title: In vitro antioxidant activity study of novel chromone derivatives.
abstract: Forty-eight chromone derivatives were evaluated for their antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl free radical scavenging assay, ferrous ions (Fe(2+) ) chelating activity test, total antioxidant activity test (Ferric thiocyanate and Thiobarbituric acid methods), and total reductive capability (potassium ferricyanide reduction). 7,8-Dihydroxy-2-(3'-trifluoromethylphenyl)-3-(3″-trifluoromethylbenzoyl) chromone 32 showed stronger radical scavenging and metal chelating activities than butylated hydroxytoluene, vitamin E, and trolox. Chromone derivatives that exhibited good radical scavenging and metal chelating also displayed strong total antioxidant and reductive power activities. The results obtained from this study indicated that the synthesized chromone derivatives have remarkable antioxidant activity.
authors.affiliation: Faculty of Pharmacy, Siam University, 38 Petkasem Road, Bangkok 10160, Thailand.
authors.forename: Narumol
authors.initials: N
authors.lastname: Phosrithong
authors.forename: Weerasak
authors.initials: W
authors.lastname: Samee
authors.forename: Patcharawee
authors.initials: P
authors.lastname: Nunthanavanit
authors.forename: Jiraporn
authors.initials: J
authors.lastname: Ungwitayatorn
mesh_terms: D002614:Chelating Agents / Q000737:chemistry*; D002867:Chromones / Q000737:chemistry*; D005292:Ferricyanides / Q000737:chemistry; D016166:Free Radical Scavengers / Q000737:chemistry*; D008670:Metals / Q000737:chemistry; D010084:Oxidation-Reduction
chemical_list: D002614:Chelating Agents; D002867:Chromones; D005292:Ferricyanides; D016166:Free Radical Scavengers; D008670:Metals; C007931:hexacyanoferrate III