title: [Ten years' experience of preimplantation genetic diagnosis in Paris: remaining obstacles and potential solutions].
abstract: Preimplantation genetic diagnosis (PGD) has been authorized in France since 1999. Encouraging results have been obtained during the past 10 years in our Paris center, where 832 patients have undergone 1056 IVF-PGD procedures. With the advent of new techniques for the identification of genetic disease markers, our center can now offer PGD procedures for aneuploidy and 75 single-gene diseases. New indications for PGD have also been developed, such as mitochondrial DNA diseases, amyloid neuropathy, pulmonary arterial hypertension, and HLA typing The implantation rate is currently 29,6% and, by 31 December 2009, 151 healthy babies had been born. Unfortunately, demand for PGD procedures far outstrips available technical capacity, and the waiting period is longer than 18 months. Increased funding is urgently needed
authors.affiliation: Gynécologie-Obstétrique et Médecine de la Reproduction, Hôpital Antoine Béclère, Clamart. Univ. Paris-Sud, Clamart, INSERM, U782, Clamart, F-92140. rene.frydman@abc.aphp.fr
authors.forename: René
authors.initials: R
authors.lastname: Frydman
authors.forename: Nelly
authors.initials: N
authors.lastname: Achour-Frydman
authors.forename: Julie
authors.initials: J
authors.lastname: Steffann
authors.forename: Fredéric
authors.initials: F
authors.lastname: Lamazou
authors.forename: Renato
authors.initials: R
authors.lastname: Fanchin
authors.forename: Philippe
authors.initials: P
authors.lastname: Burlet
authors.forename: Nadine
authors.initials: N
authors.lastname: Gigarel
authors.forename: Serge
authors.initials: S
authors.lastname: Romana
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Bonnefont
authors.forename: Marc
authors.initials: M
authors.lastname: Le Lorch
authors.forename: Violaine
authors.initials: V
authors.lastname: Kerbrat
authors.forename: Laetitia
authors.initials: L
authors.lastname: Hesters
authors.forename: Arnold
authors.initials: A
authors.lastname: Munnich
authors.forename: Michel
authors.initials: M
authors.lastname: Vekemans
mesh_terms: D004624:Embryo Transfer / Q000706:statistics & numerical data; D005260:Female; D005307:Fertilization in Vitro; D005819:Genetic Markers; D006301:Health Services Needs and Demand; D006801:Humans; D010297:Paris; D011247:Pregnancy; D018873:Pregnancy Rate; D019836:Preimplantation Diagnosis / Q000706:statistics & numerical data* / Q000639:trends
chemical_list: D005819:Genetic Markers