title: Study on cytotoxicity and structure-activity relationship of HL-7702 cell exposed to naphthoquinones.
abstract: The acute cytotoxicities of six naphthoquinone compounds, including Atovaquone, Buparvaquone, Menadione, 2-acetoxy-1,4-naphthoquinone and 2-ethoxy-1,4-naphthoquinone, to HL-7702 cells were determined. The results showed that the toxicities of these naphthoquinones were characterized by a steep response pattern except for 2-hydroxy-1,4-naphthoquinone. Meanwhile, the cellular injuries were unrecoverable. Several molecular descriptors, such as the octanol-water partition coefficients (LogP), diameter (Dia) and topological index (TIndx), played an important role in the toxicity of naphthoquinones to HL-7702 cell. Our results provide a foundation for further investigation using 3D-QSAR and HQSAR to evaluate the aquatic ecological risk and the possible mechanisms of toxicity of naphthoquinones.
authors.affiliation: School of Environmental and Chemical Engineering, Tianjin Polytechnic University, Xiqing District, Tianjin, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Guo
authors.forename: Wenhua
authors.initials: W
authors.lastname: Song
authors.forename: Feng
authors.initials: F
authors.lastname: Ding
authors.forename: Jinyang
authors.initials: J
authors.lastname: Zhang
authors.forename: Zengtian
authors.initials: Z
authors.lastname: Sun
mesh_terms: D020003:1-Octanol / Q000737:chemistry; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004785:Environmental Pollutants / Q000633:toxicity*; D006801:Humans; D009285:Naphthoquinones / Q000737:chemistry / Q000633:toxicity*; D013329:Structure-Activity Relationship; D014867:Water / Q000737:chemistry
chemical_list: D004785:Environmental Pollutants; D009285:Naphthoquinones; D014867:Water; D020003:1-Octanol