title: Bilateral uveal metastasis of a subcutaneous fibrosarcoma in a cat.
abstract: A 6-year-old neutered male domestic short-haired cat was presented to the Comparative Ophthalmology service at Michigan State University with a 3-week history of decreased appetite and redness of the left eye. The left forelimb had been removed 15 months previously because of the presence of a subcutaneous fibrosarcoma. In the left globe, a large iridal mass was associated with increased intraocular pressure and retinal detachment. A smaller mass involving the right iris was also present. Imaging revealed a 2-cm mass in the left caudodorsal lung lobe, and abdominal ultrasound showed multifocal bilateral renal masses. Aspirates of these masses were nondiagnostic. The left globe was removed for palliative reasons, and histopathology showed that fibrosarcoma was infiltrating the iris, choroid, and optic nerve. Despite systemic chemotherapy with doxorubicin, the animal died 4 months after initial presentation. Histopathology confirmed highly angioinvasive metastatic fibrosarcoma also in the right uveal tract, the lungs, and both kidneys.
authors.affiliation: Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, USA. mowat@cvm.msu.edu
authors.forename: Freya M
authors.initials: FM
authors.lastname: Mowat
authors.forename: Ingeborg M
authors.initials: IM
authors.lastname: Langohr
authors.forename: Olenka
authors.initials: O
authors.lastname: Bilyk
authors.forename: Amy
authors.initials: A
authors.lastname: Koterbay
authors.forename: Kenneth E
authors.initials: KE
authors.lastname: Pierce
authors.forename: Simon M
authors.initials: SM
authors.lastname: Petersen-Jones
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002371:Cat Diseases / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D002415:Cats; D004317:Doxorubicin / Q000627:therapeutic use; D017809:Fatal Outcome; D005354:Fibrosarcoma / Q000188:drug therapy / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D008297:Male; D012983:Soft Tissue Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D014604:Uveal Neoplasms / Q000188:drug therapy / Q000556:secondary / Q000601:surgery / Q000662:veterinary*
chemical_list: D000970:Antineoplastic Agents; D004317:Doxorubicin