title: [Effect of formaldehyde in low concentrations on the proliferation and organization of the cytoskeleton of cultured cells].
abstract: 3-4% (1.07-1.42 M) formaldehyde is one of the most popular and well-known organs, tissues and cells fixer. In this manuscript we have shown that formaldehyde in concentrations of up to 60 microM (0.0002%) does not have any negative effect on the viability of cell lines A431, HEK293 and primary rat fibroblasts, but it is also increases the proliferative activity of A431. The influence on A431 cells might be explained by the activation of epidermal growth factor receptors as a result of their interaction with formaldehyde.
authors.forename: A A
authors.initials: AA
authors.lastname: Aĭzenshtadt
authors.forename: E B
authors.initials: EB
authors.lastname: Burova
authors.forename: V V
authors.initials: VV
authors.lastname: Zenin
authors.forename: D E
authors.initials: DE
authors.lastname: Bobkov
authors.forename: I V
authors.initials: IV
authors.lastname: Kropacheva
authors.forename: G P
authors.initials: GP
authors.lastname: Pinaev
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D003599:Cytoskeleton / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism*; D005404:Fixatives / Q000494:pharmacology*; D005557:Formaldehyde / Q000494:pharmacology*; D057809:HEK293 Cells; D006801:Humans; D051381:Rats
chemical_list: D005404:Fixatives; D005557:Formaldehyde