title: [Effect of different compatibility of Wuji Wan on bile excretion of representative ingredient].
abstract: OBJECTIVE
  To research the representative ingredient excretion in bile using the different compatibilities of Wuji Wan, in order to indicate the regularity of compatibility.
  
  
  METHODS
  L9 (3(4)) orthogonal design table was used, in addition 9 simples, altogether 18 compatibilities. After duodenal administration bile at different time spot was collected for LC-MS detection.
  
  
  RESULTS
  The excretion of Evodiae Fructus was negative correlated with that of berberine and palmatine in bile. The excretion of Paeoniae Radix Alba was positive correlated with that of berberine and palmatine in bile. The excretion of Coptidis Rhizoma, Paeoniae Radix Alba was negative correlated with that of evodiamine, rutaecarpine; meanwhile, the most superior proportion was also caculated which promote the representative ingredient excrete from bile.
  
  
  CONCLUSIONS
  Evodiae fructus suppresses representative ingredients of Coptidis Rhizoma excrete through bile. Paeoniae Radix Alba promote suppresses representative ingredients of Coptidis Rhizoma excrete through bile. Coptidis Rhizoma, paeoniae Radix Alba suppresses representative ingredients of Evodiae Fructus excrete through bile. Coptidis Rhizoma, Evodiae Fructus suppresses representative ingredients of Paeoniae Radix Alba excrete through bile.
authors.affiliation: China Academy of Chinese Medical Sciences, Institute of Chinese Materia Medica, Beijing 100700, China.
authors.forename: Yiwei
authors.initials: Y
authors.lastname: Wang
authors.forename: Yingfeng
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yujie
authors.initials: Y
authors.lastname: Li
authors.forename: Weipeng
authors.initials: W
authors.lastname: Yang
authors.forename: Yanli
authors.initials: Y
authors.lastname: Wang
authors.forename: Ying
authors.initials: Y
authors.lastname: Chen
authors.forename: Qing
authors.initials: Q
authors.lastname: Yang
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.forename: Yu
authors.initials: Y
authors.lastname: Dong
authors.forename: Xiaoxin
authors.initials: X
authors.lastname: Zhu
mesh_terms: D000818:Animals; D001599:Berberine / Q000032:analysis; D001600:Berberine Alkaloids / Q000032:analysis; D001646:Bile / Q000737:chemistry* / Q000378:metabolism; D002853:Chromatography, Liquid; D004339:Drug Compounding; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000493:pharmacokinetics*; D008297:Male; D013058:Mass Spectrometry; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
chemical_list: D001600:Berberine Alkaloids; D004365:Drugs, Chinese Herbal; D001599:Berberine; C005413:palmatine