title: The risk of a persistent glucose metabolism impairment after gestational diabetes mellitus is increased in patients with polycystic ovary syndrome.
abstract: OBJECTIVE
  To test the hypothesis that the risk of persistent glucose impairment after gestational diabetes mellitus (GDM) is increased in patients with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  The prospective case-control study included 42 pregnant patients with PCOS and GDM and 84 pregnant control patients with GDM but without clinical and biochemical hyperandrogenism, polycystic ovaries, and oligo-anovulation. The case and control subjects were matched one to two for age and BMI. The glycemic profiles were studied in all subjects 6 weeks, 12 weeks, and 18 months after delivery. The incidence and the relative risk (RR) were calculated for overall persistence of an abnormal glycemic pattern and for each specific alteration, i.e., impaired glucose tolerance (IGT), impaired fasting glucose (IFG), and diabetes mellitus (DM).
  
  
  RESULTS
  At 18 months after delivery, the incidences of IFG, IGT, and IFG-IGT were significantly (P < 0.05) higher in the cases than in the controls. At the 18-month follow-up, the RR for the composite outcome of glucose metabolism impairment in PCOS women was 3.45 (95% CI 1.82-6.58).
  
  
  CONCLUSIONS
  Patients with PCOS are at increased risk for a persistent impaired glucose metabolism after GDM.
authors.affiliation: Department of Obstetrics and Gynecology, Magna Graecia University of Catanzaro, Catanzaro, Italy. stefanopalomba@tin.it
authors.forename: Stefano
authors.initials: S
authors.lastname: Palomba
authors.forename: Angela
authors.initials: A
authors.lastname: Falbo
authors.forename: Tiziana
authors.initials: T
authors.lastname: Russo
authors.forename: Laura
authors.initials: L
authors.lastname: Rivoli
authors.forename: Marcello
authors.initials: M
authors.lastname: Orio
authors.forename: Andrea Gregorio
authors.initials: AG
authors.lastname: Cosco
authors.forename: Raffaella
authors.initials: R
authors.lastname: Vero
authors.forename: Carmelo
authors.initials: C
authors.lastname: Capula
authors.forename: Achille
authors.initials: A
authors.lastname: Tolino
authors.forename: Fulvio
authors.initials: F
authors.lastname: Zullo
authors.forename: Annamaria
authors.initials: A
authors.lastname: Colao
authors.forename: Francesco
authors.initials: F
authors.lastname: Orio
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D016022:Case-Control Studies; D016640:Diabetes, Gestational / Q000097:blood / Q000453:epidemiology / Q000378:metabolism* / Q000534:rehabilitation; D005260:Female; D005500:Follow-Up Studies; D018149:Glucose Intolerance / Q000453:epidemiology / Q000209:etiology*; D005951:Glucose Tolerance Test; D006801:Humans; D015994:Incidence; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications* / Q000453:epidemiology / Q000378:metabolism*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000453:epidemiology / Q000378:metabolism / Q000534:rehabilitation; D012307:Risk Factors; D055815:Young Adult
chemical_list: D001786:Blood Glucose