title: The dynamic chromatographic behavior of tri-o-thymotide on HPLC chiral stationary phases.
abstract: The interconverting stereoisomers of tri-o-thymotide have been separated by HPLC on chiral stationary phases and the temperature dependence of the dynamic chromatographic patterns has been interpreted in terms of exchange between enantiomeric propeller and helical conformations. Computed low energy structures and CD spectra were used in absolute configuration assignment.
authors.affiliation: Sapienza Università di Roma, Dipartimento di Chimica e Tecnologie del Farmaco, P.le A. Moro 5, 00185, Rome, Italy.
authors.forename: Stefano Levi
authors.initials: SL
authors.lastname: Mortera
authors.forename: Rocchina
authors.initials: R
authors.lastname: Sabia
authors.forename: Marco
authors.initials: M
authors.lastname: Pierini
authors.forename: Francesco
authors.initials: F
authors.lastname: Gasparrini
authors.forename: Claudio
authors.initials: C
authors.lastname: Villani
mesh_terms: D002851:Chromatography, High Pressure Liquid; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification; D008968:Molecular Conformation; D011789:Quantum Theory; D013237:Stereoisomerism; D013816:Thermodynamics
chemical_list: D007783:Lactones; C120665:tri-o-thymotide