title: New dopamine agonist pramipexole improves parkinsonism and depression in Parkinson's disease.
abstract: Previous studies have shown that pramipexole might have the potential to improve depressive symptoms in patients with Parkinson's disease. To provide more evidence, in five Japanese patients at Hoehn & Yahr stage 1-3 we evaluated the Unified Parkinson's Disease Rating Scale (UPDRS), Hamilton Depression Rating Scale (HAMD) and Montgomery Asberg Depression Rating Scale (MADRS) at our hospital. After the pramipexole treatment, each total score of UPDRS, HAMD and MADRS significantly decreased compared with that before the treatment. Our data indicate that pramipexole improves depressive symptoms in patients with Parkinson's disease.
authors.affiliation: Faculty of Health and Welfare, Prefectural University of Hiroshima, 1-1, Gakuen-machi, Mihara, Hiroshima 723-0053, Japan. hartoshi@pu-hiroshima.ac.jp
authors.forename: Toshihide
authors.initials: T
authors.lastname: Harada
authors.forename: Fumiko
authors.initials: F
authors.lastname: Ishizaki
authors.forename: Nobuko
authors.initials: N
authors.lastname: Horie
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Nitta
authors.forename: Tohru
authors.initials: T
authors.lastname: Yamada
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Sasaki
authors.forename: Tomoomi
authors.initials: T
authors.lastname: Nagakane
authors.forename: Yoshiteru
authors.initials: Y
authors.lastname: Yasumatsu
authors.forename: Kohsaku
authors.initials: K
authors.lastname: Nitta
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Katsuoka
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D052160:Benzothiazoles / Q000494:pharmacology* / Q000627:therapeutic use; D003863:Depression / Q000150:complications / Q000188:drug therapy*; D018491:Dopamine Agonists / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications / Q000188:drug therapy*; D000077487:Pramipexole
chemical_list: D052160:Benzothiazoles; D018491:Dopamine Agonists; D000077487:Pramipexole