title: Preparation of strongly fluorescent silica nanoparticles of polyelectrolyte-protected cadmium telluride quantum dots and their application to cell toxicity and imaging.
abstract: Based on the polyelectrolyte-protected CdTe quantum dots (QDs), which were prepared by self-assembling of QDs and poly-diallyldimethylammonium chloride (PDADMAC) in the help of electrostatic attraction, the strong fluorescence silica nanoparticles (QDs-PDADMAC@SiO(2)) have been prepared via a water-in-oil reverse microemulsion method. Transmission electron microscopy and Zeta potential analysis were used to characterize the as-prepared nanoparticles. All of the particles were almost spherical and there is a uniform distribution of the particle size with the average diameter about 25 nm. There is a large Zeta potential of -35.07 mV which is necessary for good monodispersity of nanoparticles solution. As compared with the QDs coated by SiO(2) (QDs@SiO(2)), the QDs-PDADMAC@SiO(2) nanoparticles have much stronger fluorescence, and their fluorescence stability could be obviously improved. Moreover, QDs-PDADMAC@SiO(2) exhibits good biological compatibility which promotes their application in cellular imaging.
authors.affiliation: College of Pharmaceutical Science, Soochow University, Suzhou 215123, PR China.
authors.forename: Jian-hua
authors.initials: JH
authors.lastname: Tang
authors.forename: Lian
authors.initials: L
authors.lastname: Xie
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
authors.forename: Ting
authors.initials: T
authors.lastname: Qiu
authors.forename: Bin
authors.initials: B
authors.lastname: Qi
authors.forename: Hong-ping
authors.initials: HP
authors.lastname: Xie
mesh_terms: D019187:Cadmium Compounds / Q000737:chemistry*; D045744:Cell Line, Tumor; D004573:Electrolytes / Q000737:chemistry*; D004655:Emulsions / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry; D006801:Humans; D008856:Microscopy, Fluorescence; D053758:Nanoparticles / Q000737:chemistry* / Q000633:toxicity / Q000648:ultrastructure; D009821:Oils / Q000737:chemistry; D010316:Particle Size; D011095:Polyethylenes / Q000737:chemistry; D045663:Quantum Dots; D000644:Quaternary Ammonium Compounds / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry*; D055672:Static Electricity; D013691:Tellurium / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D019187:Cadmium Compounds; D004573:Electrolytes; D004655:Emulsions; D005456:Fluorescent Dyes; D009821:Oils; D011095:Polyethylenes; D000644:Quaternary Ammonium Compounds; D014867:Water; C041004:poly-N,N-dimethyl-N,N-diallylammonium chloride; D012822:Silicon Dioxide; D013691:Tellurium; C028337:cadmium telluride