title: Latency type-dependent modulation of Epstein-Barr virus-encoded latent membrane protein 1 expression by type I interferons in B cells.
abstract: We report that type I interferons (IFNs) upregulate latent membrane protein 1 (LMP-1) expression by direct activation of the ED-L1 promoter in several Epstein-Barr virus (EBV)-carrying Burkitt's lymphoma lines. In EBV-infected primary B cells, IFN-α transiently upregulates LMP-1 mRNA, but not protein levels, followed by downregulation of both, suggesting a novel antiproliferative mechanism of type I IFNs. Furthermore, our results may explain the expression of LMP-1 in memory B cells of systemic lupus erythematosus patients.
authors.affiliation: Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden. Daniel.Salamon@ki.se
authors.forename: Daniel
authors.initials: D
authors.lastname: Salamon
authors.forename: Monika
authors.initials: M
authors.lastname: Adori
authors.forename: Dorina
authors.initials: D
authors.lastname: Ujvari
authors.forename: Liang
authors.initials: L
authors.lastname: Wu
authors.forename: Lorand L
authors.initials: LL
authors.lastname: Kis
authors.forename: Harsha S
authors.initials: HS
authors.lastname: Madapura
authors.forename: Noemi
authors.initials: N
authors.lastname: Nagy
authors.forename: George
authors.initials: G
authors.lastname: Klein
authors.forename: Eva
authors.initials: E
authors.lastname: Klein
mesh_terms: D001402:B-Lymphocytes / Q000187:drug effects / Q000378:metabolism* / Q000821:virology; D002460:Cell Line; D015967:Gene Expression Regulation, Viral / Q000187:drug effects; D004854:Herpesvirus 4, Human / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007370:Interferon Type I / Q000378:metabolism* / Q000494:pharmacology; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D015398:Signal Transduction / Q000187:drug effects; D014158:Transcription, Genetic; D014763:Viral Matrix Proteins / Q000235:genetics* / Q000378:metabolism; D017735:Virus Latency
chemical_list: C037662:EBV-associated membrane antigen, Epstein-Barr virus; D007370:Interferon Type I; D014763:Viral Matrix Proteins