title: Correlation of group C meningococcal conjugate vaccine response with B- and T-lymphocyte activity.
abstract: Despite the success of conjugate vaccination against meningococcal group C (MenC) disease, post-vaccination, some individuals still exhibit rapid waning of initially protective bactericidal antibody levels. The mechanism of this relative loss of humoral protection remains undetermined. In this report we have investigated the relationship between T- and B-cell activation and co-stimulation and the loss of protective antibody titers. We have found that healthy volunteers who lose protective MenC antibody levels one year after receipt of glycoconjugate vaccine exhibit no detectable cellular defect in polyclonal B- or T-cell activation, proliferation or the B-memory pool. This suggests that the processes underlying the more rapid loss of antibody levels are independent of defects in either initial T- or B-cell activation.
authors.affiliation: Department of Infection and Immunity, University of Sheffield Medical School, Sheffield, United Kingdom.
authors.forename: James B
authors.initials: JB
authors.lastname: Wing
authors.forename: Lynne
authors.initials: L
authors.lastname: Smart
authors.forename: Ray
authors.initials: R
authors.lastname: Borrow
authors.forename: Jamie
authors.initials: J
authors.lastname: Findlow
authors.forename: Helen
authors.initials: H
authors.lastname: Findlow
authors.forename: Andrew
authors.initials: A
authors.lastname: Lees
authors.forename: Rachel A
authors.initials: RA
authors.lastname: Foster
authors.forename: Jennifer
authors.initials: J
authors.lastname: Carlring
authors.forename: Robert C
authors.initials: RC
authors.lastname: Read
authors.forename: Andrew W
authors.initials: AW
authors.lastname: Heath
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood; D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D056724:Immunity, Humoral / Q000187:drug effects; D007156:Immunologic Memory; D008213:Lymphocyte Activation; D022401:Meningococcal Vaccines / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D055815:Young Adult
chemical_list: D000907:Antibodies, Bacterial; D022401:Meningococcal Vaccines; C410218:serogroup C meningococcal conjugate vaccine