title: [Anti-thyroid antibodies in two patients with subacute dementia, ataxia, and myoclonus].
abstract: Hashimoto encephalitis (HE) is a steroid-responsive autoimmune encephalitis with anti-thyroid antibodies; Creutzfeldt-Jakob disease (CJD) is a prion disease. Both disorders can have a similar clinical presentation. Two women, 67 and 63 year-old, with subacute dementia, ataxia, myoclonus and positive antithyroid antibodies were given oral steroids. Whereas one progressively declined and had histopathologically proven CJD, the other made a complete recovery and was diagnosed with HE. Anti-thyroid antibodies can occur in CJD, but when present in a patient with subacute dementia, ataxia and myoclonus, a steroid trial always seems indicated.
authors.affiliation: Neurologisk Klinik, Afsnit 2094, Rigshospitalet, Blegdamsvej 9, 2100 København Ø, Denmark. daniel_kondziella@yahoo.com
authors.forename: Daniel
authors.initials: D
authors.lastname: Kondziella
authors.forename: Klaus
authors.initials: K
authors.lastname: Hansen
authors.forename: Teresa
authors.initials: T
authors.lastname: Gonzalez
authors.forename: Peter
authors.initials: P
authors.lastname: Gideon
authors.forename: Ingelise
authors.initials: I
authors.lastname: Christiansen
authors.forename: Finn
authors.initials: F
authors.lastname: Sellebjerg
mesh_terms: D000368:Aged; D000906:Antibodies / Q000032:analysis; D001259:Ataxia / Q000175:diagnosis*; D001927:Brain Diseases / Q000175:diagnosis* / Q000188:drug therapy; D054022:Cerebrum / Q000473:pathology; D007562:Creutzfeldt-Jakob Syndrome / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D003704:Dementia / Q000175:diagnosis*; D003937:Diagnosis, Differential; D004660:Encephalitis; D017809:Fatal Outcome; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D050031:Hashimoto Disease / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D008609:Mental Status Schedule; D008875:Middle Aged; D009207:Myoclonus / Q000175:diagnosis*; D011239:Prednisolone / Q000627:therapeutic use; D013961:Thyroid Gland / Q000276:immunology
chemical_list: D000906:Antibodies; D005938:Glucocorticoids; D011239:Prednisolone