title: Aryl ether as a Negishi coupling partner: an approach for constructing C-C bonds under mild conditions.
abstract: An etheric Negishi coupling: The first cross-coupling reaction between aryl alkyl ethers and dianion-type zincate reagents to afford biaryl compounds through selective cleavage of the etheric C(sp(2))-O bond was developed. Dianion-type zincates showed excellent reactivity toward the aromatic ethers under mild conditions, with good functional group compatibility (see scheme).
authors.affiliation: Advanced Elements Chemistry Research Team, Advanced Science Institute, RIKEN, 2-1 Hirosawa, Wako-shi, Saitama, 351-0198, Japan. chaowang@riken.jp
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.forename: Takashi
authors.initials: T
authors.lastname: Ozaki
authors.forename: Ryo
authors.initials: R
authors.lastname: Takita
authors.forename: Masanobu
authors.initials: M
authors.lastname: Uchiyama