title: Duocarmycin analogues target aldehyde dehydrogenase 1 in lung cancer cells.
authors.affiliation: Department Chemie, Center for Integrated Protein Science, Institute of Advanced Studies, Technische Universität München, Lichtenbergstrasse 4, 85747 Garching, Germany.
authors.forename: Tanja
authors.initials: T
authors.lastname: Wirth
authors.forename: Kianga
authors.initials: K
authors.lastname: Schmuck
authors.forename: Lutz F
authors.initials: LF
authors.lastname: Tietze
authors.forename: Stephan A
authors.initials: SA
authors.lastname: Sieber
mesh_terms: D000080924:Aldehyde Dehydrogenase 1 Family; D018906:Antineoplastic Agents, Alkylating / Q000737:chemistry / Q000627:therapeutic use / Q000633:toxicity; D001665:Binding Sites; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D000080890:Duocarmycins; D006801:Humans; D007211:Indoles / Q000737:chemistry / Q000627:therapeutic use / Q000633:toxicity; D007527:Isoenzymes / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D008175:Lung Neoplasms / Q000188:drug therapy; D011758:Pyrroles / Q000737:chemistry / Q000627:therapeutic use / Q000633:toxicity; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D050697:Retinal Dehydrogenase / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D053719:Tandem Mass Spectrometry
chemical_list: D018906:Antineoplastic Agents, Alkylating; D000080890:Duocarmycins; D007211:Indoles; D007527:Isoenzymes; D011758:Pyrroles; D011994:Recombinant Proteins; C066098:duocarmycin SA; D000080924:Aldehyde Dehydrogenase 1 Family; C510223:ALDH1A1 protein, human; D050697:Retinal Dehydrogenase