title: Serum prolactin level in patients with relapsing-remitting multiple sclerosis during relapse.
abstract: It has been hypothesized that hyperprolactinemia may contribute to the pathogenesis of multiple sclerosis (MS). In a case-control study, 58 patients with definite relapsing-remitting MS (RRMS) during relapse and 58 sex-matched and age-matched healthy controls were assessed for serum prolactin (PRL) concentration. Mean serum PRL levels (± standard deviation) were significantly higher in patients with MS (501.3 ± 232.6 mIU/L) than in healthy control patients (233.3 ± 142.7 mIU/L; p < 0.0001). Furthermore, these differences were consistent in each sex: females with MS (704.4 ± 119.6 mIU/L) compared to female controls (305.5 ± 156.9 mIU/L p < 0.001); and in males with MS (358.0 ± 180.0 mIU/L) compared to male controls (182.3 ± 107.5 mIU/L; p < 0.001). Our findings provided more evidence to support the hypothesis that patients with RRMS, regardless of gender, are in a hyperprolactinemic state.
authors.affiliation: Department of Neurology, 31151 Shahid Beheshti University of Medical Sciences, Logman Hospital, South Kargar Avenue, Kamali Street, Makhsus Alley, Tehran 13336, Iran. Sasan_moshir@yahoo.com
authors.forename: Sasan
authors.initials: S
authors.lastname: Moshirzadeh
authors.forename: Kourosh
authors.initials: K
authors.lastname: Ghareghozli
authors.forename: Ali Amini
authors.initials: AA
authors.lastname: Harandi
authors.forename: Hossien
authors.initials: H
authors.lastname: Pakdaman
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood / Q000150:complications; D008297:Male; D008875:Middle Aged; D020529:Multiple Sclerosis, Relapsing-Remitting / Q000097:blood* / Q000150:complications; D011388:Prolactin / Q000097:blood*; D055815:Young Adult
chemical_list: D011388:Prolactin