title: Dioxindole in asymmetric catalytic synthesis: direct access to 3-substituted 3-hydroxy-2-oxindoles via 1,4-additions to nitroalkenes.
abstract: The asymmetric Michael addition of dioxindoles to β-substituted nitroalkenes is reported. The bifunctional primary amine-thiourea A, by means of a non-covalent-based mode of catalysis, secures direct access to 3-substituted 3-hydroxyoxindole derivatives with high stereocontrol.
authors.affiliation: Institute of Chemical Research of Catalonia, Av. Països Catalans 16, 43007 Tarragona, Spain.
authors.forename: Michele
authors.initials: M
authors.lastname: Retini
authors.forename: Giulia
authors.initials: G
authors.lastname: Bergonzini
authors.forename: Paolo
authors.initials: P
authors.lastname: Melchiorre
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000588:Amines / Q000737:chemistry; D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis*; D015394:Molecular Structure; D009574:Nitro Compounds / Q000737:chemistry*; D013237:Stereoisomerism; D013890:Thiourea / Q000031:analogs & derivatives / Q000737:chemistry
chemical_list: D000475:Alkenes; D000588:Amines; D007211:Indoles; D009574:Nitro Compounds; D013890:Thiourea