title: Drug coated balloons in acute coronary syndromes--opportunities and limitations.
abstract: Currently available data on drug coated balloon (DCB) angioplasty as a clinical treatment modality for coronary and peripheral artery disease are limited but hold promise. Advantages over standard angioplasty and stent technologies include a homogeneous drug delivery to the vessel wall, an immediate drug release without the use of a polymer, the option of using balloon catheters alone or in combination with a bare metal stent, no foreign object left behind in the body, the potential of reducing anti-platelet therapy, and a lower restenosis rates in some indications. The clinical and angiographic presentation of patients with acute coronary syndrome (ACS) is heterogeneous. Therefore, different clinical scenarios of DCB application in ACS may be discussed. Frequently, thrombosis in the ACS-related lesion plays a major role. Patients in hemodynamic critical situations under catecholamine therapy may present with too small vessel diameters. Another clinically relevant scenario represents in-stent restenosis (ISR) which is frequently associated with ACS.
authors.affiliation: Clinical and Experimental Interventional Cardiology, Internal Medicine III, University Hospital of Saarland, Homburg/Saar, Germany. Bruno.Scheller@uniklinikum-saarland.de.
authors.forename: Bruno
authors.initials: B
authors.lastname: Scheller
authors.forename: Yvonne
authors.initials: Y
authors.lastname: Clever
authors.forename: Michael
authors.initials: M
authors.lastname: Böhm
authors.forename: Bodo
authors.initials: B
authors.lastname: Cremers
mesh_terms: D054058:Acute Coronary Syndrome / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects / Q000379:methods; D000818:Animals; D000925:Anticoagulants / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D001145:Arrhythmias, Cardiac / Q000188:drug therapy / Q000503:physiopathology / Q000601:surgery; D003131:Combined Modality Therapy; D023903:Coronary Restenosis / Q000188:drug therapy / Q000517:prevention & control / Q000601:surgery; D016503:Drug Delivery Systems / Q000009:adverse effects; D006801:Humans; D017239:Paclitaxel / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D015607:Stents / Q000009:adverse effects; D013499:Surface Properties; D013927:Thrombosis / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control / Q000601:surgery
chemical_list: D000925:Anticoagulants; D010975:Platelet Aggregation Inhibitors; D017239:Paclitaxel