title: Cytotoxic chalcones and antioxidants from the fruits of a Syzygium samarangense (Wax Jambu).
abstract: Bioassay-guided fractionation of the methanolic extracts of the pulp and seeds of the fruits of Syzygium samarangense Merr. & Perry (Blume) led to the identification of four cytotoxic compounds and eight antioxidants on the basis of HPLC-PDA analysis, MS, and various NMR spectroscopic techniques. Three C-methylated chalcones, 2',4'-dihydroxy-3',5'-dimethyl-6'-methoxychalcone (1), 2',4'-dihydroxy-3'-methyl-6'-methoxychalcone (stercurensin, 2), and 2',4'-dihydroxy-6'-methoxychalcone (cardamonin, 3), were isolated and displayed cytotoxic activity (IC(50) = 10, 35, and 35 μM, respectively) against the SW-480 human colon cancer cell line. Also a number of known antioxidants were obtained including six quercetin glycosides: reynoutrin (4), hyperin (5), myricitrin (6), quercitrin (7), quercetin (9), and guaijaverin (10), one flavanone: (S)-pinocembrin (8), and two phenolic acids: gallic acid (11) and ellagic acid (12).
authors.affiliation: Department of Biological Sciences, Lehman College, and The Graduate Center, City University of New York, 250 Bedford Park Boulevard West, Bronx, NY, 10468.
authors.forename: Mario J
authors.initials: MJ
authors.lastname: Simirgiotis
authors.forename: Seiji
authors.initials: S
authors.lastname: Adachi
authors.forename: Satoshi
authors.initials: S
authors.lastname: To
authors.forename: Hui
authors.initials: H
authors.lastname: Yang
authors.forename: Kurt A
authors.initials: KA
authors.lastname: Reynertson
authors.forename: Margaret J
authors.initials: MJ
authors.lastname: Basile
authors.forename: Roberto R
authors.initials: RR
authors.lastname: Gil
authors.forename: I Bernard
authors.initials: IB
authors.lastname: Weinstein
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Kennelly