title: Acute and chronic skin graft-versus-host disease--pathophysiological aspects.
abstract: Despite impressive advances in the field of allogeneic hematopoietic transplantation, graft-versus-host disease (GVHD) remains a significant obstacle to overcome. Whereas our understanding of the pathophysiology of acute GVHD has greatly improved, so has our knowledge of the complexities of the immune system. Much of the immunobiology of GVHD has been gleaned from preclinical models and far less from clinical observations or biological studies in human. In this chapter, we summarize some of the major advances in GVHD pathophysiology, and the potent translation of these from the bench to the bedside.
authors.affiliation: AP-HP, Hematology Transplantation, Saint Louis Hospital, 1 Avenue Claude Vellefaux, Paris CEDEX 10, France. gerard.socie@sls.aphp.fr
authors.forename: Gerard
authors.initials: G
authors.lastname: Socié
authors.forename: Regis
authors.initials: R
authors.lastname: Peffault de Latour
authors.forename: Jean David
authors.initials: JD
authors.lastname: Bouziz
authors.forename: Michel
authors.initials: M
authors.lastname: Rybojad
mesh_terms: D000208:Acute Disease; D002908:Chronic Disease; D006086:Graft vs Host Disease / Q000276:immunology* / Q000503:physiopathology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006801:Humans; D012871:Skin Diseases / Q000276:immunology* / Q000503:physiopathology; D016176:T-Lymphocyte Subsets / Q000276:immunology