title: Pseudocystic dermatofibrosarcoma protuberans: report of two cases and demonstration of COL1A1-PDGFB rearrangement.
abstract: We report two unique cases of dermatofibrosarcoma protuberans (DFSP) that included a pseudocystic component. Molecular analysis of one of the cases showed a characteristic COL1A1-PDGFB rearrangement in both the main tumor and also in the cells lining the pseudocystic portion of the tumor, confirming the diagnosis and indicating that the lining represented a component of the proliferation. It is important to raise awareness of this rare variant within the varied spectrum of DFSP. Shvartsbeyn M, Lazar AJF, Lopez-Terrada D, Meehan SA. Pseudocystic dermatofibrosarcoma protuberans: report of two cases and demonstration of COL1A1-PDGFB rearrangement.
authors.affiliation: Department of Pathology, New York University, New York, NY 10016, USA. Marianna.Shvartsbeyn@nyumc.org
authors.forename: Marianna
authors.initials: M
authors.lastname: Shvartsbeyn
authors.forename: Alexander J F
authors.initials: AJ
authors.lastname: Lazar
authors.forename: Dolores
authors.initials: D
authors.lastname: Lopez-Terrada
authors.forename: Shane A
authors.initials: SA
authors.lastname: Meehan
mesh_terms: D000328:Adult; D049109:Cell Proliferation; D024042:Collagen Type I / Q000235:genetics*; D000090602:Collagen Type I, alpha 1 Chain; D003560:Cysts / Q000235:genetics / Q000473:pathology; D018223:Dermatofibrosarcoma / Q000235:genetics / Q000473:pathology; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D008297:Male; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D020574:Proto-Oncogene Proteins c-sis / Q000235:genetics*; D012878:Skin Neoplasms / Q000235:genetics / Q000473:pathology
chemical_list: D024042:Collagen Type I; D000090602:Collagen Type I, alpha 1 Chain; D015514:Oncogene Proteins, Fusion; D020574:Proto-Oncogene Proteins c-sis