title: Potential impact of accelerating the primary dose of rotavirus vaccine in infants.
abstract: We estimated the potential impact of administering the first dose of rotavirus vaccine at 6 weeks (42 days of life) instead of 2 months of age, which is permissible for all U.S. vaccines recommended at 2 months of age, on rotavirus hospitalization rates. We used published data for hospitalization rates, vaccine coverage, and vaccine efficacy after one dose and assumed a two-week delay in seroconversion after vaccine administration in the United States. Administering the first dose of rotavirus vaccine at 6 weeks instead of 8 weeks of age should have prevented 1110, 1660, and 2210 rotavirus hospitalizations among U.S. infants <3 months of age in 2006 when the vaccine was first introduced. This estimated benefit represents a 2-4% reduction in rotavirus hospitalizations among children <5 years of age.
authors.affiliation: Department of Pediatrics, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.
authors.forename: Elizabeth E
authors.initials: EE
authors.lastname: Halvorson
authors.forename: Timothy R
authors.initials: TR
authors.lastname: Peters
authors.forename: Beverly M
authors.initials: BM
authors.lastname: Snively
authors.forename: Katherine A
authors.initials: KA
authors.lastname: Poehling
mesh_terms: D005759:Gastroenteritis / Q000276:immunology / Q000517:prevention & control; D006760:Hospitalization; D006801:Humans; D007115:Immunization Schedule; D007223:Infant; D012400:Rotavirus Infections / Q000276:immunology / Q000517:prevention & control*; D022243:Rotavirus Vaccines / Q000008:administration & dosage* / Q000276:immunology; D014481:United States
chemical_list: D022243:Rotavirus Vaccines