title: Pathophysiologic mechanisms of calcific aortic stenosis.
abstract: Calcific aortic stenosis (CAS) comprises the leading indication for valve replacement in the Western world. Until recently, progressive calcification was considered to be a passive process. Emerging evidence, however, suggests that degenerative aortic stenosis constitutes an active process involving stimulation of several pathophysiologic pathways such as inflammation and osteogenesis. In addition, CAS and atherosclerosis share common features regarding histopathology of lesions. These novel data raise a new perspective on the prevention and treatment of disease. The current article reviews the most important pathophysiologic mechanisms of senile aortic stenosis.
authors.affiliation: Department of Cardiology, Athens General Hospital, Mesogeion Avenue, 154, 15669 Athens, Greece. aalexop@upatras.gr
authors.forename: Alexandros
authors.initials: A
authors.lastname: Alexopoulos
authors.forename: Andreas
authors.initials: A
authors.lastname: Kaoukis
authors.forename: Helen
authors.initials: H
authors.lastname: Papadaki
authors.forename: Vlassios
authors.initials: V
authors.lastname: Pyrgakis
mesh_terms: D000818:Animals; D001024:Aortic Valve Stenosis / Q000503:physiopathology* / Q000517:prevention & control / Q000628:therapy; D050197:Atherosclerosis / Q000473:pathology*; D002114:Calcinosis / Q000503:physiopathology* / Q000517:prevention & control / Q000628:therapy; D019918:Heart Valve Prosthesis Implantation / Q000379:methods; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D010012:Osteogenesis