title: c-Kit proto-oncogene expression in endometrial hyperplasia and endometrial cancer.
abstract: OBJECTIVE
  To evaluate the expression of c-kit (CD117) in endometrial hyperplasia and endometrial cancer.
  
  
  METHODS
  Expression of c-kit in 10 normal endometrium, 18 simple endometrial hyperplasia, 16 complex endometrial hyperplasia (10 cases with atypia and 6 cases without atypia), and 6 endometrial cancer were investigated by immunohistochemistry.
  
  
  RESULTS
  c-Kit expression decreased as the lesion progressed to endometrial cancer. Immunostaining was mostly focal and weak in the normal endometrium and was mostly diffuse and strong in the simple and complex endometrial hyperplasia.
  
  
  CONCLUSIONS
  Simple and complex hyperplastic endometrial tissues express diffuse cytoplasmic staining for c-kit and the expression decreases with the progression of the lesion.
authors.affiliation: Department of Obstetrics and Gynecology, Inonu University School of Medicine, Malatya, Turkey. ercanyilmazgyn@yahoo.com
authors.forename: Ercan
authors.initials: E
authors.lastname: Yilmaz
authors.forename: Onder
authors.initials: O
authors.lastname: Celik
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Simsek
authors.forename: Ilgin
authors.initials: I
authors.lastname: Turkcuoglu
authors.forename: Ebru
authors.initials: E
authors.lastname: Celik
authors.forename: Mehmet
authors.initials: M
authors.lastname: Gül
authors.forename: Seyma
authors.initials: S
authors.lastname: Hascalik
authors.forename: Nasuhi Engin
authors.initials: NE
authors.lastname: Aydin
authors.forename: Engin
authors.initials: E
authors.lastname: Aydin
mesh_terms: D000704:Analysis of Variance; D002471:Cell Transformation, Neoplastic / Q000378:metabolism; D016889:Endometrial Neoplasms / Q000378:metabolism*; D004717:Endometrium / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D006801:Humans; D006965:Hyperplasia / Q000378:metabolism; D007150:Immunohistochemistry; D000090063:Proto-Oncogene Mas; D019009:Proto-Oncogene Proteins c-kit / Q000378:metabolism*
chemical_list: C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D019009:Proto-Oncogene Proteins c-kit