title: Preventive and improvement effects of exercise training and supplement intake in white adipose tissues on obesity and lifestyle-related diseases.
abstract: Recent increases in the number of obese individuals and individuals suffering from lifestyle-related diseases, such as type 2 diabetes, that accompany obesity have become a serious social problem. White adipose tissue (WAT) is more than a mere organ for storage of energy; it is also a highly active metabolic and endocrine organ that secretes physiologically active substances collectively known as adipokines, including tumor necrosis factor-α and adiponectin. Dysregulated expression of adipokines in WAT that is hypertrophied by obesity has been closely associated with the phenomenon of insulin resistance. Therefore, WAT is currently considered to be one of the tissues that promote lifestyle-related diseases. Reduction of excess WAT that results from obesity is seen as an important strategy in preventing and improving lifestyle-related diseases. This review shows that exercise training as well as intake of supplements, such as polyphenols, is one strategy for this, because this regimen can result in reduction of WAT mass, which affects the expression and secretory response of adipokines.
authors.affiliation: Department of Molecular Predictive Medicine and Sport Science, School of Medicine, Kyorin University, Shinkawa, Mitaka, Tokyo, Japan. sakutaku@ks.kyorin-u.ac.jp
authors.forename: Takuya
authors.initials: T
authors.lastname: Sakurai
authors.forename: Junetsu
authors.initials: J
authors.lastname: Ogasawara
authors.forename: Takako
authors.initials: T
authors.lastname: Kizaki
authors.forename: Yoshinaga
authors.initials: Y
authors.lastname: Ishibashi
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Sumitani
authors.forename: Kazuto
authors.initials: K
authors.lastname: Takahashi
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ishida
authors.forename: Hiromi
authors.initials: H
authors.lastname: Miyazaki
authors.forename: Daizoh
authors.initials: D
authors.lastname: Saitoh
authors.forename: Shukoh
authors.initials: S
authors.lastname: Haga
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Izawa
authors.forename: Hideki
authors.initials: H
authors.lastname: Ohno
mesh_terms: D052242:Adiponectin / Q000378:metabolism*; D052436:Adipose Tissue, White / Q000187:drug effects / Q000276:immunology / Q000378:metabolism*; D018932:Chemokine CCL2 / Q000378:metabolism; D019587:Dietary Supplements; D015444:Exercise; D006801:Humans; D008019:Life Style; D009765:Obesity / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control* / Q000628:therapy; D059808:Polyphenols / Q000008:administration & dosage; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D018932:Chemokine CCL2; D059808:Polyphenols; D014409:Tumor Necrosis Factor-alpha