title: Bioactive secondary metabolites from marine microbes for drug discovery.
abstract: The isolation and extraction of novel bioactive secondary metabolites from marine microorganisms have a biomedical potential for future drug discovery as the oceans cover 70% of the planet's surface and life on earth originates from sea. Wide range of novel bioactive secondary metabolites exhibiting pharmacodynamic properties has been isolated from marine microorganisms and many to be discovered. The compounds isolated from marine organisms (macro and micro) are important in their natural form and also as templates for synthetic modifications for the treatments for variety of deadly to minor diseases. Many technical issues are yet to overcome before wide-scale bioprospecting of marine microorganisms becomes a reality. This chapter focuses on some novel secondary metabolites having antitumor, antivirus, enzyme inhibitor, and other bioactive properties identified and isolated from marine microorganisms including bacteria, actinomycetes, fungi, and cyanobacteria, which could serve as potentials for drug discovery after their clinical trials.
authors.affiliation: Department of Fisheries, Animal and Veterinary Science, University of Rhode Island, Kingston, RI, USA. chamilaninikapitiya@yahoo.com
authors.forename: Chamilani
authors.initials: C
authors.lastname: Nikapitiya
mesh_terms: D000190:Actinomyces / Q000254:growth & development / Q000302:isolation & purification / Q000378:metabolism; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D059001:Aquatic Organisms / Q000254:growth & development / Q000302:isolation & purification / Q000378:metabolism* / Q000382:microbiology; D000458:Cyanobacteria / Q000254:growth & development / Q000302:isolation & purification / Q000378:metabolism; D055808:Drug Discovery; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D005658:Fungi / Q000254:growth & development / Q000302:isolation & purification / Q000378:metabolism*; D006090:Gram-Negative Bacteria / Q000254:growth & development / Q000302:isolation & purification / Q000378:metabolism*; D006094:Gram-Positive Bacteria / Q000254:growth & development / Q000302:isolation & purification / Q000378:metabolism*; D006801:Humans; D055442:Metabolome; D013559:Symbiosis
chemical_list: D000903:Antibiotics, Antineoplastic; D000998:Antiviral Agents; D004791:Enzyme Inhibitors