title: Successful long-term treatment of cerebral nocardiosis with unexpectedly low doses of linezolid in an immunocompromised patient receiving complex polytherapy.
abstract: Cerebral nocardiosis is a severe infection that carries the highest mortality rate among all bacterial cerebral abscesses. We report on a case in an immunocompromised patient which was successfully treated with unexpectedly low doses of linezolid. Therapeutic drug monitoring was very helpful in highlighting issues of poor compliance and of drug-drug interactions.
authors.affiliation: Department of Experimental and Clinical Medical Sciences, Institute of Clinical Pharmacology, Azienda Ospedaliero-Universitaria Santa Maria della Misericordia, Medical School, University of Udine, Udine, Italy. pea.federico@aoud.sanita.fvg.it
authors.forename: Federico
authors.initials: F
authors.lastname: Pea
authors.forename: Piergiorgio
authors.initials: P
authors.lastname: Cojutti
authors.forename: Alberto
authors.initials: A
authors.lastname: Pagotto
authors.forename: Francesco
authors.initials: F
authors.lastname: Cristini
authors.forename: Mario
authors.initials: M
authors.lastname: Furlanut
authors.forename: Pierluigi
authors.initials: P
authors.lastname: Viale
mesh_terms: D000081:Acetamides / Q000008:administration & dosage / Q000627:therapeutic use*; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001922:Brain Abscess / Q000188:drug therapy*; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D000069349:Linezolid; D009617:Nocardia Infections / Q000188:drug therapy*; D023303:Oxazolidinones / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D000069349:Linezolid