title: [Diagnosis and treatment of 11 cases with sinonasal neuroendocrine carcinoma].
abstract: OBJECTIVE
  To explore the diagnosis and treatment and prognosis of sinonasal neuroendocrine carcinoma.
  
  
  METHODS
  The clinical data of 11 cases with sinonasal neuroendocrine carcinoma treated in Zhejiang Cancer Hospital from 1998 to 2010 were analyzed retrospectively. Ten cases were small cell type and one case was atypical carcinoid. One case by only operation, one case by only radiotherapy, one case by only chemotherapy, two cases by radiotherapy and chemotherapy, 6 cases by combined treatment based on surgery (surgery combined with radiotherapy and chemotherapy).
  
  
  RESULTS
  All cases have been followed up for 2 months to 12 years. Six cases by combined treatment one case died in 3 years and one case died in 4 years after treatment, one case has survived without tumor for 12 years and two cases have survived without tumor for 8 years, one case was still in treatment. Five cases of other treatment programs, four cases died in 12 months, one case died in 18 months.
  
  
  CONCLUSIONS
  There's no standard treatment plan. Combined treatment based on surgery should be adopted to nasal neuroendocrine carcinoma. Reccurrence is frequent and the prognosis is poor. The key to improving the survival rate of the disease is early accurate diagnosis and combined treatment.
authors.affiliation: Department of Otolaryngology, Huzhou Central Hospital, Huzhou, China.
authors.forename: Guo-hong
authors.initials: GH
authors.lastname: Qian
authors.forename: Jin-biao
authors.initials: JB
authors.lastname: Shang
authors.forename: Ke-jing
authors.initials: KJ
authors.lastname: Wang
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Tan
mesh_terms: D000328:Adult; D000368:Aged; D018278:Carcinoma, Neuroendocrine / Q000175:diagnosis / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009669:Nose Neoplasms / Q000175:diagnosis / Q000628:therapy; D010255:Paranasal Sinus Neoplasms / Q000175:diagnosis / Q000628:therapy; D011379:Prognosis; D012189:Retrospective Studies