title: Yoropyrazone, a new naphthopyridazone alkaloid isolated from Streptomyces sp. IFM 11307 and evaluation of its TRAIL resistance-overcoming activity.
abstract: A new naphthopyridazone derivative, yoropyrazone (1), has been isolated from Streptomyces sp. IFM 11307. The structure of the new compound was established on the basis of spectroscopic analyses. Compound 1 (10 μM) in combination with TRAIL moderately showed cytotoxic activity in sensitizing TRAIL-resistant human gastric adenocarcinoma (AGS) cells.
authors.affiliation: Chemistry Department, Faculty of Science, Helwan University, Cairo, Egypt.
authors.forename: Mohamed S
authors.initials: MS
authors.lastname: Abdelfattah
authors.forename: Kazufumi
authors.initials: K
authors.lastname: Toume
authors.forename: Masami
authors.initials: M
authors.lastname: Ishibashi
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D019008:Drug Resistance, Neoplasm; D006801:Humans; D009281:Naphthalenes / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D011720:Pyrazoles / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D013057:Spectrum Analysis; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology; D013302:Streptomyces / Q000378:metabolism*; D053221:TNF-Related Apoptosis-Inducing Ligand / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D009281:Naphthalenes; D011720:Pyrazoles; D053221:TNF-Related Apoptosis-Inducing Ligand; C573846:yoropyrazone