title: Creatine-induced glucose uptake in type 2 diabetes: a role for AMPK-α?
abstract: This study focused on understanding the signaling mechanisms leading to GLUT-4 translocation and increased skeletal-muscle glucose uptake that follow creatine (Cr) supplementation in type 2 diabetes (n = 10). AMPK-α protein content presented a tendency to be higher (p = 0.06) after Cr supplementation (5 g/d for 12w). The changes in AMPK-α protein content significantly related (p < 0.001) to the changes in GLUT-4 translocation (r = 0.78) and Hb1Ac levels (r = -0.68), suggesting that AMPK signaling may be implicated in the effects of supplementation on glucose uptake in type 2 diabetes.
authors.affiliation: School of Physical Education and Sports, University of Sao Paulo, Av Mello de Moraes, 65-Butantã, Sao Paulo, SP, 05508-030, Brazil.
authors.forename: Christiano Robles Rodrigues
authors.initials: CR
authors.lastname: Alves
authors.forename: Júlio César
authors.initials: JC
authors.lastname: Ferreira
authors.forename: Mário Alves
authors.initials: MA
authors.lastname: de Siqueira-Filho
authors.forename: Carla Roberta
authors.initials: CR
authors.lastname: Carvalho
authors.forename: Antonio Herbert
authors.initials: AH
authors.lastname: Lancha
authors.forename: Bruno
authors.initials: B
authors.lastname: Gualano
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000235:genetics / Q000378:metabolism*; D015703:Antigens, CD / Q000235:genetics / Q000378:metabolism; D001706:Biopsy; D003401:Creatine / Q000494:pharmacology* / Q000627:therapeutic use; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000378:metabolism; D004311:Double-Blind Method; D005260:Female; D005786:Gene Expression Regulation / Q000187:drug effects; D005947:Glucose / Q000378:metabolism*; D051275:Glucose Transporter Type 4 / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D019950:Mitogen-Activated Protein Kinase 1 / Q000235:genetics / Q000378:metabolism; D048052:Mitogen-Activated Protein Kinase 3 / Q000235:genetics / Q000378:metabolism; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000378:metabolism; D021381:Protein Transport / Q000187:drug effects; D051057:Proto-Oncogene Proteins c-akt / Q000235:genetics / Q000378:metabolism; D011972:Receptor, Insulin / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D015703:Antigens, CD; D051275:Glucose Transporter Type 4; C435941:INSR protein, human; D011972:Receptor, Insulin; D051057:Proto-Oncogene Proteins c-akt; D019950:Mitogen-Activated Protein Kinase 1; D048052:Mitogen-Activated Protein Kinase 3; D055372:AMP-Activated Protein Kinases; D005947:Glucose; D003401:Creatine