title: Breast manifestations of systemic diseases.
abstract: Although much emphasis has been placed on the primary presentations of breast cancer, little focus has been placed on how systemic illnesses may affect the breast. In this article, we discuss systemic illnesses that can manifest in the breast. We summarize the clinical features, imaging, histopathology, and treatment recommendations for endocrine, vascular, systemic inflammatory, infectious, and hematologic diseases, as well as for the extramammary malignancies that can present in the breast. Despite the rarity of these manifestations of systemic disease, knowledge of these conditions is critical to the appropriate evaluation and treatment of patients presenting with breast symptoms.
authors.affiliation: Division of General Internal Medicine, Mayo Clinic, Rochester, MN, USA.
authors.forename: Christina A
authors.initials: CA
authors.lastname: Dilaveri
authors.forename: Maire Brid
authors.initials: MB
authors.lastname: Mac Bride
authors.forename: Nicole P
authors.initials: NP
authors.lastname: Sandhu
authors.forename: Lonzetta
authors.initials: L
authors.lastname: Neal
authors.forename: Karthik
authors.initials: K
authors.lastname: Ghosh
authors.forename: Dietlind L
authors.initials: DL
authors.lastname: Wahner-Roedler