title: Relation between mean platelet volume and severity of atherosclerosis in patients with acute coronary syndromes.
abstract: Platelets play a central role in the pathophysiology of coronary artery disease (CAD). Increased mean platelet volume (MPV) is an indicator of platelet function and associated with poor clinical outcome in patients with acute coronary syndrome (ACS). We evaluated the relationship between MPV and severity of CAD in patients with ACS. A total of 395 patients with ACS were included. Severity of CAD was assessed with the Gensini and Syntax scores. High levels of MPV were associated with the Gensini and Syntax scores, number of diseased vessels (>50%), number of critical lesions (>50% and >70%), and noncritical lesions. After multivariate analysis, high levels of MPV were independent predictors of multivessel CAD together with age. In patients with ACS, high MPV levels were associated with severity of CAD. It is possible that MPV can be a helpful marker in patients with CAD for the severity of coronary atherosclerosis.
authors.affiliation: Etlik Ihtisas Research and Education Hospital, Ankara, Turkey.
authors.forename: Sani Namik
authors.initials: SN
authors.lastname: Murat
authors.forename: Mustafa
authors.initials: M
authors.lastname: Duran
authors.forename: Nihat
authors.initials: N
authors.lastname: Kalay
authors.forename: Ozgur
authors.initials: O
authors.lastname: Gunebakmaz
authors.forename: Mahmut
authors.initials: M
authors.lastname: Akpek
authors.forename: Cihan
authors.initials: C
authors.lastname: Doger
authors.forename: Deniz
authors.initials: D
authors.lastname: Elcik
authors.forename: Ayse
authors.initials: A
authors.lastname: Ocak
authors.forename: Mehmet Akif
authors.initials: MA
authors.lastname: Vatankulu
authors.forename: Murat
authors.initials: M
authors.lastname: Turfan
authors.forename: Haci Ahmet
authors.initials: HA
authors.lastname: Kasapkara
authors.forename: Fatih
authors.initials: F
authors.lastname: Akin
authors.forename: Musa
authors.initials: M
authors.lastname: Sahin
authors.forename: Mehmet Gungor
authors.initials: MG
authors.lastname: Kaya
mesh_terms: D054058:Acute Coronary Syndrome / Q000097:blood* / Q000150:complications*; D050197:Atherosclerosis / Q000097:blood* / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D011446:Prospective Studies; D012720:Severity of Illness Index