title: Slam-associated protein plays a key role in development of autoimmunity.
abstract: In 1995, the SLAM-associated protein (SAP) gene was cloned in our laboratory, and patents were subsequently filed in the USA, EU and Canada. In 1998, the SAP gene was shown to be defective in patients with X-linked lymphoproliferative disease. Since this discovery, the gene has been demonstrated to play a significant role in viral protection, cytokine production and life-long immune memory (vaccination). This article reviews the crucial role of SAP in the development of autoimmunity.
authors.affiliation: Division of Hematology and Rheumatology, Nihon University School of Medicine, Tokyo, Japan. sawada.shigemasa@nihon-u.ac.jp
authors.forename: Shigemasa
authors.initials: S
authors.lastname: Sawada
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000276:immunology / Q000821:virology; D001323:Autoantibodies / Q000276:immunology / Q000378:metabolism; D015551:Autoimmunity / Q000235:genetics / Q000276:immunology*; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D000071179:Signaling Lymphocytic Activation Molecule Associated Protein; D013582:Synovial Fluid / Q000821:virology
chemical_list: D001323:Autoantibodies; D047908:Intracellular Signaling Peptides and Proteins; C114953:SH2D1A protein, human; D000071179:Signaling Lymphocytic Activation Molecule Associated Protein