title: The response of human dendritic cells to co-ligation of pattern-recognition receptors.
abstract: Dendritic cells (DCs) are key antigen-presenting cells that express a wide variety of pattern-recognition receptors (PRRs). Triggering of a single PRR, especially Toll-like receptors (TLRs) and C-type lectins, induces maturation of DCs, but cooperativity between multiple PRRs is needed in order to achieve an effective immune response. In this review, we summarize the published data related to the effect of individual and joint PRR agonists on DCs and Langerhans-like cells derived from monocytes (MoDCs and MoLCs, respectively). Our results demonstrate that MoDCs co-stimulated with TLR3/TLR7 and TLR3/Dectin-1 ligands induced superior T helper (Th)1 and Th17 immune responses, compared to effects of single agonists. The opposite outcome was observed after co-ligation of TLR3 and Langerin on MoLCs. These findings may be relevant to improve strategy for tumor immunotherapy.
authors.affiliation: Medical Faculty of the Military Medical Academy, University of Defense in Belgrade, Crnotravska 17, 11002 Belgrade, Serbia.
authors.forename: Tanja
authors.initials: T
authors.lastname: Dzopalic
authors.forename: Ivan
authors.initials: I
authors.lastname: Rajkovic
authors.forename: Ana
authors.initials: A
authors.lastname: Dragicevic
authors.forename: Miodrag
authors.initials: M
authors.lastname: Colic
mesh_terms: D015703:Antigens, CD / Q000378:metabolism; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D007801:Langerhans Cells / Q000276:immunology; D037181:Lectins, C-Type / Q000378:metabolism*; D037241:Mannose-Binding Lectins / Q000378:metabolism; D009000:Monocytes / Q000276:immunology / Q000378:metabolism; D009369:Neoplasms / Q000628:therapy; D051192:Receptors, Pattern Recognition / Q000378:metabolism*; D018417:Th1 Cells / Q000276:immunology; D058504:Th17 Cells / Q000276:immunology; D051193:Toll-Like Receptors / Q000378:metabolism*; D000099181:Dectin-1
chemical_list: D015703:Antigens, CD; D037181:Lectins, C-Type; D037241:Mannose-Binding Lectins; D051192:Receptors, Pattern Recognition; D051193:Toll-Like Receptors; C121916:CD207 protein, human; C546929:CLEC7A protein, human; D000099181:Dectin-1