title: Catalytic asymmetric synthesis of optically active allenes from terminal alkynes.
abstract: CuBr and ZnI(2) have been developed as catalysts or subcatalysts for the efficient asymmetric synthesis of axially chiral allenols with up to 97% ee from readily available propargylic alcohols, aliphatic or aromatic aldehyde, pyrrolidine, and commerically available ligands. The alcohol unit in the terminal alkynes plays a very important role for ensuring high enantioselectivity via coordination.
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, PR China.
authors.forename: Juntao
authors.initials: J
authors.lastname: Ye
authors.forename: Suhua
authors.initials: S
authors.lastname: Li
authors.forename: Bo
authors.initials: B
authors.lastname: Chen
authors.forename: Wu
authors.initials: W
authors.lastname: Fan
authors.forename: Jinqiang
authors.initials: J
authors.lastname: Kuang
authors.forename: Jinxian
authors.initials: J
authors.lastname: Liu
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
authors.forename: Bukeyan
authors.initials: B
authors.lastname: Miao
authors.forename: Baoqiang
authors.initials: B
authors.lastname: Wan
authors.forename: Yuli
authors.initials: Y
authors.lastname: Wang
authors.forename: Xi
authors.initials: X
authors.lastname: Xie
authors.forename: Qiong
authors.initials: Q
authors.lastname: Yu
authors.forename: Weiming
authors.initials: W
authors.lastname: Yuan
authors.forename: Shengming
authors.initials: S
authors.lastname: Ma