title: Particulate matter (PM10) exposure induces endothelial dysfunction and inflammation in rat brain.
abstract: Epidemiological studies suggest that particulate matter (PM(10)) inhalation was associated with adverse effects on brain-related health, however, existing experimental data lacked relevant evidences. In this study, we treated Wistar rats with PM(10) at different concentrations (0.3, 1, 3 and 10 mg/kg body weight (bw)), and investigated endothelial dysfunction and inflammatory responses in the brain. The results indicate that mild pathological abnormal occurred after 15-day exposure (five times with 3 days each), followed by the changes of endothelial mediators (ET-1 and eNOS) and inflammatory markers (IL-1β, TNF-α, COX-2, iNOS and ICAM-1). Also, the sample up-regulated bax/bcl-2 ratio and p53 expression, and induced neuronal apoptosis. It implicates that PM(10) exerted injuries to mammals' brain, and the mechanisms might be involved in endothelial dysfunction and inflammatory responses.
authors.affiliation: College of Environment and Resource, Shanxi University, Taiyuan, Shanxi 030006, PR China.
authors.forename: Lin
authors.initials: L
authors.lastname: Guo
authors.forename: Na
authors.initials: N
authors.lastname: Zhu
authors.forename: Zhen
authors.initials: Z
authors.lastname: Guo
authors.forename: Guang-ke
authors.initials: GK
authors.lastname: Li
authors.forename: Chu
authors.initials: C
authors.lastname: Chen
authors.forename: Nan
authors.initials: N
authors.lastname: Sang
authors.forename: Qing-chen
authors.initials: QC
authors.lastname: Yao
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D051017:Apoptosis Regulatory Proteins / Q000378:metabolism; D001921:Brain / Q000473:pathology*; D004396:Coloring Agents; D016207:Cytokines / Q000378:metabolism; D019332:Endothelin-1 / Q000378:metabolism; D004730:Endothelium, Vascular / Q000187:drug effects*; D020287:In Situ Nick-End Labeling; D007249:Inflammation / Q000139:chemically induced*; D008297:Male; D052250:Nitric Oxide Synthase Type III / Q000378:metabolism; D010316:Particle Size; D052638:Particulate Matter / Q000009:adverse effects*; D012313:RNA / Q000096:biosynthesis / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar; D060888:Real-Time Polymerase Chain Reaction
chemical_list: D051017:Apoptosis Regulatory Proteins; D004396:Coloring Agents; D016207:Cytokines; D019332:Endothelin-1; D052638:Particulate Matter; D012313:RNA; D052250:Nitric Oxide Synthase Type III