title: Molecular symmetry and biological activities of new symmetrical tris(2-aminoethyl)amine derivatives.
abstract: In terms of molecular symmetry and bioactivity, new C3- and CS-symmetrical derivatives based on the tris(2-aminoethyl)amine scaffold were designed and synthesized. The synthesized compounds were evaluated for antiviral activity with herpes simplex virus type 1 (HSV-1) by a plaque reduction assay and for cytotoxic activity with Vero cells. Most of the compounds showed no significant anti-HSV-1 activity, but some of the symmetrical derivatives showed high levels of cytotoxic activitiy.
authors.affiliation: Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan.
authors.forename: Nobuko
authors.initials: N
authors.lastname: Mibu
authors.forename: Kazumi
authors.initials: K
authors.lastname: Yokomizo
authors.forename: Wataru
authors.initials: W
authors.lastname: Uchida
authors.forename: Satoshi
authors.initials: S
authors.lastname: Takemura
authors.forename: Jianrong
authors.initials: J
authors.lastname: Zhou
authors.forename: Hatsumi
authors.initials: H
authors.lastname: Aki
authors.forename: Takeshi
authors.initials: T
authors.lastname: Miyata
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Sumoto
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D005029:Ethylenediamines / Q000138:chemical synthesis* / Q000494:pharmacology*; D018259:Herpesvirus 1, Human / Q000187:drug effects / Q000254:growth & development; D014709:Vero Cells; D010948:Viral Plaque Assay / Q000379:methods
chemical_list: D000998:Antiviral Agents; D005029:Ethylenediamines; C099539:tris(2-aminoethyl)amine