title: Adiponectin and interleukin-6 levels in insulin-treated diabetic rats with experimental periodontitis.
abstract: The aim of the study was to compare the serum levels of adiponectin and interleukin-6 (IL-6) in insulin-treated diabetic rats with or without periodontitis. Forty male Wistar rats were randomly divided into 2 groups (20 rats each): a) insulin-treated diabetic group (control, DI) and b) insulin-treated diabetic periodontitis group (test, DIP). Diabetes was induced, and insulin treatment was initiated on day 5. On day 16, periodontitis was induced in the DIP group. All rats were euthanized on day 77. Adiponectin and IL-6 were assessed on days 16 and 77. At the end of the experiment, 14 and 11 rats survived in the DI and DIP groups, respectively. Adiponectin levels were statistically significantly higher at the end of the experiment compared with levels on day 16 in the periodontitis group (p < 0.05), but not in the control group. At the end of the experiment, adiponectin levels were statistically significantly higher in the periodontitis group compared with the control group (p < 0.05). Within-group and between-group comparisons of IL-6 levels showed no statistically significant difference. In conclusion, serum adiponectin was increased in insulin-treated diabetic rats with periodontitis in comparison with insulin-treated diabetic rats, while IL-6 levels did not differ between groups.
authors.affiliation: Department of Periodontology, School of Dentistry, University of Athens, Athens, Greece. yanna_x77@hotmail.com
authors.forename: Ioanna
authors.initials: I
authors.lastname: Xynogala
authors.forename: Eudoxie
authors.initials: E
authors.lastname: Pepelassi
authors.forename: Despina
authors.initials: D
authors.lastname: Perrea
authors.forename: George
authors.initials: G
authors.lastname: Agrogiannis
authors.forename: Alkistis
authors.initials: A
authors.lastname: Pantopoulou
authors.forename: Efstratios
authors.initials: E
authors.lastname: Patsouris
authors.forename: Ioannis
authors.initials: I
authors.lastname: Vrotsos
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000818:Animals; D001786:Blood Glucose; D003920:Diabetes Mellitus / Q000097:blood* / Q000188:drug therapy; D004195:Disease Models, Animal; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000627:therapeutic use*; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D010518:Periodontitis / Q000097:blood* / Q000139:chemically induced; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D015850:Interleukin-6