title: CD5 expression promotes multiple intracellular signaling pathways in B lymphocyte.
abstract: CD5(+) B lymphocytes have distinct functional properties compared with B lymphocytes that lack CD5. However, it remains unclear if and how the CD5 molecule modulates B lymphocyte biology and responses. Our recent studies have revealed that CD5 promotes constitutive activation of multiple signaling pathways including extracellular signal-regulated kinases (ERK1/2), phosphatidylinositol 3-kinase (PI-3K)/mammalian target of rapamycin (mTOR) and calcineurin-NFAT signaling pathways. Further, changes in cytokine production including the production of IL-10 are related to the activation of the transcription factors NFAT2 and STAT3. All in all, these studies provide a framework for understanding how CD5 impacts B lymphocyte biology and responses.
authors.affiliation: Queen Mary University of London, William Harvey Research Institute, UK. r.a.mageed@qmul.ac.uk
authors.forename: Rizgar A
authors.initials: RA
authors.lastname: Mageed
authors.forename: Soizic
authors.initials: S
authors.lastname: Garaud
authors.forename: Taher E
authors.initials: TE
authors.lastname: Taher
authors.forename: Kaushal
authors.initials: K
authors.lastname: Parikh
authors.forename: Jacques-Olivier
authors.initials: JO
authors.lastname: Pers
authors.forename: Christophe
authors.initials: C
authors.lastname: Jamin
authors.forename: Yves
authors.initials: Y
authors.lastname: Renaudineau
authors.forename: Pierre
authors.initials: P
authors.lastname: Youinou
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism*; D018956:CD5 Antigens / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D020033:Protein Isoforms; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D018956:CD5 Antigens; D020033:Protein Isoforms