title: Galectin-1 inhibits the viability, proliferation, and Th1 cytokine production of nonmalignant T cells in patients with leukemic cutaneous T-cell lymphoma.
abstract: Tumor-derived galectin-1 (Gal-1), a β-galactoside-binding S-type lectin, has been shown to encourage T-cell death and promote T cell-mediated tumor immune escape. In this report, we show that patients with leukemic cutaneous T-cell lymphomas, known to have limited complexity of their T-cell repertoires, have a predominant T helper type-2 (Th2) cytokine profile and significantly elevated plasma levels of Gal-1 compared with healthy controls. Circulating clonal malignant T cells were a major source of Gal-1. The conditioned supernatant of cultured malignant T cells induced a β-galactoside-dependent inhibition of normal T-cell proliferation and a Th2 skewing of cytokine production. These data implicate Gal-1 in development of the Th2 phenotype in patients with advanced-stage cutaneous T-cell lymphoma and highlight the Gal-1-Gal-1 ligand axis as a potential therapeutic target for enhancing antitumor immune responses.
authors.affiliation: Department of Dermatology, Brigham and Women's Hospital, Boston, MA, USA.
authors.forename: Filiberto
authors.initials: F
authors.lastname: Cedeno-Laurent
authors.forename: Rei
authors.initials: R
authors.lastname: Watanabe
authors.forename: Jessica E
authors.initials: JE
authors.lastname: Teague
authors.forename: Thomas S
authors.initials: TS
authors.lastname: Kupper
authors.forename: Rachael A
authors.initials: RA
authors.lastname: Clark
authors.forename: Charles J
authors.initials: CJ
authors.lastname: Dimitroff
mesh_terms: D049109:Cell Proliferation; D002470:Cell Survival / Q000276:immunology; D002478:Cells, Cultured; D005260:Female; D005434:Flow Cytometry; D037483:Galectin 1 / Q000378:metabolism / Q000502:physiology*; D015973:Gene Expression Regulation, Leukemic; D006801:Humans; D015458:Leukemia, T-Cell / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D007963:Leukocytes, Mononuclear / Q000378:metabolism / Q000473:pathology / Q000502:physiology; D016410:Lymphoma, T-Cell, Cutaneous / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D012878:Skin Neoplasms / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D013601:T-Lymphocytes / Q000378:metabolism / Q000502:physiology*; D018417:Th1 Cells / Q000378:metabolism / Q000473:pathology / Q000502:physiology*
chemical_list: D037483:Galectin 1