title: Tripartilactam, a cyclobutane-bearing tricyclic lactam from a Streptomyces sp. in a dung beetle's brood ball.
abstract: Tripartilactam, a structurally unprecedented cyclobutane-bearing tricyclic lactam metabolite, was discovered from Streptomyces sp. isolated from a brood ball of the dung beetle, Copris tripartitus. The structure of this compound was elucidated by the combination of NMR, MS, UV, and IR spectroscopy and multistep chemical derivatization. Tripartilactam was evaluated as a Na(+)/K(+) ATPase inhibitor (IC(50) = 16.6 μg/mL).
authors.affiliation: Natural Products Research Institute, College of Pharmacy, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 151-742, Republic of Korea.
authors.forename: Seon-Hui
authors.initials: SH
authors.lastname: Park
authors.forename: Kyuho
authors.initials: K
authors.lastname: Moon
authors.forename: Hea-Son
authors.initials: HS
authors.lastname: Bang
authors.forename: Seong-Hwan
authors.initials: SH
authors.lastname: Kim
authors.forename: Dong-Gyu
authors.initials: DG
authors.lastname: Kim
authors.forename: Ki-Bong
authors.initials: KB
authors.lastname: Oh
authors.forename: Jongheon
authors.initials: J
authors.lastname: Shin
authors.forename: Dong-Chan
authors.initials: DC
authors.lastname: Oh
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D001517:Coleoptera / Q000382:microbiology*; D003503:Cyclobutanes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D005243:Feces / Q000382:microbiology*; D006801:Humans; D007769:Lactams / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D049994:Sodium Potassium Chloride Symporter Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D013302:Streptomyces / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D003503:Cyclobutanes; D007769:Lactams; D049994:Sodium Potassium Chloride Symporter Inhibitors; C572276:tripartilactam