title: Imaging manifestation of conventional and contrast-enhanced ultrasonography in percutaneous microwave ablation for the treatment of uterine fibroids.
abstract: OBJECTIVE
  To evaluate the image changes and the relationship between conventional ultrasonography and contrast-enhanced ultrasound (CEUS) in the perioperative period of microwave (MW) ablation for uterine fibroids; to guide clinical ablation therapy and evaluate the efficacy of MW.
  
  
  METHODS
  Twenty-nine patients with 31 uterine fibroids were recruited in this study. All patients received conventional ultrasound as well as CEUS examination before, immediately after and 12-24 h after MW, in order to detect variations of echo and characteristics of blood supply. t-Tests were used to compare the hyperecho area on gray-scale ultrasound to immediately after ablation non-enhanced CEUS measurements, as well as to compare the immediately after ablation non-enhanced CEUS measurements to the 12-24 h after ablation measurements.
  
  
  RESULTS
  Immediately after ablation, the average hyperecho area in gray-scale was 82.20±72.32 cm3; the average non-enhancement area was 76.34±70.63 cm3 by CEUS, showing a strong correlation (r=0.997, P<0.01) to the hyperecho area in gray-scale. The average non-enhancement area measured by CEUS immediately after ablation was 90.55±74.41 cm3 and average 12-24h after ablation was 98.29±78.25 cm3; no statistically significant difference was detected between the two time points (P>0.05).
  
  
  CONCLUSIONS
  Measurements made by hyperechoic range on gray-scale ultrasonography is strongly correlated to the no enhancement area by CEUS. The hyperechoic range on gray-scale image can represent the ablated area immediately after MW.
authors.affiliation: Department of Interventional Ultrasound, Chinese PLA General Hospital, 28 Fuxing Road, Beijing 100853, China. wfbj2010@qq.com
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Zhi-Yu
authors.initials: ZY
authors.lastname: Han
authors.forename: Zhi-Gang
authors.initials: ZG
authors.lastname: Cheng
authors.forename: Hong-Yu
authors.initials: HY
authors.lastname: Zhou
authors.forename: Lei
authors.initials: L
authors.lastname: Feng
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Hu
mesh_terms: D000328:Adult; D003287:Contrast Media; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D007889:Leiomyoma / Q000000981:diagnostic imaging* / Q000601:surgery*; D008872:Microwaves / Q000627:therapeutic use*; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D025321:Surgery, Computer-Assisted / Q000379:methods; D016896:Treatment Outcome; D014463:Ultrasonography / Q000379:methods*; D014594:Uterine Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery*
chemical_list: D003287:Contrast Media