title: [Clinical features of drug-induced liver injury in children].
abstract: OBJECTIVE
  To study the clinical features of drug-induced liver injury in children.
  
  
  METHODS
  The clinical data of the hospitalized children with drug-induced liver injury over 5 years were retrospectively reviewed.
  
  
  RESULTS
  Of 641 cases of hospitalized children with liver injury, there were 64 cases (10%) of drug induced liver injury. Hepatocellular injury was the most common type of drug-induced liver injury (81%). The major drugs causing drug-induced liver injury included chemotherapy drugs, antibiotics and anti-tuberculosis drugs. Rash (16%), gastrointestinal reaction (15%), fever (14%) and liver intumescence (12%) were common clinical symptoms. A part of patients with drug-induced liver injury (11%) had no symptoms and signs.
  
  
  CONCLUSIONS
  Drug-induced liver injury is one of the common causes of liver damage in hospitalized children. Some children with drug-induced liver injury have no symptoms and signs. Hepatocellular injury is a major type of drug-induced liver injury in children, resulting less severe liver damage.
authors.affiliation: Department of Pediatrics, West China Second Hospital of Sichuan University, Chengdu, China.
authors.forename: Xin-Xin
authors.initials: XX
authors.lastname: Zhu
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhu
authors.forename: Chao-Min
authors.initials: CM
authors.lastname: Wan
mesh_terms: D000293:Adolescent; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis* / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012189:Retrospective Studies