title: Fluorodeoxyglucose positron emission tomography in Richardson’s syndrome and progressive supranuclear palsy-parkinsonism.
abstract: BACKGROUND
  We hypothesized that postural instability and cognitive decline in patients with Richardson’s syndrome could be a consequence of reduced thalamic and frontal metabolism. Severe Parkinsonian signs in patients with progressive supranuclear palsy-parkinsonism may be reflected by alterations in putaminal metabolism.
  
  
  METHODS
  Eleven patients with Richardson’s syndrome, 8 patients with progressive supranuclear palsy-parkinsonism, 12 with Parkinson’s disease, and 10 controls underwent clinical assessment and fluorodeoxyglucose positron emission tomography (PET).
  
  
  RESULTS
  Richardson’s syndrome patients showed pronounced thalamic hypometabolism, and patients with progressive supranuclear palsy-parkinsonism pronounced putaminal hypometabolism, compared to all other investigated groups. The putamen/thalamus uptake ratio differentiated progressive supranuclear palsy-parkinsonism from Richardson’s syndrome (area under the curve 5 0.86) and from Parkinson’s disease (area under the curve 5 0.80) with acceptable accuracy. Frontal hypometabolism was predominantly found in Richardson’s syndrome patients.
  
  
  CONCLUSIONS
  Richardson’s syndrome, progressive supranuclear palsy-parkinsonism and Parkinson’s disease showed different metabolic patterns in fluorodeoxyglucose PET.
authors.affiliation: Department of Neurodegeneration, Hertie Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany.
authors.forename: Karin
authors.initials: K
authors.lastname: Srulijes
authors.forename: Matthias
authors.initials: M
authors.lastname: Reimold
authors.forename: Rajka M
authors.initials: RM
authors.lastname: Liscic
authors.forename: Sarah
authors.initials: S
authors.lastname: Bauer
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Dietzel
authors.forename: Inga
authors.initials: I
authors.lastname: Liepelt-Scarfone
authors.forename: Daniela
authors.initials: D
authors.lastname: Berg
authors.forename: Walter
authors.initials: W
authors.lastname: Maetzler
mesh_terms: D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology; D049268:Positron-Emission Tomography; D011699:Putamen / Q000000981:diagnostic imaging; D012372:ROC Curve; D012720:Severity of Illness Index; D013494:Supranuclear Palsy, Progressive / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology; D013788:Thalamus / Q000000981:diagnostic imaging
chemical_list: D019788:Fluorodeoxyglucose F18