title: Influence of sealant fibrin on the wound healing of the pigs vocal folds.
abstract: Fibrin sealants or fibrin glue are products made from human plasma proteins, which mimic the final pathway of the coagulation cascade. Its application to stimulate the healing process has been a topic of debate in the literature. The use of fibrin sealants in phonosurgery has been empirical; there have been no studies that investigate the action of fibrin sealant in Reinke's space.
  
  
  OBJECTIVE
  To evaluate the effect of fibrin glue in healing of the vocal folds of pigs after surgical manipulation.
  
  
  METHODS
  This was a prospective and experimental study. Six animals had both vocal folds incised. Sealant was applied in one of them; the other served as a control. After three months, the animals were sacrificed and a collagen count was carried out.
  
  
  RESULTS
  The side on which glue was applied had an average of 27.8% against 20.4% of the side without glue.
  
  
  CONCLUSIONS
  The collagen concentration in the samples where the fibrin sealant was applied was significantly higher compared to samples without glue. Thus, the presence of a fibrin sealant stimulates fibrogenesis in this tissue.
authors.affiliation: Medical Science School, São Paulo Holy House-Santa Casa.
authors.forename: Karla Palma
authors.initials: KP
authors.lastname: Portes
authors.forename: André de Campos
authors.initials: Ade C
authors.lastname: Duprat
authors.forename: Carmen Lucia Penteado
authors.initials: CL
authors.lastname: Lancellotti
authors.forename: Leonardo
authors.initials: L
authors.lastname: Silva
authors.forename: Flávia Coelho de
authors.initials: FC
authors.lastname: Souza
mesh_terms: D000818:Animals; D003094:Collagen / Q000032:analysis*; D015718:Fibrin Tissue Adhesive / Q000494:pharmacology*; D011446:Prospective Studies; D013552:Swine; D013556:Swine, Miniature; D014014:Tissue Adhesives / Q000494:pharmacology*; D014827:Vocal Cords / Q000601:surgery*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives; D003094:Collagen