title: Total lymphocyte count is a reliable surrogate marker for CD4 cell counts after the first year of antiretroviral therapy: data from an Indonesian cohort study.
abstract: Many studies have evaluated the total lymphocyte count (TLC) as a cheap surrogate marker for CD4 cells in HIV-infected patients not receiving antiretroviral therapy (ART). We assessed whether TLC can replace CD4 cell counts in evaluating the immunological response to ART. In a cohort of patients in Indonesia TLC, if measured after at least 1-year ART, correctly identified patients with <200 CD4 cells, and reliably excluded immunological failure, obviating the need for CD4 cell measurement in 43% of patients.
authors.affiliation: Department of Internal Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
authors.forename: Marrigje A
authors.initials: MA
authors.lastname: de Jong
authors.forename: Rudi
authors.initials: R
authors.lastname: Wisaksana
authors.forename: Hinta
authors.initials: H
authors.lastname: Meijerink
authors.forename: Agnes
authors.initials: A
authors.lastname: Indrati
authors.forename: Andre J A M
authors.initials: AJ
authors.lastname: van de Ven
authors.forename: Bachti
authors.initials: B
authors.lastname: Alisjahbana
authors.forename: Reinout
authors.initials: R
authors.lastname: van Crevel
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000097:blood / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods / Q000706:statistics & numerical data*; D015415:Biomarkers / Q000097:blood; D018791:CD4 Lymphocyte Count / Q000379:methods / Q000706:statistics & numerical data*; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D015658:HIV Infections / Q000097:blood* / Q000188:drug therapy*; D006801:Humans; D007214:Indonesia; D018655:Lymphocyte Count / Q000379:methods / Q000706:statistics & numerical data*; D008297:Male; D011446:Prospective Studies; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D017678:Sex Distribution; D016896:Treatment Outcome
chemical_list: D019380:Anti-HIV Agents; D015415:Biomarkers