title: Dibenzocyclooctadiene lignans from Kadsura polysperma and their antineurodegenerative activities.
abstract: Eleven new dibenzocyclooctadiene lignans, polysperlignans A-K (1-11), and eight known analogues (12-19) were isolated from the stems of Kadsura polysperma. Their structures and absolute configurations were established using a combination of MS, NMR, CD, and single-crystal X-ray diffraction techniques. Selected compounds were evaluated for activity against β-amyloid- or hydrogen peroxide-induced neurotoxicity on PC12 cells, and 1, 2, 4, 5, 13, and 16 showed statistically significant neuroprotective effects in these in vitro assays.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.
authors.forename: Ke
authors.initials: K
authors.lastname: Dong
authors.forename: Jian-Xin
authors.initials: JX
authors.lastname: Pu
authors.forename: Hai-Yan
authors.initials: HY
authors.lastname: Zhang
authors.forename: Xue
authors.initials: X
authors.lastname: Du
authors.forename: Xiao-Nian
authors.initials: XN
authors.lastname: Li
authors.forename: Juan
authors.initials: J
authors.lastname: Zou
authors.forename: Jian-Hong
authors.initials: JH
authors.lastname: Yang
authors.forename: Wei
authors.initials: W
authors.lastname: Zhao
authors.forename: Xi-Can
authors.initials: XC
authors.lastname: Tang
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
mesh_terms: D000818:Animals; D018360:Crystallography, X-Ray; D034242:Cyclooctanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006861:Hydrogen Peroxide / Q000494:pharmacology; D032135:Kadsura / Q000737:chemistry*; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008968:Molecular Conformation; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019906:Nuclear Magnetic Resonance, Biomolecular; D018547:Plant Stems / Q000737:chemistry; D051381:Rats
chemical_list: D034242:Cyclooctanes; D004365:Drugs, Chinese Herbal; D017705:Lignans; D018696:Neuroprotective Agents; C510994:dibenzocyclooctadiene lignan; D006861:Hydrogen Peroxide