title: Tyrosine phosphorylation and bacterial virulence.
abstract: Protein phosphorylation on tyrosine has emerged as a key device in the control of numerous cellular functions in bacteria. In this article, we review the structure and function of bacterial tyrosine kinases and phosphatases. Phosphorylation is catalyzed by autophosphorylating adenosine triphosphate-dependent enzymes (bacterial tyrosine (BY) kinases) that are characterized by the presence of Walker motifs. The reverse reaction is catalyzed by three classes of enzymes: the eukaryotic-like phosphatases (PTPs) and dual-specific phosphatases; the low molecular weight protein-tyrosine phosphatases (LMW-PTPs); and the polymerase-histidinol phosphatases (PHP). Many BY kinases and tyrosine phosphatases can utilize host cell proteins as substrates, thereby contributing to bacterial pathogenicity. Bacterial tyrosine phosphorylation/dephosphorylation is also involved in biofilm formation and community development. The Porphyromonas gingivalis tyrosine phosphatase Ltp1 is involved in a restraint pathway that regulates heterotypic community development with Streptococcus gordonii. Ltp1 is upregulated by contact with S. gordonii and Ltp1 activity controls adhesin expression and levels of the interspecies signal AI-2.
authors.affiliation: School of Dentistry, University of Louisville, Louisville, KY, USA.
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Whitmore
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Lamont
mesh_terms: D001419:Bacteria / Q000201:enzymology*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D018441:Biofilms / Q000254:growth & development*; D015964:Gene Expression Regulation, Bacterial; D054884:Host-Pathogen Interactions; D010766:Phosphorylation; D011135:Polysaccharides, Bacterial / Q000096:biosynthesis*; D016966:Porphyromonas gingivalis / Q000201:enzymology; D011499:Protein Processing, Post-Translational; D017434:Protein Structure, Tertiary; D017027:Protein Tyrosine Phosphatases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D011505:Protein-Tyrosine Kinases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D053038:Quorum Sensing; D015398:Signal Transduction; D054773:Streptococcus gordonii / Q000201:enzymology; D037521:Virulence Factors / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D011135:Polysaccharides, Bacterial; D037521:Virulence Factors; D011505:Protein-Tyrosine Kinases; D017027:Protein Tyrosine Phosphatases