title: Plasma proteomic profiling in HIV-1 infected methamphetamine abusers.
abstract: We wanted to determine whether methamphetamine use affects a subset of plasma proteins in HIV-infected persons. Plasma samples from two visits were identified for subjects from four groups: HIV+, ongoing, persistent METH use; HIV+, short-term METH abstinent; HIV+, long term METH abstinence; HIV negative, no history of METH use. Among 390 proteins identified, 28 showed significant changes in expression in the HIV+/persistent METH+ group over the two visits, which were not attributable to HIV itself. These proteins were involved in complement, coagulation pathways and oxidative stress. Continuous METH use is an unstable condition, altering levels of a number of plasma proteins.
authors.affiliation: Department of Pharmacology and Experimental Neuroscience, Omaha, Nebraska, United States of America.
authors.forename: Gwenael
authors.initials: G
authors.lastname: Pottiez
authors.forename: Teena
authors.initials: T
authors.lastname: Jagadish
authors.forename: Fang
authors.initials: F
authors.lastname: Yu
authors.forename: Scott
authors.initials: S
authors.lastname: Letendre
authors.forename: Ronald
authors.initials: R
authors.lastname: Ellis
authors.forename: Nichole A
authors.initials: NA
authors.lastname: Duarte
authors.forename: Igor
authors.initials: I
authors.lastname: Grant
authors.forename: Howard E
authors.initials: HE
authors.lastname: Gendelman
authors.forename: Howard S
authors.initials: HS
authors.lastname: Fox
authors.forename: Pawel
authors.initials: P
authors.lastname: Ciborowski
mesh_terms: D001777:Blood Coagulation; D001798:Blood Proteins / Q000032:analysis*; D003165:Complement System Proteins; D015658:HIV Infections / Q000097:blood* / Q000150:complications; D015497:HIV-1; D006801:Humans; D008694:Methamphetamine / Q000494:pharmacology*; D018384:Oxidative Stress; D040901:Proteomics; D019966:Substance-Related Disorders / Q000097:blood* / Q000150:complications
chemical_list: D001798:Blood Proteins; D008694:Methamphetamine; D003165:Complement System Proteins