title: Which diameter and angle rule provides optimal flow patterns in a coronary bifurcation?
abstract: The branching angle and diameter ratio in epicardial coronary artery bifurcations are two important determinants of atherogenesis. Murray's cubed diameter law and bifurcation angle have been assumed to yield optimal flows through a bifurcation. In contrast, we have recently shown a 7/3 diameter law (HK diameter model), based on minimum energy hypothesis in an entire tree structure. Here, we derive a bifurcation angle rule corresponding to the HK diameter model and critically evaluate the streamline flow through HK and Murray-type bifurcations. The bifurcations from coronary casts were found to obey the HK diameter model and angle rule much more than Murray's model. A finite element model was used to investigate flow patterns for coronary artery bifurcations of various types. The inlet velocity and pressure boundary conditions were measured by ComboWire. Y-bifurcation of Murray type decreased wall shear stress-WSS (10%-40%) and created an increased oscillatory shear index-OSI in atherosclerosis-prone regions as compared with HK-type bifurcations. The HK-type bifurcations were found to have more optimal flow patterns (i.e., higher WSS and lower OSI) than Murray-type bifurcations which have been traditionally believed to be optimized. This study has implications for changes in bifurcation angles and diameters in percutaneous coronary intervention.
authors.affiliation: Department of Biomedical Engineering, IUPUI, Indianapolis, IN 46202, USA.
authors.forename: Yunlong
authors.initials: Y
authors.lastname: Huo
authors.forename: Gérard
authors.initials: G
authors.lastname: Finet
authors.forename: Thierry
authors.initials: T
authors.lastname: Lefevre
authors.forename: Yves
authors.initials: Y
authors.lastname: Louvard
authors.forename: Issam
authors.initials: I
authors.lastname: Moussa
authors.forename: Ghassan S
authors.initials: GS
authors.lastname: Kassab
mesh_terms: D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects / Q000379:methods; D000818:Animals; D050197:Atherosclerosis / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D001696:Biomechanical Phenomena; D001783:Blood Flow Velocity / Q000502:physiology; D003198:Computer Simulation; D003331:Coronary Vessels / Q000033:anatomy & histology* / Q000502:physiology*; D005260:Female; D020342:Finite Element Analysis; D006439:Hemodynamics / Q000502:physiology; D018056:Hemorheology / Q000502:physiology; D006801:Humans; D008297:Male; D008955:Models, Cardiovascular; D015607:Stents; D034421:Sus scrofa