title: Changes caused by haloperidol are blocked by music in Wistar rat.
abstract: This study sought to evaluate the effect of classical music, using Mozart's sonata for two pianos (K. 448), on changes in dopamine (DA) levels in the striatal nucleus (SN), prefrontal cortex (PFC) and mesencephalon, and on prolactin (PRL) and corticosterone secretion in adult male Wistar rats. Rats were divided into four groups: (1) control, (2) haloperidol treatment (single dose of 2 mg/kg s.c.), (3) music (two 2-h sessions per day) and (4) haloperidol plus music. Rats were sacrificed 2 h after haloperidol injection. Music prompted a fall in plasma PRL and corticosterone levels in healthy rats (P < 0.05) and prevented the increase in levels triggered by haloperidol (P < 0.001). Moreover, exposure to music was associated with a significant increase in DA levels in all groups, with the increase being particularly marked in PFC and SN (P < 0.001). Haloperidol is a recognised D2 receptor antagonist, and these findings suggest that music, by contrast, enhances DA activity and turnover in the brain. The results obtained here bear out reports that music triggers a reduction in systolic pressure and an increase in mesencephalon dopamine levels in human and rats treated with ecstasy, through a calmodulin-dependent system.
authors.affiliation: Departamento de Bioquímica y Biología Molecular, Instituto Maimónides de Investigación Biomédica de Córdoba, Universidad de Córdoba, Avda. Menendez Pidal s/n, 14004, Córdoba, Spain. b72tacui@uco.es
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Tasset
authors.forename: Ismael
authors.initials: I
authors.lastname: Quero
authors.forename: Ángel D
authors.initials: ÁD
authors.lastname: García-Mayórgaz
authors.forename: Manuel Causse
authors.initials: MC
authors.lastname: del Río
authors.forename: Isaac
authors.initials: I
authors.lastname: Túnez
authors.forename: Pedro
authors.initials: P
authors.lastname: Montilla
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D003345:Corticosterone / Q000097:blood; D004298:Dopamine / Q000378:metabolism; D018492:Dopamine Antagonists / Q000494:pharmacology*; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D008636:Mesencephalon / Q000187:drug effects / Q000378:metabolism; D009146:Music; D017397:Prefrontal Cortex / Q000187:drug effects / Q000378:metabolism; D011388:Prolactin / Q000097:blood / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
chemical_list: D018492:Dopamine Antagonists; D011388:Prolactin; D006220:Haloperidol; D004298:Dopamine; D003345:Corticosterone