title: Hydrogen sulfide producing enzymes in pregnancy and preeclampsia.
abstract: Preeclampsia, a human pregnancy specific disorder is characterized by an anti-angiogenic state. As hydrogen sulfide (H(2)S) has pro-angiogenic and anti-oxidative characteristics, we hypothesized that H(2)S levels could play a role in the pathogenesis of preeclampsia and studied the placental expression of the H(2)S-producing enzymes cystathionine-γ-lyase (CSE) and cystathionine-β-synthase (CBS). CBS and CSE protein are expressed in the fetal-placental endothelium and CBS only in Hofbauer cells. CBS mRNA expression is decreased (p = 0.002) in early-onset preeclampsia, while CSE mRNA is unchanged. Thus, down regulation of CBS during early-onset preeclampsia may result in less H(2)S-production and may aid in the anti-angiogenic state.
authors.affiliation: Department of Pathology and Medical Biology, Division of Pathology, University Medical Center Groningen, Hanzeplein 1, PO Box 30001, 9713 GZ Groningen, The Netherlands. k.m.holwerda@umcg.nl
authors.forename: K M
authors.initials: KM
authors.lastname: Holwerda
authors.forename: E M
authors.initials: EM
authors.lastname: Bos
authors.forename: A
authors.initials: A
authors.lastname: Rajakumar
authors.forename: C
authors.initials: C
authors.lastname: Ris-Stalpers
authors.forename: M G
authors.initials: MG
authors.lastname: van Pampus
authors.forename: A
authors.initials: A
authors.lastname: Timmer
authors.forename: J J H M
authors.initials: JJ
authors.lastname: Erwich
authors.forename: M M
authors.initials: MM
authors.lastname: Faas
authors.forename: H
authors.initials: H
authors.lastname: van Goor
authors.forename: A T
authors.initials: AT
authors.lastname: Lely
mesh_terms: D000328:Adult; D003541:Cystathionine beta-Synthase / Q000096:biosynthesis*; D003542:Cystathionine gamma-Lyase / Q000096:biosynthesis*; D015536:Down-Regulation; D005260:Female; D006801:Humans; D006862:Hydrogen Sulfide / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000201:enzymology* / Q000209:etiology; D011247:Pregnancy / Q000502:physiology*; D012333:RNA, Messenger / Q000378:metabolism
chemical_list: D012333:RNA, Messenger; D003541:Cystathionine beta-Synthase; D003542:Cystathionine gamma-Lyase; D006862:Hydrogen Sulfide