title: Applications of p-hydroxyphenacyl (pHP) and coumarin-4-ylmethyl photoremovable protecting groups.
abstract: Most applications of photoremovable protecting groups have used o-nitrobenzyl compounds and their (often commercially available) derivatives that, however, have several disadvantages. The focus of this review is on applications of the more recently developed title compounds, which are especially well suited for time-resolved biochemical and physiological investigations, because they release the caged substrates in high yield within a few nanoseconds or less. Together, these two chromophores cover the action spectrum for photorelease from >700 nm to 250 nm.
authors.affiliation: Department of Chemistry, University of Kansas, Kansas, USA. givensr@ku.edu
authors.forename: Richard S
authors.initials: RS
authors.lastname: Givens
authors.forename: Marina
authors.initials: M
authors.lastname: Rubina
authors.forename: Jakob
authors.initials: J
authors.lastname: Wirz
mesh_terms: D003374:Coumarins / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D010648:Phenylacetates / Q000138:chemical synthesis / Q000737:chemistry*; D010782:Photolysis; D013997:Time Factors
chemical_list: D003374:Coumarins; D010648:Phenylacetates; C008070:4-hydroxyphenylacetic acid