title: Hybrid nanocrystals: University of Kentucky US20060280680A1.
abstract: This patent application claims an interesting and novel combination of passive accumulation of drug nanocrystals within diseased tissue, in combination with active uptake of the nanocrystals by diseased cells. The patent application further claims the hybrid nanocrystals combining imaging or stabilizing molecules as inclusions in the crystal matrix. There is a focus on cancer chemotherapy and imaging, but the initial claims are not disease specific. In this patent evaluation, the novelty and utility of this application is examined, while the state of the art in nanocrystal formulations and formulation is discussed.
authors.affiliation: University of Illinois, Department of Biopharmaceutical Sciences, Chicago, IL 60612-7231, USA.
authors.forename: Jamie E
authors.initials: JE
authors.lastname: Rayahin
authors.forename: Jason S
authors.initials: JS
authors.lastname: Buhrman
authors.forename: Richard A
authors.initials: RA
authors.lastname: Gemeinhart
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D016503:Drug Delivery Systems; D015195:Drug Design; D006801:Humans; D053758:Nanoparticles; D036103:Nanotechnology / Q000379:methods; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D010330:Patents as Topic
chemical_list: D000970:Antineoplastic Agents