title: Nuclease activity via self-activation and anticancer activity of a mononuclear copper(II) complex: novel role of the tertiary butyl group in the ligand frame.
abstract: The copper complex [Cu((t)BuPhimp)(Cl)] (1) derived from tridentate ligand (t)BuPhimpH having N(2)O donors was synthesized, and its molecular structure was determined. A phenoxyl radical complex was generated in solution at room temperature using Ce(IV). The nuclease and anticancer activities of 1 were investigated. The roles of the tert-butyl group and singlet oxygen in the DNA cleavage activity were also discussed.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Roorkee, Roorkee 247667, India. ghoshfcy@iitr.ernet.in
authors.forename: Kaushik
authors.initials: K
authors.lastname: Ghosh
authors.forename: Pramod
authors.initials: P
authors.lastname: Kumar
authors.forename: Varun
authors.initials: V
authors.lastname: Mohan
authors.forename: Udai P
authors.initials: UP
authors.lastname: Singh
authors.forename: Sahba
authors.initials: S
authors.lastname: Kasiri
authors.forename: Subhrangsu S
authors.initials: SS
authors.lastname: Mandal
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003300:Copper / Q000494:pharmacology*; D004720:Endonucleases / Q000378:metabolism*; D006801:Humans; D020128:Inhibitory Concentration 50; D008024:Ligands
chemical_list: D000970:Antineoplastic Agents; D008024:Ligands; D003300:Copper; D004720:Endonucleases