title: [Management of adverse effects of targeted therapy toxicities in oncology].
abstract: During the past few years, medical treatments of cancer have improved thanks to the discovery of targeted therapies. These therapies are today widely used in cancer treatment. The mechanism of action of targeted therapies and the adverse effects they induce are different from the classic chemotherapies, and require a specific management. Most of these drugs are taken at home and orally, and as a consequence, general practitioners should be able to manage these side effects. The most current toxicities in general medicine are fatigue, high blood pressure, dermatologic, gastrointestinal and metabolic side effects. These effects, often moderate are frequent and diverse, and can impact the patient's quality of life and reduce treatment compliance. Management of these toxicities should then be well known by general practitioners in order to optimize care and improve patient wellness.
authors.affiliation: Centre François-Baclesse, 14000 Caen.
authors.forename: Elodie
authors.initials: E
authors.lastname: Coquan
authors.forename: Patrick
authors.initials: P
authors.lastname: Henri
authors.forename: Sixtine
authors.initials: S
authors.lastname: de Raucourt
authors.forename: Barbara
authors.initials: B
authors.lastname: Lireux
authors.forename: Eric
authors.initials: E
authors.lastname: Lamy
authors.forename: Corinne
authors.initials: C
authors.lastname: Delcambre
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Sevin
authors.forename: Caroline
authors.initials: C
authors.lastname: Dutriaux
authors.forename: Karine
authors.initials: K
authors.lastname: Bouhier-Leporrier
authors.forename: Radj
authors.initials: R
authors.lastname: Gervais
authors.forename: Florence
authors.initials: F
authors.lastname: Joly
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects; D001691:Biological Therapy / Q000009:adverse effects*; D005221:Fatigue / Q000139:chemically induced / Q000517:prevention & control; D005767:Gastrointestinal Diseases / Q000139:chemically induced / Q000517:prevention & control; D006801:Humans; D006973:Hypertension / Q000139:chemically induced / Q000517:prevention & control; D007166:Immunosuppressive Agents / Q000009:adverse effects; D008659:Metabolic Diseases / Q000139:chemically induced / Q000517:prevention & control; D058990:Molecular Targeted Therapy / Q000009:adverse effects*; D009369:Neoplasms / Q000188:drug therapy; D010349:Patient Compliance; D047428:Protein Kinase Inhibitors / Q000009:adverse effects; D011788:Quality of Life; D012871:Skin Diseases / Q000139:chemically induced / Q000517:prevention & control; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D007166:Immunosuppressive Agents; D047428:Protein Kinase Inhibitors