title: Design, synthesis, in vitro antimicrobial and anticancer activity of novel methylenebis-isoxazolo[4,5-b]azepines derivatives.
abstract: A series of novel methylene bis-isoxazolo[4,5-b]azepines have been synthesized by reaction of 3,5-dimethyl-4-nitroisoxazole 6 with an appropriate methylene bis-chalcones 7 to obtain various Michael adducts 8a-i, which on treatment with SnCl(2)-MeOH underwent reductive cyclization to afford the title compounds 9a-i. Structure of these compounds were established on the basis of IR, (1)H NMR, (13)C NMR and mass spectral data. The title compounds 9a-i were evaluated for their in vitro antimicrobial and anticancer activities. Compounds 9h and 9i exhibited potent antimicrobial and anticancer activities as that of standard drugs.
authors.affiliation: Department of Chemistry, Kakatiya University, Warangal 506 009, A.P., India. eligeti_rajan@yahoo.co.in
authors.forename: E
authors.initials: E
authors.lastname: Rajanarendar
authors.forename: M
authors.initials: M
authors.lastname: Nagi Reddy
authors.forename: S
authors.initials: S
authors.lastname: Rama Krishna
authors.forename: K
authors.initials: K
authors.lastname: Govardhan Reddy
authors.forename: Y N
authors.initials: YN
authors.lastname: Reddy
authors.forename: M V
authors.initials: MV
authors.lastname: Rajam
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001381:Azepines / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D001943:Breast Neoplasms / Q000188:drug therapy*; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D015195:Drug Design; D005260:Female; D006801:Humans; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D007668:Kidney / Q000166:cytology / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D001381:Azepines; D007555:Isoxazoles; C573635:methylenebis(7,8-dihydro-6H-3-methyl-5-(2-furyl)-7-(2-hydroxyphenyl)isoxazolo(4,5-b)azepine); C573636:methylenebis(7,8-dihydro-6H-3-methyl-5-(2-thienyl)-7-(2-hydroxyphenyl)isoxazolo(4,5-b)azepine)