title: Molecular allergology in practice: an unusual case of LTP allergy.
abstract: The authors describe an unusual case of LTP allergy. A 35 years old patient presented repeated episodes of angiooedema after food intake and complained 10 years ago of contact urticaria and rhinoconjunctivitis when exposed to cannabis leaves and to marijuana smoke. The suspected responsible foods, such as wheat flour in bread, are known to contain LTR Oral syndrome occurred after ingestion of walnuts. Cutaneous tests confirmed immediate responses to several flours and nuts and also to cannabis leaf and flower. A few months later he had similar accidents following peach ingestion and drinking of beer and several wines which all induced positive skin tests. Serological investigations using ImmunoCAP and ISAC microarray confirmed IgE positivity for n Pru p3, r Cor a 8 and n Art v3. It was assumed that sensitization to LTP, the major allergen of cannabis, was responsible of the primary sensitization and induced further LTP food allergies.
authors.affiliation: Division of Asthma and Allergy, Department of Chest Diseases, University Hospital, Strasbourg, France. Carine.Favre-Metz@chru-strasbourg.fr
authors.forename: C
authors.initials: C
authors.lastname: Metz-Favre
authors.forename: G
authors.initials: G
authors.lastname: Pauli
authors.forename: J C
authors.initials: JC
authors.lastname: Bessot
authors.forename: F
authors.initials: F
authors.lastname: De Blay
mesh_terms: D000328:Adult; D052179:Antigens, Plant / Q000009:adverse effects / Q000276:immunology* / Q000378:metabolism; D001939:Bread / Q000009:adverse effects; D002186:Cannabinoids / Q000009:adverse effects / Q000276:immunology; D002188:Cannabis; D002352:Carrier Proteins / Q000009:adverse effects / Q000276:immunology* / Q000378:metabolism; D003429:Cross Reactions; D003877:Dermatitis, Contact / Q000150:complications / Q000175:diagnosis* / Q000276:immunology / Q000503:physiopathology; D005433:Flour / Q000009:adverse effects; D005512:Food Hypersensitivity / Q000150:complications / Q000175:diagnosis* / Q000276:immunology / Q000503:physiopathology; D006801:Humans; D031324:Juglans / Q000009:adverse effects; D008297:Male; D008385:Marijuana Smoking / Q000009:adverse effects; D010940:Plant Proteins / Q000009:adverse effects / Q000276:immunology* / Q000378:metabolism; D012882:Skin Tests
chemical_list: D052179:Antigens, Plant; D002186:Cannabinoids; D002352:Carrier Proteins; D010940:Plant Proteins; C511920:lipid transfer proteins, plant