title: Acyl and silyl group effects in reactivity-based one-pot glycosylation: synthesis of embryonic stem cell surface carbohydrates Lc4 and IV(2)Fuc-Lc4.
abstract: Relative reactivity evaluations showed the graded arming of toluenyl thioglucosides by variously positioned silyl groups but not by their acyl counterparts. These findings were applied in reactivity-based one-pot assembly of linker-attached Lc(4) and IV(2)Fuc-Lc(4), which are components of human embryonic stem cell surface. The sugar-galectin-1 binding was also examined.
authors.affiliation: Genomics Research Center, Academia Sinica, 128, Section 2, Academia Road, Taipei 115, Taiwan.
authors.forename: Yun
authors.initials: Y
authors.lastname: Hsu
authors.forename: Xin-An
authors.initials: XA
authors.lastname: Lu
authors.forename: Medel Manuel L
authors.initials: MM
authors.lastname: Zulueta
authors.forename: Chih-Ming
authors.initials: CM
authors.lastname: Tsai
authors.forename: Kuo-I
authors.initials: KI
authors.lastname: Lin
authors.forename: Shang-Cheng
authors.initials: SC
authors.lastname: Hung
authors.forename: Chi-Huey
authors.initials: CH
authors.lastname: Wong
mesh_terms: D002240:Carbohydrate Sequence; D053595:Embryonic Stem Cells / Q000737:chemistry*; D005643:Fucose / Q000737:chemistry*; D006031:Glycosylation; D008969:Molecular Sequence Data
chemical_list: D005643:Fucose