title: Absorbable bandage wrapping in treatment of severe blast liver injury: a miniature swine model.
abstract: BACKGROUND
  The aim of this research was to evaluate the feasibility and efficacy of absorbable bandage wrapping in the treatment of cases of severe liver trauma.
  
  
  METHODS
  Electric firecrackers were detonated in 16 miniature swine to produce a severe blast liver injury. After fluid resuscitation, the animals were randomly divided into two groups (n = 8 each) and were either treated with absorbable bandage wrapping of the injured lobe of liver (Group B) or hepatic lobectomy (Group H). Time to hemostasis, blood loss during the treatment period, and other parameters were compared, including postoperative serum total bilirubin (TB), alanine aminotransferase (ALT), and aspartate aminotransferase (AST).
  
  
  RESULTS
  Blood loss during the treatment period was significantly lower in Group B than that in Group H ((81.3 ± 26.0) ml vs. (130.8 ± 29.5) ml, P = 0.0031). Serum AST and ALT were transiently increased post-surgically. These transient increases were significantly higher in Group B. No difference in time to hemostasis was noted ((8.70 ± 2.27) minutes vs. (10.28 ± 1.93) minutes, P = 0.1559) in Groups B and H, respectively. Two pigs were humanely euthanized 28 days post-surgically and the wrapped liver lobes appeared atrophies. Microscopically, there was evidence of emerging and mature fibrous tissue.
  
  
  CONCLUSIONS
  Absorbable bandage wrapping is both feasible and effective in the treatment of severe blast liver injury.
authors.affiliation: Department of General Surgery, Chinese People's Liberation Army General Hospital, Beijing 100853, China.
authors.forename: Can-Rong
authors.initials: CR
authors.lastname: Lu
authors.forename: Lin
authors.initials: L
authors.lastname: Chen
authors.forename: Wen-Bin
authors.initials: WB
authors.lastname: Chen
authors.forename: Chun-Qing
authors.initials: CQ
authors.lastname: Dou
authors.forename: Rong
authors.initials: R
authors.lastname: Liu
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Huang
mesh_terms: D000818:Animals; D001458:Bandages; D005260:Female; D008099:Liver / Q000293:injuries* / Q000601:surgery*; D008297:Male; D013552:Swine; D013556:Swine, Miniature