title: TEMPO-mediated electrooxidation of primary and secondary alcohols in a microfluidic electrolytic cell.
abstract: A general procedure for the 2,2,6,6-tetramethylpiperidine-1-oxyl (TEMPO)-mediated electrooxidation of primary and secondary alcohols modified for application in a microfluidic electrolytic cell is described. The electrocatalytic system utilises a buffered aqueous tert-butanol reaction medium, which operates effectively without the requirement for additional electrolyte, providing a mild protocol for the oxidation of alcohols to aldehydes and ketones at ambient temperature on a laboratory scale. Optimisation of the process is discussed along with the oxidation of 15 representative alcohols.
authors.affiliation: School of Chemistry, University of Southampton, Southampton, Hampshire, UK.
authors.forename: Joseph T
authors.initials: JT
authors.lastname: Hill-Cousins
authors.forename: Jekaterina
authors.initials: J
authors.lastname: Kuleshova
authors.forename: Robert A
authors.initials: RA
authors.lastname: Green
authors.forename: Peter R
authors.initials: PR
authors.lastname: Birkin
authors.forename: Derek
authors.initials: D
authors.lastname: Pletcher
authors.forename: Toby J
authors.initials: TJ
authors.lastname: Underwood
authors.forename: Stuart G
authors.initials: SG
authors.lastname: Leach
authors.forename: Richard C D
authors.initials: RC
authors.lastname: Brown
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D003497:Cyclic N-Oxides / Q000737:chemistry*; D004563:Electrochemistry; D004572:Electrolysis / Q000295:instrumentation*; D055772:Green Chemistry Technology / Q000295:instrumentation*; D006863:Hydrogen-Ion Concentration; D046210:Microfluidic Analytical Techniques / Q000379:methods*; D010084:Oxidation-Reduction; D013696:Temperature
chemical_list: D000438:Alcohols; D003497:Cyclic N-Oxides; C003959:TEMPO