title: Long-term follow up of interventional therapy of secundum atrial septal defect.
abstract: BACKGROUND
  The percutaneous transcatheter closure of secundum atrial septal defect (ASD) is increasingly a widespread alternative to surgical closure. The aim of this study was to assess long-term results of percutaneous closure of secundum-type atrial septal defect (ASDII).
  
  
  METHODS
  Between January 2001 and December 2005, 61 patients underwent a successful percutaneous closure of ASDII; including 25 male and 36 female. All were included in the patient study and were followed up to monitor by electrocardiogram and echocardiography, at intervals of 3 days, 3 months, 6 months, 1 year, 2 years, and 5 years after operation.
  
  
  RESULTS
  Three days after percutaneous transcatheter septal closure (PTSC), the right atrium diameter, right ventricular end-diastolic left-right diameter and right ventricular end-diastolic volume (RVEDV) decreased significantly (P < 0.05). Right ventricular end-diastolic anteroposterior diameter (RVEDD), right ventricular end-systolic volume (RVESV) and right ventricular ejection fraction (RVEF) also decreased (P < 0.01). During the period from 3 to 6 months, the size of the right atrium and right ventricle returned to normal range. Three days after PTSC, the left ventricular end-diastolic diameter (LVEDD), left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV), left ventricular-systolic volume (LVSV) and left ventricular ejection fraction (LVEF) were significantly increased (P < 0.05). At 1 year, the size of the left atrium, left ventricle and left cardiac function returned to normal range (P < 0.01). There were no deaths or significant complications during the study. At five year follow-up, all defects were completely closed and remained closed thereafter.
  
  
  CONCLUSIONS
  Transcatheter closure of ASDII effectively eliminated the abnormal shunt and, subsequently improved the dimensions of each chamber and cardiac function.
authors.affiliation: Department of Cardiology, Zhengzhou Cardiovascular Hospital, Zhengzhou, Henan 450016, China. yiqiangyuan@hotmail.com
authors.forename: Yi-Qiang
authors.initials: YQ
authors.lastname: Yuan
authors.forename: Qiong
authors.initials: Q
authors.lastname: Huang
authors.forename: Li
authors.initials: L
authors.lastname: Yu
authors.forename: Rui-Min
authors.initials: RM
authors.lastname: Wang
authors.forename: Yu-Jie
authors.initials: YJ
authors.lastname: Zhao
authors.forename: Ying-Xian
authors.initials: YX
authors.lastname: Guo
authors.forename: Jun-Hua
authors.initials: JH
authors.lastname: Sun
authors.forename: Si-Quan
authors.initials: SQ
authors.lastname: Niu
authors.forename: Yun
authors.initials: Y
authors.lastname: Sun
authors.forename: Xing-Ming
authors.initials: XM
authors.lastname: Yang
authors.forename: You-Lin
authors.initials: YL
authors.lastname: Mao
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006344:Heart Septal Defects, Atrial / Q000000981:diagnostic imaging / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014463:Ultrasonography; D055815:Young Adult