title: Fluoro-substituted ketones from nitriles using acidic and basic reaction conditions.
abstract: Fluoro-substituted aliphatic nitriles are shown to undergo the Houben-Hoesch reactions with arenes in CF(3)SO(3)H to give fluoro-substituted ketones in good yields. The fluorine substituents appear to enhance the reactivities of the nitriles (and the nitrilium ion intermediates) compared to similar aliphatic nitriles. Fluoro-substituted ketones are also shown to be accessible through the reactions of organometallic reagents and fluoro-substituted nitriles.
authors.affiliation: Department of Chemistry and Biochemistry, Northern Illinois University, DeKalb, IL 60115.
authors.forename: Erum
authors.initials: E
authors.lastname: Raja
authors.forename: Douglas A
authors.initials: DA
authors.lastname: Klumpp