title: Triterpene saponins from Antonia ovata leaves.
abstract: Six pentacyclic triterpenoid saponins, named antoniosides E-J along with two known alkaloids, were isolated from the leaves of Antonia ovata. Their structures were determined by the extensive use of 1D and 2D-NMR experiments along with HRESIMS analysis and acid hydrolysis. All isolated saponins contained the same pentasaccharide chain: 3-O-[β-D-glucopyranosyl-(1→2)]-[β-D-glucopyranosyl-(1→4)]-[β-D-glucopyranosyl-(1→3)-α-L-arabinopyranosyl(1→6)]-β-D-glucopyranoside, linked at C-3 of esterified derivatives of polyhydroxyoleanene triterpenoids (theasapogenol A and 15α-hydroxy-theasapogenol A). Isolated compounds were evaluated for their cytotoxic activity against KB cell line by a WST-1 assay, and the IC(50) values ranged from 3.3 to 5.3 μM.
authors.affiliation: Laboratoire de Pharmacognosie, Institut de Chimie Moléculaire de Reims, UMR CNRS 6229, IFR 53 Biomolécules, Bâtiment 18, BP 1039, 51687 Reims cedex 2, France. abdulmagid.alabdulmagid@univ-reims.fr
authors.forename: Abdulmagid
authors.initials: A
authors.lastname: Alabdul Magid
authors.forename: Nathalie
authors.initials: N
authors.lastname: Lalun
authors.forename: Christophe
authors.initials: C
authors.lastname: Long
authors.forename: Nicolas
authors.initials: N
authors.lastname: Borie
authors.forename: Hélène
authors.initials: H
authors.lastname: Bobichon
authors.forename: Christian
authors.initials: C
authors.lastname: Moretti
authors.forename: Catherine
authors.initials: C
authors.lastname: Lavaud
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D007624:KB Cells; D029541:Loganiaceae / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; D014315:Triterpenes