title: [The impact of N, N-dimethylacetamide on the health of workers].
abstract: OBJECTIVE
  To explore the hepatic toxicity and the exposure biomarkers of N, N-Dimethylacetamide.
  
  
  METHODS
  One hundred forty five objects were chosen by stratified random sampling method. The investigation was performed using questionnaire and physical examination. The air concentrations of DMAC in the workshops were monitored. The urine samples were collected and analyzed after work everyday or at the weekend. The correlation between the air concentrations of DMAC in the workshops and the concentrations of urinary NMAC wee analyzed by regression.
  
  
  RESULTS
  The air concentration of DMAC in the spinning workshop was higher than others. The morbidity of abnormal hepatic function was 12.4%, 61.1% of workers with abnormal hepatic function appeared in one year after exposure to DMAC in the workshops ( r=0.44, P<0.01).
  
  
  CONCLUSIONS
  The abnormal heptic function was found in workers exposed to DMAC for short period. The concentration of urinary NMAC can serve as the exposure biomarker of DMAC.
authors.affiliation: Institute of Hygiene, Zhejiang Academy of Medical Sciences, Hangzhou, 310013, China.
authors.forename: Yan-yan
authors.initials: YY
authors.lastname: Lu
authors.forename: Hao
authors.initials: H
authors.lastname: Wu
authors.forename: Hong-fang
authors.initials: HF
authors.lastname: Tang
authors.forename: Zheng
authors.initials: Z
authors.lastname: Ruan
authors.forename: Dan-hua
authors.initials: DH
authors.lastname: Liu
authors.forename: Cheng-min
authors.initials: CM
authors.lastname: Xu
authors.forename: Ya-ling
authors.initials: YL
authors.lastname: Qian
mesh_terms: D000081:Acetamides / Q000633:toxicity* / Q000652:urine*; D000293:Adolescent; D000328:Adult; D000395:Air Pollutants, Occupational / Q000032:analysis*; D015415:Biomarkers / Q000652:urine; D004784:Environmental Monitoring; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D011795:Surveys and Questionnaires; D017132:Workplace; D055815:Young Adult
chemical_list: D000081:Acetamides; D000395:Air Pollutants, Occupational; D015415:Biomarkers; C013959:dimethylacetamide; C018595:N-methylacetamide