title: [The correlation between polymorphisms of genes with susceptibility to tuberculosis and the clinical characteristics of tuberculosis in 459 Han patients].
abstract: OBJECTIVE
  To study the correlation between polymorphisms of genes with susceptibility to tuberculosis and the clinical characteristics of tuberculosis in Han population.
  
  
  METHODS
  Four hundred and fifty-nine tuberculosis inpatients of Han population in Shanghai Pulmonary Hospital from Jan 2007 to Dec 2008 were recruited. The clinical characteristics of tuberculosis (gender, fever, extent of lesions, cavity formation, hemoptysis, initial treatment and retreatment) were observed. The polymorphisms of VDR gene (variants in FokI and TaqI), NRAMP1 gene (variants in INT4, D543N and 3 UTR), MBL gene (variants in HL, YX and QP) and IFNG gene (variants in 874AT) were genotyped by a variety of SNP genotyping techniques. The correlation between polymorphisms of genes with susceptibility to tuberculosis and the clinical characteristics of the disease was analyzed by ANOVAs.
  
  
  RESULTS
  The frequency of CC, CT and TT variants of FokI in VDR gene in cases with fever were 54.7% (29/53), 13.2% (7/53) and 32.1% (17/53), respectively, compared to 40.6% (52/128), 30.5% (39/128) and 28.9% (37/128) in cases without fever, the difference being significant (χ² = 6.183, P < 0.05). In patients with CT variants, 15.2% (7/46) had fever, while in patients with non-CT variants, 34.1% (46/135) had fever (χ² = 5.891, P < 0.05), suggesting that patients with CT variants were less likely to have fever. The frequencies of TT + TC and CC variants of QP in the MBL gene in initial treatment cases were 28.3% (60/212) and 71.7% (152/212), respectively, compared to 19.1% (41/215) and 80.9% (174/215) in retreatment cases, the difference being significant (χ² = 5.038, P < 0.05). No significant correlation was observed between the other variants and the clinical characteristics of tuberculosis (χ² = 0.001 - 2.732, P > 0.05).
  
  
  CONCLUSIONS
  The polymorphisms of FokI in VDR gene was associated with fever among the clinical characteristics of tuberculosis, and patients with CT variants might be protected from fever. The polymorphisms of QP in MBL gene might be associated with recurrence of tuberculosis.
authors.affiliation: Shanghai Key Laboratory of Tuberculosis, Tuberculosis Diagnosis Center, Shanghai Pulmonary Hospital Affiliated to Tongji University, Shanghai 200433, China.
authors.forename: Zhi-bin
authors.initials: ZB
authors.lastname: Liu
authors.forename: Rui-juan
authors.initials: RJ
authors.lastname: Zheng
authors.forename: He-ping
authors.initials: HP
authors.lastname: Xiao
authors.forename: Wei
authors.initials: W
authors.lastname: Sha
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhang
authors.forename: Fu-rong
authors.initials: FR
authors.lastname: Wu
authors.forename: Hua
authors.initials: H
authors.lastname: Sun
authors.forename: Zhong-shun
authors.initials: ZS
authors.lastname: Zhang
authors.forename: Hai-yan
authors.initials: HY
authors.lastname: Cui
authors.forename: Yi-dian
authors.initials: YD
authors.lastname: Liu
authors.forename: Shen-jie
authors.initials: SJ
authors.lastname: Tang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics; D002681:China; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D018167:Receptors, Calcitriol / Q000235:genetics; D014376:Tuberculosis / Q000235:genetics*; D055815:Young Adult
chemical_list: D018167:Receptors, Calcitriol