title: Palladium and copper cocatalyzed tandem N-H/C-H Bond functionalization: synthesis of CF3-containing indolo- and pyrrolo[2,1-a]isoquinolines.
abstract: A palladium- and copper-catalyzed tandem N-H/C-H bond functionalization reaction of ortho-(2-chlorovinyl)bromobenzenes with indoles and pyrroles has been developed. A variety of CF(3)-containing indolo- and pyrrolo[2,1-a]isoquinolines were prepared in moderate to good yields via the cyclization of 1-bromo-2-(2-chloro-3,3,3-trifluoroprop-1-enyl)benzenes with indoles and pyrroles.
authors.affiliation: College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325035, China.
authors.forename: Lei-Lei
authors.initials: LL
authors.lastname: Sun
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Liao
authors.forename: Ri-Yuan
authors.initials: RY
authors.lastname: Tang
authors.forename: Chen-Liang
authors.initials: CL
authors.lastname: Deng
authors.forename: Xing-Guo
authors.initials: XG
authors.lastname: Zhang
mesh_terms: D001969:Bromobenzenes / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D001969:Bromobenzenes; D007211:Indoles; D007546:Isoquinolines; D011758:Pyrroles; D010165:Palladium; D003300:Copper