title: Hemispheric asymmetry in non-linear interdependence of EEG in post-traumatic stress disorder.
abstract: OBJECTIVE
  While volumetric and metabolic imaging on post-traumatic stress disorder (PTSD) patients has been intensively performed, few studies using electroencephalograms (EEG) have been done as yet. The aim of the present study was to investigate abnormalities in functional connectivity of cortical networks in PTSD.
  
  
  METHODS
  Non-linear interdependence (NI), a measure of bidirectional, non-linear information transmission between two time series, was used. Resting EEG were recorded for 18 PTSD patients and 18 sex-matched healthy subjects on 16 channels with their eyes closed.
  
  
  RESULTS
  The NI patterns in PTSD patients were hemisphere asymmetric: an increase in NI in the fronto-parieto-temporal regions of the left hemisphere (F7, F3, T3, C3, T5 and P3) and a decrease in the fronto-parieto-occipital regions of the right hemisphere (F4, C4, P4 and O2). The non-linearity of NI in EEG, estimated from the surrogate data method, exhibited an increase in the PTSD patients as compared with that of healthy subjects, particularly in the left hemispheric cortex.
  
  
  CONCLUSIONS
  Abnormal functional connectivity in PTSD can be assessed using NI, a measure of multi-channel EEG.
authors.affiliation: Department of Bio and Brain Engineering, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, Korea.
authors.forename: Jinho
authors.initials: J
authors.lastname: Kim
authors.forename: Jeong-Ho
authors.initials: JH
authors.lastname: Chae
authors.forename: Hee-Kyoung
authors.initials: HK
authors.lastname: Ko
authors.forename: Charles-Francois Vincent
authors.initials: CF
authors.lastname: Latchoumane
authors.forename: Aveek
authors.initials: A
authors.lastname: Banerjee
authors.forename: Donald J
authors.initials: DJ
authors.lastname: Mandell
authors.forename: Christina W
authors.initials: CW
authors.lastname: Hoven
authors.forename: Jaeseung
authors.initials: J
authors.lastname: Jeong
mesh_terms: D000328:Adult; D001921:Brain / Q000503:physiopathology*; D004569:Electroencephalography; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009415:Nerve Net / Q000503:physiopathology*; D013313:Stress Disorders, Post-Traumatic / Q000503:physiopathology*