title: Antioxidants of therapeutic relevance in COPD from the neotropical blueberry Anthopterus wardii.
abstract: Four flavone C-glycosides, isoorientin (1), orientin (2), vitexin (3), and isovitexin (4), were isolated from the neotropical blueberry of Anthopterus wardii, a so-called "superfruit", using antioxidant activity-guided fractionation. A dose-response relationship of compounds 1-4 was determined for their anti-inflammatory activity against interleukin-8 (IL-8) and for the inhibition of matrix metalloproteinase-1 (MMP-1) expression, an inflammatory marker for chronic obstructive pulmonary disease. The four flavone C-glycosides exhibited inhibitory activity against IL-8 production and MMP-1 expression, with compounds 1, 3, and 4 having the most potent inhibitory activities in both assays at 100 μg/ml. The structures of compounds 1-4 were determined by spectroscopic methods. These flavone C-glycosides are reported for the first time in the Anthopterus genus.
authors.affiliation: Department of Biological Sciences, Lehman College and The Graduate Center, City University of New York, 250 Bedford Park Boulevard West, Bronx, NY 10468, United States of America.
authors.forename: Gema
authors.initials: G
authors.lastname: Flores
authors.forename: Keyvan
authors.initials: K
authors.lastname: Dastmalchi
authors.forename: Abdoulaye J
authors.initials: AJ
authors.lastname: Dabo
authors.forename: Kathleen
authors.initials: K
authors.lastname: Whalen
authors.forename: Paola
authors.initials: P
authors.lastname: Pedraza-Peñalosa
authors.forename: Robert F
authors.initials: RF
authors.lastname: Foronjy
authors.forename: Jeanine M
authors.initials: JM
authors.lastname: D'Armiento
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Kennelly