title: Schilancitrilactones A-C: three unique nortriterpenoids from Schisandra lancifolia.
abstract: Three unique nortriterpenoids, schilancitrilactones A-C (1-3), were isolated from the stems of Schisandra lancifolia . Compound 1 possesses a 5/5/7/5/5/5-fused hexacyclic ring system with a C(29) backbone, while 2 and 3 feature a C(27) skeleton with a 5/7/5/5/5-fused pentacyclic ring system. Their absolute stereochemistries were established by CD and single-crystal X-ray diffraction experiments. Compound 3 showed anti-HIV-1 activity with an EC(50) value of 27.54 μg/mL, and 1 exhibited antifeedant activity at 15.73 μg/cm(2).
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, People's Republic of China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Luo
authors.forename: Yi-Ming
authors.initials: YM
authors.lastname: Shi
authors.forename: Rong-Hua
authors.initials: RH
authors.lastname: Luo
authors.forename: Shi-Hong
authors.initials: SH
authors.lastname: Luo
authors.forename: Xiao-Nian
authors.initials: XN
authors.lastname: Li
authors.forename: Rui-Rui
authors.initials: RR
authors.lastname: Wang
authors.forename: Sheng-Hong
authors.initials: SH
authors.lastname: Li
authors.forename: Yong-Tang
authors.initials: YT
authors.lastname: Zheng
authors.forename: Xue
authors.initials: X
authors.lastname: Du
authors.forename: Wei-Lie
authors.initials: WL
authors.lastname: Xiao
authors.forename: Jian-Xin
authors.initials: JX
authors.lastname: Pu
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects; D008958:Models, Molecular; D032141:Schisandra / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D019380:Anti-HIV Agents; D014315:Triterpenes; C572280:schilancitrilactone A; C572278:schilancitrilactone B; C572279:schilancitrilactone C