title: Anti-ganglioside antibodies were not detected in human subjects infected with or vaccinated against 2009 pandemic influenza A (H1N1) virus.
abstract: Recipients of influenza A (H1N1) vaccine in 1976 had an increased risk for the neurologic disorder Guillain-Barré syndrome (GBS). Anti-ganglioside antibodies, which might be associated with the development of GBS, were previously reported to be induced in mice immunized with an H1N1 vaccine of 1976 or another influenza vaccine. In this study we analyzed anti-ganglioside antibodies in human subjects infected with or vaccinated against 2009 pandemic H1N1, including eight patients diagnosed to have post-vaccination GBS. Antibodies against GM1 or another ganglioside were not detected in any subject or in vaccinated mice. Our results did not support the induction of anti-ganglioside antibodies by influenza viruses or vaccines.
authors.affiliation: Department of Pathology, School of Medicine, Xi'an Jiaotong University, Xi'an, China.
authors.forename: Ting
authors.initials: T
authors.lastname: Lei
authors.forename: Kam-Leung
authors.initials: KL
authors.lastname: Siu
authors.forename: Kin-Hang
authors.initials: KH
authors.lastname: Kok
authors.forename: Kwok-Hung
authors.initials: KH
authors.lastname: Chan
authors.forename: Eric Y T
authors.initials: EY
authors.lastname: Chan
authors.forename: Ivan F N
authors.initials: IF
authors.lastname: Hung
authors.forename: Kelvin K W
authors.initials: KK
authors.lastname: To
authors.forename: Patrick C K
authors.initials: PC
authors.lastname: Li
authors.forename: Jie
authors.initials: J
authors.lastname: Zhou
authors.forename: Bo-Jian
authors.initials: BJ
authors.lastname: Zheng
authors.forename: Kwok-Yung
authors.initials: KY
authors.lastname: Yuen
authors.forename: Ming
authors.initials: M
authors.lastname: Wang
authors.forename: Dong-Yan
authors.initials: DY
authors.lastname: Jin
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology; D005260:Female; D005732:Gangliosides / Q000097:blood / Q000276:immunology*; D020275:Guillain-Barre Syndrome / Q000453:epidemiology / Q000209:etiology / Q000276:immunology*; D006385:Hemagglutination Inhibition Tests; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology*; D007252:Influenza Vaccines / Q000009:adverse effects / Q000276:immunology*; D007251:Influenza, Human / Q000453:epidemiology / Q000276:immunology* / Q000517:prevention & control; D051379:Mice; D008810:Mice, Inbred C57BL; D058873:Pandemics; D014611:Vaccination; D015164:Vaccines, Inactivated
chemical_list: D001323:Autoantibodies; D005732:Gangliosides; D007252:Influenza Vaccines; D015164:Vaccines, Inactivated