title: Iodine-catalyzed condensation of isatin with indoles: a facile synthesis of di(indolyl)indolin-2-ones and evaluation of their cytotoxicity.
abstract: Isatin reacts smoothly with indoles in the presence of a catalytic amount of molecular iodine under mild conditions to afford a novel class of di(indolyl)indolin-2-one derivatives in good yields. These molecules are found to possess a promising cytotoxicity against cancer cells only but not on normal cells.
authors.affiliation: Natural Product Chemistry, Indian Institute of Chemical Technology, Hyderabad 500 007, India. basireddy@iict.res.in
authors.forename: B V
authors.initials: BV
authors.lastname: Subba Reddy
authors.forename: N
authors.initials: N
authors.lastname: Rajeswari
authors.forename: M
authors.initials: M
authors.lastname: Sarangapani
authors.forename: Y
authors.initials: Y
authors.lastname: Prashanthi
authors.forename: Roopa Jones
authors.initials: RJ
authors.lastname: Ganji
authors.forename: Anthony
authors.initials: A
authors.lastname: Addlagatta
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002384:Catalysis; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D007211:Indoles / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D007455:Iodine / Q000737:chemistry*; D007510:Isatin / Q000737:chemistry*; D015394:Molecular Structure; D009928:Organ Specificity
chemical_list: D000970:Antineoplastic Agents; D007211:Indoles; D007510:Isatin; D007455:Iodine