title: Association between polymorphisms of ERCC1 and survival in epithelial ovarian cancer patients with chemotherapy.
abstract: OBJECTIVE
  We evaluated whether the ERCC1 polymorphisms had an effect on survival in epithelial ovarian cancer (EOC) patients with platinum-based chemotherapy.
  
  
  METHODS
  Clinical data of 209 EOC patients between 2002 and 2008 were reviewed. The genotypes of 19007T/C and 8092C/A polymorphisms were assessed in all patients using PCR-RFLP.
  
  
  RESULTS
  The 19007T/C polymorphism was significantly associated with response to treatment. Compared with the patients carrying C/C genotype, the patients with the T/T genotype have a significantly decreased response to platinum-based chemotherapy (odds ratio: 32.26; 95% CI: 3.66-250.00). Cox's multivariate analysis suggested that EOC patients with the T/T genotype had an increased risk of disease progression (hazard ratio: 3.34; 95% CI: 1.77-6.29) and death (hazard ratio: 2.87; 95% CI: 1.38-5.96) compared with those carrying the C/C genotype.
  
  
  CONCLUSIONS
  The 19007T/C polymorphism may be a useful prognostic marker in patients with EOC treated with platinum-based chemotherapy in Chinese women.
authors.affiliation: Hebei Medical University, Fourth Hospital, Shijiazhuang, 050011, China.
authors.forename: Li
authors.initials: L
authors.lastname: Yan
authors.forename: Yang
authors.initials: Y
authors.lastname: Shu-Ying
authors.forename: Kang
authors.initials: K
authors.lastname: Shan
authors.forename: Benjamin H K
authors.initials: BH
authors.lastname: Yip
authors.forename: Zhou
authors.initials: Z
authors.lastname: Rong-Miao
authors.forename: Wang
authors.initials: W
authors.lastname: Na
authors.forename: Sun
authors.initials: S
authors.lastname: Hai-Yan
mesh_terms: D000328:Adult; D054316:Biomarkers, Pharmacological; D000077216:Carcinoma, Ovarian Epithelial; D002681:China; D004268:DNA-Binding Proteins / Q000235:genetics*; D004720:Endonucleases / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D009375:Neoplasms, Glandular and Epithelial / Q000188:drug therapy / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000235:genetics*; D010984:Platinum / Q000627:therapeutic use*; D011110:Polymorphism, Genetic; D011379:Prognosis; D016019:Survival Analysis
chemical_list: D054316:Biomarkers, Pharmacological; D004268:DNA-Binding Proteins; D010984:Platinum; C071447:ERCC1 protein, human; D004720:Endonucleases