title: Principles of percutaneous paravalvular leak closure.
abstract: Paravalvular regurgitation affects 5% to 17% of all surgically implanted prosthetic heart valves. Patients who have paravalvular regurgitation can be asymptomatic or present with hemolysis or heart failure, or both. Reoperation is associated with increased morbidity and is not always successful because of underlying tissue friability, inflammation, or calcification. Comprehensive echocardiographic imaging with transthoracic and real-time 3-dimensional transesophageal echocardiography is key for characterizing the defect location, size, and shape. For paramitral defects, an antegrade transseptal approach can usually be guided by biplane fluoroscopy, and real-time 3-dimensional transesophageal echocardiography can usually be performed successfully. Alternative approaches to paramitral defects include retrograde transaortic cannulation or transapical access and retrograde cannulation. For oblong or crescentic defects, the simultaneous or sequential deployment of 2 smaller devices, as opposed to 1 large device, results in a higher degree of procedural success and safety because the risk of impingement on the prosthetic leaflets is minimized. Most para-aortic defects can be approached in a retrograde manner and closed with a single device. With careful anatomical assessment, procedural planning, and procedural execution, successful closure rates of 90% or more should be attainable with a low risk of device impingement on the prosthetic valve or embolization.
authors.affiliation: Division of Cardiovascular Diseases, Mayo Clinic, Rochester, Minnesota 55905, USA. rihal@mayo.edu
authors.forename: Charanjit S
authors.initials: CS
authors.lastname: Rihal
authors.forename: Paul
authors.initials: P
authors.lastname: Sorajja
authors.forename: Jeffrey D
authors.initials: JD
authors.lastname: Booker
authors.forename: Donald J
authors.initials: DJ
authors.lastname: Hagler
authors.forename: Allison K
authors.initials: AK
authors.lastname: Cabalka
mesh_terms: D000368:Aged; D001011:Aorta / Q000473:pathology; D017548:Echocardiography, Transesophageal / Q000295:instrumentation; D005260:Female; D006349:Heart Valve Diseases / Q000601:surgery*; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D008297:Male; D011300:Preoperative Care; D055989:Septal Occluder Device; D014481:United States