title: pH- and redox-responsive polysaccharide-based microcapsules with autofluorescence for biomedical applications.
abstract: Autofluorescent microcapsules were assembled by covalent cross-linking of polysaccharide alginate dialdehyde (ADA) derivative and cystamine dihydrochloride (CM) through a layer-by-layer (LBL) technique. The formulated Schiff base and disulfide bonds render capsules with pH- and redox-responsive properties for pinpointed intracellular delivery based on the physiological difference between intracellular and extracellular environments. This simple and versatile method could be extended to other polysaccharide derivatives for the fabrication of autofluorescent nano- and micromaterials with dual stimuli response for biomedical applications.
authors.affiliation: Beijing National Laboratory for Molecular Sciences, Center for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Zhong Guan Cun, Beijing, 100190, PR China.
authors.forename: Liang
authors.initials: L
authors.lastname: Gao
authors.forename: Jinbo
authors.initials: J
authors.lastname: Fei
authors.forename: Jie
authors.initials: J
authors.lastname: Zhao
authors.forename: Wei
authors.initials: W
authors.lastname: Cui
authors.forename: Yue
authors.initials: Y
authors.lastname: Cui
authors.forename: Junbai
authors.initials: J
authors.lastname: Li
mesh_terms: D000464:Alginates / Q000737:chemistry; D002214:Capsules / Q000737:chemistry*; D003538:Cystamine / Q000737:chemistry; D016503:Drug Delivery Systems; D005453:Fluorescence; D006801:Humans; D006863:Hydrogen-Ion Concentration; D015394:Molecular Structure; D010084:Oxidation-Reduction; D011134:Polysaccharides / Q000737:chemistry*
chemical_list: D000464:Alginates; D002214:Capsules; D011134:Polysaccharides; D003538:Cystamine