title: Neutralization potential of the plasma of HIV-1 infected Indian patients in the context of anti-V3 antibody content and antiretroviral therapy. [corrected].
abstract: We assessed the anti-V3 antibody content and viral neutralization potential of the plasma of 63 HIV-1-infected patients (antiretroviral naïve=39, treated=24) against four primary isolates (PIs) of clade C and a tier 1 clade B isolate SF162. Depletion and inhibition of anti-V3 antibodies in the plasma of five patients with high titers of anti-V3 antibodies led to modest change in the neutralization percentage against two PIs (range 0-21%). The plasma of antiretroviral-treated patients exhibited higher neutralization potential than that of the drug-naïve plasmas against the four PIs tested which was further evidenced by a follow-up study.
authors.affiliation: Department of Biochemistry, All India Institute of Medical Sciences, 110029, New Delhi, India.
authors.forename: Alok Kumar
authors.initials: AK
authors.lastname: Choudhary
authors.forename: Raiees
authors.initials: R
authors.lastname: Andrabi
authors.forename: Somi Sankaran
authors.initials: SS
authors.lastname: Prakash
authors.forename: Rajesh
authors.initials: R
authors.lastname: Kumar
authors.forename: Shubhasree Dutta
authors.initials: SD
authors.lastname: Choudhury
authors.forename: Naveet
authors.initials: N
authors.lastname: Wig
authors.forename: Ashutosh
authors.initials: A
authors.lastname: Biswas
authors.forename: Anjali
authors.initials: A
authors.lastname: Hazarika
authors.forename: Kalpana
authors.initials: K
authors.lastname: Luthra
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage*; D057134:Antibodies, Neutralizing / Q000097:blood*; D005260:Female; D015483:HIV Antibodies / Q000097:blood*; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D009500:Neutralization Tests; D010949:Plasma / Q000276:immunology*
chemical_list: D019380:Anti-HIV Agents; D057134:Antibodies, Neutralizing; D015483:HIV Antibodies