title: Macro CK in patients with elevated troponin I levels.
abstract: CK-MB activity levels can be falsely elevated by the presence of macro CK, especially if immune-inhibition assays are used in the measurement. In patients with macro CK and cardiac pathology that could result in an elevated CK-MB activity, the diagnostic challenge lies in determining the true cause of the elevated CK-MB activity. We present two case reports of patients with elevated CK-MB activity and troponin I levels, but who subsequently had CK-MB activity higher than total CK activity, raising the suspicion of the presence of macro CK.
authors.affiliation: Department of Pathology, Aga Khan University Hospital, Nairobi, Kenya. Ruchika.kohli@aku.edu
authors.forename: Ruchika
authors.initials: R
authors.lastname: Kohli-Kochhar
authors.forename: Evelyne
authors.initials: E
authors.lastname: Mulwa
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Omuse
authors.forename: Peter
authors.initials: P
authors.lastname: Ojwang
mesh_terms: D015415:Biomarkers; D003402:Creatine Kinase; D006801:Humans; D007527:Isoenzymes; D009203:Myocardial Infarction / Q000175:diagnosis; D019210:Troponin I
chemical_list: D015415:Biomarkers; D007527:Isoenzymes; D019210:Troponin I; D003402:Creatine Kinase