title: [Neurotropic effects of heptapeptide mystixin studied on brain tissue sections].
abstract: Neurotropic effects of heptapeptide mystixin have been studied on olfactory cortex neurons in rat brain tissue sections. The application of mystixin onto brain section produced a dose-dependent inhibition of AMPA- and NMDA-receptor-dependent processes. The peptide suppressed the activity of inhibitory processes only at small doses (10, 25, and 50 mg/ml) and potentiated these processes at greater doses (100 and 250 mg/ml). These effects of mystixin are reversible: after washing, the activities of both exciting (except for NMDA-related) and inhibitory mechanisms were restored.
authors.forename: A A
authors.initials: AA
authors.lastname: Mokrushin
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D008297:Male; D008839:Microelectrodes; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D018696:Neuroprotective Agents / Q000737:chemistry / Q000494:pharmacology*; D009833:Olfactory Pathways / Q000187:drug effects; D009842:Oligopeptides / Q000737:chemistry / Q000494:pharmacology*; D009924:Organ Culture Techniques; D051381:Rats; D017208:Rats, Wistar; D018091:Receptors, AMPA / Q000037:antagonists & inhibitors; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors
chemical_list: D018696:Neuroprotective Agents; D009842:Oligopeptides; D018091:Receptors, AMPA; D016194:Receptors, N-Methyl-D-Aspartate; C110632:mystixin 7