title: Influence of polymers/excipients on development of agglomerated crystals of secnidazole by crystallo-co-agglomeration technique to improve processability.
abstract: BACKGROUND
  Direct tabletting is a need of Pharmaceutical industries. Poor mechanical properties of drug particles require wet granulation which is uneconomical, laborious, and tedious.
  
  
  OBJECTIVE
  Objective of this work was to study influence of various polymers/excipients on formation of directly compressible Crystallo-co-agglomerates (CCA) of water soluble drug Secnidazole (hydroxy-2-propyl)-1-methyl-2-nitro-5-imidazole), an antimicrobial agent.
  
  
  METHODS
  Acetone-petroleum ether system was used to develop CCA of drug in the presence of polymers/excipients. Clarity of the supernatant was considered an endpoint for completion of agglomeration. The prepared CCA were subjected for topographic, micromeritic, mechanical, compressional, and drug release properties.
  
  
  RESULTS
  The process yielded ~92 to 98% wt/wt CCA containing secnidazole with the diameter between 0.2 and 0.7 mm. CCA showed excellent flow, packability, compatibility, and crushing strength. Heckel plot showed lower σ(0) and higher tensile strength with lower elastic recovery (0.55-1.28%) of CCA. Dissolution profile of CCA was improved. Differential scanning calorimetry , fourier transform infra-red, and x-ray diffractometry results showed absence of drug-excipient interaction.
  
  
  CONCLUSIONS
  Matrix beads were generated with uniform dispersion of crystallized drug. Excellent flow, packability, and compactability were due to sphericity of agglomerates. Higher crushing strength of CCA was an indication of good handling qualities. Lower σ(0), higher tensile strength, and lower elastic recovery indicated excellent compressibility of agglomerates. Improvement in dissolution profile was due to porous nature of CCA.
  
  
  CONCLUSIONS
  Excipients and polymers can play a key role to prepare CCA, an excellent alternative to wet granulation process to prepare particles for direct compression.
authors.affiliation: Department of Pharmaceutical Sciences, Saurashtra University, Rajkot, Gujarat, India. rmihir@yahoo.com
authors.forename: Mihir K
authors.initials: MK
authors.lastname: Raval
authors.forename: Kishor R
authors.initials: KR
authors.lastname: Sorathiya
authors.forename: Narendra P
authors.initials: NP
authors.lastname: Chauhan
authors.forename: Jaydeep M
authors.initials: JM
authors.lastname: Patel
authors.forename: Rajesh K
authors.initials: RK
authors.lastname: Parikh
authors.forename: Navin R
authors.initials: NR
authors.lastname: Sheth
mesh_terms: D000981:Antiprotozoal Agents / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D003460:Crystallization / Q000379:methods; D004339:Drug Compounding / Q000379:methods*; D005079:Excipients / Q000737:chemistry*; D008795:Metronidazole / Q000031:analogs & derivatives* / Q000737:chemistry; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*
chemical_list: D000981:Antiprotozoal Agents; D005079:Excipients; D011108:Polymers; D008795:Metronidazole; C016724:secnidazole