title: The effects of acute exercise bouts on hepcidin in women.
abstract: OBJECTIVE
  To investigate the effects of acute exercise on serum hepcidin and iron (sFe) in active women. Changes in interleukin-6 (IL-6), hepcidin, ferritin, and sFe in response to 2 different exercise durations were compared.
  
  
  METHODS
  Twelve women age 19-32 yr performed 2 treadmill runs (60 and 120 min) at 65% of VO2max. Blood samples were obtained before, immediately after, and 3, 6, 9, and 24 hr after exercise. Two-way repeated-measures ANOVA was conducted to examine changes in measured variables. Significance was accepted at p < .05.
  
  
  RESULTS
  Significant effects for trial were observed for hepcidin (60 min: 1.15 ± 0.48 nmol/L; 120 min: 2.28 ± 1.44 nmol/L) and for time, with hepcidin significantly increased 3 hr postexercise in both trials (60 min: 3 hr - 1.99 ± 2.00 nmol/L; 120 min: 3 hr - 4.60 ± 4.61 nmol/L). Significant main effects for time occurred for sFe, ferritin, and IL-6. sFe was significantly decreased 9 hr postexercise compared with 3 and 24 hr postexercise. IL-6 was significantly increased immediately postexercise.
  
  
  CONCLUSIONS
  Both runs resulted in significant increases in hepcidin 3 hr after exercise. Increases in hepcidin were preceded by significant increases in IL-6 immediately postexercise and followed by significant decreases in sFe 9 hr postexercise. It was concluded that endurance exercise increases the production of hepcidin, which affects sFe. The 2-hr exercise bout stimulated greater changes in serum hepcidin than the 1-hr bout.
authors.affiliation: Department of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, FL, USA.
authors.forename: Mia K
authors.initials: MK
authors.lastname: Newlin
authors.forename: Sara
authors.initials: S
authors.lastname: Williams
authors.forename: Tim
authors.initials: T
authors.lastname: McNamara
authors.forename: Harold
authors.initials: H
authors.lastname: Tjalsma
authors.forename: Dorine W
authors.initials: DW
authors.lastname: Swinkels
authors.forename: Emily M
authors.initials: EM
authors.lastname: Haymes
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D023181:Antimicrobial Cationic Peptides / Q000097:blood*; D005260:Female; D005293:Ferritins / Q000097:blood; D064451:Hepcidins; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D007501:Iron / Q000097:blood*; D010101:Oxygen Consumption; D010807:Physical Endurance / Q000502:physiology*; D012420:Running / Q000502:physiology*; D013997:Time Factors; D055815:Young Adult
chemical_list: D023181:Antimicrobial Cationic Peptides; C578702:HAMP protein, human; D064451:Hepcidins; D015850:Interleukin-6; D005293:Ferritins; D007501:Iron