title: Effect of coronary bypass and valve structure on outcome in isolated valve replacement for aortic stenosis.
abstract: Reports differ regarding the effect of concomitant coronary artery bypass grafting (CABG) in patients who undergo aortic valve replacement (AVR) for aortic stenosis (AS), and no reports have described the effect of aortic valve structure in patients who undergo AVR for AS. A total of 871 patients aged 24 to 94 years (mean 70) whose AVR for AS was their first cardiac operation, with or without first concomitant CABG, were included. Patients who underwent mitral valve procedures were excluded. In comparison with the 443 patients (51%) who did not undergo CABG, the 428 (49%) who underwent concomitant CABG were significantly older, were more often male, had lower transvalvular peak systolic pressure gradients and larger valve areas, had lower frequencies of congenitally malformed aortic valves, had lighter valves by weight, had higher frequencies of systemic hypertension, and had longer stays in the hospital after AVR. Early and late (to 10 years) mortality were similar by propensity-adjusted analysis in patients who did and did not undergo concomitant CABG. Congenitally unicuspid or bicuspid valves occurred in approximately 90% of those aged 21 to 50, in nearly 70% in those aged 51 to 70 years, and in just over 30% in those aged 71 to 95 years. Unadjusted and adjusted survival was significantly higher in patients with unicuspid or bicuspid valves compared to those with tricuspid valves. In conclusion, although concomitant CABG had no effect on the adjusted probability of survival, the type of aortic valve (unicuspid or bicuspid vs tricuspid) significantly affected the unadjusted and adjusted probability of survival.
authors.affiliation: Department of Internal Medicine, Division of Cardiology, Baylor University Medical Center, Dallas, Texas, USA. wc.roberts@baylorhealth.edu
authors.forename: William Clifford
authors.initials: WC
authors.lastname: Roberts
authors.forename: Carey Camille
authors.initials: CC
authors.lastname: Roberts
authors.forename: Travis James
authors.initials: TJ
authors.lastname: Vowels
authors.forename: Jong Mi
authors.initials: JM
authors.lastname: Ko
authors.forename: Giovanni
authors.initials: G
authors.lastname: Filardo
authors.forename: Baron Lloyd
authors.initials: BL
authors.lastname: Hamman
authors.forename: Gregory John
authors.initials: GJ
authors.lastname: Matter
authors.forename: Albert Carl
authors.initials: AC
authors.lastname: Henry
authors.forename: Robert Frederick
authors.initials: RF
authors.lastname: Hebeler
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001021:Aortic Valve / Q000473:pathology* / Q000601:surgery; D001024:Aortic Valve Stenosis / Q000150:complications / Q000401:mortality / Q000601:surgery*; D001026:Coronary Artery Bypass / Q000379:methods*; D023921:Coronary Stenosis / Q000150:complications / Q000401:mortality / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends; D013781:Texas / Q000453:epidemiology; D016896:Treatment Outcome; D055815:Young Adult