title: Potent norovirus inhibitors based on the acyclic sulfamide scaffold.
abstract: The development of small molecule therapeutics to combat norovirus infection is of considerable interest from a public health perspective because of the highly contagious nature of noroviruses. A series of amino acid-derived acyclic sulfamide-based norovirus inhibitors has been synthesized and evaluated using a cell-based replicon system. Several compounds were found to display potent anti-norovirus activity, low toxicity, and good aqueous solubility. These compounds are suitable for further optimization of pharmacological and ADMET properties.
authors.affiliation: Department of Chemistry, Wichita State University, Wichita, KS 67260, USA.
authors.forename: Dengfeng
authors.initials: D
authors.lastname: Dou
authors.forename: Kok-Chuan
authors.initials: KC
authors.lastname: Tiew
authors.forename: Sivakoteswara Rao
authors.initials: SR
authors.lastname: Mandadapu
authors.forename: Mallikarjuna Reddy
authors.initials: MR
authors.lastname: Gunnam
authors.forename: Kevin R
authors.initials: KR
authors.lastname: Alliston
authors.forename: Yunjeong
authors.initials: Y
authors.lastname: Kim
authors.forename: Kyeong-Ok
authors.initials: KO
authors.lastname: Chang
authors.forename: William C
authors.initials: WC
authors.lastname: Groutas
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D017250:Caliciviridae Infections / Q000188:drug therapy; D002460:Cell Line; D015195:Drug Design; D006801:Humans; D029322:Norovirus / Q000187:drug effects*; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000596:Amino Acids; D000998:Antiviral Agents; D013449:Sulfonamides