title: A new biomarker that predicts colonic neoplasia outcome in patients with hyperplastic colonic polyps.
abstract: The most frequently occurring lesions in the colon are the hyperplastic polyps. Hyperplastic polyps have long been considered as lesions with no malignant potential and colonoscopy for these patients is not recommended. However, recent works suggest that hyperplastic polyps may represent precursor lesions of some sporadic colorectal cancers. Until now, no biomarker allows to identify the subset of hyperplastic polyps that may have a malignant potential. Because the hormone precursor progastrin has been involved in colon carcinogenesis, we investigated whether its expression in hyperplastic polyps predicts the occurrence of colonic neoplasm after resection of hyperplastic polyps. We retrospectively analyzed progastrin expression in hyperplastic polyps from 74 patients without history of colorectal pathology. In our study, 41% of patients presenting an initial hyperplastic polyp subsequently developed adenomatous polyps, recognized as precursor lesions for colorectal adenocarcinomas. Progastrin was overexpressed in the hyperplastic polyps in 40% of the patients. We showed a significant association between progastrin overexpression and shortened neoplasm-free survival (P = 0.001). Patients with high overexpression of progastrin had a 5-year neoplasm-free survival rate of 38% as compared with 100% for the patients with low progastrin expression. In addition, we established a predictive test on the basis of progastrin staining and patients' age that predicts occurrence of neoplasm after developing a first hyperplastic polyp with a sensitivity of 100% [95% confidence interval (CI), 79%-100%] and a specificity of 74% (51%-90%). We show that progastrin expression evaluation in hyperplastic polyps is an efficient prognostic tool to determine patients with higher risk of metachronous neoplasms who could benefit from an adapted follow-up.
authors.affiliation: INSERM, UMR1037 Cancer Research Center of Toulouse (CRCT), Université Paul Sabatier Toulouse III, 1 Avenue Jean Poulhés, BP 84225, 31432 Toulouse Cedex 4, Toulouse, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Do
authors.forename: Claudine
authors.initials: C
authors.lastname: Bertrand
authors.forename: Julien
authors.initials: J
authors.lastname: Palasse
authors.forename: Marie-Bernadette
authors.initials: MB
authors.lastname: Delisle
authors.forename: Arthur
authors.initials: A
authors.lastname: Shulkes
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Cohen-Jonathan-Moyal
authors.forename: Audrey
authors.initials: A
authors.lastname: Ferrand
authors.forename: Catherine
authors.initials: C
authors.lastname: Seva
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D015331:Cohort Studies; D003110:Colonic Neoplasms / Q000235:genetics* / Q000378:metabolism*; D003111:Colonic Polyps / Q000378:metabolism*; D018572:Disease-Free Survival; D005260:Female; D005755:Gastrins / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011498:Protein Precursors / Q000096:biosynthesis*; D012372:ROC Curve; D015203:Reproducibility of Results
chemical_list: D014408:Biomarkers, Tumor; D005755:Gastrins; D011498:Protein Precursors; C013706:big gastrin