title: Social behavior impairment in offspring exposed to maternal seizures in utero.
abstract: Human and animal models have demonstrated that maternal seizures in utero could be deleterious to the development of the offspring. This study focused on the social behavior of offspring exposed to seizures in utero. A pilocarpine model of temporal lobe epilepsy was induced in female Wistar rats that were mated after the first spontaneous seizure. Early after birth, pups from an epileptic mother were reared by a control mother. To evaluate the influence of the adoption process, two other groups were added: rat pups from control mothers cross-fostered with other control mothers, and rat pups reared by their birth mother. Animals exposed to seizures in utero showed impaired social behavior with no signs of anxiety-like behavior. This study demonstrated that epileptic seizures during pregnancy could be harmful to brain development and may increase the risk of developing neurodevelopmental disorders. The mechanisms underlying the abnormalities of social behavior are not well understood, and further studies in this field are warranted.
authors.affiliation: Programa de Pós-graduação em Distúrbios do Desenvolvimento, Laboratório de Neurobiologia, Universidade Presbiteriana Mackenzie, Rua da Consolação, 930. Prédio 38, CEP 01302-907 São Paulo, Brazil.
authors.forename: Gisane Faria
authors.initials: GF
authors.lastname: Novaes
authors.forename: Debora
authors.initials: D
authors.lastname: Amado
authors.forename: Fulvio Alexandre
authors.initials: FA
authors.lastname: Scorza
authors.forename: Roberta Monterazzo
authors.initials: RM
authors.lastname: Cysneiros
mesh_terms: D000818:Animals; D001007:Anxiety / Q000523:psychology; D003292:Convulsants; D004830:Epilepsy, Tonic-Clonic / Q000523:psychology; D005260:Female; D008297:Male; D010862:Pilocarpine; D011247:Pregnancy; D011248:Pregnancy Complications / Q000139:chemically induced / Q000523:psychology*; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced / Q000523:psychology*; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced / Q000523:psychology*; D012919:Social Behavior
chemical_list: D003292:Convulsants; D010862:Pilocarpine