title: Quantification of fexofenadine in biological matrices: a review of bioanalytical methods.
abstract: Fexofenadine (FEX) has been extensively used for therapeutic benefits after the market withdrawal of terfenadine. Recently, the popularity of FEX has emerged owing to its unique disposition via drug transporters and, hence, it has been used as a model probe for both in vitro and in vivo investigations to understand mechanistic aspects of drug-drug interactions (DDI). Going hand in hand with the increased use of FEX in therapy and research, numerous bioanalytical methods for FEX have been published. The various published bioanalytical methods for FEX are collated in this review to provide a comprehensive information on extraction methodology, assay conditions, chromatography and detection systems. Generally, the published methods have been adequately validated and can be readily used to support the use of FEX in pharmcokinetic, DDI and mechanistic investigations.
authors.affiliation: The Key Laboratory for Special Functional Materials, Henan University, Kaifeng, Henan, 475001, People's Republic of China.
authors.forename: Ming
authors.initials: M
authors.lastname: Yao
authors.forename: Nuggehally R
authors.initials: NR
authors.lastname: Srinivas
mesh_terms: D000818:Animals; D002853:Chromatography, Liquid / Q000379:methods*; D006801:Humans; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D053719:Tandem Mass Spectrometry / Q000379:methods*; D016593:Terfenadine / Q000031:analogs & derivatives* / Q000032:analysis / Q000737:chemistry / Q000493:pharmacokinetics
chemical_list: D016593:Terfenadine; C093230:fexofenadine