title: [Impairments of conditioned behavior in adult rats induced by interleukine-1beta treatment in early postnatal ontogenesis].
abstract: Impairments of cognitive functions in children and adolescents are often consequences ofperinatal pathology (natal injuries, ischemia, hypoxia, infection and allergic diseases), which are accompanied by enhanced production ofproinflammatory cytokine interleukine-1beta. In this work it was shown that treatment with interleukine-1beta during the third week of life impaired active and passive avoidance conditioning in adult rats at the age of 60-70 days.
authors.forename: O E
authors.initials: OE
authors.lastname: Zubareva
authors.forename: K P
authors.initials: KP
authors.lastname: Shcherbakova
authors.forename: S V
authors.initials: SV
authors.lastname: Kalemenev
authors.forename: A S
authors.initials: AS
authors.lastname: Simbirtsev
authors.forename: V M
authors.initials: VM
authors.lastname: Klimenko
mesh_terms: D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects*; D003213:Conditioning, Psychological / Q000187:drug effects*; D048788:Growth and Development / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects; D006801:Humans; D053583:Interleukin-1beta / Q000494:pharmacology*; D008297:Male; D057567:Memory, Long-Term / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D053583:Interleukin-1beta