title: Parallel development and course of pheochromocytoma and giant squamous cell carcinoma of the leg: a new paraneoplastic syndrome?
abstract: Paraneoplastic syndromes (PS) are diseases or symptom complexes associated with malignancy, usually of internal origin, but not directly related to mass effects, invasion, or metastatic spread. Rarely, cutaneous squamous cell carcinoma (SCC) may be associated with PS. We present a patient with a giant SCC located on the right leg and a pheochromocytoma. Considering the concurrent onset and parallel course of both pheochromocytoma and SCC in this patient, and the complete resolution of the endocrine abnormalities after resection of the skin tumor, it was possible to conceive of the pheochromocytoma as a paraneoplastic phenomenon. To our knowledge, this association has not been previously described.
authors.affiliation: Department of Dermatovenereology, Hospital S. João, Alameda Professor Hernâni Monteiro, Porto, Portugal. paulomoraiscardoso@gmail.com
authors.forename: Paulo
authors.initials: P
authors.lastname: Morais
authors.forename: Teresa
authors.initials: T
authors.lastname: Baudrier
authors.forename: António
authors.initials: A
authors.lastname: Santos
authors.forename: Alberto
authors.initials: A
authors.lastname: Mota
authors.forename: Ana Filipa
authors.initials: AF
authors.lastname: Duarte
authors.forename: Jesus
authors.initials: J
authors.lastname: Ventura
authors.forename: Filomena
authors.initials: F
authors.lastname: Azevedo
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000175:diagnosis / Q000601:surgery; D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000601:surgery; D006801:Humans; D007866:Leg; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis / Q000601:surgery; D010257:Paraneoplastic Syndromes / Q000175:diagnosis / Q000601:surgery; D010673:Pheochromocytoma / Q000175:diagnosis / Q000601:surgery; D012878:Skin Neoplasms / Q000175:diagnosis / Q000601:surgery