title: Th17-related genes and celiac disease susceptibility.
abstract: Th17 cells are known to be involved in several autoimmune or inflammatory diseases. In celiac disease (CD), recent studies suggest an implication of those cells in disease pathogenesis. We aimed at studying the role of genes relevant for the Th17 immune response in CD susceptibility. A total of 101 single nucleotide polymorphisms (SNPs), mainly selected to cover most of the variability present in 16 Th17-related genes (IL23R, RORC, IL6R, IL17A, IL17F, CCR6, IL6, JAK2, TNFSF15, IL23A, IL22, STAT3, TBX21, SOCS3, IL12RB1 and IL17RA), were genotyped in 735 CD patients and 549 ethnically matched healthy controls. Case-control comparisons for each SNP and for the haplotypes resulting from the SNPs studied in each gene were performed using chi-square tests. Gene-gene interactions were also evaluated following different methodological approaches. No significant results emerged after performing the appropriate statistical corrections. Our results seem to discard a relevant role of Th17 cells on CD risk.
authors.affiliation: UGC de Inmunología, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain.
authors.forename: Luz María
authors.initials: LM
authors.lastname: Medrano
authors.forename: Manuel
authors.initials: M
authors.lastname: García-Magariños
authors.forename: Bárbara
authors.initials: B
authors.lastname: Dema
authors.forename: Laura
authors.initials: L
authors.lastname: Espino
authors.forename: Carlos
authors.initials: C
authors.lastname: Maluenda
authors.forename: Isabel
authors.initials: I
authors.lastname: Polanco
authors.forename: M Ángeles
authors.initials: MÁ
authors.lastname: Figueredo
authors.forename: Miguel
authors.initials: M
authors.lastname: Fernández-Arquero
authors.forename: Concepción
authors.initials: C
authors.lastname: Núñez
mesh_terms: D002446:Celiac Disease / Q000209:etiology / Q000235:genetics*; D004843:Epistasis, Genetic; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D058504:Th17 Cells / Q000276:immunology*