title: Novel molecular combination deriving from natural aminoacids and polyphenols: Design, synthesis and free-radical scavenging activities.
abstract: Following the recent output of scientific publications in the matter of synergic activity between different antioxidants, we have undertaken the present study with the aim to synthesize new molecules with radical-scavengers activity based on the conjugation of bioactive portions (i.e. phenols, cysteine, methionine or tyrosine), characterized by different structures and mechanisms of action, to promote the simultaneous quenching of different radical species in the site of the oxidative damage. In this context, derivatives of phenolic acid, aminoacids and dopamine have been also prepared. The newly synthesized compounds were evaluated in vitro applying specific and complementary antioxidant test such as DPPH assay and ORAC test. As emerged from the evaluation, prerequisites for the activity of the synthesized molecules were: i) the maintenance of at least two hydroxylic groups on the aromatic moiety of phenolic portion, ii) the presence of a spacer between the aromatic moiety and the carbonilic group.
authors.affiliation: Department of Pharmaceutical Sciences, University of Ferrara, via Fossato di Mortara 17-19, 44121 Ferrara, Italy. vrs@unife.it
authors.forename: Vertuani
authors.initials: V
authors.lastname: Silvia
authors.forename: Anna
authors.initials: A
authors.lastname: Baldisserotto
authors.forename: Emanuela
authors.initials: E
authors.lastname: Scalambra
authors.forename: Gemma
authors.initials: G
authors.lastname: Malisardi
authors.forename: Elisa
authors.initials: E
authors.lastname: Durini
authors.forename: Stefano
authors.initials: S
authors.lastname: Manfredini
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000494:pharmacology; D004298:Dopamine / Q000737:chemistry; D015195:Drug Design; D016166:Free Radical Scavengers / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D007202:Indicators and Reagents / Q000494:pharmacology; D015394:Molecular Structure; D010851:Picrates / Q000494:pharmacology; D059808:Polyphenols / Q000737:chemistry*; D017382:Reactive Oxygen Species / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D000596:Amino Acids; D000975:Antioxidants; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D007202:Indicators and Reagents; D010851:Picrates; D059808:Polyphenols; D017382:Reactive Oxygen Species; C004931:1,1-diphenyl-2-picrylhydrazyl; D004298:Dopamine