title: Resting metabolic connectivity in prodromal Alzheimer's disease. A European Alzheimer Disease Consortium (EADC) project.
abstract: We explored resting-state metabolic connectivity in prodromal Alzheimer's disease (pAD) patients and in healthy controls (CTR), through a voxel-wise interregional correlation analysis of 18F-fluorodeoxyglucose (FDG)-positron emission tomography (PET) by means of statistical parametric mapping. Baseline 18F-fluorodeoxyglucose-positron emission tomography of 36 patients with amnestic mild cognitive impairment who converted to Alzheimer's disease (AD) dementia after an average time of 2 years (pAD) and of 105 CTR were processed. The area of hypometabolism in pAD showed less metabolic connectivity in patients than in CTR (autocorrelation and correlation with large temporal and frontal areas, respectively). pAD patients showed limited correlation even in selected nonhypometabolic areas, including the hippocampi and the dorsolateral prefrontal cortex (DLFC). On the contrary, in CTR group correlation was highlighted between hippocampi and precuneus/posterior cingulate and frontal cortex, and between dorsolateral prefrontal cortex and caudate nuclei and parietal cortex. The reduced metabolic connections both in hypometabolic and nonhypometabolic areas in pAD patients suggest that metabolic disconnection (reflecting early diaschisis) may antedate remote hypometabolism (early sign of synaptic degeneration).
authors.affiliation: Nuclear Medicine Unit, Department of Internal Medicine, San Martino University Hospital, Genoa, Italy. silviadaniela.morbelli@hsanmartino.it
authors.forename: Silvia
authors.initials: S
authors.lastname: Morbelli
authors.forename: Alex
authors.initials: A
authors.lastname: Drzezga
authors.forename: Robert
authors.initials: R
authors.lastname: Perneczky
authors.forename: Giovanni B
authors.initials: GB
authors.lastname: Frisoni
authors.forename: Anna
authors.initials: A
authors.lastname: Caroli
authors.forename: Bart N M
authors.initials: BN
authors.lastname: van Berckel
authors.forename: Rik
authors.initials: R
authors.lastname: Ossenkoppele
authors.forename: Eric
authors.initials: E
authors.lastname: Guedj
authors.forename: Mira
authors.initials: M
authors.lastname: Didic
authors.forename: Andrea
authors.initials: A
authors.lastname: Brugnolo
authors.forename: Gianmario
authors.initials: G
authors.lastname: Sambuceti
authors.forename: Marco
authors.initials: M
authors.lastname: Pagani
authors.forename: Eric
authors.initials: E
authors.lastname: Salmon
authors.forename: Flavio
authors.initials: F
authors.lastname: Nobili
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000378:metabolism*; D001931:Brain Mapping; D003072:Cognition Disorders / Q000175:diagnosis / Q000378:metabolism*; D005260:Female; D019788:Fluorodeoxyglucose F18; D005500:Follow-Up Studies; D006624:Hippocampus / Q000378:metabolism; D006801:Humans; D007090:Image Interpretation, Computer-Assisted / Q000379:methods; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods; D012146:Rest
chemical_list: D019788:Fluorodeoxyglucose F18