title: Anatomically dependent anticonvulsant properties of temporally-coded electrical stimulation.
abstract: In the PTZ animal model of epilepsy, electrical stimulation applied to the amygdaloid complex may result in either pro-convulsive or anticonvulsant effect, depending on the temporal pattern used (i.e. periodic-PS and non-periodic-NPS electrical stimulation). Our hypothesis is that the anatomical target is a determinant factor for the differential effect of temporally-coded patterns on seizure outcome. The threshold dose of PTZ to elicit forelimb clonus and generalized tonic-clonic seizure behavior was measured. The effect of amygdaloid complex PS on forelimb clonus threshold showed a pro-convulsive effect while NPS was anticonvulsant. NPS also significantly increased generalized tonic-clonic threshold; while PS, although at lower threshold levels, did not present statistical significance. Thalamus stimulation did not affect forelimb clonus threshold and showed similar anticonvulsant profiles for both PS and NPS on generalized tonic-clonic threshold. In summary, the anatomical target is a determinant factor on whether temporally-coded ES differentially modulates seizure outcome.
authors.affiliation: Núcleo de Neurociências, Departamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Minas Gerais, Brazil.
authors.forename: Daniel de Castro
authors.initials: Dde C
authors.lastname: Medeiros
authors.forename: Vinícius Rosa
authors.initials: VR
authors.lastname: Cota
authors.forename: Maura Regina Silva da Páscoa
authors.initials: MR
authors.lastname: Vilela
authors.forename: Flávio Afonso Gonçalves
authors.initials: FA
authors.lastname: Mourão
authors.forename: André Ricardo
authors.initials: AR
authors.lastname: Massensini
authors.forename: Márcio Flávio Dutra
authors.initials: MF
authors.lastname: Moraes
mesh_terms: D000679:Amygdala / Q000502:physiology*; D000818:Animals; D004195:Disease Models, Animal; D004599:Electric Stimulation Therapy / Q000379:methods*; D004829:Epilepsy, Generalized / Q000139:chemically induced / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D010433:Pentylenetetrazole / Q000627:therapeutic use* / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D013788:Thalamus / Q000502:physiology
chemical_list: D010433:Pentylenetetrazole