title: Association of adiponectin with blood pressure in healthy people.
abstract: OBJECTIVE
  With the increasing prevalence of diseases related to obesity, metabolic syndrome and its key player adiponectin are now attracting considerable attention. Hypoadiponectinaemia is reported to be a risk factor for hypertension and associated with endothelial dysfunction, which is closely related to complications of obesity such as hypertension. As there is limited information regarding serum adiponectin levels in normotensive people, we undertook the large-scale study to determine the association of adiponectin with blood pressure (BP) in mainly normotensive people.
  
  
  METHODS
  In 21 100 Japanese adults (12 363 men and 8737 women) who had no apparent diseases, we examined the relationship between the serum adiponectin concentration and BP by performing a questionnaire survey, physical measurements and measurement of laboratory parameters including the serum adiponectin level.
  
  
  RESULTS
  Subjects with hypoadiponectinaemia had higher systolic and diastolic BPs as already reported. And interestingly, subjects with higher adiponectin had lower systolic and diastolic BP. According to linear regression analysis, adiponectin showed a significant negative correlation with systolic and diastolic BP independently of the other variables. Analysis of covariance according to adiponectin quintiles showed that systolic and diastolic BP in highest adiponectin quintile was significantly lower than in other quintiles.
  
  
  CONCLUSIONS
  This study revealed that there were significant trends toward lower systolic and diastolic BP with higher adiponectin not only in hypertensive people but also in normotensive people.
authors.affiliation: Department of Endocrinology and Metabolism, Sumitomo Hospital, Osaka, Japan. megmegoo_y@yahoo.co.jp
authors.forename: Megu Y
authors.initials: MY
authors.lastname: Baden
authors.forename: Yuya
authors.initials: Y
authors.lastname: Yamada
authors.forename: Yasumitsu
authors.initials: Y
authors.lastname: Takahi
authors.forename: Yoshinari
authors.initials: Y
authors.lastname: Obata
authors.forename: Kenji
authors.initials: K
authors.lastname: Saisho
authors.forename: Sachiko
authors.initials: S
authors.lastname: Tamba
authors.forename: Koji
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Miyuki
authors.initials: M
authors.lastname: Umeda
authors.forename: Aiko
authors.initials: A
authors.lastname: Furubayashi
authors.forename: Yoshifumi
authors.initials: Y
authors.lastname: Tsukamoto
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Sakaguchi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Matsuzawa
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000375:Aging; D001794:Blood Pressure / Q000502:physiology*; D015992:Body Mass Index; D001835:Body Weight; D005260:Female; D006801:Humans; D007564:Japan; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011247:Pregnancy
chemical_list: D052242:Adiponectin