title: Depressive symptoms and serum lipid levels in young adult women.
abstract: Accumulating data suggest that depression is associated with risk factors for cardiovascular disease, but few studies have investigated potential behavioral mediators of such associations, particularly among women. In this study of healthy young adult women (n = 225), we examined associations among depressive symptoms, health behaviors, and serum lipid levels. Depressive symptoms were assessed with the 20-item Center for Epidemiologic Studies-Depression scale, and a fasting blood sample was obtained for serum lipid levels, including total cholesterol, high-density lipoprotein (HDL-C) and low-density lipoprotein (LDL-C). Diet was measured using 24-h recalls, and other health behaviors (physical activity, smoking) were assessed via self-report questionnaire. Results indicated a modest negative association between depressive symptoms and LDL-C levels. Higher levels of depressive symptoms were also associated with lower total and insoluble dietary fiber intake, both of which were associated with HDL-C and LDL-C. Mediational analyses indicated a significant indirect effect of depressive symptoms on LDL-C via total and insoluble dietary fiber in unadjusted analyses, but not in adjusted analyses. The present findings suggest that depressive symptoms are inversely associated with serum LDL-C levels in young adult women, but that these associations are not likely mediated by adverse lifestyle behaviors.
authors.affiliation: Cancer Prevention and Control Program, Fox Chase Cancer Center, Robert C. Young Pavilion, 4th Floor, 333 Cottman Avenue, Philadelphia, PA 19111, USA. carolyn.fang@fccc.edu
authors.forename: Carolyn Y
authors.initials: CY
authors.lastname: Fang
authors.forename: Brian L
authors.initials: BL
authors.lastname: Egleston
authors.forename: Kelley Pettee
authors.initials: KP
authors.lastname: Gabriel
authors.forename: Victor J
authors.initials: VJ
authors.lastname: Stevens
authors.forename: Peter O
authors.initials: PO
authors.lastname: Kwiterovich
authors.forename: Linda G
authors.initials: LG
authors.lastname: Snetselaar
authors.forename: Margaret L
authors.initials: ML
authors.lastname: Longacre
authors.forename: Joanne F
authors.initials: JF
authors.lastname: Dorgan
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D003863:Depression / Q000097:blood* / Q000523:psychology*; D005260:Female; D005500:Follow-Up Studies; D015438:Health Behavior; D006801:Humans; D008019:Life Style; D055815:Young Adult
chemical_list: D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D002784:Cholesterol