title: Relationship between normal serum creatinine concentration and periodontal disease in Japanese middle-aged males.
abstract: BACKGROUND
  Periodontitis has been shown to be closely related to diabetes, which was recently found to be associated with lower serum creatinine. Conversely, several studies have suggested a positive relationship between periodontitis and abnormally high concentrations of serum creatinine associated with renal dysfunction, seemingly contradicting the above. This study evaluates periodontal status and serum levels of creatinine within the normal range to resolve this apparent contradiction.
  
  
  METHODS
  A comprehensive health examination of 907 Japanese males, 49 to 59 years old, was performed from 2000 to 2002. A blood sample was collected from the antecubital vein after an overnight fast. The periodontal parameters were periodontal probing depth (PD) and clinical attachment loss (AL). We examined the association between serum creatinine concentration within the normal range and periodontal parameters.
  
  
  RESULTS
  Serum creatinine concentration within the normal range was inversely correlated with mean PD and mean AL. In multivariate linear regression analyses, every 0.1-mg/dL increment in serum creatinine concentration was associated with a 0.064-mm decrease in both mean PD and mean AL (P <0.05) after adjusting for confounding variables.
  
  
  CONCLUSIONS
  This study finds a significant inverse association between normal serum creatinine concentration and periodontal disease.
authors.affiliation: Section of Preventive and Public Health Dentistry, Division of Oral Health, Growth, and Development, Kyushu University Faculty of Dental Science, Higashi-ku, Fukuoka, Japan. shima@dent.kyushu-u.ac.jp
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Shimazaki
authors.forename: Mitoshi
authors.initials: M
authors.lastname: Kushiyama
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Murakami
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Yamashita
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood; D003404:Creatinine / Q000097:blood*; D006801:Humans; D007564:Japan; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000097:blood / Q000145:classification; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000097:blood / Q000145:classification; D010518:Periodontitis / Q000097:blood*; D057566:Self Report; D012907:Smoking; D016388:Tooth Loss / Q000145:classification; D014099:Toothbrushing / Q000706:statistics & numerical data
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D008055:Lipids; D003404:Creatinine