title: Successful use of interleukin 6 antagonist tocilizumab in a patient with refractory cutaneous lupus and urticarial vasculitis.
abstract: Tocilizumab (Actemra; Genentech, Inc) is the first biologic therapy targeting the cytokine interleukin 6 (IL-6). It is a humanized monoclonal immunoglobulin G1 antibody against the α-chain of the IL-6 receptor that prevents the binding of IL-6 to membrane-bound and -soluble IL-6 receptor. It was approved by the US Food and Drug Administration in January 2010 for rheumatoid arthritis refractory to other approved therapies and in April 2011 for systemic juvenile idiopathic arthritis. It has been used as an off-label treatment in many autoimmune diseases, where IL-6 plays a major role in pathogenesis. We report a case of refractory systemic lupus erythematosus in a 22-year-old woman with recurrent high-grade fever, polyarthritis, diffuse rash with urticarial vasculitis, and tumid lupus who did not respond to topical corticosteroids, photoprotection, antimalarials, methotrexate, anakinra, mycophenolate mofetil, etanercept, and intravenous immunoglobulin therapy. Symptoms recurred after corticosteroid tapers below 10 mg. She was noted to have an elevated IL-6 level, and tocilizumab was started. She responded favorably with remission of fever, arthritis, and skin manifestations and was able to taper corticosteroid therapy successfully.
authors.affiliation: Division of Rheumatology, Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. makol.ashima@mayo.edu.
authors.forename: Ashima
authors.initials: A
authors.lastname: Makol
authors.forename: Lawrence E
authors.initials: LE
authors.lastname: Gibson
authors.forename: Clement J
authors.initials: CJ
authors.lastname: Michet
mesh_terms: D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage*; D001706:Biopsy; D004351:Drug Resistance; D005076:Exanthema / Q000209:etiology / Q000473:pathology*; D005260:Female; D006801:Humans; D056747:Immunomodulation; D015850:Interleukin-6 / Q000378:metabolism*; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000150:complications / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D058990:Molecular Targeted Therapy / Q000379:methods; D012008:Recurrence; D012074:Remission Induction / Q000379:methods; D016896:Treatment Outcome; D014657:Vasculitis / Q000209:etiology / Q000473:pathology*; D055815:Young Adult
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D015850:Interleukin-6; C502936:tocilizumab