title: Pandemic and seasonal vaccine coverage and effectiveness during the 2009-2010 pandemic influenza in an Italian adult population.
abstract: OBJECTIVE
  To evaluate the response to pandemic vaccination and seasonal and pandemic vaccine effectiveness (VE) in an Italian adult population, during the 2009-2010 influenza season.
  
  
  METHODS
  Data were recorded by interviewing 19,275 subjects (≥35 years), randomly recruited from the general population of the Moli-sani project. Events [influenza-like illness (ILI), hospitalization and death], which had occurred between 1 November 2009 and 31 January 2010 were considered. VE was analyzed by multivariable Poisson regression analysis.
  
  
  RESULTS
  Pandemic vaccine coverage was very low (2.4%) in subjects at high-flu risk, aged 35-65 years (N = 8,048); there was no significant preventive effect of vaccine against ILI. Seasonal vaccine coverage was 26.6% in the whole population (63% in elderly and 21.9% in middle-aged subjects at high-flu risk). There was a higher risk to develop ILI in middle-age [VE: -17% (95% CI: -35,-1)] or at high flu-risk [VE: -17% (95% CI: -39, 2)] vaccinated groups.
  
  
  CONCLUSIONS
  Coverage of pandemic vaccine was very low in a Southern Italy population, with no protective effect against ILI.
authors.affiliation: Laboratory of Genetic and Environmental Epidemiology, Research Laboratories, Fondazione di Ricerca e Cura Giovanni Paolo II, Largo Gemelli 1, 86100, Campobasso, Italy.
authors.forename: Simona
authors.initials: S
authors.lastname: Costanzo
authors.forename: Francesco
authors.initials: F
authors.lastname: Gianfagna
authors.forename: Mariarosaria
authors.initials: M
authors.lastname: Persichillo
authors.forename: Francesca
authors.initials: F
authors.lastname: De Lucia
authors.forename: Francesca D
authors.initials: FD
authors.lastname: Lucia
authors.forename: Angelita
authors.initials: A
authors.lastname: Verna
authors.forename: Modjenar
authors.initials: M
authors.lastname: Djidingar
authors.forename: Sara
authors.initials: S
authors.lastname: Magnacca
authors.forename: Francesca
authors.initials: F
authors.lastname: Bracone
authors.forename: Marco
authors.initials: M
authors.lastname: Olivieri
authors.forename: Maria Benedetta
authors.initials: MB
authors.lastname: Donati
authors.forename: Giovanni
authors.initials: G
authors.lastname: de Gaetano
authors.forename: Licia
authors.initials: L
authors.lastname: Iacoviello
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D017589:Immunization Programs / Q000706:statistics & numerical data; D007251:Influenza, Human / Q000453:epidemiology* / Q000517:prevention & control*; D007407:Interviews as Topic; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D058873:Pandemics; D016012:Poisson Distribution; D015397:Program Evaluation