title: [Protective effects of garlic oil on n-hexane-induced neurotoxicity in rats via inhibition of hepatic alcohol dehydrogenase activity].
abstract: OBJECTIVE
  To study the protective effects of garlic oil (GO) on the peripheral nerve injuries induced by n-hexane.
  
  
  METHODS
  Male Wistar rats were randomly divided into four groups (10 rats in each group): the control, the n-hexane treatment (2000 mg/kg), the low dose GO, and the high dose GO groups. The rats in the low and high doses of GO groups were pretreated with GO (40 and 80 mg/kg) before exposure to n-hexane (2000 mg/ kg), while the animals of the n-hexane treatment group were given normal saline and then 2000 mg/ kg n-hexane. The rats were exposed to GO and n-hexane 6 times a week for 10 weeks. The gait scores and staying time on the rotating rod for all rats were detected every two weeks. The rats were sacrificed at the end of ten weeks, then the levels of alcohol dehydrogenase (ADH), maleic dialdehyde (MDA), reduced glutathione (GSH), glutathione peroxidase(GSH-Px), total antioxidation capacity(T-AOC) and the ability of inhibition of *OH in livers were examined.
  
  
  RESULTS
  The gait scores increased significantly and the time staying on the rotating rod obviously decreased in rats of n-hexane treatment group, as compared with control group (P < 0.05 or P < 0.01). In the hepatic tissues of n-hexane group, the levels of MDA and ADH significantly increased, the activities of GSH-Px, T-AOC and the ability of inhibition of *OH obviously decreased, as compared to control group (P < 0.05 or P < 0.01). In 2 GO groups, the gait scores and the staying time on the rotating rod were significantly improved, the levels of MDA and ADH significantly decreased, the activities of GSH-Px, T-AOC and the ability of inhibition of *OH obviously increased, as compared with n-hexane group (P < 0.05 or P < 0.01 ).
  
  
  CONCLUSIONS
  ADH could play an important role in the protective effects induced by garlic oil on the peripheral nerve injuries produced by n-hexane.
authors.affiliation: Institute of Toxicology, School of Public Health, Shandong University, Jinan, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Bi
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Chen
authors.forename: Jie
authors.initials: J
authors.lastname: Yan
authors.forename: Tao
authors.initials: T
authors.lastname: Zeng
authors.forename: Qiang-Qiang
authors.initials: QQ
authors.lastname: Fu
authors.forename: Zhi-Xia
authors.initials: ZX
authors.lastname: Zhong
authors.forename: Ke-Qin
authors.initials: KQ
authors.lastname: Xie
mesh_terms: D000426:Alcohol Dehydrogenase / Q000378:metabolism*; D000818:Animals; D005737:Garlic; D006586:Hexanes / Q000633:toxicity*; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology*; D059348:Peripheral Nerve Injuries / Q000139:chemically induced* / Q000378:metabolism; D010938:Plant Oils / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D006586:Hexanes; D018696:Neuroprotective Agents; D010938:Plant Oils; C026385:n-hexane; D000426:Alcohol Dehydrogenase