title: Synthesis, resolution, and absolute configuration of chiral 4,4'-bipyridines.
abstract: A chiral polyhalogenated 4,4'-bipyridine derivative is described allowing an easy access to a new family of chiral 4,4'-bipyridines by site-selective cross-coupling reactions. The absolute configurations of all the HPLC separated enantiomers were determined by X-ray diffraction and electronic circular dichroism coupled with time-dependent density functional theory calculations.
authors.affiliation: Laboratoire SRSMC UMR CNRS 7565, Nancy Université, 54506 Vandoeuvre-les-Nancy, France. victor.mamane@srsmc.uhp-nancy.fr
authors.forename: Victor
authors.initials: V
authors.lastname: Mamane
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Aubert
authors.forename: Paola
authors.initials: P
authors.lastname: Peluso
authors.forename: Sergio
authors.initials: S
authors.lastname: Cossu
mesh_terms: D002851:Chromatography, High Pressure Liquid; D006846:Hydrocarbons, Halogenated / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism; D014961:X-Ray Diffraction
chemical_list: D006846:Hydrocarbons, Halogenated; D011725:Pyridines; C034306:4,4'-bipyridyl