title: [Dyslipidemia: news in diagnosis and drug therapy].
abstract: Plasma lipid levels are to a large extent determined by genetic factors. In its more extreme forms this is manifested as familial hyperlipidemias, which are an important cause of premature coronary heart disease. It has been demonstrated that rigorous treatment of familial forms reduces the burden of ischemic heart disease. Statins are among the most studied drugs in cardiovascular prevention; a number of large-scale clinical trials have demonstrated that statins substantially reduce cardiovascular morbidity and mortality in both primary and secondary prevention. The currently available evidence suggests that the clinical benefit is largely independent of the type of statin, but depends on the extent of LDL-C lowering. When the most potent statins are insufficient, LDL-C apheresis should be used.
authors.affiliation: Servizio di Diabetologia e Malattie Metaboliche, Azienda Ospedaliero-Universitaria, Trieste, Italy. cattin_units.it
authors.forename: Luigi
authors.initials: L
authors.lastname: Cattin
authors.forename: Franco
authors.initials: F
authors.lastname: Spangano
authors.forename: Maurizio
authors.initials: M
authors.lastname: Fonda
mesh_terms: D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D000069059:Atorvastatin; D015415:Biomarkers / Q000097:blood; D001781:Blood Component Removal / Q000379:methods; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D002986:Clinical Trials as Topic; D050171:Dyslipidemias / Q000097:blood / Q000175:diagnosis* / Q000178:diet therapy / Q000188:drug therapy* / Q000628:therapy; D006538:Heptanoic Acids / Q000627:therapeutic use*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D006950:Hyperlipidemia, Familial Combined / Q000175:diagnosis / Q000188:drug therapy; D017202:Myocardial Ischemia / Q000517:prevention & control*; D011758:Pyrroles / Q000627:therapeutic use*; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood
chemical_list: D000924:Anticholesteremic Agents; D015415:Biomarkers; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D006538:Heptanoic Acids; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011758:Pyrroles; D014280:Triglycerides; D000069059:Atorvastatin