title: Association of cellular adhesion molecules and oxidative stress with endothelial function in obstructive sleep apnea.
abstract: OBJECTIVE
  To evaluate the impact of oxidative stress and cellular adhesion molecules on ischemic reactive hyperemia (IRH) in patients with OSA.
  
  
  METHODS
  Consecutive patients treated at a sleep laboratory and whose polysomnography showed an apnea hypopnea index (AHI) ≥5 were included in the study. Patients with acute illness receiving vasoactive medications were excluded. Based on their oxygen desaturation index (ODI), subjects were assigned to the mild-moderate (ODI ≤30) or the severe desaturation group (ODI >30). Then IRH and oxidative stress markers [malondialdehyde (MDA)] and proinflammatory markers (ICAM-1 and P-selectin) were measured.
  
  
  RESULTS
  Sixty-eight subjects with OSA were included, 31 in the mild-moderate desaturation group and 37 in the severe group. No differences by age, gender and body mass index were observed. The severe desaturation group showed significantly higher values in the AHI, MDA, ICAM-1 and P-selectin (p<0.005), as well as a worsening of IRH (p=0.001). Only ICAM-1 (p=0.019) and P-selectin (p=0.033) were independently associated with IRH in a multiple-linear regression model.
  
  
  CONCLUSIONS
  Patients with OSA and greater intermittent hypoxia showed worse endothelial function, and higher levels of MDA, ICAM-1 and P-selectin. Nevertheless, ICAM-1 and P-selectin rather than MDA were independently associated with IRH.
authors.affiliation: Sleep Unit, Department of Pulmonary Medicine, Reina Sofia University Hospital, Spain. bjg01co@hotmail.com
authors.forename: Bernabe
authors.initials: B
authors.lastname: Jurado-Gamez
authors.forename: Carlos
authors.initials: C
authors.lastname: Bujalance Cabrera
authors.forename: Laura
authors.initials: L
authors.lastname: Caballero Ballesteros
authors.forename: Carmen
authors.initials: C
authors.lastname: Marin Hinojosa
authors.forename: Luis
authors.initials: L
authors.lastname: Muñoz Cabrera
authors.forename: Francisco
authors.initials: F
authors.lastname: Perez-Jimenez
authors.forename: Jose
authors.initials: J
authors.lastname: Lopez-Miranda
mesh_terms: D000328:Adult; D000368:Aged; D050197:Atherosclerosis; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D015815:Cell Adhesion Molecules / Q000097:blood / Q000502:physiology*; D042783:Endothelial Cells / Q000502:physiology*; D005260:Female; D006801:Humans; D006940:Hyperemia / Q000503:physiopathology*; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D017078:Laser-Doppler Flowmetry; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D019007:P-Selectin / Q000097:blood; D017286:Polysomnography; D011446:Prospective Studies; D020181:Sleep Apnea, Obstructive / Q000503:physiopathology*
chemical_list: D015415:Biomarkers; D015815:Cell Adhesion Molecules; D019007:P-Selectin; D018799:Intercellular Adhesion Molecule-1; D008315:Malondialdehyde