title: Esterases with an introduced amidase-like hydrogen bond in the transition state have increased amidase specificity.
authors.affiliation: Department of Biochemistry, School of Biotechnology, Royal Institute of Technology (KTH), AlbaNova University Centre, 106 91 Stockholm, Sweden.
authors.forename: Per-Olof
authors.initials: PO
authors.lastname: Syrén
authors.forename: Peter
authors.initials: P
authors.lastname: Hendil-Forssell
authors.forename: Lucie
authors.initials: L
authors.lastname: Aumailley
authors.forename: Werner
authors.initials: W
authors.lastname: Besenmatter
authors.forename: Farida
authors.initials: F
authors.lastname: Gounine
authors.forename: Allan
authors.initials: A
authors.lastname: Svendsen
authors.forename: Mats
authors.initials: M
authors.lastname: Martinelle
authors.forename: Karl
authors.initials: K
authors.lastname: Hult
mesh_terms: D000577:Amides / Q000737:chemistry / Q000378:metabolism; D000581:Amidohydrolases / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D019295:Computational Biology; D004950:Esterases / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D004952:Esters / Q000737:chemistry / Q000378:metabolism; D006860:Hydrogen Bonding; D006868:Hydrolysis; D007700:Kinetics; D008958:Models, Molecular; D013379:Substrate Specificity
chemical_list: D000577:Amides; D004952:Esters; D004950:Esterases; D000581:Amidohydrolases; C019665:amidase