title: Urinary tract infections caused by staphylococcus aureus DNA in comparison to the candida albicans DNA.
abstract: BACKGROUND
  Bacterial DNA released upon bacterial autolysis or killed by antibiotics, hence, many inflammatogenic reactions will be established leading to serious tissue damage.
  
  
  OBJECTIVE
  the present work aimed to elucidate the histopathological changes caused by prokaryotic (bacterial) DNA and eukaryotic (candidal) DNA.
  
  
  METHODS
  twenty one Staphylococcus aureus and 36 Candida albicans isolates were isolated from UTI patients. Viable cells and DNA of the highest antibiotic sensitive isolates were injected, intraurethraly, in mice. Results were evaluated via histopathological examination.
  
  
  RESULTS
  Mildest reactions were obtained from mice challenged with viable C. albicans compared with those challenged with viable S. aureus. Dose-dependent histological changes were observed for both eukaryotic and prokaryotic DNA. However, the eukaryotic C. albicans DNA developed less intense histological changes than S. aureus DNA.
  
  
  CONCLUSIONS
  microbial DNA has the ability to cause damage in murine renal system. Nevertheless, bacterial DNA caused more intense damage than candidal DNA.
authors.affiliation: Department of Biology, College of Science, University of Baghdad, Baghdad, Iraq.
authors.forename: Harith Jabbar Fahad
authors.initials: HJ
authors.lastname: Al-Mathkhury
authors.forename: Saba Nazeih
authors.initials: SN
authors.lastname: Abdul-Ghaffar