title: Safety and Efficacy of Thrombolytic Therapy Using rt-PA (Alteplase) in Acute Ischemic Stroke.
abstract: The aim of this study was to evaluate the efficacy and safety of thrombolytic therapy. Our study enrolled 23 patients out of which 2 patients died due to ICH; we also found that only 39% of patients reached hospital within stroke window, and for those treated, mean NIHSS during admission was 14.0, but drastic improvement was shown after 24 hours of treatment, that is, 9.89 (P < 0.0001), and at discharge, it was 5.1 (P < 0.0001) which showed a clear impact of the treatment, and around 60% of patients were discharged within an mRS score of 1 and 2. Hence, it was found that thrombolytic therapy was beneficial, efficacious, and safe if used within 3 to 4.5 hours.
authors.affiliation: Department of Pharmacy Practice, KMCH College of Pharmacy, Kovai Estate, Kalapatti Road, Coimbatore, Tamilnadu 48, India.
authors.forename: Palanisamy
authors.initials: P
authors.lastname: Sivanandy
authors.forename: Binny
authors.initials: B
authors.lastname: Thomas
authors.forename: Vijayan
authors.initials: V
authors.lastname: Krishnan
authors.forename: Sumathy
authors.initials: S
authors.lastname: Arunachalam