title: Outcomes of a Latino community-based intervention for the prevention of diabetes: the Lawrence Latino Diabetes Prevention Project.
abstract: OBJECTIVE
  We tested the effectiveness of a community-based, literacy-sensitive, and culturally tailored lifestyle intervention on weight loss and diabetes risk reduction among low-income, Spanish-speaking Latinos at increased diabetes risk.
  
  
  METHODS
  Three hundred twelve participants from Lawrence, Massachusetts, were randomly assigned to lifestyle intervention care (IC) or usual care (UC) between 2004 and 2007. The intervention was implemented by trained Spanish-speaking individuals from the community. Each participant was followed for 1 year.
  
  
  RESULTS
  The participants' mean age was 52 years; 59% had less than a high school education. The 1-year retention rate was 94%. Compared with the UC group, the IC group had a modest but significant weight reduction (-2.5 vs 0.63 lb; P = .04) and a clinically meaningful reduction in hemoglobin A1c (-0.10% vs -0.04%; P = .009). Likewise, insulin resistance improved significantly in the IC compared with the UC group. The IC group also had greater reductions in percentage of calories from total and saturated fat.
  
  
  CONCLUSIONS
  We developed an inexpensive, culturally sensitive diabetes prevention program that resulted in weight loss, improved HbA1c, and improved insulin resistance in a high-risk Latino population.
authors.affiliation: Division of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA. Ira.Ockene@umassmed.edu
authors.forename: Ira S
authors.initials: IS
authors.lastname: Ockene
authors.forename: Trinidad L
authors.initials: TL
authors.lastname: Tellez
authors.forename: Milagros C
authors.initials: MC
authors.lastname: Rosal
authors.forename: George W
authors.initials: GW
authors.lastname: Reed
authors.forename: John
authors.initials: J
authors.lastname: Mordes
authors.forename: Philip A
authors.initials: PA
authors.lastname: Merriam
authors.forename: Barbara C
authors.initials: BC
authors.lastname: Olendzki
authors.forename: Garry
authors.initials: G
authors.lastname: Handelman
authors.forename: Robert
authors.initials: R
authors.lastname: Nicolosi
authors.forename: Yunsheng
authors.initials: Y
authors.lastname: Ma
mesh_terms: D000328:Adult; D000368:Aged; D003153:Community Health Services / Q000458:organization & administration*; D054521:Cultural Competency; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000517:prevention & control*; D004032:Diet; D015444:Exercise; D006442:Glycated Hemoglobin; D015438:Health Behavior; D006293:Health Promotion / Q000458:organization & administration*; D006630:Hispanic or Latino; D006801:Humans; D007333:Insulin Resistance; D008019:Life Style; D008404:Massachusetts; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D011203:Poverty; D012959:Socioeconomic Factors; D015431:Weight Loss
chemical_list: D006442:Glycated Hemoglobin