title: Dual-modality photothermal optical coherence tomography and magnetic-resonance imaging of carbon nanotubes.
abstract: We demonstrate polyethylene-glycol-coated single-walled carbon nanotubes (CNTs) as contrast agents for both photothermal optical coherence tomography (OCT) and magnetic-resonance imaging (MRI). Photothermal OCT was accomplished with a spectral domain OCT system with an amplitude-modulated 750 nm pump beam using 10 mW of power, and T(2) MRI was achieved with a 4.7 T animal system. Photothermal OCT and T(2) MRI achieved sensitivities of nanomolar concentrations to CNTs dispersed in amine-terminated polyethylene glycol, thus establishing the potential for dual-modality molecular imaging with CNTs.
authors.affiliation: Department of Biomedical Engineering, Vanderbilt University, VU Station B Box 351631, Nashville, Tennessee 37235, USA.
authors.forename: Jason M
authors.initials: JM
authors.lastname: Tucker-Schwartz
authors.forename: Tu
authors.initials: T
authors.lastname: Hong
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Colvin
authors.forename: Yaqiong
authors.initials: Y
authors.lastname: Xu
authors.forename: Melissa C
authors.initials: MC
authors.lastname: Skala
mesh_terms: D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging / Q000379:methods*; D037742:Nanotubes, Carbon / Q000032:analysis* / Q000737:chemistry*; D019047:Phantoms, Imaging; D013696:Temperature; D041623:Tomography, Optical Coherence / Q000379:methods*
chemical_list: D037742:Nanotubes, Carbon