title: Short communication: RNASEL alleles and susceptibility to infection by human retroviruses and hepatitis viruses.
abstract: RNASEL seems to function as an intracellular restriction factor blocking the establishment of infections caused by viral agents. Herein, we investigated whether allelic variants at the RNASEL gene might influence the susceptibility to viral infections or conditions potentially linked to viral agents. The allelic distribution at codon 462 was 139 (33.9%), 204 (49.8%), and 67 (16.3%) for RR, RQ, and QQ, respectively, in 410 individuals in Spain. There were no significant differences comparing 105 blood donors and 71 patients with HIV-1 infection, 27 with chronic hepatitis C, 67 with prostate cancer, and 107 with chronic fatigue syndrome. In contrast, two-thirds of 18 patients with HTLV-1 infection and 15 with chronic hepatitis B harbored RR. Thus, polymorphisms at the RNASEL gene do not seem to influence the susceptibility to common viral infections or conditions potentially of viral etiology. The role in influencing the susceptibility to HTLV-1 or HBV chronic infection warrants further examination in larger patient populations.
authors.affiliation: Infectious Diseases Department, Hospital Carlos III, Madrid, Spain.
authors.forename: Miguel
authors.initials: M
authors.lastname: Arredondo
authors.forename: Fermín
authors.initials: F
authors.lastname: de Bethencourt
authors.forename: Ana
authors.initials: A
authors.lastname: Treviño
authors.forename: Antonio
authors.initials: A
authors.lastname: Collado
authors.forename: Pilar
authors.initials: P
authors.lastname: Torres
authors.forename: Luz
authors.initials: L
authors.lastname: Barbolla
authors.forename: Vincent
authors.initials: V
authors.lastname: Soriano
authors.forename: Carmen
authors.initials: C
authors.lastname: de Mendoza
mesh_terms: D000483:Alleles; D001782:Blood Donors; D004722:Endoribonucleases / Q000235:genetics* / Q000276:immunology; D015673:Fatigue Syndrome, Chronic / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006679:HIV Seropositivity / Q000235:genetics* / Q000276:immunology; D015497:HIV-1 / Q000235:genetics / Q000276:immunology*; D019694:Hepatitis B, Chronic / Q000235:genetics* / Q000276:immunology; D019698:Hepatitis C, Chronic / Q000235:genetics* / Q000276:immunology; D015368:Human T-lymphotropic virus 1 / Q000235:genetics / Q000276:immunology*; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D011471:Prostatic Neoplasms / Q000235:genetics; D012367:RNA, Viral / Q000378:metabolism; D013030:Spain
chemical_list: D012367:RNA, Viral; D004722:Endoribonucleases; C031956:2-5A-dependent ribonuclease