title: Genetic copy number variants in myocardial infarction patients with hyperlipidemia.
abstract: BACKGROUND
  Cardiovascular disease is the chief cause of death in Taiwan and many countries, of which myocardial infarction (MI) is the most serious condition. Hyperlipidemia appears to be a significant cause of myocardial infarction, because it causes atherosclerosis directly. In recent years, copy number variation (CNV) has been analyzed in genomewide association studies of complex diseases. In this study, CNV was analyzed in blood samples and SNP arrays from 31 myocardial infarction patients with hyperlipidemia.
  
  
  RESULTS
  We identified seven CNV regions that were associated significantly with hyperlipidemia and myocardial infarction in our patients through multistage analysis (P<0.001), at 1p21.3, 1q31.2 (CDC73), 1q42.2 (DISC1), 3p21.31 (CDCP1), 10q11.21 (RET) 12p12.3 (PIK3C2G) and 16q23.3 (CDH13), respectively. In particular, the CNV region at 10q11.21 was examined by  quantitative real-time PCR, the results of which were consistent with  microarray findings.
  
  
  CONCLUSIONS
  Our preliminary results constitute an alternative method of evaluating the relationship between CNV regions and cardiovascular disease. These susceptibility CNV regions may be used as biomarkers for early-stage diagnosis of hyperlipidemia and myocardial infarction, rendering them valuable for further research and discussion.
authors.affiliation: Department of Information Engineering and Computer Science, Feng Chia University, Taichung City, Taiwan.
authors.forename: Wei-Chung
authors.initials: WC
authors.lastname: Shia
authors.forename: Tien-Hsiung
authors.initials: TH
authors.lastname: Ku
authors.forename: Yu-Ming
authors.initials: YM
authors.lastname: Tsao
authors.forename: Chien-Hsun
authors.initials: CH
authors.lastname: Hsia
authors.forename: Yung-Ming
authors.initials: YM
authors.lastname: Chang
authors.forename: Ching-Hui
authors.initials: CH
authors.lastname: Huang
authors.forename: Yeh-Ching
authors.initials: YC
authors.lastname: Chung
authors.forename: Shih-Lan
authors.initials: SL
authors.lastname: Hsu
authors.forename: Kae-Woei
authors.initials: KW
authors.lastname: Liang
authors.forename: Fang-Rong
authors.initials: FR
authors.lastname: Hsu
mesh_terms: D000328:Adult; D000368:Aged; D002784:Cholesterol / Q000097:blood; D056915:DNA Copy Number Variations; D005260:Female; D055106:Genome-Wide Association Study; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications* / Q000235:genetics*; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications* / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
chemical_list: D008077:Lipoproteins, LDL; D002784:Cholesterol