title: Ethnobotany, chemistry, and biological activities of the genus Tithonia (Asteraceae).
abstract: The genus Tithonia is an important source of diverse natural products, particularly sesquiterpene lactones, diterpenes, and flavonoids. The collected information in this review attempts to summarize the recent developments in the ethnobotany, biological activities, and secondary metabolite chemistry of this genus. More than 100 structures of natural products from Tithonia are reported in this review. The species that has been most investigated in this genus is T. diversifolia, from which ca. 150 compounds were isolated. Biological studies are described to evaluate the anti-inflammatory, analgesic, antimalarial, antiviral, antidiabetic, antidiarrhoeal, antimicrobial, antispasmodic, vasorelaxant, cancer-chemopreventive, cytotoxic, toxicological, bioinsecticide, and repellent activities. A few of these studies have been carried out with isolated compounds from Tithonia species, but the majority has been conducted with different extracts. The relationship between the biological activity and the toxicity of compounds isolated from the plants of this genus as well as T. diversifolia extracts still remains unclear, and mechanisms of action remain to be determined.
authors.affiliation: Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo (USP), Av. do Café s/n, 14040-903, Ribeirão Preto, SP, Brazil.
authors.forename: Daniela A
authors.initials: DA
authors.lastname: Chagas-Paula
authors.forename: Rejane B
authors.initials: RB
authors.lastname: Oliveira
authors.forename: Bruno A
authors.initials: BA
authors.lastname: Rocha
authors.forename: Fernando B
authors.initials: FB
authors.lastname: Da Costa
mesh_terms: D000818:Animals; D019659:Asteraceae / Q000737:chemistry*; D001688:Biological Products / Q000494:pharmacology*; D019448:Ethnobotany; D006801:Humans; D010936:Plant Extracts / Q000494:pharmacology*
chemical_list: D001688:Biological Products; D010936:Plant Extracts