title: Objective and subjective changes in voice quality after radiotherapy for early (T1 or T2, N0) laryngeal cancer: a pilot prospective cohort study.
abstract: BACKGROUND
  Limited data exist on long-term voice quality after treatment for early laryngeal cancer. We report on the feasibility of establishing a dedicated service to assess changes after radiotherapy.
  
  
  METHODS
  From June 1999 to December 2005, all patients referred for radical radiotherapy for early laryngeal cancers were invited to join a prospective cohort study. Subjective and objective voice quality tests were performed before and after treatment and at 3, 6, 12, and 24 months after treatment.
  
  
  RESULTS
  Twenty-seven patients were screened for the study. Sufficient data were available for 15 (56%) patients. Both subjective and objective assessments improved significantly.
  
  
  CONCLUSIONS
  This pilot study shows that it is possible to collect prospective voice quality data. There are both subjective and objective improvements in voice that persist to at least 2 years after radiotherapy. We propose the use of the methods described here to study voice outcomes in a lager cohort of patients treated with both surgery and radiotherapy.
authors.affiliation: Department of Radiation Oncology, Royal Adelaide Hospital, Adelaide, South Australia, Australia. adams_gerard@hotmail.com
authors.forename: Gerard
authors.initials: G
authors.lastname: Adams
authors.forename: Robyn
authors.initials: R
authors.lastname: Burnett
authors.forename: Ellen
authors.initials: E
authors.lastname: Mills
authors.forename: Michael
authors.initials: M
authors.lastname: Penniment
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000503:physiopathology / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011446:Prospective Studies; D016896:Treatment Outcome; D014832:Voice Disorders / Q000175:diagnosis*; D014833:Voice Quality / Q000528:radiation effects*