title: Neonatal diuretic therapy: furosemide, thiazides, and spironolactone.
abstract: Diuretics are commonly used to treat infants with oxygen-dependent chronic lung disease. However, there are limited data suggesting a beneficial effect of long-term diuretic therapy on pulmonary function or clinical outcome in this population. Furthermore, data available for review were primarily obtained before the widespread use of antenatal steroids or surfactant replacement therapy, before recognition of the new bronchopulmonary dysplasia. If used in this population, limitations of diuretic therapy as well as significant side effects need to be understood and a rationale approach to clinical use developed on a patient-centered basis.
authors.affiliation: Division of Neonatology, Department of Pediatrics, University of Iowa Children's Hospital, 200 Hawkins Drive, Iowa City, IA 52242, USA. jeffrey-segar@uiowa.edu
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Segar
mesh_terms: D001997:Bronchopulmonary Dysplasia / Q000188:drug therapy; D004232:Diuretics / Q000009:adverse effects / Q000627:therapeutic use*; D004374:Ductus Arteriosus, Patent / Q000188:drug therapy* / Q000503:physiopathology; D005665:Furosemide / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000188:drug therapy / Q000503:physiopathology; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000188:drug therapy / Q000503:physiopathology; D007668:Kidney / Q000196:embryology; D007677:Kidney Function Tests; D008171:Lung Diseases / Q000188:drug therapy* / Q000503:physiopathology; D012129:Respiratory Function Tests; D013148:Spironolactone / Q000009:adverse effects / Q000627:therapeutic use*; D049971:Thiazides / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D004232:Diuretics; D049971:Thiazides; D013148:Spironolactone; D005665:Furosemide