title: Cystatin C levels in patients with dipper and nondipper hypertension.
abstract: OBJECTIVE
  Subjects with nondipper hypertension carry a higher risk of cardiovascular events than their normotensive counterparts. The present study was designed to investigate cystatin C levels in patients with dipper and nondipper hypertension.
  
  
  METHODS
  Eighty-eight consecutive patients who had been treated with antihypertensive drugs for at least 6 months were included in the study. Dipping and nondipping patterns were detected with ambulatory blood pressure monitoring. Clinical, laboratory, and ambulatory blood pressure monitoring data of patient groups with nondipper and dipper hypertension were compared.
  
  
  RESULTS
  Patients in the nondipper group were older than those in the dipper group. Serum cystatin C level was higher in the patients in the nondipper group. Cystatin C was negatively correlated with the rate of systolic blood pressure fall at night (r = -0.41; P < 0.001). Linear regression analyses revealed that only cystatin C level was a significant correlate of nocturnal systolic blood pressure decrease. Logistic regression analyses also showed that cystatin C was an independent predictor of nondipping pattern (odds ratio, 3.586; 95% confidence interval, 1.432-8.98; P = 0.006]).
  
  
  CONCLUSIONS
  The present study showed that cystatin C is higher in patients with nondipper hypertension patients.
authors.affiliation: Department of Cardiology, Medicine Faculty, Duzce University, Duzce, Turkey.
authors.forename: Serkan
authors.initials: S
authors.lastname: Ordu
authors.forename: Hakan
authors.initials: H
authors.lastname: Ozhan
authors.forename: Recai
authors.initials: R
authors.lastname: Alemdar
authors.forename: Hayriye
authors.initials: H
authors.lastname: Yildirim
authors.forename: Adem
authors.initials: A
authors.lastname: Gungor
authors.forename: Sabri Onur
authors.initials: SO
authors.lastname: Caglar
authors.forename: Mesut
authors.initials: M
authors.lastname: Aydin
authors.forename: Serkan
authors.initials: S
authors.lastname: Bulur
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000494:pharmacology / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D018660:Blood Pressure Monitoring, Ambulatory / Q000379:methods; D055316:Cystatin C / Q000097:blood*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D008875:Middle Aged
chemical_list: D000959:Antihypertensive Agents; D015415:Biomarkers; D055316:Cystatin C