title: Co-trimoxazole-induced myopia in an HIV-positive patient.
abstract: Co-trimoxazole is a commonly used drug in the treatment and prophylaxis of opportunistic infections in HIV seropositive patients. We report a case of a 35-year-old HIV-infected man who presented with blurring of vision one week following initiation of co-trimoxazole therapy. A diagnosis of co-trimoxazole-induced myopia, a known idiosyncratic drug reaction, was made. The drug was withheld and the myopia resolved completely. Although in this patient the ocular condition resolved completely, serious ocular adverse reactions have also been reported with co-trimoxazole. This case report highlights the occurrence of ocular adverse drug reactions (ADRs) in HIV-infected patients on co-trimoxazole and the complexity of drug interactions.
authors.affiliation: Department of Ophthalmology, St John's Medical College, Bangalore, India. kamathsripathi@gmail.com
authors.forename: S
authors.initials: S
authors.lastname: Kamath
authors.forename: N
authors.initials: N
authors.lastname: Acharya
authors.forename: S
authors.initials: S
authors.lastname: Nithyanandam
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000517:prevention & control; D000328:Adult; D000890:Anti-Infective Agents / Q000009:adverse effects* / Q000627:therapeutic use; D006679:HIV Seropositivity / Q000188:drug therapy*; D006801:Humans; D008297:Male; D009216:Myopia / Q000139:chemically induced*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000890:Anti-Infective Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination