title: Photodynamic therapy can improve warts' discomfort in renal transplant patients prospective multicenter study.
abstract: Many studies have been conducted showing that aminolevulinic acid (ALA)-photodynamic therapy (PDT) can be an alternative treatment for recalcitrant warts. Recently, we performed a study evaluating methyl-aminolevulinic acid (MAL)-PDT for the treatment of hand warts in a population of renal transplant patients. Two symmetrical targets were selected on each hand and randomly assigned to chemical keratolytic treatment followed by three cycles of ALA-PDT (75 J cm(-2) red light). Patients were evaluated after 3 months and a second run of PDT was performed if the total area and number of warts decreased less than 50%, with evaluation every 3 months for 1 year. Twenty patients were included and 16 were evaluable (9 M, 7 F). After 6 months the reduction of warts' area was 48.4% on the treated side versus 18.4% in the control area (P = 0.021). The decrease in the total number of warts was 41%versus 19.4% (P = NS). The global tolerance of the treatment was good with acceptable pain during irradiation. These results suggest that ALA-PDT is a safe and efficient treatment for transplanted patient warts. The improvement between treated and control zone is 20% due to the decrease in untreated warts' area and number.
authors.affiliation: Department of Dermatology and Venereology, University Hospital, Limoges, France. a.sparsa@free.fr
authors.forename: Agnès
authors.initials: A
authors.lastname: Sparsa
authors.forename: Sophie
authors.initials: S
authors.lastname: Blaise
authors.forename: Brigitte
authors.initials: B
authors.lastname: Tack
authors.forename: François
authors.initials: F
authors.lastname: Dalmay
authors.forename: Dominique
authors.initials: D
authors.lastname: Leroy
authors.forename: Jean-Marie
authors.initials: JM
authors.lastname: Bonnetblanc
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Béani
authors.forename: Christophe
authors.initials: C
authors.lastname: Bédane
mesh_terms: D000328:Adult; D000622:Aminolevulinic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives*; D005260:Female; D006225:Hand / Q000821:virology; D006801:Humans; D016867:Immunocompromised Host; D016030:Kidney Transplantation / Q000276:immunology*; D008027:Light; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000008:administration & dosage*; D011446:Prospective Studies; D016896:Treatment Outcome; D014860:Warts / Q000188:drug therapy* / Q000276:immunology / Q000821:virology
chemical_list: D017319:Photosensitizing Agents; C475457:methyl 5-aminolevulinate; D000622:Aminolevulinic Acid