title: [Association between CTLA-4 gene polymorphism and susceptibility to cervical cancer].
abstract: OBJECTIVE
  To investigate the association between CTLA-4 +49A/G polymorphisms and the risk of susceptibility to cervical cancer.
  
  
  METHODS
  A hospital-based case-control study was conducted. 314 cases with primary cervical cancer and 320 healthy controls were collected and genotyped by PCR-based RFLP for +49A/G polymorphisms in the CTLA-4 gene.
  
  
  RESULTS
  The A allele and AA genotype of CTLA-4 gene were 32.5% and 9.6% in the patients, and 25.8% and 5.6% in the controls, respectively. Subjects with CTLA-4 +49AA genotype conferred a higher risk of cervical cancer (OR = 2.06, 95%CI: 1.10 - 3.85; P = 0.024). However, the correlation between AA genotype in CTLA-4 polymorphisms and clinicopathological characteristics was not significant.
  
  
  CONCLUSIONS
  The results of this study suggest that CTLA4 gene is associated with cervical cancer risk and may be a susceptible gene of cervical cancer.
authors.affiliation: Department of Obstetrics and Gynecology, Third Hospital, Peking University, Beijing, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Li
authors.forename: Yi-feng
authors.initials: YF
authors.lastname: Zhou
authors.forename: Hong-yan
authors.initials: HY
authors.lastname: Guo
authors.forename: Tong
authors.initials: T
authors.lastname: Sun
authors.forename: Wen-hua
authors.initials: WH
authors.lastname: Zhang
authors.forename: Dong-xin
authors.initials: DX
authors.lastname: Lin
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D000328:Adult; D000368:Aged; D000483:Alleles; D060908:CTLA-4 Antigen / Q000235:genetics* / Q000378:metabolism; D002278:Carcinoma in Situ / Q000235:genetics* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology / Q000601:surgery
chemical_list: D060908:CTLA-4 Antigen