title: Inflammatory response patterns in ICSI patients: a comparative study between chronic anovulating and normally ovulating women.
abstract: The aim of this study was to evaluate inflammatory response in chronic anovulating infertility women undergoing intracytoplasmic sperm injection. Thirteen infertile women with chronic anovulation and 23 normally ovulating women were prospectively evaluated. N-acetylglucosaminidase (NAG), myeloperoxidase (MPO), monocyte chemoattractant protein 1 (MCP-1), and C-reactive protein (CRP) concentrations were evaluated in serum and follicular fluid. Women with chronic anovulation presented higher NAG and MPO activity in follicular fluid when compared with normally ovulating women. Serum MPO activity was higher in the control group compared to the chronic anovulation group. Both serum and follicular fluid CRP concentrations were higher in women with chronic anovulation in comparison with the control group. Higher MCP-1 follicular fluid concentrations and serum levels of CRP were associated with the occurrence of ovarian hyperstimulation syndrome. Patients with chronic anovulation exhibited significantly higher follicle macrophage/neutrophil activation as well as unspecific inflammatory response by comparison with normally ovulating women.
authors.affiliation: Department of Obstetrics and Gynecology of Paulista State University, Botucatu, SP, Brazil.
authors.forename: Rívia Mara
authors.initials: RM
authors.lastname: Lamaita
authors.forename: Anaglória
authors.initials: A
authors.lastname: Pontes
authors.forename: Andrezza V
authors.initials: AV
authors.lastname: Belo
authors.forename: João Pedro J
authors.initials: JP
authors.lastname: Caetano
authors.forename: Sílvia P
authors.initials: SP
authors.lastname: Andrade
authors.forename: Eduardo Batista
authors.initials: EB
authors.lastname: Cãndido
authors.forename: Paulo
authors.initials: P
authors.lastname: Traiman
authors.forename: Márcia Mendonça
authors.initials: MM
authors.lastname: Carneiro
authors.forename: Agnaldo L
authors.initials: AL
authors.lastname: Silva-Filho
mesh_terms: D000328:Adult; D000858:Anovulation / Q000097:blood / Q000276:immunology* / Q000378:metabolism / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D016022:Case-Control Studies; D005260:Female; D015571:Follicular Fluid / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000628:therapy*; D008262:Macrophage Activation; D018375:Neutrophil Activation; D011446:Prospective Studies; D020554:Sperm Injections, Intracytoplasmic; D055815:Young Adult
chemical_list: D015415:Biomarkers