title: Is tumor size a reliable predictor of histopathological characteristics of renal cell carcinoma?
abstract: OBJECTIVE
  To determine whether smaller tumor size is associated with less-aggressiveness in renal cell carcinoma (RCC).
  
  
  METHODS
  Series records of 505 patients diagnosed with RCC were retrospectively reviewed and the data concerning tumor size and pathological information were extracted and analyzed.
  
  
  RESULTS
  Five hundred and eight RCCs were identified. The mean tumor size was 5.02 ± 2.70 cm. No correlation was detected between the size of tumor and the histological subtype. The overall nuclear grade distribution was 57.1% and 42.9% for low-grade and high-grade disease, respectively. Each 1 cm increase in tumor size was associated with a significant increase in the odds ratio of high-grade disease by 1.46. 91.1% were found low-stage lesions and the odds ratio for the association of high-stage disease with each 1 cm increase in tumor size was 1.67. Multinomial models revealed that each 1 cm increase in the tumor size was associated with a 35% increase in renal capsule involvement and 66% renal vascular invasion. The cut-off point of tumor size in renal vascular invasion was 5.6 cm.
  
  
  CONCLUSIONS
  Tumor size is not an independent predictor for the histological subtype of RCC. However, it is closely correlated to histopathological features, with the indications that the greater the tumor size, the more aggressive potential the RCC is.
authors.affiliation: Department of Urology, West China Hospital, Sichuan University, Guoxue Xiang, Chengdu, Sichuan, China.
authors.forename: Song
authors.initials: S
authors.lastname: Turun
authors.forename: Liao
authors.initials: L
authors.lastname: Banghua
authors.forename: Shuo
authors.initials: S
authors.lastname: Zheng
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wei