title: Novel therapeutic strategies to counter Pseudomonas aeruginosa infections.
abstract: Pseudomonas aeruginosa is a highly successful opportunistic pathogen that displays intrinsic multidrug resistance and has a tremendous capacity to acquire further resistance mechanisms. During chronic infection, the bacterium can form a protective biofilm therefore reducing the efficacy of existing antibiotics. P. aeruginosa also harbors an impressive range of virulence factors, many of which are controlled by the quorum-sensing system. Several novel therapeutics are under investigation such as those directed against biofilm formation and quorum-sensing systems along with bacteriophages and immunotherapies. Recent advances in next-generation sequencing and comparative genomics have opened the door to a new wave of smart drug design that could revolutionize P. aeruginosa treatment options.
authors.affiliation: NIHR Biomedical Research Centre in Microbial Disease, University of Liverpool, Daulby Street, Liverpool, L69 3GA, UK.
authors.forename: Joanne L
authors.initials: JL
authors.lastname: Fothergill
authors.forename: Craig
authors.initials: C
authors.lastname: Winstanley
authors.forename: Chloe E
authors.initials: CE
authors.lastname: James
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001422:Bacterial Adhesion / Q000187:drug effects; D001430:Bacteriocins / Q000008:administration & dosage / Q000627:therapeutic use; D018441:Biofilms / Q000187:drug effects / Q000254:growth & development; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D007167:Immunotherapy; D007502:Iron Chelating Agents / Q000008:administration & dosage / Q000627:therapeutic use; D010936:Plant Extracts / Q000008:administration & dosage / Q000627:therapeutic use; D011552:Pseudomonas Infections / Q000276:immunology / Q000382:microbiology / Q000628:therapy*; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000235:genetics; D053038:Quorum Sensing / Q000187:drug effects* / Q000235:genetics; D014774:Virulence / Q000187:drug effects / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D001430:Bacteriocins; D007502:Iron Chelating Agents; D010936:Plant Extracts