title: IL1A-889 C/T gene polymorphism in irritant contact dermatitis.
abstract: BACKGROUND
  Upon skin contact to irritants, interleukin-1 alpha (IL-1α) is released in the stratum corneum as a primary step of skin inflammation. Variations in the IL-1A gene have been shown to alter the expression of IL-1α. This may influence the susceptibility to skin inflammation and the development of irritant contact dermatitis (ICD).
  
  
  OBJECTIVE
  To determine effects of an IL1A-889 C/T polymorphism in view of susceptibility to develop irritant contact dermatitis.
  
  
  METHODS
  In a case-control study, 478 Caucasian patients with occupational ICD of the hands were genotyped for an IL1A-889 C/T polymorphism. Results were compared to 393 apprentices from the same high risk occupations (controls).
  
  
  RESULTS
  Trends of a protective effect of the C → T transition at position IL1A-889 were seen (OR = 0.81; 95% CI: 0.65-1.00). The genotype distribution for IL1A-889 was 52.2% wild type (C/C), 39.2% heterozygous (C/T) and 8.6% homozygous for variant allele (T/T) in patients and 46.0%, 42.7% and 11.4% in controls. Subgroup analysis, which took into account atopy status and exposure, did not reveal a significant effect of this polymorphism for an aberrant risk to acquire for ICD.
  
  
  CONCLUSIONS
  Our study indicates a possible protective effect of the IL1A-889 C/T polymorphism regarding the development of ICD.
authors.affiliation: Department of Dermatology, Environmental Medicine and Health Theory, University of Osnabrück, Osnabrück, Germany. llandeck@uos.de
authors.forename: L
authors.initials: L
authors.lastname: Landeck
authors.forename: M
authors.initials: M
authors.lastname: Visser
authors.forename: S
authors.initials: S
authors.lastname: Kezic
authors.forename: S M
authors.initials: SM
authors.lastname: John
mesh_terms: D003877:Dermatitis, Contact / Q000209:etiology / Q000235:genetics*; D006801:Humans; D053582:Interleukin-1alpha / Q000235:genetics*; D007509:Irritants / Q000633:toxicity*; D011110:Polymorphism, Genetic
chemical_list: D053582:Interleukin-1alpha; D007509:Irritants