title: Antimicrobial activity of polyphenol-rich fractions from Sida alba L. (Malvaceae) against co-trimoxazol-resistant bacteria strains.
abstract: BACKGROUND
  The increased resistance of microorganisms to the currently used antimicrobials has lead to the evaluation of other agents that might have antimicrobial activity. Medicinal plants are sources of phytochemicals which are able to initiate different biological activities including antimicrobials
  
  
  METHODS
  In vitro antibacterial (MIC, MBC and time-kill studies) of polyphenol-rich fractions from Sida alba L. (Malvaceae) was assessed using ten bacteria strains (Gram-negative and Gram-positive).
  
  
  RESULTS
  All test bacteria were susceptible to the polyphenol-rich fractions. Time-kill results showed that after 5 h exposition there was no viable microorganism in the initial inoculum and the effect of polyphenol-rich fractions was faster on Enterococcus faecalis (Gram-positive bacterium) comparatively to the other bacteria strains.
  
  
  CONCLUSIONS
  The data analysis indicates that the tested of polyphenol-rich fractions has significant effects when compared with the standard antibiotic. These results therefore justify the traditional use of sida alba L., alone or in combination with other herbs to treat bacterial infections.
authors.affiliation: Laboratoire de Biochimie et Chimie Appliquées-LABIOCA, UFR/SVT, Université de Ouagadougou, 09 BP 848 Ouagadougou 09, Burkina Faso. mehekiessoum@yahoo.fr
authors.forename: Kiessoun
authors.initials: K
authors.lastname: Konaté
authors.forename: Adama
authors.initials: A
authors.lastname: Hilou
authors.forename: Jacques François
authors.initials: JF
authors.lastname: Mavoungou
authors.forename: Alexis Nicaise
authors.initials: AN
authors.lastname: Lepengué
authors.forename: Alain
authors.initials: A
authors.lastname: Souza
authors.forename: Nicolas
authors.initials: N
authors.lastname: Barro
authors.forename: Jacques Y
authors.initials: JY
authors.lastname: Datté
authors.forename: Bertrand
authors.initials: B
authors.lastname: M'batchi
authors.forename: Odile Germaine
authors.initials: OG
authors.lastname: Nacoulma
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D013293:Enterococcus faecalis / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D019660:Malvaceae / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D059808:Polyphenols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D010936:Plant Extracts; D059808:Polyphenols; D015662:Trimethoprim, Sulfamethoxazole Drug Combination