title: [Influence of perftoran on pharmacokinetics of hydrophilic drugs].
abstract: Influence of perfluorocarbon blood substitute Perftoran on pharmacokinetics of cefazolin (20 mg/kg), cefotaxime (25 mg/kg), ciprofloxacin (4 mg/kg) and pentoxifylline (10 mg/kg) upon their intravenous introduction separately or immediately after Perftoran infusion (5 ml/kg) was investigated on rabbits. It was found that the presence of Perftoran accelerated the transfer from blood to tissues for Cefazolin and Cefotaxime, which have negative values of the distribution logarithm in octanol/water (logP = -0.4 and -1.4, respectively). With respect to pentoxifylline and ciprofloxacin, which are less hydrophilic, the effect of pharmacokinetic interference was either weaker or absent. Probably, the infusion of hydrophobic Perftoran nanoemulsion enhances the hydrophobicity of blood plasma, which is a prerequisite for the more intensive transfer of hydrophilic ligands from blood to tissues.
authors.forename: N N
authors.initials: NN
authors.lastname: Pshenkina
mesh_terms: D000818:Animals; D001802:Blood Substitutes / Q000494:pharmacology*; D002437:Cefazolin / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics*; D002439:Cefotaxime / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics*; D002939:Ciprofloxacin / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics*; D004347:Drug Interactions; D005466:Fluorocarbons / Q000494:pharmacology*; D057927:Hydrophobic and Hydrophilic Interactions; D007275:Injections, Intravenous; D008297:Male; D010431:Pentoxifylline / Q000097:blood / Q000737:chemistry / Q000493:pharmacokinetics*; D011817:Rabbits
chemical_list: D001802:Blood Substitutes; D005466:Fluorocarbons; D002939:Ciprofloxacin; C063334:perftoran; D002437:Cefazolin; D002439:Cefotaxime; D010431:Pentoxifylline