title: Skin cancer and other cutaneous disorders in liver transplant recipients.
abstract: Patients who have received liver transplant are at increased risk of skin complications due to long-term immunosuppression regimen. The aim of this study was to analyze the incidence and risk factors of skin complications in liver transplant patients. We analyzed 161 liver transplant recipients. The mean age at transplantation was 47.4 years. Mean follow-up was 6 years. Seventy-one percent of patients presented with skin complications, including aestethic alterations, infections, precancerous lesions and malignancies, which represented 57%, 43%, 18% and 9%, respectively. Risk factors were: age at transplantation ≥ 45 years, immunosuppressive therapy with cyclosporine, and phototype II and III. Our study indicates that although liver transplant recipients are at greater risk of developing skin complications compared to the general population, the risk is lower than for other solid organ transplants, particularly for premalignant and malignant lesions.
authors.affiliation: Pediatric Dermatology Unit, University of Padua Via Cesare Battisti 206, IT-35128 Padova, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Belloni-Fortina
authors.forename: Stefano
authors.initials: S
authors.lastname: Piaserico
authors.forename: Matteo
authors.initials: M
authors.lastname: Bordignon
authors.forename: Martina
authors.initials: M
authors.lastname: Gambato
authors.forename: Marco
authors.initials: M
authors.lastname: Senzolo
authors.forename: Francesco Paolo
authors.initials: FP
authors.lastname: Russo
authors.forename: Andrea
authors.initials: A
authors.lastname: Peserico
authors.forename: Giuseppe
authors.initials: G
authors.lastname: De Matteis
authors.forename: Egle
authors.initials: E
authors.lastname: Perissinotto
authors.forename: Umberto
authors.initials: U
authors.lastname: Cillo
authors.forename: Alessandro
authors.initials: A
authors.lastname: Vitale
authors.forename: Mauro
authors.initials: M
authors.lastname: Alaibac
authors.forename: Patrizia
authors.initials: P
authors.lastname: Burra
mesh_terms: D000328:Adult; D000367:Age Factors; D016009:Chi-Square Distribution; D004359:Drug Therapy, Combination; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D015994:Incidence; D007558:Italy; D053208:Kaplan-Meier Estimate; D016031:Liver Transplantation / Q000009:adverse effects*; D016015:Logistic Models; D008875:Middle Aged; D015999:Multivariate Analysis; D018570:Risk Assessment; D012307:Risk Factors; D012871:Skin Diseases / Q000209:etiology* / Q000517:prevention & control; D012878:Skin Neoplasms / Q000209:etiology* / Q000517:prevention & control; D013472:Sunlight / Q000009:adverse effects; D013997:Time Factors
chemical_list: D007166:Immunosuppressive Agents