title: Wiskott-Aldrich syndrome; an x-linked primary immunodeficiency disease with unique and characteristic features.
abstract: Wiskott-Aldrich syndrome (WAS) is an X-linked primary immunodeficiency disease with unique and characteristic features. In 1994, the responsible gene for WAS, the WASP gene on X-chromosome, was identified. Since then, renewed clinical and basic researches of WAS have started and remarkably developed. I will comment on recent progress in the clinical and basic researches of WAS, including some topics reported by our and other groups.
authors.affiliation: Department of Pediatrics, Hokkaido University Graduate School of Medicine, Hokkaido, Japan. tada−ari@med.hokudai.ac.jp
authors.forename: Tadashi
authors.initials: T
authors.lastname: Ariga
mesh_terms: D000818:Animals; D004485:Eczema / Q000276:immunology; D050172:Genes, X-Linked / Q000235:genetics / Q000276:immunology; D015316:Genetic Therapy; D018380:Hematopoietic Stem Cell Transplantation; D006470:Hemorrhage / Q000276:immunology; D006801:Humans; D007109:Immunity / Q000235:genetics; D007231:Infant, Newborn; D008297:Male; D009154:Mutation / Q000235:genetics; D013921:Thrombocytopenia / Q000276:immunology; D014923:Wiskott-Aldrich Syndrome / Q000175:diagnosis* / Q000235:genetics* / Q000276:immunology; D051316:Wiskott-Aldrich Syndrome Protein / Q000235:genetics / Q000378:metabolism*
chemical_list: D051316:Wiskott-Aldrich Syndrome Protein