title: [The genes disposing to malignant melanoma--a systematic review].
abstract: Denmark is a high-risk country for malignant melanoma (MM).The incidence of MM has increased faster than the ones of any other cancer during the last ten years. 5-10% of the patients with MM report a family history of MM, and this is most likely caused by a combination of genetic and environmental factors. The genes disposing to MM are reviewed in this article and the challenges and ethical considerations concerning genetic counselling of families at high risk of MM are discussed.
authors.affiliation: Klinisk Genetisk Afdeling 4062, Blegdamsvej 9, Rigshospitalet, 2100 København Ø, Denmark. karin.wadt@rh.regionh.dk
authors.forename: Karin Anna Wallentin
authors.initials: KA
authors.lastname: Wadt
authors.forename: Krzysztof Tadeusz
authors.initials: KT
authors.lastname: Drzewiecki
authors.forename: Anne-Marie Axø
authors.initials: AM
authors.lastname: Gerdes
mesh_terms: D051358:Cyclin-Dependent Kinase 4 / Q000235:genetics; D019942:Genes, p16; D005817:Genetic Counseling; D020022:Genetic Predisposition to Disease; D006801:Humans; D008545:Melanoma / Q000235:genetics*; D009154:Mutation; D012307:Risk Factors; D012878:Skin Neoplasms / Q000235:genetics*
chemical_list: D051358:Cyclin-Dependent Kinase 4