title: Interregional correlations in Parkinson disease and Parkinson-related dementia with resting functional MR imaging.
abstract: OBJECTIVE
  To apply a recently developed native-space (or native-surface) method to compare resting functional magnetic resonance (MR) imaging correlations (functional connectivity) measured in patients with Parkinson-related dementia (PRD) to those measured in cognitively unimpaired, age-matched control subjects with or without Parkinson disease (PD).
  
  
  METHODS
  The study was approved by the institutional review board and complied with HIPAA regulations. Participants included cognitively unimpaired elderly individuals (n = 19), cognitively unimpaired patients with PD (n = 19), and patients with PRD (n = 18). Resting functional MR data were assessed by calculating correlation coefficients between blood oxygen level-dependent time series of a seed region and of other regions of interest selected a priori. Two seeds were used: a medial parietal region that contributes to the default network affected in Alzheimer disease and the caudate, which is affected by loss of dopaminergic inputs in PD. Correlation analyses were performed in the native space of individual subjects to avoid confounds from transformation to an average brain. Two-sample t tests were applied to data from each native-surface region of interest, and vertex-wise comparisons were made by using two-sample t tests at each vertex on the group surface; statistical results were corrected for multiple comparisons. Cortical thickness and striatal volumes were also compared across groups for the regions of interest.
  
  
  RESULTS
  Corticostriatal functional correlations were decreased in PRD patients relative to elderly control subjects in bilateral prefrontal regions; largest difference was observed in the right caudal middle frontal region (r = 0.48 in PRD patients and 0.81 in elderly control subjects, uncorrected P = .001). Conversely, there was no significant difference across groups in the strength of default-network correlations. There was also no significant difference across groups in cortical thickness or striatal volume.
  
  
  CONCLUSIONS
  PRD was associated with selective disruption of corticostriatal resting functional MR imaging correlations, which suggests that resting functional MR imaging analyzed in subject-native space may be a useful biomarker in this disease. Additionally, at least in the present cohort, this technique was more sensitive to PRD changes than was quantitative structural MR imaging.
authors.affiliation: Department of Bioengineering, University of California, San Diego, La Jolla, CA 92093-0949, USA.
authors.forename: Tyler M
authors.initials: TM
authors.lastname: Seibert
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Murphy
authors.forename: Erik J
authors.initials: EJ
authors.lastname: Kaestner
authors.forename: James B
authors.initials: JB
authors.lastname: Brewer
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D016022:Case-Control Studies; D003704:Dementia / Q000209:etiology / Q000473:pathology*; D005260:Female; D006801:Humans; D007090:Image Interpretation, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D010300:Parkinson Disease / Q000150:complications / Q000473:pathology*; D011446:Prospective Studies