title: Interference of intrinsic curvature of DNA by DNA-intercalating agents.
abstract: It has been demonstrated in our studies that the intrinsic curvature of DNA can be easily interrupted by low concentrations of chloroquine and ethidium bromide. In addition, the changes of DNA curvature caused by varying the concentration of these two DNA intercalators can be readily verified through using an atomic force microscope.
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, 21 Nanyang Link, Singapore 637371.
authors.forename: Hong Kee
authors.initials: HK
authors.lastname: Tan
authors.forename: Dawei
authors.initials: D
authors.lastname: Li
authors.forename: Robert Kenneth
authors.initials: RK
authors.lastname: Gray
authors.forename: Zhaoqi
authors.initials: Z
authors.lastname: Yang
authors.forename: Magdeline Tao Tao
authors.initials: MT
authors.lastname: Ng
authors.forename: Hao
authors.initials: H
authors.lastname: Zhang
authors.forename: Joel Ming Rui
authors.initials: JM
authors.lastname: Tan
authors.forename: Shu Hui
authors.initials: SH
authors.lastname: Hiew
authors.forename: Jasmine Yiqin
authors.initials: JY
authors.lastname: Lee
authors.forename: Tianhu
authors.initials: T
authors.lastname: Li
mesh_terms: D004247:DNA / Q000737:chemistry / Q000648:ultrastructure*; D004996:Ethidium / Q000737:chemistry; D018625:Microscopy, Atomic Force; D010957:Plasmids / Q000737:chemistry / Q000648:ultrastructure*
chemical_list: D004247:DNA; D004996:Ethidium