title: The clinical significance of autoantibodies to the proliferating cell nuclear antigen (PCNA).
abstract: Autoantibodies targeting the proliferating cell nuclear antigen (PCNA) were first described over 30 years ago and are historically most commonly associated with systemic lupus erythematosus (SLE). The primary antigenic target is a 34 kDa protein that is part of the DNA polymerase delta multi-protein complex. A number of diagnostic platforms have incorporated PCNA into their diagnostic assays and algorithms. However, little is known about the clinical utility of autoantibodies to PCNA, especially with novel detection systems. This review will focus on the history of the discovery of the PCNA autoantigen and the current status of the diagnostic significance of anti-PCNA and suggest future studies that are required to strengthen our understanding of their clinical utility.
authors.affiliation: INOVA Diagnostics, INC. San Diego, CA 32131-1638, USA. mmahler@inovadx.com
authors.forename: Michael
authors.initials: M
authors.lastname: Mahler
authors.forename: Kiyomitsu
authors.initials: K
authors.lastname: Miyachi
authors.forename: Carol
authors.initials: C
authors.lastname: Peebles
authors.forename: Marvin J
authors.initials: MJ
authors.lastname: Fritzler
mesh_terms: D000595:Amino Acid Sequence; D001323:Autoantibodies / Q000096:biosynthesis / Q000378:metabolism*; D001324:Autoantigens / Q000276:immunology / Q000302:isolation & purification / Q000378:metabolism; D001666:Binding Sites, Antibody; D019084:Fluorescent Antibody Technique, Indirect / Q000379:methods; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000276:immunology / Q000378:metabolism; D015201:Meta-Analysis as Topic; D008969:Molecular Sequence Data; D046912:Multiprotein Complexes / Q000276:immunology; D018809:Proliferating Cell Nuclear Antigen / Q000276:immunology* / Q000378:metabolism*
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D046912:Multiprotein Complexes; D018809:Proliferating Cell Nuclear Antigen