title: Dexamethasone therapy for bacterial meningitis: Better never than late?
abstract: A multicentre randomized controlled trial was conducted in children with bacterial meningitis using dexamethasone or placebo for four days within 24 h of starting antibiotics. Primary outcomes were hearing loss and neurological abnormalities at 12 months after meningitis. The dexamethasone (n=50) and placebo (n=51) groups were similar in age, severity of illness and etiological agent. Hearing loss occurred in 10% and 11% of the dexamethasone and placebo groups and neurological deficits occurred in 20% and 18% of patients, respectively. Duodenal perforation occurred in one dexamethasone-treated child. In conclusion, there was no significant benefit in those receiving dexamethasone. The lack of benefit may have been due to the delay in administration of dexamethasone (median delay of 11 h after antibiotics). Therefore, if dexamethasone is used for meningitis it should be given immediately with the antibiotic.
authors.affiliation: Division of Infectious Disease, Departments of Pediatrics and Audiology, Hospital for Sick Children and University of Toronto, Toronto, Ontario; Division of Infectious Diseases, The Health Sciences Centre, Winnipeg, Manitoba; and Division of Infectious Diseases, The Izaak Walton Killam Hospital, Halifax, Nova Scotia.
authors.forename: S M
authors.initials: SM
authors.lastname: King
authors.forename: B
authors.initials: B
authors.lastname: Law
authors.forename: J M
authors.initials: JM
authors.lastname: Langley
authors.forename: H
authors.initials: H
authors.lastname: Heurter
authors.forename: D
authors.initials: D
authors.lastname: Bremner
authors.forename: E E
authors.initials: EE
authors.lastname: Wang
authors.forename: R
authors.initials: R
authors.lastname: Gold