title: Individualization of cancer treatment from radiotherapy perspective.
abstract: Radiotherapy is today used in about 50% of all cancer patients, often in multidisciplinary approaches. With major advance in radiotherapy techniques, increasing knowledge on tumor genetics and biology and the continuous introduction of specifically targeted drugs into combined radio-oncological treatment schedules, individualization of radiotherapy is of high priority to further improve treatment outcomes, i.e. to increase long-term tumor cure and/or to reduce chronic treatment toxicity. This review gives an overview on the importance of predictive biomarkers for the field of radiation oncology. The current status of knowledge on potential biomarkers of tumor hypoxia, tumor cell metabolism, DNA repair, cancer stem cells and biomarkers for combining radiotherapy with inhibition of the epidermal growth factor receptor using monoclonal antibodies is described.
authors.affiliation: Department of Radiation Oncology, OncoRay-National Center for Radiation Research in Oncology, University Hospital and Medical Faculty Carl Gustav Carus, Technische Universität Dresden, Germany.
authors.forename: Ala
authors.initials: A
authors.lastname: Yaromina
authors.forename: Mechthild
authors.initials: M
authors.lastname: Krause
authors.forename: Michael
authors.initials: M
authors.lastname: Baumann
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D004260:DNA Repair; D006801:Humans; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000532:radiotherapy*; D014411:Neoplastic Stem Cells / Q000473:pathology; D049268:Positron-Emission Tomography; D057285:Precision Medicine
chemical_list: D014408:Biomarkers, Tumor