title: [Analysis of chemical composition of sini san by ultra performance liquid chromatography-electrospray ionization-mass spectrometry].
abstract: OBJECTIVE
  To analyze and identify the chemical ingredients in Sini San by LC-MS.
  
  
  METHODS
  These compounds were analyzed with an ACQUITY UPLC BEH C18 (2.1 mm x 100 mm, 1.7 microm) by gradient elution of methyl cyanides and 0.1% formic acid. ESI source was used and data were collected in positive and negative mode.
  
  
  RESULTS
  Seventeen compounds of Sini San were identified by direct comparison in both positive and negative modes of Q-TOF-MS, the elemental compositions analysis, the standard substance and the data of the literature.
  
  
  CONCLUSIONS
  It is a rapid and accurate method that the composition of compound prescription of traditional Chinese medicine can be identified in terms of the separation of ultra high performance liquid chromatography, the accurate molecurlar weights measured by MS and other information, which can trace to the source of compounds in Sinisan.
authors.affiliation: Nanjing University of Chinese Medicine, Nanjing 210046, China. guorong550426@163.com
authors.forename: Rong
authors.initials: R
authors.lastname: Guo
authors.forename: Yan
authors.initials: Y
authors.lastname: Shu
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Yudan
authors.initials: Y
authors.lastname: Cao
authors.forename: Anwei
authors.initials: A
authors.lastname: Ding
authors.forename: Weifeng
authors.initials: W
authors.lastname: Yao
mesh_terms: D002853:Chromatography, Liquid / Q000379:methods*; D008516:Medicine, Chinese Traditional; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*