title: Porous polysulfone coatings for enhanced drug delivery.
abstract: The synthesis of a porous polysulfone (PSU) coating for use in drug delivery applications is presented. PSU can serve as a functional surface coating for drug delivery vehicles, such as intraocular biomicrorobots. The coatings can be applied using spin coating or dip coating. The porosity is introduced by selectively dissolving calcium carbonate nanoparticles embedded in the bulk polymer. The network of pores thus formed increases by a factor of thirty the amount of Rhodamine B (model drug) that can be loaded and by a factor of fifteen the amount that can be released. The films do not affect cell viability and exhibit poor cell adhesion. The straightforward synthesis and predictability of porosity enables the tuning of the amount of drug that can be loaded.
authors.affiliation: Multi Scale Robotics Lab, Institute of Robotics and Intelligent Systems-IRIS, ETH Zurich, Zurich 8092, Switzerland. kartiks@ethz.ch
authors.forename: Kartik M
authors.initials: KM
authors.lastname: Sivaraman
authors.forename: Christoph
authors.initials: C
authors.lastname: Kellenberger
authors.forename: Salvador
authors.initials: S
authors.lastname: Pané
authors.forename: Olgaç
authors.initials: O
authors.lastname: Ergeneman
authors.forename: Tessa
authors.initials: T
authors.lastname: Lühmann
authors.forename: Norman A
authors.initials: NA
authors.lastname: Luechinger
authors.forename: Heike
authors.initials: H
authors.lastname: Hall
authors.forename: Wendelin J
authors.initials: WJ
authors.lastname: Stark
authors.forename: Bradley J
authors.initials: BJ
authors.lastname: Nelson
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D002119:Calcium Carbonate / Q000378:metabolism; D002448:Cell Adhesion; D002478:Cells, Cultured; D016503:Drug Delivery Systems / Q000379:methods*; D006801:Humans; D008856:Microscopy, Fluorescence; D055616:Microtechnology / Q000379:methods; D053758:Nanoparticles / Q000737:chemistry; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*; D016062:Porosity; D012235:Rhodamines / Q000737:chemistry; D013450:Sulfones / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D011108:Polymers; D012235:Rhodamines; D013450:Sulfones; C017662:polysulfone P 1700; D002119:Calcium Carbonate; C029773:rhodamine B