title: Galactolipids from Bauhinia racemosa as a new class of antifilarial agents against human lymphatic filarial parasite, Brugia malayi.
abstract: Bioassay guided fractionation of ethanolic extract of the leaves of Bauhinia racemosa led to the isolation of galactolipid and catechin class of the compounds (1-7) from the most active n-butanol fraction (F4). Among the active galactolipids, 1 emerged as the lead molecule which was active on both forms of lymphatic filarial parasite, Brugia malayi. It was found to be better than the standard drug ivermectin and diethylcarbamazine (DEC) in terms of dose and efficacy.
authors.affiliation: Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute, Chattar Manzil Palace, Lucknow 226 001, India. sashidhar123@gmail.com
authors.forename: Koneni V
authors.initials: KV
authors.lastname: Sashidhara
authors.forename: Suriya P
authors.initials: SP
authors.lastname: Singh
authors.forename: Sweta
authors.initials: S
authors.lastname: Misra
authors.forename: Jyoti
authors.initials: J
authors.lastname: Gupta
authors.forename: Shailja
authors.initials: S
authors.lastname: Misra-Bhattacharya
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000302:isolation & purification / Q000494:pharmacology; D036481:Bauhinia / Q000737:chemistry*; D017178:Brugia malayi / Q000187:drug effects*; D004049:Diethylcarbamazine / Q000627:therapeutic use; D004605:Elephantiasis, Filarial / Q000188:drug therapy* / Q000469:parasitology; D005369:Filaricides / Q000302:isolation & purification* / Q000494:pharmacology*; D038983:Galactolipids / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D007559:Ivermectin / Q000627:therapeutic use; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry
chemical_list: D000871:Anthelmintics; D005369:Filaricides; D038983:Galactolipids; D010936:Plant Extracts; D007559:Ivermectin; D004049:Diethylcarbamazine