title: The effect of neoadjuvant chemoradiotherapy on airway colonization and postoperative respiratory complications in patients undergoing oesophagectomy for oesophageal cancer.
abstract: Respiratory complication is one of the important postoperative complications of oesophageal cancer. The aim of this study was to evaluate whether neoadjuvant chemotherapy before surgery is effective for postoperative respiratory complications. In this study, patients with oesophageal cancer were divided into two group: one with neoadjuvant therapy and the other without neoadjuvant therapy. Before surgery, they all underwent bronchoscopy and bronchoalveolar lavage. We evaluated respiratory complications and the effects of preoperative neoadjuvant therapy. Forty patients (M/F = 23/17 and mean age 61 years) were enrolled in this study. Twenty-two cases had cancer in the middle part and 18 in the lower part of the oesophagus. Significant correlation was observed between the number of positive micro-organism and difficulty in weaning and receiving neoadjuvant therapy. But no significant correlation was found between neoadjuvant therapy and respiratory complications.
authors.affiliation: Endoscopic and Minimally Invasive Surgery Research Center, Ghaem Hospital,  Mashhad University of Medical Sciences, Mashhad,  Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Bagheri
authors.forename: Mohammad Taghi
authors.initials: MT
authors.lastname: RajabiMashhadi
authors.forename: Kiyarash
authors.initials: K
authors.lastname: Ghazvini
authors.forename: Amir
authors.initials: A
authors.lastname: Asnaashari
authors.forename: Ali
authors.initials: A
authors.lastname: Zahediyan
authors.forename: Mehdi Abasi
authors.initials: MA
authors.lastname: Sahebi
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D018893:Bronchoalveolar Lavage; D001999:Bronchoscopy; D059186:Chemoradiotherapy, Adjuvant / Q000009:adverse effects* / Q000401:mortality; D002945:Cisplatin / Q000008:administration & dosage; D004938:Esophageal Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000401:mortality / Q000601:surgery / Q000628:therapy*; D016629:Esophagectomy / Q000009:adverse effects* / Q000401:mortality; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D017052:Hospital Mortality; D006801:Humans; D007492:Iran; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy / Q000009:adverse effects* / Q000401:mortality; D011859:Radiography; D011879:Radiotherapy Dosage; D012120:Respiration Disorders / Q000209:etiology* / Q000401:mortality / Q000628:therapy; D012141:Respiratory Tract Infections / Q000209:etiology* / Q000382:microbiology / Q000401:mortality / Q000628:therapy; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D015300:Ventilator Weaning
chemical_list: D002945:Cisplatin; D005472:Fluorouracil