title: Ovarian cancer screening.
abstract: Annual screening of asymptomatic postmenopausal women using a combination of transvaginal sonography and serum Ca-125 has been evaluated in 4 major clinical trials as a means to facilitate earlier detection of ovarian cancer. In several trials, screening has caused a decrease in stage at detection. These ovarian cancer screening trials are reviewed. The effect of screening on ovarian cancer mortality varies in different trials and is the subject of further investigation.
authors.affiliation: Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Kentucky Chandler Medical Center-Markey Cancer Center, Lexington, Kentucky, USA. Jrvann2@email.uky.edu
authors.forename: John R
authors.initials: JR
authors.lastname: van Nagell
authors.forename: Edward John
authors.initials: EJ
authors.lastname: Pavlik
mesh_terms: D000465:Algorithms; D018394:CA-125 Antigen / Q000097:blood; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008403:Mass Screening; D010051:Ovarian Neoplasms / Q000175:diagnosis* / Q000517:prevention & control*; D010053:Ovary / Q000000981:diagnostic imaging; D012107:Research Design; D014463:Ultrasonography
chemical_list: D018394:CA-125 Antigen