title: How reggies regulate regeneration and axon growth.
abstract: The microdomain-forming proteins reggie-1 and reggie-2 (alias flotillins) were found to be upregulated in axon-regenerating fish retinal ganglion cells (RGCs). They were subsequently shown to be indispensible for axon regeneration and neurite extension in fish and mammals. Our current concept proposes that reggies--often together with the cellular Prion protein (PrP)--regulate the turnover of membrane and specific membrane proteins at the growth cone, which is the prerequisite for neurite elongation and guidance.
authors.affiliation: Department of Biology, University of Konstanz, 78467 Konstanz, Germany. claudia.stuermer@uni-konstanz.de
authors.forename: Claudia A O
authors.initials: CA
authors.lastname: Stuermer
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology*; D006801:Humans; D008247:Lysosomes / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism*; D009416:Nerve Regeneration / Q000502:physiology*; D012165:Retinal Ganglion Cells / Q000378:metabolism; D022161:Transport Vesicles / Q000378:metabolism
chemical_list: D008565:Membrane Proteins; C106354:flotillins