title: Chemical and bioactive diversities of the genus Chaetomium secondary metabolites.
abstract: The genus Chaetomium fungi are considered to be a rich source of novel and bioactive secondary metabolites of great importance. Up till now, a variety of more than 200 secondary metabolites belonging to diverse structural types of chaetoglobosins, epipolythiodioxopiperazines, azaphilones, xanthones, anthraquinones, chromones, depsidones, terpenoids, and steroids have been discovered. Most of these fungal metabolites exhibited antitumor, cytotoxic, antimalarial, enzyme inhibitory, antibiotic, and other activities. This review covers the extraction, structure elucidation, structural diversity, and biological activities of natural products isolated from about 30 fungi associated with marine- and terrestrial- origins, and highlights some bioactive compounds as well as their mechanisms of action and structure-activity relationships.
authors.affiliation: Shaaxi Engineering Center of Bioresource Chemistry & Sustainable Utilization, College of Science, Northwest A & F University, Yangling, Shaanxi 712100, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Zhang
authors.forename: H-Q
authors.initials: HQ
authors.lastname: Li
authors.forename: S-C
authors.initials: SC
authors.lastname: Zong
authors.forename: J-M
authors.initials: JM
authors.lastname: Gao
authors.forename: A-L
authors.initials: AL
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001688:Biological Products / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D049109:Cell Proliferation / Q000187:drug effects; D002597:Chaetomium / Q000737:chemistry* / Q000378:metabolism*; D005658:Fungi / Q000187:drug effects; D006801:Humans
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D001688:Biological Products