title: Impact of human adenovirus type 3 dodecahedron on host cells and its potential role in viral infection.
abstract: During human adenovirus type 3 (Ad3) infection, an excess of penton base and fiber proteins are produced which form dodecahedral particles composed of 12 pentamers of penton base and 12 trimers of fiber protein. No biological functions have yet been ascribed to Ad3 dodecahedra. Here, we show that dodecahedra compete with Ad3 virions for binding to the cell surface and trigger cell remodeling, giving new insights into possible biological functions of dodecahedra in the Ad3 infectious cycle.
authors.affiliation: CNRS, Unit of Virus Host Cell Interaction, Grenoble, France. pfender@embl.fr
authors.forename: Pascal
authors.initials: P
authors.lastname: Fender
authors.forename: Kathryn
authors.initials: K
authors.lastname: Hall
authors.forename: Guy
authors.initials: G
authors.lastname: Schoehn
authors.forename: G Eric
authors.initials: GE
authors.lastname: Blair
mesh_terms: D000260:Adenoviruses, Human / Q000502:physiology*; D036022:Capsid Proteins / Q000378:metabolism*; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism; D051301:Desmoglein 2 / Q000378:metabolism; D054884:Host-Pathogen Interactions; D006801:Humans; D011485:Protein Binding; D053585:Virus Attachment
chemical_list: D036022:Capsid Proteins; D051301:Desmoglein 2; C018315:hexon capsid protein, Adenovirus; C043322:penton protein, adenovirus