title: Intravascular large B-cell lymphoma.
abstract: A rare type of diffuse large B-cell lymphoma, intravascular large B-cell lymphoma primarily affects the middle-aged to elderly population, with a slight predominance in men. By the time of presentation, most patients have advanced, disseminated disease, and often the diagnosis is made at autopsy. Patients may present with any of a myriad of symptoms, with any tissue potentially being infiltrated. Central nervous system and cutaneous involvement is common, as is the presence of B symptoms including fever, weight loss, and night sweats. Morphologically, growth of neoplastic cells is restricted to the lumen of small vessels. The cells are large, with 1 or more prominent nucleoli, scant cytoplasm, and frequent mitotic figures, and are commonly positive for cluster of differentiation markers 79a, 20, and 19, as well as MUM1/IRF4 and Bcl-2. Intravascular large B-cell lymphoma is aggressive, and without treatment is rapidly fatal.
authors.affiliation: Department of Pathology, Medical University of South Carolina, Charleston, 29425, USA.
authors.forename: Dennis E
authors.initials: DE
authors.lastname: Orwat
authors.forename: Nicholas I
authors.initials: NI
authors.lastname: Batalis
mesh_terms: D000368:Aged; D018951:Antigens, CD20 / Q000032:analysis; D002490:Central Nervous System / Q000737:chemistry / Q000473:pathology*; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy; D008297:Male; D012867:Skin / Q000737:chemistry / Q000473:pathology*; D019043:Vascular Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000628:therapy
chemical_list: D018951:Antigens, CD20