title: Antimicrobial constituents from the tubers of Bletilla ochracea.
abstract: A new 2-(2-methylpropyl)butanedioic acid derivative, bletillin A ( 1), and a new bibenzyl, bletillin B ( 2), together with seventeen known compounds ( 3- 19), were isolated from the tubers of Bletilla ochracea Schltr. Their structures were established by detailed spectroscopic analyses. Phenanthrenes ( 12- 14) exhibited antibacterial activities against gram-positive bacteria Staphylococcus aureus, S. epidermidis, and Bacillus subtilis, with MIC values of 12.5-25 µg/mL.
authors.affiliation: College of Pharmacy, South-Central University for Nationalities, Wuhan, P. R. China.
authors.forename: Xinzhou
authors.initials: X
authors.lastname: Yang
authors.forename: Chunping
authors.initials: C
authors.lastname: Tang
authors.forename: Ping
authors.initials: P
authors.lastname: Zhao
authors.forename: Guangwen
authors.initials: G
authors.lastname: Shu
authors.forename: Zhinan
authors.initials: Z
authors.lastname: Mei
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D001632:Bibenzyls / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D001681:Biological Assay; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D029595:Orchidaceae / Q000737:chemistry*; D010616:Phenanthrenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D035281:Plant Tubers / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects; D013212:Staphylococcus epidermidis / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D001632:Bibenzyls; D004365:Drugs, Chinese Herbal; D010616:Phenanthrenes; C576418:bletillin A; C576419:bletillin B