title: Perinatal collagen turnover markers in intrauterine growth restriction.
abstract: OBJECTIVE
  To investigate bone and connective tissue collagen turnover in intrauterine growth restricted (IUGR) pregnancies, by determining circulating markers of type I collagen synthesis (carboxy-terminal propeptide of type I procollagen [PICP], representing bone formation) and degradation (cross-linked telopeptide of type I collagen [ICTP], representing bone resorption) as well as type III collagen synthesis (N-terminal propeptide of type-III procollagen [PIIINP], reflecting growth and tissue maturity).
  
  
  METHODS
  Plasma PICP, ICTP and PIIINP concentrations were measured in 40 mothers and their 20 asymmetric IUGR and 20 appropriate for gestational age (AGA) full-term fetuses and neonates on postnatal day 1-(N1) and 4-(N4).
  
  
  RESULTS
  Fetal PICP, fetal and N4 ICTP, as well as fetal, N1 and N4 PIIINP concentrations were higher in the IUGR group (p ≤ 0.038, in all cases). In both groups, maternal PICP, ICTP and PIIINP concentrations were lower than fetal, N1 and N4 ones (p<0.001, in each case).
  
  
  CONCLUSIONS
  Type I collagen turnover is enhanced in IUGR than AGA fetuses/neonates. Similarly, fetal/neonatal PIIINP concentrations are elevated in IUGR, probably due to stress, responsible for induction of tissue maturation, and/or to impaired excretory renal function, leading to reduced protein clearance. Fetal/neonatal PICP, ICTP and PIIINP concentrations are higher than maternal concentrations, possibly reflecting increased skeletal growth and collagen turnover in the former.
authors.affiliation: Neonatal Division, Second Department of Obstetrics and Gynecology, Athens University Medical School, Athens, Greece.
authors.forename: Demetrios
authors.initials: D
authors.lastname: Gourgiotis
authors.forename: Despina D
authors.initials: DD
authors.lastname: Briana
authors.forename: Anestis
authors.initials: A
authors.lastname: Georgiadis
authors.forename: Maria
authors.initials: M
authors.lastname: Boutsikou
authors.forename: Stavroula
authors.initials: S
authors.lastname: Baka
authors.forename: Antonios
authors.initials: A
authors.lastname: Marmarinos
authors.forename: Demetrios
authors.initials: D
authors.lastname: Hassiakos
authors.forename: Ariadne
authors.initials: A
authors.lastname: Malamitsi-Puchner
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000032:analysis / Q000097:blood / Q000378:metabolism; D016723:Bone Remodeling / Q000502:physiology; D016022:Case-Control Studies; D003094:Collagen / Q000097:blood / Q000378:metabolism*; D024042:Collagen Type I / Q000097:blood / Q000378:metabolism; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood / Q000175:diagnosis / Q000378:metabolism*; D005333:Fetus / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn / Q000097:blood / Q000378:metabolism; D008297:Male; D036801:Parturition / Q000097:blood / Q000378:metabolism*; D010446:Peptide Fragments / Q000097:blood / Q000378:metabolism; D010455:Peptides / Q000097:blood / Q000378:metabolism; D011247:Pregnancy; D011347:Procollagen / Q000097:blood / Q000378:metabolism
chemical_list: D015415:Biomarkers; D024042:Collagen Type I; D010446:Peptide Fragments; D010455:Peptides; D011347:Procollagen; C052929:collagen type I trimeric cross-linked peptide; C041876:procollagen Type III-N-terminal peptide; C042813:procollagen type I carboxy terminal peptide; D003094:Collagen