title: Organic glues or fibrin glues from pooled plasma: efficacy, safety and potential as scaffold delivery systems.
abstract: Since 1976, fibrin glues have been attracting medical interest, spreading from their initial use as a hemostatic agent in cardiovascular surgery to other fields of surgery. Studies have compared the efficacy of fibrin glues vs sutures in surgery. However, few comparisons have been made of the efficacy and safety of the different fibrin glues commercially available. Recently, fibrin glues have been tested as a scaffold delivery system for various substances inside the body (drugs, growth factors, stem cells). The infectious risk (viruses, new germs) of this blood-derived product was also studied in assays on viral inactivation methods. The development of autologous fibrin glues offers a solution to the problem of infectious risk. This review examines the current state of knowledge on the efficacy, safety and future potential of fibrin glues.
authors.affiliation: Laboratoire de Pharmaco-Chimie Radicalaire, Universités d'Aix-Marseille I, Marseille, France. marc.montana@univ-amu.fr
authors.forename: Marc
authors.initials: M
authors.lastname: Montana
authors.forename: Clémence
authors.initials: C
authors.lastname: Tabélé
authors.forename: Christophe
authors.initials: C
authors.lastname: Curti
authors.forename: Thierry
authors.initials: T
authors.lastname: Terme
authors.forename: Pascal
authors.initials: P
authors.lastname: Rathelot
authors.forename: Sophie
authors.initials: S
authors.lastname: Gensollen
authors.forename: Patrice
authors.initials: P
authors.lastname: Vanelle
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems; D015718:Fibrin Tissue Adhesive / Q000009:adverse effects / Q000737:chemistry*; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000008:administration & dosage; D010949:Plasma; D033581:Stem Cell Transplantation / Q000379:methods; D054457:Tissue Scaffolds / Q000009:adverse effects / Q000737:chemistry*
chemical_list: D015718:Fibrin Tissue Adhesive; D036341:Intercellular Signaling Peptides and Proteins