title: Scaffold hybridization in generation of indenoindolones as anticancer agents that induce apoptosis with cell cycle arrest at G2/M phase.
abstract: Scaffold hybridization of several natural and synthetic anticancer leads led to the consideration of indenoindolones as potential novel anticancer agents. A series of these compounds were prepared by a diversity-feasible synthetic method. They were found to possess anticancer activities with higher potency compared to etoposide and 5-fluorouracil in kidney cancer cells (HEK 293) and low toxicity to corresponding normal cells (Vero). They exerted apoptotic effect with blocking of cell cycle at G2/M phase.
authors.affiliation: National Institute of Pharmaceutical Education and Research, Sector 67, SAS Nagar, Mohali, Punjab 160062, India.
authors.forename: Maneesh
authors.initials: M
authors.lastname: Kashyap
authors.forename: Dipon
authors.initials: D
authors.lastname: Das
authors.forename: Ranjan
authors.initials: R
authors.lastname: Preet
authors.forename: Purusottam
authors.initials: P
authors.lastname: Mohapatra
authors.forename: Shakti Ranjan
authors.initials: SR
authors.lastname: Satapathy
authors.forename: Sumit
authors.initials: S
authors.lastname: Siddharth
authors.forename: Chanakya N
authors.initials: CN
authors.lastname: Kundu
authors.forename: Sankar K
authors.initials: SK
authors.lastname: Guchhait
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects*; D015415:Biomarkers / Q000378:metabolism; D002470:Cell Survival / Q000187:drug effects; D002522:Chlorocebus aethiops; D005047:Etoposide / Q000494:pharmacology; D005434:Flow Cytometry; D005472:Fluorouracil / Q000494:pharmacology; D059565:G2 Phase Cell Cycle Checkpoints / Q000187:drug effects*; D057809:HEK293 Cells; D006801:Humans; D007192:Indenes / Q000138:chemical synthesis* / Q000494:pharmacology; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D014709:Vero Cells
chemical_list: D000970:Antineoplastic Agents; D015415:Biomarkers; D007192:Indenes; D007211:Indoles; D005047:Etoposide; D005472:Fluorouracil