title: Hyperglycaemia and vitamin D: a systematic overview.
abstract: Vitamin D plays a role in a range of functions that may impact on glycaemic control. In this study we systematically report on clinical studies evaluating the impact of vitamin D on aspects of hyperglycaemia in non-pregnant adults. A total of 1,294 articles, of which 417 were reviews, were identified. No well-designed randomised, controlled trials were identified that specifically investigated the effects of vitamin D supplementation on glucose and insulin concentrations. The majority of the studies that are available were poorly designed, having limited numbers, short study duration, or were conducted in volunteers with normal baseline, as measured by 25-hydroxyvitamin D (25(OH)D), concentrations or used inadequate doses of the supplements to normalise vitamin D concentrations, or used inappropriate analyses. Most studies did not observe improvements in glycaemia, with few exceptions. The results were more equivocal for aspects of insulin resistance. Most found no benefit on measures of insulin resistance, although some did. However, more studies described improved insulin release, although data from the studies to date are really inadequate to provide any reliable conclusions. Well-conducted randomised, controlled trials with adequate vitamin D doses are required to effectively assess whether this vitamin can reduce the incidence of diabetes.
authors.affiliation: Public Health, Epidemiology and Biostatistics, College of Medical and Dental Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK. gneilthomas@yahoo.co.uk
authors.forename: G Neil
authors.initials: GN
authors.lastname: Thomas
authors.forename: R
authors.initials: R
authors.lastname: Scragg
authors.forename: Chao Q
authors.initials: CQ
authors.lastname: Jiang
authors.forename: Will
authors.initials: W
authors.lastname: Chan
authors.forename: Winfried
authors.initials: W
authors.lastname: Marz
authors.forename: Stefan
authors.initials: S
authors.lastname: Pilz
authors.forename: Hyeon C
authors.initials: HC
authors.lastname: Kim
authors.forename: Brian
authors.initials: B
authors.lastname: Tomlinson
authors.forename: Jos
authors.initials: J
authors.lastname: Bosch
authors.forename: Tai H
authors.initials: TH
authors.lastname: Lam
authors.forename: Bernard M Y
authors.initials: BM
authors.lastname: Cheung
authors.forename: Kar K
authors.initials: KK
authors.lastname: Cheng
mesh_terms: D000328:Adult; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000188:drug therapy; D007333:Insulin Resistance; D008297:Male; D014807:Vitamin D / Q000031:analogs & derivatives / Q000097:blood* / Q000627:therapeutic use; D014815:Vitamins / Q000097:blood* / Q000627:therapeutic use
chemical_list: D014815:Vitamins; D014807:Vitamin D; C104450:25-hydroxyvitamin D