title: [Application of multiple tumor markers's protein chip in the screen program of the elderly].
abstract: OBJECTIVE
  To evaluate the application of the multiple tumor markers's protein chip (C12 chip) in the screen program of the elderly.
  
  
  METHODS
  The C12 chip included alpha-fetoprotein (AFP), neuron-specific enolase (NSE), prostate special antigen (PSA), free-PSA (f-PSA), carcinoembryonic antigen (CEA), carbohydrate antigen 125 (CA125), carbohydrate antigen 153 (CA153), carbohydrate antigen 199 (CA199), carbohydrate antigen 242 (CA242), human chorionic gonadotropin-beta (β-HCG), human growth hormone (HGH)and ferritin. The sera of the 399 healthy elderly under the screening program and 1791 adults were detected by the C12 chip. Definition of positive was set as: one or more tumor markers higher than or equal to the reference value.
  
  
  RESULTS
  The positive rates of AFP, PSA, f-PSA, CEA, CA125, CA153 and CA199 between the elderly group and the adult group were significantly different (P < 0.05). The normal test value of AFP, PSA, f-PSA, CEA, CA125, CA199, CA242 and ferritin between the elderly group and the adult group were significantly different (P < 0.05).
  
  
  CONCLUSIONS
  AFP, PSA, f-PSA, CEA, CA125, CA153 and CA199 of the C12 chip were useful in the screening program of the elderly to discover the sign of tumor at an early stage.
authors.affiliation: Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510520, China.
authors.forename: Hai-yan
authors.initials: HY
authors.lastname: Yan
authors.forename: Ri-hui
authors.initials: RH
authors.lastname: Zhong
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Xiao-hong
authors.initials: XH
authors.lastname: Luo
authors.forename: Rui
authors.initials: R
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000951:Antigens, Neoplasm / Q000097:blood*; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood*; D018394:CA-125 Antigen / Q000097:blood; D018395:CA-19-9 Antigen / Q000097:blood; D002272:Carcinoembryonic Antigen / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D009098:Multiphasic Screening / Q000379:methods*; D010751:Phosphopyruvate Hydratase / Q000097:blood; D040081:Protein Array Analysis; D055815:Young Adult; D000509:alpha-Fetoproteins
chemical_list: D000951:Antigens, Neoplasm; D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; C074601:CA 242 antigen; D018394:CA-125 Antigen; D018395:CA-19-9 Antigen; D002272:Carcinoembryonic Antigen; D000509:alpha-Fetoproteins; D010751:Phosphopyruvate Hydratase