title: Redox-mediated programed death of myocardial cells after cardiac arrest and cardiopulmonary resuscitation.
abstract: Besides the fact that prolonged whole-body ischemia causes tissue and organ injury during cardiac arrest, additional damage occurs after the restoration of spontaneous circulation, during which the reperfusion activates a host of intracellular responses. These responses may lead to an increased threshold of oxidant-mediated injury and redox-mediated programed cell death in the stunned myocardium. The aim of this article is to summarize the major intracellular responses occurring from the onset of cardiac arrest until the post-resuscitation period that may lead to redox-mediated programed death of myocardial cells.
authors.affiliation: Department of Anatomy, Medical School, National and Kapodistrian University of Athens, Athens, Greece. thanoschalkias@yahoo.gr
authors.forename: Athanasios
authors.initials: A
authors.lastname: Chalkias
authors.forename: Theodoros
authors.initials: T
authors.lastname: Xanthos
mesh_terms: D016887:Cardiopulmonary Resuscitation / Q000009:adverse effects*; D016923:Cell Death; D006323:Heart Arrest / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D015428:Myocardial Reperfusion Injury / Q000209:etiology; D032383:Myocytes, Cardiac / Q000473:pathology*; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism; D010313:Partial Pressure
chemical_list: D010100:Oxygen