title: Molecular imaging of disease with targeted contrast ultrasound imaging.
abstract: To enhance clinical care for patients, methods for noninvasive imaging of specific disease-related molecular changes are being developed to expand and improve diagnostic capabilities. These new techniques are used in research programs to characterize pathophysiology and as a surrogate end point for therapeutic efficacy. Molecular imaging with contrast-enhanced ultrasound relies on the detection of microbubbles or other acoustically active particulate agents that are targeted to and retained at sites of disease. This review describes the progress that has been made in the development and testing of methods for contrast ultrasound molecular imaging with a specific focus on cardiovascular disease. Specific topics addressed include probe development, detection methods, and specific biologic processes that are important in clinical cardiovascular medicine and that have been targeted with microbubble contrast agents.
authors.affiliation: Division of Cardiovascular Medicine, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd., Portland, OR 97239, USA.
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Inaba
authors.forename: Jonathan R
authors.initials: JR
authors.lastname: Lindner
mesh_terms: D054058:Acute Coronary Syndrome / Q000000981:diagnostic imaging; D000818:Animals; D050197:Atherosclerosis / Q000000981:diagnostic imaging; D015415:Biomarkers / Q000032:analysis; D002318:Cardiovascular Diseases / Q000000981:diagnostic imaging*; D003287:Contrast Media; D042241:Early Diagnosis; D006801:Humans; D007249:Inflammation / Q000000981:diagnostic imaging; D007962:Leukocytes / Q000000981:diagnostic imaging; D051379:Mice; D045423:Microbubbles; D057054:Molecular Imaging / Q000379:methods*; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging; D019007:P-Selectin; D011237:Predictive Value of Tests; D013927:Thrombosis / Q000000981:diagnostic imaging; D014463:Ultrasonography; D019010:Vascular Cell Adhesion Molecule-1
chemical_list: D015415:Biomarkers; D003287:Contrast Media; D019007:P-Selectin; D019010:Vascular Cell Adhesion Molecule-1