title: Synthesis and structure elucidation of five new conjugates of oleanolic acid derivatives and chalcones using 1D and 2D NMR spectroscopy.
abstract: Five new conjugates of oleanolic acid derivatives and chalcones have been designed and synthesized. The structure elucidation of these conjugates was accomplished by using extensive 1D ((1)H, (13)C) and 2D NMR spectroscopic studies (COSY, HSQC and HMBC); and α-glucosidase inhibitory activity is reported for these conjugates. Compound 2b (IC(50)  = 47.5 µm) displayed much stronger activity than oleanolic acid and acarbose.
authors.affiliation: Laboratory for Natural Product Chemistry, College of Pharmacy, South Central University for Nationalities, 708 Minyuan Road, Wuhan 430074, China.
authors.forename: Chu
authors.initials: C
authors.lastname: Tang
authors.forename: Linhui
authors.initials: L
authors.lastname: Zhu
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Rui
authors.initials: R
authors.lastname: Qin
authors.forename: Chang
authors.initials: C
authors.lastname: Liu
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.forename: Guangzhong
authors.initials: G
authors.lastname: Yang
mesh_terms: D002247:Carbon Isotopes; D047188:Chalcones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D003903:Deuterium; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D065089:Glycoside Hydrolase Inhibitors; D015394:Molecular Structure; D009828:Oleanolic Acid / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D011522:Protons; D013329:Structure-Activity Relationship; D000520:alpha-Glucosidases / Q000378:metabolism
chemical_list: D002247:Carbon Isotopes; D047188:Chalcones; D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D011522:Protons; D009828:Oleanolic Acid; D003903:Deuterium; D000520:alpha-Glucosidases