title: Aspirin-exacerbated respiratory disease in China: a cohort investigation and literature review.
abstract: BACKGROUND
  Although the prevalence of aspirin-exacerbated respiratory disease (AERD) in western populations is high, AERD is rather rare in China, and few related studies have been published to date.
  
  
  METHODS
  We performed a prospective cohort investigation  on the incidence of AERD in patients with chronic rhinosinusitis (CRS) in southern China. A literature search of the China Academic Journal Network Publishing Database was conducted to obtain an overview of the incidence of AERD in the Chinese population, and previous studies on the incidence  of AERD were reviewed.
  
  
  RESULTS
  We found 2 patients with aspirin hypersensitivity among 351 consecutive CRS (309 with nasal polyps [NPs]) patients, suggesting a rate of 0.57% in the CRS population. Forty-five articles about AERD were obtained by Chinese-language literature  searches. In total, 346 cases of AERD were reported during the past 30 years.
  
  
  CONCLUSIONS
  Given the large population of NPs in China, the prevalence of AERD is very low, and this may be related to the reduced levels of nasal tissue eosinophilia and subsequent low asthma  comorbidity.
authors.affiliation: Allergy and Cancer Center, Otorhinolaryngology Hospital, First Affiliated Hospital of Sun Yat-sen University, No. 58 Zhongshan 2nd Road, Guangzhou, China.
authors.forename: Yunping
authors.initials: Y
authors.lastname: Fan
authors.forename: Shaoyan
authors.initials: S
authors.lastname: Feng
authors.forename: Wentong
authors.initials: W
authors.lastname: Xia
authors.forename: Lijuan
authors.initials: L
authors.lastname: Qu
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Li
authors.forename: Shulin
authors.initials: S
authors.lastname: Chen
authors.forename: Minhong
authors.initials: M
authors.lastname: Ding
authors.forename: Yinyan
authors.initials: Y
authors.lastname: Lai
authors.forename: Jianbo
authors.initials: J
authors.lastname: Shi
authors.forename: Geng
authors.initials: G
authors.lastname: Xu
authors.forename: Huabin
authors.initials: H
authors.lastname: Li
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D055963:Asthma, Aspirin-Induced / Q000150:complications / Q000453:epidemiology* / Q000503:physiopathology; D002681:China; D002908:Chronic Disease; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000175:diagnosis* / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology; D015995:Prevalence; D012220:Rhinitis / Q000150:complications / Q000453:epidemiology* / Q000503:physiopathology; D012852:Sinusitis / Q000150:complications / Q000453:epidemiology* / Q000503:physiopathology; D055815:Young Adult