title: Glaucoma diagnostic accuracy of ganglion cell-inner plexiform layer thickness: comparison with nerve fiber layer and optic nerve head.
abstract: OBJECTIVE
  To determine the diagnostic performance of macular ganglion cell-inner plexiform layer (GCIPL) thickness measured with the Cirrus high-definition optical coherence tomography (HD-OCT) ganglion cell analysis (GCA) algorithm (Carl Zeiss Meditec, Dublin, CA) to discriminate normal eyes and eyes with early glaucoma and to compare it with that of peripapillary retinal nerve fiber layer (RNFL) thickness and optic nerve head (ONH) measurements.
  
  
  METHODS
  Evaluation of diagnostic test or technology.
  
  
  METHODS
  Fifty-eight patients with early glaucoma and 99 age-matched normal subjects.
  
  
  METHODS
  Macular GCIPL and peripapillary RNFL thicknesses and ONH parameters were measured in each participant, and their diagnostic abilities were compared.
  
  
  METHODS
  Area under the curve (AUC) of the receiver operating characteristic.
  
  
  RESULTS
  The GCIPL parameters with the best AUCs were the minimum (0.959), inferotemporal (0.956), average (0.935), superotemporal (0.919), and inferior sector (0.918). There were no significant differences between these AUCs and those of inferior quadrant (0.939), average (0.936), and superior quadrant RNFL (0.933); vertical cup-to-disc diameter ratio (0.962); cup-to-disc area ratio (0.933); and rim area (0.910), all P>0.05.
  
  
  CONCLUSIONS
  The ability of macular GCIPL parameters to discriminate normal eyes and eyes with early glaucoma is high and comparable to that of the best peripapillary RNFL and ONH parameters.
  
  
  BACKGROUND
  Proprietary or commercial disclosure may be found after the references.
authors.affiliation: Bascom Palmer Eye Institute, Miami Miller School of Medicine, University of Miami, Miami, Florida, USA.
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Mwanza
authors.forename: Mary K
authors.initials: MK
authors.lastname: Durbin
authors.forename: Donald L
authors.initials: DL
authors.lastname: Budenz
authors.forename: Fouad E
authors.initials: FE
authors.lastname: Sayyad
authors.forename: Robert T
authors.initials: RT
authors.lastname: Chang
authors.forename: Arvind
authors.initials: A
authors.lastname: Neelakantan
authors.forename: David G
authors.initials: DG
authors.lastname: Godfrey
authors.forename: Randy
authors.initials: R
authors.lastname: Carter
authors.forename: Alan S
authors.initials: AS
authors.lastname: Crandall
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019540:Area Under Curve; D001369:Axons / Q000473:pathology*; D003430:Cross-Sectional Studies; D005189:False Positive Reactions; D005260:Female; D005901:Glaucoma / Q000175:diagnosis*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009898:Optic Disk / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000175:diagnosis*; D011237:Predictive Value of Tests; D012372:ROC Curve; D015203:Reproducibility of Results; D012165:Retinal Ganglion Cells / Q000473:pathology*; D012680:Sensitivity and Specificity; D041623:Tomography, Optical Coherence