title: Genetic variation in cell death genes and risk of non-Hodgkin lymphoma.
abstract: BACKGROUND
  Non-Hodgkin lymphomas are a heterogeneous group of solid tumours that constitute the 5(th) highest cause of cancer mortality in the United States and Canada. Poor control of cell death in lymphocytes can lead to autoimmune disease or cancer, making genes involved in programmed cell death of lymphocytes logical candidate genes for lymphoma susceptibility.
  
  
  METHODS
  We tested for genetic association with NHL and NHL subtypes, of SNPs in lymphocyte cell death genes using an established population-based study. 17 candidate genes were chosen based on biological function, with 123 SNPs tested. These included tagSNPs from HapMap and novel SNPs discovered by re-sequencing 47 cases in genes for which SNP representation was judged to be low. The main analysis, which estimated odds ratios by fitting data to an additive logistic regression model, used European ancestry samples that passed quality control measures (569 cases and 547 controls). A two-tiered approach for multiple testing correction was used: correction for number of tests within each gene by permutation-based methodology, followed by correction for the number of genes tested using the false discovery rate.
  
  
  RESULTS
  Variant rs928883, near miR-155, showed an association (OR per A-allele: 2.80 [95% CI: 1.63-4.82]; p(F) = 0.027) with marginal zone lymphoma that is significant after correction for multiple testing.
  
  
  CONCLUSIONS
  This is the first reported association between a germline polymorphism at a miRNA locus and lymphoma.
authors.affiliation: Canada's Michael Smith Genome Sciences Centre, BC Cancer Agency, Vancouver, British Columbia, Canada.
authors.forename: Johanna M
authors.initials: JM
authors.lastname: Schuetz
authors.forename: Denise
authors.initials: D
authors.lastname: Daley
authors.forename: Jinko
authors.initials: J
authors.lastname: Graham
authors.forename: Brian R
authors.initials: BR
authors.lastname: Berry
authors.forename: Richard P
authors.initials: RP
authors.lastname: Gallagher
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Connors
authors.forename: Randy D
authors.initials: RD
authors.lastname: Gascoyne
authors.forename: John J
authors.initials: JJ
authors.lastname: Spinelli
authors.forename: Angela R
authors.initials: AR
authors.lastname: Brooks-Wilson
mesh_terms: D016923:Cell Death / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006801:Humans; D016015:Logistic Models; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics* / Q000473:pathology; D035683:MicroRNAs / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D044465:White People
chemical_list: D035683:MicroRNAs