title: Increased relative risk of lung cancer in 2,904 patients with saccular intracranial aneurysm disease in eastern Finland.
abstract: OBJECTIVE
  To analyze the long-term incidence of cancer after the first diagnosis of saccular intracranial aneurysm (sIA) disease.
  
  
  METHODS
  The Neurosurgery Department of the Kuopio University Hospital (KUH) solely serves a defined Eastern Finnish population. The Kuopio sIA database contains 2,904 consecutive sIA cases from 1980 to 2007, 618 unruptured (170 familial and 448 sporadic) and 2,286 ruptured aneurysmal subarachnoid hemorrhage (aSAH) cases (308 familial and 1,978 sporadic). They were followed for the incidence of cancer (Finnish Cancer Registry) until death (n = 1,176) or until December 31, 2008, giving a total of 26,844 person-years. Their standardized incidence ratios (SIRs) of different cancers were calculated as compared to the corresponding KUH population (year of follow-up, gender, age).
  
  
  RESULTS
  Lung cancer after the first sIA diagnosis occurred in 30 of the 1,340 male patients [SIR = 2.0; 95% confidence interval (CI) = 1.4-2.9], and in 10 of the 1,564 female patients (SIR = 2.6; 95% CI = 1.2-4.7). Poisson regression analysis identified male gender and increasing diameter of the ruptured sIA as independent risk factors for lung cancer, while familial sIA disease, age at aSAH, site of ruptured sIA, or the presence of associated unruptured sIAs had no significant effect.
  
  
  CONCLUSIONS
  Carriers of the sIA disease have an increased risk of developing lung cancer. Their long-term smoking habits after the sIA diagnosis should be elucidated for preventive purposes.
authors.affiliation: Neurosurgery of NeuroCenter, Kuopio University Hospital, Kuopio, Finland.
authors.forename: Terhi
authors.initials: T
authors.lastname: Huttunen
authors.forename: Annamaija
authors.initials: A
authors.lastname: Riihinen
authors.forename: Eero
authors.initials: E
authors.lastname: Pukkala
authors.forename: Mikael
authors.initials: M
authors.lastname: von und zu Fraunberg
authors.forename: Timo
authors.initials: T
authors.lastname: Koivisto
authors.forename: Antti
authors.initials: A
authors.lastname: Ronkainen
authors.forename: Jaakko
authors.initials: J
authors.lastname: Rinne
authors.forename: Juha
authors.initials: J
authors.lastname: Hernesniemi
authors.forename: Risto
authors.initials: R
authors.lastname: Sankila
authors.forename: Juha E
authors.initials: JE
authors.lastname: Jääskeläinen
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005387:Finland / Q000453:epidemiology; D006801:Humans; D002532:Intracranial Aneurysm / Q000150:complications* / Q000453:epidemiology*; D008113:Liver Neoplasms / Q000150:complications / Q000453:epidemiology; D008175:Lung Neoplasms / Q000150:complications* / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications / Q000453:epidemiology; D010190:Pancreatic Neoplasms / Q000150:complications / Q000453:epidemiology; D012306:Risk; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects*