title: Relevance of sensitization to occupational allergy and asthma in the detergent industry.
abstract: There exists considerable historic experience of the relationship between exposure and both the induction of sensitization and the elicitation of respiratory symptoms from industrial enzymes of bacterial and fungal origin used in a wide variety of detergent products. The detergent industry in particular has substantial experience of how the control of exposure leads to limitation of sensitization with low risk of symptoms. However, the experience also shows that there are substantial gaps in knowledge, even when the potential occupational allergy problem is firmly under control, and also that the relationship between exposure and sensitization can be hard to establish. The latter aspect includes a poor appreciation of how peak exposures and low levels of exposure over time contribute to sensitization. Furthermore, while a minority of workers develop specific IgE, essentially none appear to have symptoms, a situation which appears to contradict the allergy dogma that, once sensitized, an individual will react to much lower levels of exposure. For enzymes, the expression of symptoms occurs at similar or higher levels than those that cause induction. In spite of some knowledge gaps, medical surveillance programs and constant air monitoring provide the tools for successful management of enzymes in the occupational setting. Ultimately, the knowledge gained from the occupational setting facilitates the completion of safety assessments for consumer exposure to detergent enzymes. Such assessments have been proven to be correct by the decades of safe use both occupationally and in consumer products.
authors.affiliation: DABMEB Consultancy Ltd, Sharnbrook, Bedfordshire, UK. dabmebconsultancyltd@me.com
authors.forename: David
authors.initials: D
authors.lastname: Basketter
authors.forename: Ninna
authors.initials: N
authors.lastname: Berg
authors.forename: Francis H
authors.initials: FH
authors.lastname: Kruszewski
authors.forename: Katherine
authors.initials: K
authors.lastname: Sarlo
authors.forename: Beth
authors.initials: B
authors.lastname: Concoby
mesh_terms: D001249:Asthma / Q000139:chemically induced / Q000453:epidemiology / Q000276:immunology; D001426:Bacterial Proteins / Q000009:adverse effects / Q000276:immunology; D002617:Chemical Industry; D003902:Detergents / Q000009:adverse effects*; D004798:Enzymes / Q000009:adverse effects / Q000276:immunology; D005260:Female; D005656:Fungal Proteins / Q000009:adverse effects / Q000276:immunology; D006801:Humans; D008297:Male; D016273:Occupational Exposure / Q000009:adverse effects*
chemical_list: D001426:Bacterial Proteins; D003902:Detergents; D004798:Enzymes; D005656:Fungal Proteins