title: The effect of multidisciplinary lifestyle intervention on the pre- and postprandial plasma gut Peptide concentrations in children with obesity.
abstract: Objective. This study aims to evaluate the effect of a multidisciplinary treatment of obesity on plasma concentrations of several gut hormones in fasting condition and in response to a mixed meal in children. Methods. Complete data were available from 36 obese children (age 13.3 ± 2.0 yr). At baseline and after the 3-month multidisciplinary treatment, fasting and postprandial blood samples were taken for glucose, insulin, ghrelin, peptide YY (PYY), and glucagon-like peptide 1 (GLP-1). Results. BMI-SDS was significantly reduced by multidisciplinary treatment (from 4.2 ± 0.7 to 4.0 ± 0.9, P < .01). The intervention significantly increased the area under the curve (AUC) of ghrelin (from 92.3 ± 18.3 to 97.9 ± 18.2 pg/L, P < .01), but no significant changes were found for PYY or GLP-1 concentrations (in fasting or postprandial condition). The insulin resistance index (HOMA-IR) remained unchanged as well. Conclusion. Intensive multidisciplinary treatment induced moderate weight loss and increased ghrelin secretion, but serum PYY and GLP-1 concentrations and insulin sensitivity remained unchanged.
authors.affiliation: Department of Pediatrics, Juliana Children's Hospital/Haga Hospital, Sportlaan 600, 2566 MJ the Hague, The Netherlands.
authors.forename: Rimke C
authors.initials: RC
authors.lastname: Vos
authors.forename: Hanno
authors.initials: H
authors.lastname: Pijl
authors.forename: Jan M
authors.initials: JM
authors.lastname: Wit
authors.forename: Erik W
authors.initials: EW
authors.lastname: van Zwet
authors.forename: Chris
authors.initials: C
authors.lastname: van der Bent
authors.forename: Euphemia C A M
authors.initials: EC
authors.lastname: Houdijk