title: Role of phosphoinositides at the neuronal synapse.
abstract: Synaptic transmission is amongst the most sophisticated and tightly controlled biological phenomena in higher eukaryotes. In the past few decades, tremendous progress has been made in our understanding of the molecular mechanisms underlying multiple facets of neurotransmission, both pre- and postsynaptically. Brought under the spotlight by pioneer studies in the areas of secretion and signal transduction, phosphoinositides and their metabolizing enzymes have been increasingly recognized as key protagonists in fundamental aspects of neurotransmission. Not surprisingly, dysregulation of phosphoinositide metabolism has also been implicated in synaptic malfunction associated with a variety of brain disorders. In the present chapter, we summarize current knowledge on the role of phosphoinositides at the neuronal synapse and highlight some of the outstanding questions in this research field.
authors.affiliation: Department of Pathology and Cell Biology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, 630 West 168th Street, P&S 12-420C, 10032, New York, USA.
authors.forename: Samuel G
authors.initials: SG
authors.lastname: Frere
authors.forename: Belle
authors.initials: B
authors.lastname: Chang-Ileto
authors.forename: Gilbert
authors.initials: G
authors.lastname: Di Paolo
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000503:physiopathology; D000818:Animals; D001692:Biological Transport; D002118:Calcium / Q000378:metabolism; D004314:Down Syndrome / Q000378:metabolism / Q000503:physiopathology; D005089:Exocytosis; D018698:Glutamic Acid / Q000378:metabolism; D006801:Humans; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D010716:Phosphatidylinositols / Q000737:chemistry / Q000378:metabolism*; D018091:Receptors, AMPA / Q000378:metabolism; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism; D050600:SNARE Proteins / Q000378:metabolism; D013569:Synapses / Q000737:chemistry / Q000378:metabolism*; D009435:Synaptic Transmission
chemical_list: D010716:Phosphatidylinositols; D018091:Receptors, AMPA; D016194:Receptors, N-Methyl-D-Aspartate; D050600:SNARE Proteins; D018698:Glutamic Acid; D002118:Calcium