title: Elevated serum cholesterol levels in women with premenstrual dysphoric disorder.
abstract: OBJECTIVE
  To study the association of premenstrual serum total cholesterol level (TC) with premenstrual dysphoric disorder (PMDD).
  
  
  METHODS
  The premenstrual serum cholesterol levels of 34 patients with PMDD and 20 normal controls were measured, and the rates ofhypercholesterolemia in the 2 groups were compared.
  
  
  RESULTS
  The mean of the premenstrual cholesterol level of the study group was 180.82 +/- 34.47 mg/dL, while that of the control group was 162.45 +/- 21.29 mg/dL (t = 2.152, df = 52, p = 0.036). The prevalence of premenstrual hypercholesterolemia (serum total cholesterol > 200 mg/dL) was 23.53% (8/34) in the PMDD group and zero in the normal control group (chi-square = 5.524, df = 1, p = 0.019).
  
  
  CONCLUSIONS
  The results showed elevated premenstrual serum cholesterol in PMDD and implied a new direction of research to further explore the etiology of PMDD. It is suggested that the pathophysiology of premenstrual dysphoric disorder may be similar to that of anxiety disorders.
authors.affiliation: Chang Gung Memorial Hospital at Linkou and Chang Gung University, Taiwan.
authors.forename: Mei-Chun
authors.initials: MC
authors.lastname: Hsiao
authors.forename: Chia-Yih
authors.initials: CY
authors.lastname: Liu
authors.forename: Shi-Chieh
authors.initials: SC
authors.lastname: Hsu
authors.forename: Cheng-Cheng
authors.initials: CC
authors.lastname: Hsiao
authors.forename: Yi-Hsiung
authors.initials: YH
authors.lastname: Lin
authors.forename: T'sang-T'ang
authors.initials: TT
authors.lastname: Hsieh
mesh_terms: D000328:Adult; D002784:Cholesterol / Q000097:blood; D015897:Comorbidity; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000453:epidemiology*; D008403:Mass Screening; D011293:Premenstrual Syndrome / Q000097:blood / Q000453:epidemiology*; D013624:Taiwan
chemical_list: D002784:Cholesterol