title: HDAC6 at the Intersection of Neuroprotection and Neurodegeneration.
abstract: Histone deacetylase 6 (HDAC6) catalyzes multiple reactions. We summarize the current knowledge on HDAC6, its targets and functions. Among others, HDAC6 recognizes damaged proteins and assures that these proteins are destroyed by autophagy. On the other hand, HDAC6 also modifies the tracks used by the clearance mechanism so that axonal transport becomes less efficient. We hypothesize that a disturbance in the equilibrium between the different functions of HDAC6 could play an important role in neurodegeneration.
authors.affiliation: Vesalius Research Center, VIB, Campus Gasthuisberg, Leuven, Belgium.
authors.forename: Constantin
authors.initials: C
authors.lastname: d'Ydewalle
authors.forename: Elke
authors.initials: E
authors.lastname: Bogaert
authors.forename: Ludo
authors.initials: L
authors.lastname: Van Den Bosch
mesh_terms: D000107:Acetylation; D000818:Animals; D001343:Autophagy; D003599:Cytoskeleton / Q000378:metabolism; D015971:Gene Expression Regulation, Enzymologic; D000073864:Histone Deacetylase 6; D006655:Histone Deacetylases / Q000378:metabolism*; D006801:Humans; D008870:Microtubules / Q000378:metabolism; D008954:Models, Biological; D008957:Models, Genetic; D019636:Neurodegenerative Diseases / Q000378:metabolism*; D018696:Neuroprotective Agents / Q000494:pharmacology; D011485:Protein Binding; D011487:Protein Conformation; D025801:Ubiquitin / Q000378:metabolism
chemical_list: D018696:Neuroprotective Agents; D025801:Ubiquitin; C433811:HDAC6 protein, human; D000073864:Histone Deacetylase 6; D006655:Histone Deacetylases