title: Nuclear PI-PLCβ1 and myelodysplastic syndromes: genetics and epigenetics.
abstract: Among cellular second messengers inositides play key roles in signal transduction pathways. Indeed, nuclear phosphoinositide- specific phospholipase C (PI-PLC) β1 and Akt are involved in cell cycle progression and apoptosis. Nuclear lipid metabolism has raised interest in the last years, mainly because of its link with haematopoietic progenitor cells. Myelodysplastic syndromes (MDS) are stem-cell clonal diseases characterized by an impaired hempoiesis and a differentiation defect in one or more of the bone marrow lineages, often leading to progression to acute myeloid leukaemia (AML). The MDS evolution to AML is not completely understood but, at a molecular level, the nuclear inositide signalling pathways can play an important role in this process.
authors.affiliation: Cellular Signalling Laboratory, Department of Human Anatomical Sciences, University of Bologna, Bologna, Italy.
authors.forename: Matilde Y
authors.initials: MY
authors.lastname: Follo
authors.forename: Sara
authors.initials: S
authors.lastname: Mongiorgi
authors.forename: Carlo
authors.initials: C
authors.lastname: Finelli
authors.forename: Manuela
authors.initials: M
authors.lastname: Piazzi
authors.forename: Irene
authors.initials: I
authors.lastname: Faenza
authors.forename: Giulia
authors.initials: G
authors.lastname: Ramazzotti
authors.forename: Patrizia
authors.initials: P
authors.lastname: Santi
authors.forename: James A
authors.initials: JA
authors.lastname: McCubrey
authors.forename: Alberto M
authors.initials: AM
authors.lastname: Martelli
authors.forename: Lucio
authors.initials: L
authors.lastname: Cocco
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000235:genetics*; D044127:Epigenesis, Genetic / Q000235:genetics*; D006801:Humans; D009190:Myelodysplastic Syndromes / Q000235:genetics*; D054799:Phospholipase C beta / Q000235:genetics*; D015398:Signal Transduction
chemical_list: D054799:Phospholipase C beta