title: Stereoselective synthesis of fluorinated 2,3-dihydroquinolin-4(1H)-ones via a one-pot multistep transformation.
abstract: A new organocatalytic one-pot multistep transformation via Knoevenagel condensation/aza-Michael addition/electrophilic fluorination has been developed. Simple starting materials were used under mild conditions to construct fluorinated 2,3-dihydroquinolin-4(1H)-one derivatives in good to high yields (up to 98%) and diastereoselectivities (dr up to 99/1).
authors.affiliation: Department of Chemistry, Tianjin University, Tianjin, 300072, P. R. of China.
authors.forename: Feng
authors.initials: F
authors.lastname: Li
authors.forename: Jing
authors.initials: J
authors.lastname: Nie
authors.forename: Jun-Wei
authors.initials: JW
authors.lastname: Wu
authors.forename: Yan
authors.initials: Y
authors.lastname: Zheng
authors.forename: Jun-An
authors.initials: JA
authors.lastname: Ma
mesh_terms: D018360:Crystallography, X-Ray; D008958:Models, Molecular; D015394:Molecular Structure; D015363:Quinolones / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: C545227:2,3-dihydroquinolin-4(1H)-one; D015363:Quinolones