title: An insight into the new anticonvulsant agents.
abstract: The use of current antiepileptic drugs has been questioned due to the nonselectivity of the drugs and the undesirable side effects posed by them. This led to an intensive investigation in this area worldwide during the past 10 years. There have been some significant outcomes and the findings are promising as far as drug efficacy and safety is concerned. This review covers the new anticonvulsant agents that have shown encouraging activities and less neurotoxicity. A detailed pharmacology and pathophysiology of different types of epilepsy is described here with the structural classification of most active agents. The new structural classes of compounds may prove as lead molecules and good candidates for the future investigations.
authors.affiliation: Department of Pharmaceutical Chemistry, College of Pharmacy, Jazan University, Jazan, KSA.
authors.forename: Waquar
authors.initials: W
authors.lastname: Ahsan
authors.forename: Mohsin M
authors.initials: MM
authors.lastname: Safhi
authors.forename: Nadeem
authors.initials: N
authors.lastname: Siddiqui
authors.forename: Shamama
authors.initials: S
authors.lastname: Javed
authors.forename: M Shamsher
authors.initials: MS
authors.lastname: Alam
authors.forename: Bishmillah
authors.initials: B
authors.lastname: Azad
authors.forename: Jawaid
authors.initials: J
authors.lastname: Akhtar
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*; D004827:Epilepsy / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D015394:Molecular Structure
chemical_list: D000927:Anticonvulsants