title: [Analgesic effects of cannabinoids on central pain syndrome].
abstract: It was shown that cannabinoids anandamide, HU210 and WIN 55,212-2 inhibit both spontaneous episodes of pain and mechanical allodynia in rats with central pain syndrome caused by disturbance of inhibitory processes in the dorsal horns of lumbar spinal cord. The analgesic effect is most pronounced in the intrathecal route of administration. The intensity of analgesic actions of cannabinoids on the central pain syndrome in rats, depending on the drug is as follows: HU210 > WIN 55,212-2 > anandamide.
authors.forename: S I
authors.initials: SI
authors.lastname: Igon'kina
authors.forename: M V
authors.initials: MV
authors.lastname: Churiukanov
authors.forename: V V
authors.initials: VV
authors.lastname: Churiukanov
authors.forename: M L
authors.initials: ML
authors.lastname: Kukushkin
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D001416:Back Pain / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology*; D002186:Cannabinoids / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006930:Hyperalgesia / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D008161:Lumbosacral Region / Q000473:pathology / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D013116:Spinal Cord / Q000473:pathology / Q000503:physiopathology*
chemical_list: D018712:Analgesics, Non-Narcotic; D002186:Cannabinoids