title: Clinicopathologic change of gastrointestinal stromal tumor after neoadjuvant imatinib followed by surgical resection.
abstract: A 53-year-old woman was diagnosed with gastrointestinal stromal tumor (GIST) of the stomach. Computed tomography (CT) revealed a huge mass (12 cm in diameter), likely to invade pancreas and spleen. In the operation field, the tumor was in an unresectable state. The patient was then started on imatinib therapy for 4 months. On follow-up imaging studies, the tumor almost disappeared. We performed total gastrectomy and splenectomy upon which two small-sized residual tumors were found on microscopy. In this paper, we describe a case of clinicopathologic change in unresectable GIST after neoadjuvant imatinib mesylate.
authors.affiliation: Department of Surgery, Soonchunhyang University Cheonan Hospital, Soonchunhyang University College of Medicine, Cheonan, Korea.
authors.forename: Gil Ho
authors.initials: GH
authors.lastname: Kang
authors.forename: Myoung Won
authors.initials: MW
authors.lastname: Son
authors.forename: Sun Wook
authors.initials: SW
authors.lastname: Han
authors.forename: Sang Ho
authors.initials: SH
authors.lastname: Bae
authors.forename: Sung Yong
authors.initials: SY
authors.lastname: Kim
authors.forename: Yong Jin
authors.initials: YJ
authors.lastname: Kim
authors.forename: Gui Ae
authors.initials: GA
authors.lastname: Chung
authors.forename: Gyu Seok
authors.initials: GS
authors.lastname: Cho
authors.forename: Moon Soo
authors.initials: MS
authors.lastname: Lee
authors.forename: Nae Kyeong
authors.initials: NK
authors.lastname: Park