title: Clinical outcomes of lung metastasectomy in patients with colorectal cancer.
abstract: OBJECTIVE
  To investigate prognostic factors of survival following curative, non-palliative surgical removal of lung metastases secondary to colorectal cancer (CRC).
  
  
  METHODS
  Between 1999 and 2009, a radical metastasectomy with curative intent was performed on lung metastases in 21 patients with CRC (15 male and 6 female; mean age: 57.4 ± 11.8 years; age range: 29-74 years) who had already undergone primary tumour resection.
  
  
  RESULTS
  The mean number of lung metastases ranged from one to five. The mean overall survival was 71 ± 35 mo (median: 25 mo). After adjusting for potential confounders, multivariable Cox regression analyses predicted only the number of lung metastases (1 vs ≥ 2; hazard ratio: 7.60, 95% confidence interval: 1.18-17.2, P = 0.03) as an independent predictor of poor survival following lung resection for metastatic CRC.
  
  
  CONCLUSIONS
  Resection of lung metastases is a safe and effective treatment in selected CRC patients with single lung metastases.
authors.affiliation: Department of Medical Oncology, Uludag University Medical School, Bursa 16059, Turkey.
authors.forename: Omer Fatih
authors.initials: OF
authors.lastname: Olmez
authors.forename: Erdem
authors.initials: E
authors.lastname: Cubukcu
authors.forename: Ahmet Sami
authors.initials: AS
authors.lastname: Bayram
authors.forename: Unsal
authors.initials: U
authors.lastname: Akcali
authors.forename: Turkkan
authors.initials: T
authors.lastname: Evrensel
authors.forename: Cengiz
authors.initials: C
authors.lastname: Gebitekin
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000556:secondary* / Q000601:surgery*; D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000473:pathology* / Q000601:surgery; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary* / Q000601:surgery*; D008297:Male; D059146:Metastasectomy / Q000379:methods*; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome