title: How host heterogeneity governs tuberculosis reinfection?
abstract: Recurrent episodes of tuberculosis (TB) can be due to relapse of latent infection or exogenous reinfection, and discrimination is crucial for control planning. Molecular genotyping of Mycobacterium tuberculosis isolates offers concrete opportunities to measure the relative contribution of reinfection in recurrent disease. Here, a mathematical model of TB transmission is fitted to data from 14 molecular epidemiology studies, enabling the estimation of relevant epidemiological parameters. Meta-analysis reveals that rates of reinfection after successful treatment are higher than rates of new TB, raising an important question about the underlying mechanism. We formulate two alternative mechanisms within our model framework: (i) infection increases susceptibility to reinfection or (ii) infection affects individuals differentially, thereby recruiting high-risk individuals to the group at risk for reinfection. The second mechanism is better supported by the fittings to the data, suggesting that reinfection rates are inflated through a population phenomenon that occurs in the presence of heterogeneity in individual risk of infection. As a result, rates of reinfection are higher when measured at the population level even though they might be lower at the individual level. Finally, differential host recruitment is modulated by transmission intensity, being less pronounced when incidence is high.
authors.affiliation: Instituto Gulbenkian de Ciência, Apartado 14, 2781-901 Oeiras, Portugal. ggomes@igc.gulbenkian.pt
authors.forename: M Gabriela M
authors.initials: MG
authors.lastname: Gomes
authors.forename: Ricardo
authors.initials: R
authors.lastname: Aguas
authors.forename: João S
authors.initials: JS
authors.lastname: Lopes
authors.forename: Marta C
authors.initials: MC
authors.lastname: Nunes
authors.forename: Carlota
authors.initials: C
authors.lastname: Rebelo
authors.forename: Paula
authors.initials: P
authors.lastname: Rodrigues
authors.forename: Claudio J
authors.initials: CJ
authors.lastname: Struchiner
mesh_terms: D004198:Disease Susceptibility / Q000453:epidemiology*; D005838:Genotype; D006801:Humans; D015994:Incidence; D008954:Models, Biological; D009169:Mycobacterium tuberculosis / Q000235:genetics*; D055502:Secondary Prevention; D014376:Tuberculosis / Q000453:epidemiology* / Q000382:microbiology / Q000517:prevention & control* / Q000635:transmission*