title: [Safety assessment of nanomaterials in reproductive developmental field].
abstract: A diverse array of nanomaterials (NMs) such as amorphous nanosilica and carbon nanotubes have become widespread in use due to the development of nanotechnology. NMs are already being applied in universal fields because they have unique physicochemical properties. On the other hand, the increasing use of NMs has raised public concern about their potential risks to human health. In particular, recent reports indicated that carbon nanotubes induced mesothelioma-like lesions in mice, in a way similar to those induced by crocidolite asbestos. However, current knowledge of the potential risk of nanomaterials is considered insufficient. Because NMs have the potential to improve the quality of human life, it is essential to ensure the safety of NMs and provide information for designing NMs with safety. Especially, few studies have examined the effect of NMs on maintenance of pregnancy. Similar to the cases of thalidomide, a lot of evidence shows that fetuses are affected more than adults by a variety of environmental toxins because of physiological immaturity. Therefore it is essential to examine the effect of NMs on fetuses and pregnancies. Here we introduce the potential risk of amorphous nanosilica, most widely used NMs in food and the cosmetics field, to induce fetotoxicity and useful information for developing NMs with safety.
authors.affiliation: The Center for Advanced Medical Engineering and Informatics, Osaka University, Suita, Japan.
authors.forename: Kohei
authors.initials: K
authors.lastname: Yamashita
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Yoshioka
mesh_terms: D000818:Animals; D005260:Female; D005333:Fetus / Q000187:drug effects*; D006801:Humans; D051379:Mice; D053758:Nanoparticles / Q000633:toxicity; D049329:Nanostructures / Q000633:toxicity*; D037742:Nanotubes, Carbon / Q000633:toxicity; D010316:Particle Size; D011247:Pregnancy / Q000187:drug effects*; D012098:Reproduction / Q000187:drug effects*; D012449:Safety; D012822:Silicon Dioxide / Q000493:pharmacokinetics / Q000633:toxicity*
chemical_list: D037742:Nanotubes, Carbon; D012822:Silicon Dioxide