title: [Peptidergic modulation of the hippocampus synaptic activity].
abstract: Effects of two newly synthesized nootropic and anxiolytic dipeptides: Noopept and Selank on inhibitory synaptic transmission in hippocampal CA1 pyramidal cells were investigated using patch-clamp technique in whole-cell configuration. Bath application of Noopept (1 microM) or Selank (2 microM) significantly increased the frequency of spike-dependent spontaneous m1PSCs, whereas spike-independent mlPSCs remained unchanged. It was suggested that both peptides mediated their effect sue to activation of inhibitory interneurons terminating on CA1 pyramidal cells. Results of current clamp recording of inhibitory interneurons residing in stratum radiatum confirmed this suggestion, at least for Noonent.
authors.forename: V G
authors.initials: VG
authors.lastname: Skrebitskiĭ
authors.forename: R V
authors.initials: RV
authors.lastname: Kondratenko
authors.forename: I S
authors.initials: IS
authors.lastname: Povarov
authors.forename: V I
authors.initials: VI
authors.lastname: Dereviagin
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D056547:CA1 Region, Hippocampal / Q000187:drug effects / Q000502:physiology; D004151:Dipeptides / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D053444:Inhibitory Postsynaptic Potentials / Q000187:drug effects; D007395:Interneurons / Q000187:drug effects; D008564:Membrane Potentials / Q000187:drug effects; D018697:Nootropic Agents / Q000494:pharmacology*; D009842:Oligopeptides / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D014151:Anti-Anxiety Agents; D004151:Dipeptides; D018697:Nootropic Agents; D009842:Oligopeptides; C103871:ethyl phenylacetyl-Pro-Gly; C100827:TP 7