title: MicroRNA-663 targets TGFB1 and regulates lung cancer proliferation.
abstract: MicroRNAs (miRNAs) play critical roles in many different cellular processes, including metabolism, apoptosis, differentiation, and development. In this study, miR-663 was shown to be highly expressed in patients with lung cancer. Furthermore, miR-663 contributed to lung cancer cell proliferation of by regulating TGFB1, P53, Bax, and Fas directly or indirectly. Our results demonstrated that miR-663 plays an important role in the biology of lung cancer and may be useful in developing therapies targeting genes.
authors.affiliation: Hebei United University Affiliated Hospital, Tang Shan, China.
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Liu
authors.forename: Guang-Ling
authors.initials: GL
authors.lastname: Zhang
authors.forename: Mei-Mei
authors.initials: MM
authors.lastname: Wang
authors.forename: Ya-Nan
authors.initials: YN
authors.lastname: Xiong
authors.forename: He-Qin
authors.initials: HQ
authors.lastname: Cui
mesh_terms: D017209:Apoptosis / Q000235:genetics; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D053222:Fas Ligand Protein / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000378:metabolism*; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D053773:Transforming Growth Factor beta1 / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D051028:bcl-2-Associated X Protein / Q000378:metabolism
chemical_list: C494826:BAX protein, human; C505661:FASLG protein, human; D053222:Fas Ligand Protein; C552243:MIRN663 microRNA, human; D035683:MicroRNAs; C508960:TGFB1 protein, human; C495901:TP53 protein, human; D053773:Transforming Growth Factor beta1; D016159:Tumor Suppressor Protein p53; D051028:bcl-2-Associated X Protein