title: Cutis laxa: a review.
abstract: Cutis laxa is a rare disorder of elastic tissue resulting in loose, redundant, hypoelastic skin. Both acquired and inherited forms exist, some of which have significant systemic manifestations. Here, we review the various forms of cutis laxa, with focus on the inherited forms. Recent molecular studies have provided many new insights into the causes of cutis laxa and revealed greater genetic heterogeneity than previously appreciated.
authors.affiliation: Department of Internal Medicine, Division of Dermatology, Washington University School of Medicine and St Louis Children's Hospital, St Louis, Missouri 63110, USA. dberk@dom.wustl.edu
authors.forename: David R
authors.initials: DR
authors.lastname: Berk
authors.forename: Danette D
authors.initials: DD
authors.lastname: Bentley
authors.forename: Susan J
authors.initials: SJ
authors.lastname: Bayliss
authors.forename: Anne
authors.initials: A
authors.lastname: Lind
authors.forename: Zsolt
authors.initials: Z
authors.lastname: Urban
mesh_terms: D000015:Abnormalities, Multiple / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics; D001707:Biopsy, Needle; D003483:Cutis Laxa / Q000453:epidemiology / Q000235:genetics* / Q000473:pathology*; D004547:Elastic Tissue / Q000473:pathology; D016326:Extracellular Matrix Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology*; D006801:Humans; D007150:Immunohistochemistry; D015994:Incidence; D008297:Male; D011379:Prognosis; D018570:Risk Assessment; D012720:Severity of Illness Index
chemical_list: C403672:EFEMP2 protein, human; D016326:Extracellular Matrix Proteins; C492373:FBLN5 protein, human