title: Dilated cardiomyopathy in two patients with xeroderma pigmentosum disease: a case report.
abstract: Xeroderma pigmentosum (XP), is an autosomal recessive genetic disorder of DNA repair in which the ability to repair damage caused by ultraviolet (UV) light is deficient. The oxidative stress caused by decline catalase activity as an antioxidant enzyme, has been illustrated in these patients. This is the first case report of dilated cardiomyopathy in two patients with XP, A 26 year old girl and her younger brother. Laboratory studies demonstrated severe vitamin D deficiency in both of them. Cardiac dysfunction in the presented cases with XP might be caused by vitamin D deficiency. But this question still remains: whether chronic oxidative stress can involve the heart and can be a predisposing factor or even an underlying factor for dilated cardiomyopathy in XP, or not. More studies are needed for demonstrating this hypothesis.
authors.affiliation: Department of Cardiology, Rasul-e-AkramHospital, Tehran University of Medical Sciences, Iran. hajsadeghi.shokoufeh@yahoo.com
authors.forename: Shokoufeh
authors.initials: S
authors.lastname: Hajsadeghi
authors.forename: Maral
authors.initials: M
authors.lastname: Hejrati
authors.forename: Samar
authors.initials: S
authors.lastname: Moghadami
authors.forename: Sahar
authors.initials: S
authors.lastname: Rismantab
authors.forename: Parva
authors.initials: P
authors.lastname: Namiranian
mesh_terms: D000328:Adult; D002311:Cardiomyopathy, Dilated / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D014983:Xeroderma Pigmentosum / Q000150:complications*