title: Case report: grade 4 radiation-induced colitis following conventional reirradiation to a hip metastasis.
abstract: Palliative radiation therapy has been widely used for treatment of pain from metastatic bone disease. However, reirradiation is required in approximately 20% of patients initially treated with single fraction conventional palliative radiotherapy. There is a paucity of literature as to toxicities associated with reirradiation, and a lack of knowledge overall as to the cumulative dose limits for the organs at risk. We describe an uncommon late grade 4 adverse event of large bowel colitis in a patient initially radiated with 8 Gy in a single fraction, and reirradiated to the same area 3 months later with 20 Gy in 5 fractions due to pain progression.
authors.affiliation: Department of Radiation Oncology, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Giuseppina Laura
authors.initials: GL
authors.lastname: Masucci
authors.forename: Laurence
authors.initials: L
authors.lastname: Masson-Cote
authors.forename: Daniel
authors.initials: D
authors.lastname: Letourneau
authors.forename: Arjun
authors.initials: A
authors.lastname: Sahgal
mesh_terms: D001859:Bone Neoplasms / Q000532:radiotherapy* / Q000556:secondary; D001943:Breast Neoplasms / Q000473:pathology*; D003092:Colitis / Q000145:classification* / Q000209:etiology*; D005260:Female; D006621:Hip Joint; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy*; D011829:Radiation Dosage; D011832:Radiation Injuries; D011878:Radiotherapy / Q000009:adverse effects*