title: Effects of a short term supplementation of a fermented papaya preparation on biomarkers of diabetes mellitus in a randomized Mauritian population.
abstract: OBJECTIVE
  Clinical evidence and cellular models have shown an inverse relationship between the intakes of plant and fruit based diets and oxidative stress, suggesting the suitability of natural antioxidants in the management of diabetes mellitus and its complications.
  
  
  METHODS
  A randomized controlled clinical trial was conducted at the Cardiac Centre, SSRN Hospital, Pamplemousses, (Mauritius) to determine the effect of a short term supplementation of a fermented papaya preparation (FPP®) on biomarkers of diabetes and antioxidant status in a multi-ethnical neo-diabetic population from November 2010 to March 2011.
  
  
  RESULTS
  Supplementation of 6g FPP®/day for a period of 14 weeks could improve the general health status of several organs targeted by oxidative stress during diabetes. When comparing experimental to control groups with independent samples t-test, C-reactive protein levels significantly decreased (P=0.018), LDL/HDL ratio was considerably changed (P=0.042), and uric acid levels were significantly improved (P=0.001). ANOVA results also validated the same findings with significant differences in C-reactive protein, LDL/HDL ratio, uric acid and in serum ferritin levels.
  
  
  CONCLUSIONS
  FPP® may present a novel, economically feasible nutraceutical supplement for the management of diabetes and for those at risk for cardiovascular disease, neurological disease and other conditions worsened by overt inflammation and oxidative stress.
authors.affiliation: ANDI Centre of Excellence for Biomedical and Biomaterials Research and Department of Biosciences University of Mauritius, Réduit, Republic of Mauritius.
authors.forename: Jhoti
authors.initials: J
authors.lastname: Somanah
authors.forename: Okezie I
authors.initials: OI
authors.lastname: Aruoma
authors.forename: Teeluck K
authors.initials: TK
authors.lastname: Gunness
authors.forename: Sudhir
authors.initials: S
authors.lastname: Kowelssur
authors.forename: Venkatesh
authors.initials: V
authors.lastname: Dambala
authors.forename: Fatima
authors.initials: F
authors.lastname: Murad
authors.forename: Kreshna
authors.initials: K
authors.lastname: Googoolye
authors.forename: Diana
authors.initials: D
authors.lastname: Daus
authors.forename: Joseph
authors.initials: J
authors.lastname: Indelicato
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Bourdon
authors.forename: Theeshan
authors.initials: T
authors.lastname: Bahorun
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism*; D029441:Carica / Q000737:chemistry*; D003920:Diabetes Mellitus / Q000178:diet therapy*; D019587:Dietary Supplements; D005260:Female; D005285:Fermentation; D006801:Humans; D008297:Male; D008435:Mauritania; D008875:Middle Aged; D008517:Phytotherapy; D028321:Plant Preparations / Q000494:pharmacology*
chemical_list: D015415:Biomarkers; D028321:Plant Preparations