title: Chitosan and fish collagen as biomaterials for regenerative medicine.
abstract: This chapter focuses and reviews on the characteristics and biomedical application of chitosan and collagen from marine products and advantages and disadvantages of regeneration medicine. The understanding of the production processes of chitosan and collagen and the conformation of these biomaterials are indispensable for promoting the theoretical and practical availability. The initial inflammatory reactions associated with chitosan application to hard and soft tissues need to be controlled before it can be considered for clinical application as scaffold. Further, as chitosan takes too long for biodegradation in vivo, generally it is not suitable for the scaffold for degenerative medicine in especially dental pulp tissue. The collagen extract from the scales of tropical fish has been reported to have a degeneration temperature of 35°C. The properties of biocompatibility and biodegradation of fish atelocollagen are suitable for the scaffold in regenerative medicine.
authors.affiliation: Department of Cariology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan. hayashi@nagasaki-u.ac.jp
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Shizuka
authors.initials: S
authors.lastname: Yamada
authors.forename: Kajiro
authors.initials: K
authors.lastname: Yanagi Guchi
authors.forename: Zenya
authors.initials: Z
authors.lastname: Koyama
authors.forename: Takeshi
authors.initials: T
authors.lastname: Ikeda
mesh_terms: D000818:Animals; D059001:Aquatic Organisms / Q000737:chemistry*; D001672:Biocompatible Materials / Q000009:adverse effects / Q000737:chemistry* / Q000378:metabolism; D048271:Chitosan / Q000009:adverse effects / Q000737:chemistry* / Q000378:metabolism; D003094:Collagen / Q000009:adverse effects / Q000737:chemistry* / Q000378:metabolism; D029941:Fish Proteins / Q000009:adverse effects / Q000737:chemistry* / Q000378:metabolism; D005512:Food Hypersensitivity / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology; D008968:Molecular Conformation; D044968:Regenerative Medicine / Q000379:methods; D023822:Tissue Engineering; D054457:Tissue Scaffolds / Q000009:adverse effects / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D029941:Fish Proteins; D003094:Collagen; D048271:Chitosan