title: Governance of clinical research.
abstract: We review the principal methods and issues in the governance of clinical research: oversight of human research by federal offices, certification of clinical trial centers, management of conflict of interest in clinical research, and trial registration and reporting.
authors.affiliation: Division of Gastroenterology and Hepatology and Office of Human Research Protection, College of Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA. camilleri.michael@mayo.edu
authors.forename: Michael
authors.initials: M
authors.lastname: Camilleri
authors.forename: William J
authors.initials: WJ
authors.lastname: Tremaine
mesh_terms: D035843:Biomedical Research / Q000941:ethics / Q000331:legislation & jurisprudence / Q000592:standards; D002568:Certification; D002986:Clinical Trials as Topic / Q000941:ethics / Q000331:legislation & jurisprudence / Q000592:standards; D016265:Conflict of Interest; D028744:Ethics Committees, Research; D006077:Government Agencies; D033161:Government Regulation; D006801:Humans; D011643:Publishing / Q000941:ethics / Q000331:legislation & jurisprudence / Q000592:standards; D014481:United States