title: In vivo spreading of tau pathology.
abstract: Recent findings have suggested that tau pathology may spread in the brain by a prion-like mechanism. In this issue of Neuron, de Calignon et al. (2012) recreated an early stage of neurofibrillary tangle pathology to show that tau aggregates initially generated in a circumscribed area spread throughout the brain and lead to neurodegeneration.
authors.affiliation: Department of Neurology, Mitchell Center for Alzheimer's Disease and Related Brain Disorders, University of Texas Houston Medical School, Houston, TX 77030, USA. claudio.soto@uth.tmc.edu
authors.forename: Claudio
authors.initials: C
authors.lastname: Soto