title: Genetic variants on 17q21 are associated with asthma  in a Han Chinese population.
abstract: A genome-wide study has shown an association between  SNPs located on 17q21 and asthma. Such associations have been identified in  several populations, but little is known about the Han Chinese population. We  conducted a case-control study in a Han Chinese population to investigate the  relationship between SNPs located on 17q21 and asthma; 241 asthmatic patients  and 212 healthy controls were recruited from the outpatient clinics of the  Nanfang Hospital, Guangdong Province, southern China. We genotyped six SNPs  (rs8067378, rs8069176, rs2305480, rs4795400, rs12603332, and rs11650680)  located on 17q21 with the Sequenom MassARRAY iPLEX platform. For two of these  six loci (rs2305480 and rs8067378), there was evidence of association with  asthma, and there was a weak association of asthma with rs8069176. We confirm  that genetic variants on 17q21 are associated with asthma in the Han Chinese  population.
authors.affiliation: School of Biotechnology, Southern Medical University, Guangzhou, PR China.
authors.forename: F-X
authors.initials: FX
authors.lastname: Li
authors.forename: J-Y
authors.initials: JY
authors.lastname: Tan
authors.forename: X-X
authors.initials: XX
authors.lastname: Yang
authors.forename: Y-S
authors.initials: YS
authors.lastname: Wu
authors.forename: D
authors.initials: D
authors.lastname: Wu
authors.forename: M
authors.initials: M
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001249:Asthma / Q000235:genetics* / Q000473:pathology; D016022:Case-Control Studies; D002648:Child; D002681:China / Q000208:ethnology; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult; D000094524:Gasdermins
chemical_list: D009363:Neoplasm Proteins; C527978:GSDMB protein, human; D000094524:Gasdermins