title: Antioxidization and antiproliferation of extract from leaves of Toona sinensis.
abstract: OBJECTIVE
  To determine the antioxidization and antiproliferation of extract from leaves of Toona sinensis (LTS).
  
  
  METHODS
  The total phenolic extract of LTS was obtained by solvent and polyamide resin to determine the content. The antioxidization of the LTS extract was measured by TOSC assay. Antiproliferation was studied in vitro with different human cancer cells.
  
  
  RESULTS
  The total phenolic content in the LTS was (427.53±4.31) mg/g and antioxidization was 807.64 μmoL vitamin C equivalents/g in the sample. The extract significantly inhibited the colon cancer cell Caco-2, human liver cancer cell HepG(2) and breast cancer cell MCF-7 proliferation with EC(50) (4.00±0.39), (153.16±13.49) and (193.46±14.68) μg/mL, respectively. The bioactivity index (BI) of the LTS extract was nearly 283. Caco-2 was more sensitive than MCF-7 and HepG(2).
  
  
  CONCLUSIONS
  Extract from LTS has anticancer properties useful for preventing chronic diseases.
authors.affiliation: Department of Food Science, Tianjin Agricultural University, Tianjin, China. f123@tjau.edu.cn
authors.forename: Jinfu
authors.initials: J
authors.lastname: Liu
authors.forename: Lingling
authors.initials: L
authors.lastname: You
authors.forename: Changlu
authors.initials: C
authors.lastname: Wang
authors.forename: Ruihai
authors.initials: R
authors.lastname: Liu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D018938:Caco-2 Cells; D049109:Cell Proliferation / Q000187:drug effects; D056945:Hep G2 Cells; D006801:Humans; D061986:MCF-7 Cells; D029582:Meliaceae / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D010936:Plant Extracts