title: Tetrahydrofuran cembranoids from the cultured soft coral Lobophytum crassum.
abstract: Three new cembranoids, culobophylins A-C (1-3), along with two known compounds (4 and 5) were isolated from the cultured soft coral Lobophytum crassum. The structures of these compounds were elucidated on the basis of their spectroscopic data and comparison of the NMR data with those of known analogues. Among these metabolites, 2 is rarely found in cembranoids possessing an isopropyl moiety with an epoxide group. Compound 1 exhibited significant cytotoxic activity against HL60 and DLD-1 cancer cell lines.
authors.affiliation: National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan.|Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan.
authors.forename: Nai-Lun
authors.initials: NL
authors.lastname: Lee
authors.affiliation: National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan.|Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan.
authors.forename: Jui-Hsin
authors.initials: JH
authors.lastname: Su
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000302:isolation & purification*; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005663:Furans / Q000302:isolation & purification; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D051379:Mice
chemical_list: D000970:Antineoplastic Agents; D004224:Diterpenes; D005663:Furans; C018674:tetrahydrofuran