title: Glutamate receptors in synaptic assembly and plasticity: case studies on fly NMJs.
abstract: The molecular and cellular mechanisms that control the composition and functionality of ionotropic glutamate receptors may be considered as most important "set screws" for adjusting excitatory transmission in the course of developmental and experience-dependent changes within neural networks. The Drosophila larval neuromuscular junction has emerged as one important invertebrate model system to study the formation, maintenance, and plasticity-related remodeling of glutamatergic synapses in vivo. By exploiting the unique genetic accessibility of this organism combined with diverse tools for manipulation and analysis including electrophysiology and state of the art imaging, considerable progress has been made to characterize the role of glutamate receptors during the orchestration of junctional development, synaptic activity, and synaptogenesis. Following an introduction to basic features of this model system, we will mainly focus on conceptually important findings such as the selective impact of glutamate receptor subtypes on the formation of new synapses, the coordination of presynaptic maturation and receptor subtype composition, the role of nonvesicularly released glutamate on the synaptic localization of receptors, or the homeostatic feedback of receptor functionality on presynaptic transmitter release.
authors.affiliation: Leibniz Institute for Neurobiology, Brenneckestr. 6, 39118 Magdeburg, Germany. thomas@ifn-magdeburg.de
authors.forename: Ulrich
authors.initials: U
authors.lastname: Thomas
authors.forename: Stephan J
authors.initials: SJ
authors.lastname: Sigrist
mesh_terms: D000818:Animals; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism; D004331:Drosophila melanogaster / Q000502:physiology*; D018698:Glutamic Acid / Q000378:metabolism*; D007814:Larva / Q000502:physiology; D009469:Neuromuscular Junction / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology; D009474:Neurons / Q000502:physiology; D017470:Receptors, Glutamate / Q000502:physiology*; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology*
chemical_list: D029721:Drosophila Proteins; D017470:Receptors, Glutamate; D018698:Glutamic Acid