title: Salicylimine-based fluorescent chemosensor for aluminum ions and application to bioimaging.
abstract: In this study, an assay to quantify the presence of aluminum ions using a salicylimine-based receptor was developed utilizing turn-on fluorescence enhancement. Upon treatment with aluminum ions, the fluorescence of the sensor was enhanced at 510 nm due to formation of a 1:1 complex between the chemosensor and the aluminum ions at room temperature. As the concentration of Al(3+) was increased, the fluorescence gradually increased. Other metal ions, such as Na(+), Ag(+), K(+), Ca(2+), Mg(2+), Hg(2+), Mn(2+), Co(2+), Ni(2+), Cu(2+), Zn(2+), Cd(2+), Pb(2+), Cr(3+), Fe(3+), and In(3+), had no such significant effect on the fluorescence. In addition, we show that the probe could be used to map intracellular Al(3+) distribution in live cells by confocal microscopy.
authors.affiliation: Department of Chemistry and Nano Science, Ewha Womans University, Seoul, 120-750, Korea.
authors.forename: Soojin
authors.initials: S
authors.lastname: Kim
authors.forename: Jin Young
authors.initials: JY
authors.lastname: Noh
authors.forename: Ka Young
authors.initials: KY
authors.lastname: Kim
authors.forename: Jin Hoon
authors.initials: JH
authors.lastname: Kim
authors.forename: Hee Kyung
authors.initials: HK
authors.lastname: Kang
authors.forename: Seong-Won
authors.initials: SW
authors.lastname: Nam
authors.forename: So Hyun
authors.initials: SH
authors.lastname: Kim
authors.forename: Sungsu
authors.initials: S
authors.lastname: Park
authors.forename: Cheal
authors.initials: C
authors.lastname: Kim
authors.forename: Jinheung
authors.initials: J
authors.lastname: Kim
mesh_terms: D000535:Aluminum / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D007097:Imines / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D018613:Microscopy, Confocal; D020156:Salicylic Acid / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D005456:Fluorescent Dyes; D007097:Imines; D000535:Aluminum; D020156:Salicylic Acid