title: Could hydrolysis of arsenic substituted DNA be prevented? Protection arises from stacking interactions.
abstract: Investigation of the hydrolysis of dinucleoside-arsenate-deoxyguanylyl-3',5'-deoxyguanosine (dGAsdG(-)) reveals that base-stacking in DNA increases the resistance of As-DNA towards hydrolysis. Base-stacking raises the activation energy of hydrolysis. Hydrolysis of As-DNA is found to be endothermic. The hydrolysis stability of As-DNA should be higher than that estimated based on arsenate diester models.
authors.affiliation: Interdisciplinary Nanotoxicity Center, Department of Chemistry and Biochemistry, Jackson State University, Jackson, MS 39217, USA.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Jiande
authors.initials: J
authors.lastname: Gu
authors.forename: Jerzy
authors.initials: J
authors.lastname: Leszczynski
mesh_terms: D001149:Arsenates / Q000737:chemistry*; D001151:Arsenic / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D015226:Dinucleoside Phosphates / Q000737:chemistry*; D006868:Hydrolysis
chemical_list: D001149:Arsenates; D015226:Dinucleoside Phosphates; C034298:deoxyguanylyl-(3'-5')-guanosine; D004247:DNA; D001151:Arsenic; C025657:arsenic acid