title: Acute megakaryoblastic leukemia and severe pulmonary fibrosis in a child with Down syndrome: successful treatment with ultra low-dose cytarabine using GATA1 mutation to monitor minimal residual disease.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Moritake
authors.forename: Ai
authors.initials: A
authors.lastname: Yamada
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Kimoto
authors.forename: Daisuke
authors.initials: D
authors.lastname: Sawa
authors.forename: Hidemi
authors.initials: H
authors.lastname: Shimonodan
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nunoi
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage* / Q000627:therapeutic use; D015415:Biomarkers; D014408:Biomarkers, Tumor; D003561:Cytarabine / Q000008:administration & dosage* / Q000627:therapeutic use; D016207:Cytokines / Q000097:blood; D018450:Disease Progression; D004314:Down Syndrome / Q000150:complications*; D016903:Drug Monitoring; D005260:Female; D050982:GATA1 Transcription Factor / Q000097:blood / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000235:genetics* / Q000473:pathology; D007947:Leukemia, Megakaryoblastic, Acute / Q000188:drug therapy* / Q000209:etiology / Q000235:genetics / Q000473:pathology; D018396:Mucin-1 / Q000097:blood; D009196:Myeloproliferative Disorders / Q000151:congenital* / Q000235:genetics / Q000473:pathology; D009363:Neoplasm Proteins / Q000096:biosynthesis / Q000235:genetics*; D011241:Prednisone / Q000627:therapeutic use; D011658:Pulmonary Fibrosis / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D012074:Remission Induction
chemical_list: D000964:Antimetabolites, Antineoplastic; D015415:Biomarkers; D014408:Biomarkers, Tumor; D016207:Cytokines; D050982:GATA1 Transcription Factor; C494688:GATA1 protein, human; C060192:MUC1 protein, human; D018396:Mucin-1; D009363:Neoplasm Proteins; D003561:Cytarabine; D011241:Prednisone