title: Salamanders and fish can regenerate lost structures--why can't we?
abstract: The recent introduction of in vivo lineage-tracing techniques using fluorescently labeled cells challenged the long-standing view that complete dedifferentiation is a major force driving vertebrate tissue regeneration. The report in BMC Developmental Biology by Juan Carlos Izpisúa Belmonte and colleagues adds a new twist to a rapidly evolving view of the origin of blastemal cells. As classic and recent experimental findings are considered together, a new perspective on vertebrate muscle regeneration is emerging.See research article http://www.biomedcentral.com/1471-213X/12/9.
authors.affiliation: Department of Pediatrics, Northwestern University, The Feinberg School of Medicine, Children's Memorial Research Center, 2300 Children's Plaza, Chicago, IL 60614, USA. hgsimon@northwestern.edu
authors.forename: Hans-Georg
authors.initials: HG
authors.lastname: Simon
mesh_terms: D000663:Amphibians / Q000196:embryology / Q000502:physiology; D000818:Animals; D005399:Fishes / Q000196:embryology / Q000502:physiology; D006801:Humans; D051379:Mice / Q000196:embryology / Q000502:physiology; D018482:Muscle, Skeletal / Q000502:physiology*; D012038:Regeneration; D013045:Species Specificity; D013234:Stem Cells / Q000378:metabolism / Q000502:physiology*; D014714:Vertebrates / Q000196:embryology / Q000502:physiology*