title: Preemptive carprofen for peri-operative analgesia in dogs undergoing Tibial Plateau Leveling Osteotomy (TPLO): a prospective, randomized, blinded, placebo controlled clinical trial.
abstract: Eighteen client-owned dogs undergoing Tibial Plateau Leveling Osteotomy (TPLO) were included in this blinded clinical study and randomly assigned to one of two treatment groups. Group C (carprofen) received intravenous (IV) carprofen, 4 mg/kg, prior to anesthesia, whereas group P (placebo) received IV saline. General anesthesia was maintained with isoflurane in oxygen and a constant rate infusion (CRI) of sufentanyl IV. Intra-operatively, assessment of nociception was based on changes in physiological parameters and on the analgesics requirement, whereas in the post-operative period evaluation of pain was performed by using a Hellyer and Gaynor pain score and by comparing the doses of rescue buprenorphine required by the two treatment groups. Although no statistically significant differences in intra-operative sufentanyl doses were found between treatment groups, group C had superior cardiovascular stability, and lower post-operative pain scores and rescue buprenorphine doses than group P. Our results indicate that administration of carprofen prior to surgery was effective in improving peri-operative analgesia in dogs undergoing TPLO.
authors.affiliation: Surgery and Radiodiagnostics Division, Department of Veterinary Clinical Science, University of Perugia, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Bufalari
authors.forename: C
authors.initials: C
authors.lastname: Maggio
authors.forename: I
authors.initials: I
authors.lastname: Cerasoli
authors.forename: U
authors.initials: U
authors.lastname: Morath
authors.forename: C
authors.initials: C
authors.lastname: Adami
mesh_terms: D000698:Analgesia / Q000379:methods / Q000662:veterinary*; D000818:Animals; D016118:Anterior Cruciate Ligament / Q000601:surgery; D000070598:Anterior Cruciate Ligament Injuries; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects; D002227:Carbazoles / Q000008:administration & dosage*; D004285:Dogs / Q000502:physiology* / Q000601:surgery*; D006339:Heart Rate / Q000187:drug effects; D010027:Osteotomy / Q000379:methods / Q000662:veterinary*; D010149:Postoperative Pain / Q000517:prevention & control / Q000662:veterinary; D019990:Perioperative Care / Q000662:veterinary; D012421:Rupture / Q000601:surgery / Q000662:veterinary; D013977:Tibia / Q000601:surgery
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002227:Carbazoles; C007005:carprofen