title: Cortical structural abnormalities in deficit versus nondeficit schizophrenia.
abstract: OBJECTIVE
  To examine the structural integrity of the dorsolateral prefrontal-basal ganglia-thalamocortical circuit in people with the deficit form of schizophrenia.
  
  
  METHODS
  A three-dimensional structural MRI sequence was used to conduct morphometric assessments of cortical and subcortical regions in deficit and nondeficit outpatients with schizophrenia and healthy controls.
  
  
  RESULTS
  The superior prefrontal and superior and middle temporal gyral gray matter volumes were significantly smaller in the deficit versus the nondeficit group and normal control groups. There were no significant group differences in examined subcortical structures.
  
  
  CONCLUSIONS
  People with deficit schizophrenia are characterized by selective reductions in the prefrontal and temporal cortex.
authors.affiliation: Veterans Affairs Capital Network (VISN 5) Mental Illness Research, Education, and Clinical Center, Baltimore, Maryland, USA.
authors.forename: Bernard A
authors.initials: BA
authors.lastname: Fischer
authors.forename: William R
authors.initials: WR
authors.lastname: Keller
authors.forename: Celso
authors.initials: C
authors.lastname: Arango
authors.forename: Godfrey D
authors.initials: GD
authors.lastname: Pearlson
authors.forename: Robert P
authors.initials: RP
authors.lastname: McMahon
authors.forename: Walter A
authors.initials: WA
authors.lastname: Meyer
authors.forename: Alan
authors.initials: A
authors.lastname: Francis
authors.forename: Brian
authors.initials: B
authors.lastname: Kirkpatrick
authors.forename: William T
authors.initials: WT
authors.lastname: Carpenter
authors.forename: Robert W
authors.initials: RW
authors.lastname: Buchanan
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology*; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000473:pathology / Q000502:physiology; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000473:pathology* / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D055815:Young Adult