title: Asymmetric synthesis of γ-nitroesters by an organocatalytic one-pot strategy.
abstract: An enantioselective synthesis of γ-nitroesters by a one-pot asymmetric Michael addition/oxidative esterification of α,β-unsaturated aldehydes is presented. The procedure is based on merging the enantioselective organocatalytic nitroalkane addition with an N-bromosuccinimide-based oxidation. The γ-nitroesters are obtained in good yields and enantioselectivities, and the method provides an attractive entry to optically active γ-aminoesters, 2-piperidones, and 2-pyrrolidones.
authors.affiliation: Center for Catalysis, Department of Chemistry, Aarhus University, 8000 Aarhus C, Denmark.
authors.forename: Kim L
authors.initials: KL
authors.lastname: Jensen
authors.forename: Pernille H
authors.initials: PH
authors.lastname: Poulsen
authors.forename: Bjarke S
authors.initials: BS
authors.lastname: Donslund
authors.forename: Fabio
authors.initials: F
authors.lastname: Morana
authors.forename: Karl Anker
authors.initials: KA
authors.lastname: Jørgensen