title: Synthesis, spectral and solid state characterization of a new bioactive hydrazine bridged cyclic diphosphonium compound.
abstract: The facile preparation of a racemic hydrazine bridged diphosphonium compound possessing a ring system analogous to bicyclo[3.3.2]decane is reported. Although the reaction yield is low, the structure of the compound, which possesses an eight-membered ring, two phosphonium cationic centers, a biimino bridge, molecular chirality and two fused aromatic rings locked into roughly perpendicular planes is unusual. The compound displays substantial biological activity in the brine shrimp test and cleaves plasmid DNA.
authors.affiliation: Faculty of Chemistry, University of Belgrade, Studentski trg 12-16, 11000 Belgrade, Serbia.
authors.forename: Milica
authors.initials: M
authors.lastname: Milenković
authors.forename: Beata
authors.initials: B
authors.lastname: Warżajtis
authors.forename: Urszula
authors.initials: U
authors.lastname: Rychlewska
authors.forename: Dušanka
authors.initials: D
authors.lastname: Radanović
authors.forename: Katarina
authors.initials: K
authors.lastname: Anđelković
authors.forename: Tatjana
authors.initials: T
authors.lastname: Božić
authors.forename: Miroslava
authors.initials: M
authors.lastname: Vujčić
authors.forename: Dušan
authors.initials: D
authors.lastname: Sladić
mesh_terms: D000818:Animals; D001156:Artemia / Q000187:drug effects; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018360:Crystallography, X-Ray; D003603:Cytotoxins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D053837:DNA Cleavage; D004270:DNA, Circular / Q000737:chemistry; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D010957:Plasmids / Q000737:chemistry
chemical_list: C546486:10-R-9-borabicyclo(3.3.2)decane; D001643:Bridged Bicyclo Compounds; D003603:Cytotoxins; D004270:DNA, Circular