title: Local anaesthetics.
abstract: Although there are two types of LA, amides are now more commonly used. Understanding the pharmacology and physicochemical properties of LAs enables prediction of speed of onset, duration of action and determination of the correct LA for a particular clinical requirement. Drug concentration is expressed as a percentage such that 1% = 1 g/100 ml = 1,000 mg/100 ml = 10 mg/ml. Lipid rescue therapy has been shown to be a very effective treatment for LA toxicity.
authors.affiliation: Nottingham University Hospitals NHS Trust, City Hospital Campus, UK. james.french@nuh.nhs.uk
authors.forename: J
authors.initials: J
authors.lastname: French
authors.forename: L M
authors.initials: LM
authors.lastname: Sharp
mesh_terms: D000779:Anesthetics, Local / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D000075202:Contraindications; D004837:Epinephrine; D005947:Glucose / Q000494:pharmacology; D006801:Humans; D009407:Nerve Block / Q000379:methods; D019990:Perioperative Care / Q000379:methods*; D014677:Pharmaceutical Vehicles / Q000494:pharmacology; D014665:Vasodilator Agents
chemical_list: D000779:Anesthetics, Local; D014677:Pharmaceutical Vehicles; D014665:Vasodilator Agents; D005947:Glucose; D004837:Epinephrine