title: Correlation between circulating angiogenic cell mobilizations and recovery of coronary flow reserve in patients with acute myocardial infarction.
abstract: BACKGROUND
  The correlations between circulating angiogenic cell mobilizations and improvement of microvascular integrity were investigated in patients (n=110) with acute myocardial infarction (AMI) during an 8-month follow up.
  
  
  RESULTS
  Coronary flow reserve (CFR) was measured at baseline and at 8 months by using an intracoronary Doppler wire. Serial changes in the absolute numbers of circulating angiogenic cells such as CD34+, CXCR4+, CD117+, CD133+ and C-met+ were measured at baseline, day 1, day 5 and at 8 months. The absolute numbers of circulating angiogenic cells at day 1 were significantly higher than those at baseline. A positive correlation was found between the numbers of circulating angiogenic cells of CD34+, CXCR4+, CD117+ and CD133+ cells at day 1 and the CFR changes from baseline. The cut-off value of CFR changes at 8 months by a receiver operating characteristic curve between a circulating CD34+ cell at day 1 and changes of CFR at 8 months was 0. Late-loss showed the positive correlation with the absolute number of C-met+ cells and the negative correlation with the absolute number of CXCR4+ cells after AMI. The negative correlation was found between changes in high-sensitive C-reactive protein and soluble intercellular adhesion molecule-1 and changes in CFR at 8 months.
  
  
  CONCLUSIONS
  The recovery of microvascular integrity after acute ischemic injury was expedited by the increases in circulating angiogenic cell mobilization together with the greater decreases in inflammatory cytokines. The improvement in CFR could be predicted by the measurement of circulating angiogenic cells after AMI.
authors.affiliation: Department of Cardiology, Cardiovascular Center, Korea University Anam Hospital, Seoul, Korea.
authors.forename: Han Saem
authors.initials: HS
authors.lastname: Jeong
authors.forename: Soon Jun
authors.initials: SJ
authors.lastname: Hong
authors.forename: Jae Hyoung
authors.initials: JH
authors.lastname: Park
authors.forename: Jong-Ho
authors.initials: JH
authors.lastname: Kim
authors.forename: Seung Cheol
authors.initials: SC
authors.lastname: Choi
authors.forename: Chul-Min
authors.initials: CM
authors.lastname: Ahn
authors.forename: Je Sang
authors.initials: JS
authors.lastname: Kim
authors.forename: Do-Sun
authors.initials: DS
authors.lastname: Lim
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000097:blood; D003326:Coronary Circulation; D016207:Cytokines / Q000097:blood; D005260:Female; D019650:Hematopoietic Stem Cell Mobilization; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy; D011446:Prospective Studies; D019718:Receptors, CXCR4 / Q000097:blood; D013234:Stem Cells / Q000378:metabolism* / Q000473:pathology; D013997:Time Factors
chemical_list: D015703:Antigens, CD; C527276:CXCR4 protein, human; D016207:Cytokines; D019718:Receptors, CXCR4