title: One-pot synthesis of 1-alkyl-1H-indazoles from 1,1-dialkylhydrazones via aryne annulation.
abstract: The reaction of readily accessible 1,1-dialkylhydrazones with commercially available o-(trimethylsilyl)aryl triflates provides a direct one-step route to pharmaceutically important 1-alkylindazoles. The products are obtained in high yields by one-pot NCS-chlorination/aryne annulation or Ac(2)O-acylation/deprotection/aromatization protocols.
authors.affiliation: Department of Chemistry, Iowa State University, Ames, IA 50011, USA.
authors.forename: Nataliya A
authors.initials: NA
authors.lastname: Markina
authors.forename: Anton V
authors.initials: AV
authors.lastname: Dubrovskiy
authors.forename: Richard C
authors.initials: RC
authors.lastname: Larock
mesh_terms: D000478:Alkylation; D003500:Cyclization; D006835:Hydrazones / Q000737:chemistry*; D007191:Indazoles / Q000138:chemical synthesis*; D015394:Molecular Structure
chemical_list: D006835:Hydrazones; D007191:Indazoles