title: Application of the BRAFO tiered approach for benefit-risk assessment to case studies on heat processing contaminants.
abstract: The aim of the European Funded Project BRAFO (benefit-risk analysis of foods) project was to develop a framework that allows quantitative comparison of human health risks and benefits of foods based on a common scale of measurement. This publication describes the application of the BRAFO methodology to three different case studies: the formation of acrylamide in potato and cereal based products, the formation of benzo(a)pyrene through smoking and grilling of meat and fish and the heat-treatment of milk. Reference, alternative scenario and target population represented the basic structure to test the tiers of the framework. Various intervention methods intended to reduce acrylamide in potato and cereal products were evaluated against the historical production methods. In conclusion the benefits of the acrylamide-reducing measures were considered prevailing. For benzo(a)pyrene, three illustrated alternative scenarios were evaluated against the most common smoking practice. The alternative scenarios were assessed as delivering benefits, introducing only minimal potential risks. Similar considerations were made for heat treatment of milk where the comparison of the microbiological effects of heat treatment, physico-chemical changes of milk constituents with positive and negative health effects was assessed. In general, based on data available, benefits of the heat treatment were outweighing any risks.
authors.affiliation: Procter & Gamble Eurocor, Temselaan 100 Box 43, 1853 Strombeek-Bever, Belgium.
authors.forename: Katrin
authors.initials: K
authors.lastname: Schütte
authors.forename: Heiner
authors.initials: H
authors.lastname: Boeing
authors.forename: Andy
authors.initials: A
authors.lastname: Hart
authors.forename: Walther
authors.initials: W
authors.lastname: Heeschen
authors.forename: Ernst H
authors.initials: EH
authors.lastname: Reimerdes
authors.forename: Dace
authors.initials: D
authors.lastname: Santare
authors.forename: Kerstin
authors.initials: K
authors.lastname: Skog
authors.forename: Alessandro
authors.initials: A
authors.lastname: Chiodini
mesh_terms: D020106:Acrylamide / Q000032:analysis; D000293:Adolescent; D000328:Adult; D000818:Animals; D001564:Benzo(a)pyrene / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D003296:Cooking / Q000379:methods; D002523:Edible Grain / Q000737:chemistry; D005060:Europe; D005399:Fishes; D005506:Food Contamination / Q000032:analysis* / Q000517:prevention & control; D005511:Food Handling / Q000379:methods*; D006358:Hot Temperature; D006801:Humans; D007223:Infant; D008460:Meat / Q000032:analysis; D008892:Milk / Q000737:chemistry / Q000382:microbiology; D018570:Risk Assessment / Q000379:methods*; D011198:Solanum tuberosum / Q000737:chemistry
chemical_list: D020106:Acrylamide; D001564:Benzo(a)pyrene