title: Lung volume reduction surgery for native lung hyperinflation following single-lung transplantation for emphysema: which patients?
abstract: OBJECTIVE
  Lung transplantation is an established treatment for patients with advanced emphysema. Double-lung transplantation is favoured to avoid complications following single-lung transplantation, including native lung hyperinflation. Nonetheless, single-lung transplantation continues due to limited donor organ availability. The aim of this study was to evaluate the pre-operative assessment, surgical techniques and outcomes in patients undergoing lung volume reduction surgery for native lung hyperinflation.
  
  
  METHODS
  Eight patients underwent lung volume reduction surgery for native lung hyperinflation between October 2008 and April 2011. Symptoms, pre-operative evaluation, peri-operative morbidity, length of stay, pulmonary function and survival were examined. The mean follow-up was 17 months.
  
  
  RESULTS
  Participants underwent high resolution CT and bronchoscopy with transbronchial biopsy and bronchial washings to exclude alternative causes for deterioration in pulmonary function tests. V/Q scan was performed to assess the contribution of each lung to overall function. Measurement of inspiratory airflow resistance in each lung was performed in one case. Seven patients underwent multiple wedge resections and one underwent bilobectomy. All patients survived to hospital discharge, and mean length of stay was 13.9 days. Functional improvement was demonstrated in all cases at follow-up, with a mean percentage increase of 29.3% in forced expiratory volume in one second and 21.6% in forced vital capacity. Symptomatic improvement was also reported by all patients post-operatively.
  
  
  CONCLUSIONS
  Lung volume reduction surgery for native lung hyperinflation is an effective treatment strategy with an acceptable level of surgical risk. Patient selection, however, remains vital. The non-anatomical multiple wedge excision technique used here was as effective as anatomical lung volume reduction surgery used in other series. With regard to pre-operative assessment, the measurement of single-lung inspiratory airflow resistance is of particular interest. We feel that this may provide an additional method of differentiating between native lung hyperinflation and obliterative bronchiolitis prior to surgery, thus improving patient selection.
authors.affiliation: Harefield Hospital, Uxbridge, Middlesex, UK. hmwilson@doctors.org.uk
authors.forename: Henrietta
authors.initials: H
authors.lastname: Wilson
authors.forename: Martin
authors.initials: M
authors.lastname: Carby
authors.forename: Emma
authors.initials: E
authors.lastname: Beddow
mesh_terms: D001999:Bronchoscopy / Q000379:methods; D016208:Databases, Factual; D005260:Female; D005500:Follow-Up Studies; D006085:Graft Survival; D017052:Hospital Mortality; D006801:Humans; D007902:Length of Stay; D016040:Lung Transplantation / Q000009:adverse effects / Q000379:methods*; D008297:Male; D018579:Patient Selection; D011013:Pneumonectomy / Q000009:adverse effects / Q000379:methods* / Q000401:mortality*; D011183:Postoperative Complications / Q000401:mortality / Q000503:physiopathology; D029424:Pulmonary Disease, Chronic Obstructive / Q000000981:diagnostic imaging / Q000401:mortality / Q000601:surgery*; D011656:Pulmonary Emphysema / Q000175:diagnosis / Q000401:mortality / Q000601:surgery; D012129:Respiratory Function Tests; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D015996:Survival Rate; D014057:Tomography, X-Ray Computed / Q000379:methods; D016896:Treatment Outcome