title: Merging domino and redox chemistry: stereoselective access to di- and trisubstituted β,γ-unsaturated acids and esters.
abstract: Merging is the game! The coupling of a domino reaction and an internal neutral redox reaction constitutes an excellent manifold for the stereoselective synthesis of di- and trisubstituted olefins featuring a malonate unit, an ester, or a free carboxylic acid as substituents at the allylic position (see scheme; MW=microwave). The reaction utilizes simple starting materials (propargyl vinyl ethers), methanol or water as solvents, and a very simple and bench-friendly protocol.
authors.affiliation: Departamento de Química Biológica y Biotecnología, Instituto de Productos Naturales y Agrobiología, Consejo Superior de Investigaciones Científicas, Astrofísico Francisco Sánchez 3, 38206 La Laguna, Tenerife, Spain. dtejedor@ipna.csic.es
authors.forename: David
authors.initials: D
authors.lastname: Tejedor
authors.forename: Gabriela
authors.initials: G
authors.lastname: Méndez-Abt
authors.forename: Leandro
authors.initials: L
authors.lastname: Cotos
authors.forename: Fernando
authors.initials: F
authors.lastname: García-Tellado
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D004952:Esters; D008872:Microwaves; D015394:Molecular Structure; D010084:Oxidation-Reduction; D012997:Solvents / Q000737:chemistry; D013237:Stereoisomerism; D014867:Water / Q000737:chemistry
chemical_list: D000475:Alkenes; D002264:Carboxylic Acids; D004952:Esters; D012997:Solvents; D014867:Water