title: trans-Chloro(1-naphthyl)bis(triphenylphosphine)nickel(II)/PCy3 catalyzed cross-coupling of aryl and heteroaryl neopentylglycolboronates with aryl and heteroaryl mesylates and sulfamates at room temperature.
abstract: trans-Chloro(1-naphthyl)bis(triphenylphosphine)nickel(II) complex/PCy(3) system has been successfully applied as catalyst for the Suzuki-Miyaura cross-coupling of aryl and heteroaryl neopentylglycolboronates with aryl and heteroaryl mesylates and sulfamates in THF at room temperature. This cross-coupling reaction tolerates various functional groups, including keto, imino, ester, ether, and cyano. Together with the nickel-catalyzed, one-pot, two-step neopentylglycolborylation, this bench stable and inexpensive Ni(II)-based catalyst can be utilized as an alternative to Ni(COD)(2)/PCy(3) to provide an inexpensive, robust, and convenient synthesis of biaryl and heterobiaryl compounds.
authors.affiliation: Roy & Diana Vagelos Laboratories, Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6323, USA.
authors.forename: Pawaret
authors.initials: P
authors.lastname: Leowanawat
authors.forename: Na
authors.initials: N
authors.lastname: Zhang
authors.forename: Mehtap
authors.initials: M
authors.lastname: Safi
authors.forename: David J
authors.initials: DJ
authors.lastname: Hoffman
authors.forename: Miriam C
authors.initials: MC
authors.lastname: Fryberger
authors.forename: Aiswaria
authors.initials: A
authors.lastname: George
authors.forename: Virgil
authors.initials: V
authors.lastname: Percec