title: Novel norlignan glucosides from rhizomes of Curculigo sinensis.
abstract: Eight norlignan glucosides, including two novel skeleton-rearranged compounds, sinenside A (1) and B (2), and six known compounds, crassifoside D (3), capituloside (4), a mixture of (1S,2R)-1-O-methylnyasicoside (5), (1R,2R)-1-O-methylisonyasicoside (6), and a mixture of (1S,2R)-1-O-methylcurculigine (7) and (1R,2R)-1-O-methylisocurculigine (8), were isolated from the rhizomes of Curculigo sinensis. Compounds 3-8 were isolated for the first time from this plant. Structures of the isolated compounds were established by spectroscopic analysis, including UV, IR, HRESI-MS, and 1D/2D NMR, and hydrolysis experiments. The free radical scavenging activity of the isolated compounds was evaluated by the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. All the isolated compounds showed strong radical scavenging activities.
authors.affiliation: Anhui Key Laboratory of Bioactivity of Natural Products, School of Pharmacy, Anhui Medical University, 81 Meishan Road, Hefei 230032, PR China. ln0110@sina.com
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.forename: Shi-Ping
authors.initials: SP
authors.lastname: Li
authors.forename: Kai-Jin
authors.initials: KJ
authors.lastname: Wang
authors.forename: Guo-Qing
authors.initials: GQ
authors.lastname: Yan
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Zhu
mesh_terms: D001713:Biphenyl Compounds / Q000737:chemistry; D002236:Carbohydrate Conformation; D031408:Curculigo / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000737:chemistry* / Q000302:isolation & purification*; D005960:Glucosides / Q000737:chemistry* / Q000302:isolation & purification*; D017705:Lignans / Q000737:chemistry*; D008958:Models, Molecular; D010851:Picrates / Q000737:chemistry; D027343:Rhizome / Q000737:chemistry*
chemical_list: D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D005960:Glucosides; D017705:Lignans; D010851:Picrates; C004931:1,1-diphenyl-2-picrylhydrazyl