title: Induction of DNA double strand breaks in cultured mammalian cells exposed to hydrogen peroxide and histidine.
abstract: The amino acid histidine was found to increase the toxicity of H(2)O(2) in cultured mammalian cells. Histidine also augmented the level of DNA single strand breaks (SSB) detectable in cells exposed to the oxidant and, in addition, resulted in the appearance of DNA double strand breaks (DSB), a lesion which is not produced by H(2)O(2) alone.
authors.affiliation: Istituto di Farmacologia e Farmacognosia and Centro di Farmacologia Oncologica Sperimentale, Università di Urbino, Via S. Chiara, 27, 61029, Urbino, Italy.
authors.forename: O
authors.initials: O
authors.lastname: Cantoni
authors.forename: P
authors.initials: P
authors.lastname: Sestili
authors.forename: F
authors.initials: F
authors.lastname: Cattabeni