title: Experience of application: blood screening and bone turnover markers for prevention of unwanted effects and early outcomes of teriparatide.
abstract: This clinical study aimed to provide awareness of the teriparatide injection and also prevention of unwanted events. The 72 cases aged between 52-69 with the inclusion criteria: back pain proved by the x-ray with one or more collapsed spines, no underlying diseases and no history of bone tumor, hyperparathyroid, hypercalcemia. The blood screening for renal, liver profiles, uric acid, mineral profile and bone turnover markers (bCTx, PINP) are used as 6-month monitor. The results showed that the common unwanted effects were hypercalcemia, hyperuricemia, hypomagnesia: 5.5%, 54.56% and 43% respectively at the first month of the therapy. At the end of 6th month, these conditions occurred 1.38%, 8.77% and 5.5% respectively. The bone turnover markers, PINP, was a quick response in the first month, the PINP was double increased then triple increased at the end of the 6th month (p = 0.001). Teriparatide did not disturb the activity of parathyroid glands because the PTH was within the normal limit during the treatment (p = 0.001). The blood screening monitor was useful for preventing the unwanted effects and the bone turnover markers, PINP was beneficial for evaluation of Teriparatide efficacy in short outcomes leading to physicians and patients' confidence.
authors.affiliation: Department of Orthopaedic Surgery, Siriraj Hospital, Mahidol University, Bangkok, Thailand. todrnarong@yahoo.com
authors.forename: Narong
authors.initials: N
authors.lastname: Bunyaratavej
mesh_terms: D000368:Aged; D050071:Bone Density Conservation Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001862:Bone Resorption / Q000097:blood; D005260:Female; D006801:Humans; D008875:Middle Aged; D008991:Monitoring, Physiologic; D010446:Peptide Fragments / Q000097:blood; D011347:Procollagen / Q000097:blood; D019379:Teriparatide / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D050071:Bone Density Conservation Agents; D010446:Peptide Fragments; D011347:Procollagen; C047202:procollagen Type I N-terminal peptide; D019379:Teriparatide