title: Ketamine-associated corneal edema.
abstract: OBJECTIVE
  To report a case of ketamine-associated corneal edema.
  
  
  METHODS
  Case report.
  
  
  RESULTS
  A 61-year-old man prescribed oral ketamine for refractory depression developed bilateral corneal edema. This immediately resolved off ketamine and recurred with rechallenge. Rapid corneal endothelial cell loss occurred during this period.
  
  
  CONCLUSIONS
  Ketamine may induce potentially reversible corneal edema with endothelial cell loss. A thorough medication history of this and other drugs should be sought in patients with an otherwise unexplained corneal endothelial failure.
authors.affiliation: Save Sight Institute, University of Sydney, Sydney, Australia.
authors.forename: Julia Mary
authors.initials: JM
authors.lastname: Starte
authors.forename: Adrian Tien-Chin
authors.initials: AT
authors.lastname: Fung
authors.forename: Yves Axel
authors.initials: YA
authors.lastname: Kerdraon
mesh_terms: D015715:Corneal Edema / Q000139:chemically induced* / Q000503:physiopathology; D004728:Endothelium, Corneal / Q000187:drug effects*; D018691:Excitatory Amino Acid Antagonists / Q000009:adverse effects*; D006801:Humans; D007649:Ketamine / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D014792:Visual Acuity / Q000502:physiology
chemical_list: D018691:Excitatory Amino Acid Antagonists; D007649:Ketamine