title: Brain FDG-PET changes in ALS and ALS-FTD.
abstract: BACKGROUND
  FDG-PET in ALS most typically demonstrates a primary (and sometimes also supplementary) motor cortex hypometabolism, often associated with more diffuse cortical hypometabolism involving mostly the dorsolateral prefrontal cortex, the medial and lateral premotor cortices, and the bilateral insular cortex involvement. In ALS-FTD, extensive temporal hypometabolism is seen in addition to severe diffuse frontal hypometabolism.
  
  
  METHODS
  This study analyses FDG-PET findings in 6 ALS patients and 4 ALS-FTD patients.
  
  
  RESULTS
  In addition to earlier described areas of hypometabolism in ALS, we found also reduced FDG-PET metabolism in the medial frontal cortex, the orbitofrontal cortex, and the anterior temporal lobe in our ALS patients. The anterolateral area was the best preserved part of the frontal lobe in ALS patients. In ALS-FTD, frontal and temporal hypometabolism was severe (and parietal hypometabolism was often also present) with relatively preserved perirolandic metabolism.
  
  
  CONCLUSIONS
  In ALS, more diffuse frontal and temporal FDG-PET hypometabolism was seen than earlier reported, with the anterolateral area as the best preserved part of the frontal lobe. In ALS-FTD, relatively preserved perirolandic metabolism was seen, associated with severe frontal and temporal hypometabolism.
authors.affiliation: Department of Neurology, CHU Nimes, Hôpital Caremeau, 30029 Nimes Cedex 4, France. dimitrirenard@hotmail.com
authors.forename: Dimitri
authors.initials: D
authors.lastname: Renard
authors.forename: Laurent
authors.initials: L
authors.lastname: Collombier
authors.forename: Giovanni
authors.initials: G
authors.lastname: Castelnovo
authors.forename: Genevieve
authors.initials: G
authors.lastname: Fourcade
authors.forename: Pierre-Olivier
authors.initials: PO
authors.lastname: Kotzki
authors.forename: Pierre
authors.initials: P
authors.lastname: LaBauge
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000000981:diagnostic imaging / Q000473:pathology*; D001921:Brain / Q000000981:diagnostic imaging*; D001931:Brain Mapping; D005260:Female; D019788:Fluorodeoxyglucose F18; D057180:Frontotemporal Dementia / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods*
chemical_list: D019788:Fluorodeoxyglucose F18