title: A locally aggressive solitary fibrous tumor of the leg: Case report and literature review.
abstract: BACKGROUND
  The solitary fibrous tumor (SFT) is a rare soft tissue tumor with a substantially benign clinical behavior. However, malignant neoplasms with local recurrence or distant metastases have been reported.
  
  
  METHODS
  The authors present a case of an aggressive SFT of the leg, in a 55 years old Caucasian man. Radiological, histological and molecular findings are reported. The differential diagnosis, therapy and outcome of this rare tumor are also discussed.
  
  
  CONCLUSIONS
  An extensive review of literature showed SFT's clinical behavior as substantially benign, anyway aggressive or malignant neoplasms have been described. The potential risk of local recurrence and distant metastasis thus suggests wide surgical resection and careful long-term follow-up. Differential diagnosis may be quite laborious as SFT can mimic a variety of benign and malignant mesenchymal tumors; immunohistochemical analysis for CD34, CD99, vimentin and bcl-2 is then mandatory.
  
  
  CONCLUSIONS
  Our clinical experience confirmed that SFT may have an aggressive behavior, however, conservative surgical treatment may be successful in the long term.
authors.affiliation: Campus Bio-Medico University of Rome, Division of Plastic and Reconstructive Surgery, Via Alvaro del Portillo 200, 00128 Rome, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Tenna
authors.forename: I
authors.initials: I
authors.lastname: Poccia
authors.forename: B
authors.initials: B
authors.lastname: Cagli
authors.forename: A
authors.initials: A
authors.lastname: Aveta
authors.forename: M J
authors.initials: MJ
authors.lastname: Manzo
authors.forename: P
authors.initials: P
authors.lastname: Persichetti