title: [Helicobacter pylori and gastroduodenal lesions in Dakar, Senegal].
abstract: BACKGROUND
  The bacteriological characteristics of Helicobacter pylori (HP) vary in function of time and place. The aim of this study was to update histological and bacteriological feature of HP infection in patients presenting gastroduodenal lesions in Dakar, Senegal.
  
  
  METHODS
  This prospective study included patients with gastroduodenal lesions managed over a 6-month period in a digestive endoscopy center in Dakar. In all cases gastric biopsy was performed to obtain specimens for histological diagnosis according Sydney modified classification and HP culture with antibiogram.
  
  
  RESULTS
  A total of 158 patients were included. Mean patient age was 48.7 years and the sex-ratio was 1.2. Endoscopic lesions were ulcer in 88 cases, gastritis in 54 cases and tumors in 16. Histological examination demonstrated chronic gastritis in 100% of cases, inflammatory activity in 79.1%, metaplasia in 78.5%, gastric atrophy in 41.1%, adenocarcinoma in 7.6%, dysplasia in 5.7%, and MALT lymphoma in 2.5% with presence of HP in 72.8% of cases. Cultures were positive for HP in 65.8% of cases. Antibiograms indicated that HP was sensitive to amoxicilline in 100% of cases, clarithromycine in 96.6%, ciprofloxacine in 84.1%, and métronidazole in 29.5%.
  
  
  CONCLUSIONS
  Chronic gastritis is a constant feature of gastroduodenal lesions in Dakar. Histology combined with culture showed HP infection in 78.5% of cases. The antibiotic sensitivity of HP in Dakar has changed over the past decade.
authors.affiliation: Service d'hépato-gastroentérologie, CHU Aristide Le Dantec, Dakar, Sénégal. daoudadia17@yahoo.fr
authors.forename: D
authors.initials: D
authors.lastname: Dia
authors.forename: A
authors.initials: A
authors.lastname: Seck
authors.forename: M
authors.initials: M
authors.lastname: Mbengue
authors.forename: M L
authors.initials: ML
authors.lastname: Bassène
authors.forename: S
authors.initials: S
authors.lastname: Breurec
authors.forename: B
authors.initials: B
authors.lastname: Fall
authors.forename: C
authors.initials: C
authors.lastname: Fall
authors.forename: M L
authors.initials: ML
authors.lastname: Diouf
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002648:Child; D002908:Chronic Disease; D005260:Female; D005767:Gastrointestinal Diseases / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D016481:Helicobacter Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012675:Senegal / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents