title: [Stem cell-based treatment of neurologic diseases].
abstract: Therapeutic strategies based on stem cells are being increasingly used to treat a wide range of neurological diseases. Although these strategies were initially designed to replace dead cells in injured tissue, the potential of stem cells to migrate, secrete trophic factors, and immunomodulate allows their therapeutic use as a vehicle for gene therapy, as in Parkinson's disease, or as immunomodulators and neuroprotectors in diseases such as multiple sclerosis. This review will focus on current clinical and experimental evidence on the treatment of neurological disorders with strategies based on stem cells.
authors.affiliation: Unitat de Neuroimmunologia Clinica, Centre d'Esclerosi Múltiple de Catalunya (CEM-Cat), Vall d'Hebron Institut de Recerca, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain. carme.costa@vhir.org
authors.forename: Carme
authors.initials: C
authors.lastname: Costa
authors.forename: Manuel
authors.initials: M
authors.lastname: Comabella
authors.forename: Xavier
authors.initials: X
authors.lastname: Montalban
mesh_terms: D000544:Alzheimer Disease / Q000628:therapy; D006801:Humans; D006816:Huntington Disease / Q000628:therapy; D009103:Multiple Sclerosis / Q000628:therapy; D009422:Nervous System Diseases / Q000628:therapy*; D009423:Nervous System Neoplasms / Q000628:therapy; D019636:Neurodegenerative Diseases / Q000628:therapy; D010300:Parkinson Disease / Q000628:therapy; D033581:Stem Cell Transplantation / Q000379:methods*; D020521:Stroke / Q000628:therapy