title: Abnormal spontaneous interleukin 8 receptor expression: a brief report of two cases.
abstract: Interleukin 8 (CXCL8) is an autocrine chemokine specific for the chemoattraction and activation of granulocytes, NKT cells and T lymphocytes. Patients with tuberculosis and latent Mycobacterium tuberculosis infection were assessed for the spontaneous expression of CXCR1 (CD128) and CXCR2 on lymphocytes and monocytes. Compared with ex vivo profiles, increased spontaneous CXCR2 expression and normal CXCR1 expression were found on lymphocytes in two out of 59 individuals. Monocytes showed normal ex vivo profiles for both receptors. After stimulation with purified protein derivative, the in vitro levels of CXCL8 were below the median levels of all patients with prior tuberculosis. Spontaneous CXCR2 modulation did not cause notable variation in the in vitro levels of CXCL8.
authors.affiliation: Laboratório de Imunologia Clínica, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, RJ. pzuquim@ioc.fiocruz.br
authors.forename: Paulo
authors.initials: P
authors.lastname: Antas
authors.forename: Steven
authors.initials: S
authors.lastname: Holland
authors.forename: Timothy
authors.initials: T
authors.lastname: Sterling
mesh_terms: D016022:Case-Control Studies; D015331:Cohort Studies; D005434:Flow Cytometry; D006801:Humans; D055985:Latent Tuberculosis / Q000276:immunology; D008297:Male; D008875:Middle Aged; D023062:Receptors, Interleukin-8A / Q000096:biosynthesis*; D023063:Receptors, Interleukin-8B / Q000096:biosynthesis*; D014376:Tuberculosis / Q000276:immunology*
chemical_list: D023062:Receptors, Interleukin-8A; D023063:Receptors, Interleukin-8B