title: The effect of exenatide and erythromycin on postprandial symptoms and their relation to gastric functions.
abstract: BACKGROUND
  The relationship between abnormal gastric motor function and postprandial abdominal symptoms has not been fully clarified. The aim of the study was to investigate this relationship in response to mediators that affect gastric function.
  
  
  METHODS
  Ten healthy volunteers participated in a 3-way cross-over study of treatment with placebo, exenatide and erythromycin. The studies were performed at 1-week intervals. Each subject underwent 3-dimensional single photon emission computed tomography to measure fasting and postprandial gastric volumes. A combined nutrient drink test and cutaneous electrogastrography (EGG) were performed on the next day.
  
  
  RESULTS
  Erythromycin reduced postprandial symptoms compared with placebo. The postprandial gastric volume after exenatide was greater than after placebo and erythromycin treatment. Exenatide did not aggravate postprandial symptoms compared with placebo. The ratio of postprandial over fasting gastric volume was inversely correlated with the total postprandial symptom score after placebo, exenatide and erythromycin treatment. The postprandial symptom score of the normal EGG group was significantly lower than that of the abnormal group, considering overall treatments.
  
  
  CONCLUSIONS
  Erythromycin reduced postprandial symptoms, whereas exenatide did not aggravate postprandial symptoms, possibly due to its enhancement of gastric accommodation. An abnormal EGG rhythm was associated with postprandial symptoms.
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, The Catholic University of Korea, Seoul, Republic of Korea.
authors.forename: Seung Bae
authors.initials: SB
authors.lastname: Yoon
authors.forename: Myung-Gyu
authors.initials: MG
authors.lastname: Choi
authors.forename: Chul-Hyun
authors.initials: CH
authors.lastname: Lim
authors.forename: Jin Soo
authors.initials: JS
authors.lastname: Kim
authors.forename: Yu Kyung
authors.initials: YK
authors.lastname: Cho
authors.forename: Jae Myung
authors.initials: JM
authors.lastname: Park
authors.forename: In Seok
authors.initials: IS
authors.lastname: Lee
authors.forename: Sang Woo
authors.initials: SW
authors.lastname: Kim
authors.forename: Kyu Yong
authors.initials: KY
authors.lastname: Choi
authors.forename: In-Sik
authors.initials: IS
authors.lastname: Chung
mesh_terms: D000328:Adult; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004576:Electromyography; D004917:Erythromycin / Q000008:administration & dosage*; D000077270:Exenatide; D005260:Female; D005746:Gastric Emptying / Q000502:physiology; D005765:Gastrointestinal Agents / Q000008:administration & dosage*; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage*; D008297:Male; D010455:Peptides / Q000008:administration & dosage*; D019518:Postprandial Period / Q000187:drug effects*; D013270:Stomach / Q000000981:diagnostic imaging / Q000187:drug effects*; D015899:Tomography, Emission-Computed, Single-Photon; D014688:Venoms / Q000008:administration & dosage*; D055815:Young Adult
chemical_list: D005765:Gastrointestinal Agents; D007004:Hypoglycemic Agents; D010455:Peptides; D014688:Venoms; D004917:Erythromycin; D000077270:Exenatide