title: Combining biocatalysis and chemoselective chemistries for glycopeptide antibiotics modification.
abstract: Glycopeptide antibiotics are clinically important medicines to treat serious Gram-positive bacterial infections. The emergence of glycopeptide resistance among pathogens has motivated considerable interest in expanding structural diversity of glycopeptide to counteract resistance. The complex structure of glycopeptide poses substantial barriers to conventional chemical methods for structural modifications. By contrast, biochemical approaches have attracted great attention because ample biosynthetic information and sophisticated toolboxes have been made available to change reaction specificity through protein engineering, domain swapping, pathway engineering, addition of substrate analogs, and mutagenesis.
authors.affiliation: Genomics Research Center, Academia Sinica, Taipei 115, Taiwan. tlli@gate.sinica.edu.tw
authors.forename: Tsung-Lin
authors.initials: TL
authors.lastname: Li
authors.forename: Yu-Chen
authors.initials: YC
authors.lastname: Liu
authors.forename: Syue-Yi
authors.initials: SY
authors.lastname: Lyu
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000378:metabolism*; D055162:Biocatalysis; D006020:Glycopeptides / Q000737:chemistry / Q000378:metabolism*; D010084:Oxidation-Reduction
chemical_list: D000900:Anti-Bacterial Agents; D006020:Glycopeptides