title: Vitamin D and osteoporosis-related fracture.
abstract: The age-related decline in mass and quality of bone (osteoporosis) and muscle (sarcopenia) leads to an exponential increased risk for osteoporosis-related fracture with advancing age in older adults. As vitamin D inadequacy plausibly causally contributes to these declines, optimization of vitamin D status might reduce the deterioration of bone and muscle function with age. Putative mechanisms by which vitamin D inadequacy may increase fracture risk include both direct and indirect effects on bone and muscle. However, controversy currently clouds the role(s) of vitamin D in osteoporosis-related fracture, the amount of vitamin D required and the optimal 25-hydroxyvitamin D level. This review provides an overview of current knowledge and suggests a clinical approach to vitamin D status in older adults with, or at risk for, osteoporosis-related fracture. These recommendations are likely to evolve as additional data becomes available.
authors.affiliation: University of Wisconsin Osteoporosis Clinical Research Program, University of Wisconsin-Madison, WI 53705, USA. nbinkley@facstaff.wisc.edu
authors.forename: Neil
authors.initials: N
authors.lastname: Binkley
mesh_terms: D000058:Accidental Falls; D015519:Bone Density / Q000187:drug effects; D006801:Humans; D058866:Osteoporotic Fractures / Q000150:complications / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D055948:Sarcopenia / Q000150:complications / Q000378:metabolism; D014807:Vitamin D / Q000378:metabolism* / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D014807:Vitamin D