title: CD33-related siglecs as potential modulators of inflammatory responses.
abstract: The immune system must be tightly regulated to prevent unwanted tissue damage caused by exaggerated immune and inflammatory reactions. Inhibitory and activating immune receptors play a crucial role in this function via phosphotyrosine-dependent signaling pathways. A significant body of evidence has accumulated suggesting that the siglec family of sialic acid binding Ig-like lectins makes an important contribution to this immunoregulation. The CD33-related siglecs are a distinct subset of inhibitory and activating receptors, expressed primarily on leukocytes in a cell type-specific manner. Here, we critically assess the in vitro and in vivo evidence on the functional role for CD33-related siglecs in modulation of inflammatory and immune responses.
authors.affiliation: Division of Cell Signaling and Immunology, College of Life Sciences, University of Dundee, United Kingdom. p.r.crocker@dundee.ac.uk
authors.forename: Paul R
authors.initials: PR
authors.lastname: Crocker
authors.forename: Sarah J
authors.initials: SJ
authors.lastname: McMillan
authors.forename: Hannah E
authors.initials: HE
authors.lastname: Richards
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000276:immunology*; D015214:Antigens, Differentiation, Myelomonocytic / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology; D054884:Host-Pathogen Interactions / Q000276:immunology; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000276:immunology*; D018836:Inflammation Mediators / Q000276:immunology; D037102:Lectins / Q000276:immunology*; D007962:Leukocytes / Q000276:immunology; D051379:Mice; D018448:Models, Immunological; D019636:Neurodegenerative Diseases / Q000276:immunology; D063268:Sialic Acid Binding Ig-like Lectin 3; D063265:Sialic Acid Binding Immunoglobulin-like Lectins; D015398:Signal Transduction / Q000276:immunology
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D001324:Autoantigens; C571163:CD33 protein, human; C571165:Cd33 protein, mouse; D018836:Inflammation Mediators; D037102:Lectins; D063268:Sialic Acid Binding Ig-like Lectin 3; D063265:Sialic Acid Binding Immunoglobulin-like Lectins