title: Cyclic dipeptides exhibit potency for scavenging radicals.
abstract: Twenty kinds of cyclic dipeptides containing l-leucine were synthesized, and their antioxidant activity against ·OH and O(2)(·-) was investigated. Compounds possessing polar amino acid residues, such as Asp, Cys, Glu, Lys, Pro, Ser, and Trp, exhibited higher antioxidant activity against ·OH than vitamin E. However, only cyclo(l-Cys-l-Leu) scavenged O(2)(·-).
authors.affiliation: Faculty of Pharmacy, Meijo University, 150 Yagotoyama, Tempaku, Nagoya 468-8503, Japan.
authors.forename: Tadashi
authors.initials: T
authors.lastname: Furukawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Akutagawa
authors.forename: Hitomi
authors.initials: H
authors.lastname: Funatani
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Uchida
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Hotta
authors.forename: Masatake
authors.initials: M
authors.lastname: Niwa
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Takaya
mesh_terms: D000595:Amino Acid Sequence; D004151:Dipeptides / Q000737:chemistry* / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000737:chemistry* / Q000494:pharmacology*; D017665:Hydroxyl Radical / Q000378:metabolism; D007930:Leucine / Q000737:chemistry / Q000494:pharmacology; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000494:pharmacology*; D026082:Singlet Oxygen / Q000378:metabolism
chemical_list: D004151:Dipeptides; D016166:Free Radical Scavengers; D010456:Peptides, Cyclic; D026082:Singlet Oxygen; D017665:Hydroxyl Radical; D007930:Leucine