title: Synthesis of fused indazole ring systems and application to nigeglanine hydrobromide.
abstract: The single-step synthesis of fused tricyclic pyridazino[1,2-a]indazolium ring systems is described. Structural details revealed by crystallography explain the unexpected reactivity. The method is applied to the gram scale synthesis of nigeglanine hydrobromide.
authors.affiliation: The Scripps Research Institute Mail MB-26, 10550 North Torrey Pines Road, La Jolla, California 92037, United States.
authors.forename: Aaron C
authors.initials: AC
authors.lastname: Sather
authors.forename: Orion B
authors.initials: OB
authors.lastname: Berryman
authors.forename: Julius
authors.initials: J
authors.lastname: Rebek
mesh_terms: D002384:Catalysis; D018360:Crystallography, X-Ray; D006575:Heterocyclic Compounds, 3-Ring / Q000138:chemical synthesis* / Q000737:chemistry; D007191:Indazoles / Q000138:chemical synthesis* / Q000737:chemistry; D008968:Molecular Conformation; D015394:Molecular Structure
chemical_list: D006575:Heterocyclic Compounds, 3-Ring; D007191:Indazoles; C493028:nigeglanine