title: Cardioprotective effect of curcumin against doxorubicin-induced myocardial toxicity in albino rats.
abstract: OBJECTIVE
  To study the preventive role of curcumin against doxorubicin (Dox)-induced myocardial toxicity in rats.
  
  
  METHODS
  Cardiotoxicity was produced by cumulative administration of Dox (15 mg/kg for two weeks). Curcumin (200 mg/kg, po) was administered as pretreatment for two weeks and then for two alternate weeks with Dox. The general observations, mortality, histopathology, biomarker enzymes like lactate dehydrogenase (LDH) and creatine phosphokinase (CPK), biochemical parameters such as aspartate aminotransferase (AST) alanine aminotransferase (ALT) and alkaline phosphatase (ALP), antioxidant enzymes such as glutathione (GSH), superoxide dismutase (SOD) and catalase (CAT) were monitored after three weeks of last dose.
  
  
  RESULTS
  The repeated administration of Dox induced cardiomyopathy associated with an antioxidant deficit and increased level biomarkers. Pretreatment with the curcumin significantly protected myocardium from the toxic effects of Dox by reducing the elevated level of biomarker enzymes like LDH and CPK and biochemical parameters such as AST, ALT and ALP back to normal. Curcumin increased the reduced level of GSH, SOD and CAT and decreased the elevated level of malondialdehyde (MDA) in cardiac tissue.
  
  
  CONCLUSIONS
  The biochemical and histopathology reports support the cardioprotective effect of curcumin which could be attributed to antioxidant.
authors.affiliation: Department of Pharmacology, K.L.E. Society's College of Pharmacy, Hubli, India.
authors.forename: Agadihiremath Vishwanatha
authors.initials: AV
authors.lastname: Swamy
authors.forename: Sumeet
authors.initials: S
authors.lastname: Gulliaya
authors.forename: Agadihiremath
authors.initials: A
authors.lastname: Thippeswamy
authors.forename: Basavaraj C
authors.initials: BC
authors.lastname: Koti
authors.forename: Donnahalli V
authors.initials: DV
authors.lastname: Manjula