title: Three-dimensional optical topography of brain activity in infants watching videos of human movement.
abstract: We present 3D optical topography images reconstructed from data obtained previously while infants observed videos of adults making natural movements of their eyes and hands. The optical topography probe was placed over the temporal cortex, which in adults is responsible for cognitive processing of similar stimuli. Increases in oxyhaemoglobin were measured and reconstructed using a multispectral imaging algorithm with spatially variant regularization to optimize depth discrimination. The 3D optical topography images suggest that similar brain regions are activated in infants and adults. Images were presented showing the distribution of activation in a plane parallel to the surface, as well as changes in activation with depth. The time-course of activation was followed in the pixel which demonstrated the largest change, showing that changes could be measured with high temporal resolution. These results suggest that infants a few months old have regions which are specialized for reacting to human activity, and that these subtle changes can be effectively analysed using 3D optical topography.
authors.affiliation: Department of Medical Physics and Bioengineering, University College London, Gower Street, London WC1E 6BT, UK. tcorreia@cs.ucl.ac.uk
authors.forename: Teresa
authors.initials: T
authors.lastname: Correia
authors.forename: Sarah
authors.initials: S
authors.lastname: Lloyd-Fox
authors.forename: Nick
authors.initials: N
authors.lastname: Everdell
authors.forename: Anna
authors.initials: A
authors.lastname: Blasi
authors.forename: Clare
authors.initials: C
authors.lastname: Elwell
authors.forename: Jeremy C
authors.initials: JC
authors.lastname: Hebden
authors.forename: Adam
authors.initials: A
authors.lastname: Gibson
mesh_terms: D000465:Algorithms; D001288:Attention; D001931:Brain Mapping / Q000379:methods; D015331:Cohort Studies; D003867:Depth Perception; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D007223:Infant; D009068:Movement / Q000502:physiology*; D055095:Optics and Photonics; D010108:Oxyhemoglobins / Q000378:metabolism; D013702:Temporal Lobe / Q000473:pathology; D013997:Time Factors
chemical_list: D010108:Oxyhemoglobins