title: Scope of direct arylation of fluorinated aromatics with aryl sulfonates.
abstract: The scope and limitations of direct arylation of fluorinated aromatics with aryl sulfonates was examined. Pd(OAc)(2), in the presence of MePhos and KOAc in THF, efficiently catalyzed the direct arylation of fluoro aromatics with aryl triflates under ambient conditions. Sterically hindered triflates and heteroaryl triflates gave good to excellent yields of the cross coupled products using a modified catalyst system which involves Pd(OAc)(2)-RuPhos at 100 °C. The direct arylation of electron deficient arenes with aryl mesylates is also established using Pd(OAc)(2)-SPhos as the catalyst in toluene-(t)BuOH at 120 °C.
authors.affiliation: Institute of Chemical and Engineering Sciences, 8 Biomedical Grove, Neuros, #07-01, Singapore 138665, Singapore.
authors.forename: Joyce Wei Wei
authors.initials: JW
authors.lastname: Chang
authors.forename: Eugene Yurong
authors.initials: EY
authors.lastname: Chia
authors.forename: Christina Li Lin
authors.initials: CL
authors.lastname: Chai
authors.forename: Jayasree
authors.initials: J
authors.lastname: Seayad
mesh_terms: D001190:Arylsulfonates / Q000737:chemistry*; D002384:Catalysis; D054879:Halogenation; D007854:Lead / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D001190:Arylsulfonates; D007854:Lead