title: Evaluation of interleukin 28B single nucleotide polymorphisms in infants suffering from bronchiolitis.
abstract: The genetic diversity of the host is believed to be the key of the diversity in the clinical presentation of bronchiolitis. The aim of this study was to determine whether the known rs12979860 and rs8099917 single nucleotide polymorphisms (SNPs) in interleukin (IL)28B region, influence clinical features and natural history of bronchiolitis. Both SNPs showed no significant association with the risk of hospitalization for respiratory syncytial virus (RSV), viral load, disease severity, and other clinical features of patients. Interestingly infants carrying IL28B rs12979860 TT genotype had lower age at hospital admission than that of infants carrying CC/CT genotypes. Overall our results indicate that both IL28B SNPs had no impact on the clinical course of bronchiolitis with the only exception of the IL28B rs12979860 SNP which increased the risk of hospitalization for bronchiolitis at early age.
authors.affiliation: Department of Molecular Medicine, Laboratory of Virology, "Sapienza" University of Rome, Italy. carolina.scagnolari@uniroma1.it
authors.forename: Carolina
authors.initials: C
authors.lastname: Scagnolari
authors.forename: Fabio
authors.initials: F
authors.lastname: Midulla
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Riva
authors.forename: Katia
authors.initials: K
authors.lastname: Monteleone
authors.forename: Angelo
authors.initials: A
authors.lastname: Solimini
authors.forename: Enea
authors.initials: E
authors.lastname: Bonci
authors.forename: Giulia
authors.initials: G
authors.lastname: Cangiano
authors.forename: Paola
authors.initials: P
authors.lastname: Papoff
authors.forename: Corrado
authors.initials: C
authors.lastname: Moretti
authors.forename: Alessandra
authors.initials: A
authors.lastname: Pierangeli
authors.forename: Guido
authors.initials: G
authors.lastname: Antonelli
mesh_terms: D001988:Bronchiolitis / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D005260:Female; D005838:Genotype; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D007223:Infant; D007372:Interferons; D007378:Interleukins / Q000235:genetics* / Q000276:immunology; D008297:Male; D020641:Polymorphism, Single Nucleotide; D018357:Respiratory Syncytial Virus Infections / Q000235:genetics / Q000276:immunology / Q000473:pathology; D012136:Respiratory Syncytial Viruses / Q000302:isolation & purification; D012720:Severity of Illness Index; D019562:Viral Load; D000095022:Interferon Lambda
chemical_list: D007372:Interferons; D007378:Interleukins; C000624353:interferon-lambda, human; D000095022:Interferon Lambda