title: Comparison between three-dimensional speckle-tracking echocardiography and cardiac magnetic resonance imaging for quantification of left ventricular volumes and function.
abstract: OBJECTIVE
  We evaluated the accuracy of three-dimensional speckle-tracking echocardiography (3DSTE) to evaluate left ventricular (LV) volumes, ejection fraction (EF), and global circumferential strain (CS) in comparison with cardiac magnetic resonance imaging (MRI) in a healthy population.
  
  
  RESULTS
  A total of 45 out of 50 consecutive healthy subjects (38 males, age 45 ± 15 years) successfully underwent both 3DSTE and MRI on the same day. Three-dimensional echocardiography data sets were analysed using speckle tracking to measure LV end-diastolic and end-systolic volumes, EF, and global CS. With MRI, the method of discs approximation was used to obtain volumes and the EF, whereas CS was acquired using myocardial tissue tagging. Inter-technique comparisons included regression and the Bland-Altman analysis. For quantification of LV volumes, 3DSTE correlated well with MRI (r: 0.75-0.81), but volumes were significantly underestimated with relatively large biases (13-34 mL) and wide limits of agreement (SD: 11-25 mL). However, excellent accuracy was revealed for measurement of EF by 3DSTE with a good correlation (r: 0.91), minimal bias, and narrow limits of agreement (0.6 ± 1.7%) compared with MRI. For measurement of CS, a large mean bias was found between techniques (10.0%), despite narrow limits of agreement (SD: 1.7%) and a good correlation between techniques (r: 0.80).
  
  
  CONCLUSIONS
  Although 3DSTE-derived LV volumes are underestimated in most patients compared with MRI, measurement of the LVEF revealed excellent accuracy. Measurements of CS were systematically greater (i.e. more negative) with 3DSTE than MRI, which likely reflects various inter-technique differences that preclude direct comparability of their measurements.
authors.affiliation: Department of Cardiology 5F 003, Institute for Cardiovascular Research (ICaR-VU), VU University Medical Center, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands. s.kleijn@vumc.nl
authors.forename: Sebastiaan A
authors.initials: SA
authors.lastname: Kleijn
authors.forename: Wessel P
authors.initials: WP
authors.lastname: Brouwer
authors.forename: Mohamed F A
authors.initials: MF
authors.lastname: Aly
authors.forename: Iris K
authors.initials: IK
authors.lastname: Rüssel
authors.forename: Gerben J
authors.initials: GJ
authors.lastname: de Roest
authors.forename: Aernout M
authors.initials: AM
authors.lastname: Beek
authors.forename: Albert C
authors.initials: AC
authors.lastname: van Rossum
authors.forename: Otto
authors.initials: O
authors.lastname: Kamp
mesh_terms: D019560:Echocardiography, Three-Dimensional; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D016014:Linear Models; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008875:Middle Aged; D013223:Statistics as Topic; D016277:Ventricular Function, Left