title: Bactericidal activity of multiple combinations of tigecycline and colistin against NDM-1-producing Enterobacteriaceae.
abstract: The interaction between colistin and tigecycline against eight well-characterized NDM-1-producing Enterobacteriaceae strains was studied. Time-kill methodology was employed using a 4-by-4 exposure matrix with pharmacokinetically achievable free drug peak, trough, and average 24-h serum concentrations. Colistin sulfate and methanesulfonate alone showed good early bactericidal activity, often with subsequent regrowth. Tigecycline alone had poor activity. Addition of tigecycline to colistin does not produce increased bacterial killing; instead, it may cause antagonism at lower concentrations.
authors.affiliation: Bristol Centre for Antimicrobial Research and Evaluation, Department of Medical Microbiology, North Bristol NHS Trust, Southmead Hospital, Westbury-on-Trym, Bristol, United Kingdom. msalbur@hotmail.com
authors.forename: Mahableshwar
authors.initials: M
authors.lastname: Albur
authors.forename: Alan
authors.initials: A
authors.lastname: Noel
authors.forename: Karen
authors.initials: K
authors.lastname: Bowker
authors.forename: Alasdair
authors.initials: A
authors.lastname: MacGowan
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003091:Colistin / Q000494:pharmacology*; D004336:Drug Antagonism; D024901:Drug Resistance, Multiple, Bacterial; D004755:Enterobacteriaceae / Q000187:drug effects* / Q000201:enzymology*; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000031:analogs & derivatives* / Q000494:pharmacology; D000078304:Tigecycline; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D000078304:Tigecycline; D001618:beta-Lactamases; D008911:Minocycline; D003091:Colistin