title: Cytopathological features of cell suffering and death: Role of plasma membrane and cytoskeleton.
abstract: Morphological and ultrastructural modifications related to the cell injury and leading to cell death have been investigated by using different compounds. Data obtained by treating various cultured cells with a quinone (menadione), a polar solvent (NMF) and a bacterial protein toxin (toxin B fromClostridium difficile) are here reported Differences seem to exist between such injuries, but changes in plasma membrane structure, called surface blebbing phenomenon, represent a common feature which can be in any case detected. Our results also allow to hypothesize an important role of cytoskeleton in such a process.
authors.affiliation: Department of Ultrastructures, Istituto Superiore di Sanita, viale Regina Elena 299, 00161, Rome, Italy.
authors.forename: W
authors.initials: W
authors.lastname: Malorni
authors.forename: F
authors.initials: F
authors.lastname: Iosi
authors.forename: S
authors.initials: S
authors.lastname: Meschini
authors.forename: S
authors.initials: S
authors.lastname: Paradisi
authors.forename: G
authors.initials: G
authors.lastname: Donelli