title: Transdermal microemulsion drug delivery system for impairing male reproductive toxicity and enhancing efficacy of Tripterygium Wilfordii Hook f.
abstract: The present study is trying to produce a transdermal microemulsion drug delivery system (TMDDS) for Tripterygium Wilfordii Hook f. (TWHF) and attempting to solve male reproductive toxicity problem of TWHF. The formulation was optimized by the central composite design with response surface methodology and was decided as 12% oleic acid, 19.7% Labrasol S, 19.7% ethanol and 19.7% Pharmasolve, and 29% water. TMDDS for TWHF had stronger transdermal ability than free TWHF, and TWHF microemulsion significantly inhibited the adjuvant-induced arthritis and at the same time, had preferable anti-inflammatory effect with the long-time administration. Various pharmacodynamics parameters proved that TWHF microemulsion can reduce the male reproductive toxicity and hepatotoxicity of rats. All these suggested that TMDDS could be a suitable delivery system for TWHF.
authors.affiliation: Key Laboratory of Smart Drug Delivery, Ministry of Education & PLA, Department of Pharmaceutics, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Wang
authors.forename: Mei
authors.initials: M
authors.lastname: Xue
authors.forename: Jijin
authors.initials: J
authors.lastname: Gu
authors.forename: Xiaoling
authors.initials: X
authors.lastname: Fang
authors.forename: Xianyi
authors.initials: X
authors.lastname: Sha
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000627:therapeutic use / Q000633:toxicity; D001168:Arthritis / Q000139:chemically induced / Q000517:prevention & control*; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D016503:Drug Delivery Systems; D004655:Emulsions; D008297:Male; D052801:Male Urogenital Diseases / Q000139:chemically induced / Q000517:prevention & control*; D010936:Plant Extracts / Q000008:administration & dosage* / Q000627:therapeutic use / Q000633:toxicity; D051381:Rats; D029757:Tripterygium / Q000633:toxicity*; D014867:Water / Q000737:chemistry
chemical_list: D000893:Anti-Inflammatory Agents; D004655:Emulsions; D010936:Plant Extracts; D014867:Water