title: [Successful treatment of congenital cytomegalovirus infection with valganciclovir].
abstract: Congenital cytomegalovirus (CMV) infection occurs frequently in neonates. However, there are no screening tests or definitive treatments for this infection in Japan. We report a case of a 21-day-old Japanese boy with congenital CMV infection. He was referred to our hospital for treatment of congenital bilateral deafness. Brain magnetic resonance imaging (MRI) revealed cortical dysplasia of the temporal poles, enlarged ventricles, and areas of abnormal intensity in the white matter. He was given a diagnosis of congenital CMV infection based on the detection of CMV DNA in his urine and the umbilical cord. After the administration of valganciclovir, no CMV DNA was detected in his serum, and brain MRI and electroencephalogram findings, motor development, and deafness improved. Further investigation is needed to establish a screening test and treatment for congenital CMV infection in Japan.
authors.affiliation: Department of Pediatrics, Tokyo Medical University, Tokyo. ishiyu@tokyo-med.ac.jp
authors.forename: Yu
authors.initials: Y
authors.lastname: Ishida
authors.forename: Tasuku
authors.initials: T
authors.lastname: Miyajima
authors.forename: Masaru
authors.initials: M
authors.lastname: Shimura
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Morichi
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Morishima
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Ioi
authors.forename: Shingo
authors.initials: S
authors.lastname: Oana
authors.forename: Gaku
authors.initials: G
authors.lastname: Yamanaka
authors.forename: Hisashi
authors.initials: H
authors.lastname: Kawashima
authors.forename: Akinori
authors.initials: A
authors.lastname: Hoshika
mesh_terms: D000914:Antibodies, Viral / Q000097:blood; D000998:Antiviral Agents / Q000008:administration & dosage*; D015415:Biomarkers / Q000097:blood / Q000652:urine; D003587:Cytomegalovirus / Q000235:genetics / Q000276:immunology; D003586:Cytomegalovirus Infections / Q000151:congenital* / Q000175:diagnosis / Q000188:drug therapy*; D004279:DNA, Viral / Q000652:urine; D004569:Electroencephalography; D015774:Ganciclovir / Q000008:administration & dosage / Q000031:analogs & derivatives*; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008297:Male; D016896:Treatment Outcome; D000077562:Valganciclovir
chemical_list: D000914:Antibodies, Viral; D000998:Antiviral Agents; D015415:Biomarkers; D004279:DNA, Viral; D007075:Immunoglobulin M; D000077562:Valganciclovir; D015774:Ganciclovir