title: Sleep disorders in morbid obesity.
abstract: The increasing prevalence of obesity has lead to an increase in the prevalence of sleep disordered breathing in the general population. The disproportionate structural characteristics of the pharyngeal airway and the diminished neural regulation of the pharyngeal dilating muscles during sleep predispose the obese patients to pharyngeal airway collapsibility. A subgroup of obese apneic patients is unable to compensate for the added load of obesity on the respiratory system, with resultant daytime hypercapnia. Weight loss using dietary modification and life style changes is the safest approach to reducing the severity of sleep apnea, but its efficacy is limited on the long run. Although it has inherent risks, bariatric surgery provides the most immediate result in alleviating sleep apnea. Obesity has been linked also to narcolepsy. The loss of neuropeptides co-localized in hypocretin neurons is suggested as the potential mechanism. Poor sleep quality, which leads to overall sleep loss and excessive daytime sleepiness has also become a frequent complaint in this population. Identifying abnormal nocturnal eating is critically important for patient care. Both sleep related eating disorder and night eating syndrome are treatable and represent potentially reversible forms of obesity.
authors.affiliation: The Veterans Affairs Western New York Healthcare System, Buffalo, NY, United States.
authors.forename: Morohunfolu E
authors.initials: ME
authors.lastname: Akinnusi
authors.forename: Ranime
authors.initials: R
authors.lastname: Saliba
authors.forename: Jahan
authors.initials: J
authors.lastname: Porhomayon
authors.forename: Ali A
authors.initials: AA
authors.lastname: El-Solh
mesh_terms: D006801:Humans; D009767:Obesity, Morbid / Q000453:epidemiology* / Q000601:surgery / Q000628:therapy*; D015995:Prevalence; D012307:Risk Factors; D012893:Sleep Wake Disorders / Q000453:epidemiology* / Q000628:therapy*