title: Inflammatory bowel disease manifesting after surgical treatment for Hirschsprung disease.
abstract: Eight children developed chronic inflammatory bowel disease (IBD) 4 to 21 years after surgery for Hirschsprung disease. Three had trisomy 21 and 6 experienced chronic or recurrent enterocolitis. Four had a family history of IBD. Clinical presentation included chronic diarrhea, hematochezia, abscess, and fistula formation. Three required surgery for fistula, stricture, and small bowel obstruction and the other 5 were managed medically. Recognition of this condition may be important in the long-term follow-up of children with Hirschsprung disease, and patients who have carried a diagnosis of chronic enterocolitis may warrant further investigation looking for evidence of IBD.
authors.affiliation: Division of General and Thoracic Surgery, Hospital for Sick Children, Toronto, Canada.
authors.forename: David N
authors.initials: DN
authors.lastname: Levin
authors.forename: Margaret A
authors.initials: MA
authors.lastname: Marcon
authors.forename: Risto J
authors.initials: RJ
authors.lastname: Rintala
authors.forename: Dustin
authors.initials: D
authors.lastname: Jacobson
authors.forename: Jacob C
authors.initials: JC
authors.lastname: Langer
mesh_terms: D000038:Abscess / Q000209:etiology; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D003967:Diarrhea / Q000209:etiology; D004314:Down Syndrome; D004760:Enterocolitis / Q000209:etiology; D005260:Female; D005402:Fistula / Q000209:etiology / Q000601:surgery; D006471:Gastrointestinal Hemorrhage / Q000209:etiology; D006627:Hirschsprung Disease / Q000150:complications / Q000601:surgery; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D015212:Inflammatory Bowel Diseases / Q000209:etiology; D007415:Intestinal Obstruction / Q000209:etiology; D007421:Intestine, Small / Q000473:pathology; D008297:Male