title: Comparison of drug-eluting stents with bare metal stents in patients with ST-segment elevation myocardial infarction.
abstract: OBJECTIVE
  To evaluate safety and effectiveness of early generation drug-eluting stents (DES) compared with bare-metal stents (BMS) in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI), and to determine whether benefits and risks vary over time.
  
  
  RESULTS
  We performed a meta-analysis of 15 randomized controlled trials enrolling a total of 7867 patients comparing first-generation FDA-approved DES with BMS in patients with STEMI. Random effect models were used to assess differences in outcomes between DES and BMS among different time periods with regard to the pre-specified primary outcomes stent thrombosis (ST) and target vessel revascularization (TVR). The overall risk of definite ST was similar for DES and BMS [risk ratio (RR) = 1.08, 95% CI 0.82-1.43]. However, there were time-dependent effects, with a RR of 0.80 during the first year (95% CI 0.58-1.12) and 2.10 during subsequent years (95% CI 1.20-3.69), with a positive test for interaction between RR of ST and time (P for interaction = 0.009). Results were similar for definite or probable ST (P for interaction = 0.015). In the overall analysis, TVR was performed less frequently in patients with DES when compared with BMS (RR 0.51, 95% CI 0.43-0.61), with a greater benefit in the first year (RR 0.46, 95% CI 0.38-0.55) when compared with subsequent years (RR 0.75, 95% CI 0.59-0.94; P for interaction = 0.007).
  
  
  CONCLUSIONS
  An early benefit of early generation DES in primary PCI for STEMI with a reduction in TVR and a trend towards less definite ST is offset in subsequent years by an increased risk of very late ST.
authors.affiliation: Department of Cardiology,  Bern University Hospital, Bern,  Switzerland.
authors.forename: Bindu
authors.initials: B
authors.lastname: Kalesan
authors.forename: Thomas
authors.initials: T
authors.lastname: Pilgrim
authors.forename: Katja
authors.initials: K
authors.lastname: Heinimann
authors.forename: Lorenz
authors.initials: L
authors.lastname: Räber
authors.forename: Giulio G
authors.initials: GG
authors.lastname: Stefanini
authors.forename: Marco
authors.initials: M
authors.lastname: Valgimigli
authors.forename: Bruno R
authors.initials: BR
authors.lastname: da Costa
authors.forename: François
authors.initials: F
authors.lastname: Mach
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Lüscher
authors.forename: Bernhard
authors.initials: B
authors.lastname: Meier
authors.forename: Stephan
authors.initials: S
authors.lastname: Windecker
authors.forename: Peter
authors.initials: P
authors.lastname: Jüni
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000379:methods; D054855:Drug-Eluting Stents; D005260:Female; D006083:Graft Occlusion, Vascular / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000628:therapy*; D061366:Numbers Needed To Treat; D016032:Randomized Controlled Trials as Topic; D012307:Risk Factors; D015607:Stents; D016896:Treatment Outcome