title: Regulation of endocytosis by the small GTP-ase Rab5.
abstract: Rab5 is a small GTPase associated with the plasma membrane and the early endosomes. Expression of wild type rab5 and a mutant protein defective in GTP-binding in BHK cells led to alterations in the rate of endocytosis and in the morphology of endocytic organelles. The results obtained suggest that rab5 is a rate limiting GTPase that regulate the kinetics of both lateral fusion of early endosomes and fusion of plasma membrane-derived endocytic vesicles with early endosomes.
authors.affiliation: European Molecular Biology Laboratory, Meyerhofstrasse 1, Postfach 10.2209, D-6900, Heidelberg, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Zerial