title: Fulminant hepatic failure caused by adenovirus infection mimicking peliosis hepatitis on abdominal computed tomography images after allogeneic hematopoietic stem cell transplantation.
abstract: Disseminated adenovirus disease after allogeneic hematopoietic stem cell transplantation (HSCT) is lethal in most cases, especially when it develops as fulminant hepatic failure. We encountered a patient who developed fulminant hepatic failure caused by adenovirus infection. She did not show manifestations of graft-versus-host disease and the results of serum tests for viral infection were all negative. Abdominal computed tomography (CT) findings were consistent with peliosis hepatitis. She died of fulminant hepatic failure, however, and pathological examinations of the liver specimen obtained after her death revealed adenovirus infection. In this report, we review the clinical characteristics and imaging findings of fulminant hepatic failure caused by adenovirus infection.
authors.affiliation: Division of Hematology, Saitama Medical Center, Jichi Medical University, Japan.
authors.forename: Kiriko
authors.initials: K
authors.lastname: Terasako
authors.forename: Kumi
authors.initials: K
authors.lastname: Oshima
authors.forename: Hidenori
authors.initials: H
authors.lastname: Wada
authors.forename: Yuko
authors.initials: Y
authors.lastname: Ishihara
authors.forename: Koji
authors.initials: K
authors.lastname: Kawamura
authors.forename: Kana
authors.initials: K
authors.lastname: Sakamoto
authors.forename: Masahiro
authors.initials: M
authors.lastname: Ashizawa
authors.forename: Miki
authors.initials: M
authors.lastname: Sato
authors.forename: Tomohito
authors.initials: T
authors.lastname: Machishima
authors.forename: Hideki
authors.initials: H
authors.lastname: Nakasone
authors.forename: Shun-ichi
authors.initials: S
authors.lastname: Kimura
authors.forename: Misato
authors.initials: M
authors.lastname: Kikuchi
authors.forename: Shinya
authors.initials: S
authors.lastname: Okuda
authors.forename: Shinichi
authors.initials: S
authors.lastname: Kako
authors.forename: Rie
authors.initials: R
authors.lastname: Yamazaki
authors.forename: Kengo
authors.initials: K
authors.lastname: Takeuchi
authors.forename: Junji
authors.initials: J
authors.lastname: Nishida
authors.forename: Shigeki
authors.initials: S
authors.lastname: Yamada
authors.forename: Osamu
authors.initials: O
authors.lastname: Tanaka
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Kanda
mesh_terms: D000258:Adenovirus Infections, Human / Q000150:complications*; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008099:Liver / Q000473:pathology* / Q000821:virology; D017114:Liver Failure, Acute / Q000000981:diagnostic imaging* / Q000473:pathology / Q000821:virology; D008875:Middle Aged; D010382:Peliosis Hepatis / Q000000981:diagnostic imaging*; D011860:Radiography, Abdominal; D014057:Tomography, X-Ray Computed; D014184:Transplantation, Homologous