title: [Study on protective effect of Tianji soft capsule on blood lipids, internal antioxidant system and vascular endothelial system in hyperlipidemia rats].
abstract: OBJECTIVE
  To study the protective effects of Tianji soft capsule (TJSC) on blood lipids, internal antioxidant system and vascular endothelial system in hyperlipidemia rats.
  
  
  METHODS
  Seventy two healthy male rats were divided into six groups. The rats in control group were administered with ordinary diet. The rats in model group were fed with high cholesterol/lipid diet to induce hyperlipidemia. The rats in TJSC and CoQ10 groups were fed with high cholesterol/lipid diet, and treated with TJSC at different doses of 83 (low-dose group, L), 250 (middle-dose group, M), 750 (high-dose group, H) mg/kg, and CoQ10 at the dose of 83 mg/kg, respectively. All animals were put to death after four weeks, effects on lipid level; antioxidant system and endothelial system were evaluated through detection of total cholesterol (TC), triglyceride (TG), very low density lipoprotein (VLDL), atherogenic index (AI), malondidehyde (MDA) and plasma endothelin (ET), HDL/TC ratio, activities of superoxide dismutase (SOD) and nitric oxide (NO).
  
  
  RESULTS
  Compared with model group, serum TC, TG, VLDL, AI, MDA and ET reduced and the HDL/TC ratio increased, meanwhile activities of SOD and NO were enhanced.
  
  
  CONCLUSIONS
  TJSC can regulate the lipid metabolism, enhance antioxidant system and protect the vascular endothelia system in hyperlipiemic rats.
authors.affiliation: Department of Nutrition and Food Hygiene, West China School of Public Health, Sichuan University, Chengdu 610041, China.
authors.forename: Hai-ying
authors.initials: HY
authors.lastname: Ma
authors.forename: Jin-yao
authors.initials: JY
authors.lastname: Chen
authors.forename: Li-shi
authors.initials: LS
authors.lastname: Zhang
mesh_terms: D000818:Animals; D004041:Dietary Fats / Q000008:administration & dosage; D004339:Drug Compounding; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D016232:Endothelins / Q000378:metabolism; D004730:Endothelium, Vascular / Q000378:metabolism*; D031281:Hippophae / Q000737:chemistry; D006949:Hyperlipidemias / Q000097:blood / Q000378:metabolism / Q000517:prevention & control*; D008055:Lipids / Q000097:blood*; D008297:Male; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D029771:Rhodiola / Q000737:chemistry; D013482:Superoxide Dismutase / Q000378:metabolism*
chemical_list: D004041:Dietary Fats; D004365:Drugs, Chinese Herbal; D016232:Endothelins; D008055:Lipids; D013482:Superoxide Dismutase