title: Exercise increases skeletal muscle GLUT4 gene expression in patients with type 2 diabetes.
abstract: The aim of the study was to determine the effect of a single bout of exercise on GLUT4 gene expression in muscle of patients with type 2 diabetes (T2D) and control subjects, matched for age and body mass index. Nine patients with T2D and nine control subjects performed 60 min of cycling exercise at ~55% peak power (W(max) ). Skeletal muscle biopsies were obtained at baseline, immediately post and 3-h post exercise. GLUT4 mRNA expression increased (p < 0.05) to a similar extent immediately post exercise in control (~60%) and T2D (~66%) subjects, and remained elevated (p < 0.05) 3-h post exercise with no differences between groups. Similarly, p-AMP-activated protein kinase, p38 mitogen-activated kinase and proliferator-activated receptor gamma co-activator-alpha mRNA expression were increased (p < 0.05) post exercise, and were not different between the groups. In conclusion, a single bout of exercise increased skeletal muscle GLUT4 mRNA expression in patients with T2D to a similar extent as in control subjects.
authors.forename: S E
authors.initials: SE
authors.lastname: Hussey
authors.forename: S L
authors.initials: SL
authors.lastname: McGee
authors.forename: A
authors.initials: A
authors.lastname: Garnham
authors.forename: G K
authors.initials: GK
authors.lastname: McConell
authors.forename: M
authors.initials: M
authors.lastname: Hargreaves
mesh_terms: D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism* / Q000473:pathology; D015444:Exercise; D005260:Female; D015870:Gene Expression; D051275:Glucose Transporter Type 4 / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000378:metabolism / Q000473:pathology*; D014157:Transcription Factors
chemical_list: D051275:Glucose Transporter Type 4; D014157:Transcription Factors