title: A dual cytotoxic and anti-angiogenic water-soluble gold(III) complex induces endoplasmic reticulum damage in HeLa cells.
abstract: The water-soluble gold(III) complex [Au(III)(butyl-C^N)biguanide]Cl (butyl-HC^N = 2-(4-n-butylphenyl)pyridine, BCN) displays cytotoxicity through S-phase cell cycle arrest and endoplasmic reticulum (ER) damage in HeLa cells, and shows a promising anti-angiogenic effect at sub-cytotoxic concentrations.
authors.affiliation: Department of Chemistry and Open Laboratory of Chemical Biology of the Institute of Molecular Technology for Drug Discovery and Synthesis, The University of Hong Kong, Pokfulam Road, Hong Kong.
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Zhang
authors.forename: Raymond Wai-Yin
authors.initials: RW
authors.lastname: Sun
authors.forename: Chi-Ming
authors.initials: CM
authors.lastname: Che
mesh_terms: D020533:Angiogenesis Inhibitors / Q000494:pharmacology / Q000633:toxicity*; D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004721:Endoplasmic Reticulum / Q000187:drug effects* / Q000473:pathology; D059865:Endoplasmic Reticulum Stress / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D051379:Mice; D050607:Organogold Compounds / Q000494:pharmacology / Q000633:toxicity*; D012995:Solubility; D014867:Water / Q000737:chemistry
chemical_list: D020533:Angiogenesis Inhibitors; D050607:Organogold Compounds; D014867:Water