title: Serum albumin is a useful prognostic indicator and adds important information to NT-proBNP in a Chinese cohort of heart failure.
abstract: OBJECTIVE
  To evaluate the effect of serum albumin on prognosis and the power of albumin adding information to NT-proBNP in a Chinese cohort of heart failure.
  
  
  METHODS
  385 consecutive patients (male vs. female: 292 vs. 93; mean age: 54.89±14.41years; NYHA classes II-V) admitted for heart failure exacerbation with LVEF≤45% were enrolled, and biochemical data was measured at baseline. The endpoint was defined as cardiac death or rehospitalization for aggravated heart failure. Follow-up period was 25±7months.
  
  
  RESULTS
  Multivariate analysis in a Cox proportional hazard model revealed serum albumin was an independent predictor for adverse prognosis (HR 0.96,CI 0.94-0.99, P=0.02), and the patients with higher NT-proBNP and lower albumin than median had the highest risk for cardiac events (HR 2.89, CI 1.90-4.40, P<0.01).
  
  
  CONCLUSIONS
  Serum albumin is a significant prognosis indicator for heart failure and it adds important information to NT-proBNP.
authors.affiliation: Department of Emergency Center, Fuwai Hospital & Cardiovascular Institute, Chinese Academy of Medical Sciences & Peking Union Medical College, State Key Laboratory of Cardiovascular Diseases, Beijing, China.
authors.forename: Wenting
authors.initials: W
authors.lastname: Su
authors.forename: Tao
authors.initials: T
authors.lastname: An
authors.forename: Qiong
authors.initials: Q
authors.lastname: Zhou
authors.forename: Yan
authors.initials: Y
authors.lastname: Huang
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
authors.forename: Yuhui
authors.initials: Y
authors.lastname: Zhang
authors.forename: Bingqi
authors.initials: B
authors.lastname: Wei
authors.forename: Xiaolu
authors.initials: X
authors.lastname: Sun
authors.forename: Changhong
authors.initials: C
authors.lastname: Zou
authors.forename: Kejia
authors.initials: K
authors.lastname: Lou
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D015415:Biomarkers / Q000097:blood; D015331:Cohort Studies; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000175:diagnosis; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D020097:Natriuretic Peptide, Brain / Q000032:analysis*; D010446:Peptide Fragments / Q000032:analysis*; D011379:Prognosis; D016016:Proportional Hazards Models; D012307:Risk Factors; D012709:Serum Albumin / Q000032:analysis*
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; D012709:Serum Albumin; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain