title: Breast composition measurement with a cadmium-zinc-telluride based spectral computed tomography system.
abstract: OBJECTIVE
  To investigate the feasibility of breast tissue composition in terms of water, lipid, and protein with a cadmium-zinc-telluride (CZT) based computed tomography (CT) system to help better characterize suspicious lesions.
  
  
  METHODS
  Simulations and experimental studies were performed using a spectral CT system equipped with a CZT-based photon-counting detector with energy resolution. Simulations of the figure-of-merit (FOM), the signal-to-noise ratio (SNR) of the dual energy image with respect to the square root of mean glandular dose (MGD), were performed to find the optimal configuration of the experimental acquisition parameters. A calibration phantom 3.175 cm in diameter was constructed from polyoxymethylene plastic with cylindrical holes that were filled with water and oil. Similarly, sized samples of pure adipose and pure lean bovine tissues were used for the three-material decomposition. Tissue composition results computed from the images were compared to the chemical analysis data of the tissue samples.
  
  
  RESULTS
  The beam energy was selected to be 100 kVp with a splitting energy of 40 keV. The tissue samples were successfully decomposed into water, lipid, and protein contents. The RMS error of the volumetric percentage for the three-material decomposition, as compared to data from the chemical analysis, was estimated to be approximately 5.7%.
  
  
  CONCLUSIONS
  The results of this study suggest that the CZT-based photon-counting detector may be employed in the CT system to quantify the water, lipid, and protein mass densities in tissue with a relatively good agreement.
authors.affiliation: Department of Radiological Sciences, University of California, Irvine, CA 92697, USA.
authors.forename: Huanjun
authors.initials: H
authors.lastname: Ding
authors.forename: Justin L
authors.initials: JL
authors.lastname: Ducote
authors.forename: Sabee
authors.initials: S
authors.lastname: Molloi
mesh_terms: D000818:Animals; D001940:Breast / Q000737:chemistry* / Q000166:cytology; D019187:Cadmium Compounds / Q000737:chemistry*; D002138:Calibration; D002417:Cattle; D005260:Female; D007091:Image Processing, Computer-Assisted; D008327:Mammography / Q000379:methods* / Q000592:standards; D019047:Phantoms, Imaging; D017785:Photons; D012015:Reference Standards; D015203:Reproducibility of Results; D013691:Tellurium / Q000737:chemistry*; D014057:Tomography, X-Ray Computed / Q000379:methods* / Q000592:standards; D015032:Zinc / Q000737:chemistry*
chemical_list: D019187:Cadmium Compounds; D015032:Zinc; D013691:Tellurium; C028337:cadmium telluride