title: Keratocystic odontogenic tumors and Carnoy's solution: results and complications assessment.
abstract: OBJECTIVE
  Keratocystic odontogenic tumors (KOTs) can be treated with Carnoy's solution, although this treatment modality is not free from complications. It is important to verify the incidence of complications after the use of Carnoy's solution and compare these with the literature.
  
  
  METHODS
  This study verified the effects of a complementary treatment for KOTs and assessed the incidence of such complications as recurrence, infection, sequestrum formation, mandibular fracture, dehiscence, and neuropathy.
  
  
  RESULTS
  Twenty-two KOTs treated with Carnoy's solution combined with peripheral ostectomy were included, and the follow-up period varied from 12 to 78months with a mean of 42.9months. Complications included recurrence (4.5%), dehiscence (22.7%), infection (4.5%), and paresthesia (18.2%). No difference was found among lesions associated (9.1%) or not (0%) with nevoid basal cell carcinoma syndrome (P>0.05). Dehiscence was influenced by marsupialization (P<0.05), and paresthesia was observed exclusively in cases of mandibular canal fenestration (P<0.01).
  
  
  CONCLUSIONS
  Complementary treatment with Carnoy's solution and peripheral ostectomy appear to provide efficient treatment for KOTs. Complications originating from the use of the solution are less frequent and less serious than complications associated with cryotherapy. Neuropathy seems to be related to direct contact between the solution and the epineurium.
authors.affiliation: Department of Stomatology, Faculdade de Odontologia da Universidade de São Paulo, USP, São Paulo, SP, Brazil.
authors.forename: O
authors.initials: O
authors.lastname: Ribeiro Junior
authors.forename: A M
authors.initials: AM
authors.lastname: Borba
authors.forename: C A F
authors.initials: CA
authors.lastname: Alves
authors.forename: M M
authors.initials: MM
authors.lastname: de Gouveia
authors.forename: F L
authors.initials: FL
authors.lastname: Coracin
authors.forename: J
authors.initials: J
authors.lastname: Guimarães Júnior
mesh_terms: D019342:Acetic Acid / Q000009:adverse effects / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002725:Chloroform / Q000009:adverse effects / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D000431:Ethanol / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005404:Fixatives / Q000009:adverse effects; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008337:Mandibular Fractures / Q000209:etiology; D008339:Mandibular Neoplasms / Q000188:drug therapy / Q000601:surgery; D008340:Mandibular Nerve / Q000187:drug effects / Q000503:physiopathology; D008441:Maxillary Neoplasms / Q000188:drug therapy / Q000601:surgery; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D009808:Odontogenic Tumors / Q000188:drug therapy* / Q000601:surgery; D010027:Osteotomy / Q000009:adverse effects; D010292:Paresthesia / Q000209:etiology; D011183:Postoperative Complications; D012189:Retrospective Studies; D013529:Surgical Wound Dehiscence / Q000209:etiology; D013530:Surgical Wound Infection / Q000209:etiology; D013697:Thermosensing / Q000502:physiology; D013997:Time Factors; D014110:Touch / Q000502:physiology; D061221:Trigeminal Nerve Injuries / Q000209:etiology; D055815:Young Adult
chemical_list: C033474:Carnoy's solution; D005404:Fixatives; D000431:Ethanol; D002725:Chloroform; D019342:Acetic Acid