title: Cirrhosis due to chronic hepatitis E infection in a child post-bone marrow transplant.
abstract: Chronic hepatitis E virus (HEV) infection occurs in immunosuppressed adults. We detected HEV ribonucleic acid in serum of an adolescent patient who had undergone bone marrow transplantation and subsequently presented with persistently increased aminotransferases and histologic chronic hepatitis, and eventually developed cirrhosis. Phylogenetic analysis revealed these HEV strains were similar to swine genotype 3a, suggesting a possible zoonosis.
authors.affiliation: Department of Pediatrics, Université de Montréal, Quebec, Canada. ugur.halac@umontreal.ca
authors.forename: Ugur
authors.initials: U
authors.lastname: Halac
authors.forename: Kathie
authors.initials: K
authors.lastname: Béland
authors.forename: Pascal
authors.initials: P
authors.lastname: Lapierre
authors.forename: Natacha
authors.initials: N
authors.lastname: Patey
authors.forename: Pierre
authors.initials: P
authors.lastname: Ward
authors.forename: Julie
authors.initials: J
authors.lastname: Brassard
authors.forename: Alain
authors.initials: A
authors.lastname: Houde
authors.forename: Fernando
authors.initials: F
authors.lastname: Alvarez
mesh_terms: D000293:Adolescent; D000998:Antiviral Agents / Q000627:therapeutic use; D001707:Biopsy, Needle; D016026:Bone Marrow Transplantation / Q000009:adverse effects* / Q000276:immunology; D002908:Chronic Disease; D018450:Disease Progression; D005500:Follow-Up Studies; D016751:Hepatitis E / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D016752:Hepatitis E virus / Q000187:drug effects / Q000302:isolation & purification; D006801:Humans; D016867:Immunocompromised Host; D007150:Immunohistochemistry; D008103:Liver Cirrhosis / Q000473:pathology / Q000821:virology*; D008111:Liver Function Tests; D008297:Male; D011183:Postoperative Complications / Q000175:diagnosis / Q000628:therapy; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis / Q000601:surgery*; D018570:Risk Assessment; D012720:Severity of Illness Index; D000637:Transaminases / Q000378:metabolism
chemical_list: D000998:Antiviral Agents; D000637:Transaminases