title: The use of sodium hyaluronate-carboxymethylcellulose to prevent postoperative mastication pain from harvesting of temporalis fascia.
abstract: OBJECTIVE
  To evaluate the anti-adhesive and anti-inflammatory effects of sodium hyaluronate-carboxymethylcellulose (HA-CMC) in reducing postoperative pain after temporalis fascia harvest during tympanomastoid surgery.
  
  
  METHODS
  Between January and December 2009, 27 patients underwent tympanoplasty and open cavity mastoidectomy involving the harvesting of temporalis fasciae (more than 3×4cm). At the end of surgery, patients were injected with 1.5g HA-CMC or normal saline around the fascia harvest area. Beginning immediately postoperatively and for 2 months after surgery, patients scored their pain in the temporal area on a visual analogue scale (VAS).
  
  
  RESULTS
  There were no significant postoperative complications, such as bleeding or hematoma, in either control group. VAS scores of both groups decreased over time and were negligible after 2 months. VAS scores of the HA-CMC and control groups differed significantly (p<0.001 by repeated measures ANOVA for all VAS scores).
  
  
  CONCLUSIONS
  HA-CMC can decrease immediate postoperative pain arising from tissue adhesion and inflammation, thus reducing postoperative mastication pain.
authors.affiliation: Department of Otolaryngology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea. meniere@amc.seoul.kr
authors.forename: Joong Ho
authors.initials: JH
authors.lastname: Ahn
authors.forename: Myung Joo
authors.initials: MJ
authors.lastname: Shim
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D002266:Carboxymethylcellulose Sodium / Q000627:therapeutic use*; D004337:Drug Carriers; D005205:Fascia / Q000637:transplantation; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000627:therapeutic use*; D008297:Male; D008409:Mastication; D008416:Mastoid / Q000601:surgery; D008875:Middle Aged; D010147:Pain Measurement; D010149:Postoperative Pain / Q000209:etiology / Q000517:prevention & control*; D011446:Prospective Studies; D016037:Single-Blind Method; D000267:Tissue Adhesions / Q000517:prevention & control; D060053:Transplant Donor Site; D014433:Tympanoplasty; D055675:Viscosupplements / Q000627:therapeutic use*
chemical_list: D004337:Drug Carriers; D055675:Viscosupplements; D006820:Hyaluronic Acid; D002266:Carboxymethylcellulose Sodium