title: Decreased plasma gelsolin is associated with 1-year outcome in patients with traumatic brain injury.
abstract: OBJECTIVE
  Decreased plasma gelsolin level has been associated with 1-month mortality after traumatic brain injury (TBI). Thus, we investigated the ability of gelsolin to predict 1-year mortality and functional outcome in these patients.
  
  
  METHODS
  One hundred fourteen healthy controls and 114 patients with acute severe TBI were included in this study. Plasma gelsolin concentration on admission was measured by ELISA.
  
  
  RESULTS
  Fifty-five patients (48.2%) had unfavorable outcome (Glasgow Outcome Scale score of 1-3) and 38 patients (33.3%) died in 1 year after TBI. Upon admission, plasma gelsolin level in patients was substantially lower than that in healthy controls. A multivariate analysis selected plasma gelsolin level as an independent predictor for 1-year unfavorable outcome and mortality of patients. A receiver operating characteristic curve analysis showed plasma gelsolin level predicted 1-year unfavorable outcome and mortality statistically significantly. The predictive value of the gelsolin concentration was thus similar to that of Glasgow Coma Scale (GCS) score. In a combined logistic-regression model, gelsolin did not statistically significantly improve the area under curve of GCS score.
  
  
  CONCLUSIONS
  Plasma gelsolin level is a useful, complementary tool to predict functional outcome and mortality 1 year after TBI.
authors.affiliation: Department of Neurosurgery, Affiliated Taizhou Municipal Hospital, Taizhou University, Jiaojiang District, Taizhou 318000, China. taizhoujinyong@163.com
authors.forename: Yong
authors.initials: Y
authors.lastname: Jin
authors.forename: Bo-You
authors.initials: BY
authors.lastname: Li
authors.forename: Ling-Li
authors.initials: LL
authors.lastname: Qiu
authors.forename: Yuan-Ren
authors.initials: YR
authors.lastname: Ling
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Bai
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D015415:Biomarkers; D001930:Brain Injuries / Q000097:blood* / Q000175:diagnosis / Q000401:mortality*; D005260:Female; D018260:Gelsolin / Q000097:blood*; D023261:Glasgow Outcome Scale; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012680:Sensitivity and Specificity; D012737:Sex Factors
chemical_list: D015415:Biomarkers; D018260:Gelsolin