title: Assessment of efficacy and adverse effects of trazodone in the treatment of major depressive disorder.
abstract: BACKGROUND
  Major depressive disorder is a serious and disabling illness in the world and is common chronic and recurrent disorder. It is the fourth most important cause of worldwide loss in disability.
  
  
  METHODS
  This was prospective and open-label study, study conducted in JPMC. Karachi, to evaluate the efficacy and adverse effects in major depressive disorder individuals. A total of 40 patients irrespective of the gender, aged 18 years up to 65 years were enrolled from OPD of Psychiatry Department. Follow-up visits were carried out fortnightly after making evaluation of symptoms at baseline visit (day 0), follow-up continued till 90 days when the results were compiled.
  
  
  RESULTS
  Statistically significant (p < 0.05) results were observed in all the parameters at the end of study, i.e., day 90.
  
  
  CONCLUSIONS
  Among all the symptoms of major depressive disorder, trazodone proved to be more effective in controlling insomnia.
authors.affiliation: Department of Pharmacology, Basic Medical Sciences Institute, Jinnah Postgraduate Medical Centre, Karachi, Pakistan. dralitunio@yahoo.com
authors.forename: Ali Gul
authors.initials: AG
authors.lastname: Tunio
authors.forename: Moosa
authors.initials: M
authors.lastname: Khan
authors.forename: Dial
authors.initials: D
authors.lastname: Das
authors.forename: Ghulam
authors.initials: G
authors.lastname: Sarwar
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D003865:Major Depressive Disorder / Q000150:complications / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy / Q000209:etiology; D014196:Trazodone / Q000009:adverse effects / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents; D014196:Trazodone