title: Case report: atypical lipomatous tumor with unusual extensive metaplastic ossification.
abstract: The presence of metaplastic ossification within atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDLPS) is a rare occurrence. When present, bone formation is most often found in association with a dedifferentiated component arising within the primary tumor. It is important for the radiologist not only to recognize the differential diagnosis of a calcified or ossified soft tissue mass but also be aware of the various soft tissue neoplasms, both aggressive and non-aggressive, that may show such features. We report a case of ALT/WDLPS with unusual extensive metaplastic bone formation without an element of dedifferentiated liposarcoma.
authors.affiliation: aDepartment of Radiology, Brigham and Womens Hospital, Harvard Medical School, Boston, MA 02215, USA.
authors.forename: Omar
authors.initials: O
authors.lastname: Javery
authors.forename: Jyothi P
authors.initials: JP
authors.lastname: Jagannathan
authors.forename: Sachin S
authors.initials: SS
authors.lastname: Saboo
authors.forename: Kevin
authors.initials: K
authors.lastname: O'Regan
authors.forename: Jason L
authors.initials: JL
authors.lastname: Hornick
authors.forename: Nikhil
authors.initials: N
authors.lastname: Ramaiya
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001707:Biopsy, Needle; D051358:Cyclin-Dependent Kinase 4 / Q000032:analysis; D003937:Diagnosis, Differential; D006801:Humans; D008080:Liposarcoma / Q000737:chemistry / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D008679:Metaplasia; D009999:Ossification, Heterotopic / Q000000981:diagnostic imaging* / Q000209:etiology / Q000473:pathology; D049268:Positron-Emission Tomography; D051736:Proto-Oncogene Proteins c-mdm2 / Q000032:analysis; D015641:Radiography, Interventional; D019275:Radiopharmaceuticals; D012782:Shoulder; D012983:Soft Tissue Neoplasms / Q000737:chemistry / Q000150:complications / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D013669:Technetium Tc 99m Medronate; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor; D019275:Radiopharmaceuticals; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2; C495900:CDK4 protein, human; D051358:Cyclin-Dependent Kinase 4; D013669:Technetium Tc 99m Medronate