title: Targeting glucose metabolism for cancer therapy.
abstract: Cellular transformation is associated with the reprogramming of cellular pathways that control proliferation, survival, and metabolism. Among the metabolic changes exhibited by tumor cells is an increase in glucose metabolism and glucose dependence. It has been hypothesized that targeting glucose metabolism may provide a selective mechanism by which to kill cancer cells. In this minireview, we discuss the benefits that high levels of glycolysis provide for tumor cells, as well as several key enzymes required by cancer cells to maintain this high level of glucose metabolism. It is anticipated that understanding which metabolic enzymes are particularly critical for tumor cell proliferation and survival will identify novel therapeutic targets.
authors.affiliation: Division of Pulmonary and Critical Care, Department of Medicine, Northwestern University Medical School, Chicago, IL 60611, USA.
authors.forename: Robert B
authors.initials: RB
authors.lastname: Hamanaka
authors.forename: Navdeep S
authors.initials: NS
authors.lastname: Chandel
mesh_terms: D053898:Biosynthetic Pathways / Q000502:physiology*; D049109:Cell Proliferation; D002470:Cell Survival / Q000502:physiology*; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D016503:Drug Delivery Systems / Q000379:methods*; D005947:Glucose / Q000378:metabolism*; D006019:Glycolysis / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*
chemical_list: D005947:Glucose