title: Formula for calculating standard liver volume in Indians.
abstract: OBJECTIVE
  To assess the validity of standard liver volume (SLV) calculated using various formulae in the Indian population.
  
  
  METHODS
  Data on liver weights of 366 cadavers with no intrinsic liver disease were obtained retrospectively from autopsy records. From these, liver volume (LV) was calculated using the density of formalin-preserved livers, measured prospectively in 15 livers. These volumes were compared with SLV estimated using various formulae.
  
  
  RESULTS
  The liver density was found to be 1.162 kg/L. Median (range) age of 366 autopsied cadavers (M:F = 274:92) was 49 [18-70] years. Median (range) body surface area (BSA) and LV was 1.66 (1.25-2.12) square meter and 1,205 (685.3-2102) cc, respectively. There was poor agreement between LV obtained from autopsy data and SLV estimated using formulae derived from the Indians (Indian Model 1: ICC = -0.069, p = 0.655; Indian Model 2: ICC = -0.07015, p = 0.879; Indian Model 3: ICC = -0.06253, p = 0.043), Koreans (ICC = -0.07114, p = <0.0001), Chinese (ICC = -0.0286, p = <0.0001) and Johnson Model (ICC = -0.05764, p = <0.0001). Median difference between the actual LV and SLV as estimated by the Indian Models 1 and 2 are least (29 cc and 6 cc, respectively) and this was followed by Johnson and the Korean Models (149.9 cc and 158.7 cc, respectively). Median difference was the highest with the Indian Model 3 (475.9 cc), followed by Chinese Model (-209.8 cc).
  
  
  CONCLUSIONS
  There is poor correlation between the total LV and SLV obtained by various formulae and none are valid in assessing SLV in Indian population.
authors.affiliation: Department of Radiology, Christian Medical College, Vellore, Tamil Nadu 632 004, India. anuradhachandramohan@gmail.com
authors.forename: Anuradha
authors.initials: A
authors.lastname: Chandramohan
authors.forename: Banumathi
authors.initials: B
authors.lastname: Ramakrishna
authors.forename: Sitaram
authors.initials: S
authors.lastname: Venkatramani
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000465:Algorithms; D005260:Female; D006801:Humans; D007194:India; D008099:Liver / Q000033:anatomy & histology*; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D012016:Reference Values; D012189:Retrospective Studies; D055815:Young Adult