title: Expression of "a disintegrin and metalloproteinase-33" (ADAM-33) protein in laryngeal squamous cell carcinoma.
abstract: OBJECTIVE
  A disintegrin and metalloproteinase domain containing protein 33 (also known as ADAM-33) is a member of a matrix metalloproteinase family which mediates extracellular matrix remodelling and changes in cellular adhesion. This study aimed to evaluate expression of this protein in laryngeal squamous cell carcinoma, and to determine its correlation with patients' clinicopathological characteristics.
  
  
  METHODS
  Forty paraffin blocks of laryngeal carcinoma underwent immunohistochemical staining to detect "a disintegrin and metalloproteinase-33" expression. Case records were reviewed to determine patient characteristics.
  
  
  RESULTS
  All epithelial, vascular and stromal staining scores were significantly increased in tumour tissue compared with controls (p < 0.001). However, patients' clinical characteristics at the time of diagnosis, and their disease extent, did not correlate significantly with the immunohistochemical staining scores.
  
  
  CONCLUSIONS
  This study suggests that increased expression of "a disintegrin and metalloproteinase-33" may play a role in the pathogenesis of laryngeal carcinoma.
authors.affiliation: Department of Otolaryngology, Faculty of Medicine, Başkent University, Ankara, Turkey. ozgultopal75@yahoo.com
authors.forename: O
authors.initials: O
authors.lastname: Topal
authors.forename: H
authors.initials: H
authors.lastname: Erinanc
authors.forename: C
authors.initials: C
authors.lastname: Ozer
authors.forename: E T
authors.initials: ET
authors.lastname: Canpolat
authors.forename: S B
authors.initials: SB
authors.lastname: Celik
authors.forename: S S
authors.initials: SS
authors.lastname: Erbek
mesh_terms: D051722:ADAM Proteins / Q000378:metabolism* / Q000502:physiology; D000328:Adult; D000368:Aged; D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D002448:Cell Adhesion / Q000502:physiology; D005109:Extracellular Matrix / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007822:Laryngeal Neoplasms / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011817:Rabbits; D012189:Retrospective Studies; D013194:Staining and Labeling / Q000379:methods; D046888:Tissue Array Analysis / Q000379:methods
chemical_list: D014408:Biomarkers, Tumor; D051722:ADAM Proteins; C450441:ADAM33 protein, human