title: Allophagy: a macroautophagic process degrading spermatozoid-inherited organelles.
abstract: In most animals, during oocyte fertilization the spermatozoon provides DNA and centrioles together with some cytoplasm and organelles, but paternal mitochondria are generally eliminated in the embryo. Using the model animal C. elegans we have shown that paternal organelle degradation is dependent on the formation of autophagosomes a few minutes after fertilization. This macroautophagic process is preceded by an active ubiquitination of some spermatozoon-inherited organelles. Analysis of fertilized mouse embryos suggests that this autophagy event is evolutionarily conserved.
authors.affiliation: UPMC Université Paris 06, UMR7622-Biologie du Développement, Paris, France.
authors.forename: Sara
authors.initials: S
authors.lastname: Al Rawi
authors.forename: Sophie
authors.initials: S
authors.lastname: Louvet-Vallée
authors.forename: Abderazak
authors.initials: A
authors.lastname: Djeddi
authors.forename: Martin
authors.initials: M
authors.lastname: Sachse
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Culetto
authors.forename: Connie
authors.initials: C
authors.lastname: Hajjar
authors.forename: Lynn
authors.initials: L
authors.lastname: Boyd
authors.forename: Renaud
authors.initials: R
authors.lastname: Legouis
authors.forename: Vincent
authors.initials: V
authors.lastname: Galy
mesh_terms: D000818:Animals; D001343:Autophagy; D017173:Caenorhabditis elegans / Q000166:cytology* / Q000378:metabolism* / Q000648:ultrastructure; D049452:Green Fluorescent Proteins / Q000378:metabolism; D008297:Male; D051379:Mice; D015388:Organelles / Q000378:metabolism*; D013094:Spermatozoa / Q000166:cytology* / Q000378:metabolism* / Q000648:ultrastructure; D025801:Ubiquitin / Q000378:metabolism
chemical_list: D025801:Ubiquitin; D049452:Green Fluorescent Proteins