title: Diagnostic utility of vitreous humor fluid cytology for intraocular sarcoidosis: a clinicopathologic study of 7 cases.
abstract: Sarcoidosis is an enigmatic multisystem sarcoid disease occurring mainly in the lungs, skin, and eyes. Sarcoidosis of the eyes (intraocular sarcoidosis) has been proposed as one of the causes of uveitis. We carried out a clinicopathological study involving seven patients with intraocular sarcoidosis based on vitreous humor fluid cytology. In the seven patients, the sex ratio was 4:3, and the average age at onset was 65.6-years-old. Vitreous opacity was noted in all patients and snowball-like vitreous opacity in 85.7%. Nerve papilloedema was noted in 42.9%. Diagnostic vitrectomy and adrenocortical hormone therapy were performed in all patients. As a result, the symptoms were improved. Vitreous perfusion fluid cytology revealed multinucleate giant cells in 85.7% and lymphocytes and epithelioid cells in all cases. Cytological diagnosis is not included in the current criteria for sarcoidosis, but its value in the diagnosis of intraocular sarcoidosis was suggested based in present study.
authors.affiliation: Department of Cytopathology, Kansai Medical University Takii Hospital, Osaka, Japan. kinoshyu@takii.kmu.ac.jp
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Kinoshita
authors.forename: Kosho
authors.initials: K
authors.lastname: Takasu
authors.forename: Yasuhi
authors.initials: Y
authors.lastname: Adachi
authors.forename: Takashi
authors.initials: T
authors.lastname: Yuri
authors.forename: Shiho
authors.initials: S
authors.lastname: Matsunaga
authors.forename: Sachiko
authors.initials: S
authors.lastname: Nagumo
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Shikata
mesh_terms: D000328:Adult; D000368:Aged; D003581:Cytodiagnosis; D005128:Eye Diseases / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012507:Sarcoidosis / Q000175:diagnosis*; D014822:Vitreous Body / Q000473:pathology*