title: Cancer deaths and occupational exposure in a group of plutonium workers.
abstract: An exploratory epidemiological study was conducted for 319 deceased nuclear workers who had intakes of transuranic radionuclides and histories of employment during the time period from 1943 to 1995. The workers were employed at various facilities throughout the United States, including the Department of Energy defense facilities and uranium mining and milling sites. The majority of individuals were involved in documented radiological incidents during their careers. All had voluntarily agreed to donate their organs or whole body to the United States Transuranium and Uranium Registries. External and internal dose assessments were performed using occupational exposure histories and postmortem concentrations of transuranic radionuclides in critical organs. Statistical data analyses were performed to investigate the potential relationship between radiation exposure and causes of death within this population due to cancers of the lungs, liver, and all sites combined while controlling for the effects of other confounders. No association was found between radiation exposure and death due to cancer (α = 0.05). However, statistically significant associations were found between death due to any type of cancer and smoking (yes or no) (odds ratio = 5.41; 95% CI: 1.42 to 20.67) and rate of cigarette smoking (packs per day) (odds ratio = 2.70; 95% CI: 1.37 to 5.30).
authors.affiliation: Bloomsburg University, Department of Physics and Engineering Technology, 400 East 2nd Street, Bloomsburg, PA 17815-1301, USA. nfallahi@bloomu.edu
authors.forename: Naz Afarin
authors.initials: NA
authors.lastname: Fallahian
authors.forename: Richard R
authors.initials: RR
authors.lastname: Brey
authors.forename: Rick D
authors.initials: RD
authors.lastname: Tivis
authors.forename: Neill F
authors.initials: NF
authors.lastname: Piland
authors.forename: David R
authors.initials: DR
authors.lastname: Simpson
mesh_terms: D004307:Dose-Response Relationship, Radiation; D006801:Humans; D016013:Likelihood Functions; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000209:etiology* / Q000401:mortality*; D016273:Occupational Exposure / Q000009:adverse effects*; D011005:Plutonium / Q000009:adverse effects*; D013997:Time Factors
chemical_list: D011005:Plutonium