title: Association between functional polymorphism of the AVPR1b gene and polymorphism rs1293651 of the CRHR1 gene and bipolar disorder with psychotic features.
abstract: BACKGROUND
  An association between HPA-axis disturbances and susceptibility towards depression with psychotic features has been reported. NR3C1, CRHR1 and AVPR1b are the key components of this system. We investigated the possible involvement of the polymorphisms of those genes with the susceptibility to psychotic features in the course of BP I disorder.
  
  
  METHODS
  The study was conducted on 194 patients with psychotic features in the course of BPI. Control group consisted of 732 healthy subjects. Genotyping for NR3C1, AVPR1b and CRHR1 polymorphisms was done with use of TagMan SNP Genotyping Assays.
  
  
  RESULTS
  The association of polymorphisms rs28536160 genotype TT of the AVPR1b gene and polymorphisms rs1293651 of CRHR1 gene with psychotic features in the course of BPI.
  
  
  CONCLUSIONS
  The main limitation of our study is the small sample size of the group of patients with psychotic features.
  
  
  CONCLUSIONS
  The results of our study suggest that the studied polymorphisms may increase susceptibility for obtaining psychotic features in the course of BP I.
authors.affiliation: Department of Adult Psychiatry, Poznan University of Medical Sciences, ul. Szpitalna 27/33, 60-572 Poznan, Poland. alrodziewicz@ump.edu.pl
authors.forename: Anna
authors.initials: A
authors.lastname: Leszczyńska-Rodziewicz
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Szczepankiewicz
authors.forename: Monika
authors.initials: M
authors.lastname: Dmitrzak-Węglarz
authors.forename: Maria
authors.initials: M
authors.lastname: Skibińska
authors.forename: Joanna
authors.initials: J
authors.lastname: Hauser
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000235:genetics*; D005260:Female; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010913:Pituitary-Adrenal System / Q000503:physiopathology; D011110:Polymorphism, Genetic; D011618:Psychotic Disorders / Q000235:genetics*; D018019:Receptors, Corticotropin-Releasing Hormone / Q000235:genetics*; D011965:Receptors, Glucocorticoid / Q000235:genetics; D017483:Receptors, Vasopressin / Q000235:genetics*; D055815:Young Adult; D000099052:CRF Receptor, Type 1
chemical_list: C497713:NR3C1 protein, human; D018019:Receptors, Corticotropin-Releasing Hormone; D011965:Receptors, Glucocorticoid; D017483:Receptors, Vasopressin; D000099052:CRF Receptor, Type 1