title: Integrated approach toward the discovery of glyco-biomarkers of inflammation-related diseases.
abstract: Glycobiology has contributed tremendously to the discovery and characterization of cancer-related biomarkers containing glycans (i.e., glyco-biomarkers) and a more detailed understanding of cancer biology. It is now recognized that most chronic diseases involve some elements of chronic inflammation; these include cancer, Alzheimer's disease, and metabolic syndrome (including consequential diabetes mellitus and cardiovascular diseases). By extending the knowledge and experience of the glycobiology community regarding cancer biomarker discovery, we should be able to contribute to the discovery of diagnostic/prognostic glyco-biomarkers of other chronic diseases that involve chronic inflammation. Future integration of large-scale "omics"-type data (e.g., genomics, epigenomics, transcriptomics, proteomics, and glycomics) with computational model building, or a systems glycobiology approach, will facilitate such efforts.
authors.affiliation: Systems Glycobiology Research Group, Chemical Biology Department, RIKEN Advanced Science Institute, Wako, Saitama, Japan. angata@riken.jp
authors.forename: Takashi
authors.initials: T
authors.lastname: Angata
authors.forename: Reiko
authors.initials: R
authors.lastname: Fujinawa
authors.forename: Ayako
authors.initials: A
authors.lastname: Kurimoto
authors.forename: Kazuki
authors.initials: K
authors.lastname: Nakajima
authors.forename: Masaki
authors.initials: M
authors.lastname: Kato
authors.forename: Shinji
authors.initials: S
authors.lastname: Takamatsu
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Korekane
authors.forename: Cong-Xiao
authors.initials: CX
authors.lastname: Gao
authors.forename: Kazuaki
authors.initials: K
authors.lastname: Ohtsubo
authors.forename: Shinobu
authors.initials: S
authors.lastname: Kitazume
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Taniguchi
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism; D015415:Biomarkers / Q000737:chemistry / Q000378:metabolism; D005260:Female; D054794:Glycomics; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D008297:Male; D011134:Polysaccharides / Q000737:chemistry / Q000378:metabolism*; D029424:Pulmonary Disease, Chronic Obstructive / Q000378:metabolism; D049490:Systems Biology
chemical_list: D015415:Biomarkers; D011134:Polysaccharides