title: Hepatoportal sclerosis clinical different evolutionary stages: presentation of 3 cases and literature review.
abstract: Hepatoportal sclerosis (HPS) is characterized by presinusoidal intrahepatic portal hypertension associated with splenomegaly and anemia in patients with non-cirrhotic liver. Liver biopsy is essential, especially to rule out other processes. Being a disease of unknown etiology, the majority of cases have been described in eastern countries. However, it may be an underdiagnosed disease in the West. Symptoms are related to portal hypertension and the clinical spectrum is wide, ranging from anemia with normal liver function tests to bleeding due to esophageal varices. Treatment is directed to the complications and the prognosis is better than in patients with cirrhosis.We report three cases of HPS presenting at different clinical stages and the findings of liver biopsies, the clinical outcomes and a review of scientific literature.
authors.affiliation: Department of Digestive Diseases, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain. alexmart82@hotmail.com
authors.forename: Alejandro
authors.initials: A
authors.lastname: Martínez-Caselles
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Pons-Miñano
authors.forename: Ángel
authors.initials: Á
authors.lastname: Vargas-Acosta
authors.forename: María Luisa
authors.initials: ML
authors.lastname: Ortiz-Sánchez
authors.forename: Cristina
authors.initials: C
authors.lastname: Martínez-Pascual
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Ruiz-Maciá
authors.forename: Belén
authors.initials: B
authors.lastname: Ferri
authors.forename: Eduardo
authors.initials: E
authors.lastname: Ortiz-Ruiz
authors.forename: Joaquín
authors.initials: J
authors.lastname: Sola
mesh_terms: D000328:Adult; D001706:Biopsy; D006801:Humans; D006975:Hypertension, Portal / Q000175:diagnosis* / Q000473:pathology; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010198:Pancytopenia / Q000175:diagnosis* / Q000473:pathology; D013163:Splenomegaly / Q000175:diagnosis* / Q000473:pathology; D000094724:Idiopathic Noncirrhotic Portal Hypertension