title: Bioactive hydroperoxyl cembranoids from the Red Sea soft coral Sarcophyton glaucum.
abstract: A chemical investigation of an ethyl acetate extract of the Red Sea soft coral Sarcophyton glaucum has led to the isolation of two peroxide diterpenes, 11(S) hydroperoxylsarcoph-12(20)-ene (1), and 12(S)-hydroperoxylsarcoph-10-ene (2), as well as 8-epi-sarcophinone (3). In addition to these three new compounds, two known structures were identified including: ent-sarcophine (4) and sarcophine (5). Structures were elucidated by spectroscopic analysis, with the relative configuration of 1 and 2 confirmed by X-ray diffraction. Isolated compounds were found to be inhibitors of cytochrome P₄₅₀ 1A activity as well as inducers of glutathione S-transferases (GST), quinone reductase (QR), and epoxide hydrolase (mEH) establishing chemo-preventive and tumor anti-initiating activity for these characterized metabolites.
authors.affiliation: Chemistry of Medicinal Plants Department, and Center of Excellence for Advanced Sciences, National Research Centre, El-Tahrir Street, Dokki, Giza 12622, Egypt.
authors.forename: Mohamed-Elamir F
authors.identifier: 0000-0002-0343-4969
authors.initials: MF
authors.lastname: Hegazy
authors.affiliation: Cancer Biology Lab, Center of Excellence for Advanced Sciences, and Biochemistry Department, National Research Center, Dokki Cairo 12622, Egypt.
authors.forename: Amira M Gamal
authors.initials: AMG
authors.lastname: Eldeen
authors.affiliation: Chemistry of Medicinal Plants Department, and Center of Excellence for Advanced Sciences, National Research Centre, El-Tahrir Street, Dokki, Giza 12622, Egypt.|Medicinal, Aromatic and Poisonous Plants Research Center, College of Pharmacy, King Saudi University, PO Box 2457, Riyadh 11451, Saudi Arabia.
authors.forename: Abdelaaty A
authors.initials: AA
authors.lastname: Shahat
authors.affiliation: Department of Chemistry, Faculty of Science, Minia University, El-Minia 61519, Egypt.
authors.forename: Fathy F
authors.initials: FF
authors.lastname: Abdel-Latif
authors.affiliation: Chemistry of Medicinal Plants Department, and Center of Excellence for Advanced Sciences, National Research Centre, El-Tahrir Street, Dokki, Giza 12622, Egypt.
authors.forename: Tarik A
authors.initials: TA
authors.lastname: Mohamed
authors.affiliation: Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA.
authors.forename: Bruce R
authors.initials: BR
authors.lastname: Whittlesey
authors.affiliation: Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA.
authors.forename: Paul W
authors.identifier: 0000-0003-1644-723X
authors.initials: PW
authors.lastname: Paré
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D016588:Anticarcinogenic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002942:Circular Dichroism; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019156:Indian Ocean; D009682:Magnetic Resonance Spectroscopy; D014961:X-Ray Diffraction
chemical_list: D016588:Anticarcinogenic Agents; D004224:Diterpenes