title: Sedative load among community-dwelling people aged 75 years or older: association with balance and mobility.
abstract: Drugs with sedative properties are frequently used among older people. Sedative load is a measure of the cumulative effect of taking multiple drugs with sedative properties. The objective of this study was to investigate the association between sedative load and balance and mobility. A random sample of 1000 people 75 years or older was invited to participate. Seven hundred community-dwelling participants (mean age, 81.3 years; 69% women) were included in the present study. Demographic, diagnostic, and drug use data were elicited during nurse interviews in 2004. Balance and mobility were tested by physiotherapists. Sedative load was calculated using a previously published model for each participant by summing the sedative ratings of primary sedatives (rating 2) and drugs with sedation as a prominent adverse effect (rating 1). Analyses of covariance and logistic regression analyses were used to assess the association between sedative load and balance and mobility. Of the 700 participants, 21% (n = 147) had a sedative load of 1-2, and 8% (n = 58) had sedative load of 3 or greater. After adjusting for covariates, exposure to higher sedative load ranges was associated with slower walking speed (P = 0.0003), longer time to perform Timed Up and Go test (P = 0.005), and lower scores on Berg Balance Scale (P = 0.005), but not with self-reported ability to walk 400 m. In conclusion, having a higher sedative load was associated with impaired balance and mobility among community-dwelling older people. Clinicians should remain cognizant of this association and regularly reevaluate drug therapy prescribed to older people.
authors.affiliation: Kuopio Research Centre of Geriatric Care, University of Eastern Finland, Kuopio, Finland. heidi.taipale@uef.fi
authors.forename: Heidi T
authors.initials: HT
authors.lastname: Taipale
authors.forename: J Simon
authors.initials: JS
authors.lastname: Bell
authors.forename: Danijela
authors.initials: D
authors.lastname: Gnjidic
authors.forename: Raimo
authors.initials: R
authors.lastname: Sulkava
authors.forename: Sirpa
authors.initials: S
authors.lastname: Hartikainen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects / Q000627:therapeutic use*; D016015:Logistic Models; D008297:Male; D051346:Mobility Limitation; D008962:Models, Theoretical; D004856:Postural Balance / Q000187:drug effects*; D012111:Residence Characteristics / Q000706:statistics & numerical data; D013997:Time Factors; D016138:Walking / Q000706:statistics & numerical data*
chemical_list: D006993:Hypnotics and Sedatives