title: Chemerin as biomarker for insulin sensitivity in males without typical characteristics of metabolic syndrome.
abstract: To allow early detection and prevention of metabolic disorders, circulating levels of adipokines involved in insulin sensitivity were compared with the hyperinsulinemic-euglycemic clamp. Twenty non-obese normo-glycaemic men (age 32.1 ± 6 years) underwent a clamp procedure. Levels of leptin, adiponectin, resistin, visfatin, omentin and chemerin levels were determined in fasting blood samples. Pearson correlation coefficients between the M-value for insulin sensitivity and fasting levels of chemerin (r = -0.63, P = 0.003) and leptin (r = -0.54, P = 0.013) performed better than conventional surrogate measures of insulin sensitivity (HOMA-IR: r = -0.45, P = 0.048; Quicki: r = 0.36, P = 0.12). However, only the relation between M-value(LBM) and chemerin remained significant when adjusting for BMI and fasting insulin levels (r = -0.559, P = 0.016). In conclusion, fasting levels of chemerin might be used as biomarker to identify insulin resistance in healthy men without typical characteristics of metabolic disorders.
authors.affiliation: Institute for Clinical Biochemistry and Pathobiochemistry, German Diabetes Center, Duesseldorf, Germany.
authors.forename: D Margriet
authors.initials: DM
authors.lastname: Ouwens
authors.forename: Marlies
authors.initials: M
authors.lastname: Bekaert
authors.forename: Bruno
authors.initials: B
authors.lastname: Lapauw
authors.forename: Yves
authors.initials: Y
authors.lastname: Van Nieuwenhove
authors.forename: Stefan
authors.initials: S
authors.lastname: Lehr
authors.forename: Sonja
authors.initials: S
authors.lastname: Hartwig
authors.forename: Patrick
authors.initials: P
authors.lastname: Calders
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Kaufman
authors.forename: Henrike
authors.initials: H
authors.lastname: Sell
authors.forename: Juergen
authors.initials: J
authors.lastname: Eckel
authors.forename: Johannes B
authors.initials: JB
authors.lastname: Ruige
mesh_terms: D054392:Adipokines / Q000097:blood; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D018925:Chemokines / Q000097:blood*; D005215:Fasting; D005947:Glucose / Q000008:administration & dosage; D015309:Glucose Clamp Technique; D006801:Humans; D007328:Insulin / Q000097:blood / Q000494:pharmacology*; D007333:Insulin Resistance; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male
chemical_list: D054392:Adipokines; D015415:Biomarkers; D001786:Blood Glucose; D018925:Chemokines; D007328:Insulin; D036341:Intercellular Signaling Peptides and Proteins; C478630:RARRES2 protein, human; D005947:Glucose