title: [Pharmacokinetics study of compound xueshuantong soft capsules].
abstract: OBJECTIVE
  To establish a RP-HPLC method for determination of the content of ginsenoside Rg1 in the rabbits aqueous humor, blood and ocular tissues, which were given intragastric administration with the co-xueshuantong soft capsules. The drug concentration in rabbits at different times after oral administration has been determined and the pharmacokinetics characteristics has been researched.
  
  
  METHODS
  The compound xueshuantong soft capsules were administrated to the healthy New Zealand rabbits by gavage (10 mg x kg(-1) per rabbit). The concentration of Ginseng Rg1 in aqueous humor, blood and ocular tissues at different time was determined by RP-HPLC.
  
  
  RESULTS
  RP-HPLC can be established for the determination of ginsenoside Rg1 in the rabbits aqueous humor, blood, ocular tissue. The calibration of curves was linear within the range of 7.60-152.0 mg x L(-1) (r = 0.999 6) for ginsenoside Rg1 in aqueous humor and the calibration of curves were linear within the range of 10.35-103, 50 mg x L(-1) (r = 0.999 8) for ginsenoside Rg1 in blood. Determination of the recovery rate to meet the requirements.
  
  
  CONCLUSIONS
  The ginsenosides Rg1 could transmit the blood-ocular barrier into the eyes and reach a certain concentration. The research provides a theoretical and experimental basis for the systemic administration of compound Xueshuantong to treat eye diseases.
authors.affiliation: Changchun Traditional Medicine University, Changchun 130117, China. chaoying_li@126.com
authors.forename: Chaoying
authors.initials: C
authors.lastname: Li
authors.forename: Bo
authors.initials: B
authors.lastname: Sun
authors.forename: Jingfang
authors.initials: J
authors.lastname: Chen
authors.forename: Yanping
authors.initials: Y
authors.lastname: Miao
authors.forename: Yi
authors.initials: Y
authors.lastname: Che
mesh_terms: D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism; D002138:Calibration; D002214:Capsules; D002851:Chromatography, High Pressure Liquid; D004365:Drugs, Chinese Herbal / Q000493:pharmacokinetics*; D005260:Female; D036145:Ginsenosides / Q000493:pharmacokinetics*; D008297:Male; D011817:Rabbits
chemical_list: D002214:Capsules; D004365:Drugs, Chinese Herbal; D036145:Ginsenosides; C035054:ginsenoside Rg1