title: DLK1-MEG3 imprinted domain microRNAs in cancer biology.
abstract: A rapidly growing body of evidence highlights the involvement of DLK1-MEG3 imprinted domain in cell biology and cancer pathogenesis. The imprinted domain contains protein-coding genes, long non-coding RNAs, and various small non-coding RNAs. The imprinted microRNAs located here interact with important transcription factors, modulate fundamental signaling cascades, form molecular signatures with diagnostic and prognostic potential, and could differentiate chemoresistant from chemosensitive disease. Moreover, as they can be detected in patients' serum, are easy to obtain, and can be used as adjuvant diagnostic biomarkers with the potential of monitoring disease progression and response to treatment.
authors.affiliation: Transfusion Unit, General Hospital of Preveza, Preveza, Greece. benetatosleon@yahoo.com
authors.forename: Leonidas
authors.initials: L
authors.lastname: Benetatos
authors.forename: Evangelos
authors.initials: E
authors.lastname: Voulgaris
authors.forename: George
authors.initials: G
authors.lastname: Vartholomatos
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000097:blood / Q000235:genetics*; D002135:Calcium-Binding Proteins; D018392:Genomic Imprinting; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood / Q000235:genetics*; D008565:Membrane Proteins / Q000097:blood / Q000235:genetics*; D051379:Mice; D035683:MicroRNAs / Q000097:blood / Q000235:genetics*; D009369:Neoplasms / Q000737:chemistry / Q000235:genetics*; D011506:Proteins / Q000032:analysis / Q000235:genetics*; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated / Q000097:blood / Q000235:genetics*
chemical_list: D014408:Biomarkers, Tumor; D002135:Calcium-Binding Proteins; C512941:DLK1 protein, human; D036341:Intercellular Signaling Peptides and Proteins; C498907:MEG3 non-coding RNA, human; D008565:Membrane Proteins; D035683:MicroRNAs; D011506:Proteins; D062085:RNA, Long Noncoding; D022661:RNA, Untranslated