title: Comparison of the peroxidase-like activity of unmodified, amino-modified, and citrate-capped gold nanoparticles.
abstract: The origin of the peroxidase-like activity of gold nanoparticles and the impact of surface modification are studied. Furthermore, some influencing factors, such as fabrication process, redox property of the modifier, and charge property of the substrate, are investigated. Compared to amino-modified or citrate-capped gold nanoparticles, unmodified gold nanoparticles show significantly higher catalytic activity toward peroxidase substrates, that is, the superficial gold atoms are a contributing factor to the observed peroxidase-like activity. The different catalytic activities of amino-modified and citrate-capped gold nanoparticles toward 3,3',5,5'-tetramethylbenzidine (TMB) and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) diammonium salt (ABTS) show that the charge characteristics of the nanoparticles and the substrate also play an important role in the catalytic reactions.
authors.affiliation: Department of Pharmaceutical Analysis, Fujian Medical University, Fuzhou 350004, China.
authors.forename: Sheng
authors.initials: S
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.forename: Ai-Lin
authors.initials: AL
authors.lastname: Liu
authors.forename: Lei
authors.initials: L
authors.lastname: Hong
authors.forename: Hao-Hua
authors.initials: HH
authors.lastname: Deng
authors.forename: Xin-Hua
authors.initials: XH
authors.lastname: Lin
mesh_terms: D000588:Amines / Q000737:chemistry*; D001560:Benzidines / Q000737:chemistry; D052160:Benzothiazoles / Q000737:chemistry; D040761:Biomimetic Materials / Q000138:chemical synthesis*; D002384:Catalysis; D002951:Citrates / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D046529:Microscopy, Electron, Transmission; D010084:Oxidation-Reduction; D009195:Peroxidase / Q000737:chemistry; D013057:Spectrum Analysis; D055672:Static Electricity; D013451:Sulfonic Acids / Q000737:chemistry; D013499:Surface Properties
chemical_list: D000588:Amines; D001560:Benzidines; D052160:Benzothiazoles; D002951:Citrates; D013451:Sulfonic Acids; C002502:2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid; C021758:3,3',5,5'-tetramethylbenzidine; D006046:Gold; D009195:Peroxidase