title: [Experiment of praziquantel rectal administration in treatment of schistosomiasis in mice].
abstract: OBJECTIVE
  To evaluate the efficiency of rectal administration of praziquantel in the treatment of schistosomiasis in mice.
  
  
  METHODS
  Forty mice were divided into 4 groups. Each mouse was infected with Schistosoma japonicum cercariae 40 +/- 2. Forty-two days after the infection, the mouse was rectally administered with different doses of praziquantel. In the first, second and third group, each mouse was given 100, 200 mg/kg, and 400 mg/kg single dose of praziquantel, and the fourth group was a blank control group. One week after the administration, all the mice were sacrificed and the worm reduction rate, reduction rate of liver eggs, and matching reduction rate were calculated. RESULTS The worm reduction rate and matching reduction rate were 57.63% and 76.60% respectively in the 200 mg/kg group, and 49.15% and 51.06% respectively in the 400 mg/kg group, which were better than those in the 100 mg/kg group.
  
  
  CONCLUSIONS
  Rectal administration of praziquantel has good efficiency in the treatment of schistosomiasis in mice; therefore, it provides a new option for the prevention and control of animal schistosomiasis.
authors.affiliation: Veterinary Medicine College, Shenyang Agricultural University, Shenyang 110866, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Yang
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Jiang
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Li
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.forename: Chuan-Gang
authors.initials: CG
authors.lastname: Zhu
authors.forename: Yao-Jun
authors.initials: YJ
authors.lastname: Shi
mesh_terms: D000285:Administration, Rectal; D000818:Animals; D058487:Cercaria / Q000187:drug effects / Q000254:growth & development; D006801:Humans; D008297:Male; D051379:Mice; D011223:Praziquantel / Q000008:administration & dosage*; D012549:Schistosoma japonicum / Q000187:drug effects* / Q000254:growth & development; D012554:Schistosomiasis japonica / Q000188:drug therapy* / Q000469:parasitology; D012556:Schistosomicides / Q000008:administration & dosage*
chemical_list: D012556:Schistosomicides; D011223:Praziquantel