title: Interactions between solubilized polymer molecules and blood components.
abstract: In biomedical field, a variety of natural or synthetic polymers are being exponentially developed and used in vivo to improve human health. In practical applications, these biopolymers would enter blood circulation directly or indirectly, positively or passively, rapidly or slowly. Blood is a special tissue of human body, which fulfills many important missions to sustain normal metabolism. The contact with blood of the biopolymers, which are seen as foreign substances by the body, would be harmful or even instantaneously lethal, depending on the nature and the dose of the biopolymers administered. Therefore, it is critical to clearly understand the potential influences of the foreign polymers on blood before the polymers are applied from the lab to bedside. In this review, we discuss the recent studies on the interactions of foreign, solubilized polymer molecules (excluding formed polymer materials) with blood constituents (red blood cells, white blood cells, platelets, plasma proteins, etc.), to gain insight into the potential in vivo applications of the biopolymers in the biomedical field.
authors.affiliation: Institutes of Life and Health Engineering, Jinan University, Guangzhou, China.
authors.forename: Zonghua
authors.initials: Z
authors.lastname: Liu
authors.forename: Yanpeng
authors.initials: Y
authors.lastname: Jiao
authors.forename: Tong
authors.initials: T
authors.lastname: Wang
authors.forename: Yuanming
authors.initials: Y
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Xue
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000009:adverse effects* / Q000737:chemistry / Q000493:pharmacokinetics; D001704:Biopolymers / Q000009:adverse effects* / Q000097:blood / Q000737:chemistry; D001773:Blood Cells / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D002462:Cell Membrane / Q000187:drug effects; D004337:Drug Carriers / Q000009:adverse effects* / Q000737:chemistry / Q000493:pharmacokinetics; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008074:Lipoproteins / Q000378:metabolism; D008564:Membrane Potentials / Q000187:drug effects; D008565:Membrane Proteins / Q000378:metabolism; D015394:Molecular Structure; D012709:Serum Albumin / Q000378:metabolism; D012995:Solubility; D055672:Static Electricity; D013499:Surface Properties
chemical_list: D001672:Biocompatible Materials; D001704:Biopolymers; D004337:Drug Carriers; D008074:Lipoproteins; D008565:Membrane Proteins; D012709:Serum Albumin