title: Using PDE inhibitors to harness the benefits of calorie restriction: lessons from resveratrol.
abstract: In conclusion, the discovery of the resveratrol-PDE link suggests that PDE4 inhibitors, possibly in combination with other PDE inhibitors, may be useful for mimicking CR and for treating aging-related diseases.
authors.affiliation: Laboratory of Obesity and Aging Research, Genetics andDevelopmental Biology Center, National Heart Lung and BloodInstitute, National Institutes of Health, Bethesda, MD 20892, USA. chungj@nhlbi.nih.gov
authors.forename: Jay H
authors.initials: JH
authors.lastname: Chung
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D031204:Caloric Restriction; D004734:Energy Metabolism / Q000187:drug effects*; D004789:Enzyme Activation; D020536:Enzyme Activators / Q000494:pharmacology*; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology*; D000077185:Resveratrol; D056564:Sirtuin 1 / Q000378:metabolism; D013267:Stilbenes / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; D020536:Enzyme Activators; D007004:Hypoglycemic Agents; D010726:Phosphodiesterase Inhibitors; D013267:Stilbenes; D056564:Sirtuin 1; D000077185:Resveratrol