title: Contributions of mass spectrometry-based proteomics to defining cellular mechanisms and diagnostic markers for systemic lupus erythematosus.
abstract: Systematic lupus erythematosus (SLE) is a complex disease for which molecular diagnostics are limited and pathogenesis is not clearly understood. Important information is provided in this regard by identification and characterization of more specific molecular and cellular targets in SLE immune cells and target tissue and markers of early-onset and effective response to treatment of SLE complications. In recent years, advances in proteomic technologies and applications have facilitated such discoveries. Here we provide a review of insights into SLE pathogenesis, diagnosis and treatment that have been provided by mass spectrometry-based proteomic approaches.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Louisville School of Medicine, 570 South Preston St, Baxter Research Building I, Room 204E, Louisville, KY 40202, USA.
authors.forename: Erik A
authors.initials: EA
authors.lastname: Korte
authors.forename: Patrick M
authors.initials: PM
authors.lastname: Gaffney
authors.forename: David W
authors.initials: DW
authors.lastname: Powell
mesh_terms: D015415:Biomarkers / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000378:metabolism* / Q000628:therapy; D013058:Mass Spectrometry / Q000379:methods*; D020543:Proteome / Q000032:analysis / Q000378:metabolism; D040901:Proteomics / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; D020543:Proteome