title: Effects of short-term sodium chlorate exposure on pigs.
abstract: The present study evaluated the effects of exposure to different doses of sodium chlorate in 10-week-old pigs. Twenty pigs were divided into four equal groups and treated with different doses of sodium chlorate: 0, 125, 250 and 500 mg kg-1 body weight per day via the drinking water for 7 consecutive days. The results showed a significant decrease (P < 0.05) in red blood cell and white blood cell counts, packed cell volume, haemoglobin, blood urea nitrogen (P < 0.001) and creatinine levels, and an increase in aspartate aminotransferase and alanine aminotransferase (P < 0.05) activities in swine administered sodium chlorate at a dose of 500 mg kg-1 body weight per day. The histopathological study revealed increased numbers of vacuoles in the convoluted tubules, tubular necrosis and degeneration of the renal tubular epithelial cells, depletion of nuclei and lobular necrosis of the liver in all pigs treated with sodium chlorate at 500 mg kg-1 body weight per day. Thus, 7-day administration of sodium chlorate at 500 mg kg-1 body weight per day to pigs affects the liver and kidney tissues as well as the haematologic and serum biochemical parameters.
authors.affiliation: Gyeongsang National University Engineering Research Institute, Department of Industrial Systems Engineering, Chinju, Korea.
authors.forename: Chun-Nam
authors.initials: CN
authors.lastname: Cha
authors.forename: Won-Chul
authors.initials: WC
authors.lastname: Jung
authors.forename: Hyunju
authors.initials: H
authors.lastname: Choi
authors.forename: Yeo Eun
authors.initials: YE
authors.lastname: Lee
authors.forename: Chang-Yeul
authors.initials: CY
authors.lastname: Yoo
authors.forename: Suk
authors.initials: S
authors.lastname: Kim
authors.forename: Hu-Jang
authors.initials: HJ
authors.lastname: Lee
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D002704:Chlorates / Q000008:administration & dosage / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D006540:Herbicides / Q000008:administration & dosage / Q000633:toxicity*; D016877:Oxidants / Q000008:administration & dosage / Q000633:toxicity*; D013552:Swine; D013553:Swine Diseases / Q000097:blood / Q000139:chemically induced*; D014867:Water / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D002704:Chlorates; D006540:Herbicides; D016877:Oxidants; D014867:Water; C032706:sodium chlorate