title: Examination of chemosensory functions in patients with dysosmia.
abstract: BACKGROUND
  To examine changes of chemical sensory functions in patients with dysosmia.
  
  
  METHODS
  The 272 study subjects included 98 healthy volunteers, 86 subjects with hyposmia and 88 subjects with functional anosmia. Their chemical sensory functions were examined using olfactory event-related potentials (oERPs), trigeminal event-related potentials (tERPs), T&T olfactometer and triple drop method, respectively.
  
  
  RESULTS
  The T&T results showed that the difference between patients and healthy subjects had statistical significance. The oERPs and tERPs results showed that patients with functional anosmia had N1 and P2 waves of prolonged latency and reduced amplitude when compared to healthy subjects with the difference of statistical significance. When compared to healthy subjects, patients with functional anosmia had clear hypogeusia and the difference had statistical significance. For the younger group there was significant difference between healthy subjects and patients in T&T, oERPs and tERPs results.
  
  
  CONCLUSIONS
  It is suggested by the apparently concomitant trigeminal nerve dysfunction and hypogeusia in patients with functional anosmia in this study that olfactory and nasal trigeminal function in young patients was clearly decreased. Our study suggests the possible application of oERPs, tERPs and three drops method in clinical diagnosis in Chinese populations and provides scientific evidence for treatment.
authors.affiliation: Center Lab of Beijing Tongren Hospital, Capital Medical University, Beijing, China.
authors.forename: Ling
authors.initials: L
authors.lastname: Yang
authors.forename: Yongxiang
authors.initials: Y
authors.lastname: Wei
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Di
authors.initials: D
authors.lastname: Yu
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Ren
authors.forename: Kunyan
authors.initials: K
authors.lastname: Li
authors.forename: Yichen
authors.initials: Y
authors.lastname: Guo
authors.forename: Jinfeng
authors.initials: J
authors.lastname: Zhang
mesh_terms: D016022:Case-Control Studies; D005071:Evoked Potentials; D006801:Humans; D000857:Olfaction Disorders / Q000503:physiopathology*; D012903:Smell; D013649:Taste