title: Activation of aerobic metabolism by Amaranth oil improves heart rate variability both in athletes and patients with type 2 diabetes mellitus.
abstract: The aim of present research was to study the effects of Amaranth oil (AmO) supplementation on aerobic metabolism and heart rate variability (HRV) in type 2 diabetes mellitus patients and in athletes. Several parameters of aerobic metabolism and HRV were assessed. Supplementation with AmO caused mild pro-oxidant activity resulting in improved uptake of oxidative destruction products and modulation of catalase and SOD activity with subsequent development of an antioxidant effect. These findings were very distinct in athletes but less pronounced in diabetics. Redistribution of haemoglobin ligands in athletes indicates involvement of haemoproteins in free radical reactions during AmO supplementation. Improvement in HRV by daily consumption of AmO as observed in both study groups suggested increased production of endogenous oxygen and enhancement of the cardio-respiratory function. The advantage of activation of aerobic metabolism in OS-related disorders resulting in improved self-organization of the living system and hormetic reaction mechanisms are discussed.
authors.affiliation: Danylo Halytsky Lviv National Medical University, Ukraine. yelisol@gmail.com
authors.forename: Olha
authors.initials: O
authors.lastname: Yelisyeyeva
authors.forename: Khrystyna
authors.initials: K
authors.lastname: Semen
authors.forename: Neven
authors.initials: N
authors.lastname: Zarkovic
authors.forename: Danylo
authors.initials: D
authors.lastname: Kaminskyy
authors.forename: Olexander
authors.initials: O
authors.lastname: Lutsyk
authors.forename: Volodymyr
authors.initials: V
authors.lastname: Rybalchenko
mesh_terms: D000332:Aerobiosis / Q000187:drug effects; D027721:Amaranthus / Q000737:chemistry*; D056352:Athletes; D003924:Diabetes Mellitus, Type 2 / Q000178:diet therapy / Q000378:metabolism* / Q000503:physiopathology*; D019587:Dietary Supplements; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010938:Plant Oils / Q000494:pharmacology* / Q000627:therapeutic use; D017382:Reactive Oxygen Species / Q000378:metabolism; D012639:Seeds / Q000737:chemistry; D055815:Young Adult
chemical_list: D010938:Plant Oils; D017382:Reactive Oxygen Species