacophore for this purpose.
  
  
  METHODS
  This review aims at highlighting the potential of (non)natural cinnamic derivatives to treat TB. It provides an overview of the worldwide recent patent and literature surrounding this type of easy-to-prepare small molecules. There is a special focus on their salient structural and chemical features involved in the reported anti-TB activities.
  
  
  CONCLUSIONS
  Cinnamic derivatives clearly appear as attractive drug candidates to combat TB. So far, literature has reported that they are easy to synthesize and have promising anti-TB activities. Nevertheless, the mode(s) of action of these small molecules remain(s) to date obscure, which is why the implicated molecular mechanisms deserve to be investigated in further detail in the near future.
authors.affiliation: Université de Toulouse, UPS, Laboratoire de Synthèse et Physico-Chimie de Molécules d'Intérêt Biologique, 118, Route de Narbonne, F-31062 Toulouse Cedex 9, France.
authors.forename: Prithwiraj
authors.initials: P
authors.lastname: De
authors.forename: Kavita
authors.initials: K
authors.lastname: De
authors.forename: Damien
authors.initials: D
authors.lastname: Veau
authors.forename: Florence
authors.initials: F
authors.lastname: Bedos-Belval
authors.forename: Stefan
authors.initials: S
authors.lastname: Chassaing
authors.forename: Michel
authors.initials: M
authors.lastname: Baltas
mesh_terms: D000818:Animals; D000995:Antitubercular Agents / Q000737:chemistry / Q000494:pharmacology*; D002934:Cinnamates / Q000737:chemistry / Q000494:pharmacology*; D015195:Drug Design; D006801:Humans; D007880:Legislation, Drug; D015394:Molecular Structure; D010330:Patents as Topic; D013329:Structure-Activity Relationship
chemical_list: D000995:Antitubercular Agents; D002934:Cinnamates