title: MicroRNA-409-3p regulates cell proliferation and apoptosis by targeting PHF10 in gastric cancer.
abstract: Emerging evidence has indicated microRNAs are involved in tumor development and progression, acting as tumor suppressors or oncogenes. Here we report that miR-409-3p was significantly downregulated in gastric cancer (GC) cell lines and tissues. Overexpression of miR-409-3p in SGC-7901 gastric cancer cells dramatically suppressed cell proliferation and induced cell apoptosis both in vitro and in vivo. Furthermore, we demonstrate that the transcriptional regulator PHF10 was a target of miR-409-3p. Taken together, these findings suggest that miR-409-3p may function as a novel tumor suppressor in GC and its anti-oncogenic activity may involve the direct targeting and inhibition of PHF10.
authors.affiliation: Shanghai Key Laboratory of Gastric Neoplasms, Department of Surgery, Shanghai Institute of Digestive Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
authors.forename: Chenglong
authors.initials: C
authors.lastname: Li
authors.forename: Hui
authors.initials: H
authors.lastname: Nie
authors.forename: Ming
authors.initials: M
authors.lastname: Wang
authors.forename: Liping
authors.initials: L
authors.lastname: Su
authors.forename: Jianfang
authors.initials: J
authors.lastname: Li
authors.forename: Beiqin
authors.initials: B
authors.lastname: Yu
authors.forename: Min
authors.initials: M
authors.lastname: Wei
authors.forename: Jingfang
authors.initials: J
authors.lastname: Ju
authors.forename: Yingyan
authors.initials: Y
authors.lastname: Yu
authors.forename: Min
authors.initials: M
authors.lastname: Yan
authors.forename: Qinlong
authors.initials: Q
authors.lastname: Gu
authors.forename: Zhenggang
authors.initials: Z
authors.lastname: Zhu
authors.forename: Bingya
authors.initials: B
authors.lastname: Liu
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D015536:Down-Regulation; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D018398:Homeodomain Proteins / Q000037:antagonists & inhibitors / Q000235:genetics*; D006801:Humans; D008297:Male; D051379:Mice; D008819:Mice, Nude; D035683:MicroRNAs / Q000502:physiology*; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors / Q000235:genetics*; D009368:Neoplasm Transplantation; D013274:Stomach Neoplasms / Q000235:genetics*; D014162:Transfection
chemical_list: D018398:Homeodomain Proteins; C572367:MIRN409 microRNA, human; D035683:MicroRNAs; D009363:Neoplasm Proteins; C552094:PHF10 protein, human