title: Pyrrolidinyl peptide nucleic acid homologues: effect of ring size on hybridization properties.
abstract: The effect of ring size of four- to six-membered cyclic β-amino acid on the hybridization properties of pyrrolidinyl peptide nucleic acid with an alternating α/β peptide backbone is reported. The cyclobutane derivatives (acbcPNA) show the highest T(m) and excellent specificity with cDNA and RNA.
authors.affiliation: Organic Synthesis Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Phayathai Road, Patumwan, Bangkok 10330, Thailand.
authors.forename: Woraluk
authors.initials: W
authors.lastname: Mansawat
authors.forename: Chotima
authors.initials: C
authors.lastname: Vilaivan
authors.forename: Árpád
authors.initials: Á
authors.lastname: Balázs
authors.forename: David J
authors.initials: DJ
authors.lastname: Aitken
authors.forename: Tirayut
authors.initials: T
authors.lastname: Vilaivan
mesh_terms: D001483:Base Sequence; D003503:Cyclobutanes / Q000737:chemistry; D004247:DNA / Q000737:chemistry; D015394:Molecular Structure; D009693:Nucleic Acid Hybridization; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis / Q000737:chemistry*; D012313:RNA / Q000737:chemistry
chemical_list: D003503:Cyclobutanes; D020135:Peptide Nucleic Acids; D012313:RNA; D004247:DNA