title: [Effect of PTH on bone structural properties].
abstract: Once-daily administration of parathyroid hormone (PTH) causes increased bone formation and bone mass. Both the anabolic and resorptive actions can be considered in the context of the anabolic window, a period of time during which PTH affects bone formation to a greater extent than it stimulates bone resorption. PTH appears to increase bone strength by increasing bone volume, number and connectivity of bone trabeculae, as well as by transformation from rod-like structure to plate-like structure. The change of cortical bone strength is complicated due to the increase of cortical thickness associated with increase in cortical porosity. The combination and sequential therapies with anti-resorptive agents are investigating from the view point of the effect of bone quality and bone strength.
authors.affiliation: Division of Radiology, Naasaki University Hospital, Japan.
authors.forename: Masako
authors.initials: M
authors.lastname: Ito
mesh_terms: D000818:Animals; D050071:Bone Density Conservation Agents / Q000008:administration & dosage; D001862:Bone Resorption / Q000139:chemically induced / Q000517:prevention & control; D001842:Bone and Bones / Q000378:metabolism* / Q000648:ultrastructure*; D004359:Drug Therapy, Combination; D006801:Humans; D010012:Osteogenesis / Q000187:drug effects; D010024:Osteoporosis / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D010281:Parathyroid Hormone / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D051381:Rats; D013997:Time Factors
chemical_list: D050071:Bone Density Conservation Agents; D010281:Parathyroid Hormone