title: New insights into the versatile roles of platelet FlnA.
abstract: Recent findings have identified critical roles for the actin filament-crosslinking protein filamin A (FlnA) in platelets and megakaryocytes. This short review focuses on the structure of FlnA and its interaction with the Von Willebrand Factor receptor GPIb-IX-V complex and the fibrinogen receptor, the integrin αIIbβ3 in platelets.
authors.affiliation: Division of Translational Medicine, Brigham and Women's Hospital, Department of Medicine, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Hervé
authors.initials: H
authors.lastname: Falet
mesh_terms: D001792:Blood Platelets / Q000378:metabolism*; D002352:Carrier Proteins; D003285:Contractile Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D064448:Filamins; D006801:Humans; D008840:Microfilament Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D009154:Mutation; D011485:Protein Binding; D013921:Thrombocytopenia / Q000235:genetics / Q000378:metabolism
chemical_list: D002352:Carrier Proteins; D003285:Contractile Proteins; D064448:Filamins; D008840:Microfilament Proteins