title: Current and future microbicide approaches aimed at preventing HIV infection in women.
abstract: Women from developing countries, in which the prevalence of HIV infection is very high, are at risk of becoming infected without having the possibility of personally controlling this risk. Therefore, there is an urgent need to develop anti-HIV vaginal microbicide strategies. This review considers the modes of entry of HIV through the mucosa of the female genital tract, the different classes of vaginal microbicide compounds, the mode of delivery of these drugs, the aims and methods of in vitro and animal experiments at the preclinical stage, the results of the Phase III trials conducted in different countries, including the ongoing assays, and the future orientations for the next 5 years with a discussion relative to antiviral resistance, combination strategies and development of new-generation compounds.
authors.affiliation: Groupe Immunité des Muqueuses et Agents Pathogènes, PRES de Lyon, Université Jean Monnet, IFRESIS et CHU de Saint-Etienne, 42023 Saint-Etienne cedex 02, France. bruno.pozzetto@univ-st-etienne.fr
authors.forename: Bruno
authors.initials: B
authors.lastname: Pozzetto
authors.forename: Olivier
authors.initials: O
authors.lastname: Delézay
authors.forename: Amandine
authors.initials: A
authors.lastname: Brunon-Gagneux
authors.forename: Hind
authors.initials: H
authors.lastname: Hamzeh-Cognasse
authors.forename: Frédéric
authors.initials: F
authors.lastname: Lucht
authors.forename: Thomas
authors.initials: T
authors.lastname: Bourlet
mesh_terms: D000282:Administration, Intravaginal; D000293:Adolescent; D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage*; D017326:Clinical Trials, Phase III as Topic; D003267:Contraception / Q000379:methods; D003274:Contraceptive Devices, Female; D003906:Developing Countries; D005260:Female; D006678:HIV / Q000187:drug effects* / Q000502:physiology; D015658:HIV Infections / Q000188:drug therapy / Q000517:prevention & control* / Q000821:virology; D006801:Humans; D009092:Mucous Membrane / Q000187:drug effects* / Q000821:virology; D015728:Receptors, HIV / Q000037:antagonists & inhibitors / Q000378:metabolism; D014621:Vagina / Q000187:drug effects* / Q000821:virology; D014622:Vaginal Creams, Foams, and Jellies / Q000008:administration & dosage*; D053586:Virus Internalization / Q000187:drug effects
chemical_list: D019380:Anti-HIV Agents; D015728:Receptors, HIV; D014622:Vaginal Creams, Foams, and Jellies