title: Functional role of T-type calcium channels in tumour growth and progression: prospective in cancer therapy.
abstract: T-type Ca²⁺ channels represent a specific channel family overexpressed in different types of tumours. Their involvement in controlling the proliferation, angiogenesis and invasion of tumour cells, has been partially clarified. The article by Zhang et al. in this issue of BJP provides the first evidence of anti-tumoural effects of endostatin (ES) in U87 glioma cells. He demonstrated that ES or mibefradil (a L/T-type calcium channel blocker), reduces the proliferation and migration of U87 glioma cells in a T-type Ca²⁺ channel-dependent manner. However, the difference in the blocking effect of mibefradil on T-type calcium channel expression as compared with its ability to inhibit proliferation and migration, supports the idea of a broader T/L-type-independent effect of the mibefradil blocker. Overall, these findings provide new insights for the future development of a novel class of anti-T-type calcium channel blockers in the therapy of glioblastoma.
authors.affiliation: School of Pharmacy, Section of Experimental Medicine, University of Camerino, Camerino (MC), Italy. giorgio.santoni@unicam.it
authors.forename: Giorgio
authors.initials: G
authors.lastname: Santoni
authors.forename: Matteo
authors.initials: M
authors.lastname: Santoni
authors.forename: Massimo
authors.initials: M
authors.lastname: Nabissi
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D020747:Calcium Channels, T-Type / Q000737:chemistry*; D002465:Cell Movement / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects*; D043169:Endostatins / Q000494:pharmacology*; D005909:Glioblastoma / Q000188:drug therapy*; D006801:Humans
chemical_list: D000970:Antineoplastic Agents; D002121:Calcium Channel Blockers; D020747:Calcium Channels, T-Type; D043169:Endostatins