title: [Update and perspectives of anabolic therapies for osteoporosis].
abstract: Daily subcutaneous self-injection and weekly subcutaneous injection formulas of teriparatide are available as anabolic agents in Japan. These injection formulas are expected to serve as a new treatment choice for high fracture-risk patients with osteoporosis. In addition, studies using new anabolic agents such as PTHrP, calcilytics, and Wnt inhibitor antagonists/antibodies are under way to develop new anabolic agents. These agents may become new treatment drugs for osteoporotic patients especially with low bone turnover.
authors.affiliation: Division of Endocrinology and Metabolism, The University of Tokushima Hospital, Japan.
authors.forename: Itsuro
authors.initials: I
authors.lastname: Endo
authors.forename: Toshio
authors.initials: T
authors.lastname: Matsumoto
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D045930:Anabolic Agents / Q000008:administration & dosage; D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D015519:Bone Density; D050071:Bone Density Conservation Agents / Q000008:administration & dosage*; D019485:Bone Morphogenetic Proteins / Q000276:immunology / Q000502:physiology; D005819:Genetic Markers / Q000276:immunology / Q000502:physiology; D006801:Humans; D007189:Indans / Q000627:therapeutic use; D007279:Injections, Subcutaneous; D010024:Osteoporosis / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D058866:Osteoporotic Fractures / Q000209:etiology / Q000517:prevention & control; D044162:Parathyroid Hormone-Related Protein / Q000008:administration & dosage; D010666:Phenylpropionates / Q000627:therapeutic use; D044169:Receptors, Calcium-Sensing / Q000037:antagonists & inhibitors; D019379:Teriparatide / Q000008:administration & dosage*; D060449:Wnt Signaling Pathway / Q000187:drug effects
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D045930:Anabolic Agents; D000911:Antibodies, Monoclonal; D050071:Bone Density Conservation Agents; D019485:Bone Morphogenetic Proteins; D005819:Genetic Markers; D007189:Indans; D044162:Parathyroid Hormone-Related Protein; D010666:Phenylpropionates; D044169:Receptors, Calcium-Sensing; C422903:SOST protein, human; D019379:Teriparatide; C561716:ronacaleret