title: Targeted radiotherapy for malignant gliomas.
abstract: Malignant glioma remains a disease with poor prognosis despite recent advances in the multidisciplinary care of this disease. Herein we review the evolution of and recent advances in radiation therapy for malignant glioma that have allowed for more targeted therapy, potentially improving efficacy while decreasing normal tissue toxicity. Current and emerging techniques are presented, including stereotactic radiotherapy and radiosurgery, brachytherapy, radioimmunotherapy, and charged particle therapy, as well as the combination of these modalities with novel targeted biochemotherapies.
authors.affiliation: Duke University Medical Center, DUMC, Durham, NC 27710, USA.
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Oh
authors.forename: David C
authors.initials: DC
authors.lastname: Adamson
authors.forename: John P
authors.initials: JP
authors.lastname: Kirkpatrick
mesh_terms: D001932:Brain Neoplasms / Q000188:drug therapy / Q000532:radiotherapy* / Q000601:surgery; D003131:Combined Modality Therapy; D019583:Dose Fractionation, Radiation; D005909:Glioblastoma / Q000188:drug therapy / Q000532:radiotherapy* / Q000601:surgery; D006801:Humans; D016634:Radiosurgery