title: Acute therapy with intravenous omeprazole on caustic esophageal injury: a prospective case series.
abstract: The ingestion of caustic substances may result in significant esophageal injury. There is no standard treatment protocol for esophageal injury and most patients are treated with a proton pump inhibitor or H2 antagonist. However, there is no clinical study evaluating the efficacy of omeprazole for caustic esophageal injury. A prospective study of 13 adult patients (>18 years of age) who were admitted to our hospital for caustic ingestion between May 2010 and June 2010 was conducted. Mucosal damage was graded using a modified endoscopic classification described by Zargar et al. Patients were treated with a proton pump inhibitor and maintained without oral intake until their condition was considered stable. Patients received omeprazole 80 mg in bolus IV, followed by continuous infusion of 8 mg/hour for 72 hours. A control endoscopy was performed 72 hours after admission. There was significant difference regarding endoscopic healing between the before and after omeprazole infusion (P = 0.004). There was no hospital mortality at the follow-up. Omeprazole may effectively be used in the acute phase treatment of caustic esophagus injuries.
authors.affiliation: Department of Gastroenterology, Ankara Education and Research Hospital, Ankara, Turkey.
authors.forename: B
authors.initials: B
authors.lastname: Cakal
authors.forename: E
authors.initials: E
authors.lastname: Akbal
authors.forename: S
authors.initials: S
authors.lastname: Köklü
authors.forename: A
authors.initials: A
authors.lastname: Babalı
authors.forename: E
authors.initials: E
authors.lastname: Koçak
authors.forename: A
authors.initials: A
authors.lastname: Taş
mesh_terms: D000328:Adult; D002057:Burns, Chemical / Q000188:drug therapy* / Q000473:pathology; D002424:Caustics / Q000506:poisoning*; D015331:Cohort Studies; D004638:Emergency Treatment / Q000379:methods; D004935:Esophageal Diseases / Q000139:chemically induced* / Q000188:drug therapy*; D004945:Esophagoscopy / Q000379:methods; D004947:Esophagus / Q000187:drug effects / Q000293:injuries; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000187:drug effects / Q000473:pathology; D009853:Omeprazole / Q000008:administration & dosage*; D011446:Prospective Studies; D054328:Proton Pump Inhibitors / Q000008:administration & dosage*; D018570:Risk Assessment; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D002424:Caustics; D054328:Proton Pump Inhibitors; D009853:Omeprazole