title: [Physiological analysis of various types of osmotic diuresis].
abstract: Efficacy of drugs reduced proximal reabsorption was compared in experiments with female Wistar rats. Urine flow rate for the 1st h of experiment was enhanced after polyethylene glycol-400 (PEG) and 6% Na2SO4 infusion by over 30-fold, exenatide--40-fold, glycerol--11-fold as compared with the control. The maximal values of Na+ excretion were observed during Na2SO4 and exenatide administration (280 +/- 31 micromol/h vs. 3.2 +/- 0.6 Imol/h/100 g bw). The highest K+ excretion was revealed in experiments with glycerol administration (41 +/- 5 micromol/h vs. 7 +/- 2 micromol/h/100 g bw), Mg2+ --after exenatide injection (5.3 +/- 1.3 micromol/h vs. 0.16 +/- 0.03 micromol/ h/100 g bw). Diuretic effects were additive after combined administration of maximal doses of exenatide and PEG which suggests a different mechanism of action of solutes filtrated (PEG) to the proximal nephron segment and generated due to Na+/HW-exchange inhibition (exenatide). Osmotic diuretics differ by potency, mechanism of diuretic action and selectivity of ion excretion).
authors.forename: A S
authors.initials: AS
authors.lastname: Marina
authors.forename: A V
authors.initials: AV
authors.lastname: Kutina
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Natochin
mesh_terms: D000818:Animals; D002414:Cations, Monovalent / Q000652:urine; D004231:Diuresis / Q000187:drug effects* / Q000502:physiology; D004234:Diuretics, Osmotic / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects* / Q000502:physiology; D007668:Kidney / Q000502:physiology*; D009995:Osmosis / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012964:Sodium / Q000652:urine*
chemical_list: D002414:Cations, Monovalent; D004234:Diuretics, Osmotic; D012964:Sodium