title: Iron deficiency anemia in children presenting with lymphoreticular malignancies and the effect of induction therapy.
abstract: There is scant information regarding iron deficiency in children with malignant disorders. Serum iron status of children with lymphoreticular malignancies (LRMs) at onset and at the end of induction therapy, compared to the normal population, was evaluated. Prospective cohort study conducted between July 2002 and March 2004. Previously untreated children recently diagnosed with LRM were studied. Age-matched controls were enrolled from follow-up and growth monitoring clinics. Hematological (complete blood counts and red cell indices) parameters and markers of iron status (serum iron, serum ferritin, total iron binding capacity) were estimated at presentation and at the end of remission induction therapy, that is, 5 weeks after initial evaluation. Bone marrow iron store were only assessed in cases. Thirty-five children (31 with acute lymphoid leukemia, 2 with acute myeloid leukemia, and 2 with non-Hodgkin lymphoma; 27 boys and 8 girls; 2 to 12 years of age) were evaluated in the study cohort. Anemia was documented in 80% of children with LRM. Iron deficiency was an important etiological factor. In the majority of cases therapy resulted in significant improvement towards normalization of deranged hematological parameters. This phenomenon could be attributed to enhanced quantity and quality of erythropoietic activity and red cell transfusions. The observation suggests that therapeutic iron supplements are not indicated in the majority of children on therapy for malignant disorders. Various hematological and body iron status parameters should be assessed on a case-by-case basis.
authors.affiliation: Division of Pediatric-Hematology-Oncology, Advanced Pediatric Center, Postgraduate Institute of Medical Education and Research, Chandigarh, India. drbhanu04@yahoo.co.in
authors.forename: Bhanu Kiran
authors.initials: BK
authors.lastname: Bhakhri
authors.forename: Pankaj C
authors.initials: PC
authors.lastname: Vaidya
authors.forename: Amita
authors.initials: A
authors.lastname: Trehan
authors.forename: R K
authors.initials: RK
authors.lastname: Marwaha
authors.forename: G
authors.initials: G
authors.lastname: Garewal
mesh_terms: D018798:Anemia, Iron-Deficiency / Q000097:blood / Q000150:complications / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006801:Humans; D060828:Induction Chemotherapy; D015470:Leukemia, Myeloid, Acute / Q000097:blood / Q000150:complications / Q000628:therapy*; D008223:Lymphoma / Q000097:blood / Q000150:complications / Q000628:therapy*; D008228:Lymphoma, Non-Hodgkin / Q000097:blood / Q000150:complications / Q000628:therapy*; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood / Q000150:complications / Q000628:therapy*; D011446:Prospective Studies; D012074:Remission Induction