title: Stuck between a scalpel and a rock, or molecular pathology and legal-ethical issues in use of tissues for clinical care and research: what must a pathologist know?
abstract: Personalized medicine and health care reform offer the opportunity for pathologists to have a more central and visible role in patient care. Pathologists face new and more complicated requests for clinical and research testing on tissue specimens, including testing for somatic and inherited mutations. Pathologists must comprehend the applications and requirements for molecular testing and their legal and ethical responsibilities in handling tissue requests for clinical and research purposes to best serve the needs of patients and clinicians and to comply with federal and state laws. This article reviews these rapidly evolving and complex areas.
authors.affiliation: Department of Pathology and Laboratory Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA.
authors.forename: Sarah
authors.initials: S
authors.lastname: Dry
authors.forename: Wayne W
authors.initials: WW
authors.lastname: Grody
authors.forename: Paul
authors.initials: P
authors.lastname: Papagni
mesh_terms: D018070:Biological Specimen Banks / Q000941:ethics / Q000331:legislation & jurisprudence; D035843:Biomedical Research / Q000941:ethics / Q000331:legislation & jurisprudence / Q000379:methods; D032962:Consent Forms / Q000331:legislation & jurisprudence; D004992:Ethics, Medical; D006801:Humans; D025202:Molecular Diagnostic Techniques; D010340:Pathology, Surgical / Q000941:ethics / Q000331:legislation & jurisprudence / Q000379:methods; D013048:Specimen Handling / Q000941:ethics