title: Novel therapeutic approaches to post-infarction remodelling.
abstract: Adverse cardiac remodelling is a major cause of morbidity and mortality following acute myocardial infarction (MI). Mechanical and neurohumoral factors involved in structural and molecular post-infarction remodelling were important targets in research and treatment for years. More recently, therapeutic strategies that address myocardial regeneration and pathophysiological mechanisms of infarct wound healing appear to be useful novel tools to prevent progressive ventricular dilation, functional deterioration, life-threatening arrhythmia, and heart failure. This review provides an overview of future and emerging therapies for cardiac wound healing and remodelling after MI.
authors.affiliation: Klinik fuer Kardiologie und Angiologie, Medizinische Hochschule Hannover, Hannover, Germany.
authors.forename: Daniela
authors.initials: D
authors.lastname: Fraccarollo
authors.forename: Paolo
authors.initials: P
authors.lastname: Galuppo
authors.forename: Johann
authors.initials: J
authors.lastname: Bauersachs
mesh_terms: D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D035683:MicroRNAs / Q000627:therapeutic use*; D009203:Myocardial Infarction / Q000150:complications* / Q000188:drug therapy; D017202:Myocardial Ischemia / Q000188:drug therapy / Q000628:therapy*; D033581:Stem Cell Transplantation / Q000379:methods*; D020257:Ventricular Remodeling / Q000187:drug effects* / Q000502:physiology
chemical_list: D035683:MicroRNAs