title: Importance of CYP1A1 polymorphism and its transcriptional regulation in ovarian and endometrial cancer.
abstract: Human cytochrome P450 1A 1 is one of the most important enzymes participating in human carcinogenesis because it metabolites several procarcinogens to active carcinogenic metabolites. Additionally enzymes of CYP450 family play an important role in estrogenes catabolization (17-beta-estradiol and estron) to intermediate products (2-, 4-hydroxyestradiol and 2-, 4-hydroxyestrone) including CYP1A1 that catalyses hydroxylation to 2-hydroxyestrogens in the endometrium. Derivates of these compounds (4-hydroxyestrogens) are carcinogenic and could induce DNA damage leading to tumour transformation. The presence of CYP1A1 enzyme in genital tract tissues could induce chemical carcinogenesis initiating cancer development. Recent studies also confirmed the role of CYP1A1 in the development of ovarian and endometrial cancer in humans. The presence of mutated CYP1A1 polymorphic variants influencing the CYP1A 1 activity could be responsible for different interindividual susceptibility to genital cancers in women.
authors.affiliation: Laboratory of Experimental Pharmacogenetics, Department of Clinical Pharmacy and Biopharmacy, Poznan University of Medical Sciences, Poznan, Poland. pmm@post.pl
authors.forename: Przemysław M
authors.initials: PM
authors.lastname: Mrozikiewicz
authors.forename: Edmund
authors.initials: E
authors.lastname: Grześkowiak
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Seremak-Mrozikiewicz
authors.forename: Anna
authors.initials: A
authors.lastname: Bogacz
authors.forename: Magdalena
authors.initials: M
authors.lastname: Barlik
authors.forename: Andrzej
authors.initials: A
authors.lastname: Semczuk
authors.forename: Joann
authors.initials: J
authors.lastname: Bartkowiak-Wieczorek
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Drews
mesh_terms: D000483:Alleles; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D016889:Endometrial Neoplasms / Q000201:enzymology / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D009154:Mutation; D010051:Ovarian Neoplasms / Q000201:enzymology / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
chemical_list: D019363:Cytochrome P-450 CYP1A1