title: Effect of azithromycin on small bowel motility in patients with gastrointestinal dysmotility.
abstract: OBJECTIVE
  To investigate the effect of azithromycin (AZI) on small bowel activity in patients with gastrointestinal dysmotility (GID).
  
  
  METHODS
  Manometric data on a consecutive series of 21 patients was reviewed. Only those patients with gastroparesis and small bowel dysmotility as defined by antroduodenal manometric criteria were included. Pressure profiles were recorded in three stages: baseline period, fed state and postprandial after administration of erythromycin (ERY) and AZI. The measured parameters included the number and characteristics of activity fronts and migrating motor complexes (MMCs) including duration, amplitude and frequency of contractions. The data were analyzed using repeated measures analysis of variance for comparison of each medication.
  
  
  RESULTS
  AZI induced more MMCs in the duodenum with origin of activity fronts in the antrum than did ERY (18 patients with AZI, 10 patients with ERY). No significant difference between AZI and ERY was seen with respect to the amplitude of MMCs or number of cycles per minute. The average duration of activity fronts was longer with AZI compared with ERY (AZI mean 18.5 min, ERY mean 9.7 min, p < 0.02).
  
  
  CONCLUSIONS
  AZI induces activity fronts in the antrum followed by duodenal contractions more frequently than ERY in patients with GID. AZI potentially promises to be a prokinetic for treatment of small bowel dysmotility.
authors.affiliation: Division of Gastroenterology, Hepatology, and Nutrition, University of Florida, Gainesville, FL 32608, USA. Payam.chini@medicine.ufl.edu
authors.forename: Payam
authors.initials: P
authors.lastname: Chini
authors.forename: Phillip P
authors.initials: PP
authors.lastname: Toskes
authors.forename: Shamaila
authors.initials: S
authors.lastname: Waseem
authors.forename: Wei
authors.initials: W
authors.lastname: Hou
authors.forename: Renee
authors.initials: R
authors.lastname: McDonald
authors.forename: Baharak
authors.initials: B
authors.lastname: Moshiree
mesh_terms: D000328:Adult; D000368:Aged; D017963:Azithromycin / Q000008:administration & dosage / Q000627:therapeutic use*; D004917:Erythromycin / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D005765:Gastrointestinal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D018589:Gastroparesis / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007421:Intestine, Small / Q000502:physiology*; D008297:Male; D008365:Manometry; D008875:Middle Aged; D016065:Myoelectric Complex, Migrating / Q000187:drug effects; D015282:Octreotide / Q000008:administration & dosage / Q000627:therapeutic use; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D005765:Gastrointestinal Agents; D004917:Erythromycin; D017963:Azithromycin; D015282:Octreotide