title: Advances in proline ligation.
abstract: Application of native chemical ligation logic to the case of an N-terminal proline is described. Two approaches were studied. One involved incorporation of a 3R-substituted thiyl-proline derivative. Improved results were obtained from a 3R-substituted selenol function, incorporated in the context of an oxidized dimer.
authors.affiliation: Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10065, USA.
authors.forename: Steven D
authors.initials: SD
authors.lastname: Townsend
authors.forename: Zhongping
authors.initials: Z
authors.lastname: Tan
authors.forename: Suwei
authors.initials: S
authors.lastname: Dong
authors.forename: Shiying
authors.initials: S
authors.lastname: Shang
authors.forename: John A
authors.initials: JA
authors.lastname: Brailsford
authors.forename: Samuel J
authors.initials: SJ
authors.lastname: Danishefsky
mesh_terms: D004921:Erythropoietin / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D011392:Proline / Q000031:analogs & derivatives / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D004921:Erythropoietin; D011392:Proline