title: [Crucial role of TNFα-induced adipose-related protein (TIARP) in the pathogenesis of autoimmune arthritis].
abstract: Rheumatoid arthritis (RA) is a chronic inflammatory disorder with a variable disease outcome, and is characterized by inflammation of multiple joints. Proinflammtory cytokines, such as tumor necrosis factor alpha (TNFα), interleukin-6 (IL-6) are thought to play crucial roles in the pathology of RA. The prognosis of patients with RA has improved significantly with the recent availability of biologics targeting TNFα and IL-6. Immunization of DBA/1 mice with glucose-6-phosphate isomerase (GPI) induces severe acute arthritis. This arthritis can be controlled by TNFα antagonists, suggesting similar etiology to RA. We performed GeneChip analysis using splenocytes of mice with GPI-induced arthritis. Among the arrayed TNFα-related genes, the expression of TNFα-induced adipose-related protein (TIARP) mRNA was the highest. TIARP was detected specifically in joints and spleens of arthritic mice. Among the splenocytes, CD11b(+) cells were the main source of TIARP mRNA. STEAP4 (the human ortholog of TIARP) was highly upregulated in joints of patients with RA and especially co-localized with CD68(+) macrophages. In this study, we discuss the role of TIARP in the generation of experimental autoimmune arthritis and the possible clinical application of for the treatment of RA.
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, University of Tsukuba.
authors.forename: Asuka
authors.initials: A
authors.lastname: Inoue
authors.forename: Isao
authors.initials: I
authors.lastname: Matsumoto
authors.forename: Yoko
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Takayuki
authors.initials: T
authors.lastname: Sumida
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000235:genetics / Q000276:immunology* / Q000628:therapy; D004195:Disease Models, Animal; D005786:Gene Expression Regulation; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics / Q000276:immunology*; D010088:Oxidoreductases / Q000235:genetics / Q000276:immunology*
chemical_list: D008565:Membrane Proteins; C436323:Tiarp protein, mouse; D010088:Oxidoreductases; C503310:STEAP4 protein, human