title: Comparing anti-hyperglycemic activity and acute oral toxicity of three different trivalent chromium complexes in mice.
abstract: Three different ligands (rutin, folate and stachyose) of chromium(III) complexes were compared to examine whether they have similar effect on anti-hyperglycemic activity as well as the acute toxicity status. Anti-hyperglycemic activities of chromium rutin complex (CrRC), chromium folate complex (CrFC) and chromium stachyose complex (CrSC) were examined in alloxan-induced diabetic mice with daily oral gavage for a period of 2 weeks at the dose of 0.5-3.0 mg Cr/kg. Acute toxicities of CrRC and CrFC were tested using ICR mice at the dose of 1.0-5.0 g/kg with a single oral gavage and observed for a period of 2 weeks. Biological activities results indicated that only CrRC and CrFC could decrease blood glucose level, reduce the activities of aspartate transaminase, alanine transaminase, alkaline phosphatase, and increase liver glycogen level. In acute toxicity study, LD(50) values for both CrRC and CrFC were above 5.0 g/kg. The minimum lethal dose for CrFC was above 5.0 g/kg, while that for CrRC was 1.0 g/kg. Anti-diabetic activity of those chromium complexes was not similar and their acute toxicities were also different. CrFC represent an optimal chromium supplement among those chromium complexes with potential therapeutic value to control blood glucose in diabetes and non-toxicity in acute toxicity.
authors.affiliation: School of Food and Biological Engineering, Jiangsu University, 301 Xuefu Rd., 212013 Zhenjiang, Jiangsu, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Li
authors.forename: Xiangyang
authors.initials: X
authors.lastname: Wu
authors.forename: Yanmin
authors.initials: Y
authors.lastname: Zou
authors.forename: Ting
authors.initials: T
authors.lastname: Zhao
authors.forename: Min
authors.initials: M
authors.lastname: Zhang
authors.forename: Weiwei
authors.initials: W
authors.lastname: Feng
authors.forename: Liuqing
authors.initials: L
authors.lastname: Yang
mesh_terms: D000284:Administration, Oral; D000496:Alloxan; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight / Q000187:drug effects; D002857:Chromium / Q000008:administration & dosage / Q000494:pharmacology* / Q000633:toxicity; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D007004:Hypoglycemic Agents / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D023382:Toxicity Tests, Acute
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D002857:Chromium; D000496:Alloxan