title: [Evaluation of effects of gamma-irradiation at low doses on repair and meiotic recombination mutants of Drosophila melanogaster].
abstract: A comparative study of the effects of gene mutations mus209, mus309, mei-41 and rad54 of Drosophila melanogaster on the sensitivity to low-level exposure of different duration was carried out. Taken into account was the survival rate at different stages of ontogeny, female fecundity, the frequency of dominant lethal mutations (DLM) and the DNA damage. mei-41 and rad-54 mutants were most sensitive to the action of low dose radiation (80 mGy) in terms of survival and DLM. However, at the level of DNA damage, an increased radiosensitivity is observed only at larger doses of low intensity irradiation. Based on these observations, we can conclude about the importance of repair and its genes in the formation of the effect of low level doses of ionizing radiation in Drosophila.
authors.forename: E A
authors.initials: EA
authors.lastname: Iushkova
authors.forename: V G
authors.initials: VG
authors.lastname: Zaĭnullin
authors.forename: O A
authors.initials: OA
authors.lastname: Startseva
mesh_terms: D000818:Animals; D018797:Cell Cycle Proteins / Q000235:genetics; D004249:DNA Damage; D004265:DNA Helicases / Q000235:genetics; D004260:DNA Repair / Q000235:genetics / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D029721:Drosophila Proteins / Q000235:genetics; D004331:Drosophila melanogaster / Q000235:genetics* / Q000528:radiation effects*; D005260:Female; D005720:Gamma Rays; D005804:Genes, Lethal / Q000528:radiation effects; D008540:Meiosis / Q000528:radiation effects*; D009154:Mutation; D017346:Protein Serine-Threonine Kinases / Q000235:genetics; D011836:Radiation Tolerance / Q000235:genetics*; D053484:RecQ Helicases / Q000235:genetics; D011995:Recombination, Genetic / Q000528:radiation effects*
chemical_list: D018797:Cell Cycle Proteins; D029721:Drosophila Proteins; C444435:Mei-41 protein, Drosophila; D017346:Protein Serine-Threonine Kinases; C097151:Bloom syndrome protein; C108443:okr protein, Drosophila; D004265:DNA Helicases; D053484:RecQ Helicases