title: Long-term effects in ovaries of the adult mice following exposure to monosodium glutamate during neonatal life--a histological study.
abstract: Monosodium Glutamate (MSG) has been in use since long as a flavour enhancing substance. Its widespread use has also earned it a bad name to be harmful for human health. It had been incriminated in wide range of effects comprising retinal degeneration, metabolic disorders, endocrinal disorders including reduced fertility rate in both in both sexes in mice. However there were many contradicting views too, which have prompted us to undertake the present study. For our study eight female newborns of Swiss Albino mice were injected subcutaneously with MSG (2mg / gm of body wt. in a dilution 40 mg of per ml. of distilled water) on completion of 2nd, 4th, 6th, 8th and 10th day of life. Another five mice pups were injected with same volume of distilled water and taken as control. On completion of 75 days the mice were sacrificed of, ovaries were collected through dissection, 5 micron thick sections were cut and stained by H and E and PAS stain and studied under light microscope. It was observed from the quantitative analysis of the ovarian tissue that there was increase in the number of the primary follicle without increase in number of Graffian follicle in the experimental group.
authors.affiliation: Department of Anatomy, Agartala Govt. Medical College, Agartala, Tripura, India. mailme_rajatsubhradas@rediffmail.com
authors.forename: R S
authors.initials: RS
authors.lastname: Das
authors.forename: S K
authors.initials: SK
authors.lastname: Ghosh
mesh_terms: D000818:Animals; D005260:Female; D005503:Food Additives / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D006080:Ovarian Follicle / Q000187:drug effects; D010053:Ovary / Q000187:drug effects*; D012970:Sodium Glutamate / Q000494:pharmacology*
chemical_list: D005503:Food Additives; D012970:Sodium Glutamate