title: Translocation t(12;17)(q24.1;q21) as the sole anomaly in a nasal chondromesenchymal hamartoma arising in a patient with pleuropulmonary blastoma.
abstract: The identification of recurrent chromosomal abnormalities in benign and malignant mesenchymal neoplasms has provided important pathogenetic insight as well as powerful diagnostic adjuncts. Nasal chondromesenchymal hamartoma (NCMH), an extremely rare benign tumor arising in the sinonasal tract of infants and children, has not been previously subjected to cytogenetic analysis. Histopathologically composed of mixed mesenchymal elements, NCMH exhibits a relatively wide differential diagnosis to include chondromyxoid fibroma, chondroblastoma, aneurysmal bone cyst, fibrous dysplasia, and osteochondromyxoma. An interesting association with pleuropulmonary blastoma has been reported in a small subset of NCMH patients. In the current study, cytogenetic analysis of a NCMH arising in an 11-year-old boy with a past medical history of pleuropulmonary blastoma revealed a novel 12;17 translocation, t(12;17)(q24.1;q21), as the sole anomaly.
authors.affiliation: Department of Pathology and Microbiology, Children's Hospital and Medical Center, Omaha, NE, USA.
authors.forename: Radwa El
authors.initials: RE
authors.lastname: Behery
authors.forename: Jiri
authors.initials: J
authors.lastname: Bedrnicek
authors.forename: Audrey
authors.initials: A
authors.lastname: Lazenby
authors.forename: Marilu
authors.initials: M
authors.lastname: Nelson
authors.forename: Jennifer
authors.initials: J
authors.lastname: Grove
authors.forename: Dali
authors.initials: D
authors.lastname: Huang
authors.forename: Russell
authors.initials: R
authors.lastname: Smith
authors.forename: Julia A
authors.initials: JA
authors.lastname: Bridge
mesh_terms: D059786:Abnormal Karyotype; D002356:Cartilage / Q000473:pathology; D002648:Child; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics; D006222:Hamartoma / Q000150:complications* / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008297:Male; D008648:Mesoderm / Q000473:pathology; D009668:Nose Diseases / Q000150:complications* / Q000235:genetics* / Q000473:pathology; D018202:Pulmonary Blastoma / Q000150:complications* / Q000235:genetics; D014178:Translocation, Genetic