title: Capucin does not modify the toxicity of a mutant Huntingtin fragment in vivo.
abstract: Genes selectively expressed in the striatum may be involved in the preferential vulnerability of striatal neurons to Huntington's disease (HD). Here, we investigated whether perturbations of Capucin expression, which is enriched in the striatum and downregulated in Huntington's disease models, could modify the neurotoxicity induced by the injection of a lentiviral vector encoding a short N-terminal fragment of mutant Huntingtin (mHtt) into the mouse striatum. Neither constitutive Capucin deficiency in knockout mice nor lentiviral vector-mediated Capucin overexpression in the striatum of adult wild type mice significantly modified vulnerability to the mHtt fragment in vivo, suggesting that Capucin has no impact on mHtt toxicity.
authors.affiliation: CEA, DSV, I2BM, Molecular Imaging Research Center, Fontenay-aux-Roses, France.
authors.forename: Laurie
authors.initials: L
authors.lastname: Galvan
authors.forename: Nad'a
authors.initials: N
authors.lastname: Lepejová
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Gaillard
authors.forename: Carole
authors.initials: C
authors.lastname: Malgorn
authors.forename: Martine
authors.initials: M
authors.lastname: Guillermier
authors.forename: Diane
authors.initials: D
authors.lastname: Houitte
authors.forename: Gilles
authors.initials: G
authors.lastname: Bonvento
authors.forename: Fanny
authors.initials: F
authors.lastname: Petit
authors.forename: Noëlle
authors.initials: N
authors.lastname: Dufour
authors.forename: Patrick
authors.initials: P
authors.lastname: Héry
authors.forename: Matthieu
authors.initials: M
authors.lastname: Gérard
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Elalouf
authors.forename: Nicole
authors.initials: N
authors.lastname: Déglon
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Brouillet
authors.forename: Michel
authors.initials: M
authors.lastname: de Chaldée
mesh_terms: D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism* / Q000473:pathology*; D000071058:Huntingtin Protein; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D009154:Mutation; D009419:Nerve Tissue Proteins / Q000235:genetics* / Q000378:metabolism*; D009687:Nuclear Proteins / Q000235:genetics* / Q000378:metabolism*
chemical_list: C506812:Htt protein, mouse; D000071058:Huntingtin Protein; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins; C511357:Syndig1l protein, mouse