title: Human papillomavirus genotype detection in recurrent respiratory papillomatosis (RRP) in Colombia.
abstract: BACKGROUND
  Knowledge on human papillomavirus (HPV) genotype distribution in recurrent respiratory papillomatosis (RRP) is essential to assess the impact of HPV vaccine. It is provided information for Colombia.
  
  
  METHODS
  In all, 189 RRP primary cases diagnosed between 1985 and 2009 were identified from 5 pathology laboratories of Cali and Medellin, Colombia. HPV DNA testing in 129 cases that fulfilled inclusion criteria (available paraffin blocks, amplifiable DNA, and confirmed histologic diagnosis of RRP) was performed by the SPF-10/LiPA25 assay (version 1).
  
  
  RESULTS
  Of all cases 36.1% were juvenile (<12 years old) and a majority of adults were males (p = .09); 95% of cases were HPV positive. HPV 6, 11, and 16 contributed to 69%, 27.1%, and 7.8% of all HPV positive cases. Twelve cases (9.3%) showed multiple infections; 8 of these were HPV 6 or 11 positive.
  
  
  CONCLUSIONS
  HPV prophylactic vaccine including HPV 6 and 11 may have a major impact against RRP.
authors.affiliation: Infection and Cancer Group, School of Medicine, University of Antioquia, Medellin, Colombia. sanchezg@medicina.udea.edu.co
authors.forename: Gloria I
authors.initials: GI
authors.lastname: Sanchez
authors.forename: Roberto
authors.initials: R
authors.lastname: Jaramillo
authors.forename: Gustavo
authors.initials: G
authors.lastname: Cuello
authors.forename: Katherine
authors.initials: K
authors.lastname: Quintero
authors.forename: Armando
authors.initials: A
authors.lastname: Baena
authors.forename: Adriana
authors.initials: A
authors.lastname: O'Byrne
authors.forename: Antonio Jose
authors.initials: AJ
authors.lastname: Reyes
authors.forename: Consuelo
authors.initials: C
authors.lastname: Santamaria
authors.forename: Harold
authors.initials: H
authors.lastname: Cuello
authors.forename: Anamaria
authors.initials: A
authors.lastname: Arrunategui
authors.forename: Armando
authors.initials: A
authors.lastname: Cortez
authors.forename: German
authors.initials: G
authors.lastname: Osorio
authors.forename: Julio Cesar
authors.initials: JC
authors.lastname: Reina
authors.forename: Wim G V
authors.initials: WG
authors.lastname: Quint
authors.forename: Nubia
authors.initials: N
authors.lastname: Muñoz
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003105:Colombia / Q000453:epidemiology; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology*; D005838:Genotype; D052140:Human papillomavirus 11 / Q000235:genetics / Q000302:isolation & purification*; D052163:Human papillomavirus 6 / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics* / Q000503:physiopathology; D053918:Papillomavirus Vaccines / Q000008:administration & dosage / Q000235:genetics; D016133:Polymerase Chain Reaction / Q000379:methods; D015995:Prevalence; D012141:Respiratory Tract Infections / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics* / Q000503:physiopathology; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D017678:Sex Distribution; D014505:Urban Population
chemical_list: D004279:DNA, Viral; D053918:Papillomavirus Vaccines