title: Protease signalling: the cutting edge.
abstract: Protease research has undergone a major expansion in the last decade, largely due to the extremely rapid development of new technologies, such as quantitative proteomics and in-vivo imaging, as well as an extensive use of in-vivo models. These have led to identification of physiological substrates and resulted in a paradigm shift from the concept of proteases as protein-degrading enzymes to proteases as key signalling molecules. However, we are still at the beginning of an understanding of protease signalling pathways. We have only identified a minor subset of true physiological substrates for a limited number of proteases, and their physiological regulation is still not well understood. Similarly, links with other signalling systems are not well established. Herein, we will highlight current challenges in protease research.
authors.affiliation: Department of Biochemistry and Molecular and Structural Biology, Jozef Stefan Institute, Ljubljana, Slovenia. boris.turk@ijs.si
authors.forename: Boris
authors.initials: B
authors.lastname: Turk
authors.forename: Dušan
authors.initials: D
authors.lastname: Turk
authors.forename: Vito
authors.initials: V
authors.lastname: Turk
mesh_terms: D000818:Animals; D006801:Humans; D051379:Mice; D010447:Peptide Hydrolases / Q000378:metabolism*; D059748:Proteolysis; D040901:Proteomics; D015398:Signal Transduction; D013379:Substrate Specificity
chemical_list: D010447:Peptide Hydrolases