title: Sea-originated cytotoxic substances.
abstract: Cancer accounted for huge number of deaths, which represents about 13% of all deaths worldwide, and the number of the deaths due to cancer is increasing. Natural products and their synthetic analogs are widely used as antitumor drugs. As represented by these drugs, many anticancer drugs originated from cytotoxic compounds. Marine natural products are a gold mine of strong bioactive compounds with unique structures created in evolution of organisms over hundred million years. However, in the field of drug discovery, most studies have focused on plant essences and bacterial metabolites, and candidate compounds from marine origin are still remaining relatively unexplored.
authors.affiliation: Department of Chemistry, Faculty of Science, Kanagawa University, Hiratsuka, Japan.
authors.forename: Norihito
authors.initials: N
authors.lastname: Maru
authors.forename: Daisuke
authors.initials: D
authors.lastname: Uemura
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000378:metabolism; D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology / Q000627:therapeutic use; D059001:Aquatic Organisms / Q000378:metabolism*; D000458:Cyanobacteria / Q000378:metabolism; D003521:Cyclopropanes / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D055808:Drug Discovery; D006801:Humans; D018942:Macrolides / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D008387:Marine Toxins / Q000096:biosynthesis* / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D010456:Peptides, Cyclic / Q000096:biosynthesis / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D011161:Porifera / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D003521:Cyclopropanes; D018942:Macrolides; D008387:Marine Toxins; D010456:Peptides, Cyclic