title: Synthesis of functional acetylene derivatives from calcium carbide.
abstract: AHA Erlebnis: CaC(2), used to produce acetylene until several decades ago, is re-emerging as a cheap, sustainable resource synthesized from coal and lignocellulosic biomass. We report efficient catalytic protocols for the synthesis of functional acetylene derivatives from CaC(2) through aldehyde, alkyne, and amine (AAA) as well as alkyne, haloalkane, and amine (AHA) couplings, and in addition demonstrate its use in click and Sonogashira chemistry, showing that calcium carbide is a sustainable and cost-efficient carbon source.
authors.affiliation: Institute of Bioengineering and Nanotechnology, 31 Biopolis Way, The Nanos, Singapore, Singapore.
authors.forename: Zhewang
authors.initials: Z
authors.lastname: Lin
authors.forename: Dingyi
authors.initials: D
authors.lastname: Yu
authors.forename: Yin Ngai
authors.initials: YN
authors.lastname: Sum
authors.forename: Yugen
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000114:Acetylene / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D003500:Cyclization
chemical_list: C006873:calcium carbide; D000114:Acetylene