title: Tamoxifen keratopathy as seen with in-vivo confocal microscopy.
abstract: Tamoxifen is a triphenylethylene non-steroidal oestrogen antagonist widely used in oestrogen receptor-positive breast cancer, with well-documented ocular side-effects. Here we report a corneal confocal microscopy finding of a patient on low-dose tamoxifen.   We believe that this is the first case report of a patient on low-dose tamoxifen with demonstrable corneal stromal crystalline deposits with confocal microscopy, but clinically asymptomatic with unremarkable corneal findings on cursory slit lamp examination.   In summary, confocal microscopy is a useful adjunct in monitoring tamoxifen crystalline keratopathy, and helps detect subclinical deposits not visible/detected on slit lamp examination.
authors.affiliation: Tennent Institute of Ophthalmology, Gartnavel General Hospital, Glasgow, UK.
authors.forename: Sonali
authors.initials: S
authors.lastname: Tarafdar
authors.forename: Lik Thai
authors.initials: LT
authors.lastname: Lim
authors.forename: Cian E
authors.initials: CE
authors.lastname: Collins
authors.forename: Kanna
authors.initials: K
authors.lastname: Ramaesh
mesh_terms: D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage / Q000009:adverse effects*; D003316:Corneal Diseases / Q000139:chemically induced*; D003319:Corneal Stroma / Q000473:pathology; D003460:Crystallization; D005260:Female; D006801:Humans; D018613:Microscopy, Confocal; D013629:Tamoxifen / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D018931:Antineoplastic Agents, Hormonal; D013629:Tamoxifen