title: Development and evaluation of tetrapod-shaped granular artificial bones.
abstract: We have developed a novel form of granular artificial bone "Tetrabones" with a homogeneous tetrapod shape and uniform size. Tetrabones are four armed structures that accumulate to form the intergranular pores that allow invasion of cells and blood vessels. In this study we evaluated the physicochemical characteristics of Tetrabones in vitro, and compared their biological and biomechanical properties in vivo to those of conventional β-tricalcium phosphate (β-TCP) granule artificial bone. Both the rupture strength and elastic modulus of Tetrabone particles were higher than those of β-TCP granules in vitro. The connectivity of intergranular pores 100, 300, and 400 μm in size were higher in Tetrabones than in the β-TCP granules. Tetrabones showed similar osteoconductivity and biomechanical stiffness to β-TCP at 2 months after implantation in an in vivo study of canine bone defects. These results suggest that Tetrabones may be a good bone graft material in bone reconstruction.
authors.affiliation: Center for Disease Biology and Integrative Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. tjdwls1101@hotmail.com
authors.forename: Sungjin
authors.initials: S
authors.lastname: Choi
authors.forename: I-li
authors.initials: IL
authors.lastname: Liu
authors.forename: Kenichi
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Kazuyo
authors.initials: K
authors.lastname: Igawa
authors.forename: Manabu
authors.initials: M
authors.lastname: Mochizuki
authors.forename: Takamasa
authors.initials: T
authors.lastname: Sakai
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Echigo
authors.forename: Muneki
authors.initials: M
authors.lastname: Honnami
authors.forename: Shigeki
authors.initials: S
authors.lastname: Suzuki
authors.forename: Ung-il
authors.initials: UI
authors.lastname: Chung
authors.forename: Nobuo
authors.initials: N
authors.lastname: Sasaki
mesh_terms: D016475:3T3 Cells; D000818:Animals; D001672:Biocompatible Materials; D001696:Biomechanical Phenomena; D001842:Bone and Bones; D002130:Calcium Phosphates / Q000737:chemistry; D004285:Dogs; D051379:Mice; D008855:Microscopy, Electron, Scanning; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D002130:Calcium Phosphates; C485817:beta-tricalcium phosphate