title: Design, synthesis and antihypertensive screening of novel pyridazine substituted s-triazin-2-imine/one/thione derivatives.
abstract: Some new 7-substituted-phenyl-3,4,8,9-tetrahydro-2H-pyridazino[1,6-a][1,3,5]triazin-2-imine/one/thione derivatives were synthesized by a sequence of reactions starting from appropriate aryl hydrocarbons. The final compounds were screened for antihypertensive activities by non-invasive method using Tail Cuff method. All the test compounds showed significant antihypertensive activity; 7-(biphenyl-4-yl)-3,4,8,9-tetrahydro-2H-pyridazino[1,6-a][1,3,5]triazin-2-imine (4p) exhibited antihypertensive activity more than the reference standard drugs.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), Hamdard Nagar, New Delhi, (India). ravi_kcp@rediffmail.com
authors.forename: Ravinesh
authors.initials: R
authors.lastname: Mishra
authors.forename: Anees A
authors.initials: AA
authors.lastname: Siddiqui
authors.forename: Asif
authors.initials: A
authors.lastname: Husain
authors.forename: Mohd
authors.initials: M
authors.lastname: Rashid
authors.forename: Chirag
authors.initials: C
authors.lastname: Goda
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D060326:Chemistry Techniques, Synthetic; D015195:Drug Design; D004353:Drug Evaluation, Preclinical / Q000379:methods; D007097:Imines / Q000737:chemistry; D011724:Pyridazines / Q000737:chemistry* / Q000494:pharmacology; D051381:Rats; D013871:Thiones / Q000737:chemistry; D014227:Triazines / Q000737:chemistry / Q000494:pharmacology
chemical_list: C583375:7-(biphenyl-4-yl)-3,4,8,9-tetrahydro-2H-pyridazino(1,6-a)(1,3,5)triazin-2-imine; D000959:Antihypertensive Agents; D007097:Imines; D011724:Pyridazines; D013871:Thiones; D014227:Triazines; C062482:pyridazine