title: Effects of a meal rich in 1,3-diacylglycerol on postprandial cardiovascular risk factors and the glucose-dependent insulinotropic polypeptide in subjects with high fasting triacylglycerol concentrations.
abstract: It was previously reported that compared to triacylglycerol (TAG) oil, diacylglycerol (DAG) oil improves postprandial lipid response. However, the effects of DAG oil on postprandial hyperglycemia and incretin response have not yet been determined. In this study, the effects of DAG oil on both postprandial hyperlipidemia and hyperglycemia and the response to the glucose-dependent insulinotropic polypeptide (GIP) were studied. This randomized, double-blind, crossover study analyzed data for 41 individuals with high fasting triacylglycerol concentrations. The subjects ingested test meals (30.3 g of protein, 18.6 g of fat, and 50.1 g of carbohydrate) containing 10 g of DAG oil (DAG meal) or TAG oil (TAG meal) after fasting for at least 12 h. Blood samples were collected prior to and 0.5, 2, 3, 4, and 6 h after ingestion of the test meal. Postprandial TAG concentrations were significantly lower after the DAG meal compared with the TAG meal. Postprandial TAG, insulin, and GIP concentrations were significantly lower after the DAG meal compared with the TAG meal in 26 subjects with fasting serum TAG levels between 1.36 and 2.83 mmol/L. DAG-oil-based meals, as a replacement for TAG oil, may provide cardiovascular benefits in high-risk individuals by limiting lipid and insulin excursions.
authors.affiliation: Health Care Food Research Laboratories, Kao Corporation, Tokyo, Japan. shoji.kentaro@kao.co.jp
authors.forename: Kentaro
authors.initials: K
authors.lastname: Shoji
authors.forename: Tomohito
authors.initials: T
authors.lastname: Mizuno
authors.forename: Daisuke
authors.initials: D
authors.lastname: Shiiba
authors.forename: Tadanobu
authors.initials: T
authors.lastname: Kawagoe
authors.forename: Yuuki
authors.initials: Y
authors.lastname: Mitsui
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis*; D002318:Cardiovascular Diseases / Q000097:blood / Q000178:diet therapy* / Q000453:epidemiology / Q000517:prevention & control; D004075:Diglycerides / Q000008:administration & dosage* / Q000097:blood; D005215:Fasting / Q000097:blood; D005260:Female; D005749:Gastric Inhibitory Polypeptide / Q000097:blood*; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000150:complications*; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood*
chemical_list: D001786:Blood Glucose; D004075:Diglycerides; D007328:Insulin; D014280:Triglycerides; D005749:Gastric Inhibitory Polypeptide