title: Positional requirements for the stimulation of mRNA nuclear export by ALREX-promoting elements.
abstract: The majority of vertebrate mRNAs that encode secreted, membrane-bound or mitochondrial proteins contain elements at the 5' end of the ORF that activate an alternative mRNA nuclear export (ALREX) pathway. Here we demonstrate that these elements promote efficient export and proper cytoplasmic localization only when they are found at the 5' end of the transcript.
authors.affiliation: University of Toronto, Department of Biochemistry, 1 King's College Circle, Medical Sciences Building Room 5242, Toronto, ON M5S 1A8, Canada. alex.palazzo@utoronto.ca
authors.forename: Stefan P
authors.initials: SP
authors.lastname: Tarnawsky
authors.forename: Alexander F
authors.initials: AF
authors.lastname: Palazzo
mesh_terms: D021581:Active Transport, Cell Nucleus / Q000235:genetics*; D000818:Animals; D045744:Cell Line, Tumor; D002467:Cell Nucleus / Q000235:genetics / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism; D004330:Drosophila; D005091:Exons; D017930:Genes, Reporter; D005818:Genetic Engineering; D006801:Humans; D051379:Mice; D016366:Open Reading Frames; D010957:Plasmids; D034443:RNA Transport / Q000235:genetics*; D012333:RNA, Messenger / Q000737:chemistry / Q000235:genetics*
chemical_list: D012333:RNA, Messenger