title: The value of early second trimester PAPP-A and ADAM12 in screening for pre-eclampsia.
abstract: OBJECTIVE
  To estimate the pre-eclampsia screening performance of PAPP-A (pregnancy-associated plasma protein-A) and ADAM12 (A Disintegrin And Metalloprotease 12) in the early second trimester of pregnancy.
  
  
  METHODS
  Stored frozen serum samples from a previously published nested case-control study comprising 77 women who developed pre-eclampsia and 224 unaffected controls were thawed and assayed for PAPP-A and ADAM12. Levels were converted into multiple of the unaffected median (MoM) values.
  
  
  RESULTS
  Neither PAPP-A or ADAM12 were significantly different in women who developed pre-eclamspia compared with unaffected controls (PAPP-A: 0.97 MoM [95% confidence interval 0.73 to 1.25], ADAM12: 1.01 MoM [0.91 to 1.13]).
  
  
  CONCLUSIONS
  Our results do not support the use of PAPP-A or ADAM12 in early second trimester antenatal screening for pre-eclampsia.
authors.affiliation: Wolfson Institute of Preventive Medicine, Barts and London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ. j.p.bestwick@qmul.ac.uk
authors.forename: Jonathan P
authors.initials: JP
authors.lastname: Bestwick
authors.forename: Lynne M
authors.initials: LM
authors.lastname: George
authors.forename: Tiesheng
authors.initials: T
authors.lastname: Wu
authors.forename: Joan K
authors.initials: JK
authors.lastname: Morris
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Wald
mesh_terms: D051722:ADAM Proteins / Q000032:analysis / Q000097:blood*; D000072199:ADAM12 Protein; D000328:Adult; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D005865:Gestational Age; D006801:Humans; D008403:Mass Screening / Q000379:methods / Q000592:standards; D008565:Membrane Proteins / Q000032:analysis / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology / Q000208:ethnology; D011237:Predictive Value of Tests; D011247:Pregnancy; D011262:Pregnancy Trimester, Second / Q000097:blood* / Q000208:ethnology; D011266:Pregnancy-Associated Plasma Protein-A / Q000032:analysis*; D011296:Prenatal Diagnosis / Q000379:methods / Q000592:standards
chemical_list: D015415:Biomarkers; D008565:Membrane Proteins; D051722:ADAM Proteins; D000072199:ADAM12 Protein; C000606480:ADAM12 protein, human; D011266:Pregnancy-Associated Plasma Protein-A