title: Memory enhancement: consolidation, reconsolidation and insulin-like growth factor 2.
abstract: Life and societies would change significantly if memory capacity or persistence in health and disease could be enhanced. It has been known for many years that memory can be improved and strengthened. Substances known to enhance memory include hormones, neurotransmitters, neuropeptides and metabolic substrates. Recently, attention has been given to identifying the molecular mechanisms and targets whereby memory enhancement can be achieved. One approach would be to target the physiological changes that are induced by learning and naturally required for memory strengthening via consolidation and reconsolidation. Here, we review approaches that boost memories by targeting the cAMP response element binding protein-CCAAT enhancer binding protein (CREB-C/EBP) pathway and/or its recently identified target gene insulin-like growth factor 2 (IGF2).
authors.affiliation: Center for Neural Science, New York University, New York, NY 10003, USA. ca60@nyu.edu
authors.forename: Cristina M
authors.initials: CM
authors.lastname: Alberini
authors.forename: Dillon Y
authors.initials: DY
authors.lastname: Chen
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology*; D022762:CCAAT-Enhancer-Binding Proteins / Q000378:metabolism; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism; D006801:Humans; D007335:Insulin-Like Growth Factor II / Q000378:metabolism*; D008568:Memory / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D022762:CCAAT-Enhancer-Binding Proteins; D017362:Cyclic AMP Response Element-Binding Protein; D007335:Insulin-Like Growth Factor II