title: Somatic markers mediate the effect of serotonin transporter gene polymorphisms on Iowa Gambling Task.
abstract: This study investigated whether somatic markers mediate the effect of serotonin transporter genotype on Iowa Gambling Task (IGT) performance. Participants (N = 135) were genotyped for the insertion/deletion and single-nucleotide (rs25531) polymorphisms in the promoter region of the serotonin transporter gene (5-HTTLPR). The results of mediation analyses indicated that skin conductance responses that anticipated IGT card selections partially (i.e. 42% of the total effect) mediated the effect of genotype on IGT performance. In comparison with high-functioning 5-HTTLPR genotypes, the low-functioning genotypes were associated with higher total IGT scores. This suggests that the higher synaptic availability of serotonin, associated with the low-functioning 5-HTTLPR genotypes, may confer differential susceptibility to decision making under risk, and that almost half of this effect is explained by facilitated somatic markers during IGT.
authors.affiliation: Cognitive Neuroscience Laboratory, Department of Psychology, Babeş-Bolyai University, Cluj-Napoca, Romania. andreimiu@psychology.ro
authors.forename: A C
authors.initials: AC
authors.lastname: Miu
authors.forename: L G
authors.initials: LG
authors.lastname: Crişan
authors.forename: A
authors.initials: A
authors.lastname: Chiş
authors.forename: L
authors.initials: L
authors.lastname: Ungureanu
authors.forename: B
authors.initials: B
authors.lastname: Drugă
authors.forename: R
authors.initials: R
authors.lastname: Vulturar
mesh_terms: D000293:Adolescent; D000328:Adult; D003657:Decision Making / Q000502:physiology*; D005260:Female; D005715:Gambling; D005838:Genotype; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*
chemical_list: D050486:Serotonin Plasma Membrane Transport Proteins