title: Collagen XIII: a type II transmembrane protein with relevance to musculoskeletal tissues, microvessels and inflammation.
abstract: Collagen XIII and the homologous collagens XXIII and XXV form a subgroup of type II transmembrane proteins within the collagen superfamily. Collagen XIII consists of a short cytosolic domain, a transmembrane domain and a large extracellular ectodomain, which may be shed into the pericellular matrix. It has been proposed that collagen XIII may function as an adhesion molecule, due to its cellular localization at focal contacts, numerous interactions with basement membrane (BM) and other extracellular matrix (ECM) proteins and expression at various cell-cell and cell-matrix junctions. Recent in vivo studies highlight its involvement in the development, differentiation and maturation of musculoskeletal tissues and vessels and in maintaining tissue integrity.
authors.affiliation: Center for Cell-Matrix Research and Biocenter Oulu, Department of Medical Biochemistry and Molecular Biology, PO Box 5000, 90014 University of Oulu, Finland. anne.heikkinen@oulu.fi
authors.forename: Anne
authors.initials: A
authors.lastname: Heikkinen
authors.forename: Hongmin
authors.initials: H
authors.lastname: Tu
authors.forename: Taina
authors.initials: T
authors.lastname: Pihlajaniemi
mesh_terms: D000818:Animals; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000378:metabolism; D024181:Collagen Type XIII / Q000235:genetics / Q000378:metabolism*; D022001:Focal Adhesions / Q000378:metabolism*; D015870:Gene Expression; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000378:metabolism*; D051379:Mice; D055806:Microvessels / Q000378:metabolism; D009141:Musculoskeletal System / Q000378:metabolism; D009469:Neuromuscular Junction / Q000378:metabolism; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D017434:Protein Structure, Tertiary
chemical_list: D015815:Cell Adhesion Molecules; D024181:Collagen Type XIII; D020033:Protein Isoforms