title: The importance of cardiac biomarkers on remodelling after myocardial infarction.
abstract: BACKGROUND
  The purpose of this study is to evaluate the importance of tenascin-C ( TNC), N-terminal pro brain natriuretic peptide (NT-proBNP) and C-reactive protein (CRP) on LV remodelling after myocardial infarction (MI).
  
  
  METHODS
  Fifty-seven stable patients with subacute anterior MI who had total or subtotal occlusion in the infarct-related left anterior desending artery in coronary angiography were enrolled the study. 18 of patients who had total occlusion received only medical theraphy, 19 of patients who had total occlusion received successful PCI+ medical theraphy and 20 of patients who had subtotal occlusion received successful PCI+ medical theraphy. Left ventricular volumes and ejection fractions (EF) were measured with echocardiography. Serum TNC, NT-proBNP and CRP levels were measured at admission and a month after treatment.
  
  
  RESULTS
  There was significant increase in LV end-diastolic volume (LVEDV) and LV end-systolic volume (LVESV) baseline to follow-up in total-PCI group. Baseline to follow-up; a borderline significant increase was observed in LVEDV in the total-medical group. No significant difference was seen in LV volumes and EF in the subtotal-PCI group. NT-proBNP, TNC and CRP levels were decreased in all groups. The decrease in NT-proBNP and CRP values were significant in the total-medical and subtotal-PCI group but in the total-PCI group they were not significant. The decrease of TNC was significant in all groups but the lowest decrease was seen in the total-PCI group.
  
  
  CONCLUSIONS
  TNC, NT-proBNP and CRP reflect LV remodelling in accordance with echocardiography after MI.
  
  
  BACKGROUND
  Tenascin-C; NT-pro BNP; CRP; Remodelling; Myocardial infarction.
authors.affiliation: Department of Cardiology, Elazig Education and Research Hospital, Elazig, Turkey.
authors.forename: Ahmet
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authors.lastname: Celik
authors.forename: Nihat
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authors.lastname: Kalay
authors.forename: Omer
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authors.lastname: Sahin
authors.forename: Mustafa
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authors.lastname: Duran
authors.forename: Hasan
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authors.lastname: Korkmaz
authors.forename: Mehmet Ali
authors.initials: MA
authors.lastname: Kobat
authors.forename: Ertugrul
authors.initials: E
authors.lastname: Kurtoglu
authors.forename: Ali
authors.initials: A
authors.lastname: Dogan
authors.forename: Sabahattin
authors.initials: S
authors.lastname: Muhtaroglu
authors.forename: Oguzhan
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authors.lastname: Baran
authors.forename: Mehmet Tugrul
authors.initials: MT
authors.lastname: Inanc
authors.forename: Ibrahim
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authors.lastname: Ozdogru
authors.forename: Abdurrahman
authors.initials: A
authors.lastname: Oguzhan
authors.forename: Ramazan
authors.initials: R
authors.lastname: Topsakal