title: [The affection of bisphosphonates combined with chemotherapy on bone metabolism index in multiple myeloma].
abstract: OBJECTIVE
  To explore the clinical value of urine N-telopeptides of type I collagen (uNTX) and serum bone specific alkaline phosphatase (sBAP) in myeloma bone disease, and to understand the role of bisphosphonates therapy for multiple myeloma(MM) osteolytic bone lesion.
  
  
  METHODS
  Thirty-three MM cases were treated with bisphosphonates combined with chemotherapy (considered as treatment group), and 20 untreated MM cases with chemotherapy alone considered as control group. uNTX was detected by ELISA, and sBAP by chemiluminescence analysis.
  
  
  RESULTS
  (1) There was no significant differences in uNTX between treatment \[(173.74 ± 14.55) µg/L\] and control groups \[(129.79 ± 12.13) µg/L\] before bisphosphonates treatment (P > 0.05). After six-month treatment, there was significant differences between two groups \[(85.71 ± 8.23) µg/L and (121.59 ± 12.43) µg/L, respectively\] (P < 0.05); Meanwhile, there were significant differences in uNTX between before and after three-month treatment (P = 0.045) and between before and after six-month treatment (P < 0.01) in treatment group. (2) There was no significant differences in sBAP concentration between treatment and control groups \[(4.78 ± 0.55) µg/L and (8.42 ± 1.32) µg/L, respectively\] before treatment (P > 0.05). After six-month treatment, there were significant differences between them \[(16.01 ± 0.52) µg/L and (9.62 ± 1.29) µg/L, respectively\] (P < 0.01). Meanwhile, in treatment group, there was no significant differences between before and after three-month treatment (P > 0.05), but being significant difference between before and after six-month treatment (P < 0.01).
  
  
  CONCLUSIONS
  uNTX, sBAP are important early sensitive index to measure the osteolytic bone lesion in MM patients. Bisphosphonates can significantly improve the osteopathy in MM cases.
authors.affiliation: Department of Hematology, Shanghai Jiaotong University, Shanghai, China.
authors.forename: Xi
authors.initials: X
authors.lastname: Zhang
authors.forename: Chun-kang
authors.initials: CK
authors.lastname: Chang
authors.forename: Ling-yun
authors.initials: LY
authors.lastname: Wu
authors.forename: Zheng
authors.initials: Z
authors.lastname: Zhang
authors.forename: Li-yu
authors.initials: LY
authors.lastname: Zhou
authors.forename: Chao
authors.initials: C
authors.lastname: Xiao
authors.forename: Xiao
authors.initials: X
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D015519:Bone Density; D001842:Bone and Bones / Q000378:metabolism; D024042:Collagen Type I / Q000652:urine; D004164:Diphosphonates / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy* / Q000378:metabolism*
chemical_list: D024042:Collagen Type I; D004164:Diphosphonates; D000469:Alkaline Phosphatase