title: [The evaluation of apoptosis in peripheral blood lymphocytes in laryngeal cancer patients].
abstract: The laryngeal cancer is the most often cancer among others in head and neck region. It occurs mostly among 55 and 69. Its development depends on immunological state of the body. Vitality of the immunological system cells was considered due to growth, treatment sensitivity and prognosis of some neoplasms. The aim of this work were estimation and comparison the phenomenon of lymphocytes T and B apoptosis in laryngeal cancer patients treated with surgery and radiotherapy.
  
  
  METHODS
  The material were 30 patients hospitalized in The Department of Otolaryngology Medical University of Lublin. They all were treated with surgery or surgery and radiotherapy. Apoptosis was estimated on different stages of the treatment process. All samples were examined with the flow cytometry method. The control group were 21 patients hospitalized because of the suspicion of the apnea syndrome, which wasn't confirmed with polysomnographic examination.
  
  
  RESULTS
  Results of this study show significantly increasing percentage of peripheral blood apoptotic B (CD19+) cells caused by surgical treatment. The results considering radiotherapy showed different influence on the phenomenon of immunological cells apoptosis, still those results weren't significant.
  
  
  CONCLUSIONS
  The surgical treatment causes increased amount of apoptotic peripheral blood lymphocytes.
authors.affiliation: Katedra i Klinika Otolaryngologii i Onkologii Laryngologicznej Uniwersytetu Medycznego w Lublinie. misia_w1@wp.pl
authors.forename: Beata
authors.initials: B
authors.lastname: Piechnik
authors.forename: Paulina
authors.initials: P
authors.lastname: Wdowiak
authors.forename: Magdalena
authors.initials: M
authors.lastname: Wasiak
authors.forename: Sebastian
authors.initials: S
authors.lastname: Radej
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Lasota
authors.forename: Janusz
authors.initials: J
authors.lastname: Klatka
mesh_terms: D000368:Aged; D018941:Antigens, CD19 / Q000276:immunology; D017209:Apoptosis; D001402:B-Lymphocytes / Q000473:pathology*; D017252:CD3 Complex / Q000276:immunology; D016827:CD8 Antigens / Q000276:immunology; D016022:Case-Control Studies; D005434:Flow Cytometry; D006801:Humans; D007822:Laryngeal Neoplasms / Q000276:immunology / Q000473:pathology* / Q000628:therapy*; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011044:Poland; D013601:T-Lymphocytes / Q000473:pathology*
chemical_list: D018941:Antigens, CD19; D017252:CD3 Complex; D016827:CD8 Antigens