title: Primary hepatic lymphoma in a patient with previous rectal adenocarcinoma: a case report and discussion of etiopathogenesis and diagnostic tools.
abstract: Primary hepatic lymphoma is an extremely rare malignancy accounting for 0.016% of all cases of non-Hodgkin lymphomas. Approximately 1-4% of histologies described show a follicular pattern. We report a case of primary hepatic non-Hodgkin lymphoma that developed in a middle-aged woman 3 years after radical treatment (neoadjuvant chemoradiotherapy and surgery) for a rectal adenocarcinoma. Abdomen ultrasound showed a single nodule in the liver, which raised the issue of differential diagnosis with a metastasis from rectal cancer. After surgical removal of the nodule, histology revealed a primary B cell, stage IE follicular non-Hodgkin lymphoma, confined to the liver; indeed, no foci of lymphoma were found elsewhere in the body.
authors.affiliation: Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica, Università di Napoli Federico II, Via Sergio Pansini 5, 80131 Naples, Italy.
authors.forename: Lucia
authors.initials: L
authors.lastname: Raimondo
authors.forename: Idalucia
authors.initials: I
authors.lastname: Ferrara
authors.forename: Alfonso De
authors.initials: AD
authors.lastname: Stefano
authors.forename: Chiara Alessandra
authors.initials: CA
authors.lastname: Cella
authors.forename: Francesco Paolo
authors.initials: FP
authors.lastname: D'Armiento
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Ciancia
authors.forename: Roberto
authors.initials: R
authors.lastname: Moretto
authors.forename: Amalia De
authors.initials: AD
authors.lastname: Renzo
authors.forename: Chiara
authors.initials: C
authors.lastname: Carlomagno
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000473:pathology*; D001706:Biopsy; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D008875:Middle Aged; D009367:Neoplasm Staging; D016609:Neoplasms, Second Primary / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D012004:Rectal Neoplasms / Q000188:drug therapy / Q000473:pathology*; D016896:Treatment Outcome