title: Multiple modes of cytoplasmic dynein regulation.
abstract: In performing its multiple cellular functions, the cytoplasmic dynein motor is subject to complex regulation involving allosteric mechanisms within the dynein complex, as well as numerous extramolecular interactions controlling subcellular targeting and motor activity. Recent work has distinguished high- and low-load regulatory modes for cytoplasmic dynein, which, combined with a diversity of targeting mechanisms, accounts for a very broad range of functions.
authors.affiliation: Department of Pathology and Cell Biology, Columbia University, New York, New York 10032, USA. rv2025@columbia.edu
authors.forename: Richard B
authors.initials: RB
authors.lastname: Vallee
authors.forename: Richard J
authors.initials: RJ
authors.lastname: McKenney
authors.forename: Kassandra M
authors.initials: KM
authors.lastname: Ori-McKenney
mesh_terms: D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase / Q000378:metabolism*; D000818:Animals; D001692:Biological Transport; D002352:Carrier Proteins / Q000378:metabolism*; D056445:Cytoplasmic Dyneins / Q000737:chemistry / Q000378:metabolism*; D000072159:Dynactin Complex; D006801:Humans; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D008954:Models, Biological; D011485:Protein Binding; D055503:Protein Multimerization
chemical_list: D002352:Carrier Proteins; C511240:DYNC1H1 protein, human; D000072159:Dynactin Complex; D008869:Microtubule-Associated Proteins; C421108:NDEL1 protein, human; D043203:1-Alkyl-2-acetylglycerophosphocholine Esterase; C084102:PAFAH1B1 protein, human; D056445:Cytoplasmic Dyneins