title: Spectral domain OCT versus time domain OCT in the evaluation of macular features related to wet age-related macular degeneration.
abstract: BACKGROUND
  The aim of this study was to compare the agreement between spectral domain optical coherence tomography (SD OCT) and time domain stratus OCT (TD OCT) in evaluating macular morphology alterations in wet age-related macular degeneration (AMD).
  
  
  METHODS
  This retrospective study was performed on 77 eyes of 77 patients with primary or recurring subfoveal choroidal neovascularization secondary to AMD. All patients underwent OCT examination using Zeiss Stratus OCT 3 (Carl Zeiss Meditec Inc, Dublin, CA) and Opko OTI Spectral SLO/OCT (Ophthalmic Technologies Inc, Toronto, Canada). In all radial line scans, the presence of intraretinal edema (IRE), serous pigment epithelium detachment (sPED), neurosensory serous retinal detachment (NSRD), epiretinal membrane (EM), inner limiting membrane thickening (ILMT), and hard exudates (HE) were evaluated. The degree of matching was quantified by Kappa measure of agreement.
  
  
  RESULTS
  THE PERCENTAGE DISTRIBUTION OF TD OCT FINDINGS VERSUS SD OCT FINDINGS WAS: IRE 36.3% versus 77.9%, sPED 57.1% versus 85.7%, NSRD 38.9% versus 53.2%, EM 10.5% versus 26.3%, ILMT 3.8% versus 32.4%, and HE 6.4% versus 54.5%. The agreement was as follows: sPED: kappa value 0.15; NSRD: kappa value 0.61; IRE: kappa value 0.18; EM: kappa value 0.41; ILMT: kappa value 0.02; HE: kappa value 0.06.
  
  
  CONCLUSIONS
  The agreement in the evaluation of macular lesions between the two techniques is poor and depends on the lesion considered. SD OCT allows better detection of the alterations typically related to choroidal neovascularization such as IRE, PED, ILM thickening, and HE. Consequently its use should be strongly considered in patients with wet AMD.
authors.affiliation: Department of Ophthalmology, University Vita-Salute, Scientific Institute San Raffaele, Milano, Italy.
authors.forename: Luisa
authors.initials: L
authors.lastname: Pierro
authors.forename: Elena
authors.initials: E
authors.lastname: Zampedri
authors.forename: Paolo
authors.initials: P
authors.lastname: Milani
authors.forename: Marco
authors.initials: M
authors.lastname: Gagliardi
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Isola
authors.forename: Alfredo
authors.initials: A
authors.lastname: Pece