title: miRNAs as potential therapeutic targets for age-related macular degeneration.
abstract: Since their recent discovery, miRNAs have been shown to play critical roles in a variety of pathophysiological processes. Such processes include pathological angiogenesis, the oxidative stress response, immune response and inflammation, all of which have been shown to have important and interdependent roles in the pathogenesis and progression of age-related macular degeneration (AMD). Here we present a brief review of the pathological processes involved in AMD and review miRNAs and other noncoding RNAs involved in regulating these processes. Specifically, we discuss several candidate miRNAs that show promise as AMD therapeutic targets due to their direct involvement in choroidal neovascularization or retinal pigment epithelium atrophy. We discuss potential miRNA-based therapeutics and delivery methods for AMD and provide future directions for the field of miRNA research with respect to AMD. We believe the future of miRNAs in AMD therapy is promising.
authors.affiliation: Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. shusheng.wang@utsouthwestern.edu
authors.forename: Shusheng
authors.initials: S
authors.lastname: Wang
authors.forename: Kyle M
authors.initials: KM
authors.lastname: Koster
authors.forename: Yuguang
authors.initials: Y
authors.lastname: He
authors.forename: Qinbo
authors.initials: Q
authors.lastname: Zhou
mesh_terms: D000818:Animals; D020256:Choroidal Neovascularization / Q000235:genetics / Q000473:pathology; D055808:Drug Discovery; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000235:genetics / Q000276:immunology; D008266:Macula Lutea / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D008268:Macular Degeneration / Q000235:genetics* / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D035683:MicroRNAs / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D018384:Oxidative Stress
chemical_list: D035683:MicroRNAs