title: Bottom-up approach to build osteon-like structure by cell-laden photocrosslinkable hydrogel.
abstract: Based on photocrosslinkable PEGDMA and GelMA hydrogels, two "bottom-up" approaches ("circle-and-cross" and "layer-by-layer") were successfully developed to construct osteon-like structures with microchannel networks. Significantly, the "layer-by-layer" approach employing the GelMA hydrogel with a higher biocompatibility was more favorable for building biomimetic osteon.
authors.affiliation: National Engineering Research Center for Biomaterials, Sichuan University, 610064, Chengdu, China.
authors.forename: Yicong
authors.initials: Y
authors.lastname: Zuo
authors.forename: Wenqian
authors.initials: W
authors.lastname: Xiao
authors.forename: Xiaoqin
authors.initials: X
authors.lastname: Chen
authors.forename: Yajun
authors.initials: Y
authors.lastname: Tang
authors.forename: Hongrong
authors.initials: H
authors.lastname: Luo
authors.forename: Hongsong
authors.initials: H
authors.lastname: Fan
mesh_terms: D045744:Cell Line, Tumor; D002470:Cell Survival; D003432:Cross-Linking Reagents / Q000138:chemical synthesis / Q000737:chemistry*; D005780:Gelatin / Q000138:chemical synthesis / Q000737:chemistry*; D061307:Human Umbilical Vein Endothelial Cells / Q000166:cytology; D006801:Humans; D020100:Hydrogels / Q000138:chemical synthesis / Q000737:chemistry*; D008689:Methacrylates / Q000138:chemical synthesis / Q000737:chemistry*; D055668:Photochemical Processes; D011092:Polyethylene Glycols / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D003432:Cross-Linking Reagents; D020100:Hydrogels; D008689:Methacrylates; C421283:poly(ethylene glycol)-dimethacrylate; D011092:Polyethylene Glycols; D005780:Gelatin