title: Two new compounds from the fruits of Buddleja lindleyana with neuroprotective effect.
abstract: Two new triterpenoid glycosides, mimengosides H (1) and I (2), were isolated from the fruits of Buddleja lindleyana Fort. Their structures were determined by extensive spectroscopic methods. Neuroprotective effects of these isolates against 1-methyl-4-phenylpyridinium ion-induced neurotoxicity in PC12 cells were evaluated. Pretreatment with compound 1 had potential protective effect in a concentration range from 0.1 to 1 μmol l⁻¹.
authors.affiliation: Anhui University of Traditional Chinese Medicine, Hefei 230031, China. dlwu7375@sina.com.cn
authors.forename: De-Ling
authors.initials: DL
authors.lastname: Wu
authors.forename: Yang-Kui
authors.initials: YK
authors.lastname: Wang
authors.forename: Jing-Song
authors.initials: JS
authors.lastname: Liu
authors.forename: Xun-Cui
authors.initials: XC
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000818:Animals; D032861:Buddleja / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005638:Fruit / Q000737:chemistry; D006801:Humans; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D016716:PC12 Cells; D051381:Rats; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D004365:Drugs, Chinese Herbal; D018696:Neuroprotective Agents; D012503:Saponins; D014315:Triterpenes; C571640:mimengoside H; C571641:mimengoside I