title: [A case of IgG4-related disease with marked thickening of the bronchial wall].
abstract: A 52-year-old man noticed hardening and swelling of his salivary glands in the summer of 2009. We suspected Mikulicz disease and performed several work-ups. His serum IgG4 level was elevated, and a chest computed tomography scan demonstrated marked thickening of the bronchial wall. A histopathologic examination of a bronchial mucosa biopsy specimen revealed diffuse infiltration of IgG4-positive cells in the submucosal layers, and on this basis we diagnosed IgG4-related disease. After the administration of corticosteroids, the patient's symptoms, his serum IgG4 level and bronchial wall thickening all improved. When encountering a patient with thickening of the bronchial wall, IgG4-related disease should be considered.
authors.affiliation: Department of Internal Medicine, Joetsu General Hospital.
authors.forename: Masachika
authors.initials: M
authors.lastname: Hayashi
authors.forename: Masaaki
authors.initials: M
authors.lastname: Okajima
authors.forename: Takashi
authors.initials: T
authors.lastname: Shimizu
authors.forename: Natsue
authors.initials: N
authors.lastname: Shimizu
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Morohashi
authors.forename: Jozi
authors.initials: J
authors.lastname: Toyama
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Mori
mesh_terms: D001980:Bronchi / Q000473:pathology*; D006801:Humans; D006942:Hypergammaglobulinemia / Q000188:drug therapy / Q000473:pathology*; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use
chemical_list: D007074:Immunoglobulin G; D011239:Prednisolone