title: [Surveillance of resistance to antitubercular drugs in Cuba, 2000-2009].
abstract: OBJECTIVE
  Determine the prevalence of resistance to antitubercular drugs in Cuba in the 2000-2009 decade.
  
  
  METHODS
  A prospective longitudinal study was conducted. The sample group consisted of 2,285 Mycobacterium tuberculosis isolates obtained from throughout the country in the period from 1 January 2000 to 31 December 2009. The proportion method was used in Löwenstein-Jensen media with the first-line drugs: isoniazid, streptomycin, ethambutol, and rifampicin.
  
  
  RESULTS
  In the new cases and patients with a history of previous treatment, resistance was 8.5% and 37.0%, respectively. In these case categories, multidrug resistance was 0.4% and 8.8%, respectively.
  
  
  CONCLUSIONS
  This study shows low prevalence of multidrug-resistant strains in Cuba. The results reflect the progress made by the national control program, which is currently working on the elimination of tuberculosis as a public health problem in the country.
authors.affiliation: Laboratorio Nacional de Referencia e Investigaciones en Tuberculosis y Micobacterias, Centro Colaborador de la OPS/OMS, Instituto de Medicina Tropical Pedro Kourí, La Habana, Cuba. emontoro@ipk.sld.cu
authors.forename: Ernesto
authors.initials: E
authors.lastname: Montoro
authors.forename: Dihadenys
authors.initials: D
authors.lastname: Lemus
authors.forename: Miguel
authors.initials: M
authors.lastname: Echemendia
authors.forename: Raúl
authors.initials: R
authors.lastname: Diaz
authors.forename: Lilian
authors.initials: L
authors.lastname: Mederos
authors.forename: Maria Rosarys
authors.initials: MR
authors.lastname: Martinez
authors.forename: Alina
authors.initials: A
authors.lastname: Llop
authors.forename: Maria Josefa
authors.initials: MJ
authors.lastname: Llanes
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology* / Q000627:therapeutic use; D003462:Cuba / Q000453:epidemiology; D004352:Drug Resistance, Microbial; D024901:Drug Resistance, Multiple, Bacterial; D005500:Follow-Up Studies; D006801:Humans; D017053:Infection Control / Q000458:organization & administration; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000302:isolation & purification; D011159:Population Surveillance; D015995:Prevalence; D014376:Tuberculosis / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology* / Q000517:prevention & control; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology / Q000517:prevention & control
chemical_list: D000995:Antitubercular Agents