title: [Role of immune alterations induced by papillomavirus in development of cervical cancer ].
abstract: Squamous cell cancer of the uterine cervix is associated with a high morbidity and mortality worldwide and in Belgium. The link between cervical cancer and HPV has generated, in recent years, a great interest for studies aiming to better understand the role of the immune system in the control of these infections and for the development of prophylactic anti-HPV vaccines. The purpose of this work was to analyse the immune co-factors implicated in the promotion of the neoplastic process. We have shown that both virus-induced immune alterations and squamous metaplasia in the transformation zone of the uterine cervix play a role to create an immunotolerogenic microenvironment during the cervical carcinogenesis.
authors.affiliation: Laboratoire de Pathologie Expérimentale, GIGA-Cancer-Université de Liège-CHU Sart Tilman.
authors.forename: P
authors.initials: P
authors.lastname: Delvenne
mesh_terms: D000328:Adult; D002471:Cell Transformation, Neoplastic / Q000276:immunology*; D005260:Female; D006801:Humans; D018307:Neoplasms, Squamous Cell / Q000276:immunology* / Q000473:pathology / Q000821:virology*; D027383:Papillomaviridae / Q000276:immunology* / Q000648:ultrastructure; D002583:Uterine Cervical Neoplasms / Q000276:immunology* / Q000473:pathology / Q000821:virology*