title: A detour for yeast oxysterol binding proteins.
abstract: Oxysterol binding protein-related proteins, including the yeast proteins encoded by the OSH gene family (OSH1-OSH7), are implicated in the non-vesicular transfer of sterols between intracellular membranes and the plasma membrane. In light of recent studies, we revisited the proposal that Osh proteins are sterol transfer proteins and present new models consistent with known Osh protein functions. These models focus on the role of Osh proteins as sterol-dependent regulators of phosphoinositide and sphingolipid pathways. In contrast to their posited role as non-vesicular sterol transfer proteins, we propose that Osh proteins coordinate lipid signaling and membrane reorganization with the assembly of tethering complexes to promote molecular exchanges at membrane contact sites.
authors.affiliation: Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia V5A 1S6, Canada. ctbeh@sfu.ca
authors.forename: Christopher T
authors.initials: CT
authors.lastname: Beh
authors.forename: Christopher R
authors.initials: CR
authors.lastname: McMaster
authors.forename: Keith G
authors.initials: KG
authors.lastname: Kozminski
authors.forename: Anant K
authors.initials: AK
authors.lastname: Menon
mesh_terms: D002462:Cell Membrane / Q000378:metabolism; D005656:Fungal Proteins / Q000737:chemistry / Q000378:metabolism*; D008563:Membrane Lipids / Q000378:metabolism; D011987:Receptors, Steroid / Q000737:chemistry / Q000378:metabolism*; D015003:Yeasts / Q000166:cytology / Q000378:metabolism*; D000098825:Oxysterol Binding Proteins
chemical_list: D005656:Fungal Proteins; D008563:Membrane Lipids; D011987:Receptors, Steroid; D000098825:Oxysterol Binding Proteins