title: [Treatment of langerhans cell histiocytosis in children].
abstract: Langerhans' cell histiocytosis (LCH) is a disease characterised by pathologic accumulation and proliferation of histiocytes, cells from the monocyte-macrophage system, in various tissues and organs. In this retrospective study we analyzed patients charts treated in the Department of pediatric hematology and oncology at the University Hospital Zagreb with the diagnosis of LCH. Twenty-two children were diagnosed between January 1st 1996 and December 31st 2010, and all were treated with chemotherapy. 19 patients survived (86%) and the remaining 3 (14%), all under the age of 2 with multisystem disease, died. At the time of diagnosis 12 children (55%) presented with single-system disease, the most common were bone lesions in 8 children (36%). All children were treated according to protocols LCH-I and LCH -III. Eight children had mild complications of treatment and the disease itself. Diabetes insipidus remains in 4 children.
authors.affiliation: Klinika za pedijatriju Medicinskog fakulteta Sveuclista u Zagrebu, KBC Zagreb. ernest.bilic@zg.t-com.hr
authors.forename: Ernest
authors.initials: E
authors.lastname: Bilić
authors.forename: Katarina
authors.initials: K
authors.lastname: Bojanić
authors.forename: Maja
authors.initials: M
authors.lastname: Pavlović
authors.forename: Josip
authors.initials: J
authors.lastname: Konja
authors.forename: Ranka
authors.initials: R
authors.lastname: Femenić
authors.forename: Tomislav
authors.initials: T
authors.lastname: Dapić
authors.forename: Anko
authors.initials: A
authors.lastname: Antabak
authors.forename: Darko
authors.initials: D
authors.lastname: Anticević
authors.forename: Slobodna
authors.initials: S
authors.lastname: Murat-Susić
authors.forename: Karmela
authors.initials: K
authors.lastname: Husar
authors.forename: Kristina
authors.initials: K
authors.lastname: Potocki
authors.forename: Ljubica
authors.initials: L
authors.lastname: Rajić
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007223:Infant; D008297:Male