title: A review on various targeted anticancer therapies.
abstract: Translational oncology aims to translate laboratory research into new anticancer therapies. Contrary to conventional surgery, chemotherapy, and radiotherapy, targeted anticancer therapy (TAT) refers to systemic administration of drugs with particular mechanisms that specifically act on well-defined targets or biologic pathways that, when activated or inactivated, may cause regression or destruction of the malignant process, meanwhile with minimized adverse effects on healthy tissues. In this article, we intend to first give a brief review on various known TAT approaches that are deemed promising for clinical applications in the current trend of personalized medicine, and then we will introduce our newly developed approach namely small molecular sequential dual targeting theragnostic strategy as a generalized class of TAT for the management of most solid malignancies, which, after optimization, is expected to help improve overall cancer treatability and curability.
authors.affiliation: Section of Radiology, Department of Diagnostic Sciences, Faculty of Medicine, University of Leuven, Herestraat 49, BE-3000, Leuven, Belgium.
authors.forename: Junjie
authors.initials: J
authors.lastname: Li
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
authors.forename: Marlein Miranda
authors.initials: MM
authors.lastname: Cona
authors.forename: Yuanbo
authors.initials: Y
authors.lastname: Feng
authors.forename: Uwe
authors.initials: U
authors.lastname: Himmelreich
authors.forename: Raymond
authors.initials: R
authors.lastname: Oyen
authors.forename: Alfons
authors.initials: A
authors.lastname: Verbruggen
authors.forename: Yicheng
authors.initials: Y
authors.lastname: Ni
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000145:classification* / Q000627:therapeutic use*; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods*; D009369:Neoplasms / Q000188:drug therapy*; D057285:Precision Medicine; D015398:Signal Transduction; D054852:Small Molecule Libraries
chemical_list: D000970:Antineoplastic Agents; D054852:Small Molecule Libraries