title: Phencyclidine/schizophrenia: one view toward the past, the other to the future.
abstract: The history of the chemical synthesis and animal/human pharmacology of phencyclidine is documented. From its early use as a general anesthetic, chemical model of schizophrenia, and drug of abuse, phencyclidine has had a checkered history. Research with this agent and its chemical derivatives like ketamine have provided a solid foundation for just a beginning to understanding the neuropathology of schizophrenia.
authors.affiliation: Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109-5632, USA. efdabcde@umich.edu
authors.forename: Edward F
authors.initials: EF
authors.lastname: Domino
authors.forename: Elliot D
authors.initials: ED
authors.lastname: Luby
mesh_terms: D000777:Anesthetics / Q000266:history*; D000818:Animals; D004195:Disease Models, Animal; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D013287:Illicit Drugs / Q000266:history*; D009480:Neuropharmacology / Q000266:history*; D010622:Phencyclidine / Q000266:history*; D011605:Psychoses, Substance-Induced / Q000266:history*; D012559:Schizophrenia / Q000266:history*
chemical_list: D000777:Anesthetics; D013287:Illicit Drugs; D010622:Phencyclidine