title: Transforming growth factor-beta1 (509 C/T, 915 G/C, 869 T/C) polymorphisms are not related to obesity in Turkish children.
abstract: Increasing expression of transforming growth factor-beta 1 (TGF-beta1) from fatty tissue affects the serum level and hence may stimulate expression of the other cytokines. The studies concerning the relation between TGF-beta1 polymorphisms and obesity have been performed in adults, and diverse results have been reported. In this study, we aimed to investigate the association of TGF-beta1 509 C/T, 915 G/C, 869 T/C polymorphisms in childhood obesity and related pathologies. Two hundred and seventy-one children and adolescents were included in the study. One hundred and twenty-one of these cases were in the Obese Group and 150 were in the Control Group. In the Obesity Group, we searched the carbohydrate and lipid metabolism disorders such as insulin resistance, dyslipidemia and hepatosteatosis. The results of this study revealed the lack of an association between TGF-beta1 509 C/T, 915 G/C and 869 T/C polymorphisms and obesity. There were no relations between the polymorphism genotypes and obesity-related metabolic disturbances.
authors.affiliation: Department of Pediatrics, Baskent University Faculty of Medicine, Ankara, Turkey.
authors.forename: Ali Riza
authors.initials: AR
authors.lastname: Kanra
authors.forename: Sibel
authors.initials: S
authors.lastname: Tulgar-Kinik
authors.forename: Hasibe
authors.initials: H
authors.lastname: Verdi
authors.forename: F Belgin
authors.initials: FB
authors.lastname: Ataç
authors.forename: Ayse Canan
authors.initials: AC
authors.lastname: Yazici
authors.forename: Namik
authors.initials: N
authors.lastname: Ozbek
mesh_terms: D000293:Adolescent; D002648:Child; D050171:Dyslipidemias / Q000150:complications; D005234:Fatty Liver / Q000150:complications; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D009765:Obesity / Q000150:complications / Q000235:genetics* / Q000378:metabolism; D011110:Polymorphism, Genetic; D053773:Transforming Growth Factor beta1 / Q000235:genetics*; D014421:Turkey
chemical_list: D053773:Transforming Growth Factor beta1