title: Olive oil intake and breast cancer risk in the Mediterranean countries of the European Prospective Investigation into Cancer and Nutrition study.
abstract: Although there is some evidence suggesting that olive oil could reduce breast cancer (BC) risk, the epidemiological data are still relatively limited, not entirely consistent and mainly based on case-control studies. Therefore, we prospectively assessed the association between olive oil and BC risk in postmenopausal women from the Mediterranean cohorts within the European Prospective Investigation into Cancer and Nutrition. The analysis included 62,284 postmenopausal women recruited from Spain, Italy and Greece who had complete dietary data (collected from validated country-specific dietary questionnaires). The risk of BC (overall and by hormone receptor subtypes) was assessed using hazards ratios (HRs) obtained from Cox proportional hazards regression, while adjusting for known BC risk factors. After a mean follow-up of 9 years, 1,256 women were diagnosed with a primary incident invasive BC. The multivariate HRs for BC risk by olive oil intake (highest vs. lowest tertile of g/day/2,000 kcal) were 1.07 (95% CI = 0.91-1.25) in the adjusted model, 1.06 (95% CI = 0.91-1.24) in the model additionally adjusted for reproductive-related factors and 1.10 (95% CI = 0.92-1.31) for the model additionally adjusted for dietary factors. There was no association between olive oil and risk of estrogen or progesterone receptor-positive tumors, but a suggestion of a negative association with estrogens and progesterone receptor-negative tumors. The results from our prospective study showed that olive oil consumption during adult life was not associated with the risk of BC. However, larger prospective studies are still needed to explore possible differences related to hormone receptor status.
authors.affiliation: Unit of Nutrition, Environment and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO-IDIBELL), Barcelona, Spain. gbuckland@iconcologia.net
authors.forename: Genevieve
authors.initials: G
authors.lastname: Buckland
authors.forename: Noemie
authors.initials: N
authors.lastname: Travier
authors.forename: Antonio
authors.initials: A
authors.lastname: Agudo
authors.forename: Ana
authors.initials: A
authors.lastname: Fonseca-Nunes
authors.forename: Carmen
authors.initials: C
authors.lastname: Navarro
authors.forename: Pagona
authors.initials: P
authors.lastname: Lagiou
authors.forename: Christiana
authors.initials: C
authors.lastname: Demetriou
authors.forename: Pilar
authors.initials: P
authors.lastname: Amiano
authors.forename: Miren
authors.initials: M
authors.lastname: Dorronsoro
authors.forename: María-Dolores
authors.initials: MD
authors.lastname: Chirlaque
authors.forename: José-María
authors.initials: JM
authors.lastname: Huerta
authors.forename: Esther
authors.initials: E
authors.lastname: Molina
authors.forename: Maria-José Sánchez
authors.initials: MJ
authors.lastname: Pérez
authors.forename: Eva
authors.initials: E
authors.lastname: Ardanaz
authors.forename: Conchi
authors.initials: C
authors.lastname: Moreno-Iribas
authors.forename: J Ramón
authors.initials: JR
authors.lastname: Quirós
authors.forename: Androniki
authors.initials: A
authors.lastname: Naska
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Trichopoulos
authors.forename: Maria Concetta
authors.initials: MC
authors.lastname: Giurdanella
authors.forename: Rosario
authors.initials: R
authors.lastname: Tumino
authors.forename: Claudia
authors.initials: C
authors.lastname: Agnoli
authors.forename: Sara
authors.initials: S
authors.lastname: Grioni
authors.forename: Salvatore
authors.initials: S
authors.lastname: Panico
authors.forename: Amalia
authors.initials: A
authors.lastname: Mattiello
authors.forename: Giovanna
authors.initials: G
authors.lastname: Masala
authors.forename: Carlotta
authors.initials: C
authors.lastname: Sacerdote
authors.forename: Silvia
authors.initials: S
authors.lastname: Polidoro
authors.forename: Domenico
authors.initials: D
authors.lastname: Palli
authors.forename: Antonia
authors.initials: A
authors.lastname: Trichopoulou
authors.forename: Carlos A
authors.initials: CA
authors.lastname: González
mesh_terms: D001943:Breast Neoplasms / Q000453:epidemiology* / Q000209:etiology; D015331:Cohort Studies; D004032:Diet; D005260:Female; D006801:Humans; D019083:Mediterranean Region / Q000453:epidemiology; D000069463:Olive Oil; D010938:Plant Oils; D017698:Postmenopause; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D012306:Risk
chemical_list: D000069463:Olive Oil; D010938:Plant Oils; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone