title: Prevalence of perinuclear antineutrophilic cytoplasmic autoantibodies in serum of healthy Soft Coated Wheaten Terriers in the United Kingdom.
abstract: OBJECTIVE
  To estimate the prevalence of perinuclear antineutrophilic cytoplasmic autoantibodies (pANCA) in the serum of healthy Soft Coated Wheaten Terriers (SCWTs) in the United Kingdom and to identify potential risk factors and heritability patterns associated with a positive result for pANCA.
  
  
  METHODS
  188 SCWTs (age range, 18 months to 14.3 years).
  
  
  METHODS
  Blood samples were obtained from SCWTs in various locations in England. Serum was tested for pANCA by use of an immunofluorescence assay, and total protein and albumin concentrations were determined. Pedigrees were evaluated to identify close relatives that had protein-losing enteropathy (PLE) or protein-losing nephropathy (PLN).
  
  
  RESULTS
  39 of 188 (20.7%) dogs, including young dogs, had positive results for pANCA. Dogs had significantly higher odds of having positive results for pANCA if they had at least 1 littermate that had PLE or PLN (odds ratio, 12.1) or if they had at least 1 full sibling from another litter known to be affected with PLE or PLN (odds ratio, 4.0). CONCLUSIONS AND CLINICAL RELEVANCE; This study revealed a high prevalence of pANCA in the serum of a representative sample of healthy SCWTs in the United Kingdom and a significant association between positive results for pANCA and a diagnosis of PLE or PLN in a sibling.
authors.affiliation: Department of Veterinary Clinical Sciences, Royal Veterinary College, University of London, North Mymms, Hatfield, Hertfordshire, AL9 7TA, England. bwieland@rvc.ac.uk
authors.forename: Barbara
authors.initials: B
authors.lastname: Wieland
authors.forename: Jennifer F
authors.initials: JF
authors.lastname: Summers
authors.forename: Barbara
authors.initials: B
authors.lastname: Häsler
authors.forename: Carolina
authors.initials: C
authors.lastname: Mancho-Alonso
authors.forename: Amanda
authors.initials: A
authors.lastname: Craig
authors.forename: Karin
authors.initials: K
authors.lastname: Allenspach
mesh_terms: D000818:Animals; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D001323:Autoantibodies / Q000097:blood*; D004283:Dog Diseases / Q000097:blood / Q000453:epidemiology / Q000276:immunology*; D004285:Dogs; D004739:England; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect / Q000662:veterinary; D007674:Kidney Diseases / Q000150:complications / Q000453:epidemiology / Q000276:immunology / Q000662:veterinary*; D008297:Male; D010375:Pedigree; D015995:Prevalence; D011504:Protein-Losing Enteropathies / Q000150:complications / Q000453:epidemiology / Q000276:immunology / Q000662:veterinary*; D012307:Risk Factors
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies