title: Radical-regulating and antiviral properties of ascorbic acid and its derivatives.
abstract: The ability of ascorbic acid and a number of its derivatives to suppress replication of Herpes simplex virus type I was investigated in human rhabdomyosarcoma cell line. In parallel, interaction of the test compounds with carbon- and oxygen-centered radicals formed on radiolysis of hydroxyl-containing organic compounds was studied using the steady state radiolysis method. It has been shown that 2-O-glycoside of ascorbic acid, displaying marked antiviral properties against Herpes simplex virus type I, is also capable of inhibiting fragmentation and recombination reactions of α-hydroxyl-containing carbon-centered radicals while not affecting processes involving oxygen-centered radicals.
authors.affiliation: Department of Chemistry of the Belarusian State University, Nezavisimosti Av., 4, 220030, Minsk, Belarus.
authors.forename: Sviatoslav D
authors.initials: SD
authors.lastname: Brinkevich
authors.forename: Eugene I
authors.initials: EI
authors.lastname: Boreko
authors.forename: Olga V
authors.initials: OV
authors.lastname: Savinova
authors.forename: Natalia I
authors.initials: NI
authors.lastname: Pavlova
authors.forename: Oleg I
authors.initials: OI
authors.lastname: Shadyro
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001205:Ascorbic Acid / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D002244:Carbon / Q000737:chemistry; D045744:Cell Line, Tumor; D016166:Free Radical Scavengers / Q000138:chemical synthesis* / Q000494:pharmacology; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D006801:Humans; D010100:Oxygen / Q000737:chemistry; D011839:Radiation, Ionizing; D017382:Reactive Oxygen Species / Q000378:metabolism* / Q000528:radiation effects; D012208:Rhabdomyosarcoma
chemical_list: D000998:Antiviral Agents; D016166:Free Radical Scavengers; D017382:Reactive Oxygen Species; D002244:Carbon; D001205:Ascorbic Acid; D010100:Oxygen