title: Value of TRAcP 5b as a diagnostic marker for detection of bone metastases in patients with breast cancer.
abstract: OBJECTIVE
  The aim of the study was to test the bone resorption marker TRAcP 5b regarding its suitability for detection of bone metastases in breast cancer patients.
  
  
  METHODS
  Serum samples from a total of 101 patients with histologically proven breast cancer and from 100 healthy probands were analyzed. The patients were divided into three groups: eight patients without osseous involvement, 65 patients with untreated bone metastases, 28 patients whose bone metastases were treated with bisphosphonate therapy.
  
  
  RESULTS
  The TRAcP 5b concentration was significantly higher in breast cancer patients compared to healthy probands. It was not possible to demonstrate a statistically significant difference in the TRAcP 5b concentration if osseous metastases in breast cancer patients were present or not.
  
  
  CONCLUSIONS
  Our research cannot support the claim that TRAcP 5b could be useful as a diagnostic tool for the detection of bone metastases in patients with breast cancer.
authors.affiliation: Depatment of Laboratory Medicine, Internal Medicine, Hospital of the Johann Wolfgang Goethe University, Frankfurt am Main, Germany. martin.hung@gmx.de
authors.forename: M J
authors.initials: MJ
authors.lastname: Hung
authors.forename: G M
authors.initials: GM
authors.lastname: Oremek
mesh_terms: D000135:Acid Phosphatase / Q000032:analysis*; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000556:secondary*; D001943:Breast Neoplasms / Q000737:chemistry / Q000473:pathology*; D002272:Carcinoembryonic Antigen / Q000032:analysis; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D018396:Mucin-1 / Q000097:blood; D012372:ROC Curve; D000071681:Tartrate-Resistant Acid Phosphatase
chemical_list: D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D007527:Isoenzymes; D018396:Mucin-1; C000605510:ACP5 protein, human; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase