title: New pentahydroxylated steroids from the South China Sea gorgonian Subergorgia suberosa.
abstract: Two new pentahydroxylated steroids, (3β,12β,16β,23E)-cholesta-5,23-diene-3,12,16,20,25-pentaol (1) and (3β,12β,16β)-cholesta-5,25(26)-diene-3,12,16,20,24-pentaol (2), were isolated from the EtOH extract of the South China Sea gorgonian Subergorgia suberosa. In addition, four known steroids were detected. The structures of these compounds were established by spectroscopic methods and comparison of their data with those of the related known compounds. In addition, the cyctotoxicities of the compounds were evaluated against selected cancer cell lines.
authors.affiliation: Department of Chemistry, Jinan University, Guangzhou 510632, PR China.
authors.forename: Xiao-Jian
authors.initials: XJ
authors.lastname: Liao
authors.forename: Li-Dan
authors.initials: LD
authors.lastname: Tang
authors.forename: Yuan-Wei
authors.initials: YW
authors.lastname: Liang
authors.forename: Shui-Lian
authors.initials: SL
authors.lastname: Jian
authors.forename: Shi-Hai
authors.initials: SH
authors.lastname: Xu
authors.forename: Yong-Hong
authors.initials: YH
authors.lastname: Liu
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002681:China; D000431:Ethanol / Q000737:chemistry; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009792:Oceans and Seas; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D013256:Steroids; D000431:Ethanol