title: Large cell neuroendocrine carcinoma of the thymus: a two-case report.
abstract: A large cell neuroendocrine carcinoma (LCNEC) of the thymus is a very rare malignant tumor that has a very poor prognosis. The detailed clinical features of LCNEC are still unknown, including the long term prognoses and the definitive modalities of the treatment for LCNEC of the thymus. We are reporting 2 cases of an enlarged LCNEC of the thymus, both of which were diagnosed and treated by surgical resection followed by postoperative adjuvant chemoradiation therapy. Although recurrences and metastases of the LCNEC were noticed 1 and 4 years postoperatively for each case, aggressive surgical resection and adjuvant chemoradiation therapy may be helpful for a patient's long term survival.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, Inha University Hospital, Inha University School of Medicine, Korea.
authors.forename: Yong Han
authors.initials: YH
authors.lastname: Yoon
authors.forename: Jae Ho
authors.initials: JH
authors.lastname: Kim
authors.forename: Kwang Ho
authors.initials: KH
authors.lastname: Kim
authors.forename: Wan Ki
authors.initials: WK
authors.lastname: Baek
authors.forename: Hyun Kyu
authors.initials: HK
authors.lastname: Lee
authors.forename: Moon Hee
authors.initials: MH
authors.lastname: Lee
authors.forename: Kyung Hee
authors.initials: KH
authors.lastname: Lee
authors.forename: Lucia
authors.initials: L
authors.lastname: Kim