title: Mismatch negativity for speech sounds in temporal lobe epilepsy.
abstract: The mismatch negativity (MMN) is an electrophysiological trace of change detection, measured by electroencephalography (EEG), and is a reliable marker for pre-attentive auditory sensory memory. We used a phonetic oddball paradigm in patients with temporal lobe epilepsy (TLE) to elicit the MMN response at fronto-central sites and the mismatch positivity (MMP) response at mastoid sites. The MMN in 26 patients was compared with that of 26 age- and gender-matched healthy control participants. Electroencephalography responses were recorded during the presentation of speech sounds: the vowels 'a' and 'o' in alternation. Average waveforms were obtained for standard and deviant trials. We found that the MMP response at bilateral mastoid sites was reduced, whereas the MMN response at fronto-central sites did not change significantly. These results support the view that the MMN is generated by separable sources in the frontal and temporal lobes and that these sources are differentially affected by TLE.
authors.affiliation: Department of Life Sciences and Biofunctional Informatics, Graduate School of Health Care Sciences, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo, Japan. hrkeiko.bi@tmd.ac.jp
authors.forename: Keiko
authors.initials: K
authors.lastname: Hara
authors.forename: Katsuya
authors.initials: K
authors.lastname: Ohta
authors.forename: Miho
authors.initials: M
authors.lastname: Miyajima
authors.forename: Minoru
authors.initials: M
authors.lastname: Hara
authors.forename: Hiroko
authors.initials: H
authors.lastname: Iino
authors.forename: Ayasa
authors.initials: A
authors.lastname: Matsuda
authors.forename: Satsuki
authors.initials: S
authors.lastname: Watanabe
authors.forename: Eisuke
authors.initials: E
authors.lastname: Matsushima
authors.forename: Taketoshi
authors.initials: T
authors.lastname: Maehara
authors.forename: Masato
authors.initials: M
authors.lastname: Matsuura
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D000704:Analysis of Variance; D016022:Case-Control Studies; D003265:Contingent Negative Variation / Q000502:physiology*; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000503:physiopathology*; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010700:Phonetics; D011930:Reaction Time / Q000502:physiology; D013997:Time Factors; D055815:Young Adult