title: The first total synthesis of (+)-mucosin.
abstract: The first total synthesis of (+)-mucosin has been completed allowing assignment of the absolute stereochemistry of the natural product. A zirconium induced co-cyclisation was utilised to install the correct stereochemistry of the four contiguous stereocentres around the unusual bicyclo[4.3.0]nonene core.
authors.affiliation: Chemistry, University of Southampton, Southampton, Hampshire SO17 1BJ, UK.
authors.forename: Alan R
authors.initials: AR
authors.lastname: Henderson
authors.forename: Jozef
authors.initials: J
authors.lastname: Stec
authors.forename: David R
authors.initials: DR
authors.lastname: Owen
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Whitby
mesh_terms: D000818:Animals; D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis* / Q000737:chemistry; D015777:Eicosanoids / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D009942:Organometallic Compounds / Q000737:chemistry; D011161:Porifera; D013237:Stereoisomerism; D015040:Zirconium / Q000737:chemistry
chemical_list: D001688:Biological Products; D019086:Bridged Bicyclo Compounds, Heterocyclic; D015777:Eicosanoids; D009942:Organometallic Compounds; C573270:mucosin; D015040:Zirconium