title: Efficacy of an enterovaccine in recurrent episodes of diarrhea in the dog: a pilot study.
abstract: Recurrent episodes of self-limiting diarrhea in the dog, due to sudden dietary changes and to stressful or exciting situations, are conditions sometimes difficult to treat. Colifagina(®), a commercially available bacterial enterovaccine, showed, in previous studies performed on experimentally induced colitis in mice, to be able to improve both disease activity index and histological appearance, increase colonic secretion of IgA, and reduce inflammatory chemokine secretion. In the present study Colifagina(®) was administered to five dogs presenting recurrent episodes of self-limiting diarrhea and to one dog presenting chronic diarrhea. During the follow-up period, almost all patients decreased the number of episodes of abnormal defecation and the fecal score of such episodes improved in five out of six dogs. Even if further studies are needed to understand the exact potential of the compound, in dogs presenting recurrent episodes of self-limiting diarrhea due to sudden dietary changes and/or stressing or exciting situations, Colifagina(®) seems to be helpful in managing most of these patients.
authors.affiliation: School of Medical Veterinary Sciences, University of Camerino, Matelica, Italy. matteo.cerquetella@unicam.it
authors.forename: Matteo
authors.initials: M
authors.lastname: Cerquetella
authors.forename: Fulvio
authors.initials: F
authors.lastname: Laus
authors.forename: Fabiana
authors.initials: F
authors.lastname: Speranzini
authors.forename: Cristina
authors.initials: C
authors.lastname: Carnevali
authors.forename: Andrea
authors.initials: A
authors.lastname: Spaterna
authors.forename: Edda
authors.initials: E
authors.lastname: Battaglia
authors.forename: Gabrio
authors.initials: G
authors.lastname: Bassotti
mesh_terms: D000284:Administration, Oral; D000818:Animals; D003967:Diarrhea / Q000188:drug therapy / Q000662:veterinary*; D004285:Dogs; D004334:Drug Administration Schedule / Q000662:veterinary; D005260:Female; D008297:Male; D010865:Pilot Projects; D019936:Probiotics / Q000627:therapeutic use*; D012008:Recurrence; D016896:Treatment Outcome