title: Severe acute respiratory failure secondary to acute fibrinous and organizing pneumonia requiring mechanical ventilation: a case report and literature review.
abstract: A 27-year-old woman was admitted to our ICU with acute hypoxemic respiratory failure and criteria for ARDS. Despite an F(IO(2)) of 1.0 and a lung protective strategy, the patient died on day 15 without any improvement. The relatives gave consent for post-mortem analysis.  The histopathologic study of the lung showed findings typical of an acute fibrinous and organizing pneumonia. Apropos of this case we performed a PubMed search. We found 13 articles, including a total of 29 patients. Acute fibrinous and organizing pneumonia is an unusual cause of acute lung  injury. The diagnostic criterion is histopathologic. There is little information regarding the pathophysiology of this illness. Important questions remain regarding this disease, including predisposing factors and management. Patients who require mechanical ventilation have poor outcomes.
authors.affiliation: Intensive Care Unit, Hospital Universitario de Getafe, Madrid, Spain. sonia_l_c@hotmail.com
authors.forename: Sonia
authors.initials: S
authors.lastname: López-Cuenca
authors.forename: Silvia
authors.initials: S
authors.lastname: Morales-García
authors.forename: Ana
authors.initials: A
authors.lastname: Martín-Hita
authors.forename: Fernando
authors.initials: F
authors.lastname: Frutos-Vivar
authors.forename: Pilar
authors.initials: P
authors.lastname: Fernández-Segoviano
authors.forename: Andrés
authors.initials: A
authors.lastname: Esteban
mesh_terms: D000015:Abnormalities, Multiple / Q000503:physiopathology; D000328:Adult; D054119:Arachnodactyly / Q000503:physiopathology; D016569:Blepharophimosis / Q000503:physiopathology; D003240:Connective Tissue Diseases / Q000503:physiopathology; D003286:Contracture / Q000503:physiopathology; D018549:Cryptogenic Organizing Pneumonia / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D011658:Pulmonary Fibrosis / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D012121:Respiration, Artificial / Q000379:methods*; D012128:Respiratory Distress Syndrome / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*