title: Zinc toxicity: denture adhesives, bone marrow failure and polyneuropathy.
abstract: A 36-year-old female developed bone marrow failure diagnosed as myelodysplastic syndrome (MDS) (Sidebar), followed shortly by a peripheral neuropathy and a gait disturbance. While waiting for a bone marrow transplant, she reported to us that she had seen attorney-generated, televised advertisements concerning the role of denture adhesives relating to her malady. Labs were then obtained demonstrating she had dramatic and unsuspected hypocupremia and hyperzincemia. Administration of copper and cessation of denture adhesives resulted in recovery of her hematopoietic system and partial resolution of the neurological sequela.
authors.affiliation: Department of Family Medicine, University of Tennessee Health Science Center, Memphis, TN, USA. lorencrown@aol.com
authors.forename: Loren A
authors.initials: LA
authors.lastname: Crown
authors.forename: Jeffery A
authors.initials: JA
authors.lastname: May
mesh_terms: D000328:Adult; D002908:Chronic Disease; D015897:Comorbidity; D003300:Copper / Q000008:administration & dosage; D003738:Dental Cements / Q000009:adverse effects* / Q000737:chemistry*; D005260:Female; D006801:Humans; D007669:Kidney Calculi / Q000453:epidemiology; D009190:Myelodysplastic Syndromes / Q000453:epidemiology / Q000209:etiology*; D010195:Pancreatitis / Q000453:epidemiology; D010292:Paresthesia / Q000453:epidemiology; D011115:Polyneuropathies / Q000209:etiology*; D012008:Recurrence; D015032:Zinc / Q000097:blood / Q000506:poisoning*
chemical_list: D003738:Dental Cements; D003300:Copper; D015032:Zinc