title: [Prevention of acute stress ulcer and gastrointestinal bleeding in patients with acute necrotizing pancreatitis].
abstract: We aimed to compare the efficiency of drugs for prevention a gastrointestinal bleeding.
  
  
  OBJECTIVE
  The results of prospective and retrospective clinical study of 51 patients with acute necrotizing pancreatitis ANP. They were distributed assigned depending on the drug for the prevention of gastrointestinal bleeding in the first group (n = 39) used omeprazole (80 mg/day); in second (n = 12) pantoprazole (80 mg/day). The mean age (47,9 +/- 10,6 +/- 9,2) years, the severity of disease (average rating of APACHE II classification system 16,7 +/- 4,5 vs. 14,8 +/- 3,4) were similar. Our data discover that there no statistical difference between groups in bleeding rate.
  
  
  CONCLUSIONS
  pantoprazole can be used for prevention of hemorrhagic complication of stress ulcer in patients with necrotizing pancreatitis. A high percentage of hidden blood loss confirms the need for drugs with high therapeutic potential
mesh_terms: D053799:2-Pyridinylmethylsulfinylbenzimidazoles / Q000627:therapeutic use; D000328:Adult; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000627:therapeutic use; D019283:Pancreatitis, Acute Necrotizing / Q000150:complications* / Q000503:physiopathology; D000077402:Pantoprazole; D010437:Peptic Ulcer / Q000209:etiology / Q000517:prevention & control*; D011446:Prospective Studies; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D012189:Retrospective Studies; D012720:Severity of Illness Index
chemical_list: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000897:Anti-Ulcer Agents; D054328:Proton Pump Inhibitors; D000077402:Pantoprazole; D009853:Omeprazole