title: Interleukin-17 contributes to cardiovascular diseases.
abstract: Interleukin (IL)-17 (also known as IL-17A), as the signature cytokine of the newly described T helper 17 (Th17) cell population, is the founding member of a new subclass of cytokines that have highly proinflammatory properties. Recently there is accumulating evidence that stipulates the involvement of IL-17 in the pathogenesis of cardiovascular diseases via amplifying the inflammation induced by other cytokines in synergistic interactions. The present review provides a summary of the potential roles of IL-17 in the context derived from both animal models and clinical settings in cardiovascular diseases, and perspectives for IL-17-targeted cytokine therapy.
authors.affiliation: Institute of Cardiovascular Diseases, China Three Gorges University, Yichang, 443000 Hubei Province, China.
authors.forename: Hua-Sheng
authors.initials: HS
authors.lastname: Ding
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.forename: Jian
authors.initials: J
authors.lastname: Yang
authors.forename: Jia-Wang
authors.initials: JW
authors.lastname: Ding
authors.forename: Ping
authors.initials: P
authors.lastname: Chen
authors.forename: Ping
authors.initials: P
authors.lastname: Zhu
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D020381:Interleukin-17 / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D015398:Signal Transduction; D058504:Th17 Cells / Q000276:immunology / Q000378:metabolism
chemical_list: D020381:Interleukin-17