title: Bilateral non-contiguous atypical papillary glioneuronal tumor: case report.
abstract: Papillary glioneuronal tumor (PGNT) was first described as a distinct clinic-pathological entity by Komori et al. in 1998. Since then it has been included as a mixed neuronal-glial tumor in the revised WHO (2007) classification of central nervous system tumors. On brain imaging, it appears as a demarcated, solid to cystic, contrast-enhancing mass usually located in the temporal lobe. Histologically, it is considered a biphasic tumor characterized by small cuboidal GFAP-positive astrocytes around hyalinised blood vessels and synaptophysin-positive interpapillary collections of neurocytes, large neurons and intermediate-sized "ganglioid cells". Although they are generally regarded as benign WHO Grade I tumors, recent reports have described more pathologically aggressive features. To date, these reports have all been single lesions.
authors.affiliation: Department of Neurosurgery, University of Edinburgh, Edinburgh, UK. t.flannery@qub.ac.uk
authors.forename: Thomas
authors.initials: T
authors.lastname: Flannery
authors.forename: Andrew
authors.initials: A
authors.lastname: Purce
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Harney
authors.forename: Steven
authors.initials: S
authors.lastname: McKinstry
authors.forename: James W
authors.initials: JW
authors.lastname: Ironside
authors.forename: Brian
authors.initials: B
authors.lastname: Herron
mesh_terms: D001253:Astrocytes / Q000378:metabolism / Q000473:pathology*; D001932:Brain Neoplasms / Q000378:metabolism / Q000473:pathology*; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D005910:Glioma / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D009474:Neurons / Q000378:metabolism / Q000473:pathology*; D013702:Temporal Lobe / Q000378:metabolism / Q000473:pathology*
chemical_list: D005904:Glial Fibrillary Acidic Protein