title: [Eye and corticosteroid's use].
abstract: Most common side effects of systemic corticosteroids are posterior subcapsular cataract and glaucoma. There is no way to prevent corticosteroid-induced cataract. The risk of these complications varies (cataract 11 to 15%; glaucoma 12.8%), and it depends on the dose, duration of administration and terrain. The discontinuation of corticosteroid therapy is required in cases of uncontrolled glaucoma by hypotonic treatment. Long-term topical or general steroids prescription has to be done after an ophthalmological examination. Indications of ophthalmic general corticosteroids are acute orbital and ocular inflammations. affecting the middle and posterior segments of the eye, or sclera when topical treatment is ineffective. When administered topically, only 5% of the delivered dose is absorbed by the anterior segment, distribution is almost zero in the middle and posterior segments of the eye.
authors.affiliation: Assistance Publique-Hôpitaux de Paris, Hôtel-Dieu, université Paris Descartes, service de médecine interne, 75004 Paris, France.
authors.forename: Audrey
authors.initials: A
authors.lastname: Fel
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Aslangul
authors.forename: Claire
authors.initials: C
authors.lastname: Le Jeunne
mesh_terms: D000305:Adrenal Cortex Hormones / Q000009:adverse effects* / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002386:Cataract / Q000139:chemically induced*; D004305:Dose-Response Relationship, Drug; D009877:Endophthalmitis / Q000188:drug therapy*; D005901:Glaucoma / Q000139:chemically induced*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D007249:Inflammation / Q000188:drug therapy; D012307:Risk Factors
chemical_list: D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents