title: Changes in parameters of bone metabolism in postmenopausal women following a 12-month intervention period using dairy products enriched with calcium, vitamin D, and phylloquinone (vitamin K(1)) or menaquinone-7 (vitamin K (2)): the Postmenopausal Health Study II.
abstract: The objective of the present study was to examine the effect of dairy products enriched with calcium, vitamin D(3), and phylloquinone (vitamin K(1)) or menaquinone-7 (vitamin K(2)) on parameters of bone metabolism in postmenopausal women following a 12-month intervention. Postmenopausal women were divided into three intervention groups and a control group (CG). All three intervention groups attended biweekly sessions and received fortified dairy products providing daily 800 mg of calcium and 10 μg of vitamin D(3) (CaD). Furthermore, in two of the three intervention groups the dairy products were also enriched with vitamin K, providing daily 100 μg of either phylloquinone (CaDK1) or menaquinone-7 (CaDK2). The increase observed for serum 25(OH)D levels in all intervention groups and the increase observed for serum IGF-I levels in the CaDK2 group differed significantly compared to the changes observed in CG (P = 0.010 and P = 0.028, respectively). Furthermore, both the CaDK1 and CaDK2 groups had a significantly lower mean serum undercarboxylated osteocalcin to osteocalcin ratio and urine deoxypyridinoline levels at follow-up compared to the CaD and CG groups (P = 0.001 and P = 0.047, respectively). Significant increases in total-body BMD were observed in all intervention groups compared to CG (P < 0.05), while significant increases in lumbar spine BMD were observed only for CaDK1 and CaDK2 compared to CG (P < 0.05) after controlling for changes in serum 25(OH)D levels and dietary calcium intake. In conclusion, the present study revealed more favorable changes in bone metabolism and bone mass indices for the two vitamin K-supplemented groups, mainly reflected in the suppression of serum levels of bone remodeling indices and in the more positive changes in lumbar spine BMD for these two study groups.
authors.affiliation: Department of Nutrition and Dietetics, Harokopio University, Kallithea, Athens, Greece.
authors.forename: Spyridon
authors.initials: S
authors.lastname: Kanellakis
authors.forename: George
authors.initials: G
authors.lastname: Moschonis
authors.forename: Roxane
authors.initials: R
authors.lastname: Tenta
authors.forename: Anne
authors.initials: A
authors.lastname: Schaafsma
authors.forename: Ellen G H M
authors.initials: EG
authors.lastname: van den Heuvel
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Papaioannou
authors.forename: George
authors.initials: G
authors.lastname: Lyritis
authors.forename: Yannis
authors.initials: Y
authors.lastname: Manios
mesh_terms: D000368:Aged; D015519:Bone Density / Q000187:drug effects; D050071:Bone Density Conservation Agents / Q000008:administration & dosage*; D001842:Bone and Bones / Q000378:metabolism*; D002136:Calcium, Dietary / Q000008:administration & dosage*; D003611:Dairy Products; D019587:Dietary Supplements; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000378:metabolism; D017698:Postmenopause; D014807:Vitamin D / Q000008:administration & dosage; D010837:Vitamin K 1 / Q000008:administration & dosage; D024482:Vitamin K 2 / Q000008:administration & dosage / Q000031:analogs & derivatives; D014815:Vitamins / Q000008:administration & dosage
chemical_list: D050071:Bone Density Conservation Agents; D002136:Calcium, Dietary; D014815:Vitamins; D024482:Vitamin K 2; D014807:Vitamin D; D010837:Vitamin K 1; C062629:menaquinone 7