title: Association of MBL2 gene exon 1 variants with autoimmune thyroid disease in Brazilian patients.
abstract: We investigated the association between MBL2 gene exon 1 functional polymorphisms and autoimmune thyroid disease (AITD) in 163 Brazilian patients (87 with Hashimoto thyroiditis, HT; 76 with Graves' disease) and 214 healthy controls. Individuals carrying MBL2 O allele are at higher risk of developing AITD (OR = 1.58, 95% CI: 1.11-2.26; P-value = 0.009) and HT (OR = 1.67, 95% CI: 1.09-2.55; P-value = 0.013) as suggesting a possible role for mannose-binding lectin in influencing disease susceptibility.
authors.affiliation: Internal Medicine's Unit of Otavio de Freitas's Hospital, Recife, Brazil.
authors.forename: C B
authors.initials: CB
authors.lastname: Filho
authors.forename: F F
authors.initials: FF
authors.lastname: Rodrigues
authors.forename: L
authors.initials: L
authors.lastname: Segat
authors.forename: A M
authors.initials: AM
authors.lastname: Fonseca
authors.forename: J
authors.initials: J
authors.lastname: Araujo
authors.forename: C
authors.initials: C
authors.lastname: Arahata
authors.forename: L
authors.initials: L
authors.lastname: Pontes
authors.forename: L
authors.initials: L
authors.lastname: Vilar
authors.forename: J L
authors.initials: JL
authors.lastname: de Lima Filho
authors.forename: S
authors.initials: S
authors.lastname: Crovella
mesh_terms: D000293:Adolescent; D000328:Adult; D001938:Brazil / Q000453:epidemiology; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005091:Exons; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006111:Graves Disease / Q000453:epidemiology / Q000235:genetics*; D050031:Hashimoto Disease / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D007223:Infant; D008297:Male; D037601:Mannose-Binding Lectin / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
chemical_list: C445619:MBL2 protein, human; D037601:Mannose-Binding Lectin