title: Protective effect of Hypericum perforatum L. on serum and hair trace elements in rats 7,12-dimethylbenz[a]anthracene-induced oxidative stress.
abstract: The study was designed to assess the effect of Hypericum perforatum L. (H.P) on serum and hair trace elements and mineral levels, oral administration of 7,12-dimethylbenz[a]anthracene (DMBA) induced oxidative stress in Sprague-Dawley female rats. Analysis of the trace element has been carried out using atomic absorption spectrophotometer method at end of 60th day. It has been found out that the DMBA group contained statistically lower Zn and Cr compared to the control group (p<0.01) and (p<0.05), Cu, Mg and Na contained higher than control group (p<0.05), (p<0.05) and (p<0.05). In DMBA+H.P group, Zn higher and Na lower than DMBA group (p<0.05), (p<0.05), in hair samples Cd, K and Zn contained lower DMBA compared to the control group (p<0.05), (p<0.05) and (p<0.05). In group DMBA+H.P, Cd was higher than DMBA group and Cr lowered accordance with control group (p<0.05). The present study demonstrated significantly positive and beneficial effect of H.P on the concentration levels of Zn and Na in serum, also on Cd levels in hair between DMBA and DMBA+H.P groups.
authors.affiliation: Yuzuncu Yil University, Department of Chemistry, Division of Biochemistry, Van, Turkey. suatekin@hotmail.com
authors.forename: Suat
authors.initials: S
authors.lastname: Ekin
authors.forename: Gokhan
authors.initials: G
authors.lastname: Oto
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Yardim
authors.forename: Abdulkadir
authors.initials: A
authors.lastname: Levent
authors.forename: Fevzi
authors.initials: F
authors.lastname: Ozgokce
authors.forename: Tuba
authors.initials: T
authors.lastname: Kusman
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity*; D000818:Animals; D002273:Carcinogens / Q000633:toxicity; D005260:Female; D006197:Hair / Q000737:chemistry*; D020902:Hypericum; D008670:Metals / Q000032:analysis* / Q000097:blood; D018384:Oxidative Stress / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D002273:Carcinogens; D008670:Metals; D010936:Plant Extracts; D015127:9,10-Dimethyl-1,2-benzanthracene