title: Effects of breviscapine on pulmonary inflammatory response and lung injury in children undergoing open heart surgery.
abstract: This study examined the effects of breviscapine (1) on pulmonary inflammatory response and lung function in pediatric patients undergoing open heart surgery. Forty-five children (ASA II or III, aged 2-72 months) were randomly assigned to control group (saline, Group C), low dose 1 group (0.5 mg/kg, Group Bre0.5), and high dose 1 group (1.0 mg/kg, Group Bre1.0), 15 cases each group. Plasma concentrations of procalcitonin (PCT) and neutrophil elastase (NE) were measured and compared at different time points. Plasma concentrations of PCT and NE were increased after cardiopulmonary bypass (CPB) induction, and the concentrations were lower in 1-treated groups. The present results indicated that continuous infusion of 1 before the CPB suppressed the production of PCT and NE attenuated systemic inflammatory response, which could result in lung protective effect in children undergoing open heart surgery.
authors.affiliation: Department of Anaesthesiology, The 2nd Affiliated Hospital of Wenzhou Medical College, Wenzhou, 325027, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Chen
authors.forename: Ying-Hua
authors.initials: YH
authors.lastname: Zhao
authors.forename: Xiu-Lan
authors.initials: XL
authors.lastname: Liu
authors.forename: Xiao-Ling
authors.initials: XL
authors.lastname: Chen
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Qing-Quan
authors.initials: QQ
authors.lastname: Lian
authors.forename: Yun
authors.initials: Y
authors.lastname: Xia
authors.forename: Wang-Ning
authors.initials: WN
authors.lastname: Shangguan
mesh_terms: D000293:Adolescent; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000737:chemistry; D002116:Calcitonin / Q000032:analysis / Q000097:blood; D015740:Calcitonin Gene-Related Peptide; D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass / Q000379:methods; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D007223:Infant; D019272:Leukocyte Elastase / Q000032:analysis / Q000097:blood; D011498:Protein Precursors / Q000032:analysis / Q000097:blood; D013903:Thoracic Surgery
chemical_list: D000893:Anti-Inflammatory Agents; C000606589:CALCA protein, human; D005419:Flavonoids; D011498:Protein Precursors; C061097:breviscapine; D002116:Calcitonin; D019272:Leukocyte Elastase; D015740:Calcitonin Gene-Related Peptide