title: Native kidney BK virus nephropathy associated with chronic lymphocytic leukaemia.
abstract: BK virus nephropathy (BKVN) is a well-recognized complication of renal transplantation. Several cases of native kidney BKVN following other solid organ or bone marrow transplants have been reported. We describe a patient with chronic lymphocytic leukaemia who presented with deteriorating renal function with no history of solid organ or bone marrow transplantation. Renal biopsy demonstrated tubular injury characteristic of viral infection, confirmed as BK virus by immunohistochemistry and elevated serum BK viral titres. Treatment with leflunomide reduced serum viral titres and stabilized renal function. This is the first biopsy-proven case of native kidney BKVN in a patient with no previous transplantation history.
authors.affiliation: Renal Unit, Ulster Hospital, Belfast, UK.
authors.forename: Richard
authors.initials: R
authors.lastname: McCrory
authors.forename: Moyra
authors.initials: M
authors.lastname: Gray
authors.forename: Niall
authors.initials: N
authors.lastname: Leonard
authors.forename: John
authors.initials: J
authors.lastname: Smyth
authors.forename: Alastair
authors.initials: A
authors.lastname: Woodman
mesh_terms: D000368:Aged; D001739:BK Virus / Q000235:genetics / Q000302:isolation & purification*; D004279:DNA, Viral / Q000235:genetics; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007555:Isoxazoles / Q000627:therapeutic use; D007674:Kidney Diseases / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D000077339:Leflunomide; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications*; D008297:Male; D016133:Polymerase Chain Reaction; D027601:Polyomavirus Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D011379:Prognosis; D014412:Tumor Virus Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology
chemical_list: D004279:DNA, Viral; D007166:Immunosuppressive Agents; D007555:Isoxazoles; D000077339:Leflunomide