title: Maintaining muscle mitochondria via transsynaptic signaling.
abstract: Dominant VAPB mutations are implicated in neurodegenerative disease, including amyotrophic lateral sclerosis and spinal muscular atrophy. In the current issue, Han et al. (2012) uncover a mechanism through which the secreted VAPB MSP domain regulates actin organization and mitochondrial function in muscle cells through LAR and Robo receptor activation.
authors.affiliation: Department of Cell Biology and Program in Neuroscience, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Jennifer B
authors.initials: JB
authors.lastname: Long
authors.forename: David
authors.initials: D
authors.lastname: Van Vactor