title: Wavefront-guided and aspheric ablation for myopia -- one-year results of the zyoptix personalized treatment advanced algorithm.
abstract: OBJECTIVE
  To evaluate the visual outcome and change in higher-order aberrations (HOAs) 1 year post simultaneous wavefront-guided and aspheric photorefractive keratectomy (PRK) and laser in situ keratomileusis (LASIK).
  
  
  METHODS
  Prospective interventional case series.
  
  
  METHODS
  Consecutive myopic patients undergoing PRK (38 eyes of 23 patients) and LASIK (42 eyes of 25 patients) using the Technolas 217z100 excimer laser (Technolas Perfect Vision) in a private laser clinic were included. Main outcome measures were uncorrected distance visual acuity (UDVA), manifest refraction (MRSE), HOAs, and spherical aberration (Z(4)(0)).
  
  
  RESULTS
  At 1 year, 87% (32/37) of PRK eyes and 81% (30/37) of LASIK eyes had UDVA of 20/20 or better (P = .75). Mean ± SD MRSE was -0.26 ± 0.31 diopters (D) in the PRK and -0.16 ± 0.34 D in the LASIK group (P = .222). There was no significant increase in total HOA root mean square (RMS) in the PRK group. Mean ± SD total HOA RMS increased from 0.402 ± 0.14 μm to 0.496 ± 0.17 μm (P = .013) in the LASIK group at 1 year. Z(4)(0) increased from mean ± SD -0.045 ± 0.12 μm to -0.109 ± 0.15 μm (P = .006, factor 2.42) in the PRK group and did not significantly increase in the LASIK group (mean ± SD -0.16 ± 0.17 μm to -0.17 ± 0.15 μm (P = .469, factor 1.08) at 6 mm pupil.
  
  
  CONCLUSIONS
  Visual outcome was excellent in both treatment groups. HOAs were still increased following LASIK by a factor of 1.23 but not PRK. Z(4)(0) was not induced by LASIK with the treatment algorithm but was negatively induced in PRK eyes.
authors.affiliation: Department of Refractive Surgery, Mater Private Hospital, Dublin, Ireland.
authors.forename: Andrea
authors.initials: A
authors.lastname: Ryan
authors.forename: Michael
authors.initials: M
authors.lastname: O'Keefe
mesh_terms: D000328:Adult; D000465:Algorithms; D001251:Astigmatism / Q000503:physiopathology / Q000601:surgery; D057108:Corneal Wavefront Aberration / Q000503:physiopathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D020731:Keratomileusis, Laser In Situ; D054018:Lasers, Excimer / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000503:physiopathology / Q000601:surgery*; D017060:Patient Satisfaction; D018903:Photorefractive Keratectomy; D011446:Prospective Studies; D012029:Refraction, Ocular / Q000502:physiology; D019233:Retreatment; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology; D055815:Young Adult