title: Acylated flavonol glycosides from Epimedium elatum, a plant endemic to the Western Himalayas.
abstract: Herba Epimedii is a well-known Botanical preparation used over long time in traditional Chinese medicine. The extracts and chemical constituents from Epimedium species are aphrodisiac as well as to treat many ailments. Chemical investigation of lonely species growing in Kashmir Himalaya Epimedium elatum was undertaken to evaluate its chemical profile. Two unusual substituted acylated flavonol glycosides named Elatoside A (1) and Elatoside B (2) have been isolated from the ethanolic extract of E. elatum along with 23 previously known ones (3-25). All isolates were evaluated for antimicrobial and PPAR-γ ligand binding activity, and some of them appeared to be modestly active.
authors.affiliation: National Center for Natural Products Research, Research Institute of Pharmaceutical Sciences, School of Pharmacy, The University of Mississippi, MS 38677, USA. mtantry@olemiss.edu
authors.forename: Mudasir A
authors.initials: MA
authors.lastname: Tantry
authors.forename: Javid A
authors.initials: JA
authors.lastname: Dar
authors.forename: Ahmed
authors.initials: A
authors.lastname: Idris
authors.forename: Seema
authors.initials: S
authors.lastname: Akbar
authors.forename: Abdul S
authors.initials: AS
authors.lastname: Shawl
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000302:isolation & purification / Q000494:pharmacology; D001208:Asia; D002460:Cell Line; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000494:pharmacology; D034181:Epimedium / Q000737:chemistry*; D000882:Haplorhini; D007668:Kidney / Q000187:drug effects; D008516:Medicine, Chinese Traditional; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D047495:PPAR gamma / Q000378:metabolism; D012503:Saponins / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D004365:Drugs, Chinese Herbal; D047495:PPAR gamma; D012503:Saponins; C102411:elatoside A; C102412:elatoside B; D009828:Oleanolic Acid