title: Facile synthesis of 4-substituted 3,4-dihydrocoumarins via an organocatalytic double decarboxylation process.
abstract: 3,4-Dihydrocoumarins, considered to be valuable building blocks, have attracted considerable attention due to their various biological activities. Herein, we have documented an efficient and convenient double decarboxylation process for the synthesis of 4-substituted 3,4-dihydrocoumarin in moderate to excellent yields under mild reaction conditions (up to 98%).
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543.
authors.forename: Shiyong
authors.initials: S
authors.lastname: Peng
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Haibing
authors.initials: H
authors.lastname: Guo
authors.forename: Shaofa
authors.initials: S
authors.lastname: Sun
authors.forename: Jian
authors.initials: J
authors.lastname: Wang
mesh_terms: D001688:Biological Products / Q000737:chemistry; D002384:Catalysis; D003374:Coumarins / Q000138:chemical synthesis*; D003500:Cyclization; D003653:Decarboxylation; D015394:Molecular Structure
chemical_list: D001688:Biological Products; D003374:Coumarins; C026308:3,4-dihydrocoumarin