title: Construction of a graphene oxide based noncovalent multiple nanosupramolecular assembly as a scaffold for drug delivery.
abstract: A multiple supramolecular assembly, in which a folic acid-modified β-cyclodextrin (1) acted as a target unit, an adamantanyl porphyrin (2) acted as a linker unit, and graphene oxide acted as a carrier unit, was successfully fabricated through non-covalent interactions and comprehensively investigated by means of UV/Vis, fluorescence, and X-ray photoelectron spectroscopies, and electron microscopy. Significantly, the graphene oxide unit could associate with the anticancer drug doxorubicin through π-π interactions, and the folic acid-modified β-cyclodextrin unit could recognize the folic acid receptors in cancer cells. Owing to the cooperative contribution of these three units, the resulting multiple supramolecular assembly, after association with doxorubicin, exhibited better drug activity and much lower toxicity than free doxorubicin in vivo.
authors.affiliation: Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin, 300071, PR China.
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.forename: Ying-Ming
authors.initials: YM
authors.lastname: Zhang
authors.forename: Yong
authors.initials: Y
authors.lastname: Chen
authors.forename: Di
authors.initials: D
authors.lastname: Zhao
authors.forename: Jia-Tong
authors.initials: JT
authors.lastname: Chen
authors.forename: Yu
authors.initials: Y
authors.lastname: Liu
mesh_terms: D016503:Drug Delivery Systems; D005492:Folic Acid / Q000737:chemistry; D006108:Graphite / Q000737:chemistry*; D006801:Humans; D010087:Oxides / Q000737:chemistry*; D011166:Porphyrins / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet; D047392:beta-Cyclodextrins / Q000737:chemistry
chemical_list: D010087:Oxides; D011166:Porphyrins; D047392:beta-Cyclodextrins; D006108:Graphite; D005492:Folic Acid