title: [Effects of jingqianshu granule on expression of 5-HT(1A)R of PMS model rats with liver-qi stagnation].
abstract: OBJECTIVE
  To research the effect of the Jingqianshu granule (JQS) on the expression of serotonin receptor-1A (5-HT(1A)R) in hippocampus and hypothalamus of premenstrual syndrome (PMS) model rats with Liver-qi depression.
  
  
  METHODS
  The PMS model rats with Liver-qi depression were induced by bandaging the limbs. The model rats were treated with JQS, and evaluated by open-field test. The expression of 5-HT(1A)R in hippocampus and hypothalamus was analysed by the method of RT-PCR and Western blot.
  
  
  RESULTS
  After the JQS were administered, the open field scores, the expression of 5-HT(1A)R mRNA and protein in hippocampus and hypothalamus of rats increased significantly.
  
  
  CONCLUSIONS
  The JQS granule can up-regulate the expression of 5-HT(1A)R in hippocampus and hypothalamus, which maybe one of the mechanism to treat PMS with liver-qi depression.
authors.affiliation: Laboratory of Traditional Chinese Medicine Classical Theory, Shandong University of Traditional Chinese Medicine, Ji'nan 250355, China. suyunxiangben@hotmail.com
authors.forename: Yunxiang
authors.initials: Y
authors.lastname: Su
authors.forename: Ling
authors.initials: L
authors.lastname: Xue
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D008107:Liver Diseases / Q000188:drug therapy* / Q000378:metabolism; D011293:Premenstrual Syndrome / Q000188:drug therapy* / Q000378:metabolism; D019413:Qi; D051381:Rats; D044282:Receptor, Serotonin, 5-HT1A / Q000032:analysis*
chemical_list: D004365:Drugs, Chinese Herbal; D044282:Receptor, Serotonin, 5-HT1A