title: Design of iron chelators with therapeutic application.
abstract: Iron is essential for the proper functioning of all living cells, however it is toxic when present in excess. Thus, using iron chelators as therapeutic agents, namely chelation therapy, has received increasing attention. The objective of this review is to discuss the factors which should be considered when designing clinically useful iron chelators, to present the application of iron chelators in the treatment of iron overload associated with β-thalassaemia major and sickle cell anaemia, and to highlight the potential applications in the treatment of neurodegenerative disorders and microbial infection. This article reviews recent knowledge centred on these themes and indicates the growing importance of the concept of iron chelation in medicine.
authors.affiliation: School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou, Zhejiang 310012, P R China.
authors.forename: Tao
authors.initials: T
authors.lastname: Zhou
authors.forename: Yongmin
authors.initials: Y
authors.lastname: Ma
authors.forename: Xiaole
authors.initials: X
authors.lastname: Kong
authors.forename: Robert C
authors.initials: RC
authors.lastname: Hider
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use; D015195:Drug Design; D006801:Humans; D007502:Iron Chelating Agents / Q000009:adverse effects / Q000737:chemistry / Q000378:metabolism / Q000627:therapeutic use*; D019190:Iron Overload / Q000150:complications / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents; D007502:Iron Chelating Agents