title: Synthesis of DNA interstrand cross-links using a photocaged nucleobase.
abstract: The missing linking: BCNU is a chemotherapy drug that generates an ethylene bridge between N(1) of deoxyguanosine and N(3) of deoxycytidine. No synthesis of a DNA containing this moiety has been reported until now. A new strategy uses a photocaged nucleobase that, when released, generates a highly reactive intermediate which cross-links the opposing DNA strand in a manner analogous to BCNU.
authors.affiliation: Institute of Organic Chemistry, University of Zurich, Switzerland.
authors.forename: Sarah
authors.initials: S
authors.lastname: Hentschel
authors.forename: Jawad
authors.initials: J
authors.lastname: Alzeer
authors.forename: Todor
authors.initials: T
authors.lastname: Angelov
authors.forename: Orlando D
authors.initials: OD
authors.lastname: Schärer
authors.forename: Nathan W
authors.initials: NW
authors.lastname: Luedtke
mesh_terms: D000478:Alkylation; D002330:Carmustine / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D003841:Deoxycytidine / Q000737:chemistry; D003849:Deoxyguanosine / Q000737:chemistry
chemical_list: D003432:Cross-Linking Reagents; D003841:Deoxycytidine; D004247:DNA; D003849:Deoxyguanosine; D002330:Carmustine