title: Identification of miR-508-3p and miR-509-3p that are associated with cell invasion and migration and involved in the apoptosis of renal cell carcinoma.
abstract: MicroRNAs (miRNAs) have emerged as powerful regulators of multiple processes linked to human cancer, including cell apoptosis, proliferation and migration, suggesting that the regulation of miRNA function could play a critical role in cancer progression. Recent studies have found that human serum/plasma contains stably expressed miRNAs. If they prove indicative of disease states, miRNAs measured from peripheral blood samples may be a source for routine clinical detection of cancer. Our studies showed that both miR-508-3p and miR-509-3p were down-regulated in renal cancer tissues. The level of miR-508-3p but not miR-509-3p in renal cell carcinoma (RCC) patient plasma demonstrated significant differences from that in control plasma. In addition, the overexpression of miR-508-3p and miR-509-3p suppressed the proliferation of RCC cells (786-0), induced cell apoptosis and inhibited cell migration in vitro. Our data demonstrated that miR-508-3p and miR-509-3p played an important role as tumor suppressor genes during tumor formation and that they may serve as novel diagnostic markers for RCC.
authors.affiliation: Department of Clinical Laboratory, Peking University Shenzhen Hospital, Guangdong, China.
authors.forename: Qingna
authors.initials: Q
authors.lastname: Zhai
authors.forename: Liang
authors.initials: L
authors.lastname: Zhou
authors.forename: Chunjuan
authors.initials: C
authors.lastname: Zhao
authors.forename: Jun
authors.initials: J
authors.lastname: Wan
authors.forename: Zhendong
authors.initials: Z
authors.lastname: Yu
authors.forename: Xin
authors.initials: X
authors.lastname: Guo
authors.forename: Jie
authors.initials: J
authors.lastname: Qin
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.forename: Ruijing
authors.initials: R
authors.lastname: Lu
mesh_terms: D000293:Adolescent; D000328:Adult; D017209:Apoptosis; D002292:Carcinoma, Renal Cell / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D002465:Cell Movement; D049109:Cell Proliferation; D002648:Child; D002675:Child, Preschool; D015536:Down-Regulation; D005260:Female; D016147:Genes, Tumor Suppressor; D006801:Humans; D007223:Infant; D007680:Kidney Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D008297:Male; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D014407:Tumor Cells, Cultured; D055815:Young Adult
chemical_list: C571981:MIRN508 microRNA, human; C571982:MIRN509 microRNA, human; D035683:MicroRNAs