title: [Prenatal stressed female rats develop stable anxious and depressive state in experimental model of post-traumatic stress disorder].
abstract: The effects of immobilization stress from 15th to 19th days of gestation on pathological state development in the model of post-traumatic stress disorder in adult female offspring were studied. The results showed that prenatally stressed female rats as well as control rats demonstrated long-term high anxiety and hypersensitive glucocorticoid feedback in the stress-restress model. Enhanced depressive-like behaviour was found only in prenatally stressed females. The findings were discussed in the light of HPA axis alteration and risk factors for development of post-traumatic stress disorder.
authors.forename: N E
authors.initials: NE
authors.lastname: Ordian
authors.forename: S G
authors.initials: SG
authors.lastname: Pivina
authors.forename: Iu O
authors.initials: IuO
authors.lastname: Fedotova
authors.forename: V V
authors.initials: VV
authors.lastname: Rakitskaia
mesh_terms: D000818:Animals; D001007:Anxiety / Q000503:physiopathology; D003345:Corticosterone / Q000097:blood; D003863:Depression / Q000503:physiopathology*; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D007103:Immobilization; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000503:physiopathology*; D051381:Rats; D017208:Rats, Wistar; D013313:Stress Disorders, Post-Traumatic / Q000503:physiopathology; D013312:Stress, Physiological
chemical_list: D003345:Corticosterone; D006854:Hydrocortisone