title: Thematic minireview series: Metals in Biology 2012.
abstract: Metals are present in about one-half of the protein structures available and also have critical roles in nucleic acid biochemistry. This prologue introduces the fourth of the Thematic Minireview Series on Metals in Biology, which deals with several topics involving iron, manganese, copper, and other metals. The six minireviews discuss metal transport and intracellular homeostasis, including chaperones and siderophores, maturation of the diiron active sites in hydrogenases, the balance between manganese and iron, and copper homeostasis relevant to pathogens.
authors.affiliation: Department of Biochemistry and Center in Molecular Toxicology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, USA. f.guengerich@vanderbilt.edu
authors.forename: F Peter
authors.initials: FP
authors.lastname: Guengerich
mesh_terms: D000818:Animals; D020134:Catalytic Domain; D003300:Copper / Q000737:chemistry; D006706:Homeostasis; D006801:Humans; D006864:Hydrogenase / Q000737:chemistry; D007501:Iron / Q000737:chemistry; D054834:Lipocalins / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism; D008345:Manganese / Q000737:chemistry; D008670:Metals / Q000737:chemistry*; D008954:Models, Biological; D017262:Siderophores / Q000737:chemistry
chemical_list: D054834:Lipocalins; D008670:Metals; D017262:Siderophores; D008345:Manganese; D003300:Copper; D007501:Iron; D006864:Hydrogenase