title: [Distributional characteristics of apolipoprotein A5 Gene c.553G > T polymorphism and association with serum triglyceride in healthy Chinese Han and Uighur people].
abstract: OBJECTIVE
  To explore the distribution characteristics of apolipoprotein A5 (ApoA5) gene c.553G > T polymorphism and the relationship of serum lipid in Chinese Han and Uighur populations in Xinjiang, China.
  
  
  METHODS
  The genotypes of ApoA5 gene c.553G > T polymorphism were detected in 406 Uighur and 527 Han people by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP).
  
  
  RESULTS
  The frequencies of GG, GT and TT genotypes of ApoA5 gene c.553G > T were 378 (93.1%), 27 (6.7%) and 1 (0.25%) patients in Uighurs versus 478 (90.7%) patients, 49 (9.3%) patients and 0% in Hans. There was no significant difference in the distribution of genotypes between two groups (P > 0.05). In both groups, individuals with T allele (TT + GT genotype) had a higher level of serum triglyceride than those with GG genotype. After adjusting for gender, age, smoking, alcoholism, body mass index, blood pressure and blood lipid, non-conditional logistic regression analyses revealed that individuals with T allele (TT + GT genotype) in both groups had an elevated risk of HTG versus the GG genotype (OR = 3.31, 95%CI: 1.31 - 8.36 in Uighurs vs OR = 3.98, 95%CI: 1.81 - 8.74 in Hans).
  
  
  CONCLUSIONS
  The mutation of c.553G > T polymorphism of ApoA5 gene is associated with the level of serum triglyceride in Uighur and Han populations of Xinjiang. And T allele may be a risk factor of hypertriglyceridemia.
authors.affiliation: Department of Coronary Artery Disease, Heart Center, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China.
authors.forename: Anniwaer
authors.initials: A
authors.lastname: Abulizi
authors.forename: Shan
authors.initials: S
authors.lastname: Yuan
authors.forename: Yi-tong
authors.initials: YT
authors.lastname: Ma
authors.forename: Xiang
authors.initials: X
authors.lastname: Xie
authors.forename: Yi-ning
authors.initials: YN
authors.lastname: Yang
authors.forename: Zhen-yan
authors.initials: ZY
authors.lastname: Fu
authors.forename: Xiang
authors.initials: X
authors.lastname: Ma
authors.forename: Xiao-mei
authors.initials: XM
authors.lastname: Li
authors.forename: Fen
authors.initials: F
authors.lastname: Liu
authors.forename: Bang-dang
authors.initials: BD
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D000072040:Apolipoprotein A-V; D001054:Apolipoproteins A / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D002681:China; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D014280:Triglycerides / Q000097:blood*
chemical_list: C437704:APOA5 protein, human; D000072040:Apolipoprotein A-V; D001054:Apolipoproteins A; D014280:Triglycerides