title: [Prognostic value of PET using 11C-methionine in patients with untreated cerebral gliomas].
abstract: We evaluated the prognostic role of positron emission tomography (PET) with 11C-methionine in adults with untreated supratentorial glioma. Histopathologic grading and clinical follow-up data were available from 147 patients with low-grade (n=74) and high-grade gliomas (n=73). Follow-up was conducted until the last clinical contact (n=79) or until death (n=68). The 11C-methionine uptake index (UI) was calculated as the tumor hot spot-to-normal cortex uptake ratio. In the univariate analysis the statistical support from clinical, histological, and PET parameters was estimated using Kaplan-Meier method and log-rank test. For all glioma patients age (<40 or > or = 40 years), astrocytoma histopathology and WHO grading class (low versus high), extent of the increased 11C-methionine uptake (<6 cm or > or = 6), were found to be significant predictors of survival by univariate analysis. For all grades of gliomas UI higher than 2.0 was statistically associated with a shorter survival (p=0.00001). Patient sex, glioma location, pattern of the 11C-methionine uptake were not significantly predictive. In the most patients UI was closely associated with glioma histopathology. However separate analysis of astrocytoma subgroups showed that PET with "C-methionine was a more reliable prognostic factor in case of conflict between metabolic characteristic and histopathology findings. A high uptake of 11C-methionine and large extent of increased 11C-methionine accumulation were statistically associated with a poor survival time. Results showed that PET with 11C-methionine may be useful for determinating the prognosis of patients with primary glioma and this information can provide aid in making treatment decision.
authors.forename: T Iu
authors.initials: TIu
authors.lastname: Svortsova
authors.forename: Z L
authors.initials: ZL
authors.lastname: Brodskaia
authors.forename: A F
authors.initials: AF
authors.lastname: Gurchin
authors.forename: K P
authors.initials: KP
authors.lastname: Gaĭdaenko
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001254:Astrocytoma / Q000175:diagnosis* / Q000401:mortality* / Q000628:therapy; D002250:Carbon Radioisotopes / Q000008:administration & dosage; D002531:Cerebellum / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008715:Methionine / Q000008:administration & dosage*; D008875:Middle Aged; D049268:Positron-Emission Tomography; D011379:Prognosis; D011849:Radioactive Tracers; D011859:Radiography; D012737:Sex Factors; D015173:Supratentorial Neoplasms / Q000175:diagnosis* / Q000401:mortality* / Q000628:therapy; D015996:Survival Rate
chemical_list: D002250:Carbon Radioisotopes; D011849:Radioactive Tracers; D008715:Methionine