title: [Influence of Tiangou Jiangya capsule on blood pressure in renovascular hypertension rats].
abstract: OBJECTIVE
  To observe the effect of Tiangou Jiangya capsule (TJC) on blood pressure in renovascular hypertension rats and explore its possible mechanism.
  
  
  METHODS
  Seventy-two Wistar rats were randomly divided into normal control group, model group, captopril group, TJC small, medium and high dose groups. Non-invasive blood pressure measurement was used to detect the arterial blood pressure of rat tails. PRA, Ang II , ALD, 6-Keto-PGF1alpha, ET and TXB2 content in blood was measured by radioimmunoassay. NO content in blood was determined by method of nitrate reductase.
  
  
  RESULTS
  The systolic, diastolic and mean pressure significantly increased, serum PRA, Ang II , ALD decreased, ET levels significantly increased in model group rats. TJC significantly reduced blood pressure, improved the plasma renin activity, decreased ET levels and increased NO content of model rats.
  
  
  CONCLUSIONS
  TJC can reduce blood pressure of renovascular hypertention rats, and the mechanism may be related to its regulating lower blood pressure regulation of the secretion of RAAS system and improving vascular endothelial function.
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Yang
authors.forename: Yujie
authors.initials: Y
authors.lastname: Li
authors.forename: Xiaoni
authors.initials: X
authors.lastname: Liu
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Weng
authors.forename: Ying
authors.initials: Y
authors.lastname: Chen
authors.forename: Xiaoxin
authors.initials: X
authors.lastname: Zhu
authors.forename: Xiao
authors.initials: X
authors.lastname: Han
authors.forename: Lijuan
authors.initials: L
authors.lastname: Zou
authors.forename: Dan
authors.initials: D
authors.lastname: Li
mesh_terms: D000804:Angiotensin II / Q000097:blood; D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D001592:Benzyl Alcohols / Q000494:pharmacology* / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D005419:Flavonoids / Q000494:pharmacology* / Q000627:therapeutic use*; D005663:Furans / Q000494:pharmacology* / Q000627:therapeutic use*; D005960:Glucosides / Q000494:pharmacology* / Q000627:therapeutic use*; D006978:Hypertension, Renovascular / Q000097:blood / Q000188:drug therapy*; D017705:Lignans / Q000494:pharmacology* / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System / Q000187:drug effects
chemical_list: D000959:Antihypertensive Agents; D001592:Benzyl Alcohols; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D005663:Furans; D005960:Glucosides; D017705:Lignans; C560376:Tiangou; D000804:Angiotensin II; D012083:Renin