title: Effect of magnetic fields on tumor growth and viability.
abstract: Breast cancer is the most common nonskin cancer and is the second leading cause of cancer-related deaths in women. Most methods of intervention involve combinations of surgery, chemotherapy, and ionizing radiation. Both chemotherapy and ionizing radiation can be effective against many  types of cancer, but they also harm normal tissues. The use of nonionizing, magnetic fields has shown early promise in a number of in vitro and animal studies. Our study tested the effect of varying durations of magnetic exposure on tumor growth and viability in mice injected with breast cancer  cells. Cancer cells were labeled through stable expression of firefly luciferase for monitoring of tumor growth and progression by using an in vivo imaging system. We hypothesized that magnetic field exposure would influence tumor growth and progression. Our results showed that exposure of  the mice to magnetic fields for 360 min daily for as long as 4 wk suppressed tumor growth. Our study is unique in that it uses an in vivo imaging system to monitor the growth and progression of tumors in real time in individual mice. Our findings support further exploration of the potential  of magnetic fields in cancer therapeutics, either as adjunct or primary therapy.
authors.affiliation: Comparative Medicine Program, Department of Pathology, School of Medicine, University of Maryland, Baltimore, Maryland, USA.
authors.forename: Ivan
authors.initials: I
authors.lastname: Tatarov
authors.forename: Aruna
authors.initials: A
authors.lastname: Panda
authors.forename: Daniel
authors.initials: D
authors.lastname: Petkov
authors.forename: Krishnan
authors.initials: K
authors.lastname: Kolappaswamy
authors.forename: Keyata
authors.initials: K
authors.lastname: Thompson
authors.forename: Anoop
authors.initials: A
authors.lastname: Kavirayani
authors.forename: Michael M
authors.initials: MM
authors.lastname: Lipsky
authors.forename: Edward
authors.initials: E
authors.lastname: Elson
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Davis
authors.forename: Stuart S
authors.initials: SS
authors.lastname: Martin
authors.forename: Louis J
authors.initials: LJ
authors.lastname: DeTolla
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001943:Breast Neoplasms / Q000473:pathology / Q000628:therapy*; D005260:Female; D006652:Histological Techniques; D020287:In Situ Nick-End Labeling; D008156:Luciferases; D055909:Magnetic Field Therapy / Q000379:methods*; D051379:Mice; D013997:Time Factors
chemical_list: D008156:Luciferases