title: Dialysate purification after introduction of automated hot water disinfection system to central dialysis fluid delivery system.
abstract: Most dialysis clinics in Japan have mainly adopted the central dialysis fluid delivery system (CDDS) to provide constant treatment to many patients. Chemical disinfection is the major maintenance method of the CDDS. Our clinic introduced an automated hot water disinfection system that used the heat conduction effect to disinfect a reverse osmosis (RO) device and dialysis fluid supply equipment. Endotoxin level and the amount of viable bacteria often showed abnormal values before introduction of this system. After its introduction, weekly disinfection resulted in endotoxin levels and the amount of viable bacteria lower than measurement sensitivity. In hot water disinfection, water heated to 90°C in the RO tank flows into the dialysis fluid supply equipment. The maximum temperature inside the tank of the supply equipment is 86.3°C. (We confirmed that the temperature was maintained at 80°C or more for 10 minutes or more during the monitoring.) Dialysate purification was maintained even after introduction of the automated hot water disinfection system and the dialysate could be supplied stably by the CDDS. Therefore, this disinfection system might be very useful in terms of both cost and safety, and can be used for dialysis treatment of multiple patients.
authors.affiliation: Department of Nephrology and Blood Purification, Saitama Medical Center, Saitama Medical University, Japan. togawa@saitama-med.ac.jp
authors.forename: Tomonari
authors.initials: T
authors.lastname: Ogawa
authors.forename: Akihiko
authors.initials: A
authors.lastname: Matsuda
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Yamaguchi
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Sasaki
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kanayama
authors.forename: Tadaaki
authors.initials: T
authors.lastname: Maeda
authors.forename: Chie
authors.initials: C
authors.lastname: Noiri
authors.forename: Hajime
authors.initials: H
authors.lastname: Hasegawa
authors.forename: Osamu
authors.initials: O
authors.lastname: Matsumura
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Mitarai
mesh_terms: D004203:Disinfection / Q000295:instrumentation / Q000379:methods*; D015312:Hemodialysis Solutions; D006435:Renal Dialysis / Q000295:instrumentation* / Q000379:methods*; D018508:Water Purification / Q000295:instrumentation / Q000379:methods*
chemical_list: D015312:Hemodialysis Solutions