title: HPLC analysis of naturally occurring free D-amino acids in mammals.
abstract: D-amino acids are currently recognized as naturally occurring physiologically active substances and biomarkers in mammals. The progress of analytical technologies, mostly high resolution chromatographic or electrodriven separation methods, has significantly contributed to the advances in D-amino acid research in real biological matrices. In this review, we would like to describe the D-amino acid research, from the discovery of appreciable amounts of free D-amino acids in mammals to the current metabolomics study focusing on amino acid enantiomers. The liquid phase enantioselective analytical methods utilized for the determination of D-amino acids in mammals including human beings will be discussed.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
authors.forename: Yurika
authors.initials: Y
authors.lastname: Miyoshi
authors.forename: Reiko
authors.initials: R
authors.lastname: Koga
authors.forename: Tsubasa
authors.initials: T
authors.lastname: Oyama
authors.forename: Hai
authors.initials: H
authors.lastname: Han
authors.forename: Kyoko
authors.initials: K
authors.lastname: Ueno
authors.forename: Kei
authors.initials: K
authors.lastname: Masuyama
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Itoh
authors.forename: Kenji
authors.initials: K
authors.lastname: Hamase
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D002623:Chemistry Techniques, Analytical; D002845:Chromatography / Q000379:methods; D002849:Chromatography, Gas / Q000379:methods; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D004563:Electrochemistry / Q000379:methods; D006801:Humans; D055432:Metabolomics / Q000379:methods; D051381:Rats; D013237:Stereoisomerism
chemical_list: D000596:Amino Acids; D015415:Biomarkers