title: Observation of molecular inhibition and binding structures of amyloid peptides.
abstract: Unveiling interactions between labeling molecules and amyloid fibrils is essential to develop new detection methods for studying amyloid structures under various conditions. This review endeavours to reflect the progress in studying interactions between molecular inhibitors and amyloid peptides using a series of experimental approaches, such as X-ray diffraction, nuclear magnetic resonance, scanning probe microscopy, and electron microscopy. The revealed binding mechanisms of anti-amyloid drugs and target proteins could benefit the rational design of drugs for prevention or treatment of amyloidal diseases.
authors.affiliation: National Center for Nanoscience and Technology, Beijing, 100190, PR China.
authors.forename: Chenxuan
authors.initials: C
authors.lastname: Wang
authors.forename: Aihua
authors.initials: A
authors.lastname: Yang
authors.forename: Xia
authors.initials: X
authors.lastname: Li
authors.forename: Denghua
authors.initials: D
authors.lastname: Li
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.forename: Huiwen
authors.initials: H
authors.lastname: Du
authors.forename: Chao
authors.initials: C
authors.lastname: Li
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Guo
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Mao
authors.forename: Mingdong
authors.initials: M
authors.lastname: Dong
authors.forename: Flemming
authors.initials: F
authors.lastname: Besenbacher
authors.forename: Yanlian
authors.initials: Y
authors.lastname: Yang
authors.forename: Chen
authors.initials: C
authors.lastname: Wang
mesh_terms: D058227:Amyloidogenic Proteins / Q000037:antagonists & inhibitors* / Q000737:chemistry*; D001665:Binding Sites; D008956:Models, Chemical; D011485:Protein Binding
chemical_list: D058227:Amyloidogenic Proteins