title: Improvement of lipid profile and reduction of body weight by shan he jian fei granules in high fat diet-induced obese rats.
abstract: BACKGROUND
  The goal was to study lipid profiles (TG, TC, LDL, HDL), effects on serum leptin, and fat tissue adiponectin, and resistin as well as body weight effects of Shan He Jian Fei Granules (SHJFG) in rats on a high fat diet.
  
  
  METHODS
  Rats were randomly divided into five groups: normal control group fed with normal fat diet, rats on high fat diet receiving low dosage, middle dosage, high dosage of Shan He Jian Fei Granules (SHJFG) as well as a high fat diet group receiving placebo. Rats were treated for 8 weeks. Body weight and naso-anal length of each rat were recorded and Lee's index was calculated. Serum TG, TC, LDL, HDL and leptin concentrations were analyzed. The gene expressions of adiponectin and resistin in adipose tissues were tested by RT-PCR.
  
  
  RESULTS
  Compared to the high-fat diet group, body weights, Lee's indexes, weight of fat tissues and serum TG, TC, LDL and leptin of SHJFG groups significantly decreased (p < 0.05), whereas mRNA expressions of adiponectin and resistin of SHJFG groups significantly increased (p < 0.05).
  
  
  CONCLUSIONS
  SHJFG could significantly lower body weight and serum TG, TC, and LDL of obese rats. The effects of SHJFG in lowering leptin synthesis and raising mRNA expression of adiponectin and resistin in fat tissues may act as part of the mechanisms in lowering body weight of obese rats. Further studies are needed to demonstrate whether SHJFG may also reduce overall cardiovascular morbidity and mortality like other lipid lowering drugs.
authors.affiliation: Institute of Qi and Blood of Integrative Medicine, Jinan University, Guangzhou 510630, China. tsunsy@jnu.edu.cn
authors.forename: Sheng-Yun
authors.initials: SY
authors.lastname: Sun
authors.forename: Jin
authors.initials: J
authors.lastname: Huang
authors.forename: Min-Jie
authors.initials: MJ
authors.lastname: Meng
authors.forename: Jia-Hai
authors.initials: JH
authors.lastname: Lu
authors.forename: Berthold
authors.initials: B
authors.lastname: Hocher
authors.forename: Kang-Li
authors.initials: KL
authors.lastname: Liu
authors.forename: Qin-He
authors.initials: QH
authors.lastname: Yang
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Zhu
mesh_terms: D052242:Adiponectin / Q000235:genetics / Q000378:metabolism; D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D004041:Dietary Fats / Q000008:administration & dosage*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D015870:Gene Expression / Q000187:drug effects; D020738:Leptin / Q000097:blood; D050356:Lipid Metabolism / Q000187:drug effects*; D008055:Lipids / Q000097:blood*; D008297:Male; D009765:Obesity / Q000097:blood / Q000188:drug therapy*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D052243:Resistin / Q000235:genetics / Q000378:metabolism; D015431:Weight Loss / Q000187:drug effects
chemical_list: D052242:Adiponectin; D004041:Dietary Fats; D004365:Drugs, Chinese Herbal; D020738:Leptin; D008055:Lipids; D012333:RNA, Messenger; D052243:Resistin; C499622:Retn protein, rat