title: Silica based click amino stationary phase for ion chromatography and hydrophilic interaction liquid chromatography.
abstract: A silica based amino stationary phase was prepared by immobilization of propargylamine on azide-silica via click chemistry. This readily prepared click amino stationary phase demonstrated good selectivity in separation of common inorganic anions under ion chromatography (IC) mode, and the triazole ring in combination with free amino group was observed to play a major role for separation of the anions examined. On the other hand, the stationary phase also showed good hydrophilic interaction liquid chromatography (HILIC) properties in the separation of polar compounds including nucleosides, organic acids and bases. The retention mechanism was found to match well the typical HILIC retention.
authors.affiliation: School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
authors.forename: Yajing
authors.initials: Y
authors.lastname: Liu
authors.forename: Qing
authors.initials: Q
authors.lastname: Du
authors.forename: Bingcheng
authors.initials: B
authors.lastname: Yang
authors.forename: Feifang
authors.initials: F
authors.lastname: Zhang
authors.forename: Changhu
authors.initials: C
authors.lastname: Chu
authors.forename: Xinmiao
authors.initials: X
authors.lastname: Liang
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D002852:Chromatography, Ion Exchange / Q000379:methods*; D057930:Click Chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D015394:Molecular Structure; D012822:Silicon Dioxide / Q000737:chemistry*; D014230:Triazoles / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D014230:Triazoles; D012822:Silicon Dioxide