title: Predicting survival in chronic lymphocytic leukemia.
abstract: There is increasing interest in the use of prognostic markers that may predict survival and guide management in patients diagnosed with the early stages of chronic lymphocytic leukemia (CLL). Currently, the most important traditional prognostic factors include clinical staging, lymphocyte doubling time and β2-microglobulin/thymidine kinase; and the most important novel markers include karyotypic aberrations (typically assessed by FISH probes or CpG oligonucleotide karyotyping) and IgVH mutation status. Although each of these factors have individually shown significant correlations with survival, there is increasing appreciation that the most complete information may be obtained by using a combination of several factors in prognostic normograms or models. In this article, we review the current state-of-the-art with regards to CLL prognostic factors and discuss how they can be applied in the clinic.
authors.affiliation: Hematology Department, St Vincent's Hospital, Melbourne, VIC, Australia.
authors.forename: Ali
authors.initials: A
authors.lastname: Bazargan
authors.forename: Constantine S
authors.initials: CS
authors.lastname: Tam
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Keating
mesh_terms: D059786:Abnormal Karyotype; D014408:Biomarkers, Tumor; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D007155:Immunologic Factors / Q000235:genetics; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood / Q000235:genetics / Q000401:mortality / Q000473:pathology; D018655:Lymphocyte Count; D054539:Medication Therapy Management; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D009838:Oligodeoxyribonucleotides / Q000235:genetics*; D011237:Predictive Value of Tests; D011379:Prognosis; D015996:Survival Rate; D013937:Thymidine Kinase / Q000378:metabolism*; D013997:Time Factors; D001613:beta 2-Microglobulin / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; C408982:CPG-oligonucleotide; D007143:Immunoglobulin Heavy Chains; D007155:Immunologic Factors; D009838:Oligodeoxyribonucleotides; D001613:beta 2-Microglobulin; D013937:Thymidine Kinase