title: Association of coronary plaque composition and arterial remodelling: a optical coherence tomography study.
abstract: BACKGROUND
  Conflicting data have been reported about the association between plaque composition and remodelling index (RI). The aim of this study is to evaluate the relationship between plaque morphology obtained by optical coherence tomography (OCT) and arterial remodelling.
  
  
  RESULTS
  OCT and intravascular ultrasound imaging pull back was performed at corresponding sites on 94 lesions in 47 patients. OCT plaque characteristics for lipid content, fibrous cap thickness, thin-cap fibroatheroma (TCFA), plaque rupture, thrombus, calcification and erosion were derived using validated criteria. Compared with intermediate/negative remodelling (RI<1.0), positive remodelling (RI>1.0) was associated with presence of higher lipid pool (2.86 ± 0.42 vs. 2.20 ± 0.78; p<0.001), thin fibrous cap (47.86 ± 25.43 μm vs. 74.41 ± 32.41 μm; p<0.001), TCFA>3mm (82.1% vs. 22.7%; p<0.0001), plaque rupture and thrombus (42.8% vs. 19.7%; p = 0.024), and higher plaque burden (73.70 vs. 70.70; p = 0.048). No difference was observed in the presence of calcification and plaque erosions.
  
  
  CONCLUSIONS
  Coronary lesions with positive remodelling show higher incidences of vulnerable plaque and plaque rupture across the lesion length. This potentially explains the correlation between unstable coronary syndromes and positive remodelling.
authors.affiliation: Department of Cardiology, St George's Hospital, Blackshaw Road, Tooting, London, UK. sudhirrathore@hotmail.com
authors.forename: Sudhir
authors.initials: S
authors.lastname: Rathore
authors.forename: Mitsuyasu
authors.initials: M
authors.lastname: Terashima
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Matsuo
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Kinoshita
authors.forename: Masashi
authors.initials: M
authors.lastname: Kimura
authors.forename: Etsuo
authors.initials: E
authors.lastname: Tsuchikane
authors.forename: Kenya
authors.initials: K
authors.lastname: Nasu
authors.forename: Mariko
authors.initials: M
authors.lastname: Ehara
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Asakura
authors.forename: Osamu
authors.initials: O
authors.lastname: Katoh
authors.forename: Takahiko
authors.initials: T
authors.lastname: Suzuki
mesh_terms: D000368:Aged; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D003328:Coronary Thrombosis / Q000473:pathology; D003331:Coronary Vessels / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D005355:Fibrosis; D006801:Humans; D007564:Japan; D008055:Lipids / Q000032:analysis; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D058226:Plaque, Atherosclerotic / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology*; D012422:Rupture, Spontaneous; D041623:Tomography, Optical Coherence; D018084:Ultrasonography, Interventional; D061205:Vascular Calcification / Q000473:pathology
chemical_list: D008055:Lipids