title: [Serum markers of inherited thrombophilia and antiphospholipid antibodies in pregnant women with previous history of severe pre-eclampsia].
abstract: OBJECTIVE
  To determine the frequency and the association of serum markers for inherited and acquired thrombophilias in pregnant women with a history of severe pre-eclampsia in previous pregnancies.
  
  
  METHODS
  Case-control study consisting of 81 pregnant women with a history of severe pre-eclampsia in previous pregnancies (study group) and 32 women with no history of severe pre-eclampsia in previous pregnancies (control group). The presence of inherited thrombophilia and antiphospholipid antibodies was screened in both groups. We used the chi-square test with Yates correction to assess associations and calculate the relative risks.
  
  
  RESULTS
  The presence of thrombophilia was detected in 60.0% of patients with a previous history of pre-eclampsia and in 6.0% of the control patients. A significant association was found between pre-eclampsia in a previous pregnancy and the presence of markers for hereditary thrombophilia/antiphospholipid antibodies (p<0.05). The relative risk to develop pre-eclampsia was found to be 1.57 (1.34<RR<1.84) for pregnant women with antiphospholipid antibodies, 1.53 (1.26<RR<1.86) for women with hereditary thrombophilia markers and 1.86 (1.45<RR<2.38) considering the presence of hereditary thrombophilia and/or antiphospholipid antibodies.
  
  
  CONCLUSIONS
  Women with serum markers for inherited or acquired thrombophilia showed a high relative risk to develop pre-eclampsia.
authors.affiliation: Universidade Federal de Mato Grosso do Sul, Campo Grande, MS, Brasil.
authors.forename: Ernesto Antonio
authors.initials: EA
authors.lastname: Figueiró-Filho
authors.forename: Vanessa Marcon de
authors.initials: VM
authors.lastname: Oliveira
authors.forename: Lílian Rezende
authors.initials: LR
authors.lastname: Coelho
authors.forename: Ili
authors.initials: I
authors.lastname: Breda
mesh_terms: D000328:Adult; D017152:Antibodies, Antiphospholipid / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood*; D011446:Prospective Studies; D012720:Severity of Illness Index; D019851:Thrombophilia / Q000097:blood*
chemical_list: D017152:Antibodies, Antiphospholipid