title: Gold-coated silica-fiber hybrid materials for application in a novel hydrogen peroxide biosensor.
abstract: We describe the preparation and characterization of a novel type of core-shell hybrid material for application in a novel hydrogen peroxide biosensor, where the structure consists of a continuous gold shell that encapsulates the silica fiber. The SiO(2)@Au nanofibers had been synthesized by electrospinning silica sol, and then golden seeds were in situ grown on the fiber, lastly the gold-seeded silica fibers were further coated by continuous gold shells. The above nanocomposites had satisfactory chemical stability, excellent biocompatibility and efficient electron transfer property, which may have potential application for the highly sensitive chemical or biological sensors. Cyclic voltammetry (CV) was used to evaluate the electrochemical performance of the SiO(2)@Au nanocomposites at indium tin oxide (ITO). The biosensor showed high sensitivity and fast response upon the addition of H(2)O(2) and the linear range to H(2)O(2) was from 5×10(-6) to 1.0×10(-3)M with a detection limit of 2 μM (S/N=3). The apparent Michaelis-Menten constant of the biosensor was 1.11 mmol L(-1). These results indicated that SiO(2)@Au nanocomposites have potential for constructing of a variety of electrochemical biosensors.
authors.affiliation: Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai, China.
authors.forename: Jianhua
authors.initials: J
authors.lastname: Shen
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Yang
authors.forename: Yihua
authors.initials: Y
authors.lastname: Zhu
authors.forename: Haigang
authors.initials: H
authors.lastname: Kang
authors.forename: Huimin
authors.initials: H
authors.lastname: Cao
authors.forename: Chunzhong
authors.initials: C
authors.lastname: Li
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D055664:Electrochemical Techniques / Q000379:methods; D006046:Gold / Q000737:chemistry; D006861:Hydrogen Peroxide / Q000737:chemistry / Q000302:isolation & purification*; D057139:Nanofibers / Q000737:chemistry*; D012680:Sensitivity and Specificity; D012822:Silicon Dioxide / Q000737:chemistry
chemical_list: D006046:Gold; D012822:Silicon Dioxide; D006861:Hydrogen Peroxide