title: Prediction of eye color from genetic data using Bayesian approach.
abstract: Prediction of visible traits from genetic data in certain forensic cases may provide important information that can speed up the process of investigation. Research that has been conducted on the genetics of pigmentation has revealed polymorphisms that explain a significant proportion of the variation observed in human iris color. Here, on the basis of genetic data for the six most relevant eye color predictors, two alternative Bayesian network model variants were developed and evaluated for their accuracy in prediction of eye color. The first model assumed eye color to be categorized into blue, brown, green, and hazel, while the second variant assumed a simplified classification with two states: light and dark. It was found that particularly high accuracy was obtained for the second model, and this proved that reliable differentiation between light and dark irises is possible based on analysis of six single nucleotide polymorphisms and a Bayesian procedure of evidence interpretation.
authors.affiliation: Section of Forensic Genetics, Institute of Forensic Research, Kraków, Poland.
authors.forename: Ewelina
authors.initials: E
authors.lastname: Pośpiech
authors.forename: Jolanta
authors.initials: J
authors.lastname: Draus-Barini
authors.forename: Tomasz
authors.initials: T
authors.lastname: Kupiec
authors.forename: Anna
authors.initials: A
authors.lastname: Wojas-Pelc
authors.forename: Wojciech
authors.initials: W
authors.lastname: Branicki
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000235:genetics; D017920:Antiporters / Q000235:genetics; D005127:Eye Color / Q000235:genetics*; D005260:Female; D053803:Forensic Genetics; D020662:Guanine Nucleotide Exchange Factors / Q000235:genetics; D006801:Humans; D050835:Interferon Regulatory Factors / Q000235:genetics; D015810:Linkage Disequilibrium; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics; D026901:Membrane Transport Proteins / Q000235:genetics; D008875:Middle Aged; D015233:Models, Statistical; D060885:Multiplex Polymerase Chain Reaction; D010088:Oxidoreductases / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D011237:Predictive Value of Tests; D011336:Probability; D012680:Sensitivity and Specificity; D017422:Sequence Analysis, DNA; D044767:Ubiquitin-Protein Ligases; D055815:Young Adult; D000099218:Interferon Regulatory Factor-4
chemical_list: D000951:Antigens, Neoplasm; D017920:Antiporters; D020662:Guanine Nucleotide Exchange Factors; D050835:Interferon Regulatory Factors; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D010088:Oxidoreductases; D044767:Ubiquitin-Protein Ligases; D000099218:Interferon Regulatory Factor-4; C489600:OCA2 protein, human; C470570:SLC24A4 protein, human; C510061:SLC45A2 protein, human; C489799:TYRP1 protein, human; C118566:HERC2 protein, human