title: Dopamine-deficiency-enhanced hyperthermia and rhabdomyolysis during a heat wave in a metachromatic leucodystrophy heterozygote with metabolic myopathy.
abstract: Whether a dopamine-deficiency syndrome in a Parkinson-syndrome (PS) may occur more easily during a heat wave than during more temperate climate conditions is unknown. We report a case that may suggest this. A 56 yo male with heterozygosity for metachromatic leucodystrophy and a history of metabolic myopathy, PS and diabetes experienced worsening of the PS during a heat wave. His condition further deteriorated upon reduction of ropinirol, resulting in hyperthermia, respiratory insufficiency, rhabdomyolysis, and severe thrombocytopenia. One month later he was alert but tetraplegic and required ventilatory support. Hyper-CK-emia returned to similar levels as before rhabdomyolysis. Reduction of dopamine agonists during a heat wave may induce a dopamine deficiency syndrome with hyperthermia, rhabdomyolysis and thrombocytopenia.
authors.affiliation: fifigs1@yahoo.de
authors.forename: Josef
authors.initials: J
authors.lastname: Finsterer
authors.forename: Alice
authors.initials: A
authors.lastname: Reining-Festa
authors.forename: Claudia
authors.initials: C
authors.lastname: Stollbergr
authors.forename: Till
authors.initials: T
authors.lastname: Voigtlander
mesh_terms: D000978:Antiparkinson Agents / Q000008:administration & dosage; D004298:Dopamine / Q000172:deficiency*; D005334:Fever / Q000209:etiology*; D006801:Humans; D007211:Indoles / Q000008:administration & dosage; D007966:Leukodystrophy, Metachromatic / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009135:Muscular Diseases / Q000150:complications* / Q000378:metabolism; D012206:Rhabdomyolysis / Q000209:etiology* / Q000378:metabolism
chemical_list: D000978:Antiparkinson Agents; D007211:Indoles; C046649:ropinirole; D004298:Dopamine