title: Effect of low-level laser therapy on healing of tenotomized Achilles tendon in streptozotocin-induced diabetic rats.
abstract: Diabetes mellitus (DM) is associated with musculoskeletal damage. Investigations have indicated that healing of the surgically tenotomized Achilles tendon was considerably augmented following low-level laser therapy (LLLT) in non-diabetic, healthy animals. The aim of the present study was to evaluate the effect of LLLT on the Achilles tendon healing in streptozotocin-induced diabetic (STZ-D) rats via a biomechanical evaluating method. Thirty-three rats were divided into non-diabetic (n = 18) and diabetic (n = 15) groups. DM was induced in the rats by injections of STZ. The right Achilles tendons of all rats were tenotomized 1 month after STZ injections. The two experimental groups (n = 6 for each group) of non-diabetic rats were irradiated with a helium-neon (He-Ne) laser at 2.9 and 11.5 J/cm(2) for ten consecutive days. The two experimental groups of diabetic rats (n = 5 for each group) were irradiated with a He-Ne laser at 2.9 and 4.3 J/cm(2) for ten consecutive days. The tendons were submitted to a tensiometric test. Significant improvements in the maximum stress (MS) values (Newton per square millimeter) were found following LLLT at 2.9 J/cm(2) in both the non-diabetic (p = 0.031) and diabetic (p = 0.019) experimental groups when compared with their control groups. LLLT at 2.9 J/cm(2) to the tenotomized Achilles tendons in the non-diabetic and diabetic rats significantly increased the strength and MS of repairing Achilles tendons in our study.
authors.affiliation: Department of Anatomical sciences and Biology, Medical Faculty, Shahid Beheshti University, MC, PO Box 19395/4719, Tehran, 1985717443, Iran. hamidrr2003@yahoo.com
authors.forename: Mohsen
authors.initials: M
authors.lastname: Nouruzian
authors.forename: Morteza
authors.initials: M
authors.lastname: Alidoust
authors.forename: Mohammad
authors.initials: M
authors.lastname: Bayat
authors.forename: Mehernoush
authors.initials: M
authors.lastname: Bayat
authors.forename: Mohammad
authors.initials: M
authors.lastname: Akbari
mesh_terms: D000125:Achilles Tendon / Q000293:injuries / Q000502:physiology / Q000528:radiation effects* / Q000601:surgery; D000818:Animals; D001696:Biomechanical Phenomena; D048909:Diabetes Complications / Q000503:physiopathology; D003921:Diabetes Mellitus, Experimental / Q000150:complications*; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D054020:Lasers, Gas; D028022:Low-Level Light Therapy / Q000295:instrumentation / Q000379:methods*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin; D058971:Tenotomy; D014945:Wound Healing / Q000528:radiation effects*
chemical_list: D013311:Streptozocin