title: Synthesis of azaphilone-based chemical libraries.
abstract: The synthesis of azaphilone scaffolds that have been further diversified by cross coupling acylation and amine addition is reported. Methodology development also led to novel modifications including C5 acetoxylation and condensations producing isoquinolin-6(7H) structures. Overall, the library synthesis afforded three azaphilone sublibraries, including vinylogous pyridones which project diversity elements in four sectors of the azaphilone core.
authors.affiliation: Department of Chemistry, Boston University, Massachusetts 02215, United States.
authors.forename: Mathieu
authors.initials: M
authors.lastname: Achard
authors.forename: Aaron B
authors.initials: AB
authors.lastname: Beeler
authors.forename: John A
authors.initials: JA
authors.lastname: Porco
mesh_terms: D001578:Benzopyrans / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D010860:Pigments, Biological / Q000737:chemistry*; D054852:Small Molecule Libraries / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001578:Benzopyrans; D010860:Pigments, Biological; D054852:Small Molecule Libraries; C494154:azaphilone