title: [Cold pathology and experimental therapy of deep hypothermia].
abstract: A complete cold paralysis of respiration and thermoregulation occurs in rats at the temperature in the brain 16.6 +/- 0.3 and in the rectum 15.2 +/- 0.3 degrees C. Under the conditions of room temperature 18-19 degrees C, the respiration never restores, and the animals die. This is believed [6] to be the result of calcium ion Ca2+ accumulation in the cells of respiration and thermoregulation centers. After the arrest of respiration the animals were injected with the solution of disodium salt of ethylenediaminetetraacetic acid (Na2EDTA), which binds calcium ions in the blood and facilitates their removal from the cell (explanations in the text). In 7-9 min after the injection the calcium content in the blood decreased and the respiration began to restore at the temperature of the cold paralysis. Thermoregulation was also restored. All the test animals survived. All the control animals, which were not injected with Na2EDTA, died.
authors.forename: K P
authors.initials: KP
authors.lastname: Ivanov
authors.forename: N K
authors.initials: NK
authors.lastname: Arokina
authors.forename: G S
authors.initials: GS
authors.lastname: Fedorova
mesh_terms: D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects; D002118:Calcium / Q000097:blood*; D002614:Chelating Agents / Q000494:pharmacology*; D003080:Cold Temperature / Q000009:adverse effects*; D004492:Edetic Acid / Q000494:pharmacology*; D007035:Hypothermia / Q000097:blood* / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D010243:Paralysis / Q000097:blood / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D012119:Respiration / Q000187:drug effects
chemical_list: D002614:Chelating Agents; D004492:Edetic Acid; D002118:Calcium