title: Combined fruit and vegetable intake is correlated with improved inflammatory and oxidant status from a cross-sectional study in a community setting.
abstract: Previous studies have examined the relationship between specific nutrient and food intakes with limited markers of either inflammation or oxidant status. The objective of this study was to determine if an increase in combined self-reported fruit and vegetable (F&V) intake in a community setting was associated with improved multiple markers of inflammatory and oxidant status. A community group (N = 1000, age 18-85 years, 61% female) gave two fasted blood samples separated by 12 weeks. Blood inflammatory biomarkers included total leukocytes (WBC), plasma C-reactive protein (CRP), interleukin-6 (IL-6), IL-10, tumor necrosis factor-alpha (TNF-α), monocyte chemoattractant protein-1, and granulocyte colony stimulating factor. Measured oxidant status markers were ferric reducing ability of plasma (FRAP), oxygen radical absorbance capacity (ORAC) and plasma F₂-isoprostanes. The relation of markers across categories of F&V intake was examined. In analyses controlling for other important dietary and lifestyle factors, IL-6 and TNF-α were significantly lower across categories of increasing F&V intakes (p < 0.008). FRAP and ORAC were significantly higher (p < 0.0001 and p = 0.047 respectively) while F(2)-isoprostanes was significantly lower (p < 0.0001) across F&V categories. In a community study, several markers of both inflammation and oxidant status were associated in a putatively salutary direction by higher intake of combined F&V, supporting current guidelines suggesting increased F&V consumption for the prevention of chronic diseases.
authors.affiliation: Department of Nutrition and Health Care Management, Appalachian State University, ASU Box 32168, Boone, NC 28608, USA. rootmm@appstate.edu
authors.forename: Martin M
authors.initials: MM
authors.lastname: Root
authors.forename: Megan C
authors.initials: MC
authors.lastname: McGinn
authors.forename: David C
authors.initials: DC
authors.lastname: Nieman
authors.forename: Dru A
authors.initials: DA
authors.lastname: Henson
authors.forename: Serena A
authors.initials: SA
authors.lastname: Heinz
authors.forename: R Andrew
authors.initials: RA
authors.lastname: Shanely
authors.forename: Amy M
authors.initials: AM
authors.lastname: Knab
authors.forename: Fuxia
authors.initials: F
authors.lastname: Jin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D003430:Cross-Sectional Studies; D004032:Diet / Q000706:statistics & numerical data*; D028441:F2-Isoprostanes / Q000097:blood*; D005260:Female; D005638:Fruit; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D016877:Oxidants / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*; D014675:Vegetables; D055815:Young Adult
chemical_list: D015415:Biomarkers; D028441:F2-Isoprostanes; D015850:Interleukin-6; D016877:Oxidants; D014409:Tumor Necrosis Factor-alpha