title: Cyto-morphologic evaluation of bone marrow in infants with disseminated neuroblastoma.
abstract: We studied the prevalence and degree of tumor cell infiltration (TCI) in bone marrow (BM) aspirates of 89 infants with stage 4/4 S neuroblastoma and correlated them with MYCN gene status and patient outcome. TCI was scored 0, +, ++, and +++, the last corresponding to an infiltration greater than 10%. TCI 0 was more frequent in stage 4 than in stage 4 S. TCI + and ++ were equally represented. TCI +++ was found only in 9 patients, all with typical stage 4 features (bone or lung involvement). Overall survival was not significantly influenced by the presence and degree of TCI.
authors.affiliation: Department of Haematology-Oncology, Giannina Gaslini Children's Hospital, National Cancer Research Institute, Genova, Italy. sorryste@gmail.com
authors.forename: Stefania
authors.initials: S
authors.lastname: Sorrentino
authors.forename: Cristina
authors.initials: C
authors.lastname: Rosanda
authors.forename: Stefano
authors.initials: S
authors.lastname: Parodi
authors.forename: Anna
authors.initials: A
authors.lastname: Rita Gigliotti
authors.forename: Mirella
authors.initials: M
authors.lastname: Pasino
authors.forename: Raffaella
authors.initials: R
authors.lastname: Defferrari
authors.forename: Gian Paolo
authors.initials: GP
authors.lastname: Tonini
authors.forename: Bruno
authors.initials: B
authors.lastname: De Bernardi
mesh_terms: D001853:Bone Marrow / Q000473:pathology*; D019046:Bone Marrow Neoplasms / Q000473:pathology; D005260:Female; D006801:Humans; D007223:Infant; D053208:Kaplan-Meier Estimate; D008297:Male; D000071447:N-Myc Proto-Oncogene Protein; D009367:Neoplasm Staging; D009447:Neuroblastoma / Q000235:genetics / Q000401:mortality / Q000556:secondary*; D009687:Nuclear Proteins / Q000235:genetics; D015513:Oncogene Proteins / Q000235:genetics
chemical_list: C459801:MYCN protein, human; D000071447:N-Myc Proto-Oncogene Protein; D009687:Nuclear Proteins; D015513:Oncogene Proteins