title: Monoaminergic signaling as a target for anthelmintic drug discovery: receptor conservation among the free-living and parasitic nematodes.
abstract: This review is designed to summarize the information on monoamine-dependent paralysis as a target for anthelmintic development, examine the conservation of monoamine receptors in the genomes of both free-living and parasitic nematodes, and highlight the utility of the Caenorhabditis elegans model system for dissecting the monoaminergic modulation of locomotory decision-making.
authors.affiliation: Department of Biological Sciences, The University of Toledo, Toledo, OH 43606, United States. rkomuni@uoft02.utoledo.edu
authors.forename: Richard
authors.initials: R
authors.lastname: Komuniecki
authors.forename: Wen Jing
authors.initials: WJ
authors.lastname: Law
authors.forename: Aaron
authors.initials: A
authors.lastname: Jex
authors.forename: Peter
authors.initials: P
authors.lastname: Geldhof
authors.forename: John
authors.initials: J
authors.lastname: Gray
authors.forename: Bruce
authors.initials: B
authors.lastname: Bamber
authors.forename: Robin B
authors.initials: RB
authors.lastname: Gasser
mesh_terms: D000588:Amines / Q000494:pharmacology*; D000818:Animals; D000969:Antinematodal Agents / Q000494:pharmacology* / Q000627:therapeutic use; D055808:Drug Discovery; D015801:Helminth Proteins / Q000819:agonists / Q000235:genetics / Q000378:metabolism; D006801:Humans; D009348:Nematoda / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism*; D009349:Nematode Infections / Q000188:drug therapy; D058974:Phylogeography; D011956:Receptors, Cell Surface / Q000819:agonists / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D000588:Amines; D000969:Antinematodal Agents; D015801:Helminth Proteins; D011956:Receptors, Cell Surface