title: [Responses of neurons of the solitary tract nucleus to noxious colorectal distension in rats].
abstract: In experiments on anaesthetized rats, the neuronal mechanisms underlying processing of the nociceptive information from the colon within the nucleus of the solitary tract were studied. In addition, the role of nitric oxide in these processes was estimated. Analysis of changes in c-fos expression revealed that nociceptive colorectal distension (CRD) resulted in activation of neurons mainly in the medial, commissural, parvicellular and dorsomedial subnuclei of the solitary tract nucleus. Non-noxious CRD evoked in these subdivisions weak phasic excitatory neuronal responses. Under noxious CRD, neurons with phasic (58%) and tonic (42%) responses were revealed. The phasic neuron responses were significantly enhanced in comparison with non-noxious CRD. Inhibition of the neuronal NO-syntheses resulted in significant decrease of neuron responses to noxious CRD and the number of cells with tonic reactions. Therefore, neurons with tonic responses may be directly related to NO-depended processing ofnociceptive information from colon.
authors.forename: S S
authors.initials: SS
authors.lastname: Pantellev
authors.forename: A A
authors.initials: AA
authors.lastname: Martseva
authors.forename: O A
authors.initials: OA
authors.lastname: Liubashina
mesh_terms: D000818:Animals; D003106:Colon / Q000294:innervation* / Q000378:metabolism; D005071:Evoked Potentials / Q000502:physiology*; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D009569:Nitric Oxide; D059225:Nociception / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D012007:Rectum / Q000294:innervation* / Q000378:metabolism; D017552:Solitary Nucleus / Q000166:cytology / Q000378:metabolism*
chemical_list: D009569:Nitric Oxide