title: Intensifying insulin therapy with insulin analog premixes: transitioning from basal insulin in type 2 diabetes.
abstract: Because of the progressive nature of type 2 diabetes, basal insulin alone may not be able to provide sufficient glycemic control over the long term, and thus insulin regimens will typically need to be intensified--especially for controlling postprandial glucose excursions. In patients with type 2 diabetes requiring more intensive intervention, insulin analog premix formulations can offer a simple, effective, and convenient option for tighter management of hyperglycemia in lieu of a traditional basal-bolus regimen.
authors.affiliation: Endocrine Associates of Long Island, P.C., Smithtown, New York 11787, USA. mshanikmd@yahoo.com
authors.forename: Michael H
authors.initials: MH
authors.lastname: Shanik
mesh_terms: D001786:Blood Glucose / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D007328:Insulin / Q000008:administration & dosage* / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D061267:Insulin Aspart / Q000008:administration & dosage; D000069057:Insulin Detemir; D061268:Insulin Lispro / Q000008:administration & dosage; D049528:Insulin, Long-Acting / Q000008:administration & dosage; D008297:Male; D008687:Metformin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D019518:Postprandial Period; D016032:Randomized Controlled Trials as Topic
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D007328:Insulin; D061267:Insulin Aspart; D000069057:Insulin Detemir; D061268:Insulin Lispro; D049528:Insulin, Long-Acting; D008687:Metformin; C517652:hemoglobin A1c protein, human