title: Association between three genetic polymorphisms of glutathione S-transferase Z1 (GSTZ1) and susceptibility to bipolar disorder.
abstract: The association between polymorphisms of glutathione S-transferase Z1 (GSTZ1) and susceptibility to bipolar disorder (BPD) is investigated. This study was performed on 228 BPD patients and 234 control subjects. Among early-onset patients, the variant alleles of Glu32Lys and G-1002A increased BPD susceptibility. The haplotype "-1002G, 32Glu, 42Gly" versus the other haplotypes was significantly decreased among early-onset patients compared to controls (P=0.016).
authors.affiliation: Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Rezaei
authors.forename: Iraj
authors.initials: I
authors.lastname: Saadat
authors.forename: Mostafa
authors.initials: M
authors.lastname: Saadat
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001714:Bipolar Disorder / Q000235:genetics*; D016009:Chi-Square Distribution; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D018698:Glutamic Acid / Q000235:genetics; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium; D016015:Logistic Models; D008239:Lysine / Q000235:genetics; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D055815:Young Adult
chemical_list: D018698:Glutamic Acid; C407705:GSTZ1 protein, human; D005982:Glutathione Transferase; D008239:Lysine