title: Expansion of human autologous cytotoxic T lymphocytes on fixed target tumor cells.
abstract: Human tumor specific cytotoxic T lymphocytes (CTL) were expanded on formalin-fixed autologous target tumor cells derived from glioblastoma multiforme. Growth response of the CTL restimulated with the fixed target cells was larger than those with live target cells. The results suggest that formalin-fixed tumor cells will be stable sources of tumor antigen for efficient autologous CTL expansion and be useful for adoptive immunotherapy of tumors.
authors.affiliation: RIKEN Cell Bank, The Institute of Physical and Chemical Research (RIKEN) Institute of Applied Biochemistry, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Horiuchi
authors.forename: H
authors.initials: H
authors.lastname: Tsurushima
authors.forename: B
authors.initials: B
authors.lastname: Soo Kim
authors.forename: S
authors.initials: S
authors.lastname: Qin Liu
authors.forename: K
authors.initials: K
authors.lastname: Saijo
authors.forename: Y
authors.initials: Y
authors.lastname: Saijo
authors.forename: T
authors.initials: T
authors.lastname: Nukiwa
authors.forename: N
authors.initials: N
authors.lastname: Nomura
authors.forename: M
authors.initials: M
authors.lastname: Matsumura
authors.forename: T
authors.initials: T
authors.lastname: Ohno