title: Examining variation in depressive symptoms over the life course: a latent class analysis.
abstract: BACKGROUND
  Older adults have the lowest prevalence and incidence of major depressive disorder, although it has been hypothesized that this finding is due in part to differences in expression of psychopathology in later life. The aim of this study was to examine variation in depressive symptomatology in the general population across the lifespan.
  
  
  METHODS
  Data came from three sites of the Epidemiologic Catchment Area (ECA) Project (n=10 529). Depressive symptoms during the past 6 months were assessed using the Diagnostic Interview Schedule (DIS). Latent class analysis (LCA) was used to identify homogeneous groups of depressive symptomatology based on 16 individual symptoms, and to examine variation in the prevalence and composition of depression classes across age groups.
  
  
  RESULTS
  The DIS symptoms fit a four-class model composed of non-depressed (83.2%), mild depression (11.6%), severe depression (1.9%), and despondent (3.2%) groups. Relative to the non-depressed class, older age was inversely associated with being in the mild or severe depression class. The profile of the latent classes was similar across age groups with the exception of the despondent class, which was not well differentiated among the youngest adults and was not inversely associated with age.
  
  
  CONCLUSIONS
  The symptom profiles of depression are similar across age with the exception of the despondent class, which is more differentiated from severe depression among older adults. The findings demonstrate the benefit of examining individual symptoms rather than broad symptom groups for understanding the natural history of depression over the lifespan.
authors.affiliation: Department of Epidemiology and Community Health, Virginia Commonwealth University, Richmond, VA 23298, USA. bmezuk@vcu.edu
authors.forename: B
authors.initials: B
authors.lastname: Mezuk
authors.forename: K S
authors.initials: KS
authors.lastname: Kendler
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000523:psychology*; D003866:Depressive Disorder / Q000453:epidemiology* / Q000523:psychology*; D005260:Female; D005852:Geriatric Psychiatry / Q000379:methods / Q000706:statistics & numerical data; D006801:Humans; D015994:Incidence; D007406:Interview, Psychological / Q000379:methods; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011569:Psychiatric Status Rating Scales; D012307:Risk Factors; D012720:Severity of Illness Index; D014481:United States; D055815:Young Adult