title: Suzuki coupling of potassium cyclopropyl- and alkoxymethyltrifluoroborates with benzyl chlorides.
abstract: Efficient Csp(3)-Csp(3) Suzuki couplings have been developed with both potassium cyclopropyl- and alkoxymethyltrifluoroborates. Moderate to good yields have been achieved in the cross-coupling of potassium cyclopropyltrifluoroborate with benzyl chlorides possessing electron-donating or electron-withdrawing substituents. Benzyl chloride was also successfully cross-coupled to potassium alkoxymethyltrifluoroborates derived from primary, secondary, and tertiary alcohols.
authors.affiliation: Neuroscience Medicinal Chemistry, Research and Development, Janssen Pharmaceutica, Turnhoutseweg 30, 2340 Beerse, Belgium.
authors.forename: Virginie
authors.initials: V
authors.lastname: Colombel
authors.forename: Frederik
authors.initials: F
authors.lastname: Rombouts
authors.forename: Daniel
authors.initials: D
authors.lastname: Oehlrich
authors.forename: Gary A
authors.initials: GA
authors.lastname: Molander
mesh_terms: D001593:Benzyl Compounds / Q000737:chemistry*; D001881:Borates / Q000737:chemistry*; D003432:Cross-Linking Reagents / Q000737:chemistry*; D003521:Cyclopropanes / Q000737:chemistry*; D015394:Molecular Structure; D011188:Potassium / Q000737:chemistry*; D020002:tert-Butyl Alcohol / Q000031:analogs & derivatives* / Q000737:chemistry*
chemical_list: D001593:Benzyl Compounds; D001881:Borates; D003432:Cross-Linking Reagents; D003521:Cyclopropanes; C021292:benzyl chloride; D020002:tert-Butyl Alcohol; D011188:Potassium