title: NAD+ as a signaling molecule modulating metabolism.
abstract: The ability of NAD(+) to act as a metabolic cofactor and as a rate-limiting cosubstrate for many enzymes, particularly the sirtuins, has led to the identification of a pivotal role of NAD(+) levels in the control of whole-body metabolic homeostasis. Bioavailability and compartmentalization of NAD(+) have become highly relevant issues that we need to understand in order to elucidate how NAD(+) acts both as a readout of the metabolic milieu and as an effector triggering appropriate cellular adaptations.
authors.affiliation: Nestlé Institute of Health Sciences, CH-1015, Lausanne, Switzerland.
authors.forename: C
authors.initials: C
authors.lastname: Cantó
authors.forename: J
authors.initials: J
authors.lastname: Auwerx
mesh_terms: D000818:Animals; D006801:Humans; D008660:Metabolism; D009243:NAD / Q000378:metabolism*; D015398:Signal Transduction; D037761:Sirtuins / Q000378:metabolism
chemical_list: D009243:NAD; D037761:Sirtuins