title: A look at uterine wound healing through a histopathological study of uterine scars.
abstract: BACKGROUND
  Few histopathologic studies of uterine wound healing have been published compared with similar healing in other tissues. Our objective was to examine the histopathology resulting from iatrogenic trauma to the myometrium to acquire a better understanding of possible aberrations in uterine wound healing.
  
  
  METHODS
  We studied paired injured myometrium and uninvolved myometrium from 7 hysterectomy specimens. All subjects had either abnormal bleeding or chronic pain following an iatrogenic injury to the myometrium. The time between the initial injury and hysterectomy ranged from 2 months to 13 years. Tissue was evaluated with hematoxylin and eosin (H&E) followed by Masson Trichrome staining for collagen, Weigert-Van Gieson elastic staining, and/or Kreyberg staining for fibrin and glycosaminoglycans or MIB-1 (Ki-67) immunhistochemistry for cell proliferation.
  
  
  RESULTS
  Histopathologic examination of the 7 paired tissues revealed evidence of altered healing including myofiber disarray, elastosis, tissue edema, and inflammation. Small fibroids, myometrial hyperplasia, a keloid-like region of scar and adenomyosis were also observed.
  
  
  CONCLUSIONS
  Myofiber disarray and elastosis may be markers of aberrancy in wound healing after iatrogenic uterine trauma. Altered myometrial scarring in these cases may have contributed to the clinical outcome necessitating hysterectomies. Myometrial hyperplasia in the region of the scars might also contribute to the clinical presentation as well. Small fibroids found within scars and evidence of a keloid-like structure may also represent alterations in uterine wound healing.
authors.affiliation: University of California-San Diego, San Diego, CA, USA.
authors.forename: Hilary A
authors.initials: HA
authors.lastname: Roeder
authors.forename: Stewart F
authors.initials: SF
authors.lastname: Cramer
authors.forename: Phyllis C
authors.initials: PC
authors.lastname: Leppert
mesh_terms: D000328:Adult; D002921:Cicatrix / Q000473:pathology*; D005260:Female; D006801:Humans; D006965:Hyperplasia; D007044:Hysterectomy; D007049:Iatrogenic Disease; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis; D008875:Middle Aged; D009215:Myometrium / Q000293:injuries; D014599:Uterus / Q000473:pathology*; D014945:Wound Healing
chemical_list: D019394:Ki-67 Antigen