title: A general preparation of protected phosphoamino acids.
abstract: Fmoc-O-benzyl-l-phosphoserine is an important building block in the synthesis of Forigerimod, a phosphopeptide being investigated for Systemic Lupus Erythematosus (SLE). An efficient one-pot process was developed using inexpensive, readily available starting materials. This general procedure was used to prepare a variety of protected phosphoamino acids.
authors.affiliation: Chemical Process Research and Development, Cephalon Inc., 383 Phoenixville Pike, Malvern, Pennsylvania 19355, USA. dpetrill@cephalon.com
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Petrillo
authors.forename: Dale R
authors.initials: DR
authors.lastname: Mowrey
authors.forename: Shawn P
authors.initials: SP
authors.lastname: Allwein
authors.forename: Roger P
authors.initials: RP
authors.lastname: Bakale
mesh_terms: D015394:Molecular Structure; D016877:Oxidants / Q000737:chemistry; D010455:Peptides / Q000737:chemistry; D019606:Phosphoamino Acids / Q000138:chemical synthesis*
chemical_list: D016877:Oxidants; D010455:Peptides; D019606:Phosphoamino Acids