title: Laser ablation in titanium implants followed by biomimetic hydroxyapatite coating: Histomorphometric study in rabbits.
abstract: Titanium surface texture and chemistry modification successfully improves the host response and consequently the bone-to-implant contact surrounding dental implants. The aim of the present study was to investigate, using histomorphometrical-analysis, the effects of titanium surface modification by laser-ablation (Nd:YAG) followed by thin chemical deposition of HA. Forty-eight rabbits received one implant by tibiae of AS-machined (MS), laser-modified (LMS), or biomimetic hydroxyapatite-coated (HA) surface. Bone-to-implant contact (BIC) and bone area (BBT) were evaluated after 4, 8, and 12 weeks, at cortical and cancellous regions. Average BIC in the cortical region was higher (P < 0.001) on the LMS and HA implants for all periods, with no differences between LMS and HA. For the cancellous area, the LMS and HA implants showed higher (P < 0.01) BIC than MS at the initial periods. The LMS and HA showed similar values in the cortical region, but a tendency of higher values for HA in the cancellous region was observed in all periods. For the BBT, the differences were found only between HA and MS after 4 weeks in the cortical region (P < 0.05), and after 12 weeks in the cancellous area (P < 0.05). Our results showed that HA biomimetic coating preceded by laser treatment induced the contact osteogenesis and allowed the formation of a more stable bone-implant interface, even in earlier periods.
authors.affiliation: Department of Post-Graduation in Implantology, UNIARA-Araraquara University, Araraquara, São Paulo, Brazil. rafaelfaeda@gmail.com
authors.forename: Rafael Silveira
authors.initials: RS
authors.lastname: Faeda
authors.forename: Rubens
authors.initials: R
authors.lastname: Spin-Neto
authors.forename: Elcio
authors.initials: E
authors.lastname: Marcantonio
authors.forename: Antonio Carlos
authors.initials: AC
authors.lastname: Guastaldi
authors.forename: Elcio
authors.initials: E
authors.lastname: Marcantonio
mesh_terms: D000818:Animals; D020099:Coated Materials, Biocompatible / Q000627:therapeutic use*; D017886:Durapatite / Q000627:therapeutic use*; D006651:Histocytochemistry; D053685:Laser Therapy; D008855:Microscopy, Electron, Scanning; D023421:Models, Animal; D010012:Osteogenesis; D019736:Prostheses and Implants; D011817:Rabbits; D013977:Tibia / Q000502:physiology / Q000601:surgery; D014025:Titanium / Q000009:adverse effects*
chemical_list: D020099:Coated Materials, Biocompatible; D017886:Durapatite; D014025:Titanium