title: Direct amination of γ-halo-β-ketoesters with anilines.
abstract: The direct amination of α-haloacetoacetates with anilines is described. Compared to existing methods, this simple protocol provides an attractive strategy to prepare diverse γ-anilino-β-ketoesters in one step. Good to excellent yields of the amination products were obtained under robust conditions, providing versatile and useful scaffolds.
authors.affiliation: Department of Chemistry, Chemistry of Life Processes Institute, Center for Molecular Innovation and Drug Design, Northwestern University, Evanston, Illinois 60208-3113, USA.
authors.forename: Yinan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Richard B
authors.initials: RB
authors.lastname: Silverman
mesh_terms: D000586:Amination; D000814:Aniline Compounds / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D000814:Aniline Compounds; D002264:Carboxylic Acids; D006846:Hydrocarbons, Halogenated; C023650:aniline