title: Chemokine-dependent B cell-T cell interactions in chronic lymphocytic leukemia and multiple myeloma - targets for therapeutic intervention?
abstract: BACKGROUND
  Chemokines and their receptors play essential roles in the development, maintenance and proper functioning of the immune system. B cell-T cell interactions are modulated by chemokines. In B cell malignancies, these interactions may have tumor-promoting consequences.
  
  
  METHODS
  This review summarizes physiological B cell-T cell interactions and discusses their pathological role in the onset and progression of B cell malignancies with a special focus on chronic lymphocytic leukemia and multiple myeloma. Experimental data on chemokine-guided B cell-T cell actions in B cell malignancies from murine models as well as in vitro data are summarized and their potential as future therapeutic targets is critically discussed.
  
  
  CONCLUSIONS
  Direct or indirect targeting of chemokine receptors involved in localization and T-cell-dependent activation of B lymphocytes can provide strong synergisms with conventional or immunomodulatory therapies by disrupting the microenvironmental conditions necessary for survival and proliferation of malignant B lymphocytes. However, further knowledge of these interactions between B and T cells is needed.
authors.affiliation: Tyrolean Cancer Research Institute, Innsbruck, Austria. Karin.Joehrer@tkfi.at
authors.forename: Karin
authors.initials: K
authors.lastname: Jöhrer
authors.forename: Sebastian W
authors.initials: SW
authors.lastname: Hofbauer
authors.forename: Claudia
authors.initials: C
authors.lastname: Zelle-Rieser
authors.forename: Richard
authors.initials: R
authors.lastname: Greil
authors.forename: Tanja N
authors.initials: TN
authors.lastname: Hartmann
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000378:metabolism* / Q000473:pathology; D002450:Cell Communication; D018925:Chemokines / Q000378:metabolism*; D006801:Humans; D056747:Immunomodulation; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D008213:Lymphocyte Activation; D051379:Mice; D009101:Multiple Myeloma / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D019707:Receptors, Chemokine / Q000378:metabolism; D013601:T-Lymphocytes / Q000378:metabolism* / Q000473:pathology
chemical_list: D018925:Chemokines; D019707:Receptors, Chemokine