title: CD4/CD8 dual-positive mycosis fungoides: a previously unrecognized variant.
abstract: Mycosis fungoides (MF) is a primary cutaneous lymphoma characterized by atypical T-lymphocytes that usually presents as patches and plaques on photoprotected areas of the body, such as the groin and buttocks. Classically, the atypical lymphocytes in MF are CD3/CD4 positive with loss of CD7 and less often loss of CD5. In a minority of cases, the atypical infiltrate is CD8 positive. We report a case of biopsy-proven MF in an elderly woman who presented with sclerodermoid lesions on her abdomen and thigh. Immunohistochemical studies revealed coexpression of CD4 and CD8 in a subset of atypical T-lymphocytes, and this was confirmed with flow cytometry. To our knowledge, this is the first report of a CD4/CD8 dual-positive MF.
authors.affiliation: University of South Florida College of Medicine, Tampa, FL, USA. cknapp@health.usf.edu
authors.forename: Charles F
authors.initials: CF
authors.lastname: Knapp
authors.forename: Rahel
authors.initials: R
authors.lastname: Mathew
authors.forename: Jane L
authors.initials: JL
authors.lastname: Messina
authors.forename: Mary H
authors.initials: MH
authors.lastname: Lien
mesh_terms: D000368:Aged; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D003131:Combined Modality Therapy; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D009182:Mycosis Fungoides / Q000276:immunology / Q000473:pathology* / Q000628:therapy; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology* / Q000628:therapy; D016896:Treatment Outcome