title: Assessing two spirometric criteria of pre-bronchodilator and post-bronchodilator FEV1/FVC ratio in detecting air flow obstruction.
abstract: OBJECTIVE
  To assess the Pre-bronchodilator criteria and the Post-bronchodilator criteria of FEV1/FVC ratio in diagnosing Airflow obstruction.
  
  
  METHODS
  An observational study was conducted from 1988 to 2006 at the Aga Khan University Hospital Patients referred to the pulmonary function test laboratory for spirometry with bronchodilator reversibility at the hospital during the above said period were enrolled. Forced spirometry was performed according to ATS guidelines. All patients who had pre-bronchodilator criteria of airflow obstruction were analyzed and compared with the post bronchodilator criteria.
  
  
  RESULTS
  A total of 4222 individuals underwent spirometry out of which 4072 individuals were studied. Using the pre bronchodilator criteria, 1375 (34%) patients had airflow obstruction. Applying the post bronchodilator criteria on the same patients, 1098 (27%) had evidence of airway obstruction. Out of these 1375 patients who had airflow obstruction by using pre-bronchodilator criteria, 277 (20%) patients had no airflow obstruction by using the post bronchodilator criteria. Out of these 277 patients, 52% had significant airways reversibility as evidenced by >12% increase in their FEV1 pre and post bronchodilator.
  
  
  CONCLUSIONS
  Pre bronchodilator criteria for detection of airflow obstruction overestimate the diagnosis of airflow obstruction and by using post bronchodilator criteria for airway obstruction on spirometry, decreases this over diagnosis of the condition
authors.affiliation: Section of Pulmonary & Critical Care Medicine, Department of Medicine, The Aga Khan University Hospital, Karachi, Pakistan.
authors.forename: Zeeshan
authors.initials: Z
authors.lastname: Waheed
authors.forename: Muhammad
authors.initials: M
authors.lastname: Irfan
authors.forename: Ahmed Suleman
authors.initials: AS
authors.lastname: Haque
authors.forename: Najmul Hasan
authors.initials: NH
authors.lastname: Siddiqui
authors.forename: Safia
authors.initials: S
authors.lastname: Awan
authors.forename: Beenish
authors.initials: B
authors.lastname: Syed
authors.forename: Javaid Ahmed
authors.initials: JA
authors.lastname: Khan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000402:Airway Obstruction / Q000175:diagnosis* / Q000503:physiopathology; D001993:Bronchodilator Agents; D002000:Bronchospirometry / Q000379:methods; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D014797:Vital Capacity / Q000187:drug effects / Q000502:physiology; D055815:Young Adult
chemical_list: D001993:Bronchodilator Agents