title: Fibrinogen polymorphisms associated with sporadic cerebral hemorrhage in a Chinese population.
abstract: Fibrinogen plays an important role in the intrinsic and extrinsic pathways of blood coagulation. This study investigated the association between common variants in the fibrinogen gene and the risk of developing sporadic cerebral hemorrhage (CH). We performed genotyping analyses for three single nucleotide polymorphisms (SNP) in the fibrinogen gene in a case-controlled study involving 195 patients with CH and 116 control participants; both groups were of southern Han-Chinese origin. Logistic regression analysis indicated that haplotypes ATA (rs1800790+rs1800787+rs6050), AA (rs1800790+rs6050) and TA (rs1800787+rs6050) could nearly double the risk of sporadic CH (odds ratio [OR]=1.738, 95% confidence interval [CI]: 1.103-2.740, p=0.017; adjusted OR=1.762, 95% CI: 1.042-2.982, p=0.035), although the three SNP were not associated with sporadic CH when analyzed separately. These findings indicate that rs1800790, rs1800787 and rs6050 polymorphisms may contribute to the etiology of sporadic CH in the Chinese population.
authors.affiliation: Department of Geriatrics, Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Zeng
authors.forename: Le
authors.initials: L
authors.lastname: Zhang
authors.forename: ZhiPing
authors.initials: Z
authors.lastname: Hu
authors.forename: QiDong
authors.initials: Q
authors.lastname: Yang
authors.forename: MingMing
authors.initials: M
authors.lastname: Ma
authors.forename: BaoQiong
authors.initials: B
authors.lastname: Liu
authors.forename: Jian
authors.initials: J
authors.lastname: Xia
authors.forename: HongWei
authors.initials: H
authors.lastname: Xu
authors.forename: Yunhai
authors.initials: Y
authors.lastname: Liu
authors.forename: XiaoPing
authors.initials: X
authors.lastname: Du
mesh_terms: D000368:Aged; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002543:Cerebral Hemorrhage / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics*; D002681:China / Q000453:epidemiology; D005260:Female; D005340:Fibrinogen / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D005340:Fibrinogen