title: Novel microwave synthesis of amorphous calcium phosphate nanospheres.
abstract: Amorphous calcium phosphate (ACP) is an important precursor phase in tissue mineralization. It shows high solubility and excellent remineralization ability. Commercially viable techniques for producing ACP are high-cost/low-efficiency process. This article describes a novel microwave (MW)-assisted ACP synthesis route as an alternative to current ACP synthesis methods. An important feature of the process is the use of supersaturated biomimetic fluids (SBFs), which are based on Kokubo-like simulated body fluids. However, our present compositions are substantially different in that they no longer simulate the body fluid compositions. The effects of solution composition and processing parameters were studied. The mechanism of ACP synthesis under MW irradiation process is also discussed. The as-synthesized ACP nanospheres were characterized and showed good reactivity and biocompatibility. These as-synthesized nanoparticles can be potential candidates for biomedical applications and remineralization mechanism study.
authors.affiliation: Department of Bioengineering, University of Toledo, Toledo, Ohio, USA. huan.zhou@rockets.utoledo.edu
authors.forename: Huan
authors.initials: H
authors.lastname: Zhou
authors.forename: Sarit
authors.initials: S
authors.lastname: Bhaduri
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D032701:Biomimetics; D001826:Body Fluids / Q000737:chemistry; D002130:Calcium Phosphates / Q000737:chemistry*; D002478:Cells, Cultured; D003470:Culture Media / Q000378:metabolism; D008422:Materials Testing; D051379:Mice; D008855:Microscopy, Electron, Scanning / Q000379:methods; D008872:Microwaves; D053758:Nanoparticles / Q000737:chemistry; D054118:Nanospheres / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods; D010006:Osteoblasts / Q000166:cytology; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D002130:Calcium Phosphates; D003470:Culture Media; C519480:amorphous calcium phosphate