title: Successful treatment of Cryptococcus gattii neurocryptococcosis in a 5-year-old immunocompetent child from the French Guiana Amazon region.
abstract: Compared to the incidence in adults, cryptococcosis is rare among children. We report a case of neurocryptococcosis due to Cryptococcus gattii in a five-year-old girl without identified risk factors living in French Guiana. Neurological surgery in combination with long-term antifungal treatment with amphotericin B and 5-flucytosine successfully resolved the cryptococcal infection. Subsequent molecular characterization of the Cryptococcus isolate revealed that the infection was caused by a C. gattii genotype AFLP6B/VGIIb strain.
authors.affiliation: Laboratoire Hospitalier et Universitaire de Parasitologie-Mycologie, CH Andrée Rosemon et et EA 3593, Faculté de Médecine, Université des Antilles et de la Guyane, Cayenne, Guiana.
authors.forename: Anne
authors.initials: A
authors.lastname: Debourgogne
authors.forename: Ferry
authors.initials: F
authors.lastname: Hagen
authors.forename: Narcisse
authors.initials: N
authors.lastname: Elenga
authors.forename: Laurence
authors.initials: L
authors.lastname: Long
authors.forename: Denis
authors.initials: D
authors.lastname: Blanchet
authors.forename: Vincent
authors.initials: V
authors.lastname: Veron
authors.forename: Olivier
authors.initials: O
authors.lastname: Lortholary
authors.forename: Bernard
authors.initials: B
authors.lastname: Carme
authors.forename: Christine
authors.initials: C
authors.lastname: Aznar
mesh_terms: D020314:Central Nervous System Fungal Infections / Q000628:therapy*; D002675:Child, Preschool; D003453:Cryptococcosis / Q000628:therapy*; D056285:Cryptococcus gattii; D005260:Female; D005616:French Guiana; D006801:Humans; D012074:Remission Induction