title: Lack of association between interleukin-18 -607 C/A gene polymorphism and pulmonary tuberculosis in Zahedan, Southeast Iran.
abstract: Interleukin-18 (IL-18) plays a critical role in immune response,             contributing to the pathogenesis and pathophysiology of infectious diseases.             Polymorphisms in the IL-18 genes are known to influence expression levels and             may be associated with outcome of infections. The objective of this study was to             determine whether the presence of IL-18 polymorphisms -607 A/C (rs1946518)             was associated with tuberculosis disease. We investigated the functional             polymorphism of IL-18 (rs1946518) in 174 patients with pulmonary tuberculosis             (PTB) and 177 healthy subjects. Genotype analysis was done using tetra amplification             refractory mutation system-PCR (T-ARMS-PCR). The allelic and genotypic             frequencies of the IL-18 polymorphism did not differ significantly between PTB and             the controls. Our finding suggests that IL-18 polymorphism (rs1946518) may not             be a risk factor for susceptibility to tuberculosis in a sample of Iranian population.             Further studies are required to validate our findings.
authors.affiliation: Cellular and Molecular Research Center, Zahedan University of Medical Sciences, Zahedan, Iran.
authors.forename: M
authors.initials: M
authors.lastname: Taheri
authors.forename: S M
authors.initials: SM
authors.lastname: Hashemi-Shahri
authors.forename: M
authors.initials: M
authors.lastname: Hamzehnejadi
authors.forename: M
authors.initials: M
authors.lastname: Naderi
authors.forename: A
authors.initials: A
authors.lastname: Moazeni-Roodi
authors.forename: G
authors.initials: G
authors.lastname: Bahari
authors.forename: M
authors.initials: M
authors.lastname: Hashemi
mesh_terms: D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D020382:Interleukin-18 / Q000235:genetics*; D007492:Iran; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D014397:Tuberculosis, Pulmonary / Q000235:genetics*
chemical_list: D020382:Interleukin-18