title: Effect of the surfactant on the availability of piroxicam as a poorly hydrosoluble drug from suppositories.
abstract: The use of surfactants in suppository formulations has been suggested to improve availability of poorly soluble drugs. In the present study, different kinds of surfactants have been investigated to clarify the influence on piroxicam release from suppositories formulated with both lipophilic and hydrophilic bases. Two hydrophilic glucose-derivate surfactants, and a polyoxylglyceride amphiphilic surfactant, all with high HLB values, were investigated for their use in improving drug availability. The two glucose derivate surfactants reduced drug availability from both lipophilic suppositories and hydrophilic formulations, according to longer disintegration times and drug micellization. The more complex surfactant, a lauroyl macrogolglyceride, showed an increase in piroxicam availability from lipophilic suppositories at the higher tested concentrations (15% and 20%). Otherwise, when used in hydrophilic formulations, it was less effective in promoting drug release and even reduced drug availability.
authors.affiliation: Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Padova, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Dal Zorro
authors.forename: E
authors.initials: E
authors.lastname: Franceschinis
authors.forename: A
authors.initials: A
authors.lastname: Punchina
authors.forename: N
authors.initials: N
authors.lastname: Realdon
mesh_terms: D000042:Absorption; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics*; D001682:Biological Availability; D005079:Excipients; D057927:Hydrophobic and Hydrophilic Interactions; D007413:Intestinal Mucosa / Q000378:metabolism; D008567:Membranes, Artificial; D010316:Particle Size; D010894:Piroxicam / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics*; D011092:Polyethylene Glycols; D012007:Rectum / Q000378:metabolism; D012212:Rheology; D012995:Solubility; D013488:Suppositories; D013501:Surface-Active Agents / Q000737:chemistry*; D014280:Triglycerides
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005079:Excipients; D008567:Membranes, Artificial; D013488:Suppositories; D013501:Surface-Active Agents; D014280:Triglycerides; C009683:witepsol; D010894:Piroxicam; D011092:Polyethylene Glycols