title: Synthesis and preliminary antihyperlipidaemic activities evaluation of andrographolide derivatives.
abstract: Recent studies indicated that andrographolide was a potential antihyperlipidaemic therapeutic agent. In the paper, the synthesis of a series of andrographolide derivatives was described and their antihyperlipidaemic activities were evaluated in vivo. As compared with TG, TC, HDL-C and LDL-C concentrations, some of the derivatives exhibited better antihyperlipidaemic effects than positive control atromide. Therein, compound 6i, which was the most potent compound, could serve as a new lead for further development of antihyperlipidaemic agents.
authors.affiliation: School of Pharmacy, China Pharmaceutical University, Nanjing 210009, People's Republic of China.
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.forename: Chunlei
authors.initials: C
authors.lastname: Tang
authors.forename: Yaodan
authors.initials: Y
authors.lastname: Han
authors.forename: Ruzhou
authors.initials: R
authors.lastname: Guo
authors.forename: Hai
authors.initials: H
authors.lastname: Qian
authors.forename: Wenlong
authors.initials: W
authors.lastname: Huang
mesh_terms: D000818:Animals; D004224:Diterpenes / Q000008:administration & dosage / Q000138:chemical synthesis / Q000627:therapeutic use*; D006949:Hyperlipidemias / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000008:administration & dosage / Q000138:chemical synthesis / Q000627:therapeutic use*; D008297:Male; D015394:Molecular Structure; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D004224:Diterpenes; D000960:Hypolipidemic Agents; C030419:andrographolide