title: Adhesion molecules in cancer of the head and neck: role of dysadherin.
abstract: Dysadherin is a recently discovered cancer-related cell membrane glycoprotein that has an important role in tumor progression and metastasis. We are focusing on the role of dysadherin in E-cadherin downregulation, the different expression patterns of the molecule in cancer of the head and neck and its potential role as a molecular target for future applications in diagnosis, prognosis, and management of the disease.
authors.affiliation: ENT Department, University of Athens, Hippokrateion Hospital, Athens, Greece.
authors.forename: I
authors.initials: I
authors.lastname: Giotakis
authors.forename: A
authors.initials: A
authors.lastname: Chrysovergis
authors.forename: A
authors.initials: A
authors.lastname: Georgolios
authors.forename: E
authors.initials: E
authors.lastname: Giotakis
authors.forename: L
authors.initials: L
authors.lastname: Manolopoulos
mesh_terms: D015820:Cadherins / Q000096:biosynthesis / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D002448:Cell Adhesion / Q000502:physiology; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D005260:Female; D006258:Head and Neck Neoplasms / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007473:Ion Channels; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism*; D008840:Microfilament Proteins; D009363:Neoplasm Proteins / Q000378:metabolism*
chemical_list: D015820:Cadherins; D015815:Cell Adhesion Molecules; C451410:FXYD5 protein, human; D007473:Ion Channels; D008562:Membrane Glycoproteins; D008840:Microfilament Proteins; D009363:Neoplasm Proteins