title: Phosphorylated α-synuclein in Parkinson's disease.
abstract: Phosphorylated α-synuclein (PS-129), a protein implicated in the pathogenesis of Parkinson's disease (PD), was identified by mass spectrometry in human cerebrospinal fluid (CSF). A highly sensitive and specific assay was established and used to measure PS-129 together with total α-synuclein in the CSF of patients with PD, other parkinsonian disorders such as multiple system atrophy (MSA) and progressive supranuclear palsy (PSP), and healthy individuals (a total of ~600 samples). PS-129 CSF concentrations correlated weakly with PD severity and, when combined with total α-synuclein concentrations in CSF, contributed to distinguishing PD from MSA and PSP. Further rigorous validation in independent cohorts of patients, especially those where samples have been collected longitudinally, will determine whether the concentration of PS-129 in CSF will be useful for diagnosing PD and for monitoring PD severity and progression.
authors.affiliation: Department of Pathology, University of Washington School of Medicine, Seattle, WA 98104, USA.
authors.forename: Yu
authors.initials: Y
authors.lastname: Wang
authors.forename: Min
authors.initials: M
authors.lastname: Shi
authors.forename: Kathryn A
authors.initials: KA
authors.lastname: Chung
authors.forename: Cyrus P
authors.initials: CP
authors.lastname: Zabetian
authors.forename: James B
authors.initials: JB
authors.lastname: Leverenz
authors.forename: Daniela
authors.initials: D
authors.lastname: Berg
authors.forename: Karin
authors.initials: K
authors.lastname: Srulijes
authors.forename: John Q
authors.initials: JQ
authors.lastname: Trojanowski
authors.forename: Virginia M-Y
authors.initials: VM
authors.lastname: Lee
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Siderowf
authors.forename: Howard
authors.initials: H
authors.lastname: Hurtig
authors.forename: Irene
authors.initials: I
authors.lastname: Litvan
authors.forename: Mya C
authors.initials: MC
authors.lastname: Schiess
authors.forename: Elaine R
authors.initials: ER
authors.lastname: Peskind
authors.forename: Masami
authors.initials: M
authors.lastname: Masuda
authors.forename: Masato
authors.initials: M
authors.lastname: Hasegawa
authors.forename: Xiangmin
authors.initials: X
authors.lastname: Lin
authors.forename: Catherine
authors.initials: C
authors.lastname: Pan
authors.forename: Douglas
authors.initials: D
authors.lastname: Galasko
authors.forename: David S
authors.initials: DS
authors.lastname: Goldstein
authors.forename: Poul Henning
authors.initials: PH
authors.lastname: Jensen
authors.forename: Hui
authors.initials: H
authors.lastname: Yang
authors.forename: Kevin C
authors.initials: KC
authors.lastname: Cain
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
mesh_terms: D016022:Case-Control Studies; D006801:Humans; D010300:Parkinson Disease / Q000134:cerebrospinal fluid / Q000378:metabolism*; D010766:Phosphorylation; D051844:alpha-Synuclein / Q000378:metabolism*
chemical_list: D051844:alpha-Synuclein