title: Disseminated kidney tuberculosis complicating autosomal dominant polycystic kidney disease: a case report.
abstract: Mycobacterium tuberculosis infection in patients with autosomal dominant polycystic kidney disease (ADPKD) is rare, and its diagnosis and treatment are difficult because numerous cysts are exposed to infection and antibiotics do not easily penetrate infected cysts. Here, we report the case of a 43-year-old Japanese man with disseminated urogenital tuberculosis (TB) and ADPKD without human immunodeficiency virus (HIV) infection. Delayed diagnosis and ineffective anti-TB chemotherapy worsened his condition. Finally, he underwent bilateral nephrectomy but experienced postoperative complications. In conclusion, kidney TB should be recognized as a cause of renal infection in ADPKD, and surgical treatment should be instituted without delay. The importance of early diagnosis and treatment cannot be overemphasized to prevent kidney TB deterioration.
authors.affiliation: Department of Urology, Saitama Red Cross Hospital, Saitama, Japan. take_uro@ybb.ne.jp
authors.forename: Hideki
authors.initials: H
authors.lastname: Takeshita
authors.forename: Morimasa
authors.initials: M
authors.lastname: Amemiya
authors.forename: Koji
authors.initials: K
authors.lastname: Chiba
authors.forename: Masayasu
authors.initials: M
authors.lastname: Urushibara
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Satoh
authors.forename: Akira
authors.initials: A
authors.lastname: Noro
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use; D001431:Bacteriological Techniques; D057210:Delayed Diagnosis; D006801:Humans; D008297:Male; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification*; D009392:Nephrectomy; D009919:Orchiectomy; D016891:Polycystic Kidney, Autosomal Dominant / Q000150:complications*; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D014389:Tuberculosis, Male Genital / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D014391:Tuberculosis, Miliary / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D014398:Tuberculosis, Renal / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy
chemical_list: D000995:Antitubercular Agents