title: Emerging concepts of laser-activated nanoparticles for tissue bonding.
abstract: We report recent achievements and future perspectives of minimally invasive bonding of biological tissues triggered by laser light. In particular, we review new advancements in the biomedical exploitation of near-infrared absorbing gold nanoparticles as an original solution for the photothermal closure of surgical incisions. Advanced concepts of laser tissue bonding involving the application of hybrid nanocomposites obtained by inclusion of nanochromophores into biopolymer scaffolds are also introduced. The perspectives of tissue bonding are discussed in the following aspects: (1) tissue bonding with highly-stabilized nanochromophores, (2) enhanced tissue bonding with patterned nanocomposites, (3) real-time monitoring of temperature distributions, (4) tracking of tissue regeneration based on the optical resonances of gold nanoparticles.
authors.affiliation: Institute of Applied Physics Nello Carrara, Italian National Research Council, via Madonna del Piano, 10-50019 Sesto Fiorentino, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Matteini
authors.forename: Fulvio
authors.initials: F
authors.lastname: Ratto
authors.forename: Francesca
authors.initials: F
authors.lastname: Rossi
authors.forename: Roberto
authors.initials: R
authors.lastname: Pini
mesh_terms: D000818:Animals; D003198:Computer Simulation; D006046:Gold; D048091:Guided Tissue Regeneration; D006979:Hyperthermia, Induced; D007208:Indocyanine Green; D053685:Laser Therapy; D053768:Metal Nanoparticles; D053761:Nanocomposites; D061088:Photoacoustic Techniques; D011817:Rabbits; D013696:Temperature; D054457:Tissue Scaffolds; D041623:Tomography, Optical Coherence
chemical_list: D006046:Gold; D007208:Indocyanine Green