title: Carbazole alkaloids from the stems of Clausena lansium.
abstract: Ten new carbazole alkaloids, claulansines A-J (1-10), and seven known analogues (11-17) were isolated from the stems of Clausena lansium. Their structures were established on the basis of extensive spectroscopic analyses, and their absolute configurations were determined by CD experiments and computational methods. Screening results indicated that compounds 1, 6, 8-10, 13, 14, and 17 showed selective neuroprotective effects at the concentration of 10 μM.
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
authors.forename: Hang
authors.initials: H
authors.lastname: Liu
authors.forename: Chuang-Jun
authors.initials: CJ
authors.lastname: Li
authors.forename: Jing-Zhi
authors.initials: JZ
authors.lastname: Yang
authors.forename: Na
authors.initials: N
authors.lastname: Ning
authors.forename: Yi-Kang
authors.initials: YK
authors.lastname: Si
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Nai-Hong
authors.initials: NH
authors.lastname: Chen
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhao
authors.forename: Dong-Ming
authors.initials: DM
authors.lastname: Zhang
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D002227:Carbazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D054700:Clausena / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019906:Nuclear Magnetic Resonance, Biomolecular; D016716:PC12 Cells; D018547:Plant Stems / Q000737:chemistry; D051381:Rats
chemical_list: D000470:Alkaloids; D002227:Carbazoles; D004365:Drugs, Chinese Herbal; D018696:Neuroprotective Agents