title: The association between availability of serotonin transporters and time to relapse in heroin users: a two-isotope SPECT small sample pilot study.
abstract: Neuroimaging evidence supporting an association between either dopamine or serotonin and time to relapse of heroin users is limited. In this two-isotope SPECT small sample (N=9) pilot study, the relationship between the availability of serotonin transporter (SERT) and dopamine transporter (DAT) and the relapse of heroin users was investigated. A significant negative association between SERT availability and time to relapse among those who relapsed (N=7) was found.
authors.affiliation: Department of Psychiatry, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
authors.forename: Shih-Hsien
authors.initials: SH
authors.lastname: Lin
authors.forename: Kao Chin
authors.initials: KC
authors.lastname: Chen
authors.forename: Sheng-Yu
authors.initials: SY
authors.lastname: Lee
authors.forename: Wei Jen
authors.initials: WJ
authors.lastname: Yao
authors.forename: Nan-Tsing
authors.initials: NT
authors.lastname: Chiu
authors.forename: I Hui
authors.initials: IH
authors.lastname: Lee
authors.forename: Po See
authors.initials: PS
authors.lastname: Chen
authors.forename: Tzung Lieh
authors.initials: TL
authors.lastname: Yeh
authors.forename: Mei-Hsiu
authors.initials: MH
authors.lastname: Liao
authors.forename: Ru-Band
authors.initials: RB
authors.lastname: Lu
authors.forename: Yen Kuang
authors.initials: YK
authors.lastname: Yang
mesh_terms: D000328:Adult; D002928:Cinanserin / Q000031:analogs & derivatives; D003342:Corpus Striatum / Q000378:metabolism; D050483:Dopamine Plasma Membrane Transport Proteins / Q000378:metabolism; D005260:Female; D059907:Functional Neuroimaging / Q000379:methods / Q000523:psychology* / Q000706:statistics & numerical data; D006556:Heroin Dependence / Q000378:metabolism*; D006801:Humans; D008297:Male; D008636:Mesencephalon / Q000378:metabolism; D015609:Organotechnetium Compounds; D010865:Pilot Projects; D019275:Radiopharmaceuticals; D012008:Recurrence; D050486:Serotonin Plasma Membrane Transport Proteins / Q000378:metabolism*; D013997:Time Factors; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods / Q000523:psychology / Q000706:statistics & numerical data; D014326:Tropanes
chemical_list: C413491:2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine; D050483:Dopamine Plasma Membrane Transport Proteins; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D050486:Serotonin Plasma Membrane Transport Proteins; D014326:Tropanes; C104196:technetium Tc 99m TRODAT-1; D002928:Cinanserin