title: Therapeutic efficiency of antibiotics and prostaglandin F2α in postpartum dairy cows with clinical endometritis: an evidence-based evaluation.
abstract: The occurrence of vaginal discharge in postpartum dairy cows is generally diagnosed as clinical endometritis. This uterine condition is associated with reduced fertility and economic loss for the dairy industry. Therapeutic approaches include the systemic or intrauterine application of antibiotics or the injection of prostaglandin F2α and analogues to cause luteolysis and uterine contractions to evacuate the infected content. The treatment of clinical endometritis remains a subject of considerable controversy in the literature. Better understanding of the reproductive biology of normal versus abnormal uterine involution and immune mechanisms will allow more efficient diagnostic methods and a more efficient therapeutic approach.
authors.affiliation: Département des Sciences Cliniques, Faculté de Médecine Vétérinaire, Saint-Hyacinthe, Université de Montréal, 3200 rue Sicotte, CP 5000, Saint-Hyacinthe, Québec, Canada J2S 7C5. rejean.lefebvre@umontreal.ca
authors.forename: Rejean C
authors.initials: RC
authors.lastname: Lefebvre
authors.forename: Angelika E
authors.initials: AE
authors.lastname: Stock
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D015237:Dinoprost / Q000627:therapeutic use*; D004716:Endometritis / Q000188:drug therapy / Q000662:veterinary*; D019317:Evidence-Based Medicine; D005260:Female; D049590:Postpartum Period; D011247:Pregnancy; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D015237:Dinoprost