title: Emergence of resistance to fluoroquinolones and third-generation cephalosporins in Shigella flexneri subserotype 1c isolates from China.
abstract: We report here on the first identification of Shigella flexneri subserotype 1c in China. We also report the emergence of resistance to ciprofloxacin and third-generation cephalosporins in this subserotype 1c for the first time. Isolates of seven strains circulating in China yielded three new sequence types and seven pulsed-field gel electrophoresis patterns, thus demonstrating the existence of high genetic diversity within the isolates. Overall, the seven isolates showed reduced susceptibility to ciprofloxacin; one isolate was ciprofloxacin resistant, whilst another developed resistance to ciprofloxacin, norfloxacin, cefotaxime and ceftriaxone.
authors.affiliation: Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China.
authors.forename: S
authors.initials: S
authors.lastname: Qiu
authors.forename: X
authors.initials: X
authors.lastname: Xu
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.forename: G
authors.initials: G
authors.lastname: Yang
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
authors.forename: H
authors.initials: H
authors.lastname: Wang
authors.forename: L
authors.initials: L
authors.lastname: Zhang
authors.forename: N
authors.initials: N
authors.lastname: Liu
authors.forename: C
authors.initials: C
authors.lastname: Chen
authors.forename: W
authors.initials: W
authors.lastname: Liu
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.forename: W
authors.initials: W
authors.lastname: Su
authors.forename: L
authors.initials: L
authors.lastname: Jia
authors.forename: L
authors.initials: L
authors.lastname: Wang
authors.forename: H
authors.initials: H
authors.lastname: Jin
authors.forename: P
authors.initials: P
authors.lastname: Keim
authors.forename: Z
authors.initials: Z
authors.lastname: Yuan
authors.forename: L
authors.initials: L
authors.lastname: Huang
authors.forename: H
authors.initials: H
authors.lastname: Song
mesh_terms: D002511:Cephalosporins / Q000494:pharmacology*; D002681:China / Q000453:epidemiology; D021821:Communicable Diseases, Emerging / Q000188:drug therapy / Q000382:microbiology; D003967:Diarrhea / Q000382:microbiology; D024901:Drug Resistance, Multiple, Bacterial; D004405:Dysentery, Bacillary / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology; D016521:Electrophoresis, Gel, Pulsed-Field; D005243:Feces / Q000382:microbiology; D024841:Fluoroquinolones / Q000494:pharmacology*; D014644:Genetic Variation; D006801:Humans; D008826:Microbial Sensitivity Tests; D058885:Multilocus Sequence Typing; D009268:Nalidixic Acid / Q000494:pharmacology; D012703:Serotyping; D012763:Shigella flexneri / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification* / Q000472:pathogenicity
chemical_list: D002511:Cephalosporins; D024841:Fluoroquinolones; D009268:Nalidixic Acid