title: A randomized, prospective, double-blind study of the efficacy of dexpanthenol nasal spray on the postoperative treatment of patients with chronic rhinosinusitis after endoscopic sinus surgery.
abstract: OBJECTIVE
  To assess the efficacy of dexpanthenol nasal spray compared with normal saline spray in the postoperative treatment of patients with chronic rhinosinusitis (CRS) who underwent endoscopic sinus surgery (ESS).
  
  
  METHODS
  A prospective, randomized controlled study was conducted in CRS patients who underwent ESS. The enrolled patients had never been operated intranasally. These patients received either dexpanthenol or normal saline nasal spray intranasally four times a day for six weeks post-operatively.
  
  
  RESULTS
  Fifty CRS patients were recruited in the present study. Age ranged from 23 to 63 years (means 43.4 +/- 11.2 years). Forty-four percent of patients were diagnosed as CRS without nasal polyps (NP) (CRSs NP) and 56% were CRS with NP (CRSw NP). Twenty-five cases were randomly assigned to use dexpanthenol nasal spray whereas the other 25 cases used normal saline nasal spray. The preoperative severity of CRS, determined by the computerized tomography (CT) scan scoring system of Lund-McKay was 13.9 +/- 6.2 in the dexpanthenol group and 13.6 +/- 6.9 in the normal saline group, which were not statistically different (p > 0.05). The endoscopic scoring was 10.2 +/- 2 in the dexpanthenol group and 10.7 +/- 3 in the normal saline group, which were not statistically different (p > 0.05). The mucociliary transit time improvement (time difference between pre- and post-treatment by nasal spray) was 8.4 +/- 3.3 minutes in the dexpanthenol group and 1.7 +/- 1.2 minutes in the normal saline group, which were statistically different (p < 0.05).
  
  
  CONCLUSIONS
  The majority of the postoperative symptom scores and all of the endoscopic scores of the dexpanthenol group were not statistically different from those of the normal saline group. However, dexpanthenol nasal spray has superior efficacy compared with normal saline nasal spray on improvement of mucociliary clearance and nasal discharge in the postoperative care of CRS patients after ESS.
authors.affiliation: Division of Rhinology & Allergy, Department of Otorhinolaryngology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand. siptv@mahidol.ac.th
authors.forename: Pongsakorn
authors.initials: P
authors.lastname: Tantilipikorn
authors.forename: Prayuth
authors.initials: P
authors.lastname: Tunsuriyawong
authors.forename: Perapun
authors.initials: P
authors.lastname: Jareoncharsri
authors.forename: Anan
authors.initials: A
authors.lastname: Bedavanija
authors.forename: Paraya
authors.initials: P
authors.lastname: Assanasen
authors.forename: Chaweewan
authors.initials: C
authors.lastname: Bunnag
authors.forename: Choakchai
authors.initials: C
authors.lastname: Metheetrairut
mesh_terms: D000281:Administration, Intranasal; D000328:Adult; D016009:Chi-Square Distribution; D002908:Chronic Disease; D004311:Double-Blind Method; D004724:Endoscopy / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010205:Pantothenic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives*; D011446:Prospective Studies; D012220:Rhinitis / Q000601:surgery*; D012852:Sinusitis / Q000601:surgery*; D012965:Sodium Chloride / Q000008:administration & dosage; D016896:Treatment Outcome; D014803:Vitamin B Complex / Q000008:administration & dosage*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D014803:Vitamin B Complex; D010205:Pantothenic Acid; C007288:dexpanthenol; D012965:Sodium Chloride