title: Apoptosis signaling in influenza virus propagation, innate host defense, and lung injury.
abstract: Programmed cell death is a crucial cellular response frequently observed in IV-infected tissue. This article reviews the current knowledge on the molecular virus-host interactions that induce apoptosis pathways in an IV-infected cell and the functional implications of these cellular signaling events on viral propagation at distinct steps during the viral replication cycle. Furthermore, it summarizes the role of IV-induced apoptosis pathways in equilibrating the host's antiviral immune response between effective viral clearance and development of severe apoptotic lung injury.
authors.affiliation: University of Giessen Lung Center, Department of Internal Medicine II, Giessen, Germany. susanne.herold@innere.med.uni-giessen.de
authors.forename: Susanne
authors.initials: S
authors.lastname: Herold
authors.forename: Stephan
authors.initials: S
authors.lastname: Ludwig
authors.forename: Stephan
authors.initials: S
authors.lastname: Pleschka
authors.forename: Thorsten
authors.initials: T
authors.lastname: Wolff
mesh_terms: D017209:Apoptosis; D006801:Humans; D007113:Immunity, Innate; D007251:Influenza, Human / Q000276:immunology* / Q000473:pathology* / Q000821:virology; D055370:Lung Injury; D009975:Orthomyxoviridae / Q000472:pathogenicity*; D014779:Virus Replication