title: A comparison of pain-related behavior following local application of nucleus pulposus and/or mechanical compression on the dorsal root ganglion.
abstract: Symptomatic induction of disc herniation involves both mechanical compression and chemical factors. Inhibitors of tumor necrosis factor-alpha (TNF-α) are known to reduce pain-related behavior in experimental models. Animals were divided into mechanical compression (MC) group; a stainless steel rod was inserted on the dorsal root ganglion, nucleus pulposus (NP) group: NP was harvested from the coccygeal vertebral disc, MC and NP group; rats were received stainless rod and NP, and sham group; rats were received neither rod nor NP. Rats in the MC group received a TNF-α antibody (10 mg/kg) (antibody group) or were not treatment (untreated group). The withdrawal thresholds of the MC, NP and MC+NP groups decreased significantly compared with the sham group. In the antibody group, the threshold was significantly higher than that of the untreated group. An anti-TNF-α antibody reduced allodynia caused by DRG compression.
authors.affiliation: Department of Orthopedic Surgery, School of Medicine, Fukushima Medical University, Fukushima, Japan.
authors.forename: Nobuhisa
authors.initials: N
authors.lastname: Sasaki
authors.forename: Miho
authors.initials: M
authors.lastname: Sekiguchi
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Shishido
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Kikuchi
authors.forename: Shoji
authors.initials: S
authors.lastname: Yabuki
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Konno
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D004195:Disease Models, Animal; D005727:Ganglia, Spinal / Q000502:physiology*; D007405:Intervertebral Disc Displacement / Q000188:drug therapy*; D008297:Male; D010146:Pain / Q000188:drug therapy* / Q000523:psychology; D017288:Pain Threshold; D051381:Rats; D017207:Rats, Sprague-Dawley; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
chemical_list: D014409:Tumor Necrosis Factor-alpha