title: Fluorescence turn-on detection of hypochlorous acid via HOCl-promoted dihydrofluorescein-ether oxidation and its application in vivo.
abstract: We report three new water-soluble dihydrofluorescein-ether probes FCN1, FCN2 and FCN3 for the detection of hypochlorous acid (HOCl), which were designed on the basis of a specific HOCl-promoted oxidation reaction. This work also provided a useful method to monitor the accumulated HOCl in specific organelles using a zebrafish model.
authors.affiliation: State Key Laboratory of Materials-Oriented Chemical Engineering and College of Science, Nanjing University of Technology, Nanjing 210009, PR China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zhou
authors.forename: Ju-Ying
authors.initials: JY
authors.lastname: Li
authors.forename: Kai-Hui
authors.initials: KH
authors.lastname: Chu
authors.forename: Ke
authors.initials: K
authors.lastname: Liu
authors.forename: Cheng
authors.initials: C
authors.lastname: Yao
authors.forename: Jing-Yun
authors.initials: JY
authors.lastname: Li
mesh_terms: D000818:Animals; D001923:Brain Chemistry; D004986:Ether / Q000737:chemistry*; D005452:Fluoresceins / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D006997:Hypochlorous Acid / Q000032:analysis* / Q000737:chemistry; D007422:Intestines / Q000737:chemistry; D051379:Mice; D041681:NIH 3T3 Cells; D010084:Oxidation-Reduction; D012995:Solubility; D014867:Water / Q000737:chemistry; D015027:Zebrafish / Q000196:embryology
chemical_list: D005452:Fluoresceins; D005456:Fluorescent Dyes; C110423:dihydrofluorescein; D014867:Water; D004986:Ether; D006997:Hypochlorous Acid