title: In vitro release profile of anti-ulcer drug rabeprazole from biocompatible psyllium-PVA hydrogels.
abstract: The present article discusses the synthesis, characterization and haemocompatibility behaviour of the psyllium-PVA hydrogels prepared by chemical method in the presence of N,N'-methylenebisacrylamide. These hydrogels have been characterized by Fourier Transform infrared spectroscopy, thermo gravimetric analysis, swelling and drug release studies. The release of model drug rabeprazole sodium from the drug loaded hydrogels occurred through non-Fickian diffusion mechanism. Psyllium itself acts as anti-ulcer agent and release of rabeprazole from the drug loaded hydrogels may enhance the curing potential of the drug delivery device. The haemocompatibility was evaluated by studying the blood interactions with hydrogels with reference to thrombogenicity and haemolytic potential. Thrombogenicity results indicate that hydrogels are non-thrombogenic as the weight of clot formed and thrombus percentage for hydrogels was less than the positive control. The haemolytic index has been observed <5%. These observations indicate that these hydrogels are haemo-compatible and hence could be used for oral administration of antiulcer drugs.
authors.affiliation: Department of Chemistry, Himachal Pradesh University, Shimla, India. baljitsinghhpu@yahoo.com
authors.forename: Baljit
authors.initials: B
authors.lastname: Singh
authors.forename: Harinder
authors.initials: H
authors.lastname: Lal
authors.forename: Lok
authors.initials: L
authors.lastname: Pal
authors.forename: Vikrant
authors.initials: V
authors.lastname: Sharma
mesh_terms: D053799:2-Pyridinylmethylsulfinylbenzimidazoles / Q000008:administration & dosage* / Q000493:pharmacokinetics; D000897:Anti-Ulcer Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001672:Biocompatible Materials; D020100:Hydrogels; D066298:In Vitro Techniques; D011142:Polyvinyl Alcohol; D011620:Psyllium; D064750:Rabeprazole; D017550:Spectroscopy, Fourier Transform Infrared; D013818:Thermogravimetry
chemical_list: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000897:Anti-Ulcer Agents; D001672:Biocompatible Materials; D020100:Hydrogels; D064750:Rabeprazole; D011620:Psyllium; D011142:Polyvinyl Alcohol