title: NPY suppressed development of experimental autoimmune encephalomyelitis in Dark Agouti rats by disrupting costimulatory molecule interactions.
abstract: Neuropeptide Y (NPY) suppressed clinical experimental autoimmune encephalomyelitis (EAE) and reduced numbers of CD28+, CD11b+ and CD80+ cells among spinal cord infiltrating cells at the peak of disease in Dark Agouti rat strain. Suppression of EAE was accompanied by the reduced expression of costimulatory CD80 and CD86 molecules on ED1+ macrophages and OX62+ dendritic cells in draining lymph nodes during the inductive phase of EAE. An inhibitor of dipeptidyl peptidase 4, an enzyme which terminates the action of NPY on Y1 receptor subtype, did not sustain the suppressive effect of NPY on the EAE development, suggesting involvement of Y2 and Y5 receptors.
authors.affiliation: Institute of Virology, Vaccines and Sera, "Torlak", Immunology Research Center "Branislav Janković", Vojvode Stepe 458, 11152 Belgrade, Serbia. miradim@sezampro.rs
authors.forename: Mirjana
authors.initials: M
authors.lastname: Dimitrijević
authors.forename: Katarina
authors.initials: K
authors.lastname: Mitić
authors.forename: Nataša
authors.initials: N
authors.lastname: Kuštrimović
authors.forename: Vesna
authors.initials: V
authors.lastname: Vujić
authors.forename: Stanislava
authors.initials: S
authors.lastname: Stanojević
mesh_terms: D000818:Animals; D018122:B7-1 Antigen / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000378:metabolism; D039481:CD11b Antigen / Q000096:biosynthesis / Q000378:metabolism; D018106:CD28 Antigens / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000378:metabolism; D002452:Cell Count; D002465:Cell Movement / Q000276:immunology; D061025:Costimulatory and Inhibitory T-Cell Receptors / Q000037:antagonists & inhibitors* / Q000502:physiology; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology* / Q000473:pathology / Q000517:prevention & control*; D006801:Humans; D018836:Inflammation Mediators / Q000037:antagonists & inhibitors / Q000502:physiology; D008297:Male; D009478:Neuropeptide Y / Q000502:physiology*; D061251:Primary Cell Culture; D025941:Protein Interaction Mapping; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000276:immunology / Q000378:metabolism / Q000473:pathology
chemical_list: D018122:B7-1 Antigen; D039481:CD11b Antigen; D018106:CD28 Antigens; D061025:Costimulatory and Inhibitory T-Cell Receptors; D018836:Inflammation Mediators; D009478:Neuropeptide Y