title: In vitro promoting activity of human interferon β production by extracts of marine algae from Japan.
abstract: Two hundreds species of marine algae were investigated for in vitro promoting activity of human interferon β (IFN-β) production by poly(I:C)-induced human osteosarcoma cell line, MG-63. A brown alga, Sargassum hemipyllum promoted most its activity, showing more than 11-fold. When we attempted to partially purify the active substances by particular two-step chromatography, two peaks of active fractions were obtained. These fractioned materials exhibited the heat-stable and non-cytotoxic characters with the molecular weight less than 3000.
authors.forename: T
authors.initials: T
authors.lastname: Nakano
authors.forename: T
authors.initials: T
authors.lastname: Noro
authors.forename: Y
authors.initials: Y
authors.lastname: Kamei