title: [First death case of serotonin syndrome in Japan induced by fluvoxamine and tandospirone].
abstract: We experienced the first death case of the serotonin syndrome in Japan caused by fluvoxamine and tandospirone. A 15-year-old man was transported to our hospital for shock, muscle hypertonia and hyperthermia after cardiopulmonary arrest. His serum concentrations of fluvoxamine and tandospirone were 3,554 ng/mL and 698 ng/mL respectively after 24 hours from oral intake. He was dead in spite of intensive treatments. The progress of the serotonin syndrome is usually rapid. So, it should be monitored appropriately a patient with serotonin syndrome. If he has hyperthermia, immediate paralysis should be induced. We should aware of the serotonin syndrome a case of overdose on a serotonergic agent.
authors.affiliation: Department of Critical Care Medicine, University of Fukui Hospital.
authors.forename: Takahisa
authors.initials: T
authors.lastname: Kawano
authors.forename: Takayuki
authors.initials: T
authors.lastname: Kosuge
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Takagi
authors.forename: Akira
authors.initials: A
authors.lastname: Shimoyama
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Harunari
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Tahara
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Suzuki
mesh_terms: D000293:Adolescent; D014151:Anti-Anxiety Agents / Q000009:adverse effects* / Q000097:blood; D062787:Drug Overdose; D017809:Fatal Outcome; D005334:Fever / Q000139:chemically induced*; D016666:Fluvoxamine / Q000009:adverse effects* / Q000097:blood; D006323:Heart Arrest / Q000139:chemically induced; D006801:Humans; D054833:Isoindoles / Q000009:adverse effects* / Q000097:blood; D007564:Japan; D008297:Male; D009122:Muscle Hypertonia / Q000139:chemically induced*; D010879:Piperazines / Q000009:adverse effects* / Q000097:blood; D011743:Pyrimidines / Q000009:adverse effects* / Q000097:blood; D017366:Serotonin Receptor Agonists / Q000009:adverse effects* / Q000097:blood; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects* / Q000097:blood; D012720:Severity of Illness Index; D012769:Shock / Q000139:chemically induced; D013577:Syndrome
chemical_list: D014151:Anti-Anxiety Agents; D016666:Fluvoxamine; D054833:Isoindoles; D010879:Piperazines; D011743:Pyrimidines; D017366:Serotonin Receptor Agonists; D017367:Selective Serotonin Reuptake Inhibitors; C055267:tandospirone