title: Treatment of white spot lesions with ACP paste and microabrasion.
abstract: OBJECTIVE
  To examine the effects of application of casein phosphopeptide amorphous calcium phosphate (CPP-ACP) paste and microabrasion treatment on the regression of white spot lesions (WSLs).
  
  
  METHODS
  Artificially-induced WSLs in bovine enamel were randomly assigned to one of four treatment groups: CPP-ACP paste only, microabrasion only, microabrasion and CPP-ACP, and a control. Samples were treated with each regimen twice daily for 2 weeks and stored in remineralizing solution between the treatments. Quantitative light-induced fluorescence was used to measure changes in fluorescence, which indicate changes in mineral content of WSLs immediately before (T1) and 2 weeks after treatment (T2). A two-within-subject factor analysis of variance was used to analyze the significance of any changes in mineral content of the lesions from T1 to T2.
  
  
  RESULTS
  There was a statistically significant (P < .05) gain in fluorescence associated with the microabrasion only, as well as the microabrasion and CPP-ACP treatments. The changes in fluorescence for the CPP-ACP treatment alone were not statistically significant (P  =  .40).
  
  
  CONCLUSIONS
  CPP-ACP paste alone does not significantly improve the fluorescence value (ie, the mineral content) of WSLs. Within the limitations of this in vitro study, microabrasion treatment with or without CPP-ACP improved the fluorescence and thus reduced WSLs.
authors.affiliation: Division of Orthodontics, Faculty of Dentistry, University of British Columbia, Vancouver, British Columbia, Canada. pliska@dentistry.ubc.ca
authors.forename: Benjamin T
authors.initials: BT
authors.lastname: Pliska
authors.forename: Gary A
authors.initials: GA
authors.lastname: Warner
authors.forename: Daranee
authors.initials: D
authors.lastname: Tantbirojn
authors.forename: Brent E
authors.initials: BE
authors.lastname: Larson
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D002327:Cariostatic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002364:Caseins / Q000494:pharmacology* / Q000627:therapeutic use; D002417:Cattle; D003731:Dental Caries / Q000139:chemically induced / Q000628:therapy*; D003743:Dental Enamel / Q000187:drug effects*; D019243:Enamel Microabrasion; D014089:Tooth Remineralization / Q000379:methods*
chemical_list: D002327:Cariostatic Agents; D002364:Caseins; C447032:casein phosphopeptide-amorphous calcium phosphate nanocomplex