title: Nanoparticles act as protein carriers during cellular internalization.
abstract: Two-colour fluorescence microscopy was used to track the cellular internalization of nanoparticles exposed to extracellular serum proteins. Single particle tracking revealed that nanoparticles and serum proteins are internalized and transported through the cell as a single complex. This study demonstrates the importance of nanoparticle-protein interactions in cellular applications.
authors.affiliation: School of Chemistry and Biochemistry and Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, 901 Atlantic Drive, Atlanta, Georgia 30332, USA.
authors.forename: Gerard W
authors.initials: GW
authors.lastname: Doorley
authors.forename: Christine K
authors.initials: CK
authors.lastname: Payne
mesh_terms: D000818:Animals; D002232:Carbocyanines / Q000737:chemistry / Q000378:metabolism; D002460:Cell Line; D004337:Drug Carriers / Q000737:chemistry / Q000378:metabolism*; D004705:Endocytosis; D005456:Fluorescent Dyes / Q000737:chemistry / Q000378:metabolism; D000882:Haplorhini; D008856:Microscopy, Fluorescence; D053758:Nanoparticles / Q000737:chemistry; D012710:Serum Albumin, Bovine / Q000737:chemistry / Q000378:metabolism*
chemical_list: C569686:Alexa Fluor 647; D002232:Carbocyanines; D004337:Drug Carriers; D005456:Fluorescent Dyes; D012710:Serum Albumin, Bovine