title: [Clinical trials and intensive therapy of the swine flu (H1N1)].
abstract: During the recent years there's a high index of the swine flu А (H1N1) disease in the whole world. In Georgia it began to spread at the end of Autumn 2009. The aim of our study was to define clinical trials of the swine flu (H1N1) in patients of Republic Clinical Hospital in Batumi from 2009 to 2011 and to generalize the methods of treatment. In the hospital there were 94 patients suffering from the swine flu (H1N1) disease, 20 of which due to their critical situation of the disease were treated in the department of the intensive therapy. We studied case histories of 20 patients, who were undergoing treatment in the department of the intensive therapy by the generally acknowledged programme of study and monitoring due to their hard disease. Among these 20 patients 10 were women and 10 men. 10 patients died. The programme of intensive treatment consisted of infusive-transfusive therapy by the negative water balance, antivirus treatment (Tamiflu/Relenza), de-escalation antibiotic therapy, mechanic ventilation of lungs, aerosol therapy, plus symptom treatment. In 2011 there were fewer cases of the swine flu and the death rate compared to the earlier years. In 2011 of 25 patients only one patient died, but in 2009-2010 of 69 patients 7 patients died), which was conditioned by immunity development. The most frequently used regime of lung mechanic ventilation was BIPAR. In the first days antibiotic therapy is not defining. It is necessary to find more effective method of antivirus treatment.
authors.forename: I M
authors.initials: IM
authors.lastname: Nakashidze
authors.forename: N G
authors.initials: NG
authors.lastname: Tsintsadze
authors.forename: Sh N
authors.initials: ShN
authors.lastname: Potskhishvili
authors.forename: K M
authors.initials: KM
authors.lastname: Dzhibladze
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D000368:Aged; D001663:Bilirubin / Q000097:blood; D004196:Disease Outbreaks; D005260:Female; D005846:Georgia (Republic) / Q000453:epidemiology; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000302:isolation & purification; D007251:Influenza, Human / Q000097:blood / Q000453:epidemiology* / Q000401:mortality / Q000628:therapy*; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D053139:Oseltamivir / Q000627:therapeutic use; D053243:Zanamivir / Q000627:therapeutic use
chemical_list: D053139:Oseltamivir; D053243:Zanamivir; D001663:Bilirubin