title: FCRL3 gene polymorphisms contribute to the radiographic severity rather than susceptibility of rheumatoid arthritis.
abstract: The ethnic heterogeneity and genetic complexity of rheumatoid arthritis (RA) have produced inconsistent results in previous genetic association studies concerning FCRL3. This study sought to delineate the association between the FCRL3 gene polymorphisms and susceptibility to RA and to investigate the effects of the polymorphisms on the progression of joint destruction in RA. RA patients (n = 377) and healthy unrelated controls (n = 298) were recruited. Genotyping of -169 T>C and -110 G>A in the promoter and 1,381 G>A in the intron was accomplished using FRET assays. The distribution of genotypes and haplotypes did not differ between RA patients and controls. When we investigated the role of FCRL3 polymorphisms for the severity of RA, patients with the CC genotype in the -169 T>C polymorphism had a higher modified Sharp score than other genotype groups (p = 0.034) among patients with disease duration ≥10 years. The slope of the regression line for modified Sharp score over disease duration (10.12/year) was significantly steeper in patients with the CC genotype than in the T carriers (5.69/year) at the -169 T>C polymorphism (p = 0.003), indicating the faster progression of radiologic destruction in the CC genotype. In conclusion, polymorphisms of the FCRL3 gene may contribute to the progression of joint destruction rather than susceptibility of RA.
authors.affiliation: Department of Internal Medicine, Daegu Fatima Hospital, Daegu, Republic of Korea.
authors.forename: Seung Woo
authors.initials: SW
authors.lastname: Han
authors.forename: Keum Hee
authors.initials: KH
authors.lastname: Sa
authors.forename: Sung Il
authors.initials: SI
authors.lastname: Kim
authors.forename: Sang Il
authors.initials: SI
authors.lastname: Lee
authors.forename: Yong Wook
authors.initials: YW
authors.lastname: Park
authors.forename: Shin Seok
authors.initials: SS
authors.lastname: Lee
authors.forename: Wan Hee
authors.initials: WH
authors.lastname: Yoo
authors.forename: Jin Young
authors.initials: JY
authors.lastname: Kang
authors.forename: Jae Seok
authors.initials: JS
authors.lastname: Soe
authors.forename: Eon Jeong
authors.initials: EJ
authors.lastname: Nam
authors.forename: Jongmin
authors.initials: J
authors.lastname: Lee
authors.forename: Jae Yong
authors.initials: JY
authors.lastname: Park
authors.forename: Young Mo
authors.initials: YM
authors.lastname: Kang
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging / Q000235:genetics* / Q000473:pathology*; D001175:Arthrography; D016022:Case-Control Studies; D016172:DNA Fingerprinting; D005260:Female; D018740:Genetic Heterogeneity; D006239:Haplotypes; D006801:Humans; D007438:Introns; D007596:Joints / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D011971:Receptors, Immunologic / Q000235:genetics*; D017422:Sequence Analysis, DNA; D012720:Severity of Illness Index
chemical_list: C457775:FCRL3 protein, human; D011971:Receptors, Immunologic