title: Good neighbours in the tumour stroma reduce oxidative stress.
abstract: Tumour cells undergo oncogene-regulated metabolic reprogramming that maximizes survival and growth. However, little is known about metabolic interactions between tumour cells and their non-malignant neighbours in the stroma. Bone-marrow-derived stromal cells are now shown to provide cysteine, an essential nutrient that enables leukaemia cells to resist oxidative stress.
authors.affiliation: University of Texas, Southwestern Medical Center, Children's Research Institute, Dallas, Texas 75390-8502, USA. ralph.deberardinis@utsouthwestern.edu
authors.forename: Ralph J
authors.initials: RJ
authors.lastname: DeBerardinis
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000378:metabolism*; D003553:Cystine / Q000378:metabolism*; D005978:Glutathione / Q000096:biosynthesis*; D006801:Humans; D017154:Stromal Cells / Q000378:metabolism*
chemical_list: D003553:Cystine; D005978:Glutathione