title: Physangulidines A, B, and C: three new antiproliferative withanolides from Physalis angulata L.
abstract: Bioassay-directed fractionation of the whole plant of Physalis angulata L. afforded three new antiproliferative withanolides with an unusual carbon framework: physangulidines A (1), B (2), and C (3). Structures of the three isomeric withanolides were determined by a combination of HRMS, NMR spectroscopic, and X-ray crystallographic methods. Each has shown significant antiproliferative activity against DU145 prostate cancer cells. Physangulidine A (1) was further tested against a wide range of additional cancer cell lines and found to exhibit significant antiproliferative activity.
authors.affiliation: Department of Chemistry, University of Louisville, Louisville, Kentucky 40292, USA.
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Jin
authors.forename: Mark S
authors.initials: MS
authors.lastname: Mashuta
authors.forename: Neal J
authors.initials: NJ
authors.lastname: Stolowich
authors.forename: Abraham J
authors.initials: AJ
authors.lastname: Vaisberg
authors.forename: Nicole S
authors.initials: NS
authors.lastname: Stivers
authors.forename: Paula J
authors.initials: PJ
authors.lastname: Bates
authors.forename: Walter H
authors.initials: WH
authors.lastname: Lewis
authors.forename: Gerald B
authors.initials: GB
authors.lastname: Hammond
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D019684:Magnoliopsida / Q000737:chemistry*; D051379:Mice; D008958:Models, Molecular; D008968:Molecular Conformation; D054358:Withanolides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D054358:Withanolides; C572271:physangulidine A; C572272:physangulidine B; C572273:physangulidine C