title: [Evaluation of the effect of the traditional Chinese medicine tongxinluo or ginseng on excess fatigue rats studied by metabonomics approach based on liquid chromatography-mass spectrometry].
abstract: Excess fatigue is a pathological state of continuing accumulation of fatigue, which may cause the deterioration of body health, occurrence of diseases, and even lead to death. A metabonomics study was performed on the excess fatigue rats treated with traditional Chinese medicine Tongxinluo or ginseng based on ultra fast liquid chromatography coupled with ion trap-time of flight mass spectrometry (UFLC-IT-TOF-MS). The plasma metabolic profiling data of the control rats, excess fatigue rats, and excess fatigue rats treated with Tongxinluo or ginseng were acquired. The orthogonal partial least squares analysis (OPLS) was applied for the multivariate statistics and the discovery of important differential metabolites distinguishing the excess fatigue rats treated with Tongxinluo or ginseng from the control rats and excess fatigue rats. The results showed tryptophan, bile acid, lysophosphatidylcholine metabolism were disturbed in the excess fatigue rats. The metabolic pattern including the related metabolic pathways of the rats, being treated with Tongxinluo or ginseng, was adjusted towards the normal state.
authors.affiliation: CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
authors.forename: Weidong
authors.initials: W
authors.lastname: Dai
authors.forename: Fengxia
authors.initials: F
authors.lastname: Zhang
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Jia
authors.forename: Cong
authors.initials: C
authors.lastname: Wei
authors.forename: Peng
authors.initials: P
authors.lastname: Gao
authors.forename: Xin
authors.initials: X
authors.lastname: Lu
authors.forename: Yiling
authors.initials: Y
authors.lastname: Wu
authors.forename: Guowang
authors.initials: G
authors.lastname: Xu
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism; D002352:Carrier Proteins; D002853:Chromatography, Liquid / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005221:Fatigue / Q000188:drug therapy / Q000378:metabolism*; D008244:Lysophosphatidylcholines / Q000378:metabolism; D008297:Male; D013058:Mass Spectrometry / Q000379:methods*; D008562:Membrane Glycoproteins; D055432:Metabolomics / Q000379:methods*; D005894:Panax / Q000737:chemistry*; D008517:Phytotherapy; D051381:Rats; D017207:Rats, Sprague-Dawley; D014364:Tryptophan / Q000378:metabolism
chemical_list: D001647:Bile Acids and Salts; D002352:Carrier Proteins; D004365:Drugs, Chinese Herbal; D008244:Lysophosphatidylcholines; D008562:Membrane Glycoproteins; C037643:bile acid binding proteins; C513941:tongxinluo; D014364:Tryptophan