title: The distribution of immune cells in the lungs of classical and atypical ovine pulmonary adenocarcinoma.
abstract: Ovine pulmonary adenocarcinoma (OPA) is a contagious tumour caused by infection of sheep with Jaagsiekte sheep retrovirus. Two forms of OPA have been identified, classical and atypical, which can be distinguished clinically and pathologically. Most notably classical OPA is progressive until death, while atypical OPA remains subclinical. In the present study the local immune responses in the lungs of cases of atypical OPA were compared with those from classical cases by immunohistochemistry using a panel of mouse anti-sheep mAbs. Distinct differences in the distribution of immune cell subsets in the two forms of OPA were observed. In particular there was an intratumoural influx of T cell subsets and MHC Class II expression on the tumour cells in atypical OPA, neither of which was seen in classical OPA. It is possible that these differences may contribute, at least in part, to determining the progressive course of classical OPA compared with the subclinical nature of atypical OPA.
authors.affiliation: Departmento de Patologia Animal, Facultad de Veterinaria, Universidad de Zaragoza, c/Miguel Servet 177, 50013 Zaragoza, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Summers
authors.forename: A
authors.initials: A
authors.lastname: Benito
authors.forename: A
authors.initials: A
authors.lastname: Ortin
authors.forename: J A
authors.initials: JA
authors.lastname: Garcia de Jalon
authors.forename: L
authors.initials: L
authors.lastname: González
authors.forename: M
authors.initials: M
authors.lastname: Norval
authors.forename: J M
authors.initials: JM
authors.lastname: Sharp
authors.forename: M
authors.initials: M
authors.lastname: De las Heras
mesh_terms: D000230:Adenocarcinoma / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D007371:Interferon-gamma / Q000096:biosynthesis; D018950:Lipopolysaccharide Receptors / Q000032:analysis; D008168:Lung / Q000276:immunology* / Q000473:pathology; D008175:Lung Neoplasms / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D051379:Mice; D012756:Sheep; D012757:Sheep Diseases / Q000276:immunology* / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D000949:Histocompatibility Antigens Class II; D018950:Lipopolysaccharide Receptors; D007371:Interferon-gamma