title: Role of IGF-1 receptor in radiation response.
abstract: Insulin-like growth factor 1 receptor (IGF-1R) is a transmembrane receptor tyrosine kinase involved in the development and progression of cancer whose activation strongly promotes cell growth and survival. IGF-1R exerts its main actions through the activation of the mitogen-activated protein kinase and phosphoinositide 3-kinase pathways. In addition to their traditional roles, IGF-1R activation has been associated with increased radioresistance both in vitro and in vivo, although the molecular mechanisms behind this process are still unclear. Recently, IGF-1R has been associated to new partners as major vault proteins, BCL-2, BAX, or Ku70/80, related to radiochemotherapy resistance, regulation of apoptosis, and nonhomologous end-joining DNA repair. Here, we review these novel associations of IGF-1R trying to explain the resistance to radiotherapy mediated by IGF-1R. Finally, we revised the role of new therapies leading to block the receptor to enhance the efficacy of radiation.
authors.affiliation: Instituto Canario de Investigación del Cáncer, Canary Islands, Spain.
authors.forename: Almudena
authors.initials: A
authors.lastname: Valenciano
authors.forename: Luis Alberto
authors.initials: LA
authors.lastname: Henríquez-Hernández
authors.forename: Mercedes
authors.initials: M
authors.lastname: Moreno
authors.forename: Marta
authors.initials: M
authors.lastname: Lloret
authors.forename: Pedro Carlos
authors.initials: PC
authors.lastname: Lara