title: D-cycloserine: an evolving role in learning and neuroplasticity in schizophrenia.
abstract: As a partial agonist at the glycine site of the NMDA receptor, D-cycloserine (DCS) has been viewed as lacking potency to fully test the NMDA receptor hypofunction theory of schizophrenia. However, findings of full agonist activity at a subset of NMDA receptors that may have particular relevance to schizophrenia, plus a growing body of evidence demonstrating enhancement of learning and neuroplasticity in animal models, suggest novel therapeutic strategies with DCS in schizophrenia. Preliminary studies with once-weekly administration have supported this potential new role for DCS in schizophrenia by demonstrating benefit for negative symptoms, memory consolidation, and facilitation of cognitive behavioral therapy for delusions.
authors.affiliation: Nathan Kline Psychiatric Research Institute and New York University Langone Medical Center, New York, NY, USA. dgoff@nki.rfmh.org
authors.forename: Donald C
authors.initials: DC
authors.lastname: Goff
mesh_terms: D000339:Affect / Q000187:drug effects / Q000502:physiology; D000818:Animals; D001143:Arousal / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D015928:Cognitive Behavioral Therapy; D003131:Combined Modality Therapy; D003523:Cycloserine / Q000494:pharmacology* / Q000627:therapeutic use*; D004185:Disability Evaluation; D004195:Disease Models, Animal; D004334:Drug Administration Schedule; D006801:Humans; D007858:Learning / Q000187:drug effects* / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D008568:Memory / Q000187:drug effects* / Q000502:physiology*; D008570:Memory, Short-Term / Q000187:drug effects / Q000502:physiology; D009042:Motivation / Q000187:drug effects / Q000502:physiology; D009473:Neuronal Plasticity / Q000187:drug effects* / Q000502:physiology*; D011788:Quality of Life / Q000523:psychology; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects* / Q000502:physiology*; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology*; D012565:Schizophrenic Psychology
chemical_list: D016194:Receptors, N-Methyl-D-Aspartate; D003523:Cycloserine