title: CD86 is expressed on murine hematopoietic stem cells and denotes lymphopoietic potential.
abstract: A unique subset of CD86(-) HSCs was previously discovered in mice that were old or chronically stimulated with lipopolysaccharide. Functionally defective HSCs were also present in those animals, and we now show that CD86(-) CD150(+) CD48(-) HSCs from normal adult mice are particularly poor at restoring the adaptive immune system. Levels of the marker are high on all progenitors with lymphopoietic potential, and progressive loss helps to establish relations between progenitors corresponding to myeloid and erythroid lineages. CD86 represents an important tool for subdividing HSCs in several circumstances, identifying those unlikely to generate a full spectrum of hematopoietic cells.
authors.affiliation: Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Shimazu
authors.forename: Ryuji
authors.initials: R
authors.lastname: Iida
authors.forename: Qingzhao
authors.initials: Q
authors.lastname: Zhang
authors.forename: Robert S
authors.initials: RS
authors.lastname: Welner
authors.forename: Kay L
authors.initials: KL
authors.lastname: Medina
authors.forename: José
authors.initials: J
authors.lastname: Alberola-Lla
authors.forename: Paul W
authors.initials: PW
authors.lastname: Kincade
mesh_terms: D000818:Animals; D051940:B7-2 Antigen / Q000235:genetics* / Q000378:metabolism / Q000502:physiology*; D002454:Cell Differentiation / Q000235:genetics / Q000276:immunology; D002478:Cells, Cultured; D005260:Female; D015870:Gene Expression; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000378:metabolism* / Q000502:physiology; D038041:Lymphopoiesis / Q000235:genetics* / Q000502:physiology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D022423:Myeloid Cells / Q000166:cytology / Q000378:metabolism / Q000502:physiology; D010641:Phenotype
chemical_list: D051940:B7-2 Antigen; C497965:Cd86 protein, mouse