title: Catalytic metallodrugs targeting HCV IRES RNA.
abstract: A catalytic metallodrug that targets stem-loop IIb of the internal ribosomal entry site (IRES) RNA of hepatitis C virus (HCV) demonstrates enzyme-like turnover with K(M) of 0.85 μM, k(cat) of 0.53 min(-1), and a turnover number of 31.9 for Cu·GGHYrFK-amide (1-Cu), and yielded an antiviral activity (IC(50)) of 0.58 μM in an HCV cellular replicon assay.
authors.affiliation: Department of Chemistry, The Ohio State University, 100 W, 18th Ave, Columbus, OH 43210, USA.
authors.forename: Seth
authors.initials: S
authors.lastname: Bradford
authors.forename: J A
authors.initials: JA
authors.lastname: Cowan
mesh_terms: D000595:Amino Acid Sequence; D000998:Antiviral Agents / Q000737:chemistry* / Q000378:metabolism; D001665:Binding Sites; D002384:Catalysis; D016174:Hepacivirus / Q000235:genetics*; D007700:Kinetics; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D012335:RNA, Ribosomal / Q000378:metabolism*; D012367:RNA, Viral / Q000187:drug effects / Q000378:metabolism*; D012093:Replicon / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D004364:Pharmaceutical Preparations; D012335:RNA, Ribosomal; D012367:RNA, Viral