title: Pharmacokinetics and administration method of gentamicin in a patient on haemodialysis.
abstract: We investigated the pharmacokinetics of gentamicin in a haemodialysis patient treated for endocarditis caused by methicillin-resistant Staphylococcus aureus and found that the administration of gentamicin immediately prior to dialysis was a suitable strategy for reaching target maximum drug concentration (Cmax) values and low trough levels.
authors.affiliation: Department of Pharmacy, National Hospital Organization Kumamoto Medical Center, Kumamoto City, Kumamoto, Japan. hiraki@kumamoto2.hosp.go.jp
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Hiraki
authors.forename: Mikako
authors.initials: M
authors.lastname: Hiraike
authors.forename: Masahisa
authors.initials: M
authors.lastname: Nagano
authors.forename: Yukari
authors.initials: Y
authors.lastname: Ozono
authors.forename: Kenichi
authors.initials: K
authors.lastname: Manabe
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Misumi
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Tsuji
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Kamimura
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Karube
mesh_terms: D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D004697:Endocarditis, Bacterial / Q000188:drug therapy / Q000378:metabolism / Q000382:microbiology; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus / Q000302:isolation & purification; D006435:Renal Dialysis; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins