title: Atypical granular cell tumor occurring in an individual with Noonan syndrome treated with growth hormone.
abstract: We report a large infiltrating atypical granular cell tumor in a child with Noonan syndrome. Even though granular cell tumors are rare in childhood, five cases have been reported in children with Noonan syndrome. This study compares these different cases and explores the possibility of activation of the granular cell by the Ras pathway.
authors.affiliation: Dermatology Service, Centre Hospitalier de Valence, Valence, France.
authors.forename: D
authors.initials: D
authors.lastname: Moos
authors.forename: C
authors.initials: C
authors.lastname: Droitcourt
authors.forename: D
authors.initials: D
authors.lastname: Rancherevince
authors.forename: P
authors.initials: P
authors.lastname: Marec Berard
authors.forename: F
authors.initials: F
authors.lastname: Skowron
mesh_terms: D002648:Child; D005260:Female; D016586:Granular Cell Tumor / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology / Q000601:surgery; D019382:Human Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D009154:Mutation; D009634:Noonan Syndrome / Q000188:drug therapy* / Q000235:genetics; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11 / Q000235:genetics; D016896:Treatment Outcome
chemical_list: D019382:Human Growth Hormone; C516724:PTPN11 protein, human; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11