title: Hydroxyapatite-armored poly(ε-caprolactone) microspheres and hydroxyapatite microcapsules fabricated via a Pickering emulsion route.
abstract: Hydroxyapatite (HAp) nanoparticle-armored poly(ε-caprolactone) (PCL) microspheres were fabricated via a "Pickering-type" emulsion solvent evaporation method in the absence of any molecular surfactants. It was clarified that the interaction between carbonyl/carboxylic acid groups of PCL and the HAp nanoparticles at an oil-water interface played a crucial role in the preparation of the stable Pickering-type emulsions and the HAp nanoparticle-armored microspheres. The HAp nanoparticle-armored PCL microspheres were characterized in terms of size, size distribution, morphology, and chemical compositions using scanning electron microscopy, laser diffraction, energy dispersive X-ray microanalysis, and thermogravimetric analysis. The presence of HAp nanoparticles at the surface of the microspheres was confirmed by scanning electron microscopy and energy dispersive X-ray microanalysis. Pyrolysis of the PCL cores led to the formation of the corresponding HAp hollow microcapsules.
authors.affiliation: Department of Applied Chemistry, Faculty of Engineering, Osaka Institute of Technology, 5-16-1 Ohmiya, Asahi-ku, Osaka 535-8585, Japan. s.fujii@chem.oit.ac.jp
authors.forename: Syuji
authors.initials: S
authors.lastname: Fujii
authors.forename: Masahiro
authors.initials: M
authors.lastname: Okada
authors.forename: Taiki
authors.initials: T
authors.lastname: Nishimura
authors.forename: Hayata
authors.initials: H
authors.lastname: Maeda
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Sugimoto
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Hamasaki
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Furuzono
authors.forename: Yoshinobu
authors.initials: Y
authors.lastname: Nakamura
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis*; D002214:Capsules; D003890:Desiccation; D017886:Durapatite / Q000737:chemistry*; D004577:Electron Probe Microanalysis; D004655:Emulsions / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D053758:Nanoparticles / Q000737:chemistry; D009821:Oils / Q000737:chemistry; D010316:Particle Size; D011091:Polyesters / Q000737:chemistry*; D013818:Thermogravimetry; D014867:Water / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D002214:Capsules; D004655:Emulsions; D009821:Oils; D011091:Polyesters; D014867:Water; C016240:polycaprolactone; D017886:Durapatite