title: Sesame oil consumption exerts a beneficial effect on endothelial function in hypertensive men.
abstract: BACKGROUND
  The aim of the study was to investigate the effects of sesame oil on endothelial function and to detect the underlying mechanisms, both in the postprandial state and after long-term consumption.
  
  
  METHODS
  We enrolled 30 hypertensive men in a two-phase study. In the first phase, 26 volunteers consumed 35 g of either sesame oil or control oil. Endothelial function, inflammatory activation and nitric oxide syntase (NOS) inhibition was assessed after a 12-hour fast and 2 hours after consumption of an oil-containing standardized meal. In the second phase, 30 volunteers consumed 35 g of sesame oil or control oil daily for 2 months and the above-mentioned parameters were assessed at baseline, 15, 30 and 60 days.
  
  
  METHODS
  Endothelial function was estimated by endothelium-dependent FMD (flow-mediated dilatation) of the brachial artery.
  
  
  RESULTS
  Flow-mediated dilatation (FMD) improved significantly both after acute (p = 0.001) and long-term sesame oil consumption (p = 0.015, p = 0.005 and p = 0.011 for 15, 30 and 60 days respectively). Intracellular adhesion molecule (ICAM) levels decreased significantly after only 60 days of daily sesame oil intake (p = 0.014). By contrast, no changes were observed in the control group in either phase of the study.
  
  
  CONCLUSIONS
  This is the first study to show that sesame oil consumption exerts a beneficial effect on endothelial function and this effect is sustained with long-term daily use.
authors.affiliation: Laboratory of Nutrition and Clinical Dietetics, Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
authors.forename: Kalliopi
authors.initials: K
authors.lastname: Karatzi
authors.forename: Kimon
authors.initials: K
authors.lastname: Stamatelopoulos
authors.forename: Maritta
authors.initials: M
authors.lastname: Lykka
authors.forename: Pigi
authors.initials: P
authors.lastname: Mantzouratou
authors.forename: Sofia
authors.initials: S
authors.lastname: Skalidi
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Zakopoulos
authors.forename: Christos
authors.initials: C
authors.lastname: Papamichael
authors.forename: Labros S
authors.initials: LS
authors.lastname: Sidossis
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001120:Arginine / Q000031:analogs & derivatives / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D001916:Brachial Artery / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology*; D004032:Diet; D004730:Endothelium, Vascular / Q000378:metabolism / Q000503:physiopathology*; D006115:Greece; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000175:diagnosis / Q000178:diet therapy* / Q000503:physiopathology; D018836:Inflammation Mediators / Q000097:blood; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period; D012715:Sesame Oil / Q000008:administration & dosage*; D013997:Time Factors; D016896:Treatment Outcome; D014463:Ultrasonography; D014664:Vasodilation
chemical_list: D015415:Biomarkers; C573420:ICAM1 protein, human; D018836:Inflammation Mediators; D018799:Intercellular Adhesion Molecule-1; C018524:N,N-dimethylarginine; D012715:Sesame Oil; D001120:Arginine