title: Hemofiltration circuit use beyond 72 hours in pediatric continuous renal replacement therapy.
abstract: BACKGROUND
  During continuous renal replacement therapy (CRRT), hemofiltration circuits ideally are changed after 72 h since tubing integrity and flow rates are not guaranteed after this time interval. This potential risk must be weighed against the risk of hypotension during elective circuit changes in the unstable patient. The aim of this study was to examine the safety of circuits used beyond 72 h in pediatric CRRT.
  
  
  METHODS
  A retrospective chart review of all patients who underwent CRRT at our institution from January 2003 to October 2005 was performed. Procedures were divided into standard (≤72 h) and extended (>72 h) circuit duration groups. Patients who had more than one CRRT procedure (n=13) were excluded from study.
  
  
  RESULTS
  71 CRRT procedures were performed for 71 patients. A total of 254 circuits were used, of which 64 (25%) were used for >72 h. For circuits >72 h, the mean duration of use was 5.5 days ± 1.8 (range 4-11). There were no differences between the groups in age (p=0.12), weight (p=0.48), diagnosis (p=0.21), CRRT indication (p=0.07), CRRT mode (p=0.37), anticoagulation (p=0.53), blood flow rate (p=0.06), replacement rate (p=0.50) or dialysate rate (p=0.89). There were no incidents of membrane or tubing rupture in either group.
  
  
  CONCLUSIONS
  Use of hemofiltration circuits beyond 72 h may be safe in pediatric patients undergoing CRRT without increased risk of tubing rupture. Our data suggest a need to redefine the limits of prolonged circuit use in pediatric CRRT.
authors.affiliation: Children's Memorial Hospital, Northwestern University, Chicago, Illinois 60614, USA. fali@childrensmemorial.org
authors.forename: Farah N
authors.initials: FN
authors.lastname: Ali
authors.forename: Jerome C
authors.initials: JC
authors.lastname: Lane
mesh_terms: D000293:Adolescent; D000367:Age Factors; D016009:Chi-Square Distribution; D002641:Chicago; D002648:Child; D002675:Child, Preschool; D004867:Equipment Design; D004868:Equipment Failure; D006440:Hemofiltration / Q000009:adverse effects / Q000295:instrumentation; D006801:Humans; D007223:Infant; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult