title: Platelet function and signaling in diabetes mellitus.
abstract: Diabetes mellitus is associated with the accelerated development of vascular disease and there is evidence that platelets actively contribute to this process. Certainly, platelets are able to modulate the function of endothelial and vascular smooth muscle cells via the direct release of growth factors and pro-inflammatory chemokines but also via the production of microparticles which function as a transcellular delivery system for micro RNAs. This article reviews the intracellular signaling mechanisms underlying the increased activation of diabetic platelets and the involvement of platelets in atherothrombosis development.
authors.affiliation: Institute for Vascular Signalling, Centre for Molecular Medicine, Johann Wolfgang Goethe University, Theodor-Stern-Kai 7, D-60596 Frankfurt am Main, Germany. voahangy@vrc.uni-frankfurt.de
authors.forename: Voahanginirina
authors.initials: V
authors.lastname: Randriamboavonjy
authors.forename: Ingrid
authors.initials: I
authors.lastname: Fleming
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000378:metabolism*; D055252:Cell-Derived Microparticles / Q000378:metabolism; D018925:Chemokines / Q000378:metabolism; D003920:Diabetes Mellitus / Q000503:physiopathology*; D003925:Diabetic Angiopathies / Q000503:physiopathology*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D035683:MicroRNAs / Q000378:metabolism; D032389:Myocytes, Smooth Muscle / Q000378:metabolism; D015539:Platelet Activation; D015398:Signal Transduction; D013927:Thrombosis / Q000209:etiology / Q000473:pathology
chemical_list: D018925:Chemokines; D036341:Intercellular Signaling Peptides and Proteins; D035683:MicroRNAs