title: [HPV infection might play a role in the development of non-melanoma skin cancer in immunocompetent individuals].
abstract: Human papillomavirus (HPV) is necessary for the development of cervical cancer and is also involved in vulvar, anus, penis and head and neck cancer. Little is known about the role of HPV infection in non-melanoma skin cancer (NMSC). Through a systematic review of the literature, we studied the HPV prevalence in immunocompetent individuals in relation to NMSC. We found that HPV, including multiple HPV types, tended to be more prevalent in NMSC, especially in squamous cell carcinoma (SCC) compared to basal cell carcinoma and healthy skin, indicating a potential link between HPV and SCC in immunocompetent individuals.
authors.affiliation: Afdeling for Virus, Hormoner og Kræft, Institut for Epidemiologisk Kræftforskning, Kræftens Bekæmpelse, Strandboulevarden 49, 2100 København Ø, Denmark.
authors.forename: Fatima
authors.initials: F
authors.lastname: Birch-Johansen
authors.forename: Bodil
authors.initials: B
authors.lastname: Norrild
authors.forename: Anne Braae
authors.initials: AB
authors.lastname: Olesen
authors.forename: Allan
authors.initials: A
authors.lastname: Jensen
authors.forename: Susanne Krüger
authors.initials: SK
authors.lastname: Kjær
mesh_terms: D000914:Antibodies, Viral / Q000032:analysis; D002280:Basal Cell Carcinoma / Q000821:virology; D002294:Carcinoma, Squamous Cell / Q000821:virology; D004279:DNA, Viral / Q000235:genetics; D006801:Humans; D007121:Immunocompetence; D027383:Papillomaviridae / Q000235:genetics / Q000276:immunology; D030361:Papillomavirus Infections / Q000150:complications / Q000821:virology*; D012307:Risk Factors; D012878:Skin Neoplasms / Q000209:etiology / Q000821:virology*
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral