title: Unresolved, atraumatic breast hematoma: post-irradiation or secondary breast angiosarcoma.
abstract: Post-irradiation or secondary angiosarcoma of the breast was first described in the 1980s in patients treated with breast conserving therapy for cancer. The primary management of radiation-induced breast angiosarcoma has focused on surgical resection with an emphasis on achieving negative tumor margins. While surgery remains a key component of treatment, novel therapeutic approaches have surfaced. Despite such advances in treatment, prognosis remains poor.
authors.affiliation: Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
authors.forename: Glenn
authors.initials: G
authors.lastname: Hanna
authors.forename: Samuel J
authors.initials: SJ
authors.lastname: Lin
authors.forename: Michael D
authors.initials: MD
authors.lastname: Wertheimer
authors.forename: Ranjna
authors.initials: R
authors.lastname: Sharma
mesh_terms: D001941:Breast Diseases / Q000175:diagnosis / Q000209:etiology*; D001943:Breast Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000532:radiotherapy*; D018270:Carcinoma, Ductal, Breast / Q000473:pathology / Q000532:radiotherapy; D003937:Diagnosis, Differential; D005260:Female; D006394:Hemangiosarcoma / Q000175:diagnosis / Q000209:etiology*; D006406:Hematoma / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000175:diagnosis; D016609:Neoplasms, Second Primary / Q000175:diagnosis