title: Cross-coupling of aryllithiums with aryl and vinyl halides in flow microreactors.
abstract: The use of Pd catalysts that contained a carbene ligand, such as PEPPSI-SIPr, speeded up the Murahashi coupling of ArLi with ArBr, by enabling its integration with the Br/Li exchange of ArBr with BuLi in flow. Space integration realized the rapid cross-coupling of two different ArBr substrates. However, the cross-coupling reaction with vinyl halides could not be achieved under similar conditions. Pd(OAc)(2) was an effective catalyst, and the space integration of the Br/Li exchange of ArBr with BuLi and the Murahashi coupling with vinyl halides was successfully achieved.
authors.affiliation: Department of Synthetic and Biological Chemistry, Graduate School of Engineering, Kyoto University, Nishikyo-ku, Kyoto, 615-8510 Japan.
authors.forename: Aiichiro
authors.initials: A
authors.lastname: Nagaki
authors.forename: Yuya
authors.initials: Y
authors.lastname: Moriwaki
authors.forename: Suguru
authors.initials: S
authors.lastname: Haraki
authors.forename: Akira
authors.initials: A
authors.lastname: Kenmoku
authors.forename: Naofumi
authors.initials: N
authors.lastname: Takabayashi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Hayashi
authors.forename: Jun-Ichi
authors.initials: J
authors.lastname: Yoshida
mesh_terms: D002384:Catalysis; D006219:Halogens / Q000138:chemical synthesis / Q000737:chemistry*; D006841:Hydrocarbons, Aromatic / Q000138:chemical synthesis / Q000737:chemistry*; D008024:Ligands; D018020:Lithium Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry; D014753:Vinyl Compounds / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D006219:Halogens; D006841:Hydrocarbons, Aromatic; D008024:Ligands; D018020:Lithium Compounds; D014753:Vinyl Compounds; D010165:Palladium