title: Simultaneous thin-layer chromatography-densitometric analysis of sibutramine and citalopram.
abstract: Due the presence of sibutramine and citalopram in a number of drugs, neurotransmitter reuptake inhibitors. Sibutramine reduces the reuptake of serotonin, norepinephrine, and dopamine; citalopram is an antidepressant drug of the selective serotonin reuptake inhibitor. The thin-layer chromatography-densitometric behavior of some centrally acting serotonin reuptake inhibitors has been studied. The proposed analytical method is suitable for qualitative and quantitative analysis of sibutramine and citalopram.
authors.affiliation: Department of Pharmaceutical Sciences, Faculty of Pharmacy, Medical University, Sofia, Bulgaria. phddanka@yahoo.com
authors.forename: Danka P
authors.initials: DP
authors.lastname: Obreshkova
authors.forename: Lily P
authors.initials: LP
authors.lastname: Peikova
mesh_terms: D000928:Antidepressive Agents / Q000032:analysis*; D002855:Chromatography, Thin Layer / Q000379:methods*; D015283:Citalopram / Q000032:analysis*; D003503:Cyclobutanes / Q000032:analysis*; D003720:Densitometry / Q000379:methods*
chemical_list: D000928:Antidepressive Agents; D003503:Cyclobutanes; D015283:Citalopram; C058254:sibutramine