title: [Poisonings in pregnancy].
abstract: Attempted suicides and poisonings in pregnancy are a challenge for health care professionals because of the unknown effects of the toxic agent and the antidote therapy on the unborn. In case of intoxication, the malformation risk is often overestimated. In contrast, pertinent data show that the risk is not very high as long as the drug is not known as a teratogen and the mother's health is not substantially impaired. This applies to suicide attempts with acetaminophen, iron-containing products, and multidrug overdoses with psychopharmaceuticals as well as snake and spider bites and the ingestion of poisonous mushrooms. It is of utmost importance that the pregnant patient receives the same detoxification and supportive therapy following pertinent guidelines as a non-pregnant patient. The fetus should be followed-up by ultrasound with special focus on its vital parameters, movement pattern, and normal growth and organ differentiation. As long as the maternal health status is not substantially impaired, there is no indication to discuss elective termination of pregnancy "for toxicological reasons".
authors.affiliation: Pharmakovigilanz- und Beratungszentrum für Embryonaltoxikologie, Institut für Klinische Pharmakologie und Toxikologie, Charité-Universitätsmedizin Berlin, Campus Virchow-Klinikum, Berlin, Deutschland. christof.schaefer@charite.de
authors.forename: C
authors.initials: C
authors.lastname: Schaefer
authors.forename: P
authors.initials: P
authors.lastname: Hoffmann-Walbeck
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control; D000931:Antidotes / Q000009:adverse effects / Q000627:therapeutic use; D003299:Cooperative Behavior; D004632:Emergency Medical Services; D005260:Female; D005323:Fetal Monitoring; D019983:Guideline Adherence; D006801:Humans; D007231:Infant, Newborn; D033183:Interdisciplinary Communication; D009145:Mushroom Poisoning / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D011041:Poisoning / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D063487:Prescription Drug Misuse; D012909:Snake Bites / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D013406:Suicide, Attempted; D013723:Teratogens
chemical_list: D000931:Antidotes; D013723:Teratogens