title: [Protein kinase C and morphine tolerance].
abstract: Protein kinase C (PKC) belongs to the AGC (cAMP-dependent protein kinase/PKG/PKC) protein kinase family which plays an important role in the morphine-induced desensitization of R-opioid receptors. This cellular process is believed to contribute to the development and maintenance of morphine tolerance. Therefore, the study of PKC signaling transduction on morphine tolerance has an important clinical significance. The present review summarizes the possible involvement of PKC in opioid tolerance.
authors.affiliation: Key Laboratory of Developmental Biology and Neuroscience in Fujian Province, College of Life Sciences, Fujian Normal University, Fuzhou 350108, China.
authors.forename: Yu-Ping
authors.initials: YP
authors.lastname: Huo
authors.forename: Yan-Guo
authors.initials: YG
authors.lastname: Hong
mesh_terms: D000701:Analgesics, Opioid / Q000494:pharmacology; D000818:Animals; D004361:Drug Tolerance; D006801:Humans; D009020:Morphine / Q000494:pharmacology*; D011493:Protein Kinase C / Q000502:physiology*; D017450:Receptors, Opioid, mu / Q000378:metabolism*
chemical_list: D000701:Analgesics, Opioid; D017450:Receptors, Opioid, mu; D009020:Morphine; D011493:Protein Kinase C