title: Subarachnoid hemorrhage complicated with neurogenic pulmonary edema and takotsubo-like cardiomyopathy.
abstract: Patients with poor-grade subarachnoid hemorrhage (SAH) are often complicated with acute cardiopulmonary dysfunctions, particularly neurogenic pulmonary edema (NPE) and takotsubo-like cardiomyopathy (TCM). This study retrospectively investigated the incidence, demographics, clinical characteristics, and outcomes of patients with SAH complicated with both NPE and TCM (NPE-TCM). The effects of aneurysm location and other clinical variables on the incidence of NPE-TCM were also investigated. Among 234 SAH patients treated during 5-year period, 16 (7%) presented with NPE, and transthoracic ultrasonography revealed that 14 of these 16 patients (88%) also had TCM. All 14 patients with NPE-TCM had poor-grade SAH (World Federation of Neurosurgical Societies grades IV and V). Ruptured posterior circulation aneurysm was predictive of NPE-TCM, but other clinical variables were not. Eight of the 14 patients with NPE-TCM could undergo treatment for ruptured aneurysm. Long-term outcomes were favorable in 5 of the 8 patients. Grade IV SAH patients had significantly better outcomes than grade V patients. TCM develops frequently in SAH patients presenting with NPE, and transthoracic ultrasonography should be conducted routinely in that population. Patients with ruptured posterior circulation aneurysm may have elevated risk of developing NPE-TCM. Endovascular obliteration of the aneurysm may be preferable to open surgery, but the optimal treatment modality needs to be evaluated further. Considering the limited number of SAH patients complicated with NPE-TCM, a multi-center cooperative study may be required.
authors.affiliation: Department of Neurosurgery, Fujita Health University School of Medicine, Toyoake, Aichi, Japan. ginamasu@aol.com
authors.forename: Joji
authors.initials: J
authors.lastname: Inamasu
authors.forename: Masashi
authors.initials: M
authors.lastname: Nakatsukasa
authors.forename: Keita
authors.initials: K
authors.lastname: Mayanagi
authors.forename: Satoru
authors.initials: S
authors.lastname: Miyatake
authors.forename: Keiko
authors.initials: K
authors.lastname: Sugimoto
authors.forename: Takuro
authors.initials: T
authors.lastname: Hayashi
authors.forename: Yoko
authors.initials: Y
authors.lastname: Kato
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Hirose
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015897:Comorbidity / Q000639:trends; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011654:Pulmonary Edema / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology*; D012189:Retrospective Studies; D013345:Subarachnoid Hemorrhage / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology*; D054549:Takotsubo Cardiomyopathy / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000503:physiopathology*; D014463:Ultrasonography; D055815:Young Adult