title: Regioselective heterohalogenation of 4-halo-anisoles via a series of sequential ortho-aluminations and electrophilic halogenations.
abstract: As the aluminate base [LiAl(TMP)(2)(iBu)(2)] 1 displays halogen tolerance towards substituted aromatics, 4-halo-anisoles have been ortho-aluminated and electrophilically quenched to form synthetically useful multi-heterohalogenated anisoles, with the Al intermediates along the route structurally defined.
authors.affiliation: WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, UK.
authors.forename: Ben
authors.initials: B
authors.lastname: Conway
authors.forename: Elaine
authors.initials: E
authors.lastname: Crosbie
authors.forename: Alan R
authors.initials: AR
authors.lastname: Kennedy
authors.forename: Robert E
authors.initials: RE
authors.lastname: Mulvey
authors.forename: Stuart D
authors.initials: SD
authors.lastname: Robertson