title: Two new cytotoxic candidaspongiolides from an indonesian sponge.
abstract: Marine sponges have been recognized as potentially rich sources of various bioactive molecules. In our continuing search for new secondary metabolites from Indonesian marine invertebrates, we collected a sponge, whose extract showed cytotoxicity against cultured cells at 0.1 μg/mL. Purification of the extract yielded two new macrolides 2 and 3 along with known candidaspongiolide (1). The structures for compounds 2 and 3 were elucidated by spectral analysis ((1)H, (13)C, COSY, HMQC, HMBC) and by comparison of their NMR data with those of 1. Compounds 2 and 3 exhibited a little more potent cytotoxicity (IC(50) 4.7 and 19 ng/mL) than that (IC(50) 37 ng/mL) of candidaspongiolide (1) against NBT-T2 cells.
authors.affiliation: Department of Chemistry, Biology, and Marine Science, University of the Ryukyus, Senbaru 1, Nishihara, Okinawa 903-0213, Japan.
authors.forename: Agus
authors.initials: A
authors.lastname: Trianto
authors.forename: Idam
authors.initials: I
authors.lastname: Hermawan
authors.forename: Toshimasa
authors.initials: T
authors.lastname: Suzuka
authors.forename: Junichi
authors.initials: J
authors.lastname: Tanaka