title: Could age modify the effect of genetic variants in IL6 and TNF-α genes in multiple myeloma?
abstract: Cytokines play a central role in multiple myeloma (MM) pathogenesis thus genetic variations within cytokines coding genes could influence MM susceptibility and therapy outcome. We investigated the impact of 8 SNPs in these genes in 202 MM cases and 235 controls also evaluating their impact on therapy outcome in a subset of 91 patients. Despite the overall negative findings, we found a significant age-modified effect of IL6 and TNF-α SNPs, on MM risk and therapy outcome, respectively. Therefore, this observation suggests that genetic variation in inflammation-related genes could be an important mediator of the complex interplay between ageing and cancer.
authors.affiliation: Department of Biology, Genetics division, University of Pisa, Italy. a.martino@dkfz-heidelberg.de
authors.forename: Alessandro
authors.initials: A
authors.lastname: Martino
authors.forename: Gabriele
authors.initials: G
authors.lastname: Buda
authors.forename: Valentina
authors.initials: V
authors.lastname: Maggini
authors.forename: Francesco
authors.initials: F
authors.lastname: Lapi
authors.forename: Antonella
authors.initials: A
authors.lastname: Lupia
authors.forename: Domenica
authors.initials: D
authors.lastname: Di Bello
authors.forename: Enrico
authors.initials: E
authors.lastname: Orciuolo
authors.forename: Sara
authors.initials: S
authors.lastname: Galimberti
authors.forename: Roberto
authors.initials: R
authors.lastname: Barale
authors.forename: Mario
authors.initials: M
authors.lastname: Petrini
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Rossi
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D018572:Disease-Free Survival; D005260:Female; D014644:Genetic Variation; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy / Q000235:genetics* / Q000401:mortality; D020641:Polymorphism, Single Nucleotide; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: C508600:IL6 protein, human; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha