title: [The initial observation of adenovirus vector-mediated herpes simplex virus-thymidine kinase gene/ganciclovir system and photodynamic therapy for oral malignant tumor treatments].
abstract: OBJECTIVE
  To evaluate the method of adenovirus vector-mediated herpes simplex virus-thymidine kinase gene (ADV-TK)/ganciclovir(GCV) system and photodynamic therapy(PDT) for treating the oral malignant tumor.
  
  
  METHODS
  Ten patients who were suffering from oral malignant tumor of the different positions were selected, and injected with the hematoporphyrin derivative (HPD), irradiated by picking the corresponding laser frequency, and injected the ADV-TK gene into the tumor body and periphery. By the imaging and the hemodynamics analysis, the clinical efficacy after infusing vein with GCV was assessed.
  
  
  RESULTS
  After the combination method treatments, patients' tumors appeared clear shrinkage or complete extinction. There was obvious fall of the blood flow volume in the tumor body. Imaging results showed significantly differences. So it was a perfect and effective treatment.
  
  
  CONCLUSIONS
  There are many advantages to apply the ADV-TK/GCV system and PDT treatment on the oral malignant tumor, minimal side effects and greater clinical security. It is a safe and credible therapy which can be offered for curing the oral malignant tumor systematically.
authors.affiliation: Dept. of Stomatology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
authors.forename: Shizhang
authors.initials: S
authors.lastname: Chen
authors.forename: Yansheng
authors.initials: Y
authors.lastname: Zhang
authors.forename: Zhong
authors.initials: Z
authors.lastname: Fan
authors.forename: Weidi
authors.initials: W
authors.lastname: Li
authors.forename: Ying
authors.initials: Y
authors.lastname: Guo
authors.forename: Xiao
authors.initials: X
authors.lastname: Wang
authors.forename: Jianfei
authors.initials: J
authors.lastname: Chen
authors.forename: Ning
authors.initials: N
authors.lastname: Li
mesh_terms: D000256:Adenoviridae; D015774:Ganciclovir; D005822:Genetic Vectors; D006801:Humans; D009369:Neoplasms; D010778:Photochemotherapy; D018139:Simplexvirus; D013937:Thymidine Kinase
chemical_list: D013937:Thymidine Kinase; D015774:Ganciclovir