title: In vivo antioxidant activities of essential oils and their constituents from leaves of the Taiwanese Cinnamomum osmophloeum.
abstract: Cinnamomum osmophloeum Kaneh is an indigenous tree species in Taiwan. In this study, phytochemical characteristics and antioxidant activities of the essential oils and key constituents from the leaves of two C. osmophloeum clones were investigated. The two trees possess two chemotypes, which were classified as the cinnamaldehyde type and camphor type. We demonstrated that the essential oils from C. osmophloeum leaves exerted in vivo antioxidant activities in Caenorhabditis elegans. In addition, trans-cinnamaldehyde and D-(+)-camphor, which respectively represent the major compounds in the cinnamaldehyde-type and camphor-type trees, exerted significant in vivo antioxidant activities against juglone-induced oxidative stress in C. elegans. Moreover, expressions of antioxidative-related genes, including superoxide dismutase (SOD) and glutathione S-transferase (GST), were significantly induced by trans-cinnamaldehyde and D-(+)-camphor from C. osmophloeum leaves. Our results showed that the essential oils from C. osmophloeum leaves and their major compounds might have good potential for further development as nutraceuticals or antioxidant remedies.
authors.affiliation: Department of Bioenvironmental Systems Engineering, National Taiwan University, Number 1, Section 4, Roosevelt Road, Taipei 106, Taiwan.
authors.forename: Fu-Lan
authors.initials: FL
authors.lastname: Hsu
authors.forename: Wen-Hsuan
authors.initials: WH
authors.lastname: Li
authors.forename: Chan-Wei
authors.initials: CW
authors.lastname: Yu
authors.forename: Yi-Chen
authors.initials: YC
authors.lastname: Hsieh
authors.forename: Ying-Fei
authors.initials: YF
authors.lastname: Yang
authors.forename: Jui-Tung
authors.initials: JT
authors.lastname: Liu
authors.forename: Justin
authors.initials: J
authors.lastname: Shih
authors.forename: Yu-Ju
authors.initials: YJ
authors.lastname: Chu
authors.forename: Pei-Ling
authors.initials: PL
authors.lastname: Yen
authors.forename: Shang-Tzen
authors.initials: ST
authors.lastname: Chang
authors.forename: Vivian Hsiu-Chuan
authors.initials: VH
authors.lastname: Liao
mesh_terms: D000171:Acrolein / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D017173:Caenorhabditis elegans / Q000187:drug effects; D002164:Camphor / Q000494:pharmacology; D027424:Cinnamomum / Q000737:chemistry*; D015870:Gene Expression / Q000187:drug effects; D005982:Glutathione Transferase / Q000235:genetics; D009285:Naphthoquinones / Q000494:pharmacology; D009822:Oils, Volatile / Q000737:chemistry / Q000494:pharmacology*; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000187:drug effects; D018515:Plant Leaves / Q000737:chemistry*; D013482:Superoxide Dismutase / Q000235:genetics; D013624:Taiwan
chemical_list: D000975:Antioxidants; D009285:Naphthoquinones; D009822:Oils, Volatile; D002164:Camphor; D000171:Acrolein; D013482:Superoxide Dismutase; D005982:Glutathione Transferase; C012843:cinnamaldehyde; C005134:juglone