title: The insulin and insulin-like growth factor receptor family in neoplasia: an update.
abstract: Although several early phase clinical trials raised enthusiasm for the use of insulin-like growth factor I receptor (IGF1R)-specific antibodies for cancer treatment, initial Phase III results in unselected patients have been disappointing. Further clinical studies may benefit from the use of predictive biomarkers to identify probable responders, the use of rational combination therapies and the consideration of alternative targeting strategies, such as ligand-specific antibodies and receptor-specific tyrosine kinase inhibitors. Targeting insulin and IGF signalling also needs to be considered in the broader context of the pathophysiology that relates obesity and diabetes to neoplasia, and the effects of anti-diabetic drugs, including metformin, on cancer risk and prognosis. The insulin and IGFI receptor family is also relevant to the development of PI3K-AKT pathway inhibitors.
authors.affiliation: Lady Davis Research Institute and McGill University, Montreal, Quebec H3T1E2, Canada. michael.pollak@mcgill.ca
authors.forename: Michael
authors.initials: M
authors.lastname: Pollak
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D005810:Multigene Family; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism*; D017451:Receptors, Somatomedin / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D007328:Insulin; D017451:Receptors, Somatomedin; D007334:Insulin-Like Growth Factor I