title: Highly efficient asymmetric aldol reaction in brine using a fluorous sulfonamide organocatalyst.
abstract: A fluorous organocatalyst promotes direct asymmetric aldol reactions of aromatic aldehydes with ketones in brine to afford the corresponding anti-aldol products in high yield with up to 96% ee. Fluorous organocatalyst can be readily recovered by solid phase extraction using fluorous silica gel and reused without purification.
authors.affiliation: Gifu Pharmaceutical University 1-25-4, Daigaku-nishi, Gifu 501-1196, Japan. miura@gifu-pu.ac.jp
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Miura
authors.forename: Hikaru
authors.initials: H
authors.lastname: Kasuga
authors.forename: Kie
authors.initials: K
authors.lastname: Imai
authors.forename: Mariko
authors.initials: M
authors.lastname: Ina
authors.forename: Norihiro
authors.initials: N
authors.lastname: Tada
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Imai
authors.forename: Akichika
authors.initials: A
authors.lastname: Itoh
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D017611:Fluorine Compounds / Q000737:chemistry*; D015394:Molecular Structure; D012492:Salts / Q000737:chemistry*; D013237:Stereoisomerism; D013449:Sulfonamides / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D017611:Fluorine Compounds; D012492:Salts; D013449:Sulfonamides; C017082:brine; C116609:3-hydroxybutanal