title: On-pump coronary artery bypass graft surgery: biochemical, hormonal and cellular features.
abstract: OBJECTIVE
  The authors sought to assess biochemical, hormonal and cellular repercussions from use of cardiopulmonary bypass (CPB) in coronary artery bypass graft (CABG) surgery.
  
  
  METHODS
  Eighteen patients underwent on-pump CABG surgery. Mean time of CPB was 80.3 minutes. Hormonal, biochemical and cellular measurements were taken in some time points - preoperatively, immediately after coming off CPB, 24 and 48 hours postoperatively. Friedman and Wilcoxon tests were applied based on significance level of 5%.
  
  
  RESULTS
  There was activation and significant elevation of total leukocytes and neutrophils count over CPB, remaining this way up to 48 hours postoperatively. Total platelets count, in turn, was marked by relevant reduction immediately after coming off CPB as well as in two postoperative time points. Serum levels of total proteins and albumin, immediately after coming off CPB and also in two postoperative time points, were significantly decreased comparing with preoperative status. There was remarkable reduction of total T3, free T3 and total T4 particularly up to first 24 hours postoperatively.
  
  
  CONCLUSIONS
  In on-pump CABG surgery, inflammatory effects encompass activation of total leukocytes, neutrophils and platelets, reduction of serum level of total proteins and albumin and decreased thyroid hormones levels, especially within first postoperative 24 hours.
authors.affiliation: Faculdade de Medicina, Universidade de São Paulo, São Paulo, SP, Brasil. edag@uol.com.br
authors.forename: Edmo Atique
authors.initials: EA
authors.lastname: Gabriel
authors.forename: Rafael Fagionato
authors.initials: RF
authors.lastname: Locali
authors.forename: Priscila Katsumi
authors.initials: PK
authors.lastname: Matsuoka
authors.forename: Thiago
authors.initials: T
authors.lastname: Cherbo
authors.forename: Enio
authors.initials: E
authors.lastname: Buffolo
mesh_terms: D001798:Blood Proteins / Q000032:analysis*; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D001026:Coronary Artery Bypass / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D011184:Postoperative Period; D018709:Statistics, Nonparametric; D013963:Thyroid Hormones / Q000097:blood*
chemical_list: D001798:Blood Proteins; D013963:Thyroid Hormones