title: Comparative evaluation of autologous platelet-rich fibrin and platelet-rich plasma in the treatment of 3-wall intrabony defects in chronic periodontitis: a randomized controlled clinical trial.
abstract: BACKGROUND
  The topical use of platelet concentrates is recent, and its efficiency remains controversial. The present study aims to explore the clinical and radiographic effectiveness of autologous platelet-rich fibrin (PRF) and platelet-rich plasma (PRP) in the treatment of intrabony defects in patients with chronic periodontitis.
  
  
  METHODS
  Ninety intrabony defects were treated with either autologous PRF with open-flap debridement or autologous PRP with open-flap debridement or open-flap debridement alone. Clinical and radiologic parameters, such as probing depth (PD), clinical attachment level (CAL), intrabony defect depth, and percentage defect fill, were recorded at baseline and 9 months postoperatively.
  
  
  RESULTS
  Mean PD reduction and CAL gain were greater in PRF (3.77 ± 1.19 and 3.17 ± 1.29 mm) and PRP (3.77 ± 1.07 and 2.93 ± 1.08 mm) groups than the control group (2.97 ± 0.93 and 2.83 ± 0.91 mm). Furthermore, significantly greater percentage of mean bone fill was found in the PRF (55.41% ± 11.39%) and PRP (56.85% ± 14.01%) groups compared with the control (1.56% ± 15.12%) group.
  
  
  CONCLUSIONS
  Within the limit of the present study, there was similar PD reduction, CAL gain, and bone fill at sites treated with PRF or PRP with conventional open-flap debridement. Because PRF is less time consuming and less technique sensitive, it may seem a better treatment option than PRP. However, long-term, multicenter randomized, controlled clinical trials will be required to know their clinical and radiographic effects on bone regeneration.
authors.affiliation: Department of Periodontics, Government Dental College and Research Institute, Bangalore, India. periodonticsgdcri@gmail.com
authors.forename: A R
authors.initials: AR
authors.lastname: Pradeep
authors.forename: Nishanth S
authors.initials: NS
authors.lastname: Rao
authors.forename: Esha
authors.initials: E
authors.lastname: Agarwal
authors.forename: Pavan
authors.initials: P
authors.lastname: Bajaj
authors.forename: Minal
authors.initials: M
authors.lastname: Kumari
authors.forename: Savitha B
authors.initials: SB
authors.lastname: Naik
mesh_terms: D000328:Adult; D016301:Alveolar Bone Loss / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000601:surgery; D001861:Bone Regeneration / Q000187:drug effects*; D055113:Chronic Periodontitis / Q000188:drug therapy* / Q000601:surgery; D004311:Double-Blind Method; D005260:Female; D005337:Fibrin / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D017622:Periodontal Attachment Loss / Q000188:drug therapy / Q000601:surgery; D057747:Periodontal Debridement; D010512:Periodontal Index; D010982:Platelet-Derived Growth Factor / Q000008:administration & dosage* / Q000627:therapeutic use; D053657:Platelet-Rich Plasma / Q000737:chemistry / Q000502:physiology; D011446:Prospective Studies; D011859:Radiography
chemical_list: D010982:Platelet-Derived Growth Factor; D005337:Fibrin