title: Relationships among blood leptin and adiponectin levels, fat mass, and bone mineral density in Japanese pre- and postmenopausal women.
abstract: We conducted a survey of 111 healthy middle-aged and older women, aged 40 to 80 years, to elucidate the relationships between blood leptin and adiponectin levels and bone mineral density (BMD) in September 2008. We examined the associations between the blood levels of these adipocytokines and the lumbar spine (L2-L4), left femoral, and distal forearm BMD after adjustment for the age and body fat percentage. No correlation was observed between leptin and the BMD. This is presumably due to the fact that the influence of menopause, age, duration of postmenopausal period, and body fat percentage on the BMD is greater than that of leptin levels in healthy women. The adiponectin levels were significantly correlated negatively with the lumbar spine and femoral BMD in premenopausal women, and with forearm BMD in postmenopausal women, regardless of adjustment for age and body fat percentage. It seems likely that adiponectin influences the BMD at different skeletal sites in pre- and postmenopausal women.
authors.affiliation: Department of Public Health, Fujita Health University School of Medicine, Toyoake, Aichi 470-1192, Japan. iida@fujita-hu.ac.jp
authors.forename: Tadayuki
authors.initials: T
authors.lastname: Iida
authors.forename: Tokio
authors.initials: T
authors.lastname: Domoto
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takigawa
authors.forename: Satoru
authors.initials: S
authors.lastname: Nakamura
authors.forename: Yoji
authors.initials: Y
authors.lastname: Kato
authors.forename: Masanori
authors.initials: M
authors.lastname: Togo
authors.forename: Chiho
authors.initials: C
authors.lastname: Chikamura
authors.forename: Toshihide
authors.initials: T
authors.lastname: Harada
authors.forename: Fumiko
authors.initials: F
authors.lastname: Ishizaki
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Ono
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density; D005260:Female; D006801:Humans; D007564:Japan; D020738:Leptin / Q000097:blood*; D008875:Middle Aged; D017698:Postmenopause; D017697:Premenopause
chemical_list: D052242:Adiponectin; D020738:Leptin