title: Atherosclerosis in chronic kidney disease: lessons learned from glycation in diabetes.
abstract: In diabetes, glycation is a nonenzymatic posttranslational modification resulting from the bonding of a sugar molecule with a protein or lipid followed by oxidation, resulting in the development of advanced glycation end products (AGE). Like glycation, carbamylation is a posttranslational protein modification that is associated with AGE formation. Glycation of extracellular matrix proteins and low-density lipoprotein with subsequent deposition in the vessel wall could contribute to inflammatory response and atheroma formation. It is logical to extrapolate that carbamylation may result in modification of vessel wall proteins similar to glycation, and predispose to atherosclerosis.
authors.affiliation: Division of Cardiology, University of California-Irvine School of Medicine, Orange, CA 92868-3298, USA. dmohar@uci.edu
authors.forename: Dilbahar S
authors.initials: DS
authors.lastname: Mohar
authors.forename: Ailin
authors.initials: A
authors.lastname: Barseghian
authors.forename: Nezam
authors.initials: N
authors.lastname: Haider
authors.forename: Michael
authors.initials: M
authors.lastname: Domanski
authors.forename: Jagat
authors.initials: J
authors.lastname: Narula
mesh_terms: D050197:Atherosclerosis / Q000150:complications / Q000378:metabolism*; D050260:Carbohydrate Metabolism; D002908:Chronic Disease; D048909:Diabetes Complications / Q000378:metabolism*; D005455:Fluorescent Antibody Technique; D017127:Glycation End Products, Advanced / Q000378:metabolism*; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D007674:Kidney Diseases / Q000150:complications / Q000378:metabolism*; D050356:Lipid Metabolism; D008077:Lipoproteins, LDL / Q000378:metabolism*; D010084:Oxidation-Reduction; D058226:Plaque, Atherosclerotic / Q000150:complications / Q000378:metabolism*; D012307:Risk Factors; D017539:Tunica Intima / Q000378:metabolism
chemical_list: D017127:Glycation End Products, Advanced; D018836:Inflammation Mediators; D008077:Lipoproteins, LDL