title: A lamotrigine induced toxic epidermal necrolysis in a child.
abstract: Toxic epidermal necrolysis (TEN) is rare, life-threatening skin disorder that usually is caused by an adverse drug reaction. The exact pathogenesis of TEN is still unknown. Many treatments including prednisolone, cyclosporine and intravenous immunoglobulin (IVIG) can be used to halt the disease process. We present a 12-year-old girl with epilepsy who developed TEN after about 14 days of lamotrigine treatment. Lamotrigine was immediately discontinued. After receiving systemic corticosteroid treatment, the patient had a complete recovery. Antiepileptic-induced TEN can be mortal in some cases. Thus, we would like to point out the importance of early diagnosis and treatment.
authors.affiliation: Department of Dermatology, Yuzuncu Yil University Faculty of Medicine, Van, Turkey.
authors.forename: O
authors.initials: O
authors.lastname: Calka
authors.forename: A S
authors.initials: AS
authors.lastname: Karadag
authors.forename: S G
authors.initials: SG
authors.lastname: Bilgili
authors.forename: G
authors.initials: G
authors.lastname: Bulut
authors.forename: F
authors.initials: F
authors.lastname: Altun
authors.forename: A Z
authors.initials: AZ
authors.lastname: Burakgazi
mesh_terms: D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects*; D002648:Child; D004338:Drug Combinations; D004827:Epilepsy / Q000188:drug therapy; D005260:Female; D006801:Humans; D000077213:Lamotrigine; D000077287:Levetiracetam; D010889:Piracetam / Q000008:administration & dosage / Q000031:analogs & derivatives; D013262:Stevens-Johnson Syndrome / Q000209:etiology* / Q000473:pathology; D014227:Triazines / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D000927:Anticonvulsants; D004338:Drug Combinations; D014227:Triazines; D000077287:Levetiracetam; D000077213:Lamotrigine; D010889:Piracetam