title: Clinical metabolomics paves the way towards future healthcare strategies.
abstract: Metabolomics is recognized as a powerful top-down system biological approach to understand genetic-environment-health paradigms paving new avenues to identify clinically relevant biomarkers. It is nowadays commonly used in clinical applications shedding new light on physiological regulatory processes of complex mammalian systems with regard to disease aetiology, diagnostic stratification and, potentially, mechanism of action of therapeutic solutions. A key feature of metabolomics lies in its ability to underpin the complex metabolic interactions of the host with its commensal microbial partners providing a new way to define individual and population phenotypes. This review aims at describing recent applications of metabolomics in clinical fields with insight into diseases, diagnostics/monitoring and improvement of homeostatic metabolic regulation.
authors.affiliation: Nestec Ltd, Nestlé Research Center, BioAnalytical Science, Metabolomics and Biomarkers, PO Box 44, CH-1000 Lausanne 26, Switzerland.
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Collino
authors.forename: François-Pierre J
authors.initials: FP
authors.lastname: Martin
authors.forename: Serge
authors.initials: S
authors.lastname: Rezzi
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D035843:Biomedical Research / Q000379:methods* / Q000639:trends; D003695:Delivery of Health Care / Q000379:methods* / Q000639:trends; D019468:Disease Management; D006801:Humans; D055432:Metabolomics / Q000379:methods* / Q000639:trends; D023421:Models, Animal
chemical_list: D015415:Biomarkers