title: Carbon nanotubes-ionic liquid nanocomposites sensing platform for NADH oxidation and oxygen, glucose detection in blood.
abstract: An excellent electrochemical sensing platform has been designed by combining the huge specific surface area of carbon nanotubes (CNTs) and the remarkable conductivity of ionic liquid (IL). IL can easily untangle CNTs bundles and disperse CNTs by itself under grinding condition due to the π-π interaction between CNTs and IL. The resulting nanocomposites showed an augmentation on the voltammetric and amperometric behaviors of electrocatalytic activity toward O(2) and NADH. Therefore, such an efficient platform was developed to fabricate mediator-free oxygen sensor and glucose biosensor based on glucose dehydrogenase (GDH). O(2) could be determined in the range of zero to one hundred percent of O(2) content with the detection limit of 126 μg L(-1) (S/N=3). The glucose biosensor which was constructed by entrapping GDH into chitosan on the nanocomposites modified glassy carbon electrode surface, exhibited good electrocatalytic oxidation toward glucose with a detection limit of 9 μM in the linear range of 0.02-1mM. We also applied the as-prepared sensors to detect oxygen and glucose in real blood samples and acquired satisfied results.
authors.affiliation: State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, PR China.
authors.forename: Lu
authors.initials: L
authors.lastname: Bai
authors.forename: Dan
authors.initials: D
authors.lastname: Wen
authors.forename: Jianyuan
authors.initials: J
authors.lastname: Yin
authors.forename: Liu
authors.initials: L
authors.lastname: Deng
authors.forename: Chengzhou
authors.initials: C
authors.lastname: Zhu
authors.forename: Shaojun
authors.initials: S
authors.lastname: Dong
mesh_terms: D015374:Biosensing Techniques / Q000379:methods* / Q000592:standards; D001786:Blood Glucose / Q000032:analysis*; D042843:Glucose 1-Dehydrogenase; D006801:Humans; D052578:Ionic Liquids; D057230:Limit of Detection; D009243:NAD / Q000737:chemistry; D053761:Nanocomposites / Q000737:chemistry*; D037742:Nanotubes, Carbon; D010100:Oxygen
chemical_list: D001786:Blood Glucose; D052578:Ionic Liquids; D037742:Nanotubes, Carbon; D009243:NAD; D042843:Glucose 1-Dehydrogenase; D010100:Oxygen