title: Copper-catalyzed C-H oxidation/cross-coupling of α-amino carbonyl compounds.
abstract: Keeping options open: the new and mild title reaction involving indoles selectively furnishes 1 and 2 with the aid of tert-butyl hydroperoxide (TBHP). The method represents the first example of a copper-catalyzed α arylation of α-amino carbonyl substrates leading to α-aryl α-imino and α-aryl α-oxo carbonyl compounds using a C-H oxidation strategy.
authors.affiliation: State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, China.
authors.forename: Ji-Cheng
authors.initials: JC
authors.lastname: Wu
authors.forename: Ren-Jie
authors.initials: RJ
authors.lastname: Song
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Wang
authors.forename: Xiao-Cheng
authors.initials: XC
authors.lastname: Huang
authors.forename: Ye-Xiang
authors.initials: YX
authors.lastname: Xie
authors.forename: Jin-Heng
authors.initials: JH
authors.lastname: Li
mesh_terms: D000588:Amines / Q000737:chemistry; D002244:Carbon / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry; D007211:Indoles / Q000737:chemistry; D007659:Ketones / Q000737:chemistry*; D010084:Oxidation-Reduction; D020122:tert-Butylhydroperoxide / Q000737:chemistry
chemical_list: D000588:Amines; D007211:Indoles; D007659:Ketones; D002244:Carbon; D003300:Copper; D006859:Hydrogen; C030374:indole; D020122:tert-Butylhydroperoxide