title: Seroreactivity to LGL leukemia-specific epitopes in aplastic anemia, myelodysplastic syndrome and paroxysmal nocturnal hemoglobinuria: results of a bone marrow failure consortium study.
abstract: Large granular lymphocyte (LGL) leukemia is characterized by clonal expansion of antigen-activated cytotoxic T cells (CTL). Patients frequently exhibit seroreactivity against a human T-cell leukemia virus (HTLV) epitope, BA21. Aplastic anemia, paroxysmal nocturnal hemoglobinuria and myelodysplastic syndrome are bone marrow failure diseases that can also be associated with similar aberrant CTL activation (LGL-BMF). We identified a BA21 peptide that was specifically reactive with LGL leukemia sera and found significantly elevated antibody reactivity against the same peptide in LGL-BMF sera. This finding of shared seroreactivity in LGL-BMF conditions and LGL leukemia suggests that these diseases might share a common pathogenesis.
authors.affiliation: Penn State Hershey Cancer Institute, Penn State Hershey College of Medicine, Hershey, PA, USA. snyland@hmc.psu.edu
authors.forename: Susan Bell
authors.initials: SB
authors.lastname: Nyland
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Krissinger
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Clemente
authors.forename: Rosalyn B
authors.initials: RB
authors.lastname: Irby
authors.forename: Kendall Thomas
authors.initials: KT
authors.lastname: Baab
authors.forename: Nancy Ruth
authors.initials: NR
authors.lastname: Jarbadan
authors.forename: Lubomir
authors.initials: L
authors.lastname: Sokol
authors.forename: Eric
authors.initials: E
authors.lastname: Schaefer
authors.forename: Jason
authors.initials: J
authors.lastname: Liao
authors.forename: David
authors.initials: D
authors.lastname: Cuthbertson
authors.forename: Pearlie
authors.initials: P
authors.lastname: Epling-Burnette
authors.forename: Ronald
authors.initials: R
authors.lastname: Paquette
authors.forename: Alan F
authors.initials: AF
authors.lastname: List
authors.forename: Jaroslaw P
authors.initials: JP
authors.lastname: Maciejewski
authors.forename: Thomas P
authors.initials: TP
authors.lastname: Loughran
mesh_terms: D000595:Amino Acid Sequence; D000741:Anemia, Aplastic / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D018985:Epitopes, B-Lymphocyte; D006457:Hemoglobinuria, Paroxysmal / Q000276:immunology*; D006801:Humans; D054066:Leukemia, Large Granular Lymphocytic / Q000209:etiology / Q000276:immunology*; D008969:Molecular Sequence Data; D009190:Myelodysplastic Syndromes / Q000276:immunology*
chemical_list: D018985:Epitopes, B-Lymphocyte