title: Hormonal evaluation in premature ejaculation.
abstract: BACKGROUND
  Premature ejaculation (PE) is a frequently encountered sexual dysfunction in men. It significantly impairs quality of life of the affected male and his partner. The aim of this study is to investigate the role of hormonal factors in patients with PE.
  
  
  METHODS
  107 male patients aged between 26 and 64 years (mean 45.1 ± 10.36) who consulted our outpatient clinics with complaints of PE and 94 healthy males (48.1 ± 11.81 years) as a control group were included in the study.
  
  
  RESULTS
  When mean serum hormone concentrations of both groups were compared, levels of prolactin and free T4 were found to be significantly higher in the PE group relative to the control group (p < 0.05). At least one of the hormonal parameters was abnormal in 36 cases (33.6%) with PE, compared to only 22 (23.4%) of the controls. The number of hyperprolactinemic cases was found to be significantly increased in the PE group (p < 0.05).
  
  
  CONCLUSIONS
  We feel that during the evaluation of this problem, which affects great numbers of men and their partners throughout the world, consideration of potential effects of hormonal factors might be beneficial.
authors.affiliation: Department of Urology, Haydarpasa Numune Training and Research Hospital, Istanbul, Turkey.
authors.forename: Metin İshak
authors.initials: Mİ
authors.lastname: Oztürk
authors.forename: Orhan
authors.initials: O
authors.lastname: Koca
authors.forename: Murat
authors.initials: M
authors.lastname: Tüken
authors.forename: Muzaffer Oğuz
authors.initials: MO
authors.lastname: Keleş
authors.forename: Abdullah
authors.initials: A
authors.lastname: Ilktaç
authors.forename: M Ihsan
authors.initials: MI
authors.lastname: Karaman
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D004542:Ejaculation; D043373:Follicle Stimulating Hormone, Human / Q000097:blood; D006728:Hormones / Q000097:blood*; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008875:Middle Aged; D011388:Prolactin / Q000097:blood; D012735:Sexual Dysfunction, Physiological / Q000097:blood / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D011795:Surveys and Questionnaires; D013739:Testosterone / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood; D014421:Turkey; D015854:Up-Regulation; D055815:Young Adult
chemical_list: D015415:Biomarkers; D043373:Follicle Stimulating Hormone, Human; D006728:Hormones; D014284:Triiodothyronine; D013739:Testosterone; D011388:Prolactin; D007986:Luteinizing Hormone; D013974:Thyroxine