title: The surgical significance of residual mucosal abnormalities in rectal cancer following neoadjuvant chemoradiotherapy.
abstract: BACKGROUND
  Local excision of rectal cancer after neoadjuvant chemoradiotherapy (CRT) has been proposed as an alternative to radical surgery in selected patients. However, little is known about the significance of the morphological and histological features of residual tumour.
  
  
  METHODS
  Patients who had undergone CRT at the authors' institution between 1997 and 2010 were identified. Multiple features were assessed as putative markers of pathological response. These included: gross residual disease, diameter of residual mucosal abnormalities, tumour differentiation, presence of lymphovascular/perineural invasion and lymph node ratio.
  
  
  RESULTS
  Data from 220 of 276 patients were suitable for analysis. Diameter of residual mucosal abnormalities correlated strongly with pathological tumour category after CRT (ypT) (P < 0·001). Forty of 42 tumours downstaged to ypT0/1 had residual mucosal abnormalities of 2·99 cm or less after CRT. Importantly, 19 of 31 patients with a complete pathological response had evidence of a residual mucosal abnormality consistent with an incomplete clinical response. The ypT category was associated with both pathological node status after CRT (P < 0·001) and lymph node ratio (P < 0·001). Positive nodes were found in only one of 42 patients downstaged to ypT0/1. The risk of nodal metastases was associated with poor differentiation (P = 0·027) and lymphovascular invasion (P < 0·001).
  
  
  CONCLUSIONS
  In this series, the majority of patients with a complete pathological response did not have a complete clinical response. In tumours downstaged to ypT0/1 after CRT, residual mucosal abnormalities were predominantly small and had a 2 per cent risk of positive nodes, thus potentially facilitating transanal excision. The presence of adverse histological characteristics risk stratified tumours for nodal metastases.
authors.affiliation: Section of Surgery and Surgical Specialties, University College Dublin, Ireland. fassiefern@hotmail.com
authors.forename: F M
authors.initials: FM
authors.lastname: Smith
authors.forename: K H
authors.initials: KH
authors.lastname: Chang
authors.forename: K
authors.initials: K
authors.lastname: Sheahan
authors.forename: J
authors.initials: J
authors.lastname: Hyland
authors.forename: P R
authors.initials: PR
authors.lastname: O'Connell
authors.forename: D C
authors.initials: DC
authors.lastname: Winter
mesh_terms: D000368:Aged; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D059248:Chemoradiotherapy / Q000379:methods*; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009361:Neoplasm Invasiveness; D018365:Neoplasm, Residual; D011446:Prospective Studies; D012004:Rectal Neoplasms / Q000473:pathology / Q000628:therapy*; D012007:Rectum / Q000601:surgery; D012307:Risk Factors; D047368:Tumor Burden