title: Silybum marianum (milk thistle) in the management and prevention of hepatotoxicity in a patient undergoing reinduction therapy for acute myelogenous leukemia.
abstract: Hepatotoxicity has been observed with several chemotherapy agents and combination regimens. Conventional treatment methods often include supportive care or observation. We report a case of a patient with noted transaminitis presumed secondary to chemotherapy, which did not resolve with supportive care but was shown to respond to milk thistle. The patient had an immediate decrease in liver function tests and showed decreased elevation in levels upon treatment with subsequent chemotherapy regimens. This case demonstrates the potential efficacy of milk thistle as a unique hepatoprotective agent.
authors.affiliation: Arthur G. James Cancer Hospital, The Ohio State University Department of Pharmacy, Columbus, OH 43210, USA. alimcbride@gmail.com
authors.forename: Ali
authors.initials: A
authors.lastname: McBride
authors.forename: Kristan M
authors.initials: KM
authors.lastname: Augustin
authors.forename: Julie
authors.initials: J
authors.lastname: Nobbe
authors.forename: Peter
authors.initials: P
authors.lastname: Westervelt
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy; D008111:Liver Function Tests; D008875:Middle Aged; D020944:Silybum marianum / Q000737:chemistry*; D008517:Phytotherapy / Q000379:methods; D010936:Plant Extracts / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D010936:Plant Extracts