title: A new era for castrate resistant prostate cancer: a treatment review and update.
abstract: OBJECTIVE
  The purpose of this review article is to present the current treatment options for castrate resistant prostate cancer in addition to the recently approved agents and their role in treatment.
  
  
  CONCLUSIONS
  The biology of prostate cancer and the data supporting the use of traditional chemotherapeutic options in castrate resistant prostate cancer are reviewed. The newly approved agents, sipuleucel-T, cabazitaxel, and abiraterone, are presented as well. The studies that led to the approval of these three agents are discussed in this article as well as their current and potential roles in the treatment of castrate resistant prostate cancer.
  
  
  CONCLUSIONS
  New mechanisms, drugs, and clinically relevant molecular targets show survival advantage and are new options available for patients after traditional chemotherapy. The roles of these new agents have yet to be further clarified in future studies.
authors.affiliation: Roswell Park Cancer Institute, Buffalo, NY 14263, USA. Meika.Fong@RoswellPark.org
authors.forename: Mei Ka
authors.initials: MK
authors.lastname: Fong
authors.forename: Ryan
authors.initials: R
authors.lastname: Hare
authors.forename: Anthony
authors.initials: A
authors.lastname: Jarkowski
mesh_terms: D000736:Androstenes; D000737:Androstenols / Q000627:therapeutic use; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D017277:Drug Approval; D006801:Humans; D008297:Male; D058990:Molecular Targeted Therapy; D009919:Orchiectomy; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D015996:Survival Rate; D043823:Taxoids / Q000627:therapeutic use; D014020:Tissue Extracts / Q000627:therapeutic use; D014481:United States; D014486:United States Food and Drug Administration
chemical_list: D000736:Androstenes; D000737:Androstenols; D000970:Antineoplastic Agents; D043823:Taxoids; D014020:Tissue Extracts; C552428:cabazitaxel; C511774:sipuleucel-T; C089740:abiraterone