title: A new biflavonoid with antiviral activity from the roots of Wikstroemia indica.
abstract: A new biflavonoid, 4'-methoxydaphnodorin E, was isolated from the antiviral fraction of Wikstroemia indica against respiratory syncytial virus (RSV). Its structure was determined on the basis of extensive spectroscopic data including HR-ESI-MS and 2D NMR. The biflavonoid was tested for its in vitro anti-RSV activity with cytopathic effect (CPE) reduction assay, and displayed potent effect with 50% inhibitory concentration (IC₅₀) value of 2.8 μM and selective index (SI) value of 5.4.
authors.affiliation: Biology Program, School of Life Science, The Chinese University of Hong Kong, New Territories, Hong Kong, SAR, China.
authors.forename: Wei-Huan
authors.initials: WH
authors.lastname: Huang
authors.forename: Guang-Xiong
authors.initials: GX
authors.lastname: Zhou
authors.forename: Guo-Cai
authors.initials: GC
authors.lastname: Wang
authors.forename: Hau-Yin
authors.initials: HY
authors.lastname: Chung
authors.forename: Wen-Cai
authors.initials: WC
authors.lastname: Ye
authors.forename: Yao-Lan
authors.initials: YL
authors.lastname: Li
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D044946:Biflavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D018517:Plant Roots / Q000737:chemistry; D012136:Respiratory Syncytial Viruses / Q000187:drug effects*; D032365:Wikstroemia / Q000737:chemistry*
chemical_list: C571644:4'-methoxydaphnodorin E; D000998:Antiviral Agents; D044946:Biflavonoids; D004365:Drugs, Chinese Herbal