title: Difference in glucose intolerance between C57BL/6J and ICR strain mice with streptozotocin/nicotinamide-induced diabetes.
abstract: Blood glucose and plasma insulin levels between C57BL/6J and ICR strain mice with nicotinamide (NA) and streptozotocin (STZ)-induced diabetes were compared to establish a suitable strain of the experimental diabetic mouse model. The mice were intraperitoneally treated twice with STZ (100 mg/kg) 15 min after injection of NA (120 mg/kg) at a 1-day interval, and non-fasting blood glucose level was then weekly monitored for 5 weeks. The blood glucose level in ICR mice gradually increased and was about 2-times higher than that in C57BL/6J mice at the end of the observation. The plasma insulin level in ICR mice was comparatively low, compared with that in C57BL/6J mice. ICR mice were also markedly glucose-intolerant when oral glucose tolerance test was performed. These results indicate that ICR strain is more sensitive than C57BL/6J strain as a mouse model with NA/STZ-induced mild diabetes.
authors.affiliation: Laboratory of Environmental Chemistry, Faculty of Pharmaceutical Sciences, Hiroshima International University, 5-1-1 Hirokoshingai, Kure, Hiroshima 737-0112, Japan.
authors.forename: Ryo
authors.initials: R
authors.lastname: Shimizu
authors.forename: Fumitoshi
authors.initials: F
authors.lastname: Sakazaki
authors.forename: Tomofumi
authors.initials: T
authors.lastname: Okuno
authors.forename: Katsuhiko
authors.initials: K
authors.lastname: Nakamuro
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ueno
mesh_terms: D000818:Animals; D001786:Blood Glucose; D003921:Diabetes Mellitus, Experimental / Q000097:blood*; D004195:Disease Models, Animal; D018149:Glucose Intolerance / Q000097:blood*; D005951:Glucose Tolerance Test; D007328:Insulin / Q000097:blood; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008813:Mice, Inbred ICR; D009536:Niacinamide
chemical_list: D001786:Blood Glucose; D007328:Insulin; D009536:Niacinamide