title: Atropodiastereoselectivity in solid state BINOL synthesis: leads from the estradiol platform.
abstract: A novel functionalized steroidal BINOL scaffold is produced via a remarkable sequence of dehydrogenation, chlorination and atroposelective phenolic coupling steps. Its formation is straightforwardly obtained in a one-step synthesis under solid state conditions and in the absence of chiral additives.
authors.affiliation: Department of Chemical Sciences, University of Naples Federico II, Complesso Universitario Monte S. Angelo, Via Cintia 4, I-80126 Naples, Italy.
authors.forename: Liliana
authors.initials: L
authors.lastname: Lista
authors.forename: Alessandro
authors.initials: A
authors.lastname: Pezzella
authors.forename: Paola
authors.initials: P
authors.lastname: Manini
authors.forename: Alessandra
authors.initials: A
authors.lastname: Napolitano
authors.forename: Marco
authors.initials: M
authors.lastname: d'Ischia
mesh_terms: D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D004958:Estradiol / Q000737:chemistry*; D009284:Naphthols / Q000138:chemical synthesis* / Q000737:chemistry*; D010084:Oxidation-Reduction; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: C406944:BINOL, naphthol; D009284:Naphthols; D004958:Estradiol