title: Erythrocytic or serum hydrogen sulfide association with hypertension development in untreated essential hypertension.
abstract: BACKGROUND
  Endogenous hydrogen sulfide (H(2)S) plays an important role in hypertension. The aim of this study was to investigate the role of erythrocyte and serum H(2)S in patients with untreated essential hypertension.
  
  
  METHODS
  We recruited 62 patients (age 22 - 74 years) with untreated prehypertension or hypertension, and 64 normotensive subjects (age 18 - 64 years). We assessed the 3-mercaptopyruvate sulphurtransferase (MPST) protein expression in erythrocytes and measured the H(2)S production from erythrocytes and serum H(2)S levels, then analyzed the association of erythrocytic or serum H(2)S content and blood pressure or cardiovascular risk factors (e.g., age, body mass index (BMI) and dyslipidemia). A stepwise regression analysis was used to evaluate the possible relationship of erythrocytic H(2)S in hypertension.
  
  
  RESULTS
  In hypertensive patients, erythrocyte H(2)S production ((111.04 ± 29.20) nmol/min per 10(8) erythrocytes) was higher than that in controls ((78.85 ± 19.38) nmol/min per 10(8) erythrocytes), and serum H(2)S was also higher. The erythrocytic H(2)S production was associated with increased systolic blood pressure (sBP), diastolic blood pressure (dBP), age, BMI, level of C-reactive protein (CRP), as well as triglycerides (TG) and high density lipoprotein cholesterol (HDL-C). Serum H(2)S was not associated with age or CRP. Stepwise regression analysis showed that erythrocytic H(2)S production was correlated with sBP, TG, HDL-C, low density lipoprotein cholesterol (LDL-C) and blood urea nitrogen (BUN) and serum H(2)S was correlated with dBP and TG. Results of receiver-operating characteristic curve analysis suggested that erythrocytic H(2)S production was a more sensitive predictor of hypertension development than serum H(2)S.
  
  
  CONCLUSIONS
  Erythrocytic or serum H(2)S production is sensitive predictor of hypertension.
authors.affiliation: Department of Cardiac Center, Peking University People's Hospital, Beijing 100044, China.
authors.forename: Mei
authors.initials: M
authors.lastname: Zheng
authors.forename: Qiang
authors.initials: Q
authors.lastname: Zeng
authors.forename: Xiao-Qin
authors.initials: XQ
authors.lastname: Shi
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
authors.forename: Chao-Shu
authors.initials: CS
authors.lastname: Tang
authors.forename: Ning-Ling
authors.initials: NL
authors.lastname: Sun
authors.forename: Bin
authors.initials: B
authors.lastname: Geng
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D006862:Hydrogen Sulfide / Q000097:blood*; D006973:Hypertension / Q000097:blood* / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D006862:Hydrogen Sulfide