title: Partially saturated fluorinated heterocycles: diastereo- and enantioselective synthesis of β-trifluoromethyl-pyrroline carboxylates.
abstract: The first asymmetric synthesis of β-trifluoromethylated pyrroline carboxylates has been achieved by organocatalytic conjugated addition of adamantyl glycine imine to β-trifluoromethylated enones, followed by a deprotection/cyclization/dehydration sequence.
authors.affiliation: Department of Frontier Materials, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Nagoya 466-8555, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kawai
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Sugita
authors.forename: Etsuko
authors.initials: E
authors.lastname: Tokunaga
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Sato
authors.forename: Motoo
authors.initials: M
authors.lastname: Shiro
authors.forename: Norio
authors.initials: N
authors.lastname: Shibata
mesh_terms: D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D007097:Imines / Q000737:chemistry; D011758:Pyrroles / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D002264:Carboxylic Acids; D006845:Hydrocarbons, Fluorinated; D007097:Imines; D011758:Pyrroles