title: Association of polymorphisms of STAT6 and SO(2) with Chinese childhood asthma: a case-control study.
abstract: OBJECTIVE
  To investigate the association of polymorphisms of STAT6 gene and air pollutants of PM(10), NO(2), and SO(2), with asthma in Chinese children.
  
  
  METHODS
  418 subjects aged 14 years and under were recruited in a case-control study. The association between STAT6 polymorphisms and childhood asthma were tested by allele frequency, genotype analysis, and MDR analysis. Exposure to outdoor air pollutants was estimated by a 5-day moving average level. Statistical analyses were performed with SAS 9.1 software.
  
  
  RESULTS
  Only 3 alleles of GT repeats at exon 1 of STAT6 were found in Chinese children. C258T and T710C were 2 new SNPs of STAT6 at 3'-UTR. Children who carried T allele of C258T were more common in asthma children than in control subjects (P<0.05). The MDR analysis showed that GT repeats, C258T and T710C of STAT6 polymorphisms interacted together in leading to susceptibility to childhood asthma among Chinese people. After confounding factors were controlled, such as SNP C258T, family history of asthma, frequency of influenza within a year, the 5-day average of SO(2) was tested to be a key risk factor of asthma in Chinese children (P<0.05).
  
  
  CONCLUSIONS
  Chinese children differed in polymorphisms of STAT6 and in its relation with childhood asthma.
authors.affiliation: Institute of Environmental Health and Related Product Safety, Chinese Centre for Disease Control and Prevention, Beijing 100050, China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wang
authors.forename: Xue Tao
authors.initials: XT
authors.lastname: Bai
authors.forename: Dong Qun
authors.initials: DQ
authors.lastname: Xu
authors.forename: Hong
authors.initials: H
authors.lastname: Li
authors.forename: Chun Yu
authors.initials: CY
authors.lastname: Xu
authors.forename: Jian Long
authors.initials: JL
authors.lastname: Fang
mesh_terms: D000293:Adolescent; D000393:Air Pollutants / Q000633:toxicity*; D044466:Asian People / Q000235:genetics; D001249:Asthma / Q000139:chemically induced / Q000453:epidemiology / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D018900:Dinucleotide Repeats; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide; D050800:STAT6 Transcription Factor / Q000235:genetics*; D013458:Sulfur Dioxide / Q000633:toxicity*
chemical_list: D000393:Air Pollutants; D050800:STAT6 Transcription Factor; C494101:STAT6 protein, human; D013458:Sulfur Dioxide