title: Stevens-johnson syndrome induced by vandetanib.
abstract: Vandetanib is a once-daily oral anticancer drug that selectively inhibits key signaling pathways in cancer by targeting vascular endothelial growth factor receptors, epidermal growth factor receptors tyrosine kinase, and rearranged during transfection-dependent tumor cell proliferation and survival. The most frequently reported adverse events attributed to vandetanib include diarrhea, elevated aminotransferase, asymptomatic corrected QT interval prolongation, and hypertension. Though a number of randomized, doubleblind studies, including cutaneous adverse events attributed to vandetanib, have been reported along with these general symptoms, no case of Stevens-Johnson syndrome (SJS) has been reported. This paper demonstrates a case of SJS induced by vandetanib.
authors.affiliation: Department of Dermatology, Institute of Health Science, School of Medicine, Gyeongsang National University, Jinju, Korea.
authors.forename: Jimi
authors.initials: J
authors.lastname: Yoon
authors.forename: Chee Won
authors.initials: CW
authors.lastname: Oh
authors.forename: Chi Yeon
authors.initials: CY
authors.lastname: Kim