title: The role of PGC-1 and Apoε4 in insomnia.
abstract: OBJECTIVE
  Insomnia is associated with certain psychiatric illnesses such as anxiety disorder and depressive disorder. Moreover, sleep is controlled by endogenous circadian genes, which are associated with peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α). In addition, apolipoprotein ε4 (Apoε4), which plays an important role in lipid metabolism, may be also associated with some mental disorders related to insomnia. The aim of this study was to investigate the role of PGC-1α in insomnia among different mental disorder groups under the control of Apoε4 and other psychosocial factors.
  
  
  METHODS
  A total of 202 patients with insomnia and 253 controls were recruited.
  
  
  RESULTS
  Logistic regression and structural equation modeling showed similar results in that with sex and age controlled, major depressive disorder, PGC-1α and Apoε4 increased the risk of insomnia. With the factors of sex, age, major depressive disorder, and Apoε4 controlled, PGC-1α still increased the risk for insomnia, showing that the GG allele of PGC-1α may play an important role in insomnia.
  
  
  CONCLUSIONS
  In the future, when treating those with insomnia and high lipid profiles, health education with regard to how to control their lipid profile maybe used.
authors.affiliation: Department of Psychiatry, Zuoying Armed Forces General Hospital, Kaohsiung, Taiwan.
authors.forename: Chien-Chuan
authors.initials: CC
authors.lastname: Wang
authors.forename: For-Wey
authors.initials: FW
authors.lastname: Lung
mesh_terms: D053327:Apolipoprotein E4 / Q000235:genetics / Q000502:physiology*; D001483:Base Sequence; D017931:DNA Primers; D005260:Female; D006360:Heat-Shock Proteins / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008297:Male; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D016133:Polymerase Chain Reaction; D007319:Sleep Initiation and Maintenance Disorders / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*
chemical_list: D053327:Apolipoprotein E4; D017931:DNA Primers; D006360:Heat-Shock Proteins; C486497:PPARGC1A protein, human; D000071248:Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; D014157:Transcription Factors