title: [The modern approach in surgical treatment of skull base tumors in experience of neurotraumatology Department, Jagiellonian University Collegium Medicum from years 2003-2006].
abstract: OBJECTIVE
  The aim of this study was to evaluate the impact of modern methods in surgical treatment of skull base tumors (multidisciplinary operating teams, new methods of dura and bone defects repair) on extension of tumor resection considering complications rate.
  
  
  METHODS
  The retrospective study for 26 patients of Neurotraumatology Department, Jagiellonian University Collegium Medicum was carried out. All of patients were operated due to skull base tumor in period 2003 - 2006. In our series 9 patients (34.62%) was admitted with recurrence of skull base pathology. The age average for the sample was 57.38 +/- 14.84 years.
  
  
  RESULTS
  In 16 cases (61.54%) dura was involved in pathological process. Every time if dura resection was performed, the resulting defect was repaired with Tachocomb, tissue glue, artificial meninge, fascia lata femoris, pericranium. In case of bone infiltration (especially in anterior fossa of the skull), the resection was followed by the cranioplasty (Norian, cranioplast) - prevention of brain herniation, and opened during the operation sinuses were closed with use of temporal muscle and biomaterials. 15 patients (57.69%) were operated in mixed multidisciplinary teams (cooperation with Maxillofacial Surgery and Otorhinolaryngology Department). The resection of pathological mass was evaluated as completed in 69.23% (n=18) cases. The most common histopathological finding was neoplasm from meninges: 11 (42.31%) and epithelial neoplasm 7 (26.92%).
  
  
  CONCLUSIONS
  The modern micro- and neurosurgical techniques, new reconstructive methods of dura and bone defects (biomaterials) and multidisciplinary operating teams (craniofacial approach) diminished limitations for extended resection of tumors in very complexed area that skull base is, by complications on accepted level. Typical for skull base tumors' treatment is varied histopathological nature of mass lesions, what in relation to grading of tumors still has the strongest impact on long term results of treatment.
authors.affiliation: Klinika Neurochirurgii i Neurotraumatologii UJ CM w Krakowie. nt@cm-uj.krakow.pl
authors.forename: Marek
authors.initials: M
authors.lastname: Moskała
authors.forename: Jarosław
authors.initials: J
authors.lastname: Polak
authors.forename: Ewelina
authors.initials: E
authors.lastname: Grzywna
authors.forename: Tomasz
authors.initials: T
authors.lastname: Składzień
mesh_terms: D001672:Biocompatible Materials; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000601:surgery*; D011044:Poland; D019651:Plastic Surgery Procedures; D012189:Retrospective Studies; D019292:Skull Base Neoplasms / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D001672:Biocompatible Materials