title: Role of oxidative stress in preeclampsia and intrauterine growth restriction.
abstract: OBJECTIVE
  The aim of the present study was to evaluate the role of oxidative stress and DNA damage in preeclampsia and intrauterine growth restriction (IUGR).
  
  
  METHODS
  Twenty-four patients with preeclampsia, 20 patients with IUGR fetus and 37 healthy pregnant women were enrolled in the study. The total oxidant status (TOS) and antioxidant status (TAS) of plasma were measured using a novel automated colorimetric measurement method. Sister chromatid exchange (SCE) and micronuclei analysis were performed on peripheral blood lymphocytes of cases and controls.
  
  
  RESULTS
  Women whose pregnancies were complicated with preeclampsia and IUGR had elevated levels of TOS and TAS when compared with healthy pregnant women (median TOS values: 9.73, 10.6 and 8.06, P = 0.001; median TAS values: 1. 77, 1.54 and 1.44, P < 0.001, respectively). The frequencies of SCE were only found to be increased in women with IUGR fetus compared with healthy pregnant women (8.81 vs 7.5, respectively, P = 0.02). Multivariable linear regression analysis for both TOS and TAS showed a significant relation between these variables and uric acid.
  
  
  CONCLUSIONS
  Increased oxidative stress and antioxidative defense mechanisms may contribute to disease processes both in preeclampsia and IUGR.
authors.affiliation: Department of Obstetrics and Gynecology, Wayne State University, Detroit Medical Center, Hutzel Women's Hospital, 3990 John R Street, 7 Brush North Detroit, Detroit, MI 48201, USA. isomert2002@yahoo.com
authors.forename: Ismail
authors.initials: I
authors.lastname: Mert
authors.forename: Ayla Sargin
authors.initials: AS
authors.lastname: Oruc
authors.forename: Serdar
authors.initials: S
authors.lastname: Yuksel
authors.forename: Esra Sukran
authors.initials: ES
authors.lastname: Cakar
authors.forename: Umran
authors.initials: U
authors.lastname: Buyukkagnici
authors.forename: Abdullah
authors.initials: A
authors.lastname: Karaer
authors.forename: Nuri
authors.initials: N
authors.lastname: Danisman
mesh_terms: D000293:Adolescent; D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology* / Q000378:metabolism; D006801:Humans; D016014:Linear Models; D048629:Micronuclei, Chromosome-Defective; D018384:Oxidative Stress; D011225:Pre-Eclampsia / Q000209:etiology* / Q000378:metabolism; D011247:Pregnancy; D012854:Sister Chromatid Exchange
chemical_list: D000975:Antioxidants