title: Successful steroid therapy for heart failure due to myocarditis associated with primary biliary cirrhosis.
abstract: This report concerns a 65-year-old woman with primary biliary cirrhosis (PBC) featuring high titers of M2 antimitochondrial antibody who developed intractable heart failure (HF). Although the etiology is unclear, involvement of skeletal muscles has been reported with PBC as a result of mitochondrial damage from the autoimmune process. In this case, histopathological examination and (18)F-fluorodeoxy glucose-positron emission tomography imaging revealed myocarditis concomitant with myositis. The patient showed favourable response to high-dose corticosteroid administration. To the best of our knowledge, this is the first case of HF with myocarditis and polymyositis associated with asymptomatic PBC who was successfully treated with prednisolone.
authors.affiliation: Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
authors.forename: Kensuke
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Tanaka
authors.forename: Shota
authors.initials: S
authors.lastname: Yamana
authors.forename: Akihiro
authors.initials: A
authors.lastname: Kaneko
authors.forename: Takayuki
authors.initials: T
authors.lastname: Tsuji
authors.forename: Keiko
authors.initials: K
authors.lastname: Ryo
authors.forename: Kenji
authors.initials: K
authors.lastname: Sekiguchi
authors.forename: Fumi
authors.initials: F
authors.lastname: Kawakami
authors.forename: Hiroya
authors.initials: H
authors.lastname: Kawai
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Hirata
mesh_terms: D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001706:Biopsy; D004699:Endocardium / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D009205:Myocarditis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D009206:Myocardium / Q000473:pathology; D009336:Necrosis; D017285:Polymyositis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D049268:Positron-Emission Tomography; D011239:Prednisolone / Q000627:therapeutic use*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D000893:Anti-Inflammatory Agents; D011239:Prednisolone