title: [Clinical characteristics of acute encephalopathies associated with influenza H1N1-2009 in children].
abstract: We report 12 cases of acute encephalopathy associated with influenza H1N1-2009 treated according to Japanese guideline (2009). In all 12 cases, electroencephalogram presented diffuse or localized high-amplitude slow waves. Brain CT and MRI showed abnormalities in 4 and 6 cases, respectively. We used hypothermia therapy for 5 patients. One patient showed impairment in short term memory, while the rest of the patients showed no sequelae. These 12 cases presented here suggest the early recognition and therapy according to the newly proposed guideline may reduce severe sequelae and mortality by acute encephalopathy associated with influenza H1N1-2009.
authors.affiliation: Division of Neurology, Kanagawa Children's Medical Center, Yokohama, Kanagawa. nabe11@aol.com
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Watanabe
authors.forename: Megumi
authors.initials: M
authors.lastname: Tsuji
authors.forename: Kiyoko
authors.initials: K
authors.lastname: Sameshima
authors.forename: Takahito
authors.initials: T
authors.lastname: Wada
authors.forename: Mizue
authors.initials: M
authors.lastname: Iai
authors.forename: Sumimasa
authors.initials: S
authors.lastname: Yamashita
authors.forename: Takuya
authors.initials: T
authors.lastname: Hayashi
authors.forename: Noriko
authors.initials: N
authors.lastname: Aida
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Osaka
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000998:Antiviral Agents / Q000008:administration & dosage; D002648:Child; D002675:Child, Preschool; D016572:Cyclosporine / Q000008:administration & dosage; D004660:Encephalitis / Q000175:diagnosis / Q000628:therapy* / Q000821:virology*; D005260:Female; D006801:Humans; D007036:Hypothermia, Induced; D007223:Infant; D053118:Influenza A Virus, H1N1 Subtype; D007251:Influenza, Human / Q000150:complications*; D018810:Magnetic Resonance Angiography; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage; D017410:Practice Guidelines as Topic; D020551:Pulse Therapy, Drug; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D016572:Cyclosporine; D008775:Methylprednisolone