title: [Analysis of high risk factors for relapse of leukemia after allogeneic hematopoietic stem cell transplantation].
abstract: OBJECTIVE
  To screen the high risk factors for relapse after allogeneic hematopoietic stem cell transplantation (allo-HSCT) in acute lymphocytic leukemia (ALL), acute myeloid leukemia (AML) and chronic myeloid leukemia (CML) respectively, then to compare the contribution of each risk factor to relapse and investigate the relevant mechanisms.
  
  
  METHODS
  A retrospective study from single center involved in 262 evaluable cases of leukemia received allo-HSCT over the past 8 years, of them 69 cases with ALL, 90 AML (except APL) and 103 CML. Cox proportional hazard regression model was used for univariate and multivariate analysis to screen the high risk factors.
  
  
  RESULTS
  The risk factors significantly affecting relapse in ALL included: Cytogenetic risk classification, the cycles of initial induction chemotherapy; AML: Cytogenetic risk classification, minimal residual disease (MRD) level before transplant, reconstitution of WBC, and CD4(+)/CD8(+) lymphocyte ratio in the graft; CML: disease stage before transplant.
  
  
  CONCLUSIONS
  The relapse risk after HSCT of ALL mainly depends on the grade of malignancies, and the relapse risk of AML is closely related to the course of transplant. Chronic phase of CML favors a good prognosis after HSCT. Cytogenetic risk classification is the most relevant predictor of relapse after HSCT.
authors.affiliation: Jiangsu Insititute of Hematology, The First Affiliiliated Hospital of Soochow University, Suzhou, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Chen
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
authors.forename: Aining
authors.initials: A
authors.lastname: Sun
authors.forename: Hui-ying
authors.initials: HY
authors.lastname: Qiu
authors.forename: Yue
authors.initials: Y
authors.lastname: Han
authors.forename: Xiao-wen
authors.initials: XW
authors.lastname: Tang
authors.forename: Zheng-zheng
authors.initials: ZZ
authors.lastname: Fu
authors.forename: Miao
authors.initials: M
authors.lastname: Miao
authors.forename: Guang-sheng
authors.initials: GS
authors.lastname: He
authors.forename: Zheng-ming
authors.initials: ZM
authors.lastname: Jin
authors.forename: De-pei
authors.initials: DP
authors.lastname: Wu
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007938:Leukemia / Q000473:pathology* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D014184:Transplantation, Homologous; D055815:Young Adult