title: How SNARE molecules mediate membrane fusion: recent insights from molecular simulations.
abstract: SNARE molecules are the core constituents of the protein machinery that facilitate fusion of synaptic vesicles with the presynaptic plasma membrane, resulting in the release of neurotransmitter. On a molecular level, SNARE complexes seem to play a quite versatile and involved role during all stages of fusion. In addition to merely triggering fusion by forcing the opposing membranes into close proximity, SNARE complexes are now seen to also overcome subsequent fusion barriers and to actively guide the fusion reaction up to the expansion of the fusion pore. Here, we review recent advances in the understanding of SNARE-mediated membrane fusion by molecular simulations.
authors.affiliation: Theoretical Molecular Biophysics Group, Max-Planck-Institute for Biophysical Chemistry, Göttingen, Germany.
authors.forename: Herre Jelger
authors.initials: HJ
authors.lastname: Risselada
authors.forename: Helmut
authors.initials: H
authors.lastname: Grubmüller
mesh_terms: D008051:Lipid Bilayers / Q000737:chemistry / Q000378:metabolism; D008561:Membrane Fusion; D056004:Molecular Dynamics Simulation; D011485:Protein Binding; D050600:SNARE Proteins / Q000737:chemistry* / Q000378:metabolism
chemical_list: D008051:Lipid Bilayers; D050600:SNARE Proteins