title: Copper(I) acetate-catalyzed azide-alkyne cycloaddition for highly efficient preparation of 1-(pyridin-2-yl)-1,2,3-triazoles.
abstract: A highly efficient copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) of 6-substituted tetrazolo[1,5-a]pyridines was developed for the preparation of 1-(pyridin-2-yl)-1,2,3-triazoles by simply using copper(I) acetate as a catalyst. The in situ formed HOAc played important dual roles and an activation of 2-azidopyridine-copper(I) complex was observed.
authors.affiliation: Department of Chemistry, Tsinghua University, Beijing 100084, PR China.
authors.forename: Qun
authors.initials: Q
authors.lastname: Zhang
authors.forename: Xinyan
authors.initials: X
authors.lastname: Wang
authors.forename: Chuanjie
authors.initials: C
authors.lastname: Cheng
authors.forename: Rui
authors.initials: R
authors.lastname: Zhu
authors.forename: Nan
authors.initials: N
authors.lastname: Liu
authors.forename: Yuefei
authors.initials: Y
authors.lastname: Hu
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D014230:Triazoles / Q000138:chemical synthesis*
chemical_list: D000480:Alkynes; D001386:Azides; D009942:Organometallic Compounds; D011725:Pyridines; D014230:Triazoles; C015092:cupric acetate; C023666:pyridine