title: [Methylphenidate misuse].
abstract: Methylphenidate (MPH) is mainly used for treatment of the attention-deficit hyperactivity syndrome (ADHS). Non-medical use of methylphenidate as recreational drug or performance enhancer has increased in recent years. Methylphenidate is also misused in combination with other drugs. Patients with ADHD are also at risk to misuse their prescribed methylphenidate medication. Oral and nasal abuse of methylphenidate is most common and is in general associated with minor or moderate sympathomimetic toxicity. In contrast, severe toxicity has been reported for both intravenous and intraarterial administration of crushed methylphenidate tablets.
authors.affiliation: Abteilung für Klinische Pharmakologie und Toxikologie, Universitätsspital Basel.
authors.forename: M
authors.initials: M
authors.lastname: Bruggisser
authors.forename: M
authors.initials: M
authors.lastname: Bodmer
authors.forename: M E
authors.initials: ME
authors.lastname: Liechti
mesh_terms: D001289:Attention Deficit Disorder with Hyperactivity / Q000097:blood / Q000188:drug therapy; D000697:Central Nervous System Stimulants / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use; D003430:Cross-Sectional Studies; D006801:Humans; D015994:Incidence; D008657:Metabolic Clearance Rate / Q000502:physiology; D008774:Methylphenidate / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use; D019966:Substance-Related Disorders / Q000097:blood / Q000453:epidemiology*; D013557:Switzerland
chemical_list: D000697:Central Nervous System Stimulants; D008774:Methylphenidate