title: Cytomorphologic diagnosis and HPV testing of metastatic and primary oropharyngeal squamous cell carcinomas: a review and summary of the literature.
abstract: A significant proportion of squamous cell carcinomas (SCC) of the oropharynx are associated with high-risk human papillomavirus (HPV). These HPV-related carcinomas are prognostically and therapeutically different from traditional SCC of the head and neck. Cervical metastases from head and neck primary SCC are frequently investigated by fine-needle aspiration (FNA). HPV testing of cytologic samples from these lesions would potentially simplify diagnosis and therapeutic planning. This review summarizes current methodologies for HPV testing of FNA specimens and the role of HPV typing in diagnosis, prediction of prognosis, and selection of therapy.
authors.affiliation: Department of Pathology, University of Utah School of Medicine, Salt Lake City, Utah, USA.
authors.forename: Elke A
authors.initials: EA
authors.lastname: Jarboe
authors.forename: Jason P
authors.initials: JP
authors.lastname: Hunt
authors.forename: Lester J
authors.initials: LJ
authors.lastname: Layfield
mesh_terms: D052685:Alphapapillomavirus / Q000235:genetics / Q000302:isolation & purification* / Q000472:pathogenicity; D044963:Biopsy, Fine-Needle; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology / Q000821:virology*; D019941:Cyclin-Dependent Kinase Inhibitor p16; D003581:Cytodiagnosis / Q000379:methods*; D004279:DNA, Viral / Q000737:chemistry / Q000235:genetics; D055088:Early Detection of Cancer / Q000379:methods; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D009362:Neoplasm Metastasis / Q000175:diagnosis / Q000235:genetics / Q000473:pathology*; D009363:Neoplasm Proteins / Q000737:chemistry; D009959:Oropharyngeal Neoplasms / Q000473:pathology / Q000821:virology; D030361:Papillomavirus Infections / Q000175:diagnosis* / Q000821:virology; D011379:Prognosis
chemical_list: C000614131:CDKN2A protein, human; D019941:Cyclin-Dependent Kinase Inhibitor p16; D004279:DNA, Viral; D009363:Neoplasm Proteins