title: The ESHRE PGD Consortium: 10 years of data collection.
abstract: BACKGROUND
  Since it was established in 1997, the ESHRE PGD Consortium has been collecting data from international preimplantation genetic diagnosis (PGD) centres. Ten papers have been published, including data from January 1997 to December 2007.
  
  
  METHODS
  The data collection originally used a hard-copy format, then an excel database and finally a FileMaker Pro database. The indications are divided into five categories: PGD for chromosome abnormalities, sexing for X-linked disease, PGD for single gene defects, preimplantation genetic screening (PGS) and PGD for social sexing. The main end-points are pregnancy outcome and follow-up of deliveries.
  
  
  RESULTS
  In data collection I, 16 centres contributed data, which increased to 57 centres by data X (average of 39 centres per data collection). These centres contributed data on over 27 000 cycles that reached oocyte retrieval. Of these cycles, 61% were for aneuploidy screening, 17% for single gene disorders, 16% for chromosomal abnormalities, 4% for sexing of X-linked disease and 2% for social sexing. Cumulatively, 5187 clinical pregnancies gave rise to 4140 deliveries and 5135 newborns (singletons: 3182, twins: 921, triplets: 37).
  
  
  CONCLUSIONS
  In this paper, we present an overview of the first 10 years of PGD data, highlighting trends. These include the introduction of laser-assisted biopsy, an increase in polar body and trophectoderm biopsy, new strategies, methodologies and technologies for diagnosis, including recently arrays, and the more frequent use of freezing biopsied embryos. The Consortium data reports represent a valuable resource for information about the practice of PGD.
authors.affiliation: UCL Centre for PG&D, Institute for Women' s Health, University College London, London, UK. joyce.harper@ucl.ac.uk
authors.forename: J C
authors.initials: JC
authors.lastname: Harper
authors.forename: L
authors.initials: L
authors.lastname: Wilton
authors.forename: J
authors.initials: J
authors.lastname: Traeger-Synodinos
authors.forename: V
authors.initials: V
authors.lastname: Goossens
authors.forename: C
authors.initials: C
authors.lastname: Moutou
authors.forename: S B
authors.initials: SB
authors.lastname: SenGupta
authors.forename: T
authors.initials: T
authors.lastname: Pehlivan Budak
authors.forename: P
authors.initials: P
authors.lastname: Renwick
authors.forename: M
authors.initials: M
authors.lastname: De Rycke
authors.forename: J P M
authors.initials: JP
authors.lastname: Geraedts
authors.forename: G
authors.initials: G
authors.lastname: Harton
mesh_terms: D000782:Aneuploidy; D002869:Chromosome Aberrations; D003625:Data Collection; D016208:Databases, Factual; D005260:Female; D050172:Genes, X-Linked; D040181:Genetic Diseases, X-Linked / Q000175:diagnosis*; D005820:Genetic Testing; D006801:Humans; D011247:Pregnancy; D011256:Pregnancy Outcome; D019836:Preimplantation Diagnosis / Q000379:methods* / Q000706:statistics & numerical data