title: Cardiopulmonary bypass model in the rat: a new minimal invasive model with a low flow volume.
abstract: Numerous cardiopulmonary bypass (CPB) models in the rat have already been described, but these models often have an important mortality and differ a lot from human clinical conditions thus making them hardly usable. The CPB model in the rat we describe allows a femoro-femoral support CPB with a low priming volume, minimal surgical approach and excellent peroperative survival. This CPB model in the rat allows evaluating extracorporeal circulation effects.
authors.affiliation: Department of Thoracic and CardioVascular Surgery, University Hospital, CHU Pierre Zobda Quitmann, Martinique, France. guillaumelebreton@live.fr
authors.forename: Guillaume
authors.initials: G
authors.lastname: Lebreton
authors.forename: Fabienne
authors.initials: F
authors.lastname: Tamion
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Bessou
authors.forename: Fabien
authors.initials: F
authors.lastname: Doguet
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D001810:Blood Volume; D002315:Cardiopulmonary Bypass / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D004867:Equipment Design; D005263:Femoral Artery; D005268:Femoral Vein; D006339:Heart Rate; D008297:Male; D023421:Models, Animal; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D015415:Biomarkers; D014409:Tumor Necrosis Factor-alpha