title: [Successful early treatment in a case of Cogan's syndrome].
abstract: We report a 53-year-old male with Cogan's syndrome. He was admitted to our hospital because of a fever of 2-weeks duration, blurred vision for 10 days, hypoacusis, and numbness of the left hand for 3 days. In addition to uveitis, hypoacusis, and aseptic meningitis, multiple mononeuropathy was diagnosed based on a nerve conduction study. Furthermore, positron emission tomography/computed tomography (PET/CT) revealed diffuse aortitis. Accordingly, the patient was diagnosed with Cogan's syndrome. After starting steroid-pulse therapy followed by 1 mg oral prednisolone/kg/day, the uveitis and hypoacusis improved immediately, while the peripheral neuropathy persisted until effectively treated with intravenous gamma globulin therapy. Prompt steroid therapy for Cogan's syndrome based on a diagnosis made using PET/CT prevented progression of the hypoacusis.
authors.affiliation: Division of Rheumatic Diseases, National Center for Global Health and Medicine.
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Tsuno
authors.forename: Yuko
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Yoshida
authors.forename: Naotoshi
authors.initials: N
authors.lastname: Arai
authors.forename: Yousuke
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Seiko
authors.initials: S
authors.lastname: Yashiro
authors.forename: Masami
authors.initials: M
authors.lastname: Makizumi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Yamashita
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kaneko
authors.forename: Toshikazu
authors.initials: T
authors.lastname: Kano
authors.forename: Akio
authors.initials: A
authors.lastname: Mimori
mesh_terms: D055952:Cogan Syndrome / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D061345:Early Medical Intervention; D006801:Humans; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed