title: [Assessments of progression in non-muscle-invasive bladder cancer].
abstract: We retrospectively studied 463 patients with primary non-muscle-invasive bladder cancer diagnosed between 1999 and 2008 at two facilities (Kawasaki Municipal Ida Hospital and Yokohama Minami Kyosai Hospital). In this study, disease progression was defined as invasion to the muscle or further (upstage) and presence of metastasis (metastasis). We detected progression in 22 cases, including 18 upstages and 4 metastasis. Univariate analysis showed that factors associated with progression were T category (pT1 p< 0.0001), grade (high grade p< 0.0001, G3 p< 0.0001) and number of tumors (multiple p=0.0213). Multivariate analysis showed that the only equivocal factor associated with progression was T category (T1). Use of a second tansurethral resection for high-grade pT1 cases was unrelated to progression. Among the patients with progression, many had a more advanced T category at the time of radical treatment, and the results of treatment were poor. The factors associated with progression of bladder cancer should be investigated in more detail, so that early radical treatment can be initiated in eligible patients.
authors.affiliation: The Department of Urology, Kawasaki Municipal Ida Hospital.
authors.forename: Kotaro
authors.initials: K
authors.lastname: Suzuki
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Nohda
authors.forename: Makoto
authors.initials: M
authors.lastname: Funahashi
authors.forename: Kimio
authors.initials: K
authors.lastname: Chiba
authors.forename: Toshihito
authors.initials: T
authors.lastname: Shinagawa
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Mizuno
authors.forename: Naoya
authors.initials: N
authors.lastname: Fujikawa
authors.forename: Takayuki
authors.initials: T
authors.lastname: Murakami
authors.forename: Ichiro
authors.initials: I
authors.lastname: Ikeda
authors.forename: Naomi
authors.initials: N
authors.lastname: Kono
mesh_terms: D018450:Disease Progression; D006801:Humans; D009132:Muscles / Q000473:pathology; D009361:Neoplasm Invasiveness; D011379:Prognosis; D012189:Retrospective Studies; D001749:Urinary Bladder Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery