title: [Epidemiological and biologic profile of breast cancer in Fez-Boulemane, Morocco].
abstract: In a retrospective study of 265 patients with breast cancer over 3 years (January 2007-September 2009) we examined the epidemiological profile of breast cancer to determine the impact of biological and prognostic factors on survival over 3 years and on the epidemiology of this cancer. Estrogen (RE), progesterone (RP) and human epidermal growth factor receptors (HER2) were evaluated and RE/RP/HER2 status determined. The patients were young (median age 45 years). Invasive tumours were found in 95.5% of the women. The average tumour size was big [3.6 (SD 2.6) cm] and only 14% were histological grade 1. Large tumour size and high histological grade were independent of patient's age. Overall survival at 3 years was only 49% for the RE-/RP-/HER2- subtype and 75% for the RE-/RP-/HER2+ subtype, while it was 96% for the RE+/RP+/HER2- subtype. The young age, large tumour size and high histological grade in our population suggest a lack of awareness of women about breast cancer.
authors.affiliation: Faculté des Sciences et Techniques de Fès, Fès, Maroc.
authors.forename: F
authors.initials: F
authors.lastname: Abbass
authors.forename: S
authors.initials: S
authors.lastname: Bennis
authors.forename: K
authors.initials: K
authors.lastname: Znati
authors.forename: Y
authors.initials: Y
authors.lastname: Akasbi
authors.forename: J K
authors.initials: JK
authors.lastname: Amrani
authors.forename: O
authors.initials: O
authors.lastname: El Mesbahi
authors.forename: A
authors.initials: A
authors.lastname: Amarti
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009018:Morocco / Q000453:epidemiology; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor