title: 2,5-diketopiperazines from the marine-derived fungus Aspergillus fumigatus YK-7.
abstract: Five new diketopiperazines, prenylcyclotryprostatin B (1), 20-hydroxycyclotryprostatin B (2), 9-hydroxyfumitremorgin C (3), 6-hydroxytryprostatin B (4), and spirogliotoxin (5), were isolated from the marine-derived fungus Aspergillus fumigatus YK-7, along with nine known compounds, 6-14. Their structures were elucidated by spectroscopic methods, and their antiproliferative effects on human leukemic monocyte lymphoma U937 and human prostate cancer PC-3 cell lines were assessed in vitro. Compounds 10, 12, and 13 exhibited significant cell growth-inhibitory activities against U937 cell line, with the IC(50) values of 1.8, 0.2, and 0.5 μM, respectively.
authors.affiliation: Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.forename: Zhan-Lin
authors.initials: ZL
authors.lastname: Li
authors.forename: Jiao
authors.initials: J
authors.lastname: Bai
authors.forename: Li-Min
authors.initials: LM
authors.lastname: Zhang
authors.forename: Xin
authors.initials: X
authors.lastname: Wu
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
authors.forename: Yue-Hu
authors.initials: YH
authors.lastname: Pei
authors.forename: Yong-Kui
authors.initials: YK
authors.lastname: Jing
authors.forename: Hui-Ming
authors.initials: HM
authors.lastname: Hua
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001232:Aspergillus fumigatus / Q000737:chemistry*; D054659:Diketopiperazines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008386:Marine Biology; D015394:Molecular Structure; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D020298:U937 Cells / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D054659:Diketopiperazines