title: [Pathogenic aspects of influenza during the epidemics caused by A/H1N1v virus in 2009-2010 according autopsy data].
abstract: The paper is based upon the results of clinic-pathological and virological correlations in 29 lethal cases of influenza in Saint-Petersburg and Leningrad region during the epidemics 2009/2010. Immunohistochemical analysis of lungs, heart and brain using monoclonal sera to HA and HP proteins of influenza virus, virological and morphological analysis of experimental influenza in mice infected by A/WSN/33 (HIN1) and A/California/07/09 (H1N1) viruses had been carried out. In the majority of investigated strains was proved the amino acid mutation with replacement D222G. The replication of virus was demonstrated at the late stages of diseases, but the desquamation of respiratory epithelium and cytoproliferative weren't found out. Besides the "influenza cells", previously described by A. V Zinserling the cells with enlarge light nuclei were observed. Patients with influenza died from respiratory distress syndrome with minimal bacterial infection. We've established that H1N1 virus not only damages the cells of respiratory epithelium and alveolar macrophages but it can injure endothelium of different organs and neuroglia. The questions which have to be discussed are listed.
authors.forename: V A
authors.initials: VA
authors.lastname: Tsinzerling
authors.forename: S L
authors.initials: SL
authors.lastname: Vorob'ev
authors.forename: V V
authors.initials: VV
authors.lastname: Zarubaev
authors.forename: S V
authors.initials: SV
authors.lastname: Beliavskaia
authors.forename: E V
authors.initials: EV
authors.lastname: Esaulenko
authors.forename: I V
authors.initials: IV
authors.lastname: Grigor'eva
authors.forename: V A
authors.initials: VA
authors.lastname: Dedov
authors.forename: M P
authors.initials: MP
authors.lastname: Grudinin
authors.forename: Zh V
authors.initials: ZhV
authors.lastname: Buzitskaia
authors.forename: M M
authors.initials: MM
authors.lastname: Pisareva
authors.forename: A R
authors.initials: AR
authors.lastname: Prochukhanova
authors.forename: M A
authors.initials: MA
authors.lastname: Stukova
authors.forename: A A
authors.initials: AA
authors.lastname: Azarenok
authors.forename: I N
authors.initials: IN
authors.lastname: Zhilinskaia
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D001344:Autopsy; D001921:Brain / Q000473:pathology* / Q000821:virology; D005260:Female; D006321:Heart / Q000821:virology; D006801:Humans; D007150:Immunohistochemistry; D053118:Influenza A Virus, H1N1 Subtype / Q000235:genetics / Q000302:isolation & purification* / Q000502:physiology; D007251:Influenza, Human / Q000401:mortality / Q000473:pathology / Q000821:virology; D008168:Lung / Q000473:pathology* / Q000821:virology; D008297:Male; D051379:Mice; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*; D016133:Polymerase Chain Reaction; D012128:Respiratory Distress Syndrome / Q000209:etiology / Q000401:mortality / Q000473:pathology / Q000821:virology; D012426:Russia / Q000453:epidemiology; D014779:Virus Replication; D055815:Young Adult