title: Serum beta2-microglobin is a predictor of prognosis in patients with upper aerodigestive tract NK/T-cell lymphoma.
abstract: Upper aerodigestive tract natural killer (NK)/T-cell lymphoma (UNKTL) is the most common type of extranodal NK/T-cell lymphoma, nasal type. Serum beta2-microglobulin (β2-M) was found to be a predictor in some subtypes of B-cell lymphoma. However, its prognostic significance in NK/T-cell lymphoma has never been explored. We retrospectively analyzed 82 patients newly diagnosed as UNKTL. Serum β2-M was detected prior to treatment in this series. Various statistical analyses were performed to evaluate the significance of the relevant clinical parameters. High serum β2-M level was calculated as ≥2.5 mg/L by the median value. The number of patients with serum β2-M ≥2.5 mg/L at diagnosis was 39 (47.6%) and 43 patients (52.4%) with β2-M <2.5 mg/L. Patients with high serum β2-M level at diagnosis seemed to have more adverse clinical features: B symptoms (p=0.007) and elevated LDH level (p<0.001), and high KPI score (p=0.002). Serum β2-M ≥2.5 mg/L was significantly associated with poor overall survival (5-year OS, 35.2% vs 73.6%; p=0.001) and progression-free survival (5-year PFS, 27.5% vs 55.9%; p=0.028). For patients with early stage, serum β2-M at diagnosis could also help to distinguish those with favorable outcomes from those with poor outcomes. In multivariate analysis, high serum β2-M level remained its prognostic impact on survival (OS: p=0.002; PFS: p=0.039), independent of the International Prognostic Index score. Our study suggested high serum β2-M was a novel predictor of prognosis in patients with UNKTL. A simply and regular way might be established to identify UNKTL patients of different risks at diagnosis.
authors.affiliation: State Key Laboratory of Oncology in Southern China, Department of Medical Oncology, Sun Yat-sen University Cancer Center, 651 Dong Feng RD East, Guangzhou, China. lzmlzmlzm@yahoo.com
authors.forename: Zhi-Ming
authors.initials: ZM
authors.lastname: Li
authors.forename: Ying-Jie
authors.initials: YJ
authors.lastname: Zhu
authors.forename: Jian
authors.initials: J
authors.lastname: Sun
authors.forename: Yi
authors.initials: Y
authors.lastname: Xia
authors.forename: Jia-Jia
authors.initials: JJ
authors.lastname: Huang
authors.forename: Ben-Yan
authors.initials: BY
authors.lastname: Zou
authors.forename: Tong-Yu
authors.initials: TY
authors.lastname: Lin
authors.forename: Hui-Qiang
authors.initials: HQ
authors.lastname: Huang
authors.forename: Wen-Qi
authors.initials: WQ
authors.lastname: Jiang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis / Q000097:blood / Q000502:physiology; D005260:Female; D006258:Head and Neck Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000401:mortality; D006801:Humans; D054391:Lymphoma, Extranodal NK-T-Cell / Q000097:blood / Q000175:diagnosis* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D055815:Young Adult; D001613:beta 2-Microglobulin / Q000032:analysis / Q000097:blood* / Q000502:physiology
chemical_list: D014408:Biomarkers, Tumor; D001613:beta 2-Microglobulin