title: Expression of interferon genes in murine macrophages: Possible role of endogenous interferon in the modulation of cell differentiation.
abstract: The expression of interferon (IFN)-β gene was studied in mouse peritoneal macrophages (PM) harvested from normal mice (lps ( n )) or LPS-hyporesponsive mice (lps ( d )). A strong direct correlation between the LPS response of PM and their capacity to expressing basal levels of IFN was found. The results suggest that the constitutive expression of IFN-β gene can play an important role not only in the resistance to viral infection but also in the modulation of cell differentiation.
authors.affiliation: Laboratory of Virology, Istituto Superiore di Sanità, Viale Regina Elena 299, Rome, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Di Marzio
authors.forename: S
authors.initials: S
authors.lastname: Gessani
authors.forename: L
authors.initials: L
authors.lastname: Conti
authors.forename: P
authors.initials: P
authors.lastname: Borghi
authors.forename: F
authors.initials: F
authors.lastname: Belardelli