title: [P53 expression in liver tissue of patients with chronic hepatitis B and its influencing factors].
abstract: OBJECTIVE
  To observe p53 expression in liver tissue of patients with chronic hepatitis B and its influencing factors.
  
  
  METHODS
  17 cases HBeAg-negative chronic hepatitis B patients and 31 cases HBeAg-positive chronic hepatitis B patients were divided into 2 groups.
  
  
  RESULTS
  (1) HBeAg-negative chronic hepatitis B patients were older, mostly male and HBV DNA lower. These three indicators between two groups patients appeared statistical difference. Serum markers were no statistical difference between two groups patients except Glo. (2) Pathological inflammation and fibrosis Staging were no statistical difference between two groups patients. p53 expression positive rate and p53 expression semi-quantitative scoring in liver tissue were no statistical difference between the two groups. (3) Logistic regression analysis showed that only liver fibrosis staging (S) is a risk factor for p53 expression. Compared with the S0-1, p53 expression increased by 3.9 times the rate of positive in S > or = 2.
  
  
  CONCLUSIONS
  Liver fibrosis staging in patients with chronic hepatitis B is a risk factor for p53 positive expression in liver.
authors.affiliation: The Sixth People' Hospital of Hangzhou, Zhejiang 310014, China. guojianchun1961@126.com
authors.forename: Jian-Chun
authors.initials: JC
authors.lastname: Guo
authors.forename: Xiang-Hua
authors.initials: XH
authors.lastname: Ma
authors.forename: Yun-Hao
authors.initials: YH
authors.lastname: Xun
authors.forename: Li-Na
authors.initials: LN
authors.lastname: Xiao
authors.forename: Wei-Zhen
authors.initials: WZ
authors.lastname: Shi
authors.forename: Jun-Ping
authors.initials: JP
authors.lastname: Shi
authors.forename: Wei-Wei
authors.initials: WW
authors.lastname: Wang
authors.forename: Guo-Qiang
authors.initials: GQ
authors.lastname: Lou
mesh_terms: D000328:Adult; D006513:Hepatitis B e Antigens / Q000097:blood; D019694:Hepatitis B, Chronic / Q000097:blood / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D006801:Humans; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016159:Tumor Suppressor Protein p53 / Q000235:genetics* / Q000378:metabolism
chemical_list: D006513:Hepatitis B e Antigens; D016159:Tumor Suppressor Protein p53