title: Relationship between status of plasma atrial natriuretic peptide and heart rate variability in human subjects.
abstract: A relationship may exist between plasma atrial natriuretic peptide (P-ANP) and heart rate variability (HRV), which reflects the activity of the autonomic nervous system. We performed a survey in human subjects to examine the relationship between P-ANP and HRV parameters. Three ethnic groups (Han, Uygur, and Kazakh) provided blood and urine samples and underwent 24-h ambulatory blood pressure monitoring and 24-h ECG recording (24-h Holter ECG). There was a positive correlation between P-ANP and HF, as well as a negative correlation between P-ANP and the LF/HF ratio, in all subjects from the 3 ethnic groups. There was no association of BP with any of the blood, urinary, and HRV parameters. Our results suggested the possibility of a relationship between P-ANP and HRV, which reflects autonomic activity. These findings are consistent with the previous report of a close relationship between ANP and cardiac parasympathetic and/or sympathetic activity.
authors.affiliation: Division of Cardiology, Department of Medicine, Nihon University School of Medicine, 30-1 Ooyaguchi Kamimachi, Itabashiku, Tokyo, 173-8610, Japan. kasamaki.yuuji@nihon-u.ac.jp
authors.forename: Yuji
authors.initials: Y
authors.lastname: Kasamaki
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Izumi
authors.forename: Yukio
authors.initials: Y
authors.lastname: Ozawa
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Ohta
authors.forename: Ayako
authors.initials: A
authors.lastname: Tano
authors.forename: Ichiro
authors.initials: I
authors.lastname: Watanabe
authors.forename: Atsushi
authors.initials: A
authors.lastname: Hirayama
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Nakayama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawamura
authors.forename: Dilxat
authors.initials: D
authors.lastname: Himit
authors.forename: Maisumu
authors.initials: M
authors.lastname: Mahemuti
authors.forename: Akira
authors.initials: A
authors.lastname: Sezai
mesh_terms: D000368:Aged; D044466:Asian People; D009320:Atrial Natriuretic Factor / Q000097:blood*; D001341:Autonomic Nervous System / Q000502:physiology*; D015415:Biomarkers / Q000097:blood; D018660:Blood Pressure Monitoring, Ambulatory; D002681:China / Q000453:epidemiology; D002940:Circadian Rhythm; D015716:Electrocardiography, Ambulatory; D005260:Female; D006321:Heart / Q000294:innervation*; D006339:Heart Rate; D006801:Humans; D016014:Linear Models; D008297:Male; D015999:Multivariate Analysis; D013997:Time Factors
chemical_list: D015415:Biomarkers; D009320:Atrial Natriuretic Factor