title: Evidence-based effectiveness of vaccination against Mannheimia haemolytica, Pasteurella multocida, and Histophilus somni in feedlot cattle for mitigating the incidence and effect of bovine respiratory disease complex.
abstract: Bovine respiratory disease complex is the leading cause of morbidity and mortality in feedlot cattle. A number of vaccines against bacterial respiratory pathogens are commercially available and researchers have studied their impact on morbidity, mortality, and other disease outcome measures in feedlot cattle. A systematic review will provide veterinarians with a rigorous and transparent evaluation of the published literature to estimate the extent of vaccine effect. Unfortunately, the published body of evidence does not provide a consistent estimate of the direction and magnitude of effectiveness in feedlot cattle vaccination against Mannheimia haemolytica, Pasteurella multocida, or Histophilus somni.
authors.affiliation: Department of Clinical Sciences, College of Veterinary Medicine, Kansas State University, 1800 Denison Avenue, Manhattan, KS 66506, USA. RLarson@vet.k-state.edu
authors.forename: R L
authors.initials: RL
authors.lastname: Larson
authors.forename: D L
authors.initials: DL
authors.lastname: Step
mesh_terms: D000818:Animals; D048090:Bovine Respiratory Disease Complex / Q000453:epidemiology / Q000517:prevention & control*; D002417:Cattle; D019317:Evidence-Based Medicine; D015994:Incidence; D016978:Mannheimia haemolytica / Q000276:immunology*; D016979:Pasteurella multocida / Q000276:immunology*; D015661:Pasteurellaceae / Q000276:immunology*; D014611:Vaccination / Q000662:veterinary*