title: Thein utero initiation with DMN alters the complement of cytosolic glutathione S-transferases and the phenobarbital-induced expression ofc-jun andc-myc oncogenes in primary neonatal rat hepatocytes.
abstract: As revealed by a novelin utero-in vitro hepatocarcinogenesis model, a single exposure to dimethylnitrosamine (DMN) elicited in postnatal (and fetal) primary rat hepatocytes (i) immunocytochemically detectable, widespread increases in their complement of thealpha, mu and especiallypi classes of cytosolic glutathione S-transferases (GST's); and (ii) changed patterns (with respect to controls) of the phenobarbital (PB)-evoked increases in steady state levels ofc-jun andc-myc mRNA's. These results indicate that DMN causes both transient cytotoxic effects and a broad, permanent initiation in fetal proliferating hepatocytes.
authors.affiliation: Institute of Anatomy & Histology School of Medicine, The University of Verona, Strada Le Grazie 8, I-37134, Verona, Italy.
authors.forename: U
authors.initials: U
authors.lastname: Armato
authors.forename: J
authors.initials: J
authors.lastname: Wu
authors.forename: M
authors.initials: M
authors.lastname: Menegazzi
authors.forename: L
authors.initials: L
authors.lastname: Menapace
authors.forename: M
authors.initials: M
authors.lastname: Ribecco
authors.forename: L
authors.initials: L
authors.lastname: Testolin
authors.forename: A
authors.initials: A
authors.lastname: Carcereri De Prati
authors.forename: H
authors.initials: H
authors.lastname: Suzuki