title: Serum amyloid A levels associated with gastrointestinal manifestations in Henoch-Schönlein purpura.
abstract: Henoch-Schönlein purpura (HSP) is considered as an immune-mediated inflammatory disease. Serum amyloid A (SAA) is an acute-phase protein with proinflammatory effects. We investigated the levels of SAA in HSP patients and examined whether SAA levels are associated with organ involvement and disease severity. Seventy patients with HSP, including 35 with nephritis (HSPN) and 35 without HSPN, and 20 controls were recruited in our study. SAA levels were measured and other clinical laboratory parameters, including C-reactive protein, erythrocyte sedimentation rate, complement 3 (C3), C4, and immunoglobulin (Ig) A, were recorded. SAA levels were not found to be independently associated with renal, joint involvement, and disease severity. However, higher SAA levels were observed in HSP patients with gastrointestinal (GI) manifestations (p=0.006, p (c)=0.048). Moreover, the levels of SAA were significantly associated with duration of disease (p<0.005, p(c)<0.04). Our findings suggested that SAA was significantly associated with disease duration and GI manifestations in HSP patients.
authors.affiliation: Wuhan Children's Hospital, No. 100 Hongkong Rd, Wuhan, Jiangan District, People's Republic of China. hxljm07@hotmail.com
authors.forename: Xuelian
authors.initials: X
authors.lastname: He
authors.forename: Yulan
authors.initials: Y
authors.lastname: Zhao
authors.forename: Yin
authors.initials: Y
authors.lastname: Li
authors.forename: Shixiu
authors.initials: S
authors.lastname: Kang
authors.forename: Yan
authors.initials: Y
authors.lastname: Ding
authors.forename: Jiangwei
authors.initials: J
authors.lastname: Luan
authors.forename: Peiwei
authors.initials: P
authors.lastname: Zhao
authors.forename: Ningsheng
authors.initials: N
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Yin
mesh_terms: D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000032:analysis; D003176:Complement C3 / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D005260:Female; D005767:Gastrointestinal Diseases / Q000097:blood*; D006801:Humans; D011695:IgA Vasculitis / Q000097:blood*; D007070:Immunoglobulin A / Q000097:blood; D008297:Male; D009393:Nephritis / Q000097:blood* / Q000150:complications; D000685:Serum Amyloid A Protein / Q000032:analysis*
chemical_list: D003176:Complement C3; D003181:Complement C4; D007070:Immunoglobulin A; D000685:Serum Amyloid A Protein; D002097:C-Reactive Protein