title: [Unsuccessful vitamin D treatment].
abstract: Vitamin D3 (25-OHD3) analyses have increased exponentially and vitamin D deficiency (< 25 nmol/l) is common (15% of patients). The aim of the paper is to discuss reasons for unsuccessful treatment and to question the use of ergocalciferol (vitamin D2). Lack of effect of treatment can be due to: 1) too low dose, 2) incorrect analytical methods when injection treatment (vitamin D2) is used, 3) obesity, 4) seasonal variations, and 5) poor compliance. Treatment is mandatory in order to prevent osteopenia and osteoporosis. Vitamin D3 is more potent than vitamin D2. Injections with vitamin D2 should be replaced by vitamin D3.
authors.affiliation: Klinisk Biokemisk Afdeling, Sygehus Lillebælt, Vejle, Kabbeltoft 25, 7100 Vejle, Denmark. anne.vibeke.schmedes@slb.regionsyddanmark.dk
authors.forename: Anne
authors.initials: A
authors.lastname: Schmedes
authors.forename: Henrik
authors.initials: H
authors.lastname: Hey
authors.forename: Iben
authors.initials: I
authors.lastname: Larsson
authors.forename: Morten J
authors.initials: MJ
authors.lastname: Christensen
authors.forename: Ivan
authors.initials: I
authors.lastname: Brandslund
mesh_terms: D000284:Administration, Oral; D050071:Bone Density Conservation Agents / Q000008:administration & dosage*; D002112:Calcifediol / Q000097:blood; D002762:Cholecalciferol / Q000008:administration & dosage*; D004872:Ergocalciferols / Q000008:administration & dosage*; D006801:Humans; D007273:Injections, Intramuscular; D055118:Medication Adherence; D012621:Seasons; D017211:Treatment Failure; D014808:Vitamin D Deficiency / Q000188:drug therapy*
chemical_list: D050071:Bone Density Conservation Agents; D004872:Ergocalciferols; D002762:Cholecalciferol; D002112:Calcifediol