title: Genome-wide association analysis of ischemic stroke in young adults.
abstract: Ischemic stroke (IS) is among the leading causes of death in Western countries. There is a significant genetic component to IS susceptibility, especially among young adults. To date, research to identify genetic loci predisposing to stroke has met only with limited success. We performed a genome-wide association (GWA) analysis of early-onset IS to identify potential stroke susceptibility loci. The GWA analysis was conducted by genotyping 1 million SNPs in a biracial population of 889 IS cases and 927 controls, ages 15-49 years. Genotypes were imputed using the HapMap3 reference panel to provide 1.4 million SNPs for analysis. Logistic regression models adjusting for age, recruitment stages, and population structure were used to determine the association of IS with individual SNPs. Although no single SNP reached genome-wide significance (P < 5 × 10(-8)), we identified two SNPs in chromosome 2q23.3, rs2304556 (in FMNL2; P = 1.2 × 10(-7)) and rs1986743 (in ARL6IP6; P = 2.7 × 10(-7)), strongly associated with early-onset stroke. These data suggest that a novel locus on human chromosome 2q23.3 may be associated with IS susceptibility among young adults.
authors.forename: Yu-Ching
authors.initials: YC
authors.lastname: Cheng
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: O'Connell
authors.forename: John W
authors.initials: JW
authors.lastname: Cole
authors.forename: O Colin
authors.initials: OC
authors.lastname: Stine
authors.forename: Nicole
authors.initials: N
authors.lastname: Dueker
authors.forename: Patrick F
authors.initials: PF
authors.lastname: McArdle
authors.forename: Mary J
authors.initials: MJ
authors.lastname: Sparks
authors.forename: Jess
authors.initials: J
authors.lastname: Shen
authors.forename: Cathy C
authors.initials: CC
authors.lastname: Laurie
authors.forename: Sarah
authors.initials: S
authors.lastname: Nelson
authors.forename: Kimberly F
authors.initials: KF
authors.lastname: Doheny
authors.forename: Hua
authors.initials: H
authors.lastname: Ling
authors.forename: Elizabeth W
authors.initials: EW
authors.lastname: Pugh
authors.forename: Thomas G
authors.initials: TG
authors.lastname: Brott
authors.forename: Robert D
authors.initials: RD
authors.lastname: Brown
authors.forename: James F
authors.initials: JF
authors.lastname: Meschia
authors.forename: Michael
authors.initials: M
authors.lastname: Nalls
authors.forename: Stephen S
authors.initials: SS
authors.lastname: Rich
authors.forename: Bradford
authors.initials: B
authors.lastname: Worrall
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Anderson
authors.forename: Alessandro
authors.initials: A
authors.lastname: Biffi
authors.forename: Lynelle
authors.initials: L
authors.lastname: Cortellini
authors.forename: Karen L
authors.initials: KL
authors.lastname: Furie
authors.forename: Natalia S
authors.initials: NS
authors.lastname: Rost
authors.forename: Jonathan
authors.initials: J
authors.lastname: Rosand
authors.forename: Teri A
authors.initials: TA
authors.lastname: Manolio
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Kittner
authors.forename: Braxton D
authors.initials: BD
authors.lastname: Mitchell