title: Is the fear of dioxin cancer more harmful than dioxin?
abstract: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a proven animal carcinogen. Occupational cohorts with the highest exposures imply that there is a small risk of all cancers combined, but it is difficult to pinpoint the confounding effect of the main chemicals. Studies after major accidents do not unequivocally confirm this risk. The risks to populations at the current dioxin levels seem trivial if present at all. There is increasing evidence that the aryl hydrocarbon receptor (AhR), i.e. the so called "dioxin receptor", is a physiological transcription factor exerting important functions in the body. Consequently a certain level of AhR activation may be beneficial rather than harmful. This challenges the wisdom of excessive regulation of dioxin levels in certain foods and nutrients. This could pose indirect nutritional risks, in fact being more harmful than even the worst case predictions of the putative cancer risks attributable to dioxins.
authors.affiliation: Department of Environmental Health, National Institute for Health and Welfare (THL), P.O. Box 95, FI-70701 Kuopio, Finland. jouko.tuomisto@thl.fi
authors.forename: Jouko
authors.initials: J
authors.lastname: Tuomisto
authors.forename: Jouni T
authors.initials: JT
authors.lastname: Tuomisto
mesh_terms: D000818:Animals; D004147:Dioxins / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D009369:Neoplasms / Q000139:chemically induced*; D000072317:Polychlorinated Dibenzodioxins / Q000633:toxicity; D018336:Receptors, Aryl Hydrocarbon / Q000502:physiology; D012306:Risk; D012509:Sarcoma / Q000139:chemically induced
chemical_list: D004147:Dioxins; D000072317:Polychlorinated Dibenzodioxins; D018336:Receptors, Aryl Hydrocarbon