title: A selective intramolecular transacylation of taxoids accompanying with the oxetane ring opening.
abstract: A selective intramolecular transacylation from C-4 to C-5 of taxoids, which occurred simultaneously with the oxetane D-ring opening and was promoted by TiCl4, was presented. The optimal condition was found to be treatment of substrates in double dose of dichloromethane (per mg of substrate dissolved in 2 mL DCM) with 1 eq of TiCl4 at 25°C for 10 min.
authors.affiliation: Department of Chinese Traditional Herbal, Agronomy College, Sichuan Agricultural University, Chengdu, PR China. gaofeng@sicau.edu.cn
authors.forename: Feng
authors.initials: F
authors.lastname: Gao
authors.forename: Min
authors.initials: M
authors.lastname: Yu
authors.forename: Qiao-Hong
authors.initials: QH
authors.lastname: Chen
authors.forename: Feng-Peng
authors.initials: FP
authors.lastname: Wang
mesh_terms: D000215:Acylation; D004988:Ethers, Cyclic / Q000737:chemistry*; D008752:Methylene Chloride / Q000737:chemistry*; D043823:Taxoids / Q000737:chemistry*; D014025:Titanium / Q000737:chemistry*
chemical_list: D004988:Ethers, Cyclic; D043823:Taxoids; D008752:Methylene Chloride; C025096:titanium tetrachloride; D014025:Titanium; C005287:oxetane