title: Age associated differences in prevalence of individual rotterdam criteria and metabolic risk factors during reproductive age in 446 caucasian women with polycystic ovary syndrome.
abstract: Clinical manifestations and metabolic risk factors may differ according to age in patients with polycystic ovary syndrome (PCOS). Therefore, a retrospective trans-sectional study in academic tertiary-care medical center was designed. A cohort of 446 premenopausal, Caucasian women (age range 15-49 years) with PCOS were divided into 4 subgroups according to age: group 1 (15-19 years, n=42), group 2 (20-29 years, n=180), group 3 (30-39 years, n=187), group 4 (40-49 years, n=37) and underwent clinical evaluation (Ferriman-Gallwey score, BMI, waist, blood pressure), hormone analyses (sex hormones, fasting lipids, insulin, glucose), transvaginal ultrasound, oral glucose tolerance tests (OGTT) (n=234), and ACTH tests (n=201). BMI, waist, Ferriman-Gallwey score, blood pressure, and lipid profile were higher in older vs. younger age groups whereas androgen levels were lower. Measures of insulin resistance were unchanged between age groups, but glucose levels were significantly higher in older age groups. Rotterdam criteria: The prevalence of PCO and biochemical hyperandrogenism decreased in the oldest age group whereas clinical hyperandrogenism increased. Young patients are characterized by PCO and biochemical hyperandrogenism, whereas older patients are more obese with more severe hirsutism and more cardiovascular and metabolic risk factors.
authors.affiliation: Department of Endocrinology and Metabolism, Odense University Hospital, Odense C, Denmark. d.glintborg@gmail.com
authors.forename: D
authors.initials: D
authors.lastname: Glintborg
authors.forename: H
authors.initials: H
authors.lastname: Mumm
authors.forename: P
authors.initials: P
authors.lastname: Ravn
authors.forename: M
authors.initials: M
authors.lastname: Andersen
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001786:Blood Glucose / Q000032:analysis; D003718:Denmark / Q000453:epidemiology; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D008659:Metabolic Diseases / Q000453:epidemiology* / Q000378:metabolism; D024821:Metabolic Syndrome; D008875:Middle Aged; D011085:Polycystic Ovary Syndrome / Q000175:diagnosis / Q000378:metabolism* / Q000503:physiopathology; D015995:Prevalence; D012098:Reproduction; D012189:Retrospective Studies; D012307:Risk Factors; D044465:White People; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D007328:Insulin