title: [Anti-inflammatory effects of amitriptyline, diazepam and mebicar using model of acute carrageenan-induced paw edema in rats].
abstract: The anti-inflammatory activity of amitriptyline, diazepam and a new, Russian tranquilizer mebicar was studied in a wide range of therapeutic doses on carrageenan-induced paw edema in rats. Mebicar at low doses showed greater and longer (up to 24 h) lasting anti-inflammatory activity as compared to that of amitriptyline and diazepam.
authors.forename: V N
authors.initials: VN
authors.lastname: Kaziakhmetova
authors.forename: I Kh
authors.initials: IKh
authors.lastname: Valeeva
authors.forename: L E
authors.initials: LE
authors.lastname: Ziganshina
mesh_terms: D000639:Amitriptyline / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D001736:Biureas / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D002351:Carrageenan / Q000494:pharmacology; D003975:Diazepam / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D005260:Female; D005534:Foot Diseases / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D051381:Rats
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001736:Biureas; C015979:mebikar; D000639:Amitriptyline; D002351:Carrageenan; D003975:Diazepam