title: [Relationship between compliance with inhaled corticosteroids and changes in the fraction of exhaled nitric oxide during summer camp for asthmatic children].
abstract: BACKGROUND
  Recently, the fraction of exhaled nitric oxide (FENO), which can be measured easily and noninvasively even in children, has attracted attention as a method of evaluating airway inflammation. The aim of this study was to investigate the relationship between compliance with inhaled corticosteroids (ICS) before a summer camp for asthmatic children and the changes in the FENO during camp.
  
  
  METHODS
  Fifty asthmatic children (26 boys and 24 girls) aged 6-12 years old were recruited from the Fukuoka National Hospital Summer Camp between 2008 and 2010. We measured their FENO on the first and last day of camp. The children were taught appropriate inhalation methods by pediatric pulmonologists and nurses and performed ICS under their supervision every day during the camp. Before the camp, we asked the participants to complete a questionnaire regarding the use of ICS. The participants were classified into four groups according to their adherence to this therapy. The changes in FENO were then examined and compared among the groups.
  
  
  RESULTS
  The FENO measured on the last day of camp was significantly lower than that measured on the first day of camp among children who tended to forget to perform ICS. However, no significant difference in the FENO measurements were observed during the camp, when the children were performing ICS every day.
  
  
  CONCLUSIONS
  The FENO decreased significantly after only four days of camp in the poor compliance group. Therefore, teaching children the appropriate method for inhaling ICS is important, especially for children who tend to forget to perform ICS.
authors.affiliation: Department of Pediatrics, Fukuoka National Hospital.
authors.forename: Yuko
authors.initials: Y
authors.lastname: Amimoto
authors.forename: Yohei
authors.initials: Y
authors.lastname: Arakaki
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Murakami
authors.forename: Natsuko
authors.initials: N
authors.lastname: Masumoto
authors.forename: Naohiko
authors.initials: N
authors.lastname: Taba
authors.forename: Yoko
authors.initials: Y
authors.lastname: Murakami
authors.forename: Junichiro
authors.initials: J
authors.lastname: Tezuka
authors.forename: Satoshi
authors.initials: S
authors.lastname: Honjo
authors.forename: Chikako
authors.initials: C
authors.lastname: Motomura
authors.forename: Rumiko
authors.initials: R
authors.lastname: Shibata
authors.forename: Kenji
authors.initials: K
authors.lastname: Okada
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Odajima
mesh_terms: D000280:Administration, Inhalation; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D001944:Breath Tests; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D009569:Nitric Oxide / Q000032:analysis*; D010349:Patient Compliance
chemical_list: D000305:Adrenal Cortex Hormones; D009569:Nitric Oxide