title: Newly diagnosed acute lymphoblastic leukemia in China (I): abnormal genetic patterns in 1346 childhood and adult cases and their comparison with the reports from Western countries.
abstract: It has been generally acknowledged that the diagnosis, treatment and prognosis evaluation of leukemia largely rely on an adequate identification of genetic abnormalities. A systemic analysis of genetic aberrations was performed in a cohort of 1346 patients with newly diagnosed acute lymphoblastic leukemia (ALL) in China. The pediatric patients had higher incidence of hyperdiploidy and t(12;21) (p13;q22)/ETV6-RUNX1 than adults (P<0.0001); in contrast, the occurrence of Ph and Ik6 variant of IKZF1 gene was much more frequent in adult patients (all P<0.0001). In B-ALL, the existence of Ik6 and that of BCR-ABL were statistically correlated (P<0.0001). In comparison with Western cohorts, the incidence of t(9;22) (q34;q11)/BCR-ABL (14.60%) in B-ALL and HOX11 expression in T-ALL (25.24%) seemed to be much higher in our group, while the incidence of t(12;21) (p13;q22)/ETV6-RUNX1 (15.34%) seemed to be lower in Chinese pediatric patients. The occurrence of hyperdiploidy was much lower either in pediatric (10.61% vs 20-38%) or adult patients (2.36% vs 6.77-12%) in our study than in Western reports. In addition, the frequencies of HOX11L2 in adult patients were much higher in our cohort than in Western countries (20.69% vs 4-11%). In general, it seems that Chinese ALL patients bear more adverse prognostic factors than their Western counterparts do.
authors.affiliation: State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital, affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China.
authors.forename: B
authors.initials: B
authors.lastname: Chen
authors.forename: Y-Y
authors.initials: YY
authors.lastname: Wang
authors.forename: Y
authors.initials: Y
authors.lastname: Shen
authors.forename: W-N
authors.initials: WN
authors.lastname: Zhang
authors.forename: H-Y
authors.initials: HY
authors.lastname: He
authors.forename: Y-M
authors.initials: YM
authors.lastname: Zhu
authors.forename: H-M
authors.initials: HM
authors.lastname: Chen
authors.forename: C-H
authors.initials: CH
authors.lastname: Gu
authors.forename: X
authors.initials: X
authors.lastname: Fan
authors.forename: J-M
authors.initials: JM
authors.lastname: Chen
authors.forename: Q
authors.initials: Q
authors.lastname: Cao
authors.forename: G
authors.initials: G
authors.lastname: Yang
authors.forename: C-L
authors.initials: CL
authors.lastname: Jiang
authors.forename: X-Q
authors.initials: XQ
authors.lastname: Weng
authors.forename: X-X
authors.initials: XX
authors.lastname: Zhang
authors.forename: S-M
authors.initials: SM
authors.lastname: Xiong
authors.forename: Z-X
authors.initials: ZX
authors.lastname: Shen
authors.forename: H
authors.initials: H
authors.lastname: Jiang
authors.forename: L-J
authors.initials: LJ
authors.lastname: Gu
authors.forename: Z
authors.initials: Z
authors.lastname: Chen
authors.forename: J-Q
authors.initials: JQ
authors.lastname: Mi
authors.forename: S-J
authors.initials: SJ
authors.lastname: Chen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000235:genetics* / Q000378:metabolism*; D002648:Child; D002681:China; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D015331:Cohort Studies; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis* / Q000235:genetics* / Q000378:metabolism; D011379:Prognosis; D015996:Survival Rate; D019366:Western World; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor