title: [The increase of bioavailability and anti-inflammatory effect of indomethacin loaded into phospholipid nanoparticles].
abstract: The ultrafine formulation on the base of plant phosphatidylcholine and antiinflammatory remedy indomethacin with nanoparticles less than 50 nm was obtained. Drug bioavailability after its peroral administration to rats was more than 2 fold higher as compared with free indomethacin. Increased antiinflammatory activity of indomethacin in phospholipids nanoparticles as compared with its free form was shown in two models of inflammation - adjuvant arthritis in rats and conconavalin A induced edema in mice. The increased bioavailability of indomethacin after administration of its phospholipid formulation allows to decrease a dose for achievement of therapeutic effect, that reduces risks of occurrence of collateral displays.
authors.forename: A V
authors.initials: AV
authors.lastname: Shironin
authors.forename: O M
authors.initials: OM
authors.lastname: Ipatova
authors.forename: N V
authors.initials: NV
authors.lastname: Medvedeva
authors.forename: V N
authors.initials: VN
authors.lastname: Prozorovskiĭ
authors.forename: E G
authors.initials: EG
authors.lastname: Tikhonova
authors.forename: T S
authors.initials: TS
authors.lastname: Zakharova
authors.forename: M A
authors.initials: MA
authors.lastname: Sanzhakov
authors.forename: T I
authors.initials: TI
authors.lastname: Torkhovskaia
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000097:blood* / Q000276:immunology / Q000627:therapeutic use; D001169:Arthritis, Experimental / Q000188:drug therapy; D001682:Biological Availability; D004195:Disease Models, Animal; D004337:Drug Carriers / Q000737:chemistry*; D007213:Indomethacin / Q000008:administration & dosage* / Q000097:blood* / Q000276:immunology / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D053758:Nanoparticles; D010316:Particle Size; D010743:Phospholipids / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D010743:Phospholipids; D007213:Indomethacin