title: [The correlation between the level of serum VEGF and bFGF with metastasis and prognosis of osteosarcoma].
abstract: OBJECTIVE
  To investigate the correlation between the level of serum VEGF and bFGF with metastasis and re- currence of osteosarcoma.
  
  
  METHODS
  52 patients with osteosarcoma and 60 healthy people as control group were selected. The serum contents of VEGF and bFGF were determined with ELISA before and after operation.
  
  
  RESULTS
  The serum contents of VEGF and bFGF before operation were significantly higher than that in control group ( P < 0.01). The serum contents of VEGF and bFGF after operation descreased significantly but were significantly higher than that in control group(P<0. 01). The serum contents of VEGF and bFGF before operation were positively related to the size of primarily tumor, Enneking type and tumor differentiation(P<0.05). The serum contents of VEGF and bFGF before and after operation were different significantly between recurrence and metastasis positive group with recurrence and metastasis negative group ( P < 0. 01). The Cox proportional hazards model showed that the serum contents of VEGF and bFGF before and after operation were an independent factor of the recurrence and metastasis for osteosar- coma patients after operative ( P <0. 01).
  
  
  CONCLUSIONS
  The serum contents of VEGF and bFGF before and after operation can offer valuable assessments in evaluation of progression and metastasis prognosis.
authors.affiliation: Department of Clinical Medicine, Medical College of Putian University, Putian 351100, China. ggllchen@163.com
authors.forename: Guo-li
authors.initials: GL
authors.lastname: Chen
authors.forename: Hai-bin
authors.initials: HB
authors.lastname: Lin
authors.forename: Xian-wei
authors.initials: XW
authors.lastname: Wu
authors.forename: Rong-yi
authors.initials: RY
authors.lastname: Li
authors.forename: Xuan-huang
authors.initials: XH
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000097:blood / Q000473:pathology*; D002648:Child; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000097:blood; D012516:Osteosarcoma / Q000097:blood / Q000556:secondary*; D011379:Prognosis; D042461:Vascular Endothelial Growth Factor A / Q000097:blood*
chemical_list: D042461:Vascular Endothelial Growth Factor A; D016222:Fibroblast Growth Factor 2