title: The therapeutic potential of metal-based antimalarial agents: implications for the mechanism of action.
abstract: Despite recent encouraging advances against the disease, malaria remains a major public health problem affecting almost half a billion people and killing almost a million per annum. Due to a short arsenal of efficient antimalarial agents and the frequent appearance of resistance to the drugs in current use, which consequently reduce our means to treat patients, there is a very urgent and continuous need to develop new compounds. This perspective outlines a unique strategy for that purpose through the development of metal-based antimalarial agents. The examples presented here illustrate an attractive alternative to classical drugs.
authors.affiliation: Université Lille 1, Unité de Glycobiologie Structurale et Fonctionnelle, 59650 Villeneuve d'Ascq, France. christophe.biot@univ-lille1.fr
authors.forename: Christophe
authors.initials: C
authors.lastname: Biot
authors.forename: William
authors.initials: W
authors.lastname: Castro
authors.forename: Cyrille Y
authors.initials: CY
authors.lastname: Botté
authors.forename: Maribel
authors.initials: M
authors.lastname: Navarro
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry* / Q000494:pharmacology*; D006801:Humans; D008018:Life Cycle Stages / Q000187:drug effects; D008288:Malaria / Q000469:parasitology; D008670:Metals / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology; D010961:Plasmodium / Q000187:drug effects*
chemical_list: D000962:Antimalarials; D008670:Metals; D009942:Organometallic Compounds