title: Stereoselective intramolecular cyclization to 4-(hydroxymethyl)-3-(1H-indolyl)oxazolidin-2-ones.
abstract: A simple high-yield three-steps route to optically active 4-hydroxymethyl-3-(1H-indolyl)oxazolidin-2-ones from (S)-glycidol is described. The key intermediates (R)-oxiran-2-ylmethyl 1H-indol-4/-5-ylcarbamates are obtained in high yields from (S)-glycidol. These are readily transformed to oxazolidin-2-ones, very interesting building blocks in drug synthesis.
authors.affiliation: Dipartimento di Chimica A. M. Tamburro, Università degli Studi della Basilicata, Via dell'Ateneo Lucano 10, 85100, Potenza, Italy.
authors.forename: Lucia
authors.initials: L
authors.lastname: Chiummiento
authors.forename: Maria
authors.initials: M
authors.lastname: Funicello
authors.forename: Francesco
authors.initials: F
authors.lastname: Tramutola