title: Organ transplantation and skin--principles and concepts.
abstract: Solid organ transplantation influences the biology of the skin profoundly. In the wake of transplantation, inflammatory, infectious and neoplastic disorders arise, often with atypical clinical presentation. Inflammatory disorders mainly relate to pathogen-driven conditions such as seborrheic dermatitis and pityrosporum folliculitis and to drug reactions. Infectious disorders are dominated by viral infections of human papilloma virus and by infections and reactivations of herpes family members. Neoplastic disorders are greatly increased with squamous cell carcinoma of the skin as most relevant clinical problem which is increased 65- to 100-fold following transplantation. This dramatic increase in cutaneous carcinogenesis results from the isolated effect of ultraviolet light on the skin with immunosuppression and DNA damage and of immunosuppressants which drive skin cancer formation by properties unrelated to immunosuppression and from the combined effect of UV light and immunosuppressive drugs on immunomodulation which results in impaired antitumor response as well as chronic tumorigenic inflammation.
authors.affiliation: Dermatologische Klinik, Universitätsspital Zürich, Gloriastrasse 31, Zürich, Switzerland. hofbauer@usz.ch
authors.forename: Günther F L
authors.initials: GF
authors.lastname: Hofbauer
authors.forename: Sandra N
authors.initials: SN
authors.lastname: Freiberger
authors.forename: Guergana
authors.initials: G
authors.lastname: Iotzova-Weiss
authors.forename: Bahar
authors.initials: B
authors.lastname: Shafaeddin
authors.forename: Piotr J
authors.initials: PJ
authors.lastname: Dziunycz
mesh_terms: D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D016377:Organ Transplantation / Q000009:adverse effects*; D012871:Skin Diseases / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D014181:Transplantation Immunology / Q000276:immunology
chemical_list: D007166:Immunosuppressive Agents