title: The role of bacterial lipopolysaccharides as immune modulator in vaccine and drug development.
abstract: Bacterial lipopolysaccharide (LPS, endotoxin) is the major constituent of the outer membrane of Gram-negative bacteria. LPS can cause a variety of immune- and cellular disorders that lead to lethal effects and clinical manifestations of infectious diseases. Several molecular and cellular in vitro techniques, besides synthesis of analogous molecules of the LPS active region, have provided insight in the molecular mechanisms of LPS bioactivity in cellular systems. These advances have facilitated the application of diverse LPS-based molecules in relevant areas such as vaccine technology, allergen immunotherapy, treatment of immune-related diseases/disorders, LPS-related inflammatory processes and sepsis. The purpose of this review is to examine the progress in the generation of new LPS-based molecules and their therapeutic potential.
authors.affiliation: Department of Microbiology, Utrecht University, Utrecht, The Netherlands. jesusarenasbust@yahoo.es
authors.forename: Jesús
authors.initials: J
authors.lastname: Arenas
mesh_terms: D000818:Animals; D015195:Drug Design; D006801:Humans; D007154:Immune System Diseases / Q000188:drug therapy* / Q000276:immunology; D007155:Immunologic Factors / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007167:Immunotherapy / Q000379:methods; D008070:Lipopolysaccharides / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D018805:Sepsis / Q000188:drug therapy / Q000276:immunology; D014612:Vaccines / Q000276:immunology* / Q000627:therapeutic use
chemical_list: D007155:Immunologic Factors; D007166:Immunosuppressive Agents; D008070:Lipopolysaccharides; D014612:Vaccines