title: [DNA-signaling pathway mediating development of a radiation-induced bystander effect in human cells].
abstract: Low doses of ionizing radiation induce the adaptive effect (AE) development in human cells which is followed by a number of cell responses. These responses can be transmitted from irradiated cells to non-irradiated ones (bystander effect, BE). The major role in radiation-induced BE is played by an oxidative stress (OS) and a DNA-signaling pathway, in which extracellular DNA fragments (ecDNA) are the factors of stress-signalization. We propose the following sequence of events in this signaling system: irradiation-OS-DNA modification-apoptosis of irradiated cells-ecDNA-signal acceptance by non-irradiated cells-OS-DNA modification, etc. We observed a radiation-induced BE which is accompanied by DNA-signaling pathway in differentiated and undifferentiated human cells forming monolayer or suspension cultures. Here we discuss several aspects of the radiation-induced BE mechanism and its persistence possibilities.
authors.forename: A V
authors.initials: AV
authors.lastname: Ermakov
authors.forename: M S
authors.initials: MS
authors.lastname: Kon'kova
authors.forename: S V
authors.initials: SV
authors.lastname: Kostiuk
authors.forename: N N
authors.initials: NN
authors.lastname: Veĭko
mesh_terms: D000222:Adaptation, Physiological; D017209:Apoptosis / Q000528:radiation effects; D024201:Bystander Effect / Q000502:physiology*; D002454:Cell Differentiation / Q000528:radiation effects; D002478:Cells, Cultured; D004247:DNA / Q000737:chemistry / Q000378:metabolism* / Q000528:radiation effects*; D004249:DNA Damage; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D018384:Oxidative Stress; D011839:Radiation, Ionizing; D015398:Signal Transduction
chemical_list: D004247:DNA