title: Social isolation produces anxiety-like behaviors and changes PSD-95 levels in the forebrain.
abstract: Isolation rearing induces profound behavioral and neurochemical abnormalities in rodents. However there have been many controversies with its anxiogenic-like effects using models like elevated-plus maze. In the current study we aimed to address this by using one novelty-based anxiety paradigm that has been largely overlooked in previous isolation rearing studies. We found that eight-week isolation rearing produced potent anxiogenic-like effects in novelty-induced hypophagia test in mice. We also demonstrated PSD-95 levels were elevated in the hippocampus and amygdala and reduced in the frontal cortex after social isolation. This study provides further behavioral and neurochemical evidence to support that isolation rearing can produce anxiogenic-like effects in rodents.
authors.affiliation: Institute of Pharmacy and Pharmacology, University of South China, Hengyang, Hunan 421001, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xuyu
authors.initials: X
authors.lastname: Zu
authors.forename: Weishi
authors.initials: W
authors.lastname: Luo
authors.forename: Hongwei
authors.initials: H
authors.lastname: Yang
authors.forename: Guoxuan
authors.initials: G
authors.lastname: Luo
authors.forename: Mengxia
authors.initials: M
authors.lastname: Zhang
authors.forename: Shengsong
authors.initials: S
authors.lastname: Tang
mesh_terms: D000818:Animals; D001007:Anxiety / Q000378:metabolism*; D001522:Behavior, Animal / Q000502:physiology*; D000076122:Disks Large Homolog 4 Protein; D004435:Eating / Q000502:physiology; D005106:Exploratory Behavior / Q000502:physiology; D051528:Guanylate Kinases / Q000378:metabolism*; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D016548:Prosencephalon / Q000378:metabolism*; D012934:Social Isolation
chemical_list: D000076122:Disks Large Homolog 4 Protein; C501447:Dlg4 protein, mouse; D008565:Membrane Proteins; D051528:Guanylate Kinases