title: The preventive effects of apolipoprotein mimetic D-4F from vibration injury-experiment in rats.
abstract: Hand-arm vibration syndrome (HAVS) is a debilitating sequela of neurological and vascular injuries caused by prolonged occupational exposure to hand-transmitted vibration. Our previous study demonstrated that short-term exposure to vibration can induce vasoconstriction and endothelial cell damage in the ventral artery of the rat's tail. The present study investigated whether pretreatment with D-4F, an apolipoprotein A-1 mimetic with known anti-oxidant and vasodilatory properties, prevents vibration-induced vasoconstriction, endothelial cell injury, and protein nitration. Rats were injected intraperitoneally with 3 mg/kg D-4F at 1 h before vibration of the tails for 4 h/day at 60 Hz, 49 m/s(2) r.m.s. acceleration for either 1 or 3 days. Vibration-induced endothelial cell damage was examined by light microscopy and nitrotyrosine immunoreactivity (a marker for free radical production). One and 3-day vibration produced vasoconstriction and increased nitrotyrosine. Preemptive treatment with D-4F prevented these negative changes. These findings suggest that D-4F may be useful in the prevention of HAVS.
authors.forename: David J
authors.initials: DJ
authors.lastname: Rowe
authors.forename: Ji-Geng
authors.initials: JG
authors.lastname: Yan
authors.forename: Lin Ling
authors.initials: LL
authors.lastname: Zhang
authors.forename: Kirkwood A
authors.initials: KA
authors.lastname: Pritchard
authors.forename: Dennis S
authors.initials: DS
authors.lastname: Kao
authors.forename: Hani S
authors.initials: HS
authors.lastname: Matloub
authors.forename: Danny A
authors.initials: DA
authors.lastname: Riley