title: Synthesis and pharmacological characterization of potent, selective, and orally bioavailable isoindoline class dipeptidyl peptidase IV inhibitors.
abstract: Focused structure-activity relationships of isoindoline class DPP-IV inhibitors have led to the discovery of 4b as a highly selective, potent inhibitor of DPP-IV. In vivo studies in Wistar/ST rats showed that 4b was converted into the strongly active metabolite 4l in high yield, resulting in good in vivo efficacy for antihyperglycemic activity.
authors.affiliation: Central Research Laboratory, Sanwa Kagaku Kenkyusho, Co,, Ltd,, 363 Shiosaki, Hokusei-cho, Inabe-city, Mie 511-0406, Japan. n_katoh@mb4.skk-net.com.
authors.forename: Noriyasu
authors.initials: N
authors.lastname: Kato
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Oka
authors.forename: Takayo
authors.initials: T
authors.lastname: Murase
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yoshida
authors.forename: Masao
authors.initials: M
authors.lastname: Sakairi
authors.forename: Mirensha
authors.initials: M
authors.lastname: Yakufu
authors.forename: Satoko
authors.initials: S
authors.lastname: Yamashita
authors.forename: Yoshika
authors.initials: Y
authors.lastname: Yasuda
authors.forename: Aya
authors.initials: A
authors.lastname: Yoshikawa
authors.forename: Yuji
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Masahiro
authors.initials: M
authors.lastname: Shirai
authors.forename: Yukie
authors.initials: Y
authors.lastname: Mizuno
authors.forename: Mitsuaki
authors.initials: M
authors.lastname: Takeuchi
authors.forename: Mitsuhiro
authors.initials: M
authors.lastname: Makino
authors.forename: Motohiro
authors.initials: M
authors.lastname: Takeda
authors.forename: Takuji
authors.initials: T
authors.lastname: Kakigami