title: Dental caries recurrence following clinical treatment for severe early childhood caries.
abstract: OBJECTIVE
  To determine the relapse rate within one year for a cohort of children treated for severe early childhood caries (S-ECC).
  
  
  METHODS
  In an earlier report, we assessed the suppressive effect of 10 percent povidone-iodine and the elimination of active caries on salivary  mutans streptococci (MS) populations in 77 children with S-ECC; 49 children returned for a 6-month recall exam that occurred 5 to 12 months post dental surgery. Relapse declaration required at least one caries lesion needing a restoration. Contrasts of relapse (R) and non-relapse (NR) to the  covariates of gender, race, ethnicity, age, surfaces available for relapse (SAR), time to appointment, and baseline salivary mutans streptococci (MS) counts were statistically evaluated.
  
  
  RESULTS
  19 children (39%) were declared R and 30 (61%) were NR. The 2 groups did not statistically  differ on: gender, race, ethnicity, age, SAR, baseline salivary MS counts and time to recall appointment. Statistical analyses also showed the covariates had no significant effect on probability of relapse or time to relapse (P>0.05).
  
  
  CONCLUSIONS
  None of the covariates were related  to R. The R rate (39%) observed is consistent with earlier reports. Novel approaches are needed to improve relapse prevention.
authors.affiliation: Department of Dentistry, School of Medicine and Dentistry, the University of Rochester Medical Center, Rochester, NY, USA. robert_berkowitz@urmc.rochester.edu
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Berkowitz
authors.forename: Alvin
authors.initials: A
authors.lastname: Amante
authors.forename: Dorota T
authors.initials: DT
authors.lastname: Kopycka-Kedzierawski
authors.forename: Ronald J
authors.initials: RJ
authors.lastname: Billings
authors.forename: Changyong
authors.initials: C
authors.lastname: Feng
mesh_terms: D000149:Acidulated Phosphate Fluoride / Q000627:therapeutic use; D000367:Age Factors; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use; D058491:Bacterial Load; D002327:Cariostatic Agents / Q000627:therapeutic use; D002675:Child, Preschool; D015331:Cohort Studies; D003731:Dental Caries / Q000209:etiology* / Q000628:therapy; D003793:Dental Restoration, Permanent; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006630:Hispanic or Latino; D006801:Humans; D008297:Male; D009910:Oral Hygiene; D011206:Povidone-Iodine / Q000627:therapeutic use; D011336:Probability; D012008:Recurrence; D012189:Retrospective Studies; D012463:Saliva / Q000382:microbiology; D012737:Sex Factors; D013295:Streptococcus mutans / Q000187:drug effects; D044465:White People
chemical_list: D000891:Anti-Infective Agents, Local; D002327:Cariostatic Agents; D000149:Acidulated Phosphate Fluoride; D011206:Povidone-Iodine