title: On the mode of action ofClostridium difficile toxin A: anin vitro study.
abstract: C. difficile toxin A causes the rounding up and the formation of surface blebs in normal rat intestinal crypt cells (IEC-6). These phenomena, together with the inhibition of DNA synthesis and the cell lysis, could be the mechanisms leading the toxin-treated cells to death.
authors.affiliation: Lab. Ultrastrutture, Istituto Superiore di Sanita', Viale Regina Elena 299, 00161, Roma, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Fiorentini
authors.forename: G
authors.initials: G
authors.lastname: Donelli
authors.forename: P
authors.initials: P
authors.lastname: Nicotera
authors.forename: P
authors.initials: P
authors.lastname: Mastrantonio
authors.forename: M
authors.initials: M
authors.lastname: Thelestam