title: The prevalence of CD33 and MS4A6A variant in Chinese Han population with Alzheimer's disease.
abstract: CD33 and MS4A6A genes play potential key roles in the pathogenesis of Alzheimer's disease (AD). One recent genome-wide association study has revealed that the rs3865444 polymorphism in the CD33 gene and rs610932 polymorphism in the MS4A6A gene are associated with susceptibility to AD in Caucasians. To evaluate the relationship between the polymorphism of the CD33, MS4A6A gene and AD in the ethnic Chinese Han, we conducted a case-control study (n = 383, age > 54) to determine the prevalence of single-nucleotide polymorphism of two genes in patients with AD in Chinese population of Mainland, and clarified whether these polymorphisms are risk factors for AD. The prevalence of the allele (T) in the rs3865444 polymorphism of the CD33 gene and allele (C) in rs610932 polymorphism of the MS4A6A gene was significantly different in AD patients and control subjects (P < 0.001, respectively), and the results were not influenced by age, gender, or APOE status. Our data revealed the allele (T) of the rs3865444 polymorphism of the CD33 gene and the allele (C) of the rs610932 polymorphism of the MS4A6A gene may contribute to AD risk in the Chinese Han population.
authors.affiliation: Department of Neurology and Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
authors.forename: Yu-Lei
authors.initials: YL
authors.lastname: Deng
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Liu
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Hui-Dong
authors.initials: HD
authors.lastname: Tang
authors.forename: Ru-Jing
authors.initials: RJ
authors.lastname: Ren
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
authors.forename: Jian-Fang
authors.initials: JF
authors.lastname: Ma
authors.forename: Li-Ling
authors.initials: LL
authors.lastname: Wang
authors.forename: Jun-Peng
authors.initials: JP
authors.lastname: Zhuang
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
authors.forename: Sheng-Di
authors.initials: SD
authors.lastname: Chen
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000208:ethnology* / Q000235:genetics*; D015703:Antigens, CD / Q000235:genetics*; D015214:Antigens, Differentiation, Myelomonocytic / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D017422:Sequence Analysis, DNA; D063268:Sialic Acid Binding Ig-like Lectin 3
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; C571163:CD33 protein, human; C574492:MS4A6A protein, human; D008565:Membrane Proteins; D063268:Sialic Acid Binding Ig-like Lectin 3