title: Ieodoglucomides A and B from a marine-derived bacterium Bacillus licheniformis.
abstract: Ieodoglucomides A (1) and B (2), unique glycolipopeptides consisting of an amino acid, a new fatty acid, a succinic acid, and a sugar, were isolated from a Marine-derived bacterium Bacillus licheniformis. The absolute stereochemistry of 1 and 2 was determined by deploying coupling constants, Marfey's and Mosher's methods, and literature reviews. Compounds 1 and 2 displayed moderate in vitro antimicrobial activity. Furthermore, ieodoglucomide B (2) exhibited cytotoxic activity against lung cancer and stomach cancer cell lines with GI(50) values of 25.18 and 17.78 μg/mL, respectively.
authors.affiliation: Department of Marine Biotechnology, University of Science and Technology, 217 Gajungro, Yuseong-gu, Daejeon, Republic of Korea.
authors.forename: Fakir Shahidullah
authors.initials: FS
authors.lastname: Tareq
authors.forename: Ji Hye
authors.initials: JH
authors.lastname: Kim
authors.forename: Min Ah
authors.initials: MA
authors.lastname: Lee
authors.forename: Hyi-Seung
authors.initials: HS
authors.lastname: Lee
authors.forename: Yeon-Ju
authors.initials: YJ
authors.lastname: Lee
authors.forename: Jong Seok
authors.initials: JS
authors.lastname: Lee
authors.forename: Hee Jae
authors.initials: HJ
authors.lastname: Shin
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001407:Bacillus / Q000737:chemistry; D004354:Drug Screening Assays, Antitumor; D006001:Glycoconjugates / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D008386:Marine Biology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D000970:Antineoplastic Agents; D006001:Glycoconjugates; C572529:ieodoglucomide A; C572530:ieodoglucomide B