title: Effects of a urolith prevention diet on urine compositions of glycosaminoglycans, Tamm-Horsfall glycoprotein, and nephrocalcin in cats with calcium oxalate urolithiasis.
abstract: OBJECTIVE
  To evaluate urine concentrations of glycosaminoglycans, Tamm-Horsfall glycoprotein, and nephrocalcin in cats fed a diet formulated to prevent calcium oxalate uroliths.
  
  
  METHODS
  10 cats with calcium oxalate urolithiasis.
  
  
  METHODS
  In a previous study conducted in accordance with a balanced crossover design, cats were sequentially fed 2 diets (the diet each cat was consuming prior to urolith detection and a diet formulated to prevent calcium oxalate uroliths). Each diet was fed for 8 weeks. At the end of each 8-week period, a 72-hour urine sample was collected. Concentrations of glycosaminoglycans, Tamm-Horsfall glycoprotein, and the 4 isoforms of nephrocalcin in urine samples collected during that previous study were measured in the study reported here. RESULTS; Diet had no effect on the quantity of Tamm-Horsfall glycoprotein and nephrocalcin in urine. However, the urine concentration of glycosaminoglycans was significantly higher during consumption of the urolith prevention diet.
  
  
  CONCLUSIONS
  Feeding a urolith prevention diet increased the urine concentration of glycosaminoglycans, which are glycoprotein inhibitors of growth and aggregation of calcium oxalate crystals.
authors.affiliation: Minnesota Urolith Center, College of Veterinary Medicine, University of Minnesota, Saint Paul, MN 55108, USA. lulic001@umn.edu
authors.forename: Jody P
authors.initials: JP
authors.lastname: Lulich
authors.forename: Carl A
authors.initials: CA
authors.lastname: Osborne
authors.forename: Mauricio
authors.initials: M
authors.lastname: Carvalho
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Nakagawa
mesh_terms: D000818:Animals; D001322:Autoanalysis / Q000662:veterinary; D002129:Calcium Oxalate / Q000737:chemistry; D002371:Cat Diseases / Q000178:diet therapy / Q000517:prevention & control / Q000652:urine*; D002415:Cats; D018592:Cross-Over Studies; D005260:Female; D006023:Glycoproteins / Q000652:urine*; D006025:Glycosaminoglycans / Q000652:urine*; D008297:Male; D052878:Urolithiasis / Q000178:diet therapy / Q000517:prevention & control / Q000652:urine / Q000662:veterinary*; D058949:Uromodulin / Q000652:urine*
chemical_list: D006023:Glycoproteins; D006025:Glycosaminoglycans; D058949:Uromodulin; C029490:nephrocalcin; D002129:Calcium Oxalate