title: "Radical" model of thrombosis.
abstract: In this issue of Blood, Nishimura and colleagues present a novel in vivo murine model of thrombosis triggered on the undisrupted, activated endothelium in response to reactive oxygen species (ROS)–producing free radicals derived from oxygen (namely O(2)(-)), which can be present in the vasculature as a result of inflammation (see figure). This new in vivo model involving a novel injury, minimally invasive vessel preparation, and advanced data collection may be particularly useful in dissecting the role of inflammation in thrombosis.
authors.affiliation: Children's Hospital of Philadelphia, USA.
authors.forename: Lubica
authors.initials: L
authors.lastname: Rauova
mesh_terms: D000818:Animals; D004730:Endothelium, Vascular / Q000378:metabolism*; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism*; D008297:Male; D010974:Platelet Aggregation; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000378:metabolism*; D015398:Signal Transduction; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
chemical_list: D007375:Interleukin-1; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D014409:Tumor Necrosis Factor-alpha