title: Advances in structural modifications and biological activities of berberine: an active compound in traditional Chinese medicine.
abstract: Berberine is an isoquinoline alkaloid isolated from Chinese herbs such as Coptidis Rhizome. This paper is a systematic review of the structural modifications of berberine for different biological activities such as antitumor, antimicrobial, anti-Alzheimer's disease, antihyperglycemic, anti-inflammatory and antimalaria. The current review would provide some useful information for further studies on structural modification of berberine for discovering new drug leads.
authors.affiliation: Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, College of Pharmacy, Jinan University, Guangzhou, P. R. China.
authors.forename: Z-J
authors.initials: ZJ
authors.lastname: Huang
authors.forename: Y
authors.initials: Y
authors.lastname: Zeng
authors.forename: P
authors.initials: P
authors.lastname: Lan
authors.forename: P-H
authors.initials: PH
authors.lastname: Sun
authors.forename: W-M
authors.initials: WM
authors.lastname: Chen
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy; D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D001424:Bacterial Infections / Q000188:drug therapy; D001599:Berberine / Q000737:chemistry* / Q000494:pharmacology*; D000089042:Coptis chinensis; D003920:Diabetes Mellitus / Q000188:drug therapy; D055808:Drug Discovery / Q000379:methods; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology; D008288:Malaria / Q000188:drug therapy; D008516:Medicine, Chinese Traditional; D009181:Mycoses / Q000188:drug therapy; D009369:Neoplasms / Q000188:drug therapy
chemical_list: D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D000962:Antimalarials; D000970:Antineoplastic Agents; D004365:Drugs, Chinese Herbal; D007004:Hypoglycemic Agents; D001599:Berberine; C107393:Coptidis rhizoma extract