title: Neutrophils under tension.
abstract: An article by Houk et al. (2012) in Cell provides insight into the mechanisms confining membrane protrusions to the front of migrating neutrophils. The authors rule out a role for diffusion of inhibitory signals and show that membrane tension is necessary and sufficient to restrict signals that lead to protrusions.
authors.affiliation: Laboratory of Cellular and Molecular Biology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Philippe V
authors.initials: PV
authors.lastname: Afonso
authors.forename: Carole A
authors.initials: CA
authors.lastname: Parent