title: Experimental encephalitis caused by Taenia crassiceps cysticerci in mice.
abstract: OBJECTIVE
  To present the experimental model of neurocysticercosis (NCC) caused by Taenia crassiceps cysticerci, to describe the inflammatory process, susceptibility, or resistance of BALB/c and C57BL/6 mice to this infection, and to describe the host-parasite relationship.
  
  
  METHODS
  The animals were intracranially inoculated with initial stage T. crassiceps cysticerci. They were euthanized at 7, 30, 60, and 90 days after the inoculation. Their encephala were removed for the histopathologic analysis, classification of the parasites, and inflammatory lesions.
  
  
  RESULTS
  Experimental NCC was observed on both mice lineages. BALB/c mice presented inflammatory lesions with greater intensity, inducing necrosis on late stage parasites, and with an acute inflammation pattern, while C57BL/6 mice showed greater capability on provoking early necrosis in the cysticerci, which showed a chronic inflammation pattern.
  
  
  CONCLUSIONS
  This experimental model induced NCC on mice with characteristic inflammation and lesions. C57BL/6 mice were able to induce precocious necrosis of the parasites presenting inflammatory lesions with lower intensity.
authors.affiliation: Instituto de Patologia Tropical e Saúde Pública, Universidade Federal de Goiás, Goiânia, GO, Brazil.
authors.forename: Hidelberto
authors.initials: H
authors.lastname: Matos-Silva
authors.forename: Bruno Pereira
authors.initials: BP
authors.lastname: Reciputti
authors.forename: Elbio Cândido de
authors.initials: EC
authors.lastname: Paula
authors.forename: André Luiz
authors.initials: AL
authors.lastname: Oliveira
authors.forename: Vânia Beatriz Lopes
authors.initials: VB
authors.lastname: Moura
authors.forename: Marina Clare
authors.initials: MC
authors.lastname: Vinaud
authors.forename: Milton Adriano Pelli
authors.initials: MA
authors.lastname: Oliveira
authors.forename: Ruy de Souza
authors.initials: Rde S
authors.lastname: Lino-Júnior
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004660:Encephalitis / Q000469:parasitology* / Q000473:pathology; D005260:Female; D006790:Host-Parasite Interactions; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D020019:Neurocysticercosis / Q000469:parasitology* / Q000473:pathology; D012720:Severity of Illness Index; D013621:Taenia / Q000502:physiology*