title: [Instructional significance of HBV-DNA load in maternal milk on breastfeeding of postpartum women infected with HBV].
abstract: OBJECTIVE
  To study the instructional significance of HBV-DNA load in maternal milk on breastfeeding of postpartum women infected with HBV.
  
  
  METHODS
  HBV-DNA levels in serum and breast milk were detected by FQ-PCR in 152 postpartum women infected with HBV, and HBV-DNA ≥ 1.0 × 10(3) U/ml was defined as HBV positive. Correlation analysis was also conducted to estimate if there were relations in HBV levels in serum and breast milk.
  
  
  RESULTS
  HBV-DNA positive rate were 50.66% (77/152) and 36.18% (55/152) in serum and breast milk, respectively. When HBeAg was positive, HBV-DNA positive rate were 95.38% (62/65) and 76.92% (50/65) in serum and breast milk; however when HBeAg was negative, HBV-DNA positive rate were 17.24% (15/87) and 5.75% (5/87) in serum and breast milk. When the concentration of HBV-DNA was 3-4 lg U/ml in serum, HBV-DNA positive rate was 20.00% (5/25) in breast milk; However, when the concentration of HBV-DNA was higher than 5 lg U/ml in serum, HBV-DNA positive rate was 96.15% (50/52) in breast milk.
  
  
  CONCLUSIONS
  The HBV-DNA level in breast milk in postpartum women infected with HBV increased with the HBV-DNA levels in serum. Breastfeeding should be avoided when the concentration of HBV-DNA is higher than 1.0 × 10(3) U/ml in milk.
authors.affiliation: Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, China.
authors.forename: Jia-ying
authors.initials: JY
authors.lastname: He
authors.forename: Ying-hua
authors.initials: YH
authors.lastname: Zhang
authors.forename: Yong-le
authors.initials: YL
authors.lastname: Zhang
authors.forename: He-feng
authors.initials: HF
authors.lastname: Huang
mesh_terms: D000328:Adult; D001942:Breast Feeding; D004279:DNA, Viral / Q000302:isolation & purification*; D005260:Female; D006509:Hepatitis B / Q000517:prevention & control / Q000635:transmission; D006513:Hepatitis B e Antigens / Q000097:blood; D006515:Hepatitis B virus; D006801:Humans; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control; D008895:Milk, Human / Q000821:virology*; D019562:Viral Load; D055815:Young Adult
chemical_list: D004279:DNA, Viral; D006513:Hepatitis B e Antigens