title: Dimethyl acetals, an indirect marker of the endogenous antioxidant plasmalogen level, are reduced in blood lipids of Sudanese pre-eclamptic subjects whose background diet is high in carbohydrate.
abstract: In Sudanese women with (n = 60) and without (n = 65) pre-eclampsia, circulating lipids, plasma and red cell saturated and monounsaturated fatty (MUFA) acids and dimethyl acetals (DMAs) were investigated. DMAs are an indirect marker of levels of plasmalogens, endogenous antioxidants, which play a critical role in oxidative protection, and cholesterol homeostasis. The pre-eclamptics had higher C18:1n-9 (p < 0.001) and ΣMUFA (p < 0.01) in plasma free fatty acids, C16:1n-7, C18:1n-9, ΣMUFA; 16:0/16:1n-7 (p < 0.01) in erythrocyte choline phosphoglycerides (ePC) and 16:1n-7, 18:1n-7 and 16:0/16:1n-7 (p < 0.01) in erythrocyte ethanolamine phosphoglycerides (ePE). In contrast, the DMAs 18:0, 18:1 and ΣDMAs in ePE, and 16:0, 18:0 and ΣDMAs in ePC were reduced (p < 0.001) in the pre-eclamptic women. This study of pregnant women with high carbohydrate and low fat background diet suggests pre-eclampsia is associated with oxidative stress and enhanced activity of the microsomal enzyme stearyl-CoA desaturase (delta 9 desaturase), as assessed by palmitic/palmitoleic (C16:0/C16:n-1) and stearic/oleic (C18/C18:1n-9) ratios.
authors.affiliation: Institute of Brain Chemistry and Human Nutrition, London Metropolitan University, UK. a.amadorbueno@londonmet.ac.uk
authors.forename: A A
authors.initials: AA
authors.lastname: Bueno
authors.forename: K
authors.initials: K
authors.lastname: Ghebremeskel
authors.forename: K H
authors.initials: KH
authors.lastname: Bakheit
authors.forename: M I
authors.initials: MI
authors.lastname: Elbashir
authors.forename: I
authors.initials: I
authors.lastname: Adam
mesh_terms: D000080:Acetals / Q000097:blood*; D000975:Antioxidants; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D004032:Diet; D004040:Dietary Carbohydrates; D004912:Erythrocytes / Q000378:metabolism*; D005227:Fatty Acids / Q000097:blood*; D005260:Female; D006801:Humans; D018384:Oxidative Stress; D010713:Phosphatidylcholines / Q000097:blood; D010714:Phosphatidylethanolamines / Q000097:blood; D010955:Plasmalogens / Q000097:blood; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D013397:Sudan; D014280:Triglycerides / Q000097:blood
chemical_list: D000080:Acetals; D000975:Antioxidants; D015415:Biomarkers; D004040:Dietary Carbohydrates; D005227:Fatty Acids; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D010955:Plasmalogens; D014280:Triglycerides; D002784:Cholesterol; C059033:1,1-dimethoxyethane