title: The usefulness of the serum s100b protein for predicting delayed neurological sequelae in acute carbon monoxide poisoning.
abstract: BACKGROUND
  Some patients with acute carbon monoxide poisoning will experience delayed neurological sequelae. Several factors associated with delayed neurological sequelae have been reported, but these factors are unsatisfactory for the assessment of unconscious patients.
  
  
  OBJECTIVE
  The aim of this study was to assess the usefulness of the serum S100B protein as a biochemical marker for predicting delayed neurological sequelae.
  
  
  METHODS
  In this retrospective study, we evaluated the data for patients who visited an emergency medical center once during a period of 7 months. The enrollment criteria were the diagnosis of acute carbon monoxide poisoning and the measurement of the serum S100B level. A standardized extraction using medical records was performed.
  
  
  RESULTS
  A total of 71 patients were enrolled, and 10 patients (14.1%) presented delayed neurological sequelae. The delayed neurological sequelae group had a longer duration of carbon monoxide exposure, a longer duration of loss of consciousness, and a worse mental status (p-value < 0.001). In addition, the S100B protein levels were higher in the delayed neurological sequelae group (0.891 vs. 0.063, p-value < 0.001). Multiple logistic regression analysis showed that only the serum S100B protein level was independently associated with the development of delayed neurological sequelae (OR, 120.594; 95% CI, 4.194-3467.220), and a serum S100B protein level of more than 0.165 μg/L predicted the development of delayed neurological sequelae (sensitivity 90%, specificity 87%).
  
  
  CONCLUSIONS
  In the present study, the level of serum S100B protein was found to be useful for evaluating acute CO poisoning patients and was found to be an independent predictor of the development of DNS after acute CO poisoning.
authors.affiliation: Department of Emergency Medicine, Ajou University School of Medicine, Suwon, Republic of Korea.
authors.forename: Eunjung
authors.initials: E
authors.lastname: Park
authors.forename: Junghwan
authors.initials: J
authors.lastname: Ahn
authors.forename: Young-Gi
authors.initials: YG
authors.lastname: Min
authors.forename: Yoon-Seok
authors.initials: YS
authors.lastname: Jung
authors.forename: Kyuseok
authors.initials: K
authors.lastname: Kim
authors.forename: Jisook
authors.initials: J
authors.lastname: Lee
authors.forename: Sang-Cheon
authors.initials: SC
authors.lastname: Choi
mesh_terms: D000208:Acute Disease; D000328:Adult; D002249:Carbon Monoxide Poisoning / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D002263:Carboxyhemoglobin / Q000032:analysis; D005260:Female; D006785:Hospitals, University; D006801:Humans; D016015:Logistic Models; D008297:Male; D009414:Nerve Growth Factors / Q000097:blood*; D009422:Nervous System Diseases / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D011237:Predictive Value of Tests; D011379:Prognosis; D012372:ROC Curve; D012189:Retrospective Studies; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins / Q000097:blood*
chemical_list: D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579160:S100B protein, human; D002263:Carboxyhemoglobin