title: Meta-analysis of randomized controlled trials comparing lightweight and heavyweight mesh for Lichtenstein inguinal hernia repair.
abstract: OBJECTIVE
  Lichtenstein inguinal hernia repair is associated with a low incidence of recurrence; however, the use of heavyweight mesh has been linked with chronic pain and foreign body sensation. It is hypothesized that the use of lightweight mesh may reduce these problems. This study aims to use meta-analysis to compare lightweight and heavyweight mesh for Lichtenstein inguinal hernia repair.
  
  
  METHODS
  Information was gathered from randomized controlled trials that compared lightweight and heavyweight mesh for Lichtenstein inguinal hernia repair. The Cochrane Library, Medline, EMBASE, trial registries, conference proceedings and reference lists were searched. Primary outcome measures were chronic pain, foreign body sensation and hernia recurrence. Secondary outcome measures were duration of surgery, mean visual analogue scale (VAS) pain scores, surgical-site infection, testicular atrophy and haematoma/seroma. The pooled Peto odds ratio (OR) was calculated for categorical data and weighted mean difference (WMD) for continuous data.
  
  
  RESULTS
  Six trials with 1936 hernias were included. Lightweight mesh was associated with reduced chronic pain (OR = 0.67, 95% CI = 0.50-0.90; p < 0.01) and foreign body sensation (OR = 0.43, 95% CI = 0.21-0.93; p < 0.05). Lightweight mesh was also associated with lower VAS pain scores at 3 months after surgery (WMD = -0.35, 95% CI = -0.39 to -0.31; p < 0.0001). There were no differences in hernia recurrence (OR = 1.19, 95% CI = 0.54-2.64; p = 0.66) or other post-operative complications between the two groups.
  
  
  CONCLUSIONS
  The use of lightweight mesh in Lichtenstein inguinal hernia repair is associated with less chronic pain, and foreign body sensation compared with heavyweight mesh without any difference in recurrence.
authors.affiliation: Barts and The London NHS Trust, Queen Mary's University, West Smithfield, London EC1A 7BE, UK. mohsinuzzaman@yahoo.co.uk
authors.forename: M M
authors.initials: MM
authors.lastname: Uzzaman
authors.forename: K
authors.initials: K
authors.lastname: Ratnasingham
authors.forename: N
authors.initials: N
authors.lastname: Ashraf
mesh_terms: D001284:Atrophy / Q000209:etiology; D059350:Chronic Pain / Q000209:etiology; D005547:Foreign Bodies / Q000150:complications; D006552:Hernia, Inguinal / Q000601:surgery*; D059685:Herniorrhaphy / Q000009:adverse effects; D006801:Humans; D008297:Male; D010149:Postoperative Pain / Q000209:etiology; D016032:Randomized Controlled Trials as Topic; D012008:Recurrence; D012677:Sensation; D049291:Seroma / Q000209:etiology; D013526:Surgical Mesh / Q000009:adverse effects; D013530:Surgical Wound Infection / Q000209:etiology; D013737:Testis / Q000473:pathology*