title: Lipocalin-2: Response to a Progressive Treadmill Protocol in Obese and Normal-weight Men.
abstract: OBJECTIVE
  Lipocalin-2 (Lcn2), a newer adipocyte-secreted acute phase protein, was recently reported to be correlated with potential effects on obesity and inflammation. The reaction of this protein to progressive exercise has not been evaluated yet. This study was designed to compare the serum Lcn2 and high-sensitivity C-reactive protein (hs-CRP) levels after participating in an acute bout of treadmill protocol in obese and normal-weight men.
  
  
  METHODS
  NINE OBESE (AGED: 43.2±4.6 yrs and body mass index (BMI): 31.4±1.6 kg/m(2)) and 9 normal-weight (aged: 42.9±4.4 yrs and BMI: 23.03±1.7 kg/m(2); mean ± SD) sedentary men selected randomly from volunteers performed a single bout of exercise according to the treadmill Bruce protocol.
  
  
  RESULTS
  Before the exercise, Lcn2 level was higher in obese than normal-weight individuals (P<0.05). A significant increase in Lcn2, hs-CRP, white blood cells (WBC) and insulin resistance index was observed after the exercise in both groups (P<0.05). The level of Lcn2, hs-CRP and WBC increase was more significant in obese individuals than normal-weight subjects after the exercise (P<0.05).
  
  
  CONCLUSIONS
  It seems that the levels of Lcn2 and other inflammatory markers elevated in obese and normal-weight men after participating in an exhaustive progressive exercise. These changes in obese men were considerable.
authors.affiliation: Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Guilan, Rasht, Iran.
authors.forename: Arsalan
authors.initials: A
authors.lastname: Damirchi
authors.forename: Farhad
authors.initials: F
authors.lastname: Rahmani-Nia
authors.forename: Javad
authors.initials: J
authors.lastname: Mehrabani