title: Comparison of various lipid variables as predictors of coronary heart disease in Japanese men and women with type 2 diabetes: subanalysis of the Japan Diabetes Complications Study.
abstract: OBJECTIVE
  To determine the best lipid variable to predict coronary heart disease (CHD) in Japanese patients with type 2 diabetes.
  
  
  METHODS
  Eligible Japanese men and women (1,771) aged 40-70 years with type 2 diabetes from 59 institutes nationwide were followed for a planned 8-year period. The performance of eight conventional lipid variables, i.e., total cholesterol (TC), LDL-cholesterol (LDLC), HDL-cholesterol (HDLC), triglycerides (TGs), non-HDLC, TC/HDLC ratio, LDLC/HDLC ratio, and TG/HDLC ratio, as predictors of incident CHD were evaluated by four methods: hazard ratio (HR) per one SD increment by multivariate Cox analysis, χ(2) likelihood ratio test, area under the receiver operating characteristic curve (AUC), and tertile analysis.
  
  
  RESULTS
  Although all variables significantly predicted CHD events in men, non-HDLC (HR per one SD 1.78 [95% CI 1.43-2.21]; AUC 0.726) and TC/HDLC (HR 1.63 [1.36-1.95]; AUC 0.718) had the better predictive performances among the variables, including LDLC. In women, TGs (log-transformed; HR 1.72 [1.21-2.43]; AUC 0.708) were the best predictor according to results of tertile analysis (HR of the top tertile versus the bottom tertile 4.31 [1.53-12.16]). The associations with incident CHD were linear and continuous.
  
  
  CONCLUSIONS
  For Japanese diabetic men, non-HDLC and TC/HDLC were the best predictors, whereas TGs were most predictive for women. These findings, which included prominent sex differences, should be considered among clinical approaches to risk reduction among East Asians with diabetes.
authors.affiliation: Department of Internal Medicine, Institute of Clinical Medicine,University of Tsukuba, Tsukuba, Japan. jdcstudy@md.tsukuba.ac.jp
authors.forename: Hirohito
authors.initials: H
authors.lastname: Sone
authors.forename: Sachiko
authors.initials: S
authors.lastname: Tanaka
authors.forename: Shiro
authors.initials: S
authors.lastname: Tanaka
authors.forename: Satoshi
authors.initials: S
authors.lastname: Iimuro
authors.forename: Shun
authors.initials: S
authors.lastname: Ishibashi
authors.forename: Shinichi
authors.initials: S
authors.lastname: Oikawa
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Shimano
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Katayama
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Ohashi
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Akanuma
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Yamada
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003324:Coronary Artery Disease / Q000097:blood / Q000209:etiology* / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications* / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D002784:Cholesterol