title: Meta-analysis of navigation vs conventional total knee arthroplasty.
abstract: Navigated total knee arthroplasty (TKA) is promoted as a means to improve limb and prosthesis alignment. This study involved a systematic review and meta-analysis for all randomized controlled trials in the literature from 1986 to 2009 comparing alignment outcomes between navigated and conventional TKA. Alignment outcomes were pooled using a random-effects model, and heterogeneity was explored. Twenty-three randomized controlled trials were identified comparing navigated vs conventional TKA involving 2541 patients. Patients who underwent navigated TKA had a significantly lower risk of implant malalignment at more than 3° as well as more than 2°. In addition, the risk of malalignment was reduced for the coronal plane tibial and femoral components as well as femoral and tibial slope. This meta-analysis demonstrates that navigated TKA provides significant improvement in prosthesis alignment.
authors.affiliation: Department of Orthopaedic Surgery, McMaster University, Hamilton, Ontario, Canada.
authors.forename: Bandar M
authors.initials: BM
authors.lastname: Hetaimish
authors.forename: M Moin
authors.initials: MM
authors.lastname: Khan
authors.forename: Nicole
authors.initials: N
authors.lastname: Simunovic
authors.forename: Hatem H
authors.initials: HH
authors.lastname: Al-Harbi
authors.forename: Mohit
authors.initials: M
authors.lastname: Bhandari
authors.forename: Paul K
authors.initials: PK
authors.lastname: Zalzal
mesh_terms: D019645:Arthroplasty, Replacement, Knee / Q000295:instrumentation / Q000379:methods*; D001696:Biomechanical Phenomena; D017760:Bone Malalignment / Q000453:epidemiology / Q000517:prevention & control*; D006801:Humans; D007719:Knee Joint / Q000502:physiology; D007720:Knee Prosthesis / Q000009:adverse effects*; D012307:Risk Factors; D025321:Surgery, Computer-Assisted / Q000379:methods*