title: Dibenzocyclooctadiene lignans from Kadsura coccinea.
abstract: In vitro anti-allergic screening of medicinal herbal extracts revealed that the EtOAc extract of the rhizoma of Kadsura coccinea inhibited nitric oxide (NO) production in a lipopolysaccharide and recombinant mouse interferon-γ activated murine macrophage-like cell line, RAW264.7. Further fractionation of the EtOAc extract led to the isolation of two new dibenzocyclooctadiene lignans kadsuralignan G (1) and kadsuralignan L (2), and three known analog compounds. The absolute stereostructures were established by circular dichroism spectra. Both 1 and 2 showed moderate NO production inhibitory activities.
authors.affiliation: College of Pharmacy, Soochow University, Suzhou 215123, China.
authors.forename: Wen
authors.initials: W
authors.lastname: Hu
authors.forename: Long
authors.initials: L
authors.lastname: Li
authors.forename: Qiong
authors.initials: Q
authors.lastname: Wang
authors.forename: Yong
authors.initials: Y
authors.lastname: Ye
authors.forename: Jie
authors.initials: J
authors.lastname: Fan
authors.forename: Hai-Xia
authors.initials: HX
authors.lastname: Li
authors.forename: Susumu
authors.initials: S
authors.lastname: Kitanaka
authors.forename: He-Ran
authors.initials: HR
authors.lastname: Li
mesh_terms: D000818:Animals; D018926:Anti-Allergic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002942:Circular Dichroism; D034242:Cyclooctanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D032135:Kadsura / Q000737:chemistry*; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D027343:Rhizome / Q000737:chemistry
chemical_list: D018926:Anti-Allergic Agents; D034242:Cyclooctanes; D017705:Lignans; D008070:Lipopolysaccharides; C510994:dibenzocyclooctadiene lignan; C571643:kadsuralignan G; C571642:kadsuralignan L; D009569:Nitric Oxide