title: Molecular biology of Philadelphia chromosome in chronic granulocytic leukaemia and acute lymphoblastic leukaemia.
abstract: In classical t(9;22) translocation, as observed in chronic granulocytic leukemia (CGL), a hybrid DNA unit is produced, including a rearranged PHL gene, previously known as bcr (breakpoint cluster region) plus the translocated c-abl gene from chromosome 9: a hybrid bcr-abl protein, p210 is formed, with increased tyrosine kinase activity. Such DNA rearrangement, with a p210 protein synthesis, is also found in cases of Philadelphia-positive acute lymphoblastic leukemia (ALL), but in apparently similar cases the bcr gene is not rearranged, and a novel p190 abl-related protein can be found; c-abl rearrangement has also been observed.It is thus established that correlations between cytogenetic and molecular events can be found in CGL and ALL, as in other haemopoietic malignancies: translocation and possible rearrangement of the c-abl oncogene seem of particular importance in this case.
authors.affiliation: Division of Haematology, United Medical Schools of Guy's, St Thomas' Campus, SE1 7EH, London, UK.
authors.forename: S
authors.initials: S
authors.lastname: Eridani
authors.forename: L M
authors.initials: LM
authors.lastname: Wiedemann
authors.forename: L C
authors.initials: LC
authors.lastname: Chan
authors.forename: R G
authors.initials: RG
authors.lastname: Dalton
authors.forename: K K
authors.initials: KK
authors.lastname: Karhi