title: Expression of Cav-1 in tumour cells, rather than in stromal tissue,             may promote cervical squamous cell carcinoma proliferation, and correlates with             high-risk HPV infection.
abstract: Altered expression of caveolin-1 (Cav-1) is observed in various types of cancers. However, little research has been reported regarding the correlation between the expression of Cav-1 and cervical cancer. Here, we investigated the clinical significance of Cav-1 expression using quantum dot (QD)-based immunofluorescence staining in cervical cancer and its correlation with high-risk human papilloma virus (HPV) infection detected by chromogenic in situ hybridization. Our results showed that the positive rates of Cav-1 protein in normal cervical mucosa, CIN, cervical adenocarcinoma and SCC were: 0, 33, 19 and 55%, respectively. The differences in Cav-1 protein expression in cervical SCC compared to the other three groups were all statistically significant. Absence of stromal Cav-1 protein in 58 cases of cervical SCC was 67%. The positive rates of the Cav-1 protein in tumour and stromal cells of cervical SCC were not correlated with clinicopathological parameters. In the cervical SCC tissues, Cav-1 expression in tumour cells was not associated with stromal Cav-1 expression, but a positive correlation existed with the PCNA protein and high-risk of HPV infection. The results presented here suggest that expression of Cav-1 in the tumour cells, rather than in the stromal tissue surrounding the tumour, may promote cervical SCC cell proliferation, and correlates with high-risk HPV infection.
authors.affiliation: Department of Pathology, Maternal and Child Health Hospital of Hubei Province,Wuhan 430072, PR China.
authors.forename: Jun
authors.initials: J
authors.lastname: Sun
authors.forename: Jun
authors.initials: J
authors.lastname: Gao
authors.forename: Jun Bo
authors.initials: JB
authors.lastname: Hu
authors.forename: Li Fang
authors.initials: LF
authors.lastname: Fan
authors.forename: Xiao Bo
authors.initials: XB
authors.lastname: Zhu
authors.forename: Roz
authors.initials: R
authors.lastname: Subahan
authors.forename: Hong Lei
authors.initials: HL
authors.lastname: Chen
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology / Q000821:virology; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology* / Q000821:virology; D051242:Caveolin 1 / Q000378:metabolism*; D049109:Cell Proliferation; D002584:Cervix Uteri / Q000378:metabolism* / Q000473:pathology / Q000821:virology; D005260:Female; D006801:Humans; D009092:Mucous Membrane / Q000378:metabolism; D030361:Papillomavirus Infections / Q000150:complications / Q000378:metabolism* / Q000821:virology; D045663:Quantum Dots; D017154:Stromal Cells / Q000378:metabolism / Q000821:virology; D002583:Uterine Cervical Neoplasms / Q000378:metabolism* / Q000473:pathology* / Q000821:virology
chemical_list: C495540:CAV1 protein, human; D051242:Caveolin 1