title: The features of radiation induced lung fibrosis related with dosimetric parameters.
abstract: OBJECTIVE
  Radiation induced lung fibrosis (RILF) is a major complication after lung irradiation and is very important for long term quality of life and could result in fatal respiratory insufficiency. However, there has been little information on dosimetric parameters for radiotherapy planning in the aspect of RILF. The features of RILF related with dosimetric parameters were evaluated.
  
  
  METHODS
  Forty-eight patients with non-small cell lung carcinoma who underwent post-operative radiation therapy (PORT) without adjuvant chemotherapy were analyzed. The degree of lung fibrosis was estimated by fibrosis volume and the dosimetric parameters were calculated from the plan of 3-dimensional conformal radiotherapy.
  
  
  RESULTS
  The fibrosis volume and V-dose as dosimetric parameters showed significant correlation and the correlation coefficient ranged from 0.602 to 0.683 (P<0.01). The degree of the correlation line was steeper as the dose increase and threshold dose was not found. Mean lung dose (MLD) showed strong correlation with fibrosis volume (correlation coefficient = 0.726, P<0.01).
  
  
  CONCLUSIONS
  The fibrosis volume is continuously increased with V-dose as the reference dose increases. MLD is useful as a single parameter for comparing rival plans in the aspect of RILF.
authors.affiliation: Department of Radiation Oncology, Ajou University School of Medicine, Suwon, Republic of Korea.
authors.forename: Young-Taek
authors.initials: YT
authors.lastname: Oh
authors.forename: O Kyu
authors.initials: OK
authors.lastname: Noh
authors.forename: Hyunsoo
authors.initials: H
authors.lastname: Jang
authors.forename: Mison
authors.initials: M
authors.lastname: Chun
authors.forename: Kyung Joo
authors.initials: KJ
authors.lastname: Park
authors.forename: Kwang Joo
authors.initials: KJ
authors.lastname: Park
authors.forename: Mi-Hwa
authors.initials: MH
authors.lastname: Kim
authors.forename: Hae-Jin
authors.initials: HJ
authors.lastname: Park
mesh_terms: D000328:Adult; D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D011658:Pulmonary Fibrosis / Q000209:etiology* / Q000473:pathology; D011832:Radiation Injuries / Q000209:etiology* / Q000473:pathology; D011879:Radiotherapy Dosage