title: Suppression of DNA damage in human peripheral blood lymphocytes by a juice concentrate: a randomized, double-blind, placebo-controlled trial.
abstract: Chronic inflammation contributes to many prevalent diseases worldwide, and it is widely accepted that inflammatory molecules contribute to DNA damage. In this ancillary study, we investigated the influence of an encapsulated fruit and vegetable juice powder concentrate on peripheral blood lymphocytes (PBL) DNA damage. Using a double-blind, placebo-controlled approach, subjects were randomly assigned capsules containing placebo, or one of two formulations of the juice powder. Blood was drawn at baseline and after 60 days of capsule consumption. We found DNA damage in isolated PBL is suppressed after consumption of the encapsulated juice powder, and damage was correlated with the level of systemic inflammation. These data suggest a potential health benefit by consuming the juice concentrate capsules through their ability to suppress DNA damage as measured in surrogate tissues (PBL).
authors.affiliation: Department of Pharmaceutical and Biomedical Sciences, South Carolina College of Pharmacy, University of South Carolina, Columbia, SC 29205, USA.
authors.forename: Xiangli
authors.initials: X
authors.lastname: Cui
authors.forename: Yu
authors.initials: Y
authors.lastname: Jin
authors.forename: Udai P
authors.initials: UP
authors.lastname: Singh
authors.forename: Alexander A
authors.initials: AA
authors.lastname: Chumanevich
authors.forename: Brook
authors.initials: B
authors.lastname: Harmon
authors.forename: Philip
authors.initials: P
authors.lastname: Cavicchia
authors.forename: Anne B
authors.initials: AB
authors.lastname: Hofseth
authors.forename: Venkata
authors.initials: V
authors.lastname: Kotakadi
authors.forename: Deepak
authors.initials: D
authors.lastname: Poudyal
authors.forename: Brandy
authors.initials: B
authors.lastname: Stroud
authors.forename: Suresh R
authors.initials: SR
authors.lastname: Volate
authors.forename: Thomas G
authors.initials: TG
authors.lastname: Hurley
authors.forename: James R
authors.initials: JR
authors.lastname: Hebert
authors.forename: Lorne J
authors.initials: LJ
authors.lastname: Hofseth
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage*; D001628:Beverages; D015415:Biomarkers / Q000097:blood; D018932:Chemokine CCL2 / Q000235:genetics / Q000378:metabolism; D002908:Chronic Disease; D004249:DNA Damage / Q000187:drug effects*; D019587:Dietary Supplements; D004311:Double-Blind Method; D023381:Endpoint Determination; D005260:Female; D005500:Follow-Up Studies; D005638:Fruit; D006801:Humans; D007249:Inflammation / Q000628:therapy; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D018977:Micronutrients / Q000097:blood; D013482:Superoxide Dismutase / Q000187:drug effects; D014675:Vegetables; D055815:Young Adult
chemical_list: D000975:Antioxidants; D015415:Biomarkers; C111835:CCL2 protein, human; D018932:Chemokine CCL2; D018977:Micronutrients; D013482:Superoxide Dismutase