title: Microfluidics meets soft layer-by-layer films: selective cell growth in 3D polymer architectures.
abstract: We present here the micropatterns of layer-by-layer (LbL) assembled soft films generated using microfluidic platform that can be exploited for selective cell growth. Using this method, the issue of cell adhesion and spreading on soft LbL-derived films, and simultaneous utilisation of such unmodified soft films to exploit their reservoir properties are addressed. This also paves the way for extending the culture of cells to soft films and other demanding applications like triggered release of biomolecules.
authors.affiliation: Fraunhofer Institute for Biomedical Engineering, Am Mühlenberg 13, 14476 Potsdam-Golm, Germany.
authors.forename: Narayanan
authors.initials: N
authors.lastname: Madaboosi
authors.forename: Katja
authors.initials: K
authors.lastname: Uhlig
authors.forename: Stephan
authors.initials: S
authors.lastname: Schmidt
authors.forename: Magnus S
authors.initials: MS
authors.lastname: Jäger
authors.forename: Helmuth
authors.initials: H
authors.lastname: Möhwald
authors.forename: Claus
authors.initials: C
authors.lastname: Duschl
authors.forename: Dmitry V
authors.initials: DV
authors.lastname: Volodkin
mesh_terms: D000818:Animals; D002448:Cell Adhesion; D002460:Cell Line; D049109:Cell Proliferation; D004867:Equipment Design; D005347:Fibroblasts / Q000166:cytology*; D006820:Hyaluronic Acid / Q000737:chemistry*; D051379:Mice; D046210:Microfluidic Analytical Techniques / Q000295:instrumentation*; D018625:Microscopy, Atomic Force; D011107:Polylysine / Q000737:chemistry*; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D011107:Polylysine; D006820:Hyaluronic Acid