title: [Relationship between EPHX2 gene polymorphism and essential hypertension in Kazaks and Hans in Xinjiang].
abstract: OBJECTIVE
  To investigate the association between rs751141 gene polymorphisms in EPHX2 gene and essential hypertension in Kazak and Han in Xinjiang.
  
  
  METHODS
  A total of 267 essential hypertensive patients in Kazaks, 368 essential hypertensive patients in Hans, 284 normotensive controls in Kazaks and 348 normotensive controls in Hans were enrolled in this study. TaqMan assay was used to detect the rs751141 G/A gene polymorphisms of EPHX2 gene.
  
  
  RESULTS
  The rs751141 G/A genotype frequencies for GA + AA genotypes was 40.2 percent in essential hypertensive subjects and 52.0 percent in control subjects in Hans, respectively. The genotype frequencies were significant difference between the two groups in Hans in Xinjiang (P < 0.01). The rs751141G/A gene polymorphism had no significant difference between essential hypertensive patients and normotensive controls in Kazaks in Xinjiang (P > 0.05).
  
  
  CONCLUSIONS
  The essential hypertension in Kazaks in Xinjiang is not associated with rs751141G/A gene polymorphism of EPHX2 gene, but the essential hypertension in Hans in Xinjiang is associated with rs751141G/A allele gene polymorphism of EPHX2 gene. A type of rs751141 allele gene polymorphism may be the independent protective factor of essential hypertension in Hans in Xinjiang.
authors.affiliation: Department of Cardiology, the First Affiliated Hospital, Medical College of Shihezi University, Shihezi 832008, China.
authors.forename: Na
authors.initials: N
authors.lastname: Li
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Hu
authors.initials: H
authors.lastname: Ding
authors.forename: Zhong
authors.initials: Z
authors.lastname: Wang
authors.forename: Dao-wen
authors.initials: DW
authors.lastname: Wang
authors.forename: Yu-jun
authors.initials: YJ
authors.lastname: Xu
authors.forename: Wang-qiang
authors.initials: WQ
authors.lastname: Zhang
authors.forename: Jun-cang
authors.initials: JC
authors.lastname: Duan
authors.forename: Yue-hong
authors.initials: YH
authors.lastname: Wang
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics; D002681:China / Q000453:epidemiology; D004851:Epoxide Hydrolases / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D004851:Epoxide Hydrolases; C506428:EPHX2 protein, human