title: Monoterpene glucosides from Ziziphora clinopodioides (Labiatae).
abstract: Three new monoterpene glucosides, ziziphoroside A (1), B (2), and C (3), together with fifteen known compounds were isolated from the whole herb of Z. clinopodioides. The structures of new compounds were determined primarily from 1D-, 2D-NMR and circular dichroism (CD) spectroscopic analyses. The isolated compounds were evaluated for their inhibitory activity against nitric oxide (NO) production by lipopolysaccharide (LPS) and interferon (IFN)-γ activated macrophages, RAW 264.7. Shizonepetoside A (8) and flavones (11, 12, 13) showed potent inhibitory activity against NO production.
authors.affiliation: School of Pharmacy, Department of Chemistry, College of Humanities and Sciences, Nihon University, Chiba, Japan.
authors.forename: Megumi
authors.initials: M
authors.lastname: Furukawa
authors.forename: Naoki
authors.initials: N
authors.lastname: Oikawa
authors.forename: Toru
authors.initials: T
authors.lastname: Imohata
authors.forename: Mitsuko
authors.initials: M
authors.lastname: Makino
authors.forename: Shoujiro
authors.initials: S
authors.lastname: Ogawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Iida
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Fujimoto
authors.forename: Susumu
authors.initials: S
authors.lastname: Kitanaka
mesh_terms: D000818:Animals; D002460:Cell Line; D002942:Circular Dichroism / Q000379:methods; D047309:Flavones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005960:Glucosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D007371:Interferon-gamma / Q000494:pharmacology; D019686:Lamiaceae / Q000737:chemistry*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D008279:Magnetic Resonance Imaging / Q000379:methods; D051379:Mice; D039821:Monoterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D009569:Nitric Oxide / Q000037:antagonists & inhibitors; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry
chemical_list: D047309:Flavones; D005960:Glucosides; D008070:Lipopolysaccharides; D039821:Monoterpenes; D010936:Plant Extracts; D009569:Nitric Oxide; D007371:Interferon-gamma