title: Mizoribine for crescentic glomerulonephritis with sarcoidosis: effectiveness not only for urinalysis abnormalities but also for hilar lymph node enlargement.
abstract: Sarcoidosis is a multisystem disease related to helper T cell responses. We recently experienced the case of a 57-year-old woman with sarcoidosis complicated by crescentic glomerulonephritis with low levels of myeloperoxidase-antineutrophil cytoplasmic antibody. We herein describe the details of her clinical course and discuss the effectiveness of mizoribine, which has an immunosuppressive effect equivalent to that of mycophenolate mofetil, not only for urinalysis abnormalities but also for hilar lymph node enlargement.
authors.affiliation: Division of Cardiology, Nephrology, Pulmonology and Neurology, Department of Internal Medicine, Asahikawa Medical University, Asahikawa, Japan.
authors.forename: Maki
authors.initials: M
authors.lastname: Kabara
authors.forename: Naoki
authors.initials: N
authors.lastname: Nakagawa
authors.forename: Motoki
authors.initials: M
authors.lastname: Matsuki
authors.forename: Junko
authors.initials: J
authors.lastname: Chinda
authors.forename: Takayuki
authors.initials: T
authors.lastname: Fujino
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Hasebe
mesh_terms: D019268:Antibodies, Antineutrophil Cytoplasmic / Q000032:analysis / Q000097:blood; D004359:Drug Therapy, Combination; D005260:Female; D005921:Glomerulonephritis / Q000097:blood / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007677:Kidney Function Tests; D008198:Lymph Nodes / Q000473:pathology; D008206:Lymphatic Diseases / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D008875:Middle Aged; D009195:Peroxidase / Q000097:blood / Q000276:immunology; D011239:Prednisolone / Q000627:therapeutic use; D013902:Radiography, Thoracic; D012263:Ribonucleosides / Q000627:therapeutic use*; D012507:Sarcoidosis / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D016896:Treatment Outcome; D016482:Urinalysis
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D007166:Immunosuppressive Agents; D012263:Ribonucleosides; C010052:mizoribine; D011239:Prednisolone; D009195:Peroxidase