title: Structural and functional characteristics and properties of metzincins.
abstract: In this review the main families of endopeptidases belonging to the clan of metzincins of zinc-dependent metalloproteinases in organisms of wide evolutional range from bacteria to mammals are considered. The data on classification, physicochemical properties, substrate specificity, and structural features of this group of enzymes are given. The activation mechanisms of metzincins, the role of these proteins in organisms, and their participation in various physiological processes are discussed.
authors.affiliation: Kazan Federal University, Kazan, Russia.
authors.forename: N P
authors.initials: NP
authors.lastname: Balaban
authors.forename: N L
authors.initials: NL
authors.lastname: Rudakova
authors.forename: M R
authors.initials: MR
authors.lastname: Sharipova
mesh_terms: D020816:Amino Acid Motifs; D001665:Binding Sites; D020134:Catalytic Domain; D008666:Metalloendopeptidases / Q000737:chemistry* / Q000145:classification / Q000378:metabolism; D015032:Zinc / Q000737:chemistry / Q000378:metabolism
chemical_list: D008666:Metalloendopeptidases; D015032:Zinc