title: Novel peptide-shelled dendrimer with dramatically changeable thermo-responsive character.
abstract: The preparation of a novel peptide/dendrimer hybrid is reported in which an elastin-like oligopeptide is successfully assembled onto a poly(amidoamine) dendrimer surface (G4-ELP), and its unique thermo-responsive behavior is discussed. As a result, the G4-ELP is found to exhibit LCST behavior in the pH range 3-10 including physiological temperature range under neutral-pH conditions. Moreover, cooperative interplay between the folding state of the ELP shell and the ionization state of the dendrimer core enables the G4-ELP to control its LCST widely by pH variation. This achievement provides a new insight for the design of dual-responsive materials with a potential in biological applications.
authors.affiliation: Department of Molecular Chemistry & Biochemistry, Faculty of Science & Engineering, Doshisha University, Kyotanabe, Kyoto 610-0321, Japan. tkoga@mail.doshisha.ac.jp
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Koga
authors.forename: Masayuki
authors.initials: M
authors.lastname: Iimura
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Higashi
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis*; D050091:Dendrimers / Q000737:chemistry*; D004549:Elastin; D006863:Hydrogen-Ion Concentration; D008823:Micelles; D008968:Molecular Conformation; D018716:Molecular Mimicry; D010455:Peptides / Q000737:chemistry*; D013696:Temperature
chemical_list: D001672:Biocompatible Materials; D050091:Dendrimers; D008823:Micelles; C104700:PAMAM Starburst; D010455:Peptides; D004549:Elastin