title: Effects of polyunsaturated fatty acids on cocaine-conditioned place preference in mice.
abstract: OBJECTIVE
  The objective of the present study was to assess whether the administration of polyunsaturated fatty acids (PUFAs) would lead to alterations in cocaine-conditioned place preference by correlating behavioral data and plasma levels of PUFAs.
  
  
  METHODS
  Five groups of C57Bl/6J mice received a linseed oil supplement or a control solution for 19 days and were conditioned to cocaine.
  
  
  RESULTS
  PUFAs did not exert a protective effect against cocaine-conditioned place-preference behavior, although there were significant differences  in the levels of eicosapentaenoic acid (EPA) and linoleic acid among the groups tested. Higher doses of PUFAs might be necessary to induce a change in the plasma level of EPA in cocaine-conditioned mice.
  
  
  CONCLUSIONS
  PUFAs had no effect on cocaine-conditioned place preference.
authors.affiliation: Universidade Federal de São Paulo, São Paulo, SP, Brazil.
authors.forename: Jaqueline Kalleian
authors.initials: JK
authors.lastname: Eserian
authors.forename: Vânia
authors.initials: V
authors.lastname: D'Almeida
authors.forename: Monica Levy
authors.initials: ML
authors.lastname: Andersen
authors.forename: José Carlos Fernandes
authors.initials: JC
authors.lastname: Galduróz
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003042:Cocaine / Q000008:administration & dosage; D003213:Conditioning, Psychological / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D015118:Eicosapentaenoic Acid / Q000097:blood; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage* / Q000097:blood; D019787:Linoleic Acid / Q000097:blood; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL
chemical_list: D005231:Fatty Acids, Unsaturated; D019787:Linoleic Acid; D015118:Eicosapentaenoic Acid; D003042:Cocaine