title: Cotard's syndrome with glioblastoma multiforme.
abstract: OBJECTIVE
  Brain tumors are classically associated with neurological and/or psychiatric symptomatology. Behavioral or cognitive disorders can underlie delirium, personality changes, psychotic reactions, and mood disorders.
  
  
  METHODS
  To illustrate this, we report the case of a 60-year-old male patient confronted with an inoperable glioblastoma multiforme on the splenium of the corpus callosum, of poor prognosis, treated by concomitant radiochemotherapy with temozolomide, who developed psychotic depression with Cotard's syndrome. Clinical manifestations of this syndrome with untoward consequences in terms of prognosis are classically characterized by intense moral suffering, indignity and pessimistic fixations, suicidal ideations, and a nihilistic delusion relating to one's own body.
  
  
  RESULTS
  Nevertheless, this association between Cotard's syndrome and glioblastoma has been seldom described. To our knowledge, this is the first time that this has been described as a complication of this particular tumor location. Some neuropsychopathological hypotheses are proposed, which involve medical, iatrogenic, and psychogenesis issues.
  
  
  CONCLUSIONS
  This case report points to the necessary collaboration between psychiatrists, neuro-oncologists and radiation oncologists in improving the patient's management and quality of life.
authors.affiliation: Psycho-oncology Team, Centre Oscar Lambret, Lille, France.
authors.forename: Michel
authors.initials: M
authors.lastname: Reich
authors.affiliation: Department of Radiotherapy, Centre Oscar Lambret, Lille, France.
authors.forename: Benedicte
authors.initials: B
authors.lastname: Comet
authors.affiliation: Neurology, Breast Cancer Unit, Centre Oscar Lambret, Lille, France.
authors.forename: Emilie
authors.initials: E
authors.lastname: Le Rhun
authors.affiliation: Department of Neuro-oncology and Neurosurgery, Roger Salengro Hospital, Lille University Medical Center, Lille, France.
authors.forename: Carole
authors.initials: C
authors.lastname: Ramirez
mesh_terms: D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000150:complications* / Q000523:psychology / Q000628:therapy; D059248:Chemoradiotherapy / Q000009:adverse effects*; D003131:Combined Modality Therapy; D003337:Corpus Callosum / Q000473:pathology; D003606:Dacarbazine / Q000031:analogs & derivatives / Q000627:therapeutic use; D003702:Delusions / Q000209:etiology*; D003865:Major Depressive Disorder / Q000209:etiology*; D005909:Glioblastoma / Q000150:complications* / Q000523:psychology / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011618:Psychotic Disorders / Q000209:etiology*; D013406:Suicide, Attempted; D013577:Syndrome; D000077204:Temozolomide
chemical_list: D018906:Antineoplastic Agents, Alkylating; D003606:Dacarbazine; D000077204:Temozolomide