title: GluA and GluN receptors regulate the surface density of GluN receptor subunits in cultured neocortical interneurons.
abstract: J. Neurochem. (2012) 121, 597-606.
  In cultured rat neocortical interneurons, we have studied the effect of long-term application of NMDA or AMPA on the surface density of the NMDA (GluN) receptor subunits GluN1 and GluN2B. Stimulation of Ca(2+) -permeable AMPA (GluA) receptors located on the interneurons decreased the response of GluN receptors. The reduction was caused by a decrease in the surface density of GluN1/GluN2B subunits. In contrast, stimulation of GluN receptors located on the interneurons enhanced the surface density of GluN1/GluN2B subunits. Both effects could be induced by network activation.
authors.affiliation: Department of Experimental and Clinical Pharmacology and Toxicology, Albert-Ludwigs-University, Freiburg, Germany. dieter.meyer@pharmakol.uni-freiburg.de
authors.forename: Dieter K
authors.initials: DK
authors.lastname: Meyer
authors.forename: A Kerstin
authors.initials: AK
authors.lastname: Lindemeyer
authors.forename: Thomas
authors.initials: T
authors.lastname: Wilmes
authors.forename: Helga
authors.initials: H
authors.lastname: Sobottka
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Nörenberg
mesh_terms: D000465:Algorithms; D000818:Animals; D019921:Biotinylation; D020013:Calcium Signaling / Q000187:drug effects; D002478:Cells, Cultured; D015536:Down-Regulation / Q000187:drug effects / Q000502:physiology; D055724:Electrophysiological Phenomena; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology; D007150:Immunohistochemistry; D007395:Interneurons / Q000187:drug effects / Q000502:physiology*; D016202:N-Methylaspartate / Q000494:pharmacology; D019579:Neocortex / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D009415:Nerve Net / Q000166:cytology / Q000502:physiology; D018408:Patch-Clamp Techniques; D051381:Rats; D017208:Rats, Wistar; D018091:Receptors, AMPA / Q000187:drug effects / Q000502:physiology*; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000502:physiology; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects / Q000502:physiology*; D013779:Tetrodotoxin / Q000494:pharmacology; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid / Q000494:pharmacology
chemical_list: D018690:Excitatory Amino Acid Agonists; D018091:Receptors, AMPA; D011956:Receptors, Cell Surface; D016194:Receptors, N-Methyl-D-Aspartate; D013779:Tetrodotoxin; D016202:N-Methylaspartate; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid