title: Bioengineered prosthesis with allogenic heterotopic fibroblasts for cricoid regeneration.
abstract: OBJECTIVE
  This study aimed to determine the effectiveness of a bioengineered prosthesis with allogenic heterotopic fibroblasts for cricoid regeneration.
  
  
  METHODS
  Experimental study using a rat model.
  
  
  METHODS
  Bioengineered prosthetic grafts consisting of collagen sponge, polypropylene mesh, collagen gel, and allogenic dermal fibroblasts were implanted into rat cricoid defects. Control grafts were composed of collagen sponge and polypropylene mesh. Regenerated subglottic tissue was subsequently examined histologically.
  
  
  RESULTS
  Epithelization and changes of collagen fibers occurred more rapidly in the bioengineered model than in the control model. Neogenetic cartilage was observed to form around the ends of cricoid cartilage in both models.
  
  
  CONCLUSIONS
  Heterotopic fibroblasts appear to accelerate epithelial and subepithelial regeneration in a rat model.
authors.affiliation: Department of Otolaryngology, School of Medicine, Fukushima Medical University, Fukushima, Japan.
authors.forename: Yukio
authors.initials: Y
authors.lastname: Nomoto
authors.forename: Wataru
authors.initials: W
authors.lastname: Okano
authors.forename: Mitsuyoshi
authors.initials: M
authors.lastname: Imaizumi
authors.forename: Akiko
authors.initials: A
authors.lastname: Tani
authors.forename: Mika
authors.initials: M
authors.lastname: Nomoto
authors.forename: Koichi
authors.initials: K
authors.lastname: Omori
mesh_terms: D000818:Animals; D003413:Cricoid Cartilage / Q000601:surgery*; D004195:Disease Models, Animal; D005347:Fibroblasts / Q000166:cytology / Q000637:transplantation*; D008297:Male; D019736:Prostheses and Implants; D051381:Rats; D017207:Rats, Sprague-Dawley; D012038:Regeneration / Q000502:physiology*; D020545:Respiratory Mucosa / Q000502:physiology*; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds; D014132:Trachea / Q000473:pathology; D014135:Tracheal Stenosis / Q000473:pathology / Q000601:surgery; D014184:Transplantation, Homologous; D014945:Wound Healing