title: Adverse reaction in patients with drug allergy history after simultaneous intravenous fundus fluorescein angiography and indocyanine green angiography.
abstract: OBJECTIVE
  To examine the safety of outpatient clinic simultaneous intravenous fundus fluorescein angiography (IVFA) and indocyanine green angiography (ICGA) in patients with any/all drug allergy history.
  
  
  METHODS
  In a single-center retrospective study conducted from February 2007 to March 2011, 390 consecutive outpatients with drug allergy history and 3426 patients without allergy history underwent simultaneous intravenous IVFA and ICGA. The detailed drug allergy history, the symptoms and time of the adverse reaction during simultaneous IVFA and ICGA were recorded in all the patients.
  
  
  RESULTS
  Of the 390 patients with drug allergy history who received IVFA and ICGA, 28 patients (7.2%) had an adverse reaction. In contrast, 145 of the 3426 patients (4.2%) without allergy history had an adverse reaction during simultaneous IVFA and ICGA. Statistical significance in the incidence (P=0.008) and severity (P=0.001) of the adverse reaction was observed between patients with drug allergy history and those without drug allergy history. In 390 patients with drug allergy history, no statistical significance was indicated in the incidence of the adverse reaction among different types of drug allergy (P>0.05).
  
  
  CONCLUSIONS
  Simultaneous IFVA and ICGA are generally safe procedures with an acceptable incidence of an adverse reaction. However, patients with drug allergy history may have a higher incidence and greater severity of an adverse reaction.
authors.affiliation: Eye Center, Second Affiliated Hospital, College of Medicine, Zhejiang University, No. 88 Jiefang Road, Hangzhou, China.
authors.forename: Zhaoan
authors.initials: Z
authors.lastname: Su
authors.forename: Panpan
authors.initials: P
authors.lastname: Ye
authors.forename: Yan
authors.initials: Y
authors.lastname: Teng
authors.forename: Lixia
authors.initials: L
authors.lastname: Zhang
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Shu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000792:Angiography / Q000009:adverse effects*; D002648:Child; D016001:Confidence Intervals; D004342:Drug Hypersensitivity / Q000150:complications* / Q000453:epidemiology; D005260:Female; D019793:Fluorescein / Q000009:adverse effects*; D005451:Fluorescein Angiography / Q000009:adverse effects*; D005654:Fundus Oculi; D006801:Humans; D007208:Indocyanine Green / Q000009:adverse effects*; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D018570:Risk Assessment; D055815:Young Adult
chemical_list: D007208:Indocyanine Green; D019793:Fluorescein