title: One-pot synthesis of a piperidine-based rigidified DTPA analogue and its bifunctional chelating agent.
abstract: The core structure of cis-3,5-diaminopiperidine was N-alkylated with excess t-butylbromoacetate in order to exploit the successive N-quaternarization and Stevens rearrangement to access the pentaalkylated product and the bifunctional chelating agent containing a N-butanedioic acid pendant arm at the same time. The relaxometric properties of the Gd(III) complexes with these ligands were studied also in terms of pH and serum stabilities.
authors.affiliation: Dipartimento di Scienze e Innovazione Tecnologica, Università del Piemonte Orientale A. Avogadro, Viale T. Michel 11, 15121 Alessandria, Italy. lorenzo.tei@mfn.unipmn.it
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Tei
authors.forename: Gabriele A
authors.initials: GA
authors.lastname: Rolla
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Gugliotta
authors.forename: Mauro
authors.initials: M
authors.lastname: Botta
mesh_terms: D000478:Alkylation; D002614:Chelating Agents / Q000138:chemical synthesis*; D008024:Ligands; D015394:Molecular Structure; D004369:Pentetic Acid / Q000031:analogs & derivatives*; D010880:Piperidines / Q000737:chemistry*
chemical_list: D002614:Chelating Agents; D008024:Ligands; D010880:Piperidines; C032727:piperidine; D004369:Pentetic Acid