title: A mathematical model of the process of ligament repair: effect of cold therapy and mechanical stress.
abstract: This article proposes a mathematical model that predicts the wound healing process of the ligament after a sprain, grade II. The model describes the swelling, expression of the platelet-derived growth factor (PDGF), formation and migration of fibroblasts into the injury area and the expression of collagen fibers. Additionally, the model can predict the effect of ice treatment in reducing inflammation and the action of mechanical stress in the process of remodeling of collagen fibers. The results obtained from computer simulation show a high concordance with the clinical data previously reported by other authors.
authors.affiliation: Facultad de Ingeniería, Universidad Nacional de Colombia, Grupo de Modelado y Métodos Numéricos en Ingeniería (GNUM), Cra 30 45-03, Ed 407, Of 202, Bogotá, Colombia.
authors.forename: Rosy Paola
authors.initials: RP
authors.lastname: Cárdenas Sandoval
authors.forename: Diego Alexander
authors.initials: DA
authors.lastname: Garzón-Alvarado
authors.forename: Angélica Maria
authors.initials: AM
authors.lastname: Ramírez Martínez
mesh_terms: D003094:Collagen / Q000378:metabolism; D017679:Cryotherapy / Q000379:methods*; D006801:Humans; D008023:Ligaments, Articular / Q000293:injuries* / Q000378:metabolism / Q000502:physiology; D008954:Models, Biological; D013180:Sprains and Strains / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy; D013314:Stress, Mechanical; D014945:Wound Healing / Q000502:physiology*
chemical_list: D003094:Collagen