title: Partial small bowel resection with sleeve gastrectomy increases adiponectin levels and improves glucose homeostasis in obese rodents with type 2 diabetes.
abstract: BACKGROUND
  The aim of this study was to examine the effect of small bowel resection with and without sleeve gastrectomy on glucose homeostasis in an obese rodent model of type 2 diabetes.
  
  
  METHODS
  Zucker diabetic fatty rats were randomized into three surgical groups: Sham, small bowel resection, and small bowel resection with sleeve gastrectomy (BRSG). Weight and fasting glucose levels were measured at randomization and monitored after surgery. Oral glucose tolerance testing was performed at baseline and 45 days after surgery to assess glucose homeostasis and peptide changes.
  
  
  RESULTS
  At baseline, all animals exhibited impaired glucose tolerance and showed no difference in weight or fasting (area under the curve) AUC(glucose). At sacrifice, Sham animals weighed more than BRSG animals (p = 0.047). At day 45, the Sham group experienced a significant increase in AUC(glucose) compared to baseline (p = 0.02), whereas there was no difference in AUC(glucose) in either surgical group at any time point: BR (p = 0.58) and BRSG (p = 0.56). Single-factor ANOVA showed a significant difference in AUC(glucose) of p = 0.004 between groups postoperatively: Sham (50,745 ± 11,170) versus BR (23,865 ± 432.6) (p = 0.01); Sham versus BRSG (28,710 ± 3188.8) (p = 0.02). There was no difference in plasma insulin, GLP-1, or adiponectin levels before surgery, although 45 days following surgery adiponectin levels where higher in the BRSG group (p = 0.004).
  
  
  CONCLUSIONS
  Partial small bowel resection improved glucose tolerance independent of weight. The combination of small bowel resection and sleeve gastrectomy leads to an increase in adiponectin levels, which may contribute to improved glucose homeostasis.
authors.affiliation: College of Physicians and Surgeons, Columbia University, New York, New York, USA.
authors.forename: Gift
authors.initials: G
authors.lastname: Kopsombut
authors.forename: Rivka
authors.initials: R
authors.lastname: Shoulson
authors.forename: Luca
authors.initials: L
authors.lastname: Milone
authors.forename: Judith
authors.initials: J
authors.lastname: Korner
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Lifante
authors.forename: Manu
authors.initials: M
authors.lastname: Sebastian
authors.forename: William B
authors.initials: WB
authors.lastname: Inabnet
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000818:Animals; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications / Q000601:surgery*; D005743:Gastrectomy / Q000379:methods*; D052216:Glucagon-Like Peptide 1 / Q000097:blood; D005951:Glucose Tolerance Test; D006706:Homeostasis; D007328:Insulin / Q000097:blood; D007421:Intestine, Small / Q000601:surgery*; D008297:Male; D009765:Obesity / Q000097:blood / Q000150:complications / Q000601:surgery*; D011897:Random Allocation; D051381:Rats; D011924:Rats, Zucker; D016896:Treatment Outcome; D015431:Weight Loss
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D001786:Blood Glucose; D007328:Insulin; D052216:Glucagon-Like Peptide 1