title: Pectus carinatum--first ultrastructural findings of a potential metabolic lesion.
abstract: The histological and ultrastructural findings of rib specimens after two re-interventions in the case of recurrence of pectus carinatum (PC) are presented in this report. A 15-year-old boy developed recurrences of mild PC after re-chondroplasties using the Ravitch technique. Histological study of the resected cartilage showed markedly degenerative changes of the sternocostal cartilage. For the first time, intracellular crystalline inclusions in some of the chondrocytes were found. These findings indicate metabolic changes as a possible pathogenetic parameter in PC.
authors.affiliation: Institute of Pathology, University Medical Centre Mainz, Mainz, Germany. brochhausen@pathologie.klinik.uni-mainz.de
authors.forename: Christoph
authors.initials: C
authors.lastname: Brochhausen
authors.forename: Felix Karl P
authors.initials: FK
authors.lastname: Müller
authors.forename: Salmai
authors.initials: S
authors.lastname: Turial
authors.forename: C
authors.initials: C
authors.lastname: James Kirkpatrick
mesh_terms: D000293:Adolescent; D001848:Bone Diseases, Developmental / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D002358:Cartilage, Articular / Q000378:metabolism / Q000648:ultrastructure; D019902:Chondrocytes / Q000378:metabolism / Q000648:ultrastructure; D003460:Crystallization; D006801:Humans; D002479:Inclusion Bodies / Q000378:metabolism / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D012008:Recurrence; D013249:Sternum / Q000002:abnormalities* / Q000601:surgery / Q000648:ultrastructure