title: Selective laser-induced hyperthermia for the treatment of spontaneous tumors in dogs.
abstract: Indocyanine green (ICG), with spectral absorption at 800-810 nm, is a chromophore that strongly absorbs and converts near-infrared laser energy into thermal energy. By directly injecting ICG into a tumor, selective tumor hyperthermia during laser irradiation occurs. In this study, 4 dogs with spontaneous tumors were injected in situ with a 0.25% wt/vol ICG solution and immediately irradiated with 810 nm laser energy. Thermal data were collected from multiple thermocouples placed within the tumor and tumor response was recorded. Tissue heating to ≥ 42°C was observed in all tumors. One dog had a complete remission, one dog had stable disease for 12 weeks, and the other 2 dogs developed progressive disease shortly after treatment. Results from this study demonstrate that chromophore-enhanced laser-induced hyperthermia can effectively and selectively heat canine tumors. However, tumor size and pigmentation of overlying skin are potentially limiting factors to the success of this novel c ancer treatment.
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater, OK, USA and the Department of Physics and Engineering (WRC), University of Central Oklahoma, Edmond, OK, USA.
authors.forename: Michael D
authors.initials: MD
authors.lastname: Lucroy
authors.forename: Wei R
authors.initials: WR
authors.lastname: Chen
authors.forename: Tisha D
authors.initials: TD
authors.lastname: Ridgway
authors.forename: Russell G
authors.initials: RG
authors.lastname: Higbee
authors.forename: Kenneth E
authors.initials: KE
authors.lastname: Bartels