title: Influence of acute hyperglycemia on otoacoustic emissions and the medial olivocochlear reflex.
abstract: Stimulus-frequency (SF) otoacoustic emission (OAE) amplitude and the amplitude of medial olivocochlear (MOC) inhibition of SF OAEs for ipsilateral, contralateral and bilateral MOC reflex elicitors were recorded in six subjects with type 2 diabetes during a glucose tolerance test (GTT). Five of the six subjects were tested twice for a total of 11 trials and three subjects were tested in a control experiment. During the GTT experiment, the subjects' blood glucose was elevated from a euglycemic level below 150 mg/dL to a hyperglycemic level above 160 mg/dL following the consumption of a bolus of 80 g of sugar. A subset of three subjects were tested in a control experiment during which SF OAE and MOC reflex measurements were made while blood sugar levels remained constant within the euglycemic region. Mean SF OAE amplitudes were elevated following glucose consumption. A statistically significant increase in MOC inhibition amplitude was observed during elevated sugar levels for the 11 GTT trials. Maximum inhibition occurred about an hour after glucose consumption when blood glucose levels peaked. Results indicate that acute hyperglycemia influences efferent control of the cochlea in people with type 2 diabetes.
authors.affiliation: VA RR&D National Center for Rehabilitative Auditory Research, Portland VA Medical Center, 3710 SW U.S. Veterans Hospital Road, Portland, Oregon 97239, USA. peter.jacobs@va.gov
authors.forename: Peter G
authors.initials: PG
authors.lastname: Jacobs
authors.forename: Dawn
authors.initials: D
authors.lastname: Konrad-Martin
authors.forename: Garnett P
authors.initials: GP
authors.lastname: McMillan
authors.forename: Daniel
authors.initials: D
authors.lastname: McDermott
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Fausti
authors.forename: David
authors.initials: D
authors.lastname: Kagen
authors.forename: Eric A
authors.initials: EA
authors.lastname: Wan
mesh_terms: D000161:Acoustic Stimulation; D001300:Audiometry, Evoked Response; D001786:Blood Glucose / Q000378:metabolism; D016022:Case-Control Studies; D003051:Cochlea / Q000502:physiology*; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology*; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009433:Neural Inhibition / Q000502:physiology; D009847:Olivary Nucleus / Q000502:physiology*; D017084:Otoacoustic Emissions, Spontaneous / Q000502:physiology*; D012022:Reflex, Acoustic / Q000502:physiology*
chemical_list: D001786:Blood Glucose