title: Genetic polymorphisms in oxidative stress pathway genes and modification of BMI and risk of non-Hodgkin lymphoma.
abstract: BACKGROUND
  Being overweight and obese increases oxidative stress in the body. To test the hypothesis that genetic variations in oxidative stress pathway genes modify the relationship between body mass index (BMI) and risk of non-Hodgkin lymphoma (NHL), we conducted a population-based case-control study in Connecticut women.
  
  
  METHODS
  Individuals who were overweight/obese (BMI ≥ 25) were compared with normal and underweight individuals (BMI < 25), and their risk of NHL stratified assuming a dominant allele model for each oxidative stress pathway single-nucleotide polymorphism.
  
  
  RESULTS
  Polymorphisms in AKR1A1, AKR1C1, AKR1C3, CYBA, GPX1, MPO, NCF2, NCF4, NOS1, NOS2A NOS3, OGG1, ATG9B, SOD1, SOD2, SOD3, RAC1, and RAC2 genes after false discovery rate adjustment did not modify the association between BMI and risk of NHL overall and histologic subtypes.
  
  
  CONCLUSIONS
  The results suggest that common genetic variations in oxidative stress genes do not modify the relationship between BMI and risk of NHL.
  
  
  CONCLUSIONS
  Studies of BMI and oxidative stress independently may elevate NHL risk, but this study suggests no interaction of the two risk factors. Future studies with larger study populations may reveal interactions.
authors.affiliation: Yale University School of Public Health, New Haven, CT 06520, USA.
authors.forename: Christopher
authors.initials: C
authors.lastname: Kim
authors.forename: Tongzhang
authors.initials: T
authors.lastname: Zheng
authors.forename: Qing
authors.initials: Q
authors.lastname: Lan
authors.forename: Yingtai
authors.initials: Y
authors.lastname: Chen
authors.forename: Francine
authors.initials: F
authors.lastname: Foss
authors.forename: Xuezhong
authors.initials: X
authors.lastname: Chen
authors.forename: Theodore
authors.initials: T
authors.lastname: Holford
authors.forename: Brian
authors.initials: B
authors.lastname: Leaderer
authors.forename: Peter
authors.initials: P
authors.lastname: Boyle
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Chanock
authors.forename: Nathaniel
authors.initials: N
authors.lastname: Rothman
authors.forename: Yawei
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000368:Aged; D015992:Body Mass Index; D016022:Case-Control Studies; D003237:Connecticut / Q000453:epidemiology; D005260:Female; D005838:Genotype; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D008875:Middle Aged; D009765:Obesity / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D018384:Oxidative Stress / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors