title: Role of bone marrow-derived mesenchymal stem cells in the prevention of hyperoxia-induced lung injury in newborn mice.
abstract: BPD (bronchopulmonary dysplasia) is predominantly characterized by persistent abnormalities in lung structure and arrested lung development, but therapy can be palliative. While promising, the use of BMSC (bone marrow-derived mesenchymal stem cell) in the treatment of lung diseases remains controversial. We have assessed the therapeutic effects of BMSC in vitro and in vivo. In vitro co-culturing with injured lung tissue increased the migration-potential of BMSC; and SP-C (surfactant protein-C), a specific marker of AEC2 (type II alveolar epithelial cells), was expressed. Following intraperitoneal injection of BMSC into experimental BPD mice on post-natal day 7, it was found that BMSC can home to the injured lung, express SP-C, improve pulmonary architecture, attenuate pulmonary fibrosis and increase the survival rate of BPD mice. This work supports the notion that BMSC are of therapeutic benefit through the production of soluble factors at bioactive levels that regulate the pathogenesis of inflammation and fibrosis following hyperoxia.
authors.affiliation: Department of Pediatrics, BaYi Childrens Hospital of The General Military Hospital of Beijing PLA, Beijing 100700, Peoples Republic of China. xiaoyingzhang79@163.com
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Zhang
authors.forename: Hui
authors.initials: H
authors.lastname: Wang
authors.forename: Yun
authors.initials: Y
authors.lastname: Shi
authors.forename: Wei
authors.initials: W
authors.lastname: Peng
authors.forename: Sheng
authors.initials: S
authors.lastname: Zhang
authors.forename: Wanqiao
authors.initials: W
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Xu
authors.forename: Yabo
authors.initials: Y
authors.lastname: Mei
authors.forename: Zhichun
authors.initials: Z
authors.lastname: Feng
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001854:Bone Marrow Cells / Q000378:metabolism / Q000502:physiology*; D001997:Bronchopulmonary Dysplasia / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D002454:Cell Differentiation; D002465:Cell Movement; D048430:Cell Shape; D002478:Cells, Cultured; D018920:Coculture Techniques; D004195:Disease Models, Animal; D005260:Female; D005355:Fibrosis; D006801:Humans; D018496:Hyperoxia / Q000150:complications*; D007231:Infant, Newborn; D007274:Injections, Intraperitoneal; D008168:Lung / Q000473:pathology; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000378:metabolism / Q000502:physiology*; D051379:Mice; D011014:Pneumonia / Q000209:etiology / Q000517:prevention & control