title: Effects of dietary resveratrol on the sleep-wake cycle in the non-human primate gray mouse lemur (Microcebus murinus).
abstract: Converging evidence shows that the non-human primate gray mouse lemur (Microcebus murinus) is ideal for the study of the aging process and for testing the effects of new therapies and dietary interventions on age-associated pathologies. One such dietary supplement is resveratrol (RSV), a dietary polyphenolic compound with several positive effects on metabolic functions and longevity. However, little is known about the effect of RSV on the lemur sleep-wake cycle, which reflects mammalian brain function and health. In the present study, the authors investigated this effect by comparing sleep-wake cycles in adult lemurs based on electroencephalographic (EEG) rhythms. The effect of short-term RSV supplementation on the sleep-wake cycle of mouse lemurs was evaluated in entrained conditions (long-day photoperiods, light:dark 14:10). After 3 wks of RSV supplementation, the animals exhibited a significantly increased proportion of active-wake time, occurring mainly during the resting phase of the sleep-wake cycle (+163%). The increase in active-wake time with RSV supplementation was accompanied by a significant reduction of both paradoxical sleep (-95%) and slow-wave sleep (-38%). These changes mainly occurred during the resting phase of the sleep-wake cycle (RSV supplementation induced negligible changes in active-wake time during the active phase of the sleep-wake cycle). The present data suggest that RSV may be a potent regulator of sleep-wake rhythms and could be of major interest in the study of sleep perturbations associated with aging and neuropathology.
authors.affiliation: UMR CNRS-MNHN 7179, Brunoy, France.
authors.forename: F
authors.initials: F
authors.lastname: Pifferi
authors.forename: A
authors.initials: A
authors.lastname: Rahman
authors.forename: S
authors.initials: S
authors.lastname: Languille
authors.forename: A
authors.initials: A
authors.lastname: Auffret
authors.forename: C
authors.initials: C
authors.lastname: Babiloni
authors.forename: O
authors.initials: O
authors.lastname: Blin
authors.forename: Y
authors.initials: Y
authors.lastname: Lamberty
authors.forename: J C
authors.initials: JC
authors.lastname: Richardson
authors.forename: F
authors.initials: F
authors.lastname: Aujard
mesh_terms: D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D016565:Cheirogaleidae / Q000502:physiology*; D002940:Circadian Rhythm / Q000187:drug effects* / Q000502:physiology; D019587:Dietary Supplements; D004569:Electroencephalography; D008297:Male; D017440:Photoperiod; D000077185:Resveratrol; D012890:Sleep / Q000187:drug effects* / Q000502:physiology; D012894:Sleep Stages / Q000187:drug effects / Q000502:physiology; D013267:Stilbenes / Q000008:administration & dosage*
chemical_list: D013267:Stilbenes; D000077185:Resveratrol