title: Rare suprasellar glioblastoma: report of two cases and review of the literature.
abstract: BACKGROUND
  The suprasellar and hypothalamic/chiasmatic regions can harbor a broad range of pathologic conditions, both neoplastic and nonneoplastic; however, malignant gliomas are extremely rare in those regions.
  
  
  METHODS
  Patient 1 was a 70 year-old man with weight loss and rapidly progressive visual impairment. A mass centered in the hypothalamus was detected on magnetic resonance (MR) imaging. The second patient, a 45 year-old woman, complained of visual symptoms and headaches. MR imaging revealed a combined intra- and suprasellar mass. In both instances, the preoperative differential diagnosis favored craniopharyngioma. Histological examination confirmed the diagnosis of glioblastoma.
  
  
  CONCLUSIONS
  We report two rare adult cases of hypothalamic/chiasmatic glioblastoma. The authors review the literature, highlighting the importance of considering this rare entity in the differential diagnosis of suprasellar and hypothalamic lesions.
authors.affiliation: Institute of Neuropathology, University Hospital Zurich, Schmelzbergstrasse 12, 8091 Zurich, Switzerland. doreen.lemm@gmx.ch
authors.forename: Doreen
authors.initials: D
authors.lastname: Lemm
authors.forename: Francine Hehn
authors.initials: FH
authors.lastname: de Oliveira
authors.forename: René-Ludwig
authors.initials: RL
authors.lastname: Bernays
authors.forename: Ralf Alfons
authors.initials: RA
authors.lastname: Kockro
authors.forename: Spyros
authors.initials: S
authors.lastname: Kollias
authors.forename: Ingeborg
authors.initials: I
authors.lastname: Fischer
authors.forename: Elisabeth J
authors.initials: EJ
authors.lastname: Rushing
mesh_terms: D000368:Aged; D015875:Anisocoria / Q000209:etiology; D015254:DNA Modification Methylases / Q000235:genetics; D045643:DNA Repair Enzymes / Q000235:genetics; D017809:Fatal Outcome; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D005909:Glioblastoma / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D006801:Humans; D007029:Hypothalamic Neoplasms / Q000473:pathology / Q000601:surgery; D007150:Immunohistochemistry; D007521:Isocitrate Dehydrogenase / Q000378:metabolism; D019394:Ki-67 Antigen / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D019635:Neurosurgical Procedures; D010291:Paresis / Q000209:etiology; D012888:Skull Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D025521:Tumor Suppressor Proteins / Q000235:genetics; D014786:Vision Disorders / Q000209:etiology
chemical_list: D005904:Glial Fibrillary Acidic Protein; D019394:Ki-67 Antigen; D025521:Tumor Suppressor Proteins; D007521:Isocitrate Dehydrogenase; C543588:IDH1 protein, human; D015254:DNA Modification Methylases; C515491:MGMT protein, human; D045643:DNA Repair Enzymes