title: Co-sensitivity to the incentive properties of palatable food and cocaine in rats; implications for co-morbid addictions.
abstract: Several lines of evidence suggest that there may be a shared vulnerability to acquire behaviors motivated by strong incentive stimuli. Non-food restricted male Sprague-Dawley rats (n = 78) underwent place conditioning with Oreos, and were subsequently tested on cocaine self-administration (SA) on fixed and progressive ratios, as well as extinction and reinstatement by cocaine primes and by consumption of Oreos. Although there was a group preference for the Oreo-paired compartment, at the individual level some rats (69%) displayed a preference and others did not. In cocaine SA, 'preference' rats achieved higher break points on a progressive ratio, and displayed greater responding during extinction and cocaine-induced reinstatement. Within the context of this study, Oreo-cocaine cross-reinstatement was not observed. In a control study, rats (n = 29) conditioned with a less palatable food (rice cakes) also displayed individual differences in place preference, but not on subsequent cocaine tests. These findings indicate that there is a relationship between incentive learning promoted by palatable foods and by cocaine. This supports the hypothesis that co-morbid food-drug addictions may result from a shared vulnerability to acquire behaviors motivated by strong incentives.
authors.affiliation: Department of Psychology, University of Guelph, Ontario, Canada.
authors.forename: AnneMarie
authors.initials: A
authors.lastname: Levy
authors.forename: Avi
authors.initials: A
authors.lastname: Salamon
authors.forename: Mark
authors.initials: M
authors.lastname: Tucci
authors.forename: Cheryl L
authors.initials: CL
authors.lastname: Limebeer
authors.forename: Linda A
authors.initials: LA
authors.lastname: Parker
authors.forename: Francesco
authors.initials: F
authors.lastname: Leri
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D016739:Behavior, Addictive / Q000523:psychology*; D002755:Choice Behavior / Q000502:physiology; D003042:Cocaine / Q000008:administration & dosage / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000502:physiology; D004198:Disease Susceptibility; D018765:Dopamine Uptake Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D058999:Drug-Seeking Behavior / Q000502:physiology*; D005108:Extinction, Psychological / Q000502:physiology; D005518:Food Preferences / Q000502:physiology; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D009042:Motivation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012055:Reinforcement Schedule; D012646:Self Administration / Q000706:statistics & numerical data; D013997:Time Factors
chemical_list: D018765:Dopamine Uptake Inhibitors; D003042:Cocaine