title: Massive myocardial infiltration by HIV-related non-Hodgkin lymphoma:  echocardiographic aspects at diagnosis and at follow-up.
abstract: A 23-year-old male presented with severe rest dyspnoea, engorged jugular veins, ankle oedema and heart rate 140 bpm. Computed tomography (CT) scan showed a large mediastinal mass with pericardial and atrial infiltration, pulmonary artery and superior vena cava compression. HIV infection was detected. Echocardiography showed 5 × 4 cm masses both in the right and the left atria, pericardial effusion, thickening of the right and left ventricular walls and hypokinesis; after intravenous contrast medium (SonoVue), the ventricular myocardium showed an increased, granular echogenicity, as did the mediastinal mass and pericardium. Nadroparin, bisoprolol, amiodarone and (suspecting non-Hodgkin lymphoma) steroids were started. After 3 days, at echocardiogram, the thickness of the ventricular walls was reduced and ejection fraction was improved. Mediastinal biopsy disclosed a large B-cell lymphoma. After starting systemic chemotherapy (rituximab, cyclophosphamide, vincristine, doxorubicin) and highly active antiretroviral therapy (HAART), 11 days after admission the patient was in New York Heart Association (NYHA) class 1-2, with normal jugular veins and no oedema. The echocardiogram showed no more pericardial effusion, atrial masses reduced by 50%, normal interventricular septum thickness and ejection fraction. In August 2010, after six cycles of chemotherapy followed by radiotherapy, the patient was in complete remission. This case shows both the echocardiographic findings typical of neoplastic infiltration of the myocardium and the rapid improvement observed within a few days after chemotherapy. In the HAART era patients with HIV-related lymphoma and even massive involvement of the heart may receive aggressive treatment with curative intent. Echocardiography is useful in early assessment of the response to therapy.
authors.affiliation: Cardiology Unit, National Cancer Institute, Via Gallini 2, Aviano (PN), Italy. clestuzzi@cro.it
authors.forename: Chiara
authors.initials: C
authors.lastname: Lestuzzi
authors.forename: Michele
authors.initials: M
authors.lastname: Spina
authors.forename: Ferdinando
authors.initials: F
authors.lastname: Martellotta
authors.forename: Antonino
authors.initials: A
authors.lastname: Carbone
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D001706:Biopsy; D003287:Contrast Media; D015150:Echocardiography, Doppler; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000000981:diagnostic imaging* / Q000628:therapy; D016393:Lymphoma, B-Cell / Q000000981:diagnostic imaging* / Q000628:therapy; D008297:Male; D009206:Myocardium / Q000473:pathology*; D009361:Neoplasm Invasiveness; D010743:Phospholipids; D011237:Predictive Value of Tests; D018714:Radiotherapy, Adjuvant; D013459:Sulfur Hexafluoride; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D019380:Anti-HIV Agents; D003287:Contrast Media; D010743:Phospholipids; C420843:contrast agent BR1; D013459:Sulfur Hexafluoride