title: The IL-8 gene polymorphisms and the risk of the hepatitis B virus/infected patients.
abstract: Interleukin-8 (IL-8) belongs to the superfamily of CXC chemokines, contributing to human cancer progression through potential mitogenic, angiogenic, and motogenic functions. We hypothesize that the functional polymorphism of IL-8 may influence the inflammatory process during pathological stage from hepatitis to hepatocellular carcinoma (HCC). Two polymorphisms in the IL-8 gene (-251A/T and +781C/T) were examined in 160 cases of chronic hepatitis B, 80 cases of hepatitis B virus (HBV)-related liver cirrhosis (LC), 150 cases of HBV-related HCC, and 150 healthy controls using polymerase chain reaction-restriction fragment length polymorphism method and DNA sequencing. In the LC group, the AA genotypes were associated with a significantly decreased risk of LC compared with the TT genotype (OR=0.14, 95% CI 0.02-0.87, p=0.035). The data also revealed that subjects with the A allele appeared to have lower susceptibility to LC than those with the T allele (OR=0.48, 95% CI 0.25-0.92, p=0.027). The +781C/T polymorphism of IL-8 was not found relevant to the liver diseases. This study indicated that the IL-8 gene -251 AA genotype might be a protect factor for LC.
authors.affiliation: Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Qin
authors.forename: Yan
authors.initials: Y
authors.lastname: Deng
authors.forename: Xiang-Cheng
authors.initials: XC
authors.lastname: Liao
authors.forename: Cui-Ju
authors.initials: CJ
authors.lastname: Mo
authors.forename: Xi
authors.initials: X
authors.lastname: Li
authors.forename: Hui-Ling
authors.initials: HL
authors.lastname: Wu
authors.forename: Ya-Ni
authors.initials: YN
authors.lastname: He
authors.forename: Xia-Mei
authors.initials: XM
authors.lastname: Huang
authors.forename: Tao
authors.initials: T
authors.lastname: Peng
authors.forename: Zhi-Ping
authors.initials: ZP
authors.lastname: Chen
authors.forename: Shan
authors.initials: S
authors.lastname: Li
mesh_terms: D000328:Adult; D001483:Base Sequence; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics; D006515:Hepatitis B virus / Q000472:pathogenicity*; D006761:Hospitals; D006801:Humans; D016209:Interleukin-8 / Q000235:genetics*; D008107:Liver Diseases / Q000235:genetics* / Q000821:virology*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide
chemical_list: D016209:Interleukin-8