title: Clinical response to chemotherapy in locally advanced breast cancer was not associated with several polymorphisms in detoxification enzymes and DNA repair genes.
abstract: The main aim of the present study was to investigate the association between several genetic polymorphisms (in glutathione S-transferase members and DNA repair genes) and clinical response to chemotherapy in locally advanced breast cancer. A sequential series of 101 patients were prospectively included in this study. Clinical assessment of treatment was accomplished by comparing initial tumor size with preoperative tumor size using revised RECIST guideline (version 1.1). Clinical response was regarded as a response or no response. There was no difference between non-responders and responders for the prevalence of genotypes of the study polymorphisms.
authors.affiliation: Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran. msaadat41@yahoo.com
authors.forename: Mostafa
authors.initials: M
authors.lastname: Saadat
authors.forename: Maryam
authors.initials: M
authors.lastname: Khalili
authors.forename: Meysam
authors.initials: M
authors.lastname: Nasiri
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Rajaei
authors.forename: Shahpour
authors.initials: S
authors.lastname: Omidvari
authors.forename: Iraj
authors.initials: I
authors.lastname: Saadat
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D034961:Antigens, Nuclear / Q000235:genetics*; D024221:Antineoplastic Protocols; D001943:Breast Neoplasms / Q000188:drug therapy*; D004260:DNA Repair / Q000235:genetics*; D051747:DNA-Activated Protein Kinase / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D004351:Drug Resistance / Q000235:genetics*; D005260:Female; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008658:Inactivation, Metabolic / Q000235:genetics*; D000072200:Ku Autoantigen; D008875:Middle Aged; D009687:Nuclear Proteins / Q000235:genetics*; D011110:Polymorphism, Genetic; D011446:Prospective Studies; D016896:Treatment Outcome; D000076105:X-ray Repair Cross Complementing Protein 1
chemical_list: D034961:Antigens, Nuclear; D051747:DNA-Activated Protein Kinase; D004268:DNA-Binding Proteins; D005982:Glutathione Transferase; D000072200:Ku Autoantigen; D009687:Nuclear Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C407705:GSTZ1 protein, human; C413545:glutathione S-transferase T1; C490476:GSTO1 protein, human; C497263:PRKDC protein, human; C000606509:Xrcc6 protein, human