title: Is short course of antimicrobial therapy for asymptomatic bacteriuria before urologic surgical procedures sufficient?
abstract: BACKGROUND
  Duration of treatment of asymptomatic bacteriuria for patients undergoing urologic surgical procedures is undetermined. We compared the efficacy of long- versus short-course antimicrobial treatment in patients with asymptomatic bacteriuria undergoing urologic surgical procedures.
  
  
  METHODS
  Patients were divided into two groups according to duration of antimicrobial treatment. Group A patients received a single dose of an appropriate antibiotic, determined by antimicrobial sensitivity testing, 30 to 60 minutes before the surgical procedure. If a urinary catheter was placed postoperatively, a second dose was given following the recommended dose interval. Group B patients received antimicrobial treatment prior to surgery at least until patient urine became sterile. All patients were monitored for signs and symptoms of septicemia following surgical procedures.
  
  
  RESULTS
  None of the patients enrolled in the study developed infectious complications such as sepsis or upper urinary tract infection. In group A, 31 patients were treated with antimicrobials before 39 urological procedures. In group B, the mean treatment time for 28 patients before 30 urological procedures was 8.03 ± 3.86 days. There were also significant differences in length of stay and the cost of antimicrobial therapy between the groups (P < 0.0001). Isolation of an increased number of resistant microorganisms was associated with long course therapy in group B.
  
  
  CONCLUSIONS
  Short course therapy protocol may be a practical, simple approach for antibiotic use; it decreases hospital stays, eliminates delayed procedure times, lowers the economic cost of antimicrobials and lessens the chance of superinfection with and spread of antimicrobial resistant microorganisms.
authors.affiliation: Department of Infectious Diseases and Clinical Microbiology, Pamukkale University, Denizli, Turkey. sayinkutlu@yahoo.com
authors.forename: Selda
authors.initials: S
authors.lastname: Sayin Kutlu
authors.forename: Zafer
authors.initials: Z
authors.lastname: Aybek
authors.forename: Koray
authors.initials: K
authors.lastname: Tekin
authors.forename: Demet
authors.initials: D
authors.lastname: Okke
authors.forename: Serife
authors.initials: S
authors.lastname: Akalin
authors.forename: Serkan
authors.initials: S
authors.lastname: Altintas
authors.forename: Melek
authors.initials: M
authors.lastname: Demir
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D001437:Bacteriuria / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D011300:Preoperative Care / Q000379:methods*; D018805:Sepsis / Q000517:prevention & control*; D013997:Time Factors; D016896:Treatment Outcome; D013520:Urologic Surgical Procedures / Q000379:methods*
chemical_list: D000890:Anti-Infective Agents