title: Variation in DNA repair gene XRCC3 affects  susceptibility to astrocytomas and glioblastomas.
abstract: The gene XRCC3 (X-ray cross complementing group 3) has  the task of repairing damage that occurs when there is recombination between  homologous chromosomes. Repair of recombination between homologous chromosomes  plays an important role in maintaining genome integrity, although it is known  that double-strand breaks are the main inducers of chromosomal aberrations.  Changes in the XRCC3 protein lead to an increase in errors in chromosome  segregation due to defects in centrosomes, resulting in aneuploidy and other  chromosomal aberrations, such as small increases in telomeres. We examined  XRCC3 Thr241Met polymorphism using PCR-RFLP in 80 astrocytoma and glioblastoma  samples. The individuals of the control group (N = 100) were selected from the  general population of the São Paulo State. Odds ratio and 95%CI were calculated  using a logistic regression model. Patients who had the allele Met of the XRCC3  Thr241Met polymorphism had a significantly increased risk of tumor development  (odds ratio = 3.13; 95% confidence interval = 1.50-6.50). There were no  significant differences in overall survival of patients. We suggest that XRCC3  Thr241Met polymorphism is involved in susceptibility for developing  astrocytomas and glioblastomas.
authors.affiliation: Laboratório de Oncogenética, Departamento de Genética, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP, Brasil. alinecadurin@yahoo.com.br
authors.forename: A C
authors.initials: AC
authors.lastname: Custódio
authors.forename: L O
authors.initials: LO
authors.lastname: Almeida
authors.forename: G R
authors.initials: GR
authors.lastname: Pinto
authors.forename: M J
authors.initials: MJ
authors.lastname: Santos
authors.forename: J R W
authors.initials: JR
authors.lastname: Almeida
authors.forename: C A
authors.initials: CA
authors.lastname: Clara
authors.forename: J A
authors.initials: JA
authors.lastname: Rey
authors.forename: C
authors.initials: C
authors.lastname: Casartelli
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D001254:Astrocytoma / Q000235:genetics*; D018385:Centrosome / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D020090:Chromosome Segregation / Q000235:genetics; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D005909:Glioblastoma / Q000235:genetics*; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D055815:Young Adult
chemical_list: D004268:DNA-Binding Proteins; C110901:X-ray repair cross complementing protein 3