title: [Comparison of white matter integrity of schizophrenic patients with and without impulsive behaviors by diffusion tensor magnetic resonance imaging].
abstract: OBJECTIVE
  To compare the regional white matter integrity of schizophrenics with impulsive behaviors versus those without.
  
  
  METHODS
  Seventeen patients with first-episode-schizophrenia impulsive behaviors and 24 patients with first-episode-schizophrenia non-impulsive behaviors underwent diffusion weighted magnetic resonance imaging with a single-shot echo planar imaging (EPI) sequence aligned to straight axial plane. The fractional anisotropy (FA) images of two groups received two-sample t-test with SPM5 software.
  
  
  RESULTS
  The patients with impulsive behaviors demonstrated a significant decrement of white matter FA values in left precentral gyrus (MNI: x = -28.00, y = -28.72, z = -54.71; cluster = 79 voxels), left cerebellum anterior lobe (MNI: x = -22, y = -56, z = -28; cluster = 130 voxels) and left occipital lobe (MNI: x = -6, y = -72, z = 6; cluster = 54 voxels).
  
  
  CONCLUSIONS
  The altered white matter integrity of left precentral gyrus, cerebellum anterior lobe and occipital lobe may be involved in the neural mechanism of impulsive behaviors in schizophrenia.
authors.affiliation: Department of Psychiatry, Third Affiliated Hospital, SUN Yat-sen University, Guangzhou, China. weiql.yuelu@yahoo.com.cn
authors.forename: Qin-ling
authors.initials: QL
authors.lastname: Wei
authors.forename: Zi-li
authors.initials: ZL
authors.lastname: Han
authors.forename: Xiao-li
authors.initials: XL
authors.lastname: Wu
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Kang
authors.forename: Lei-jun
authors.initials: LJ
authors.lastname: Li
authors.forename: Liang-rong
authors.initials: LR
authors.lastname: Zheng
authors.forename: Xiao-feng
authors.initials: XF
authors.lastname: Guo
authors.forename: Jing-ping
authors.initials: JP
authors.lastname: Zhao
authors.forename: Jin-bei
authors.initials: JB
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000473:pathology*; D001931:Brain Mapping; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D006801:Humans; D007175:Impulsive Behavior / Q000503:physiopathology*; D008297:Male; D012559:Schizophrenia / Q000473:pathology*; D012565:Schizophrenic Psychology; D055815:Young Adult