title: Effects of surface chemistry on the generation of reactive oxygen species by copper nanoparticles.
abstract: Mercaptocarboxylic acids with different carbon chain lengths were used for stabilizing uniform 15 nm copper nanoparticles. The effects of surface chemistry such as ligand type and surface oxidation on the reactive oxygen species (ROS) generated by the copper nanoparticles were examined. Transmission electron microscopy (TEM), powder X-ray diffraction (PXRD), UV-vis spectroscopy, and an acellular ROS assay show that ROS generation is closely related to the surface oxidation of copper nanoparticles. It was found that the copper nanoparticles with longer chain ligands had surfaces that were better protected from oxidation and a corresponding lower ROS generating capacity than did particles with shorter chain ligands. Conversely, the copper nanoparticles with greater surface oxidation also had higher ROS generating capacity.
authors.affiliation: Department of Chemical Engineering, University of Rochester, Gavett Hall 206, Rochester, New York 14627, USA.
authors.forename: Miao
authors.initials: M
authors.lastname: Shi
authors.forename: Hyun Soo
authors.initials: HS
authors.lastname: Kwon
authors.forename: Zhenmeng
authors.initials: Z
authors.lastname: Peng
authors.forename: Alison
authors.initials: A
authors.lastname: Elder
authors.forename: Hong
authors.initials: H
authors.lastname: Yang
mesh_terms: D055598:Chemical Phenomena; D003102:Colloids; D003300:Copper / Q000737:chemistry*; D008024:Ligands; D053768:Metal Nanoparticles / Q000737:chemistry*; D017382:Reactive Oxygen Species / Q000737:chemistry*; D013499:Surface Properties
chemical_list: D003102:Colloids; D008024:Ligands; D017382:Reactive Oxygen Species; D003300:Copper