title: Effective protection induced by three different versions of the porcine S3Pvac anticysticercosis vaccine against rabbit experimental Taenia pisiformis cysticercosis.
abstract: In an effort to develop an effective and affordable oral vaccine against porcine Taenia solium cysticercosis, the S3Pvac anti-cysticercosis vaccine was expressed in papaya calli. Taenia pisiformis experimental rabbit cysticercosis was used as a model to compare the efficacy of the oral vaccine vs. the injectable S3Pvac-synthetic and S3Pvac-phage versions. Oral S3Pvac-papaya significantly reduced the expected number of hepatic lesions and peritoneal cysticerci to a similar extent than the injectable vaccines. This study reports for the first time an effective oral vaccine against T. pisiformis cysticercosis, possibly useful against porcine T. solium cysticercosis.
authors.affiliation: Facultad de Medicina Veterinaria y Zootecnia, Universidad Nacional Autónoma de México. Av. Universidad 3000, Mexico.
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Betancourt
authors.forename: Aline S
authors.initials: AS
authors.lastname: de Aluja
authors.forename: Edda
authors.initials: E
authors.lastname: Sciutto
authors.forename: Marisela
authors.initials: M
authors.lastname: Hernández
authors.forename: Raúl J
authors.initials: RJ
authors.lastname: Bobes
authors.forename: Gabriela
authors.initials: G
authors.lastname: Rosas
authors.forename: Beatriz
authors.initials: B
authors.lastname: Hernández
authors.forename: Gladis
authors.initials: G
authors.lastname: Fragoso
authors.forename: Claudia
authors.initials: C
authors.lastname: Hallal-Calleros
authors.forename: Liliana
authors.initials: L
authors.lastname: Aguilar
authors.forename: Iván
authors.initials: I
authors.lastname: Flores-Peréz
mesh_terms: D000818:Animals; D001483:Base Sequence; D003551:Cysticercosis / Q000473:pathology / Q000517:prevention & control*; D003552:Cysticercus / Q000276:immunology; D005260:Female; D007249:Inflammation / Q000276:immunology / Q000473:pathology; D019476:Insect Proteins / Q000235:genetics; D008099:Liver / Q000276:immunology / Q000473:pathology; D008969:Molecular Sequence Data; D009245:NADH Dehydrogenase / Q000235:genetics; D010529:Peritoneal Cavity / Q000469:parasitology / Q000473:pathology; D016052:Protozoan Vaccines / Q000008:administration & dosage / Q000276:immunology; D011817:Rabbits; D016415:Sequence Alignment; D013621:Taenia / Q000235:genetics / Q000276:immunology*
chemical_list: D019476:Insect Proteins; D016052:Protozoan Vaccines; D009245:NADH Dehydrogenase