title: [Study on the correlation between stroke of qi deficiency syndrome and the neurological impairment degree and its long-term prognosis].
abstract: OBJECTIVE
  To explore the correlation between stroke of qi deficiency syndrome (QDS) and the neurological impairment degree, and to study its correlation between QDS and its long-term prognosis.
  
  
  METHODS
  Recruited were 706 stroke patients with complete clinical information including diagnostic scale scoring of elements such as wind, fire, phlegm, blood stasis, qi deficiency, and yin deficiency, scoring of The National Institutes of Health Stroke Scale (NIHSS) within 72 h from attack, on the 7th, 14th, 28th, and 90th day after attack, and Barthel index (BI) scoring on the 90th day. They were assigned to the QDS group (330 cases) and the non-QDS group (376 cases). The NIHSS scores at different time points were compared between the two groups using analysis of variance of repeated measure data. The correlation between each syndrome element and the long-term prognosis of stroke was studied using Logistic regression analysis.
  
  
  RESULTS
  Higher NIHSS score was found in patients of QDS than those of non-QDS at each time point (P < 0.01). Statistical difference existed in NIHSS score between the two groups at each time point (P < 0.01, P < 0.05). Besides, NIHSS score decreased gradually as time went by. The occurrence frequencies of blood stasis syndrome and phlegm syndrome were higher at each time point. On the 90th day after attack, 427 patients with BI > or = 95 (accounting for 60%) had favorable prognosis, while 279 with BI < 95 (accounting for 40%) had unfavorable prognosis. QDS at each time point was negatively correlated with the 90th-day BI, with the B value being -0.496, -0.714, -0.867, -0.567, and -0.764, respectively.
  
  
  CONCLUSIONS
  Stroke patients of QDS had more severe neurological impairment than those of non-QDS. Stroke patients of acute-stage QDS was closely correlated with unfavorable prognosis on the 90th day after attack. Early actively invigorating healthy qi plays an important role in improving the long-term prognosis of stroke patients.
authors.affiliation: Department of Neurology, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing.
authors.forename: Xi-yan
authors.initials: XY
authors.lastname: Xin
authors.forename: Ying
authors.initials: Y
authors.lastname: Gao
authors.forename: Bin
authors.initials: B
authors.lastname: Ma
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D009420:Nervous System / Q000503:physiopathology; D011379:Prognosis; D019413:Qi; D020521:Stroke / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology*; D016710:Yin Deficiency