title: Correlation between the circulating bone markers and vitamin D in the healthy Thai people.
abstract: There are several circulating bone markers that are useful for physicians in determining the bone quality. The markers are composed of N-terminal propeptide of type I collagen (PINP) which determines the bone formation, undercarboxylated osteocalcin (UcOC) and N-mid fragment of osteocalcin (N-MID) which determines the bone remodeling, C-telopeptide of type I collagen (betaPCTx) or betacrosslap (betaCTx), pyridinoline (PYD) and deoxypyridinoline (DPD) which determines the bone resorption. The vitamin named vitamin D (VitD) also affects the bone property. However there is little information about the relationship of these biomarkers. In this experiment, the researchers investigated the correlation of the circulating biomarkers and found the correlations between UcOC and betaCTx (r = 0.471, p = 0.011), between UcOC and Vit D (r = 0.39, p = 0.04), between N-MID and PINP (r = 0.833, p = 0.000), between N-MID and PCTx (r = 0.641, p = 0.000) and lastly between PINP and betaCTx (r = 0.657, p = 0.000) in the male group whereas the correlations between UcOC and PYD (r = 0.318, p = 0.043), between UcOC and DPD (r = 0.551, p = 0.008), between N-MID and PINP (r = 0.721, p = 0.000), between N-MID and PCTx (r = 0.719, p = 0.000), between N-MID and PYD (r = 0.485, p = 0.001), between N-MID and Vit D (r = 0.347, p = 0.026), between PINP and JCTx (r = 0.632, p = 0.000), between PINP and PYD (r = 0.312, p = 0.047), between bCTx and PYD (r = 0.365, p = 0.019), between PYD and DPD (r = 0.567, p = 0.006) and lastly between PYD and Vit D (r = 0.409, p = 0.008) were found in the females. In addition, the new biomolecule named matrix Gla protein (MGP), a small protein produced by bone tissues was also investigated. The authors found the correlation between MGP and PYD (r = 0.468, p = 0.012) in the males and found the correlations between UcOC and MGP (r = 0.421, p = 0.006), between N-MID and MGP (r = 0.333, p = 0.033), between MGP and PYD (r = 0.471, p = 0.002), between MGP and DPD (r = 0.472, p = 0.026) in the female group.
authors.affiliation: Department of Pre-clinic and Applied Animal Science, Faculty of Veterinary Science, Mahidol University, Nakornpathom, Thailand.
authors.forename: Shutipen
authors.initials: S
authors.lastname: Buranasinsup
authors.forename: Arunee
authors.initials: A
authors.lastname: Jangsangthong
authors.forename: Narong
authors.initials: N
authors.lastname: Bunyaratavej
mesh_terms: D000328:Adult; D000596:Amino Acids / Q000097:blood; D002135:Calcium-Binding Proteins / Q000097:blood*; D003094:Collagen / Q000097:blood*; D016326:Extracellular Matrix Proteins / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood*; D011347:Procollagen / Q000097:blood*; D013785:Thailand; D014807:Vitamin D / Q000097:blood*; D000097568:Matrix Gla Protein
chemical_list: D000596:Amino Acids; D002135:Calcium-Binding Proteins; D003094:Collagen; D016326:Extracellular Matrix Proteins; D010446:Peptide Fragments; D011347:Procollagen; D014807:Vitamin D; D000097568:Matrix Gla Protein; C110762:glutamyl-lysyl-alanyl-histidyl-aspartyl-glycyl-glycyl-arginine; C047202:procollagen Type I N-terminal peptide; C015484:pyridinoline