title: Management of neonatal thrombosis.
abstract: Neonates have one of the highest risks for thromboembolism among pediatric patients. This risk is attributable to a combination of multiple genetic and acquired risk factors. Despite a significant number of these events being either life threatening or limb threatening, there is limited evidence on appropriate management strategy. Most of what is recommended is based on uncontrolled studies, case series, or expert opinion. This review begins with a discussion of the neonatal hemostatic system, focusing on the common sites and imaging modalities for the detection of neonatal thrombosis. Perinatal and postnatal risk factors are presented and management options discussed.
authors.affiliation: Pediatrix Medical Group, Jeff Gordon Children's Hospital, 920 Church Street North, CMC-NE, Concord, NC 28025, USA. Matthew_saxonhouse@pediatrix.com
authors.forename: Matthew A
authors.initials: MA
authors.lastname: Saxonhouse
mesh_terms: D003937:Diagnosis, Differential; D003952:Diagnostic Imaging; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D008866:Microsurgery; D005996:Nitroglycerin / Q000627:therapeutic use; D012307:Risk Factors; D015912:Thrombolytic Therapy / Q000379:methods; D013927:Thrombosis / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy*; D014665:Vasodilator Agents / Q000627:therapeutic use
chemical_list: D014665:Vasodilator Agents; D006493:Heparin; D005996:Nitroglycerin