title: Biomimetic assembly of proteins into microcapsules on oil-in-water droplets with structural reinforcement via biomolecular-recognition-based cross-linking of surface peptides.
abstract: By mimicking the stabilization of bacterial membranes with S-layer proteins, a novel process to fabricate highly stable protein microcapsules is introduced. In this strategy, engineered collagen peptides with site-specific biotinylation are assembled into microcapsules on the oil-in-water droplets, and the resulting microcapsules are reinforced by biomolecular-recognition-based cross-linking with the protein. Furthermore the microcapsules are shown to be versatile scaffolds for developing functionalized hierarchical colloidosomes for important biotechnological applications.
authors.affiliation: Department of Chemistry and Biochemistry, City University of New York (CUNY), Hunter College, New York, NY 10065, USA.
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Maeda
authors.forename: Zengyan
authors.initials: Z
authors.lastname: Wei
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Matsui
mesh_terms: D032701:Biomimetics; D002214:Capsules / Q000737:chemistry*; D003094:Collagen / Q000737:chemistry; D009821:Oils / Q000737:chemistry; D010455:Peptides / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*; D013499:Surface Properties; D014867:Water / Q000737:chemistry*
chemical_list: D002214:Capsules; D009821:Oils; D010455:Peptides; D011506:Proteins; D014867:Water; D003094:Collagen