title: Comparative accuracy of CT attenuation-corrected and non-attenuation-corrected SPECT myocardial perfusion imaging.
abstract: OBJECTIVE
  The aim of the present study was to evaluate whether computed tomography based-attenuation correction (CT-AC) provides any advantage over non-attenuation-corrected (NAC) images for qualitative and quantitative analysis of single photon emission tomography (SPECT) myocardial perfusion imaging (MPI).
  
  
  METHODS
  We retrospectively evaluated data of 171 patients who underwent stress rest MPI SPECT/CT as per standard protocol. Angiography done within ±3 months of MPI was taken as reference standard. Two readers independently evaluated CT-AC and NAC images. Receiver operating characteristic curve analysis was done using ≥50% and ≥70% stenosis as cutoff. The size and severity of perfusion defects were also compared on CT-AC and NAC images.
  
  
  RESULTS
  For both readers, the area under the receiver operating characteristic curve was larger for CT-AC images than for NAC images at both ≥50% and ≥70% cutoff, but the difference was not significant. CT-AC images had significantly lower sensitivity for detecting right coronary artery disease compared with NAC (29% vs. 50% for reader 1 and 25.8% vs. 43.2% for reader 2). However, the specificity improved with CT-AC. Inferior defects were significantly smaller in CT-AC than NAC (P = 0.0002), with no significant difference for anterior defects (P = 0.544). There was significant variation in severity between CT-AC and NAC images for both overall (P = 0.001) as well as for inferior defects (P = 0.0007), but not for anterior defects (P = 0.279).
  
  
  CONCLUSIONS
  In our study, the CT-based AC improved the specificity but decreased the sensitivity leading to nonsignificant improvement in overall diagnostic accuracy of Tc-99m sestamibi/tetrofosmin MPI.
authors.affiliation: Department of Nuclear Medicine, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Punit
authors.initials: P
authors.lastname: Sharma
authors.forename: Chetan D
authors.initials: CD
authors.lastname: Patel
authors.forename: Sellam
authors.initials: S
authors.lastname: Karunanithi
authors.forename: Sagar
authors.initials: S
authors.lastname: Maharjan
authors.forename: Arun
authors.initials: A
authors.lastname: Malhotra
mesh_terms: D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008297:Male; D008875:Middle Aged; D055414:Myocardial Perfusion Imaging / Q000379:methods*; D012372:ROC Curve; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D014057:Tomography, X-Ray Computed