title: [Expression of matrix metalloproteinase 1 in tissue of colon carcinoma and its clinical prognostic significance].
abstract: OBJECTIVE
  To explore the expression patterns of matrix metalloproteinase1 (MMP-1) in colon carcinoma and evaluate its clinical significance.
  
  
  METHODS
  The expression of MMP-1 was detected by SP immunohistochemical method. The tissue microarray samples of 620 colon carcinoma patients were collected and the clinical data reviewed.
  
  
  RESULTS
  The positive expression rate of MMP-1 in cancer tissue was higher than that of normal tissue [72.5% (421/581) vs 30.8% (179/581), P = 0.0001]. And the difference was statistically significant (P = 0.0001). The positive rate in stages I and II [77.6% (235/303)] were higher than stages III and IV [66.9% (186/278), P = 0.0040], the former two stages showed a poor prognosis while the latter two stages a fair prognosis. The results of COX regression showed that a lower expression of MMP-1 (HR: 1.042, 95%CI: 0.770 - 1.410, P = 0.0001), tumor type (HR: 0.966, 95%CI: 0.571 - 1.633, P = 0.0150), local infiltration (HR: 0.576, 95%CI: 0.413 - 0.805, P = 0.0010) and infiltration of bowel wall (HR: 0.337, 95%CI: 0.197 - 0.575, P = 0.0001) were significant predictors of colon carcinoma.
  
  
  CONCLUSIONS
  As an independent prognostic factor of colon carcinoma, the expression of MMP-1 in cancer tissue has different prognostic implications according to various stages.
authors.affiliation: Department of Colorectal Surgery, Sun Yat-sen University, Guangzhou, China.
authors.forename: Zhen-hai
authors.initials: ZH
authors.lastname: Lu
authors.forename: Yu-jing
authors.initials: YJ
authors.lastname: Fang
authors.forename: Xiao-jun
authors.initials: XJ
authors.lastname: Wu
authors.forename: Zhi-zhong
authors.initials: ZZ
authors.lastname: Pan
authors.forename: De-sen
authors.initials: DS
authors.lastname: Wan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D003110:Colonic Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D020781:Matrix Metalloproteinase 1 / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D015996:Survival Rate; D055815:Young Adult
chemical_list: C522360:MMP1 protein, human; D020781:Matrix Metalloproteinase 1