title: Abnormal default-mode network in angiotensin converting enzyme D allele carriers with remitted geriatric depression.
abstract: Using a cross-sectional case-control study of remitted geriatric depression (RGD), we characterised the relationships among cognitive function, whole-brain functional connectivity of the posterior cingulate cortex (PCC), and the angiotensin-converting enzyme (ACE) insertion or deletion (I/D) polymorphism during resting state. A total of 26 RGD patients and 24 matched controls were recruited, and neuropsychological tests, functional magnetic resonance imaging (fMRI) and ACE I/D genotype were examined for each subject. A 2 × 2 factorial analysis of variance (ANOVA) model (presence/absence of depression and presence/absence of ACE-D) was used to detect the interaction effect. Subsequent analyses were restricted to the significant interaction regions. There were significant interactions between disease and genotype at two clusters: left superior temporal gyrus/middle temporal gyrus and left cerebellum. And the ACE I/D polymorphism has disease-specific effects on the left superior temporal gyrus/middle temporal gyrus and cerebellum crus I. Furthermore, there was a significant positive correlation between the functional connection of PCC-left cerebellum crus I and the CFT-delayed recall test scores (r=0.668, P=0.003) in RGD group ACE-D allele carriers. These results suggest that the ACE I/D polymorphism can modulate the pathology of RGD, and the status of geriatric depression and the ACE-D allele may synergistically induce altered resting state network activity, which could influence the cognitive function and increase the mortality risk for cognitive impairment.
authors.affiliation: Department of Neuropsychiatry, Affiliated ZhongDa Hospital and Institute of Neuropsychiatry of Southeast University, Nanjing 210009, China.
authors.forename: Zan
authors.initials: Z
authors.lastname: Wang
authors.forename: Yonggui
authors.initials: Y
authors.lastname: Yuan
authors.forename: Feng
authors.initials: F
authors.lastname: Bai
authors.forename: Jiayong
authors.initials: J
authors.lastname: You
authors.forename: Lingjiang
authors.initials: L
authors.lastname: Li
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000150:complications* / Q000235:genetics* / Q000503:physiopathology; D003430:Cross-Sectional Studies; D003866:Depressive Disorder / Q000150:complications* / Q000235:genetics* / Q000503:physiopathology; D005260:Female; D059907:Functional Neuroimaging; D005838:Genotype; D006179:Gyrus Cinguli / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D007703:Peptidyl-Dipeptidase A