title: [State of antioxidant system in patients with multiple sclerosis during therapy].
abstract: Activity of erytrocyte glutationperoxidase (GP), glutationreductase (GR), glutationtransferase (GT), glucose-6-phosphatdehydrogenase (G6PDH), catalase and superoxiddysmutase (SOD), and also, the level of malonic dialdehyde (MDA) and total antioxidant activity of blood serum were studied in patients with different types of multiple sclerosis. Investigation of peripherical blood was carried out on first day of treatment and after standard therapy of copaxone. All MS patients had high level of MDA and activity of GP in erythrocytes in comparison with a control group. Other antioxidant enzymes of erythrocytes and total antioxidant activity of blood serum exhibited weak positive dynamics in patients with a relapsing remittance of multiple sclerosis (RRMS). Decrease of activity of antioxidant system in patients with secondary progression multiple sclerosis (SPMS) was more pronounced and remained unchanged after the treatment. This is consistent with the more severe clinical course of thise disease.
authors.forename: L P
authors.initials: LP
authors.lastname: Smirnova
authors.forename: N V
authors.initials: NV
authors.lastname: Krotenko
authors.forename: E V
authors.initials: EV
authors.lastname: Grishko
authors.forename: N M
authors.initials: NM
authors.lastname: Krotenko
authors.forename: V M
authors.initials: VM
authors.lastname: Alifirova
authors.forename: S A
authors.initials: SA
authors.lastname: Ivanova
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000627:therapeutic use*; D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D016022:Case-Control Studies; D004912:Erythrocytes / Q000201:enzymology / Q000378:metabolism; D000068717:Glatiramer Acetate; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008315:Malondialdehyde / Q000097:blood; D009103:Multiple Sclerosis / Q000097:blood / Q000188:drug therapy* / Q000201:enzymology* / Q000276:immunology; D018384:Oxidative Stress / Q000187:drug effects; D010455:Peptides / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D000276:Adjuvants, Immunologic; D000975:Antioxidants; D010455:Peptides; D008315:Malondialdehyde; D000068717:Glatiramer Acetate