title: CG Dinucleotides of class II MHC genes are mutation hot-spots.
abstract: DNA methylation of human class II genes of the Major Histocompatibility Complex (MHC) was correlated with gene expression and methyl-related CG → TG and CG → CA changes. It was found that cytosine methylation of the CG dinucleotides of MHC class II genes should be involved in generating a fraction of nucleotide polymorphism, rather than in controlling transcription.
authors.affiliation: Istituto di Chimica Biologica, Università di Ferrara, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Gambari
authors.forename: R
authors.initials: R
authors.lastname: Piva
authors.forename: S
authors.initials: S
authors.lastname: Volinia
authors.forename: P
authors.initials: P
authors.lastname: Orlando
authors.forename: C
authors.initials: C
authors.lastname: Nastruzzi
authors.forename: P
authors.initials: P
authors.lastname: Giacomini
authors.forename: P G
authors.initials: PG
authors.lastname: Natali
authors.forename: R
authors.initials: R
authors.lastname: Barbieri