title: [The influential factors and clinical significance of acute renal failure complicated to orthotopic liver transplantation].
abstract: OBJECTIVE
  To analyze the risk factors for acute renal failure (ARF) early after liver transplantation.
  
  
  METHODS
  The data of 362 patients undergoing liver transplantation from August 2000 to December 2010 were retrospectively analyzed, including 71 patients with ARF (ARF group) and 291 without ARF (non-ARF group). Thirty-six variables, including clinical and experimental variables, were analyzed by t test for continuous variables and χ(2) test for discrete variables. The variables with significance (P < 0.05) were then analyzed with Stepwise logistic regression.
  
  
  RESULTS
  Twelve variables, including pretransplant serum creatinine, hemoglobin, thrombinogen activity, total bilirubin, MELD scores, total operation time, intraoperative blood loss, intraoperative blood transfusion, preoperative urine output, preoperative hepatic encephalopathy, intraoperative low blood pressure and postoperative infection, had significant difference between two groups (F = 10.30 - 182.70, P = 0.000 - 0.041). The Stepwise logistic regression analysis for 12 variables demonstrated that the high level of pretransplant serum creatinine, the low pretransplant thrombinogen activity, the high MELD scores, the large volume of intraoperative blood loss, postoperative infection were the independent risk factors of ARF complicated to orthotopic liver transplantation (P < 0.05).
  
  
  CONCLUSIONS
  Early ARF is a key negative factor for the survivors after orthotopic liver transplantation. The reason for ARF complicated to OLT is multiple. The high level of pretransplant serum creatinine, the low pretransplant thrombinogen activity, the high MELD scores, the large volume of intraoperative blood loss, postoperative infection were the independent risk factors of ARF complicated to orthotopic liver transplantation.
authors.affiliation: Department of General Surgery, Peking University Third Hospital, Beijing 100191, China. ychdoctor@163.com
authors.forename: Chun-hui
authors.initials: CH
authors.lastname: Yuan
authors.forename: Dian-rong
authors.initials: DR
authors.lastname: Xiu
authors.forename: Bin
authors.initials: B
authors.lastname: Jiang
authors.forename: Zhi-fei
authors.initials: ZF
authors.lastname: Li
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.forename: Shi-bing
authors.initials: SB
authors.lastname: Song
authors.forename: Tong-lin
authors.initials: TL
authors.lastname: Zhang
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology*; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult