title: Treatment of laryngopharyngeal reflux: a comparison between domperidone plus omeprazole and omeprazole alone.
abstract: OBJECTIVE
  To evaluate the efficacy of domperidone in combination with omeprazole in the treatment of laryngopharyngeal reflux (LPR) compare to omeprazole alone.
  
  
  METHODS
  A prospective and randomized study included seventy patients with a reflux symptom index (RSI) 13 or more. They received either domperidone 10 mg thrice daily plus omeprazole 20 mg twice daily or omeprazole alone for three months. RSI was assessed at baseline and after three months of treatment.
  
  
  RESULTS
  Total RSI as well as several subscores were comparable between groups before the treatment. After three months of the treatment, moderate improvement of total RSI was shown in both groups (72.7%, 67.5%). The reduction of total RSI and individual subscores were statistically significant within each group (p < 0.001 each). Comparing between each treatment group, the mean difference of total RSI and individual subscores did not shown any statistically differences (p > 0.05 each) at the end of the study period.
  
  
  CONCLUSIONS
  Domperidone in combination with omeprazole is not superior to omeprazole alone in the treatment of LPR.
authors.affiliation: Department of Otolaryngology, Faculty of Medicine, Srinakharinwirot University, Bangkok, Thailand. niranhun@hotmail.com
authors.forename: Niran
authors.initials: N
authors.lastname: Hunchaisri
mesh_terms: D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D016009:Chi-Square Distribution; D004294:Domperidone / Q000627:therapeutic use*; D018492:Dopamine Antagonists / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D057045:Laryngopharyngeal Reflux / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000627:therapeutic use*; D011446:Prospective Studies; D016896:Treatment Outcome
chemical_list: D000897:Anti-Ulcer Agents; D018492:Dopamine Antagonists; D004294:Domperidone; D009853:Omeprazole