title: Immunohistochemical findings of an autopsied lung specimen from a patient with pandemic influenza (A/H1N1pdm) virus infection.
abstract: A 24-year-old female presented with fever and dry cough. Influenza A virus infection was suspected and the patient was treated with neuraminidase inhibitors. Five days after diagnosis, the patient developed persistent fever and dyspnea, and was diagnosed with severe pneumonia. Despite intensive treatment, the pneumonia worsened and the patient died 14 days after admission. At autopsy, a diffuse alveolar damage (DAD) pattern was observed. Immunohistochemical evaluation indicated severe epithelial damage, resulting in successive regeneration of alveolar type II cells followed by marked proliferation of smooth muscle cells and an increase of collagen fibers at the tip of alveolar orifices.
authors.affiliation: Department of Infectious, Respiratory, and Digestive Medicine, Control and Prevention of Infectious Diseases (The First Department of Internal Medicine), Faculty of Medicine, University of the Ryukyus, Japan. fujita@med.u-ryukyu.ac.jp
authors.forename: Jiro
authors.initials: J
authors.lastname: Fujita
authors.forename: Hajime
authors.initials: H
authors.lastname: Higa
authors.forename: Masato
authors.initials: M
authors.lastname: Azuma
authors.forename: Meika
authors.initials: M
authors.lastname: Kin
authors.forename: Koichiro
authors.initials: K
authors.lastname: Kakazu
authors.forename: Masahiko
authors.initials: M
authors.lastname: Toume
authors.forename: Iwao
authors.initials: I
authors.lastname: Nakazato
authors.forename: Haley L
authors.initials: HL
authors.lastname: Cash
authors.forename: Futoshi
authors.initials: F
authors.lastname: Higa
authors.forename: Masao
authors.initials: M
authors.lastname: Tateyama
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Tsutsumi
authors.forename: Yuji
authors.initials: Y
authors.lastname: Ohtsuki
mesh_terms: D001344:Autopsy; D049109:Cell Proliferation; D003094:Collagen / Q000378:metabolism; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000302:isolation & purification*; D007251:Influenza, Human / Q000453:epidemiology* / Q000378:metabolism / Q000473:pathology*; D007564:Japan; D008168:Lung / Q000378:metabolism / Q000473:pathology* / Q000821:virology*; D032389:Myocytes, Smooth Muscle / Q000473:pathology; D058873:Pandemics; D011650:Pulmonary Alveoli / Q000378:metabolism / Q000473:pathology / Q000821:virology; D055815:Young Adult
chemical_list: D003094:Collagen