title: Are myocardial infarction--associated single-nucleotide polymorphisms associated with ischemic stroke?
abstract: OBJECTIVE
  Ischemic stroke (IS) shares many common risk factors with coronary artery disease (CAD). We hypothesized that genetic variants associated with myocardial infarction (MI) or CAD may be similarly involved in the etiology of IS. To test this hypothesis, we evaluated whether single-nucleotide polymorphisms (SNPs) at 11 different loci recently associated with MI or CAD through genome-wide association studies were associated with IS.
  
  
  METHODS
  Meta-analyses of the associations between the 11 MI-associated SNPs and IS were performed using 6865 cases and 11 395 control subjects recruited from 9 studies. SNPs were either genotyped directly or imputed; in a few cases a surrogate SNP in high linkage disequilibrium was chosen. Logistic regression was performed within each study to obtain study-specific βs and standard errors. Meta-analysis was conducted using an inverse variance weighted approach assuming a random effect model.
  
  
  RESULTS
  Despite having power to detect odds ratio of 1.09-1.14 for overall IS and 1.20-1.32 for major stroke subtypes, none of the SNPs were significantly associated with overall IS and/or stroke subtypes after adjusting for multiple comparisons.
  
  
  CONCLUSIONS
  Our results suggest that the major common loci associated with MI risk do not have effects of similar magnitude on overall IS but do not preclude moderate associations restricted to specific IS subtypes. Disparate mechanisms may be critical in the development of acute ischemic coronary and cerebrovascular events.
authors.affiliation: Department of Medicine, University of Maryland School of Medicine, 660 W Redwood St, Howard Hall, Room 492, Baltimore, MD 21201, USA.
authors.forename: Yu-Ching
authors.initials: YC
authors.lastname: Cheng
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Anderson
authors.forename: Silvia
authors.initials: S
authors.lastname: Bione
authors.forename: Keith
authors.initials: K
authors.lastname: Keene
authors.forename: Jane M
authors.initials: JM
authors.lastname: Maguire
authors.forename: Michael
authors.initials: M
authors.lastname: Nalls
authors.forename: Asif
authors.initials: A
authors.lastname: Rasheed
authors.forename: Marion
authors.initials: M
authors.lastname: Zeginigg
authors.forename: John
authors.initials: J
authors.lastname: Attia
authors.forename: Ross
authors.initials: R
authors.lastname: Baker
authors.forename: Simona
authors.initials: S
authors.lastname: Barlera
authors.forename: Alessandro
authors.initials: A
authors.lastname: Biffi
authors.forename: Ebony
authors.initials: E
authors.lastname: Bookman
authors.forename: Thomas G
authors.initials: TG
authors.lastname: Brott
authors.forename: Robert D
authors.initials: RD
authors.lastname: Brown
authors.forename: Fang
authors.initials: F
authors.lastname: Chen
authors.forename: Wei-Min
authors.initials: WM
authors.lastname: Chen
authors.forename: Emilio
authors.initials: E
authors.lastname: Ciusani
authors.forename: John W
authors.initials: JW
authors.lastname: Cole
authors.forename: Lynelle
authors.initials: L
authors.lastname: Cortellini
authors.forename: John
authors.initials: J
authors.lastname: Danesh
authors.forename: Kimberly
authors.initials: K
authors.lastname: Doheny
authors.forename: Luigi
authors.initials: L
authors.lastname: Ferrucci
authors.forename: Maria
authors.initials: M
authors.lastname: Grazia Franzosi
authors.forename: Philippe
authors.initials: P
authors.lastname: Frossard
authors.forename: Karen L
authors.initials: KL
authors.lastname: Furie
authors.forename: Jonathan
authors.initials: J
authors.lastname: Golledge
authors.forename: Graeme J
authors.initials: GJ
authors.lastname: Hankey
authors.forename: Dena
authors.initials: D
authors.lastname: Hernandez
authors.forename: Elizabeth G
authors.initials: EG
authors.lastname: Holliday
authors.forename: Fang-Chi
authors.initials: FC
authors.lastname: Hsu
authors.forename: Jim
authors.initials: J
authors.lastname: Jannes
authors.forename: Ayeesha
authors.initials: A
authors.lastname: Kamal
authors.forename: Muhammad Saleem
authors.initials: MS
authors.lastname: Khan
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Kittner
authors.forename: Simon A
authors.initials: SA
authors.lastname: Koblar
authors.forename: Martin
authors.initials: M
authors.lastname: Lewis
authors.forename: Lisa
authors.initials: L
authors.lastname: Lincz
authors.forename: Antonella
authors.initials: A
authors.lastname: Lisa
authors.forename: Mar
authors.initials: M
authors.lastname: Matarin
authors.forename: Pablo
authors.initials: P
authors.lastname: Moscato
authors.forename: Josyf C
authors.initials: JC
authors.lastname: Mychaleckyj
authors.forename: Eugenio A
authors.initials: EA
authors.lastname: Parati
authors.forename: Silvia
authors.initials: S
authors.lastname: Parolo
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Pugh
authors.forename: Natalia S
authors.initials: NS
authors.lastname: Rost
authors.forename: Michael
authors.initials: M
authors.lastname: Schallert
authors.forename: Helena
authors.initials: H
authors.lastname: Schmidt
authors.forename: Rodney J
authors.initials: RJ
authors.lastname: Scott
authors.forename: Jonathan W
authors.initials: JW
authors.lastname: Sturm
authors.forename: Sunaina
authors.initials: S
authors.lastname: Yadav
authors.forename: Moazzam
authors.initials: M
authors.lastname: Zaidi
authors.forename: Giorgio B
authors.initials: GB
authors.lastname: Boncoraglio
authors.forename: Christopher Royce
authors.initials: CR
authors.lastname: Levi
authors.forename: James F
authors.initials: JF
authors.lastname: Meschia
authors.forename: Jonathan
authors.initials: J
authors.lastname: Rosand
authors.forename: Michele
authors.initials: M
authors.lastname: Sale
authors.forename: Danish
authors.initials: D
authors.lastname: Saleheen
authors.forename: Reinhold
authors.initials: R
authors.lastname: Schmidt
authors.forename: Pankaj
authors.initials: P
authors.lastname: Sharma
authors.forename: Bradford
authors.initials: B
authors.lastname: Worrall
authors.forename: Braxton D
authors.initials: BD
authors.lastname: Mitchell
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002545:Brain Ischemia / Q000235:genetics*; D005260:Female; D055106:Genome-Wide Association Study; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D020521:Stroke / Q000235:genetics*