title: Luminescent lanthanide complexes with analyte-triggered antenna formation.
abstract: A new strategy for accessing analyte-responsive luminescent probes is presented. The lanthanide luminescence of Eu and Tb centers is switched on by the analyte-triggered formation of a sensitizing antenna from a nonsensitizing caged precursor. As the cage can be freely varied, an array of probes for different analytes (Pd(0/2+), H(2)O(2), F(-), β-galactosidase) can be created from the same core structure. The probe design affords nanomolar to micromolar detection limits, provides the capability to detect two analytes in parallel, and can be utilized to monitor enzymatic activity in live cells.
authors.affiliation: Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, 106 91 Stockholm, Sweden.
authors.forename: Elias
authors.initials: E
authors.lastname: Pershagen
authors.forename: Johan
authors.initials: J
authors.lastname: Nordholm
authors.forename: K Eszter
authors.initials: KE
authors.lastname: Borbas
mesh_terms: D004926:Escherichia coli / Q000201:enzymology; D005063:Europium / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000032:analysis*; D057230:Limit of Detection; D049408:Luminescent Agents / Q000737:chemistry*; D008163:Luminescent Measurements / Q000379:methods; D010165:Palladium / Q000032:analysis; D013725:Terbium / Q000737:chemistry*; D001616:beta-Galactosidase / Q000032:analysis*
chemical_list: D049408:Luminescent Agents; D013725:Terbium; D005063:Europium; D010165:Palladium; D006861:Hydrogen Peroxide; D001616:beta-Galactosidase