title: Comparison of personality characteristics in Parkinson disease patients with and without impulse control disorders and in healthy volunteers.
abstract: OBJECTIVE
  We aimed to assess personality characteristics in patients with Parkinson disease (PD) with and without impulse control disorders (ICD).
  
  
  METHODS
  We tested patients and controls with the Minnesota Multiphasic Personality Inventory-2 (MMPI-2) scales that have expected high sensitivity to apparent addictive behavior. We recorded mean disease duration and mean levodopa dose in the PD groups.
  
  
  RESULTS
  Of the 46 PD patients, 13 had ICD: hypersexuality, binge eating, or dopamine dysregulation. The PD patients with ICD had a longer duration of disease (11 vs. 5 y) and were taking higher doses of levodopa (900 vs. 500 mg/d). They scored above the pathologic threshold in 4 domains of the MMPI-2 Clinical Scales and in 8 Clinical Subscales and Content Scales. The most significant abnormality was Alienation-Self and Others.
  
  
  CONCLUSIONS
  ICDs in the general population have similarities to disorders of substance addiction. In PD patients, some personality profiles could play a role in development of ICDs or dopamine dysregulation syndrome. The MMPI-2 may be a useful test for PD patients in general, and for detecting ICD in particular.
authors.affiliation: Department of Neurology, Palacky University Medical School, University Hospital, Olomouc, Czech Republic. katmen@centrum.cz
authors.forename: Katerina
authors.initials: K
authors.lastname: Farnikova
authors.forename: Radko
authors.initials: R
authors.lastname: Obereigneru
authors.forename: Petr
authors.initials: P
authors.lastname: Kanovsky
authors.forename: Jan
authors.initials: J
authors.lastname: Prasko
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D007174:Disruptive, Impulse Control, and Conduct Disorders / Q000150:complications / Q000523:psychology*; D005260:Female; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D008950:MMPI / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications / Q000188:drug therapy / Q000523:psychology*; D013997:Time Factors
chemical_list: D007980:Levodopa