title: Przewalskone: a cytotoxic adduct of a danshenol type terpenoid and an icetexane diterpenoid via hetero-Diels-Alder reaction from Salvia przewalskii.
abstract: Przewalskone (1), an unprecedented adduct of two different terpenoid units via a hetero-Diels-Alder cycloaddition, was isolated from the roots of Salvia przewalskii. The structure and absolute configurations were elucidated by extensive analysis of NMR spectra and crystal X-ray diffractions. Compound 1 exhibited significant cytotoxicities against five human cancer lines in vitro (IC(50) 0.69-2.35 μM).
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, PR China. xugang008@mail.kib.ac.cn
authors.forename: Gang
authors.initials: G
authors.lastname: Xu
authors.forename: Xing-Wei
authors.initials: XW
authors.lastname: Yang
authors.forename: Chun-Yan
authors.initials: CY
authors.lastname: Wu
authors.forename: Xiao-Nian
authors.initials: XN
authors.lastname: Li
authors.forename: Jia
authors.initials: J
authors.lastname: Su
authors.forename: Xu
authors.initials: X
authors.lastname: Deng
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Hong-Bo
authors.initials: HB
authors.lastname: Qin
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Yang
authors.forename: Qin-Shi
authors.initials: QS
authors.lastname: Zhao
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D045744:Cell Line, Tumor; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D006801:Humans; D020128:Inhibitory Concentration 50; D027544:Salvia / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D004224:Diterpenes; C574068:przewalskone