title: Autoimmune polyendocrine syndrome-3 in a patient with late-onset multiple sclerosis.
abstract: We present here the rare case of a 73-year-old patient with very late-onset multiple sclerosis who developed autoimmune polyendocrine syndrome (APS)-3. Despite only a few reports describing the association between multiple sclerosis and APS, both of these diseases have been shown to be associated with HLA-DR4. Intriguingly, the HLA genotype profile of this patient included HLA-DR4 which, fine mapped to the DRB1*0405-DQA1*0303-DQB1*0401 extended haplotype, reported to be a susceptibility haplotype for APS-3 in Japan. This unique genetic background might explain the clinical picture of this patient.
authors.affiliation: Department of Neurology, Musashino Red Cross Hospital, Kyonan-cho, Musashino, Tokyo, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Yokote
authors.forename: Miki
authors.initials: M
authors.lastname: Nagasawa
authors.forename: Masahiko
authors.initials: M
authors.lastname: Ichijo
authors.forename: Takeshi
authors.initials: T
authors.lastname: Amino
authors.forename: Hiroto
authors.initials: H
authors.lastname: Fujigasaki
mesh_terms: D017668:Age of Onset; D000368:Aged; D044466:Asian People / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D015804:HLA-DR4 Antigen / Q000235:genetics; D006801:Humans; D009103:Multiple Sclerosis / Q000150:complications*; D016884:Polyendocrinopathies, Autoimmune / Q000150:complications* / Q000175:diagnosis / Q000235:genetics*
chemical_list: D015804:HLA-DR4 Antigen