title: Tumor microenvironment and breast cancer progression: a complex scenario.
abstract: It is now widely accepted that the development and progression of a tumor toward the malignant phenotype is highly dependent on interactions between tumor cells and the tumor microenvironment. Different components of the tumor microenvironment may have stimulatory or inhibitory effects on tumor progression by regulating the gene expression repertoire in tumor cells and stromal cells. This review analyzes novel research findings on breast cancer progression, discussing acquisition of the metastatic phenotype in breast disease in relation to different aspects of cross-talk among components of the tumor microenvironment. Knowledge of the interaction of all of these factors would contribute to elucidating the mechanisms that disrupt regulatory/signaling cascades and downstream effects in breast cancer.
authors.affiliation: Department of Radiology and Medical Physics, University of Granada, Granada, Spain.
authors.forename: Antonia
authors.initials: A
authors.lastname: Artacho-Cordón
authors.forename: Francisco
authors.initials: F
authors.lastname: Artacho-Cordón
authors.forename: Sandra
authors.initials: S
authors.lastname: Ríos-Arrabal
authors.forename: Irene
authors.initials: I
authors.lastname: Calvente
authors.forename: María Isabel
authors.initials: MI
authors.lastname: Núñez
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D018450:Disease Progression; D057890:Epigenomics; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D059016:Tumor Microenvironment