title: Glucocorticoid and calcitonin receptor expression in central giant cell lesions: implications for therapy.
abstract: Central giant cell lesion is an uncommon benign jaw lesion, with uncertain aetiology, and variable clinical behaviour. Studies of molecular markers may help to understand the nature and behaviour of this lesion, and eventually may represent a target for pharmacological approaches to treatment. The aim of this study was to analyse the expression of glucocorticoid and calcitonin receptors in central giant cell lesions before and after treatment with intralesional steroid. Paraffin-embedded blocks from patients who underwent treatment with intralesional triamcinolone hexacetonide injections were stained immunohistochemically. Biological material from patients who underwent a surgical procedure after treatment were tested immunohistochemically. 18 cases (9 aggressive and 9 non-aggressive) were included. The difference in calcitonin receptor expression was not statistically significant between the aggressive and non-aggressive lesions and between the patients with a good response and those with a moderate/negative response to treatment. Glucocorticoid receptor expression in the multinucleated giant cells was higher in patients with a good response. It can be postulated that immunohistochemical staining for glucocorticoid receptors may provide a tool for selecting the therapeutic strategy. An H-score greater than 48 for glucocorticoid receptors in multinucleated giant cells predicted a good response in this study.
authors.affiliation: Department of Dental Clinic, Discipline of Oral and Maxillofacial Surgery and Stomatology, Federal University of Ceara School of Dentistry, Fortaleza, Brazil.
authors.forename: R L M
authors.initials: RL
authors.lastname: Nogueira
authors.forename: M H G
authors.initials: MH
authors.lastname: Faria
authors.forename: R L V
authors.initials: RL
authors.lastname: Osterne
authors.forename: R B
authors.initials: RB
authors.lastname: Cavalcante
authors.forename: R A
authors.initials: RA
authors.lastname: Ribeiro
authors.forename: S H B
authors.initials: SH
authors.lastname: Rabenhorst
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D015726:Giant Cells / Q000473:pathology; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use; D006101:Granuloma, Giant Cell / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D006801:Humans; D015552:Injections, Intralesional; D007571:Jaw Diseases / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D008297:Male; D008336:Mandibular Diseases / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D008439:Maxillary Diseases / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D018003:Receptors, Calcitonin / Q000032:analysis*; D011965:Receptors, Glucocorticoid / Q000032:analysis*; D017154:Stromal Cells / Q000473:pathology; D016896:Treatment Outcome; D014222:Triamcinolone Acetonide / Q000008:administration & dosage / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D005938:Glucocorticoids; D018003:Receptors, Calcitonin; D011965:Receptors, Glucocorticoid; D014222:Triamcinolone Acetonide