title: Changes in prevalence of Helicobacter pylori infection after subtotal gastrectomy.
abstract: OBJECTIVE
  There have been few reports comparing pre and postoperative prevalence of Helicobacter pylori infection and gastritis in patients with gastric cancer surgery.
  
  
  METHODS
  Seventy patients with primary gastric cancer were identified to be infected with Helicobacter pylori preoperatively and tested for Helicobacter pylori infection after subtotal gastrectomy. We analyzed changes in Helicobacter pylori infectivity and histological features of gastric mucosa.
  
  
  RESULTS
  The overall spontaneous regression rate of Helicobacter pylori infection was 38.6% (27/70). The mean time between surgery and follow-up tests was 1.02±0.5 years. The activity and chronic inflammation scores were significantly decreased in regression group. In non-regression group, there was no significant difference in activity scores, but the chronic inflammation score was significantly increased. There were no significant changes in atrophic gastritis and intestinal metaplasia scores in either group. The grade of Helicobacter pylori infection was significantly decreased in non-regression group.
  
  
  CONCLUSIONS
  The spontaneous regression rate of Helicobacter pylori infection after subtotal gastrectomy was 38.6% (27/70), it occurred in larger scale of patients and it occurred earlier (1.02±0.5 years) than in previous studies. We suggest that further prospective study on spontaneous regression rate of Helicobacter pylori infection after subtotal gastrectomy and its mechanism is needed in the future.
authors.affiliation: Department of Internal Medicine, Seoul National University, Gyeonggi-do, Korea.
authors.forename: Seungchul
authors.initials: S
authors.lastname: Suh
authors.forename: Jong Chun
authors.initials: JC
authors.lastname: Nah
authors.forename: Min Sik
authors.initials: MS
authors.lastname: Uhm
authors.forename: Youn Mu
authors.initials: YM
authors.lastname: Jung
authors.forename: Nayoung
authors.initials: N
authors.lastname: Kim
authors.forename: Dong Ho
authors.initials: DH
authors.lastname: Lee
authors.forename: Hyun Chae
authors.initials: HC
authors.lastname: Jung
authors.forename: In Sung
authors.initials: IS
authors.lastname: Song
mesh_terms: D000328:Adult; D000368:Aged; D016009:Chi-Square Distribution; D005260:Female; D005743:Gastrectomy / Q000379:methods*; D005753:Gastric Mucosa / Q000382:microbiology / Q000473:pathology / Q000601:surgery*; D005757:Gastritis, Atrophic / Q000175:diagnosis / Q000453:epidemiology* / Q000382:microbiology; D016481:Helicobacter Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000382:microbiology; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008679:Metaplasia; D008875:Middle Aged; D015995:Prevalence; D012075:Remission, Spontaneous; D056910:Republic of Korea / Q000453:epidemiology; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000473:pathology / Q000601:surgery*; D013997:Time Factors; D016896:Treatment Outcome