title: Audit on the usage of plasma derived/recombinant coagulation factor concentrates at a German university hospital.
abstract: BACKGROUND
  There is a lack of data on the usage of plasma derived/recombinant coagulation factor concentrates (PD/RCFC) regarding diagnostic categories. An audit of PD/RCFC and blood component usage at a tertiary care teaching hospital in northern Bavaria was conducted.
  
  
  METHODS
  All blood components and PD/RCFC transfused at a university hospital (Erlangen, Germany) during the year 2006 were analysed. Transfused blood products were listed by major diagnostic categories (MDC) formed from principal diagnoses of recipients according to the International Classification of Diseases, tenth revision and German modification.
  
  
  RESULTS
  Blood component usage has markedly increased since last surveyed in 1994 through 1996. The diagnostic categories responsible for most transfusions have not changed since. Antithrombin is the PD/RCFC used most, whereas most money for PD/RCFC was spent on FVIII concentrates. Polytrauma patients need most fibrinogen, whereas most of FXIII is needed in patients with malignancies. Patients with prolonged artificial ventilation receive PCC most often. Altogether, three MDCs (Pre, 17, 05) accounted for 80·5% of costs created by PD/RCFC transfusion.
  
  
  CONCLUSIONS
  This study provides for the first time combined data on blood component and PD/RCFC usage in a German university hospital. It shows that the MDCs responsible for most of the costs in transfusion therapy with blood components and with PD/RCFC are few, and are the same. At the same time, blood bank information software should be further improved in order to be able to identify new trends in hemotherapy in more detail.
authors.affiliation: Department of Transfusion Medicine and Hemostaseology, Friedrich-Alexander-University Erlangen-Nuremberg, Germany. julian.strobel@uk-erlangen.de
authors.forename: J
authors.initials: J
authors.lastname: Strobel
authors.forename: H
authors.initials: H
authors.lastname: Jörns
authors.forename: V
authors.initials: V
authors.lastname: Weisbach
authors.forename: T
authors.initials: T
authors.lastname: Ganslandt
authors.forename: R
authors.initials: R
authors.lastname: Zimmermann
authors.forename: R
authors.initials: R
authors.lastname: Eckstein
mesh_terms: D001779:Blood Coagulation Factors; D005858:Germany; D006784:Hospitals, Teaching; D006801:Humans; D008485:Medical Audit; D011994:Recombinant Proteins
chemical_list: D001779:Blood Coagulation Factors; D011994:Recombinant Proteins