title: [A multi-center randomized controlled trial of intrauterine device use in Chinese women].
abstract: OBJECTIVE
  To assess the safety and effectiveness of intrauterine device in Chinese women.
  
  
  METHODS
  In this multicenter randomized controlled trial, a total of 24 000 women were randomly (1:1:1) into 3 groups of Yuangong Cu 365 (YCu365), Copper T 380A (TCu380A) and Multiload Cu 375 (MLCu375). Clinical outcomes were assessed at 12 months post-insertion, including discontinuation due to pregnancy, expulsion, hemorrhage and downward displacement, etc. The overall and causal-specific discontinuation rates for adverse events were calculated.
  
  
  RESULTS
  At the end of the first year, the discontinuation rate of YCu365 (4.21%) was the lowest, followed by TCu380A (8.42%) and MLCu375 (13.91%) (P < 0.01). The differences of discontinuation rates for pregnancy, expulsion, hemorrhage and downward displacement between these IUDs were also significant. MLCu375, side effect without medical treatment, fewer follow-ups, deeper uterine cavity and previous IUD failure were significantly associated with an increased risk of IUD discontinuation.
  
  
  CONCLUSIONS
  The newly developed indomethacin-releasing YCu365 IUD appears to perform the best. However, its long-term safety and cost-effectiveness should be further evaluated.
authors.affiliation: Jiangsu Institute of Planned Parenthood Research, Nanjing, China. liying2008@jsmail.com.cn
authors.forename: Ying
authors.initials: Y
authors.lastname: Li
authors.forename: Su-min
authors.initials: SM
authors.lastname: Zhang
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
authors.forename: Chun-yan
authors.initials: CY
authors.lastname: Zhang
authors.forename: You-ping
authors.initials: YP
authors.lastname: Li
authors.forename: Jian
authors.initials: J
authors.lastname: Zhou
authors.forename: Peng-cheng
authors.initials: PC
authors.lastname: Xun
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhao
authors.forename: Lei
authors.initials: L
authors.lastname: Ba
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Yu-lin
authors.initials: YL
authors.lastname: Wu
authors.forename: Jin-xun
authors.initials: JX
authors.lastname: Xu
authors.forename: Sen-quan
authors.initials: SQ
authors.lastname: Yu
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Yu-jun
authors.initials: YJ
authors.lastname: Zhang
authors.forename: Guo-bin
authors.initials: GB
authors.lastname: Yu
authors.forename: Ai-hua
authors.initials: AH
authors.lastname: Fang
authors.forename: Jiang-tao
authors.initials: JT
authors.lastname: Huang
authors.forename: Ai-ping
authors.initials: AP
authors.lastname: Tian
authors.forename: He-ping
authors.initials: HP
authors.lastname: Chen
mesh_terms: D000328:Adult; D044466:Asian People; D005260:Female; D006801:Humans; D007435:Intrauterine Devices, Copper / Q000009:adverse effects; D055815:Young Adult