title: JAK's SOCS: a mechanism of inhibition.
abstract: SOCS1 and SOCS3 are specific inhibitors for JAK tyrosine kinases. In this issue of Immunity, Babon et al. (2012) discovered the inhibition mechanism of SOCS3 by employing nuclear magnetic resonance and classical enzyme kinetics.
authors.affiliation: Department of Microbiology and Immunology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. yoshimura@a6.keio.jp
authors.forename: Akihiko
authors.initials: A
authors.lastname: Yoshimura
authors.forename: Hideo
authors.initials: H
authors.lastname: Yasukawa