title: Hypercalcemia due to subcutaneous fat necrosis in a newborn after total body cooling.
abstract: Subcutaneous fat necrosis is an inflammatory disorder of adipose tissue. Although patients need long-term follow-up to prevent hypercalcemia, the prognosis is generally favorable. We herein present a case of a newborn who developed subcutaneous fat necrosis-related hypercalcemia after hypothermia treatment for hypoxic ischemic encephalopathy. Widespread use of hypothermia treatment for hypoxic ischemic encephalopathy in the neonatal intensive care unit may increase the risk of developing subcutaneous fat necrosis and subsequently hypercalcemia. Great care should be taken to recognize skin findings early in newborns receiving hypothermia treatment, and those diagnosed with subcutaneous fat necrosis require close follow-up because they are at risk for developing hypercalcemia.
authors.affiliation: Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Akcay
authors.forename: Melek
authors.initials: M
authors.lastname: Akar
authors.forename: M Yekta
authors.initials: MY
authors.lastname: Oncel
authors.forename: Avidan
authors.initials: A
authors.lastname: Kızılelma
authors.forename: Omer
authors.initials: O
authors.lastname: Erdeve
authors.forename: S Suna
authors.initials: SS
authors.lastname: Oguz
authors.forename: Nurdan
authors.initials: N
authors.lastname: Uras
authors.forename: Ugur
authors.initials: U
authors.lastname: Dılmen
mesh_terms: D001707:Biopsy, Needle; D004359:Drug Therapy, Combination; D005218:Fat Necrosis / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006934:Hypercalcemia / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D007036:Hypothermia, Induced / Q000009:adverse effects* / Q000379:methods; D020925:Hypoxia-Ischemia, Brain / Q000175:diagnosis / Q000628:therapy*; D007150:Immunohistochemistry; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal; D018570:Risk Assessment; D012720:Severity of Illness Index; D050151:Subcutaneous Fat / Q000473:pathology*; D016896:Treatment Outcome