title: Synthesis of 2'-substituted inosine analogs via unusual masking of the 6-hydroxyl group.
abstract: 2'-Modified inosine analogs have been synthesized from 6-chloropurine riboside via 6-dimethylaminopurine or 6-benzyloxypurine intermediates. The dimethylaminopurine intermediate was obtained via an unusually facile dimethylamine transfer from dimethylformamide.    Graphical Abstract:
authors.affiliation: Department of Pharmaceutical Sciences, Medical University of South Carolina, Charleston, South Carolina, USA.
authors.forename: Fabio
authors.initials: F
authors.lastname: Casu
authors.forename: Rebecca K
authors.initials: RK
authors.lastname: Harston
authors.forename: Maria A
authors.initials: MA
authors.lastname: Chiacchio
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Gumina
mesh_terms: D017665:Hydroxyl Radical / Q000737:chemistry*; D007288:Inosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D017665:Hydroxyl Radical; D007288:Inosine