title: [Neonatal lesions of catecholaminergic system prevents maturation of cholinergic innervation of the rat neocortex].
abstract: The influence ofcatecholaminergic system on functioning of the somatosensory and cholinergic systems in early ontogenesis in rats was studied. The neonatal systemic administration of the neurotoxin 6-hydroxydopamine modifies sensitivity of neurons in the somatosensory cortex to peripheral stimulation (stimulation of the sciatic nerve). It is shown that in animals with lesions, catecholaminergic system reduces the number of the cortical neurons responsive to stimulation of ascending cholinergic pathways. The sensitivity of these neurons to acetylcholine does not change. The damage in the early ontogeny catecholaminergic mechanisms seems to prevent maturation of cholinergic afferents in the neocortex.
authors.forename: V V
authors.initials: VV
authors.lastname: Raevskiĭ
mesh_terms: D000109:Acetylcholine / Q000502:physiology; D000818:Animals; D000831:Animals, Newborn; D001285:Atropine / Q000378:metabolism; D002395:Catecholamines / Q000494:pharmacology / Q000502:physiology*; D019579:Neocortex / Q000187:drug effects / Q000254:growth & development*; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D016627:Oxidopamine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012584:Sciatic Nerve / Q000187:drug effects; D013003:Somatosensory Cortex / Q000187:drug effects / Q000254:growth & development / Q000502:physiology
chemical_list: D002395:Catecholamines; D001285:Atropine; D016627:Oxidopamine; D000109:Acetylcholine