title: The role of bacterial vaginosis and trichomonas in HIV transmission across the female genital tract.
abstract: Bacterial vaginosis (BV) and Trichomonas vaginalis (TV) infections are both very common and are associated with increased risk of sexual transmission of HIV. There are several mechanisms by which BV and TV could affect susceptibility including inducing pro-inflammatory cytokines and disrupting mucosal barrier function. This review highlights recent advances in our understanding of how these genital conditions lead to an increased risk of HIV infection in women.
authors.affiliation: Department of Immunology/Microbiology, Rush University Medical Center, Chicago, IL 60612, USA.
authors.forename: Paria
authors.initials: P
authors.lastname: Mirmonsef
authors.forename: Laurie
authors.initials: L
authors.lastname: Krass
authors.forename: Alan
authors.initials: A
authors.lastname: Landay
authors.forename: Gregory T
authors.initials: GT
authors.lastname: Spear
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000635:transmission*; D000818:Animals; D004198:Disease Susceptibility; D005260:Female; D015497:HIV-1 / Q000472:pathogenicity; D006801:Humans; D007113:Immunity, Innate; D007778:Lactobacillus / Q000472:pathogenicity*; D008251:Macaca; D012307:Risk Factors; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000635:transmission; D014247:Trichomonas Vaginitis / Q000276:immunology* / Q000382:microbiology / Q000662:veterinary; D014246:Trichomonas vaginalis / Q000472:pathogenicity*; D016585:Vaginosis, Bacterial / Q000276:immunology* / Q000382:microbiology / Q000662:veterinary