title: Diabetes and mucormycosis: a complex interplay.
abstract: Mucormycosis is a life-threatening invasive fungal infection that arises particularly in diabetic patients with or without other underlying conditions such as haematological malignancies or the need for solid-organ transplantation. Rhino-orbito-cerebral involvement is the primary site of mucormycosis, but the paucity of signs may be a cause of delayed diagnosis. Thus, any case of documented non-bacteriological sinusitis in diabetic patients, even without ketoacidosis, should prompt suspicion of a mucormycosis diagnosis. To optimalize information for clinicians in charge of diabetic patients, this extensive review of the literature was carried out to provide an overview of mucormycosis specificities, epidemiology and pathophysiology in the setting of diabetes.
authors.affiliation: Service des Maladies Infectieuses et Tropicales, Centre d'Infectiologie Necker-Pasteur, Université Paris Descartes, Hôpital Necker-Enfants-Malades, Institut Imagine, AP-HP, 149, rue des Sèvres, 75743 Paris cedex 15, France.
authors.forename: B
authors.initials: B
authors.lastname: Rammaert
authors.forename: F
authors.initials: F
authors.lastname: Lanternier
authors.forename: S
authors.initials: S
authors.lastname: Poirée
authors.forename: R
authors.initials: R
authors.lastname: Kania
authors.forename: O
authors.initials: O
authors.lastname: Lortholary
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use; D048909:Diabetes Complications / Q000175:diagnosis / Q000453:epidemiology / Q000382:microbiology* / Q000503:physiopathology / Q000628:therapy; D003937:Diagnosis, Differential; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D006801:Humans; D009091:Mucormycosis / Q000175:diagnosis* / Q000453:epidemiology / Q000382:microbiology / Q000503:physiopathology / Q000628:therapy*; D009894:Opportunistic Infections / Q000150:complications / Q000382:microbiology*; D010586:Phagocytes / Q000276:immunology; D012307:Risk Factors; D012852:Sinusitis / Q000382:microbiology*; D014057:Tomography, X-Ray Computed
chemical_list: D000935:Antifungal Agents