title: Increased levels of IL-23 and osteopontin in serum and cerebrospinal fluid of multiple sclerosis patients.
abstract: Osteopontin (OPN) and interleukin-23 (IL-23) are pro-inflammatory cytokines proposed to play central roles to the development of multiple sclerosis (MS). The aim of this study was to evaluate levels of OPN, IL-23 and other inflammatory cytokines and investigate their relationships in serum and cerebrospinal fluid (CSF) in patients with MS. Fifty one MS patients and 48 patients with non-inflammatory neurological diseases (NIND) were recruited from clinic. The levels of OPN, IL-23, IL-17, IL-6, and tumor necrosis factor-alpha (TNF-alpha) in serum and CSF were determined in each participant. Compared with NIND group, MS patients had significantly elevated levels of OPN, IL-23, IL-17 and TNF-alpha in CSF, and elevated levels of IL-23, IL-17 and TNF-alpha in serum (All P<0.001). In MS patients, OPN and IL-23 were positively correlated with IL-17 (r=0.302, P=0.019; r=0.417, P=0.001, respectively); and IL-23 was positively correlated with EDSS (r=0.329, P=0.019). Both OPN and IL-23 may play pivotal role in development of MS and might be specific markers and therapeutic targets for MS.
authors.affiliation: Department of Neurology, The First Affiliated Hospital, Harbin Medical University, Harbin, PR China.
authors.forename: Shi-Rong
authors.initials: SR
authors.lastname: Wen
authors.forename: Guo-Jun
authors.initials: GJ
authors.lastname: Liu
authors.forename: Ren-Nan
authors.initials: RN
authors.lastname: Feng
authors.forename: Feng-Chao
authors.initials: FC
authors.lastname: Gong
authors.forename: Hua
authors.initials: H
authors.lastname: Zhong
authors.forename: Shu-Rong
authors.initials: SR
authors.lastname: Duan
authors.forename: Sheng
authors.initials: S
authors.lastname: Bi
mesh_terms: D000328:Adult; D016207:Cytokines / Q000097:blood / Q000134:cerebrospinal fluid; D005260:Female; D006801:Humans; D053583:Interleukin-1beta / Q000097:blood; D053759:Interleukin-23 / Q000097:blood* / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood* / Q000134:cerebrospinal fluid*; D009422:Nervous System Diseases / Q000097:blood / Q000134:cerebrospinal fluid; D053495:Osteopontin / Q000097:blood* / Q000134:cerebrospinal fluid*; D055815:Young Adult
chemical_list: D016207:Cytokines; D053583:Interleukin-1beta; D053759:Interleukin-23; D053495:Osteopontin