title: Leptin and peroxisome proliferator-activated receptor γ expression in colorectal adenoma.
abstract: OBJECTIVE
  To investigate the expressions of leptin and peroxisome proliferator-activated receptor γ (PPARG) in relation to body mass index (BMI).
  
  
  METHODS
  We evaluated leptin and PPARG expression in 30 adenomas over 1 cm in size by immunohistochemical staining. In addition, clinicopathologic features including BMI were assessed.
  
  
  RESULTS
  PPARG and leptin expression showed a strong positive correlation (P = 0.035). The average BMI of the leptin-positive group was higher than that of the leptin-negative group (25.4 ± 3.4 kg/m(2)vs 22.6 ± 2.4 kg/m(2), P = 0.018), and leptin expression was significantly correlated with high BMI (P = 0.024). Leptin expression was more frequently observed in intermediate/high grade dysplasia than in low grade dysplasia (P = 0.030). However, PPARG expression was not correlated with BMI and grade of dysplasia.
  
  
  CONCLUSIONS
  BMI has influenced on the leptin expression of colorectal adenoma. The exact mechanism underlies the strong correlation between leptin and PPARG expression needs further study.
authors.affiliation: Department of Internal Medicine, Seoul Paik Hospital, Inje University College of Medicine, Seoul 100-032, South Korea.
authors.forename: Hyung Hun
authors.initials: HH
authors.lastname: Kim
authors.forename: You Sun
authors.initials: YS
authors.lastname: Kim
authors.forename: Yun Kyung
authors.initials: YK
authors.lastname: Kang
authors.forename: Jeong Seop
authors.initials: JS
authors.lastname: Moon
mesh_terms: D000236:Adenoma / Q000378:metabolism* / Q000473:pathology; D000328:Adult; D015992:Body Mass Index; D045744:Cell Line, Tumor; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D020738:Leptin / Q000378:metabolism*; D008297:Male; D046228:Microarray Analysis; D008875:Middle Aged; D009765:Obesity / Q000503:physiopathology; D047495:PPAR gamma / Q000378:metabolism*
chemical_list: D020738:Leptin; D047495:PPAR gamma