title: Mitoxantrone as a prospective photosensitizer for photodynamic therapy of breast cancer.
abstract: Photodynamic therapy has the potential to become an effective alternate to surgery for the treatment of cancer. In recent years, there has been a focus on identifying more effective and less toxic photosentisizers for use in photodynamic therapy. The purpose of this study was to assess the effectiveness of mitoxantrone, a chemotherapeutic agent, as a photosensitizer for photodynamic therapy in the MCF-7 human breast cancer cell line. Cytotoxicity was evaluated for different concentrations of mitoxantrone, and photosensitivity was assessed using a non-coherent light source. The percentage of the cell survival after 24 h was investigated using the MTT assay. Overall, the results showed that mitoxantrone is a remarkably efficient photosensitizer that could mediate MCF-7 cell death at a low concentration (5 μM) with modest exposure to light. It is surprising to find that a chemotherapeutic agent can be an effective photosensitizer for PDT in vitro.
authors.affiliation: Department of Medical Physics, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Ali-Reza
authors.initials: AR
authors.lastname: Montazerabadi
authors.forename: Ameneh
authors.initials: A
authors.lastname: Sazgarnia
authors.forename: Mohammad Hossein
authors.initials: MH
authors.lastname: Bahreyni-Toosi
authors.forename: Amirhossein
authors.initials: A
authors.lastname: Ahmadi
authors.forename: Ali
authors.initials: A
authors.lastname: Shakeri-Zadeh
authors.forename: Amir
authors.initials: A
authors.lastname: Aledavood
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000494:pharmacology; D001943:Breast Neoplasms / Q000188:drug therapy*; D045744:Cell Line, Tumor; D002470:Cell Survival; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008942:Mitoxantrone / Q000008:administration & dosage / Q000494:pharmacology*; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D017319:Photosensitizing Agents; D008942:Mitoxantrone