title: ABO blood type, diabetes and risk of gastrointestinal cancer in northern China.
abstract: OBJECTIVE
  To explore the potential risk factors related to gastrointestinal cancer in northern China.
  
  
  METHODS
  A total of 3314 cases of gastrointestinal cancer (esophageal, gastric, pancreatic and biliary) and 2223 controls (including healthy individuals, glioma and thyroid cancer) were analyzed by case-control study. Multivariable logistic regression analysis was applied to evaluate the association between different cancers and hepatitis B surface antigen, sex, age, blood type, diabetes, or family history of cancer.
  
  
  RESULTS
  Type 2 diabetes was significantly associated with gastric, biliary and pancreatic cancer with an OR of 2.0-3.0. Blood type B was significantly associated with esophageal cancer [odd ratio (OR) = 1.53, 95% confidence interval (CI) = 1.10-2.14] and biliary cancer (OR = 1.49, 95% CI = 1.09-2.05). The prevalence of type 2 diabetes was significantly higher in gastric, biliary and pancreatic cancers compared with other groups, with ORs ranging between 2.0 and 3.0. Family history of cancer was strongly associated with gastrointestinal compared with other cancers.
  
  
  CONCLUSIONS
  Blood type B individuals are susceptible to esophageal and biliary cancer. Type 2 diabetes is significantly associated with gastric, biliary and especially pancreatic cancer.
authors.affiliation: Department of Gastroenterology and Hepatology, Chinese PLA General Hospital, Beijing 100853, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Gong
authors.forename: Yun-Sheng
authors.initials: YS
authors.lastname: Yang
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Zhang
authors.forename: Ming
authors.initials: M
authors.lastname: Su
authors.forename: Jean
authors.initials: J
authors.lastname: Wang
authors.forename: Jin-Dong
authors.initials: JD
authors.lastname: Han
authors.forename: Ming-Zhou
authors.initials: MZ
authors.lastname: Guo
mesh_terms: D000017:ABO Blood-Group System; D000328:Adult; D000368:Aged; D001788:Blood Grouping and Crossmatching; D016022:Case-Control Studies; D002681:China; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D004198:Disease Susceptibility; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000097:blood* / Q000209:etiology* / Q000473:pathology; D006514:Hepatitis B Surface Antigens; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D000017:ABO Blood-Group System; D006514:Hepatitis B Surface Antigens