title: Squamous metaplasia in the cyst epithelium of type 1 congenital pulmonary airway malformation after thoracoamniotic shunt placement.
abstract: Thoracoamniotic shunting is the treatment of choice for management of the fetus with type 1 congenital pulmonary airway malformation. Thoracoamniotic shunting has been performed to reduce life-threatening risks such as fetal hydrops. However, caution is needed because of possible complications. Here, we report that thoracoamniotic shunting can cause histologic changes in the cyst epithelia. In 5 of 8 patients treated prenatally with thoracoamniotic shunting, squamous metaplasia in the cyst epithelia was seen; whereas squamous metaplasia was not found in 6 patients who were not treated with this procedure. Our results reveal that long-term exposure to the intrauterine environment could possibly lead to the change in the nature of cyst epithelium and consequent squamous metaplasia.
authors.affiliation: Department of Pathology, National Center for Child Health and Development, Tokyo 157-8535, Japan. matsuoka-k@ncchd.go.jp
authors.forename: Kentaro
authors.initials: K
authors.lastname: Matsuoka
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hayashi
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Urano
authors.forename: Lihua J
authors.initials: LJ
authors.lastname: Zhu
authors.forename: Hajime
authors.initials: H
authors.lastname: Okita
authors.forename: Haruhiko
authors.initials: H
authors.lastname: Sago
authors.forename: Atsuko
authors.initials: A
authors.lastname: Nakazawa
mesh_terms: D015615:Cystic Adenomatoid Malformation of Lung, Congenital / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D015160:Hydrops Fetalis / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D008297:Male; D008679:Metaplasia; D011247:Pregnancy; D016216:Ultrasonography, Prenatal