title: Targeting tuberculosis: a glimpse of promising drug targets.
abstract: Tuberculosis caused by Mycobacterium tuberculosis has emerged as the biggest curse of our time causing significant morbidity and mortality. Increasing resistance in mycobacterium to existing drugs calls for exploration of metabolic pathways for finding novel drug targets and also for prioritization of known drug targets. Recent advances in molecular biology, bioinformatics and structural biology coupled with availability of M. tuberculosis genome sequence have provided much needed boost to drug discovery process. This review provides a glimpse of attractive drug targets for development of anti-mycobacterial drug development.
authors.affiliation: Centre for Cellular and Molecular Biology (CSIR), Uppal Road, Hyderabad 500007 (AP), India. neelimaiict@gmail.com
authors.forename: N
authors.initials: N
authors.lastname: Arora
authors.forename: A K
authors.initials: AK
authors.lastname: Banerjee
mesh_terms: D000818:Animals; D000995:Antitubercular Agents / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D055808:Drug Discovery / Q000379:methods; D015964:Gene Expression Regulation, Bacterial / Q000187:drug effects; D016680:Genome, Bacterial / Q000187:drug effects; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects; D014376:Tuberculosis / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents