title: A Common variant near the melanocortin 4 receptor is associated with low-density lipoprotein cholesterol and total cholesterol in the Chinese Han population.
abstract: A number of recent genome-wide association studies in European populations have reported that variant rs17782313 is significantly associated with obesity and body mass index (BMI). The purpose of the present study was to evaluate the association of rs17782313 with obesity and BMI in the Chinese Han population. We also sought to extend previous studies by determining whether this SNP is associated with plasma lipid levels in the Chinese Han population. Rs17782313 was genotyped in two independent Chinese Han cohorts (Cohort1: n = 2533; Cohort2: n = 2105). In our study, rs17782313 did not show significant association with either obesity or BMI in the Chinese Han population, but showed evidence for association with LDL-C (P ~ 0.003) and TC (P ~ 0.001). Our findings indicate that the variant rs17782313 near MC4R is likely to have an impact on plasma lipid levels of LDL-C and TC in the Chinese Han population.
authors.affiliation: Graduate School of the Chinese Academy of Sciences, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, People's Republic of China.
authors.forename: Liming
authors.initials: L
authors.lastname: Tao
authors.forename: Zhou
authors.initials: Z
authors.lastname: Zhang
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Chen
authors.forename: Daizhan
authors.initials: D
authors.lastname: Zhou
authors.forename: Weidong
authors.initials: W
authors.lastname: Li
authors.forename: Mengyuan
authors.initials: M
authors.lastname: Kan
authors.forename: Di
authors.initials: D
authors.lastname: Zhang
authors.forename: Lin
authors.initials: L
authors.lastname: He
authors.forename: Guoying
authors.initials: G
authors.lastname: Huang
authors.forename: Yun
authors.initials: Y
authors.lastname: Liu
mesh_terms: D000368:Aged; D044466:Asian People; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D044105:Receptor, Melanocortin, Type 4 / Q000235:genetics*; D017422:Sequence Analysis, DNA; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D044105:Receptor, Melanocortin, Type 4; D014280:Triglycerides; D002784:Cholesterol