title: Dress syndrome with sepsis, acute respiratory distress syndrome and pneumomediastinum.
abstract: Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome reflects a serious hypersensitivity reaction to drugs, and is characterized by skin rash, fever, lymph node enlargement, and internal organ involvement. So far, numerous drugs such as sulfonamides, phenobarbital, sulfasalazine, carbamazepine, and phenytoin have been reported to cause DRESS syndrome. We report a case of a 10-year-old girl who developed clinical manifestations of fever, rash, lymphadenopathy, hypereosinophilia, and visceral involvement (hepatitis and pneumonitis) after taking phenobarbital for seizures, with subsequent development of sepsis, acute respiratory distress syndrome (ARDS) and spontaneous air leak syndrome (pnemothorax and pneumomediastinum). She was put on steroids and various antibiotics and was ventilated, but ultimately succumbed to sepsis and pulmonary complications.
authors.affiliation: Department of Pediatric Medicine, Institute of Child Health, Kolkata, India .
authors.forename: Prabhas Prasun
authors.initials: PP
authors.lastname: Giri
authors.forename: Swapan
authors.initials: S
authors.lastname: Roy
authors.forename: Sukanta
authors.initials: S
authors.lastname: Bhattyacharya
authors.forename: Priyankar
authors.initials: P
authors.lastname: Pal
authors.forename: Sandipan
authors.initials: S
authors.lastname: Dhar