title: Association of baseline urodynamic measures of urethral function with clinical, demographic, and other urodynamic variables in women prior to undergoing midurethral sling surgery.
abstract: OBJECTIVE
  To explore how baseline demographic, clinical, and urodynamic (UDS) variables correlate with measures of urethral function in women planning midurethral sling surgery.
  
  
  METHODS
  Women with predominant stress urinary incontinence (SUI) as part of the trial of mid-urethral slings (TOMUS) were characterized preoperatively including: demographics, body mass index (BMI), responses to the Medical and Epidemiologic Social Aspects of Aging (MESA) and Urogenital Distress Inventory (UDI) questionnaires, pad weight (PW), incontinence duration, prior SUI surgery, prolapse, strength of pelvic contraction, Q-tip test, uroflow, cystometrogram, and detrusor pressures at maximum flow (Pdet at Qmax). Multivariate regression analysis and modeling confirmed variables with significant correlations with maximal urethral closure pressure (MUCP), functional urethral length (FUL), and Valsalva leak point pressure (VLPP).
  
  
  RESULTS
  Five-hundred thirty-nine women were included in the analysis. In multivariable analyses, PW (P =  0.045) and age (P < 0.0001) were negatively correlated with MUCP (as PW and age increased, MUCP decreased); BMI (P = 0.02) and Pdet at Qmax (P < 0.0001) were positively correlated with MUCP (as BMI and Pdet at Qmax increased, MUCP increased). Age (P = 0.002) was negatively correlated with FUL; Qtip delta (P = 0.006), pelvic organ prolapse quantification examination (POPQ) stage (P = 0.002) and strength of pelvic contraction (P = 0.03) were positively correlated with FUL. Duration of incontinence (P = 0.01) was negatively correlated with VLPP; Qtip delta (P = 0.02), BMI (P = 0.0005) and Pdet at Qmax (P = 0.0005) were positively correlated with VLPP.
  
  
  CONCLUSIONS
  Age, BMI, Qtip delta, and Pdet at Qmax were variables that correlated with two or more measures of urethral function. These correlations may help direct future research in female urethral function.
authors.affiliation: University of Maryland School of Medicine, Baltimore, MD, USA. tchai@smail.umaryland.edu
authors.forename: Toby C
authors.initials: TC
authors.lastname: Chai
authors.forename: Liyuan
authors.initials: L
authors.lastname: Huang
authors.forename: Kim
authors.initials: K
authors.lastname: Kenton
authors.forename: Holly E
authors.initials: HE
authors.lastname: Richter
authors.forename: Jan
authors.initials: J
authors.lastname: Baker
authors.forename: Stephen
authors.initials: S
authors.lastname: Kraus
authors.forename: Heather
authors.initials: H
authors.lastname: Litman
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008875:Middle Aged; D053825:Suburethral Slings; D014521:Urethra / Q000503:physiopathology / Q000601:surgery*; D001743:Urinary Bladder / Q000503:physiopathology / Q000601:surgery*; D014550:Urinary Incontinence, Stress / Q000503:physiopathology / Q000601:surgery*; D014563:Urodynamics / Q000502:physiology*