title: A new access to 3-substituted-1(2H)-isoquinolone by tandem palladium-catalyzed intramolecular aminocarbonylation annulation.
abstract: An original tribromide derivative based, palladium-catalyzed synthesis of 3-substituted-1(2H)-isoquinolone is described based on a regioselective Suzuki-Miyaura C-C coupling on o-halo-(2,2-dihalovinyl)-benzene followed by a palladium catalyzed amination-carbonylation-cyclization reaction. This sequence efficiently proceeds to build up isoquinolone in fair to good yields over a one-pot 3-bond synthesis reaction.
authors.affiliation: Institut Curie, Centre de Recherche, 26 rue d'Ulm, Paris 75248, France.
authors.forename: Antoine
authors.initials: A
authors.lastname: Dieudonné-Vatran
authors.forename: Michel
authors.initials: M
authors.lastname: Azoulay
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Florent