title: [Effect of amino acid and glucose infusion on perioperative body temperature and postoperative infection in patients undergoing total knee arthroplasty].
abstract: BACKGROUND
  We investigated whether the perioperative amino acid infusion with glucose is effective for preventing perioperative hypothermia and postoperative infection in patients undregoing total knee arthroplasty (TKA).
  
  
  METHODS
  Forty patients undergoing TKA under general anesthesia were enrolled in this study. The patients were randomly allocated to two groups: AA group (n = 22), to which amino acid was infused, and AAGlu group (n = 18), to which amino acid and glucose were infused. The infusions were started before the anesthetic induction. Remifentanil was administered during the surgery, and the dose of remifentanil was adjusted to keep stable hemodynamics. The levels of blood glucose and body temperature were evaluated. We also recorded the frequency of additional use of nonsteroidal anti-inflammatory drugs, the days required until the wound closure, and complications in the post-operative period.
  
  
  RESULTS
  The levels of blood glucose in AAGlu group were significantly higher than those of AA group (P < 0.05). However, no significant differences were found in perioperative body temperature, postoperative days required until the wound closure and the frequency of additional use of analgesics between the groups.
  
  
  CONCLUSIONS
  These results suggest that in patients undergoing TKA receiveing amino acid infusion perioperatively, thermogenic effect and prevention of postoperative infection are similar whether exogenous glucose is infused or not.
authors.affiliation: Department of Anesthesiology, Saiseikai Nakatsu Hospital, Osaka 530-0012.
authors.forename: Yasuki
authors.initials: Y
authors.lastname: Fujita
authors.forename: Sayo
authors.initials: S
authors.lastname: Yamaguchi
authors.forename: Kayo
authors.initials: K
authors.lastname: Nakamura
authors.forename: Yuu
authors.initials: Y
authors.lastname: Horiguchi
authors.forename: Daisuke
authors.initials: D
authors.lastname: Ikeda
authors.forename: Michiko
authors.initials: M
authors.lastname: Kaneko
authors.forename: Keiko
authors.initials: K
authors.lastname: Tomioka
authors.forename: Chiharu
authors.initials: C
authors.lastname: Tokunaga
authors.forename: Takeo
authors.initials: T
authors.lastname: Iwakura
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000596:Amino Acids / Q000008:administration & dosage*; D000768:Anesthesia, General; D019645:Arthroplasty, Replacement, Knee; D005260:Female; D005947:Glucose / Q000008:administration & dosage*; D006801:Humans; D007035:Hypothermia / Q000517:prevention & control*; D007431:Intraoperative Complications / Q000517:prevention & control*; D008297:Male; D019990:Perioperative Care; D013530:Surgical Wound Infection / Q000517:prevention & control*
chemical_list: D000596:Amino Acids; D005947:Glucose