title: Fibrils and nanotubes assembled from a modified amyloid-β peptide fragment differ in the packing of the same β-sheet building blocks.
abstract: The peptide AAKLVFF assembles into fibrils in water and nanotubes in methanol. Solid-state NMR data are consistent with fibrils constructed from β-sheet bilayers and nanotubes bounded by a wall of offset β-sheet monolayers. Remarkably distinct morphologies are thus traced to subtle differences in the arrangement of the same fundamental building blocks.
authors.affiliation: Department of Structural and Chemical Biology, University of Liverpool, Crown Street, Liverpool, UK.
authors.forename: Jillian
authors.initials: J
authors.lastname: Madine
authors.forename: Hannah A
authors.initials: HA
authors.lastname: Davies
authors.forename: Christopher
authors.initials: C
authors.lastname: Shaw
authors.forename: Ian W
authors.initials: IW
authors.lastname: Hamley
authors.forename: David A
authors.initials: DA
authors.lastname: Middleton
mesh_terms: D016229:Amyloid beta-Peptides / Q000737:chemistry* / Q000648:ultrastructure; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D046529:Microscopy, Electron, Transmission; D043942:Nanotubes / Q000737:chemistry* / Q000648:ultrastructure; D010446:Peptide Fragments / Q000737:chemistry* / Q000648:ultrastructure; D017433:Protein Structure, Secondary; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: C559205:AAKLVFF; D016229:Amyloid beta-Peptides; D010446:Peptide Fragments