title: [Pancreatic functional status after wedge resection of the duodenal wall and para-pancreatic micro-irrigation].
abstract: OBJECTIVE
  To study influence parapancreatic microirrigation on morphological and functional condition of a pancreas and transformations of enzymatic activity of blood serum and enzymatic activity of lymph of a chest lymphatic channel after an operative trauma of a duodenum.
  
  
  METHODS
  Research is executed on 140 not purebred dogs which have been divided into six groups and united in two series. In the first series (30 dogs) were studied changes pancreatic exosecretion in the postoperative period of resection of duodenum (group 1.1), in the postoperative period of resection of duodenum with preliminary infiltration of a parapancreatic tissue of 0.5% by a solution of Novocain (group 1.2) and after resection of duodenum with application parapancreatic microirrigation (group 1.3). In the second series (110 dogs) were studied frequency of development of acute pancreatitis, enzymatic activity of blood serum and enzymatic activity of lymph of thoracal lymphatic duct after resection of duodenum (group 2.1) and in the postoperative period of resection of duodenum with preliminary infiltration of a parapancreatic tissue of 0.5% by a solution of Novocain (group 2.2) and after resection of duodenum with application parapancreatic microirrigation (group 2.3).
  
  
  RESULTS
  Application parapancreatic microirrigation does not lead to oppression pancreatic exosecretion at the first o'clock after duodenotomy, and substantially reduces the pancreatic hypersecretion observed in the postoperative period of resection of a duodenum. In addition, application parapancreatic microirrigation reduces frequency of development of acute pancreatitis and promotes less expressed increase enzymatic activity of blood serum and enzymatic activity of lymph thoracal lymphatic duct at development of the given complication after operational trauma of duodenum in comparison with resection of duodenum and after a resection of a duodenum executed against infiltration of a parapancreatic tissue of 0.5% by a solution of Novocain.
authors.forename: S E
authors.initials: SE
authors.lastname: Voskanian
authors.forename: E V
authors.initials: EV
authors.lastname: Naĭdenov
mesh_terms: D000208:Acute Disease; D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D004386:Duodenum / Q000293:injuries*; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives / Q000627:therapeutic use; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism* / Q000473:pathology; D010186:Pancreatic Function Tests; D010195:Pancreatitis / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D011183:Postoperative Complications / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D007507:Therapeutic Irrigation
chemical_list: D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-