title: A case of rosai-dorfman disease with highly elevated serum ferritin.
abstract: Sinus histiocytosis with massive lymphadenopathy, also known as Rosai-Dorfman disease is a rare disorder characterized by proliferation of distinctive histiocytes within lymph node sinuses and lymphatics, sometimes involving extranodal sites. However, clinical suspicion is difficult and there is also a lack of useful diagnostic markers for this disorder prior to histological confirmation. High elevation of serum ferritin is known to be a useful diagnostic marker for various hematologic diseases, including hemophagocytic lymphohistiocytosis and lymphoma. Here, we report a case of fever of unknown origin that presented along with highly elevated serum ferritin (5,780 ng/mL), and was finally diagnosed as Rosai-Dorfman disease by lymph node biopsy.
authors.affiliation: Department of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
authors.forename: Sung-Yoon
authors.initials: SY
authors.lastname: Rew
authors.forename: Hee-Chang
authors.initials: HC
authors.lastname: Jang
authors.forename: Kyung-Hwa
authors.initials: KH
authors.lastname: Park
authors.forename: Jae-Sook
authors.initials: JS
authors.lastname: Ahn
authors.forename: Ga-Eon
authors.initials: GE
authors.lastname: Kim
authors.forename: Yoo-Duk
authors.initials: YD
authors.lastname: Choi
authors.forename: Sook-In
authors.initials: SI
authors.lastname: Jung
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D005293:Ferritins / Q000097:blood*; D015618:Histiocytosis, Sinus / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008198:Lymph Nodes / Q000473:pathology; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed
chemical_list: D002097:C-Reactive Protein; D005293:Ferritins; D007770:L-Lactate Dehydrogenase