title: Evaluation of the Sexual Desire Relationship Distress Scale (SDRDS) in women with hypoactive sexual desire disorder.
abstract: BACKGROUND
  The Sexual Desire Relationship Distress Scale (SDRDS) was developed to address the need for a patient-reported outcome (PRO) measure of sexual distress associated with hypoactive sexual desire disorder (HSDD). The SDRDS is a 17-item PRO that includes items related to personal distress and distress related to relationship with partner.
  
  
  OBJECTIVE
  The aim of this article was to evaluate the psychometric properties of the SDRDS among women with HSDD.
  
  
  METHODS
  Pre- and post-menopausal women with HSDD or with no sexual dysfunction completed the SDRDS, Sexual Activity Questions, Female Sexual Distress Scale-Revised (FSDS-R), and desire domain of the Female Sexual Function Index (FSFI) at baseline and 2 and 4 weeks later.
  
  
  METHODS
  The main outcome measures of this article were item performance, internal consistency, test-retest reliability, construct validity, known groups validity, and responsiveness of the SDRDS.
  
  
  RESULTS
  Data from 260 women were analyzed: 101 in each of the pre- and post-menopausal HSDD groups and 29 in each of the pre- and post-menopausal control groups. No differences emerged between pre- and post-menopausal women. Least-squares mean (±standard errors [SE]) SDRDS score was higher in women with HSDD than in women with no sexual dysfunction (43.1 ± 0.9 vs. 6.1 ± 1.7; P < 0.0001), supporting known groups validity. Individual item scores correlated with total scores (r = 0.7-0.9; P < 0.0001). Internal consistency was high, with a Cronbach's alpha of 0.973 at baseline. Test-retest reliability was good, with an intraclass correlation coefficient of 0.89. SDRDS scores correlated strongly with other measures of sexual distress and sexual function including the FSDS-R and FSFI desire domain items. Preliminary analyses suggested that the SDRDS was sensitive to changes in clinical status.
  
  
  CONCLUSIONS
  The SDRDS provides a comprehensive and reliable assessment of distress due to decreased sexual desire in women with HSDD and may be a useful measure of treatment effects in clinical trials in women with this condition.
authors.affiliation: Outcomes Research, United BioSource Corporation, Bethesda, MD 20814, USA. dennis.revicki@unitedbiosource.com
authors.forename: Dennis A
authors.initials: DA
authors.lastname: Revicki
authors.forename: Mary Kay
authors.initials: MK
authors.lastname: Margolis
authors.forename: William
authors.initials: W
authors.lastname: Fisher
authors.forename: Raymond C
authors.initials: RC
authors.lastname: Rosen
authors.forename: Miriam
authors.initials: M
authors.lastname: Kuppermann
authors.forename: Vladimir
authors.initials: V
authors.lastname: Hanes
authors.forename: Michael
authors.initials: M
authors.lastname: Sand
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007989:Libido; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011594:Psychometrics; D015203:Reproducibility of Results; D012725:Sexual Behavior / Q000523:psychology; D020018:Sexual Dysfunctions, Psychological / Q000175:diagnosis / Q000523:psychology*; D013315:Stress, Psychological / Q000175:diagnosis / Q000523:psychology