title: Laboratory-based surveillance of non-typhoidal Salmonella infections in Guangdong Province, China.
abstract: Salmonella is one of the most common foodborne pathogens in humans. Laboratory-based surveillance for non-typhoidal Salmonella infection was conducted in Guangdong Province, China to improve understanding about the disease burden and detection of dispersed outbreaks. Salmonella isolated from patients with diarrhea were sent from 16 sentinel hospitals to local public health laboratories for confirmation, serotyping, antimicrobial susceptibility testing, and pulsed-field gel electrophoresis (PFGE). PFGE patterns were analyzed to identify clusters representing potential outbreaks. Between September 2009 and October 2010, 352 (4%) Salmonella isolates were obtained from 9167 stool specimens. Salmonella enterica serotype Typhimurium (45%) and Salmonella enterica serotype Enteritidis (13%) were the most common serotypes, and multidrug resistance was high, especially in Salmonella Typhimurium isolates. PFGE patterns of obtained Salmonella isolates were found to be diverse, but a unique PFGE pattern comprising 53 Salmonella Typhimurium isolates were found to occur almost exclusively in infants. Epidemiologic studies are ongoing to determine whether a common exposure is the source of the Salmonella Typhimurium strain frequently isolated from infants.
authors.affiliation: Guangdong Provincial Center for Disease Control and Prevention, No. 176 Xingang West Road, Guangzhou, Guangdong Province, People's Republic of China.
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Deng
authors.forename: Lu
authors.initials: L
authors.lastname: Ran
authors.forename: Shuyu
authors.initials: S
authors.lastname: Wu
authors.forename: Bixia
authors.initials: B
authors.lastname: Ke
authors.forename: Dongmei
authors.initials: D
authors.lastname: He
authors.forename: Xingfen
authors.initials: X
authors.lastname: Yang
authors.forename: Yonghui
authors.initials: Y
authors.lastname: Zhang
authors.forename: Changwen
authors.initials: C
authors.lastname: Ke
authors.forename: John D
authors.initials: JD
authors.lastname: Klena
authors.forename: Meiying
authors.initials: M
authors.lastname: Yan
authors.forename: Zijian
authors.initials: Z
authors.lastname: Feng
authors.forename: Biao
authors.initials: B
authors.lastname: Kan
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.forename: Matthew
authors.initials: M
authors.lastname: Mikoleit
authors.forename: Jay K
authors.initials: JK
authors.lastname: Varma
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D003967:Diarrhea / Q000453:epidemiology* / Q000382:microbiology; D004196:Disease Outbreaks; D016521:Electrophoresis, Gel, Pulsed-Field; D005243:Feces / Q000382:microbiology; D005260:Female; D005517:Foodborne Diseases / Q000453:epidemiology* / Q000382:microbiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D011634:Public Health; D012480:Salmonella Infections / Q000453:epidemiology* / Q000382:microbiology; D019779:Salmonella enterica / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification*; D012477:Salmonella enteritidis / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification; D012486:Salmonella typhimurium / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification; D012703:Serotyping; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents