title: Structure and function of Mycobacterium tuberculosis meso-diaminopimelic acid (DAP) biosynthetic enzymes.
abstract: Because of an increased emergence of resistance to current antitubercular drugs, there is a need for new antitubercular agents directed against novel targets. Diaminopimelic acid (DAP) biosynthetic enzymes are unique to bacteria and are absent in mammals and provide a rich source of essential targets for antitubercular chemotherapy. Herein, we review the structure and function of the mycobacterial DAP biosynthetic enzymes.
authors.affiliation: School of Biosciences, University of Birmingham, Birmingham, UK.
authors.forename: Veeraraghavan
authors.initials: V
authors.lastname: Usha
authors.forename: Adrian J
authors.initials: AJ
authors.lastname: Lloyd
authors.forename: Andrew L
authors.initials: AL
authors.lastname: Lovering
authors.forename: Gurdyal S
authors.initials: GS
authors.lastname: Besra
mesh_terms: D001426:Bacterial Proteins / Q000737:chemistry* / Q000235:genetics*; D003960:Diaminopimelic Acid / Q000378:metabolism*; D053858:Metabolic Networks and Pathways / Q000235:genetics*; D008958:Models, Molecular; D009169:Mycobacterium tuberculosis / Q000201:enzymology* / Q000235:genetics*; D011487:Protein Conformation
chemical_list: D001426:Bacterial Proteins; D003960:Diaminopimelic Acid