title: Principles of nuclear medicine imaging: planar, SPECT, PET, multi-modality, and autoradiography systems.
abstract: The underlying principles of nuclear medicine imaging involve the use of unsealed sources of radioactivity in the form of radiopharmaceuticals. The ionizing radiations that accompany the decay of the administered radioactivity can be quantitatively detected, measured, and imaged in vivo with instruments such as gamma cameras. This paper reviews the design and operating principles, as well as the capabilities and limitations, of instruments used clinically and preclinically for in vivo radionuclide imaging. These include gamma cameras, single-photon emission computed tomography (SPECT) scanners, and positron emission tomography (PET) scanners. The technical basis of autoradiography is reviewed as well.
authors.affiliation: Department of Medical Physics, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA. ZanzoniP@MSKCC.ORG
authors.forename: Pat
authors.initials: P
authors.lastname: Zanzonico
mesh_terms: D000818:Animals; D001345:Autoradiography / Q000295:instrumentation / Q000379:methods; D003952:Diagnostic Imaging / Q000295:instrumentation / Q000379:methods*; D004867:Equipment Design; D015902:Gamma Cameras; D006801:Humans; D051379:Mice; D057054:Molecular Imaging / Q000295:instrumentation / Q000379:methods; D009683:Nuclear Medicine / Q000295:instrumentation / Q000379:methods*; D049268:Positron-Emission Tomography / Q000295:instrumentation / Q000379:methods; D011839:Radiation, Ionizing; D011853:Radiobiology; D011874:Radiometry / Q000295:instrumentation; D011877:Radionuclide Imaging / Q000295:instrumentation / Q000379:methods; D019275:Radiopharmaceuticals; D051381:Rats; D012680:Sensitivity and Specificity; D014054:Tomography; D015899:Tomography, Emission-Computed, Single-Photon / Q000295:instrumentation / Q000379:methods; D051598:Whole Body Imaging
chemical_list: D019275:Radiopharmaceuticals