title: Adult-onset cerebral folate deficiency.
abstract: OBJECTIVE
  To report new manifestations of cerebral folate deficiency, a rare metabolic autoimmune syndrome,in an adult.
  
  
  METHODS
  Case report.
  
  
  METHODS
  University teaching hospital.
  
  
  METHODS
  A 58-year-old woman with progressive memory loss and myoclonus presented for medical attention. Results of cerebral spinal fluid analysis showed low levels of tetrahydrobiopterin and 5-methyltetrahydrofolate. The patient's serum folate level was normal. Serum contained folate receptor 1 blocking and binding antibodies.
  
  
  RESULTS
  The patient was treated successfully with folinic acid supplementation, and after 6 months of treatment,clinical symptoms had resolved.
  
  
  CONCLUSIONS
  To our knowledge, we report the first case of adult-onset cerebral folate deficiency. Furthermore, this condition could represent a treatable form of early-onset dementia.
authors.affiliation: Departments of Pediatrics and Neuro-oncology, MD Anderson Cancer Center, University of Texas Medical School at Houston, Houston, TX 77030, USA.
authors.forename: Zsila
authors.initials: Z
authors.lastname: Sadighi
authors.forename: Ian J
authors.initials: IJ
authors.lastname: Butler
authors.forename: Mary Kay
authors.initials: MK
authors.lastname: Koenig
mesh_terms: D001927:Brain Diseases / Q000150:complications* / Q000178:diet therapy / Q000473:pathology*; D002540:Cerebral Cortex / Q000473:pathology*; D005260:Female; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008875:Middle Aged; D014804:Vitamin B Deficiency / Q000150:complications* / Q000178:diet therapy
chemical_list: D002955:Leucovorin