title: Treatment of congenital pulmonary airway malformation induced hydrops fetalis via percutaneous sclerotherapy.
abstract: Large type II and III congenital pulmonary airway malformations (CPAMs) can cause pulmonary hypoplasia, non-immune hydrops fetalis and fetal demise. Fetal intervention is indicated if hydrops fetalis develops. In this report, we describe three cases of type II and III CPAMs complicated by hydrops and treated with percutaneous sclerotherapy by ethanolamine injection into the tumor. All 3 cases demonstrated reduction in size of the CPAM and resolution of the hydrops with subsequent delivery at term. We believe that fetal percutaneous sclerotherapy can be used as a minimally invasive palliative strategy to treat CPAM-induced hydrops fetalis. Further studies are needed to delineate the risks of this novel technique.
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, Calif. 90027, USA.
authors.forename: Frances L
authors.initials: FL
authors.lastname: Lee
authors.forename: Nellie
authors.initials: N
authors.lastname: Said
authors.forename: Tracy C
authors.initials: TC
authors.lastname: Grikscheit
authors.forename: Cathy E
authors.initials: CE
authors.lastname: Shin
authors.forename: Arlyn
authors.initials: A
authors.lastname: Llanes
authors.forename: Ramen H
authors.initials: RH
authors.lastname: Chmait
mesh_terms: D000328:Adult; D015615:Cystic Adenomatoid Malformation of Lung, Congenital / Q000150:complications* / Q000000981:diagnostic imaging / Q000601:surgery; D019856:Ethanolamine / Q000008:administration & dosage; D005260:Female; D005865:Gestational Age; D006801:Humans; D015160:Hydrops Fetalis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology*; D007231:Infant, Newborn; D008168:Lung / Q000002:abnormalities / Q000196:embryology / Q000601:surgery; D008297:Male; D011247:Pregnancy; D015911:Sclerotherapy / Q000379:methods*; D016216:Ultrasonography, Prenatal
chemical_list: D019856:Ethanolamine