title: A simple computational cell: coupling boolean gene and protein networks.
abstract: This article presents an abstract, tunable model containing two of the principal information-processing features of cells and explores its use with simulated evolution. The random Boolean model of genetic regulatory networks is extended to include a protein interaction network. The underlying behavior of the resulting two coupled dynamical networks is investigated before their evolvability is explored using a version of the NK model of fitness landscapes.
authors.affiliation: Department of Computer Science & Creative Technologies, University of the West of England, UK. Larry.Bull@uwe.ac.uk
authors.forename: Larry
authors.initials: L
authors.lastname: Bull
mesh_terms: D005075:Biological Evolution; D053263:Gene Regulatory Networks; D015233:Models, Statistical; D011506:Proteins / Q000378:metabolism*
chemical_list: D011506:Proteins