title: Invasive Mycoleptodiscus fungal cellulitis and myositis.
abstract: We report progressive necrotizing fungal cellulitis and myositis in the leg of a patient with glioblastoma multiforme treated with temozolomide and corticosteroids. While the morphologic appearance of the isolate and its ability to grow at temperatures greater than 32°C were suggestive of Mycoleptodiscus indicus, some of the conidia were atypical for this species in that they had single septa and occasional lateral appendages. Furthermore, the isolate was different from M. indicus based on the sequencing analysis of two rDNA regions. This is the first case of Mycoleptodiscus invasive fungal disease in which the causative agent could not be resolved at the species level because of inconsistencies between morphological and molecular data.
authors.affiliation: Division of Infectious Diseases, Brigham & Women's Hospital, Boston, MA 02115, USA. skoo@partners.org
authors.forename: Sophia
authors.initials: S
authors.lastname: Koo
authors.forename: Deanna A
authors.initials: DA
authors.lastname: Sutton
authors.forename: Wendy W
authors.initials: WW
authors.lastname: Yeh
authors.forename: Elizabeth H
authors.initials: EH
authors.lastname: Thompson
authors.forename: Lynne
authors.initials: L
authors.lastname: Sigler
authors.forename: Judy F
authors.initials: JF
authors.lastname: Shearer
authors.forename: Deborah E
authors.initials: DE
authors.lastname: Hofstra
authors.forename: Brian L
authors.initials: BL
authors.lastname: Wickes
authors.forename: Francisco M
authors.initials: FM
authors.lastname: Marty
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage; D001203:Ascomycota / Q000302:isolation & purification*; D002481:Cellulitis / Q000150:complications / Q000175:diagnosis* / Q000382:microbiology* / Q000473:pathology; D016000:Cluster Analysis; D004271:DNA, Fungal / Q000737:chemistry / Q000235:genetics; D004275:DNA, Ribosomal / Q000737:chemistry / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000737:chemistry / Q000235:genetics; D003606:Dacarbazine / Q000008:administration & dosage / Q000031:analogs & derivatives; D005909:Glioblastoma / Q000150:complications / Q000188:drug therapy; D006801:Humans; D007866:Leg / Q000473:pathology; D008297:Male; D008969:Molecular Sequence Data; D009181:Mycoses / Q000150:complications / Q000175:diagnosis* / Q000382:microbiology* / Q000473:pathology; D009220:Myositis / Q000150:complications / Q000175:diagnosis* / Q000382:microbiology* / Q000473:pathology; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D000077204:Temozolomide
chemical_list: D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents; D018906:Antineoplastic Agents, Alkylating; D004271:DNA, Fungal; D004275:DNA, Ribosomal; D021903:DNA, Ribosomal Spacer; D003606:Dacarbazine; D000077204:Temozolomide