title: Functional properties of granulocytes after thermal injury.
abstract: Thermal injury, as well as other forms of severe trauma, induces simultaneous hyper- and anti-inflammatory response. While data about decreased number and responsiveness of T lymphocytes are largely consistent, reports concerning granulocytes following trauma are contradictory. Contrary to the evidence on the increased accumulation of granulocytes in the lungs or liver, the results from our laboratory demonstrated reduced granulocyte influx in the wound that heals in conditions of thermal injury. We also demonstrated evidence that indicates impaired signal transduction in granulocytes following thermal injury, as well as their divergent response regarding the adhesiveness, oxidative burst and nitric oxide production at the wound site.
authors.affiliation: Medical Faculty of the Military Medical Academy, University of Defense in Belgrade, Crnotravska 17, 11002 Belgrade, Serbia.
authors.forename: Biljana
authors.initials: B
authors.lastname: Draskovic-Pavlovic
authors.forename: Dragana
authors.initials: D
authors.lastname: Vucevic
authors.forename: Biljana
authors.initials: B
authors.lastname: Bozic
authors.forename: Ivana
authors.initials: I
authors.lastname: Majstorovic
authors.forename: Miodrag
authors.initials: M
authors.lastname: Colic
mesh_terms: D002056:Burns / Q000276:immunology*; D039481:CD11b Antigen / Q000096:biosynthesis; D018821:CD18 Antigens / Q000096:biosynthesis; D002448:Cell Adhesion; D006098:Granulocytes / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D018836:Inflammation Mediators / Q000378:metabolism; D009569:Nitric Oxide / Q000096:biosynthesis; D016897:Respiratory Burst; D015398:Signal Transduction; D013312:Stress, Physiological; D013601:T-Lymphocytes / Q000276:immunology; D014945:Wound Healing
chemical_list: D039481:CD11b Antigen; D018821:CD18 Antigens; D018836:Inflammation Mediators; D009569:Nitric Oxide