title: Quality-of-life, mood and executive functioning after childhood craniopharyngioma treated with surgery and proton beam therapy.
abstract: OBJECTIVE
  Childhood craniopharyngioma, a benign tumour with a good survival rate, is associated with important neurocognitive and psychological morbidity, reducing quality-of-life (QoL).
  
  
  METHODS
  This retrospective study analysed QoL, mood disorders, everyday executive functioning and disease's impact on family life in 29 patients (mean age at diagnosis 7 years 10 months (SD = 4.1); mean follow-up period 6 years 2 months (SD = 4.5)) treated for childhood craniopharyngioma by surgery combined with radiotherapy using proton beam. Assessment included a semi-structured interview and standardized scales evaluating self-report of QoL (Kidscreen 52) and depression (MDI-C) and proxy-reports of QoL (Kidscreen 52), executive functioning (BRIEF) and disease's impact (Hoare and Russel Questionnaire).
  
  
  RESULTS
  Twenty-three families answered the questionnaires completely. Overall QoL self-report was within the normal range. QoL proxy-report was lower than self-report. Eleven patients reported depression; 24-38% had dysexecutive symptoms. A majority of families felt 'very concerned' by the disease. Depression and low parental educational level were associated with lower QoL and higher levels of executive dysfunction.
  
  
  CONCLUSIONS
  Given the high morbidity of childhood craniopharyngioma, screening for psychosocial outcome, cognitive functioning, including executive functions, mood and QoL should be systematic and specific interventions should be developed and implemented.
authors.affiliation: Rehabilitation Department for Children with Acquired Neurological Injuries, Hôpitaux de Saint Maurice, Saint Maurice, France.
authors.forename: C
authors.initials: C
authors.lastname: Laffond
authors.forename: G
authors.initials: G
authors.lastname: Dellatolas
authors.forename: C
authors.initials: C
authors.lastname: Alapetite
authors.forename: S
authors.initials: S
authors.lastname: Puget
authors.forename: J
authors.initials: J
authors.lastname: Grill
authors.forename: J-L
authors.initials: JL
authors.lastname: Habrand
authors.forename: F
authors.initials: F
authors.lastname: Doz
authors.forename: M
authors.initials: M
authors.lastname: Chevignard
mesh_terms: D000203:Activities of Daily Living; D000293:Adolescent; D000339:Affect; D002648:Child; D002675:Child, Preschool; D003397:Craniopharyngioma / Q000523:psychology* / Q000628:therapy*; D003863:Depression / Q000209:etiology; D056344:Executive Function; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009483:Neuropsychological Tests; D010911:Pituitary Neoplasms / Q000523:psychology* / Q000628:therapy*; D061766:Proton Therapy; D011788:Quality of Life; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D057566:Self Report; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D011522:Protons
chemical_list: D011522:Protons