title: Protein localization with flexible DNA or RNA.
abstract: Localization of activity is ubiquitous in life, and also within sub-cellular compartments. Localization provides potential advantages as different proteins involved in the same cellular process may supplement each other on a fast timescale. It might also prevent proteins from being active in other regions of the cell. However localization is at odds with the spreading of unbound molecules by diffusion. We model the cost and gain for specific enzyme activity using localization strategies based on binding to sites of intermediate specificity. While such bindings in themselves decrease the activity of the protein on its target site, they may increase protein activity if stochastic motion allows the acting protein to touch both the intermediate binding site and the specific site simultaneously. We discuss this strategy in view of recent suggestions on long non-coding RNA as a facilitator of localized activity of chromatin modifiers.
authors.affiliation: Niels Bohr institute, University of Copenhagen, Copenhagen, Denmark. sebbeb@nbi.dk
authors.forename: Sebastian
authors.initials: S
authors.lastname: Bernhardsson
authors.forename: Namiko
authors.initials: N
authors.lastname: Mitarai
authors.forename: Kim
authors.initials: K
authors.lastname: Sneppen
mesh_terms: D001665:Binding Sites; D042002:Chromatin Assembly and Disassembly; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism*; D011485:Protein Binding; D012313:RNA / Q000737:chemistry* / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins; D016601:RNA-Binding Proteins; D012313:RNA; D004247:DNA