title: Early diagnosis of invasive pulmonary aspergillosis in a young immunocompetent patient.
abstract: A 22-year-old insulin-dependent diabetic male was admitted for diabetic ketoacidosis. He developed hospital-acquired pneumonia (HAP) for which empirical antibiotic and antifungal therapy was started on the ward. On day 6, clinical and laboratory findings worsened, and bronchoalveolar lavage (BAL) was performed. Serum real time-polymerase chain reaction (RT-PCR) indicated invasive pulmonary aspergillosis (IPA) and led to antifungal therapy being initiated 48 hours before the results of the BAL culture were available. Despite early appropriate antifungal therapy, however, the patient died on day 22 while being supported by venovenous extracorporeal membrane oxygenation.
authors.affiliation: Universita del Piemonte Orientale, Dipartimento di Medicina Clinica e Sperimentale, Anestesia e Terapia Intensiva, Novara, Italy.
authors.forename: Rosanna
authors.initials: R
authors.lastname: Vaschetto
authors.forename: Vesselina
authors.initials: V
authors.lastname: Kroumova
authors.forename: Carlo
authors.initials: C
authors.lastname: Olivieri
authors.forename: Valentina
authors.initials: V
authors.lastname: Bergamaschi
authors.forename: Laura
authors.initials: L
authors.lastname: Cancelliere
authors.forename: Silvio
authors.initials: S
authors.lastname: Borrè
authors.forename: Giacomo
authors.initials: G
authors.lastname: Fortina
authors.forename: Paolo
authors.initials: P
authors.lastname: Navalesi
authors.forename: Francesco
authors.initials: F
authors.lastname: Della Corte
mesh_terms: D000890:Anti-Infective Agents / Q000627:therapeutic use; D003428:Cross Infection / Q000150:complications / Q000188:drug therapy; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D017809:Fatal Outcome; D006801:Humans; D007121:Immunocompetence; D055744:Invasive Pulmonary Aspergillosis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D011014:Pneumonia / Q000150:complications / Q000188:drug therapy; D055815:Young Adult
chemical_list: D000890:Anti-Infective Agents