title: Exploiting effectors of Rac GTPase.
abstract: Targeting a specific arm of signaling pathways is of great interest. In this issue of Chemistry & Biology, Bosco et al. exploit the interactive interface between Rac GTPase and its effector p67(phox) to specifically inhibit reactive oxygen species production without perturbing other Rac-mediated cellular processes.
authors.affiliation: Environmental Health Sciences, Yale University School of Public Health, 7th Floor, 1 Church Street, New Haven, CT 06510, USA. hakryul.jo@yale.edu
authors.forename: Hakryul
authors.initials: H
authors.lastname: Jo
authors.forename: Hongbo R
authors.initials: HR
authors.lastname: Luo
mesh_terms: D048588:Benzoxazines / Q000494:pharmacology*; D015195:Drug Design; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D010750:Phosphoproteins / Q000037:antagonists & inhibitors*; D011720:Pyrazoles / Q000494:pharmacology*; D015398:Signal Transduction / Q000187:drug effects*; D020744:rac GTP-Binding Proteins / Q000037:antagonists & inhibitors*
chemical_list: D048588:Benzoxazines; D010750:Phosphoproteins; C573130:Phox-I1; D011720:Pyrazoles; C079789:neutrophil cytosol factor 67K; D020744:rac GTP-Binding Proteins