title: Continuous computation in engineered gene circuits.
abstract: In this paper we consider the problem of representation and measurement in genetic circuits, and investigate how they can affect the reliability of engineered systems. We propose a design scheme, based on the notion of continuous computation, which addresses these issues. We illustrate the methodology by showing how a concept from computer architecture (namely, branch prediction) may be implemented in vivo, using a distributed approach. Simulation results confirm the in-principle feasibility of our method, and offer valuable insights into its future laboratory validation.
authors.affiliation: School of Computing, Mathematics and Digital Technology, Manchester Metropolitan University, United Kingdom. a.moreno@mmu.ac.uk
authors.forename: Angel
authors.initials: A
authors.lastname: Goñi-Moreno
authors.forename: Martyn
authors.initials: M
authors.lastname: Amos
mesh_terms: D003198:Computer Simulation; D003199:Computer Systems; D039301:Computers, Molecular / Q000639:trends*; D053263:Gene Regulatory Networks / Q000235:genetics*; D008962:Models, Theoretical; D009355:Neomycin; D058615:Synthetic Biology / Q000295:instrumentation / Q000379:methods*
chemical_list: D009355:Neomycin