title: Biomimetic scaffolds:  implications for craniofacial regeneration.
abstract: With the advancement in stem cell research and material science, tissue regeneration has been evolved from scientific hypothesis to clinical reality and thus will have a great potential in regenerating craniofacial tissue. In this approach, scaffold plays an essential role in tissue regeneration by recruiting host regenerative cells or enhancing adhesion, proliferation and matrix production of seeded cells, and eventual formation of the desired tissue type. Moreover, incorporation of biomimesis concept into scaffold design and manufacture will further enhance the quality and function of regenerated tissues. This article summarizes new developments of biomimetic scaffolds including the biomimesis of extracellular matrix, cell-matrix interaction, and tissue-regenerative signaling.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Tissue Engineering Key Laboratory, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Yuan
authors.forename: Yilin
authors.initials: Y
authors.lastname: Cao
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
mesh_terms: D000595:Amino Acid Sequence; D001696:Biomechanical Phenomena; D040761:Biomimetic Materials / Q000737:chemistry*; D001854:Bone Marrow Cells / Q000502:physiology; D001857:Bone Matrix / Q000502:physiology; D001861:Bone Regeneration / Q000502:physiology*; D018786:Bone Substitutes / Q000737:chemistry; D002130:Calcium Phosphates / Q000737:chemistry; D002448:Cell Adhesion / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D049109:Cell Proliferation; D021982:Cell-Matrix Junctions / Q000502:physiology; D048271:Chitosan / Q000737:chemistry; D003094:Collagen / Q000737:chemistry; D017886:Durapatite / Q000737:chemistry; D005109:Extracellular Matrix / Q000502:physiology; D005147:Facial Bones / Q000601:surgery*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000627:therapeutic use; D009842:Oligopeptides / Q000737:chemistry; D010012:Osteogenesis / Q000502:physiology; D019651:Plastic Surgery Procedures / Q000379:methods*; D015398:Signal Transduction / Q000502:physiology; D012886:Skull / Q000601:surgery*; D017154:Stromal Cells / Q000502:physiology; D013499:Surface Properties; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds
chemical_list: D018786:Bone Substitutes; D002130:Calcium Phosphates; D036341:Intercellular Signaling Peptides and Proteins; D009842:Oligopeptides; C047981:arginyl-glycyl-aspartic acid; D003094:Collagen; D048271:Chitosan; D017886:Durapatite; C020243:calcium phosphate