title: [The long-term results of treatment of Ménière's disease with intratympanic injections of gentamicin].
abstract: OBJECTIVE
  To estimate the results of treatment of Ménière's disease with intratympanic injections of gentamicin.
  
  
  METHODS
  37 patients with defined, pharmacological treatment resistant Ménière's disease treated in Department of Otolaryngology and Laryngological Oncology of University of Medical Sciences in Poznań with intratympanic injections of gentamicin from 2001 to 2010 year.
  
  
  METHODS
  Patients were injected intratympanic with 0.3 ml (12 mg) of gentamicin once or few times with 7 days or longer breaks and a number of injections depended on the reaction of the inner ear. We estimated the patients' subjective feelings and results of equilibrium and hearing organ examination in early (3 months) and late (2 years) period after treatment.
  
  
  RESULTS
  Complete control of vertigo (class A) was achieved in 84.6%, and complete and essential control (class A and B) in 96.1%. Hearing deterioration usually mild or moderate was observed directly after treatment in 16.2% and after 2 years in 23% patients. The results of pure tone audiometry showed deterioration of hearing in 16.2% (early) and 26.9% (late). In 1 patient hearing deterioration was essential.
  
  
  CONCLUSIONS
  Intratympanic injections of gentamicin are effective and not troublesome method of treatment of pharmacological treatment resistant Ménière's disease. In most of patients hearing can be preserved, but they should be always informed about possible risk of hearing deterioration. The number of injections and breaks between them depends on the effect of therapy and of expectations of patients.
authors.affiliation: Klinika Otolaryngologii i Onkologii, Laryngologicznej Uniwersytetu Medycznego, w Poznaniu. wojgaw@interia.pl
authors.forename: Wojciech
authors.initials: W
authors.lastname: Gawęcki
authors.forename: Witold
authors.initials: W
authors.lastname: Szyfter
authors.forename: Joanna
authors.initials: J
authors.lastname: Lączkowska-Przybylska
authors.forename: Joanna
authors.initials: J
authors.lastname: Szyfter-Harris
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001299:Audiometry; D001301:Audiometry, Pure-Tone; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D005839:Gentamicins / Q000008:administration & dosage*; D006801:Humans; D015552:Injections, Intralesional; D008297:Male; D008575:Meniere Disease / Q000150:complications / Q000188:drug therapy*; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome; D014717:Vertigo / Q000188:drug therapy* / Q000209:etiology; D014724:Vestibular Function Tests
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins