title: Early outcomes after extracardiac conduit Fontan operation without cardiopulmonary bypass.
abstract: Cardiopulmonary bypass is associated with a systemic inflammatory response. The authors hypothesized that avoiding cardiopulmonary bypass would lead to improved postoperative outcomes for patients undergoing the extracardiac Fontan operation, the final stage in surgical palliation of univentricular congenital heart defects. A review of the Children's Heart Center Database showed a total of 73 patients who underwent an initial Fontan operation at Lucile Packard Children's Hospital at Stanford between 1 November 2001 and 1 November 2006. These patients were divided into two groups: those who underwent cardiopulmonary bypass (n = 26) and those who avoided cardiopulmonary bypass (n = 47). Preoperative demographics, hemodynamics, and early postoperative outcomes were analyzed. The two groups had comparable preoperative demographic characteristics and hemodynamics except that the average weight of the off-bypass group was greater (17.9 ± 9.1 vs 14.2 ± 2.7 kg; P = 0.01). Intraoperatively, the off-bypass group trended toward a lower rate of Fontan fenestration (4.3 vs 19.2%; P = 0.09), had lower common atrial pressures (4.6 ± 1.4 vs 5.5 ± 1.5 mmHg; P = 0.05), and Fontan pressures (11.9 ± 2.1 vs 14.2 ± 2.4 mmHg; P ≤ 0.01), and required less blood product (59.1 ± 37.6 vs 91.9 ± 49.4 ml/kg; P ≤ 0.01). Postoperatively, there were no significant differences in hemodynamic parameters, postoperative colloid requirements, duration of mechanical ventilation, volume or duration of pleural drainage, or duration of cardiovascular intensive care unit or hospital stay. Avoiding cardiopulmonary bypass influenced intraoperative hemodynamics and the incidence of fenestration but did not have a significant impact on the early postoperative outcomes of children undergoing the Fontan procedure.
authors.affiliation: Department of Pediatrics, Doernbecher Children's Hospital, Oregon Health & Science University, 707 SW Gaines Road, CDRC-P, Portland, OR 97239, USA. mccammoa@ohsu.edu
authors.forename: Amy N
authors.initials: AN
authors.lastname: McCammond
authors.forename: Kevin
authors.initials: K
authors.lastname: Kuo
authors.forename: Victoria N
authors.initials: VN
authors.lastname: Parikh
authors.forename: Kameelah
authors.initials: K
authors.lastname: Abdullah
authors.forename: Raymond
authors.initials: R
authors.lastname: Balise
authors.forename: Frank L
authors.initials: FL
authors.lastname: Hanley
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Roth
mesh_terms: D002315:Cardiopulmonary Bypass / Q000009:adverse effects; D015505:Chest Tubes; D016009:Chi-Square Distribution; D002675:Child, Preschool; D004452:Echocardiography; D005260:Female; D018729:Fontan Procedure / Q000379:methods*; D006330:Heart Defects, Congenital / Q000601:surgery*; D006439:Hemodynamics; D006801:Humans; D007902:Length of Stay / Q000706:statistics & numerical data; D008297:Male; D011183:Postoperative Complications / Q000209:etiology / Q000517:prevention & control; D012086:Reoperation; D016896:Treatment Outcome