title: Heart failure treated with low-dose milrinone in a full-term newborn.
abstract: A term newborn with a hypocontractile myocardium complicating             persistent pulmonary hypertension of the newborn was successfully treated with             a low-dose phosphodiesterase III inhibitor milrinone. Echocardiography diagnosed             heart failure with a left ventricular ejection fraction of 35% and a left ventricular             shortening fraction of 18% and severe persistent pulmonary hypertension of the             newborn with oxygenation index of 28. Milrinone was started at an initial dose             of 50 mcg/kg, followed by continuous infusion of 0.20 mcg/kg/min. With lowdose             milrinone oxygenation index decreased to 3 within 6 hours, left ventricular             ejection fraction and left ventricular shortening fraction increased to 57%, and 30%,             respectively. Low doses of milrinone might be promising in the treatment of heart             failure and persistent pulmonary hypertension of the newborn in term newborns.
authors.affiliation: Department of Neonatology, Thomayer Hospital, Prague, Czech Republic.
authors.forename: S
authors.initials: S
authors.lastname: Sebková
authors.forename: V
authors.initials: V
authors.lastname: Tomek
authors.forename: P
authors.initials: P
authors.lastname: Zemanová
authors.forename: J
authors.initials: J
authors.lastname: Janota
mesh_terms: D002316:Cardiotonic Agents / Q000008:administration & dosage*; D005260:Female; D006333:Heart Failure / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007231:Infant, Newborn; D020105:Milrinone / Q000008:administration & dosage*; D010547:Persistent Fetal Circulation Syndrome / Q000150:complications / Q000188:drug therapy; D058987:Phosphodiesterase 3 Inhibitors / Q000008:administration & dosage*; D014665:Vasodilator Agents / Q000008:administration & dosage*
chemical_list: D002316:Cardiotonic Agents; D058987:Phosphodiesterase 3 Inhibitors; D014665:Vasodilator Agents; D020105:Milrinone