title: [Study on semi-synthetic transforming technology for the natural product of isocorydione].
abstract: Transforming technology for semi-synthesized isocorydione from the natural product ofisocorydine was studied. The factors affecting on the reaction yield were investigated. UV spectrophotometry was used to indicate the semi-synthesized yield of isocorydione. The optimum reaction conditions were determined as following: reacting for 12 h in the solution of sodium dihydrogen phosphate at pH 10, the temperature was 25 degrees C and the ratio of isocorydine to Fremy's radical was 1 : 2. Under the optimum conditions, the yield could reach up to 50.0%. The molecular structure of isocorydione was elucidated by X-ray single-crystal diffraction analysis for the first time.
authors.affiliation: School of Pharmay, Gansu College of Traditional Chinese Medicine, Lanzhou 730000, China.
authors.forename: Tian-Cai
authors.initials: TC
authors.lastname: Zhang
authors.forename: He-Lin
authors.initials: HL
authors.lastname: Ye
authors.forename: Jun-Xi
authors.initials: JX
authors.lastname: Liu
authors.forename: Duo-Long
authors.initials: DL
authors.lastname: Di
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000737:chemistry* / Q000302:isolation & purification; D001060:Aporphines / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification; D018360:Crystallography, X-Ray; D006863:Hydrogen-Ion Concentration; D015394:Molecular Structure; D009603:Nitroso Compounds; D010084:Oxidation-Reduction; D028101:Papaveraceae / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D013696:Temperature; D014961:X-Ray Diffraction
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D001060:Aporphines; D009603:Nitroso Compounds; C582232:isocorydione; C001259:Fremy's salt; C030168:isocorydine