title: Comparison of dual- and triple-freeze protocols for pulmonary cryoablation in a Tibet pig model.
abstract: The purpose of this study was to compare a dual-freeze protocol with a triple-freeze protocol for pulmonary cryoablation in a porcine lung model. Five dual- (10-5-10-5) and five triple-freeze (5-5-5-5-10-5) cryoablations were performed on an exposed operation field in normal porcine lung. Changes in the temperature of the cryoprobes and the diameter of the iceballs were measured during the ablation and pathologic changes in the cryozones (zones of tissue destruction) were reviewed 7 days after the procedure. The diameter of the iceball surface differed between the two protocols. Pathologically, the triple-freeze protocol was associated with a longer complete necrosis zone than the dual-freeze protocol, though the two protocols produced cryolesions and cryozones of similar length, and in both cases there were five areas of tissue destruction. With the same duration of freezing (20 min), the triple-freeze protocol may be better for pulmonary cryoablation than the dual-freeze protocol.
authors.affiliation: Guangzhou Fuda Cancer Hospital, Guangzhou, China.
authors.forename: Lizhi
authors.initials: L
authors.lastname: Niu
authors.forename: Jialiang
authors.initials: J
authors.lastname: Li
authors.forename: Jibing
authors.initials: J
authors.lastname: Chen
authors.forename: Liang
authors.initials: L
authors.lastname: Zhou
authors.forename: Binghui
authors.initials: B
authors.lastname: Wu
authors.forename: Jianying
authors.initials: J
authors.lastname: Zeng
authors.forename: Gang
authors.initials: G
authors.lastname: Fang
authors.forename: Chunjuan
authors.initials: C
authors.lastname: Deng
authors.forename: Fei
authors.initials: F
authors.lastname: Yao
authors.forename: Zhixian
authors.initials: Z
authors.lastname: Chen
authors.forename: Yin
authors.initials: Y
authors.lastname: Leng
authors.forename: Min
authors.initials: M
authors.lastname: Deng
authors.forename: Chunmei
authors.initials: C
authors.lastname: Deng
authors.forename: Bo
authors.initials: B
authors.lastname: Zhang
authors.forename: Maoxin
authors.initials: M
authors.lastname: Liao
authors.forename: Keqiang
authors.initials: K
authors.lastname: Xu
authors.forename: Jiansheng
authors.initials: J
authors.lastname: Zuo
authors.forename: Kecheng
authors.initials: K
authors.lastname: Xu
mesh_terms: D000818:Animals; D003452:Cryosurgery / Q000379:methods*; D005615:Freezing; D007053:Ice; D008168:Lung / Q000601:surgery*; D023421:Models, Animal; D009336:Necrosis / Q000473:pathology; D013552:Swine
chemical_list: D007053:Ice