title: Sec14 like PITPs couple lipid metabolism with phosphoinositide synthesis to regulate Golgi functionality.
abstract: An interface coordinating lipid metabolism with proteins that regulate membrane trafficking is necessary to regulate Golgi morphology and dynamics. Such an interface facilitates the membrane deformations required for vesicularization, forms platforms for protein recruitment and assembly on appropriate sites on a membrane surface and provides lipid co-factors for optimal protein activity in the proper spatio-temporally regulated manner. Importantly, Sec14 and Sec14-like proteins are a unique superfamily of proteins that sense specific aspects of lipid metabolism, employing this information to potentiate phosphoinositide production. Therefore, Sec14 and Sec14 like proteins form central conduits to integrate multiple aspects of lipid metabolism with productive phosphoinositide signaling.
authors.affiliation: Department of Cell & Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, 27599-7090, Chapel Hill, NC, USA, mousley@email.unc.edu.
authors.forename: Carl J
authors.initials: CJ
authors.lastname: Mousley
authors.forename: James M
authors.initials: JM
authors.lastname: Davison
authors.forename: Vytas A
authors.initials: VA
authors.lastname: Bankaitis
mesh_terms: D000818:Animals; D001692:Biological Transport; D002352:Carrier Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D004075:Diglycerides / Q000378:metabolism; D005786:Gene Expression Regulation; D006056:Golgi Apparatus / Q000502:physiology*; D006801:Humans; D050356:Lipid Metabolism; D008958:Models, Molecular; D018129:Phosphatidylinositol Phosphates / Q000096:biosynthesis*; D049294:Phospholipid Transfer Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D011485:Protein Binding; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D002352:Carrier Proteins; D004075:Diglycerides; D018129:Phosphatidylinositol Phosphates; D049294:Phospholipid Transfer Proteins; C483438:SEC14 protein, S cerevisiae; C100642:SEC14L1 protein, human; D029701:Saccharomyces cerevisiae Proteins; C030363:lipid transfer protein; C037178:phosphatidylinositol 4-phosphate