title: Bioactive phenolic amides from Celtis africana.
abstract: Nine compounds have been isolated for the first time from Celtis africana, namely trans-N-coumaroyltyramine (1), trans-N-feruloyltyramine (2), trans-N-caffeoyltyramine (3), lauric acid (4), oleic acid (5), palmitic acid (6), lupeol (7), β-sitosterol (8) and oleanolic acid (9), respectively. Their structures have been elucidated by different spectroscopic techniques. The isolated compounds were screened for their antioxidant, anti-inflammatory and acetylcholinestrease enzyme inhibitory activities. Compounds 1-3 showed significant antioxidant and anti-inflammatory activities and weak to moderate acetylcholinestrease enzyme inhibition activity.
authors.affiliation: Department of Pharmacogonosy, College of Pharmacy, King Saud University, Riyadh, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
authors.forename: Areej Mohammad
authors.initials: AM
authors.lastname: Al-Taweel
authors.forename: Shagufta
authors.initials: S
authors.lastname: Perveen
authors.forename: Azza Muhammed
authors.initials: AM
authors.lastname: El-Shafae
authors.forename: Ghada Ahmed
authors.initials: GA
authors.lastname: Fawzy
authors.forename: Abdul
authors.initials: A
authors.lastname: Malik
authors.forename: Nighat
authors.initials: N
authors.lastname: Afza
authors.forename: Lubna
authors.initials: L
authors.lastname: Iqbal
authors.forename: Mehreen
authors.initials: M
authors.lastname: Latif
mesh_terms: D000588:Amines / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D027581:Cannabaceae / Q000737:chemistry*; D002351:Carrageenan; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005227:Fatty Acids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D005260:Female; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008297:Male; D009828:Oleanolic Acid / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D053978:Pentacyclic Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010636:Phenols / Q000302:isolation & purification* / Q000494:pharmacology; D035261:Plant Components, Aerial / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012855:Sitosterols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000094042:Lupanes
chemical_list: D000588:Amines; D002351:Carrageenan; D002800:Cholinesterase Inhibitors; D005227:Fatty Acids; D016166:Free Radical Scavengers; D009828:Oleanolic Acid; D053978:Pentacyclic Triterpenes; D010636:Phenols; D010936:Plant Extracts; D012855:Sitosterols; C025473:gamma-sitosterol; C010480:lupeol; D000094042:Lupanes