title: Spectrum of Guillain-Barré syndrome in tertiary care hospital at Kolkata.
abstract: OBJECTIVE
  In childhood Guillain-Barré syndrome (GBS), the clinical profiles using intravenous immunoglobulin (IVIg) in addition to supportive care were studied.
  
  
  METHODS
  This was a retrospective analysis of 139 children with severe GBS admitted to our respiratory care unit managed with the IVIg as an adjunct intervention to conventional supportive and respiratory care.
  
  
  RESULTS
  In our case series of 139 cases, motor weakness was the most common presenting feature. Antecedent illness was found in 66.7% of cases in the preceding two weeks, which included nonspecific illness, acute respiratory infection, diarrhea, and chickenpox. At onset, sensory symptoms (pain and paresthesia) were noted in 59% of the cases and limb weakness in 77%. On admission, a majority (61.54%) were in Hughes neurological disability grading stage V; all had limb weakness at the peak deficit, autonomic disturbance was seen in 35.8%, and bulbar palsy in 52%. Duration of illness was less than three weeks in 67% of cases. The mean duration of ventilation was 21.5 days (range, 5-60 days).
  
  
  CONCLUSIONS
  Male preponderance and motor weakness was the most common presenting illness and a majority achieved full recovery in our series. Although IVIg may be useful in the treatment of GBS, the key issue is excellent intensive care unit management.
authors.affiliation: Department of Anesthesiology, Institute of Postgraduate Medical Education and Research, Kolkata, India.
authors.forename: Ujjal Kr
authors.initials: UK
authors.lastname: Sarkar
authors.forename: Lalita
authors.initials: L
authors.lastname: Menon
authors.forename: Debabrata
authors.initials: D
authors.lastname: Sarbapalli
authors.forename: Ranabir
authors.initials: R
authors.lastname: Pal
authors.forename: Forhad Akhtar
authors.initials: FA
authors.lastname: Zaman
authors.forename: Sumit
authors.initials: S
authors.lastname: Kar
authors.forename: Jyoti
authors.initials: J
authors.lastname: Singh
authors.forename: Mohan
authors.initials: M
authors.lastname: Mondal
authors.forename: Soma
authors.initials: S
authors.lastname: Mukherjee