title: In vitro fertilization is a successful treatment in endometriosis-associated infertility.
abstract: OBJECTIVE
  To assess success rates of IVF and intracytoplasmic sperm injection in women with various stages of endometriosis.
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  Reproductive medicine unit in a university hospital.
  
  
  METHODS
  Infertile women (n = 2,245) with various stages of endometriosis or tubal factor infertility.
  
  
  METHODS
  IVF or intracytoplasmic sperm injection.
  
  
  METHODS
  Dose of FSH, number of oocytes retrieved, fertilization rate, implantation rate, pregnancy rate (PR), live birth/ongoing PR.
  
  
  RESULTS
  Women with endometriosis had similar pregnancy and live birth/ongoing PR as did women with tubal factor infertility, but the American Society for Reproductive Medicine (ASRM) stage I and II endometriosis patients had a lower fertilization rate, and stage III and IV patients required more FSH and had fewer oocytes retrieved. Splitting the stage III and IV groups into patients with and without endometriomas showed that the endometrioma group required more FSH and had a significantly lower pregnancy and live birth/ongoing PR.
  
  
  CONCLUSIONS
  With the exception of patients with endometrioma, infertile women with various stages of endometriosis have the same success rates with IVF and intracytoplasmic sperm injection as patients with tubal factor. This contrasts with the systematic review on which the European Society of Human Reproduction and Embryology bases its recommendations.
authors.affiliation: Section for Reproductive Medicine, Department of Gynaecology, Oslo University Hospital Rikshospitalet, Oslo, Norway. hans.kristian.opoien@rikshospitalet.no
authors.forename: Hans Kristian
authors.initials: HK
authors.lastname: Opøien
authors.forename: Peter
authors.initials: P
authors.lastname: Fedorcsak
authors.forename: Anne Katerine
authors.initials: AK
authors.lastname: Omland
authors.forename: Thomas
authors.initials: T
authors.lastname: Abyholm
authors.forename: Sverre
authors.initials: S
authors.lastname: Bjercke
authors.forename: Gudvor
authors.initials: G
authors.lastname: Ertzeid
authors.forename: Nan
authors.initials: N
authors.lastname: Oldereid
authors.forename: Jan Roar
authors.initials: JR
authors.lastname: Mellembakken
authors.forename: Tom
authors.initials: T
authors.lastname: Tanbo
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D016009:Chi-Square Distribution; D004624:Embryo Transfer; D004715:Endometriosis / Q000150:complications*; D005184:Fallopian Tube Diseases / Q000150:complications*; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000627:therapeutic use; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000503:physiopathology / Q000628:therapy*; D050498:Live Birth; D016015:Logistic Models; D009664:Norway; D054315:Oocyte Retrieval; D010062:Ovulation Induction; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D012720:Severity of Illness Index; D020554:Sperm Injections, Intracytoplasmic; D016896:Treatment Outcome
chemical_list: D005300:Fertility Agents, Female; D005640:Follicle Stimulating Hormone