title: Comparison of Gd-Bz-TTDA, Gd-EOB-DTPA, and Gd-BOPTA for dynamic MR imaging of the liver in rat models.
abstract: To evaluate the competitive potential of a new lipophilic paramagnetic complex, Gd-Bz-TTDA [4-benzyl-3,6,10-tri (carboxymethyl)-3,6,10-triazado-decanedioic acid] compared with two other commercially available MR hepatobiliary contrast agents, gadobenate dimeglumine (Gd-BOPTA) and gadoxetic acid (Gd-EOB-DTPA), dynamic MR imaging studies were performed on normal and hepatocellular carcinoma (HCC) rat models using a 1.5-Tesla MR scanner. The results indicate that normal rats that were injected with 0.1 mmol/kg Gd-Bz-TTDA showed significantly more intense and persistent liver enhancement than those that were injected with the same dose of Gd-EOB-DTPA or Gd-BOPTA. All of these agents showed similar enhancement patterns in the implanted HCC. The liver-lesion contrast-to-noise ratios were higher and more persistent in rats that were injected with Gd-Bz-TTDA. These results indicate that Gd-Bz-TTDA is comparable with the commercially available hepatobiliary agents, Gd-EOB-DTPA and Gd-BOPTA, and can result in more intense and prolonged liver enhancement while still providing better liver-lesion discrimination. These results warrant further large-scale studies.
authors.affiliation: Department of Medical Imaging, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. tsjaw@kmu.edu.tw
authors.forename: Twei-Shiun
authors.initials: TS
authors.lastname: Jaw
authors.forename: Shih-Hsien
authors.initials: SH
authors.lastname: Chen
authors.forename: Yun-Ming
authors.initials: YM
authors.lastname: Wang
authors.forename: Jui-Sheng
authors.initials: JS
authors.lastname: Hsu
authors.forename: Yu-Ting
authors.initials: YT
authors.lastname: Kuo
authors.forename: Yen-Yu
authors.initials: YY
authors.lastname: Chiu
authors.forename: Kun-Bow
authors.initials: KB
authors.lastname: Tsai
authors.forename: Tsyh-Jyi
authors.initials: TJ
authors.lastname: Hsieh
authors.forename: Gin-Chung
authors.initials: GC
authors.lastname: Liu
mesh_terms: D000818:Animals; D003287:Contrast Media; D019786:Gadolinium DTPA; D008099:Liver / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008536:Meglumine / Q000031:analogs & derivatives*; D009942:Organometallic Compounds; D051381:Rats; D017208:Rats, Wistar
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C496928:gadolinium 3,6,10-tri(carboxymethyl)-3,6,10-triazadodecanedioic acid; C073590:gadolinium ethoxybenzyl DTPA; C064572:gadobenic acid; D008536:Meglumine; D019786:Gadolinium DTPA