title: Antiplasmodial activity of bacilosarcin A isolated from the octocoral-associated bacterium Bacillus sp. collected in Panama.
abstract: OBJECTIVE
  This study was designed for isolating and characterizing antiplasmodial compounds from marine octocoral-associated bacteria.
  
  
  METHODS
  The organic extract of the Bacillus sp. was subjected to purification using several chromatography techniques guided by bioassays to yield three isocoumarin derivatives (1-3). Chemical structures of the compounds were elucidated on the basis of HRMS spectra and NMR spectroscopy. The antiplasmodial activity of the isolated compounds was evaluated in vitro against the chloroquine-resistant Plasmodium falciparum strain W2.
  
  
  RESULTS
  Isolated compounds were identified as bacilosarcin A (1), AI77-F (2), and AI77-H (3). Bacilosarcin A (1) displayed a low micromolar activity (IC(50) = 2.2 μM) against P. falciparum while compounds 2 and 3 showed no activity.
  
  
  CONCLUSIONS
  Bacilosarcin A was found to be responsible for the antiplasmodial activity observed in the crude extract obtained from the Bacillus sp.
authors.affiliation: Center for Drug Discovery, Institute for Scientific Research and Technology Services (INDICASAT), Clayton, City of Knowledge, Republic of Panama.
authors.forename: Cristopher A
authors.initials: CA
authors.lastname: Boya
authors.forename: Liuris
authors.initials: L
authors.lastname: Herrera
authors.forename: Hector M
authors.initials: HM
authors.lastname: Guzman
authors.forename: Marcelino
authors.initials: M
authors.lastname: Gutierrez