title: Polymorphism of DNA repair gene XRCC1 and hepatocellular carcinoma risk in Chinese population.
abstract: OBJECTIVE
  We conducted a case-control study in China to clarify the association between the XRCC1-Arg399Gln polymorphism and HCC risk.
  
  
  METHODS
  A total of 202 cases and 236 controls were selected from the the Affiliated Hospital of Qingdao University from May 2008 to May 2010. Assessment of the XRCC1-Arg399Gln polymorphism was based upon duplex polymerase-chain-reactions with the confronting-two-pair primer (PCR- CTPP) method. All analyses were performed using the STATA statistical package.
  
  
  RESULTS
  A significant increase in risk was associated with the Arg/Gln genotype (adjusted OR 1.55, 95%CI=1.03-2.57) compared with Arg/ Arg. However, the Gln/Gln genotype had non-significant increased risk of HCC with adjusted OR (95%CI) of 1.34(0.67-2.38). There was also a significant increase with the Arg/Gln genotype among HCC patients above 50 years old (OR=1.95, 95% CI=1.14-3.57). Additionally, the risk of HCC was moderately increased in drinkers with Arg/Gln genotype compared with never drinkers, and the adjusted OR (95% CI) was 1.89 (1.13-3.45).
  
  
  CONCLUSIONS
  This study demonstrated that a polymorphism in a DNA repair gene may influence the risk of HCC. The XRCC1 codon Arg/Gln was this associated with an increased risk of HCC, especially in patients above 50 years old and/or with a drinking habit.
authors.affiliation: Department of Laboratory, Medical College of Qingdao University, Qingdao, China.
authors.forename: Hua-zheng
authors.initials: HZ
authors.lastname: Pan
authors.forename: Jun
authors.initials: J
authors.lastname: Liang
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Yu
authors.forename: Li-min
authors.initials: LM
authors.lastname: Lun
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Qing
authors.initials: Q
authors.lastname: Wang
mesh_terms: D000328:Adult; D000367:Age Factors; D000428:Alcohol Drinking; D000483:Alleles; D019943:Amino Acid Substitution; D006528:Carcinoma, Hepatocellular / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008113:Liver Neoplasms / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D000076105:X-ray Repair Cross Complementing Protein 1
chemical_list: D004268:DNA-Binding Proteins; D000076105:X-ray Repair Cross Complementing Protein 1; C000619371:XRCC1 protein, human