title: Angiotensin-converting enzyme I/D polymorphism is not associated with type 2 diabetes in a Chinese population.
abstract: OBJECTIVE
  A role for the angiotensin-converting enzyme (ACE) gene has been suggested in the aetiology of type 2 diabetes (T2DM). However, results have been inconsistent. In this study, we performed a meta-analysis to further clarify the association between ACE I/D polymorphism and T2DM risk in a Chinese population.
  
  
  METHODS
  PubMed, EMBASE, CNKI and Wan Fang Data were searched for eligible studies. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a fixed-effects model or random-effects model.
  
  
  RESULTS
  : A total of 41 studies (4708 cases and 5368 controls) for the association between ACE I/D polymorphism and T2DM in a Chinese population were identified. The pooled ORs for the association between ACE I/D polymorphism and T2DM risk were not statistically significant under all genetic models (co-dominant model: DD vs. II: OR = 1.17, 95% CI 0.97-1.42 and ID vs. II: OR = 1.01, 95% CI 0.93-1.10; dominant model: OR = 1.06, 95% CI 0.94-1.19; multiplicative model: OR = 1.08, 95% CI 0.98-1.18). Although a marginally significant association was observed under a recessive model (OR = 1.17, 95% CI 1.00-1.36), robustness of this estimate could not be established under additional sensitivity analyses.
  
  
  CONCLUSIONS
  : The meta-analysis presented in this study indicated that ACE I/D polymorphism may not be associated with the risk of T2DM in the Chinese population.
authors.affiliation: Department of Endocrinology, Linyin People's Hospital, China.
authors.forename: Donghao
authors.initials: D
authors.lastname: Zhou
authors.forename: Rikje
authors.initials: R
authors.lastname: Ruiter
authors.forename: Jingling
authors.initials: J
authors.lastname: Zhang
authors.forename: Ming'ai
authors.initials: M
authors.lastname: Zhou
authors.forename: Hongjun
authors.initials: H
authors.lastname: Liu
authors.forename: Weidong
authors.initials: W
authors.lastname: Liu
authors.forename: Shengxiang
authors.initials: S
authors.lastname: Wang
mesh_terms: D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D003924:Diabetes Mellitus, Type 2 / Q000201:enzymology* / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D054643:INDEL Mutation / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D017594:Publication Bias
chemical_list: C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A