title: Effects of tidal volume and PEEP on arterial blood gases and pulmonary mechanics during one-lung ventilation.
abstract: OBJECTIVE
  The main problem of one-lung ventilation (OLV) is hypoxemia. The use of a high tidal volume for preventing hypoxemia during OLV is controversial. We compared the effects of a high tidal volume versus a low tidal volume with or without PEEP on arterial oxygen tension (PaO(2)) and pulmonary mechanics during OLV.
  
  
  METHODS
  Sixty patients (age range, 16-65 years; ASA I, II) who underwent wedge resection with video-assisted thoracostomy during OLV were assigned to three groups: group I received a high tidal volume (10 ml/kg) (n = 20), group II received a low tidal volume (6 ml/kg) (n = 20), and group III received a low tidal volume (6 ml/kg) with PEEP (5 cmH(2)O) (n = 20). Patient hemodynamics, pulmonary mechanics, and arterial blood gases were measured before (T(0)) OLV and 5 (T(1)), 15 (T(2)), 30 (T(3)), and 45 min (T(4)) after OLV.
  
  
  RESULTS
  The PaO(2)/FiO(2) ratios of group II and III were significantly decreased and the incidence of hypoxemia was significantly higher in groups II and III than in group I (P < 0.05).
  
  
  CONCLUSIONS
  During OLV, mechanical ventilation with a low tidal volume with or without PEEP increased hypoxemia as compared to that when performing OLV with a high tidal volume.
authors.affiliation: Department of Anesthesiology and Pain Medicine, Chosun University Medical School, 588 Seasuk-dong, Donggu, Gwangju, 501 717, Korea.
authors.forename: Sang Hun
authors.initials: SH
authors.lastname: Kim
authors.forename: Ki Tae
authors.initials: KT
authors.lastname: Jung
authors.forename: Tae Hun
authors.initials: TH
authors.lastname: An
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D062186:Arterial Pressure / Q000502:physiology; D001784:Blood Gas Analysis / Q000379:methods*; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006439:Hemodynamics; D006801:Humans; D007431:Intraoperative Complications / Q000453:epidemiology / Q000628:therapy; D008168:Lung / Q000502:physiology* / Q000601:surgery; D008170:Lung Compliance / Q000502:physiology; D008297:Male; D008875:Middle Aged; D061810:One-Lung Ventilation / Q000379:methods*; D010100:Oxygen / Q000097:blood; D011175:Positive-Pressure Respiration / Q000379:methods*; D015656:Respiratory Mechanics / Q000502:physiology*; D013990:Tidal Volume / Q000502:physiology*; D055815:Young Adult
chemical_list: D010100:Oxygen