title: Catalytic enantioselective synthesis of β-trifluoromethyl pyrrolines.
abstract: Enantioselective synthesis of β-trifluoromethylated pyrrolines has been developed by the organocatalyzed-conjugated addition of nitromethane to β-trifluoromethylated enones, followed by a nitro-reduction/cyclization/dehydration sequence in a one-pot procedure with 97-98% ees.
authors.affiliation: Department of Frontier Materials, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa-ku, Nagoya 466-8555, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kawai
authors.forename: Takashi
authors.initials: T
authors.lastname: Kitayama
authors.forename: Etsuko
authors.initials: E
authors.lastname: Tokunaga
authors.forename: Takashi
authors.initials: T
authors.lastname: Matsumoto
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Sato
authors.forename: Motoo
authors.initials: M
authors.lastname: Shiro
authors.forename: Norio
authors.initials: N
authors.lastname: Shibata
mesh_terms: D002384:Catalysis; D003500:Cyclization; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D010084:Oxidation-Reduction; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D006845:Hydrocarbons, Fluorinated; D011758:Pyrroles; C013231:pyrroline