title: Magnesium, a drug of diverse use.
abstract: Magnesium has evolved as a drug with diverse clinical applications. Mg++ is an important caution and its homeostasis is very important for normal body functioning. The physiological role of Mg is due to its calcium channel blocking properties at smooth muscle, skeletal muscle and conduction system levels. The analgesic properties are due to NMDA receptor blocking action. Mg++ is beneficial in acute Myocardial Infarction, protection during open heart surgery and treatment and prevention of heart rhythm disturbances. Mg has an established role in the management of preeclampsia and eclampsia. Magnesium prevents or controls convulsions by blocking neuromuscular transmission and decreasing the release of acetylcholine at the motor nerve terminals. The use of MgSO4 in treating tetanus and acute asthma is established. In conclusion, Mg is a cost effective, widely used drug with multidisciplinary applications. Its majority of physiological effects are attributed to calcium channel blocking properties.
authors.affiliation: Department of Anaesthesia, Aga Khan University Hospital, Karachi.
authors.forename: Mohammad Irfan
authors.initials: MI
authors.lastname: Akhtar
authors.forename: Hameed
authors.initials: H
authors.lastname: Ullah
authors.forename: Mohammad
authors.initials: M
authors.lastname: Hamid
mesh_terms: D002121:Calcium Channel Blockers / Q000627:therapeutic use; D003362:Cost-Benefit Analysis; D019317:Evidence-Based Medicine; D006801:Humans; D053565:Hypercalciuria / Q000150:complications; D008274:Magnesium / Q000502:physiology / Q000627:therapeutic use*; D009397:Nephrocalcinosis / Q000150:complications; D015499:Renal Tubular Transport, Inborn Errors / Q000150:complications
chemical_list: D002121:Calcium Channel Blockers; D008274:Magnesium