title: Sesquiterpenes and other constituents from Dendranthema zawadskii var. latilobum.
abstract: Six new germacranolides, zawadskinolides A-F (1-6), and a new eudesmane glucoside, chrysantiloboside (7) were isolated from the aerial parts of Dendranthema zawadskii var. latilobum, along with thirteen known constituents. Their structures were elucidated by means of spectroscopic evidence. Bioassay showed that flavonoids such as apigenin (9), (-)-eriodictyol (10) and nepetin (12), as well as the sesquiterpene lactone, zawadskinolide F (6), inhibited nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophage cells with IC50 values of 66.15, 132.55, 35.44, and 91.32 μM, respectively.
authors.affiliation: Natural Products Research Institute and College of Pharmacy, Seoul National University, Seoul, Korea.
authors.forename: Hyun Jung
authors.initials: HJ
authors.lastname: Shin
authors.forename: So Young
authors.initials: SY
authors.lastname: Lee
authors.forename: Ju Sun
authors.initials: JS
authors.lastname: Kim
authors.forename: Sanghyun
authors.initials: S
authors.lastname: Lee
authors.forename: Ran Joo
authors.initials: RJ
authors.lastname: Choi
authors.forename: Ha Sook
authors.initials: HS
authors.lastname: Chung
authors.forename: Yeong Shik
authors.initials: YS
authors.lastname: Kim
authors.forename: Sam Sik
authors.initials: SS
authors.lastname: Kang
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D031202:Chrysanthemum / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D008070:Lipopolysaccharides / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D009569:Nitric Oxide / Q000037:antagonists & inhibitors; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D012717:Sesquiterpenes / Q000737:chemistry* / Q000494:pharmacology*; D045787:Sesquiterpenes, Eudesmane / Q000737:chemistry / Q000494:pharmacology; D045788:Sesquiterpenes, Germacrane / Q000737:chemistry / Q000494:pharmacology; D013057:Spectrum Analysis / Q000379:methods
chemical_list: D005419:Flavonoids; D008070:Lipopolysaccharides; D010936:Plant Extracts; D012717:Sesquiterpenes; D045787:Sesquiterpenes, Eudesmane; D045788:Sesquiterpenes, Germacrane; C432449:germacranolide; D009569:Nitric Oxide; C015872:eudesmane