title: [Massive fundic gland polyposis caused by chronic proton pump inhibitor therapy].
abstract: We report two cases of a massive fundic gland polyposis associated with protracted proton pump inhibitor (PPI) therapy. Both patients were females aged 51. On repeated endoscopy, the number of fundic gland polyps was increasing steeply, and they resulted in a passage disorder. In the first case, the enormous number of polyps made endoscopic removal impossible, so the patient was treated by total gastrectomy. Although our case is the second one reported in the world, we would like to draw the attention to this rare complication of long lasting PPI therapy.
authors.affiliation: Pécsi Tudományegyetem, Általános Orvostudományi Kar Patológia Intézet. ivett.hegedus@kk.pte.hu
authors.forename: Ivett
authors.initials: I
authors.lastname: Hegedus
authors.forename: Csaba
authors.initials: C
authors.lastname: Csizmadia
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Lomb
authors.forename: László
authors.initials: L
authors.lastname: Cseke
authors.forename: Yadamsuren
authors.initials: Y
authors.lastname: Enkh-Amar
authors.forename: László
authors.initials: L
authors.lastname: Pajor
authors.forename: Barna
authors.initials: B
authors.lastname: Bogner
mesh_terms: D005260:Female; D005743:Gastrectomy; D005748:Gastric Fundus / Q000187:drug effects / Q000473:pathology* / Q000601:surgery; D005772:Gastrointestinal Transit; D006801:Humans; D008875:Middle Aged; D011127:Polyps / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery*; D054328:Proton Pump Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D013272:Stomach Diseases / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery*
chemical_list: D054328:Proton Pump Inhibitors