title: Peripheral human γδ T cells control growth of both avirulent and highly virulent strains of Francisella tularensis in vitro.
abstract: In this paper we evaluate the role of human γδ T cells in control of Francisella tularensis infection. Using an in vitro model of infection, a reduction in bacterial numbers was detected in the presence of human γδ T cells for both attenuated LVS and virulent SCHU S4 strains of F. tularensis. Antibody neutralisation of IFN-γ caused an increase in survival of F. tularensis LVS suggesting that γδ T cell-mediated control of F. tularensis infection is partially mediated by IFN-γ.
authors.affiliation: Biomedical Sciences Dept, Dstl, Porton Down, Salisbury SP4 0JQ, UK. carowland@dstl.gov.uk
authors.forename: Caroline A
authors.initials: CA
authors.lastname: Rowland
authors.forename: M Gill
authors.initials: MG
authors.lastname: Hartley
authors.forename: Helen
authors.initials: H
authors.lastname: Flick-Smith
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Laws
authors.forename: Jim E
authors.initials: JE
authors.lastname: Eyles
authors.forename: Petra C F
authors.initials: PC
authors.lastname: Oyston
mesh_terms: D002478:Cells, Cultured; D005604:Francisella tularensis / Q000145:classification / Q000276:immunology* / Q000472:pathogenicity*; D006801:Humans; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000276:immunology*; D017471:Receptors, Interferon / Q000378:metabolism; D013045:Species Specificity; D013601:T-Lymphocytes / Q000276:immunology*; D014406:Tularemia / Q000276:immunology* / Q000382:microbiology*; D000096743:Interferon gamma Receptor
chemical_list: D016692:Receptors, Antigen, T-Cell, gamma-delta; D017471:Receptors, Interferon; D000096743:Interferon gamma Receptor