title: Differential requirements of mammalian ESCRTs in multivesicular body formation, virus budding and cell division.
abstract: The endosomal sorting complexes required for transport (ESCRTs) mediate membrane fission from the cytoplasmic face of the bud neck. ESCRTs were originally identified as factors involved in multivesicular body vesicle biogenesis in yeast but have since been shown to function in other membrane fission events in mammalian cells, including enveloped virus budding and the abscission step of cytokinesis. Several recent studies have revealed that not all ESCRT factors are required for each of these biological processes, and this review summarizes our current understanding of the different requirements for ESCRT factors in these three different ESCRT-mediated mammalian membrane fission processes.
authors.affiliation: Laboratory of Viral Infection, International Research Center for Infectious Diseases, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan. moritae@biken.osaka-u.ac.jp
authors.forename: Eiji
authors.initials: E
authors.lastname: Morita
mesh_terms: D000818:Animals; D002455:Cell Division / Q000502:physiology*; D056827:Endosomal Sorting Complexes Required for Transport / Q000378:metabolism*; D006801:Humans; D057146:Multivesicular Bodies / Q000502:physiology*; D057074:Virus Release
chemical_list: D056827:Endosomal Sorting Complexes Required for Transport