title: How actin gets the PIP.
abstract: Actin polymerization is fundamental to many cellular activities, including motility, cytokinesis, and vesicle traffic. Actin dynamics must be tightly regulated so that cells execute a response appropriate to need, which is achieved through coordination of the functions of a molecular toolkit of proteins and phospholipids. Among the latter, phosphoinositides have a particularly important role, and PI(4,5)P₂ (phosphatidylinositol 4,5-bisphosphate) generates distinct phenotypic outcomes such as actin comet formation and membrane ruffling. New evidence reveals that it is not just the production of PI(4,5)P₂ that is important in determining outcome, but that changes in the abundance of other phosphoinositides also play a role.
authors.affiliation: Department of Cell Biology, University College London Institute of Ophthalmology, 11-43 Bath Street, London EC1V 9EL, UK. s.moss@ucl.ac.uk
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Moss
mesh_terms: D000199:Actins / Q000378:metabolism*; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D002465:Cell Movement / Q000502:physiology*; D006801:Humans; D019269:Phosphatidylinositol 4,5-Diphosphate / Q000378:metabolism*
chemical_list: D000199:Actins; D019269:Phosphatidylinositol 4,5-Diphosphate