title: [Cytogenetic diagnosis of first trimester spontaneous abortion].
abstract: BACKGROUND
  About 15% of all pregnancies end in abortion. In approximately 60% of all losses are chromosomal abnormalities as a cause of pregnancy loss.
  
  
  OBJECTIVE
  To determine the importance of cytogenetic study in patients with spontaneous abortion.
  
  
  METHODS
  A series of cases of women diagnosed with spontaneous abortion less than 12 weeks and cytogenetic studies. Two groups, one group of women with normal cytogenetics and group 2 patients with abnormal cytogenetic result. 44 patients were excluded by cytogenetic study failed.
  
  
  RESULTS
  We included 164 women, 55 and 65 for groups 1 and 2, respectively. In 44 cases the material was not suitable for performing karyotype. Of the 120 cases included, had abnormal karyotypes in 65 cases (54%), of which 34 cases (52.3%) were trisomy, 16 cases (24.6%) to polyploidy and 9 cases (13.8%) a monosomy. In addition, we found six cases (8.7%) with recurrent pregnancy loss. The maternal age limit increased incidence of chromosomal abnormalities occurred in the group of 31 and 35 years with 20 cases (30%). Of trisomies, the 16 were the mostfrequent with 11 cases (32.3%).
  
  
  CONCLUSIONS
  The finding of 54% of chromosomal abnormalities in spontaneous abortion products demonstrates the importance of cytogenetic study, regardless of patient age and number of previous pregnancy losses.
authors.affiliation: Hefe de Servicio de Ginecologia y Obstetricia, Fundación Clínica Médica Sur.
authors.forename: Angel García
authors.initials: AG
authors.lastname: Alonso López
authors.forename: Sara
authors.initials: S
authors.lastname: Bermejo Huerta
authors.forename: Rafael
authors.initials: R
authors.lastname: Hernández Galván
authors.forename: Roberto
authors.initials: R
authors.lastname: AyalaPosadas
authors.forename: Ariadna
authors.initials: A
authors.lastname: González del Angel
authors.forename: Patricia Grether
authors.initials: PG
authors.lastname: González
mesh_terms: D000022:Abortion, Spontaneous / Q000175:diagnosis* / Q000235:genetics*; D000328:Adult; D003430:Cross-Sectional Studies; D020732:Cytogenetic Analysis; D005260:Female; D006801:Humans; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D012189:Retrospective Studies; D055815:Young Adult