title: Antimetastasis effect of anthraquinones from marine fungus, Microsporum sp.
abstract: This chapter discusses about obtaining natural products which have anticancer metastasis activities from selected marine-derived fungus (Microsporum sp.) and investigates their biological activities such as cytotoxicity on viability cell lines, anticancer cell migration and invasion, protease inhibition, and expression of matrix metalloproteinase (MMP-2 and -9). Moreover, the correlative mechanisms behind these activities were studied.
authors.affiliation: School of Medicine, Tongji University, Shanghai, China.
authors.forename: Chen
authors.initials: C
authors.lastname: Zhang
authors.forename: Se-Kwon
authors.initials: SK
authors.lastname: Kim
mesh_terms: D000818:Animals; D000880:Anthraquinones / Q000378:metabolism* / Q000494:pharmacology* / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D059001:Aquatic Organisms / Q000378:metabolism*; D002465:Cell Movement / Q000187:drug effects; D055808:Drug Discovery; D004791:Enzyme Inhibitors / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D061965:Matrix Metalloproteinase Inhibitors; D020782:Matrix Metalloproteinases / Q000235:genetics / Q000378:metabolism; D008864:Microsporum / Q000378:metabolism*; D009183:Mycotoxins / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D009362:Neoplasm Metastasis / Q000517:prevention & control*
chemical_list: D000880:Anthraquinones; D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D061965:Matrix Metalloproteinase Inhibitors; D009183:Mycotoxins; D020782:Matrix Metalloproteinases