title: A novel view of paroxysmal nocturnal hemoglobinuria pathogenesis: more motile PNH hematopoietic stem/progenitor cells displace normal HSPCs from their niches in bone marrow due to defective adhesion, enhanced migration and mobilization in response to erythrocyte-released sphingosine-1 phosphate gradient.
authors.forename: J
authors.initials: J
authors.lastname: Ratajczak
authors.forename: M
authors.initials: M
authors.lastname: Kucia
authors.forename: K
authors.initials: K
authors.lastname: Mierzejewska
authors.forename: R
authors.initials: R
authors.lastname: Liu
authors.forename: C H
authors.initials: CH
authors.lastname: Kim
authors.forename: N
authors.initials: N
authors.lastname: Natarajan
authors.forename: V
authors.initials: V
authors.lastname: Sharma
authors.forename: D M
authors.initials: DM
authors.lastname: Miller
authors.forename: J
authors.initials: J
authors.lastname: Maciejewski
authors.forename: M Z
authors.initials: MZ
authors.lastname: Ratajczak
mesh_terms: D000328:Adult; D000368:Aged; D001853:Bone Marrow / Q000378:metabolism / Q000473:pathology*; D002448:Cell Adhesion; D002465:Cell Movement; D002478:Cells, Cultured; D004912:Erythrocytes / Q000166:cytology / Q000378:metabolism*; D019650:Hematopoietic Stem Cell Mobilization; D006412:Hematopoietic Stem Cells / Q000473:pathology*; D006457:Hemoglobinuria, Paroxysmal / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008246:Lysophospholipids / Q000378:metabolism*; D008875:Middle Aged; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000378:metabolism; D055815:Young Adult
chemical_list: D008246:Lysophospholipids; C060506:sphingosine 1-phosphate; D013110:Sphingosine