title: Formulation development of a cream containing fennel extract: in vivo evaluation for anti-aging effects.
abstract: This study was aimed to formulate and evaluate anti-aging effects of a topical cream (w/o emulsion) containig extract of Fennel (Foeniculum vulgare) versus its base. Formulation containing 4% concentrated extract of Foeniculum vulgare was developed by entrapping in the inner aqueous phase of w/o emulsion and base contained no extract. Both the base and formulation were stored under different storage conditions to predict their stability. The formulation and base were evaluated for effect on skin moisture and transepidermal water loss (TEWL). The base showed insignificant while the formulation showed significant effects on skin moisture and TEWL. The parameter volume and surface evaluation of living skin (SELS) parameters SEr, SEsc, SEsm, SEw were also evaluated and showed a significant (p < or = 0.05) decline. The texture parameter energy showed a significant increase proving that the formulation possesses potential anti-aging effects.
authors.affiliation: Department of Pharmacy, Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur, Pakistan. akhtarasul@gmail.com
authors.forename: A
authors.initials: A
authors.lastname: Rasul
authors.forename: N
authors.initials: N
authors.lastname: Akhtar
authors.forename: B A
authors.initials: BA
authors.lastname: Khan
authors.forename: T
authors.initials: T
authors.lastname: Mahmood
authors.forename: S
authors.initials: S
authors.lastname: Uz Zaman
authors.forename: H M Shoaib
authors.initials: HM
authors.lastname: Khan
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D003116:Color; D004553:Electric Conductivity; D004655:Emulsions; D030001:Foeniculum / Q000737:chemistry*; D006801:Humans; D006813:Humidity; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D009824:Ointments; D010328:Patch Tests; D010851:Picrates / Q000737:chemistry; D010936:Plant Extracts / Q000009:adverse effects / Q000737:chemistry / Q000494:pharmacology; D012867:Skin / Q000737:chemistry; D015595:Skin Aging / Q000187:drug effects*; D012995:Solubility; D013499:Surface Properties; D013696:Temperature; D014870:Water Loss, Insensible
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D004655:Emulsions; D009824:Ointments; D010851:Picrates; D010936:Plant Extracts; C004931:1,1-diphenyl-2-picrylhydrazyl