title: Immunolocalization of vascular adhesion protein-1 in human conjunctival tumors.
abstract: OBJECTIVE
  We analyzed the expression and immunolocalization of vascular adhesion protein (VAP)-1 in conjunctival tumors and normal conjunctival tissue of humans.
  
  
  METHODS
  Nine conjunctival tumors, including pyogenic granuloma and extranodal marginal zone B-cell lymphoma (EMZL), and 2 normal conjunctivas were analyzed by immunohistochemistry for VAP-1 and CD31 expression.
  
  
  RESULTS
  Immunoreactivity for VAP-1 was detected in the lumen of microvessels in pyogenic granuloma and in EMZLs. In contrast, normal bulbar conjunctival tissues demonstrated weak cytoplasmic immunoreactivity for VAP-1 in the blood vessels.
  
  
  CONCLUSIONS
  The immunolocalization of VAP-1 varied in the histopathology of the conjunctiva, involving the pathology of inflammatory conjunctival disorders.
authors.affiliation: Laboratory of Ocular Cell Biology and Visual Science, Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
authors.forename: Junichi
authors.initials: J
authors.lastname: Fukuhara
authors.forename: Satoru
authors.initials: S
authors.lastname: Kase
authors.forename: Kousuke
authors.initials: K
authors.lastname: Noda
authors.forename: Miyuki
authors.initials: M
authors.lastname: Murata
authors.forename: Mika
authors.initials: M
authors.lastname: Noda
authors.forename: Ryo
authors.initials: R
authors.lastname: Ando
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Dong
authors.forename: Atsuhiro
authors.initials: A
authors.lastname: Kanda
authors.forename: Susumu
authors.initials: S
authors.lastname: Ishida
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006631:Amine Oxidase (Copper-Containing) / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D015153:Blotting, Western; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D003228:Conjunctiva / Q000098:blood supply / Q000378:metabolism; D003230:Conjunctival Neoplasms / Q000098:blood supply / Q000378:metabolism*; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D017789:Granuloma, Pyogenic / Q000378:metabolism; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism*; D009389:Neovascularization, Pathologic / Q000378:metabolism; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D015815:Cell Adhesion Molecules; D009363:Neoplasm Proteins; D019408:Platelet Endothelial Cell Adhesion Molecule-1; C076668:AOC3 protein, human; D006631:Amine Oxidase (Copper-Containing)