title: Three novel cyclic hexapeptides from Streptomyces alboflavus 313 and their antibacterial activity.
abstract: Three novel cyclic hexapeptides, designated NW-G05 (1), NW-G06 (2) and NW-G07 (3), were isolated from the fermentation broth of Streptomyces alboflavus 313. Their structures were elucidated on the basis of extensive spectroscopic analysis, MS experiments, and chemical analysis. Their antibacterial activities against several strains of bacteria were evaluated by micro-broth dilution method. Among these compounds, NW-G06 (2) and NW-G07 (3) displayed highly antibacterial activity against gram-positive bacteria, but not gram negative ones. However, NW-G05 (1) was not active against all tested microorganisms.
authors.affiliation: State Key Laboratory of Crop Stress Biology in Arid Areas, Institute of Pesticide Science, Northwest A & F University, Xinong 61#, Yangling, Shaanxi 712100, PR China. jizhiqin@nwsuaf.edu.cn
authors.forename: Zhiqin
authors.initials: Z
authors.lastname: Ji
authors.forename: Shaopeng
authors.initials: S
authors.lastname: Wei
authors.forename: Lixia
authors.initials: L
authors.lastname: Fan
authors.forename: Wenjun
authors.initials: W
authors.lastname: Wu
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D005285:Fermentation; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000302:isolation & purification* / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D013055:Spectrophotometry, Infrared; D013302:Streptomyces / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; C573631:NW-G05; C573632:NW-G06; C573633:NW-G07; D010456:Peptides, Cyclic