title: Post-mortem evaluation of expanded polytetrafluoroethylene (ePTFE) used in mitral valve repair in dogs.
abstract: Mitral valve repair is one of the treatment options for mitral regurgitation. Expanded polytetrafluoroethylene (ePTFE) is a polymer that has been widely used in cardiovascular surgery. In this case series, we report the autopsy and histological findings in 6 dogs that underwent cardiopulmonary bypass for mitral annuloplasty using ePTFE sheets and chordoplasty using ePTFE sutures. From May 2005 to October 2009, 3 female and 3 male dogs with severe mitral regurgitation underwent mitral valve repair. This case series included 3 Cavalier King Charles spaniels, 2 Maltese, and 1 Shih Tzu. The survival period after surgery was 19-72 (35 ± 19) months. In all the cases, autopsy revealed that the ePTFE sheets and sutures were not damaged and well integrated into the surrounding highly differentiated, connective tissues. Low-power microscopy revealed that in all cases, the tissues surrounding the ePTFE sheet in the mitral valve annulus had almost completely been covered by granulation tissue. No inflammatory infiltrate or thrombogenesis was observed around the ePTFE in any of the cases. There was no evidence of reactive changes in the region surrounding the ePTFE. These results suggest that ePTFE has excellent tissue compatibility and durability and can be effectively used for canine mitral valve repair.
authors.affiliation: Veterinary Cardiovascular Medicine and Surgery, Laboratory of Veterinary Internal Medicine, Department of Veterinary Medicine, College of Bioresource Science, Nihon University, Japan.
authors.forename: Miki
authors.initials: M
authors.lastname: Nishida
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Kagawa
authors.forename: Takahiro
authors.initials: T
authors.lastname: Mizukoshi
authors.forename: Masashi
authors.initials: M
authors.lastname: Mizuno
authors.forename: Takeshi
authors.initials: T
authors.lastname: Mizuno
authors.forename: Kayoko
authors.initials: K
authors.lastname: Harada
authors.forename: Masami
authors.initials: M
authors.lastname: Uechi
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000601:surgery*; D004285:Dogs; D005260:Female; D006350:Heart Valve Prosthesis / Q000662:veterinary*; D008297:Male; D008944:Mitral Valve Insufficiency / Q000601:surgery / Q000662:veterinary*; D011138:Polytetrafluoroethylene
chemical_list: D011138:Polytetrafluoroethylene