title: Tumor suppressor genes on frequently deleted chromosome 3p in nasopharyngeal carcinoma.
abstract: Nasopharyngeal carcinoma (NPC) is among the most common malignancies in southern China. Deletion of genomic DNA, which occurs during the complex pathogenesis process for NPC, represents a pivotal mechanism in the inactivation of tumor suppressor genes (TSGs). In many circumstances, loss of TSGs can be detected as diagnostic and prognostic markers in cancer. The short arm of chromosome 3 (3p) is a frequently deleted chromosomal region in NPC, with 3p21.1-21.2 and 3p25.2-26.1 being the most frequently deleted minimal regions. In recent years, our research group and others have focused on the identification and characterization of novel target TSGs at 3p, such as RASSF1A, BLU, RBMS3, and CHL1, in the development and progression of NPC. In this review, we summarize recent findings of TSGs at 3p and discuss some of these genes in detail. A better understanding of TSGs at 3p will significantly improve our understanding of NPC pathogenesis, diagnosis, and treatment.
authors.affiliation: Department of Clinical Oncology, The University of Hong Kong, Hong Kong, PR China.
authors.forename: Juan
authors.initials: J
authors.lastname: Chen
authors.forename: Li
authors.initials: L
authors.lastname: Fu
authors.forename: Li-Yi
authors.initials: LY
authors.lastname: Zhang
authors.forename: Dora L
authors.initials: DL
authors.lastname: Kwong
authors.forename: Li
authors.initials: L
authors.lastname: Yan
authors.forename: Xin-Yuan
authors.initials: XY
authors.lastname: Guan
mesh_terms: D015815:Cell Adhesion Molecules / Q000235:genetics; D002872:Chromosome Deletion; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D003598:Cytoskeletal Proteins; D044127:Epigenesis, Genetic; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics; D006801:Humans; D009303:Nasopharyngeal Neoplasms / Q000235:genetics*; D016601:RNA-Binding Proteins / Q000235:genetics; D015534:Trans-Activators / Q000235:genetics; D015293:Transducin; D025521:Tumor Suppressor Proteins / Q000235:genetics*
chemical_list: C490650:CHL1 protein, human; D015815:Cell Adhesion Molecules; D003598:Cytoskeletal Proteins; C034809:GNAT1 protein, human; C411762:RASSF1 protein, human; C405932:RBMS3 protein, human; D016601:RNA-Binding Proteins; D015534:Trans-Activators; D025521:Tumor Suppressor Proteins; C472720:ZMYND10 protein, human; D020962:Heterotrimeric GTP-Binding Proteins; D015293:Transducin