title: An ulcerated lesion due to HSV-2 infection with a CD56+ cell predominant inflammatory infiltrate.
abstract: CD56+ rich inflammatory infiltrates have been described in several cutaneous inflammatory conditions. However, CD56+ cells rarely account for more than 10% of the cells in such infiltrates. In certain conditions, such as insect bites or infection with herpes virus, CD56+ cells can be up to 43% of the cells in the infiltrate. This contrasts with what is observed in natural killer (NK)-cell lymphomas, which show a diffuse, atypical infiltrate in which most of the cells are CD56+. In this report, we describe a lymphocytic infiltrate in an ulcerated lesion on the lip of a 53-year-old man resulting from infection with herpes simplex virus type 2. CD56+ cells represented 80 to 90% of the infiltrate, showing atypical morphologic features, and clusters of CD56 positive cells were also observed.
authors.affiliation: Department of Anatomic Pathology, PathCell Clinica Ponferrada, Spain. gpyauflowerlion@terra.es
authors.forename: Angel
authors.initials: A
authors.lastname: Fernandez-Flores
authors.forename: Nuria
authors.initials: N
authors.lastname: Rodriguez-Prado
mesh_terms: D019002:CD56 Antigen / Q000276:immunology*; D006561:Herpes Simplex / Q000276:immunology* / Q000473:pathology; D018258:Herpesvirus 2, Human; D006801:Humans; D008297:Male; D008875:Middle Aged; D019226:Oral Ulcer / Q000276:immunology* / Q000473:pathology / Q000821:virology*
chemical_list: D019002:CD56 Antigen