title: Kramecyne--a new anti-inflammatory compound isolated from Krameria cytisoides.
abstract: In the present work we describe the structure and anti-inflammatory activity of a new compound, kramecyne, isolated from a methanol extract of Krameria cytisoides (Krameriaceae). The structure of kramecyne was determined by IR, NMR, MS, and elemental analysis, which indicated that the structure corresponded to a hexamer of cyclic peroxide monomers. This compound exhibited good anti-inflammatory activity in the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema (51.8 ± 6.9% inhibition) and carrageenan-induced rat paw edema models at doses of 50 mg/kg. The compound significantly reduced edema to 63.1% after 1.0 h, and the effect was unchanged for 5 h. Kramecyne did not present acute toxicity, even at doses of 5,000 mg/kg.
authors.affiliation: Departamento de Sistemas Biológicos, Universidad Autónoma Metropolitana-Xochimilco, Calzada del Hueso 1100, Col. Villa Quietud, Coyoacan C.P. 04960, D.F.A.P. 23-181, Mexico.
authors.forename: Salud
authors.initials: S
authors.lastname: Pérez-Gutiérrez
authors.forename: Ernesto
authors.initials: E
authors.lastname: Sánchez-Mendoza
authors.forename: Diana
authors.initials: D
authors.lastname: Martínez-González
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Zavala-Sánchez
authors.forename: Cuauhtemoc
authors.initials: C
authors.lastname: Pérez-González
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000494:pharmacology*; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D004988:Ethers, Cyclic / Q000737:chemistry* / Q000494:pharmacology*; D031326:Krameriaceae / Q000737:chemistry*; D008297:Male; D051379:Mice; D010545:Peroxides / Q000737:chemistry* / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship
chemical_list: D000893:Anti-Inflammatory Agents; D004988:Ethers, Cyclic; D010545:Peroxides; D010936:Plant Extracts; C000596369:kramecyne