title: Association between OLR1 K167N SNP and intima media thickness of the common carotid artery in the general population.
abstract: OBJECTIVE
  The lectin-like oxidised LDL receptor-1 (OLR1) gene encodes a scavenger receptor implicated in the pathogenesis of atherosclerosis. Although functional roles have been suggested for two variants, epidemiological studies on OLR1 have been inconsistent.
  
  
  METHODS
  We tested the association between the non-synonymous substitution K167N (rs11053646) and intima media thickness of the common carotid artery (CCA-IMT) in 2,141 samples from the Progression of Lesions in the Intima of the Carotid (PLIC) study (a prospective population-based study).
  
  
  RESULTS
  Significantly increased IMT was observed in male carriers of the minor C (N) allele compared to GC and GG (KN and KK) genotype. Functional analysis on macrophages suggested a decreased association to Ox-LDL in NN carriers compared to KN and KK carriers which is also associated with a reduced OLR1 mRNA expression. Macrophages from NN carriers present also a specific inflammatory gene expression pattern compared to cells from KN and KK carriers.
  
  
  CONCLUSIONS
  These data suggest that the 167N variant of LOX-1 receptor affects the atherogenic process in the carotid artery prior to evidence of disease through an inflammatory process.
authors.affiliation: Department of Biopathology and Diagnostic Imaging, Section of Medical Genetics, School of Medicine, Tor Vergata University, Rome, Italy. irene.m.predazzi@Vanderbilt.Edu
authors.forename: Irene Marta
authors.initials: IM
authors.lastname: Predazzi
authors.forename: Giuseppe Danilo
authors.initials: GD
authors.lastname: Norata
authors.forename: Lucia
authors.initials: L
authors.lastname: Vecchione
authors.forename: Katia
authors.initials: K
authors.lastname: Garlaschelli
authors.forename: Francesca
authors.initials: F
authors.lastname: Amati
authors.forename: Liliana
authors.initials: L
authors.lastname: Grigore
authors.forename: Lucia
authors.initials: L
authors.lastname: Cutuli
authors.forename: Angela
authors.initials: A
authors.lastname: Pirillo
authors.forename: Simona
authors.initials: S
authors.lastname: Tramontana
authors.forename: Francesco
authors.initials: F
authors.lastname: Romeo
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Novelli
authors.forename: Alberico Luigi
authors.initials: AL
authors.lastname: Catapano
mesh_terms: D019943:Amino Acid Substitution; D002340:Carotid Artery Diseases / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology*; D017536:Carotid Artery, Common / Q000473:pathology*; D005260:Female; D005838:Genotype; D006801:Humans; D007249:Inflammation; D008264:Macrophages; D008297:Male; D020641:Polymorphism, Single Nucleotide; D051127:Scavenger Receptors, Class E / Q000235:genetics*; D012737:Sex Factors; D017539:Tunica Intima / Q000473:pathology; D017540:Tunica Media / Q000473:pathology
chemical_list: C495137:OLR1 protein, human; D051127:Scavenger Receptors, Class E