title: Ischemia modified albumin and carbonyl protein as potential biomarkers of protein oxidation in hemodialysis.
abstract: OBJECTIVE
  The aim of this study was to evaluate the effect of HD on ischemia modified albumin (IMA) and protein carbonyl groups in order to investigate the role of IMA as a marker of protein oxidation.
  
  
  METHODS
  This study was conducted with 23 chronic hemodialysis patients. The serum IMA levels and protein carbonyl groups were measured immediately before hemodialysis (pre-HD) and after the end of hemodialysis (post-HD).
  
  
  RESULTS
  IMA concentrations were significantly higher in post-HD than those of the pre-HD and carbonyl protein concentrations were higher in post-HD in comparison with pre-HD. A significant correlation was observed between IMA and carbonyl protein levels.
  
  
  CONCLUSIONS
  The increase of IMA levels and protein carbonyl groups post-HD could be attributed to the increase of oxidative stress associated with HD, and IMA appears to be an important biomarker for assessing protein oxidation after HD.
authors.affiliation: Programa de Pós-Graduação em Hematologia e Hemoterapia, Centro de Ciências Biológicas, Universidade de Passo Fundo, Passo Fundo, RS, Brazil.
authors.forename: Kassiano
authors.initials: K
authors.lastname: Albarello
authors.forename: Gélson Antônio
authors.initials: GA
authors.lastname: dos Santos
authors.forename: Guilherme Vargas
authors.initials: GV
authors.lastname: Bochi
authors.forename: Manuela Borges
authors.initials: MB
authors.lastname: Sangoi
authors.forename: Taís Corrêa
authors.initials: TC
authors.lastname: Almeida
authors.forename: José Edson
authors.initials: JE
authors.lastname: Paz da Silva
authors.forename: Solange Cristina
authors.initials: SC
authors.lastname: Garcia
authors.forename: Rafael Noal
authors.initials: RN
authors.lastname: Moresco
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000378:metabolism / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D050050:Protein Carbonylation; D006435:Renal Dialysis; D012709:Serum Albumin / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D012709:Serum Albumin