title: The structure of glibenclamide in the solid state.
abstract: The structure of glibenclamide, 5-chloro-N-(2-{4-[(cyclohexylamino)carbonyl] aminosulfonyl}phenyl) ethyl)-2-methoxybenzamide, an important antidiabetic drug, has been studied both in solution and in the solid state by a combination of NMR spectroscopy and theoretical calculations. The possibility that glibenclamide suffers a tautomerization under melting to afford a desmotrope was rejected.
authors.affiliation: Departamento de Química Orgánica y Bio-Orgánica, Facultad de Ciencias, Universidad Nacional de Educación a Distancia (UNED), Madrid, Spain. dsanz@ccia.uned.es
authors.forename: Dionisia
authors.initials: D
authors.lastname: Sanz
authors.forename: Rosa M
authors.initials: RM
authors.lastname: Claramunt
authors.forename: Ibon
authors.initials: I
authors.lastname: Alkorta
authors.forename: Goar
authors.initials: G
authors.lastname: Sánchez-Sanz
authors.forename: José
authors.initials: J
authors.lastname: Elguero
mesh_terms: D018360:Crystallography, X-Ray; D005905:Glyburide / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy / Q000592:standards; D008958:Models, Molecular; D015394:Molecular Structure; D011789:Quantum Theory; D012015:Reference Standards
chemical_list: D005905:Glyburide