title: Course of pandemic influenza A(H1N1) 2009 virus infection in Dutch patients.
abstract: The clinical dynamics of influenza A(H1N1) 2009 infections in 61 laboratory-confirmed Dutch cases were examined. An episode lasted a median of 7·5 days of which 2 days included fever. Respiratory symptoms resolved slowly, while systemic symptoms peaked early in the episode and disappeared quickly. Severity of each symptom was rated highest in the first few days. Furthermore, diarrhoea was negatively associated with viral load, but not with faecal excretion of influenza virus. Cases with comorbidities appeared to have higher viral loads than the cases without, suggesting a less effective immune response. These results complement information obtained through traditional surveillance.
authors.affiliation: National Institute for Public Health and the Environment (RIVM), Centre for Infectious Disease Control, Bilthoven, The Netherlands. ingrid.friesema@rivm.nl
authors.forename: Ingrid H M
authors.initials: IH
authors.lastname: Friesema
authors.forename: Adam
authors.initials: A
authors.lastname: Meijer
authors.forename: Arianne B
authors.initials: AB
authors.lastname: van Gageldonk-Lafeber
authors.forename: Mariken
authors.initials: M
authors.lastname: van der Lubben
authors.forename: Janko
authors.initials: J
authors.lastname: van Beek
authors.forename: Gé A
authors.initials: GA
authors.lastname: Donker
authors.forename: Jan M
authors.initials: JM
authors.lastname: Prins
authors.forename: Menno D
authors.initials: MD
authors.lastname: de Jong
authors.forename: Simone
authors.initials: S
authors.lastname: Boskamp
authors.forename: Leslie D
authors.initials: LD
authors.lastname: Isken
authors.forename: Marion P G
authors.initials: MP
authors.lastname: Koopmans
authors.forename: Marianne A B
authors.initials: MA
authors.lastname: van der Sande
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003967:Diarrhea / Q000209:etiology / Q000821:virology; D004196:Disease Outbreaks; D005260:Female; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000235:genetics / Q000302:isolation & purification* / Q000502:physiology; D007251:Influenza, Human / Q000150:complications / Q000453:epidemiology* / Q000821:virology; D008297:Male; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D058873:Pandemics; D019562:Viral Load; D055815:Young Adult