title: Intravenous ferric carboxymaltose accelerates erythropoietic recovery from experimental malarial anemia.
abstract: Iron restriction has been proposed as a cause of erythropoietic suppression in malarial anemia; however, the role of iron in malaria remains controversial, because it may increase parasitemia. To investigate the role of iron-restricted erythropoiesis, A/J mice were infected with Plasmodium chabaudi AS, treated with intravenous ferric carboxymaltose at different times, and compared with untreated controls. Iron treatment significantly increased weight and hemoglobin nadirs and provided enhanced reticulocytosis and faster recovery, compared with controls. Our findings challenge the restrictive use of iron therapy in malaria and show the need for trials of intravenous ferric carboxymaltose as an adjunctive treatment for severe malarial anemia.
authors.affiliation: Centre for Medical Parasitology, Department of Clinical Microbiology, Copenhagen University Hospital (Rigshospitalet), University of Copenhagen, Copenhagen, Denmark.
authors.forename: Lasse
authors.initials: L
authors.lastname: Maretty
authors.forename: Rebecca Emilie
authors.initials: RE
authors.lastname: Sharp
authors.forename: Mikael
authors.initials: M
authors.lastname: Andersson
authors.forename: Jørgen A L
authors.initials: JA
authors.lastname: Kurtzhals
mesh_terms: D018798:Anemia, Iron-Deficiency / Q000188:drug therapy*; D000818:Animals; D004195:Disease Models, Animal; D004920:Erythropoiesis / Q000187:drug effects*; D005290:Ferric Compounds / Q000008:administration & dosage*; D006133:Growth Substances / Q000008:administration & dosage*; D008288:Malaria / Q000150:complications* / Q000469:parasitology; D008297:Male; D008320:Maltose / Q000008:administration & dosage / Q000031:analogs & derivatives*; D051379:Mice; D008805:Mice, Inbred A; D016788:Plasmodium chabaudi / Q000472:pathogenicity; D016896:Treatment Outcome
chemical_list: D005290:Ferric Compounds; D006133:Growth Substances; C522335:ferric carboxymaltose; D008320:Maltose