title: Identification of pharmacophore in bioactive metal complexes: Synthesis, spectroscopic characterization and application.
abstract: Bacteria are amongst the most adaptable organisms on the Earth. The year 2010 was always remarkable for the article published in Lancet Infection Disease by Kumarasamy et al. and the enzyme NDM-1 which makes bacteria resist designed to kill them. Four rhodium(III) chloride complexes with Gatifloxacin have been prepared and characterized by elemental analyses, molar conductance measurements, FTIR, FAB-MS, TGA, (1)H NMR and electronic spectral studies. The general formula for complexes are [X](+)fac-[RhCl(3)(L)(GT)](-); where L = H(2)O, Dimethylsulfoxide (DMSO), Tetramethylenesulfoxide (TMSO); GT = Gatifloxacin and X = Na or [H(DMSO)(2)]. All complexes are found to possess prominent antibacterial activity against pathogenic Escherichia coli and Mycobacterium tuberculosis in comparison to Gatifloxacin.
authors.affiliation: Coordination Chemistry Research Lab, Department of Chemistry, Govt. Science College, Jabalpur (MP) 482001, India. ripul.mehrotra@gmail.com
authors.forename: Ripul
authors.initials: R
authors.lastname: Mehrotra
authors.forename: Satyendra N
authors.initials: SN
authors.lastname: Shukla
authors.forename: Pratiksha
authors.initials: P
authors.lastname: Gaur
authors.forename: Archana
authors.initials: A
authors.lastname: Dubey
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000494:pharmacology; D002478:Cells, Cultured; D056831:Coordination Complexes / Q000737:chemistry*; D004926:Escherichia coli / Q000187:drug effects*; D024841:Fluoroquinolones / Q000494:pharmacology; D000077734:Gatifloxacin; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D013055:Spectrophotometry, Infrared; D013816:Thermodynamics
chemical_list: D000900:Anti-Bacterial Agents; D000995:Antitubercular Agents; D056831:Coordination Complexes; D024841:Fluoroquinolones; D000077734:Gatifloxacin