title: A short-term toxicity study of Aspergillus carbonarius carotenoid.
abstract: In a pharmacokinetic study, high-performance liquid chromatography analysis of blood samples of Wistar female rats fed with partially saturated canthaxanthin (PSC) of Aspergillus carbonarius showed the presence of the carotenoid in the plasma within 6 hours of feeding. In another study for safety assessment of PSC fed to rats over a period of 28 days at 0.05%, 0.10%, and 0.25%, the rats showed no changes in food intake. There were no significant differences observed in body weight, hematological parameters, or serum clinical enzymes compared to the control group not fed with PSC. Deposition of PSC in the eyes of the rats was also not observed. The results showed that PSC-fed rats were not adversely affected as far as toxicological studies were concerned.
authors.affiliation: Department of Food Microbiology, Central Food Technological Research Institute-CFTRI, Council of Scientific and Industrial Research-CSIR, Mysore 570020, India.
authors.forename: Anbarasu
authors.initials: A
authors.lastname: Kumar
authors.forename: Akshatha Hosahalli
authors.initials: AH
authors.lastname: Srikanta
authors.forename: Muthukumar Serva
authors.initials: MS
authors.lastname: Peddha
authors.forename: Umesh-Kumar
authors.initials: UK
authors.lastname: Sukumaran
authors.forename: Vijayalakshmi
authors.initials: V
authors.lastname: Govindaswamy
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000493:pharmacokinetics / Q000633:toxicity*; D019540:Area Under Curve; D001230:Aspergillus; D016644:Canthaxanthin / Q000097:blood / Q000493:pharmacokinetics / Q000633:toxicity*; D004396:Coloring Agents / Q000633:toxicity*; D005260:Female; D005503:Food Additives / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D059551:Toxicity Tests, Subacute
chemical_list: D000975:Antioxidants; D004396:Coloring Agents; D005503:Food Additives; D016644:Canthaxanthin