title: A therapeutic method for the direct reprogramming of human liver cancer cells with only chemicals.
abstract: Various methods for the direct reprogramming of human somatic cells have been developed. However, a therapeutic method to reprogram and eliminate human solid tumor cells has not been developed. Here we show a novel therapeutic method to reprogram and eliminate human solid tumor cells with chemicals. This therapeutic method may be applicable to various human solid tumor cells that express aldo-keto reductase family 1 member B10 (AKR1B10) and retinoid X receptors (RXRs).
authors.forename: Hisashi
authors.initials: H
authors.lastname: Moriguchi
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhang
authors.forename: Makoto
authors.initials: M
authors.lastname: Mihara
authors.forename: Chifumi
authors.initials: C
authors.lastname: Sato
mesh_terms: D000449:Aldehyde Reductase / Q000378:metabolism; D000074408:Aldo-Keto Reductases; D006528:Carcinoma, Hepatocellular / Q000201:enzymology / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008113:Liver Neoplasms / Q000201:enzymology / Q000378:metabolism / Q000473:pathology*; D016031:Liver Transplantation; D010101:Oxygen Consumption; D047488:Retinoid X Receptors / Q000378:metabolism; D012176:Retinoids / Q000494:pharmacology*
chemical_list: D047488:Retinoid X Receptors; D012176:Retinoids; C120471:AKR1B10 protein, human; D000074408:Aldo-Keto Reductases; D000449:Aldehyde Reductase