title: Association between the dexamethasone suppression test and serotonin transporter availability in healthy volunteer: a SPECT with [(123)I] ADAM study.
abstract: Most common psychiatric diseases have been found to be associated with disturbance of both the hypothalamic-pituitary-adrenal (HPA) axis and the brain serotonergic system. The aim of this study was to explore the neuroendocrine relationships between the dexamethasone suppression test (DST) and serotonin transporter (SERT) availability in healthy volunteers. Sixty-six participants (30 males and 36 females) were recruited from the community. The DST suppression rate (D%) is the reduction in cortisol level from Day 1 (D1) to Day 2 (D2) in proportion to the Day 1 cortisol level (D%=(D1-D2)/D1×100%). SPECT with [(123)I] ADAM was used to measure SERT availability. A significant correlation between D% and SERT availability was noted in all subjects (Spearman's ρ=0.26, p=0.03) and in the male subjects (Spearman's ρ=0.41, p=0.02). SERT availability may be sensitive to changes in DST, especially in males.
authors.affiliation: Department of Psychiatry, St. Martin De Porres Hospital, Chiayi, Taiwan.
authors.forename: Hsiang-Yi
authors.initials: HY
authors.lastname: Tsai
authors.forename: I Hui
authors.initials: IH
authors.lastname: Lee
authors.forename: Tzung Lieh
authors.initials: TL
authors.lastname: Yeh
authors.forename: Wei Jen
authors.initials: WJ
authors.lastname: Yao
authors.forename: Kao Chin
authors.initials: KC
authors.lastname: Chen
authors.forename: Po See
authors.initials: PS
authors.lastname: Chen
authors.forename: Nan-Tsing
authors.initials: NT
authors.lastname: Chiu
authors.forename: Ru-Band
authors.initials: RB
authors.lastname: Lu
authors.forename: Yen Kuang
authors.initials: YK
authors.lastname: Yang
mesh_terms: D000328:Adult; D001921:Brain / Q000378:metabolism; D002928:Cinanserin / Q000031:analogs & derivatives*; D003907:Dexamethasone; D005260:Female; D059907:Functional Neuroimaging / Q000379:methods* / Q000706:statistics & numerical data; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D007457:Iodine Radioisotopes; D008297:Male; D010912:Pituitary-Adrenal Function Tests / Q000379:methods* / Q000706:statistics & numerical data; D050486:Serotonin Plasma Membrane Transport Proteins / Q000378:metabolism*; D012727:Sex Characteristics; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods / Q000706:statistics & numerical data
chemical_list: C413491:2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine; D007457:Iodine Radioisotopes; D050486:Serotonin Plasma Membrane Transport Proteins; D003907:Dexamethasone; D002928:Cinanserin; D006854:Hydrocortisone