title: Developmental profiles of infant EEG: overlap with transient cortical circuits.
abstract: OBJECTIVE
  To quantify spectral power in frequency specific bands and commonly observed types of bursting activities in the EEG during early human development.
  
  
  METHODS
  An extensive archive of EEG data from human infants from 35 to 52 weeks postmenstrual age obtained in a prior multi-center study was analyzed using power spectrum analyses and a high frequency burst detection algorithm.
  
  
  RESULTS
  Low frequency power increased with age; however, high frequency power decreased from 35 to 45 weeks. This unexpected decrease was largely attributable to a rapid decline in the number of high frequency bursts.
  
  
  CONCLUSIONS
  The decline in high frequency bursting activity overlaps with a developmental shift in GABA's actions on neurons from depolarizing to hyperpolarizing and the dissolution of the gap junction circuitry of the cortical subplate.
  
  
  CONCLUSIONS
  We postulate that quantitative characterization of features of the EEG unique to early development provide indices for tracking changes in specific neurophysiologic mechanisms that are critical for normal development of brain function.
authors.affiliation: Department of Psychiatry, Columbia University, New York, NY 10032 United States. mmm3@columbia.edu
authors.forename: M M
authors.initials: MM
authors.lastname: Myers
authors.forename: P G
authors.initials: PG
authors.lastname: Grieve
authors.forename: A
authors.initials: A
authors.lastname: Izraelit
authors.forename: W P
authors.initials: WP
authors.lastname: Fifer
authors.forename: J R
authors.initials: JR
authors.lastname: Isler
authors.forename: R A
authors.initials: RA
authors.lastname: Darnall
authors.forename: R I
authors.initials: RI
authors.lastname: Stark
mesh_terms: D000465:Algorithms; D001921:Brain / Q000254:growth & development / Q000502:physiology*; D058256:Brain Waves / Q000502:physiology*; D002540:Cerebral Cortex / Q000502:physiology*; D002657:Child Development / Q000502:physiology*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D008297:Male; D017286:Polysomnography