title: Synthesis of a liphagal-frondosin C hybrid and speculation on the biosynthesis of the frondosins.
abstract: A hypothesis for the biosynthesis of the frondosins A-E is presented. Synthesis of a liphagal-frondosin C hybrid molecule has been achieved, with the frondosin C 6-7-5-6 ring system being constructed by a photochemical process that follows an intramolecular Paternò-Büchi reaction/fragmentation pathway.
authors.affiliation: School of Chemistry & Physics, University of Adelaide, North Terrace, Adelaide SA 5005, Australia.
authors.forename: Henry P
authors.initials: HP
authors.lastname: Pepper
authors.forename: Kevin K W
authors.initials: KK
authors.lastname: Kuan
authors.forename: Jonathan H
authors.initials: JH
authors.lastname: George
mesh_terms: D000818:Animals; D002384:Catalysis; D003500:Cyclization; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000737:chemistry; D008386:Marine Biology; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry
chemical_list: D006576:Heterocyclic Compounds, 4 or More Rings; C506349:frondosin C