title: Critical review of mouse models of venous thrombosis.
abstract: Deep vein thrombosis and pulmonary embolism are a significant health care concern, representing a major source of mortality and morbidity. In order to understand the pathophysiology of thrombogenesis and thrombus resolution, animal models are necessary. Mouse models of venous thrombosis contribute to our understanding of the initiation, propagation, and resolution of venous thrombus, as well as allow for the evaluation of new pharmaceutical approaches to prophylaxis and treatment of deep vein thrombosis. In this work we review the ferric chloride model, the inferior vena cava ligation model, the inferior vena cava stenosis models, and the electrolytic inferior vena cava model and compare their advantages and disadvantages.
authors.affiliation: Department of Surgery, Conrad Jobst Vascular Research Laboratories, University of Michigan, A570 MSRB II, Dock #6, 1150 W. Medical Center Drive, Ann Arbor, MI 48109-0654, USA. josediaz@med.umich.edu
authors.forename: Jose A
authors.initials: JA
authors.lastname: Diaz
authors.forename: Andrea T
authors.initials: AT
authors.lastname: Obi
authors.forename: Daniel D
authors.initials: DD
authors.lastname: Myers
authors.forename: Shirley K
authors.initials: SK
authors.lastname: Wrobleski
authors.forename: Peter K
authors.initials: PK
authors.lastname: Henke
authors.forename: Nigel
authors.initials: N
authors.lastname: Mackman
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Wakefield
mesh_terms: D000818:Animals; D002712:Chlorides; D003250:Constriction; D004195:Disease Models, Animal; D004572:Electrolysis; D005290:Ferric Compounds; D008026:Ligation; D051379:Mice; D014682:Vena Cava, Inferior / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery; D020246:Venous Thrombosis / Q000097:blood / Q000209:etiology / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy
chemical_list: D002712:Chlorides; D005290:Ferric Compounds; C024555:ferric chloride