title: Genome-wide integrative analysis revealed a correlation between lengths of copy number segments and corresponding gene expression profile.
abstract: Microarray analysis has been applied to comprehensively reveal the abnormalities of DNA copy number (CN) and gene expression in human cancer research during the last decade. These analyses have individually contributed to identify the genes associated with carcinogenesis, progression, metastasis of tumor cells and poor prognosis of cancer patients. However, it is known that the correlation between profiles of CN and gene expression does not highly correlate. Factors which determine the degree of correlation remain largely unexplained. To investigate one such factor, we performed trend analyses between the lengths of CN segments and corresponding gene expression profiles from microarray data in hepatocellular carcinoma (HCC) and colorectal carcinoma (CRC). Significant correlations were observed in CN gain of HCC and CRC (p<0.05). The trend of the CN loss showed a significant correlation in HCC although there was no correlation between the length of CN loss segments and gene expression in CRC. Our findings suggest that the influence of CN on gene expression highly depends on the length of CN region, especially in the case of CN gain. To the best of our knowledge, this is the first study describing the correlation between lengths of CNA segments and expression profiles of corresponding genes.
authors.forename: Ken
authors.initials: K
authors.lastname: Miyaguchi
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Fukuoka
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mizushima
authors.forename: Mahmut
authors.initials: M
authors.lastname: Yasen
authors.forename: Shota
authors.initials: S
authors.lastname: Nemoto
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Ishikawa
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Uetake
authors.forename: Shinji
authors.initials: S
authors.lastname: Tanaka
authors.forename: Kenichi
authors.initials: K
authors.lastname: Sugihara
authors.forename: Shigeki
authors.initials: S
authors.lastname: Arii
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tanaka