title: [Chorea, lupus and antiphospholipid antibodies].
abstract: Chorea may occur in patients with SLE with a frequency estimated at 1 to 3% in adults and up to 9% in paediatric lupus. Chorea is frequently a presenting feature, and is strongly related to the presence of antiphospholipid antibodies. A treatment with antiplatelet agents and hydroxychloroquine is generally sufficient. During follow-up, the patients with chorea have a significant higher risk to develop thrombotic events (mainly arterial). They also have an excess risk of obstetric morbidity and valvular disease. The prescription of antiplatelet agents and adequate management, especially during pregnancy, can probably reduce this risk.
authors.affiliation: Service de neurologie, hôpital Lariboisière, université Paris-7, AP-HP, 75475 Paris cedex 10, France.
authors.forename: P
authors.initials: P
authors.lastname: Reiner
authors.forename: J-C
authors.initials: JC
authors.lastname: Piette
authors.forename: G
authors.initials: G
authors.lastname: Leroux
authors.forename: M
authors.initials: M
authors.lastname: Vidailhet
authors.forename: N
authors.initials: N
authors.lastname: Costedoat-Chalumeau
mesh_terms: D000328:Adult; D017152:Antibodies, Antiphospholipid / Q000097:blood*; D018501:Antirheumatic Agents / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D002648:Child; D002819:Chorea / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology* / Q000276:immunology; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D005602:France / Q000453:epidemiology; D006801:Humans; D006886:Hydroxychloroquine / Q000627:therapeutic use*; D007155:Immunologic Factors / Q000097:blood*; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D017152:Antibodies, Antiphospholipid; D018501:Antirheumatic Agents; D015415:Biomarkers; D007155:Immunologic Factors; D010975:Platelet Aggregation Inhibitors; D006886:Hydroxychloroquine