title: Multiple roles of STAT3 in cardiovascular inflammatory responses.
abstract: Cardiovascular inflammation has been regarded as a major cause for heart failure. However, the mechanisms that are involved in the regulation of cardiovascular inflammation are not well understood. In this chapter, we review the recent progress in revealing the roles of STAT3 in cardiovascular inflammation. Particularly, we discuss cardiomyocyte-specific STAT3-deficient mice and their phenotypes. An emerging view is that STAT3 plays a key role not only in cardiac protection but also in the control of cardiac-related inflammation.
authors.affiliation: Department of Biochemistry, National University of Singapore, Singapore.
authors.forename: Cheh Peng
authors.initials: CP
authors.lastname: Lim
authors.forename: Xin-Yuan
authors.initials: XY
authors.lastname: Fu
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000378:metabolism / Q000503:physiopathology*; D050822:Cytokine Receptor gp130 / Q000502:physiology; D016207:Cytokines / Q000502:physiology; D042783:Endothelial Cells / Q000378:metabolism; D005786:Gene Expression Regulation; D006333:Heart Failure / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D007249:Inflammation; D015850:Interleukin-6 / Q000502:physiology; D051379:Mice; D008822:Mice, Transgenic; D008955:Models, Cardiovascular; D017202:Myocardial Ischemia / Q000503:physiopathology; D032383:Myocytes, Cardiac / Q000378:metabolism; D010750:Phosphoproteins / Q000378:metabolism; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D051381:Rats; D050796:STAT3 Transcription Factor / Q000172:deficiency / Q000235:genetics* / Q000502:physiology*; D015398:Signal Transduction
chemical_list: D016207:Cytokines; C494199:IL6ST protein, human; D015850:Interleukin-6; D010750:Phosphoproteins; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human; C494087:Stat3 protein, mouse; D050822:Cytokine Receptor gp130