title: Fragment-based design of small RNA binders: promising developments and contribution of NMR.
abstract: Fragment-based drug design has become increasingly popular over the last decade. We review here the use of this approach to design small RNA binders. In addition, we discuss the use of NMR to detect the binding of small molecules on RNA targets and to guide chemists in the design of compounds targeting RNA.
authors.affiliation: CNRS, UMR 8638, Synthèse et structure de molécules d'intérêt pharmacologique, 4 avenue de l'Observatoire, 75006 Paris, France.
authors.forename: Roba
authors.initials: R
authors.lastname: Moumné
authors.forename: Marjorie
authors.initials: M
authors.lastname: Catala
authors.forename: Valéry
authors.initials: V
authors.lastname: Larue
authors.forename: Laurent
authors.initials: L
authors.lastname: Micouin
authors.forename: Carine
authors.initials: C
authors.lastname: Tisné
mesh_terms: D015195:Drug Design; D006801:Humans; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D012313:RNA / Q000378:metabolism*; D054852:Small Molecule Libraries / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D008024:Ligands; D054852:Small Molecule Libraries; D012313:RNA