title: Hematological: Low all-cause mortality and low occurrence of antimicrobial resistance in hematological patients with bacteremia receiving no antibacterial prophylaxis: a single-center study.
abstract: BACKGROUND
  Bacteremia is a major cause of morbidity and mortality in patients with hematological malignancies.
  
  
  OBJECTIVE
  The aim of this study was to define temporal trends in species distribution, antimicrobial susceptibility, and all-cause mortality in bacteremic hospitalized patients receiving no antibacterial prophylaxis during chemotherapy-induced neutropenia.
  
  
  METHODS
  A total of 677 clinical episodes of bacteremia were identified in 463 patients during 2002-2008, and the results were compared with those published from the same institution during 1980-86 and 1988-2001. No major changes in patient selection were introduced during this period.
  
  
  RESULTS
  Between 2002 and 2008, the dominating pathogens were Escherichia coli (18%), coagulase-negative staphylococci (15%), viridans streptococci (14%), Klebsiella spp. (10%), and Enterococcus faecium (8%). The 7-d crude mortality rate was 5.2%. Polymicrobial bacteremia was seen in 25.7% of the patients who died within 7 d and in 13.1% of the survivors (P = 0.04). Acquired resistance was rarely observed, but a statistically significant increase in ciprofloxacin resistance in E. coli was observed. Comparing 2002-2008 with historical data from the same institution, the proportion of Gram-positive isolates remained stable at 53-55% from 1988.
  
  
  CONCLUSIONS
  The avoidance of fluoroquinolone prophylaxis may have contributed to a stable proportion of Gram-positive bacteremia. The crude mortality was low in an international perspective. Acquired resistance was uncommon, but ciprofloxacin resistance in E. coli increased significantly. We believe that an indiscriminate use of antibacterial prophylaxis could be avoided in neutropenic patients without a negative impact on mortality.
authors.affiliation: Department of Medicine, Karolinska Institutet, Karolinska University Hospital Solna, Stockholm, Sweden. christian.kjellander@karolinska.se
authors.forename: Christian
authors.initials: C
authors.lastname: Kjellander
authors.forename: Magnus
authors.initials: M
authors.lastname: Björkholm
authors.forename: Honar
authors.initials: H
authors.lastname: Cherif
authors.forename: Mats
authors.initials: M
authors.lastname: Kalin
authors.forename: Christian G
authors.initials: CG
authors.lastname: Giske
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis; D016470:Bacteremia / Q000188:drug therapy*; D002423:Cause of Death; D024881:Drug Resistance, Bacterial; D006801:Humans
chemical_list: D000900:Anti-Bacterial Agents