title: Pathological impairments induced by interstitial implantation of 125I seeds in spinal canal of banna mini-pigs.
abstract: BACKGROUND
  Use a banna mini-pig to set up 125I implantation model, and investigate the consequence of radiation-related impairments.
  
  
  METHODS
  In present study, 125I seeds were implanted into spinal canal of T13 level of spine in banna mini-pigs. After operation, the pigs were raised up to 8 months, behavior changes were recorded within this period. After 8 months, spinal cords were collected for pathological analysis.
  
  
  RESULTS
  In this study, a 125I brachytherapy animal model had been successfully established, in the model group, the banna pigs' Tarlov scale decreased from 5 to 2.57 ± 0.36, significant cellular impairments were noted by pathological analysis.
  
  
  CONCLUSIONS
  Without any protection and operation improvement, 125I implantation can cause serious histological impairments and moving difficulty for banna mini-pigs; this present research provides an alternative tool to study spinal 125I brachytherapy.
authors.affiliation: Department of Orthopaedics, Kunming General Hospital of Chengdu Military Command, Kunming, Yunnan 650118, PR China. yangzuozhangsci@163.com
authors.forename: Zuozhang
authors.initials: Z
authors.lastname: Yang
authors.forename: Yongqing
authors.initials: Y
authors.lastname: Xu
authors.forename: Dakuan
authors.initials: D
authors.lastname: Yang
authors.forename: Hongpu
authors.initials: H
authors.lastname: Sun
authors.forename: Ruilian
authors.initials: R
authors.lastname: Zhao
authors.forename: Jin
authors.initials: J
authors.lastname: Zhang
authors.forename: Xiaoxue
authors.initials: X
authors.lastname: Wang
authors.forename: Hua
authors.initials: H
authors.lastname: Jiang
authors.forename: Lie
authors.initials: L
authors.lastname: Xu
authors.forename: Jinlei
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001918:Brachytherapy; D005260:Female; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D013115:Spinal Canal / Q000473:pathology* / Q000528:radiation effects*; D013118:Spinal Cord Diseases / Q000532:radiotherapy*; D013552:Swine; D013556:Swine, Miniature
chemical_list: D007457:Iodine Radioisotopes