title: Exploiting magnetic resonance angiography imaging improves model estimation of BOLD signal.
abstract: The change of BOLD signal relies heavily upon the resting blood volume fraction ([Formula: see text]) associated with regional vasculature. However, existing hemodynamic data assimilation studies pretermit such concern. They simply assign the value in a physiologically plausible range to get over ill-conditioning of the assimilation problem and fail to explore actual [Formula: see text]. Such performance might lead to unreliable model estimation. In this work, we present the first exploration of the influence of [Formula: see text] on fMRI data assimilation, where actual [Formula: see text] within a given cortical area was calibrated by an MR angiography experiment and then was augmented into the assimilation scheme. We have investigated the impact of [Formula: see text] on single-region data assimilation and multi-region data assimilation (dynamic cause modeling, DCM) in a classical flashing checkerboard experiment. Results show that the employment of an assumed [Formula: see text] in fMRI data assimilation is only suitable for fMRI signal reconstruction and activation detection grounded on this signal, and not suitable for estimation of unobserved states and effective connectivity study. We thereby argue that introducing physically realistic [Formula: see text] in the assimilation process may provide more reliable estimation of physiological information, which contributes to a better understanding of the underlying hemodynamic processes. Such an effort is valuable and should be well appreciated.
authors.affiliation: State Key Laboratory of Modern Optical Instrumentation, Zhejiang University, Hangzhou, China.
authors.forename: Zhenghui
authors.initials: Z
authors.lastname: Hu
authors.forename: Cong
authors.initials: C
authors.lastname: Liu
authors.forename: Pengcheng
authors.initials: P
authors.lastname: Shi
authors.forename: Huafeng
authors.initials: H
authors.lastname: Liu
mesh_terms: D000465:Algorithms; D000792:Angiography / Q000379:methods; D002138:Calibration; D006439:Hemodynamics; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D015233:Models, Statistical; D017711:Nonlinear Dynamics; D010100:Oxygen / Q000097:blood*; D012044:Regression Analysis; D015203:Reproducibility of Results; D012815:Signal Processing, Computer-Assisted
chemical_list: D010100:Oxygen