title: Acute generalized exanthematous pustulosis-like, folliculitic drug reaction pattern caused by celecoxib.
abstract: An extensive range of diseases or reactions can cause pustular eruptions of the skin. Drug-provoked cutaneous eruptions includes acute generalized exanthematous pustulosis (AGEP) and acneiform eruption. We report a 50-year-old man who developed fever and a sudden eruption of widespread pustules 12 days after ingestion of celecoxib prescribed for a prolapsed intervertebral disc. AGEP was diagnosed based on the typical history, characteristic features, and laboratory findings. However, histopathological findings were consistent with folliculitic drug reaction pattern without features of AGEP. We present, the first known reported case of folliculitic drug reaction pattern caused by celecoxib.
authors.affiliation: Departments of Medicine and Pathology, National University Hospital, Singapore. janthorn_pakdeethai@nuhs.edu.sg
authors.forename: Janthorn
authors.initials: J
authors.lastname: Pakdeethai
authors.forename: Sue-Ann
authors.initials: SA
authors.lastname: Ho
authors.forename: Derrick
authors.initials: D
authors.lastname: Aw
authors.forename: Kong Bing
authors.initials: KB
authors.lastname: Tan
mesh_terms: D056150:Acute Generalized Exanthematous Pustulosis / Q000139:chemically induced*; D000068579:Celecoxib; D052246:Cyclooxygenase 2 Inhibitors / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology*; D005499:Folliculitis / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011720:Pyrazoles / Q000009:adverse effects*; D013449:Sulfonamides / Q000009:adverse effects*
chemical_list: D052246:Cyclooxygenase 2 Inhibitors; D011720:Pyrazoles; D013449:Sulfonamides; D000068579:Celecoxib