title: Chiral silver phosphate-catalyzed cycloisomeric kinetic resolution of α-allenic alcohols.
abstract: A kinetic resolution of α-allenic alcohols is realized through chiral silver phosphate-catalyzed cycloisomerization with high stereoselectivity (selectivity factor up to 189) and tolerance of a variety of functional groups. A mechanistic model is proposed to interpret the origin of the high stereoselectivity and broad substrate scope.
authors.affiliation: Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , 345 Lingling Road, Shanghai 200032, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Kuan
authors.initials: K
authors.lastname: Zheng
authors.forename: Ran
authors.initials: R
authors.lastname: Hong
mesh_terms: D000438:Alcohols / Q000138:chemical synthesis* / Q000737:chemistry; D000466:Alkadienes / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D007700:Kinetics; D015394:Molecular Structure; D010710:Phosphates / Q000737:chemistry*; D018030:Silver Compounds / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; D000466:Alkadienes; D010710:Phosphates; D018030:Silver Compounds; C039072:silver phosphate