title: Prognostic analysis for treatment modalities in hepatocellular carcinomas with portal vein tumor thrombi.
abstract: OBJECTIVE
  To assess prognostic aspects of treatment modalities for cases of hepatocellular carcinoma (HCC) with portal vein tumor thrombi (PVTT).
  
  
  METHODS
  121 treated cases were retrospectively divided into five groups: 1 (liver transplantation); 2 (transcatheter arterial chemoembolization); 3 (hepatectomy plus thrombectomy); 4 (hepatectomy plus thrombectomy combined with adjuvant chemobiotherapy via portal vein); and 5 (conservative treatment). The Kaplan-Meier method with difference in survival estimated by Log-rank test was used to compare between groups.
  
  
  RESULTS
  Groups 1-5 had a significantly differing median survival times of 7, 7, 10, 16, 3 months (P<0.05), respectively. One- and three-year survival rates were 30.0% and 10.0%, 20.0% and 0.0%, 47.0% and 22.0%, 70% and 20%, and 12% and 4%.
  
  
  CONCLUSIONS
  Surgical resection combined with adjuvant chemotherapy via the portal vein is an effective and safe treatment modality for hepatocellular carcinoma with portal vein tumor thrombi.
authors.affiliation: Department of Hepatobiliary Surgery, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
authors.forename: Qi
authors.initials: Q
authors.lastname: Zhou
authors.forename: Yafeng
authors.initials: Y
authors.lastname: Wang
authors.forename: Xiangbing
authors.initials: X
authors.lastname: Zhou
authors.forename: Baogang
authors.initials: B
authors.lastname: Peng
authors.forename: Jianyong
authors.initials: J
authors.lastname: Yang
authors.forename: Lijian
authors.initials: L
authors.lastname: Liang
authors.forename: Jiaping
authors.initials: J
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D016461:Chemoembolization, Therapeutic; D017024:Chemotherapy, Adjuvant; D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D011169:Portal Vein / Q000473:pathology / Q000601:surgery*; D015996:Survival Rate; D017131:Thrombectomy; D020246:Venous Thrombosis / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D055815:Young Adult