title: Concise one-pot preparation of unique bis-pyrrolidinone tetrazoles.
abstract: A one-pot, two-step synthesis of bis-pyrrolidinone tetrazoles has been established via the Ugi-Azide reaction using methyl levulinate, primary amines, isocyanides and azidotrimethylsilane with subsequent acid treatment to catalyze the lactam formation. The efficiency of the protocol was established followed by a successful transition to library production in four 24-well plates.
authors.forename: Steven
authors.initials: S
authors.lastname: Gunawan
authors.forename: Joachim
authors.initials: J
authors.lastname: Petit
authors.forename: Christopher
authors.initials: C
authors.lastname: Hulme
mesh_terms: D001386:Azides / Q000737:chemistry; D015394:Molecular Structure; D011760:Pyrrolidinones / Q000138:chemical synthesis* / Q000737:chemistry; D012821:Silanes / Q000737:chemistry; D013777:Tetrazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001386:Azides; D011760:Pyrrolidinones; D012821:Silanes; D013777:Tetrazoles; C438544:azidotrimethylsilane