title: Turmeric (Curcuma longa L.) volatile oil inhibits key enzymes linked to type 2 diabetes.
abstract: Anti-diabetic capacity of Curcuma longa volatile oil in terms of its ability to inhibit glucosidase activities was evaluated. Turmeric volatile oils inhibited glucosidase enzymes more effectively than the reference standard drug acarbose. Drying of rhizomes was found to enhance α-glucosidase (IC₅₀ = 1.32-0.38 μg/ml) and α-amylase (IC₅₀ = 64.7-34.3 μg/ml) inhibitory capacities of volatile oils. Ar-Turmerone, the major volatile component in the rhizome also showed potent α-glucosidase (IC₅₀ = 0.28 μg) and α-amylase (IC₅₀ = 24.5 μg) inhibition.
authors.affiliation: Agroprocessing and Natural Products Division, National Institute for Interdisciplinary Science and Technology (CSIR), Thiruvananthapuram, Kerala, India.
authors.forename: P C
authors.initials: PC
authors.lastname: Lekshmi
authors.forename: Ranjith
authors.initials: R
authors.lastname: Arimboor
authors.forename: P S
authors.initials: PS
authors.lastname: Indulekha
authors.forename: A Nirmala
authors.initials: AN
authors.lastname: Menon
mesh_terms: D020909:Acarbose / Q000494:pharmacology; D030024:Curcuma / Q000737:chemistry*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000201:enzymology / Q000378:metabolism; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D020834:Ethnopharmacology; D065089:Glycoside Hydrolase Inhibitors; D006358:Hot Temperature; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology*; D007194:India; D007659:Ketones / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology; D007700:Kinetics; D008515:Medicine, Ayurvedic; D009822:Oils, Volatile / Q000737:chemistry / Q000494:pharmacology*; D027343:Rhizome / Q000737:chemistry; D012717:Sesquiterpenes / Q000032:analysis / Q000302:isolation & purification / Q000494:pharmacology; D000516:alpha-Amylases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000520:alpha-Glucosidases / Q000378:metabolism
chemical_list: D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D007004:Hypoglycemic Agents; D007659:Ketones; D009822:Oils, Volatile; D012717:Sesquiterpenes; C078098:ar-turmerone; D000516:alpha-Amylases; D000520:alpha-Glucosidases; D020909:Acarbose