title: Myc proteins in brain tumor development and maintenance.
abstract: Myc proteins are often deregulated in human brain tumors, especially in embryonal tumors that affect children. Many observations have shown how alterations of these pleiotropic Myc transcription factors provide initiation, maintenance, or progression of tumors. This review will focus on the role of Myc family members (particularly c-myc and Mycn) in tumors like medulloblastoma and glioma and will further discuss how to target stabilization of these proteins for future brain tumor therapies.
authors.affiliation: Uppsala University, Department of Immunology, Genetics, and Pathology, Rudbeck Laboratory, Uppsala, Sweden. fredrik.swartling@igp.uu.se
authors.forename: Fredrik J
authors.initials: FJ
authors.lastname: Swartling
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D001932:Brain Neoplasms / Q000473:pathology* / Q000503:physiopathology; D005909:Glioblastoma / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D008527:Medulloblastoma / Q000473:pathology* / Q000503:physiopathology; D051379:Mice; D009154:Mutation; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction
chemical_list: D016271:Proto-Oncogene Proteins c-myc