title: [Lipids of neocortex after X-ray irradiation of the rat head at a dose of 200 Gy].
abstract: X-ray irradiation at a dose of 200 Gy with local exposure of the rat head induced the change of the lipid content in the neocortex tissue. The amount of phosphatidylinositol was decreased, the amount of free fatty acids, diglycerols, sphingomyelin was increased, and the amount of cholesterol had a growth trend in 2 h after X-ray exposition. The results testify in favor of participation of phosphatidylinositol- and sphingomyelin-relating signal systems and cholesterol in early stages of the cerebral radiation syndrome. We suggest that the change of the lipid content in early periods after the effect of a super-high dose of X-ray irradiation indicates the lipid dependence in the elimination of motion damages and the restoration of the functions of nerve cells. Effects on the lipid metabolism in the nerve tissue are promising for correcting the cerebral radiation syndrome.
authors.forename: L N
authors.initials: LN
authors.lastname: Markevich
authors.forename: I K
authors.initials: IK
authors.lastname: Kolomiĭtseva
authors.forename: O V
authors.initials: OV
authors.lastname: Bykova
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000378:metabolism*; D005230:Fatty Acids, Nonesterified / Q000378:metabolism*; D006257:Head / Q000528:radiation effects; D050356:Lipid Metabolism / Q000528:radiation effects; D008297:Male; D020714:Maximum Tolerated Dose; D019579:Neocortex / Q000528:radiation effects*; D009474:Neurons / Q000378:metabolism / Q000528:radiation effects; D010716:Phosphatidylinositols / Q000378:metabolism*; D011839:Radiation, Ionizing; D051381:Rats; D017208:Rats, Wistar; D013109:Sphingomyelins / Q000378:metabolism*
chemical_list: D005230:Fatty Acids, Nonesterified; D010716:Phosphatidylinositols; D013109:Sphingomyelins; D002784:Cholesterol