title: Antidiarrhetic loperamide hydrochloride.
abstract: Single crystals of the anhydrous form of the title compound {systematic name: 1-[3-(dimethylcarbamoyl)-3,3-diphenylpropyl]-4-hydroxy-4-(4-chlorophenyl)piperidin-1-ium chloride}, C(29)H(34)ClN(2)O(2)(+)·Cl(-), were obtained by diffusion of acetone into a solution in 2-propanol. In the structure, N-H...Cl(-) and O-H...Cl(-) hydrogen bonds connect neighbouring molecules and chloride anions to form chains along the c-axis direction. Neighbouring chains along the b-axis direction are connected by intermolecular C-H...Cl(-) contacts, defining layers parallel to the (100) planes. The layers are connected by weak intermolecular C-H...Cl interactions only, which may account for the plate-like shape of the crystals.
authors.affiliation: University of Frankfurt, Institute of Inorganic and Analytical Chemistry, Frankfurt am Main, Germany.
authors.forename: Jürgen
authors.initials: J
authors.lastname: Brüning
authors.forename: Dragica
authors.initials: D
authors.lastname: Podgorski
authors.forename: Edith
authors.initials: E
authors.lastname: Alig
authors.forename: Jan W
authors.initials: JW
authors.lastname: Bats
authors.forename: Martin U
authors.initials: MU
authors.lastname: Schmidt
mesh_terms: D000930:Antidiarrheals / Q000737:chemistry*; D018360:Crystallography, X-Ray; D006860:Hydrogen Bonding; D008139:Loperamide / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D000930:Antidiarrheals; D008139:Loperamide