title: Common variants at 11q12, 10q26 and 3p11.2 are associated with prostate cancer susceptibility in Japanese.
abstract: We have previously reported multiple loci associated with prostate cancer susceptibility in a Japanese population using a genome-wide association study (GWAS). To identify additional prostate cancer susceptibility loci, we genotyped nine SNPs that were nominally associated with prostate cancer (P < 1 × 10(-4)) in our previous GWAS in three independent studies of prostate cancer in Japanese men (2,557 individuals with prostate cancer (cases) and 3,003 controls). In a meta-analysis of our previous GWAS and the replication studies, which included a total of 7,141 prostate cancer cases and 11,804 controls from a single ancestry group, three new loci reached genome-wide significance on chromosomes 11q12 (rs1938781; P = 1.10 × 10(-10); FAM111A-FAM111B), 10q26 (rs2252004; P = 1.98 × 10(-8)) and 3p11.2 (rs2055109; P = 3.94 × 10(-8)). We also found suggestive evidence of association at a previously reported prostate cancer susceptibility locus at 2p11 (rs2028898; P = 1.08 × 10(-7)). The identification of three new susceptibility loci should provide additional insight into the pathogenesis of prostate cancer and emphasizes the importance of conducting GWAS in diverse populations.
authors.affiliation: Laboratory for Biomarker Development, Center for Genomic Medicine, RIKEN, Tokyo, Japan.
authors.forename: Shusuke
authors.initials: S
authors.lastname: Akamatsu
authors.forename: Ryo
authors.initials: R
authors.lastname: Takata
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Haiman
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takahashi
authors.forename: Takahiro
authors.initials: T
authors.lastname: Inoue
authors.forename: Michiaki
authors.initials: M
authors.lastname: Kubo
authors.forename: Mutsuo
authors.initials: M
authors.lastname: Furihata
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Kamatani
authors.forename: Johji
authors.initials: J
authors.lastname: Inazawa
authors.forename: Gary K
authors.initials: GK
authors.lastname: Chen
authors.forename: Loïc
authors.initials: L
authors.lastname: Le Marchand
authors.forename: Laurence N
authors.initials: LN
authors.lastname: Kolonel
authors.forename: Takahiko
authors.initials: T
authors.lastname: Katoh
authors.forename: Yuko
authors.initials: Y
authors.lastname: Yamano
authors.forename: Minoru
authors.initials: M
authors.lastname: Yamakado
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Takahashi
authors.forename: Hiroki
authors.initials: H
authors.lastname: Yamada
authors.forename: Shin
authors.initials: S
authors.lastname: Egawa
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Fujioka
authors.forename: Brian E
authors.initials: BE
authors.lastname: Henderson
authors.forename: Tomonori
authors.initials: T
authors.lastname: Habuchi
authors.forename: Osamu
authors.initials: O
authors.lastname: Ogawa
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Hidewaki
authors.initials: H
authors.lastname: Nakagawa
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001483:Base Sequence; D002460:Cell Line; D002879:Chromosomes, Human, Pair 10 / Q000235:genetics*; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D007564:Japan; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011471:Prostatic Neoplasms / Q000235:genetics*; D034622:RNA Interference; D034741:RNA, Small Interfering; D017422:Sequence Analysis, DNA
chemical_list: D034741:RNA, Small Interfering