title: Prevalence and risk factors for chronic kidney disease in patients with coronary artery disease.
abstract: OBJECTIVE
  Chronic renal disease (CKD) is recognized as a worldwide public health problem. Traditional risk factors for CKD are also present in coronary artery disease (CAD). The purpose of this study is to examine the prevalence and characteristics of risk factors for CKD in the population with CAD.
  
  
  METHODS
  Renal function was evaluated in 527 patients with CAD in order to assess characteristics of the incidence, risk factors for CKD in the population with CAD. In the present study in order to concentrate on evaluation for eGFR of the patients with CAD proteinuria is not included in the definition of CKD.
  
  
  RESULTS
  Univariate analysis demonstrated that the major risk factors associated with CKD in the patients with CAD were age (P ≤ 0.001), smoking (P = 0.016), diabetes mellitus (P = 0.021), hypertension (P ≤ 0.001), and systolic blood pressure (P = 0.004). The percentages of patients with both hypertension and diabetes mellitus were significantly greater in the CKD3-4 group (P < 0.001). The results of multivariable analysis showed that hypertension (OR 1.925, 95% CI 1.196-3.098, P = 0.007), diabetes mellitus (OR 1.744, 95% CI 1.044-2.914, P = 0.034) and serum uric acid (OR 1.008, 95% CI 1.006-1.010, P ≤ 0.001) were independent risk factors for reduced eGFR.
  
  
  CONCLUSIONS
  CKD is common and has a high prevalence in the population with CAD. Several risk factors are known to simultaneously affect heart and kidney. The patients with CAD may be considered as a high-risk population for CKD.
authors.affiliation: Department of Nephrology, The First Affiliated Hospital of Harbin Medical University, Harbin Medical University, Harbin, China.
authors.forename: Yu-Shi
authors.initials: YS
authors.lastname: Bao
authors.forename: Shi-Ping
authors.initials: SP
authors.lastname: Na
authors.forename: Xi-Bei
authors.initials: XB
authors.lastname: Jia
authors.forename: Rui-Chan
authors.initials: RC
authors.lastname: Liu
authors.forename: Ming-Ao
authors.initials: MA
authors.lastname: Wang
authors.forename: Cheng-Yuan
authors.initials: CY
authors.lastname: Yu
authors.forename: Su-Hong
authors.initials: SH
authors.lastname: Mu
authors.forename: Ru-Juan
authors.initials: RJ
authors.lastname: Xie
mesh_terms: D000367:Age Factors; D000368:Aged; D003324:Coronary Artery Disease / Q000150:complications* / Q000453:epidemiology*; D003404:Creatinine / Q000097:blood; D003920:Diabetes Mellitus / Q000453:epidemiology / Q000209:etiology; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000209:etiology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011507:Proteinuria / Q000453:epidemiology / Q000209:etiology; D051436:Renal Insufficiency, Chronic / Q000453:epidemiology* / Q000209:etiology*; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects
chemical_list: D003404:Creatinine