title: Cuprizone inhibits demyelinating leukomyelitis by reducing immune responses without virus exacerbation in an infectious model of multiple sclerosis.
abstract: Multiple sclerosis is one of the most common demyelinating central nervous system diseases in young adults. Theiler's murine encephalomyelitis (TME) is a widely used virus-induced murine model for human myelin disorders. Immunosuppressive approaches generally reduce antiviral immunity and therefore increase virus dissemination with clinical worsening. In the present study, the progressive course of TME was significantly delayed due to a five-week cuprizone feeding period. Cuprizone was able to minimize demyelinating leukomyelitis without virus exacerbation. This phenomenon is supposed to be a consequence of selective inhibition of detrimental inflammatory responses with maintained protective immunity against the virus.
authors.affiliation: Department of Pathology, University of Veterinary Medicine Hannover, Bünteweg 17, D-30559 Hannover, Germany.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Herder
authors.forename: Florian
authors.initials: F
authors.lastname: Hansmann
authors.forename: Martin
authors.initials: M
authors.lastname: Stangel
authors.forename: Dirk
authors.initials: D
authors.lastname: Schaudien
authors.forename: Karl
authors.initials: K
authors.lastname: Rohn
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Baumgärtner
authors.forename: Andreas
authors.initials: A
authors.lastname: Beineke
mesh_terms: D000818:Animals; D002614:Chelating Agents / Q000627:therapeutic use*; D003471:Cuprizone / Q000627:therapeutic use*; D016207:Cytokines / Q000097:blood / Q000276:immunology; D004195:Disease Models, Animal; D005260:Female; D051379:Mice; D009103:Multiple Sclerosis / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology / Q000821:virology; D017945:Theilovirus / Q000187:drug effects* / Q000276:immunology
chemical_list: D002614:Chelating Agents; D016207:Cytokines; D003471:Cuprizone