title: Effects of systemic ornidazole, systemic and local compound ornidazole and pefloxacin mesylate on experimental periodontitis in rats.
abstract: BACKGROUND
  The purpose of the current study is to evaluate the effects of systemic ornidazole (SO) and systemic and local compound ornidazole and pefloxacin mesylate (SCOPM/LCOMP) on the inflammatory response associated with rat experimental chronic periodontitis (ECP) in sites with subgingival debridement.
  
  
  METHODS
  Periodontitis was induced in male Sprague-Dawley rats by placing a thin steel ligature around the upper first molars and inoculating them with Porphyromonas gingivalis 381. After the successful induction of the rat ECP, the periodontitis rats were randomly divided into 3 different combined treatment groups: (A) SO with scaling and root planing (SRP); (B) SCOMP with SRP; and (C) LCOMP with SRP. After 2 weeks the effects of the treatments were evaluated based on gingivitis, plaque index, probing pocket depth, aspartate aminotransferase, alveolar bone loss, and hematoxylin-eosin staining of the region around the first molars.
  
  
  RESULTS
  After treatment, comparison with ECP was performed. The mean percentage reductions of SBI in SO, SCOPM, and LCOPM were 27.73%, 33.61%, and 58.82%, respectively. Those of PI were 33.20%, 42.80%, and 60.00%; those of PPD were 48.66%, 55.70%, and 72.48%; those of GCF-AST were 41.64%, 49.03%, and 66.42%; and those of ABL were 41.19%, 43.63%, and 54.47%, respectively. The inflammatory score of H&E showed median scores of 2.5, 1.75, 1.63, and 0.95 for ECP, SO, SCOMP, and LCOMP, respectively. All 3 treatment groups exhibited significantly reduced inflammation indicators (P<0.05). Of the 3, group C was the most effective (P<0.05).
  
  
  CONCLUSIONS
  Although all the combined treatment groups responded to therapy with significant resolution of the infection, adjunctive LCOMP therapy is more effective for periodontitis.
authors.affiliation: Department of Stomatology, Research Institute of Surgery and Daping Hospital, 3rd Military Medical University, Chongqing, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Liu
authors.forename: Nan
authors.initials: N
authors.lastname: Li
authors.forename: Ning
authors.initials: N
authors.lastname: Liu
authors.forename: Xia
authors.initials: X
authors.lastname: Zhou
authors.forename: Zheng-mou
authors.initials: ZM
authors.lastname: Dong
authors.forename: Xiu-jie
authors.initials: XJ
authors.lastname: Wen
authors.forename: Lu-chuan
authors.initials: LC
authors.lastname: Liu
mesh_terms: D000818:Animals; D008297:Male; D009950:Ornidazole / Q000008:administration & dosage / Q000627:therapeutic use*; D015366:Pefloxacin / Q000008:administration & dosage / Q000627:therapeutic use*; D010518:Periodontitis / Q000188:drug therapy* / Q000382:microbiology; D016966:Porphyromonas gingivalis / Q000472:pathogenicity; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D015366:Pefloxacin; D009950:Ornidazole