title: Triggered optical coherence tomography for capturing rapid periodic motion.
abstract: Quantitative cross-sectional imaging of vocal folds during phonation is potentially useful for diagnosis and treatments of laryngeal disorders. Optical coherence tomography (OCT) is a powerful technique, but its relatively low frame rates makes it challenging to visualize rapidly vibrating tissues. Here, we demonstrate a novel method based on triggered laser scanning to capture 4-dimensional (4D) images of samples in motu at audio frequencies over 100 Hz. As proof-of-concept experiments, we applied this technique to imaging the oscillations of biopolymer gels on acoustic vibrators and aerodynamically driven vibrations of the vocal fold in an ex vivo calf larynx model. Our results suggest that triggered 4D OCT may be useful in understanding and assessing the function of vocal folds and developing novel treatments in research and clinical settings.
authors.affiliation: Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, USA; Department of Biomedical Engineering, Boston University, Boston, MA, USA.
authors.forename: Ernest W
authors.initials: EW
authors.lastname: Chang
authors.forename: James B
authors.initials: JB
authors.lastname: Kobler
authors.forename: Seok H
authors.initials: SH
authors.lastname: Yun
mesh_terms: D000818:Animals; D001683:Biological Clocks / Q000502:physiology*; D002417:Cattle; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D009991:Oscillometry / Q000379:methods*; D041623:Tomography, Optical Coherence / Q000379:methods*; D014732:Vibration; D014827:Vocal Cords / Q000033:anatomy & histology* / Q000502:physiology*