title: Increase in mean platelet volume in patients with myocardial bridge.
abstract: OBJECTIVE
  Myocardial bridge is associated with atherosclerosis altered in shear stress and endothelial dysfunction. Mean platelet volume (MPV), a determinant of platelet activation, is shown to be related with atherosclerosis and endothelial dysfunction. In this study, we aimed to evaluate platelet function assessed by MPV in patients with myocardial bridge.
  
  
  METHODS
  Forty-two patients with myocardial bridge in the left anterior descending artery (LAD) and 43 age- and gender-matched healthy participants were included in the study. Myocardial bridging was defined as an intramyocardial systolic compression or milking of a segment of an epicardial coronary artery on angiography. For the entire study population, MPV was measured using an automatic blood counter.
  
  
  RESULTS
  The study population consisted of 42 patients with myocardial bridge (52.7 ± 10.2, 76.2% male) and 43 age- and sex-matched healthy control participants (52.1 ± 10.4, 74.4% male). Compared to the control group, MPV value was significantly higher in patients with myocardial bridge (8.9 ± 1.24 vs 8.3 ± 0.78; P = .01). Further, there were no significant differences between groups regarding hemoglobin level, platelet count, fasting blood glucose, and creatinine levels.
  
  
  CONCLUSIONS
  Our study findings indicated that myocardial bridge is associated with elevated MPV values. Our results might partly explain the increased cardiovascular events in patients with myocardial bridge.
authors.affiliation: Ankara Ataturk Education and Research Hospital, Ankara, Turkey.
authors.forename: Emine
authors.initials: E
authors.lastname: Bilen
authors.forename: Ibrahim Halil
authors.initials: IH
authors.lastname: Tanboga
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kurt
authors.forename: Umran
authors.initials: U
authors.lastname: Kocak
authors.forename: Huseyin
authors.initials: H
authors.lastname: Ayhan
authors.forename: Telat
authors.initials: T
authors.lastname: Keles
authors.forename: Engin
authors.initials: E
authors.lastname: Bozkurt
mesh_terms: D050197:Atherosclerosis / Q000097:blood / Q000209:etiology / Q000473:pathology; D001792:Blood Platelets / Q000473:pathology*; D016022:Case-Control Studies; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D063847:Mean Platelet Volume / Q000379:methods; D008875:Middle Aged; D054084:Myocardial Bridging / Q000097:blood* / Q000209:etiology / Q000473:pathology