title: Acute and late toxicities of radiotherapy for patients with discoid lupus erythematosus: a retrospective case-control study.
abstract: BACKGROUND
  The purpose of this study was to evaluate acute and late toxicities of radiotherapy for patients with discoid lupus erythematosus (DLE).
  
  
  METHODS
  A retrospective review was performed of patients with DLE who received radiotherapy at our institution between 1980 and 2005. Patients with other connective tissue disorders were excluded. Control patients were matched 2:1 with the DLE treatment courses based on age, cancer diagnosis, year of treatment, radiotherapy dose, and sex. Acute (within 30 days from the completion of radiotherapy) and late toxicities were evaluated for each treatment course using the Common Terminology Criteria for Adverse Events Version 3.0.
  
  
  RESULTS
  Twelve patients with DLE received a total of 15 radiotherapy courses. The median follow-up time was 2.6 years (range, 0.0-15.2 years). Acute toxicity of any organ was observed in 10 (67%) treatment courses, of which 2 (13%) were Grade 3 or higher. Acute Grade 1 or 2 dermatologic toxicity was observed in 8 courses (53%). Late toxicity of any organ was observed in 7 of 12 (58%) evaluable treatment courses, of which 3 (23%) were grade 3 or higher. Late grade 1 or 2 dermatologic toxicity was observed in 5 (42%) courses. No patient experienced acute or late Grade 3 or higher dermatologic toxicity. The rates of any organ or dermatologic acute and late toxicity were not significantly different between DLE and control treatment courses.
  
  
  CONCLUSIONS
  Our findings do not suggest an increased risk of toxicity to the skin or other organs in patients with DLE receiving radiotherapy.
authors.affiliation: Department of Radiation Oncology, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA.
authors.forename: Ajaykumar B
authors.initials: AB
authors.lastname: Patel
authors.forename: Christopher L
authors.initials: CL
authors.lastname: Hallemeier
authors.forename: Ivy A
authors.initials: IA
authors.lastname: Petersen
authors.forename: Ashley W
authors.initials: AW
authors.lastname: Jensen
authors.forename: Thomas G
authors.initials: TG
authors.lastname: Osborn
authors.forename: Robert C
authors.initials: RC
authors.lastname: Miller
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008179:Lupus Erythematosus, Discoid / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D011832:Radiation Injuries / Q000209:etiology* / Q000401:mortality*; D011879:Radiotherapy Dosage; D020266:Radiotherapy, Conformal / Q000009:adverse effects*; D012189:Retrospective Studies; D015996:Survival Rate