title: Efficacy of the Combination of Tetracycline, Amoxicillin, and Lansoprazole in the Eradication of Helicobacter pylori in Treatment-Naïve Patients and in Patients Who Are Not Responsive to Clarithromycin-Based Regimens: A Pilot Study.
abstract: OBJECTIVE
  The aim of this study was to evaluate the eradication rate of a triple therapy regimen that included a proton pump inhibitor, amoxicillin, and tetracycline instead of clarithromycin in treatment-Naïve patients and in patients who did not respond to standard triple therapy.
  
  
  METHODS
  This study included 110 patients infected with Helicobacter pylori. Patients in groups A and B were treatment-Naïve, and those in group C were not responsive to previous standard triple therapy. Patients in group A (n=40) received lansoprazole 30 mg b.i.d., amoxicillin 1,000 mg b.i.d., and clarithromycin 500 mg b.i.d. for 14 days. Patients in groups B (n=40) and C (n=30) received lansoprazole 30 mg b.i.d., amoxicillin 1,000 mg b.i.d., and tetracycline 500 mg q.i.d. for 14 days.
  
  
  RESULTS
  In group A, eradication was achieved in 18 (45%) of the 40 patients included in the intention-to-treat (ITT) analysis and in 18 (47.4%) of the 38 patients included in the per-protocol (PP) analysis. In group B, eradication was achieved in 15 (37.5%) of the 40 patients included in the ITT analysis and in 15 (39.3%) of the 38 patients included in the PP analysis. In group C, eradication was achieved in 14 (46.6%) of the 30 patients included in the ITT analysis and in 14 (43.8%) of the 29 patients included in the PP analysis. There was no statistically significant difference among the 3 groups with regard to eradication rates (p>0.05).
  
  
  CONCLUSIONS
  Despite the low rate of resistance to tetracycline, the combination of lansoprazole, amoxicillin, and tetracycline instead of clarithromycin is not a good option for the eradication of H. pylori.
authors.affiliation: Department of Gastroenterology, Haydarpaşa Numune Education and Research Hospital, Istanbul, Turkey.
authors.forename: Mesut
authors.initials: M
authors.lastname: Sezikli
authors.forename: Züleyha Akkan
authors.initials: ZA
authors.lastname: Cetinkaya
authors.forename: Fatih
authors.initials: F
authors.lastname: Güzelbulut
authors.forename: Atakan
authors.initials: A
authors.lastname: Yeşil
authors.forename: Mustafa Erhan
authors.initials: ME
authors.lastname: Alt Nöz
authors.forename: Nuriye
authors.initials: N
authors.lastname: Ulu
authors.forename: Ayşe Oya
authors.initials: AO
authors.lastname: Ovünç Kurdaş