title: [Treatment of septic shock in children with low dose pituitrin: report of 24 cases].
abstract: OBJECTIVE
  To explore the clinical effect of low dose pituitrin in children with septic shock.
  
  
  METHODS
  A total of 48 pediatric cases with septic shock, in whom 6 hours, conventional treatment could not reverse shock from January 2008 to December 2010, were selected for this study. The patients were divided into two groups randomly (completely random design) (control group 24, remedial group 24). The conventional treatment included antibiotics/fluid resuscitation/correcting acid-base imbalance, glucocorticoid, organ (heart/lung) support, dopamine 1 - 15 µg/(kg·min) and norepinephrine 0.5 - 2 µg/(kg·min) pumped in continuously in the control group. In initial 6 hours the same treatment was given to the remedial group, while low dose pituitrin (0.01 - 0.03 U/min) was pumped additionally during the rest of time. The therapeutic effect on correcting shock was evaluated in both groups.
  
  
  RESULTS
  The total effective rate was 76.2% in the remedial group and 40.0% in the control group; the mortality was 33.3% and 60% respectively. The difference between both groups was significant (P = 0.025).
  
  
  CONCLUSIONS
  Low dose pituitrin could improve the clinical effect significantly in children with septic shock in whom 6 hours conventional treatment failed to correct shock, shorten the total periods of treatment, and decrease mortality.
authors.affiliation: Department of Pediatrics, Hu Bei University of Medicine, Shiyan, China.
authors.forename: Zi-jiang
authors.initials: ZJ
authors.lastname: Yang
authors.forename: Jing-feng
authors.initials: JF
authors.lastname: Li
authors.forename: Li-min
authors.initials: LM
authors.lastname: Fu
authors.forename: Shang-bing
authors.initials: SB
authors.lastname: Lei
authors.forename: Jun-hua
authors.initials: JH
authors.lastname: Liu
authors.forename: Yong
authors.initials: Y
authors.lastname: Wu
authors.forename: Yan-ping
authors.initials: YP
authors.lastname: Hu
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009638:Norepinephrine / Q000627:therapeutic use; D010909:Pituitary Hormones, Posterior / Q000008:administration & dosage / Q000627:therapeutic use*; D012772:Shock, Septic / Q000188:drug therapy*; D016896:Treatment Outcome; D014662:Vasoconstrictor Agents / Q000627:therapeutic use
chemical_list: D010909:Pituitary Hormones, Posterior; D014662:Vasoconstrictor Agents; D009638:Norepinephrine