title: Results of salvage abdominoperineal resection after failed chemoradiation therapy for epidermoid anal canal carcinoma: Retrospective analysis at a single institution.
abstract: OBJECTIVE
  The standard therapeutic approach to epidermoid anal canal cancer consists of combined radiation therapy and chemotherapy. Although disease control has been reported to have excellent results, as many as 40% of patients will develop locoregional disease progression. The treatment of choice for patients with persistent (PD) or recurrent disease (RD) is salvage abdominoperineal resection (APR). The purpose of this study was to review our experience with salvage surgery in this group of patients.
  
  
  METHODS
  The medical records of all patients with epidermoid anal canal cancer treated from 1997 to 2010 in our department were retrospectively reviewed. Nine patients who presented with persistent or locally recurrent anal canal cancer were subjected to salvage APR. Before surgery, all of the patients had received chemoradiation therapy (CRT).
  
  
  RESULTS
  There were 9 patients (7 women, 2 men) with a median age of 59 years (range 40-79). Six patients underwent radical salvage APR for persistent disease and 3 patients for recurrent disease. There were no deaths attributable to operation. The median follow-up time was 31.75 months (range 3-108) after salvage surgery. Two patients died of disease progression, with a median survival time of 24 months (range 12-36). At the time of last follow-up, 6 patients were alive without evidence of recurrent disease, and one patient was lost to follow-up. The median follow-up time for survivors was 34.3 months (range 3-108).
  
  
  CONCLUSIONS
  Long-term survival can be achieved in the majority of patients who undergo radical salvage APR after failed CRT for epidermoid carcinoma of the anal canal.
authors.affiliation: 2nd Department of Surgery, Aretaieion Hospital, University of Athens, Greece.
authors.forename: I
authors.initials: I
authors.lastname: Papaconstantinou
authors.forename: A
authors.initials: A
authors.lastname: Yiallourou
authors.forename: T
authors.initials: T
authors.lastname: Theodosopoulos
authors.forename: L
authors.initials: L
authors.lastname: Samanides
authors.forename: V
authors.initials: V
authors.lastname: Smyrniotis
authors.forename: A
authors.initials: A
authors.lastname: Fotopoulos
authors.forename: G
authors.initials: G
authors.lastname: Polymeneas
authors.forename: C
authors.initials: C
authors.lastname: Gennatas
authors.forename: D
authors.initials: D
authors.lastname: Voros
mesh_terms: D000005:Abdomen / Q000473:pathology / Q000601:surgery; D000328:Adult; D000368:Aged; D001005:Anus Neoplasms / Q000532:radiotherapy / Q000601:surgery* / Q000628:therapy; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy / Q000601:surgery* / Q000628:therapy; D059248:Chemoradiotherapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010502:Perineum / Q000473:pathology / Q000601:surgery; D012189:Retrospective Studies; D016879:Salvage Therapy / Q000379:methods*; D015996:Survival Rate; D017211:Treatment Failure