title: [Development of current smallpox vaccines].
abstract: The review gives data on the history of smallpox vaccination and shows the high topicality of designing the current safe vaccines against orthopoxviruses. Four generations of live smallpox, protein subunit, and DNA vaccines are considered. Analysis of the data published leads to the conclusion that it is promising to use the up-to-date generations of safe smallpox subunit or DNA vaccines for mass primary immunization with possible further revaccination with classical live vaccine.
authors.forename: R A
authors.initials: RA
authors.lastname: Maksiutov
authors.forename: E V
authors.initials: EV
authors.lastname: Gavrilova
authors.forename: S N
authors.initials: SN
authors.lastname: Shchelkunov
mesh_terms: D000818:Animals; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans; D007117:Immunization, Secondary; D032541:Mass Vaccination / Q000379:methods / Q000639:trends; D018155:Orthopoxvirus / Q000276:immunology*; D012899:Smallpox / Q000276:immunology / Q000517:prevention & control; D012900:Smallpox Vaccine / Q000008:administration & dosage / Q000009:adverse effects / Q000266:history; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000009:adverse effects; D019444:Vaccines, DNA / Q000494:pharmacology / Q000821:virology*; D022223:Vaccines, Subunit / Q000494:pharmacology
chemical_list: D012900:Smallpox Vaccine; D014613:Vaccines, Attenuated; D019444:Vaccines, DNA; D022223:Vaccines, Subunit