title: Multicentre investigation on electrically evoked compound action potential and stapedius reflex: how do these objective measures relate to implant programming parameters?
abstract: OBJECTIVE
  The aims of this study were to collect data on electrically evoked compound action potential (eCAP) and electrically evoked stapedius reflex thresholds (eSRT) in HiResolution(TM) cochlear implant (CI) users, and to explore the relationships between these  objective measures and behavioural measures of comfort levels (M-levels).
  
  
  METHODS
  A prospective study on newly implanted subjects was designed. The eCAP was measured intra-operatively and at first fitting through neural response imaging (NRI), using the SoundWave(TM)  fitting software. The eSRT was measured intra-operatively by visual monitoring of the stapes, using both single-electrode stimulation and speech bursts (four electrodes stimulated at the same time). Measures of M-levels were performed according to standard clinical practice and collected  at first fitting, 3 and 6 months of CI use.
  
  
  RESULTS
  One hundred seventeen subjects from 14 centres, all implanted unilaterally with a HiResolution CII Bionic Ear(®) or HiRes 90K(®), were included in the study. Speech burst stimulation elicited a  significantly higher eSRT success rate than single-electrode stimulation, 84 vs. 64% respectively. The NRI success rate was 81% intra-operatively, significantly increasing to 96% after 6 months. Fitting guidelines were defined on the basis of a single NRI measurement. Correlations, analysis  of variance, and multiple regression analysis were applied to generate a predictive model for the M-levels.
  
  
  CONCLUSIONS
  Useful insights were produced into the behaviour of objective measures according to time, electrode location, and fitting parameters. They may usefully  assist in programming the CI when no reliable feedback is obtained through standard behavioural procedures.
authors.affiliation: Hôpital Robert Debré, Paris, France.
authors.forename: Thierry
authors.initials: T
authors.lastname: Van Den Abbeele
authors.forename: Nathalie
authors.initials: N
authors.lastname: Noël-Petroff
authors.forename: Istemihan
authors.initials: I
authors.lastname: Akin
authors.forename: Gül
authors.initials: G
authors.lastname: Caner
authors.forename: Levent
authors.initials: L
authors.lastname: Olgun
authors.forename: Jeanne
authors.initials: J
authors.lastname: Guiraud
authors.forename: Eric
authors.initials: E
authors.lastname: Truy
authors.forename: Josef
authors.initials: J
authors.lastname: Attias
authors.forename: Eyal
authors.initials: E
authors.lastname: Raveh
authors.forename: Erol
authors.initials: E
authors.lastname: Belgin
authors.forename: Gonca
authors.initials: G
authors.lastname: Sennaroglu
authors.forename: Dietmar
authors.initials: D
authors.lastname: Basta
authors.forename: Arneborg
authors.initials: A
authors.lastname: Ernst
authors.forename: Alessandro
authors.initials: A
authors.lastname: Martini
authors.forename: Monica
authors.initials: M
authors.lastname: Rosignoli
authors.forename: Haya
authors.initials: H
authors.lastname: Levi
authors.forename: Joseph
authors.initials: J
authors.lastname: Elidan
authors.forename: Abdelhamid
authors.initials: A
authors.lastname: Benghalem
authors.forename: Isabelle
authors.initials: I
authors.lastname: Amstutz-Montadert
authors.forename: Yannick
authors.initials: Y
authors.lastname: Lerosey
authors.forename: Eddy
authors.initials: E
authors.lastname: De Vel
authors.forename: Ingeborg
authors.initials: I
authors.lastname: Dhooge
authors.forename: Minka
authors.initials: M
authors.lastname: Hildesheimer
authors.forename: Jona
authors.initials: J
authors.lastname: Kronenberg
authors.forename: Laure
authors.initials: L
authors.lastname: Arnold
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001309:Auditory Threshold; D002648:Child; D019929:Cochlear Implantation / Q000379:methods*; D003054:Cochlear Implants; D015331:Cohort Studies; D003638:Deafness / Q000175:diagnosis / Q000601:surgery; D003952:Diagnostic Imaging / Q000379:methods*; D004558:Electric Stimulation / Q000379:methods; D005072:Evoked Potentials, Auditory; D005260:Female; D006801:Humans; D008144:Loudness Perception; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D015999:Multivariate Analysis; D011182:Postoperative Care / Q000379:methods; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D012022:Reflex, Acoustic / Q000502:physiology*; D012044:Regression Analysis; D012984:Software; D013067:Speech Perception; D013198:Stapedius; D055815:Young Adult