title: Resting neural activity patterns in auditory brainstem and midbrain in conductive hearing loss.
abstract: CONCLUSIONS
  Conductive hearing loss (CHL) lowers resting neural activity patterns in the auditory periphery. Such reductions of peripheral auditory activity may influence the developing central brain during early postnatal years when the system is still highly plastic.
  
  
  OBJECTIVE
  A common cause of CHL in young children is otitis media; if chronic and/or episodic there may be a risk to speech and language development. In this clinical context we have investigated changes in neural activity patterns in the brainstem and midbrain in an animal model of CHL.
  
  
  METHODS
  In a mouse model, a 50-60 dB CHL was produced by blocking the ear canals. We quantified resting neural activity patterns in the cochlear nucleus and inferior colliculus using c-fos immuno-labelling. This experimental group was compared with normal-hearing controls and with animals with bilateral cochlear ablation.
  
  
  RESULTS
  Subjects with CHL had a statistically significant reduction in c-fos-labelled cells in the cochlear nucleus and central nucleus of the inferior colliculus compared with normal controls. This decreased c-fos expression suggests a change in resting neural activity generated at the inner hair cell synapse, leading to a reduction in activity levels in the ascending auditory pathways.
authors.affiliation: Auditory Science Laboratory, Department of Otolaryngology-HNS, Hospital for Sick Children, ON, Canada. rvh@sickkids.ca
authors.forename: Robert V
authors.initials: RV
authors.lastname: Harrison
authors.forename: Jaina
authors.initials: J
authors.lastname: Negandhi
mesh_terms: D000818:Animals; D017626:Cochlear Nucleus / Q000503:physiopathology*; D016057:Evoked Potentials, Auditory, Brain Stem; D016762:Genes, fos; D006314:Hearing Loss, Conductive / Q000503:physiopathology*; D007245:Inferior Colliculi / Q000503:physiopathology*; D051379:Mice; D008808:Mice, Inbred CBA