title: New isoprenylated flavones and stilbene derivative from Artocarpus hypargyreus.
abstract: Three new isoprenylated flavones, hypargyflavones A-C (1-3, resp.), and one novel stilbene derivative, hypargystilbene A (4), together with seven known compounds, 5-11, were isolated from the stems of Artocarpus hypargyreus Hance. The structures were elucidated by spectroscopic methods. Hypargyflavone A (1), cudraflavone C (8), brosimone I (10), and norartocarpin (11) showed inhibitory effects on pancreatic lipase.
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Fudan University, 826 Zhang Heng Road, Shanghai 201203, PR China.
authors.forename: Mei-Hua
authors.initials: MH
authors.lastname: Yu
authors.forename: Ting
authors.initials: T
authors.lastname: Zhao
authors.forename: Gui-Rui
authors.initials: GR
authors.lastname: Yan
authors.forename: Hong-Xun
authors.initials: HX
authors.lastname: Yang
authors.forename: He-Yao
authors.initials: HY
authors.lastname: Wang
authors.forename: Ai-Jun
authors.initials: AJ
authors.lastname: Hou
mesh_terms: D031622:Artocarpus / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D047309:Flavones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D008049:Lipase / Q000037:antagonists & inhibitors / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D054876:Prenylation; D013267:Stilbenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D004791:Enzyme Inhibitors; D047309:Flavones; D010936:Plant Extracts; D013267:Stilbenes; D008049:Lipase; C518354:PNLIP protein, human