title: Validity of eight integrated healthcare delivery organizations' administrative clinical data to capture breast cancer chemotherapy exposure.
abstract: BACKGROUND
  Cancer Research Network (CRN) sites use administrative data to populate their Virtual Data Warehouse (VDW). However, information on VDW chemotherapy data validity is limited. The purpose of this study was to assess the validity of VDW chemotherapy data.
  
  
  METHODS
  This was a retrospective cohort study of women ≥18 years with incident, invasive breast cancer diagnosed between January 1999 and December 2007. Pharmacy and procedure chemotherapy data were extracted from each site's VDW. Random samples of 50 patients stratified on trastuzumab, anthracyclines, and no chemotherapy exposure was selected from each site for detailed chart abstraction. Weighted sensitivities and specificities of VDW compared with abstracted data were calculated. Cumulative doses calculated from VDW data were compared with doses obtained from the medical chart review.
  
  
  RESULTS
  The cohort included 13,497 patients with 6,456 (48%) chart review eligible. Patients in the sample (N = 400) had a mean age of 65 years. Trastuzumab, anthracycline, and other chemotherapy weighted sensitivities were 95%, 97%, and 100%, respectively; specificities were 99%, 99%, and 93%, respectively; positive predictive values were 96%, 99%, and 55%, respectively; and negative predictive values were 99%, 96%, and 100%. Trastuzumab and anthracyclines VDW mean doses were 873 and 386 mg, respectively, whereas abstracted mean doses were 1,734 and 369 mgs, respectively (R(2) = 0.14, P < 0.01 and R(2) = 0.05, P = 0.03, respectively).
  
  
  CONCLUSIONS
  Sensitivities and specificities for CRN chemotherapy VDW data were high and dosages were correlated with chart information.
  
  
  CONCLUSIONS
  The findings support the use of CRN data in evaluating chemotherapy exposures and related outcomes.
authors.affiliation: Pharmacy Department, Kaiser Permanente Colorado, 16601 E. Centretech Pkwy., Aurora, CO 80011, USA. tom.delate@kp.org
authors.forename: Thomas
authors.initials: T
authors.lastname: Delate
authors.forename: Erin J Aiello
authors.initials: EJ
authors.lastname: Bowles
authors.forename: Roy
authors.initials: R
authors.lastname: Pardee
authors.forename: Robert D
authors.initials: RD
authors.lastname: Wellman
authors.forename: Laurel A
authors.initials: LA
authors.lastname: Habel
authors.forename: Marianne Ulcickas
authors.initials: MU
authors.lastname: Yood
authors.forename: Larissa
authors.initials: L
authors.lastname: Nekhlyudov
authors.forename: Katrina A
authors.initials: KA
authors.lastname: Goddard
authors.forename: Robert L
authors.initials: RL
authors.lastname: Davis
authors.forename: Catherine A
authors.initials: CA
authors.lastname: McCarty
authors.forename: Adedayo A
authors.initials: AA
authors.lastname: Onitilo
authors.forename: Heather Spencer
authors.initials: HS
authors.lastname: Feigelson
authors.forename: Jared
authors.initials: J
authors.lastname: Freml
authors.forename: Edward
authors.initials: E
authors.lastname: Wagner
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy*; D017024:Chemotherapy, Adjuvant; D003625:Data Collection; D016208:Databases, Factual; D003695:Delivery of Health Care / Q000458:organization & administration*; D005260:Female; D006302:Health Services Research; D006801:Humans; D008875:Middle Aged; D011379:Prognosis; D012372:ROC Curve; D012189:Retrospective Studies