title: [Comparison of gene expression between naturally occurring and diet-induced T2DM in cynomolgus monkeys].
abstract: To explore pathological alteration of T2DM in cynomolgus monkeys, gene expression profiles of peripheral blood leukocytes from spontaneous and diet-induced T2DM models  was analyzed using quantitative real-time PCR. Among 36 T2DM associated genes tested, 19 genes (including G6PC, CCR2B, CTLA4) displayed a similar expression pattern in both spontaneous and diet-induced T2DM models and were significantly up-regulated or down-regulated compared to controls. Interestingly, expression abundance of all up-regulated genes in the diet-induced T2DM was stronger, although not significantly, than spontaneous models, indicating diet-induced T2DM in monkeys should be a reliable research model for changes in gene expression. The characteristic gene expression pattern obtained here may be useful for the clinical diagnosis of T2DM.
authors.affiliation: Guangdong Entomological Institute, Guangzhou, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Ji
authors.forename: Li-Sha
authors.initials: LS
authors.lastname: Jin
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Zeng
authors.forename: Xiu-Juan
authors.initials: XJ
authors.lastname: Zhang
authors.forename: Yan-Chun
authors.initials: YC
authors.lastname: Zhang
authors.forename: Yun-Xiao
authors.initials: YX
authors.lastname: Sun
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Gao
authors.forename: Hong
authors.initials: H
authors.lastname: He
authors.forename: Jun-Hua
authors.initials: JH
authors.lastname: Rao
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Liu
authors.forename: Bai-Lu
authors.initials: BL
authors.lastname: Peng
mesh_terms: D000818:Animals; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology / Q000235:genetics* / Q000378:metabolism*; D059305:Diet, High-Fat / Q000009:adverse effects*; D004041:Dietary Fats / Q000009:adverse effects* / Q000378:metabolism; D004195:Disease Models, Animal; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D006801:Humans; D008252:Macaca fascicularis / Q000235:genetics / Q000378:metabolism
chemical_list: D004041:Dietary Fats