title: Secreted miRNAs suppress atherogenesis.
abstract: Endothelial-vascular smooth muscle cell communication has a critical role in cardiovascular homeostasis and the pathogenesis of atherosclerosis. A study now demonstrates extracellular-vesicle-mediated transfer of the atheroprotective microRNAs miR-143/145 between endothelial and vascular smooth muscle cells, providing compelling evidence that intercellular transport of miRNAs can influence a pathological process, namely atherosclerosis.
authors.affiliation: Cardiovascular Institute and the Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Perelman School of Medicine, 11-125 Translational Research Center, Philadelphia, Philadelphia 19104-5156, USA. rader@mail.med.upenn.edu
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Rader
authors.forename: Michael S
authors.initials: MS
authors.lastname: Parmacek
mesh_terms: D000818:Animals; D042783:Endothelial Cells / Q000378:metabolism*; D006801:Humans; D051741:Kruppel-Like Transcription Factors / Q000235:genetics*; D035683:MicroRNAs / Q000235:genetics*; D032389:Myocytes, Smooth Muscle / Q000378:metabolism*
chemical_list: C096161:KLF2 protein, human; D051741:Kruppel-Like Transcription Factors; C542359:MIRN143 microRNA, human; C541010:MIRN145 microRNA, human; D035683:MicroRNAs