title: Ganciclovir-resistant cytomegalovirus (CMV) retinitis in a patient with wild-type CMV in her plasma.
abstract: A patient with systemic cytomegalovirus (CMV), including chorioretinitis, received localized and systemic ganciclovir, systemic cidofovir analog, and localized foscarnet. Mutations conferring ganciclovir and cidofovir resistance were detected in CMV from the aqueous fluid but not in CMV from plasma. Quantifying CMV from aqueous fluid was valuable for monitoring the clinical response and predicting resistance.
authors.affiliation: Department of Ophthalmology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, USA.
authors.forename: Hart B
authors.initials: HB
authors.lastname: Moss
authors.forename: Sai
authors.initials: S
authors.lastname: Chavala
authors.forename: Emil
authors.initials: E
authors.lastname: Say
authors.forename: Melissa B
authors.initials: MB
authors.lastname: Miller
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage* / Q000494:pharmacology; D000077404:Cidofovir; D003587:Cytomegalovirus / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification*; D017726:Cytomegalovirus Retinitis / Q000821:virology*; D003596:Cytosine / Q000008:administration & dosage / Q000031:analogs & derivatives; D004279:DNA, Viral / Q000235:genetics; D024882:Drug Resistance, Viral; D005123:Eye / Q000821:virology; D005260:Female; D017245:Foscarnet / Q000008:administration & dosage; D015774:Ganciclovir / Q000008:administration & dosage* / Q000494:pharmacology; D006801:Humans; D063065:Organophosphonates / Q000008:administration & dosage; D010949:Plasma / Q000821:virology*; D017422:Sequence Analysis, DNA
chemical_list: D000998:Antiviral Agents; D004279:DNA, Viral; D063065:Organophosphonates; D017245:Foscarnet; D003596:Cytosine; D000077404:Cidofovir; D015774:Ganciclovir