title: The conjugated auxin indole-3-acetic acid-aspartic acid promotes plant disease development.
abstract: Auxin is a pivotal plant hormone that regulates many aspects of plant growth and development. Auxin signaling is also known to promote plant disease caused by plant pathogens. However, the mechanism by which this hormone confers susceptibility to pathogens is not well understood. Here, we present evidence that fungal and bacterial plant pathogens hijack the host auxin metabolism in Arabidopsis thaliana, leading to the accumulation of a conjugated form of the hormone, indole-3-acetic acid (IAA)-Asp, to promote disease development. We also show that IAA-Asp increases pathogen progression in the plant by regulating the transcription of virulence genes. These data highlight a novel mechanism to promote plant susceptibility to pathogens through auxin conjugation.
authors.affiliation: Centre de Recherche en Amélioration Végétale, Département de Biologie, Université de Sherbrooke, Sherbrooke, Quebec J1K2R1, Canada.
authors.forename: Rocío
authors.initials: R
authors.lastname: González-Lamothe
authors.forename: Mohamed
authors.initials: M
authors.lastname: El Oirdi
authors.forename: Normand
authors.initials: N
authors.lastname: Brisson
authors.forename: Kamal
authors.initials: K
authors.lastname: Bouarab
mesh_terms: D017360:Arabidopsis / Q000235:genetics / Q000378:metabolism / Q000382:microbiology*; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism; D001224:Aspartic Acid / Q000378:metabolism* / Q000494:pharmacology; D020171:Botrytis / Q000472:pathogenicity; D003517:Cyclopentanes / Q000378:metabolism; D018506:Gene Expression Regulation, Plant; D054884:Host-Pathogen Interactions; D007210:Indoleacetic Acids / Q000378:metabolism* / Q000494:pharmacology; D007211:Indoles / Q000378:metabolism; D054883:Oxylipins / Q000378:metabolism; D010935:Plant Diseases / Q000382:microbiology*; D010937:Plant Growth Regulators / Q000378:metabolism / Q000494:pharmacology; D044224:Pseudomonas syringae / Q000472:pathogenicity; D020156:Salicylic Acid / Q000378:metabolism; D015398:Signal Transduction; D013844:Thiazoles / Q000378:metabolism; D014774:Virulence; D000094162:Phytoalexins
chemical_list: D029681:Arabidopsis Proteins; D001224:Aspartic Acid; D003517:Cyclopentanes; D007210:Indoleacetic Acids; D007211:Indoles; D054883:Oxylipins; D010937:Plant Growth Regulators; D020156:Salicylic Acid; D013844:Thiazoles; C102405:camalexin; D000094162:Phytoalexins; C011006:jasmonic acid; C030737:indoleacetic acid