title: Carcinosarcoma of the gallbladder: report of two cases.
abstract: Adenocarcinoma is the predominant histological type of carcinoma of the gallbladder, accounting for more than 80% of all gallbladder carcinomas. In contrast, carcinosarcoma of the gallbladder is an extremely atypical subset of gallbladder malignancies. It is characterized by the presence of both epithelial and mesenchymal components. Currently, fewer than 100 cases have been reported in the English literature. Therefore, knowledge and experience regarding this disease are limited. Recently, we experienced two cases of gallbladder carcinosarcoma, which were diagnosed as gallbladder carcinoma based on the preoperative clinical and radiological examinations. Cholecystectomies were performed in both cases, and the malignant tumor cells included carcinomatous and sarcomatous components histologically. The final pathological diagnoses were carcinosarcoma of the gallbladder. We herein report these two cases of gallbladder carcinosarcoma and review the previous pertinent literature.
authors.affiliation: Department of Surgery, Chonnam National University Medical School, 160, Ilsim-ri, Hwasun-eup, Hwasun-gun, Jellanam-do, Gwangju, 519-809, Korea.
authors.forename: Ho-Hyun
authors.initials: HH
authors.lastname: Kim
authors.forename: Young-Hoe
authors.initials: YH
authors.lastname: Hur
authors.forename: Eun-Hui
authors.initials: EH
authors.lastname: Jeong
authors.forename: Eun-Kyu
authors.initials: EK
authors.lastname: Park
authors.forename: Yang-Seok
authors.initials: YS
authors.lastname: Koh
authors.forename: Jung-Chul
authors.initials: JC
authors.lastname: Kim
authors.forename: Hyun-Jong
authors.initials: HJ
authors.lastname: Kim
authors.forename: Jin-Woong
authors.initials: JW
authors.lastname: Kim
authors.forename: Chol Kyoon
authors.initials: CK
authors.lastname: Cho
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002296:Carcinosarcoma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D002763:Cholecystectomy; D005260:Female; D005706:Gallbladder Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000473:pathology / Q000601:surgery; D008197:Lymph Node Excision; D008297:Male; D009361:Neoplasm Invasiveness