title: In vitro biological activities of the essential oil from the 'resurrection plant' Myrothamnus moschatus (Baillon) Niedenzu endemic to Madagascar.
abstract: The essential oil of the 'resurrection plant' Myrothamnus moschatus (Baillon) Niedenzu endemic to Madagascar, where it is used in traditional medicine, was investigated for the first time for some biological activities. GC-FID and GC-MS analyses revealed trans-pinocarveol (35.6%), pinocarvone (20.0%), β-selinene (8.5%) and perillyl acetate (6.0%) as the major essential oil constituents. The oil strongly inhibited MDA-MB 231 (human breast adenocarcinoma) cells, with an IC(50) of 15 µg mL(-1), and the growth of Candida albicans, with an inhibition diameter of 18 mm, while its antioxidant activity, measured by DPPH and ABTS assay, proved to be negligible.
authors.affiliation: Department of Environmental Biology, La Sapienza University, Rome, Italy.
authors.forename: Marcello
authors.initials: M
authors.lastname: Nicoletti
authors.forename: Filippo
authors.initials: F
authors.lastname: Maggi
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Papa
authors.forename: Sauro
authors.initials: S
authors.lastname: Vittori
authors.forename: Luana
authors.initials: L
authors.lastname: Quassinti
authors.forename: Massimo
authors.initials: M
authors.lastname: Bramucci
authors.forename: Giulio
authors.initials: G
authors.lastname: Lupidi
authors.forename: Dezemona
authors.initials: D
authors.lastname: Petrelli
authors.forename: Luca A
authors.initials: LA
authors.lastname: Vitali
authors.forename: Ermenegilde
authors.initials: E
authors.lastname: Ralaibia
authors.forename: Philippe
authors.initials: P
authors.lastname: Rasoanaivo
mesh_terms: D000890:Anti-Infective Agents / Q000302:isolation & purification / Q000494:pharmacology*; D000081008:Bicyclic Monoterpenes; D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D003603:Cytotoxins / Q000302:isolation & purification / Q000494:pharmacology*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D066298:In Vitro Techniques; D020128:Inhibitory Concentration 50; D008270:Madagascar; D019684:Magnoliopsida / Q000737:chemistry*; D016488:Medicine, African Traditional; D039821:Monoterpenes / Q000032:analysis; D009822:Oils, Volatile / Q000302:isolation & purification / Q000494:pharmacology*; D045787:Sesquiterpenes, Eudesmane; D013764:Tetrahydronaphthalenes / Q000032:analysis
chemical_list: D000890:Anti-Infective Agents; D000081008:Bicyclic Monoterpenes; D003603:Cytotoxins; D039821:Monoterpenes; D009822:Oils, Volatile; D045787:Sesquiterpenes, Eudesmane; D013764:Tetrahydronaphthalenes; C534320:6,6-dimethyl-2-methylenebicyclo(3.1.1)heptan-3-ol; C087920:beta-selinene