title: Genetics of mammalian reproduction: modeling the end of the germline.
abstract: Our understanding of reproduction and early embryonic development has directly enabled our manipulation of the mouse genome for tests of gene function in vivo. In this review, we reflect on the 30 years of work that followed this singular accomplishment. We profile murine models that have given us memorable insights into fundamental processes of male and female gametogenesis and the earliest phases of embryonic life reliant on oocyte-transmitted maternal gene products. We highlight intercellular endocrine and paracrine communications essential to gamete development as well as mechanisms essential for passing the genome, with integrity and appropriate epigenetic marks, on to the next generation. Finally, we reflect on the future of reproductive biology: how advances in clinical genetics will provide special opportunities to understand which reproductive processes are affected by genetic lesions and which may allow mutations to originate.
authors.affiliation: Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA. mmatzuk@bcm.edu
authors.forename: Martin M
authors.initials: MM
authors.lastname: Matzuk
authors.forename: Kathleen H
authors.initials: KH
authors.lastname: Burns
mesh_terms: D000328:Adult; D000818:Animals; D041322:Chromosomes, Human, Y / Q000235:genetics; D047108:Embryonic Development / Q000235:genetics / Q000502:physiology; D005260:Female; D005821:Genetic Techniques; D005823:Genetics / Q000639:trends; D005854:Germ Cells / Q000502:physiology*; D006801:Humans; D007246:Infertility / Q000235:genetics; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D011247:Pregnancy; D012098:Reproduction / Q000235:genetics* / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics; D016212:Transforming Growth Factor beta / Q000235:genetics
chemical_list: D016212:Transforming Growth Factor beta