title: Unraveling the Numerous Biosynthetic Products of the Marine Sediment-Derived Fungus, Aspergillus insulicola.
abstract: A new tripeptide, pre-sclerotiotide F (3), was isolated from a marine sediment-derived fungus, Aspergillus insulicola, along with five known compounds, one of which was new at the time of isolation, scerotiotide F (4). The absolute configuration elucidation of the new compound was determined using a combination of NMR, HR-ESI-MS, and optical rotation analyses. Cytotoxicities were measured in vitro against selected cancer cells. The effects of pre-sclerotiotide F (3) and sclerotiotide F (4) on LPS-induced NF-κB and iNOS expression were also measured.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P. R. China.
authors.forename: Q X
authors.initials: QX
authors.lastname: Wu
authors.forename: X J
authors.initials: XJ
authors.lastname: Jin
authors.forename: M
authors.initials: M
authors.lastname: Draskovic
authors.forename: M S
authors.initials: MS
authors.lastname: Crews
authors.forename: K
authors.initials: K
authors.lastname: Tenney
authors.forename: F A
authors.initials: FA
authors.lastname: Valeriote
authors.forename: X J
authors.initials: XJ
authors.lastname: Yao
authors.forename: P
authors.initials: P
authors.lastname: Crews