title: Modeling Parkinson's disease in primates: The MPTP model.
abstract: The 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) primate models of Parkinson's disease (PD) reproduce most, although not all, of the clinical and pathological hallmarks of PD. The present contribution presents the possibilities offered by the MPTP monkey models of PD to readers with minimal knowledge of PD, emphasizing the diversity of species, route and regimen of administration, symptoms and pathological features. Readers would eventually find out that there is not a single MPTP monkey model of PD but instead MPTP monkey models of PD, each addressing a specific experimental need.
authors.affiliation: University de Bordeaux, Institut des Maladies Neurodégénératives, UMR 5293 Bordeaux, France; CNRS, Institut des Maladiesw Neurodégénératives, UMR 5293 Bordeaux, France.
authors.forename: Gregory
authors.initials: G
authors.lastname: Porras
authors.forename: Qin
authors.initials: Q
authors.lastname: Li
authors.forename: Erwan
authors.initials: E
authors.lastname: Bezard
mesh_terms: D000818:Animals; D016663:Cercopithecinae; D021081:Chronobiology Disorders / Q000503:physiopathology; D003072:Cognition Disorders; D004195:Disease Models, Animal; D018450:Disease Progression; D000882:Haplorhini; D016631:Lewy Bodies / Q000473:pathology; D020267:MPTP Poisoning / Q000473:pathology / Q000503:physiopathology; D009068:Movement / Q000502:physiology; D010300:Parkinson Disease / Q000473:pathology / Q000503:physiopathology; D012893:Sleep Wake Disorders / Q000503:physiopathology; D057170:Translational Research, Biomedical