title: Design, synthesis and antimicrobial evaluation of novel 2-aryl-thiazolidin-4-one derivatives.
abstract: Novel 2-arylthiazolidin-4-one derivatives (8a-q and 11) have been synthesized in good-to-excellent yields (70-96%) by one-pot three-component condensation-cyclization reaction of aromatic or aliphatic primary amines, aromatic aldehydes, and thioglycolic acid in polypropylene glycol at 110°C temperature. The in vitro antimicrobial activity of the synthesized 2-arylthiazolidin-4-ones was investigated against a panel of six pathogenic fungal strains, a Gram-positive and three Gram-negative bacteria. Results revealed that the compounds (8a-d) bearing 3-(4-(1H-imidazolylmethyl)phenyl)-substituent displayed significant antibacterial efficacy specifically against Klebsiella pneumoniae (minimum inhibitory concentration 12.5 μg/mL). In addition, some of the synthesized compounds have also shown antimicotic activity against Sporothrix schenckii, Trichophyton mentagrophytes, and Aspergillus fumigatus at the concentration of 50 μg/mL.
authors.affiliation: Department of Chemistry, University of Delhi, Delhi 110 007, India. mnathchemistry@gmail.com.
authors.forename: Davinder
authors.initials: D
authors.lastname: Prasad
authors.forename: Awanit
authors.initials: A
authors.lastname: Kumar
authors.forename: Praveen Kumar
authors.initials: PK
authors.lastname: Shukla
authors.forename: Mahendra
authors.initials: M
authors.lastname: Nath