title: Amplifications of NCOA3 gene in colorectal cancers in a Chinese population.
abstract: OBJECTIVE
  To investigate the copy number variation of NACO3 gene in colorectal cancer (CRC) and its correlation with tumor progression.
  
  
  METHODS
  A total of 142 samples of case-matched CRC tissues and adjacent normal tissues were obtained from patients undergoing bowel resection. Quantitative real-time polymerase chain reaction method was used to investigate the copy number variations of NCOA3 as well as gene expression in the collected tissues.
  
  
  RESULTS
  Copy number gains of NCOA3 were detected in 39 CRC samples (27.5%) and were correlated with tumor progression (χ2 = 6.42, P = 0.0112). Moreover, there was a positive correlation between copy number gain and mRNA over-expression of NCOA3 in CRCs (P = 0.0023). Expression level of NCOA3 mRNA was also enhanced in the CRC samples with unaltered copy numbers (3.85 ± 1.23 vs. 2.71 ± 0.64, P < 0.01).
  
  
  CONCLUSIONS
  Sporadic colorectal cancers exhibit different mechanisms of NCOA3 regulation.
authors.affiliation: Department of Histology and Embryology, Basic Medical College of Zhengzhou University, Zhengzhou 450001, Henan Province, China.
authors.forename: Zhi
authors.initials: Z
authors.lastname: Li
authors.forename: Zheng-Yu
authors.initials: ZY
authors.lastname: Fang
authors.forename: Yi
authors.initials: Y
authors.lastname: Ding
authors.forename: Wan-Tong
authors.initials: WT
authors.lastname: Yao
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.forename: Zhong-Qing
authors.initials: ZQ
authors.lastname: Zhu
authors.forename: Wen
authors.initials: W
authors.lastname: Wang
authors.forename: Qin-Xian
authors.initials: QX
authors.lastname: Zhang
mesh_terms: D044466:Asian People / Q000235:genetics*; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology*; D056915:DNA Copy Number Variations; D018450:Disease Progression; D005784:Gene Amplification; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D056921:Nuclear Receptor Coactivator 3 / Q000235:genetics*
chemical_list: C538866:NCOA3 protein, human; D056921:Nuclear Receptor Coactivator 3