title: In vitro controlled release of an anti-inflammatory from daily disposable therapeutic contact lenses under physiological ocular tear flow.
abstract: Novel molecularly imprinted, therapeutic contact lenses capable of controlled release of the non-steroidal anti-inflammatory (NSAID) diclofenac sodium were synthesized, exploiting ionic non-covalent interactions. Poly(HEMA-co-DEAEM-co-PEG200DMA) soft contact lenses were prepared (105±5 μm thickness, diameter 15.0±0.2mm, base curve of 8.6±0.2mm) with different monomer to template ratios and dynamic release studies were conducted in artificial lacrimal solution using two different in vitro methods. Under infinite sink conditions, imprinted contact lenses demonstrated concentration dependent release kinetics. Under physiological flow rates, by increasing the M/T ratio from 1 to 10.5, the release rate decreased from 11.72 μg/h to 6.75 μg/h during the first 48 h. The release rate was more constant, moving toward zero-order release. To use these lenses as daily disposable lenses, the first 24h of release was studied and found to be linear with a rate of 17.27, 11.99, and 8.74 μg/h for M/T ratios of 1, 3.5, and 10.5, respectively. Furthermore, the lenses prepared with a M/T ratio of 10.5 released diclofenac at a rate close to the maximum dose delivered by commercial eye drops, making them ideal for use as daily disposable lenses, and potentially leading to better patient benefit with substantially increased efficacy.
authors.affiliation: Biomimetic and Biohybrid Materials, Biomedical Devices, and Drug Delivery Laboratories, Department of Chemical Engineering, Auburn University, Auburn, AL 36849, USA.
authors.forename: Arianna
authors.initials: A
authors.lastname: Tieppo
authors.forename: Kayla M
authors.initials: KM
authors.lastname: Pate
authors.forename: Mark E
authors.initials: ME
authors.lastname: Byrne
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D003261:Contact Lenses; D003692:Delayed-Action Preparations; D004008:Diclofenac / Q000008:administration & dosage*; D004209:Disposable Equipment; D007700:Kinetics; D008689:Methacrylates / Q000737:chemistry; D054802:Molecular Imprinting; D009883:Ophthalmic Solutions; D011092:Polyethylene Glycols / Q000737:chemistry; D013666:Tears / Q000378:metabolism; D013997:Time Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003692:Delayed-Action Preparations; D008689:Methacrylates; D009883:Ophthalmic Solutions; C421283:poly(ethylene glycol)-dimethacrylate; D004008:Diclofenac; D011092:Polyethylene Glycols; C005044:hydroxyethyl methacrylate; C519537:diethylaminoethyl methacrylate