title: Serum deoxyribonuclease I activity can be a useful diagnostic marker for the early diagnosis of unstable angina pectoris or non-ST-segment elevation myocardial infarction.
abstract: OBJECTIVE
  Recently, serum deoxyribonuclease I (DNase I) activity has been highlighted as a potential diagnostic marker for transient myocardial ischemia. To evaluate whether serum DNase I activity can be a useful biomarker for diagnosing unstable angina pectoris (UAP) or non-ST-segment elevation myocardial infarction (NSTEMI), we investigated serial changes in DNase I levels after chest pain in UAP and NSTEMI (UAP/NSTEMI) patients.
  
  
  RESULTS
  Thirty-three and ten patients classified into the UAP/NSTEMI and the chest pain syndrome (CPS) group, respectively, were enrolled. The serum DNase I activity levels within 3h after chest pain and the absolute median value of percentage differences in serum DNase I activity levels from admission to 3h after hospitalization in the UAP/NSTEMI patients was significantly higher than those in the CPS patients. We evaluated the patients to show positive results for DNase I activity if the serum levels or percentage differences exceeded the corresponding cut-off values. The sensitivity and specificity of DNase I within 6h after chest pain in the UAP/NSTEMI patients without elevated levels of cardiac troponin T and the MB isoenzyme of creatine kinase were 89% and 88%, respectively.
  
  
  CONCLUSIONS
  Serum DNase I activity can be a useful marker for the early diagnosis of UAP/NSTEMI after the onset of chest pain, irrespective of the evidence of myocardial injury.
authors.affiliation: Department of Cardiology, Kanazawa Medical University, Kahoku, Ishikawa, Japan.
authors.forename: Kousuke
authors.initials: K
authors.lastname: Fujibayashi
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Kawai
authors.forename: Michihiko
authors.initials: M
authors.lastname: Kitayama
authors.forename: Hironubu
authors.initials: H
authors.lastname: Akao
authors.forename: Ryoko
authors.initials: R
authors.lastname: Ishida
authors.forename: Atsushi
authors.initials: A
authors.lastname: Motoyama
authors.forename: Minoru
authors.initials: M
authors.lastname: Wakasa
authors.forename: Kenichiro
authors.initials: K
authors.lastname: Arakawa
authors.forename: Misuzu
authors.initials: M
authors.lastname: Ueki
authors.forename: Kouji
authors.initials: K
authors.lastname: Kajinami
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Yasuda
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000789:Angina, Unstable / Q000175:diagnosis*; D015415:Biomarkers / Q000097:blood; D002637:Chest Pain; D003850:Deoxyribonuclease I / Q000097:blood*; D042241:Early Diagnosis; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis*; D013997:Time Factors
chemical_list: D015415:Biomarkers; D003850:Deoxyribonuclease I