title: Low-density lipoprotein apheresis is effective in reducing lipoprotein(a) levels and in improving symptoms in a patient with refractory angina secondary to accelerated coronary artery disease.
abstract: Coronary artery disease remains a significant cause of morbidity and mortality in the Western world. High plasma Lp(a) concentrations are related to the risk of cardiovascular disease, but Lp(a) is rarely assayed and treated. We present the case of a 50-year-old gentleman with refractory angina, whose coronary disease continued to progress despite optimal medical and surgical therapy. We show that the aggressive reduction of Lp(a) successfully ameliorated the progression of coronary stenosis and provides effective and durable relief of symptoms.
authors.affiliation: Royal Brompton and Harefield Hospital NHS Foundation Trust, Hill End Road, London UB9 6JH, United Kingdom.
authors.forename: Michael
authors.initials: M
authors.lastname: Ibrahim
authors.forename: Bassey
authors.initials: B
authors.lastname: Ussen
authors.forename: Alison
authors.initials: A
authors.lastname: Pottle
authors.forename: Mahmoud
authors.initials: M
authors.lastname: Barbir
mesh_terms: D000787:Angina Pectoris / Q000097:blood* / Q000150:complications / Q000628:therapy*; D001781:Blood Component Removal; D003324:Coronary Artery Disease / Q000150:complications*; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood* / Q000302:isolation & purification*; D008077:Lipoproteins, LDL / Q000097:blood / Q000302:isolation & purification*; D008297:Male; D008875:Middle Aged
chemical_list: D017270:Lipoprotein(a); D008077:Lipoproteins, LDL