title: Elevated serum Bcl-2 in children with temporal lobe epilepsy.
abstract: Intractable temporal lobe epilepsy (TLE) is associated with alterations in expression of apoptosis-associated signaling molecules in the temporal lobe. Bcl-2 is an anti-apoptotic molecule which has previously been reported to be raised in patient's brain and serum. In the present study we examined serum Bcl-2 protein levels as a surrogate marker of apoptosis-associated signaling in children with non lesional TLE. Serum Bcl-2 levels were found to be higher in patients with TLE than controls. The serum level correlated to seizure variables including, duration of disease, frequency of seizures, and disease severity. The impact of epilepsy on cognition was assessed using total score intelligence quotient (IQ). IQ was found to be lower than controls and negatively correlated to serum Bcl-2. These findings support serum Bcl-2 levels as a marker of seizure burden and cognition in children with epilepsy.
authors.affiliation: Department of Research on Children with Special Needs, National Research Center, Egypt.
authors.forename: Ayman
authors.initials: A
authors.lastname: Kilany
authors.forename: Ehab R Abdel
authors.initials: ER
authors.lastname: Raouf
authors.forename: Ahmed A
authors.initials: AA
authors.lastname: Gaber
authors.forename: Taha Kamel
authors.initials: TK
authors.lastname: Aloush
authors.forename: Hany A
authors.initials: HA
authors.lastname: Aref
authors.forename: Mona
authors.initials: M
authors.lastname: Anwar
authors.forename: David C
authors.initials: DC
authors.lastname: Henshall
authors.forename: M Osama
authors.initials: MO
authors.lastname: Abdulghani
mesh_terms: D000293:Adolescent; D017209:Apoptosis / Q000502:physiology; D015415:Biomarkers / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D004833:Epilepsy, Temporal Lobe / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000097:blood*
chemical_list: D015415:Biomarkers; D019253:Proto-Oncogene Proteins c-bcl-2