title: Putting genome analysis to good use: lessons from C-reactive protein and cardiovascular disease.
abstract: New methods of studying the human genome offer novel ways to examine the relationship between biomarkers and common, chronic human diseases. As an example, we will review a large genomics study (Elliott et al, JAMA 2009; 302:37-48) that concluded that C-reactive protein (CRP) is likely not a cause of coronary heart disease, although it is a marker for it.
authors.affiliation: Department of Genetics, Kaiser Permanente Oakland Medical Center, Oakland, CA 94611-5693, USA. leslie.c.manace@kp.org
authors.forename: Leslie Cole
authors.initials: LC
authors.lastname: Manace
authors.forename: Mark Warren
authors.initials: MW
authors.lastname: Babyatsky
mesh_terms: D015415:Biomarkers; D002097:C-Reactive Protein / Q000032:analysis*; D002318:Cardiovascular Diseases / Q000235:genetics* / Q000473:pathology; D015894:Genome, Human; D055106:Genome-Wide Association Study; D006801:Humans; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein