title: Enteric hyperoxaluria, recurrent urolithiasis, and systemic oxalosis in patients with Crohn's disease.
abstract: BACKGROUND
  Prevalence of recurrent calcium-oxalate (CaOx) urolithiasis (UL) is up to fivefold higher in Crohn's disease than in the general population. Treatment options are scarce and the risk of recurrent UL or progressive renal CaOx deposition, (oxalosis) based early end-stage renal failure (ESRF), subsequent systemic oxalosis, and recurrence in the kidney graft is pronounced. We aimed to find proof that secondary hyperoxaluria is the main risk factor for the devastating course and correlates with intestinal oxalate absorption.
  
  
  METHODS
  24-h urines were collected and analyzed for urinary oxalate (Uox) in 27 pediatric (6-18 years) and 19 adult patients (20-62 years). In the 21 patients (8 adults and 13 children) with hyperoxaluria a [(13)C(2)]oxalate absorption test was performed under standardized dietary conditions.
  
  
  RESULTS
  Mean Uox was significantly higher in patients with UL or oxalosis (0.92 ± 0.57) compared with those without (0.53 ± 0.13 mmol/1.73 m(2)/24 h, p<0.05, normal < 0.5). Hyperoxaluria then significantly correlated with intestinal oxalate absorption (p< 0.05).
  
  
  CONCLUSIONS
  As UL/oxalosis has major implications for the general health in patients with Crohn's disease (ESRF and systemic oxalosis), new medication, e.g. to reduce intestinal oxalate absorption, is definitely needed.
authors.affiliation: Division of Pediatric Nephrology, Department of Pediatric and Adolescent Medicine, University Hospital Cologne, Kerpenerstrasse 62, 50924, Cologne, Germany.
authors.forename: Renate
authors.initials: R
authors.lastname: Hueppelshaeuser
authors.forename: Gerd E
authors.initials: GE
authors.lastname: von Unruh
authors.forename: Sandra
authors.initials: S
authors.lastname: Habbig
authors.forename: Bodo B
authors.initials: BB
authors.lastname: Beck
authors.forename: Stephan
authors.initials: S
authors.lastname: Buderus
authors.forename: Albrecht
authors.initials: A
authors.lastname: Hesse
authors.forename: Bernd
authors.initials: B
authors.lastname: Hoppe
mesh_terms: D000293:Adolescent; D000328:Adult; D002129:Calcium Oxalate / Q000378:metabolism*; D002648:Child; D003424:Crohn Disease / Q000150:complications* / Q000378:metabolism*; D005260:Female; D006801:Humans; D006959:Hyperoxaluria / Q000209:etiology* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D052878:Urolithiasis / Q000209:etiology* / Q000378:metabolism; D055815:Young Adult
chemical_list: D002129:Calcium Oxalate