title: The identification of high risk pregnancy: a new challenge in obstetrics.
abstract: Preterm delivery (PTD) and pre-eclampsia (PE) represent the main "obstetric syndromes," caused by multiple conditions, and characterized by complex pathogenesis. Nonetheless, recent evidences attest that deregulation of the immune system and exaggeration of inflammatory processes, taking place in the feto-placental unit, represent common central mechanisms occurring in both diseases. Tertiary prevention represents the only intervention to prevent PTD, but its incidence is still increasing. Advances in secondary prevention, focusing on risk factors and possible markers, are necessary.
authors.affiliation: Obstetrics and Gynecology, Department of Pediatrics, Obstetrics and Reproductive Medicine, University of Siena, Siena, Italy.
authors.forename: Michela
authors.initials: M
authors.lastname: Torricelli
authors.forename: Chiara
authors.initials: C
authors.lastname: Voltolini
authors.forename: Maria
authors.initials: M
authors.lastname: De Bonis
authors.forename: Francesca Letizia
authors.initials: FL
authors.lastname: Vellucci
authors.forename: Nathalie
authors.initials: N
authors.lastname: Conti
authors.forename: Filiberto Maria
authors.initials: FM
authors.lastname: Severi
authors.forename: Felice
authors.initials: F
authors.lastname: Petraglia
mesh_terms: D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D009774:Obstetrics / Q000639:trends; D011225:Pre-Eclampsia / Q000097:blood / Q000453:epidemiology / Q000517:prevention & control*; D011247:Pregnancy; D047928:Premature Birth / Q000097:blood / Q000453:epidemiology / Q000517:prevention & control*
chemical_list: D015415:Biomarkers