title: Association of human leukocyte antigen-DRB1 alleles with chronic hepatitis             B virus infection in the Han Chinese of Northeast China.
abstract: Human leukocyte antigen (HLA) class II molecule is an integral component of the immune response on which the majority of host genetic studies have concentrated. Many different HLA-II alleles have been demonstrated to play roles in HBV infection. PCR-SSOP methods were applied to determine the HLA-DRB1 genotypes of 769 unrelated healthy individuals from Han Chinese of Northeast China. The frequencies of HLA-DRB1*09 in hepatitis B virus (HBV)-infected subjects were higher compared to those in the control group. Frequencies of HLA-DRB1*04 and *13 in the HBV-infected group were significantly lower compared to those in the healthy control group. Frequencies of HLA-DRB1*12 in the cirrhosis and liver cancer groups were significantly higher than those in the chronic hepatitis B (CHB) patients. The frequency of LA-DRB1*03 in the CHB patient group was significantly higher compared to that in the asymptomatic hepatitis B carrier patients. The above results suggest that the host HLA-II gene is an important factor in the determination of the outcome of HBV infection.
authors.affiliation: Jilin Blood Center, Changchun, Jilin 130033, PR China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Han
authors.forename: Zhen-Yu
authors.initials: ZY
authors.lastname: Jiang
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Jiao
authors.forename: Cheng
authors.initials: C
authors.lastname: Yao
authors.forename: Qian-Fei
authors.initials: QF
authors.lastname: Lin
authors.forename: Ning
authors.initials: N
authors.lastname: Ma
authors.forename: Rui-Qing
authors.initials: RQ
authors.lastname: Ju
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.forename: Jiang-Hong
authors.initials: JH
authors.lastname: Yu
authors.forename: Lin
authors.initials: L
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D044466:Asian People / Q000208:ethnology; D002681:China / Q000453:epidemiology / Q000208:ethnology; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D059811:HLA-DRB1 Chains / Q000235:genetics* / Q000276:immunology; D006515:Hepatitis B virus; D019694:Hepatitis B, Chronic / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology; D006801:Humans; D008103:Liver Cirrhosis / Q000453:epidemiology / Q000235:genetics / Q000276:immunology / Q000821:virology; D008297:Male; D008875:Middle Aged
chemical_list: D059811:HLA-DRB1 Chains; C527195:HLA-DRB1*04 antigen