title: [Comparative effects of low and medium molecular hydroxyethyl starch (HES) solutions on hemorrhagic shock in rats].
abstract: BACKGROUND
  Hydroxyethyl starch (HES) solutions are frequently used plasma expanders. We examined the effects of medium-HES (mean molecular weight of 130,000 dalton) and low-HES (mean molecular weight of 70,000 dalton) on the survival rates (Exp. I), colloid osmotic pressure (COP) (Exp. II) and coagulation (Exp. III) with rats in hemorrhagic shock.
  
  
  METHODS
  Hemorrhagic shock was induced by removing 55% (Exp. I) and 20% (Exp. II and III) of the circulating blood volume. Saline, low-HES or medium-HES of the same volume with the removed blood was intravenously infused immediately after bleeding.
  
  
  RESULTS
  Exp. I: In survival rate, effect of medium-HES was significantly superior to that of saline. Exp. II: The COP of medium-HES group was significantly higher than that of saline group 3 hrs after hemorrhagic shock. Exp. III: There were no changes in von Willerbrand factor and factor VIII 3 hrs after hemorrhagic shock among saline, low-HES and medium-HES.
  
  
  CONCLUSIONS
  Medium-HES and low-HES are efficacious plasma volume substitutes; however, the ability of medium-HES to prolong maintenance of COP better than low-HES is a finding that would be significant in a clinical setting involving preoperative blood management and extreme blood loss.
authors.affiliation: Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, Tokyo 142-8501.
authors.forename: Maki
authors.initials: M
authors.lastname: Yoneko
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Jun
authors.initials: J
authors.lastname: Kojima
mesh_terms: D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D004195:Disease Models, Animal; D006895:Hydroxyethyl Starch Derivatives / Q000627:therapeutic use*; D008297:Male; D008970:Molecular Weight; D009997:Osmotic Pressure / Q000187:drug effects; D010952:Plasma Substitutes / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012771:Shock, Hemorrhagic / Q000097:blood / Q000188:drug therapy* / Q000401:mortality; D012996:Solutions; D015996:Survival Rate
chemical_list: D006895:Hydroxyethyl Starch Derivatives; D010952:Plasma Substitutes; D012996:Solutions