title: Primary headache and epilepsy: a multicenter cross-sectional study.
abstract: The prevalence and characteristics of interictal headache, epilepsy and headache/epilepsy comorbidity were assessed in 858 women and 309 men aged 18-81 years from headache and epilepsy centers in Italy. The research hypothesis was that comorbidity among patients with either disorder would be expected to be higher than in the general population. Interictal headache was diagnosed in 675 cases (migraine 482; tension-type headache 168; other types 25), epilepsy in 336 (partial 171; generalized 165) and comorbidity in 156 (1.6% from headache centers; 30.0% from epilepsy centers). Patients with epilepsy, headache and comorbidity differed in a number of demographic and clinical aspects. However, for both headache and epilepsy, a family history of the same clinical condition was equally prevalent in patients with and without comorbidity. These findings do not support the purported association between headache and epilepsy.
authors.affiliation: Department of Neurology, Headache Center, G. Salvini Hospital, Garbagnate Mse (MI), Italy.
authors.forename: M C
authors.initials: MC
authors.lastname: Tonini
authors.forename: L
authors.initials: L
authors.lastname: Giordano
authors.forename: L
authors.initials: L
authors.lastname: Atzeni
authors.forename: G
authors.initials: G
authors.lastname: Bogliun
authors.forename: G
authors.initials: G
authors.lastname: Perri
authors.forename: M G
authors.initials: MG
authors.lastname: Saracco
authors.forename: M
authors.initials: M
authors.lastname: Tombini
authors.forename: P
authors.initials: P
authors.lastname: Torelli
authors.forename: M
authors.initials: M
authors.lastname: Turazzini
authors.forename: F
authors.initials: F
authors.lastname: Vernieri
authors.forename: M
authors.initials: M
authors.lastname: Aguggia
authors.forename: G
authors.initials: G
authors.lastname: Bussone
authors.forename: E
authors.initials: E
authors.lastname: Beghi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016009:Chi-Square Distribution; D015897:Comorbidity; D003430:Cross-Sectional Studies; D004827:Epilepsy / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D051270:Headache Disorders, Primary / Q000145:classification / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D055815:Young Adult