title: Parasites and malignancies, a review, with emphasis on digestive cancer induced by Cryptosporidium parvum (Alveolata: Apicomplexa).
abstract: The International Agency for Research on Cancer (IARC) identifies ten infectious agents (viruses, bacteria, parasites) able to induce cancer disease in humans. Among parasites, a carcinogenic role is currently recognized to the digenetic trematodes Schistosoma haematobium, leading to bladder cancer, and to Clonorchis sinensis or Opisthorchis viverrini, which cause cholangiocarcinoma. Furthermore, several reports suspected the potential association of other parasitic infections (due to Protozoan or Metazoan parasites) with the development of neoplastic changes in the host tissues. The present work shortly reviewed available data on the involvement of parasites in neoplastic processes in humans or animals, and especially focused on the carcinogenic power of Cryptosporidium parvum infection. On the whole, infection seems to play a crucial role in the etiology of cancer.
authors.affiliation: Biologie & Diversité des Pathogènes Eucaryotes Émergents (BDEEP), Centre d'Infection et d'Immunité de Lille (CIIL), INSERM U1019, CNRS UMR8402, EA4547, Université Lille Nord-de-France, Institut Pasteur de Lille, France.
authors.forename: S
authors.initials: S
authors.lastname: Benamrouz
authors.forename: V
authors.initials: V
authors.lastname: Conseil
authors.forename: C
authors.initials: C
authors.lastname: Creusy
authors.forename: E
authors.initials: E
authors.lastname: Calderon
authors.forename: E
authors.initials: E
authors.lastname: Dei-Cas
authors.forename: G
authors.initials: G
authors.lastname: Certad
mesh_terms: D000818:Animals; D003457:Cryptosporidiosis / Q000150:complications; D005770:Gastrointestinal Neoplasms / Q000469:parasitology; D006801:Humans; D009369:Neoplasms / Q000469:parasitology*; D011528:Protozoan Infections / Q000150:complications*; D014201:Trematode Infections / Q000150:complications*