title: Effect of prostatitis on lower urinary tract symptoms: retrospective analysis of prostate biopsy tissue.
abstract: OBJECTIVE
  Most patients, even some urologists, assume that prostate volume is the most important prognostic factor for lower urinary tract symptoms (LUTS). In some cases, however, prostatic inflammation is a more important factor in LUTS than is prostate volume. For this reason, comparison of the impact on LUTS of inflammation and prostate volume is an attractive issue.
  
  
  METHODS
  From January 2000 to May 2009, 1,065 men aged between 47 and 91 years (who underwent transrectal ultrasound-guided prostate needle biopsy and transurethral prostatectomy) were retrospectively investigated. Components such as age, serum prostate-specific antigen (PSA) level, prostate volume, and the presence of prostatitis were investigated through independent-sample t-tests, chi-square tests, and univariate and multivariate analyses.
  
  
  RESULTS
  Chi-square tests between prostatitis, prostate volume, serum PSA, and severe LUTS showed that prostate volume (R=0.173; p=0.041) and prostatitis (R=0.148; p<0.001) were related to LUTS. In particular, for a prostate volume under 50 ml, prostatitis was a stronger risk factor than was prostate volume. Among the multivariate predictors, prostatitis (odds ratio [OR]: 1.945; p<0.001) and prostate volume (OR, 1.029; p<0.001) were found to be aggravating factors of LUTS.
  
  
  CONCLUSIONS
  For patients with prostate volume less than 50 ml, prostatitis was found to be a more vulnerable factor for LUTS. For those with prostate volume over 50 ml, on the other hand, the volume itself was a more significant risk factor than was prostatitis. In conclusion, the presence of prostatitis is one of the risk factors for LUTS with increased prostate volume.
authors.affiliation: Department of Urology, Inje University Sanggye Paik Hospital, Inje University College of Medicine, Seoul, Korea.
authors.forename: Jai Hyun
authors.initials: JH
authors.lastname: Chung
authors.forename: Ji Hyeong
authors.initials: JH
authors.lastname: Yu
authors.forename: Luck Hee
authors.initials: LH
authors.lastname: Sung
authors.forename: Chung Hee
authors.initials: CH
authors.lastname: Noh
authors.forename: Jae Yong
authors.initials: JY
authors.lastname: Chung