title: Cardiac catheterization within 1 to 3 days of proximal aortic surgery is not associated with increased postoperative acute kidney injury.
abstract: OBJECTIVE
  Cardiac catheterization shortly before coronary artery bypass grafting or valve surgery has been associated with increased postoperative acute kidney injury. The relationship between catheterization timing and acute kidney injury after proximal aortic surgery remains unknown.
  
  
  METHODS
  Between August 2005 and February 2011, a total of 285 consecutive patients underwent cardiac catheterization before elective proximal aortic surgery with cardiopulmonary bypass at a single institution. The association between timing of catheterization and postoperative acute kidney injury (defined as postoperative increase in serum creatinine ≥ 50% of baseline) was assessed using logistic regression analysis.
  
  
  RESULTS
  Of 285 patients, 152 (53%) underwent catheterization on preoperative days 1 to 3 and 133 (47%) underwent catheterization on preoperative day 4 or before. Acute kidney injury occurred in 88 (31%) patients, 3 (1.1%) requiring dialysis. Acute kidney injury occurred in 37 (24%) patients catheterized on preoperative days 1 to 3, and 51 (38%) patients catheterized on preoperative day 4 or before. Catheterization on preoperative days 1 to 3 was not associated with an increased risk of acute kidney injury relative to catheterization on preoperative day 4 or before (unadjusted odds ratio, 0.52; 95% confidence interval, 0.31-0.86; P = .01; adjusted odds ratio, 0.35; 95% confidence interval, 0.17-0.73; P = .005).
  
  
  CONCLUSIONS
  Cardiac catheterization within 1 to 3 days of elective proximal aortic surgery appears safe and should be considered acceptable practice for patients at low risk of acute kidney injury.
authors.affiliation: Division of Thoracic and Cardiovascular Surgery, Duke University Medical Center, Durham, NC 27710, USA
authors.forename: Nicholas D
authors.initials: ND
authors.lastname: Andersen
authors.forename: Judson B
authors.initials: JB
authors.lastname: Williams
authors.forename: Emil L
authors.initials: EL
authors.lastname: Fosbol
authors.forename: Asad A
authors.initials: AA
authors.lastname: Shah
authors.forename: Syamal D
authors.initials: SD
authors.lastname: Bhattacharya
authors.forename: Rajendra H
authors.initials: RH
authors.lastname: Mehta
authors.forename: G Chad
authors.initials: GC
authors.lastname: Hughes
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood / Q000209:etiology*; D000368:Aged; D001013:Aorta, Thoracic / Q000601:surgery*; D015415:Biomarkers / Q000097:blood; D006328:Cardiac Catheterization / Q000009:adverse effects*; D002315:Cardiopulmonary Bypass / Q000009:adverse effects; D016009:Chi-Square Distribution; D003287:Contrast Media / Q000009:adverse effects; D017023:Coronary Angiography / Q000009:adverse effects*; D003404:Creatinine / Q000097:blood; D017558:Elective Surgical Procedures; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009657:North Carolina; D016017:Odds Ratio; D012042:Registries; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D015854:Up-Regulation; D014656:Vascular Surgical Procedures / Q000009:adverse effects*
chemical_list: D015415:Biomarkers; D003287:Contrast Media; D003404:Creatinine