title: [Diffusion-Weighted Imaging infarct volume and neurologic outcomes after ischemic stroke].
abstract: BACKGROUND
  This study's purpose was to demonstrate a relationship between growth of stroke volume measured on Diffusion-Weighted MRI (DWI) at admission (baseline) and 24 hours later (follow-up) and functional outcome at 90 days evaluated by the modified Rankin Scale (mRS).
  
  
  METHODS
  DWI infarct volumes were calculated, using an Analyze Software. Clinical outcomes were assessed at 90 days by the mRS. Univariate regression analysis was performed to assess the relationship between changes in DWI lesion volume and mRS less or equal to 1.
  
  
  RESULTS
  Sixty-nine cases had serial DWI scans with a measurable lesion at baseline and follow-up. The median baseline National Institutes of Health Stroke Scale (NIHSS) was 10, 5 and 7 at 24 hours. At 90 days, the proportion of patients with Rankin less or equal to 1 was 51.7%. The average baseline volume was 19.7 cm(3) and average follow-up volume was 46.1 cm(3). For each 10 cm(3) of growth in DWI infarct volume, the odds ratio for a mRS less or equal to 1 was 10,1 (IC 95%, 3-33.9).
  
  
  CONCLUSIONS
  The results of this study provide evidence of a significant inverse relationship between infarct growth measured by DWI and good functional clinical outcome at 90 days.
authors.affiliation: CHU de Limoges, Neuroradiology-Radiology Department, 87000 Limoges, France. aattye@chu-grenoble.fr
authors.forename: A
authors.initials: A
authors.lastname: Attyé
authors.forename: M-P
authors.initials: MP
authors.lastname: Boncoeur-Martel
authors.forename: A
authors.initials: A
authors.lastname: Maubon
authors.forename: C
authors.initials: C
authors.lastname: Mounayer
authors.forename: P
authors.initials: P
authors.lastname: Couratier
authors.forename: A
authors.initials: A
authors.lastname: Labrunie
authors.forename: J-F
authors.initials: JF
authors.lastname: Le Bas
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy; D016009:Chi-Square Distribution; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D020127:Recovery of Function; D012044:Regression Analysis; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D012984:Software; D020521:Stroke / Q000473:pathology* / Q000503:physiopathology / Q000628:therapy; D015912:Thrombolytic Therapy; D016896:Treatment Outcome