title: Can metabolic syndrome predict the vulnerable plaque in patients with stable angina pectoris? Virtual histology-intravascular ultrasound analysis.
abstract: BACKGROUND
  Vulnerable plaque in coronary artery can progress to plaque rupture and thrombosis, and have a strong potential to induce acute coronary syndrome. Many studies have demonstrated that metabolic syndrome (MetS) is associated with increased risk for cardiovascular diseases and related mortalities.
  
  
  METHODS
  From September 2007 to June 2010, a total of 239 patients with stable angina pectoris (SAP) who underwent coronary angiogram and intravascular ultrasound (IVUS) were categorized into two groups: MetS group (n=100, 56 men, 64.7±9.5years) and non-MetS group (n=139, 98 men, 60.2±8.4 years).
  
  
  RESULTS
  MetS group showed more frequent multivessel involvement (p=0.026) and had more distal target vessel in coronary artery (p=0.005) than non-MetS group, but IVUS findings showed no significant difference between the two groups. In addition, low high-density lipoprotein (HDL) cholesterol level as the criteria of MetS was observed in virtual histology (VH)-derived thin cap fibroatheroma (TCFA) group more than stable plaque group (p=0.020), but the prevalence of MetS and other components of MetS were not different between the two groups. Multivariate analysis using logistic regression for the presence of VH-derived TCFA showed that the independent predictor is the low HDL cholesterol level (odds ratio=3.563, 95% confidence interval=1.370-9.269, p=0.009).
  
  
  CONCLUSIONS
  The presence of MetS was not associated with VH-derived TCFA in patients with SAP.
authors.affiliation: Heart Center of Chonnam National University Hospital, Gwangju, Republic of Korea.
authors.forename: Min Goo
authors.initials: MG
authors.lastname: Lee
authors.forename: Myung Ho
authors.initials: MH
authors.lastname: Jeong
authors.forename: Dong Han
authors.initials: DH
authors.lastname: Kim
authors.forename: Ki Hong
authors.initials: KH
authors.lastname: Lee
authors.forename: Keun Ho
authors.initials: KH
authors.lastname: Park
authors.forename: Doo Sun
authors.initials: DS
authors.lastname: Sim
authors.forename: Nam Sik
authors.initials: NS
authors.lastname: Yoon
authors.forename: Hyun Ju
authors.initials: HJ
authors.lastname: Yoon
authors.forename: Kye Hun
authors.initials: KH
authors.lastname: Kim
authors.forename: Hyung Wook
authors.initials: HW
authors.lastname: Park
authors.forename: Young Joon
authors.initials: YJ
authors.lastname: Hong
authors.forename: Ju Han
authors.initials: JH
authors.lastname: Kim
authors.forename: Youngkeun
authors.initials: Y
authors.lastname: Ahn
authors.forename: Jeong Gwan
authors.initials: JG
authors.lastname: Cho
authors.forename: Jong Chun
authors.initials: JC
authors.lastname: Park
authors.forename: Jung Chaee
authors.initials: JC
authors.lastname: Kang
mesh_terms: D054058:Acute Coronary Syndrome / Q000209:etiology; D000368:Aged; D060050:Angina, Stable / Q000000981:diagnostic imaging* / Q000209:etiology*; D008076:Cholesterol, HDL / Q000097:blood; D017023:Coronary Angiography; D003331:Coronary Vessels / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications*; D008875:Middle Aged; D058226:Plaque, Atherosclerotic / Q000150:complications*; D012189:Retrospective Studies; D012306:Risk; D012307:Risk Factors; D018084:Ultrasonography, Interventional
chemical_list: D008076:Cholesterol, HDL