title: Chemoprevention of pancreatic cancer-one step closer.
abstract: BACKGROUND
  Since for pancreatic cancer the mortality rate approaches the incidence rate with only 1-4% of all patients surviving 5 years, it would be would be of great value to provide chemopreventive treatment for high-risk individuals.
  
  
  CONCLUSIONS
  The preclinical study of pancreatic intraepithelial neoplasia (PanINs) has recently been made possible by the generation of genetically modified animal models, which recapitulate human PanINs and invasive pancreatic cancer on a genetic and histomorphologic level. Very recently, several groups have reported first evidence of chemoprevention of pancreatic cancer.
authors.affiliation: Department of Surgery, Philipps University Marburg, Baldingerstrasse, 35043 Marburg, Germany. fendrich@med.uni-marburg.de
authors.forename: Volker
authors.initials: V
authors.lastname: Fendrich
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D035843:Biomedical Research; D002278:Carcinoma in Situ / Q000235:genetics / Q000401:mortality / Q000517:prevention & control*; D021441:Carcinoma, Pancreatic Ductal / Q000235:genetics / Q000401:mortality / Q000517:prevention & control*; D045744:Cell Line, Tumor; D002471:Cell Transformation, Neoplastic / Q000187:drug effects / Q000235:genetics / Q000473:pathology; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D009361:Neoplasm Invasiveness; D009368:Neoplasm Transplantation; D010190:Pancreatic Neoplasms / Q000235:genetics / Q000401:mortality / Q000517:prevention & control*; D012307:Risk Factors; D015996:Survival Rate
chemical_list: D000970:Antineoplastic Agents