title: [Neurologic paraneoplastic syndrome with anti-CV2/CRMP5 antibodies revealing a small cell lung cancer. Effectiveness of the lung cancer treatment].
abstract: BACKGROUND
  Paraneoplastic neurological syndrome associated with anti-CV2/CRMP5 antibodies are rare. Various clinical manifestations can occur, cerebellar ataxia, polyneuropathy, optic neuritis with NORB or uveitis. Small cell lung carcinoma is generally responsible.
  
  
  METHODS
  We report the case of a 64-year-old man who developed visual symptoms with papilledema, cerebellar signs, polyneuropathy confirmed with a neurophysiological studies. Anti-CV2/CRMP5 antibodies were present. A small cell lung carcinoma was responsible for this paraneoplastic syndrome revealing the cancer. The paraneoplastic syndrome improved with radio chemotherapy of the cancer alone.
  
  
  CONCLUSIONS
  A paraneoplastic neurological syndrome must be evoked in case of an atypic neurological syndrome. This diagnostic can be confirmed by the presence of anti-neuronal antibodies. In this case, a small cells cancer of the lung must be research.
authors.affiliation: Service de pneumologie, hôpital Tenon, 4, rue de la Chine, 75970 Paris, France.
authors.forename: L
authors.initials: L
authors.lastname: Rosencher
authors.forename: T
authors.initials: T
authors.lastname: Maisonobe
authors.forename: A
authors.initials: A
authors.lastname: Lavole
authors.forename: B
authors.initials: B
authors.lastname: Milleron
authors.forename: J-P
authors.initials: JP
authors.lastname: Ferroir
mesh_terms: D024221:Antineoplastic Protocols; D001323:Autoantibodies / Q000097:blood / Q000302:isolation & purification*; D020274:Autoimmune Diseases of the Nervous System / Q000097:blood / Q000175:diagnosis / Q000209:etiology / Q000276:immunology / Q000628:therapy; D003937:Diagnosis, Differential; D006801:Humans; D006867:Hydrolases; D008175:Lung Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy*; D008297:Male; D008869:Microtubule-Associated Proteins; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000276:immunology; D020361:Paraneoplastic Syndromes, Nervous System / Q000097:blood / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy*; D055752:Small Cell Lung Carcinoma / Q000150:complications / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy*; D016896:Treatment Outcome
chemical_list: D001323:Autoantibodies; D008869:Microtubule-Associated Proteins; D009419:Nerve Tissue Proteins; C415087:DPYSL5 protein, human; D006867:Hydrolases