title: Myocardial infarction in a newborn heterozygous for the MTHFR C677T mutation.
abstract: Neonatal myocardial infarction secondary to congenital heart disease, anomalous coronary artery anatomy, thromboembolism, coagulopathy, birth asphyxia, and unknown causes has been previously reported. We now report an infant who suffered a massive myocardial infarction during birth, requiring extensive resuscitation and aggressive management. A thrombus, the origin of which was not detected on autopsy, was found occluding the proximal left coronary artery several hours after birth. Genetic studies revealed a single copy variant of the MTHFR C677T mutation that we speculate may have predisposed the infant to coronary thrombosis.
authors.affiliation: Naval Hospital Oak Harbor, Whidbey Island, WA, USA. amy.clark2@med.navy.mil
authors.forename: Amy B
authors.initials: AB
authors.lastname: Clark
authors.forename: Theophil A
authors.initials: TA
authors.lastname: Stokes
authors.forename: Henry F
authors.initials: HF
authors.lastname: Krous
authors.forename: Douglas N
authors.initials: DN
authors.lastname: Carbine
mesh_terms: D003328:Coronary Thrombosis / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D009154:Mutation; D009203:Myocardial Infarction / Q000235:genetics*
chemical_list: C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)