title: Paraganglioma of seminal vesicle and chromophobe renal cell carcinoma: a case report and literature review.
abstract: BACKGROUND
  Extra-adrenal paragangliomas are rare tumors that have been reported in many locations, including the kidney, urethra, urinary bladder, prostate, spermatic cord, gallbladder, uterus and vagina.
  
  
  METHODS
  This report describes, for the first time to the best of our knowledge, a primary paraganglioma of the seminal vesicle occurring in a 61-year-old male. The patient presented persistent arterial hypertension and a previous diagnosis of chromophobe renal cell carcinoma. It was hypothesized that the seminal vesicle tumor could be a metastasis from the chromophobe renal cell carcinoma. Immunohistochemical characterization revealed expression of synaptophysin and chromogranin in tumor cell nests and peripheral S100 protein expression in sustentacular cells. Succinate dehydrogenase A and B-related (SDHA and SDHB) expression was present in both tumors.
  
  
  CONCLUSIONS
  No genetic alterations to the VHL and SDHB genes were detected in either the tumor tissue or tissues adjacent to the tumor, which led us to rule out a hereditary syndrome that could explain the association between paraganglioma and chromophobe renal cell carcinoma in a patient with arterial hypertension.
authors.affiliation: Department of Pathology, Universidade Estadual de Campinas, Campinas, São Paulo, Brazil. cesalvarenga@gmail.com
authors.forename: César Augusto
authors.initials: CA
authors.lastname: Alvarenga
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Lopes
authors.forename: João
authors.initials: J
authors.lastname: Vinagre
authors.forename: Paula Itagyba
authors.initials: PI
authors.lastname: Paravidino
authors.forename: Marcelo
authors.initials: M
authors.lastname: Alvarenga
authors.forename: Adilson
authors.initials: A
authors.lastname: Prando
authors.forename: Lísias Nogueira
authors.initials: LN
authors.lastname: Castilho
authors.forename: Paula
authors.initials: P
authors.lastname: Soares
authors.forename: Athanase
authors.initials: A
authors.lastname: Billis
mesh_terms: D002292:Carcinoma, Renal Cell / Q000473:pathology*; D003937:Diagnosis, Differential; D005834:Genital Neoplasms, Male / Q000235:genetics / Q000473:pathology*; D006801:Humans; D006973:Hypertension / Q000209:etiology; D007680:Kidney Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000235:genetics / Q000473:pathology*; D010235:Paraganglioma / Q000235:genetics / Q000473:pathology*; D012669:Seminal Vesicles / Q000473:pathology*; D013385:Succinate Dehydrogenase / Q000235:genetics; D051794:Von Hippel-Lindau Tumor Suppressor Protein / Q000235:genetics
chemical_list: C108095:SDHB protein, human; D013385:Succinate Dehydrogenase; D051794:Von Hippel-Lindau Tumor Suppressor Protein; C497446:VHL protein, human