title: [Analysis of cardiotoxicity of chemotherapy in 30 cases with gynecological cancer].
abstract: OBJECTIVE
  To investigate the occurrence of cardiotoxicity of chemotherapeutic drugs in gynecological cancer patients without heart disease, and patients with coronary heart disease or congenital heart disease for providing a basis for the clinical prevention of heart side effects during chemotherapy.
  
  
  METHODS
  Thirty cases with gynecological cancer complication with or without coronary heart disease or congenital heart disease before or during chemotherapy admitted from Jan.2004 to Dec.2010 were retrospectively analyzed.
  
  
  RESULTS
  For all 30 patients, there were heart failures in 3 cases (10%, 3/30), myocardial infarction in 3 cases (10%, 3/30), angina pectoris in 1 cases (3%, 1/30), ST-T or T-wave changes in 9 cases (30%, 9/30), and arrhythmia in 8 cases (27%, 8/30).
  
  
  CONCLUSIONS
  Cancer chemotherapy drugs to the heart may produce an immediate or long-term toxicity, in which could significantly effects on the survival and prognosis of patients. It is very important to prevent the occurrence of cardiotoxicity of chemotherapeutic drugs in gynecological cancer patients with heart diseases during chemotherapy.
authors.affiliation: Department of Gynecology, Peking University People's Hospital, Beijing, China.
authors.forename: Bing-jie
authors.initials: BJ
authors.lastname: Liu
authors.forename: Xiao-ping
authors.initials: XP
authors.lastname: Li
authors.forename: Jian-liu
authors.initials: JL
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Wu
authors.forename: Li-hui
authors.initials: LH
authors.lastname: Wei
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000633:toxicity*; D066126:Cardiotoxicity / Q000209:etiology* / Q000517:prevention & control; D016022:Case-Control Studies; D005260:Female; D005833:Genital Neoplasms, Female / Q000188:drug therapy*; D006321:Heart / Q000187:drug effects*; D006331:Heart Diseases / Q000139:chemically induced*; D006801:Humans; D008875:Middle Aged; D009203:Myocardial Infarction; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D000970:Antineoplastic Agents