title: Carvedilol attenuates oxidative stress in chronic chagasic cardiomyopathy.
abstract: BACKGROUND
  There is increasing evidence suggesting that Chagas disease involves oxidative damage and contributes to heart disease progression.
  
  
  OBJECTIVE
  To evaluate the effect of carvedilol on oxidative stress markers in chronic Chagas disease.
  
  
  METHODS
  The study population included 42 patients with Chagas cardiomyopathy and oxidative stress biomarkers were measured before and after a period of six months of treatment with carvedilol (37.5 mg/day). Patients were considered according to the Los Andes classification and the activity of superoxide dismutase, catalase, glutathione peroxidase, S-transferase and reductase, myeloperoxidase and adenosine deaminase; levels of reduced glutathione, thiobarbituric acid reactive species, carbonyl protein, vitamin E and nitric oxide were measured in blood.
  
  
  RESULTS
  After treatment with carvedilol, all groups showed significant reductions in levels of carbonyl protein and reduced glutathione, whereas the levels of nitric oxide and adenosine activity increased significantly only in group IA. Moreover, most of the antioxidant enzymes showed decrease in activity in groups IA and IB.
  
  
  CONCLUSIONS
  The data suggest that treatment with carvedilol was effective in attenuating oxidative damage, an effect that may be particularly important in patients with chronic Chagas' disease cardiomyopathy.
authors.affiliation: Universidade Federal de Santa Catarina, SC, Brazil. budnip@gmail.com
authors.forename: Patrícia
authors.initials: P
authors.lastname: Budni
authors.forename: Roberto Coury
authors.initials: RC
authors.lastname: Pedrosa
authors.forename: Thais Regina
authors.initials: TR
authors.lastname: Garlet
authors.forename: Eduardo Monguilhott
authors.initials: EM
authors.lastname: Dalmarco
authors.forename: Juliana Bastos
authors.initials: JB
authors.lastname: Dalmarco
authors.forename: Manuel Rosa de Oliveira
authors.initials: MR
authors.lastname: Lino
authors.forename: Edésio Luiz
authors.initials: EL
authors.lastname: Simionato
authors.forename: Jorge Antônio
authors.initials: JA
authors.lastname: Amara
authors.forename: Tânia Sílvia
authors.initials: TS
authors.lastname: Frode
authors.forename: Danilo
authors.initials: D
authors.lastname: Wilhelm Filho
mesh_terms: D000243:Adenosine Deaminase / Q000378:metabolism; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D000975:Antioxidants / Q000494:pharmacology*; D015415:Biomarkers / Q000378:metabolism; D002227:Carbazoles / Q000494:pharmacology*; D000077261:Carvedilol; D002598:Chagas Cardiomyopathy / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D011412:Propanolamines / Q000494:pharmacology*; D011446:Prospective Studies; D050050:Protein Carbonylation / Q000187:drug effects
chemical_list: D000319:Adrenergic beta-Antagonists; D000975:Antioxidants; D015415:Biomarkers; D002227:Carbazoles; D011412:Propanolamines; D000077261:Carvedilol; D009569:Nitric Oxide; D000243:Adenosine Deaminase; D005978:Glutathione