title: Diffusion-weighted MRI as an adjunct to mammography in women under 50 years of age: an initial study.
abstract: OBJECTIVE
  To evaluate diffusion-weighted magnetic resonance (DW) imaging as an adjunct to mammography for the detection of small invasive breast cancer.
  
  
  METHODS
  Institutional review board standards were followed for this retrospective study. We performed both breast DW imaging and mammography on 25 women under 50 years of age with pathologically proven T1 breast cancer and on 21 healthy women under 50 years of age. Four offsite radiologists blind to the clinical information independently interpreted the mammograms and DW images and then classified their confidence level regarding the presence of breast cancer. The composite area under receiver operating characteristic curve (AUC), of mammography alone, DW imaging alone, and the combination of DW imaging and mammography (DWI/Cal) were calculated.
  
  
  RESULTS
  The AUC of composite ROC curves of mammography, DW imaging, DWI/Cal combination, was 0.79 (95% CI, 0.72-0.87), 0.86 (95% CI, 0.84-0.87), and 0.96 (95% CI, 0.92-1.00), respectively.
  
  
  CONCLUSIONS
  DW imaging may be a useful adjunct to mammography in the detection of small invasive breast cancer in women under 50 years of age.
authors.affiliation: Department of Radiology, Chiba University Hospital, Chiba, Japan. kazamat@fg7.so-net.ne.jp
authors.forename: Toshiki
authors.initials: T
authors.lastname: Kazama
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Kuroki
authors.forename: Mari
authors.initials: M
authors.lastname: Kikuchi
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Sato
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nagashima
authors.forename: Yukimasa
authors.initials: Y
authors.lastname: Miyazawa
authors.forename: Masahiro
authors.initials: M
authors.lastname: Sakakibara
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Kaneoya
authors.forename: Yumi
authors.initials: Y
authors.lastname: Makimoto
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Hashimoto
authors.forename: Ken
authors.initials: K
authors.lastname: Motoori
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Takano
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000175:diagnosis*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D008327:Mammography / Q000379:methods*; D008875:Middle Aged; D015588:Observer Variation; D010865:Pilot Projects; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity