title: Anti-cytokine vaccination: a new biotherapy of autoimmunity?
abstract: Anti-cytokine vaccination is an innovative strategy of targeted, active immunotherapy with potential application in autoimmune diseases. The principle is to design molecules capable of triggering a humoral immune response versus a cytokine with a recognized pathogenic role in a given disease. The most used vaccination approach is based on self-protein coupled to a carrier. This strategy proved particular efficacy in models of TNF-α-dependent diseases, and promising results come from recent clinical trials in rheumatoid arthritis and Crohn's disease. The benefit/risk ratio and long term safety of anti-cytokine vaccination need to be determined to further develop this therapeutic strategy.
authors.affiliation: Sorbonne Paris Cité University, Paris 13 University, Bobigny, France.
authors.forename: Luca
authors.initials: L
authors.lastname: Semerano
authors.forename: Eric
authors.initials: E
authors.lastname: Assier
authors.forename: Marie-Christophe
authors.initials: MC
authors.lastname: Boissier
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology* / Q000517:prevention & control / Q000628:therapy*; D015551:Autoimmunity / Q000276:immunology*; D016207:Cytokines / Q000276:immunology* / Q000627:therapeutic use*; D006801:Humans; D016233:Immunotherapy, Active; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology / Q000627:therapeutic use; D014611:Vaccination; D042461:Vascular Endothelial Growth Factor A / Q000276:immunology / Q000627:therapeutic use
chemical_list: D016207:Cytokines; D014409:Tumor Necrosis Factor-alpha; D042461:Vascular Endothelial Growth Factor A