title: Asparaginase-associated pancreatitis in a dog.
abstract: A dog with lymphosarcoma was evaluated for vomiting, lethargy, and abdominal pain 48 h after treatment with L-asparaginase. Based on drug administration, clinical signs, bloodwork, and elevated canine pancreatic lipase immunoreactivity, L-asparaginase-associated pancreatitis was diagnosed. This is an acknowledged toxicity; however, its pathophysiology and incidence rate in veterinary patients are unknown and sparsely documented.
authors.affiliation: Department of Clinical Sciences, College of Veterinary Medicine, Auburn University Hoerlein Hall, Auburn, Alabama 36849, USA. ses0034@auburn.edu
authors.forename: Stephanie E
authors.initials: SE
authors.lastname: Schleis
authors.forename: Scott A
authors.initials: SA
authors.lastname: Rizzo
authors.forename: Jeffery C
authors.initials: JC
authors.lastname: Phillips
authors.forename: Amy K
authors.initials: AK
authors.lastname: LeBlanc
mesh_terms: D000818:Animals; D001215:Asparaginase / Q000009:adverse effects* / Q000627:therapeutic use; D004283:Dog Diseases / Q000139:chemically induced*; D004285:Dogs; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy / Q000662:veterinary; D008297:Male; D010195:Pancreatitis / Q000139:chemically induced / Q000662:veterinary*
chemical_list: D001215:Asparaginase