title: Toxicity assessment of zebrafish following exposure to CdTe QDs.
abstract: CdTe quantum dots (QDs) are nanocrystals of unique composition and properties that have found many new commercial applications; therefore, their potential toxicity to aquatic organisms has become a hot research topic. The lab study was performed to determine the developmental and behavioral toxicities to zebrafish under continuous exposure to low concentrations of CdTe QDs (1-400 nM) coated with thioglycolic acid (TGA). The results show: (1) the 120 h LC(50) of 185.9 nM, (2) the lower hatch rate and body length, more malformations, and less heart beat and swimming speed of the exposed zebrafish, (3) the brief burst and a higher basal swimming rate of the exposed zebrafish larvae during a rapid transition from light-to-dark, and (4) the vascular hyperplasia, vascular bifurcation, vascular crossing and turbulence of the exposed FLI-1 transgenic zebrafish larvae.
authors.affiliation: State Environmental Protection Key Laboratory of Environmental Risk Assessment and Control on Chemical Process, East China University of Science and Technology, Shanghai 200237, PR China. wzhang@ecust.edu.cn
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Kuangfei
authors.initials: K
authors.lastname: Lin
authors.forename: Youna
authors.initials: Y
authors.lastname: Miao
authors.forename: Qiaoxiang
authors.initials: Q
authors.lastname: Dong
authors.forename: Changjiang
authors.initials: C
authors.lastname: Huang
authors.forename: Huili
authors.initials: H
authors.lastname: Wang
authors.forename: Meijin
authors.initials: M
authors.lastname: Guo
authors.forename: Xinhong
authors.initials: X
authors.lastname: Cui
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000473:pathology; D000818:Animals; D001808:Blood Vessels / Q000187:drug effects / Q000254:growth & development / Q000502:physiology; D019187:Cadmium Compounds / Q000633:toxicity*; D004625:Embryo, Nonmammalian; D005260:Female; D006128:Growth / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D007814:Larva; D008297:Male; D017440:Photoperiod; D045663:Quantum Dots; D012098:Reproduction; D013550:Swimming / Q000502:physiology; D013691:Tellurium / Q000633:toxicity*; D015027:Zebrafish / Q000502:physiology*
chemical_list: D019187:Cadmium Compounds; D013691:Tellurium; C028337:cadmium telluride