title: [A case of advanced gastric cancer with liver metastases successively treated with S-1/CDDP combination therapy followed by curative resection].
abstract: The patient was a 67-year-old male with type-3 gastric cancer from the upper body of the stomach to the cardia. An abdominal computed tomography scan revealed liver metastases(S8)(T2N0M0H1, Stage IV). The patient received neoadjuvant combined chemotherapy with S-1 and CDDP. S-1(120mg/body/day)was orally administered for 3 weeks followed by 2 drug-free weeks as a course, and CDDP(60mg/m2)was administered by intravenous infusion on day 8. After the second course, significant tumor reduction and disappearance of liver metastases resulted. Total gastrectomy, splenectomy, cholecystectomy, and D2 nodal dissection were performed. The histological diagnosis revealed no metastases in all lymph nodes: Stage I B. The combined neoadjuvant chemotherapy with S-1 and CDDP can be considered an effective treatment for advanced gastric cancer.
authors.affiliation: Dept. of Surgery, Misawa City Hospital, Japan.
authors.forename: Yoshiya
authors.initials: Y
authors.lastname: Ishizawa
authors.forename: Shunji
authors.initials: S
authors.lastname: Aizawa
authors.forename: Dai
authors.initials: D
authors.lastname: Okudera
authors.forename: Makoto
authors.initials: M
authors.lastname: Yokoyama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Aizawa
authors.forename: Yuki
authors.initials: Y
authors.lastname: Satoh
authors.forename: Masaharu
authors.initials: M
authors.lastname: Kasai
authors.forename: Masaki
authors.initials: M
authors.lastname: Munakata
authors.forename: Yu
authors.initials: Y
authors.lastname: Sakata
authors.forename: Kenichi
authors.initials: K
authors.lastname: Hakamada
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001706:Biopsy; D002945:Cisplatin / Q000008:administration & dosage; D004338:Drug Combinations; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D010094:Oxonic Acid / Q000008:administration & dosage; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005641:Tegafur / Q000008:administration & dosage; D014057:Tomography, X-Ray Computed
chemical_list: D004338:Drug Combinations; C079198:S 1 (combination); D005641:Tegafur; D010094:Oxonic Acid; D002945:Cisplatin