title: [C+NC+CC] coupling-enabled synthesis of influenza neuramidase inhibitor A-315675.
abstract: An efficient synthesis of the neuramidase inhibitor A-315675 is reported. The fully functionalized pyrrolidine core of the target is assembled in one pot via an exo-selective asymmetric [C+NC+CC] coupling reaction.
authors.affiliation: Department of Chemistry, Washington State University, Pullman, Washington 99164-4630, USA. ppg@wsu.edu
authors.forename: Philip
authors.initials: P
authors.lastname: Garner
authors.forename: Laksiri
authors.initials: L
authors.lastname: Weerasinghe
authors.forename: Wiley J
authors.initials: WJ
authors.lastname: Youngs
authors.forename: Brian
authors.initials: B
authors.lastname: Wright
authors.forename: Dean
authors.initials: D
authors.lastname: Wilson
authors.forename: Dylan
authors.initials: D
authors.lastname: Jacobs
mesh_terms: D004791:Enzyme Inhibitors / Q000138:chemical synthesis*; D008958:Models, Molecular; D015394:Molecular Structure; D009439:Neuraminidase / Q000037:antagonists & inhibitors*; D009975:Orthomyxoviridae / Q000201:enzymology*; D011759:Pyrrolidines / Q000138:chemical synthesis*; D013237:Stereoisomerism
chemical_list: C456059:A 315675; D004791:Enzyme Inhibitors; D011759:Pyrrolidines; D009439:Neuraminidase