title: [In vitro evaluation of the gels properties prepared thermosensitive polymers as vehicles for administration substance by injection].
abstract: The aim of this study was to prepare a thermoresponsive formulations, which are a carrier for substance administered directly into site of action and which obtain sol-gel transitions at physiological ranges of temperature. The investigated formulations of liquid consistency at room temperature were obtained in sterile conditions on the basis of nonionic polymers Pluronic F-127, Pluronic F-68 and anionic polymer hyaluronic acid in different concentrations. The sol-gel transition temperature of the formulations was investigated and their physicochemical properties such as pH, density, osmotic pressure, sol-gel transition temperature, texture and release of vancomycin hydrochloride were studied. In vitro release experiments indicated that the optimised platform was able to prolong vancomycin hydrochloride release and their physico-chemical properties allow for application by injection form.
authors.affiliation: Katedra i Zakład Technologii Postaci Leku, Akademia Medyczna we Wrocławiu. bozkar@ktpl.am.wroc.pl
authors.forename: Bozena
authors.initials: B
authors.lastname: Karolewicz
authors.forename: Artur
authors.initials: A
authors.lastname: Owczarek
authors.forename: Janusz
authors.initials: J
authors.lastname: Pluta
mesh_terms: D002626:Chemistry, Pharmaceutical; D005079:Excipients / Q000737:chemistry; D005782:Gels / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007267:Injections; D009994:Osmolar Concentration; D014677:Pharmaceutical Vehicles / Q000737:chemistry*; D020442:Poloxamer / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D013696:Temperature; D014640:Vancomycin / Q000737:chemistry*
chemical_list: D005079:Excipients; D005782:Gels; D014677:Pharmaceutical Vehicles; D011108:Polymers; D020442:Poloxamer; D014640:Vancomycin