title: Analysis of the IL28RA locus as genetic risk factor for multiple sclerosis.
abstract: Recently, we reported an association between a SNP in IL28RA and MS. Here, we performed a fine-mapping of the IL28RA locus by genotyping 10 haplotype-tagging SNPs in a Basque-Spanish population. In addition, based on shared genetic risk loci between autoimmune diseases, a psoriasis-associated SNP located at this locus, rs4649203, was genotyped in four independent populations, comprising a total of 2582 cases and 2614 controls. We did not find any consistent association between IL28RA and MS in these populations, suggesting that, although it may play a role in other autoimmune diseases, this gene is unlikely of general relevance to MS pathogenesis.
authors.affiliation: Neurogenomiks Group, Universidad del País Vasco-UPV/EHU, Leioa, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Lopez de Lapuente
authors.forename: I
authors.initials: I
authors.lastname: Alloza
authors.forename: R
authors.initials: R
authors.lastname: Goertsches
authors.forename: U K
authors.initials: UK
authors.lastname: Zettl
authors.forename: E
authors.initials: E
authors.lastname: Urcelay
authors.forename: R
authors.initials: R
authors.lastname: Arroyo
authors.forename: M
authors.initials: M
authors.lastname: Comabella
authors.forename: X
authors.initials: X
authors.lastname: Montalban
authors.forename: A
authors.initials: A
authors.lastname: Antigüedad
authors.forename: K
authors.initials: K
authors.lastname: Vandenbroeck
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D056426:Genetic Loci / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology; D011110:Polymorphism, Genetic / Q000235:genetics*; D018121:Receptors, Cytokine / Q000235:genetics*; D012307:Risk Factors; D055815:Young Adult
chemical_list: D018121:Receptors, Cytokine; C471046:interleukin 28alpha receptor