title: Value of albumin-globulin ratio as a predictor of all-cause mortality after non-ST elevation myocardial infarction.
abstract: Low albumin and the albumin-globulin ratio (AGR) were associated with vascular adverse events. Our study explores the AGR as a predictor of mortality after non-ST-segment elevation myocardial infarction (NSTEMI). In an observational study of 570 NSTEMI patients admitted to a tertiary center between 2004 and 2006, patients were stratified into equal tertiles according to AGR. The primary outcome was 4-year all-cause mortality. The 4-year mortality rates in the first, second, and third AGR tertiles were 88 (47%) of 189, 48 (25%)of 190 , and 19 (10%) of 191, respectively (P < .0001). After adjusting for 20 confounding variables, AGR first tertile (AGR <1.12) had a higher mortality versus second tertile (hazard ratio [HR] 2.6, P < .001). Likewise, the AGR second tertile had higher mortality versus the third tertile (AGR ≥1.34; HR 2.3, P = .004). The albumin-globulin ratio is a significant independent predictor of long-term mortality after NSTEMI in patients with normal serum albumin levels. Further studies are needed to explain the underlying mechanisms.
authors.affiliation: Department of Internal Medicine, Staten Island University Hospital, Staten Island, NY 10305, USA. basemnady2000@yahoo.com
authors.forename: Basem
authors.initials: B
authors.lastname: Azab
authors.forename: John
authors.initials: J
authors.lastname: Bibawy
authors.forename: Kassem
authors.initials: K
authors.lastname: Harris
authors.forename: Georges
authors.initials: G
authors.lastname: Khoueiry
authors.forename: Meredith
authors.initials: M
authors.lastname: Akerman
authors.forename: Jason
authors.initials: J
authors.lastname: Selim
authors.forename: Silivia
authors.initials: S
authors.lastname: Khalil
authors.forename: Scott
authors.initials: S
authors.lastname: Bloom
authors.forename: Joseph T
authors.initials: JT
authors.lastname: McGinn
mesh_terms: D000368:Aged; D000418:Albumins / Q000032:analysis*; D002423:Cause of Death; D005260:Female; D005916:Globulins / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000401:mortality*; D011237:Predictive Value of Tests
chemical_list: D000418:Albumins; D005916:Globulins