title: Pregnancy-associated plasma protein A (PAPP-A) and soluble receptor for advanced glycation end products (sRAGE)--intra- and inter-individual variability in chronic hemodialysis patients.
abstract: BACKGROUND
  Dialysis patients are at high risk of cardiovascular complications. Pregnancy-associated plasma protein A (PAPP-A) as well as sRAGE (soluble receptor for advanced glycation end products) are new biomarkers related to cardiovascular disease. The aim of our study was to describe their intra- and inter-individual variability.
  
  
  METHODS
  The studied group consisted of 21 chronic hemodialysis patients. PAPP-A, sRAGE and selected routine parameters were measured monthly during a 1-year prospective study.
  
  
  RESULTS
  Our results show high intra-individual variability of both PAPP-A and sRAGE. Both PAPP-A and sRAGE were closely linked to serum transferrin levels. Additionally, sRAGE was significantly associated with leukocyte count and haemoglobin.
  
  
  CONCLUSIONS
  Our study demonstrates high intra-individual variability of PAPP-A and sRAGE in stable clinical status. This finding could be helpful for further evaluation of the significance of PAPP-A and sRAGE in chronic kidney disease.
authors.affiliation: Institute of Medical Chemistry and Laboratory Diagnostics, 1st Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic.
authors.forename: Blanka
authors.initials: B
authors.lastname: Míková
authors.forename: Eva
authors.initials: E
authors.lastname: Jarolímková
authors.forename: Hana
authors.initials: H
authors.lastname: Benáková
authors.forename: Luděk
authors.initials: L
authors.lastname: Dohnal
authors.forename: Vladimír
authors.initials: V
authors.lastname: Tesař
authors.forename: Tomáš
authors.initials: T
authors.lastname: Zima
authors.forename: Marta
authors.initials: M
authors.lastname: Kalousová
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000150:complications / Q000628:therapy; D007958:Leukocyte Count; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011266:Pregnancy-Associated Plasma Protein-A / Q000378:metabolism*; D011446:Prospective Studies; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000097:blood*; D012044:Regression Analysis; D006435:Renal Dialysis; D014168:Transferrin / Q000378:metabolism
chemical_list: D015415:Biomarkers; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic; D014168:Transferrin; D011266:Pregnancy-Associated Plasma Protein-A