title: Mucin phenotypes and macroscopic shape of multiple hyperplastic polyps together with two carcinomas in the stomach.
abstract: The patient was a 57-year-old Japanese woman who had been identified as having anemia and hypoproteinemia by a local group medical check-up. Esophagogastroduodenoscopy revealed an elevated lesion of 35mm in diameter on the posterior wall of the gastric antrum, surrounded by multiple polyps. The elevated lesion was diagnosed as an adenocarcinoma on the basis of biopsy, and total gastrectomy was performed. Histological examination of entire resected stomach revealed two lesions of intramucosal carcinoma together with multiple hyperplastic polyps. To investigate the mucin phenotypes and carcinogenesis of these lesions, immunohistochemical analyses of MUC2, MUC5AC, MUC6, CD10, Ki-67 and p53 protein expressions were performed in 17 hyperplastic polyps and two cancerous lesions. Expression of the MUC6 positive glands beneath the surface foveolar epithelium of hyperplastic polyps caused a morphological change from sessile to pedunculated, suggesting that this was also involved with cancerous changes. The case reported herein seems to be extremely interesting in terms of elucidating the process whereby gastric cancer arises from hyperplastic polyps.
authors.affiliation: Department of Gastroenterology, Tokyo Rosai Hospital, Tokyo, Japan. ymizuguc@tokyoh.rofuku.go.jp
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Mizuguchi
authors.forename: Kazuo
authors.initials: K
authors.lastname: Takei
authors.forename: Jun
authors.initials: J
authors.lastname: Matsubayashi
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Kojima
authors.forename: Shuuta
authors.initials: S
authors.lastname: Nisinakagawa
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Oba
authors.forename: Takashi
authors.initials: T
authors.lastname: Kawai
authors.forename: Fuminori
authors.initials: F
authors.lastname: Moriyasu
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry* / Q000473:pathology* / Q000601:surgery; D014408:Biomarkers, Tumor / Q000032:analysis*; D001706:Biopsy; D005260:Female; D005743:Gastrectomy; D005752:Gastric Mucins / Q000032:analysis*; D005773:Gastroscopy; D006801:Humans; D006965:Hyperplasia; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis; D008875:Middle Aged; D055271:Mucin 5AC / Q000032:analysis; D055262:Mucin-2 / Q000032:analysis; D055272:Mucin-6 / Q000032:analysis; D009378:Neoplasms, Multiple Primary / Q000737:chemistry* / Q000473:pathology* / Q000601:surgery; D015260:Neprilysin / Q000032:analysis; D010641:Phenotype; D011127:Polyps / Q000737:chemistry* / Q000473:pathology* / Q000601:surgery; D016159:Tumor Suppressor Protein p53 / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D005752:Gastric Mucins; D019394:Ki-67 Antigen; C524625:MUC2 protein, human; C524678:MUC5AC protein, human; C524734:MUC6 protein, human; D055271:Mucin 5AC; D055262:Mucin-2; D055272:Mucin-6; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53; D015260:Neprilysin