title: A preliminary study on the effect of manuka honey on second-intention healing of contaminated wounds on the distal aspect of the forelimbs of horses.
abstract: OBJECTIVE
  To determine the effect of manuka honey on second-intention healing of contaminated, full-thickness skin wounds in horses.
  
  
  METHODS
  Experimental.
  
  
  METHODS
  Adult Standardbred horses (n = 8).
  
  
  METHODS
  One wound was created on the dorsomedial aspect of the third metacarpus in both forelimbs, contaminated with feces, and bandaged for 24 hours. Bandages were removed and wounds rinsed with isotonic saline solution. Wounds on 1 limb had manuka honey applied daily (n = 8) whereas wounds on the contralateral limb received no treatment (n = 8). Bandages were replaced and changed daily for 12 days, after which treatment stopped, bandages were removed, leaving wounds open to heal. Wound area was measured 24 hours after wound creation (day 1), then weekly for 8 weeks. Overall time for healing was recorded. Wound area and rate of healing of treated and control wounds were compared statistically.
  
  
  RESULTS
  Treatment with manuka honey decreased wound retraction and treated wounds remained significantly smaller than control wounds until day 42; however, there was no difference in overall healing time between treatment and control wounds.
  
  
  CONCLUSIONS
  Treatment with manuka honey reduced wound area by reducing retraction but did not affect overall healing time of full-thickness distal limb wounds using this wound-healing model.
authors.affiliation: Biomedical Research and Clinical Trials Unit, University Veterinary Teaching Hospital, University of Sydney, Camden, Australia.
authors.forename: Andrea S
authors.initials: AS
authors.lastname: Bischofberger
authors.forename: Christina M
authors.initials: CM
authors.lastname: Dart
authors.forename: Nigel R
authors.initials: NR
authors.lastname: Perkins
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Dart
mesh_terms: D000818:Animals; D005552:Forelimb; D006722:Honey; D006734:Horse Diseases / Q000628:therapy*; D006736:Horses; D008297:Male; D013997:Time Factors; D014945:Wound Healing; D014947:Wounds and Injuries / Q000628:therapy / Q000662:veterinary*