title: Antimicrobial metabolites from the Paracel Islands sponge Agelas mauritiana.
abstract: Four new alkaloids, (-)-8'-oxo-agelasine D (2), ageloxime B (3), (+)-2-oxo-agelasidine C (4), and 4-bromo-N-(butoxymethyl)-1H-pyrrole-2-carboxamide (5), and the known compound (-)-ageloxime D (1) were isolated from the marine sponge Agelas mauritiana. Their chemical structures were established on the basis of spectroscopic analysis. Compounds 1 and 3 both showed antifungal activity against Cryptococcus neoformans and antileishmanial activity against Leishmania donovani in vitro. Compound 3 also exhibited antibacterial activity against Staphylococcus aureus and methicillin-resistant S. aureusin vitro.
authors.affiliation: Laboratory of Marine Drugs, Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai, 200003, People's Republic of China.
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.forename: Mark T
authors.initials: MT
authors.lastname: Hamann
authors.forename: Yike
authors.initials: Y
authors.lastname: Zou
authors.forename: Ming-Yu
authors.initials: MY
authors.lastname: Zhang
authors.forename: Xiao-Bin
authors.initials: XB
authors.lastname: Gong
authors.forename: Jian-Ru
authors.initials: JR
authors.lastname: Xiao
authors.forename: Wan-Sheng
authors.initials: WS
authors.lastname: Chen
authors.forename: Hou-Wen
authors.initials: HW
authors.lastname: Lin
mesh_terms: D047230:Agelas / Q000737:chemistry*; D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D003455:Cryptococcus neoformans / Q000187:drug effects; D007893:Leishmania donovani / Q000187:drug effects; D008386:Marine Biology; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013203:Staphylococcal Infections / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000470:Alkaloids; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents