title: Expedient synthesis of highly substituted pyrroles via tandem rearrangement of α-diazo oxime ethers.
abstract: An efficient rhodium-catalyzed synthesis of 2H-azirines and pyrroles has been developed. Novel rearrangement of α-oximino ketenes derived from α-diazo oxime ethers provides 2H-azirines bearing quaternary centers and allows for subsequent rearrangement to highly substituted pyrroles in excellent yields.
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore.
authors.forename: Yaojia
authors.initials: Y
authors.lastname: Jiang
authors.forename: Wei Chuen
authors.initials: WC
authors.lastname: Chan
authors.forename: Cheol-Min
authors.initials: CM
authors.lastname: Park
mesh_terms: D001391:Azo Compounds / Q000737:chemistry*; D004987:Ethers / Q000737:chemistry*; D015394:Molecular Structure; D010091:Oximes / Q000737:chemistry*; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D001391:Azo Compounds; D004987:Ethers; D010091:Oximes; D011758:Pyrroles