title: [Why chlorthalidone, the thiazide antihypertensive of choice, is neglected?].
abstract: Diuretics, particularly thiazides and thiazide-like drugs, are antihypertensives of first choice. A prominent role in this group is reserved to chlorthalidone because of several pharmacological (e.g. longer biological half-life) and clinical advantages (e.g. superior reduction in cardiovascular events). Nevertheless, favored is hydrochlorothiazide, especially in fixed drug combinations, revealing a poor policy.
authors.affiliation: Medicinski fakultet Sveucilista u Splitu. zvonko.rumboldt@mefst.hr
authors.forename: Zvonko
authors.initials: Z
authors.lastname: Rumboldt
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002752:Chlorthalidone / Q000627:therapeutic use*; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use*; D006973:Hypertension / Q000188:drug therapy*; D049993:Sodium Chloride Symporter Inhibitors / Q000627:therapeutic use
chemical_list: D000959:Antihypertensive Agents; D049993:Sodium Chloride Symporter Inhibitors; D006852:Hydrochlorothiazide; D002752:Chlorthalidone