title: A new triterpene From Uncaria macrophylla and its antitumor activity.
abstract: On our ongoing investigation, a new oleanolic triterpene, 3β,6β,19α-trihydroxy-12-oleanen-28-oic acid (1) was obtained from the chloroform-soluble portion of the 90% alcohol-water extract of the stem bark of Uncaria macrophylla. Its structure was elucidated by extensive spectroscopic methods, including 1D and 2D ((1)H-(1)H COSY, HSQC and HMBC) NMR and HR-ESI-MS. The cytotoxicities of the compound was evaluated against two cancer cell lines of MCF-7 and HepG2 by the MTT method, and the compound exhibited weak activities with the IC(50) values of 78.2 µg/mL and 73.9 µg/mL.
authors.affiliation: Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China. guanglisun@126.com
authors.forename: Guangli
authors.initials: G
authors.lastname: Sun
authors.forename: Xiaopo
authors.initials: X
authors.lastname: Zhang
authors.forename: Xudong
authors.initials: X
authors.lastname: Xu
authors.forename: Junshan
authors.initials: J
authors.lastname: Yang
authors.forename: Mingliang
authors.initials: M
authors.lastname: Zhong
authors.forename: Jingquan
authors.initials: J
authors.lastname: Yuan
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D021241:Spectrometry, Mass, Electrospray Ionization; D014315:Triterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D032070:Uncaria / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes