title: [Comparative characteristics of glucose metabolism in the liver of rats under acute alcohol and morphine intoxication].
abstract: The comparative analysis effect of acute alcohol and morphine intoxications on rats on hepatic glycolysis and pentose phosphate pathway was done. The dose-dependent inhibitory effect of ethanol on activity of limiting enzymes of these metabolic ways, as well as anaerobic reorientation of glucose metabolism was recognised with the increase of the dose of the intake alcohol. Morfine (10 mg/kg) activated enymes of glycolysis and pentose phosphate pathway, but in contrast to ethanol it did not influence these parameters at the dose 20 or 40 mg/kg.
authors.forename: S V
authors.initials: SV
authors.lastname: Lelevich
mesh_terms: D000208:Acute Disease; D000435:Alcoholic Intoxication / Q000201:enzymology / Q000378:metabolism*; D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000633:toxicity; D005947:Glucose / Q000378:metabolism*; D006019:Glycolysis / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D009020:Morphine / Q000633:toxicity; D009021:Morphine Dependence / Q000201:enzymology / Q000378:metabolism*; D010427:Pentose Phosphate Pathway / Q000187:drug effects*; D051381:Rats
chemical_list: D000431:Ethanol; D009020:Morphine; D005947:Glucose