title: Enhancement of biological activities of nanostructured hydrophobic drug species.
abstract: We report a study of nanoribbons of quercetin, a phase I clinical trial anticancer drug, and their inhibitory effects on cancer cell proliferation. Novel quercetin nanoribbons have been prepared by atmospheric pressure physical vapor deposition (PVD). The nanostructures have been characterized by optical microscopy, scanning electron microscopy, transmission electron microscopy, and Raman spectroscopy, etc. Significantly enhanced solubility in PBS solution and increased drug release rate have been observed for quercetin nanoribbons in comparison to those of quercetin powder. The observed increase of inhibitory effects of quercetin nanoribbons on 4T1 cancel cell growth is correlated with an improvement in their solubility and drug release behavior.
authors.affiliation: CAS Key Lab for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing, 100190, China.
authors.forename: Qiusen
authors.initials: Q
authors.lastname: Han
authors.forename: Rong
authors.initials: R
authors.lastname: Yang
authors.forename: Jingying
authors.initials: J
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Liang
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhang
authors.forename: Mingdong
authors.initials: M
authors.lastname: Dong
authors.forename: Flemming
authors.initials: F
authors.lastname: Besenbacher
authors.forename: Chen
authors.initials: C
authors.lastname: Wang
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects*; D004339:Drug Compounding / Q000379:methods*; D004357:Drug Synergism; D057927:Hydrophobic and Hydrophilic Interactions; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use* / Q000648:ultrastructure; D011794:Quercetin / Q000138:chemical synthesis* / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D011794:Quercetin