title: [Predictive study of HBsAg in different stages of neonatal venous blood on failure of blocking HBV mother to infant transmission].
abstract: OBJECTIVE
  In this study, we discuss the predictive value of different content of HBsAg in different stages of neotal venous blood on failure of blocking mother to infant transmission of HBV.
  
  
  METHODS
  150 infants born of chronically HBV infected mothers who were positive of both HBsAg and HBeAg and who also had a HBV DNA virus load above 10(5) copies/ml were enrolled. These infants were given hepatitis B virus immune globin (HBIG) 200 IU immediately after birth and were given hepatitis B vaccine 10 or 20 microg at brith, 1 month and 6 months after birth. HBV serological index of these infants were test at birth, 1 month and 7 months after birth respectively. Different content of HBsAg in different stages of neonatal venus blood were analyzed to predict the failure of blocking mother to infant transmission of HBV.
  
  
  RESULTS
  11 infants failed in blocking of HBV mother to infant transmission. The positive rate of HBsAg at birth, 1 month and 7 months after birth were 41.26%, 10.49% and 7.69% respectively, and were 97.90%, 65.73% and 13.29% of HBeAg. The positive predictive value of HBsAg > or = 0.05 and HBsAg > or = 1 IU/ml at birth were 18.64% and 70% respectively, and were 73.33% and 100% one month after birth.
  
  
  CONCLUSIONS
  Infants with HBsAg > or = 1 IU/ml at birth should be suspicious of failure on blocking HBV mother-to-infant transmission and it should be more credible if the infant has HBsAg > or = 1 IU/ml one month after birth. How to improve the blocking rate of neonates who were positive of HBsAg at birth and one month after birth should be the focus of our future research.
authors.affiliation: Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Yi
authors.forename: Ming-Hui
authors.initials: MH
authors.lastname: Li
authors.forename: Yu-Hong
authors.initials: YH
authors.lastname: Hu
authors.forename: Feng
authors.initials: F
authors.lastname: Liu
authors.forename: Yang-Li
authors.initials: YL
authors.lastname: Zhang
authors.forename: Xue-Jing
authors.initials: XJ
authors.lastname: Liu
authors.forename: Hong-Xiao
authors.initials: HX
authors.lastname: Hao
authors.forename: Shu-Jing
authors.initials: SJ
authors.lastname: Song
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Xing-Hong
authors.initials: XH
authors.lastname: Li
authors.forename: Ji-Yun
authors.initials: JY
authors.lastname: Sun
authors.forename: Min
authors.initials: M
authors.lastname: Liu
authors.forename: Jun
authors.initials: J
authors.lastname: Cheng
authors.forename: Yao
authors.initials: Y
authors.lastname: Xie
mesh_terms: D000328:Adult; D005260:Female; D006509:Hepatitis B / Q000097:blood / Q000517:prevention & control* / Q000635:transmission* / Q000821:virology; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D017325:Hepatitis B Vaccines / Q000008:administration & dosage; D006515:Hepatitis B virus / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000097:blood / Q000517:prevention & control* / Q000821:virology; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D008297:Male; D009035:Mothers; D011237:Predictive Value of Tests; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood / Q000821:virology*; D055815:Young Adult
chemical_list: D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines