title: [Metabolic engineering strategies for carboxylic acids production by Saccharomyces cerevisiae---a review].
abstract: Carboxylatic acids have been widely used in food, pharmaceutical and chemical industries. As a eukaryotic model organism, Saccharomyces cerevisiae is thought as cell factory to produce organic acids through manipulating metabolic pathway. In this review, we addressed the metabolic engineering strategies to construct a high titer route converting pyruvate to target carboxylate, and to explore how to divert the carbon flux to desired product from ethanol. Furthermore, we also discussed the mechanisms for carboxylate transport and energy involved in. Finally, the relevant strategies for development in future are proposed.
authors.affiliation: State Key Laboratory of Food Science and Technology, Ministry of Education, Jiangnan University, Wuxi 214122, China. xuguoqiang@jiangnan.edu.cn
authors.forename: Guoqiang
authors.initials: G
authors.lastname: Xu
authors.forename: Liming
authors.initials: L
authors.lastname: Liu
authors.forename: Jian
authors.initials: J
authors.lastname: Chen
mesh_terms: D002264:Carboxylic Acids / Q000378:metabolism*; D000431:Ethanol / Q000378:metabolism; D005285:Fermentation; D060847:Metabolic Engineering; D019289:Pyruvic Acid / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000378:metabolism*
chemical_list: D002264:Carboxylic Acids; D000431:Ethanol; D019289:Pyruvic Acid