title: Influence of inhaled beclomethasone and montelukast on airway remodeling in mice.
abstract: This study examined the effect of montelukast and beclomethasone on airway remodeling in murine model of asthma. Mice were sensitized by i.p. injection of ovalbumin (OVA) on days 0 and 14, and then challenged by nebulization of 1% OVA 3 days/week for 6 or 10 weeks. Results of 6-week OVA-challenged group showed moderate inflammation, but the 10-week OVA-challenged group exhibited mild inflammation. The OVA challenge (6 and 10 weeks) exhibited marked airway fibrosis, illustrated by significant increase in goblet cell hyperplasia and epithelial thickness, increased lung content of collagen and transforming growth factor-β(1), together with a decrease in nitric oxide production; also, there was an increase in bronchoalveolar lavage fluid level of interleukin-13. Administration of montelukast or beclomethasone before each OVA challenge was capable of restoring most of the measured parameters to near normal levels. Inhalation of beclomethasone has a similar role in airway remodeling as montelukast, but its effects in regulating inflammatory changes is less pronounced than montelukast.
authors.affiliation: Department of Pharmacology and Toxicology, Faculty of Pharmacy, Mansoura University, Mansoura, 35516, Egypt. rania200582@yahoo.com
authors.forename: Rania R
authors.initials: RR
authors.lastname: Abdel Aziz
authors.forename: Nadia Y
authors.initials: NY
authors.lastname: Helaly
authors.forename: Khaled R
authors.initials: KR
authors.lastname: Zalata
authors.forename: Nariman M
authors.initials: NM
authors.lastname: Gameil
mesh_terms: D000085:Acetates / Q000008:administration & dosage / Q000494:pharmacology*; D000280:Administration, Inhalation; D056151:Airway Remodeling / Q000187:drug effects; D000818:Animals; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D001507:Beclomethasone / Q000008:administration & dosage / Q000494:pharmacology*; D003521:Cyclopropanes; D004195:Disease Models, Animal; D007249:Inflammation / Q000188:drug therapy / Q000473:pathology; D008297:Male; D051379:Mice; D010047:Ovalbumin; D011804:Quinolines / Q000008:administration & dosage / Q000494:pharmacology*; D012720:Severity of Illness Index; D013440:Sulfides; D013997:Time Factors
chemical_list: D000085:Acetates; D018927:Anti-Asthmatic Agents; D003521:Cyclopropanes; D011804:Quinolines; D013440:Sulfides; D010047:Ovalbumin; D001507:Beclomethasone; C093875:montelukast