title: Glucoregulatory function in adult rhesus macaques (Macaca mulatta) undergoing treatment with medroxyprogesterone acetate for endometriosis.
abstract: Endometriosis affects a large percentage of the rhesus macaques (Macaca mulatta) at our institution. When the disease is diagnosed in macaques on long-term research protocols, the treatment of choice in our facility is monthly administration of medroxyprogesterone acetate (MPA)  to decrease estrogen release and subsequently diminish clinical signs associated with the disease. Because hormonal fluctuations associated with the normal menstrual cycle are known to affect parameters of glucoregulatory function in rhesus macaques, we evaluated the effect of MPA treatment  on glucoregulatory function cross-sectionally in 6 animals and longitudinally in 4 animals with endometriosis. Our hypothesis was that monthly administration of MPA for the treatment of endometriosis would negatively affect glucoregulatory function in rhesus macaques. We found that adult female  rhesus macaques on MPA therapy for 1.4 to 36.1 mo had lower insulin sensitivity than did age- and weight-matched healthy control animals. In addition, glucoregulatory function was reduced after MPA treatment as compared with pretreatment levels in a group of 4 macaques. These data suggest  that glucoregulatory function should be considered when endometriosis treatment is planned for rhesus macaques.
authors.affiliation: Wisconsin National Primate Research Center, University of Wisconsin-Madison, WI, USA. ccruzen@primate.wisc.edu
authors.forename: Christina L
authors.initials: CL
authors.lastname: Cruzen
authors.forename: Scott T
authors.initials: ST
authors.lastname: Baum
authors.forename: Ricki J
authors.initials: RJ
authors.lastname: Colman
mesh_terms: D000818:Animals; D000830:Animals, Laboratory; D001786:Blood Glucose / Q000378:metabolism*; D003430:Cross-Sectional Studies; D004715:Endometriosis / Q000188:drug therapy / Q000662:veterinary*; D005260:Female; D007333:Insulin Resistance / Q000502:physiology; D008137:Longitudinal Studies; D008253:Macaca mulatta; D017258:Medroxyprogesterone Acetate / Q000627:therapeutic use*; D008992:Monkey Diseases / Q000188:drug therapy* / Q000378:metabolism*; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D017258:Medroxyprogesterone Acetate