title: Primary composite lymphoma of the larynx, composed of diffuse large B-cell lymphoma and peripheral T-cell lymphoma, not otherwise specified, presenting as left subglottic tracheal fistula, esophageal diverticulum, and neck abscess.
abstract: Primary laryngeal lymphoma occurs very rarely, accounting for far less than 1% of primary malignant laryngeal neoplasms. To the best of our knowledge, primary laryngeal composite lymphoma has not been reported in the literature. Herein, we report the first case of primary laryngeal composite lymphoma composed of diffuse large B-cell lymphoma (DLBCL) and peripheral T-cell lymphoma, not otherwise specified (PTCL, NOS), in a 43-year-old man. Of special interest is the patient's unique clinical presentation of left subglottic tracheal fistula, esophageal diverticulum, and neck abscess with no discrete mass identified. We describe the clinical and pathological characteristics of this case and review the literature.
authors.affiliation: Department of Pathology and Laboratory Medicine, The University of Kansas Medical Center, Kansas City, KS 66160, USA. wcui@kumc.edu
authors.forename: Wei
authors.initials: W
authors.lastname: Cui
authors.forename: Fang
authors.initials: F
authors.lastname: Fan
authors.forename: Da
authors.initials: D
authors.lastname: Zhang
authors.forename: Dave
authors.initials: D
authors.lastname: Garnett
authors.forename: Lowell
authors.initials: L
authors.lastname: Tilzer
mesh_terms: D000038:Abscess / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging; D000328:Adult; D058617:Composite Lymphoma / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D003937:Diagnosis, Differential; D004936:Diverticulum, Esophageal / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging; D017809:Fatal Outcome; D005931:Glottis / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D007822:Laryngeal Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D016411:Lymphoma, T-Cell, Peripheral / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D009333:Neck / Q000000981:diagnostic imaging / Q000473:pathology; D016156:Respiratory Tract Fistula / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging; D013194:Staining and Labeling; D014057:Tomography, X-Ray Computed; D014132:Trachea / Q000000981:diagnostic imaging / Q000473:pathology