title: Major hemobilia--experience from a specialist unit in a developing country.
abstract: OBJECTIVE
  Hemobilia is a rare but potentially life threatening problem, which can be difficult to diagnose and treat. In the last few decades there has been a change in the etiologic spectrum and management of this problem in the West. The aim of this study was to analyze the etiology, clinical features, management and outcome of major hemobilia in a tertiary referral centre from western India.
  
  
  METHODS
  A retrospective analysis was undertaken on 22 patients (16 males, 6 females; mean age 39 years, range 13 to 74) who presented with major hemobilia over a 5-year period.
  
  
  RESULTS
  The etiology was iatrogenic in 13 patients (percutaneous transhepatic biliary drainage 8, post laparoscopic cholecystectomy 3, endoscopic retrograde cholangiopancreatography 1, and liver biopsy 1), liver trauma in 6 and liver tumors in 3 patients. Twenty patients presented with gastrointestinal bleeding (melena 20 patients, hemetemesis with melena 8 patients), 5 with jaundice and 8 had fever. Abdominal angiography was performed in 20 patients. Angiography revealed pseudoaneurysm of the right hepatic artery or its branches in 14 patients, left hepatic artery in 2, an arterio-biliary fistula in 1, tumor blush in 1 and the source could not be located in 2 patients. Seventeen of the 22 patients were treated with radiological intervention, 3 required surgery (liver resection for tumors 2, laparotomy for venous collateral bleeding of portal cavernoma 1) and two were managed conservatively. Radiological intervention involved embolisation with coils and/or glue in 16, and chemoembolisation in 1 patient. Sixteen of 17 patients responded to embolisation. Overall there were two deaths.
  
  
  CONCLUSIONS
  The spectrum of hemobilia seen in India is now similar to that in the developed world with iatrogenic causes being the commonest. Interventional radiology can treat a majority of patients reducing the need and morbidity associated with surgery.
authors.affiliation: Department of Gastrointestinal Surgery, Jaslok Hospital and Research Centre, Mumbai - 400026, India.
authors.forename: Vidhyachandra
authors.initials: V
authors.lastname: Gandhi
authors.forename: Nilesh
authors.initials: N
authors.lastname: Doctor
authors.forename: Shaji
authors.initials: S
authors.lastname: Marar
authors.forename: Aabha
authors.initials: A
authors.lastname: Nagral
authors.forename: Sanjay
authors.initials: S
authors.lastname: Nagral
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000792:Angiography; D002758:Cholangiography; D004621:Embolization, Therapeutic; D016099:Endoscopy, Gastrointestinal; D005260:Female; D006431:Hemobilia / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy*; D006801:Humans; D007049:Iatrogenic Disease; D007194:India / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015641:Radiography, Interventional; D012189:Retrospective Studies