title: GSTO and AS3MT genetic polymorphisms and differences in urinary arsenic concentrations among residents in Bangladesh.
abstract: We determined whether single nucleotide polymorphisms (SNPs) in the glutathione S-transferase omega (GSTO) and arsenic(III)methyltransferase (AS3MT) genes were associated with concentrations of urinary arsenic metabolites among 900 individuals without skin lesions in Bangladesh. Four SNPs were assessed in these genes. A pathway analysis evaluated the association between urinary arsenic metabolites and SNPs. GSTO1 rs4925 homozygous wild type was significantly associated with higher monomethylarsonic acid (MMA) and dimethylarsinic acid urinary concentrations, whereas wild-type AS3MT rs11191439 had significantly lower levels of As(III) and MMA. Genetic polymorphisms GSTO and As3MT modify arsenic metabolism as evidenced by altered urinary arsenic excretion.
authors.affiliation: Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA. emarod@hsph.harvard.edu
authors.forename: Ema G
authors.initials: EG
authors.lastname: Rodrigues
authors.forename: Molly
authors.initials: M
authors.lastname: Kile
authors.forename: Elaine
authors.initials: E
authors.lastname: Hoffman
authors.forename: Quazi
authors.initials: Q
authors.lastname: Quamruzzaman
authors.forename: Mahmuder
authors.initials: M
authors.lastname: Rahman
authors.forename: Golam
authors.initials: G
authors.lastname: Mahiuddin
authors.forename: Yumei
authors.initials: Y
authors.lastname: Hsueh
authors.forename: David C
authors.initials: DC
authors.lastname: Christiani
mesh_terms: D000328:Adult; D001151:Arsenic / Q000652:urine*; D001459:Bangladesh; D005260:Female; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008297:Male; D008780:Methyltransferases / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: D008780:Methyltransferases; C505756:AS3MT protein, human; D005982:Glutathione Transferase; D001151:Arsenic