title: Immunology in the clinic review series; focus on type 1 diabetes and viruses: the innate immune response to enteroviruses and its possible role in regulating type 1 diabetes.
abstract: Type 1 diabetes (T1D) is an autoimmune disease arising as a consequence of a misdirected T cell response to the pancreatic beta cell. In recent years, there has been a growing interest in the innate immune system as a regulator of disease development. Genome-wide association studies have identified diabetes-associated polymorphisms in genes encoding proteins with functions related to the innate immune response. Moreover, enteroviruses, known to activate a strong innate immune response, have been implicated in the disease pathogenesis. In this review, we discuss the innate immune response elicited by enteroviruses and how this response may regulate T1D development.
authors.affiliation: Department of Medicine HS, The Center for Infectious Medicine, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden.
authors.forename: K
authors.initials: K
authors.lastname: Lind
authors.forename: M H
authors.initials: MH
authors.lastname: Hühn
authors.forename: M
authors.initials: M
authors.lastname: Flodström-Tullberg
mesh_terms: D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology / Q000821:virology; D015551:Autoimmunity / Q000235:genetics* / Q000276:immunology; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics* / Q000276:immunology* / Q000821:virology; D004770:Enterovirus / Q000276:immunology; D004769:Enterovirus Infections / Q000276:immunology* / Q000821:virology; D055106:Genome-Wide Association Study; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics*; D050417:Insulin-Secreting Cells / Q000276:immunology / Q000821:virology; D051192:Receptors, Pattern Recognition / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D051192:Receptors, Pattern Recognition