title: [Effect of Tiangou Jiangya capsule on rabbit aortic strip contraction].
abstract: OBJECTIVE
  To observe the effect of Tiangou Jiangya capsule on isolated rabbit aortic strips, and to discuss its antihypertensive mechanism.
  
  
  METHODS
  The isolated rabbit aortic strips were placed in perfusion baths, and induced to contract by norepinephrine (NE), KCl and CaCl2 respectively, then Tiangou Jiangya capsule extraction was added to observe its effect on the contraction. The effect on intracellular Ca2+ dependent contraction and extracellular Ca2+ dependent contraction induced by NE were also studied.
  
  
  RESULTS
  The Tiangou Jiangya capsule (1, 3, 5 g x L(-1)) can reduce the largest contract reaction of aortic strips induced by NE or CaCl2 (P < 0.01). It can reduce both intracellular Ca2+ dependent contraction and extracellular Ca2+ dependent contraction induced by NE (P < 0.01), and the effect on extracellular Ca2+ dependent contraction is more significant. But the Tiangou Jiangya capsule has no significant effect on KCl induced contraction.
  
  
  CONCLUSIONS
  Tiangou Jiangya capsule can regulate intracellular Ca2+ concentration and help to relax the vascular smooth muscle. The mechanism could be regulating the receptor-operated Ca2+ channel. The effect on extracellular Ca2+ dependent contraction is more obvious than on intracellular Ca2+ dependent contraction induced by NE.
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Yang
authors.forename: Yujie
authors.initials: Y
authors.lastname: Li
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Weng
authors.forename: Ying
authors.initials: Y
authors.lastname: Chen
authors.forename: Congxiao
authors.initials: C
authors.lastname: Ruan
authors.forename: Xiaoxin
authors.initials: X
authors.lastname: Zhu
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001011:Aorta / Q000187:drug effects; D001592:Benzyl Alcohols / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002122:Calcium Chloride / Q000494:pharmacology*; D004231:Diuresis / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005419:Flavonoids / Q000494:pharmacology*; D005663:Furans / Q000494:pharmacology*; D005960:Glucosides / Q000494:pharmacology*; D066298:In Vitro Techniques; D017705:Lignans / Q000494:pharmacology*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology; D011817:Rabbits; D012084:Renin-Angiotensin System / Q000187:drug effects; D016277:Ventricular Function, Left / Q000187:drug effects
chemical_list: D000959:Antihypertensive Agents; D001592:Benzyl Alcohols; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D005663:Furans; D005960:Glucosides; D017705:Lignans; C560376:Tiangou; D011189:Potassium Chloride; D002122:Calcium Chloride; D009638:Norepinephrine