title: High prevalence of human bocavirus 1 in infants with lower acute respiratory tract disease in Argentina, 2007-2009.
abstract: Human bocavirus (HBoV) is a parvovirus whose association with respiratory disease is currently under investigation.
  
  
  OBJECTIVE
  To determine HBoV prevalence in children with lower acute respiratory infection.
  
  
  METHODS
  We investigated HBoV in 433 nasopharyngeal aspirates collected in 2007-2009 from children 0 to 5 years old hospitalized with bronchiolitis or pneumonia in Córdoba, Argentina.
  
  
  RESULTS
  The general prevalence of HBoV was 21.5% and the positive cases (HBoV+) were more frequent during winter and spring. The mean age of HBoV+ patients was 6.9 months, with 87.1% of the detections corresponding to infants less than 1 year old (among which the prevalence of HBoV was 26.3% in patients < 3 months of age, 22.1% in 3 to 6 months, 25.3% in 6 to 9 months, and 18.8% in 9 to 12 months). The sequence analysis of the NP1 coding region of 15 isolates showed that all isolates from Cordoba were HBoV1 which exhibited a homology of nearly 100% both among themselves and with the originally discovered virus from 2005.
  
  
  CONCLUSIONS
  Overall, our results indicate that HBoV is a significant pathogen that contributes to acute respiratory infection both on its own and during coinfection with other viruses.
authors.affiliation: Instituto de Virología Dr. J.M. Vanella, Medical School, Universidad Nacional de Córdoba, Argentina.
authors.forename: Lucía María
authors.initials: LM
authors.lastname: Ghietto
authors.forename: Alicia
authors.initials: A
authors.lastname: Cámara
authors.forename: Yumei
authors.initials: Y
authors.lastname: Zhou
authors.forename: Mauro
authors.initials: M
authors.lastname: Pedranti
authors.forename: Silvia
authors.initials: S
authors.lastname: Ferreyra
authors.forename: Teryl
authors.initials: T
authors.lastname: Frey
authors.forename: Jorge
authors.initials: J
authors.lastname: Cámara
authors.forename: Maria Pilar
authors.initials: MP
authors.lastname: Adamo
mesh_terms: D000208:Acute Disease; D001118:Argentina / Q000453:epidemiology; D001990:Bronchiolitis, Viral / Q000453:epidemiology / Q000821:virology*; D002675:Child, Preschool; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D056661:Human bocavirus / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009305:Nasopharynx / Q000821:virology; D010322:Parvoviridae Infections / Q000453:epidemiology / Q000821:virology*; D010802:Phylogeny; D011024:Pneumonia, Viral / Q000453:epidemiology / Q000821:virology*; D016133:Polymerase Chain Reaction; D015995:Prevalence
chemical_list: D004279:DNA, Viral