title: Dealing with uterine fibroids in reproductive medicine.
abstract: Women who wish to conceive are nowadays more likely to present with uterine fibroids, mainly because of the delay in childbearing in our society. The relationship between uterine fibroids and human reproduction is still controversial and counselling patients might sometimes be challenging. This paper is to assist those involved in the management of patients of reproductive age presenting with uterine fibroids. The interference of fibroids on fertility largely depends on their location. Submucous fibroids interfere with fertility and should be removed in infertile patients, regardless of the size or the presence of symptoms. Intramural fibroids distorting the cavity reduce the chances of conception, while investigations on intramural fibroids not distorting the cavity have so far given controversial results. No evidence supports the systematic removal of subserosal fibroids in asymptomatic, infertile patients. Myomectomy is still the 'gold standard' in fibroid treatment for fertility-wishing patients. In experienced hands, hysteroscopic myomectomy is minimally invasive, safe, and effective. Abdominal and laparoscopic myomectomy might be challenging, but potential risks could be reduced by new strategies and techniques.
authors.affiliation: Department of Obstetrics and Gynaecology, Uppsala University Hospital, Uppsala, Sweden. pietro.gambadauro@akademiska.se
authors.forename: P
authors.initials: P
authors.lastname: Gambadauro
mesh_terms: D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D005260:Female; D006801:Humans; D015907:Hysteroscopy; D007247:Infertility, Female / Q000209:etiology*; D010535:Laparoscopy; D007813:Laparotomy; D007889:Leiomyoma / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D055357:Uterine Artery Embolization; D014594:Uterine Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000628:therapy
chemical_list: D018931:Antineoplastic Agents, Hormonal