title: Organocatalytic asymmetric 1,4-addition of aldehydes to acridiniums catalyzed by a diarylprolinol silyl ether.
abstract: The organocatalytic enantioselective 1,4-addition of aldehydes to acridiniums catalyzed by diarylprolinol silyl ether was achieved to furnish chiral acridanes in both high yields (82-96%) and excellent enantioselectivities (up to 99% ee), which also provides the highly enantioselective intermolecular α-alkylation of aldehydes with acridiniums salt.
authors.affiliation: Dalian Institute of Chemical Physics, The Chinese Academy of Sciences, Dalian, 116023, PR China.
authors.forename: Tao
authors.initials: T
authors.lastname: Liang
authors.forename: Jian
authors.initials: J
authors.lastname: Xiao
authors.forename: Zhiyi
authors.initials: Z
authors.lastname: Xiong
authors.forename: Xingwei
authors.initials: X
authors.lastname: Li
mesh_terms: D000166:Acridines / Q000138:chemical synthesis* / Q000737:chemistry*; D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D004987:Ethers / Q000737:chemistry*; D015394:Molecular Structure; D011392:Proline / Q000031:analogs & derivatives* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000166:Acridines; D000447:Aldehydes; D004987:Ethers; C529940:diphenylprolinol silyl ether; D011392:Proline