title: Synthesis of new α aminophosphonate system bearing Indazole moiety and their biological activity.
abstract: We are reporting herein for the first time the synthesis of α-aminophosphonates containing Indazole moiety in two steps. In the first step, imines of substituted N-benzylidene-1-methyl-1H-indazole-3-carbohydrazide are synthesized and in the next step it has converted to α-aminophosphonates using chlorotrimethylsilane (TMSCl) and triethyl phosphite. Some of the synthesized derivatives are evaluated for antibacterial activity against different bacterial strains.
authors.affiliation: Post Graduate and Research Centre, Department of Chemistry, Maulana Azad College, Rauza Bagh, Aurangabad 431 001, Maharashtra, India.
authors.forename: Nasir ali Shafakat
authors.initials: Na
authors.lastname: Ali
authors.forename: Shaikh
authors.initials: S
authors.lastname: Zakir
authors.forename: Muqtadir
authors.initials: M
authors.lastname: Patel
authors.forename: Mazahar
authors.initials: M
authors.lastname: Farooqui
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D007191:Indazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D015394:Molecular Structure; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D007191:Indazoles; D063065:Organophosphonates; C573620:diethyl (2-(1-methyl-1H-indazole-3-carbonyl)hydrazinyl)(4-(trifluoro)phenyl)methylphosphonate