title: Metal-free synthesis of allylic amines by cross-dehydrogenative-coupling of 1,3-diarylpropenes with anilines and amides under mild conditions.
abstract: Dehydrogenative cross-coupling reaction of primary anilines, secondary anilines, carboxamides, and sulfonamides with 1,3-diarylpropenes to form a series of allylic amines promoted by DDQ have been realized. Both monoallylation and diallylation products can be selectively synthesized when primary anilines are used as the starting materials. The method may provide a wide scope of allylamines in scientific research including biologically active compound library construction.
authors.affiliation: Department of Chemistry, Zhejiang University (Xixi Campus), Hangzhou, Zhejiang 310028, China.
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Wang
authors.forename: Hanjie
authors.initials: H
authors.lastname: Mo
authors.forename: Dongping
authors.initials: D
authors.lastname: Cheng
authors.forename: Weiliang
authors.initials: W
authors.lastname: Bao
mesh_terms: D000498:Allyl Compounds / Q000138:chemical synthesis*; D000577:Amides / Q000737:chemistry*; D000588:Amines / Q000138:chemical synthesis*; D000814:Aniline Compounds / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D054852:Small Molecule Libraries; D013237:Stereoisomerism; D013449:Sulfonamides / Q000737:chemistry*
chemical_list: D000498:Allyl Compounds; D000577:Amides; D000588:Amines; D000814:Aniline Compounds; D054852:Small Molecule Libraries; D013449:Sulfonamides