title: Prevalence of hepatitis C virus infection and human immunodeficiency virus in a cohort of Egyptian hemophiliac children.
abstract: OBJECTIVE
  The risk of blood-borne infections, especially hepatitis C virus (HCV) and human immunodeficiency virus (HIV) infection still remains in developing countries among children receiving blood products as hemophiliacs, but the risk is not known in Egypt. The objective of this study was to detect the prevalence of HCV and HIV infection among hemophiliac children to know the magnitude of the problem and determine potential risk factors.
  
  
  METHODS
  This was a cross-sectional study conducted on 100 hemophiliac children that assessed the liver clinically and by laboratory tests. All children were screened for HCV and HIV antibodies by enzyme-linked immunosorbent assay. Those with positive HCV antibody titre were tested by polymerase chain reaction (HCV-PCR).
  
  
  RESULTS
  Forty were positive for HCV antibodies with 19 children (47.5%) HCV-PCR positive as well. The mean age, average frequency of bleeds/year, dose of replacement therapy/year and alanine aminotransferase (ALT) levels were significantly high in HCV-antibody and PCR positive patients as compared to HCV antibody and PCR negative ones. None of our patients had clinical evidence of hepatic involvement or was co-infected with HIV.
  
  
  CONCLUSIONS
  HIV infection does not appear to be a current health problem in Egyptian hemophiliac children though the prevalence of HCV infection is still high.
authors.affiliation: Departments of Pediatrics, Cairo University, Egypt. magywahab@yahoo.com
authors.forename: Magy S
authors.initials: MS
authors.lastname: Abdelwahab
authors.forename: Mona S
authors.initials: MS
authors.lastname: El-Raziky
authors.forename: Normine A
authors.initials: NA
authors.lastname: Kaddah
authors.forename: Heba H
authors.initials: HH
authors.lastname: Abou-Elew
mesh_terms: D000293:Adolescent; D016913:Blood Component Transfusion / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D004534:Egypt / Q000453:epidemiology; D005260:Female; D015658:HIV Infections / Q000453:epidemiology* / Q000209:etiology; D006467:Hemophilia A; D002836:Hemophilia B; D006526:Hepatitis C / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D008297:Male; D015995:Prevalence; D012307:Risk Factors