title: The potential of interleukin-17 to mediate hematopoietic response.
abstract: It has long been known that T cells have the potential to modulate hematopoietic response in different ways. More recently, the importance of interleukin (IL)-17-secreting Th17 cells in T-cell-mediated regulation of hematopoiesis was indicated by the line of evidence that IL-17 links T-cell function and hematopoiesis through stimulation of granulopoiesis and neutrophil trafficking. Furthermore, our data demonstrated that IL-17 also affects other cells of hematopoietic system, such as erythroid progenitors, as well as mesenchymal stem cells. In order to better understand the regulatory role of IL-17 in hematopoiesis, molecular mechanisms underlying the effects of IL-17 on hematopoietic and mesenchymal stem cells were also studied.
authors.affiliation: Laboratory for Experimental Hematology and Stem Cells, Institute for Medical Research, University of Belgrade, Dr Subotica 4, PO Box 102, 11129 Belgrade, Beograd, Serbia.
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Krstic
authors.forename: Slavko
authors.initials: S
authors.lastname: Mojsilovic
authors.forename: Gordana
authors.initials: G
authors.lastname: Jovcic
authors.forename: Diana
authors.initials: D
authors.lastname: Bugarski
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000502:physiology; D006413:Hematopoietic System / Q000378:metabolism*; D006801:Humans; D020381:Interleukin-17 / Q000276:immunology*; D059630:Mesenchymal Stem Cells / Q000378:metabolism; D009504:Neutrophils / Q000378:metabolism; D058504:Th17 Cells / Q000276:immunology* / Q000378:metabolism
chemical_list: D020381:Interleukin-17