title: Stem cells in brain tumour development and therapy- two-sides of the same coin.
abstract: Primary brain tumours are difficult to manage clinically due to their abilities to invade adjacent tissue and infiltrate distant neuropil. These contribute to challenges in surgical management and also limit the effectiveness of radiotherapy. Despite initial responses to chemotherapy, most tumours become chemo-resistant, leading to relapse. Recent identification and isolation of brain cancer stem cells (BCSCs) have broadened our understanding of the molecular pathogenesis and potential Achilles' heel of brain tumours. BCSCs are thought to drive and propagate the tumour and therefore present an important target for further investigations. This review explores the history of the discovery of BCSCs and the evolving concept of "cancer stem cells" in neuro-oncology. We attempt to present a balanced view on the subject and also to update the readers on the molecular biology of BCSCs. Lastly, we outline the potential strategies to target BCSCs which will translate into specific and effective therapies for brain tumours.
authors.affiliation: Department of Pediatrics, Experimental Medicine and Medical Genetics, Child and Family Research Institute, University of British Columbia, BC, Canada.
authors.forename: Cathy
authors.initials: C
authors.lastname: Lee
authors.forename: Sandra E
authors.initials: SE
authors.lastname: Dunn
authors.forename: Stephen
authors.initials: S
authors.lastname: Yip
mesh_terms: D001932:Brain Neoplasms / Q000473:pathology / Q000601:surgery*; D006801:Humans; D014411:Neoplastic Stem Cells / Q000473:pathology*; D033581:Stem Cell Transplantation