title: First case of breakthrough pneumonia due to Aspergillus nomius in a patient with acute myeloid leukemia.
abstract: We report the first known case of a breakthrough pulmonary infection caused by Aspergillus nomius in an acute myeloid leukemia patient receiving caspofungin therapy. The isolate was identified using matrix-assisted laser desorption ionization-time-of-flight mass spectrometry (MALDI-TOF MS) and sequencing-based methods. The organism was found to be fully susceptible, in vitro, to echinocandin antifungal agents.
authors.affiliation: Institute of Hematology, Università Cattolica del Sacro Cuore, Rome, Italy. morena.caira@rm.unicatt.it
authors.forename: Morena
authors.initials: M
authors.lastname: Caira
authors.forename: Brunella
authors.initials: B
authors.lastname: Posteraro
authors.forename: Maurizio
authors.initials: M
authors.lastname: Sanguinetti
authors.forename: Elena
authors.initials: E
authors.lastname: de Carolis
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Leone
authors.forename: Livio
authors.initials: L
authors.lastname: Pagano
mesh_terms: D000368:Aged; D000935:Antifungal Agents / Q000008:administration & dosage; D001230:Aspergillus / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D000077336:Caspofungin; D054714:Echinocandins / Q000008:administration & dosage; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications*; D055666:Lipopeptides; D008297:Male; D008826:Microbial Sensitivity Tests; D008853:Microscopy; D009172:Mycology / Q000379:methods; D010802:Phylogeny; D055732:Pulmonary Aspergillosis / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology*; D017422:Sequence Analysis, DNA; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D000935:Antifungal Agents; D054714:Echinocandins; D055666:Lipopeptides; D000077336:Caspofungin