title: Agranulocytosis during treatment of chronic hepatitis C complicated by hyperthyreosis. Case reports.
abstract: Agranulocytosis is a life-threatening disorder characterised by a greatly decreased number of circulating neutrophils below 500/μL. This  article presents two cases of agranulocytosis in patients treated with pegylated interferon and ribavirin due to chronic hepatitis C. Interferon  induced hyperthyroidism, which required the use of a tyreostatic. Anti-thyroid drugs (ATD) used to treat hyperthyroidism can cause agranulocytosis. The synergistic reaction of ATD and interferon on bone marrow cannot be excluded.
authors.affiliation: Department of Infectious Diseases and Hepatology, L. Rydygier Collegium Medicum in Bydgoszcz, ul. Św. Floriana 12, Bydgoszcz, Poland. d.kozielewicz@wsoz.pl
authors.forename: Dorota
authors.initials: D
authors.lastname: Kozielewicz
authors.forename: Kornelia
authors.initials: K
authors.lastname: Karwowska
authors.forename: Dorota
authors.initials: D
authors.lastname: Dybowska
authors.forename: Waldemar
authors.initials: W
authors.lastname: Halota
mesh_terms: D000328:Adult; D000380:Agranulocytosis / Q000139:chemically induced*; D013956:Antithyroid Agents / Q000009:adverse effects*; D000998:Antiviral Agents / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D005260:Female; D019698:Hepatitis C, Chronic / Q000188:drug therapy*; D006801:Humans; D006980:Hyperthyroidism / Q000139:chemically induced* / Q000188:drug therapy; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000009:adverse effects; D008713:Methimazole / Q000009:adverse effects; D008875:Middle Aged; D011092:Polyethylene Glycols / Q000009:adverse effects; D011441:Propylthiouracil / Q000009:adverse effects; D011994:Recombinant Proteins / Q000009:adverse effects; D012254:Ribavirin / Q000009:adverse effects; D013997:Time Factors; D019562:Viral Load
chemical_list: D013956:Antithyroid Agents; D000998:Antiviral Agents; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; D012254:Ribavirin; D008713:Methimazole; D011441:Propylthiouracil; C417083:peginterferon alfa-2b; C100416:peginterferon alfa-2a