title: How much does the amphioxus genome represent the ancestor of chordates?
abstract: One of the main motivations to study amphioxus is its potential for understanding the last common ancestor of chordates, which notably gave rise to the vertebrates. An important feature in this respect is the slow evolutionary rate that seems to have characterized the cephalochordate lineage, making amphioxus an interesting proxy for the chordate ancestor, as well as a key lineage to include in comparative studies. Whereas slow evolution was first noticed at the phenotypic level, it has also been described at the genomic level. Here, we examine whether the amphioxus genome is indeed a good proxy for the genome of the chordate ancestor, with a focus on protein-coding genes. We investigate genome features, such as synteny, gene duplication and gene loss, and contrast the amphioxus genome with those of other deuterostomes that are used in comparative studies, such as Ciona, Oikopleura and urchin.
authors.affiliation: Institute of Biology of the Ecole Normale Supérieure, Paris, France.
authors.forename: Alexandra
authors.initials: A
authors.lastname: Louis
authors.forename: Hugues
authors.initials: H
authors.lastname: Roest Crollius
authors.forename: Marc
authors.initials: M
authors.lastname: Robinson-Rechavi
mesh_terms: D000818:Animals; D043344:Chordata / Q000235:genetics*; D017124:Conserved Sequence / Q000235:genetics; D020131:Genes, Duplicate / Q000235:genetics; D016678:Genome / Q000235:genetics*; D010802:Phylogeny; D026801:Synteny / Q000235:genetics