title: Receptor-mediated oligodeoxynucleotides delivery by estradiol and folic acid polylysine conjugates.
abstract: The lack of efficient and specific delivery to target cells still limits the potential application of antisense oligodeoxynucleotides as therapeutic agents in cancer disease. We have covalently linked a polylysine chain (10,000-20,000 mW) to compounds as folic acid, retinoic acid, transferrin, insulin and estradiol, to deliver c-myb antisense oligonucleotide into tumor cells. Using these complexes as carriers for the oligodeoxynucleotides can be achieved an increase in their uptake into target cells through a natural endocytosis pathway.
authors.affiliation: Laboratory of Experimental Chemotherapy, Regina Elena Institute for Cancer Research, Viale Regina Elena 291, 00161, Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Citro
authors.forename: P
authors.initials: P
authors.lastname: Ginobbi
authors.forename: C
authors.initials: C
authors.lastname: Szczylik