title: [Cytomegalovirus enteritis after allogeneic hematopoietic stem cell transplantation].
abstract: OBJECTIVE
  To analyse the clinical features, diagnostic methods and risk factors of cytomegalovirus (CMV) enteritis after allogeneic hematopoietic stem cell transplantation (allo-HSCT).
  
  
  METHODS
  Analysis was made on 24 cases of CMV enteritis after allo-HSCT in Beijing Daopei Hospital from Aug. 2007 to Jul. 2009, including clinical data, endoscopic diagnosis, histopathological and virological results, and the association between CMV enteritis with viremia and graft-versus-host disease(GVHD).
  
  
  RESULTS
  87.5% of the patients were over 18 years old. The median time to diagnosis of CMV enteritis was 63 days after HSCT. The mucosal lesions in enteroscopic examination had no significant differences between CMV enteritis and gastrointestinal GVHD complicated with the enteritis. The methods used in diagnosis included histopathology (32.1%) and virology (92.9%). The copies of CMVDNA in mucosal samples greater than 10(5)/10(6) PBNC was better diagnosis. A number of risk factors were compared between the survival and death groups: type of transplant, conditioning regimen, the time span of ganciclovir prophylaxis therapy, grade II-IV GVHD before enteritis, the time of diagnosis as GVHD, using MP > or = 1 mg/kg to treat GVHD, the time between GVHD and enteritis, CMV viremia before enteritis, the time of diagnosis as enteritis, CMVDNA quantitation, and there were no any statistic differences.
  
  
  CONCLUSIONS
  Cytomegalovirus enteritis should be carefully diagnosed by histopathology and virology through endoscopic examination. It is better to undertake pan-colon endoscopy as well as terminal ileum examination for more accurate diagnosis. PCR can significantly improve the detection rate. CMVDNA detection in patients' stool may be helpful to diagnosis, especially for those patients who can not stand the endoscopy examination.
authors.affiliation: Beijing Daopei Hospital, Beijing, China.
authors.forename: Yu-Ming
authors.initials: YM
authors.lastname: Yin
authors.forename: Tong
authors.initials: T
authors.lastname: Wu
authors.forename: Shu-Quan
authors.initials: SQ
authors.lastname: Ji
authors.forename: Wan-Ming
authors.initials: WM
authors.lastname: Da
authors.forename: Yan-Li
authors.initials: YL
authors.lastname: Zhao
authors.forename: Jing-Bo
authors.initials: JB
authors.lastname: Wang
authors.forename: Xing-Yu
authors.initials: XY
authors.lastname: Cao
authors.forename: Yue
authors.initials: Y
authors.lastname: Lu
authors.forename: Yuan
authors.initials: Y
authors.lastname: Sun
authors.forename: Chun-Rong
authors.initials: CR
authors.lastname: Tong
authors.forename: Dao-Pei
authors.initials: DP
authors.lastname: Lu
mesh_terms: D000293:Adolescent; D000328:Adult; D003587:Cytomegalovirus; D003586:Cytomegalovirus Infections / Q000209:etiology*; D004279:DNA, Viral / Q000302:isolation & purification; D004751:Enteritis / Q000209:etiology* / Q000821:virology; D005260:Female; D006086:Graft vs Host Disease; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008297:Male; D012307:Risk Factors; D055815:Young Adult
chemical_list: D004279:DNA, Viral