title: Clinicopathological feature of extrahepatic cholangiocarcinoma without jaundice: a single-center experience.
abstract: OBJECTIVE
  The prognosis remains unsatisfactory even if the patient undergoes extensive surgery, which is the only curative treatment for these tumors. Therefore, early detection and diagnosis are needed to improve long-term survival. To investigate the clinicopathological feature of extrahepatic cholangiocarcinoma in patients presenting without jaundice compared with the features of tumors in patients presenting with jaundice.
  
  
  METHODS
  This was a retrospective study of 50 patients resected for extrahepatic cholangiocarcinoma. There were 15 non-jaundiced (Group A) and 35 jaundiced patients (Group B). Data on demographic and clinical features, surgical procedures and pathological diagnoses were collected retrospectively.
  
  
  RESULTS
  Preoperative mean serum levels of total bilirubin, aspartate aminotransferase, alanine aminotransaminase, alkaline phosphatase and gamma-glutamyltranspeptidase were statistically different between the groups. There was also a significant difference in the location of tumors. The distal tumors occurred in 9 non-jaundiced and 31 jaundiced patients (p=0.048). There were no significant differences between the characteristics and preoperative laboratory data of the patients with perihilar tumors and those with distal tumors.
  
  
  CONCLUSIONS
  We believe that finding the disease in asymptomatic and non-jaundiced patients is very important for their prognosis. Further studies are needed and efforts should also continue to identify patients with suspicious findings.
authors.affiliation: Department of Surgery, Saiseikai Yokohamashi Tobu Hospital, Kanagawa, Japan. yasuito@ca3.so-net.ne.jp
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Ito
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kenmochi
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Irino
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Egawa
authors.forename: Shinobu
authors.initials: S
authors.lastname: Hayashi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nagashima
authors.forename: Yuko
authors.initials: Y
authors.lastname: Kitagawa
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D058070:Asymptomatic Diseases; D001650:Bile Duct Neoplasms / Q000097:blood / Q000150:complications / Q000473:pathology* / Q000601:surgery; D017734:Bile Ducts, Extrahepatic / Q000473:pathology* / Q000601:surgery; D001662:Biliary Tract Surgical Procedures; D014408:Biomarkers, Tumor / Q000097:blood; D016009:Chi-Square Distribution; D018281:Cholangiocarcinoma / Q000097:blood / Q000150:complications / Q000473:pathology* / Q000601:surgery; D055088:Early Detection of Cancer; D005260:Female; D006498:Hepatectomy; D006801:Humans; D007564:Japan; D007565:Jaundice / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D016577:Pancreaticoduodenectomy; D011237:Predictive Value of Tests; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D014408:Biomarkers, Tumor