title: A molecular light switch Ru complex and quantum dots for the label-free, aptamer-based detection of thrombin.
abstract: A simple, label-free method for the detection of thrombin has been developed based on the conformational transition of aptamer in the presence of the target by using a molecular light switch, Ru polypyridine complex, and quantum dots as novel fluorescence probes in aqueous solution.
authors.affiliation: Department of Chemistry, Tongji University, Shanghai 200092, China.
authors.forename: Wenliang
authors.initials: W
authors.lastname: Sun
authors.forename: Tianming
authors.initials: T
authors.lastname: Yao
authors.forename: Shuo
authors.initials: S
authors.lastname: Shi
mesh_terms: D052157:Aptamers, Nucleotide / Q000737:chemistry*; D002623:Chemistry Techniques, Analytical / Q000379:methods*; D006801:Humans; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D045663:Quantum Dots; D012428:Ruthenium / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D013194:Staining and Labeling; D013917:Thrombin / Q000032:analysis* / Q000737:chemistry
chemical_list: D052157:Aptamers, Nucleotide; D009942:Organometallic Compounds; D012428:Ruthenium; D013917:Thrombin