title: Structure guided approaches toward exploiting and manipulating nonribosomal peptide and polyketide biosynthetic pathways.
abstract: Nonribosomal peptide and polyketide natural products are structurally diverse small molecules synthesized on complex enzyme assemblies. The ability to rationally engineer secondary metabolic pathways is a promising approach to novel therapeutics. Atomic resolution structures of biosynthetic enzymes provide information on active site architecture and macromolecular assembly that can aid in the engineering of new compounds. This review surveys recent applications toward biosynthetic engineering of natural products guided by structural biology.
authors.affiliation: Department of Chemistry, University of Florida, Gainesville, FL 32611, United States.
authors.forename: Heather L
authors.initials: HL
authors.lastname: Condurso
authors.forename: Steven D
authors.initials: SD
authors.lastname: Bruner
mesh_terms: D053898:Biosynthetic Pathways; D003500:Cyclization; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism; D061065:Polyketides / Q000737:chemistry* / Q000378:metabolism; D012270:Ribosomes / Q000378:metabolism
chemical_list: D010455:Peptides; D061065:Polyketides