title: [Oxazole derivatives as compounds modifying radiation effects in the body of mice].
abstract: A new class of substances exhibiting radioprotective and radiosensitizing effects depending on the concentration of the substance has been found. The radioprotective effect is probably due to the resonant absorption of radiation energy and its transformation into low-energy forms, as well as reactions with water radiolysis products. We studied the effects of 2,5-difeniloxazole and di[2-(5-feniloxazolil)]benzene in various concentrations in conjunction with irradiation on the growth of melanoma B-16 in mice and the average time of their lives. When using individual doses of irradiation and doses of preparations, we observed an increase in the average lifetime of mice and a reduced tumor size. These data allow us to conclude about the possibility of using these substances in the radiotherapy of tumors.
authors.forename: E V
authors.initials: EV
authors.lastname: Burlakova
authors.forename: F S
authors.initials: FS
authors.lastname: Dukhovich
authors.forename: E N
authors.initials: EN
authors.lastname: Gorbatova
authors.forename: V D
authors.initials: VD
authors.lastname: Gaintseva
authors.forename: G P
authors.initials: GP
authors.lastname: Zhizhina
authors.forename: T M
authors.initials: TM
authors.lastname: Zavarykina
authors.forename: E M
authors.initials: EM
authors.lastname: Molochkina
authors.forename: N P
authors.initials: NP
authors.lastname: Pal'mina
authors.forename: M A
authors.initials: MA
authors.lastname: Smotriaeva
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Treshchenkova
authors.forename: L D
authors.initials: LD
authors.lastname: Fatkullina
authors.forename: L N
authors.initials: LN
authors.lastname: Shishkina
authors.forename: E L
authors.initials: EL
authors.lastname: Mal'tseva
mesh_terms: D000818:Animals; D001555:Benzene Derivatives / Q000737:chemistry / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects / Q000528:radiation effects; D004247:DNA / Q000187:drug effects* / Q000528:radiation effects; D053903:DNA Breaks, Double-Stranded / Q000187:drug effects; D004307:Dose-Response Relationship, Radiation; D008546:Melanoma, Experimental; D051379:Mice; D008807:Mice, Inbred BALB C; D010080:Oxazoles / Q000737:chemistry / Q000494:pharmacology*; D011837:Radiation-Protective Agents / Q000737:chemistry / Q000494:pharmacology*; D011838:Radiation-Sensitizing Agents / Q000737:chemistry / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects; D014867:Water / Q000737:chemistry; D014916:Whole-Body Irradiation
chemical_list: D001555:Benzene Derivatives; D010080:Oxazoles; D011837:Radiation-Protective Agents; D011838:Radiation-Sensitizing Agents; C571162:di(2-(5-phenyloxazolyl))benzene; D014867:Water; D004247:DNA; C009012:2,5-diphenyloxazole