title: Preparation of biodegradable polylactide microparticles via a biocompatible procedure.
abstract: PLA MPs are prepared via a novel and toxic-chemical-free fabrication route using ethyl lactate, a green solvent and FDA-approved aroma. MPs are obtained by a solution jet break-up and solvent displacement method. Adjusting flow parameters allows the tuning of MPs size between 60 and 180 µm, with reduced polydispersity. Morphological analysis shows microporous particles with Janus-like surface. A fluorophore is successfully loaded into the MPs during their formation step. This versatile green solvent-based procedure is proven to be suitable for drug encapsulation and delivery applications. The method may be extended to different droplet generation techniques.
authors.affiliation: Institute for Bioengineering of Catalonia (IBEC) and CIBER en Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Edifici Helix, C/Baldiri Reixac 15-21, 08028 Barcelona, Spain.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Levato
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Mateos-Timoneda
authors.forename: Josep A
authors.initials: JA
authors.lastname: Planell
mesh_terms: D001672:Biocompatible Materials; D004337:Drug Carriers / Q000138:chemical synthesis*; D004339:Drug Compounding; D005456:Fluorescent Dyes; D055772:Green Chemistry Technology; D006801:Humans; D007773:Lactates / Q000737:chemistry; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D010316:Particle Size; D011091:Polyesters / Q000737:chemistry*; D016062:Porosity; D012235:Rhodamines; D012997:Solvents; D014783:Viscosity
chemical_list: D001672:Biocompatible Materials; D004337:Drug Carriers; D005456:Fluorescent Dyes; D007773:Lactates; D011091:Polyesters; D012235:Rhodamines; D012997:Solvents; C033616:poly(lactide); C015866:ethyl lactate; C029773:rhodamine B