title: Cut off values for abdominal obesity as a criterion of metabolic syndrome in an ethnic Kyrgyz population (Central Asian region).
abstract: BACKGROUND
  People of different racial and ethnic backgrounds have a distinct pattern of central fat deposition, thus making it necessary to devise a race based approach for the diagnosis and evaluation of abdominal obesity (AO). This is the first study to determine the optimal waist circumference (WC) cutoff values for definition of AO in an ethnic Kyrgyz population.
  
  
  METHODS
  323 persons of Kyrgyz ethnicity (183 women and 140 men), with a mean age of 51.8 ± 9.5 years old were included in the study. Measurement of blood pressure (BP), anthropometric data (including body mass index calculation and WC measurement), fasting blood sugar, serum lipid parameters and insulin were performed in all examined individuals. Insulin resistance (IR) was considered as HOMA index (insulin × fasting glucose/22.5) ≥ 2.77. Sensitivity and specificity for the presence of IR or two other criteria of MS (according to the international classification, 2009) were calculated by using receiver operating characteristic (ROC) curves for men and women separately.
  
  
  RESULTS
  The optimal sensitivity and specificity obtained from the ROC curves for IR were 88 cm in women (sensitivity of 0.85, 95%CI (0.72-0.93), specificity of 0.58, 95%CI (0.49-0.66)) and 94 cm for men (sensitivity of 0.8, 95% CI (0.65-0.91), specificity of 0.61, 95% CI (0.51-0.71)). The data from the ROC curve for any two other MS criteria confirmed the results and the WC 88 cm in women (sensitivity of 0.82, 95% CI (0.72-0.9), specificity of 0.72, 95% CI (0.62-0.8)) and 94 cm in men (sensitivity of 0.74, 95% CI (0.62-0.84), specificity of 0.73, 95% CI (0.61-0.83)) were corresponded to the optimal sensitivity and specificity.
  
  
  CONCLUSIONS
  WC ≥ 88 cm and ≥ 94 cm should be used as a criterion for the diagnosis of AO for Kyrgyz women and men respectively based on these results.
authors.affiliation: Kyrgyz State Medical Academy, Akhunbaev street 92, Bishkek 720020, Kyrgyzstan. amirrakhimov1@gmail.com
authors.forename: Aibek E
authors.initials: AE
authors.lastname: Mirrakhimov
authors.forename: Olga S
authors.initials: OS
authors.lastname: Lunegova
authors.forename: Alina S
authors.initials: AS
authors.lastname: Kerimkulova
authors.forename: Cholpon B
authors.initials: CB
authors.lastname: Moldokeeva
authors.forename: Malik P
authors.initials: MP
authors.lastname: Nabiev
authors.forename: Erkin M
authors.initials: EM
authors.lastname: Mirrakhimov
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000208:ethnology / Q000502:physiology; D007707:Kyrgyzstan; D008297:Male; D024821:Metabolic Syndrome / Q000175:diagnosis* / Q000208:ethnology* / Q000503:physiopathology; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000175:diagnosis* / Q000208:ethnology* / Q000503:physiopathology; D018579:Patient Selection; D012372:ROC Curve; D012680:Sensitivity and Specificity; D055105:Waist Circumference / Q000502:physiology