title: Study of validity of pyridinoline and correlation of pyridinoline and beta crosslap in postmenopausal women.
abstract: This research studied the validity and correlation of beta-CTx (Betacrosslap) and Pyridinoline (PYD) in 71 cases of postmenopausal Thai women who attended at the osteoporosis clinic. The validity consisted of sensitivity, specificity and accuracy of PYD. They were 53.44, 84.6 and 59.15% respectively. So, the validity of pyridinoline test was rather poor and the correlation between betacrosslap and pyridinoline was weak (r = 0.123, p = 0.0001) which was not significant in practice. In conclusion, the pyridinoline test was not proper for bone resorption even pyridinoline was abundant in bone.
authors.affiliation: Department of Orthopaedic Surgery, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand. todrnarong@yahoo.com
authors.forename: Narong
authors.initials: N
authors.lastname: Bunyaratavej
authors.forename: Shutipen
authors.initials: S
authors.lastname: Buranasinsup
mesh_terms: D000596:Amino Acids / Q000097:blood*; D015415:Biomarkers / Q000097:blood*; D016723:Bone Remodeling / Q000502:physiology*; D003094:Collagen / Q000097:blood*; D005260:Female; D006801:Humans; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D012016:Reference Values; D015203:Reproducibility of Results
chemical_list: D000596:Amino Acids; D015415:Biomarkers; D010446:Peptide Fragments; C110762:glutamyl-lysyl-alanyl-histidyl-aspartyl-glycyl-glycyl-arginine; C015484:pyridinoline; D003094:Collagen