title: [Enzymatic activity of thymidine kinase of herpes simlex virus strain resistant to H-phosphonates of Acv].
abstract: Cloned laboratory mutants of herpes simplex virus type I resistant to acycloguanosine H-phosphonate have been investigated. For all clones were shown that mutations resulted to increasing of sensitivity to acting of sidofovir. Thymidine kinase of mutant viruses partially preserves the ability to phosphorilate thymidine, but loses the ability to phosphorilate BVDU.
authors.forename: A A
authors.initials: AA
authors.lastname: Gus'kova
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Skoblov
authors.forename: V L
authors.initials: VL
authors.lastname: Andronova
authors.forename: G A
authors.initials: GA
authors.lastname: Galegov
authors.forename: S N
authors.initials: SN
authors.lastname: Kochetkov
authors.forename: Iu S
authors.initials: IuS
authors.lastname: Skoblov
mesh_terms: D000212:Acyclovir / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D004259:DNA-Directed DNA Polymerase / Q000235:genetics / Q000378:metabolism*; D024882:Drug Resistance, Viral / Q000187:drug effects*; D018259:Herpesvirus 1, Human / Q000187:drug effects* / Q000201:enzymology*; D006801:Humans; D009154:Mutation; D063065:Organophosphonates / Q000494:pharmacology*; D013937:Thymidine Kinase / Q000737:chemistry* / Q000235:genetics; D014709:Vero Cells
chemical_list: D063065:Organophosphonates; C550134:acycloguanosine H-phosphonate; D013937:Thymidine Kinase; D004259:DNA-Directed DNA Polymerase; D000212:Acyclovir