title: Adherence to oral tyrosine kinase inhibitor therapies in chronic myeloid leukemia.
abstract: Ensuring adherence to therapy is a challenge in chronic diseases, particularly in cancers such as chronic myeloid leukemia (CML), where there has been increased availability and use of oral formulations. A conceptual model of adherence was developed based on findings from a comprehensive literature review, to inform strategies for improving adherence to oral CML therapies. A complex interplay of factors (including clinical, psychological and behavioural) influence adherence to such therapies. Healthcare professionals have a key role in promoting and facilitating adherence and future strategies should place greater emphasis on understanding patient-level experiences in order to create personalized solutions.
authors.affiliation: Patient Reported Outcomes, Adelphi Values, Cheshire, UK. adam.gater@mapivalues.com
authors.forename: Adam
authors.initials: A
authors.lastname: Gater
authors.forename: Louise
authors.initials: L
authors.lastname: Heron
authors.forename: Linda
authors.initials: L
authors.lastname: Abetz-Webb
authors.forename: John
authors.initials: J
authors.lastname: Coombs
authors.forename: Jeff
authors.initials: J
authors.lastname: Simmons
authors.forename: François
authors.initials: F
authors.lastname: Guilhot
authors.forename: Delphine
authors.initials: D
authors.lastname: Rea
mesh_terms: D000284:Administration, Oral; D000970:Antineoplastic Agents / Q000008:administration & dosage; D002986:Clinical Trials as Topic / Q000706:statistics & numerical data; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy* / Q000453:epidemiology; D008954:Models, Biological; D017060:Patient Satisfaction / Q000706:statistics & numerical data; D047428:Protein Kinase Inhibitors / Q000008:administration & dosage*; D016903:Drug Monitoring
chemical_list: D000970:Antineoplastic Agents; D047428:Protein Kinase Inhibitors