title: Palladium-catalyzed regio- and stereoselective hydrosilylation of electron-deficient alkynes.
abstract: Highly regio- and stereoselective hydrosilylation applicable to a broad range of electron-deficient alkynes has been established using palladium catalysis. The synthetic utility of the method has been demonstrated by further transformations of α-silylalkenes, particularly Hiyama coupling and stereoinverting iododesilylation followed by Suzuki-Miyaura coupling, which enables stereodivergent syntheses of α-arylenoates.
authors.affiliation: Laboratory of Chemical Biology, Graduate School of Biomedical Science, Institute of Biomaterials and Bioengineerings, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan.
authors.forename: Yuto
authors.initials: Y
authors.lastname: Sumida
authors.forename: Tomoe
authors.initials: T
authors.lastname: Kato
authors.forename: Suguru
authors.initials: S
authors.lastname: Yoshida
authors.forename: Takamitsu
authors.initials: T
authors.lastname: Hosoya
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis / Q000737:chemistry; D000480:Alkynes / Q000737:chemistry*; D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D012821:Silanes / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D000480:Alkynes; D002264:Carboxylic Acids; D012821:Silanes; D010165:Palladium