title: Inflammation in sporadic colorectal cancer.
abstract: Chronic inflammation plays a pivotal role in the development of colorectal cancer (CRC) in patients with inflammatory bowel disease (IBD). An orchestrated interplay of immune cells with numerous inflammatory mediators including reactive oxygen and nitrogen species, cyclooxygenase 2, and several cytokines promotes colitis-associated cancer (CAC). Recent findings have shown that inflammatory pathways not only are important in the development of CAC but are also involved in the pathogenesis of sporadic CRC. Hereby,  we review the existing experimental and clinical evidence that suggest a link between inflammation and tumorigenesis in sporadic CRC.
authors.affiliation: Digestive Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Shirin
authors.initials: S
authors.lastname: Moossavi
authors.forename: Faraz
authors.initials: F
authors.lastname: Bishehsari
mesh_terms: D002471:Cell Transformation, Neoplastic / Q000276:immunology*; D015179:Colorectal Neoplasms / Q000209:etiology / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000276:immunology* / Q000378:metabolism; D018836:Inflammation Mediators / Q000276:immunology*; D015212:Inflammatory Bowel Diseases / Q000276:immunology
chemical_list: D018836:Inflammation Mediators