title: PASADENA hyperpolarized 13C phospholactate.
abstract: We demonstrate that potassium 1-(13)C-phosphoenolpyruvate becomes hyperpolarized potassium 1-(13)C-phospholactate with (13)C T(1) = 36 s after molecular hydrogenation by PASADENA (Parahydrogen and Synthesis Allows Dramatically Enhanced Nuclear Alignment). This proof-of-principle study was conducted with a fully protonated molecular precursor. (13)C was polarized to a level of 1%, corresponding to nearly 4000-fold sensitivity enhancement at 3 T. The relevant homo- and heteronuclear spin-spin couplings are reported.
authors.affiliation: Department of Radiology, Vanderbilt University Institute of Imaging Science (VUIIS), Nashville, Tennessee 37232, USA.
authors.forename: Roman V
authors.initials: RV
authors.lastname: Shchepin
authors.forename: Aaron M
authors.initials: AM
authors.lastname: Coffey
authors.forename: Kevin W
authors.initials: KW
authors.lastname: Waddell
authors.forename: Eduard Y
authors.initials: EY
authors.lastname: Chekmenev
mesh_terms: D002247:Carbon Isotopes; D007773:Lactates / Q000138:chemical synthesis / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000592:standards; D015394:Molecular Structure; D011188:Potassium / Q000737:chemistry; D012015:Reference Standards
chemical_list: D002247:Carbon Isotopes; D007773:Lactates; D011188:Potassium