title: Anxiety-depressive disorders among irritable bowel syndrome patients in Guilan, Iran.
abstract: BACKGROUND
  Psychiatric disorders are common in irritable bowel syndrome (IBS) patients. The prevalence of psychiatric disorders in IBS patients varies in different cultures. We conducted this study to determine the prevalence of psychiatric disorders
  
  
  METHODS
  In a cross-sectional study, 256 IBS patients were selected (using the criteria of Rome III) and evaluated for psychiatric disorders. In the first phase, subjects were screened using the General Health Questionnaire 28 (GHQ28). In the second phase, those who had scores ≥ 23 were assessed through semi-structured psychiatric interviews.
  
  
  RESULTS
  Thirty out of 256 subjects had no significant psychiatric symptoms after performing GHQ28. In further psychiatric evaluation of the remaining subjects (226) who suffered from some degree of a psychiatric problem, 36 were diagnosed without Anxiety/Depressive disorder. Thus 66 subjects (25.8%) were known as a group without any significant psychiatric problem. A total of 190 subjects (74.2%) with anxiety-depressive problems were diagnosed; 89 were suffering from pure anxiety disorders, 41 were suffering from depressive disorders and 60 had co-morbid anxiety-depressive disorders. When comparing anxiety-depressive patients (n = 190) with normal subjects (n = 66), gender (P = 0.016), occupation (P = 0.002) and intensity of IBS (P < 0.001) showed statistically significant differences.
  
  
  CONCLUSIONS
  The high prevalence of anxiety-depressive disorders in this study indicates the necessity of psychiatric assessment, early diagnosis and treatment of the patients with IBS. It may improve management of the patients suffering from IBS.
authors.affiliation: Department of Psychiatry, Guilan University of Medical Sciences, Rasht, Iran.
authors.forename: Mohamad-Jafar
authors.initials: MJ
authors.lastname: Modabbernia
authors.forename: Fariborz
authors.initials: F
authors.lastname: Mansour-Ghanaei
authors.forename: Ali
authors.initials: A
authors.lastname: Imani
authors.forename: Seyed-Alireza
authors.initials: SA
authors.lastname: Mirsafa-Moghaddam
authors.forename: Massih
authors.initials: M
authors.lastname: Sedigh-Rahimabadi
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Yousefi-Mashhour
authors.forename: Farahnaz
authors.initials: F
authors.lastname: Joukar
authors.forename: Zahra
authors.initials: Z
authors.lastname: Atrkar-Roushan
authors.forename: Siamak
authors.initials: S
authors.lastname: Bidel
mesh_terms: D000328:Adult; D001008:Anxiety Disorders / Q000175:diagnosis / Q000453:epidemiology*; D015897:Comorbidity; D003430:Cross-Sectional Studies; D003866:Depressive Disorder / Q000175:diagnosis / Q000453:epidemiology*; D004522:Educational Status; D005260:Female; D006801:Humans; D007406:Interview, Psychological / Q000379:methods; D007492:Iran / Q000453:epidemiology; D043183:Irritable Bowel Syndrome / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D055815:Young Adult