title: Synthesis and characterization of G5 PAMAM dendrimer containing daunorubicin for targeting cancer cells.
abstract: A multifunctional dendritic nanodevice containing folate (FA) as the targeting molecule and daunorubicin (DNR) as the chemotherapeutic drug has been designed and synthesized. The primary amino groups on the surface of the generation 5 poly(amidoamine) dendrimer (G5 dendrimer) were acetylated partially. FA and DNR were conjugated to the remaining primary amino groups on the G5 dendrimer through amide and ester linkage, respectively, to generate the difunctional dendritic device. The synthetic approach of G5 PAMAM dendrimer containing daunorubicin and folic acid would be useful for targeting the overexpressed membrance-associated folate receptors of KB human carcinoma cell line and discreating them effectively.
authors.affiliation: College of Pharmacy, Woosuk University, Wanju 565-701, Korea.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Yue
authors.forename: Jae Soon
authors.initials: JS
authors.lastname: Eun
authors.forename: Mi-Kyung
authors.initials: MK
authors.lastname: Lee
authors.forename: Seung-Yong
authors.initials: SY
authors.lastname: Seo
mesh_terms: D003630:Daunorubicin / Q000737:chemistry* / Q000627:therapeutic use; D050091:Dendrimers / Q000138:chemical synthesis* / Q000737:chemistry*; D004337:Drug Carriers / Q000138:chemical synthesis* / Q000737:chemistry* / Q000627:therapeutic use; D005492:Folic Acid / Q000737:chemistry; D006801:Humans; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy
chemical_list: D050091:Dendrimers; D004337:Drug Carriers; D005492:Folic Acid; D003630:Daunorubicin