title: [Homer protein expression after focal brain contusion in rats].
abstract: OBJECTIVE
  To investigate Homer protein expression after focal brain contusion and explore the relationship between expression and injury time.
  
  
  METHODS
  Focal brain contusion in rats was established and Homer protein expression in brain at different injury intervals after contusion was detected by immunohistochemistry and Western blotting.
  
  
  RESULTS
  A small amount of Homer positive expression cells were detected in control group, sham operated group and experimental group (0.5 h after contusion). The amount of Homer positive expression cells increased after 3 h and reached peak 12 h after contusion. The amount of positive cells continued to decrease 1 d after contusion and to the base level 7 d after contusion. Homer protein expression based on immunohistochemistry and Western blotting had statistical difference among adjacent groups.
  
  
  CONCLUSIONS
  Expression of Homer protein near the focal contusion area shows time dependence after brain contusion in rats.
authors.affiliation: Department of Forensic Pathology, School of Forensic Medicine, China Medical University, Shenyang 110001, China. wfy021021@163.com
authors.forename: Fu-Yuan
authors.initials: FY
authors.lastname: Wang
authors.forename: Ru-Bo
authors.initials: RB
authors.lastname: Li
authors.forename: Hong-Xia
authors.initials: HX
authors.lastname: Liang
authors.forename: Yu
authors.initials: Y
authors.lastname: Shen
authors.forename: Xiao-Chong
authors.initials: XC
authors.lastname: Guo
authors.forename: Zheng-Yin
authors.initials: ZY
authors.lastname: Wang
mesh_terms: D000818:Animals; D015153:Blotting, Western; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D001930:Brain Injuries / Q000378:metabolism* / Q000473:pathology; D002352:Carrier Proteins / Q000378:metabolism*; D003288:Contusions / Q000378:metabolism* / Q000473:pathology; D004195:Disease Models, Animal; D049429:Forensic Pathology; D000072233:Homer Scaffolding Proteins; D007150:Immunohistochemistry; D008297:Male; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013194:Staining and Labeling; D013997:Time Factors
chemical_list: D002352:Carrier Proteins; D000072233:Homer Scaffolding Proteins