title: Resveratrol: Antioxidant activity and induction of fetal hemoglobin             in erythroid cells from normal donors and β-thalassemia patients.
abstract: Thalassemia and sickle-cell anemia (SCA) present a major public health problem             in countries where the number of carriers and affected individuals is high. As             a result of the abnormalities in hemoglobin production, cells of thalassemia and             SCA patients exhibit oxidative stress, which ultimately is responsible for the             chronic anemia observed. Therefore, identification of compounds exhibiting both             antioxidant and hemoglobin-inducing activities is highly needed. Our results demonstrate             resveratrol to be such a compound. This was shown both in the human K562 cell             line, as well as in erythroid precursors derived from normal donors and β-thalassemia             patients. Resveratrol was shown to exhibit antioxidant activity and to stimulate             the expression of the γ-globin genes and the accumulation of fetal hemoglobin             (HbF). To the best of our knowledge, this is the first report pointing to such             a double effect of resveratrol. Since this natural product is already marketed             as an antioxidant, future investigations should concentrate on demonstrating its             potential to augment HbF production in experimental animal models (e.g., thalassemia             and SCA mice) as well as in patients. We believe that the potential of clinical             use of resveratrol as an antioxidant and HbF stimulator may offer a simple and             inexpensive treatment to patients.
authors.affiliation: Department of Hematology, Hadassah-Hebrew University Medical                     Center, Jerusalem, Israel.
authors.forename: Eitan
authors.initials: E
authors.lastname: Fibach
authors.forename: Eugenia
authors.initials: E
authors.lastname: Prus
authors.forename: Nicoletta
authors.initials: N
authors.lastname: Bianchi
authors.forename: Cristina
authors.initials: C
authors.lastname: Zuccato
authors.forename: Giulia
authors.initials: G
authors.lastname: Breveglieri
authors.forename: Francesca
authors.initials: F
authors.lastname: Salvatori
authors.forename: Alessia
authors.initials: A
authors.lastname: Finotti
authors.forename: Michele
authors.initials: M
authors.lastname: Lipucci di Paola
authors.forename: Eleonora
authors.initials: E
authors.lastname: Brognara
authors.forename: Ilaria
authors.initials: I
authors.lastname: Lampronti
authors.forename: Monica
authors.initials: M
authors.lastname: Borgatti
authors.forename: Roberto
authors.initials: R
authors.lastname: Gambari
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D041905:Erythroid Cells / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology*; D015672:Erythroid Precursor Cells / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D005319:Fetal Hemoglobin / Q000235:genetics* / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D020014:K562 Cells; D010084:Oxidation-Reduction / Q000187:drug effects; D011401:Promoter Regions, Genetic / Q000235:genetics; D014176:Protein Biosynthesis / Q000187:drug effects; D040901:Proteomics; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D000077185:Resveratrol; D013267:Stilbenes / Q000737:chemistry / Q000494:pharmacology*; D014019:Tissue Donors; D014158:Transcription, Genetic / Q000187:drug effects; D055544:beta-Globins / Q000235:genetics; D017086:beta-Thalassemia / Q000473:pathology*; D055545:gamma-Globins / Q000235:genetics
chemical_list: D000975:Antioxidants; D012333:RNA, Messenger; D017382:Reactive Oxygen Species; D013267:Stilbenes; D055544:beta-Globins; D055545:gamma-Globins; D005319:Fetal Hemoglobin; D000077185:Resveratrol