title: The acid free asymmetric intermolecular α-alkylation of aldehydes in fluorinated alcohols.
abstract: The acid free asymmetric intermolecular α-alkylation of aldehydes with alcohols has been discovered using trifluoroethanol as solvent. This unprecedented system affords the enantioenriched functionalized primary alcohols (after NaBH(4) reduction) in high yields and good to excellent enantioselectivities with wide substrate scope in the absence of any acid additive.
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore, 637371.
authors.forename: Jian
authors.initials: J
authors.lastname: Xiao
authors.forename: Kai
authors.initials: K
authors.lastname: Zhao
authors.forename: Teck-Peng
authors.initials: TP
authors.lastname: Loh