title: Is hand-rub consumption correlated with hand hygiene and rate of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE)-acquired infections?
abstract: A retrospective investigation was conducted to determine whether the consumption of alcohol-based hand rub (ABHR) used was correlated with the incidence of acquired nosocomial infection due to meticillin-resistant Staphylococcus aureus or to extended-spectrum beta lactamase (ESBL)-producing strains. Between 2005 and 2008, the use of ABHRs increased significantly by 8 L per 1000 patient-days of hospitalization per year. During the same period, adherence to hand hygiene increased significantly from 55.6% to 70.9% (P < 0.0001). Despite these improvements there was a steady increase in the incidence of ESBL-producing strains in the past three years and no correlation was found between ABHR consumption and either nosocomially acquired ESBL or adherence to hand hygiene.
authors.affiliation: Université Paris Descartes, Faculté de Médecine, CHU - Necker - Enfants Malades, Service Microbiologie - Hygiène Hospitalière, Paris, France. jean-ralph.zahar@nck.aphp.fr
authors.forename: J R
authors.initials: JR
authors.lastname: Zahar
authors.forename: V
authors.initials: V
authors.lastname: Masse
authors.forename: L
authors.initials: L
authors.lastname: Watier
authors.forename: F
authors.initials: F
authors.lastname: Lanternier
authors.forename: N
authors.initials: N
authors.lastname: Degand
authors.forename: M
authors.initials: M
authors.lastname: Postaire
authors.forename: P
authors.initials: P
authors.lastname: Descamps
authors.forename: X
authors.initials: X
authors.lastname: Nassif
authors.forename: O
authors.initials: O
authors.lastname: Lortholary
mesh_terms: D000438:Alcohols / Q000494:pharmacology; D003428:Cross Infection / Q000453:epidemiology* / Q000382:microbiology / Q000517:prevention & control*; D004202:Disinfectants / Q000494:pharmacology; D004363:Drug Utilization / Q000706:statistics & numerical data; D004755:Enterobacteriaceae / Q000201:enzymology* / Q000302:isolation & purification; D004756:Enterobacteriaceae Infections / Q000453:epidemiology* / Q000382:microbiology / Q000517:prevention & control*; D006235:Hand Disinfection / Q000379:methods*; D006801:Humans; D015994:Incidence; D055624:Methicillin-Resistant Staphylococcus aureus / Q000302:isolation & purification; D012189:Retrospective Studies; D013203:Staphylococcal Infections / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control; D001618:beta-Lactamases / Q000378:metabolism*
chemical_list: D000438:Alcohols; D004202:Disinfectants; D001618:beta-Lactamases