title: Radiofrequency ablation associated to mucosal resection in the oesophagus: experience in a single centre.
abstract: Endoscopic resection (EMR) and radiofrequency ablation (RFA) form part of the treatment of Barrett's oesophagus (BO), dysplasia, superficial adenocarcinoma (OAC) associated with BO.
  
  
  METHODS
  Between June 2008 and April 2011, 34 patients underwent treatment with RFA (HALO system(®)), in a tertiary centre. For the study, patients were divided into two groups. Group 1 (16 patients of average 60 years old; 14 men, two women) received EMR and RFA. Group 2 (18 patients averaging 59 years age; 14 men, four women) received RFA without EMR in the year preceding the RFA.
  
  
  RESULTS
  In group 1, high grade dysplasia (HGD) was eradicated in 12 cases (92%), low grade dysplasia (LGD) in three cases (100%). Complete response occurred in nine cases (56%), partial response in 100% of cases. Mean follow-up was 15 months. In group 2, HGD was eradicated in one patient (100%), LGD in three patients (64%). A complete response was achieved in eight patients, partial response in four cases (77%). Mean follow-up was 10 months. The complication rate for groups 1 and 2 was of 18% and 10% respectively. No complication prevented completion of treatment or continued monitoring. Recurrence was evaluated to 5% in both groups.
  
  
  CONCLUSIONS
  RFA associated with EMR is feasible, offering probably better results and a very important advantage: a more complete histology before follow-up. Our results show effective treatment of BO and associated dysplasia with a low rate of complication. Nevertheless, when new techniques of BO ablation are used, the need to obtain histology before treatment should not be forgotten.
authors.affiliation: Endoscopy unit, Paoli Calmette institute, 232, boulevard Ste-Marguerite, 13009 Marseille, France. fcaillol@free.fr
authors.forename: F
authors.initials: F
authors.lastname: Caillol
authors.forename: E
authors.initials: E
authors.lastname: Bories
authors.forename: C
authors.initials: C
authors.lastname: Pesenti
authors.forename: F
authors.initials: F
authors.lastname: Poizat
authors.forename: G
authors.initials: G
authors.lastname: Monges
authors.forename: J
authors.initials: J
authors.lastname: Guiramand
authors.forename: B
authors.initials: B
authors.lastname: Esterni
authors.forename: M
authors.initials: M
authors.lastname: Giovannini
mesh_terms: D000328:Adult; D000368:Aged; D001471:Barrett Esophagus / Q000601:surgery*; D017115:Catheter Ablation; D004945:Esophagoscopy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000601:surgery