title: The direct catalytic asymmetric aldol reaction of α-substituted nitroacetates with aqueous formaldehyde under base-free neutral phase-transfer conditions.
abstract: Enantioselective direct aldol reaction of α-substituted nitroacetates with aqueous formaldehyde for the synthesis of α-alkyl serines has been achieved under base-free neutral phase-transfer conditions with a bifunctional chiral phase-transfer catalyst.
authors.affiliation: Laboratory of Synthetic Organic Chemistry, Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto 606-8502, Japan.
authors.forename: Seiji
authors.initials: S
authors.lastname: Shirakawa
authors.forename: Kensuke
authors.initials: K
authors.lastname: Ota
authors.forename: Shogo J
authors.initials: SJ
authors.lastname: Terao
authors.forename: Keiji
authors.initials: K
authors.lastname: Maruoka