title: [Contributions of immunogenic cell death to the efficacy of anticancer chemotherapy].
abstract: Immunogenic cell death, characterized by calreticulin exposure on the surface of the dying cell, release of the nuclear protein high mobility group box 1 (HMGB1), and release of ATP, enables stimulation of the immune system. We outlined the importance of this kind of cell death for the success of some anticancer chemotherapies. However, defects in the immunogenic cell death signalling pathway can lead to therapeutic failure, apparently because anticancer immune responses must contribute to the efficacy of chemotherapeutic regimens. These defects can be related to the therapy, the tumour cell, the host or the tumour-host interface. It is necessary to characterize these defects to restore and improve the efficacy of anticancer chemotherapies.
authors.affiliation: Institut Gustave Roussy, Paris, France.
authors.forename: G
authors.initials: G
authors.lastname: Kroemer
authors.forename: Sandy
authors.initials: S
authors.lastname: Adjemian
authors.forename: Mickaël
authors.initials: M
authors.lastname: Michaud
authors.forename: Isabelle
authors.initials: I
authors.lastname: Martins
authors.forename: Oliver
authors.initials: O
authors.lastname: Kepp
authors.forename: Abdul Qader
authors.initials: AQ
authors.lastname: Sukkurwala
authors.forename: Laurie
authors.initials: L
authors.lastname: Menger
authors.forename: Erika
authors.initials: E
authors.lastname: Vacchelli
authors.forename: Yuting
authors.initials: Y
authors.lastname: Ma
authors.forename: Laurence
authors.initials: L
authors.lastname: Zitvogel
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D016923:Cell Death / Q000276:immunology*; D019008:Drug Resistance, Neoplasm / Q000276:immunology*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000276:immunology*
chemical_list: D000970:Antineoplastic Agents