title: Relevance of dopamine D(2)/neurotensin NTS1 and NMDA/neurotensin NTS1 receptor interaction in psychiatric and neurodegenerative disorders.
abstract: The existence of functional NT/dopamine interactions in the central nervous system has been extensively documented. Among others, a possible molecular mechanism underlying the NT-induced modulation of dopamine release is a direct antagonistic NTS(1)/D(2) receptor interaction. More recently, neurochemical experiments also supported the existence of a possible interaction between NT and N-methyl-d-aspartate (NMDA) receptors. In particular, it has been suggested that NT, by amplifying NMDA receptor signaling, could be involved in neurodegeneration. The present article attempts to provide a summary of current knowledge, mainly emerging from our studies, on the existence of receptor-receptor interactions between NT receptor subtype 1 (NTS1) and dopamine D(2) or NMDA receptors in the brain. Special emphasis is placed on the pre and post-synaptic neurochemical mechanisms possibly underlying the involvement of these interactions in the physiopathology of schizophrenia and acute neurodegenerative disorders.
authors.affiliation: Department of Clinical and Experimental Medicine, Pharmacology Section, Via Fossato di Mortara 17-19, 44100, Ferrara, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Tanganelli
authors.forename: T
authors.initials: T
authors.lastname: Antonelli
authors.forename: M C
authors.initials: MC
authors.lastname: Tomasini
authors.forename: S
authors.initials: S
authors.lastname: Beggiato
authors.forename: K
authors.initials: K
authors.lastname: Fuxe
authors.forename: L
authors.initials: L
authors.lastname: Ferraro
mesh_terms: D000818:Animals; D006801:Humans; D008954:Models, Biological; D019636:Neurodegenerative Diseases / Q000378:metabolism* / Q000473:pathology; D009496:Neurotensin / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D025941:Protein Interaction Mapping; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*; D018028:Receptors, Neurotensin / Q000037:antagonists & inhibitors / Q000378:metabolism*; D012559:Schizophrenia / Q000378:metabolism* / Q000473:pathology; D013329:Structure-Activity Relationship
chemical_list: D017448:Receptors, Dopamine D2; D016194:Receptors, N-Methyl-D-Aspartate; D018028:Receptors, Neurotensin; C114036:neurotensin type 1 receptor; D009496:Neurotensin