title: Inflammation-induced immune suppression of the fetus: a potential link between chorioamnionitis and postnatal early onset sepsis.
abstract: Chorioamnionitis which results from microbial invasion of the amniotic cavity is the most frequent cause of preterm birth. Chorioamnionitis is associated with an increased risk of early-onset sepsis but the mechanisms underlying this association remain largely unknown. We hypothesize that developmental alterations of fetal organs and the immune system in the course of chorioamnionitis determine the risk of development of early onset sepsis. The purpose of this review is therefore to summarize the consequences of chorioamnionitis on fetal development and speculate how those antenatal changes might predispose to early onset sepsis.
authors.affiliation: Maastricht University Medical Center, Department of Pediatrics, School of Oncology and Developmental Biology, Maastricht, The Netherlands.
authors.forename: Tim G A M
authors.initials: TG
authors.lastname: Wolfs
authors.forename: Reint K
authors.initials: RK
authors.lastname: Jellema
authors.forename: Giovanni
authors.initials: G
authors.lastname: Turrisi
authors.forename: Elisa
authors.initials: E
authors.lastname: Becucci
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Buonocore
authors.forename: Boris W
authors.initials: BW
authors.lastname: Kramer
mesh_terms: D000818:Animals; D002821:Chorioamnionitis / Q000276:immunology*; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000276:immunology*; D007422:Intestines / Q000276:immunology; D008168:Lung / Q000276:immunology; D011247:Pregnancy; D047928:Premature Birth / Q000276:immunology*; D020545:Respiratory Mucosa / Q000276:immunology; D018805:Sepsis / Q000276:immunology*; D013154:Spleen / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology