title: The cell biology of regeneration.
abstract: Regeneration of complex structures after injury requires dramatic changes in cellular behavior. Regenerating tissues initiate a program that includes diverse processes such as wound healing, cell death, dedifferentiation, and stem (or progenitor) cell proliferation; furthermore, newly regenerated tissues must integrate polarity and positional identity cues with preexisting body structures. Gene knockdown approaches and transgenesis-based lineage and functional analyses have been instrumental in deciphering various aspects of regenerative processes in diverse animal models for studying regeneration.
authors.affiliation: Howard Hughes Medical Institute, Department of Cell and Developmental Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.
authors.forename: Ryan S
authors.initials: RS
authors.lastname: King
authors.forename: Phillip A
authors.initials: PA
authors.lastname: Newmark
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology; D003585:Cell Biology; D054337:Cell Dedifferentiation; D049109:Cell Proliferation; D006801:Humans; D012038:Regeneration / Q000502:physiology*; D044968:Regenerative Medicine