title: Repeated microinjections into the medial prefrontal cortex (mPFC) impair extinction of conditioned place preference in mice.
abstract: The medial prefrontal cortex (mPFC) is important for extinction of many behaviors including conditioned place preference (CPP). We examined the effects of intra-mPFC inactivation (with bupivacaine) on extinction of ethanol-induced CPP in mice. Injections of both bupivacaine and vehicle impaired extinction whereas no-surgery control mice extinguished normally. Consistent with recently reported effects of mPFC lesions, these data suggest that extinction was impaired by excessive mPFC damage induced by repeated intracranial infusions.
authors.affiliation: Dept. of Behavioral Neuroscience and Portland Alcohol Research Center, Oregon Health & Science University, Portland, OR 97239, United States.
authors.forename: Peter A
authors.initials: PA
authors.lastname: Groblewski
authors.forename: Christopher L
authors.initials: CL
authors.lastname: Cunningham
mesh_terms: D000704:Analysis of Variance; D000779:Anesthetics, Local / Q000009:adverse effects; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D002045:Bupivacaine / Q000009:adverse effects; D002492:Central Nervous System Depressants / Q000009:adverse effects; D003216:Conditioning, Operant / Q000187:drug effects / Q000502:physiology*; D004195:Disease Models, Animal; D000431:Ethanol / Q000009:adverse effects; D005108:Extinction, Psychological / Q000187:drug effects / Q000502:physiology*; D007859:Learning Disabilities / Q000139:chemically induced / Q000188:drug therapy / Q000503:physiopathology*; D008297:Male; D000077239:Meloxicam; D051379:Mice; D008811:Mice, Inbred DBA; D008845:Microinjections / Q000009:adverse effects; D017397:Prefrontal Cortex / Q000187:drug effects / Q000502:physiology*; D013843:Thiazines / Q000008:administration & dosage; D013844:Thiazoles / Q000008:administration & dosage; D013997:Time Factors
chemical_list: D000779:Anesthetics, Local; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002492:Central Nervous System Depressants; D013843:Thiazines; D013844:Thiazoles; D000431:Ethanol; D000077239:Meloxicam; D002045:Bupivacaine