title: Systemic scAAV9 variant mediates brain transduction in newborn rhesus macaques.
abstract: Transgenic macaques would allow to study brain function and diseases. We report that an engineered adeno-associated virus serotype 9 variant (scAAV9) injected intravenously in newborn rhesus macaques results in efficient, exclusively-neuronal and widespread transduction of the brain. The present data pave the way to large-scale genetic modelling of brain diseases in the rhesus macaque.
authors.affiliation: Univ. de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293, F-33000 Bordeaux, France.
authors.forename: Benjamin
authors.initials: B
authors.lastname: Dehay
authors.forename: Deniz
authors.initials: D
authors.lastname: Dalkara
authors.forename: Sandra
authors.initials: S
authors.lastname: Dovero
authors.forename: Qin
authors.initials: Q
authors.lastname: Li
authors.forename: Erwan
authors.initials: E
authors.lastname: Bezard
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D000831:Animals, Newborn; D001921:Brain / Q000378:metabolism*; D000229:Dependovirus / Q000235:genetics*; D005822:Genetic Vectors; D049452:Green Fluorescent Proteins / Q000235:genetics; D008253:Macaca mulatta; D014161:Transduction, Genetic
chemical_list: D049452:Green Fluorescent Proteins