title: Surgical resection for non-familial adenomatous polyposis-related intra-abdominal fibromatosis.
abstract: BACKGROUND
  Intra-abdominal fibromatosis (IAF) in the context of familial adenomatosis polyposis (FAP) is associated with significant morbidity and high recurrence rates after surgical resection. Non-surgical treatments are therefore advocated. This study explored outcomes in patients with IAF not associated with FAP who underwent surgical resection.
  
  
  METHODS
  Data were analysed from a prospectively collected database at a sarcoma tertiary referral centre.
  
  
  RESULTS
  From 2001 to 2011, 15 patients without FAP underwent primary curative surgical resection of IAF. Their median (range) age was 42 (19-64) years. Median tumour size was 18 (8.5-25) cm and weight 1306 (236-2228) g. Complete macroscopic clearance was obtained in all patients. There were no deaths in hospital or within 30 days and only one patient developed a major complication. Median follow-up was 40 (6-119) months. During follow-up two patients developed a recurrence after a disease-free interval of 12 and 16 months.
  
  
  CONCLUSIONS
  In contrast to FAP-associated IAF, non-FAP-associated IAF has a very low recurrence rate after surgical resection. Surgical resection is therefore advocated as first-line treatment in patients with non-FAP-associated IAF when resection can be performed with low morbidity.
authors.affiliation: Sarcoma and Melanoma Unit, Department of Academic Surgery, Royal Marsden Hospital NHS Foundation Trust, Fulham Road, London SW3 6JJ, UK. michelle.wilkinson@icr.ac.uk
authors.forename: M J
authors.initials: MJ
authors.lastname: Wilkinson
authors.forename: J E F
authors.initials: JE
authors.lastname: Fitzgerald
authors.forename: J M
authors.initials: JM
authors.lastname: Thomas
authors.forename: A J
authors.initials: AJ
authors.lastname: Hayes
authors.forename: D C
authors.initials: DC
authors.lastname: Strauss
mesh_terms: D018256:Adenomatous Polyps / Q000150:complications*; D000328:Adult; D016063:Blood Loss, Surgical; D005260:Female; D018221:Fibromatosis, Abdominal / Q000000981:diagnostic imaging / Q000601:surgery*; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000209:etiology; D011300:Preoperative Care; D011446:Prospective Studies; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014781:Viscera / Q000601:surgery; D055815:Young Adult