title: Respiratory monitoring by porphyrin modified quartz crystal microbalance sensors.
abstract: A respiratory monitoring system based on a quartz crystal microbalance (QCM) sensor with a functional film was designed and investigated. Porphyrins 5,10,15,20-tetrakis-(4-sulfophenyl)-21H,23H-porphine (TSPP) and 5,10,15,20-tetrakis-(4-sulfophenyl)-21H, 23H-porphine manganese (III) chloride (MnTSPP) used as sensitive elements were assembled with a poly(diallyldimethyl ammonium chloride) (PDDA). Films were deposited on the QCM resonators using layer-by-layer method in order to develop the sensor. The developed system, in which the sensor response reflects lung movements, was able to track human respiration providing respiratory rate (RR) and respiratory pattern (RP). The sensor system was tested on healthy volunteers to compare RPs and calculate RRs. The operation principle of the proposed system is based on the fast adsorption/desorption behavior of water originated from human breath into the sensor films deposited on the QCM electrode.
authors.affiliation: Graduate School of Environmental Engineering, The University of Kitakyushu, 1-1 Hibikino, Wakamatsu, Kitakyushu 808-0135, Japan. romanselyanchyn@gmail.com
authors.forename: Roman
authors.initials: R
authors.lastname: Selyanchyn
authors.forename: Serhiy
authors.initials: S
authors.lastname: Korposh
authors.forename: Shunichi
authors.initials: S
authors.lastname: Wakamatsu
authors.forename: Seung-Woo
authors.initials: SW
authors.lastname: Lee
mesh_terms: D015374:Biosensing Techniques; D004566:Electrodes; D006801:Humans; D008665:Metalloporphyrins / Q000737:chemistry*; D011095:Polyethylenes / Q000737:chemistry; D058525:Quartz Crystal Microbalance Techniques; D000644:Quaternary Ammonium Compounds / Q000737:chemistry; D056152:Respiratory Rate / Q000502:physiology*; D014867:Water / Q000378:metabolism
chemical_list: D008665:Metalloporphyrins; D011095:Polyethylenes; D000644:Quaternary Ammonium Compounds; D014867:Water; C041004:poly-N,N-dimethyl-N,N-diallylammonium chloride