title: [Comparative study on pharmacokinetics of six major alkaloids in Zuojin Wan microemulsion based gel and hydrogel].
abstract: OBJECTIVE
  To compare the pharmcoknetic parameters of six major alkaloids in the two drug delivery system of Zuojin Wan, by LC-MS assaying the six major alkaloids plasma concentration.
  
  
  METHODS
  The blood samples were collected at different time after transdermal administration. The plasma concentration of six major alkaloids were detected by LC-MS, then the concentration-time data are modulated by software WinNonlin.
  
  
  RESULTS
  Took the six alkaloids (berberine palmatine coptisine jateorhizine evodiamine rutecarpine) as index components, the relative bioavailability were 131%, 127%, 108%, 121%, 92%, 109%, respectively, the ratio of Ka were 10.5, 5.1, 3.7, 0.8, 1.8, 1.5, respectively.
  
  
  CONCLUSIONS
  The LC-MS can be applied in the determination of six major alkaloids plasma concentration. The pharmcoknetic parameters indicated that Zuojin Wan microemulsion gel delivery system can accelerate the transdermal absorption rate of Zuojin Wan, compared with the hydrogel drug delivery system.
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
authors.forename: Long
authors.initials: L
authors.lastname: Cheng
authors.forename: Yanli
authors.initials: Y
authors.lastname: Wang
authors.forename: Shuzhi
authors.initials: S
authors.lastname: Liu
authors.forename: Lan
authors.initials: L
authors.lastname: Wang
authors.forename: Hong
authors.initials: H
authors.lastname: Yi
authors.forename: Maobo
authors.initials: M
authors.lastname: Du
authors.forename: Hua
authors.initials: H
authors.lastname: Yang
authors.forename: Rixin
authors.initials: R
authors.lastname: Liang
authors.forename: Xiaojie
authors.initials: X
authors.lastname: Yin
mesh_terms: D000470:Alkaloids / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics*; D000818:Animals; D002853:Chromatography, Liquid; D016503:Drug Delivery Systems; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics*; D004655:Emulsions; D005260:Female; D005782:Gels; D020100:Hydrogels / Q000737:chemistry; D008297:Male; D013058:Mass Spectrometry; D051381:Rats
chemical_list: D000470:Alkaloids; D004365:Drugs, Chinese Herbal; D004655:Emulsions; D005782:Gels; D020100:Hydrogels