title: Is subclinical hypothyroidism contributing dyslipidemia and insulin resistance in women with polycystic ovary syndrome?
abstract: We aimed to analyze lipid parameters and determine the need for a 2-hour oral glucose tolerance test (OGTT) for the identification of IR and impaired glucose tolerance test (IGT) in subclinical hypothyroidism (SCH) women with and without polycystic ovary syndrome (PCOS). 20 patients with PCOS and SCH consisted of Group I and 39 patients with PCOS and normal thyroid function consisted of Group II and 53 healthy women with normal thyroid function consisted of Group III. Triglyceride levels were 143.26 ± 99.86 mg/dL in group 1 and 88.56 ± 37.56 mg/dL in group 2 and 83.71 ± 31.94 mg/dL in group 3 which were statistically significant. Total cholesterol, HDL- cholesterol, LDL-cholesterol were found similar between the groups. Fasting insulin levels were 12.45 ± 8.62 µU/mL in group 1 and 8.60 ± 5.35 µU/mL in group 2 and 7.04 ± 3.55 µU/mL in group 3 which were statistically significant (P = 0.027). HOMA-IR were 2.92 ± 2.34 in group 1 and 1.95 ± 1.52 in group 2 and 1.60 ± 0.86 in group 3 which were statistically significant (P = 0.046). This study showed that women with PCOS and subclinical hypothyroidism should be evaluated for dyslipidemia and insulin resistance.
authors.affiliation: Namik Kemal University Medical Faculty, Obstetrics and Gynecology Department, Tekirdag, Turkey.
authors.forename: Cem
authors.initials: C
authors.lastname: Celik
authors.forename: Remzi
authors.initials: R
authors.lastname: Abali
authors.forename: Nicel
authors.initials: N
authors.lastname: Tasdemir
authors.forename: Savas
authors.initials: S
authors.lastname: Guzel
authors.forename: Aytac
authors.initials: A
authors.lastname: Yuksel
authors.forename: Erson
authors.initials: E
authors.lastname: Aksu
authors.forename: Murat
authors.initials: M
authors.lastname: Yılmaz
mesh_terms: D000328:Adult; D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D050171:Dyslipidemias / Q000209:etiology*; D005260:Female; D018149:Glucose Intolerance / Q000209:etiology; D005951:Glucose Tolerance Test; D006801:Humans; D006937:Hypercholesterolemia / Q000209:etiology; D006946:Hyperinsulinism / Q000209:etiology; D015228:Hypertriglyceridemia / Q000209:etiology; D007037:Hypothyroidism / Q000097:blood / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology*; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D009765:Obesity / Q000150:complications; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications / Q000378:metabolism* / Q000503:physiopathology*; D012720:Severity of Illness Index; D014280:Triglycerides / Q000097:blood; D014421:Turkey; D055815:Young Adult
chemical_list: D007328:Insulin; D014280:Triglycerides; D002784:Cholesterol