title: Double-outlet right ventricle and double septal defects in a Rhesus macaque (Macaca mulatta).
abstract: A 6-year-old male India-origin Rhesus macaque (Macaca mulatta) presented with thin body condition and muscular atrophy. Thoracic auscultation revealed a grade VI/VI pansystolic murmur bilaterally. Radiographs showed cardiomegaly with significant left atrial and biventricular enlargement, a dilated pulmonary artery, and hepatomegaly. Electrocardiogram revealed a normal sinus rhythm interspersed with ventricular bigeminy. Hematology showed mild polycythemia and prerenal azotemia. Necropsy demonstrated double-outlet right ventricle with a large subaortic ventricular septal defect, subpulmonary stenosis, small atrial septal defect, and right ventricular hypertrophy. The major histological finding was severe chronic passive hepatic congestion. Double-outlet right ventricle is a rare congenital heart disease, both in human beings and animals.
authors.affiliation: Department of Comparative Pathology, Tulane National Primate Research Center, 18733 Three River Road, Covington, LA 70433, USA. dliu1@tulane.edu
authors.forename: David X
authors.initials: DX
authors.lastname: Liu
authors.forename: Margaret H
authors.initials: MH
authors.lastname: Gilbert
authors.forename: Doty J
authors.initials: DJ
authors.lastname: Kempf
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Didier
mesh_terms: D000818:Animals; D006343:Heart Septal Defects / Q000000981:diagnostic imaging / Q000662:veterinary*; D006352:Heart Ventricles / Q000002:abnormalities* / Q000000981:diagnostic imaging; D008253:Macaca mulatta / Q000002:abnormalities*; D008297:Male; D011651:Pulmonary Artery / Q000002:abnormalities; D011859:Radiography