title: Polymorphisms of the BDNF gene show neither association with multiple sclerosis susceptibility nor clinical course.
abstract: Brain-derived neurotrophic factor (BDNF) has been proposed a protective role in multiple sclerosis (MS) in several studies. The val(66)met polymorphism alters the function of the BDNF protein, and has along with rs56164415 previously been reported to be associated with MS. We genotyped BDNF SNPs val(66)met and rs56164415 in 2149 Norwegian MS patients and 2747 healthy controls. No association was found for any of the SNPs to disease susceptibility or any clinical or demographic parameters including sex, age at onset, disease course, disease severity and cognitive impairment.
authors.affiliation: Department of Neurology, Oslo University Hospital, Ullevål, N-0407 Oslo, Norway. i.l.mero@medisin.uio.no
authors.forename: Inger-Lise
authors.initials: IL
authors.lastname: Mero
authors.forename: Cathrine
authors.initials: C
authors.lastname: Smestad
authors.forename: Benedicte A
authors.initials: BA
authors.lastname: Lie
authors.forename: Åslaug R
authors.initials: ÅR
authors.lastname: Lorentzen
authors.forename: Leiv
authors.initials: L
authors.lastname: Sandvik
authors.forename: Nils Inge
authors.initials: NI
authors.lastname: Landrø
authors.forename: Jan H
authors.initials: JH
authors.lastname: Aarseth
authors.forename: Kjell-Morten
authors.initials: KM
authors.lastname: Myhr
authors.forename: Elisabeth G
authors.initials: EG
authors.lastname: Celius
authors.forename: Hanne F
authors.initials: HF
authors.lastname: Harbo
mesh_terms: D000328:Adult; D017668:Age of Onset; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D018450:Disease Progression; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008715:Methionine / Q000235:genetics; D009103:Multiple Sclerosis / Q000453:epidemiology / Q000235:genetics*; D009664:Norway / Q000453:epidemiology; D011110:Polymorphism, Genetic; D014633:Valine / Q000235:genetics
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D008715:Methionine; D014633:Valine