title: Polymorphisms of TREH, IL4R and CCDC26 genes associated with risk of glioma.
abstract: BACKGROUND
  Glioma is one of the most aggressive human tumors; however, little is known about its genetic risk factors. The role of heredity is likely to be explained by combinations of common low-risk variants. Previous studies have indicated that more than 100 single nucleotide polymorphisms (SNPs) are associated with the risk of glioma.
  
  
  METHODS
  To further investigate how and to what extent these SNPs contribute to glioma susceptibility in a Chinese population, we analyzed 43 SNPs of 226 glioma patients and 254 normal people in order to evaluate the associations between SNPs and the risk of glioma.
  
  
  RESULTS
  Overall, we found three protective alleles for glioma in patients: the allele "G" of rs1801275 in the IL4R gene by allele model (odds ratio [OR], 0.71; 95% confidence interval [CI], 0.50-0.99; P=0.04) and dominant model (OR, 0.67; 95% CI, 0.46-0.99; P=0.04) analysis respectively, the allele "T" of rs17748 in the TREH gene by recessive model (OR, 0.48; 95% CI, 0.23-1.01; P=0.05) analysis, and the allele "G" of rs6470745 in CCDC26 gene by recessive model (OR, 0.48; 95% CI, 0.26-0.89; P=0.02) analysis.
  
  
  CONCLUSIONS
  This study provides evidence for three glioma susceptibility genes - TREH, IL4R and CCDC26 - in a Chinese population; this may shed light on molecular markers of glioma susceptibility and could therefore be used as a diagnostic and prognostic marker for glioma patients in clinical study.
authors.affiliation: Medical Center of Tangdu Hospital, The Fourth Military Medical University, Xi'an, China.
authors.forename: Shanqu
authors.initials: S
authors.lastname: Li
authors.forename: Tianbo
authors.initials: T
authors.lastname: Jin
authors.forename: Jiayi
authors.initials: J
authors.lastname: Zhang
authors.forename: Huiling
authors.initials: H
authors.lastname: Lou
authors.forename: Bo
authors.initials: B
authors.lastname: Yang
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.forename: Chao
authors.initials: C
authors.lastname: Chen
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D002681:China; D005260:Female; D020022:Genetic Predisposition to Disease; D005910:Glioma / Q000235:genetics*; D006801:Humans; D053662:Interleukin-4 Receptor alpha Subunit / Q000235:genetics*; D047908:Intracellular Signaling Peptides and Proteins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D020641:Polymorphism, Single Nucleotide; D062085:RNA, Long Noncoding; D014198:Trehalase / Q000235:genetics*; D055815:Young Adult
chemical_list: C504000:IL4R protein, human; D053662:Interleukin-4 Receptor alpha Subunit; D047908:Intracellular Signaling Peptides and Proteins; D062085:RNA, Long Noncoding; C000613877:long noncoding RNA CCDC26, human; D014198:Trehalase