title: Framingham risk-based survival of non-small-cell lung cancer.
abstract: This study was undertaken to determine whether the Framingham cardiovascular risk prediction model can identify patients who will have reduced 5-year survival after resection for primary lung cancer. The Framingham risk model for predicting cardiovascular death rates in a 5-year period was calculated for 1,981 patients undergoing resection for non-small-cell lung cancer. Receiver operator curve analysis was performed to determine a cutoff with regard to Framingham risk, and this was utilized to construct Kaplan-Meier survival curves for stages I, II, and III. Cox regression analysis was used to determine factors significantly affecting long-term survival. The Framingham risk model predicted that 0.015% to 26.7 % (mean, 5.2%) of our patients would die over a 5-year period. Univariate analysis revealed the Framingham score as being significant for stages I and II, but not III. Cox regression analysis demonstrated age, body mass index, pneumonectomy, stage I, stage III, stage IV, and Framingham score were all significant determinants of 5-year survival. Framingham-based cardiovascular risk prediction in patients undergoing resection for non-small-cell lung cancer stages I and II defined a group with significantly worse 5-year survival.
authors.affiliation: Liverpool Heart and Chest Hospital, Liverpool, UK. mike.poullis@lhch.nhs.uk
authors.forename: Michael
authors.initials: M
authors.lastname: Poullis
authors.forename: James
authors.initials: J
authors.lastname: McShane
authors.forename: Matthew
authors.initials: M
authors.lastname: Shaw
authors.forename: Richard
authors.initials: R
authors.lastname: Page
authors.forename: Michael
authors.initials: M
authors.lastname: Shackcloth
authors.forename: Neeraj
authors.initials: N
authors.lastname: Mediratta
mesh_terms: D000368:Aged; D002289:Carcinoma, Non-Small-Cell Lung / Q000150:complications / Q000401:mortality* / Q000601:surgery; D002318:Cardiovascular Diseases / Q000150:complications / Q000401:mortality*; D002423:Cause of Death; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000150:complications / Q000401:mortality* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011013:Pneumonectomy / Q000009:adverse effects / Q000401:mortality; D011379:Prognosis; D012044:Regression Analysis; D018570:Risk Assessment; D012307:Risk Factors; D016896:Treatment Outcome