title: Validation of the Mexican-Spanish version of the EORTC QLQ-C30 and BR23 questionnaires to assess health-related quality of life in Mexican women with breast cancer.
abstract: The aim of this study was to validate the Mexican-Spanish version of The European Organization for Research and Treatment of Cancer (EORTC) QLQ-BR23 questionnaire. The translation procedure followed EORTC guidelines. QLQ-C30 and QLQ-BR23 instruments were completed by Mexican women with breast cancer, attending a teaching referral cancer centre from February 2009 to January 2010. Patients were divided in two groups: (1) Patients with early stage of breast cancer; and (2) Patients with locally advanced breast cancer (LABC). Reliability and validity tests were performed, and validity over time (responsiveness) was conducted in a subset of patients. Two hundred and thirty-four women (mean age, 52.3 years) completed both questionnaires. Convergent and divergent validity was adequate. Cronbach's alpha of all multi-item scales showed values ≥0.7 except for Cognitive and Breast symptoms scales (0.52 and 0.65 respectively). Patients with early stages (n= 77) showed better functional scores and lower symptoms scores than patients with LABC (n= 157). Score means variation after responsiveness analysis demonstrated high sensitivity to change after breast cancer surgery. The Mexican-Spanish version of the EORTC QLQ-BR23 questionnaire is a valid and suitable instrument to estimate HRQL in patients with breast cancer.
authors.affiliation: Clinical Research Division, Instituto Nacional de Cancerología, Av. San Fernando 22, Mexico City, Mexico.
authors.forename: O
authors.initials: O
authors.lastname: Cerezo
authors.forename: L F
authors.initials: LF
authors.lastname: Oñate-Ocaña
authors.forename: P
authors.initials: P
authors.lastname: Arrieta-Joffe
authors.forename: F
authors.initials: F
authors.lastname: González-Lara
authors.forename: M J
authors.initials: MJ
authors.lastname: García-Pasquel
authors.forename: E
authors.initials: E
authors.lastname: Bargalló-Rocha
authors.forename: D
authors.initials: D
authors.lastname: Vilar-Compte
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000523:psychology*; D005260:Female; D006304:Health Status; D006801:Humans; D008800:Mexico; D008875:Middle Aged; D011594:Psychometrics; D011788:Quality of Life; D015203:Reproducibility of Results; D018434:Sickness Impact Profile; D011795:Surveys and Questionnaires / Q000592:standards*