title: Low serum mannose-binding lectin level is not associated with disease severity in non-cystic fibrosis bronchiectasis.
abstract: Deficiency of mannose-binding lectin (MBL), a serum protein involved in killing and promoting phagocytosis of pathogens, is associated with respiratory infection and disease progression in a number of acute and chronic lung diseases, including cystic fibrosis (CF)- associated bronchiectasis. No such association has been studied in non-CF bronchiectasis (nCF-Br). One hundred and thirty-three adult patients with nCF-Br were studied. Serum MBL levels were measured and deficiency defined using two cut-off levels, i.e. MBL ≤100 ng/ml and ≤600 ng/ml. Parameters of severity included lung function impairment, annual exacerbation and hospital admission rates, breathlessness, and Pseudomonas aeruginosa and Haemophilus influenzae infection rates. The incidence of MBL deficiency using cut-off levels of 100 ng/ml and 600 ng/ml was 10% and 26% respectively, similar to rates seen in the general population. There was no significant difference in mean FEV(1)% predicted between MBL deficient and sufficient patients at both cut-off levels (≤100 ng/ml: 63.8% vs. 64.6%, P = 0.91; ≤ 600 ng/ml: 66.5% vs. 63.9%, P = 0.56). In addition, exacerbation/hospital admission rates, symptoms of breathlessness and isolation/colonisation rates with P. aeruginosa and H. influenzae were similar in both groups at both cut-off levels. In conclusion, MBL deficiency is not associated with markers of disease severity in patients with nCF-Br.
authors.affiliation: Institute of Cellular Medicine, Newcastle University, Newcastle-upon-Tyne, UK. james.macfarlane2@ncl.ac.uk
authors.forename: James G
authors.initials: JG
authors.lastname: Macfarlane
authors.forename: Hannah
authors.initials: H
authors.lastname: Jary
authors.forename: Katharine L M
authors.initials: KL
authors.lastname: Hester
authors.forename: Paul
authors.initials: P
authors.lastname: McAlinden
authors.forename: Jonathan
authors.initials: J
authors.lastname: Wake
authors.forename: Therese
authors.initials: T
authors.lastname: Small
authors.forename: Kathy E
authors.initials: KE
authors.lastname: Walton
authors.forename: Gavin
authors.initials: G
authors.lastname: Spickett
authors.forename: Anthony
authors.initials: A
authors.lastname: De Soyza
mesh_terms: D000328:Adult; D001987:Bronchiectasis / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D003550:Cystic Fibrosis / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D018450:Disease Progression; D006192:Haemophilus Infections / Q000453:epidemiology; D006193:Haemophilus influenzae / Q000302:isolation & purification; D006760:Hospitalization; D006801:Humans; D008168:Lung / Q000378:metabolism* / Q000473:pathology; D037601:Mannose-Binding Lectin / Q000097:blood* / Q000172:deficiency; D011379:Prognosis; D011552:Pseudomonas Infections / Q000453:epidemiology; D011550:Pseudomonas aeruginosa / Q000302:isolation & purification; D012129:Respiratory Function Tests; D012141:Respiratory Tract Infections / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D012189:Retrospective Studies
chemical_list: D037601:Mannose-Binding Lectin