title: Mutual co-regulation between GPI-N-acetylglucosaminyltransferase and ergosterol biosynthesis in Candida albicans.
abstract: A novel co-regulation exists between the first step of GPI (glycosylphosphatidylinositol) anchor biosynthesis and the rate-determining step of ergosterol biosynthesis in Candida albicans. Depleting CaGpi19p, an accessory subunit of the enzyme complex that initiates GPI biosynthesis, down-regulates ERG11, altering ergosterol levels and drug response. This effect is specific to CaGpi19p depletion and is not due to cell wall defects or GPI deficiency. Additionally, down-regulation of ERG11 down-regulates CaGPI19 and GPI biosynthesis.
authors.affiliation: School of Life Sciences, Jawaharlal Nehru University, New Delhi 110067, India.
authors.forename: Guiliana Soraya
authors.initials: GS
authors.lastname: Victoria
authors.forename: Bhawna
authors.initials: B
authors.lastname: Yadav
authors.forename: Lalremruata
authors.initials: L
authors.lastname: Hauhnar
authors.forename: Priyanka
authors.initials: P
authors.lastname: Jain
authors.forename: Shilpi
authors.initials: S
authors.lastname: Bhatnagar
authors.forename: Sneha Sudha
authors.initials: SS
authors.lastname: Komath
mesh_terms: D002176:Candida albicans / Q000201:enzymology / Q000378:metabolism*; D015536:Down-Regulation; D004875:Ergosterol / Q000096:biosynthesis*; D058851:GPI-Linked Proteins / Q000378:metabolism*; D008401:Gas Chromatography-Mass Spectrometry; D017351:N-Acetylglucosaminyltransferases / Q000378:metabolism*; D060888:Real-Time Polymerase Chain Reaction
chemical_list: D058851:GPI-Linked Proteins; D017351:N-Acetylglucosaminyltransferases; C037649:N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase; D004875:Ergosterol