title: Therapeutic potential and strategies against leukocyte-platelet interaction in atherosclerosis.
abstract: Leukocyte rolling, adhesion, transmigration and activation are features of vascular inflammation leading to atherosclerosis. In particular the interaction between platelets and leukocytes is a key process for adhesion of inflammatory cells to the vascular wall. The various mechanisms of the specific platelet-leukocyte interaction may provide a powerful target to prevent initiation and/or progression of atherosclerotic lesions.
authors.affiliation: Medizinische Klinik III, Kardiologie und Kreislauferkrankungen, Eberhard Karls-Universität Tübingen, Tubingen,Germany. peter.seizer@med.uni-tuebingen.de
authors.forename: Peter
authors.initials: P
authors.lastname: Seizer
authors.forename: Andreas E
authors.initials: AE
authors.lastname: May
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000188:drug therapy / Q000503:physiopathology* / Q000517:prevention & control; D001792:Blood Platelets / Q000378:metabolism*; D002448:Cell Adhesion; D018450:Disease Progression; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000503:physiopathology; D036904:Leukocyte Rolling; D007962:Leukocytes / Q000378:metabolism*