title: A novel liposome-encapsulated hemoglobin/silica nanoparticle as an oxygen carrier.
abstract: A novel liposome-encapsulated hemoglobin/silica nanoparticle (LEHSN) was fabricated by a water-in-oil-in-water (W/O/W) double emulsion approach. Bovine hemoglobin (Hb) was first adsorbed onto the surfaces of silica nanoparticles (SNs), and then the complex of Hb/SNs was encapsulated by liposome to form LEHSN which has a core-shell supramolecular structure. On the one hand, liposomes built a cell membrane-like environment for the controlled release of Hb. On the other hand, SNs which act as rigid core provide a supported framework for lecithin membrane, and enhance the stability of liposomes. In comparison with liposome-encapsulated Hb (LEH), LEHSN shows substantially enhanced stability and improved release property of Hb in vitro. This study highlights the potential of the novel LEHSN as an oxygen carrier for pharmaceutical applications.
authors.affiliation: Department of Chemistry, Tongji University, 1239 Siping Road, Shanghai 200092, PR China.
authors.forename: Mingxian
authors.initials: M
authors.lastname: Liu
authors.forename: Lihua
authors.initials: L
authors.lastname: Gan
authors.forename: Liuhua
authors.initials: L
authors.lastname: Chen
authors.forename: Dazhang
authors.initials: D
authors.lastname: Zhu
authors.forename: Zijie
authors.initials: Z
authors.lastname: Xu
authors.forename: Zhixian
authors.initials: Z
authors.lastname: Hao
authors.forename: Longwu
authors.initials: L
authors.lastname: Chen
mesh_terms: D000327:Adsorption; D000818:Animals; D001802:Blood Substitutes / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002417:Cattle; D003102:Colloids; D003692:Delayed-Action Preparations; D004339:Drug Compounding; D004355:Drug Stability; D004655:Emulsions; D006454:Hemoglobins / Q000008:administration & dosage* / Q000493:pharmacokinetics; D054709:Lecithins / Q000737:chemistry; D008081:Liposomes; D008567:Membranes, Artificial; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles; D010100:Oxygen / Q000008:administration & dosage*; D010316:Particle Size; D012822:Silicon Dioxide; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D001802:Blood Substitutes; D003102:Colloids; D003692:Delayed-Action Preparations; D004655:Emulsions; D006454:Hemoglobins; D054709:Lecithins; D008081:Liposomes; D008567:Membranes, Artificial; D012822:Silicon Dioxide; D010100:Oxygen