title: Alzheimer's disease is associated with a low prevalence of hypertension.
abstract: OBJECTIVE
  Dementia is one of the most common health problems in the world. Alzheimer's disease (AD) is the most common form of dementia. The relation between blood pressure (BP) and dementia has been the subject of numerous epidemiological studies, and midlife hypertension (HT) is a risk factor for AD. The association between BP and risk of dementia is lower in the older population. The aim of this study was to examine the association between the prevalence of HT and AD in elderly individuals.
  
  
  METHODS
  In this cross-sectional study, 193 patients with AD and 1,860 patients with normal cognitive function were evaluated.
  
  
  RESULTS
  The prevalence of HT was lower in the AD group (60.6 vs. 70.5%; p = 0.005). In multivariate analysis, AD was found to be negatively correlated with HT (OR = 0.649; 95% CI 0.461-0.916).
  
  
  CONCLUSIONS
  The prevalence of HT was lower in patients with AD compared to subjects without AD. Physicians who deal with AD patients must keep in mind that the need for antihypertensive medication may decline during the dementia process.
authors.affiliation: Division of Geriatric Medicine, Hacettepe University, Ankara, Turkey. mekuyumcu@gmail.com
authors.forename: Mehmet Emin
authors.initials: ME
authors.lastname: Kuyumcu
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Yesil
authors.forename: Zeynel Abidin
authors.initials: ZA
authors.lastname: Oztürk
authors.forename: Meltem
authors.initials: M
authors.lastname: Halil
authors.forename: Zekeriya
authors.initials: Z
authors.lastname: Ulger
authors.forename: Burcu Balam
authors.initials: BB
authors.lastname: Yavuz
authors.forename: Mustafa
authors.initials: M
authors.lastname: Cankurtaran
authors.forename: Esat
authors.initials: E
authors.lastname: Cınar
authors.forename: Servet
authors.initials: S
authors.lastname: Arıoğul
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000453:epidemiology*; D000704:Analysis of Variance; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001772:Blood Cell Count; D001774:Blood Chemical Analysis; D001794:Blood Pressure / Q000502:physiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000453:epidemiology*; D008055:Lipids / Q000097:blood; D008297:Male; D009483:Neuropsychological Tests; D012044:Regression Analysis; D012307:Risk Factors
chemical_list: D000959:Antihypertensive Agents; D008055:Lipids