title: [Study on the preparation of curcumin inclusion complex and its stability].
abstract: OBJECTIVE
  To prepare the curcumin inclusion complex and study its stability.
  
  
  METHODS
  Beta-cyclodextrin (beta-CD) was chosen as inclusion material and orthogonal design method was used. UV-Vis spectrophotometer was used to determine the solubility and content of different samples. They were placed under conditions of light and the solution containing Fe(3+) to determine their stability.
  
  
  RESULTS
  The optimum preparation procedure were : curcumin and beta-cyclodextrin feed molar ratio of 1: 1, the concentration of ethanol was 40%, 40 degrees C inclusion temperature and 1 h reaction time.
  
  
  CONCLUSIONS
  Inclusion complex prepared under eptimal condition is stable.
authors.affiliation: College of Chemistry and Chemical Engineering, Linyi University, Linyi 276005, China. gaozhenshen@lyu.edu.cn
authors.forename: Zhen-Shen
authors.initials: ZS
authors.lastname: Gao
authors.forename: Ying-Xiao
authors.initials: YX
authors.lastname: Fu
authors.forename: Jian-Duo
authors.initials: JD
authors.lastname: Wang
mesh_terms: D030024:Curcuma / Q000737:chemistry*; D003474:Curcumin / Q000008:administration & dosage / Q000737:chemistry*; D004337:Drug Carriers; D004339:Drug Compounding; D004355:Drug Stability; D000431:Ethanol / Q000737:chemistry; D027343:Rhizome / Q000737:chemistry; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D013678:Technology, Pharmaceutical / Q000379:methods*; D013696:Temperature; D013997:Time Factors; D047392:beta-Cyclodextrins / Q000008:administration & dosage / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D047392:beta-Cyclodextrins; D000431:Ethanol; D003474:Curcumin