title: Nesfatin-1 and other hormone alterations in polycystic ovary syndrome.
abstract: Polycystic ovary syndrome (PCOS) is commonly characterised by obesity, insulin resistance (IR), hyperandrogenemia and hirsutism. Nesfatin-1 a recently discovered hormone, acts upon energy balance, glucose metabolism, obesity and probably gonadal functions. This study was to evaluate the circulating levels of nesfatin-1 in patients with PCOS (n = 30) and in age and body mass index (BMI)-matched controls (n = 30). PCOS patients had significantly lower levels of nesfatin-1 (0.88 ± 0.36 ng/mL) than healthy controls (2.22 ± 1.14 ng/mL). PCOS patients also had higher gonadotropin and androgen plasma concentrations, Ferriman-Gallwey scores, blood glucose levels and a homeostasis model of assessment-IR index (HOMA-IR) index than in healthy women. Correlation tests in PCOS subjects detected a negative correlation between nesfatin-1 levels and BMI, fasting blood glucose, insulin levels and a HOMA-IR index. Lower nesfatin-1 concentration may plays a very important role in the development of PCOS.
authors.affiliation: Department of Obstetrics and Gynecology, Firat University Hospital, Elazig, Turkey.
authors.forename: Rulin
authors.initials: R
authors.lastname: Deniz
authors.forename: Bilgin
authors.initials: B
authors.lastname: Gurates
authors.forename: Suleyman
authors.initials: S
authors.lastname: Aydin
authors.forename: Husnu
authors.initials: H
authors.lastname: Celik
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Sahin
authors.forename: Yakup
authors.initials: Y
authors.lastname: Baykus
authors.forename: Zekiye
authors.initials: Z
authors.lastname: Catak
authors.forename: Aziz
authors.initials: A
authors.lastname: Aksoy
authors.forename: Cihan
authors.initials: C
authors.lastname: Citil
authors.forename: Sami
authors.initials: S
authors.lastname: Gungor
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D015992:Body Mass Index; D002135:Calcium-Binding Proteins / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D005260:Female; D006728:Hormones / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D000080866:Nucleobindins; D011085:Polycystic Ovary Syndrome / Q000378:metabolism*; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; D006728:Hormones; D007328:Insulin; D008055:Lipids; C000630650:NUCB2 protein, human; D009419:Nerve Tissue Proteins; D000080866:Nucleobindins