title: Successful treatment of right-sided native valve methicillin-resistant Staphylococcus aureus endocarditis and septicaemia with teicoplanin and rifampicin: a case report.
abstract: Vancomycin is the drug of choice in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infection. However, the presence of certain clinical complications like renal failure alters vancomycin pharmacokinetics, leading to drug accumulation and toxicity. This highlights the need to identify an effective substitute for treating MRSA infections when vancomycin cannot be used. We report the case of a 57-y-old Indian male diagnosed with tricuspid valve endocarditis with septicaemia and a right upper lobe cavity caused by MRSA. The patient also presented with renal failure, which precluded the use of vancomycin for treatment. A 6-week regimen of teicoplanin and rifampicin was used instead, and the infection was successfully treated. This case report provides evidence of the effectiveness of teicoplanin and rifampicin in the treatment of MRSA bacteraemia in situations where the use of vancomycin is contraindicated.
authors.affiliation: Department of Internal Medicine, Kasturba Medical College, Manipal University, Karnataka, India. kavithasaravu@gmail.com
authors.forename: Kavitha
authors.initials: K
authors.lastname: Saravu
authors.forename: Chiranjay
authors.initials: C
authors.lastname: Mukhopadhyay
authors.forename: Vishwanath
authors.initials: V
authors.lastname: Satyanarayanan
authors.forename: Ananth
authors.initials: A
authors.lastname: Pai
authors.forename: Ashok Sebastian
authors.initials: AS
authors.lastname: Komaranchath
authors.forename: Frenil
authors.initials: F
authors.lastname: Munim
authors.forename: Barkur Ananthakrishna
authors.initials: BA
authors.lastname: Shastry
authors.forename: Devasia
authors.initials: D
authors.lastname: Tom
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D004359:Drug Therapy, Combination / Q000379:methods; D004697:Endocarditis, Bacterial / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D007194:India; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000302:isolation & purification*; D008875:Middle Aged; D051437:Renal Insufficiency / Q000150:complications; D012293:Rifampin / Q000008:administration & dosage*; D018805:Sepsis / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000382:microbiology; D017334:Teicoplanin / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D017334:Teicoplanin; D012293:Rifampin