title: [Risk factors and pathogen distribution in premature infants with nosocomial sepsis].
abstract: OBJECTIVE
  To investigate the main risk factors and pathogen distribution of nosocomial sepsis among premature infants.
  
  
  METHODS
  The clinical data of 3418 hospitalized premature infants from January 2003 to December 2010 were retrospectively analyzed for the risk factors and pathogen distribution of nosocomial sepsis.
  
  
  RESULTS
  The incidence of neonatal nosocomial sepsis was 3.10% (106/3418), and the median age at diagnosis of neonatal nosocomial sepsis was 19 (4-48) days. The major pathogens of the infections among these premature infants included gram-positive bacteria (45.2%), especially coagulase-negative Staphylococcus (24.3%), and gram-negative bacteria (41.7%), especially Klebsiella pneumoniae (25.2%), as well as fungus (13.0%). Logistic regression analysis showed that the main risk factors included low birth weight, retention of central venous catheters, and long duration of parenteral nutrition (OR: 3.765, 3.051, and 2.998, respectively; P<0.05).
  
  
  CONCLUSIONS
  Low birth weight, retention of central venous catheters, and long duration of parenteral nutrition are the main risk factors for neonatal nosocomial sepsis, whereas the leading pathogen is Klebsiella pneumoniae.
authors.affiliation: Department of Neonatology, Second Clinical Medical College of Jinan University, Shenzhen, Guandong, China. wujun731115@163.com
authors.forename: Jun
authors.initials: J
authors.lastname: Wu
authors.forename: Ben-Qing
authors.initials: BQ
authors.lastname: Wu
authors.forename: Jin-Jie
authors.initials: JJ
authors.lastname: Huang
authors.forename: Liang
authors.initials: L
authors.lastname: Luo
authors.forename: Yi
authors.initials: Y
authors.lastname: Tang
mesh_terms: D001419:Bacteria / Q000302:isolation & purification; D001724:Birth Weight; D002405:Catheterization, Central Venous / Q000009:adverse effects; D003428:Cross Infection / Q000209:etiology* / Q000382:microbiology; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D016015:Logistic Models; D008297:Male; D010288:Parenteral Nutrition / Q000009:adverse effects; D012189:Retrospective Studies; D012307:Risk Factors; D018805:Sepsis / Q000209:etiology* / Q000382:microbiology