title: Perioperative antibiotic in adenoidectomy with partial tonsillectomy: a randomized trial.
abstract: OBJECTIVE
  To examine potential benefits of perioperative antibiotic therapy in children undergoing adenotonsillotomy.
  
  
  METHODS
  Adenoidectomy with tonsillotomy was performed in 124 children with obstructive symptoms, aged 5-7 years. Of these, 120 completed the study. Intraoperative intravenous and postoperative oral clindamycin, or placebo for 7 days, were administered.
  
  
  RESULTS
  There were significant differences between the groups regarding pain intensity (p < 0.001) and duration (p < 0.05), day of return to normal physical activity (p < 0.05), occurrence and duration of oral malodor (p < 0.001), number of doses of additional analgesic (p < 0.001), healing grading (p < 0.05) and parents'/caregivers' satisfaction scores on the 4th postoperative day. There were indications for antibiotic in 2 individuals in the placebo group.
  
  
  CONCLUSIONS
  There are significant differences in the course of convalescence related to perioperative antibiotic in children after adenotonsillotomy, but strict indications for antibiotics in these patients are rare.
authors.affiliation: ENT Department, St. John Grande's Hospital, Kraków, Poland. olafzag@gmail.com
authors.forename: Olaf
authors.initials: O
authors.lastname: Zagólski
authors.forename: Jan
authors.initials: J
authors.lastname: Kulisiewicz
mesh_terms: D000233:Adenoidectomy / Q000379:methods*; D000284:Administration, Oral; D000402:Airway Obstruction / Q000382:microbiology / Q000601:surgery; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001424:Bacterial Infections / Q000517:prevention & control; D002648:Child; D002675:Child, Preschool; D002981:Clindamycin / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007262:Infusions, Intravenous; D007432:Intraoperative Period; D008297:Male; D010149:Postoperative Pain / Q000517:prevention & control; D013530:Surgical Wound Infection / Q000517:prevention & control*; D014068:Tonsillectomy / Q000379:methods*; D014069:Tonsillitis / Q000382:microbiology / Q000601:surgery*
chemical_list: D000900:Anti-Bacterial Agents; D002981:Clindamycin