title: Vascular endothelial growth factor gene polymorphisms and endometriosis risk: a meta-analysis.
abstract: OBJECTIVE
  The vascular endothelial growth factor (VEGF) gene polymorphism has been reported to be associated with endometriosis risk. The purpose of the present study was to perform a comprehensive meta-analysis to explore whether VEGF gene polymorphisms confer risk to endometriosis.
  
  
  METHODS
  By searching PubMed and EMBASE databases, a total of 11 studies were identified. Crude odds ratio (OR) and their corresponding 95% confidence intervals (CI) for VEGF gene polymorphisms and endometriosis risk were calculated.
  
  
  RESULTS
  An association of VEGF gene +936TC polymorphism with endometriosis was found (Fixed-effect model: TT + TC vs. CC: OR 1.184, 95% CI 1.027-1.366, P = 0.020; TC vs. CC: OR 1.187, 95% CI 1.024-1.375, P = 0.023. Random-effect model: TT + TC vs. CC: OR 1.203, 95% CI 1.003-1.443, P = 0.046; TC vs. CC: OR 1.188, 95% CI 1.021-1.382, P = 0.026). No association between VEGF genes -460CT, +405CG, -2578AC, -1154GA polymorphisms and endometriosis was observed.
  
  
  CONCLUSIONS
  Our results indicate that VEGF +936TC gene polymorphism is a risk factor for endometriosis, and not -460CT, +405CG, -2578AC, -1154GA.
authors.affiliation: Guangxi Medical University, Nanning, Guangxi, People's Republic of China.
authors.forename: Shoujun
authors.initials: S
authors.lastname: Liang
authors.forename: Yin
authors.initials: Y
authors.lastname: Huang
authors.forename: Yujuan
authors.initials: Y
authors.lastname: Fan
mesh_terms: D004715:Endometriosis / Q000235:genetics*; D005260:Female; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics*
chemical_list: D042461:Vascular Endothelial Growth Factor A