title: Carriage of an ACME II variant may have contributed to methicillin-resistant Staphylococcus aureus sequence type 239-like strain replacement in Liverpool Hospital, Sydney, Australia.
abstract: Approximately 39% of methicillin-resistant Staphylococcus aureus (MRSA) sequence type 239 (ST239)-like bloodstream isolates from Liverpool Hospital (obtained between 1997 and 2008) carry an arginine catabolic mobile element (ACME). Whole-genome sequencing revealed that an ACME II variant is located between orfX and SCCmec III, and based on pulsed-field gel electrophoresis patterns and temporal relationships of all ST239-like isolates (n = 360), ACME carriage may have contributed to subpulsotype strain replacement.
authors.affiliation: Antibiotic Resistance & Mobile Elements Group, School of Medicine, University of Western Sydney, NSW, Australia.
authors.forename: B A
authors.initials: BA
authors.lastname: Espedido
authors.forename: J A
authors.initials: JA
authors.lastname: Steen
authors.forename: T
authors.initials: T
authors.lastname: Barbagiannakos
authors.forename: J
authors.initials: J
authors.lastname: Mercer
authors.forename: D L
authors.initials: DL
authors.lastname: Paterson
authors.forename: S M
authors.initials: SM
authors.lastname: Grimmond
authors.forename: M A
authors.initials: MA
authors.lastname: Cooper
authors.forename: I B
authors.initials: IB
authors.lastname: Gosbell
authors.forename: S J
authors.initials: SJ
authors.lastname: van Hal
authors.forename: S O
authors.initials: SO
authors.lastname: Jensen
mesh_terms: D001315:Australia; D001426:Bacterial Proteins / Q000235:genetics*; D016521:Electrophoresis, Gel, Pulsed-Field; D006761:Hospitals; D055624:Methicillin-Resistant Staphylococcus aureus / Q000235:genetics*; D016133:Polymerase Chain Reaction
chemical_list: D001426:Bacterial Proteins