title: [Reduning injection for community-acquired pneumonia: meta-analysis].
abstract: OBJECTIVE
  To evaluate the efficacy and safety of Reduning injection for treating community-acquired pneumonia.
  
  
  METHODS
  Literatures about randomized controlled trials of Reduning injection for treating community-acquired pneumonia were reviewed. The methodological quality of the trials was assessed by the Jadad scale, and evaluation was performed.
  
  
  RESULTS
  Seven RCTS were included. Reduning combined group (Reduning injection plus antibiotics and basic therapy) was compared with antibiotics group (antibiotics plus basic therapy). Meta-analysis showed that the relative risk (RR) for the total cure rate was 1.34, and 95% confidence interval (CI) was [1.19, 1.51]; RR for the total effective rate was 1.10, and 95% CI was [1.06, 1.15]. The weighted mean difference (WMD) in disappearance time of fever between the two groups was - 1.42, and 95% CI was [- 2.58, -0.26]; The WMD between the two groups for the total obvious effect rate of cough and expectoration were - 2.36, and 95% CI was [- 3.41, - 1.31]; Improve the time of pulmonary rales MD -2.30, 95% CI [- 2.61, - 2.00]; The WMD between the two groups in absorption of chest x-ray shadow was -2.36 and 95% CI [-2.52, -2.20]. Serious systematic adverse reactions had not been reported in the trials.
  
  
  CONCLUSIONS
  The effect of combined therapy with Reduning injection plus antibiotics and basic therapy is better than that of antibiotics plus basic therapy. Reduning injection can improve the symptoms of cough and expectoration, shorten the fever time and facilitate the absorption of chest x-ray shadow without any significant adverse reactions. However, further high quality trials are needed.
authors.affiliation: Department of Emergency, Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300150, China.
authors.forename: Wanpeng
authors.initials: W
authors.lastname: Gao
authors.forename: Shiguang
authors.initials: S
authors.lastname: Wang
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Cui
authors.forename: Jie
authors.initials: J
authors.lastname: Cao
authors.forename: Hengyong
authors.initials: H
authors.lastname: Tian
mesh_terms: D017714:Community-Acquired Infections / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006801:Humans; D007267:Injections; D011014:Pneumonia / Q000188:drug therapy*
chemical_list: D004365:Drugs, Chinese Herbal