title: Mumps vaccine effectiveness in primary schools and households, the Netherlands, 2008.
abstract: To estimate the mumps vaccine effectiveness (VE) during a large genotype D mumps outbreak, we conducted a cross-sectional study in eight primary schools and associated households in the Netherlands. Questionnaires were used to collect information on the occurrence of mumps. Multivariate analyses were used to estimate VE. Among schoolchildren we estimated the VE against mumps. Among household contacts where the schoolchild was the index case we estimated the VE against mumps and against mumps infectiousness. In total 1175 children and 2281 household contacts participated in the study. The mumps attack rate among schoolchildren was 17%. The mumps VE in schoolchildren was 92% [95% confidence interval (CI) 83-96%] and 93% [85-97%] for one and two doses of the measles, mumps, rubella (MMR) vaccine, respectively. The adjusted mumps VE among household contacts was 67% [65-95%] and 11% [-4 to 88%] against mumps and mumps infectiousness, respectively. Our study indicates that the mumps component of the MMR vaccine offered adequate protection against mumps among schoolchildren. The relatively low VE among household contacts is of concern.
authors.affiliation: Centre for Infectious Disease Control, National Institute for Public Health and the Environment, Bilthoven, the Netherlands. bianca.snijders@rivm.nl
authors.forename: Bianca E P
authors.initials: BE
authors.lastname: Snijders
authors.forename: Alies
authors.initials: A
authors.lastname: van Lier
authors.forename: Jan
authors.initials: J
authors.lastname: van de Kassteele
authors.forename: Ewout B
authors.initials: EB
authors.lastname: Fanoy
authors.forename: Wilhelmina L M
authors.initials: WL
authors.lastname: Ruijs
authors.forename: Folkwin
authors.initials: F
authors.lastname: Hulshof
authors.forename: Annet
authors.initials: A
authors.lastname: Blauwhof
authors.forename: Maarten
authors.initials: M
authors.lastname: Schipper
authors.forename: Rob
authors.initials: R
authors.lastname: van Binnendijk
authors.forename: Hein J
authors.initials: HJ
authors.lastname: Boot
authors.forename: Hester E
authors.initials: HE
authors.lastname: de Melker
authors.forename: Susan J M
authors.initials: SJ
authors.lastname: Hahné
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D004196:Disease Outbreaks; D005191:Family Characteristics; D005260:Female; D006801:Humans; D008297:Male; D009107:Mumps / Q000453:epidemiology* / Q000517:prevention & control*; D009108:Mumps Vaccine / Q000008:administration & dosage / Q000276:immunology*; D009426:Netherlands / Q000453:epidemiology; D015995:Prevalence; D012574:Schools; D011795:Surveys and Questionnaires
chemical_list: D009108:Mumps Vaccine