title: The clinical relevance of the clopidogrel-proton pump inhibitor interaction.
abstract: Proton pump inhibitors are often prescribed concomitantly with clopidogrel and aspirin to patients post-percutaneous coronary interventions and/or an acute coronary syndrome to mitigate the risk of potential gastrointestinal bleeding, associated primarily with clopidogrel use. Over the last several years, there have been data both supporting and refuting a clopidogrel-proton pump inhibitor interaction. This review critically considers the current evidence and provides practical recommendations to healthcare providers.
authors.affiliation: VA North Texas Health Care System, Dallas, TX 75216, USA.
authors.forename: Atif
authors.initials: A
authors.lastname: Mohammad
authors.forename: Emmanouil S
authors.initials: ES
authors.lastname: Brilakis
authors.forename: Rick A
authors.initials: RA
authors.lastname: Weideman
authors.forename: Bertis B
authors.initials: BB
authors.lastname: Little
authors.forename: Subhash
authors.initials: S
authors.lastname: Banerjee
mesh_terms: D000818:Animals; D001711:Biotransformation / Q000235:genetics; D000077144:Clopidogrel; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics / Q000378:metabolism; D004347:Drug Interactions; D019317:Evidence-Based Medicine; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced / Q000517:prevention & control*; D005838:Genotype; D006801:Humans; D010641:Phenotype; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D011110:Polymorphism, Genetic; D017410:Practice Guidelines as Topic; D054328:Proton Pump Inhibitors / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D018570:Risk Assessment; D012307:Risk Factors; D013988:Ticlopidine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use
chemical_list: D010975:Platelet Aggregation Inhibitors; D054328:Proton Pump Inhibitors; D003577:Cytochrome P-450 Enzyme System; D000077144:Clopidogrel; D013988:Ticlopidine