title: Latest advances towards the discovery of 5-HT(7) receptor ligands.
abstract: The 5-HT(7)receptor (5-HT(7)R), characterized in 1993, is the most recently described member of the serotonin family. Since its discovery, 5-HT(7)R has been the subject of extensive research due to its widespread distribution in the brain, suggestive of multiple central roles. The focus of this review is to illustrate the literature concerning developments of the last few years (2007-2010) towards the discovery of novel and selective 5-HT(7)R ligands, agonists, antagonist and inverse agonists.
authors.affiliation: Dipartimento di Scienze del Farmaco, Universita di Catania, Catania, Italy. vpittala@unict.it
authors.forename: V
authors.initials: V
authors.lastname: Pittala
authors.forename: D
authors.initials: D
authors.lastname: Pittala
mesh_terms: D000818:Animals; D055808:Drug Discovery; D006801:Humans; D008024:Ligands; D011985:Receptors, Serotonin / Q000378:metabolism*; D012702:Serotonin Antagonists / Q000737:chemistry* / Q000494:pharmacology*; D017366:Serotonin Receptor Agonists / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D008024:Ligands; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; C104425:serotonin 7 receptor