title: [Early onset of anti- erythropoietin antibody-mediated pure red cell aplasia after commencement of subcutaneous administration of epoetin-β].
abstract: We report a 73-year-old Japanese man with early onset pure red cell aplasia (PRCA) caused by subcutaneous administration of recombinant epoetin-β. Two months after the start of epoetin therapy, he developed PRCA. Anti-erythropoietin (EPO) antibody, detected in the patient's serum by enzyme immunoassay and radioimmunoprecipitation method, inhibited EPO-dependent growth of AS-E2 cells in vitro. Treatment with prednisone (1 mg/kg) significantly reduced antibody levels 3 months later. It is important to have an awareness of antibody-mediated PRCA. Our case shows that subcutaneous epoetin administration produces this complication in the early period of therapy.
authors.affiliation: Internal Medicine, Kyusyu Rosai Hospital.
authors.forename: Aya
authors.initials: A
authors.lastname: Tanaka
authors.forename: Junichi
authors.initials: J
authors.lastname: Tsukada
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Morimoto
authors.forename: Takefumi
authors.initials: T
authors.lastname: Katsuragi
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Nakanishi
authors.forename: Shu
authors.initials: S
authors.lastname: Watanabe
authors.forename: Nobuhisa
authors.initials: N
authors.lastname: Hirase
authors.forename: Seiichi
authors.initials: S
authors.lastname: Motomura
mesh_terms: D000368:Aged; D000740:Anemia / Q000188:drug therapy; D000906:Antibodies; D004921:Erythropoietin / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*; D006801:Humans; D007279:Injections, Subcutaneous; D008297:Male; D011239:Prednisolone / Q000008:administration & dosage; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology; D012010:Red-Cell Aplasia, Pure / Q000209:etiology* / Q000276:immunology / Q000628:therapy; D016896:Treatment Outcome
chemical_list: D000906:Antibodies; D011994:Recombinant Proteins; C103998:epoetin beta; D004921:Erythropoietin; D011239:Prednisolone