title: [(Cp-R)M(CO)3] (M=Re or 99mTc) Arylsulfonamide, arylsulfamide, and arylsulfamate conjugates for selective targeting of human carbonic anhydrase IX.
abstract: Enhanced receptor selectivity: carbonic anhydrase inhibitors are relevant for both cancer diagnosis and therapy. Combining non-radioactive Re compounds with their radioactive (99m)Tc homologs enables the use of identical molecules for therapy and imaging (theragnostic). The syntheses and in vitro evaluation of [(Cp-R)M(CO)(3)] (Cp=cyclopentadienyl, M=Re, (99m)Tc) with R being a highly potent carbonic-anhydrase-targeting vector is reported.
authors.affiliation: Institute of Inorganic Chemistry, University of Zurich, Switzerland.
authors.forename: Daniel
authors.initials: D
authors.lastname: Can
authors.forename: Bernhard
authors.initials: B
authors.lastname: Spingler
authors.forename: Paul
authors.initials: P
authors.lastname: Schmutz
authors.forename: Filipa
authors.initials: F
authors.lastname: Mendes
authors.forename: Paula
authors.initials: P
authors.lastname: Raposinho
authors.forename: Célia
authors.initials: C
authors.lastname: Fernandes
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Carta
authors.forename: Alessio
authors.initials: A
authors.lastname: Innocenti
authors.forename: Isabel
authors.initials: I
authors.lastname: Santos
authors.forename: Claudiu T
authors.initials: CT
authors.lastname: Supuran
authors.forename: Roger
authors.initials: R
authors.lastname: Alberto
mesh_terms: D000951:Antigens, Neoplasm / Q000737:chemistry* / Q000378:metabolism; D000071231:Carbonic Anhydrase IX; D002257:Carbonic Anhydrase Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D002256:Carbonic Anhydrases / Q000737:chemistry* / Q000378:metabolism; D049109:Cell Proliferation / Q000187:drug effects; D056831:Coordination Complexes / Q000737:chemistry / Q000494:pharmacology; D057809:HEK293 Cells; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D015609:Organotechnetium Compounds / Q000737:chemistry; D012211:Rhenium / Q000737:chemistry; D013449:Sulfonamides / Q000737:chemistry*; D013451:Sulfonic Acids / Q000737:chemistry*; D013629:Tamoxifen / Q000737:chemistry
chemical_list: D000951:Antigens, Neoplasm; D002257:Carbonic Anhydrase Inhibitors; D056831:Coordination Complexes; D015609:Organotechnetium Compounds; D013449:Sulfonamides; D013451:Sulfonic Acids; D013629:Tamoxifen; D012211:Rhenium; C005741:sulfamic acid; C089226:CA9 protein, human; D000071231:Carbonic Anhydrase IX; D002256:Carbonic Anhydrases