title: Polymorphisms in the vitamin D receptor gene and type 1 diabetes mellitus risk: an update by meta-analysis.
abstract: Four well known polymorphisms (BsmI, FokI, ApaI, TaqI) in the VDR gene have been implicated in susceptibility to type 1 diabetes mellitus (T1DM), but the results to date have been inconclusive. The aim of this study was to investigate the association between polymorphisms in the VDR gene and T1DM risk by meta-analysis. A total of 57 case-control studies in 26 published studies were included. The results indicated that the BsmI polymorphism is associated with increased risk of T1DM (BB+Bb vs. bb: OR=1.30, 95% CI=1.03-1.63), while the FokI, ApaI and TaqI polymorphisms were not. In the subgroup analysis by ethnicity, the increased risk of T1DM remained in the Asian subgroup for the BsmI polymorphism; whereas no significant association was found in other populations for other polymorphisms. Results from the current study suggest that the BsmI polymorphism is associated with increased risk of T1DM, especially in Asians. Further studies are needed to confirm our results.
authors.affiliation: Key Laboratory of Laboratory Medicine, Ministry of Education, Zhejiang Provincial Key Laboratory of Medical Genetics, Wenzhou Medical College, Wenzhou, Zhejiang 325035, China.
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Jiaming
authors.initials: J
authors.lastname: Liu
authors.forename: Wenhe
authors.initials: W
authors.lastname: Wu
authors.forename: Houxian
authors.initials: H
authors.lastname: Ouyang
authors.forename: Qingqing
authors.initials: Q
authors.lastname: Zhang
authors.forename: Yue
authors.initials: Y
authors.lastname: Wang
authors.forename: Libin
authors.initials: L
authors.lastname: Liu
authors.forename: Rongrong
authors.initials: R
authors.lastname: Yang
authors.forename: Xiaoting
authors.initials: X
authors.lastname: Liu
authors.forename: Qinghe
authors.initials: Q
authors.lastname: Meng
authors.forename: Jianxin
authors.initials: J
authors.lastname: Lu
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D016206:Databases, Bibliographic; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D004720:Endonucleases / Q000235:genetics; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D018167:Receptors, Calcitriol / Q000235:genetics*; D012306:Risk; D044465:White People / Q000235:genetics*
chemical_list: D018167:Receptors, Calcitriol; D004720:Endonucleases