title: Polymorphisms in the gene that encodes the iron transport protein ferroportin 1 influence susceptibility to tuberculosis.
abstract: BACKGROUND
  We studied the association between iron intake and polymorphisms in the iron transporter gene SLC40A1 and the risk of tuberculosis.
  
  
  METHODS
  We compared iron intake, the frequency of SLC40A1 mutations, and interactions among these variables among 98 tuberculosis patients and 125 controls in Kwazulu-Natal, South Africa.
  
  
  RESULTS
  Four SLC40A1 single-nucleotide polymorphisms (SNPs) were associated with an increased risk of tuberculosis and 1 SNP with reduced risk. We also found a gene-environment interaction for 4 nonexonic SNPs and iron intake.
  
  
  CONCLUSIONS
  This pilot study demonstrated an association between polymorphisms in SLC40A1 and tuberculosis and provided evidence of an interaction between dietary iron and SLC40A1.
authors.affiliation: Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
authors.forename: Meghan A
authors.initials: MA
authors.lastname: Baker
authors.forename: Douglas
authors.initials: D
authors.lastname: Wilson
authors.forename: Kristina
authors.initials: K
authors.lastname: Wallengren
authors.forename: Andreas
authors.initials: A
authors.lastname: Sandgren
authors.forename: Oleg
authors.initials: O
authors.lastname: Iartchouk
authors.forename: Nisha
authors.initials: N
authors.lastname: Broodie
authors.forename: Sunali D
authors.initials: SD
authors.lastname: Goonesekera
authors.forename: Pardis C
authors.initials: PC
authors.lastname: Sabeti
authors.forename: Megan B
authors.initials: MB
authors.lastname: Murray
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D027682:Cation Transport Proteins / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D013019:South Africa; D014376:Tuberculosis / Q000235:genetics*; D000098742:Ferroportin
chemical_list: D027682:Cation Transport Proteins; D000098742:Ferroportin