title: Circulatory microRNA-145 expression is increased in cerebral ischemia.
abstract: Cerebral  ischemia or ischemic stroke is mainly attributed to vascular and circulation  disorders. Among protein biomarkers, RNA profiles have also been identified as  markers of ischemic stroke. MicroRNA-145 expression is ostensibly recognized as  marker and modulator of vascular smooth muscle cell phenotype; however,  expression levels in ischemic stroke had not been investigated. Employing  real-time quantitative PCR, we examined the expression profile of circulatory  microRNA-145 in healthy control subjects (N = 14) and ischemic stroke patients  (N = 32). Circulatory microRNA-145 expression was significantly higher in  ischemic stroke patients than in control subjects. This demonstrates that  hemostatic mechanisms are affected by ischemic stroke. We conclude that  circulating microRNA-145 has potential as a biomarker for ischemic stroke.
authors.affiliation: Department of Molecular Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia. mr.dennisgan@gmail.com
authors.forename: C S
authors.initials: CS
authors.lastname: Gan
authors.forename: C W
authors.initials: CW
authors.lastname: Wang
authors.forename: K S
authors.initials: KS
authors.lastname: Tan
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers; D002545:Brain Ischemia / Q000235:genetics* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000097:blood* / Q000235:genetics / Q000378:metabolism*; D008875:Middle Aged; D020411:Oligonucleotide Array Sequence Analysis; D012333:RNA, Messenger / Q000378:metabolism; D020521:Stroke / Q000235:genetics* / Q000503:physiopathology; D055815:Young Adult
chemical_list: D015415:Biomarkers; C541010:MIRN145 microRNA, human; D035683:MicroRNAs; D012333:RNA, Messenger