title: CXCL12 in control of neuroinflammation.
abstract: Inflammation within the central nervous system (CNS) is strictly controlled and if possible prevented. Such a tight control is necessary due to high sensitivity of nervous tissue to mechanical and biochemical consequences of inflammation. Still, neuroinflammation is a typical feature of a chronic, inflammatory, demyelinating disease multiple sclerosis (MS) and its animal model experimental autoimmune encephalomyelitis (EAE). It is assumed that mechanisms that should prevent activation of immune cells at the periphery, in the lymphoid tissues, and/or inflammation within the CNS are inadequately efficient in MS patients. Here, some recent data about the importance of CXCL12 for regulation of neuroinflammation and contribution of its deviant expression within the CNS to EAE and MS pathogenesis are presented.
authors.affiliation: Department of Immunology, Institute for Biological Research Sinisa Stankovic, University of Belgrade, Despota Stefana 142, 11000 Belgrade, Serbia.
authors.forename: Miljana
authors.initials: M
authors.lastname: Momcilović
authors.forename: Marija
authors.initials: M
authors.lastname: Mostarica-Stojković
authors.forename: Djordje
authors.initials: D
authors.lastname: Miljković
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000473:pathology; D002490:Central Nervous System / Q000276:immunology / Q000473:pathology; D054377:Chemokine CXCL12 / Q000276:immunology* / Q000378:metabolism; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007249:Inflammation / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D009103:Multiple Sclerosis / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D015213:Neuroimmunomodulation; D051381:Rats
chemical_list: C515255:CXCL12 protein, human; D054377:Chemokine CXCL12