title: Work-related asthma in France: recent trends for the period 2001-2009.
abstract: OBJECTIVE
  Knowledge on the time-course (trends) of work-related asthma (WRA) remains sparse. The aim of this study was to describe WRA trends in terms of industrial activities and the main causal agents in France over the period 2001-2009.
  
  
  METHODS
  Data were collected from the French national network of occupational health surveillance and prevention (Réseau National de Vigilance et de Prévention des Pathologies Professionnelles (RNV3P)). Several statistical models (non-parametric test, zero-inflated negative binomial, logistic regression and time-series models) were used and compared with assess trends.
  
  
  RESULTS
  Over the study period, 2914 WRA cases were included in the network. A significant decrease was observed overall and for some agents such as isocyanates (p = 0.007), aldehydes (p = 0.01) and latex (p = 0.01). Conversely, a significant increase was observed for cases related to exposure to quaternary ammonium compounds (p = 0.003). The health and social sector demonstrated both a growing number of cases related to the use of quaternary ammonium compounds and a decrease of cases related to aldehyde and latex exposure.
  
  
  CONCLUSIONS
  WRA declined in France over the study period. The only significant increase concerned WRA related to exposure to quaternary ammonium compounds. Zero-inflated negative binomial and logistic regression models appear to describe adequately these data.
authors.affiliation: Inserm Research Unit U954, 9 rue de la Foret de Haye, Vandoeuvre Les Nancy 54505, France. christophe.paris@nancy.inserm.fr
authors.forename: Christophe
authors.initials: C
authors.lastname: Paris
authors.forename: Joseph
authors.initials: J
authors.lastname: Ngatchou-Wandji
authors.forename: Amandine
authors.initials: A
authors.lastname: Luc
authors.forename: Roseanne
authors.initials: R
authors.lastname: McNamee
authors.forename: Lynda
authors.initials: L
authors.lastname: Bensefa-Colas
authors.forename: Lynda
authors.initials: L
authors.lastname: Larabi
authors.forename: Maylis
authors.initials: M
authors.lastname: Telle-Lamberton
authors.forename: Fabrice
authors.initials: F
authors.lastname: Herin
authors.forename: Alain
authors.initials: A
authors.lastname: Bergeret
authors.forename: Vincent
authors.initials: V
authors.lastname: Bonneterre
authors.forename: Patrick
authors.initials: P
authors.lastname: Brochard
authors.forename: Dominique
authors.initials: D
authors.lastname: Choudat
authors.forename: Dominique
authors.initials: D
authors.lastname: Dupas
authors.forename: Robert
authors.initials: R
authors.lastname: Garnier
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Pairon
authors.forename: Raymond M
authors.initials: RM
authors.lastname: Agius
authors.forename: Jacques
authors.initials: J
authors.lastname: Ameille
mesh_terms: D000328:Adult; D000395:Air Pollutants, Occupational / Q000009:adverse effects*; D059366:Asthma, Occupational / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D005602:France / Q000453:epidemiology; D006306:Health Surveys; D006801:Humans; D015994:Incidence; D007221:Industry; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects* / Q000706:statistics & numerical data; D016017:Odds Ratio; D011159:Population Surveillance
chemical_list: D000395:Air Pollutants, Occupational