title: Synthesis and preliminary antibacterial evaluation of Linezolid-like 1,2,4-oxadiazole derivatives.
abstract: In the present study the synthesis of new Linezolid-like molecules has been achieved by substitution of the oxazolidinone central heterocyclic moiety with a 1,2,4-oxadiazole ring. Two series of 1,2,4-oxadiazoles, bearing different side-chains and containing a varying number of fluorine atoms, were synthesized and preliminarily tested for biological activity against some Gram-positive and Gram-negative bacteria using Linezolid and Ceftriaxone as reference drugs.
authors.affiliation: Dipartimento di Scienze e Tecnologie Molecolari e Biomolecolari, Sez. Chimica Organica E. Paternò, Università degli Studi di Palermo, Viale delle Scienze, Ed. 17, Parco D'Orleans II, I-90128, Palermo, Italy.
authors.forename: Antonio
authors.initials: A
authors.lastname: Palumbo Piccionello
authors.forename: Rosario
authors.initials: R
authors.lastname: Musumeci
authors.forename: Clementina
authors.initials: C
authors.lastname: Cocuzza
authors.forename: Cosimo Gianluca
authors.initials: CG
authors.lastname: Fortuna
authors.forename: Annalisa
authors.initials: A
authors.lastname: Guarcello
authors.forename: Paola
authors.initials: P
authors.lastname: Pierro
authors.forename: Andrea
authors.initials: A
authors.lastname: Pace
mesh_terms: D000081:Acetamides / Q000737:chemistry* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D002443:Ceftriaxone / Q000494:pharmacology; D000069349:Linezolid; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D023303:Oxazolidinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D002443:Ceftriaxone; D000069349:Linezolid