title: Bioinformatics and systems biology.
abstract: Delivering personalized therapeutic options to cancer patients based on the genetic and molecular aberrations of the tumor offers great promise to improve the outcomes of cancer therapy. Significant progress in biotechnology has allowed the measurement of tens of thousands of "omic" data points across multiple levels (DNA, RNA protein, metabolomics) from a single tumor biopsy sample in a reasonable time frame for making clinical decisions. With this data in hand, the challenge from the bioinformatics and systems biology point of view is how does one convert data into information and knowledge that can improve the delivery of personalized therapy to the patient.
authors.affiliation: Department of Systems Biology, Institute for Personalized Cancer Therapy, The University of Texas, MD Anderson Cancer Center, Houston, TX 77054, USA. pram@mdanderson.org
authors.forename: Prahlad T
authors.initials: PT
authors.lastname: Ram
authors.forename: John
authors.initials: J
authors.lastname: Mendelsohn
authors.forename: Gordon B
authors.initials: GB
authors.lastname: Mills
mesh_terms: D001709:Biotechnology; D019295:Computational Biology; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D049490:Systems Biology