title: Antischistosomal activity of trioxaquines: in vivo efficacy and mechanism of action on Schistosoma mansoni.
abstract: Schistosomiasis is among the most neglected tropical diseases, since its mode of spreading tends to limit the contamination to people who are in contact with contaminated waters in endemic countries. Here we report the in vitro and in vivo anti-schistosomal activities of trioxaquines. These hybrid molecules are highly active on the larval forms of the worms and exhibit different modes of action, not only the alkylation of heme. The synergy observed with praziquantel on infected mice is in favor of the development of these trioxaquines as potential anti-schistosomal agents.
authors.affiliation: Université de Perpignan Via Domitia, Perpignan, France.
authors.forename: Julien
authors.initials: J
authors.lastname: Portela
authors.forename: Jérôme
authors.initials: J
authors.lastname: Boissier
authors.forename: Benjamin
authors.initials: B
authors.lastname: Gourbal
authors.forename: Vincent
authors.initials: V
authors.lastname: Pradines
authors.forename: Vincent
authors.initials: V
authors.lastname: Collière
authors.forename: Frédéric
authors.initials: F
authors.lastname: Coslédan
authors.forename: Bernard
authors.initials: B
authors.lastname: Meunier
authors.forename: Anne
authors.initials: A
authors.lastname: Robert
mesh_terms: D000634:Aminoquinolines / Q000008:administration & dosage* / Q000494:pharmacology*; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage* / Q000494:pharmacology*; D004357:Drug Synergism; D005260:Female; D006801:Humans; D007814:Larva / Q000187:drug effects; D008297:Male; D051379:Mice; D011223:Praziquantel / Q000008:administration & dosage / Q000494:pharmacology; D012550:Schistosoma mansoni / Q000187:drug effects*; D012555:Schistosomiasis mansoni / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000634:Aminoquinolines; D000871:Anthelmintics; D011223:Praziquantel