title: Acute promyelocytic leukemia with unusual karyotype.
abstract: Acute myeloid leukemia (AML-M3) is associated with the translocation t(15;17)(q22;q12-21) which disrupts the retinoic acid receptor alpha (RARA) gene on chromosome 17 and the PML gene on chromosome 15. We report a two-year-old patient with AML-M3 without the usual translocation t(15;17). Cytogenetic studies demonstrated normal appearance of chromosome 15 while the abnormal 17 homologue was apparently a derivative 17, der(17)(17qter-cen-q21:), the rearrangement distinctly shows deletion at 17q21 band and the morphology corresponding to an iso chromosome i(17q-). This case report is a rare cytogenetic presentation of acute promyelocytic leukemia (APML).
authors.affiliation: Cytogenetics Unit, Department of Pathology, Kidwai Memorial Institute of Oncology, Bangalore - 560029, India.
authors.forename: Mangala
authors.initials: M
authors.lastname: Gowri
authors.forename: S K Kousar
authors.initials: SK
authors.lastname: Jahan
authors.lastname: Kavitha
authors.lastname: Prasannakumari
authors.lastname: Madhumathi
authors.forename: L
authors.initials: L
authors.lastname: Appaji