title: Preterm EEG: a multimodal neurophysiological protocol.
abstract: Since its introduction in early 1950s, electroencephalography (EEG) has been widely used in the neonatal intensive care units (NICU) for assessment and monitoring of brain function in preterm and term babies. Most common indications are the diagnosis of epileptic seizures, assessment of brain maturity, and recovery from hypoxic-ischemic events. EEG recording techniques and the understanding of neonatal EEG signals have dramatically improved, but these advances have been slow to penetrate through the clinical traditions. The aim of this presentation is to bring theory and practice of advanced EEG recording available for neonatal units.     In the theoretical part, we will present animations to illustrate how a preterm brain gives rise to spontaneous and evoked EEG activities, both of which are unique to this developmental phase, as well as crucial for a proper brain maturation. Recent animal work has shown that the structural brain development is clearly reflected in early EEG activity. Most important structures in this regard are the growing long range connections and the transient cortical structure, subplate. Sensory stimuli in a preterm baby will generate responses that are seen at a single trial level, and they have underpinnings in the subplate-cortex interaction. This brings neonatal EEG readily into a multimodal study, where EEG is not only recording cortical function, but it also tests subplate function via different sensory modalities. Finally, introduction of clinically suitable dense array EEG caps, as well as amplifiers capable of recording low frequencies, have disclosed multitude of brain activities that have as yet been overlooked.    In the practical part of this video, we show how a multimodal, dense array EEG study is performed in neonatal intensive care unit from a preterm baby in the incubator. The video demonstrates preparation of the baby and incubator, application of the EEG cap, and performance of the sensory stimulations.
authors.affiliation: Department of Children&#39;s Clinical Neurophysiology, Helsinki University Hospital, University of Helsinki.
authors.forename: Susanna
authors.initials: S
authors.lastname: Stjerna
authors.forename: Juha
authors.initials: J
authors.lastname: Voipio
authors.forename: Marjo
authors.initials: M
authors.lastname: Metsäranta
authors.forename: Kai
authors.initials: K
authors.lastname: Kaila
authors.forename: Sampsa
authors.initials: S
authors.lastname: Vanhatalo
mesh_terms: D004569:Electroencephalography / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D009359:Neonatology / Q000295:instrumentation / Q000379:methods*