title: A prototype stimulator system for noninvasive Low Intensity Focused Ultrasound delivery.
abstract: A prototype Low Intensity Focused Ultrasound (LIFU) stimulator system was developed to evaluate non-invasive neuromodulation in a large animal model. We conducted a feasibility study on a Göttingen minipig, demonstrating reversible, targeted transcranial neuromodulation. The hypothalamus of the minipig was repeatedly stimulated with LIFU which evoked temporally correlated increases in both heart rate and blood pressure.
authors.affiliation: Center for Advanced Surgical and Interventional Technology (CASIT), Los Angeles, CA 90095, USA. amitm@ucla.edu
authors.forename: Amit P
authors.initials: AP
authors.lastname: Mulgaonkar
authors.forename: Rahul S
authors.initials: RS
authors.lastname: Singh
authors.forename: Meghedi
authors.initials: M
authors.lastname: Babakhanian
authors.forename: Martin O
authors.initials: MO
authors.lastname: Culjat
authors.forename: Warren S
authors.initials: WS
authors.lastname: Grundfest
authors.forename: Alessandra
authors.initials: A
authors.lastname: Gorgulho
authors.forename: Goran
authors.initials: G
authors.lastname: Lacan
authors.forename: Antonio A F
authors.initials: AA
authors.lastname: De Salles
authors.forename: Alexander
authors.initials: A
authors.lastname: Bystritsky
authors.forename: William P
authors.initials: WP
authors.lastname: Melega
mesh_terms: D000818:Animals; D003198:Computer Simulation; D005240:Feasibility Studies; D007031:Hypothalamus / Q000000981:diagnostic imaging*; D023421:Models, Animal; D013552:Swine; D014465:Ultrasonics / Q000379:methods*; D014463:Ultrasonography / Q000379:methods*