title: [Significance of biliary dysfunction in the pathogenesis of gallstone disease].
abstract: The paper shows the role of biliary dysfunction in the formation of biliary sludge. Found that among all motor dysfunction themost common is reduction of contractile function of the gallbladder (in 63.3% of cases), which is combined with 73.2% Oddi's sphincter hypertonus. T The combination of ursodeoxycholic acid (UDCA) with mebeverine has a better effect than monotherapy with UDCA, as increases the frequency of relief of biliary dyspepsia symptoms, normalizes the biliary tract functional status and 95% of cases leads to the elimination of biliary sludge.
authors.forename: I A
authors.initials: IA
authors.lastname: Il'chenko
authors.forename: O V
authors.initials: OV
authors.lastname: Deliukina
mesh_terms: D000328:Adult; D001646:Bile; D001657:Biliary Dyskinesia / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D002756:Cholagogues and Choleretics / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D042882:Gallstones / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D008297:Male; D010627:Phenethylamines / Q000008:administration & dosage / Q000627:therapeutic use*; D046628:Sphincter of Oddi Dysfunction / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D014580:Ursodeoxycholic Acid / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D002756:Cholagogues and Choleretics; D010627:Phenethylamines; D014580:Ursodeoxycholic Acid; C005096:mebeverine