title: Schizosaccharomyces pombe homologs of the Saccharomyces cerevisiae mitochondrial proteins Cbp6 and Mss51 function at a post-translational step of respiratory complex biogenesis.
abstract: Complexes III and IV of the mitochondrial respiratory chain contain a few key subunits encoded by the mitochondrial genome. In Saccharomyces cerevisiae, fifteen mRNA-specific translational activators control mitochondrial translation, of which five are conserved in Schizosaccharomyces pombe. These include homologs of Cbp3, Cbp6 and Mss51 that participate in translation and the post-translational steps leading to the assembly of respiratory complexes III and IV. In this study we show that in contrast to budding yeast, Cbp3, Cbp6 and Mss51 from S. pombe are not required for the translation of mitochondrial mRNAs, but fulfill post-translational functions, thus probably accounting for their conservation.
authors.affiliation: Centre de Génétique Moléculaire du CNRS, UPR 3404, FRC3115, Avenue de la Terrasse, 91198 Gif-sur-Yvette Cedex, France.
authors.forename: Inge
authors.initials: I
authors.lastname: Kühl
authors.forename: Thomas D
authors.initials: TD
authors.lastname: Fox
authors.forename: Nathalie
authors.initials: N
authors.lastname: Bonnefoy
mesh_terms: D000595:Amino Acid Sequence; D003576:Electron Transport Complex IV / Q000096:biosynthesis* / Q000235:genetics; D005656:Fungal Proteins / Q000235:genetics / Q000378:metabolism; D015966:Gene Expression Regulation, Fungal; D008928:Mitochondria / Q000235:genetics / Q000378:metabolism; D024101:Mitochondrial Proteins / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D001678:Organelle Biogenesis; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D000077278:RNA, Mitochondrial; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism; D012568:Schizosaccharomyces / Q000235:genetics / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: C561113:Cbp6 protein, S cerevisiae; D005656:Fungal Proteins; D024101:Mitochondrial Proteins; C519191:Mss51 protein, S cerevisiae; D012333:RNA, Messenger; D000077278:RNA, Mitochondrial; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; C029305:mitochondrial messenger RNA; D003576:Electron Transport Complex IV