title: Lysine-specific histone demethylase 1 (LSD1): A potential molecular target for tumor therapy.
abstract: Lysine-specific demethylase 1 (LSD1), the first identified histone demethylase, was belonged to the superfamily of the flavin adenine dinucleotide (FAD)-dependent amine oxidases. LSD1 specifically demethylates mono- or dimethylated dimethylated histone H3 lysine4 (H3K4) and H3 lysine 9 (H3K9) via a redox process. Recently evidences showed that LSD1 played an important role in a broad spectrum of biological processes, including cell proliferation, adipogenesis, spermatogenesis, chromosome segregation and embryonic development. Furthermore, LSD1 also could promote progress of tumor by inhibiting the tumor suppressor activity of p53. To date, as a potential drug for discovering anti-tumor drugs, the medical significance of LSD1 inhibitors have been greatly appreciated. Here, we reviewed the remarkable progress being made in understanding of LSD1, mainly on its structure, basic function and medical application in tumor therapy.
authors.affiliation: Department of Gastroenterology, Shanghai Jiao Tong University, School of Medicine, Xin Hua Hospital, Shanghai, China.
authors.forename: Yingwei
authors.initials: Y
authors.lastname: Chen
authors.forename: Wen
authors.initials: W
authors.lastname: Jie
authors.forename: Weihui
authors.initials: W
authors.lastname: Yan
authors.forename: Kejun
authors.initials: K
authors.lastname: Zhou
authors.forename: Yongtao
authors.initials: Y
authors.lastname: Xiao
mesh_terms: D050156:Adipogenesis; D000818:Animals; D049109:Cell Proliferation; D020090:Chromosome Segregation; D055808:Drug Discovery; D050687:E2F1 Transcription Factor / Q000378:metabolism; D053595:Embryonic Stem Cells / Q000378:metabolism; D058750:Epithelial-Mesenchymal Transition / Q000502:physiology; D005182:Flavin-Adenine Dinucleotide / Q000378:metabolism; D056466:Histone Demethylases / Q000037:antagonists & inhibitors / Q000737:chemistry* / Q000378:metabolism*; D006657:Histones / Q000378:metabolism; D006801:Humans; D051379:Mice; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy* / Q000201:enzymology*; D010766:Phosphorylation; D016160:Retinoblastoma Protein / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D050687:E2F1 Transcription Factor; C493753:E2F1 protein, human; D006657:Histones; D016160:Retinoblastoma Protein; D016159:Tumor Suppressor Protein p53; D005182:Flavin-Adenine Dinucleotide; D056466:Histone Demethylases; C495195:KDM1A protein, human