title: EF hand-mediated Ca- and cGMP-signaling in photoreceptor synaptic terminals.
abstract: Photoreceptors, the light-sensitive receptor neurons of the retina, receive and transmit a plethora of visual informations from the surrounding world. Photoreceptors capture light and convert this energy into electrical signals that are conveyed to the inner retina. For synaptic communication with the inner retina, photoreceptors make large active zones that are marked by synaptic ribbons. These unique synapses support continuous vesicle exocytosis that is modulated by light-induced, graded changes of membrane potential. Synaptic transmission can be adjusted in an activity-dependent manner, and at the synaptic ribbons, Ca(2+)- and cGMP-dependent processes appear to play a central role. EF-hand-containing proteins mediate many of these Ca(2+)- and cGMP-dependent functions. Since continuous signaling of photoreceptors appears to be prone to malfunction, disturbances of Ca(2+)- and cGMP-mediated signaling in photoreceptors can lead to visual defects, retinal degeneration (rd), and even blindness. This review summarizes aspects of signal transmission at the photoreceptor presynaptic terminals that involve EF-hand-containing Ca(2+)-binding proteins.
authors.affiliation: Department of Neuroanatomy, Medical School Homburg/Saar, Institute for Anatomy and Cell Biology, Saarland University Saarland, Germany.
authors.forename: Frank
authors.initials: F
authors.lastname: Schmitz
authors.forename: Sivaraman
authors.initials: S
authors.lastname: Natarajan
authors.forename: Jagadeesh K
authors.initials: JK
authors.lastname: Venkatesan
authors.forename: Silke
authors.initials: S
authors.lastname: Wahl
authors.forename: Karin
authors.initials: K
authors.lastname: Schwarz
authors.forename: Chad P
authors.initials: CP
authors.lastname: Grabner