title: Continuous renal replacement therapy in children.
abstract: Over the past several decades, the epidemiology of acute kidney injury (AKI) in children has changed significantly. Pediatric patients with AKI frequently have co-morbid conditions, substantial fluid overload, and marked disease severity. At the same time, continuous renal replacement therapy (CRRT) has become the preferred modality for the management of these patients. This manuscript provides a state-of-the-art review of the technical aspects of pediatric CRRT and examines the most recent data regarding CRRT indications, timing of initiation, dosing, and outcomes in critically ill children.
authors.affiliation: Department of Pediatrics, Division of Nephrology, Stanford University Medical Center, 300 Pasteur Drive, Room G-306, Stanford, CA, 94035, USA. suthersm@stanford.edu.
authors.forename: Scott M
authors.initials: SM
authors.lastname: Sutherland
authors.affiliation: Department of Pediatrics, Division of Nephrology, Stanford University Medical Center, 300 Pasteur Drive, Room G-306, Stanford, CA, 94035, USA.
authors.forename: Steven R
authors.initials: SR
authors.lastname: Alexander
mesh_terms: D058186:Acute Kidney Injury / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D000367:Age Factors; D000925:Anticoagulants / Q000627:therapeutic use; D001783:Blood Flow Velocity; D002648:Child; D002675:Child, Preschool; D015897:Comorbidity; D016638:Critical Illness; D015199:Extracorporeal Membrane Oxygenation; D006440:Hemofiltration / Q000009:adverse effects / Q000401:mortality; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D010530:Peritoneal Dialysis; D012039:Regional Blood Flow; D006435:Renal Dialysis; D012307:Risk Factors; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants