title: Cytisine: a natural product lead for the development of drugs acting at nicotinic acetylcholine receptors.
abstract: Covering: up to the end of 2011. This review covers classical and modern structural modifications of the alkaloid, the more recent (since 2007) syntheses of cytisine and analogues, and the pharmacology of these compounds, with emphasis on their interactions with nicotinic receptors. 89 references are cited.
authors.affiliation: Millennium Institute for Cell Dynamics and Biotechnology, Santiago, Chile.
authors.forename: Edwin G
authors.initials: EG
authors.lastname: Pérez
authors.forename: Carolina
authors.initials: C
authors.lastname: Méndez-Gálvez
authors.forename: Bruce K
authors.initials: BK
authors.lastname: Cassels
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D001392:Azocines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001688:Biological Products / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D011807:Quinolizines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D011978:Receptors, Nicotinic / Q000187:drug effects*; D000093843:Quinolizidine Alkaloids
chemical_list: D000470:Alkaloids; D001392:Azocines; D001688:Biological Products; D011807:Quinolizines; D011978:Receptors, Nicotinic; C004712:cytisine; D000093843:Quinolizidine Alkaloids