title: Selective alkylation of (hetero)aromatic amines with alcohols catalyzed by a ruthenium pincer complex.
abstract: A readily available pincer ruthenium(II) complex catalyzes the selective monoalkylation of (hetero)aromatic amines with a wide range of primary alcohols (including pyridine-, furan-, and thiophene-substituted alcohols) with high efficiency when used in low catalyst loadings (1 mol %). Tertiary amine formation via polyalkylation does not occur, making this ruthenium system an excellent catalyst for the synthesis of sec-amines.
authors.affiliation: Department of Organic Chemistry, The Arrhenius Laboratory, Stockholm University, SE 106 91 Stockholm, Sweden.
authors.forename: Santosh
authors.initials: S
authors.lastname: Agrawal
authors.forename: Maud
authors.initials: M
authors.lastname: Lenormand
authors.forename: Belén
authors.initials: B
authors.lastname: Martín-Matute
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D000478:Alkylation; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D012428:Ruthenium / Q000737:chemistry*
chemical_list: D000438:Alcohols; D000588:Amines; D012428:Ruthenium