title: What we know about the generation of nystagmus and other ocular oscillations: are we closer to identifying therapeutic targets?
abstract: Mechanisms underlying acquired nystagmus are better understood than those leading to infantile nystagmus. Accordingly, further progress has been made in the development of effective therapies for acquired nystagmus, mainly through pharmacological interventions. Some of these therapies have been developed under the guidance of findings from experimental animal models. Although mechanisms behind infantile nystagmus are less understood, progress has been made in determining the genetic basis of nystagmus and characterizing associated sensory deficits. Pharmacological, surgical, and other treatments options for infantile nystagmus are now emerging. Further investigations are required for all forms of nystagmus to produce high-quality evidence, such as randomized controlled trials, upon which clinicians can make appropriate treatment decisions.
authors.affiliation: Leicester Royal Infirmary, Ophthalmology Group, University of Leicester, Faculty of Medicine & Biological Sciences, PO Box 65, Leicester LE2 7LX, UK. rjm19@le.ac.uk
authors.forename: Rebecca Jane
authors.initials: RJ
authors.lastname: McLean
authors.forename: Irene
authors.initials: I
authors.lastname: Gottlob
authors.forename: Frank Antony
authors.initials: FA
authors.lastname: Proudlock
mesh_terms: D005133:Eye Movements / Q000502:physiology*; D056228:Feedback, Sensory; D006801:Humans; D020417:Nystagmus, Congenital / Q000188:drug therapy / Q000235:genetics / Q000601:surgery; D009759:Nystagmus, Pathologic / Q000209:etiology / Q000235:genetics / Q000628:therapy