title: Full surface embedding of gold clusters on silicon nanowires for efficient capture and photothermal therapy of circulating tumor cells.
abstract: We report on rapid thermal chemical vapor deposition growth of silicon nanowires (Si NWs) that contain a high density of gold nanoclusters (Au NCs) with a uniform coverage over the entire length of the nanowire sidewalls. The Au NC-coated Si NWs with an antibody-coated surface obtain the unique capability to capture breast cancer cells at twice the highest efficiency currently achievable (~88% at 40 min cell incubation time) from a nanostructured substrate. We also found that irradiation of breast cancer cells captured on Au NC-coated Si NWs with a near-infrared light resulted in a high mortality rate of these cancer cells, raising a fine prospect for simultaneous capture and plasmonic photothermal therapy for circulating tumor cells.
authors.affiliation: Samsung Advanced Institute of Technology, San 14-1, Nong-Seo Ri, Ki-Hung Eub, Yong-In Gun, Kyung-Ki Do 449-900, South Korea. gs8144.park@samsung.com
authors.forename: Gyeong-Su
authors.initials: GS
authors.lastname: Park
authors.forename: Hyuksang
authors.initials: H
authors.lastname: Kwon
authors.forename: Dong Wook
authors.initials: DW
authors.lastname: Kwak
authors.forename: Seong Yong
authors.initials: SY
authors.lastname: Park
authors.forename: Minseok
authors.initials: M
authors.lastname: Kim
authors.forename: Jun-Ho
authors.initials: JH
authors.lastname: Lee
authors.forename: Hyouksoo
authors.initials: H
authors.lastname: Han
authors.forename: Sung
authors.initials: S
authors.lastname: Heo
authors.forename: Xiang Shu
authors.initials: XS
authors.lastname: Li
authors.forename: Jae Hak
authors.initials: JH
authors.lastname: Lee
authors.forename: Young Hwan
authors.initials: YH
authors.lastname: Kim
authors.forename: Jeong-Gun
authors.initials: JG
authors.lastname: Lee
authors.forename: Woochul
authors.initials: W
authors.lastname: Yang
authors.forename: Hoon Young
authors.initials: HY
authors.lastname: Cho
authors.forename: Seong Keun
authors.initials: SK
authors.lastname: Kim
authors.forename: Kinam
authors.initials: K
authors.lastname: Kim
mesh_terms: D045744:Cell Line, Tumor; D006046:Gold / Q000737:chemistry* / Q000528:radiation effects; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D008027:Light; D049329:Nanostructures / Q000737:chemistry* / Q000528:radiation effects; D009374:Neoplasms, Experimental / Q000628:therapy*; D009360:Neoplastic Cells, Circulating / Q000528:radiation effects*; D010789:Phototherapy / Q000379:methods*; D012825:Silicon / Q000737:chemistry* / Q000528:radiation effects
chemical_list: D006046:Gold; D012825:Silicon