title: Cervical cytological abnormalities and factors associated with high-grade squamous intraepithelial lesions among HIV-infected women from Rio de Janeiro, Brazil.
abstract: Although cervical cancer remains a major public health problem in Brazil, knowledge of cervical cytological abnormalities among HIV-infected women remains scarce. At baseline evaluation of a cohort followed in Rio de Janeiro, Brazil, 703 HIV-infected women underwent cytology-based cervical cancer screening and human papillomavirus (HPV) DNA testing. Poisson regression analysis was used to evaluate the association of factors with the presence of high-grade squamous intraepithelial lesions (HSIL). Cervical cytology was abnormal in 24.3% of the women; 4.1% had HSIL. Beyond HPV infection, factors independently associated with the presence of HSIL was age (≥25 and ≤40 years, prevalence ratio [PR] 2.60, 95% confidence interval [CI] 1.11-6.10), and more than three pregnancies was protective (PR 0.33, 95% CI 0.11-0.94). High coverage of cervical cancer screening is warranted to prevent morbidity and mortality from cervical cancer in this population.
authors.affiliation: Instituto de Pesquisa Clínica Evandro Chagas, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
authors.forename: P M
authors.initials: PM
authors.lastname: Luz
authors.forename: L
authors.initials: L
authors.lastname: Velasque
authors.forename: R K
authors.initials: RK
authors.lastname: Friedman
authors.forename: F
authors.initials: F
authors.lastname: Russomano
authors.forename: A C
authors.initials: AC
authors.lastname: Andrade
authors.forename: R I
authors.initials: RI
authors.lastname: Moreira
authors.forename: J
authors.initials: J
authors.lastname: Chicarino-Coelho
authors.forename: E
authors.initials: E
authors.lastname: Pires
authors.forename: V G
authors.initials: VG
authors.lastname: Veloso
authors.forename: B
authors.initials: B
authors.lastname: Grinsztejn
mesh_terms: D000328:Adult; D001938:Brazil / Q000453:epidemiology; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology* / Q000473:pathology / Q000821:virology; D002584:Cervix Uteri / Q000473:pathology*; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D015999:Multivariate Analysis; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000150:complications* / Q000453:epidemiology; D016012:Poisson Distribution; D015995:Prevalence; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000821:virology; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology* / Q000473:pathology / Q000821:virology