title: Healthy growth in children with Down syndrome.
abstract: OBJECTIVE
  To provide cross-sectional height and head circumference (HC) references for healthy Dutch children with Down syndrome (DS), while considering the influence of concomitant disorders on their growth, and to compare growth between children with DS and children from the general population.
  
  
  METHODS
  Longitudinal growth and medical data were retrospectively collected from medical records in 25 of the 30 regional hospital-based outpatient clinics for children with DS in The Netherlands. Children with Trisomy 21 karyotype of Dutch descent born after 1982 were included. The LMS method was applied to fit growth references.
  
  
  RESULTS
  We enrolled 1,596 children, and collected 10,558 measurements for height and 1,778 for HC. Children with DS without concomitant disorders (otherwise healthy children) and those suffering only from mild congenital heart defects showed similar growth patterns. The established growth charts, based on all measurements of these two groups, demonstrate the three age periods when height differences between children with and without DS increase: during pregnancy, during the first three years of life, and during puberty. This growth pattern results in a mean final height of 163.4 cm in boys and 151.8 cm in girls (-2.9 standard deviation (SD) and -3.0 SD on general Dutch charts, respectively). Mean HC (0 to 15 months) was 2 SD less than in the general Dutch population. The charts are available at www.tno.nl/growth.
  
  
  CONCLUSIONS
  Height and HC references showed that growth retardation in otherwise healthy children with DS meanly occurs in three critical periods of growth, resulting in shorter final stature and smaller HC than the general Dutch population shows. With these references, health care professionals can optimize their preventive care: monitoring growth of individual children with DS optimal, so that growth retarding comorbidities can be identified early, and focusing on the critical age periods to establish ways to optimize growth.
authors.affiliation: Department of Child Health, Netherlands Organization for Applied Scientific Research (TNO), Leiden, The Netherlands. helma.vangameren@tno.nl
authors.forename: Helma B M
authors.initials: HB
authors.lastname: Van Gameren-Oosterom
authors.forename: Paula
authors.initials: P
authors.lastname: Van Dommelen
authors.forename: Anne Marie
authors.initials: AM
authors.lastname: Oudesluys-Murphy
authors.forename: Simone E
authors.initials: SE
authors.lastname: Buitendijk
authors.forename: Stef
authors.initials: S
authors.lastname: Van Buuren
authors.forename: Jacobus P
authors.initials: JP
authors.lastname: Van Wouwe
mesh_terms: D000293:Adolescent; D000328:Adult; D001827:Body Height / Q000502:physiology; D002508:Cephalometry; D002648:Child; D002675:Child, Preschool; D004314:Down Syndrome / Q000503:physiopathology*; D005260:Female; D048788:Growth and Development; D006262:Health; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009426:Netherlands; D012015:Reference Standards; D055815:Young Adult