title: Spontaneous regression of pulmonary involvement after smoking reduction and removal of and radiation therapy for Langerhans cell histiocytosis of the sphenoid bone: which comes first, the chicken or the egg?
abstract: Isolated pulmonary Langerhans cell histiocytosis (LCH) in adults is known to regress spontaneously after smoking cessation alone, but little is known about whether this rationale could also apply in cases of multisystem pulmonary LCH. In particular, pediatric patients with multisystem LCH including involvement in "risk organs" such as lungs often benefit from systemic chemotherapy. Here, we present a 37-year-old man with spontaneous regression of pulmonary lesions in multisystem LCH, achieved solely by smoking reduction following local treatment of bone lesions.
authors.affiliation: Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine, Japan. tamakhi@hyo-med.ac.jp
authors.forename: Hiroya
authors.initials: H
authors.lastname: Tamaki
authors.forename: Shigekazu
authors.initials: S
authors.lastname: Fujita
authors.forename: Ruri
authors.initials: R
authors.lastname: Kato
authors.forename: Yoshitane
authors.initials: Y
authors.lastname: Tsukamoto
authors.forename: Seiichi
authors.initials: S
authors.lastname: Hirota
authors.forename: Norio
authors.initials: N
authors.lastname: Arita
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Ogawa
mesh_terms: D000328:Adult; D001847:Bone Diseases / Q000532:radiotherapy*; D006646:Histiocytosis, Langerhans-Cell / Q000628:therapy*; D006801:Humans; D008171:Lung Diseases / Q000628:therapy*; D008297:Male; D011878:Radiotherapy; D012075:Remission, Spontaneous; D016540:Smoking Cessation; D013100:Sphenoid Bone / Q000528:radiation effects*; D016896:Treatment Outcome