title: Controlled drug delivery through a novel PEG hydrogel encapsulated silica aerogel system.
abstract: A novel composite material consisting of a silica aerogel core coated by a poly(ethylene) glycol (PEG) hydrogel was developed. The potential of this novel composite as a drug delivery system was tested with ketoprofen as a model drug due to its solubility in supercritical carbon dioxide. The results indicated that both drug loading capacity and drug release profiles could be tuned by changing hydrophobicity of aerogels, and that drug loading capacity increased with decreased hydrophobicity, while slower release rates were achieved with increased hydrophobicity. Furthermore, higher concentration of PEG diacrylate in the prepolymer solution of the hydrogel coating delayed the release of the drug which can be attributed to the lower permeability at higher PEG diacrylate concentrations. The novel composite developed in this study can be easily implemented to achieve the controlled delivery of various drugs and/or proteins for specific applications.
authors.affiliation: Department of Chemical and Biological Engineering, Koc University, Istanbul, Turkey.
authors.forename: Seda
authors.initials: S
authors.lastname: Giray
authors.forename: Tuğba
authors.initials: T
authors.lastname: Bal
authors.forename: Ayse M
authors.initials: AM
authors.lastname: Kartal
authors.forename: Seda
authors.initials: S
authors.lastname: Kızılel
authors.forename: Can
authors.initials: C
authors.lastname: Erkey
mesh_terms: D000327:Adsorption / Q000187:drug effects; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003692:Delayed-Action Preparations; D004058:Diffusion / Q000187:drug effects; D004801:Eosine Yellowish-(YS); D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions / Q000187:drug effects; D007660:Ketoprofen / Q000737:chemistry / Q000494:pharmacology*; D011092:Polyethylene Glycols / Q000737:chemistry*; D016062:Porosity / Q000187:drug effects; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D003692:Delayed-Action Preparations; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011092:Polyethylene Glycols; D012822:Silicon Dioxide; D007660:Ketoprofen; D004801:Eosine Yellowish-(YS)