title: Passive immune neutralization strategies for prevention and control of influenza A infections.
abstract: Although vaccination significantly reduces influenza severity, seasonal human influenza epidemics still cause more than 250,000 deaths annually. Vaccine efficacy is limited in high-risk populations such as infants, the elderly and immunosuppressed individuals. In the event of an influenza pandemic (such as the 2009 H1N1 pandemic), a significant delay in vaccine availability represents a significant public health concern, particularly in high-risk groups. The increasing emergence of strains resistant to the two major anti-influenza drugs, adamantanes and neuraminidase inhibitors, and the continuous circulation of avian influenza viruses with pandemic potential in poultry, strongly calls for alternative prophylactic and treatment options. In this review, we focus on passive virus neutralization strategies for the prevention and control of influenza type A viruses.
authors.affiliation: Department of Veterinary Medicine, University of Maryland, College Park & Virginia - Maryland Regional College of Veterinary Medicine, College Park, MD 20742, USA.
authors.forename: Jianqiang
authors.initials: J
authors.lastname: Ye
authors.forename: Hongxia
authors.initials: H
authors.lastname: Shao
authors.forename: Daniel R
authors.initials: DR
authors.lastname: Perez
mesh_terms: D000818:Animals; D006801:Humans; D007116:Immunization, Passive; D009980:Influenza A virus / Q000276:immunology* / Q000472:pathogenicity; D007252:Influenza Vaccines / Q000008:administration & dosage*; D005585:Influenza in Birds / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control*; D007251:Influenza, Human / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control*; D058873:Pandemics / Q000517:prevention & control*; D011200:Poultry; D012621:Seasons
chemical_list: D007252:Influenza Vaccines