title: Convection enhanced delivery of macromolecules for brain tumors.
abstract: The blood brain barrier (BBB) poses a significant challenge for drug delivery of macromolecules into the brain. Convection-enhanced delivery (CED) circumvents the BBB through direct intracerebral infusion using a hydrostatic pressure gradient to transfer therapeutic compounds. The efficacy of CED is dependent on the distribution of the therapeutic agent to the targeted region. Here we present a review of convection enhanced delivery of macromolecules, emphasizing the role of tracers in enabling effective delivery anddiscuss current challenges in the field.
authors.affiliation: Division of Neurosurgery, Duke University Medical Center, Durham, NC 27710, USA. ankit.mehta@duke.edu
authors.forename: Ankit I
authors.initials: AI
authors.lastname: Mehta
authors.forename: Bryan D
authors.initials: BD
authors.lastname: Choi
authors.forename: Divya
authors.initials: D
authors.lastname: Ajay
authors.forename: Raghu
authors.initials: R
authors.lastname: Raghavan
authors.forename: Martin
authors.initials: M
authors.lastname: Brady
authors.forename: Allan H
authors.initials: AH
authors.lastname: Friedman
authors.forename: Ira
authors.initials: I
authors.lastname: Pastan
authors.forename: Darell D
authors.initials: DD
authors.lastname: Bigner
authors.forename: John H
authors.initials: JH
authors.lastname: Sampson
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D001932:Brain Neoplasms / Q000188:drug therapy*; D016503:Drug Delivery Systems; D006801:Humans; D008279:Magnetic Resonance Imaging
chemical_list: D000970:Antineoplastic Agents