title: [The expression of S-100 protein, CD1a, CD83 and Ki-67 in oral Langerhans cell histiocytosis].
abstract: OBJECTIVE
  To study clinicopathological features, diagnosis, differential diagnosis of oral Langerhans cell histiocytosis (LCH), retrospective clinicopathologic study was carried on and a variety of immune phenotype were detected.
  
  
  METHODS
  The clinicopathological features of 29 cases of oral LCH were analyzed. The immunohistochemical staining of S-100 protein, CD1a, CD83 and Ki-67 were used in above cases by immunohistochemical streptavidin-biotin peroxidase (SP) and Elivison two-step method. Statistical analysis was adopted for the results.
  
  
  RESULTS
  Of the 29 cases of LCH, the expression of S-100 protein and CD1a were positive in 24 cases and negative in 5 cases, so 5 cases were excluded from the diagnosis of LCH. Among 24 cases of LCH, 15 patients were male and 9 were female. The median age was 7.50 years. 14 lesions were in the mandible, 5 were in the maxilla and 5 involved the mandible and maxilla. 9 cases were in stage I, 13 in stage II and 2 in stage III, according to Bartnick classification. Immunohistochemistry showed all 24 cases staining for S-100 protein and CD1a were positive. Comparing with maxillofacial lesions involved soft tissue, Ki-67 positive rate was lower and CD83 positive rate was higher in maxillofacial single bone lesion.
  
  
  CONCLUSIONS
  The immunohistochemical staining of S-100 protein and CD1a are important for the diagnosis of LCH. Maxillofacial bone single LCH might have lower proliferative activity and a higher state of maturity. Maxillofacial LCH involved soft tissue might have a higher proliferative activity and a lower state of maturity.
authors.affiliation: Dept. of Stomatology, Datong No.3 People's Hospital, Datong 037008, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Zhao
authors.forename: Yage
authors.initials: Y
authors.lastname: Zheng
authors.forename: Lihui
authors.initials: L
authors.lastname: Zhang
authors.forename: Tian
authors.initials: T
authors.lastname: Yao
authors.forename: Lanyan
authors.initials: L
authors.lastname: Wu
mesh_terms: D018949:Antigens, CD1; D003937:Diagnosis, Differential; D005260:Female; D006646:Histiocytosis, Langerhans-Cell; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008334:Mandible; D008437:Maxilla; D012189:Retrospective Studies; D009418:S100 Proteins
chemical_list: D018949:Antigens, CD1; C419393:CD1a antigen; D009418:S100 Proteins