title: Autoimmune features caused by dengue fever: a case report.
abstract: Dengue virus is the most important mosquito-borne viral disease in the world. Co-circulation of the four types of dengue viruses and expansion of dengue epidemic gave rise to infection enhancement and a big expansion of clinical aspects of the disease. Herein we report a case of a 25-year-old white woman with dengue fever and numerous associated autoimmune features. Our patient had proteinuria, an extensive right pleural effusion, a thin pericardial effusion and ascites. She had a low C3 level and positive antinuclear antibody; cryoglobulins were also positive. The numerous autoimmune features of this patient were a diagnostic challenge, since she was a young woman and could be easily mistaken for a rheumatologic patient in a newly open disease. Dengue infection probably was a triggering event causing an abnormal immune response. Therefore, dengue should be suspected in patients with hematological disorders and autoimmune features in endemic regions or those who have travelled to those regions.
authors.affiliation: Department of Internal Medicine, Universidade Estadual de Campinas, Campinas, SP, Brazil. jardimde@gmail.com
authors.forename: Denis Leonardo Fontes
authors.initials: DL
authors.lastname: Jardim
authors.forename: Daniela Miti Lemos
authors.initials: DM
authors.lastname: Tsukumo
authors.forename: Rodrigo N
authors.initials: RN
authors.lastname: Angerami
authors.forename: Marco Antonio de
authors.initials: MA
authors.lastname: Carvalho Filho
authors.forename: Mário José Abdalla
authors.initials: MJ
authors.lastname: Saad
mesh_terms: D000328:Adult; D001327:Autoimmune Diseases / Q000276:immunology* / Q000821:virology; D003715:Dengue / Q000175:diagnosis / Q000276:immunology*; D005260:Female; D006801:Humans