title: Angiogenesis inhibition using an oncolytic herpes simplex virus expressing endostatin in a murine lung cancer model.
abstract: Herpes-mediated viral oncolysis alone is not sufficient to completely eradicate tumors. In this study we used a replication conditional, endostatin-expressing herpes simplex virus-1 mutant (HSV-Endo) in a murine lung cancer model. We hypothesized that the anti-angiogenic action of endostatin would improve upon the oncolytic effect of HSV-1. HSV-Endo was evaluated in a pulmonary metastases and orthotopic flank model, where there was significantly less tumor burden and reduced microvessel density compared to a control virus. Endostatin expression appears to improve the anti-tumor effect of HSV-1 in a lung cancer model.
authors.affiliation: Division of Thoracic Surgery, Massachusetts General Hospital Cancer Center, Boston, USA.
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Goodwin
authors.forename: Anthony D
authors.initials: AD
authors.lastname: Schmitt
authors.forename: Christopher M
authors.initials: CM
authors.lastname: McGinn
authors.forename: Bryan C
authors.initials: BC
authors.lastname: Fuchs
authors.forename: Darshini
authors.initials: D
authors.lastname: Kuruppu
authors.forename: Kenneth K
authors.initials: KK
authors.lastname: Tanabe
authors.forename: Michael
authors.initials: M
authors.lastname: Lanuti
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D004195:Disease Models, Animal; D043169:Endostatins / Q000235:genetics*; D042783:Endothelial Cells / Q000502:physiology; D008175:Lung Neoplasms / Q000098:blood supply* / Q000517:prevention & control / Q000556:secondary; D051379:Mice; D008807:Mice, Inbred BALB C; D009389:Neovascularization, Pathologic / Q000628:therapy*; D050130:Oncolytic Virotherapy / Q000379:methods*; D018139:Simplexvirus / Q000235:genetics*; D019076:Transgenes
chemical_list: D043169:Endostatins