title: [Immune reactions to and side effects of a vaccination against paratuberculosis in milk goats].
abstract: OBJECTIVE
  The aim of this study was to investigate the local and systemic reactions of goats to a vaccination with Gudair® against Johne's Disease.
  
  
  METHODS
  In a herd of 280 goats, 182 individual animals were tested serologically before and after vaccination with Gudair®. In a group of 40 animals (consisting of 10 kids, 10 one-year-olds and 20 adult females) the following parameters were documented: rectal temperature, skin thickness and pain at the injection site, feed intake and milk production. In addition, these 40 animals were tested serologically with ELISA on days 0, 15, 28 and 84.
  
  
  RESULTS
  Rectal temperature increased significantly (p<0.0056) on day 15 in one-year-old animals and on day8 in adult goats. All 40 test animals showed skin reactions at the injection site. Skin thickness remained significantly increased (p<0.0056) during the entire period of investigation. The increase in skin thickness was significantly higher in adult goats than in kids and one-year-old goats. Three out of 40 animals had necrosis at the injection site. During the initial days after vaccination, 10 out of 40 individual animals showed pain and in six goats feed intake was decreased. Before the vaccination, 12% of the total herd was serologically paratuberculosis-positive in the ELISA test and after the vaccination 95%.
  
  
  CONCLUSIONS
  Gudair® causes severe local reactions and a systemic response.
  
  
  CONCLUSIONS
  Due to the severe skin reactions, the choice of injection site should depend on management practices. Goats which are secured in the milking parlour should not be vaccinated in the neck.
authors.affiliation: Klinik für kleine Klauentiere, Stiftung Tierärztliche Hochschule Hannover. angelika.stau@tiho-hannover.de
authors.forename: A
authors.initials: A
authors.lastname: Stau
authors.forename: M
authors.initials: M
authors.lastname: Ganter
mesh_terms: D000367:Age Factors; D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*; D001831:Body Temperature / Q000187:drug effects; D003612:Dairying; D004435:Eating / Q000187:drug effects; D005260:Female; D015511:Goat Diseases / Q000517:prevention & control*; D006041:Goats; D007279:Injections, Subcutaneous / Q000009:adverse effects / Q000662:veterinary; D007774:Lactation / Q000187:drug effects; D016927:Mycobacterium avium subsp. paratuberculosis / Q000276:immunology*; D010283:Paratuberculosis / Q000517:prevention & control*; D012867:Skin / Q000473:pathology; D014611:Vaccination / Q000009:adverse effects / Q000592:standards / Q000662:veterinary*
chemical_list: D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines