title: Anti-angiogenic effect of α-mangostin.
abstract: Eleven known prenyl xanthones, isolated from the pericarp of Garcinia mangostana, were tested for their ability to inhibit the phosphorylation of kinase domain receptor (KDR) tyrosine kinase. α-Mangostin was found to inhibit phosphorylation of KDR. α-Mangostin also showed to inhibit phosphorylation of the Y1175 residue of KDR (10 μM). This is the first report that α-mangostin inhibited the phosphorylation of KDR tyrosine kinase and also the Y1175 residue of KDR. α-Mangostin also showed inhibitory effects on proliferation of human umbilical vein endothelial cells (HUVECs) (IC(50) 1.2 μM) and human umbilical artery endothelial cells (IC(50) 2.4 μM), as well as the migration (IC(50) 0.034 μM) and tubule formation (at the concentrations of 0.6 and 1.2 μM) of HUVECs. These results suggest that the inhibition of the phosphorylation of KDR tyrosine kinase is concerned in the anti-angiogenic activity of α-mangostin.
authors.affiliation: Department of Pharmacognosy and Phytochemistry, Meiji Pharmaceutical University, Tokyo, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Shiozaki
authors.forename: Miyuki
authors.initials: M
authors.lastname: Fukai
authors.forename: Elvira
authors.initials: E
authors.lastname: Hermawati
authors.forename: Lia Dewi
authors.initials: LD
authors.lastname: Juliawaty
authors.forename: Yana Maolana
authors.initials: YM
authors.lastname: Syah
authors.forename: Euis Holisotan
authors.initials: EH
authors.lastname: Hakim
authors.forename: Ploenthip
authors.initials: P
authors.lastname: Puthongking
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Suzuki
authors.forename: Kaoru
authors.initials: K
authors.lastname: Kinoshita
authors.forename: Kunio
authors.initials: K
authors.lastname: Takahashi
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Koyama
mesh_terms: D020533:Angiogenesis Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D029762:Garcinia mangostana / Q000737:chemistry; D010766:Phosphorylation / Q000187:drug effects; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism; D044004:Xanthones / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D020533:Angiogenesis Inhibitors; D044004:Xanthones; D020794:Receptor Protein-Tyrosine Kinases; C021053:mangostin