title: Autophagy prolongs survival after NFκB inhibition in B-cell lymphomas.
abstract: Autophagy allows cells to survive under conditions of nutrient deprivation. We have demonstrated that autophagy inhibitors are synthetically lethal with NFκB inhibitors in B-cell lymphomas because the NFκB pathway promotes survival by increasing glucose import. When NFκB is inhibited in B-cell lymphoma, glucose import decreases and cells become sensitive to perturbations in mitochondrial metabolism and autophagy. Thus, combined inhibition of autophagy and NFκB drives cells into metabolic crisis accelerating cell death.
authors.affiliation: Department of Medicine, Division of Infectious Diseases, Brigham and Women's Hospital, Boston, MA, USA.
authors.forename: Thomas G
authors.initials: TG
authors.lastname: Sommermann
authors.forename: Hildegard I D
authors.initials: HI
authors.lastname: Mack
authors.forename: Ellen
authors.initials: E
authors.lastname: Cahir-McFarland
mesh_terms: D001343:Autophagy; D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism; D002470:Cell Survival; D005947:Glucose / Q000378:metabolism; D051272:Glucose Transporter Type 1 / Q000378:metabolism; D006801:Humans; D051550:I-kappa B Kinase / Q000378:metabolism; D008214:Lymphocytes / Q000378:metabolism; D016393:Lymphoma, B-Cell / Q000188:drug therapy / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology*; D008954:Models, Biological; D016328:NF-kappa B / Q000037:antagonists & inhibitors* / Q000378:metabolism; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D051272:Glucose Transporter Type 1; D016328:NF-kappa B; D019869:Phosphatidylinositol 3-Kinases; D051550:I-kappa B Kinase; D005947:Glucose