title: Perchlorate, iodine supplements, iodized salt and breast milk iodine content.
abstract: This study was undertaken to determine if increasing maternal iodine intake through single dose tablets will decrease breast milk concentrations of the iodine-uptake inhibitor, perchlorate, through competitive inhibition. We also sought to determine if the timing of supplementation influences the fraction of iodine excreted in milk versus urine and to compare the effectiveness of iodized salt as a means of providing iodine to breastfed infants. Thirteen women who did not use supplements, seven of whom used iodized salt and six of whom used non-iodized salt, submitted four milk samples and a 24-h urine collection daily for three days. Women repeated the sampling protocol for three more days during which ~150μg of iodine were taken in the evening and again for three days with morning supplementation. Samples were analyzed using isotope-dilution inductively-coupled plasma-mass spectrometry for iodine and isotope-dilution ion chromatography-tandem mass spectrometry for perchlorate. No statistically significant differences were observed in milk iodine or perchlorate concentrations during the two treatment periods. Estimated perchlorate intake was above the U.S. National Academy of Sciences suggested reference dose for most infants. Single daily dose iodine supplementation was not effective in decreasing milk perchlorate concentrations. Users of iodized salt had significantly higher iodine levels in milk than non-users. Iodized salt may be a more effective means of iodine supplementation than tablets.
authors.affiliation: Department of Epidemiology, School of Public Health, University of North Texas Health Sciences Center, 3500 Camp Bowie Blvd., Fort Worth, TX 76107, USA.
authors.forename: Andrea B
authors.initials: AB
authors.lastname: Kirk
authors.forename: Martina
authors.initials: M
authors.lastname: Kroll
authors.forename: Jason V
authors.initials: JV
authors.lastname: Dyke
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Ohira
authors.forename: Rukshan A
authors.initials: RA
authors.lastname: Dias
authors.forename: Purnendu K
authors.initials: PK
authors.lastname: Dasgupta
mesh_terms: D000328:Adult; D001667:Binding, Competitive; D015331:Cohort Studies; D003404:Creatinine / Q000652:urine; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D007223:Infant; D007455:Iodine / Q000378:metabolism / Q000494:pharmacology* / Q000652:urine; D008297:Male; D008895:Milk, Human / Q000737:chemistry / Q000378:metabolism*; D010472:Perchlorates / Q000737:chemistry / Q000378:metabolism* / Q000652:urine; D017673:Sodium Chloride, Dietary / Q000378:metabolism*
chemical_list: D010472:Perchlorates; D017673:Sodium Chloride, Dietary; C034024:iodized salt; D007455:Iodine; D003404:Creatinine; C494474:perchlorate