title: AcrySof cachet phakic intraocular lens in myopic patients: visual performance, wavefront error, and lens position.
abstract: OBJECTIVE
  To evaluate visual and aberrometric outcomes and position of the AcrySof Cachet (Alcon Laboratories Inc) angle-supported phakic intraocular lens (PIOL) for correction of myopia in adults.
  
  
  METHODS
  This prospective study included 36 consecutive eyes with moderate to high myopia in which an AcrySof Cachet PIOL was implanted to minimize refractive error. Follow-up was up to 1 year.
  
  
  RESULTS
  Mean manifest spherical equivalent refraction reduced significantly from -14.90 ± 0.90 diopters (D) to -0.29 ± 0.30 D at 1 month and remained stable at 1 year (P<.001). Mean uncorrected distance visual acuity was >0.1 logMAR (20/20 Snellen) in 56% of patients and >0.3 logMAR (20/25 Snellen) in 100% of patients. Corrected distance visual acuity was >0.1 logMAR (20/20 Snellen) in 78% of patients and >0.3 logMAR (20/25 Snellen) in 100% of patients. Mean endothelium-PIOL distance and mean PIOL-crystalline distance were within recommended values at all postoperative evaluations. Statistically significant variations for these variables were not observed. Anterior chamber depth, safety center distance, and vault center distance showed significant reduction after accommodation (P<.01). Anterior chamber depth and safety center distance significantly increased after pupil dilation (P<.01). Mean percentage of endothelial cell loss was 4.04% at 1 year. The root-mean-square of total higher order aberrations and spherical, coma, and trefoil aberrations did not change significantly from pre- to postoperatively.
  
  
  CONCLUSIONS
  The AcrySof Cachet PIOL was effective in the correction of moderate to high myopia and provided excellent visual performance with no modification of physiologic ocular wavefront error. Adequate distance from the cornea and crystalline lens was maintained with no significant change during follow-up and under different environmental conditions.
authors.affiliation: Department of Medicine and Science of Aging, Eye Clinic, University "G. d'Annunzio" Chieti-Pascara, Chieti, Italy.
authors.forename: Leonardo
authors.initials: L
authors.lastname: Mastropasqua
authors.forename: Lisa
authors.initials: L
authors.lastname: Toto
authors.forename: Luca
authors.initials: L
authors.lastname: Vecchiarino
authors.forename: Emanuele
authors.initials: E
authors.lastname: Doronzo
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Mastropasqua
authors.forename: Marta
authors.initials: M
authors.lastname: Di Nicola
mesh_terms: D000180:Acrylic Resins; D000328:Adult; D000869:Anterior Eye Segment / Q000473:pathology; D055954:Corneal Endothelial Cell Loss / Q000175:diagnosis; D057108:Corneal Wavefront Aberration / Q000503:physiopathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D019654:Lens Implantation, Intraocular; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000503:physiopathology / Q000601:surgery*; D054120:Phakic Intraocular Lenses; D011446:Prospective Studies; D012029:Refraction, Ocular / Q000502:physiology; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology*
chemical_list: D000180:Acrylic Resins