title: Anti-myelin oligodendrocyte glycoprotein antibodies in pediatric patients with optic neuritis.
abstract: OBJECTIVE
  To study the humoral immune response directed at myelin oligodendrocyte glycoprotein (MOG)in pediatric patients with isolated and recurrent optic neuritis(ON).
  
  
  METHODS
  Observational prospective case series.
  
  
  METHODS
  Six pediatric hospitals in Germany and Austria.
  
  
  METHODS
  Thirty-seven patients 18 years or younger with single or recurrent episodes of ON were recruited from 6 different hospitals.
  
  
  METHODS
  Clinical features, magnetic resonance imaging findings, intrathecal IgG synthesis,and outcome were recorded. A live cell–based immunofluorescence assay was used to measure serum IgG antibodies to MOG and aquaporin 4.
  
  
  RESULTS
  A single episode of ON was observed in 10 patients,and 15 experienced 2 to 12 episodes. The acute episode of ON was part of a clinically isolated syndrome in 12 patients, of whom 8 were subsequently classified as having multiple sclerosis. High-titer serum MOG-IgG antibodies (1:160) were detected in 17 patients (46%).In addition, high titers of MOG-IgG antibodies were more frequently observed in 12 of the 15 patients with recurrent episodes of ON (80%; median titer, 1:640)compared with 2 of the 10 patients with monophasic ON(20%; median titer, 0) and 3 of the 12 patients with ON as part of a clinically isolated syndrome (25%; median titer, 0).
  
  
  CONCLUSIONS
  High-titer MOG-IgG antibodies are predominantly detected in pediatric patients with recurrent ON, indicating that anti-MOG-specific antibodies may exert a direct role in the pathogenesis of ON in this subgroup.
authors.affiliation: Division of Pediatric Neurology and Inherited Metabolic Disorders, Department of Pediatrics IV, Innsbruck Medical University, Anichstrasse 35, A-6020 Innsbruck, Austria. kevin.rostasy@uki.at
authors.forename: Kevin
authors.initials: K
authors.lastname: Rostasy
authors.forename: Simone
authors.initials: S
authors.lastname: Mader
authors.forename: Kathrin
authors.initials: K
authors.lastname: Schanda
authors.forename: Peter
authors.initials: P
authors.lastname: Huppke
authors.forename: Jutta
authors.initials: J
authors.lastname: Gärtner
authors.forename: Verena
authors.initials: V
authors.lastname: Kraus
authors.forename: Michael
authors.initials: M
authors.lastname: Karenfort
authors.forename: Daniel
authors.initials: D
authors.lastname: Tibussek
authors.forename: Astrid
authors.initials: A
authors.lastname: Blaschek
authors.forename: Barbara
authors.initials: B
authors.lastname: Bajer-Kornek
authors.forename: Steffen
authors.initials: S
authors.lastname: Leitz
authors.forename: Mareike
authors.initials: M
authors.lastname: Schimmel
authors.forename: Franziska
authors.initials: F
authors.lastname: Di Pauli
authors.forename: Thomas
authors.initials: T
authors.lastname: Berger
authors.forename: Markus
authors.initials: M
authors.lastname: Reindl
mesh_terms: D000293:Adolescent; D051401:Aquaporin 4 / Q000276:immunology; D001317:Austria; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D005858:Germany; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism*; D008279:Magnetic Resonance Imaging; D008297:Male; D009185:Myelin Proteins / Q000276:immunology*; D063308:Myelin-Oligodendrocyte Glycoprotein; D043025:Oligoclonal Bands / Q000097:blood; D009902:Optic Neuritis / Q000276:immunology* / Q000378:metabolism*; D010372:Pediatrics; D011446:Prospective Studies; D018709:Statistics, Nonparametric
chemical_list: C496030:AQP4 protein, human; D051401:Aquaporin 4; D007074:Immunoglobulin G; C571326:MOG protein, human; D009185:Myelin Proteins; D063308:Myelin-Oligodendrocyte Glycoprotein; D043025:Oligoclonal Bands