title: Secondary healing after removal of large keratocystic odontogenic tumor in the mandible: enucleation followed by open packing of iodoform gauze.
abstract: OBJECTIVE
  The aim of this retrospective study was to present the findings of an open packing method after enucleation of large keratocystic odontogenic tumors (KCOTs) in the mandible.
  
  
  METHODS
  We performed a retrospective case series study of 27 patients with KCOTs larger than 5 cm treated at our institution between September 2003 and September 2008. A conservative surgical treatment was applied, which involved enucleation of the primary lesion and open packing of the residual osseous defect with iodoform gauze for secondary healing. Bone regeneration, tumor recurrence, and surgical complications were observed and analyzed. We used the χ(2) test and Pearson correlation coefficient for statistical analysis.
  
  
  RESULTS
  The postoperative follow-up time was 52.3 months on average (range, 24 to 84 months). The packing gauze was changed every 2 weeks after enucleation, and the total duration for packing was 10.2 months on average (range, 7-15 months). Bone regeneration and satisfactory secondary healing were observed clinically and radiographically after treatment. Only 1 case had a recurrence 6 months after initial treatment, which was attributed to insufficient bony unroofing during enucleation. The recurrent lesion was re-treated by the same method, and no recurrence occurred in the following 6 years. No serious complications from this method of treatment were observed. No significant variables were found to be related to the recurrence.
  
  
  CONCLUSIONS
  Enucleation with subsequent open packing was shown to be a conservative and comfortable treatment for patients and appears to be an effective choice for the management of large KCOTs in the mandible.
authors.affiliation: Department of Oral and Maxillofacial Surgery, School of Stomatology, Fourth Military Medical University, Xi'an, China. hz_zhou@yahoo.com
authors.forename: Hongzhi
authors.initials: H
authors.lastname: Zhou
authors.forename: Rui
authors.initials: R
authors.lastname: Hou
authors.forename: Qin
authors.initials: Q
authors.lastname: Ma
authors.forename: Kenneth
authors.initials: K
authors.lastname: Wu
authors.forename: Yuxiang
authors.initials: Y
authors.lastname: Ding
authors.forename: Ruifeng
authors.initials: R
authors.lastname: Qin
authors.forename: Kaijin
authors.initials: K
authors.lastname: Hu
mesh_terms: D000293:Adolescent; D000328:Adult; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D001861:Bone Regeneration / Q000502:physiology; D002648:Child; D003475:Curettage / Q000379:methods; D004848:Epithelium / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006097:Granulation Tissue / Q000473:pathology; D006801:Humans; D006847:Hydrocarbons, Iodinated / Q000627:therapeutic use*; D008297:Male; D008339:Mandibular Neoplasms / Q000601:surgery*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000601:surgery; D009808:Odontogenic Tumors / Q000601:surgery*; D010027:Osteotomy / Q000379:methods; D010147:Pain Measurement; D010149:Postoperative Pain / Q000209:etiology; D011183:Postoperative Complications; D011862:Radiography, Panoramic; D012189:Retrospective Studies; D013630:Tampons, Surgical; D016896:Treatment Outcome; D014945:Wound Healing / Q000502:physiology; D055815:Young Adult
chemical_list: D000891:Anti-Infective Agents, Local; D006847:Hydrocarbons, Iodinated; C010473:iodoform