title: Identification of a novel adenovirus in a cotton-top tamarin (Saguinus oedipus).
abstract: A novel adenovirus was identified in a cotton-top tamarin (Saguinus oedipus) with diarrhea by negative-staining electron microscopy of feces, consensus polymerase chain reaction, and sequencing. Partial sequences were obtained from the DNA-dependent DNA polymerase, the p52k gene, and the hexon. Bayesian and maximum likelihood phylogenetic analyses indicated that the virus is a member of the genus Mastadenovirus, and is herein termed Saguinus siadenovirus 1. The phylogeny of the mastadenoviruses is similar to that of their hosts, supporting coevolution. Support for this was strongest in the analysis of the predicted hexon protein. The obtained sequences were GC-rich, which may suggest a lack of recent host jumps. The diversity and evolution of the adenoviruses of platyrrhine primates merits further investigation. Additional study of the association of this virus with diarrhea is indicated.
authors.affiliation: Department of Small Animal Clinical Sciences, University of Florida Veterinary Medical Center, Gainesville, FL, USA. halln@ufl.edu
authors.forename: Natalie H
authors.initials: NH
authors.lastname: Hall
authors.forename: Linda L
authors.initials: LL
authors.lastname: Archer
authors.forename: April L
authors.initials: AL
authors.lastname: Childress
authors.forename: James F X
authors.initials: JF
authors.lastname: Wellehan
mesh_terms: D000257:Adenoviridae Infections / Q000662:veterinary* / Q000821:virology; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D036022:Capsid Proteins / Q000737:chemistry / Q000235:genetics; D004279:DNA, Viral / Q000737:chemistry / Q000235:genetics; D004259:DNA-Directed DNA Polymerase / Q000737:chemistry / Q000235:genetics; D003967:Diarrhea / Q000662:veterinary* / Q000821:virology; D005243:Feces / Q000821:virology; D005260:Female; D008855:Microscopy, Electron, Scanning / Q000662:veterinary; D008969:Molecular Sequence Data; D008992:Monkey Diseases / Q000821:virology*; D010802:Phylogeny; D016133:Polymerase Chain Reaction / Q000662:veterinary; D012452:Saguinus; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D046809:Siadenovirus / Q000235:genetics / Q000302:isolation & purification* / Q000648:ultrastructure
chemical_list: D036022:Capsid Proteins; D004279:DNA, Viral; C018315:hexon capsid protein, Adenovirus; D004259:DNA-Directed DNA Polymerase