title: Hydroxyurea makes inflammation "just right"?
abstract: Hydroxyurea treatment of sickle cell mice improved their survival from pneumococcal pneumonia, counteracting the abnormally elevated inflammatory response and reducing invasion of bacteria into the bloodstream, through down regulation of E-selectin.
authors.affiliation: University of Illinois, USA.
authors.forename: Lewis L
authors.initials: LL
authors.lastname: Hsu
mesh_terms: D000755:Anemia, Sickle Cell / Q000188:drug therapy*; D000818:Animals; D019040:E-Selectin / Q000378:metabolism*; D005260:Female; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use*; D011018:Pneumonia, Pneumococcal / Q000517:prevention & control*
chemical_list: D019040:E-Selectin; D006918:Hydroxyurea