title: Flexing and stretching in nonribosomal Peptide synthetases.
abstract: Re-engineering of nonribosomal peptide synthetase molecular assembly lines has been hampered by a lack of detailed knowledge concerning inter-domain substrate transfer. Recent structural studies of catalytically relevant domain-domain interactions provide valuable insights into this problem (Liu et al., 2011; Sundlov et al., 2012 [in this issue of Chemistry & Biology]).
authors.affiliation: Institut für Biochemie und Biotechnologie, Martin-Luther-Universität Halle-Wittenberg, Kurt-Mothes-Straße 3, D-06120 Halle (Saale), Germany.
authors.forename: Sabrina
authors.initials: S
authors.lastname: Pfennig
authors.forename: Milton T
authors.initials: MT
authors.lastname: Stubbs
mesh_terms: D010453:Peptide Synthases / Q000737:chemistry*
chemical_list: D010453:Peptide Synthases