title: Permanent implantation of iodine-125 seeds as a salvage therapy for recurrent head and neck carcinoma after radiotherapy.
abstract: Seventeen patients with head and neck recurrent carcinoma underwent (125)I seed implantation under CT or ultrasound guidance. The actuarial D90 of the (125)I seeds implanted was 90-160 Gy (median, 126 Gy). Median follow-up was 10 months (range, 3-48 months). The median local control time was 16 months; the 1- and 2-year local control rates were 66.5% and 49.9%, respectively. The 1- and 2-year survival rates were 51.3% and 38.5%, respectively (median, 16 months). None of the patients experienced grade 4 toxicity. (125)I seed implantation was a feasible and effective salvage treatment for patients with recurrent head and neck cancers.
authors.affiliation: Department of Radiation Oncology, Peking University 3rd Hospital, Beijing, China.
authors.forename: Na
authors.initials: N
authors.lastname: Meng
authors.forename: Yu Liang
authors.initials: YL
authors.lastname: Jiang
authors.forename: Jun Jie
authors.initials: JJ
authors.lastname: Wang
authors.forename: Wei Qiang
authors.initials: WQ
authors.lastname: Ran
authors.forename: Hui Shu
authors.initials: HS
authors.lastname: Yuan
authors.forename: Ang
authors.initials: A
authors.lastname: Qu
authors.forename: Ping
authors.initials: P
authors.lastname: Jiang
authors.forename: Rui Jie
authors.initials: RJ
authors.lastname: Yang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy / Q000379:methods*; D005260:Female; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000532:radiotherapy*; D006801:Humans; D007457:Iodine Radioisotopes / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000532:radiotherapy*; D061089:Radiotherapy, Image-Guided; D016879:Salvage Therapy; D015996:Survival Rate
chemical_list: D007457:Iodine Radioisotopes