title: Relationship of oxidative stress in hepatitis B infection activity with HBV DNA and fibrosis.
abstract: BACKGROUND
  The aim of this study was to evaluate oxidative stress in various clinical forms of hepatitis B infection and to investigate its role in the development of the chronic form of the disease.
  
  
  METHODS
  Ninety-three patients with inactive hepatitis B surface antigen (HbsAg) carrier state (IHBCS), 65 patients with chronic hepatitis B infection (CHB), and 42 healthy adults were included in the study. The following values were measured and compared in patient groups: total antioxidant status (TAS), total oxidative stress (TOS), oxidative stress index (OSI), sulfhydryl (SH), lipid peroxidation (LOOH), catalase (CAT), and ceruloplasmin. In patients with chronic hepatitis B, these values were compared with HBV DNA and fibrosis levels.
  
  
  RESULTS
  ALT, TOS, LOOH, and OSI levels were higher in the CHB group compared to the other groups (P<0.001). Catalase levels increased in the CHB and IHBCS groups compared to the control group (P<0.001). Total aminooxidant and ceruloplasmin levels were found to be lowest in the CHB group and highest in the control group (P<0.001). Sulfhyrdyl was higher in the control group compared to the other groups (P<0.001). In the CHB group, there was no correlation between the HBV DNA and OSI (P>0.05).
  
  
  CONCLUSIONS
  These finding suggested that oxidative stress is associated with hepatitis B activity.
authors.affiliation: Department of Infectious Disease and Clinic Microbiology, Tokat State Hospital, Tokat, Turkey. drfduygu@gmail.com
authors.forename: Fazilet
authors.initials: F
authors.lastname: Duygu
authors.forename: Hasan
authors.initials: H
authors.lastname: Karsen
authors.forename: Nurten
authors.initials: N
authors.lastname: Aksoy
authors.forename: Abdullah
authors.initials: A
authors.lastname: Taskin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D000975:Antioxidants / Q000378:metabolism; D002353:Carrier State; D002374:Catalase / Q000097:blood; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D005355:Fibrosis; D006509:Hepatitis B / Q000378:metabolism* / Q000473:pathology; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006515:Hepatitis B virus / Q000235:genetics*; D019694:Hepatitis B, Chronic / Q000378:metabolism / Q000473:pathology; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D013438:Sulfhydryl Compounds / Q000097:blood; D055815:Young Adult
chemical_list: D000975:Antioxidants; D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens; D013438:Sulfhydryl Compounds; D002374:Catalase; D000410:Alanine Transaminase