title: Evaluation of the biocompatibility of a coating material for an implantable bladder volume sensor.
abstract: As the applications for implantable medical devices have increased, the need for biocompatible packaging materials has become important. Recently, we reported an implantable sensor for real-time monitoring of the changes in bladder volume, which necessitated finding a safe coating material for use in bladder tissue. At present, materials like polyethylene glycol (PEG), polydimethylsiloxane (PDMS) and parylene-C are used in biomedical devices or as coating materials, owing to their excellent safety in various medical fields. However, few studies have assessed their safety in bladder tissue, therefore, we evaluated the biocompatibility of PEG, PDMS and parylene-C in the bladder. All three materials turned out to be safe in in vitro tests of live/dead staining and cell viability. In vivo tests with hematoxylin and eosin and immunofluorescence staining with MAC387 showed no persistent inflammation. Therefore, we consider that the three materials are biocompatible in bladder tissue. Despite this safety, however, PEG has biodegradable characteristics and thus is not suitable for use as packaging. We suggest that PDMS and parylene-C can be used as safe coating materials for the implantable bladder volume sensor reported previously.
authors.affiliation: Department of Urology, Seoul St. Mary's Hospital, The Catholic University of Korea, South Korea.
authors.forename: Su-Jin
authors.initials: SJ
authors.lastname: Kim
authors.forename: Dong-Sup
authors.initials: DS
authors.lastname: Lee
authors.forename: In-Gul
authors.initials: IG
authors.lastname: Kim
authors.forename: Dong-Wan
authors.initials: DW
authors.lastname: Sohn
authors.forename: Jung-Yul
authors.initials: JY
authors.lastname: Park
authors.forename: Bum-Kyoo
authors.initials: BK
authors.lastname: Choi
authors.forename: Sae-Woong
authors.initials: SW
authors.lastname: Kim
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000009:adverse effects / Q000737:chemistry*; D015374:Biosensing Techniques / Q000379:methods*; D002470:Cell Survival / Q000187:drug effects; D004129:Dimethylpolysiloxanes / Q000737:chemistry; D008297:Male; D051379:Mice; D041681:NIH 3T3 Cells; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D019736:Prostheses and Implants; D011817:Rabbits; D001743:Urinary Bladder; D014992:Xylenes / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D004129:Dimethylpolysiloxanes; D011108:Polymers; D014992:Xylenes; C011055:parylene; D011092:Polyethylene Glycols; C013830:baysilon