title: Predictive factors for prolonged intubation following liver transplantation.
abstract: OBJECTIVE
  This study identified risk factors associated with prolonged intubation after living donor liver transplantation (LDLT).
  
  
  METHODS
  Out of 50 patients who underwent LDLT, clinical data were compared between those extubated within 4 days of LDLT (early group; n=20) and those extubated 5 days post-LDLT (delayed group; n=30).
  
  
  RESULTS
  Univariate analysis associated the following factors with prolonged intubation: preoperative age >48 years (p=0.05), body mass index >22 kg/m² (p=0.01), creatinine clearance <90 mL/min/1.73 m² (p=0.003), ratio between arterial oxygen tension and fractional inspired oxygen ≤375 (p=0.02) and postoperative changes of body-weight per body surface area ((BW - preoperative BW)/BSA)) on postoperative day (POD) 3 (>2.0 kg/m²) (p=0.01). Multivariate analysis showed that creatinine clearance and (BW - preoperative BW)/BSA on POD 3 remained as independent predictive factors (p=0.04 and 0.04, respectively).
  
  
  CONCLUSIONS
  We should aim for postoperative fluid management such that ((BW - preoperative BW)/BSA) ≤2.0 kg/m² on POD 3, especially in patients with low preoperative levels of creatinine clearance.
authors.affiliation: Department of Gastroenterological Surgery, Yokohama City University Graduate School of Medicine, Yokohama, Japan. kazutake@yokohama-cu.ac.jp
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Takeda
authors.forename: Kuniya
authors.initials: K
authors.lastname: Tanaka
authors.forename: Takafumi
authors.initials: T
authors.lastname: Kumamoto
authors.forename: Kazunori
authors.initials: K
authors.lastname: Nojiri
authors.forename: Ryutaro
authors.initials: R
authors.lastname: Mori
authors.forename: Koichi
authors.initials: K
authors.lastname: Taniguchi
authors.forename: Ryusei
authors.initials: R
authors.lastname: Matsuyama
authors.forename: Itaru
authors.initials: I
authors.lastname: Endo
mesh_terms: D000328:Adult; D060666:Airway Extubation; D015415:Biomarkers / Q000097:blood; D001834:Body Water / Q000378:metabolism; D016009:Chi-Square Distribution; D003404:Creatinine / Q000097:blood; D005260:Female; D005440:Fluid Therapy; D006801:Humans; D007442:Intubation, Intratracheal / Q000009:adverse effects / Q000401:mortality; D016031:Liver Transplantation / Q000009:adverse effects* / Q000401:mortality; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011182:Postoperative Care; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D003404:Creatinine