title: Allosteric effects in a ditopic ligand containing bipyridine and tetra-aza-crown donor units.
abstract: Artificial allosterism: A ditopic ligand, which contains both bipyridine and tetra-aza-crown binding sites, coordinates one Cu(II) through all four N-donors of the tetradentate aza-crown unit. Reaction at the bipyridine site with another Cu(II) allosterically changes the aza-crown from being a tetradentate to a tridentate N-donor unit, a change in coordination mode that causes the successive binding of two Cu(II) ions to proceed with severe negative cooperativity (see scheme).
authors.affiliation: School of Applied Sciences, University of Huddersfield, Huddersfield HD1 3DH, UK.
authors.forename: Cara E
authors.initials: CE
authors.lastname: Sutton
authors.forename: Lindsay P
authors.initials: LP
authors.lastname: Harding
authors.forename: Michaele
authors.initials: M
authors.lastname: Hardie
authors.forename: Thomas
authors.initials: T
authors.lastname: Riis-Johannessen
authors.forename: Craig R
authors.initials: CR
authors.lastname: Rice
mesh_terms: D015082:2,2'-Dipyridyl / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D043844:Crown Ethers / Q000737:chemistry*; D018360:Crystallography, X-Ray; D006571:Heterocyclic Compounds / Q000737:chemistry*; D008024:Ligands; D008958:Models, Molecular; D009942:Organometallic Compounds / Q000737:chemistry*
chemical_list: D043844:Crown Ethers; D006571:Heterocyclic Compounds; D008024:Ligands; D009942:Organometallic Compounds; D015082:2,2'-Dipyridyl; D003300:Copper