title: Functional neuroimaging of the 6-OHDA lesion rat model of Parkinson's disease.
abstract: We characterized the unilaterally 6-hydroxydopamine (6-OHDA)-lesioned rat, a well-known acute model of Parkinson's disease (PD), with [(18)F]-fluoro-2-deoxy-d-glucose (FDG) small-animal positron emission tomography (PET), which we compared with a drug-induced rotation behavioral test. In the 6-OHDA model, significant glucose hypometabolism was present in the primary motor cortex, substantia nigra, and pedunculopontine tegmental nucleus on the ipsilateral side. In contrast, neuronal activations were observed in the primary somatosensory cortex and ventral caudate-putamen area after lesioning. Correlation analysis revealed a significant relationship between the behavioral results and the degree of glucose metabolism impairment in the primary motor cortex, substantia nigra, and pedunculopontine tegmental nucleus. In addition, the pedunculopontine tegmental nucleus correlated significantly with the primary somatosensory cortex, the ventral caudate-putamen, the substantia nigra, and the primary motor cortex. Furthermore, the primary motor cortex also showed significant correlations with the substantia nigra. In conclusion, In vivo cerebral mapping of the 6-OHDA-lesioned rats using [(18)F]-FDG PET showed correspondence at the functional levels to the cortico-subcortical network impairment observed in PD patients.
authors.affiliation: Department of Biomedical Engineering, Hanyang University, Seoul, Republic of Korea.
authors.forename: Dong Pyo
authors.initials: DP
authors.lastname: Jang
authors.forename: Hoon-Ki
authors.initials: HK
authors.lastname: Min
authors.forename: Sang-Yoon
authors.initials: SY
authors.lastname: Lee
authors.forename: In Young
authors.initials: IY
authors.lastname: Kim
authors.forename: Hyung Woo
authors.initials: HW
authors.lastname: Park
authors.forename: Yong Hoon
authors.initials: YH
authors.lastname: Im
authors.forename: Sohee
authors.initials: S
authors.lastname: Lee
authors.forename: Jeongeun
authors.initials: J
authors.lastname: Sim
authors.forename: Young-Bo
authors.initials: YB
authors.lastname: Kim
authors.forename: Sun Ha
authors.initials: SH
authors.lastname: Paek
authors.forename: Zang-Hee
authors.initials: ZH
authors.lastname: Cho
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism; D059907:Functional Neuroimaging / Q000379:methods*; D008297:Male; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000000981:diagnostic imaging* / Q000378:metabolism; D016627:Oxidopamine / Q000633:toxicity*; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000000981:diagnostic imaging* / Q000378:metabolism; D011877:Radionuclide Imaging; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D016627:Oxidopamine