title: Access to skipped polyene macrolides through ring-closing metathesis: total synthesis of the RNA polymerase inhibitor ripostatin B.
abstract: Rip-Roaring! A convergent total synthesis of antibiotic ripostatin B was developed. A key step in the synthesis is a metathesis reaction allowing for a ring closure to the labile doubly skipped triene macrolide.
authors.affiliation: TU Dortmund University, Faculty of Chemistry, Germany.
authors.forename: Philipp
authors.initials: P
authors.lastname: Winter
authors.forename: Wolf
authors.initials: W
authors.lastname: Hiller
authors.forename: Mathias
authors.initials: M
authors.lastname: Christmann
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D012321:DNA-Directed RNA Polymerases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018942:Macrolides / Q000737:chemistry*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D011090:Polyenes / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D004791:Enzyme Inhibitors; D007783:Lactones; D018942:Macrolides; D011090:Polyenes; C096601:ripostatin B; D012321:DNA-Directed RNA Polymerases