title: Hypothermia attenuates the severity of oxidative stress development in asphyxiated newborns.
abstract: OBJECTIVE
  This retrospective case-control study aimed to examine the development of oxidative stress in asphyxiated infants delivered at more than 37 weeks of gestation.
  
  
  METHODS
  Thirty-seven neonates were stratified into 3 groups: the first group experienced hypothermia (n = 6); the second received hypothermia cooling cup treatment for 3 days, normothermia (n = 16); and the third was the control group (n = 15). Serum total hydroperoxide (TH), biological antioxidant potential, and oxidative stress index (OSI) (calculated as TH/biological antioxidant potential) were measured within 3 hours after birth.
  
  
  RESULTS
  Serum TH and OSI levels gradually increased after birth in hypothermia and normothermia cases. At all time points, serum TH and OSI levels were higher in hypothermia and normothermia cases than in control cases. Serum TH and OSI levels were higher in normothermia cases than in hypothermia cases at days 3, 5, and 7.
  
  
  CONCLUSIONS
  This study demonstrated that hypothermia attenuated the development of systemic oxidative stress in asphyxiated newborns.
authors.affiliation: Department of Pediatrics and Neonatology, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
authors.forename: Hiroki
authors.initials: H
authors.lastname: Kakita
authors.forename: Mohamed Hamed
authors.initials: MH
authors.lastname: Hussein
authors.forename: Shin
authors.initials: S
authors.lastname: Kato
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Yamada
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Nagaya
authors.forename: Hayato
authors.initials: H
authors.lastname: Asai
authors.forename: Tatenobu
authors.initials: T
authors.lastname: Goto
authors.forename: Koichi
authors.initials: K
authors.lastname: Ito
authors.forename: Tokio
authors.initials: T
authors.lastname: Sugiura
authors.forename: Ghada Abdel-Hamid
authors.initials: GA
authors.lastname: Daoud
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Ito
authors.forename: Ineko
authors.initials: I
authors.lastname: Kato
authors.forename: Hajime
authors.initials: H
authors.lastname: Togari
mesh_terms: D001034:Apgar Score; D001238:Asphyxia Neonatorum / Q000628:therapy*; D001724:Birth Weight; D005260:Female; D005865:Gestational Age; D006801:Humans; D006861:Hydrogen Peroxide / Q000097:blood; D007036:Hypothermia, Induced / Q000379:methods*; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal; D008297:Male; D018384:Oxidative Stress; D012189:Retrospective Studies
chemical_list: D006861:Hydrogen Peroxide