title: Kaposiform hemangioendothelioma with Kasabach-Merritt phenomenon: successful treatment with embolization and vincristine in two newborns.
abstract: Kaposiform hemangioendothelioma (KHE) is a rare vascular tumor and has a high mortality in newborns when associated with Kasabach-Merritt syndrome (KMS). In two newborns with KHE and severe KMS refractory to medical treatment, emergency embolization led to clinical improvement in the acute neonatal setting by reducing tumor volume, increasing the platelet count, and improving other clotting parameters. Systemic vincristine treatment was added for further tumor control. Both patients remained symptom-free at long-term follow-up.
authors.affiliation: Vascular Anomalies Center, Hospital Italiano, Universidad de Buenos Aires, Ciudad de Buenos Aires, Argentina. ricardo.garciamonaco@hospitalitaliano.org.ar
authors.forename: Ricardo
authors.initials: R
authors.lastname: Garcia-Monaco
authors.forename: Ana
authors.initials: A
authors.lastname: Giachetti
authors.forename: Oscar
authors.initials: O
authors.lastname: Peralta
authors.forename: Noelia
authors.initials: N
authors.lastname: Napoli
authors.forename: Pablo
authors.initials: P
authors.lastname: Lobos
authors.forename: Laura
authors.initials: L
authors.lastname: Gioseffi
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Mariani
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage*; D001706:Biopsy; D001777:Blood Coagulation; D001780:Blood Coagulation Tests; D017024:Chemotherapy, Adjuvant; D004621:Embolization, Therapeutic; D005260:Female; D006390:Hemangioendothelioma / Q000097:blood / Q000098:blood supply / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D007231:Infant, Newborn; D059885:Kasabach-Merritt Syndrome / Q000097:blood / Q000098:blood supply / Q000175:diagnosis / Q000188:drug therapy*; D010976:Platelet Count; D020551:Pulse Therapy, Drug; D012514:Sarcoma, Kaposi / Q000097:blood / Q000098:blood supply / Q000175:diagnosis / Q000188:drug therapy*; D016896:Treatment Outcome; D047368:Tumor Burden / Q000187:drug effects; D014750:Vincristine / Q000008:administration & dosage*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014750:Vincristine