title: Validation of the Brazilian version of Chronic Liver Disease Questionnaire.
abstract: OBJECTIVE
  The aim of this study was to validate the Chronic Liver Disease Questionnaire (CLDQ) for use in Brazilian population.
  
  
  METHODS
  A total of 200 patients with chronic liver disease and varying disease severity answered a socio-demographic questionnaire, t CLDQ, and the Medical Outcome Study Short Form 36 (SF-36). Patients returned in 1-15 days to answer CLDQ again. The Cronbach's alpha of the total CLDQ score was 0.95 and fluctuated between 0.69 and 0.83 in its six domains.
  
  
  RESULTS
  The intra-class correlation between total CLDQ scores in two evaluations was 0.97 and in all domains was >0.93. CLDQ was moderately correlated with the SF-36, 0.63 (total CLDQ vs. vitality, SF-36), 0.62 (CLDQ and mental health, SF-36), 0.62 (preoccupation, CLDQ, vs. General Health, SF-36), 0.59 (fatigue, CLDQ, vs. vitality, SF-36), 0.59 (activity, CLDQ, vs. vitality, SF-36), and 0.59 (fatigue, CLDQ, vs. mental health, SF-36). The highest scores were found in non-cirrhotic group. Child A patients had higher average scores than Child B and C groups in all domains, while patients with MELD <15 scored higher than patients with MELD ≥15.
  
  
  CONCLUSIONS
  CLDQ-BR was validated in Brazilian population and was appropriate for use in patients with liver disease of different etiologies and degrees of severity.
authors.affiliation: Department of Psychiatry, Universidade Federal de São Paulo, São Paulo, Brazil. sammucci@gmail.com
authors.forename: Samantha
authors.initials: S
authors.lastname: Mucci
authors.forename: Vanessa
authors.initials: V
authors.lastname: de Albuquerque Citero
authors.forename: Adriano Miziara
authors.initials: AM
authors.lastname: Gonzalez
authors.forename: Luciana
authors.initials: L
authors.lastname: Geocze
authors.forename: Stephan
authors.initials: S
authors.lastname: Geocze
authors.forename: Gaspar
authors.initials: G
authors.lastname: de Jesus Lopes Filho
authors.forename: Mario Alfredo
authors.initials: MA
authors.lastname: De Marco
authors.forename: Edison Roberto
authors.initials: ER
authors.lastname: Parise
authors.forename: Luiz Antonio Nogueira
authors.initials: LA
authors.lastname: Martins
mesh_terms: D000368:Aged; D001938:Brazil; D002648:Child; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000208:ethnology / Q000523:psychology*; D016031:Liver Transplantation; D008297:Male; D008603:Mental Health; D008875:Middle Aged; D011594:Psychometrics / Q000295:instrumentation; D011788:Quality of Life; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D018434:Sickness Impact Profile; D012959:Socioeconomic Factors; D011795:Surveys and Questionnaires; D014177:Translations