title: Differential expression of Kv1.3 and Kv1.5 voltage-dependent K+ channels in human skeletal muscle sarcomas.
abstract: Because Kv1.3 and Kv1.5 K(+) channels are remodeled during tumorigenesis and participate in skeletal muscle proliferation, we analyzed their expression in human skeletal muscle sarcomas. Aggressive alveolar rhabdomyosarcoma (ARMS) and embryonal rhabdomyosarcoma (ERMS) were studied. Kv1.5 expression was moderate in adult muscle and low in ERMS, whereas it was notable in ARMS and embryonic samples. Kv1.3 expression showed no major differences between RMS and healthy samples. We found a correlation of Kv1.3 and Kv1.5 expression with the tumor malignancy.
authors.affiliation: Molecular Physiology Laboratory, Departament de Bioquímica i Biologia Molecular, Institut de Biomedicina, Universitat de Barcelona, Spain.
authors.forename: Joanna
authors.initials: J
authors.lastname: Bielanska
authors.forename: Javier
authors.initials: J
authors.lastname: Hernández-Losa
authors.forename: Teresa
authors.initials: T
authors.lastname: Moline
authors.forename: Rosa
authors.initials: R
authors.lastname: Somoza
authors.forename: Santiago
authors.initials: S
authors.lastname: Ramón y Cajal
authors.forename: Enric
authors.initials: E
authors.lastname: Condom
authors.forename: Joan Carles
authors.initials: JC
authors.lastname: Ferreres
authors.forename: Antonio
authors.initials: A
authors.lastname: Felipe
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D016193:G1 Phase; D006801:Humans; D007150:Immunohistochemistry; D051664:Kv1.3 Potassium Channel / Q000032:analysis* / Q000502:physiology; D051666:Kv1.5 Potassium Channel / Q000032:analysis* / Q000502:physiology; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000473:pathology*; D012208:Rhabdomyosarcoma / Q000378:metabolism* / Q000473:pathology
chemical_list: C496981:KCNA5 protein, human; D051664:Kv1.3 Potassium Channel; D051666:Kv1.5 Potassium Channel