title: Glycine decarboxylase cleaves a "malignant" metabolic path to promote tumor initiation.
abstract: Tumor-initiating cells (TICs) are thought to be critical for promoting tumorigenesis. In a recent Cell article, Zhang and colleagues found that non-small cell lung cancer TICs overexpress the metabolic enzyme glycine decarboxylase, which leads to increases in pyrimidine synthesis and is critical for proliferation and tumor initiation.
authors.affiliation: Department of Cancer Biology, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: John E
authors.initials: JE
authors.lastname: Dominy
authors.forename: Francisca
authors.initials: F
authors.lastname: Vazquez
authors.forename: Pere
authors.initials: P
authors.lastname: Puigserver