title: DevR (DosR) binding peptide inhibits adaptation of Mycobacterium tuberculosis under hypoxia.
abstract: DevR is a key regulator of the dormancy response in Mycobacterium tuberculosis (M. tb). Using DevR as bait to screen a phage display library, a peptide, DevRS1, was obtained. DevRS1 inhibited DevR-regulated transcription and survival of nonreplicating tubercle bacilli in a hypoxia model of dormancy. DevRS1 peptide-mediated inhibition demonstrates the efficacy of intercepting DevR function to block hypoxic adaptation of M. tb.
authors.affiliation: Department of Biotechnology, All India Institute of Medical Sciences, New Delhi, India.
authors.forename: Sakshi
authors.initials: S
authors.lastname: Dhingra
authors.forename: Kohinoor
authors.initials: K
authors.lastname: Kaur
authors.forename: Neetu K
authors.initials: NK
authors.lastname: Taneja
authors.forename: Jaya S
authors.initials: JS
authors.lastname: Tyagi
mesh_terms: D000222:Adaptation, Physiological; D000693:Anaerobiosis; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000378:metabolism*; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors*; D004268:DNA-Binding Proteins; D020869:Gene Expression Profiling; D015964:Gene Expression Regulation, Bacterial; D006801:Humans; D050296:Microbial Viability / Q000187:drug effects; D009169:Mycobacterium tuberculosis / Q000502:physiology*; D019151:Peptide Library; D010455:Peptides / Q000302:isolation & purification / Q000378:metabolism*; D011494:Protein Kinases; D013312:Stress, Physiological
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; C542863:DosR protein, Mycobacterium tuberculosis; D019151:Peptide Library; D010455:Peptides; D011494:Protein Kinases