title: Facile (triazolyl)methylation of MACOS-derived benzofused sultams utilizing ROMP-derived OTP reagents.
abstract: A combination of MACOS scale-out and ROMP-derived oligomeric triazole phosphates (OTP(n)) have been successfully utilized for the preparation of a 106-member library of triazole containing benzothiaoxazepine-1,1-dioxides. This report demonstrates the utilization of a suite of soluble OTP(n) reagents for facile (triazolyl)methylation of 10 MACOS-derived sultam scaffolds in purification-free process for parallel synthesis of small molecule collections for HTS.
authors.affiliation: Department of Chemistry, University of Kansas, Lawrence, 66045-7582, United States.
authors.forename: Saqib
authors.initials: S
authors.lastname: Faisal
authors.forename: Farman
authors.initials: F
authors.lastname: Ullah
authors.forename: Pradip K
authors.initials: PK
authors.lastname: Maity
authors.forename: Alan
authors.initials: A
authors.lastname: Rolfe
authors.forename: Thiwanka B
authors.initials: TB
authors.lastname: Samarakoon
authors.forename: Patrick
authors.initials: P
authors.lastname: Porubsky
authors.forename: Benjamin
authors.initials: B
authors.lastname: Neuenswander
authors.forename: Gerald H
authors.initials: GH
authors.lastname: Lushington
authors.forename: Fatima Z
authors.initials: FZ
authors.lastname: Basha
authors.forename: Michael G
authors.initials: MG
authors.lastname: Organ
authors.forename: Paul R
authors.initials: PR
authors.lastname: Hanson
mesh_terms: D001581:Benzothiadiazines / Q000138:chemical synthesis* / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D008745:Methylation; D008872:Microwaves; D015394:Molecular Structure; D010087:Oxides / Q000138:chemical synthesis* / Q000737:chemistry; D010710:Phosphates / Q000737:chemistry*; D054852:Small Molecule Libraries / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D014230:Triazoles / Q000737:chemistry*
chemical_list: D001581:Benzothiadiazines; D010087:Oxides; D010710:Phosphates; D054852:Small Molecule Libraries; D014230:Triazoles