title: Decreased Phosphorylation and Increased Methionine Oxidation of α-Synuclein in the Methionine Sulfoxide Reductase A Knockout Mouse.
abstract: Previously, we have showed that overexpression of methionine-oxidized α-synuclein in methionine sulfoxide reductase A (MsrA) null mutant yeast cells inhibits α-synuclein phosphorylation and increases protein fibrillation. The current studies show that ablation of mouse MsrA gene caused enhanced methionine oxidation of α-synuclein while reducing its own phophorylation levels, especially in the hydrophobic cell-extracted fraction. These data provide supportive evidence that a compromised MsrA function in mammalian brain may cause enhanced pathologies associated with altered α-synuclein oxidation and phosphorylation levels.
authors.affiliation: Department of Pharmacology and Toxicology, School of Pharmacy, The University of Kansas, Lawrence, KS 66045, USA.
authors.forename: Derek B
authors.initials: DB
authors.lastname: Oien
authors.forename: Gonzalo A
authors.initials: GA
authors.lastname: Carrasco
authors.forename: Jackob
authors.initials: J
authors.lastname: Moskovitz