title: Two new saponins from Thalictrum fortunei.
abstract: Two new cycloartane glycosides were isolated from the aerial parts of Thalictrum fortunei (Ranunculaceae). The chemical structures of these compounds were elucidated as 3-O-β-D-glucopyranosyl (1 → 4)-β-d-fucopyranosyl-(22S,24Z)-cycloart-24-en-3β,22,26,30-tetraol 26-O-β-D-glucopyranoside and 3-O-β-D-glucopyranosyl (1 → 4)-β-D-fucopyranosyl-(22S,24Z)-cycloart-24-en-3β,22,26,29-tetraol 26-O-β-D-glucopyranoside by extensive 1D and 2D NMR methods, HR-ESI-MS, and hydrolysis. Their cytotoxic activities toward human hepatoma Bel-7402 cells, human colon carcinoma LoVo cells, and human non-small-cell lung cancer NCIH-460 cells were evaluated by MTT assay, respectively.
authors.affiliation: Guangdong Research Institute of Traditional Chinese Medicine, Guangzhou 510520, China.
authors.forename: Xian-Tao
authors.initials: XT
authors.lastname: Zhang
authors.forename: Shu-Wei
authors.initials: SW
authors.lastname: Ma
authors.forename: Hao-Yan
authors.initials: HY
authors.lastname: Jiao
authors.forename: Qing-Wen
authors.initials: QW
authors.lastname: Zhang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031949:Thalictrum / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: C571636:3-O-beta-D-glucopyranosyl(1-4)-beta-D-fucopyranosyl-(22S,24Z)-cycloart-24-en-3beta,22,26,29-tetraol 26-O-beta-D-glucopyranoside; C571635:3-O-beta-D-glucopyranosyl(1-4)-beta-D-fucopyranosyl-(22S,24Z)-cycloart-24-en-3beta,22,26,30-tetraol 26-O-beta-D-glucopyranoside; D000972:Antineoplastic Agents, Phytogenic; D004365:Drugs, Chinese Herbal; D012503:Saponins; D014315:Triterpenes; C085352:cycloartane