title: [Screening of early lung cancer with low-dose computed tomography in high-risk populations: a meta-analysis].
abstract: OBJECTIVE
  To explore the values of low-dose computed tomography (LDCT) in the screening of high-risk populations for early lung cancer through a meta-analysis of the relevant literature.
  
  
  METHODS
  PubMed, EBSCO, Cochrane and other databases were searched with key words. And the studies were selected by the inclusion and exclusion criteria. The baseline data were collected and analyzed by statistical software.
  
  
  RESULTS
  Ten random controlled trials (RCTs) were selected. Compared to the chest X ray (CXR) screening and no screening controls, LDCT screening had an odds ratio (OR) of 3.705, 95%CI 3.527 - 3.891. And in the subgroup analysis, a higher number of stage I lung cancer was detected (OR 4.464, 95%CI 2.860 - 6.969) by LDCT. Moreover, LDCT screening showed an increased detection of adenocarcinoma in lung cancer (OR 4.652, 95%CI 2.877 - 7.522).
  
  
  CONCLUSIONS
  LDCT is superior to CXR in the early detection of lung cancer, especially stage I and adenocarcinoma.
authors.affiliation: Department of Respiratory Diseases, Nanjing General Hospital of Nanjing Military Command, Medical School of Nanjing University, Nanjing 210002, China.
authors.forename: Yan-wen
authors.initials: YW
authors.lastname: Yao
authors.forename: Dong-mei
authors.initials: DM
authors.lastname: Yuan
authors.forename: Yan-ling
authors.initials: YL
authors.lastname: Lü
authors.forename: Yu-feng
authors.initials: YF
authors.lastname: Li
authors.forename: Yong
authors.initials: Y
authors.lastname: Song
mesh_terms: D000230:Adenocarcinoma / Q000000981:diagnostic imaging*; D000077192:Adenocarcinoma of Lung; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging*; D016032:Randomized Controlled Trials as Topic; D036542:Tomography, Spiral Computed / Q000379:methods*