title: A new method for cancer detection based on diffusion reflection measurements of targeted gold nanorods.
abstract: This paper presents a new method for cancer detection based on diffusion reflection measurements. This method enables discrimination between cancerous and noncancerous tissues due to the intense light absorption of gold nanorods (GNRs), which are selectively targeted to squamous cell carcinoma head and neck cancer cells. Presented in this paper are tissue-like phantom and in vivo results that demonstrate the high sensitivity of diffusion reflection measurements to the absorption differences between the GNR-targeted cancerous tissue and normal, noncancerous tissue. This noninvasive and nonionizing optical detection method provides a highly sensitive, simple, and inexpensive tool for cancer detection.
authors.affiliation: Faculty of Engineering and the Institute of Nanotechnology and Advanced Materials, Bar Ilan University, Ramat Gan 52900, Israel.
authors.forename: Rinat
authors.initials: R
authors.lastname: Ankri
authors.forename: Vital
authors.initials: V
authors.lastname: Peretz
authors.forename: Menachem
authors.initials: M
authors.lastname: Motiei
authors.forename: Rachela
authors.initials: R
authors.lastname: Popovtzer
authors.forename: Dror
authors.initials: D
authors.lastname: Fixler
mesh_terms: D000042:Absorption; D000818:Animals; D000906:Antibodies; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis*; D045744:Cell Line, Tumor; D004058:Diffusion; D066246:ErbB Receptors; D006046:Gold / Q000737:chemistry*; D006258:Head and Neck Neoplasms / Q000175:diagnosis*; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D008819:Mice, Nude; D057054:Molecular Imaging / Q000379:methods*; D043942:Nanotubes / Q000737:chemistry*; D009374:Neoplasms, Experimental; D019047:Phantoms, Imaging
chemical_list: D000906:Antibodies; D006046:Gold; C512478:EGFR protein, human; D066246:ErbB Receptors