title: Novel hepatitis C virus replicon inhibitors: synthesis and structure-activity relationships of fused pyrimidine derivatives.
abstract: The synthesis of several pyrido[2,3-d]pyrimidine and pyrimido[4,5-d]pyrimidine analogs is described with one such analog possessing subnanomolar potency in both genotype 1a and 1b cell culture HCV replicon assays.
authors.affiliation: Abbott Labs, Global Pharmaceutical Research and Development, Abbott Park, IL 60064, USA. a.chris.krueger@abbott.com
authors.forename: A Chris
authors.initials: AC
authors.lastname: Krueger
authors.forename: Darold L
authors.initials: DL
authors.lastname: Madigan
authors.forename: David W
authors.initials: DW
authors.lastname: Beno
authors.forename: David A
authors.initials: DA
authors.lastname: Betebenner
authors.forename: Robert
authors.initials: R
authors.lastname: Carrick
authors.forename: Brian E
authors.initials: BE
authors.lastname: Green
authors.forename: Wenping
authors.initials: W
authors.lastname: He
authors.forename: Dachun
authors.initials: D
authors.lastname: Liu
authors.forename: Clarence J
authors.initials: CJ
authors.lastname: Maring
authors.forename: Keith F
authors.initials: KF
authors.lastname: McDaniel
authors.forename: Hongmei
authors.initials: H
authors.lastname: Mo
authors.forename: Akhteruzzaman
authors.initials: A
authors.lastname: Molla
authors.forename: Christopher E
authors.initials: CE
authors.lastname: Motter
authors.forename: Tami J
authors.initials: TJ
authors.lastname: Pilot-Matias
authors.forename: Michael D
authors.initials: MD
authors.lastname: Tufano
authors.forename: Dale J
authors.initials: DJ
authors.lastname: Kempf
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D005838:Genotype; D016174:Hepacivirus / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D012367:RNA, Viral / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D012093:Replicon / Q000187:drug effects; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D011743:Pyrimidines; D012367:RNA, Viral