title: Potential renoprotective effects of silymarin against nephrotoxic drugs: a review of literature.
abstract: Drug-induced nephrotoxicity (DIN) accounts for up to sixty percent of hospital acquired acute kidney injury. Several efforts have been made to reduce drug-induced renal damage; however, DIN remains a matter of concern, with substantial impact on patients and the health system. Silymarin is a drug that has been used for many years in alternate and modern medicine for treating hepatic diseases. Its antioxidant, anti-inflammatory and anti-apoptotic effects make it an interesting herbal medicine, and these properties have implicated this compound as a potential renoprotective agent. Based on the findings from animal studies, this review concluded that silymarin might exert significant protective or ameliorative effects against drug-induced kidney disease, especially against cisplatin-induced renal damage. Whether the protective administration of silymarin could be an effective clinical pharmacological strategy to prevent DIN is a question that remains to be answered in clinical trials.
authors.affiliation: Resident of Clinical Pharmacy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. dashtis@sina.tums.ac.ir
authors.forename: Simin
authors.initials: S
authors.lastname: Dashti-Khavidaki
authors.forename: Foroud
authors.initials: F
authors.lastname: Shahbazi
authors.forename: Hossein
authors.initials: H
authors.lastname: Khalili
authors.forename: Mahboob
authors.initials: M
authors.lastname: Lessan-Pezeshki
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced / Q000517:prevention & control; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced / Q000517:prevention & control*; D020011:Protective Agents / Q000494:pharmacology*; D012838:Silymarin / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D020011:Protective Agents; D012838:Silymarin