title: Uric acid is an important predictor for hypertensive early atherosclerosis.
abstract: BACKGROUND
  The association between hyperuricemia and cardiovascular disease in hypertensive subjects is controversial. Attempts to elucidate the possible association between hyperuricemia and early atherosclerosis in hypertensive patients may provide alternative prevention or therapy targets for future cardiovascular events.
  
  
  METHODS
  A total of 67 hypertensive and 30 healthy subjects underwent B-mode ultrasonography to measure carotid intima media thickness (C-IMT). All biochemical analyses were assessed by local laboratories using standard laboratory methods.
  
  
  RESULTS
  C-IMT, serum uric acid (UA) levels, and mean arterial blood pressure (MBP) levels were significantly higher in hypertensive population compared to healthy subjects (P<0.001). Among hypertensive subjects, high sensitivity C-reactive protein (hs-CRP), C-IMT, and proteinuria levels were significantly higher in hyperuricemic patients compared to normouricemic participants (for all, P<0.05). Age (r=0.28, P=0.02), MBP (r=0.34, P=0.04), hs-CRP (r=0.58, P=0.006), proteinuria (r=0.58, P=0.007), estimated glomerular filtration rate (r=-0.35, P=0.02), and UA (r=0.31, P=0.02) levels were significantly associated with C-IMT levels. Multiple linear regression analysis using C-IMT as a dependent variable showed that age (beta=0.84, P=0.03) and UA levels (beta=-0.87, P=0.02) were independently associated with C-IMT.
  
  
  CONCLUSIONS
  Hyperuricemia is an independent predictor for early atherosclerosis in hypertensive subjects with normal renal function. Therefore, the optimal control of UA may provide further benefits in preventing atherosclerosis and hypertensive end-organ injury.
authors.affiliation: Department of Nephrology, Sirnak Hospital, Bahcelievler, Sirnak, Turkey.
authors.forename: Ruya
authors.initials: R
authors.lastname: Mutluay
authors.forename: Serpil Muge
authors.initials: SM
authors.lastname: Deger
authors.forename: Eylem
authors.initials: E
authors.lastname: Bahadir
authors.forename: Alim Ozgur
authors.initials: AO
authors.lastname: Durmaz
authors.forename: Riza
authors.initials: R
authors.lastname: Citil
authors.forename: Sukru
authors.initials: S
authors.lastname: Sindel
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000097:blood* / Q000000981:diagnostic imaging*; D015415:Biomarkers; D002097:C-Reactive Protein / Q000032:analysis; D002339:Carotid Arteries / Q000000981:diagnostic imaging*; D059168:Carotid Intima-Media Thickness; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D033461:Hyperuricemia / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011507:Proteinuria / Q000150:complications; D012307:Risk Factors; D014527:Uric Acid / Q000097:blood*
chemical_list: D015415:Biomarkers; D014527:Uric Acid; D002097:C-Reactive Protein