title: A preliminary retrospective study about the relationship between ductus venosus Doppler indices, nuchal translucency (NT) and biochemical markers in the first and second trimester screening tests.
abstract: In our study, we tried to assess the relation between ductus venosus Doppler indices [pulsatility index (PI), resistance index (RI) and S/D] and first-trimester screening markers (MoM of serum pregnancy-associated plasma protein A, pappalysin 1 (PAPP-A), MoM of serum free β-human chorionic gonadotrophin (β-hCG), and nuchal translucency (NT) and second trimester screening markers (MoM of serum α-fetoprotein, MoM of serum total β-hCG and MoM of serum estriol). We analyzed the data of 121 singleton pregnancies. Roche cobas e 601ECLIA (electrochemiluminescence immunoassay) was used to measure MoM of serum PAPP-A and Roche cobas e 602 ECLIA (electrochemiluminescence immunoassay) was used to measure MoM of serum free β-hCG in the first trimester. Beckman Coulter Access 2 Immunoassay was used to measure MoM of serum α-fetoprotein, MoM of serum total β-hCG and MoM of serum estriol in the second trimester. The first author performed all ultrasound screenings and ductus venosus Doppler studies. What we found new in our study is presented as following; MoM of serum α-fetoprotein had a negative correlation with RI of ductus venosus Doppler, MoM of serum estriol had a negative correlation with RI of ductus venosus Doppler and MoM of serum estriol had a negative correlation with S/D of ductus venosus doppler. The results of our study suggest that ductus venosus Doppler can be used to increase the effectiveness of the second trimester screening test.
authors.affiliation: Department of Obstetrics and Gynecology, Gaziosmanpasa University, Tokat, Turkey. fazlimd@yahoo.com
authors.forename: Fazli
authors.initials: F
authors.lastname: Demirturk
authors.forename: Ahmet Cantug
authors.initials: AC
authors.lastname: Caliskan
authors.forename: Hakan
authors.initials: H
authors.lastname: Aytan
authors.forename: Semsettin
authors.initials: S
authors.lastname: Sahin
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood*; D002869:Chromosome Aberrations; D005260:Female; D005333:Fetus / Q000098:blood supply*; D006801:Humans; D008403:Mass Screening; D048208:Nuchal Translucency Measurement; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000097:blood; D011262:Pregnancy Trimester, Second / Q000097:blood; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D015415:Biomarkers