title: IQGAP1: a regulator of intracellular spacetime relativity.
abstract: Activating and inhibiting receptors of lymphocytes collect valuable information about their mikròs kósmos. This information is essential to initiate or to turn off complex signaling pathways. Irrespective of these advances, our knowledge on how these intracellular activation cascades are coordinated in a spatiotemporal manner is far from complete. Among multiple explanations, the scaffolding proteins have emerged as a critical piece of this evolutionary tangram. Among many, IQGAP1 is one of the essential scaffolding proteins that coordinate multiple signaling pathways. IQGAP1 possesses multiple protein interaction motifs to achieve its scaffolding functions. Using these domains, IQGAP1 has been shown to regulate a number of essential cellular events. This includes actin polymerization, tubulin multimerization, microtubule organizing center formation, calcium/calmodulin signaling, Pak/Raf/Mek1/2-mediated Erk1/2 activation, formation of maestrosome, E-cadherin, and CD44-mediated signaling and glycogen synthase kinase-3/adenomatous polyposis coli-mediated β-catenin activation. In this review, we summarize the recent developments and exciting new findings of cellular functions of IQGAP1.
authors.affiliation: Laboratory of Molecular Immunology and Immunotherapy, Blood Research Institute, Milwaukee, WI 53226, USA. subra.malar@bcw.edu
authors.forename: Subramaniam
authors.initials: S
authors.lastname: Malarkannan
authors.forename: Aradhana
authors.initials: A
authors.lastname: Awasthi
authors.forename: Kamalakannan
authors.initials: K
authors.lastname: Rajasekaran
authors.forename: Pawan
authors.initials: P
authors.lastname: Kumar
authors.forename: Kristina M
authors.initials: KM
authors.lastname: Schuldt
authors.forename: Allison
authors.initials: A
authors.lastname: Bartoszek
authors.forename: Niranjan
authors.initials: N
authors.lastname: Manoharan
authors.forename: Nicholas K
authors.initials: NK
authors.lastname: Goldner
authors.forename: Colleen M
authors.initials: CM
authors.lastname: Umhoefer
authors.forename: Monica S
authors.initials: MS
authors.lastname: Thakar
mesh_terms: D000818:Animals; D002450:Cell Communication / Q000276:immunology*; D002478:Cells, Cultured; D042541:Intracellular Space / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism*; D016131:Lymphocyte Subsets / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D025941:Protein Interaction Mapping / Q000379:methods; D055503:Protein Multimerization / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology; D020703:ras GTPase-Activating Proteins / Q000737:chemistry / Q000172:deficiency / Q000502:physiology*
chemical_list: C101203:IQ motif containing GTPase activating protein 1; D020703:ras GTPase-Activating Proteins