title: Effects of direct cedrol inhalation into the lower airway on brain hemodynamics in totally laryngectomized subjects.
abstract: A previous study reported that when cedrol (odorant) is inhaled directly through the lower airway of the trachea, it decreases the sympathetic nervous activity and blood pressure in totally laryngectomized subjects (Umeno et al., 2008). In the present study, totally laryngectomized subjects were asked to inhale cedrol into the lower airway in the same manner and its effects on regional cerebral blood flow (rCBF) were analyzed. Our results indicated that hippocampal rCBF was bilaterally increased during cedrol inhalation as compared to the inhalation of blank air. These results provide the first evidence that an odorant in the lower airway modulates autonomic activity via the central nervous system.
authors.affiliation: System Emotional Science, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Japan.
authors.forename: Etsuro
authors.initials: E
authors.lastname: Hori
authors.forename: Hideo
authors.initials: H
authors.lastname: Shojaku
authors.forename: Naoto
authors.initials: N
authors.lastname: Watanabe
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Kawasaki
authors.forename: Michio
authors.initials: M
authors.lastname: Suzuki
authors.forename: Mariana F P
authors.initials: MF
authors.lastname: de Araujo
authors.forename: Yoshinao
authors.initials: Y
authors.lastname: Nagashima
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Yada
authors.forename: Taketoshi
authors.initials: T
authors.lastname: Ono
authors.forename: Hisao
authors.initials: H
authors.lastname: Nishijo
mesh_terms: D000280:Administration, Inhalation; D000368:Aged; D000679:Amygdala / Q000098:blood supply / Q000000981:diagnostic imaging; D001341:Autonomic Nervous System / Q000000981:diagnostic imaging / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000000981:diagnostic imaging; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D007839:Functional Laterality / Q000502:physiology; D006624:Hippocampus / Q000098:blood supply / Q000000981:diagnostic imaging; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007825:Laryngectomy; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000098:blood supply / Q000000981:diagnostic imaging; D009812:Odorants; D017933:Peripheral Nervous System / Q000000981:diagnostic imaging / Q000187:drug effects; D000081223:Polycyclic Sesquiterpenes; D013729:Terpenes / Q000008:administration & dosage / Q000494:pharmacology*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D000081223:Polycyclic Sesquiterpenes; D013729:Terpenes; C078669:cedrol