title: Cerebral microbleeds and age-related macular degeneration: the AGES-Reykjavik Study.
abstract: We test the hypothesis that cerebral microbleeds (CMB) and age-related macular degeneration (AMD), both linked to amyloid-β deposition, are correlated. This study includes 4205 participants (mean age 76.2; 57.8% women) in the Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study (2002-2006). CMB were assessed from magnetic resonance images, and AMD was assessed using digital retinal images. Data were analyzed with multinomial logistic models controlling for major confounders. Evidence of CMB was detected in 476 persons (272 with strict lobar CMB and 204 with nonlobar CMB). AMD was detected in 1098 persons (869 with early AMD, 140 with exudative AMD, and 89 with pure geographic atrophy). Early and exudative AMD were not associated with CMB. The adjusted odds ratio of pure geographic atrophy was 1.62 (95% confidence interval 0.93-2.82, p = 0.089) for having any CMB, 1.43 (0.66-3.06, p = 0.363) for strict lobar CMB, and 1.85 (0.89-3.87, p = 0.100) for nonlobar CMB. This study provides no evidence that amyloid deposits in the brain and AMD are correlated. However, the suggestive association of geographic atrophy with CMB warrants further investigation.
authors.affiliation: Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, USA. chengxuan.qiu@ki.se
authors.forename: Chengxuan
authors.initials: C
authors.lastname: Qiu
authors.forename: Mary Frances
authors.initials: MF
authors.lastname: Cotch
authors.forename: Sigurdur
authors.initials: S
authors.lastname: Sigurdsson
authors.forename: Gudny
authors.initials: G
authors.lastname: Eiriksdottir
authors.forename: Fridbert
authors.initials: F
authors.lastname: Jonasson
authors.forename: Ronald
authors.initials: R
authors.lastname: Klein
authors.forename: Barbara E K
authors.initials: BE
authors.lastname: Klein
authors.forename: Tamara B
authors.initials: TB
authors.lastname: Harris
authors.forename: Mark A
authors.initials: MA
authors.lastname: van Buchem
authors.forename: Vilmundur
authors.initials: V
authors.lastname: Gudnason
authors.forename: Lenore J
authors.initials: LJ
authors.lastname: Launer
mesh_terms: D000368:Aged; D016229:Amyloid beta-Peptides / Q000378:metabolism; D002543:Cerebral Hemorrhage / Q000453:epidemiology* / Q000473:pathology; D004777:Environment; D005260:Female; D057092:Geographic Atrophy / Q000453:epidemiology; D006801:Humans; D007055:Iceland / Q000453:epidemiology; D008268:Macular Degeneration / Q000453:epidemiology* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D012189:Retrospective Studies; D012307:Risk Factors; D013223:Statistics as Topic
chemical_list: D016229:Amyloid beta-Peptides