title: Verrulactones A and B, new inhibitors of Staphylococcus aureus enoyl-ACP reductase produced by Penicillium verruculosum F375.
abstract: New dimeric compounds of alternariol class, verrulactones A and B, were isolated from a culture broth of the fungal strain Penicillium verruculosum F375 and their structure were established by various spectral analysis. Verrulactones A and B strongly inhibited Staphylococcus aureus enoyl-ACP reductase with IC(50) of 0.92 and 1.41 μM, respectively, and also showed antibacterial activity against S. aureus and MRSA with MICs of 8 and 16 μg/mL, respectively.
authors.affiliation: Korea Research Institute of Bioscience and Biotechnology, PO Box 115, Yusong, Daejeon 305-806, Republic of Korea.
authors.forename: Nyung
authors.initials: N
authors.lastname: Kim
authors.forename: Mi-Jin
authors.initials: MJ
authors.lastname: Sohn
authors.forename: Chang-Jin
authors.initials: CJ
authors.lastname: Kim
authors.forename: Ho Jeong
authors.initials: HJ
authors.lastname: Kwon
authors.forename: Won-Gon
authors.initials: WG
authors.lastname: Kim
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D003470:Culture Media; D050753:Enoyl-(Acyl-Carrier-Protein) Reductase (NADH) / Q000037:antagonists & inhibitors* / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D050296:Microbial Viability / Q000187:drug effects; D010407:Penicillium / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D003470:Culture Media; D004791:Enzyme Inhibitors; D006576:Heterocyclic Compounds, 4 or More Rings; D007783:Lactones; C573360:verrulactone A; C573359:verrulactone B; D050753:Enoyl-(Acyl-Carrier-Protein) Reductase (NADH)