title: [Lupus erythematosus panniculitis: clinical and histopathological analysis of 22 cases].
abstract: OBJECTIVE
  To explore the clinical and histopathological manifestations, therapy and prognosis of lupus erythematosus panniculitis (LEP).
  
  
  METHODS
  We retrospectively reviewed the clinical data and histopathological features of 22 cases of LEP diagnosed at Peking Union Medical College Hospital from January 2008 to February 2010.
  
  
  RESULTS
  The lesions appeared as atrophy, erythema, subcutaneous nodules, infiltrated erythema, and ulceration over the scalp, face, upper limbs, and buttock. Histopathological features were lobular panniculitis in the subcutaneous fat; sometimes septal panniculitis could be seen. Hydroxychloroquine sulfate and corticosteroid were effective treatment; most patients responded well to the treatment, while a few experienced recurrence when the treatment tapped or discontinued.
  
  
  CONCLUSIONS
  LEP is a rare cutaneous variant of lupus erythematosus. The diagnosis of LEP is mainly based on clinical findings and pathological features. Hydroxychloroquine and low- and middle-dose corticosteroid are effective for the treatment of LEP.
authors.affiliation: Department of Dermatology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Wang
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.forename: Yue-Hua
authors.initials: YH
authors.lastname: Liu
authors.forename: He-Yi
authors.initials: HY
authors.lastname: Zheng
authors.forename: Qiu-Ning
authors.initials: QN
authors.lastname: Sun
authors.forename: Hong-Zhong
authors.initials: HZ
authors.lastname: Jin
authors.forename: Dong-Lai
authors.initials: DL
authors.lastname: Ma
authors.forename: Tao
authors.initials: T
authors.lastname: Qu
authors.forename: Kai
authors.initials: K
authors.lastname: Fang
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015435:Panniculitis, Lupus Erythematosus / Q000188:drug therapy* / Q000473:pathology*; D011379:Prognosis; D012189:Retrospective Studies; D055815:Young Adult