title: [Relationship between rs3865418 polymorphism of neural precursor cell expressed developmentally downregulated 4-like gene and obesity in Kazakh general population].
abstract: OBJECTIVE
  To investigate the relationships between rs3865418 polymorphism of neural precursor cell expressed developmentally downregulated 4-like gene and obesity in Kazakh general population.
  
  
  METHODS
  Based on a cross-sectional epidemiological study in a Kazakh general population, a case-control study was conducted. The rs3865418 polymorphism in a Kazakh general population (856 subjects, including 364 males and 492 females; 478 in obesity group and 378 in normal control group) was genotyped by TaqMan polymerase chain reaction, and the relationship between rs3865418 polymorphism and obesity was analyzed.
  
  
  RESULTS
  The rs3865418 polymorphism was successfully genotyped in 851 Kazakh subjects. The distribution of the genotypes and alleles of rs3865418 polymorphism did not differ significantly between the obesity group and normal control group in terms of general populations, males, and females (all P > 0.05). The waist circumference showed a tendency of C/C > C/T > T/T in males and C/C < C/T < T/T in females, but without statistical significance (P > 0.05).
  
  
  CONCLUSIONS
  The rs3865418 polymorphism of neural precursor cell expressed developmentally downregulated 4-like gene may not be associated with obesity in Kazakh general population. In other words, it is not a predisposing factor for obesity in Kazakh.
authors.affiliation: Graduate School of Xinjiang Medical University, Urumqi 830054, China.
authors.forename: Hong-Mei
authors.initials: HM
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: Hong
authors.forename: Wen-Li
authors.initials: WL
authors.lastname: Luo
authors.forename: Jian-Hang
authors.initials: JH
authors.lastname: Chang
authors.forename: Xiao-Guang
authors.initials: XG
authors.lastname: Yao
authors.forename: Nan-Fang
authors.initials: NF
authors.lastname: Li
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D003430:Cross-Sectional Studies; D056827:Endosomal Sorting Complexes Required for Transport / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D000075702:Nedd4 Ubiquitin Protein Ligases; D009765:Obesity / Q000235:genetics*; D011110:Polymorphism, Genetic; D044767:Ubiquitin-Protein Ligases / Q000235:genetics*
chemical_list: D056827:Endosomal Sorting Complexes Required for Transport; D000075702:Nedd4 Ubiquitin Protein Ligases; D044767:Ubiquitin-Protein Ligases