title: New thymine-based derivative of nitrogen mustards.
abstract: This work deals with the synthesis of a new nitrogen mustard derivative based on thymine. To introduce the bis(2-chloroethyl)amine group to position 4 of the pyrimidine base, many strategies were explored and the desired compound was finally obtained, thanks to a synthetic pathway in five steps.
authors.affiliation: Laboratoire de Chimie des Substances Naturelles EA1069, Faculté des Sciences et Techniques, Limoges, France.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Boëns
authors.forename: Karine
authors.initials: K
authors.lastname: Teste
authors.forename: Amel
authors.initials: A
authors.lastname: Hadj-Bouazza
authors.forename: Jihane
authors.initials: J
authors.lastname: Ismaili
authors.forename: Rachida
authors.initials: R
authors.lastname: Zerrouki
mesh_terms: D000478:Alkylation; D018906:Antineoplastic Agents, Alkylating / Q000138:chemical synthesis* / Q000737:chemistry; D004983:Ethanolamines / Q000737:chemistry; D008466:Mechlorethamine / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013941:Thymine / Q000737:chemistry*
chemical_list: D018906:Antineoplastic Agents, Alkylating; D004983:Ethanolamines; D008466:Mechlorethamine; C020283:diethanolamine; D013941:Thymine