title: Cycloartane and friedelane triterpenoids from the leaves of Caloncoba glauca and their evaluation for inhibition of 11β-hydroxysteroid dehydrogenases.
abstract: Five new triterpenoids, caloncobic acids A and B (1 and 2), caloncobalactones A and B (3 and 4), and glaucalactone (5), along with the known compounds 3β,21β-dihydroxy-30-nor-(D:A)-friedo-olean-20(29)-en-27-oic acid (6) and acetyltrichadenic acid B (7), were isolated from the leaves of Caloncoba glauca. The structures of 1-5 were elucidated using spectroscopic methods. Compounds 1-7 were evaluated for their inhibitory activities against two isozymes of 11β-hydroxysteroid dehydrogenase (11β-HSD1 and 11β-HSD2). Compounds 1 and 2 exhibited strong inhibitory activities against mouse (EC(50) 132 and 13 nM) and human (EC(50) 105 and 72 nM) 11β-HSD1.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China.
authors.forename: James D Simo
authors.initials: JD
authors.lastname: Mpetga
authors.forename: Yu
authors.initials: Y
authors.lastname: Shen
authors.forename: Pierre
authors.initials: P
authors.lastname: Tane
authors.forename: Shi-Fei
authors.initials: SF
authors.lastname: Li
authors.forename: Hong-Ping
authors.initials: HP
authors.lastname: He
authors.forename: Hippolyte K
authors.initials: HK
authors.lastname: Wabo
authors.forename: Mathieu
authors.initials: M
authors.lastname: Tene
authors.forename: Ying
authors.initials: Y
authors.lastname: Leng
authors.forename: Xiao-Jiang
authors.initials: XJ
authors.lastname: Hao
mesh_terms: D042842:11-beta-Hydroxysteroid Dehydrogenases / Q000378:metabolism*; D000818:Animals; D002163:Cameroon; D006801:Humans; D051379:Mice; D018515:Plant Leaves / Q000737:chemistry; D031308:Salicaceae / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D014315:Triterpenes; C421805:friedelane; D042842:11-beta-Hydroxysteroid Dehydrogenases