title: Meta-analysis of cytochrome P4501A1 MspI gene polymorphism and childhood acute leukemia.
abstract: OBJECTIVE
  To investigate the relationship between cytochrome P4501A1 (CYP1A1) Msp I gene polymorphism and childhood acute leukemia (AL).
  
  
  METHODS
  Relevant literature was extensively searched and screened by Pubmed and Wanfang Database, Chinese Science Journal Database and Chinese Journal Net. Various data consolidation, combined OR values and their 95% CI were tested by RevMan 4.2; Funnel plots were used for the bias analysis.
  
  
  RESULTS
  Six related literatures were found to meet the requirements. According to heterogeneity results, there was no significant difference in homozygous types(P>0.05), while there was significant difference in two others types (P all<0.05). For wild CYP1A1MspI homozygous for the reference group, Combined OR of heterozygous mutation, homozygous, heterozygous + homozygous mutation in AL and control groups were 1.18, 0.96, and 1.10 respectively. Subgroup analysis: Z values of CYP1A1MspI homozygous, heterozygous + homozygous in the acute lymphoblastic leukemia (ALL) and the control group were 0.10 and 0.76 respectively, Z values in non-acute lymphoblastic leukemia and control group were 0.74 and 0.75.
  
  
  CONCLUSIONS
  There is no correlation between CYP1A1MspI gene polymorphism and the susceptibility of childhood AL.
authors.affiliation: Department of Endocrinology, Zhengzhou Children's Hospital, Zhengzhou 450053, Henan, China.
authors.forename: Yao Dong
authors.initials: YD
authors.lastname: Zhang
authors.forename: Li Na
authors.initials: LN
authors.lastname: Tan
authors.forename: Xiao Ling
authors.initials: XL
authors.lastname: Zhang
authors.forename: Hai Yan
authors.initials: HY
authors.lastname: Wei
authors.forename: Hao
authors.initials: H
authors.lastname: Xiong
authors.forename: Qun
authors.initials: Q
authors.lastname: Hu
mesh_terms: D000208:Acute Disease; D002648:Child; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006579:Heterozygote; D006801:Humans; D007938:Leukemia / Q000201:enzymology* / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: C569463:CYP1A1 protein, human; D019363:Cytochrome P-450 CYP1A1