title: Treatment of repeated and multiple new-onset osteoporotic vertebral compression fractures with teriparatide.
abstract: Percutaneous vertebroplasty (PVP) has played an increasing role in the treatment of osteoporotic compression fracture. The number of prior vertebral fractures and prior vertebroplasties are important risk factors for future fractures. We prospectively evaluated the effectiveness of teriparatide therapy for 28 patients who had repeated and multiple new-onset vertebral compression fractures (VCF). None of the patients required PVP or experienced a new-onset vertebral fracture during the treatment and follow-up period of at least 18 months. Teriparatide therapy significantly decreased visual analogue scale pain scores, increased Japanese Orthopaedic Association function scores, increased spinal bone mineral density, and prevented new-onset VCF. Teriparatide can be used in patients who have repeated and multiple new-onset painful VCF to avoid repeated vertebroplasty. Therapy should continue for at least six months to ensure it is effective.
authors.affiliation: Department of Neurosurgery, Chang Gung Memorial Hospital, Chang Gung Medical College and University, 5 Fu-Shin Street, Kwei-Shan Hsiang, Taoyuan Hsien 333, Taiwan.
authors.forename: Po-Hsun
authors.initials: PH
authors.lastname: Tu
authors.forename: Zhuo-Hao
authors.initials: ZH
authors.lastname: Liu
authors.forename: Shih-Tseng
authors.initials: ST
authors.lastname: Lee
authors.forename: Jyi-Feng
authors.initials: JF
authors.lastname: Chen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density / Q000187:drug effects; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D005260:Female; D050815:Fractures, Compression / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000150:complications / Q000188:drug therapy*; D010147:Pain Measurement; D016103:Spinal Fractures / Q000188:drug therapy* / Q000209:etiology; D019379:Teriparatide / Q000627:therapeutic use*
chemical_list: D050071:Bone Density Conservation Agents; D019379:Teriparatide