title: [Effect of CO(2) pneumoperitoneum on renal function in rats].
abstract: OBJECTIVE
  To evaluate the effects of different CO(2) pneumoperitoneum conditions on renal function in rats and provide experimental evidence for improving renal graft function after transplantation.
  
  
  METHODS
  SD rats were randomized into 10 groups (n=12) and subject to CO(2) pneumoperitoneum at different pressures (0.67, 1.33 and 2.0 kPa) for 60 or 120 min. Serum urea nitrogen (BUN), creatinine (Cr) and N-acetyl-β-D-glocosaminidase (NAG) levels were detected after pneumoperitoneum.
  
  
  RESULTS
  As the pressure and time of pneumoperitoneum increased, the renal function deteriorated gradually, showing significant differences between the groups (P<0.05).
  
  
  CONCLUSIONS
  Increased pressure and prolonged duration of CO(2) pneumoperitoneum causes impairment of the renal function, suggesting the necessity of reducing the operative time and lowering the pressure of pneumoperitoneum when harvesting renal graft in living donors.
authors.affiliation: Department of Urology, Guangdong Academy of Sciences, Guangzhou, China. xuzhanping2004@163.com
authors.forename: Zhanping
authors.initials: Z
authors.lastname: Xu
authors.forename: Xiaoyong
authors.initials: X
authors.lastname: Pu
authors.forename: Huanqing
authors.initials: H
authors.lastname: Yang
authors.forename: Xiangguang
authors.initials: X
authors.lastname: Zheng
authors.forename: Jiumin
authors.initials: J
authors.lastname: Liu
mesh_terms: D000818:Animals; D002245:Carbon Dioxide; D005260:Female; D007668:Kidney / Q000502:physiology*; D016030:Kidney Transplantation; D010535:Laparoscopy / Q000379:methods; D008297:Male; D009392:Nephrectomy / Q000379:methods; D011028:Pneumoperitoneum, Artificial / Q000009:adverse effects* / Q000379:methods; D051381:Rats; D017207:Rats, Sprague-Dawley; D012187:Retroperitoneal Space / Q000601:surgery; D013997:Time Factors; D020858:Tissue and Organ Harvesting / Q000379:methods*
chemical_list: D002245:Carbon Dioxide