title: Low-dose radiation induces Drosophila innate immunity through Toll pathway activation.
abstract: Numerous studies report that exposing certain organisms to low-dose radiation induces beneficial effects on lifespan, tumorigenesis, and immunity. By analyzing survival after bacterial infection and antimicrobial peptide gene expression in irradiated flies, we demonstrate that low-dose irradiation of Drosophila enhances innate immunity. Low-dose irradiation of flies significantly increased resistance against gram-positive and gram-negative bacterial infections, as well as expression of several antimicrobial peptide genes. Additionally, low-dose irradiation also resulted in a specific increase in expression of key proteins of the Toll signaling pathway and phosphorylated forms of p38 and JNK. These results indicate that innate immunity is activated after low-dose irradiation through Toll signaling pathway in Drosophila.
authors.affiliation: Division of Radiation Effect Research, Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., Ltd., Seoul, Korea 132-703.
authors.forename: Ki Moon
authors.initials: KM
authors.lastname: Seong
authors.forename: Cha Soon
authors.initials: CS
authors.lastname: Kim
authors.forename: Byung-Sub
authors.initials: BS
authors.lastname: Lee
authors.forename: Seon Young
authors.initials: SY
authors.lastname: Nam
authors.forename: Kwang Hee
authors.initials: KH
authors.lastname: Yang
authors.forename: Ji-Young
authors.initials: JY
authors.lastname: Kim
authors.forename: Joong-Jean
authors.initials: JJ
authors.lastname: Park
authors.forename: Kyung-Jin
authors.initials: KJ
authors.lastname: Min
authors.forename: Young-Woo
authors.initials: YW
authors.lastname: Jin
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000276:immunology / Q000517:prevention & control*; D004330:Drosophila / Q000276:immunology* / Q000382:microbiology / Q000528:radiation effects*; D029721:Drosophila Proteins / Q000276:immunology*; D007113:Immunity, Innate / Q000276:immunology* / Q000528:radiation effects; D011829:Radiation Dosage; D015398:Signal Transduction / Q000276:immunology* / Q000528:radiation effects*; D015996:Survival Rate; D051193:Toll-Like Receptors / Q000276:immunology*
chemical_list: D029721:Drosophila Proteins; C068721:Tl protein, Drosophila; D051193:Toll-Like Receptors