title: Ameliorating effect of selenium on chromium (VI)-induced oxidative damage in the brain of adult rats.
abstract: Chromium is known for its wide toxic manifestations. This experiment aims to evaluate the effect of selenium against oxidative stress induced by chromium in the cerebrum and cerebellum. Female Wistar rats were randomly divided into four groups of six each: group I served as controls which received the standard diet; group II received drinking water K(2)Cr(2)O(7) alone (700 ppm); group III received both K(2)Cr(2)O(7) and Se (0.5 mg Na(2)SeO(3)/kg of diet); and group IV received Se (0.5 mg/kg of diet) for 3 weeks. The exposure of rats to K(2)Cr(2)O(7) promoted oxidative stress in the cerebrum and cerebellum with an increase in malondialdehyde and a decrease of nonenzymatic antioxidant levels such as glutathione, nonprotein thiol, and vitamin C. An increase of enzyme activities like catalase, glutathione peroxidase, and superoxide dismutase activities was also observed. Acetylcholinesterase activity was inhibited after treatment with K(2)Cr(2)O(7). Co-administration of Se restored the parameters cited above. The histopathological findings confirmed the biochemical results.
authors.affiliation: Animal Physiology Laboratory UR/08-73, Faculty of Sciences, University of Sfax, BP1171, 3000 Sfax, Tunisia.
authors.forename: Nejla
authors.initials: N
authors.lastname: Soudani
authors.forename: Afef
authors.initials: A
authors.lastname: Troudi
authors.forename: Ibtissem Ben
authors.initials: IB
authors.lastname: Amara
authors.forename: Hanen
authors.initials: H
authors.lastname: Bouaziz
authors.forename: Tahia
authors.initials: T
authors.lastname: Boudawara
authors.forename: Najiba
authors.initials: N
authors.lastname: Zeghal
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000378:metabolism; D001921:Brain / Q000187:drug effects* / Q000378:metabolism*; D002531:Cerebellum / Q000187:drug effects / Q000378:metabolism; D054022:Cerebrum / Q000187:drug effects / Q000378:metabolism; D005260:Female; D015227:Lipid Peroxidation; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D011192:Potassium Dichromate / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D012643:Selenium; D001205:Ascorbic Acid; D011192:Potassium Dichromate