title: Amino Acid Substitutions in the Caenorhabditis elegans RNA Polymerase II Large Subunit AMA-1/RPB-1 that Result in α-Amanitin Resistance and/or Reduced Function.
abstract: Mutations in the Caenorhabditis elegans RNA polymerase II AMA-1/RPB-1 subunit that cause α-amanitin resistance and/or developmental defects were isolated previously. We identified 12 of these mutations and mapped them onto the Saccharomyces cerevisiae RPB1 structure to provide insight into AMA-1 regions that are essential for development in a multicellular organism.
authors.forename: Elizabeth Anne
authors.initials: EA
authors.lastname: Bowman
authors.forename: Donald L
authors.initials: DL
authors.lastname: Riddle
authors.forename: William
authors.initials: W
authors.lastname: Kelly