title: Total synthesis of COPD biomarker desmosine that crosslinks elastin.
abstract: Desmosine, a crosslinking amino acid of elastin, is an attractive biomarker for diagnosis of chronic obstructive pulmonary disease (COPD). In this study, the first total synthesis of (+)-desmosine was achieved in 11% overall yield in 13 steps utilizing stepwise and regioselective Sonogashira cross-coupling reactions.
authors.affiliation: Department of Materials and Life Sciences, Faculty of Science and Technology, Sophia University, 7-1 Kioicho, Tokyo 102-8554, Japan. t-usuki@sophia.ac.jp
authors.forename: Toyonobu
authors.initials: T
authors.lastname: Usuki
authors.forename: Haruka
authors.initials: H
authors.lastname: Yamada
authors.forename: Takahiro
authors.initials: T
authors.lastname: Hayashi
authors.forename: Hiroto
authors.initials: H
authors.lastname: Yanuma
authors.forename: Yohei
authors.initials: Y
authors.lastname: Koseki
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Suzuki
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Masuyama
authors.forename: Yong Y
authors.initials: YY
authors.lastname: Lin
mesh_terms: D015415:Biomarkers / Q000737:chemistry; D003432:Cross-Linking Reagents / Q000138:chemical synthesis* / Q000737:chemistry; D003895:Desmosine / Q000138:chemical synthesis* / Q000737:chemistry; D004549:Elastin / Q000737:chemistry*; D015394:Molecular Structure; D029424:Pulmonary Disease, Chronic Obstructive / Q000175:diagnosis*; D013237:Stereoisomerism
chemical_list: D015415:Biomarkers; D003432:Cross-Linking Reagents; D003895:Desmosine; D004549:Elastin