title: Enantioselective disposition of omeprazole, pantoprazole, and lansoprazole in a same Brazilian subjects group.
abstract: This work reports the result of the enantioselective disposition of pantoprazole, omeprazole, and lansoprazole in a same group of Brazilian health subjects. Ten nongenotyped healthy subjects were used for this study. Each subject received a single oral dose of 80 mg of pantoprazole, 40 mg of omeprazole, and 30 mg of lansoprazole, and the plasma concentrations of the enantiomers were measured for 8 h postdose. For pantoprazole and omeprazole, among the 10 volunteers investigated, only one volunteer (Subject # 4) presented higher plasma concentrations of the (+)-enantiomer than those of (-)-enantiomer. Nevertheless, the area under the concentration-time curve of the (+)-lansoprazole was higher than those the (-)-lansoprazole for all subjects. The comparison of proton pump inhibitors' enantiomers disposition from a single group volunteer demonstrated that pantoprazole and omeprazole can be used to differentiate extensive from poor CYP2C19 metabolizer while lansoprazole cannot do it.
authors.affiliation: Departamento de Química, Universidade Federal de São Carlos, São Carlos, São Paulo, Brazil.
authors.forename: Neila M
authors.initials: NM
authors.lastname: Cassiano
authors.forename: Regina V
authors.initials: RV
authors.lastname: Oliveira
authors.forename: Gilberto C R
authors.initials: GC
authors.lastname: Bernasconi
authors.forename: Quezia B
authors.initials: QB
authors.lastname: Cass
mesh_terms: D053799:2-Pyridinylmethylsulfinylbenzimidazoles / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics; D000293:Adolescent; D000328:Adult; D001938:Brazil; D006801:Humans; D064747:Lansoprazole; D008875:Middle Aged; D009853:Omeprazole / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics; D000077402:Pantoprazole; D054328:Proton Pump Inhibitors / Q000097:blood / Q000737:chemistry* / Q000493:pharmacokinetics*; D013237:Stereoisomerism; D013379:Substrate Specificity; D055815:Young Adult
chemical_list: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D054328:Proton Pump Inhibitors; D064747:Lansoprazole; D000077402:Pantoprazole; D009853:Omeprazole