title: Prediction of the lipophilicity of nine new synthesized selenazoly and three aroyl-hydrazinoselenazoles derivatives by reversed-phase high performance thin-layer chromatography.
abstract: Using reversed-phase high-performance thin-layer chromatography and a methanol-water mixture as the mobile phase, the lipophilicity of 12 new synthesized derivatives is studied. The first eight compounds have as a basic chemical structure aryliden-hydrazino-selenazoles, and the second group of the three compounds belongs to aroyl-hydrazinoselenazoles. The linear correlation between R(Mw) and the methanol-water ratios showed high values for the correlation coefficient. The chromatographic hydrophobic index is determined by using the ratio -R(Mw)/S, and the obtained values ranged between 99 and 73. A good linear correlation is obtained between R(Mw) and the slope. The log P values are calculated using ACD/Labs Software. The matrices are formed with R(Mw) and log P and are subjected to a principal component analysis (PCA). The best way to extract information from PCA is graphically, by plotting the obtained matrices. By analyzing the scores, the compounds can be grouped as follows: a group containing nine compounds, and a second one containing three compounds. Each group of compounds has the same basic chemical structure.
authors.affiliation: University of Oradea, Faculty of Science, Department of Chemistry, Romania.
authors.forename: A
authors.initials: A
authors.lastname: Cozma
authors.forename: V
authors.initials: V
authors.lastname: Zaharia
authors.forename: A
authors.initials: A
authors.lastname: Ignat
authors.forename: S
authors.initials: S
authors.lastname: Gocan
authors.forename: N
authors.initials: N
authors.lastname: Grinberg
mesh_terms: D001393:Azoles / Q000737:chemistry* / Q000302:isolation & purification; D056148:Chromatography, Reverse-Phase / Q000379:methods*; D002855:Chromatography, Thin Layer / Q000379:methods*; D006834:Hydrazines / Q000737:chemistry* / Q000302:isolation & purification; D057927:Hydrophobic and Hydrophilic Interactions; D016014:Linear Models; D000432:Methanol / Q000737:chemistry; D016566:Organoselenium Compounds / Q000737:chemistry* / Q000302:isolation & purification; D025341:Principal Component Analysis
chemical_list: D001393:Azoles; D006834:Hydrazines; D016566:Organoselenium Compounds; D000432:Methanol