title: [Intima-media thickness and left ventricle remodeling in patients with prehypertension and impaired glucose tolerance].
abstract: OBJECTIVE
  To investigate the intima-media thickness and cardiac remodeling in patients with prehypertension and impaired glucose tolerance.
  
  
  METHODS
  Three-hundred patients were divided into four groups: normal control (NC, n = 61), prehypertension (PH, n = 83), impaired glucose tolerance (IGT, n = 91), prehypertension and impaired glucose tolerance (PH + IGT, n = 65). Intima-media thickness (IMT) was measured by doppler ultrasonography. Left ventricle mess (LVMI), midwall fractional shortening (mFS), peakE/peakA (E/A) were measured by echocardiography.
  
  
  RESULTS
  (1) IMT was significantly increased in PH, IGT and PH + IGT groups than in NC group [(0.7 ± 0.1) mm, (0.7 ± 0.1) mm and (1.0 ± 0.1) mm vs.(0.6 ± 0.1) mm, all P < 0.01], which was significantly high in PH + IGT group than in PH or IGT group. Regression analysis demonstrated that high-sensitivity C-reactive protein (hs-CRP), 2-hour postprandial blood glucose (2hPBG), systolic pressure (SBP), diastolic blood pressure (DBP) were independent predictors to increased IMT. (2) LVMI was higher in PH and PH + IGT groups than in NC group [(97.0 ± 3.3) g/m(2), (97.1 ± 2.8) g/m(2) vs.(87.0 ± 2.0) g/m(2), (87.9 ± 1.5) g/m(2), all P < 0.01], and positively related with SBP, DBP. (3) mFS was lower in PH and PH + IGT groups [(14.0 ± 0.8)%, (14.0 ± 0.8)% vs. (18.3 ± 1.0)%, (18.2 ± 0.5)%, P < 0.01], negatively related with SBP and DBP. E/A was similar among groups and lower E/A was associated with higher SBP.
  
  
  CONCLUSIONS
  Vascular and left ventricular structure remodeling and systolic dysfunction could be detected in prehypertension patients. Impaired glucose tolerance could enhance vascular remodeling in prehypertension patients.
authors.affiliation: Department of Cardiology, Shanxi Medical University, Taiyuan 030001, China. wangruiying9@sina.com
authors.forename: Rui-ying
authors.initials: RY
authors.lastname: Wang
authors.forename: Qiong
authors.initials: Q
authors.lastname: Guo
authors.forename: Xian
authors.initials: X
authors.lastname: Yang
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.forename: Shu-tian
authors.initials: ST
authors.lastname: Huang
mesh_terms: D000368:Aged; D059168:Carotid Intima-Media Thickness; D016022:Case-Control Studies; D005260:Female; D018149:Glucose Intolerance; D006801:Humans; D008297:Male; D008875:Middle Aged; D058246:Prehypertension / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology*; D020257:Ventricular Remodeling