title: Host immune defense against Aspergillus fumigatus: insight from experimental systemic (disseminated) infection.
abstract: Model of systemic Aspergillus fumigatus infection induced by intravenous application of conidia is suitable for studying important aspects of invasive aspergillosis including relationship between infection and mortality, dissemination of infection and immune mechanisms involved in host resistance to this fungus. Use of this model allows the investigation of both innate and adaptive immune response characteristics in resistant/susceptible host, and investigating the contribution of genetic background and cytokine gene deficiency improves the knowledge of the diversity of mechanisms of immune response to Aspergillus infection. Studying of various aspects of systemic aspergillosis contributes to development of antifungal drugs.
authors.affiliation: Department of Ecology, Institute for Biological Research Sinisa Stankovic, University of Belgrade, Bulevar Despota Stefana 142, 11060 Belgrade, Serbia.
authors.forename: I
authors.initials: I
authors.lastname: Mirkov
authors.forename: S
authors.initials: S
authors.lastname: Stosic-Grujicic
authors.forename: M
authors.initials: M
authors.lastname: Kataranovski
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D001228:Aspergillosis / Q000276:immunology* / Q000401:mortality; D001232:Aspergillus fumigatus / Q000276:immunology*; D006801:Humans; D008263:Macrophage Migration-Inhibitory Factors / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D013154:Spleen / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D008263:Macrophage Migration-Inhibitory Factors