title: Investigation of basement membrane proteins in a case of granular cell ameloblastoma.
abstract: Granular cell ameloblastoma is a rare, benign neoplasm of the odontogenic epithelium. A case of massive granular cell ameloblastoma in a 44-year-old Thai female is reported. Histopathological features displayed a follicular type of ameloblastoma with an accumulation of granular cells residing within the tumor follicles. After treatment by partial mandibulectomy, the patient showed a good prognosis without recurrence in a 2-year follow-up. To characterize the granular cells in ameloblastoma, we examined the expression of basement membrane (BM) proteins, including collagen type IV, laminins 1 and 5 and fibronectin using immunohistochemistry. Except for the granular cells, the tumor cells demonstrated a similar expression of BM proteins compared to follicular and plexiform ameloblastomas in our previous study, whereas the granular cells showed strong positivity to laminins 1 and 5 and fibronectin. The increased fibronectin expression in granular cells suggests a possibility of age-related transformation of granular cells in ameloblastoma.
authors.affiliation: Department of Oral and Maxillofacial Pathology, Mahidol University, Bangkok, Thailand.
authors.forename: Puangwan
authors.initials: P
authors.lastname: Lapthanasupkul
authors.forename: Sopee
authors.initials: S
authors.lastname: Poomsawat
authors.forename: Jira
authors.initials: J
authors.lastname: Chindasombatjaroen
mesh_terms: D000328:Adult; D000564:Ameloblastoma / Q000737:chemistry* / Q000473:pathology; D001485:Basement Membrane / Q000737:chemistry*; D015815:Cell Adhesion Molecules / Q000032:analysis; D024141:Collagen Type IV / Q000032:analysis; D005260:Female; D005353:Fibronectins / Q000032:analysis; D006801:Humans; D015603:Keratinocytes / Q000737:chemistry / Q000473:pathology; D007797:Laminin / Q000032:analysis; D008339:Mandibular Neoplasms / Q000737:chemistry* / Q000473:pathology; D008565:Membrane Proteins / Q000032:analysis*; D000097794:Kalinin
chemical_list: D015815:Cell Adhesion Molecules; D024141:Collagen Type IV; D005353:Fibronectins; D007797:Laminin; D008565:Membrane Proteins; D000097794:Kalinin; C121346:laminin 1