title: Cardio-renal syndrome: new perspective in diagnostics.
abstract: Chronic heart failure and chronic renal failure are at epidemic proportions. These patients have significantly altered cardiac, renal, and all-cause outcomes. Much of the current research has focused on treating these individual organs in isolation. Although there are positive data on outcomes with neurohormonal modulation, they, however, remain underused. At present, data lacks for novel treatment options, while evidence continues to point at significantly worsened prognosis. Current diagnostic tools that detect acute changes in renal function or renal injury appear retrospective, which often hinder meaningful diagnostic and therapeutic decisions. This review is aimed at exploring the importance of accurate assessment of renal function for the heart failure patient by providing a synopsis on cardio-renal physiology and establishing the possibility of novel approaches in bridging the divide.
authors.affiliation: Centre of Cardiovascular Research and Education in Therapeutics, Department of Epidemiology and Preventive Medicine, Monash University and Alfred Hospital, Melbourne Victoria, Australia. balaniyngkaran@hotmail.com
authors.forename: P
authors.initials: P
authors.lastname: Iyngkaran
authors.forename: H
authors.initials: H
authors.lastname: Schneider
authors.forename: P
authors.initials: P
authors.lastname: Devarajan
authors.forename: N
authors.initials: N
authors.lastname: Anavekar
authors.forename: H
authors.initials: H
authors.lastname: Krum
authors.forename: C
authors.initials: C
authors.lastname: Ronco
mesh_terms: D015415:Biomarkers / Q000032:analysis / Q000097:blood*; D059347:Cardio-Renal Syndrome / Q000175:diagnosis* / Q000503:physiopathology*; D006801:Humans; D012079:Renal Circulation / Q000502:physiology
chemical_list: D015415:Biomarkers