title: From HLA association to function.
abstract: A new study refines the association signals for rheumatoid arthritis susceptibility in the major histocompatibility complex (MHC) region to five amino-acid positions encoded in three HLA genes, all within peptide-binding grooves. By adapting statistical methods from genome-wide association studies (GWAS) and using imputation from a large reference panel, they demonstrate the potential for this approach to identify functional variants in associated regions.
authors.affiliation: Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK. barrett@sanger.ac.uk
authors.forename: Jeffrey C
authors.initials: JC
authors.lastname: Barrett
mesh_terms: D019943:Amino Acid Substitution / Q000235:genetics*; D001172:Arthritis, Rheumatoid / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D059868:HLA-DP beta-Chains / Q000235:genetics*; D059811:HLA-DRB1 Chains / Q000235:genetics*; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics*; D008958:Models, Molecular
chemical_list: D015235:HLA-B Antigens; D059868:HLA-DP beta-Chains; C071170:HLA-DPB1 antigen; D059811:HLA-DRB1 Chains