title: Very early recurrence of anti-Phospholipase A2 receptor-positive membranous nephropathy after transplantation.
abstract: Membranous nephropathy is a common cause of adult nephrotic syndrome, with recent evidence suggesting that 70% of idiopathic disease is associated with anti-Phospholipase A(2)  receptor autoantibodies. We describe a 63-year-old man with membranous nephropathy who underwent a kidney transplant and developed recurrent membranous nephropathy with fine granular co-localization of Phospholipase A(2)  receptor and IgG evident on transplant biopsy on day 6 and elevated circulating levels of serum anti-Phospholipase A(2)  receptor autoantibody that declined over time in conjunction with improvement in the serum creatinine and urinary protein. This is a very early case of Phospholipase A(2)  receptor-associated recurrent membranous nephropathy with circulating anti-Phospholipase A(2)  receptor autoantibody, which supports the emerging evidence that idiopathic membranous nephropathy is an autoimmune disease.
authors.affiliation: Department of Medicine, University of Iowa, Iowa City, IA, USA. christopher-blosser@uowa.edu
authors.forename: C D
authors.initials: CD
authors.lastname: Blosser
authors.forename: R
authors.initials: R
authors.lastname: Ayalon
authors.forename: R
authors.initials: R
authors.lastname: Nair
authors.forename: C
authors.initials: C
authors.lastname: Thomas
authors.forename: L H
authors.initials: LH
authors.lastname: Beck
mesh_terms: D001323:Autoantibodies / Q000276:immunology*; D015433:Glomerulonephritis, Membranous / Q000276:immunology / Q000473:pathology* / Q000601:surgery; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D054507:Receptors, Phospholipase A2 / Q000276:immunology*; D012008:Recurrence
chemical_list: D001323:Autoantibodies; D054507:Receptors, Phospholipase A2