title: Diversity of metabotropic glutamate receptor-interacting proteins and pathophysiological functions.
abstract: In the mammalian brain, the large majority of excitatory synapses express pre- and postsynaptic glutamate receptors. These are ion channels and G protein-coupled membrane proteins that are organized into functional signaling complexes. Here, we will review the nature and pathophysiological functions of the scaffolding proteins associated to these receptors, focusing on the G protein-coupled subtypes.
authors.affiliation: Institute of Functional Genomics, CNRS-UMR5203, INSERM-U661, Université Montpellier 1, Université Montpellier 2, 141 Rue de la Cardonille, 34000 Montpellier, France. laurent.fagni@igf.cnrs.fr
authors.forename: Laurent
authors.initials: L
authors.lastname: Fagni
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000235:genetics / Q000378:metabolism; D018740:Genetic Heterogeneity; D018698:Glutamic Acid / Q000378:metabolism; D000072233:Homer Scaffolding Proteins; D006801:Humans; D008322:Mammals; D001523:Mental Disorders / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D051379:Mice; D019636:Neurodegenerative Diseases / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D009474:Neurons / Q000502:physiology; D057907:Post-Synaptic Density / Q000235:genetics / Q000378:metabolism*; D011485:Protein Binding; D018094:Receptors, Metabotropic Glutamate / Q000235:genetics / Q000378:metabolism*; D009435:Synaptic Transmission / Q000502:physiology*
chemical_list: D002352:Carrier Proteins; D000072233:Homer Scaffolding Proteins; D018094:Receptors, Metabotropic Glutamate; D018698:Glutamic Acid; D019204:GTP-Binding Proteins