title: The effect of chlorotrimethylsilane on bonding of nano hydroxyapatite with a chitosan-polyacrylamide matrix.
abstract: Stimuli sensitive biodegradable polymers have important applications in the fields of drug delivery and tissue engineering. In this study, biodegradable composite films of chitosan-polyacrylamide-nano hydroxyapatite (Cs-PAAm-nHA) with different concentrations of Chlorotrimethylsilane (CTMS) were fabricated and characterized using Fourier transform infrared (FTIR) spectroscopy. FTIR and XRD results suggested that CTMS functioned to couple nHA with the Cs-PAAm polymer matrix. The swelling study indicated that the formation of numerous CTMS based inter-chain bridges and pores facilitated water absorption and swelling. Hence, incorporation of CTMS into Cs-PAAm-nHA composites not only improved their stability but also controlled the degradation of the composites, which are important for drug delivery applications.
authors.affiliation: Department of Chemistry, Anna University, Chennai 600 025, India.
authors.forename: Aravind
authors.initials: A
authors.lastname: Bhat Kalambettu
authors.forename: Padmavathi
authors.initials: P
authors.lastname: Rajangam
authors.forename: Sangeetha
authors.initials: S
authors.lastname: Dharmalingam
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D048271:Chitosan / Q000737:chemistry*; D017886:Durapatite / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D049329:Nanostructures / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D014297:Trimethylsilyl Compounds / Q000737:chemistry*; D014961:X-Ray Diffraction; D000099166:Polyacrylamides
chemical_list: D000180:Acrylic Resins; D048271:Chitosan; D017886:Durapatite; D014297:Trimethylsilyl Compounds; D000099166:Polyacrylamides; C039293:trimethylchlorosilane