title: Cinnamic acid as one of the antidiabetic active principle(s) from the seeds of Syzygium alternifolium.
abstract: The Indian traditional system of medicine prescribed plant therapies for diseases including diabetes mellitus. One such plant is Syzygium alternifolium (SA). We reported earlier, that fraction C from aqueous extract of SA seeds showed good antihyperglycemic and antihyperlipidemic activities. In continuation to it, we have performed bioassay guided fractionation of fraction C and identified cinnamic acid as a component with antihyperglycemic activity. A detailed study was undertaken to elucidate its mode of antidiabetic action by giving fraction C (50 mg/kgb.w) orally, once a day for 30 days in STZ induced diabetic rats. The altered enzyme activities of carbohydrate metabolism in liver and kidney of diabetic rats were significantly (p<0.01) reverted to near normal levels by the administration of fraction C. Fraction C lowered blood glucose as expected, immediately following treatment, and led to glibenclamide-like modulatory effects on enzyme activities related to glucose homeostasis after 30 days treatment, indicating that cinnamic acid may prove useful in diabetes management.
authors.affiliation: Department of Biochemistry, Sri Venkateswara University, Tirupati 517502, AP, India.
authors.forename: Ramesh Babu
authors.initials: RB
authors.lastname: Kasetti
authors.forename: Shaik Abdul
authors.initials: SA
authors.lastname: Nabi
authors.forename: Sirasangandla
authors.initials: S
authors.lastname: Swapna
authors.forename: Chippada
authors.initials: C
authors.lastname: Apparao
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002853:Chromatography, Liquid; D002934:Cinnamates / Q000494:pharmacology*; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008297:Male; D013058:Mass Spectrometry; D051381:Rats; D017208:Rats, Wistar; D012639:Seeds / Q000737:chemistry*; D027842:Syzygium / Q000196:embryology*
chemical_list: D001786:Blood Glucose; D002934:Cinnamates; D007004:Hypoglycemic Agents; C029010:cinnamic acid