title: Light-activated nanotube-porphyrin conjugates as effective antiviral agents.
abstract: Porphyrins have been used for photodynamic therapy (PDT) against a wide range of targets like bacteria, viruses and tumor cells. In this work, we report porphyrin-conjugated multi-walled carbon nanotubes (NT-P) as potent antiviral agents. Specifically, we used Protoporphyrin IX (PPIX), which we attached to acid-functionalized multi-walled carbon nanotubes (MWNTs). We decided to use carbon nanotubes as scaffolds because of their ease of recovery from a solution through filtration. In the presence of visible light, NT-P was found to significantly reduce the ability of Influenza A virus to infect mammalian cells. NT-P may be used effectively against influenza viruses with little or no chance of them developing resistance to the treatment. Furthermore, NT-P can be easily recovered through filtration which offers a facile strategy to reuse the active porphyrin moiety to its fullest extent. Thus NT-P conjugates represent a new approach for preparing ex vivo reusable antiviral agents.
authors.affiliation: Howard P Isermann Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, 110 8th Street, Troy, NY 12180, USA.
authors.forename: Indrani
authors.initials: I
authors.lastname: Banerjee
authors.forename: Marc P
authors.initials: MP
authors.lastname: Douaisi
authors.forename: Dhananjoy
authors.initials: D
authors.lastname: Mondal
authors.forename: Ravi S
authors.initials: RS
authors.lastname: Kane
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology* / Q000528:radiation effects*; D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D009980:Influenza A virus / Q000187:drug effects / Q000472:pathogenicity; D008027:Light; D037742:Nanotubes, Carbon / Q000737:chemistry* / Q000528:radiation effects*; D038761:Photobleaching; D055668:Photochemical Processes; D017319:Photosensitizing Agents / Q000737:chemistry / Q000494:pharmacology / Q000528:radiation effects; D011524:Protoporphyrins / Q000737:chemistry / Q000494:pharmacology / Q000528:radiation effects; D018406:Virus Physiological Phenomena / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D037742:Nanotubes, Carbon; D017319:Photosensitizing Agents; D011524:Protoporphyrins; C028025:protoporphyrin IX