title: HOMA-IR and non-HDL-C as predictors of high cholesteryl ester transfer protein activity in patients at risk for type 2 diabetes.
abstract: OBJECTIVE
  Metabolic syndrome (MS) and type 2 diabetes are highly associated with an abnormal lipoprotein profile, which may be generated and accentuated by high cholesteryl ester transfer protein (CETP) activity. Given the difficulty in measuring CETP activity, the aim was to identify simple biochemical predictors of high CETP activity.
  
  
  METHODS
  Eighty five subjects at risk for type 2 diabetes were classified according to the presence of MS. Lipoprotein profile, HOMA-IR and endogenous CETP activity were evaluated.
  
  
  RESULTS
  As expected, MS patients presented higher concentration of glucose, insulin, triglycerides and non-HDL-C and lower HDL-C levels. Moreover, MS patients exhibited increased HOMA-IR and CETP activity. Employing a ROC curve for MS, high CETP activity was defined as >250%ml⁻¹ h⁻¹. The predictive variables of high CETP were non-HDL-C≥160mg/dl (OR=11.1;95%IC=3.3-38.2;p<0.001) and HOMA-IR>2.1 (OR=4.4;95%IC=1.3-14.8;p<0.05).
  
  
  CONCLUSIONS
  High non-HDL-C and insulin resistance were predictors for increased CETP activity which measurement is not accessible for clinical laboratories.
authors.affiliation: Integral Clinical Biochemistry Institute, Viedma, Argentina.
authors.forename: R I
authors.initials: RI
authors.lastname: Coniglio
authors.forename: T
authors.initials: T
authors.lastname: Meroño
authors.forename: H
authors.initials: H
authors.lastname: Montiel
authors.forename: M M
authors.initials: MM
authors.lastname: Malaspina
authors.forename: A M
authors.initials: AM
authors.lastname: Salgueiro
authors.forename: J C
authors.initials: JC
authors.lastname: Otero
authors.forename: R
authors.initials: R
authors.lastname: Ferraris
authors.forename: L
authors.initials: L
authors.lastname: Schreier
authors.forename: F
authors.initials: F
authors.lastname: Brites
authors.forename: L
authors.initials: L
authors.lastname: Gómez Rosso
mesh_terms: D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D001786:Blood Glucose; D015992:Body Mass Index; D016022:Case-Control Studies; D053480:Cholesterol Ester Transfer Proteins / Q000097:blood / Q000378:metabolism*; D008076:Cholesterol, HDL / Q000097:blood* / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D016014:Linear Models; D008297:Male; D024821:Metabolic Syndrome / Q000378:metabolism / Q000473:pathology; D008875:Middle Aged; D012307:Risk Factors; D055105:Waist Circumference
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; C506642:CETP protein, human; D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL