title: Patients with autoimmune hepatitis who have antimitochondrial antibodies need long-term follow-up to detect late development of primary biliary cirrhosis.
abstract: Patients with autoimmune hepatitis (AIH) who have antibodies against mitochondrial proteins (AMA positive) are believed to have an autoimmune syndrome that should be managed as AIH. Of patients with AMA-positive AIH, we report on 3 individuals to demonstrate how autoimmune liver disease can progress over time. Specific features of primary biliary cirrhosis (PBC) overlapped in time in these patients. Our observations indicate the importance of careful follow up of patients with AMA-positive AIH; health care professionals that treat such patients should therefore be aware of longitudinal clinical changes that might indicate development of PBC in this setting.
authors.affiliation: Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Amreen M
authors.initials: AM
authors.lastname: Dinani
authors.forename: Sandra E
authors.initials: SE
authors.lastname: Fischer
authors.forename: Jeff
authors.initials: J
authors.lastname: Mosko
authors.forename: Maha
authors.initials: M
authors.lastname: Guindi
authors.forename: Gideon M
authors.initials: GM
authors.lastname: Hirschfield
mesh_terms: D000368:Aged; D000906:Antibodies / Q000097:blood*; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D019693:Hepatitis, Autoimmune / Q000150:complications*; D006651:Histocytochemistry; D006801:Humans; D007150:Immunohistochemistry; D008099:Liver / Q000473:pathology; D008105:Liver Cirrhosis, Biliary / Q000175:diagnosis*; D008853:Microscopy; D008875:Middle Aged; D008928:Mitochondria / Q000276:immunology*
chemical_list: D000906:Antibodies