title: Five novel locations of Neocentromeres in human: 18q22.1, Xq27.1∼27.2, Acro p13, Acro p12, and heterochromatin of unknown origin.
abstract: Since the first report in 1993, an ectopic centromere, i.e. neocentromere formation, has been reported in more than 100 small supernumerary marker chromosomes (sSMC), in 7 instances of centromere repositioning, and in about a dozen cases with more complex chromosomal rearrangements. Here we report 2 new cases with centromere repositioning and 3 neocentric sSMC consisting exclusively of heterochromatic material. Yet, no centromere formation was reported for the regions 18q22.1 and Xq27.1∼27.2 as it was observed in the 2 cases with centromere repositioning here; in both cases, cytogenetically an inversion was suggested. Two of the 3 neocentric sSMC were derived from a short arm of an acrocentric chromosome. The remainder neocentric sSMC case was previously reported and was stainable only by material derived from itself.
authors.affiliation: Institute of Human Genetics, Jena University Hospital, Friedrich Schiller University, Jena, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Klein
authors.forename: M
authors.initials: M
authors.lastname: Rocchi
authors.forename: A
authors.initials: A
authors.lastname: Ovens-Raeder
authors.forename: N
authors.initials: N
authors.lastname: Kosyakova
authors.forename: A
authors.initials: A
authors.lastname: Weise
authors.forename: M
authors.initials: M
authors.lastname: Ziegler
authors.forename: M
authors.initials: M
authors.lastname: Meins
authors.forename: S
authors.initials: S
authors.lastname: Morlot
authors.forename: W
authors.initials: W
authors.lastname: Fischer
authors.forename: M
authors.initials: M
authors.lastname: Volleth
authors.forename: A
authors.initials: A
authors.lastname: Polityko
authors.forename: C Mackie
authors.initials: CM
authors.lastname: Ogilvie
authors.forename: C
authors.initials: C
authors.lastname: Kraus
authors.forename: T
authors.initials: T
authors.lastname: Liehr
mesh_terms: D000328:Adult; D002503:Centromere; D002887:Chromosomes, Human, Pair 18; D041321:Chromosomes, Human, X; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D008297:Male; D011247:Pregnancy