title: Short communication: Association of an OLR1 polymorphism with milk production traits in the Israeli Holstein population.
abstract: Previous studies have reported significant associations between haplotypes of the oxidized low-density lipoprotein (lectin-like) receptor 1 (OLR1) gene and a single nucleotide polymorphism (SNP) in its 3'-untranslated region with milk composition and health traits in different cattle populations. However, to provide a better estimation of the impact and size of the association of OLR1 with production traits, a need exists to validate its genomic association in additional cattle populations. Thus, the objective of this study was to perform association analysis of the OLR1 SNP with milk traits in the Israeli Holstein population. Estimated breeding values of milk composition traits and somatic cell score were obtained for a total of 1,211 Holstein cows, which were genotyped for a SNP in the 3'-untranslated region. Statistical analysis revealed significant association between the OLR1 SNP and protein percentage and somatic cell score. Thus, the validation of association of this SNP with milk traits in independent cattle populations suggests OLR1 as a candidate gene for further functional studies.
authors.affiliation: College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, PR China.
authors.forename: X
authors.initials: X
authors.lastname: Wang
authors.forename: F
authors.initials: F
authors.lastname: Peñagaricano
authors.forename: R
authors.initials: R
authors.lastname: Tal-Stein
authors.forename: E
authors.initials: E
authors.lastname: Lipkin
authors.forename: H
authors.initials: H
authors.lastname: Khatib
mesh_terms: D020413:3' Untranslated Regions / Q000235:genetics; D000818:Animals; D002417:Cattle / Q000235:genetics; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D007557:Israel; D007774:Lactation / Q000235:genetics*; D008892:Milk / Q000737:chemistry / Q000166:cytology / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D051127:Scavenger Receptors, Class E / Q000235:genetics*
chemical_list: D020413:3' Untranslated Regions; D051127:Scavenger Receptors, Class E