title: MicroRNAs in patients on chronic hemodialysis (MINOS study).
abstract: OBJECTIVE
  Diagnosis of acute myocardial injury with biomarkers is difficult in patients with advanced renal failure. Circulating microRNAs are promising new biomarkers of myocardial injury. It is unknown whether levels of microRNAs are affected in patients undergoing hemodialysis.
  
  
  METHODS
  High-sensitivity cardiac troponin T (hsTnT) and cardiac-enriched miR-499 were measured in 41 patients with ESRD undergoing hemodialysis and 41 controls.
  
  
  RESULTS
  Levels of hsTnT and miR-499 were highly elevated in patients with ESRD compared with controls (>80-fold increase; P<0.001). Among patients with ESRD, 98% had positive hsTnT levels and 46% had positive miR-499 levels. Levels of troponins were not affected by hemodialysis. However, miR-499 levels were decreased after hemodialysis (6.5-fold decrease; P=0.002).
  
  
  CONCLUSIONS
  Both miR-499 and troponins are elevated in patients with advanced renal failure. However, whereas levels of troponins are unaffected by hemodialysis, this is not the case for miR-499. Therefore, these observations mitigate the potential of miR-499 as a marker of myocardial injury in patients with ESRD.
authors.affiliation: Division of Cardiology, Centre Hospitalier, Luxembourg, Luxembourg.
authors.forename: Cristina
authors.initials: C
authors.lastname: Emilian
authors.forename: Emeline
authors.initials: E
authors.lastname: Goretti
authors.forename: Fernand
authors.initials: F
authors.lastname: Prospert
authors.forename: Dominique
authors.initials: D
authors.lastname: Pouthier
authors.forename: Pierre
authors.initials: P
authors.lastname: Duhoux
authors.forename: Georges
authors.initials: G
authors.lastname: Gilson
authors.forename: Yvan
authors.initials: Y
authors.lastname: Devaux
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Wagner
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D006331:Heart Diseases / Q000097:blood / Q000175:diagnosis / Q000209:etiology / Q000235:genetics*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications / Q000628:therapy*; D008189:Luxembourg; D008297:Male; D035683:MicroRNAs / Q000097:blood*; D008875:Middle Aged; D011237:Predictive Value of Tests; D006435:Renal Dialysis / Q000009:adverse effects; D015203:Reproducibility of Results; D013997:Time Factors; D020107:Troponin T / Q000097:blood
chemical_list: D015415:Biomarkers; C548683:MIRN499 microRNA, human; D035683:MicroRNAs; D020107:Troponin T