title: Genomic methods for clinical and translational pain research.
abstract: Pain is a complex sensory experience for which the molecular mechanisms are yet to be fully elucidated. Individual differences in pain sensitivity are mediated by a complex network of multiple gene polymorphisms, physiological and psychological processes, and environmental factors. Here, we present the methods for applying unbiased molecular-genetic approaches, genome-wide association study (GWAS), and global gene expression analysis, to help better understand the molecular basis of pain sensitivity in humans and variable responses to analgesic drugs.
authors.affiliation: National Institute of Nursing Research, National Institutes of Health, Bethesda, MD, USA.
authors.forename: Dan
authors.initials: D
authors.lastname: Wang
authors.forename: Hyungsuk
authors.initials: H
authors.lastname: Kim
authors.forename: Xiao-Min
authors.initials: XM
authors.lastname: Wang
authors.forename: Raymond
authors.initials: R
authors.lastname: Dionne
mesh_terms: D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study / Q000379:methods*; D023281:Genomics; D006801:Humans; D010146:Pain / Q000235:genetics* / Q000378:metabolism; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide