title: High nuclear poly-(ADP-ribose)-polymerase expression is prognostic of improved survival in pancreatic cancer.
abstract: OBJECTIVE
  Poly-(ADP-ribose)-polymerases (PARPs) act as post-translational modifiers of proteins that are mainly involved in the DNA repair machinery, and have recently been shown to be predictive of pathologically complete remission after chemotherapy in breast cancer. In the pancreas, PARP expression has so far only been studied in inflammatory conditions. Therefore, in this study, we investigated the relevance of PARP in pancreatic cancer.
  
  
  RESULTS
  Cytoplasmic and nuclear PARP expression was assessed by immunohistochemistry in a population-based cohort of 178 adenocarcinomas of the pancreas and correlated with clinicopathological parameters. We found that low-level nuclear expression of PARP is associated with a poor prognosis (median survival 9.6 versus 14.5 months, P = 0.004).
  
  
  CONCLUSIONS
  Our analysis shows that nuclear PARP is an independent prognostic marker with respect to standard clinicopathological parameters. These results suggest that PARP should be further explored as a predictive factor with respect to conventional chemotherapy and concepts of PARP inhibitor therapy in pancreatic cancer.
authors.affiliation: Institute of Pathology, Charité University Medicine Berlin, Germany. frederick.klauschen@charite.de
authors.forename: Frederick
authors.initials: F
authors.lastname: Klauschen
authors.forename: Moritz
authors.initials: M
authors.lastname: von Winterfeld
authors.forename: Albrecht
authors.initials: A
authors.lastname: Stenzinger
authors.forename: Bruno V
authors.initials: BV
authors.lastname: Sinn
authors.forename: Jan
authors.initials: J
authors.lastname: Budczies
authors.forename: Carsten
authors.initials: C
authors.lastname: Kamphues
authors.forename: Marcus
authors.initials: M
authors.lastname: Bahra
authors.forename: Daniel
authors.initials: D
authors.lastname: Wittschieber
authors.forename: Wilco
authors.initials: W
authors.lastname: Weichert
authors.forename: Jana
authors.initials: J
authors.lastname: Striefler
authors.forename: Hanno
authors.initials: H
authors.lastname: Riess
authors.forename: Manfred
authors.initials: M
authors.lastname: Dietel
authors.forename: Carsten
authors.initials: C
authors.lastname: Denkert
mesh_terms: D000230:Adenocarcinoma / Q000201:enzymology* / Q000401:mortality*; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D010190:Pancreatic Neoplasms / Q000201:enzymology* / Q000401:mortality*; D011065:Poly(ADP-ribose) Polymerases / Q000096:biosynthesis*; D011379:Prognosis; D046888:Tissue Array Analysis
chemical_list: D014408:Biomarkers, Tumor; D011065:Poly(ADP-ribose) Polymerases