title: Effects of oral administration of Butyrivibrio fibrisolvens MDT-1 on the development and healing of atopic dermatitis in NC/Nga mice.
abstract: The purpose of this study was to evaluate the effects of oral administration of Butyrivibrio fibrisolvens MDT-1 (MDT-1) on mite antigen-induced atopic dermatitis (AD) in NC/Nga mice. When administration of the freeze-dried cells of MDT-1 was initiated one week before mite-antigen swabbing, the development of AD-like skin lesions was alleviated. The cell homogenate and membrane fraction had similar effects, showing that cell components are effective. Freeze-dried cells were found to be replaceable by the crude lipopolysaccharide extracted from MDT-1. Alleviation of AD was concomitant with a decrease in the serum IgE level. Determination of cytokines produced by Peyer's patch cells showed that MDT-1 administration increased IL-12, tended to increase IFN-γ, and tended to decrease IL-10, but did not affect IL-4. When MDT-1 was administered after the skin lesions had progressed, the symptoms were ameliorated, suggesting that MDT-1 has AD-healing effects. MDT-1 was as effective as prednisolone, but different from prednisolone in that MDT-1 showed no detectable side effects such as body weight loss. We previously reported that MDT-1 administration prevented and alleviated colorectal cancer, sarcoma, and enterocolitis in mice. Taken together, MDT-1 might be beneficial for maintaining the health of pet animals and humans.
authors.affiliation: Department of Life Science, Meiji University, Higashimita Tama-ku, Kawasaki, Japan.
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Hino
authors.forename: Kenta
authors.initials: K
authors.lastname: Suzuki
authors.forename: Sou
authors.initials: S
authors.lastname: Ohkawara
authors.forename: Takehiro
authors.initials: T
authors.lastname: Miwa
authors.forename: Narito
authors.initials: N
authors.lastname: Asanuma
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000941:Antigens; D002087:Butyrates / Q000627:therapeutic use*; D045856:Butyrivibrio; D003876:Dermatitis, Atopic / Q000097:blood / Q000139:chemically induced / Q000517:prevention & control*; D007073:Immunoglobulin E / Q000097:blood; D007371:Interferon-gamma / Q000097:blood; D016753:Interleukin-10 / Q000097:blood; D018664:Interleukin-12 / Q000097:blood; D015847:Interleukin-4 / Q000097:blood; D008070:Lipopolysaccharides; D008297:Male; D051379:Mice; D008925:Mites / Q000276:immunology
chemical_list: D000941:Antigens; D002087:Butyrates; D008070:Lipopolysaccharides; D016753:Interleukin-10; D018664:Interleukin-12; D015847:Interleukin-4; D007073:Immunoglobulin E; D007371:Interferon-gamma