title: [Biological function of bone cells on the PTH-driven anabolic effect].
abstract: Parathyroid hormone (PTH) -driven anabolism in bone appears to involve the osteoblastic activation and the increased population of preosteoblastic lineages. Given that the activities of osteoclasts and osteoblasts are intertwined during normal bone remodeling, it is plausible that the anabolic action of PTH is either directly or indirectly related to the osteoclast. We have recently reported that the absence of osteoclasts in c-fos( - / - ) mice might hinder PTH-driven bone anabolism, and that osteoclastic presence may be necessary for full osteoblastic differentiation and enhanced bone formation seen after intermittent PTH administration. Alternatively, it was suggested that PTH administration inhibits sclerostin synthesis by osteocytes, thereby allowing for active bone formation. Taken together, PTH affects bone cells in a dual pathway - mediating osteoblastic (preosteoblastic) activities or osteocytic synthesis of sclerostin -.
authors.affiliation: Department of Developmental Biology of Hard Tissue, Hokkaido University, Japan.
authors.forename: Tomoka
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Hiromi
authors.initials: H
authors.lastname: Hongo
authors.forename: Muneteru
authors.initials: M
authors.lastname: Sasaki
authors.forename: Tamaki
authors.initials: T
authors.lastname: Yamada
authors.forename: Norio
authors.initials: N
authors.lastname: Amizuka
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000096:biosynthesis; D016723:Bone Remodeling; D001842:Bone and Bones / Q000378:metabolism*; D002454:Cell Differentiation; D005819:Genetic Markers; D006801:Humans; D051379:Mice; D010006:Osteoblasts / Q000166:cytology*; D010010:Osteoclasts / Q000502:physiology; D010011:Osteocytes / Q000378:metabolism; D010012:Osteogenesis / Q000187:drug effects*; D010281:Parathyroid Hormone / Q000008:administration & dosage* / Q000494:pharmacology* / Q000502:physiology
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D019485:Bone Morphogenetic Proteins; D005819:Genetic Markers; D010281:Parathyroid Hormone; C422903:SOST protein, human