title: Total synthesis of 6'-hydroxyjusticidin A.
abstract: The first total synthesis of 6'-hydroxyjusticidin A, isolated from Justicia procumbens L. with good inhibitory activity against cancer cells, has been accomplished. The structure was confirmed by ¹H NMR, ¹³C NMR, and HR-ESI-MS. The key steps involved a Diels-Alder cycloaddition reaction and a reduction in NaBH₄.
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Department of New Drug Research and Development, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Xiong
authors.forename: Ming-Gang
authors.initials: MG
authors.lastname: Bi
authors.forename: Song
authors.initials: S
authors.lastname: Wu
authors.forename: Yuan-Feng
authors.initials: YF
authors.lastname: Tong
mesh_terms: D027901:Acanthaceae / Q000737:chemistry; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004148:Dioxolanes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D017705:Lignans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D013237:Stereoisomerism
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004148:Dioxolanes; D017705:Lignans; C571611:6'-hydroxyjusticidin A