title: Adenocarcinoma metastatic to the uterine cervix: a case series.
abstract: OBJECTIVE
  The objectives of this report are, first, to describe the clinical behavior of cases of carcinoma metastatic to the uterine cervix treated at our institution in order to carry out a systematic review to establish the behavioral patterns of the most frequent metastases to the cervix and, second, to generate guidelines for their diagnosis and treatment.
  
  
  METHODS
  At the National Institute of Cancer of Mexico (INCan), we performed a review of the clinical files with a diagnosis of malignant neoplasm metastatic to the uterine cervix between 1990 and 2009. For a systematic review, we conducted a PubMed search between the years 1970 and 2009 of case reports and series of cases of patients with metastatic gastric, breast, ovarian and colorectal cancer. We analyzed each report individually and extracted the patients' clinical data from our cases and reports, including the primary tumor, cervical metastases and survival rates.
  
  
  RESULTS
  There were 10 cases of tumors metastatic to the uterine cervix. Metastasis was documented in one-half of the patients during follow up, with two of these cases having the cervix as the only site. We included the following reports in the systematic review: 13 reports of gastric-associated cancer, 30 related to breast cancer, nine with ovarian-associated cancer and 10 related to colorectal cancer.
  
  
  CONCLUSIONS
  Metastatic cervical activity is an infrequent event. The prognosis of survival is poor in the presence of gastric or ovarian cancer and cervical metastases.
authors.affiliation: Department of Pathology, National Institute of Cancer of Mexico, Mexico City, Mexico.
authors.forename: Delia
authors.initials: D
authors.lastname: Pérez-Montiel
authors.forename: Alberto
authors.initials: A
authors.lastname: Serrano-Olvera
authors.forename: Luz Calderón
authors.initials: LC
authors.lastname: Salazar
authors.forename: Lucely
authors.initials: L
authors.lastname: Cetina-Pérez
authors.forename: Myrna
authors.initials: M
authors.lastname: Candelaria
authors.forename: Jaime
authors.initials: J
authors.lastname: Coronel
authors.forename: Luis Alonso Herrera
authors.initials: LA
authors.lastname: Montalvo
authors.forename: David Cantú
authors.initials: DC
authors.lastname: de León
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000401:mortality / Q000556:secondary*; D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000473:pathology; D015179:Colorectal Neoplasms / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000473:pathology; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000473:pathology; D016019:Survival Analysis; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000556:secondary*