title: [Efficacy and tolerance of rezonizate in complex with fluoroquinolones or mycobutin on a model of experimental murine tuberculosis].
abstract: The efficacy of rezonizate, a novel antituberculosis drug, in combination with fluoroquinolones or mycobutin was studied in experiments on mice infected with Mycobacterium tuberculosis. By the pathomorphological and microbiological criteria, the highest therapeutic effect was observed when rezonizate was used in combination with levofloxacin, the lowest effect was produced by rezonizate combination with gatifloxacin.
authors.forename: G B
authors.initials: GB
authors.lastname: Sokolova
authors.forename: B M
authors.initials: BM
authors.lastname: Maliev
authors.forename: G N
authors.initials: GN
authors.lastname: Mozhokina
authors.forename: N A
authors.initials: NA
authors.lastname: Elistratova
authors.forename: I P
authors.initials: IP
authors.lastname: Solov'eva
authors.forename: S E
authors.initials: SE
authors.lastname: Bugaenko
mesh_terms: D000818:Animals; D000904:Antibiotics, Antitubercular / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D004361:Drug Tolerance; D024841:Fluoroquinolones / Q000008:administration & dosage*; D000077734:Gatifloxacin; D007555:Isoxazoles / Q000008:administration & dosage*; D064704:Levofloxacin; D051379:Mice; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D015242:Ofloxacin / Q000008:administration & dosage*; D023303:Oxazolidinones / Q000008:administration & dosage*; D017828:Rifabutin / Q000008:administration & dosage*; D014376:Tuberculosis / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000904:Antibiotics, Antitubercular; D024841:Fluoroquinolones; D007555:Isoxazoles; D023303:Oxazolidinones; C100142:terizidone; D017828:Rifabutin; D064704:Levofloxacin; D015242:Ofloxacin; D000077734:Gatifloxacin