title: Modulating mesothelin shedding to improve therapy.
authors.forename: Ira
authors.initials: I
authors.lastname: Pastan
authors.forename: Yujian
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D051722:ADAM Proteins / Q000235:genetics; D000072198:ADAM17 Protein; D036002:ADP Ribose Transferases / Q000494:pharmacology*; D000951:Antigens, Neoplasm / Q000276:immunology / Q000378:metabolism*; D001427:Bacterial Toxins / Q000494:pharmacology*; D045744:Cell Line, Tumor; D005098:Exotoxins / Q000494:pharmacology*; D058851:GPI-Linked Proteins / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D000090204:Mesothelin; D008654:Mesothelioma / Q000188:drug therapy*; D058990:Molecular Targeted Therapy / Q000379:methods; D034622:RNA Interference; D034741:RNA, Small Interfering; D011993:Recombinant Fusion Proteins / Q000494:pharmacology*; D037521:Virulence Factors / Q000494:pharmacology*; D000097668:Pseudomonas aeruginosa Exotoxin A
chemical_list: D051722:ADAM Proteins; D000072198:ADAM17 Protein; D036002:ADP Ribose Transferases; D000951:Antigens, Neoplasm; D001427:Bacterial Toxins; D005098:Exotoxins; D058851:GPI-Linked Proteins; D000090204:Mesothelin; D034741:RNA, Small Interfering; D011993:Recombinant Fusion Proteins; D037521:Virulence Factors; D000097668:Pseudomonas aeruginosa Exotoxin A