title: Evaluating distinctive features for early diagnosis of primary sclerosing cholangitis overlap syndrome in adults with autoimmune hepatitis.
abstract: OBJECTIVE
  Overlap syndromes constitute a significant proportion of autoimmune liver disease. Our aim was to describe our cohort and evaluate practical methods of correctly diagnosing autoimmune hepatitis/primary sclerosing cholangitis overlap syndrome as early as possible clinically.
  
  
  METHODS
  118 autoimmune hepatitis patients were screened for cholestatic liver function tests. 24 patients with cholestatic liver function tests were investigated for possible primary sclerosing cholangitis by clinicopathological review and magnetic resonance cholangiography. Retrospectively, potential predictors of autoimmune hepatitis/primary sclerosing cholangitis overlap syndrome were compared with a control group.
  
  
  RESULTS
  Overlap syndrome was diagnosed in twelve (50%) of 24 autoimmune hepatitis patients with recent cholestasis. The cholestatic group had a lower AST (p=0.012) and International Autoimmune Hepatitis Group (IAHG) score (p=0.102), and higher IgM (p=0.002) at disease presentation. More patients in the cholestatic group developed ulcerative colitis (p=0.138).
  
  
  CONCLUSIONS
  Identifying AIH / PSC overlap syndrome at diagnosis is often difficult. Certain clinical and biochemical features should alert the clinician. All patients with AIH, and biochemical cholestasis should be investigated with MRC.
authors.affiliation: Department of Infectious Diseases, 3rd Floor, East Wing, Royal Victoria Hospital, Grosvenor Road, BT12 6BA Belfast. michaelgarvinhunter@hotmail.com
authors.forename: Michael
authors.initials: M
authors.lastname: Hunter
authors.forename: Maurice B
authors.initials: MB
authors.lastname: Loughrey
authors.forename: Moyra
authors.initials: M
authors.lastname: Gray
authors.forename: Peter
authors.initials: P
authors.lastname: Ellis
authors.forename: Neil
authors.initials: N
authors.lastname: McDougall
authors.forename: Michael
authors.initials: M
authors.lastname: Callender
mesh_terms: D000328:Adult; D001706:Biopsy; D016022:Case-Control Studies; D049448:Cholangiopancreatography, Magnetic Resonance; D015209:Cholangitis, Sclerosing / Q000175:diagnosis*; D002779:Cholestasis / Q000175:diagnosis*; D005260:Female; D019693:Hepatitis, Autoimmune / Q000175:diagnosis*; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors; D018709:Statistics, Nonparametric; D013577:Syndrome