title: Potassium iodide capsule treatment of feline sporotrichosis.
abstract: Sporotrichosis is a mycosis caused by Sporothrix schenckii. The most affected animal is the cat; it has played an important role in the zoonotic transmission of this disease, especially in Rio de Janeiro, Brazil, since 1998. In order to evaluate the treatment of feline sporotrichosis with potassium iodide, an observational cohort was conducted in 48 cats with sporotrichosis at Instituto de Pesquisa Clínica Evandro Chagas, Fiocruz. All cats received potassium iodide capsules, 2.5 mg/kg to 20 mg/kg q24h. The cure rate was 47.9%, treatment failure was 37.5%, treatment abandonment was 10.4% and death was 4.2%. Clinical adverse effects were observed in 52.1% of the cases. Thirteen cats had a mild increase in hepatic transaminase levels during the treatment, six of them presented clinical signs suggestive of hepatotoxicity. Compared to previous studies with itraconazole and iodide in saturated solution, potassium iodide capsules are an alternative for feline sporotrichosis treatment.
authors.affiliation: Laboratory of Clinical Research on Dermatozoonosis in Domestic Animals, Evandro Chagas Clinical Research Institute/Oswaldo Cruz Foundation, Rio de Janeiro, Brazil. ericaguerino@gmail.com
authors.forename: Erica G
authors.initials: EG
authors.lastname: Reis
authors.forename: Isabella D F
authors.initials: ID
authors.lastname: Gremião
authors.forename: Amanda A B
authors.initials: AA
authors.lastname: Kitada
authors.forename: Raphael F D B
authors.initials: RF
authors.lastname: Rocha
authors.forename: Verônica S P
authors.initials: VS
authors.lastname: Castro
authors.forename: Mônica B L
authors.initials: MB
authors.lastname: Barros
authors.forename: Rodrigo C
authors.initials: RC
authors.lastname: Menezes
authors.forename: Sandro A
authors.initials: SA
authors.lastname: Pereira
authors.forename: Tânia M P
authors.initials: TM
authors.lastname: Schubach
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002214:Capsules; D002371:Cat Diseases / Q000188:drug therapy* / Q000382:microbiology; D002415:Cats; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D008297:Male; D011193:Potassium Iodide / Q000009:adverse effects / Q000627:therapeutic use*; D013174:Sporotrichosis / Q000188:drug therapy / Q000662:veterinary*; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D002214:Capsules; D011193:Potassium Iodide