title: The epigenetics of brain tumors.
abstract: Glioblastoma, medulloblastoma, and ependymoma represent molecularly and clinically diverse forms of adult and pediatric brain tumors. While each tumor displays genetic, transcriptional, and cytogenetic heterogeneity, the epigenome of these tumors has only recently emerged as a major field of interest. Here, we describe advances in our understanding of the epigenetics of brain tumors, focusing on DNA methylation, histone modifications, and microRNA deregulation which contribute to the pathogenesis of these diseases.
authors.affiliation: Department of Laboratory Medicine and Pathobiology, Division of Neurosurgery, University of Toronto, Toronto, ON, Canada.
authors.forename: Adrian M
authors.initials: AM
authors.lastname: Dubuc
authors.forename: Stephen
authors.initials: S
authors.lastname: Mack
authors.forename: Alexander
authors.initials: A
authors.lastname: Unterberger
authors.forename: Paul A
authors.initials: PA
authors.lastname: Northcott
authors.forename: Michael D
authors.initials: MD
authors.lastname: Taylor
mesh_terms: D001932:Brain Neoplasms / Q000235:genetics / Q000378:metabolism*; D019175:DNA Methylation; D004806:Ependymoma / Q000235:genetics / Q000378:metabolism*; D044127:Epigenesis, Genetic; D005909:Glioblastoma / Q000235:genetics / Q000378:metabolism*; D006657:Histones / Q000378:metabolism; D006801:Humans; D008527:Medulloblastoma / Q000235:genetics / Q000378:metabolism*; D035683:MicroRNAs / Q000502:physiology
chemical_list: D006657:Histones; D035683:MicroRNAs