title: Philadelphia-negative chromosomal evolution during  treatment for chronic myeloid leukemia.
abstract: Chromosome evolution is one of the major mechanisms of  disease progression and resistance in chronic myeloid leukemia (CML) patients.  However, the clinical significance of chromosomal evolution in the Philadelphia  (Ph)-negative clone during therapy is not fully understood. We evaluated 94 CML  patients in the chronic phase of CML during treatment of the disease. Six of  them had Ph-negative chromosome abnormalities during treatment. Four patients  with a single abnormality and a good molecular response showed no obvious  complications from the chromosomal changes, while two other patients who had  complex abnormalities and previous treatment had poor outcomes. Our results  highlight the need for close monitoring of this kind of patient, not only on a  molecular level but also at the cytogenetic level.
authors.affiliation: Faculty of Medicine, Kaohsiung Medical University, Taiwan.
authors.forename: H-H
authors.initials: HH
authors.lastname: Hsiao
authors.forename: Y-C
authors.initials: YC
authors.lastname: Liu
authors.forename: C-P
authors.initials: CP
authors.lastname: Lee
authors.forename: C-S
authors.initials: CS
authors.lastname: Chang
authors.forename: S-F
authors.initials: SF
authors.lastname: Lin
mesh_terms: D000328:Adult; D000368:Aged; D001853:Bone Marrow; D001854:Bone Marrow Cells / Q000166:cytology*; D002869:Chromosome Aberrations; D018450:Disease Progression; D005260:Female; D006801:Humans; D054438:Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D033581:Stem Cell Transplantation; D055815:Young Adult