title: RNA-Puzzles: a CASP-like evaluation of RNA three-dimensional structure prediction.
abstract: We report the results of a first, collective, blind experiment in RNA three-dimensional (3D) structure prediction, encompassing three prediction puzzles. The goals are to assess the leading edge of RNA structure prediction techniques; compare existing methods and tools; and evaluate their relative strengths, weaknesses, and limitations in terms of sequence length and structural complexity. The results should give potential users insight into the suitability of available methods for different applications and facilitate efforts in the RNA structure prediction community in ongoing efforts to improve prediction tools. We also report the creation of an automated evaluation pipeline to facilitate the analysis of future RNA structure prediction exercises.
authors.affiliation: Architecture et Réactivité de l'ARN, Université de Strasbourg, IBMC-CNRS, F-67084 Strasbourg, France.
authors.forename: José Almeida
authors.initials: JA
authors.lastname: Cruz
authors.forename: Marc-Frédérick
authors.initials: MF
authors.lastname: Blanchet
authors.forename: Michal
authors.initials: M
authors.lastname: Boniecki
authors.forename: Janusz M
authors.initials: JM
authors.lastname: Bujnicki
authors.forename: Shi-Jie
authors.initials: SJ
authors.lastname: Chen
authors.forename: Song
authors.initials: S
authors.lastname: Cao
authors.forename: Rhiju
authors.initials: R
authors.lastname: Das
authors.forename: Feng
authors.initials: F
authors.lastname: Ding
authors.forename: Nikolay V
authors.initials: NV
authors.lastname: Dokholyan
authors.forename: Samuel Coulbourn
authors.initials: SC
authors.lastname: Flores
authors.forename: Lili
authors.initials: L
authors.lastname: Huang
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Lavender
authors.forename: Véronique
authors.initials: V
authors.lastname: Lisi
authors.forename: François
authors.initials: F
authors.lastname: Major
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Mikolajczak
authors.forename: Dinshaw J
authors.initials: DJ
authors.lastname: Patel
authors.forename: Anna
authors.initials: A
authors.lastname: Philips
authors.forename: Tomasz
authors.initials: T
authors.lastname: Puton
authors.forename: John
authors.initials: J
authors.lastname: Santalucia
authors.forename: Fredrick
authors.initials: F
authors.lastname: Sijenyi
authors.forename: Thomas
authors.initials: T
authors.lastname: Hermann
authors.forename: Kristian
authors.initials: K
authors.lastname: Rother
authors.forename: Magdalena
authors.initials: M
authors.lastname: Rother
authors.forename: Alexander
authors.initials: A
authors.lastname: Serganov
authors.forename: Marcin
authors.initials: M
authors.lastname: Skorupski
authors.forename: Tomasz
authors.initials: T
authors.lastname: Soltysinski
authors.forename: Parin
authors.initials: P
authors.lastname: Sripakdeevong
authors.forename: Irina
authors.initials: I
authors.lastname: Tuszynska
authors.forename: Kevin M
authors.initials: KM
authors.lastname: Weeks
authors.forename: Christina
authors.initials: C
authors.lastname: Waldsich
authors.forename: Michael
authors.initials: M
authors.lastname: Wildauer
authors.forename: Neocles B
authors.initials: NB
authors.lastname: Leontis
authors.forename: Eric
authors.initials: E
authors.lastname: Westhof
mesh_terms: D001483:Base Sequence; D019281:Dimerization; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D012313:RNA / Q000737:chemistry*
chemical_list: D012313:RNA