title: Postoperative nutritional effects of early enteral feeding compared with total parental nutrition in pancreaticoduodectomy patients: a prosepective, randomized study.
abstract: The benefits of early enteral feeding (EEN) have been demonstrated in gastrointestinal surgery. But, the impact of EEN has not been elucidated yet. We assessed the postoperative nutritional status of patients who had undergone pancreaticoduodenectomy (PD) according to the postoperative nutritional method and compared the clinical outcomes of two methods. A prospective randomized trial was undertaken following PD. Patients were randomly divided into two groups; the EEN group received the postoperative enteral feed and the control group received the postoperative total parenteral nutrition (TPN) management. Thirty-eight patients were included in our analyses. The first day of bowel movement and time to take a normal soft diet was significantly shorter in EEN group than in TPN group. Prealbumin and transferrin were significantly reduced on post-operative day (POD) 7 and were slowly recovered until POD 90 in the TPN group than in the EEN group. EEN group rapidly recovered weight after POD 21 whereas it was gradually decreased in TPN group until POD 90. EEN after PD is associated with preservation of weight compared with TPN and impact on recovery of digestive function after PD.
authors.affiliation: Department of Surgery, Gangnam Severance Hospital, Yonsei University Health System, Seoul, Korea.
authors.forename: Joon Seong
authors.initials: JS
authors.lastname: Park
authors.forename: Hye-Kyung
authors.initials: HK
authors.lastname: Chung
authors.forename: Ho Kyoung
authors.initials: HK
authors.lastname: Hwang
authors.forename: Jae Keun
authors.initials: JK
authors.lastname: Kim
authors.forename: Dong Sup
authors.initials: DS
authors.lastname: Yoon
mesh_terms: D000368:Aged; D021441:Carcinoma, Pancreatic Ductal / Q000503:physiopathology / Q000601:surgery / Q000628:therapy; D004064:Digestive System / Q000503:physiopathology; D004750:Enteral Nutrition / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D010190:Pancreatic Neoplasms / Q000503:physiopathology / Q000601:surgery / Q000628:therapy; D016577:Pancreaticoduodenectomy / Q000009:adverse effects; D010289:Parenteral Nutrition, Total; D011182:Postoperative Care / Q000379:methods*; D011184:Postoperative Period; D011446:Prospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D015430:Weight Gain; D015431:Weight Loss