title: A water-soluble polycarbonate with dimethylamino pendant groups prepared by enzyme-catalyzed ring-opening polymerization.
abstract: A water-soluble polycarbonate with dimethylamino pendant groups, poly(2-dimethylaminotrimethylene carbonate) (PDMATC), is synthesized and characterized. First, the six-membered carbonate monomer, 2-dimethylaminotrimethylene carbonate (DMATC), is prepared via the cyclization reaction of 2-(dimethylamino)propane-1,3-diol with triphosgene in the presence of triethylamine. Although the attempted ring-opening polymerization (ROP) of DMATC with Sn(Oct)(2)  as a catalyst fails, the ROP of DMATC is successfully carried out with Novozym-435 as a catalyst to give water-soluble aliphatic polycarbonate PDMATC with low cytotoxicity and good degradability.
authors.affiliation: Key Laboratory of Biomedical Polymers of Ministry of Education, Department of Chemistry, Wuhan University, Wuhan 430072, PR China.
authors.forename: Xiaojin
authors.initials: X
authors.lastname: Zhang
authors.forename: Mengmeng
authors.initials: M
authors.lastname: Cai
authors.forename: Zhenlin
authors.initials: Z
authors.lastname: Zhong
authors.forename: Renxi
authors.initials: R
authors.lastname: Zhuo
mesh_terms: D000818:Animals; D055162:Biocatalysis; D019556:COS Cells; D002470:Cell Survival / Q000187:drug effects; D002522:Chlorocebus aethiops; D003500:Cyclization; D006367:HeLa Cells; D006801:Humans; D008049:Lipase / Q000378:metabolism*; D011076:Polycarboxylate Cement / Q000737:chemistry*; D011091:Polyesters / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D058105:Polymerization; D011412:Propanolamines; D011409:Propylene Glycols / Q000737:chemistry; D014867:Water / Q000737:chemistry*
chemical_list: D011076:Polycarboxylate Cement; D011091:Polyesters; D011412:Propanolamines; D011409:Propylene Glycols; D014867:Water; C005506:polycarbonate; D008049:Lipase; C072422:serinol