title: Predictors of the development of surgical complications among hematopoietic stem cell transplantation recipients.
abstract: BACKGROUND
  This study was designed to determine possible risk factors for the development of surgical complications after hematopoietic stem cell transplantation (HSCT). HSCT carries the possibility for the development of surgical morbidities and mortalities; certain populations of patients are at higher risk for developing complications. Defining those risk factors will help surgeons to anticipate and manage these complications.
  
  
  METHODS
  The records of 165 patients at King Hussein Cancer Center (KHCC) were reviewed from January 2007 to December 2008. Patients' characteristics, including age, source and type of transplant, behavior of disease, total body irradiation (TBI), immunity status, and intensity of conditioning were studied.
  
  
  RESULTS
  According to our data, abdominal complications were more common among patients who received TBI versus patients who did not, and in patients who received peripheral blood versus bone marrow and cord blood as the source of stem cells. Ear, nose, and throat (ENT) complications were found more in patients who underwent nonmyeloablation conditioning. Catheter-related complications were found more significantly in immune-compromised patients during the post-engraftment period. We also found that ENT complications were more frequent in patients with cord blood as the source of stem cells, although the results are inconclusive due to the small sample size.
  
  
  CONCLUSIONS
  Pretransplantation factors can be used as predictors for the development of surgical complications in HSCT recipients. Abdominal complications were significantly more common in patients who received total body irradiation as part of their conditioning regimen and when the peripheral blood was a source for stem cell transplantation.
authors.affiliation: Department of Surgery, King Hussein Cancer Center, Queen Rania Street, P.O. Box 1269, Al-Jubeiha, Amman, 11941, Jordan.
authors.forename: Iyad
authors.initials: I
authors.lastname: Anabtawi
authors.affiliation: Department of Bone Marrow and Stem Cell Transplantation Program, King Hussein Cancer Center, Amman, Jordan.
authors.forename: Fawzi
authors.initials: F
authors.lastname: Abdelrahman
authors.affiliation: Department of Surgery, King Hussein Cancer Center, Queen Rania Street, P.O. Box 1269, Al-Jubeiha, Amman, 11941, Jordan.
authors.forename: Ahamd
authors.initials: A
authors.lastname: Alomari
authors.affiliation: Department of Surgery, King Hussein Cancer Center, Queen Rania Street, P.O. Box 1269, Al-Jubeiha, Amman, 11941, Jordan.
authors.forename: Murad
authors.initials: M
authors.lastname: Ba'ba'
authors.affiliation: Department of Surgery, King Hussein Cancer Center, Queen Rania Street, P.O. Box 1269, Al-Jubeiha, Amman, 11941, Jordan. malmasri@khcc.jo.
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Al Masri
mesh_terms: D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D036101:Cord Blood Stem Cell Transplantation; D005260:Female; D005500:Follow-Up Studies; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007223:Infant; D008297:Male; D036102:Peripheral Blood Stem Cell Transplantation; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology*; D012189:Retrospective Studies; D012307:Risk Factors; D019172:Transplantation Conditioning / Q000009:adverse effects / Q000379:methods; D014916:Whole-Body Irradiation; D055815:Young Adult