title: Post-influenza pneumonia caused by the USA300 community-associated methicillin-resistant Staphylococcus aureus in Korea.
abstract: Panton-Valentine leukocidin (PVL)-positive USA300 clone has been the most successful community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) clone spreading in North America. In contrast, PVL-negative ST72-CA-MRSA has been predominant in Korea, and there has been no report of infections by the USA300 strain except only one case report of perianal infection. Here, we describe the first case of pneumonia caused by the USA300 strain following pandemic influenza A (H1N1) in Korea. A 50-year-old man was admitted with fever and cough and chest radiograph showed pneumonic consolidation at the right lower lung zone. He received a ventilator support because of respiratory failure. PCR for pandemic influenza A (H1N1) in nasopharyngeal swab was positive, and culture of sputum and endotracheal aspirate grew MRSA. Typing of the isolate revealed that it was PVL-positive, ST 8-MRSA-SCCmec type IV. The analysis of the PFGE patterns showed that this isolate was the same pulsotype as the USA300 strain.
authors.affiliation: Division of Infectious Diseases, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Kyung Mok
authors.initials: KM
authors.lastname: Sohn
authors.forename: Doo Ryeon
authors.initials: DR
authors.lastname: Chung
authors.forename: Jin Yang
authors.initials: JY
authors.lastname: Baek
authors.forename: So Hyun
authors.initials: SH
authors.lastname: Kim
authors.forename: Eun-Jeong
authors.initials: EJ
authors.lastname: Joo
authors.forename: Young Eun
authors.initials: YE
authors.lastname: Ha
authors.forename: Kwan Soo
authors.initials: KS
authors.lastname: Ko
authors.forename: Cheol-In
authors.initials: CI
authors.lastname: Kang
authors.forename: Kyong Ran
authors.initials: KR
authors.lastname: Peck
authors.forename: Jae-Hoon
authors.initials: JH
authors.lastname: Song
mesh_terms: D017714:Community-Acquired Infections / Q000209:etiology* / Q000382:microbiology; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype; D007251:Influenza, Human / Q000150:complications*; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000145:classification / Q000302:isolation & purification; D008875:Middle Aged; D011023:Pneumonia, Staphylococcal / Q000209:etiology* / Q000382:microbiology; D056910:Republic of Korea; D013203:Staphylococcal Infections / Q000209:etiology* / Q000382:microbiology