title: New insights about delayed allergic hypersensitivity to corticosteroids.
abstract: Corticosteroids are among the most commonly used drugs, both topically and systemically. Although unexpected and paradoxical, allergic hypersensitivity to corticosteroids is a common finding, delayed-type reactions being much more frequently encountered than the immediate-type ones. With regard to cross-reactions between corticosteroids, based on patch-test results and molecular modelling, we were recently able to simplify the previous classification into 3 different groups, i.e., Group 1: the non-methylated, most often non-halogenated molecules (Group A, D2 and budesonide), which produce most of the allergic reactions; Group 2: the halogenated molecules with a C16/C17 cis ketal/diol structure (acetonide Group B); and Group 3: the halogenated and C16-methylated molecules (Group C and D1) that only rarely produce allergy.
authors.affiliation: Departement of Dermatology, Saint-Luc University Clinic, Louvain Catholic University, Bruxelles, Belgium.
authors.forename: M
authors.initials: M
authors.lastname: Baeck
authors.forename: A
authors.initials: A
authors.lastname: Goossens
mesh_terms: D000305:Adrenal Cortex Hormones / Q000009:adverse effects* / Q000145:classification / Q000378:metabolism; D003875:Drug Eruptions / Q000209:etiology*; D004342:Drug Hypersensitivity / Q000209:etiology*; D054879:Halogenation; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000139:chemically induced* / Q000276:immunology*
chemical_list: D000305:Adrenal Cortex Hormones