title: Toxic epidermal necrolysis associated with sorafenib and tosufloxacin in a patient with hepatocellular carcinoma.
abstract: This is the first case report to describe a 44-year-old woman with a history of advanced hepatocellular carcinoma who developed toxic epidermal necrolysis (TEN) clinically after taking 400 mg sorafenib (Nexavar®, BAY 43-9006) and tosufloxacin orally once per day. Both sorafenib and tosufloxacin were eventually discontinued, and the TEN resolved with corticosteroids and supportive treatment. Clinical physicians should be aware of this possible complication so that early interventions can be made.
authors.affiliation: Department of Internal Medicine, Pusan National University School of Medicine, Busan, Korea.
authors.forename: Mun Ki
authors.initials: MK
authors.lastname: Choi
authors.forename: Hyun Young
authors.initials: HY
authors.lastname: Woo
authors.forename: Jeong
authors.initials: J
authors.lastname: Heo
authors.forename: Mong
authors.initials: M
authors.lastname: Cho
authors.forename: Gwang Ha
authors.initials: GH
authors.lastname: Kim
authors.forename: Geun Am
authors.initials: GA
authors.lastname: Song
authors.forename: Moon Bum
authors.initials: MB
authors.lastname: Kim