title: Investigating the copper coordination, electrochemistry, and Cu(II) reduction kinetics of biologically relevant selone and thione compounds.
abstract: Selenium- and sulfur-containing compounds can act as antioxidants by binding copper. To determine how this copper coordination results in the observed antioxidant activity, biologically relevant Cu(+) and Cu(2+) complexes with the formulae [Cu(dmit)(3)](+) (3), [Cu(dmise)(4)](+) (4a), and [Tpm(iPr)Cu(MISeox)](2+) (6) (dmise = N,N'-dimethylimidazole selone; dmit = N,N'-dimethylimidazole thione; MISeox = bis(1-methylimidazolyl)diselenide; Tpm(iPr) = tris(1,3-diisopropylpyrazolyl)methane) were synthesized, characterized, and their structures determined by single-crystal X-ray crystallography. In addition, kinetic studies using UV-vis spectroscopy indicate that dmise reduces Cu(2+) to Cu(+) three times faster than dmit. Coordination of dmise and MISeox to copper also results in more negative Cu(2+/+) reduction potentials (-373 mV and -503 mV) compared to dmit (-217 mV). These results highlight the different complexation behaviors and reactivities of analogous selone- and thione-containing compounds, traits which likely influence their antioxidant activity.
authors.affiliation: Department of Chemistry, Clemson University, Clemson, SC 29634-0973, USA.
authors.forename: Martin M
authors.initials: MM
authors.lastname: Kimani
authors.forename: Hsiao C
authors.initials: HC
authors.lastname: Wang
authors.forename: Julia L
authors.initials: JL
authors.lastname: Brumaghim
mesh_terms: D000975:Antioxidants / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D004563:Electrochemistry; D007700:Kinetics; D009942:Organometallic Compounds / Q000737:chemistry*; D010084:Oxidation-Reduction; D012643:Selenium / Q000737:chemistry*; D013455:Sulfur / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D009942:Organometallic Compounds; D013455:Sulfur; D003300:Copper; D012643:Selenium