title: Evaluation of Antihyperglycemic Activity of Citrus limetta Fruit Peel in Streptozotocin-Induced Diabetic Rats.
abstract: The present paper aims to evaluate antihyperglycemic activity of methanol extract of Citrus limetta fruit peel (MECL) in streptozotocin-induced (STZ; 65 mg/kg b.w.) diabetic rats. Three days after STZ induction, diabetic rats received MECL orally at 200 and 400 mg kg(-1) body weight daily for 15 days. Glibenclamide (0.5 mg kg(-1) p. o.) was used as reference drug. Blood glucose levels were measured on 0th, 4th, 8th, and 15th days of study. Serum biochemical parameters namely, SGOT, SGPT and ALP were estimated. The TBARS and GSH levels of pancreas, kidney, and liver were determined. MECL significantly (P < 0.001) and dose dependently normalized blood glucose levels and serum biochemical parameters, decreased lipid peroxidation, and recovered GSH as compared to those of STZ control. The present paper infers that in STZ-induced diabetic Wistar rats, C. limetta fruit peel demonstrated a potential antihyperglycemic effect which may be attributed to its antioxidant property.
authors.affiliation: Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal 700032, India.
authors.forename: Sriparna
authors.initials: S
authors.lastname: Kundusen
authors.forename: Pallab K
authors.initials: PK
authors.lastname: Haldar
authors.forename: Malaya
authors.initials: M
authors.lastname: Gupta
authors.forename: Upal K
authors.initials: UK
authors.lastname: Mazumder
authors.forename: Prerona
authors.initials: P
authors.lastname: Saha
authors.forename: Asis
authors.initials: A
authors.lastname: Bala
authors.forename: Sanjib
authors.initials: S
authors.lastname: Bhattacharya
authors.forename: Biswakanth
authors.initials: B
authors.lastname: Kar