title: Characteristics of earlier atherosclerotic involvement in adolescent patients with Kawasaki disease and coronary artery lesions: significance of gray scale median on B-mode ultrasound.
abstract: OBJECTIVE
  To test the hypothesis that textural changes in the carotid intima-media complex (IMC) detected by B-mode ultrasound are associated with the difference of remodeling process in earlier atherosclerotic involvement in patients with Kawasaki disease (KD) and coronary artery lesions (CALs).
  
  
  METHODS
  Eighteen patients with KD and CALs (mean age 17.2 years), 17 patients with heterozygous familial hypercholesterolemia (FH) (mean age 16.9 years) and 15 age-matched healthy controls (Cont) were assessed and compared for carotid intima-media thickness (CIMT), elastic property (E(p)), and first- and second-order statistics.
  
  
  RESULTS
  KD showed significantly higher gray scale median (GSM) than FH and Cont. KD and FH showed significantly higher CIMT, entropy and lower angular second moment than Cont, but no significant difference was found between KD and FH.
  
  
  CONCLUSIONS
  Higher GSM in KD may indicate alteration of tissue components and heterogeneity of IMC, suggesting the development of arteriosclerotic vascular remodeling after vasculitis. This is distinct from that of atherosclerosis with lower GSM often observed in FH.
authors.affiliation: Department of Pediatrics and Child Health, Nihon University School of Medicine 30-1 Oyaguchikami-machi, Itabashi-ku, Tokyo 173-8610, Japan. info@noto-clinic.com
authors.forename: Nobutaka
authors.initials: N
authors.lastname: Noto
authors.forename: Tomoo
authors.initials: T
authors.lastname: Okada
authors.forename: Yuriko
authors.initials: Y
authors.lastname: Abe
authors.forename: Michio
authors.initials: M
authors.lastname: Miyashita
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kanamaru
authors.forename: Kensuke
authors.initials: K
authors.lastname: Karasawa
authors.forename: Mamoru
authors.initials: M
authors.lastname: Ayusawa
authors.forename: Naokata
authors.initials: N
authors.lastname: Sumitomo
authors.forename: Hideo
authors.initials: H
authors.lastname: Mugishima
mesh_terms: D000293:Adolescent; D000328:Adult; D050197:Atherosclerosis / Q000000981:diagnostic imaging / Q000473:pathology*; D059168:Carotid Intima-Media Thickness; D005260:Female; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000000981:diagnostic imaging* / Q000473:pathology*; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology*