title: Pathogenesis of lupus-like nephritis through autoimmune antibody produced by CD180-negative B lymphocytes in NZBWF1 mouse.
abstract: Toll-like receptors appear to play an important role in the pathogenesis of lupus-like nephritis in mice. In human and mouse, CD180 is a homologue of TLR4. In SLE patients, the number of CD180-negative B cells in peripheral blood changes in parallel with disease activity. In the present study using NZBWF1 mice, the population of splenic CD180-negative B cells increased with progression of renal lesions and aging. These cells produced both anti-dsDNA and histone antibodies; the peripheral blood levels of anti-dsDNA antibody increased markedly with aging. B cells infiltrating into renal lesions were CD180-negative and produced anti-dsDNA antibody. Considered together, these findings indicate that CD180-negative B cells contribute significantly to development of SLE-like morbidity in NZBWF1 mice by autoantibody production.
authors.affiliation: Department of Pathology, School of Medicine, Toho University, Omori-Nishi, Ota-Ku, Tokyo, Japan. kazuko41@med.toho-u.ac.jp
authors.forename: Kazuko
authors.initials: K
authors.lastname: Fujita
authors.forename: Yoshikiyo
authors.initials: Y
authors.lastname: Akasaka
authors.forename: Taku
authors.initials: T
authors.lastname: Kuwabara
authors.forename: Bing
authors.initials: B
authors.lastname: Wang
authors.forename: Kaoru
authors.initials: K
authors.lastname: Tanaka
authors.forename: Itaru
authors.initials: I
authors.lastname: Kamata
authors.forename: Tomoko
authors.initials: T
authors.lastname: Yokoo
authors.forename: Toshio
authors.initials: T
authors.lastname: Kinoshita
authors.forename: Ami
authors.initials: A
authors.lastname: Iuchi
authors.forename: Yuri
authors.initials: Y
authors.lastname: Akishima-Fukasawa
authors.forename: Yukio
authors.initials: Y
authors.lastname: Ishikawa
authors.forename: Motonari
authors.initials: M
authors.lastname: Kondo
authors.forename: Toshiharu
authors.initials: T
authors.lastname: Ishii
mesh_terms: D000375:Aging / Q000276:immunology; D000818:Animals; D015703:Antigens, CD / Q000378:metabolism*; D001323:Autoantibodies / Q000096:biosynthesis*; D001327:Autoimmune Diseases / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*; D015551:Autoimmunity; D001402:B-Lymphocytes / Q000276:immunology*; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D007668:Kidney / Q000276:immunology / Q000473:pathology; D008181:Lupus Nephritis / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008814:Mice, Inbred NZB; D013154:Spleen / Q000276:immunology
chemical_list: D015703:Antigens, CD; D001323:Autoantibodies; C490500:Ly78 protein, mouse