title: Anti-proliferative effects of the novel ceramide analog (S)-2-(benzylideneamino)-3-hydroxy-N-tetrade-cylpropanamide in chemoresistant cancer.
abstract: The ceramide-sphingosine-1-phosphate rheostat is a promising therapeutic target. Here, the novel ceramide analog (S)-2-(benzylideneamino)-3-hydroxy-N-tetrade-cylpropanamide is shown to block proliferation and enhance the efficacy of the clinical chemotherapeutics, etoposide and doxorubicin. These results demonstrate the therapeutic potential of this compound in treating both endocrine resistant and chemoresistant breast cancer.
authors.affiliation: Department of Pharmacology, Tulane University School of Medicine, 1430 Tulane Ave. SL-83, New Orleans, LA 70112, USA.
authors.forename: James W
authors.initials: JW
authors.lastname: Antoon
authors.forename: Barbara S
authors.initials: BS
authors.lastname: Beckman
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D001943:Breast Neoplasms / Q000188:drug therapy; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002518:Ceramides / Q000138:chemical synthesis* / Q000494:pharmacology; D004317:Doxorubicin / Q000494:pharmacology; D019008:Drug Resistance, Neoplasm; D004357:Drug Synergism; D005047:Etoposide / Q000494:pharmacology; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000096:biosynthesis; D008246:Lysophospholipids / Q000378:metabolism; D013110:Sphingosine / Q000031:analogs & derivatives / Q000378:metabolism; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: C573361:(S)-2-(benzylideneamino)-3-hydroxy-N-tetrade-cylpropanamide; D000970:Antineoplastic Agents; D002518:Ceramides; D019394:Ki-67 Antigen; D008246:Lysophospholipids; C060506:sphingosine 1-phosphate; D005047:Etoposide; D004317:Doxorubicin; D013110:Sphingosine