title: Planar cell polarity protein localization in the secretory ameloblasts of rat incisors.
abstract: The localization of the planar cell polarity proteins Vang12, frizzled-3, Vang11, and Celsr1 in the rat incisors was examined using immunocytochemistry. The results showed that Vang12 was localized at two regions of the Tomes' processes of inner enamel-secretory ameloblasts in rat incisors: a proximal and a distal region. In contrast, frizzled-3 was localized at adherens junctions of the proximal and distal areas of inner enamel- and outer enamel-secretory ameloblasts, where N-cadherin and β-catenin were localized. frizzled-3 was also localized in differentiating inner enamel epithelial cells. Vang11 was localized sparsely in differentiating preameloblasts and extensively at the cell boundary of stratum intermedium. Celsr1 was not localized in ameloblasts but localized in odontoblasts extensively. These results suggest the involvement of planar cell polarity proteins in odontogenesis.
authors.affiliation: Department of Biology, Tsurumi University School of Dental Medicine, Tsurumi, Tsurumi-ku, Yokohama 230-8501, Japan. nishikawa-s@tsurumi-u.ac.jp
authors.forename: Sumio
authors.initials: S
authors.lastname: Nishikawa
authors.forename: Tadafumi
authors.initials: T
authors.lastname: Kawamoto
mesh_terms: D022005:Adherens Junctions / Q000378:metabolism; D000565:Ameloblasts / Q000166:cytology / Q000378:metabolism*; D000818:Animals; D015820:Cadherins / Q000378:metabolism*; D002454:Cell Differentiation; D016764:Cell Polarity; D051157:Frizzled Receptors / Q000378:metabolism*; D007150:Immunohistochemistry; D007180:Incisor / Q000166:cytology / Q000378:metabolism*; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D015820:Cadherins; D051157:Frizzled Receptors; D008565:Membrane Proteins