title: CRDB: database of chemosensory receptor gene families in vertebrate.
abstract: Chemosensory receptors (CR) are crucial for animals to sense the environmental changes and survive on earth. The emergence of whole-genome sequences provides us an opportunity to identify the entire CR gene repertoires. To completely gain more insight into the evolution of CR genes in vertebrates, we identified the nearly all CR genes in 25 vertebrates using homology-based approaches. Among these CR gene repertoires, nearly half of them were identified for the first time in those previously uncharacterized species, such as the guinea pig, giant panda and elephant, etc. Consistent with previous findings, we found that the numbers of CR genes vary extensively among different species, suggesting an extreme form of 'birth-and-death' evolution. For the purpose of facilitating CR gene analysis, we constructed a database with the goals to provide a resource for CR genes annotation and a web tool for exploring their evolutionary patterns. Besides a search engine for the gene extraction from a specific chromosome region, an easy-to-use phylogenetic analysis tool was also provided to facilitate online phylogeny study of CR genes. Our work can provide a rigorous platform for further study on the evolution of CR genes in vertebrates.
authors.affiliation: Institute of Molecular Ecology and Evolution, iAIR, East China Normal University, Shanghai, China. ddong.ecnu@gmail.com
authors.forename: Dong
authors.initials: D
authors.lastname: Dong
authors.forename: Ke
authors.initials: K
authors.lastname: Jin
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Wu
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhong
mesh_terms: D000818:Animals; D002633:Chemotaxis; D057225:Data Mining / Q000379:methods; D016208:Databases, Factual; D016678:Genome; D006801:Humans; D020407:Internet; D008322:Mammals / Q000502:physiology; D005810:Multigene Family; D016133:Polymerase Chain Reaction; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism*; D018035:Receptors, Odorant / Q000737:chemistry; D016415:Sequence Alignment; D013045:Species Specificity; D014714:Vertebrates / Q000502:physiology*
chemical_list: D011506:Proteins; D018035:Receptors, Odorant