title: Approaches for developing novel microtubule targeting agents (MTAs) for therapeutic exploitation.
abstract: The microtubule (MT) represents a highly validated target for therapy. Insights into the complex nature of the dynamic microtubule physiology will provide the basis for developing novel microtubule targeting agents with enhanced efficacy and minimised toxicity. In this article, with an emphasis on translational applications, we have summarised relevant aspects of tubulin physiology in the context of developing MT binding agents as therapeutic agents. Case studies were included to illustrate therapeutic developments in prostate cancer and current strategies to discover novel agents or targets for therapy.
authors.affiliation: Beatson Institute for Cancer Research and University of Glasgow, Glasgow, Scotland, U.K. h.leung@beatson.gla.ac.uk
authors.forename: Aswini
authors.initials: A
authors.lastname: Krishnan
authors.forename: James
authors.initials: J
authors.lastname: Wilson
authors.forename: Hing Y
authors.initials: HY
authors.lastname: Leung
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008870:Microtubules / Q000187:drug effects* / Q000378:metabolism; D057285:Precision Medicine; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000378:metabolism; D015398:Signal Transduction; D014404:Tubulin / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D014404:Tubulin