title: A Danish national cohort study on neonatal outcome in singleton pregnancies with placenta previa.
abstract: OBJECTIVE
  To describe the incidence of placenta previa and to assess neonatal morbidity and mortality in pregnancies with placenta previa after adjustment for previous cesarean section, smoking, multiparity, maternal age and in vitro fertilization.
  
  
  METHODS
  National cohort study.
  
  
  METHODS
  Danish national IVF-, birth- and patient registers.
  
  
  METHODS
  All pregnancies in Denmark from 1978-2006 and a subpopulation of all singleton pregnancies during the years 2001-2006 with placenta previa (n=1721) compared to pregnancies without this diagnosis.
  
  
  METHODS
  Incidence rates and multivariate analysis.
  
  
  METHODS
  Gestational age, birthweight, Apgar score after five minutes, stillbirth, neonatal mortality and admittance to neonatal intensive care unit.
  
  
  RESULTS
  The incidence of placenta previa in Denmark was 0.54% in 2006. Neonates born after pregnancies with placenta previa had a higher risk of being born at a gestational age below 37 weeks (OR 8.6; 95%CI 7.5-9.9), having an Apgar score of ≤7 at five minutes (OR 2.7; 95%CI 2.0-3.7), being transferred to a neonatal intensive care unit (OR 4.3; 95%CI 3.8-4.9) and for stillbirth and neonatal mortality combined (OR 1.8; 95%CI 1.1-3.0), compared with neonates born in pregnancies without placenta previa. No increased risk of being small-for-gestational age was found (OR 1.0; 95%CI 1.0-1.2).
  
  
  CONCLUSIONS
  When adjusting for confounders, neonates born after pregnancies with placenta previa had a significantly higher risk of being born preterm, having a low Apgar score, being transferred to neonatal intensive care, and death.
authors.affiliation: Department of Obstetrics and Gynecology, Hillerød University Hospital, Hillerød Fertility Clinic 4071, Rigshospitalet University Hospital, Copenhagen, Denmark. lonenoergaard@dadlnet.dk
authors.forename: Lone N
authors.initials: LN
authors.lastname: Nørgaard
authors.forename: Anja
authors.initials: A
authors.lastname: Pinborg
authors.forename: Øjvind
authors.initials: Ø
authors.lastname: Lidegaard
authors.forename: Thomas
authors.initials: T
authors.lastname: Bergholt
mesh_terms: D000328:Adult; D001034:Apgar Score; D001724:Birth Weight; D016022:Case-Control Studies; D002585:Cesarean Section / Q000706:statistics & numerical data; D015331:Cohort Studies; D003718:Denmark / Q000453:epidemiology; D005260:Female; D005865:Gestational Age; D006801:Humans; D015994:Incidence; D007226:Infant Mortality; D007231:Infant, Newborn; D010923:Placenta Previa / Q000453:epidemiology*; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology*; D012042:Registries; D012307:Risk Factors