title: Small interfering RNA specific for N-methyl-D-aspartate receptor 2B offers neuroprotection to dopamine neurons through activation of MAP kinase.
abstract: In the present study, N-methyl-D-aspartate receptor 2B (NR2B)-specific siRNA was applied in parkinsonian models. Our previous results showed that reduction in expression of N-methyl-D-aspartate receptor 1 (NR1), the key subunit of N-methyl-D-aspartate receptors, by antisense oligos ameliorated the motor symptoms in the 6-hydroxydopamine (6-OHDA)-lesioned rat, an animal model of Parkinson's disease (PD).
authors.affiliation: Department of Biology, Hong Kong Baptist University, Kowloon Tong, Hong Kong, China.
authors.forename: Olivia T W
authors.initials: OT
authors.lastname: Ng
authors.forename: L W
authors.initials: LW
authors.lastname: Chen
authors.forename: Y S
authors.initials: YS
authors.lastname: Chan
authors.forename: Ken K L
authors.initials: KK
authors.lastname: Yung
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D059290:Dopaminergic Neurons / Q000378:metabolism* / Q000473:pathology; D004789:Enzyme Activation / Q000502:physiology; D020935:MAP Kinase Signaling System / Q000502:physiology*; D008297:Male; D018696:Neuroprotective Agents / Q000378:metabolism*; D020734:Parkinsonian Disorders / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control; D034741:RNA, Small Interfering / Q000096:biosynthesis* / Q000235:genetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000096:biosynthesis* / Q000235:genetics
chemical_list: C121001:NR2B NMDA receptor; D018696:Neuroprotective Agents; D034741:RNA, Small Interfering; D016194:Receptors, N-Methyl-D-Aspartate