title: The synthesis of pennogenin 3-O-β-D-glucopyranosyl-(1 → 3)-[α-L-rhamnopyranosyl-(1 → 2)]-β-D-glucopyranoside.
abstract: Pennogenin 3-O-β-D-glucopyranosyl-(1 → 3)-[α-L-rhamnopyranosyl-(1 → 2)]-β-D-glucopyranoside, a monodesmosidic saponin isolated from Paris polyphylla Smith var. yunnanensis with promised antitumor activities, was firstly synthesized from glucoside thiol via nine steps and with 27% overall yield.
authors.affiliation: Key Laboratory of Drug Targeting and Drug Delivery Systems of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu 610041, China.
authors.forename: Xin-Feng
authors.initials: XF
authors.lastname: Luo
authors.forename: Fan
authors.initials: F
authors.lastname: Lei
authors.forename: Yi
authors.initials: Y
authors.lastname: He
authors.forename: Shu-Chen
authors.initials: SC
authors.lastname: Pei
authors.forename: Li
authors.initials: L
authors.lastname: Hai
authors.forename: Shan
authors.initials: S
authors.lastname: Qian
authors.forename: Yong
authors.initials: Y
authors.lastname: Wu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D019668:Liliaceae / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D027343:Rhizome / Q000737:chemistry; D012503:Saponins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013237:Stereoisomerism; D013256:Steroids / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D012503:Saponins; D013256:Steroids; C571607:pennogenin-3-O-beta-D-glucopyranosyl-(1-3)-(alpha-L-rhamnopyranosyl-(1-2))-beta-D-glucopyranoside