title: Vitamin D modulates airway smooth muscle function in COPD.
abstract: COPD is a disease manifested as persistent airflow obstruction with an enhanced inflammatory response in the airways and lungs to noxious particles and gases which evokes symptoms of dyspnea on exertion, cough and mucus production. Airway smooth muscle plays a central role in the COPD diathesis and is implicated in many aspects of COPD pathogenesis. Vitamin D deficiency has been associated with COPD severity and studies suggest a role for Vitamin D as a treatment for COPD. In this review, we describe the effects of 1,25-dihydroxyvitamin D on airway smooth muscle function, including agonist-induced shortening, secretion of inflammatory mediators, and myocyte hypertrophy and hyperplasia.
authors.affiliation: Department of Medicine, Airways Biology Initiative, Division of Pulmonary, Allergy and Critical Care Medicine, Hospital of University of Pennsylvania, Philadelphia, PA, United States.
authors.forename: Audreesh
authors.initials: A
authors.lastname: Banerjee
authors.forename: Reynold
authors.initials: R
authors.lastname: Panettieri
mesh_terms: D056151:Airway Remodeling / Q000187:drug effects; D016084:Bronchoconstriction / Q000187:drug effects; D002117:Calcitriol / Q000378:metabolism / Q000627:therapeutic use*; D002453:Cell Cycle / Q000187:drug effects; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D009130:Muscle, Smooth / Q000187:drug effects / Q000276:immunology / Q000503:physiopathology*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology*; D012132:Respiratory Muscles / Q000187:drug effects / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology*; D012720:Severity of Illness Index; D015398:Signal Transduction / Q000187:drug effects; D014807:Vitamin D / Q000378:metabolism / Q000627:therapeutic use; D014808:Vitamin D Deficiency / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D019061:src-Family Kinases / Q000737:chemistry / Q000378:metabolism
chemical_list: D018836:Inflammation Mediators; D014807:Vitamin D; D019869:Phosphatidylinositol 3-Kinases; D019061:src-Family Kinases; D002117:Calcitriol