title: Advancement in the research on vascular endothelial growth inhibitor (VEGI).
abstract: Vascular endothelial growth inhibitor (VEGI), also known as tumor necrosis factor superfamily member 15 or TNF ligand-related molecule 1, is identified as one kind of antiangiogenic cytokine that belongs to the tumor necrosis factor superfamily. VEGI includes three isoforms: VEGI-174, VEGI-192, and VEGI-251. VEGI can activate multiple signaling pathways including nuclear factor-kappaB, c-Jun N-terminal kinase, and p38 mitogen-activated protein kinase. Moreover, it suppresses endothelial cell proliferation, angiopoiesis, and tumor growth. Genetic engineering techniques have been used to produce recombinant human vascular endothelial growth inhibitor, and great progress has been made in its application for curing cancer. VEGI could serve as a potential target in the development of angiogenesis-based cancer therapy, and this paper briefly summarizes the progress of the research on VEGI.
authors.affiliation: College of Life Science, Henan Normal University, No. 46, Construction East Road, Xinxiang, 453007, Henan, China.
authors.forename: Lijiao
authors.initials: L
authors.lastname: Duan
authors.forename: Ganggang
authors.initials: G
authors.lastname: Yang
authors.forename: Ruigang
authors.initials: R
authors.lastname: Zhang
authors.forename: Lijuan
authors.initials: L
authors.lastname: Feng
authors.forename: Cunshuan
authors.initials: C
authors.lastname: Xu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D042783:Endothelial Cells / Q000187:drug effects / Q000276:immunology*; D005818:Genetic Engineering; D006131:Growth Inhibitors / Q000627:therapeutic use*; D006801:Humans; D009369:Neoplasms / Q000098:blood supply / Q000150:complications / Q000188:drug therapy*; D009389:Neovascularization, Pathologic / Q000188:drug therapy* / Q000209:etiology; D020033:Protein Isoforms / Q000235:genetics; D015398:Signal Transduction; D053380:Tumor Necrosis Factor Ligand Superfamily Member 15 / Q000235:genetics / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D006131:Growth Inhibitors; D020033:Protein Isoforms; C117026:TNFSF15 protein, human; D053380:Tumor Necrosis Factor Ligand Superfamily Member 15