title: An 18-year-old woman with Kabuki syndrome, immunoglobulin deficiency and granulomatous lymphocytic interstitial lung disease.
abstract: Granulomatous lymphocytic interstitial lung disease, or GLILD, is an uncommon condition associated with common variable immunodeficiency (CVID). We present an interesting case of an 18-year-old woman with Kabuki syndrome and CVID who was seen in our clinic for an abnormal chest CT scan. She was subsequently diagnosed with GLILD. There are no established guidelines for the treatment of GLILD in CVID. Immune globulin replacement therapy is the main treatment for CVID and higher doses of intravenous immunoglobulin (IVIG) may prevent the progression of chronic lung disease. Patients with CVID and GLILD are at increased risk for malignancy and their prognosis is worse compared to patients with CVID without GLILD.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, University of Connecticut Health Center, Farmington, USA.
authors.forename: Jose Angelo A
authors.initials: JA
authors.lastname: De Dios
authors.forename: Adnan A
authors.initials: AA
authors.lastname: Javaid
authors.forename: Enrique
authors.initials: E
authors.lastname: Ballesteros
authors.forename: Mark L
authors.initials: ML
authors.lastname: Metersky
mesh_terms: D000015:Abnormalities, Multiple / Q000175:diagnosis*; D000293:Adolescent; D017074:Common Variable Immunodeficiency / Q000150:complications / Q000175:diagnosis*; D005145:Face / Q000002:abnormalities; D005260:Female; D006099:Granuloma / Q000150:complications / Q000175:diagnosis*; D006402:Hematologic Diseases / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000150:complications / Q000175:diagnosis*; D015837:Vestibular Diseases / Q000150:complications / Q000175:diagnosis*