title: Direct C-H cross-coupling approach to heteroaryl coumarins.
abstract: A Pd-catalyzed direct cross-coupling of 3-bromocoumarins with heteroarenes provided an efficient route to synthesizing 3-heteroarylcoumarins. The reaction scope for the transformation was fairly broad, affording modest to good yields of various 3-heteroarylcoumarin scaffolds, which are privileged structures and prevalent motifs in many biologically active compounds and fluorophores.
authors.affiliation: Department of Chemistry, Korea Advanced Institute of Science and Technology, Daejeon, 305-701, Korea.
authors.forename: Minsik
authors.initials: M
authors.lastname: Min
authors.forename: Bomi
authors.initials: B
authors.lastname: Kim
authors.forename: Sungwoo
authors.initials: S
authors.lastname: Hong
mesh_terms: D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D003374:Coumarins / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry
chemical_list: D003374:Coumarins; D010165:Palladium; D002244:Carbon; D006859:Hydrogen