title: Family history and APOE-4 genetic risk in Alzheimer's disease.
abstract: Identifying risk factors for Alzheimer's disease, such as carrying the APOE-4 allele, and understanding their contributions to disease pathophysiology or clinical presentation is critical for establishing and improving diagnostic and therapeutic strategies. A first-degree family history of Alzheimer's disease represents a composite risk factor, which reflects the influence of known and unknown susceptibility genes and perhaps non-genetic risks. There is emerging evidence that investigating family history risk associated effects may contribute to advances in Alzheimer's disease research and ultimately clinical practice.
authors.affiliation: Department of Psychiatry and Psychotherapy, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany. markus.donix@uniklinikum-dresden.de
authors.forename: Markus
authors.initials: M
authors.lastname: Donix
authors.forename: Gary W
authors.initials: GW
authors.lastname: Small
authors.forename: Susan Y
authors.initials: SY
authors.lastname: Bookheimer
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics* / Q000473:pathology / Q000503:physiopathology; D053327:Apolipoprotein E4 / Q000235:genetics* / Q000502:physiology; D015415:Biomarkers / Q000134:cerebrospinal fluid; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D056324:Diffusion Tensor Imaging; D005190:Family; D059907:Functional Neuroimaging; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D008279:Magnetic Resonance Imaging; D059906:Neuroimaging; D010641:Phenotype; D049268:Positron-Emission Tomography; D012307:Risk Factors
chemical_list: D053327:Apolipoprotein E4; D015415:Biomarkers