title: Efficient transmission of pandemic H1N1 influenza viruses with high-level oseltamivir resistance.
abstract: The limited availability of approved influenza virus antivirals highlights the importance of studying the fitness and transmissibility of drug-resistant viruses. S247N is a novel, naturally occurring N1 neuraminidase mutation that reduces oseltamivir sensitivity and greatly potentiates oseltamivir resistance in the context of the H275Y mutation. Here we show that highly oseltamivir-resistant viruses containing both the S247N and H275Y mutations transmit efficiently in the guinea pig transmission model.
authors.affiliation: Department of Microbiology, Mount Sinai School of Medicine, New York, New York, USA.
authors.forename: Christopher W
authors.initials: CW
authors.lastname: Seibert
authors.forename: Saad
authors.initials: S
authors.lastname: Rahmat
authors.forename: Florian
authors.initials: F
authors.lastname: Krammer
authors.forename: Peter
authors.initials: P
authors.lastname: Palese
authors.forename: Nicole M
authors.initials: NM
authors.lastname: Bouvier
mesh_terms: D019943:Amino Acid Substitution; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D004285:Dogs; D024882:Drug Resistance, Viral / Q000235:genetics; D006168:Guinea Pigs; D053118:Influenza A Virus, H1N1 Subtype / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics*; D009154:Mutation; D009439:Neuraminidase / Q000235:genetics / Q000378:metabolism; D009976:Orthomyxoviridae Infections / Q000635:transmission*; D053139:Oseltamivir / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D053139:Oseltamivir; D009439:Neuraminidase