title: Expression of IGF-1R, VEGF-C and D2-40 and their correlation with lymph node metastasis in endometrial adenocarcinoma.
abstract: Insulin-like growth factor-1 receptor (IGF-1R) regulates carcinogenesis and tumor development and is expressed in normal endometrium. Vascular endothelial growth factor C (VEGF-C) promotes lymph node metastasis. We investigated IGF-1R, VEGF-C and D2-40 in endometrial adenocarcinoma and the association between IGF-1R and lymphatic metastasis, using an immunohistochemical S-P method with 40 cases of endometrial adenocarcinoma and 14 of normal endometrium. IGF-1R expression differed significantly between normal endometrium and adenocarcinoma; it was associated with histological grade but not surgical stage. IGF-1R overexpression was associated with metastasis, but expression was not. VEGF-C expression was greater in normal endometrium than in adenocarcinoma and was associated with metastasis but not with surgical stage or histological grade. IGF-IR and VEGF-C expression were correlated in endometrial adenocarcinoma, and lymphatic vessel density was closely related to both. Abnormal IGF-IR and VEGF-C expression may be important in lymph node metastasis of endometrial adenocarcinoma and might be used to evaluate the prognosis.
authors.affiliation: Department of Gynecology and Obstetrics, First Affiliated Hospital of Henan University of Science and Technology, Hospital, Luoyang, China. wan_baobei@163.com
authors.forename: H
authors.initials: H
authors.lastname: Pengchong
authors.forename: H
authors.initials: H
authors.lastname: Tao
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry / Q000473:pathology*; D058846:Antibodies, Monoclonal, Murine-Derived / Q000032:analysis*; D016889:Endometrial Neoplasms / Q000737:chemistry / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D042601:Lymphatic Vessels / Q000737:chemistry*; D017526:Receptor, IGF Type 1 / Q000032:analysis*; D042582:Vascular Endothelial Growth Factor C / Q000032:analysis*
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D042582:Vascular Endothelial Growth Factor C; C500987:monoclonal antibody D2-40; D017526:Receptor, IGF Type 1