title: Unification of anion relay chemistry with the Takeda and Hiyama cross-coupling reactions: identification of an effective silicon-based transfer agent.
abstract: The unification of Anion Relay Chemistry (ARC) with the Takeda and Hiyama palladium-mediated cross-coupling processes to provide aryl-aryl, alkenyl-aryl, and alkenyl-alkenyl coupled products by exploiting a common silicon-based transfer agent has been achieved. These results provide a practical solution for intermolecular cross-coupling of organolithium reagents without the problematic lithium-halogen exchange and/or undesired homocoupling that has kept organolithium cross-couplings from achieving the same level of utility asother palladium-mediated methods (e.g., Suzuki organoboron, Negishi organozinc, Stille organotin, Kumada organomagnesium, etc.).
authors.affiliation: Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19128, United States. smithab@sas.upenn.edu
authors.forename: Amos B
authors.initials: AB
authors.lastname: Smith
authors.forename: Adam T
authors.initials: AT
authors.lastname: Hoye
authors.forename: Dionicio
authors.initials: D
authors.lastname: Martinez-Solorio
authors.forename: Won-Suk
authors.initials: WS
authors.lastname: Kim
authors.forename: Rongbiao
authors.initials: R
authors.lastname: Tong
mesh_terms: D000838:Anions / Q000737:chemistry*; D012825:Silicon / Q000737:chemistry*
chemical_list: D000838:Anions; D012825:Silicon