title: [Change of serum TGF-beta1 and TNF-alpha in silicosis patients].
abstract: OBJECTIVE
  To observe serum TGF-beta1 and TNF-alpha in silicosis patients and workers exposed to silica dust to study the role of TGF-beta1 and TNF-alpha in the development of silicosis.
  
  
  METHODS
  One hundred non-exposed workers were selected as control group, 200 workers exposed to silica dust for more than 1 year as exposed group, 32 suspected silicosis patients (originally diagnosed as 0+) as observing group, 130 silicosis patients were as silicosis group. Serum TGF-beta1 and TNF-alpha in each group were determined with ELISA.
  
  
  RESULTS
  Serum TNF-alpha in exposed group [(47.86 +/- 16.52) pg/ml], observing group [(109.11 +/- 31.08) pg/ml], silicosis group [(216.35 +/- 51.03) pg/ml] were significantly higher than that in control group [(6.90 +/- 2.24) pg/ml] (P < 0.01); Silicosis group and observing group were also higher than exposed group (P < 0.01, P < 0.05). Compared with control group [(23.28 +/- 12.24) pg/ml] and exposed group [(29.31 +/- 14.52) pg/ml], serum TGF-beta1 in silicosis group was much higher (P < 0.01).
  
  
  CONCLUSIONS
  TGF-beta1, and TNF-alpha were essential in the development of silicosis, so the detection of TGF-beta1 and TNF-alpha in peripheral blood was very useful for occupational health surveillance and early diagnosis of silicosis.
authors.affiliation: Wuxi Hospital for Prevention and Treatment of Occupational Disease, Wuxi, China.
authors.forename: Rong-Ming
authors.initials: RM
authors.lastname: Miao
authors.forename: Xue-Tao
authors.initials: XT
authors.lastname: Zhang
authors.forename: Yu-Lan
authors.initials: YL
authors.lastname: Yan
authors.forename: En-Qi
authors.initials: EQ
authors.lastname: He
authors.forename: Ping
authors.initials: P
authors.lastname: Guo
authors.forename: Ying-Yi
authors.initials: YY
authors.lastname: Zhang
authors.forename: Dao-Kun
authors.initials: DK
authors.lastname: Zhao
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: Yang
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.forename: Ming-Ying
authors.initials: MY
authors.lastname: Yao
authors.forename: Rui
authors.initials: R
authors.lastname: Zhao
authors.forename: Zhong-Hua
authors.initials: ZH
authors.lastname: Fang
authors.forename: Yong-Ming
authors.initials: YM
authors.lastname: Yao
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D012829:Silicosis / Q000097:blood* / Q000175:diagnosis; D053773:Transforming Growth Factor beta1 / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood*
chemical_list: D053773:Transforming Growth Factor beta1; D014409:Tumor Necrosis Factor-alpha