title: Margin status, local recurrence, and survival: correlation or causation?
abstract: The relationship between surgical margin status and outcomes in sarcoma has been an area of controversy for years. Some question whether a positive margin represents inadequate surgery or perhaps is a marker of aggressive cancer biology. This article reviews the literature regarding the natural history of positive margins and its possible influence on sarcoma recurrence and survival.
authors.affiliation: Surgical Oncology, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA.
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Nurkin
authors.forename: John M
authors.initials: JM
authors.lastname: Kane
mesh_terms: D018572:Disease-Free Survival; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000401:mortality; D059351:Organ Sparing Treatments / Q000379:methods / Q000401:mortality; D012307:Risk Factors; D012509:Sarcoma / Q000401:mortality / Q000601:surgery*; D012983:Soft Tissue Neoplasms / Q000401:mortality / Q000601:surgery*; D016896:Treatment Outcome