title: Histomorphological researches on large porous hydroxyapatite cylinder tubes with polylactic acid surface coating in different nonskeletal sites in vivo.
abstract: Porous hydroxyapatite (HA) ceramic cylinder tubes coated with polylactic acid on the exposed surfaces were implanted in four nonskeletal sites (omentum, peritoneum, vastus lateralis, and side of femur). Six months postoperatively, proper amount of Chinese ink was injected to dye the implanting areas. Decalcified and nondecalcified sections were observed under inverted microscope. The results showed that the soft tissues around the HA cylinder tubes in peritoneum, vastus lateralis, and side of femur groups appeared visible black. Some small blacked vascular architectures were also discernible. However in omentum group, only small number of blacked vessels existed. Histological observations indicated that vascularization and ossification occurred in peritoneum, vastus lateralis, and side of femur groups. In omentum group, there was no any sign of vascularization and ossification. A conclusion could be made in this study that excepting bones and muscles, parietal peritoneum could serve as a potential spot for culturing histoengineering hydroxyapatite (HA)-polylactic acid (PLA) ceramic bone substitutes.
authors.affiliation: Department of Orthopedics, 452nd Hospital of Chinese PLA, Chengdu, Sichuan, People's Republic of China. cong60@hotmail.com
authors.forename: Cong
authors.initials: C
authors.lastname: Zhang
authors.forename: Peng
authors.initials: P
authors.lastname: Huang
authors.forename: Jie
authors.initials: J
authors.lastname: Weng
authors.forename: Wei
authors.initials: W
authors.lastname: Zhi
authors.forename: Yonghe
authors.initials: Y
authors.lastname: Hu
authors.forename: Huaizhi
authors.initials: H
authors.lastname: Feng
authors.forename: Yimin
authors.initials: Y
authors.lastname: Yao
authors.forename: Shuo
authors.initials: S
authors.lastname: Li
authors.forename: Tian
authors.initials: T
authors.lastname: Xia
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000187:drug effects / Q000473:pathology; D020099:Coated Materials, Biocompatible / Q000494:pharmacology*; D004285:Dogs; D017886:Durapatite / Q000494:pharmacology*; D019344:Lactic Acid / Q000494:pharmacology*; D008297:Male; D018919:Neovascularization, Physiologic / Q000187:drug effects; D009928:Organ Specificity / Q000187:drug effects*; D010012:Osteogenesis / Q000187:drug effects; D011091:Polyesters; D011108:Polymers / Q000494:pharmacology*; D016062:Porosity / Q000187:drug effects; D013499:Surface Properties / Q000187:drug effects; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D020099:Coated Materials, Biocompatible; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide); D017886:Durapatite