title: Hyperprolactinemia with aripiprazole: understanding the paradox.
abstract: Aripiprazole, due to its partial agonist activity at the D2 receptors, is often recommended as the drug of choice in patients who develop antipsychotic-induced hyperprolactinemia. We report a case of a female patient who developed hyperprolactinemia while on treatment with aripiprazole. This partial D2 agonistic activity of aripiprazole could be dose related, and hence, at higher doses, aripiprazole by itself can have dopamine antagonistic properties and hence cause prolactin system abnormalities.
authors.affiliation: 1The Metabolic Clinic in Psychiatry, Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore, India; and 2Department of Psychiatry, Kasturba Medical College, Manipal University, Manipal, India.
authors.forename: Gayatri
authors.initials: G
authors.lastname: Saraf
authors.forename: Rishikesh V
authors.initials: RV
authors.lastname: Behere
authors.forename: Ganesan
authors.initials: G
authors.lastname: Venkatasubramanian
authors.forename: Naren P
authors.initials: NP
authors.lastname: Rao
authors.forename: Shivarama
authors.initials: S
authors.lastname: Varambally
authors.forename: B N
authors.initials: BN
authors.lastname: Gangadhar
mesh_terms: D000293:Adolescent; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology; D000068180:Aripiprazole; D018491:Dopamine Agonists / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D018492:Dopamine Antagonists / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000139:chemically induced*; D010879:Piperazines / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology; D015363:Quinolones / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology; D017448:Receptors, Dopamine D2 / Q000187:drug effects / Q000378:metabolism
chemical_list: D014150:Antipsychotic Agents; D018491:Dopamine Agonists; D018492:Dopamine Antagonists; D010879:Piperazines; D015363:Quinolones; D017448:Receptors, Dopamine D2; D000068180:Aripiprazole