title: [Toxicological sanitary characterization of silver nanoparticles introduced in gastrointestinal tract of rats].
abstract: Water suspensions of silver nanoparticles were introduced intragastrically to growing male Wistar rats daily for 28 days. There were studied animals mass gain, relative masses of viscera, intestinal barrier resistance against protein macromolecules, DNA oxidative damage, tissue non-protein thiol levels, first and second phase of xenobiotic detoxication system activity, lysosomal membranes stability in liver together with routine blood biochemical and hematological indices and caecal's microbiocenose state. The data testifying to possible toxic risks, connected with reaction of silver's nanoparticles is obtained.
authors.forename: A A
authors.initials: AA
authors.lastname: Shumakova
authors.forename: V V
authors.initials: VV
authors.lastname: Smirnova
authors.forename: O N
authors.initials: ON
authors.lastname: Tananova
authors.forename: Ē N
authors.initials: ĒN
authors.lastname: Trushina
authors.forename: L V
authors.initials: LV
authors.lastname: Kravchenko
authors.forename: I V
authors.initials: IV
authors.lastname: Aksenov
authors.forename: A V
authors.initials: AV
authors.lastname: Selifanov
authors.forename: S Kh
authors.initials: SKh
authors.lastname: Soto
authors.forename: G G
authors.initials: GG
authors.lastname: Kuznetsova
authors.forename: A V
authors.initials: AV
authors.lastname: Bulakhov
authors.forename: I V
authors.initials: IV
authors.lastname: Safenkova
authors.forename: I V
authors.initials: IV
authors.lastname: Gmoshinskiĭ
authors.forename: S A
authors.initials: SA
authors.lastname: Khotimchenko
mesh_terms: D000284:Administration, Oral; D000704:Analysis of Variance; D000818:Animals; D001772:Blood Cell Count; D001835:Body Weight / Q000187:drug effects; D002432:Cecum / Q000187:drug effects / Q000378:metabolism / Q000382:microbiology; D004249:DNA Damage / Q000187:drug effects; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects*; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism / Q000382:microbiology; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008111:Liver Function Tests / Q000379:methods; D008297:Male; D053768:Metal Nanoparticles / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D012834:Silver / Q000008:administration & dosage / Q000633:toxicity*; D012984:Software; D013438:Sulfhydryl Compounds / Q000378:metabolism; D036401:Toxicity Tests, Chronic
chemical_list: D013438:Sulfhydryl Compounds; D012834:Silver