title: Follow-up of natural products isolation.
abstract: Follow-up of natural products isolation refers to re-isolation of compound(s) of interest in larger amounts for further pharmacological testing, conclusive structure elucidation, structure modifications to synthesize analogs for structure-activity relationships (SAR) studies, preformulation and formulation studies or clinical trials. In addition to conventional synthetic chemistry approaches, several other methodologies can be applied for following-up natural products isolation. This chapter outlines, with specific examples, various strategies and methods involved in follow-up of natural products isolation.
authors.affiliation: Department of Pharmacy, School of Applied Sciences, University of Wolverhampton, Wolverhampton, WV11LY, UK.
authors.forename: Richard J P
authors.initials: RJ
authors.lastname: Cannell
authors.forename: Satyajit D
authors.initials: SD
authors.lastname: Sarker
authors.forename: Lutfun
authors.initials: L
authors.lastname: Nahar
mesh_terms: D000470:Alkaloids / Q000096:biosynthesis; D018943:Anthracyclines / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000378:metabolism; D001419:Bacteria / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D055162:Biocatalysis; D001688:Biological Products / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism; D053898:Biosynthetic Pathways / Q000235:genetics; D001711:Biotransformation; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000378:metabolism; D005591:Chemical Fractionation / Q000379:methods; D020650:Combinatorial Chemistry Techniques; D005658:Fungi / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D015870:Gene Expression; D006219:Halogens / Q000737:chemistry; D018942:Macrolides / Q000378:metabolism; D013256:Steroids / Q000378:metabolism; D013729:Terpenes / Q000378:metabolism; D014233:Tricarboxylic Acids / Q000378:metabolism
chemical_list: D000470:Alkaloids; D018943:Anthracyclines; D000900:Anti-Bacterial Agents; D001688:Biological Products; D019086:Bridged Bicyclo Compounds, Heterocyclic; D006219:Halogens; D018942:Macrolides; D013256:Steroids; D013729:Terpenes; D014233:Tricarboxylic Acids; C075117:squalestatin 1; C027837:moxidectin; C050476:nonactin