title: Influence of healing time on the ultrasonic response of the bone-implant interface.
abstract: The aim of the present study is to investigate the effect of bone healing on the ultrasonic response of coin-shaped titanium implants inserted in rabbit tibiae. The ultrasound response of the interface was measured in vitro at 15 MHz after 7 and 13 weeks of healing time. The average value of the ratio r between the amplitudes of the echo of the bone-implant interface and of the water-implant interface was determined. The bone-implant contact (BIC) was measured by histomorphometry and the degree of mineralisation of bone was estimated qualitatively by histologic staining. The significant decrease of the ultrasonic quantitative indicator r (p = 2.10⁻⁴) vs. healing time (from r = 0.53 to r = 0.49) is explained by (1) the increase of the BIC (from 27% to 69%) and (2) the increase of mineralization of newly formed bone tissue, both phenomena inducing a decrease of the gap of acoustical impedance.
authors.affiliation: CNRS, Université Paris 7, Laboratoire de Biomécanique Biomatériaux Ostéo-Articulaires, UMR CNRS 7052, Paris, France. guillaume.haiat@univ-paris-est.fr
authors.forename: Vincent
authors.initials: V
authors.lastname: Mathieu
authors.forename: Romain
authors.initials: R
authors.lastname: Vayron
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Soffer
authors.forename: Fani
authors.initials: F
authors.lastname: Anagnostou
authors.forename: Guillaume
authors.initials: G
authors.lastname: Haïat
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001696:Biomechanical Phenomena; D004867:Equipment Design; D005260:Female; D010012:Osteogenesis; D019736:Prostheses and Implants; D011474:Prosthesis Design; D011817:Rabbits; D015203:Reproducibility of Results; D012815:Signal Processing, Computer-Assisted; D014025:Titanium; D014159:Transducers; D014464:Ultrasonic Therapy / Q000295:instrumentation*; D014945:Wound Healing / Q000502:physiology*
chemical_list: D014025:Titanium