title: Efficacy of trans-cinnamaldehyde against Psoroptes cuniculi in vitro.
abstract: The acaricidal activity of trans-cinnamaldehyde was evaluated in vitro on Psoroptes cuniculi. In this study, different concentrations of trans-cinnamaldehyde were tested, and the observed mites mortality was compared with that observed in untreated and treated (Acacerulen R®) controls. The morphological changes in P. cuniculi treated with trans-cinnamaldehyde were examined with light microscopy. By the analysis of variance one-way test, up to 8 μg/ml of trans-cinnamaldehyde gave highly significant (P < 0.01) percentages of mite mortality compared with the untreated controls, but only up to 256 μg/ml, it showed the same efficacy of Acacerulen R®. At the same time, a bioassay was conducted by exposing mites to varying doses of trans-cinnamaldehyde in vitro cultures. The resulting data were analyzed by using a time-dose-mortality modeling technique, yielding the parameters for time and dose effects of P. cuniculi. The β value was 2.01, indicating that trans-cinnamaldehyde had a good activity to kill P. cuniculi adults. Based on the time-dose-mortality relationships fitted and the virulence indices estimated, trans-cinnamaldehyde is a promising microbial agent for mites control.
authors.affiliation: Key Laboratory for Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Animal Science and Veterinary Medicine, Jilin University, Changchun 130062, People's Republic of China.
authors.forename: Fengge
authors.initials: F
authors.lastname: Shen
authors.forename: Mingxun
authors.initials: M
authors.lastname: Xing
authors.forename: Lihui
authors.initials: L
authors.lastname: Liu
authors.forename: Xudong
authors.initials: X
authors.lastname: Tang
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Wang
authors.forename: Xiuping
authors.initials: X
authors.lastname: Wu
authors.forename: Xuelin
authors.initials: X
authors.lastname: Wang
authors.forename: Xinrui
authors.initials: X
authors.lastname: Wang
authors.forename: Guangming
authors.initials: G
authors.lastname: Wang
authors.forename: Junhui
authors.initials: J
authors.lastname: Zhang
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.forename: Jiyu
authors.initials: J
authors.lastname: Zhang
authors.forename: Lu
authors.initials: L
authors.lastname: Yu
mesh_terms: D056810:Acaricides / Q000494:pharmacology*; D000171:Acrolein / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D002366:Cassia / Q000737:chemistry; D008924:Mite Infestations / Q000188:drug therapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D010938:Plant Oils / Q000737:chemistry / Q000494:pharmacology*; D040042:Psoroptidae / Q000187:drug effects*; D013983:Tick Control / Q000379:methods
chemical_list: D056810:Acaricides; D010936:Plant Extracts; D010938:Plant Oils; D000171:Acrolein; C012843:cinnamaldehyde