title: [Pregnancy outcomes of patients with polycystic ovary syndrome undergoing in vitro fertilization and embryo transfer].
abstract: OBJECTIVE
  To study pregnant outcomes of patients with polycystic ovary syndrome (PCOS) undergoing in vitro fertilization and embryo transfer (IVF-ET), and analyze the differences of pregnant outcomes in patients with various phenotypes of PCOS.
  
  
  METHODS
  From Jan. 2005 to Feb. 2010, 631 PCOS patients (PCOS group) and 1423 patients with tubal infertility (control group) who underwent IVF-ET with matched age and body mass index were selected in Center for Reproductive Medicine of the Provincial Hospital Affiliated to Shandong University. Retrospective study was carried out, and pregnancy outcomes were compared between two groups.
  
  
  RESULTS
  The rates of abortion and preterm birth in PCOS group were significantly higher than those in control group [22.7% (143/631) vs. 18.69% (266/1423) and 11.2% (38/339) vs. 6.4% (51/794) respectively, all P < 0.05]. The rates of gestational diabetes mellitus were 1.5% (5/339) in PCOS and 0.6% (5/794) in control group, respectively; the rates of pregnancy induced hypertension syndrome were 4.7% (16/339) in PCOS and 3.0% (24/794) in control group; gestational days were (272 ± 13) days in PCOS and (273 ± 10) days in control group; the rates of neonatal deformity were 0.6% (2/339) in PCOS and 0.8% (6/794) in control group; weight of newborn infants in the two groups was (3.5 ± 0.5) kg; and there was no significant difference between two groups in the above index (all P > 0.05). Ovulatory PCOS patients had similar abortion rate [18.6% (19/102)] and preterm birth rate [8.2% (4/49)] when compared with those of control group (P > 0.05). Conversely, oligo-ovulatory PCOS patients showed higher abortion rate [23.4% (124/529)] and preterm birth rate [11.7% (34/290)] than those of control group (P < 0.05).
  
  
  CONCLUSIONS
  PCOS patients after IVF-ET have an increased abortion rate and preterm birth rate. However, ovulatory PCOS did not present various pregnancy complications. Non-polycystic ovary PCOS patients have worse pregnancy outcome. Ovarian dysfunction might be related to obstetric complications.
authors.affiliation: Center for Reproductive Medicine, Shandong University, Jinan, China.
authors.forename: Xue
authors.initials: X
authors.lastname: Yan
authors.forename: Yu-hua
authors.initials: YH
authors.lastname: Shi
authors.forename: Yan
authors.initials: Y
authors.lastname: Sheng
authors.forename: Rong
authors.initials: R
authors.lastname: Tang
authors.forename: Li-hong
authors.initials: LH
authors.lastname: Xu
authors.forename: Yuan
authors.initials: Y
authors.lastname: Li
authors.forename: Zi-jiang
authors.initials: ZJ
authors.lastname: Chen
mesh_terms: D000022:Abortion, Spontaneous / Q000453:epidemiology; D016640:Diabetes, Gestational / Q000453:epidemiology; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D066298:In Vitro Techniques; D007231:Infant, Newborn; D007247:Infertility, Female / Q000209:etiology / Q000628:therapy*; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000628:therapy*; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D016896:Treatment Outcome