title: A novel phytotoxic nonenolide from Phomopsis sp. HCCB03520.
abstract: A novel phytotoxic nonenolide, (6S,7R,9R)-6,7-dihydroxy-9-propylnon-4-eno-9-lactone (1), was isolated from solid cultures of the endophytic fungus Phomopsis sp. HCCB03520, together with three known compounds, cytochalasin H (2), cytochalasin N (3), and epoxycytochalasin H (4). The structures of these compounds were elucidated through spectroscopic analysis, and the absolute configurations were determined by CD spectroscopy. Phytotoxic activities of compounds 1-4 were also investigated. Compound 1 showed phytotoxic activity on germination and radicle growth of Medicago sativa, Trifolium hybridum, and Buchloe dactyloides.
authors.affiliation: Shanghai Institute of Pharmaceutical Industry, Shanghai 200040, PR China.
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Yang
authors.forename: Mei
authors.initials: M
authors.lastname: Ge
authors.forename: Yu
authors.initials: Y
authors.lastname: Yin
authors.forename: Yi
authors.initials: Y
authors.lastname: Chen
authors.forename: Minyu
authors.initials: M
authors.lastname: Luo
authors.forename: Daijie
authors.initials: D
authors.lastname: Chen
mesh_terms: D001203:Ascomycota / Q000737:chemistry*; D018525:Germination / Q000187:drug effects*; D006573:Heterocyclic Compounds, 1-Ring / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D000455:Medicago sativa / Q000187:drug effects* / Q000254:growth & development; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry / Q000187:drug effects; D006109:Poaceae / Q000187:drug effects* / Q000254:growth & development; D012639:Seeds / Q000737:chemistry / Q000187:drug effects; D029921:Trifolium / Q000187:drug effects* / Q000254:growth & development
chemical_list: C572908:6,7-dihydroxy-9-propylnon-4-eno-9-lactone; D006573:Heterocyclic Compounds, 1-Ring; D007783:Lactones