title: Adjuvant therapy in stage I carcinoma of the breast: the influence of multigene analyses and molecular phenotyping.
abstract: BACKGROUND
  Breast Health International and the Kimmel Cancer Center of Thomas Jefferson University cosponsored a consensus conference that included an international group of experts.
  
  
  METHODS
  Since the adoption of adjuvant chemotherapy for stage I, lymph node-negative breast cancers in 1988, investigators have tried to "fine-tune" the treatment criteria. At this consensus conference, the group debated recommendations for adjuvant hormone and cytotoxic chemotherapy in stage I breast cancers.
  
  
  RESULTS
  Discussions during the conference addressed issues of adjuvant therapy for stage I breast cancer and the influence of multigene analyses and molecular phenotyping. The panelists discussed various demographic, morphologic, biologic, and genetic factors expressed by individual tumors and their influence on treatment decisions.
  
  
  CONCLUSIONS
  The panel tried to create guidelines for the consideration of adjuvant treatment of these patients, including both hormone and cytotoxic regimens. They also encouraged further research into the molecular analysis of breast cancers and the introduction of clinical trials based on current data, although they concluded that it is too early to add any of those analyses into the decision-making algorithms of recommendations for the treatment of stage I breast cancer.
authors.affiliation: Breast Care Center, Department of Surgery and Medical Oncology, Jefferson Medical College, Philadelphia, Pennsylvania, USA. gordon.schwartz@jefferson.edu
authors.forename: Gordon F
authors.initials: GF
authors.lastname: Schwartz
authors.forename: Jorge
authors.initials: J
authors.lastname: Reis-Fihlo
authors.forename: Lajos
authors.initials: L
authors.lastname: Pusztai
authors.forename: Ian S
authors.initials: IS
authors.lastname: Fentiman
authors.forename: Roland
authors.initials: R
authors.lastname: Holland
authors.forename: Harry
authors.initials: H
authors.lastname: Bartelink
authors.forename: Emiel J T
authors.initials: EJ
authors.lastname: Rutgers
authors.forename: Lawrence J
authors.initials: LJ
authors.lastname: Solin
authors.forename: Juan
authors.initials: J
authors.lastname: Palazzo
mesh_terms: D001943:Breast Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D009376:Neoplasms, Hormone-Dependent / Q000188:drug therapy / Q000378:metabolism; D017410:Practice Guidelines as Topic