title: Lack of association between IL10 polymorphisms and sarcoidosis in Japanese patients.
abstract: OBJECTIVE
  To investigate whether interleukin 10 (IL10) gene polymorphisms are associated with the development of sarcoidosis in Japanese patients.
  
  
  METHODS
  Two hundred and eighty-eight Japanese sarcoidosis patients and 310 Japanese healthy controls were recruited. We genotyped 9 single-nucleotide polymorphisms in IL10 and assessed the allelic diversity between cases and controls.
  
  
  RESULTS
  No significant differences in the frequency of IL10 alleles, genotypes, and haplotypes in the sarcoidosis cases compared to the controls were detected.
  
  
  CONCLUSIONS
  Our results suggest that IL10 polymorphisms are not significantly related to the pathogenesis of sarcoidosis in the Japanese population.
authors.affiliation: Department of Ophthalmology and Visual Science, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan. ken136a@yahoo.co.jp
authors.forename: Kenichi
authors.initials: K
authors.lastname: Sakuyama
authors.forename: Akira
authors.initials: A
authors.lastname: Meguro
authors.forename: Masao
authors.initials: M
authors.lastname: Ota
authors.forename: Mami
authors.initials: M
authors.lastname: Ishihara
authors.forename: Riyo
authors.initials: R
authors.lastname: Uemoto
authors.forename: Haruyasu
authors.initials: H
authors.lastname: Ito
authors.forename: Eiichi
authors.initials: E
authors.lastname: Okada
authors.forename: Kenichi
authors.initials: K
authors.lastname: Namba
authors.forename: Nobuyoshi
authors.initials: N
authors.lastname: Kitaichi
authors.forename: Shin-ichiro
authors.initials: S
authors.lastname: Morimoto
authors.forename: Toshikatsu
authors.initials: T
authors.lastname: Kaburaki
authors.forename: Yasutaka
authors.initials: Y
authors.lastname: Ando
authors.forename: Shinobu
authors.initials: S
authors.lastname: Takenaka
authors.forename: Takenosuke
authors.initials: T
authors.lastname: Yuasa
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Ohno
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Inoko
authors.forename: Nobuhisa
authors.initials: N
authors.lastname: Mizuki
mesh_terms: D020121:5' Untranslated Regions; D000483:Alleles; D044466:Asian People; D016022:Case-Control Studies; D016172:DNA Fingerprinting; D005123:Eye / Q000378:metabolism* / Q000473:pathology; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D007438:Introns; D015810:Linkage Disequilibrium; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012507:Sarcoidosis / Q000235:genetics* / Q000473:pathology
chemical_list: D020121:5' Untranslated Regions; C508609:IL10 protein, human; D016753:Interleukin-10