title: Synthesis of simplified tedanolide analogues--connecting tedanolide to myriaporone and gephyronic acid.
abstract: Southern belles! Simplified analogues of tedanolide, a natural product with picomolar activity against a range of tumor cell lines, were synthesized and evaluated for potency in mammalian cancer cells. The truncated analogues were found to retain significant activity in vitro (23 μmol mL(-1) for the example shown) compared with the parent compound tedanolide (0.33 nmol mL(-1)), and represent potential leads for the development of novel anticancer agents.
authors.affiliation: Leibniz Universität Hannover, Institut für Organische Chemie, Hannover, Germany.
authors.forename: Nina
authors.initials: N
authors.lastname: Diaz
authors.forename: Arun
authors.initials: A
authors.lastname: Naini
authors.forename: Yazh
authors.initials: Y
authors.lastname: Muthukumar
authors.forename: Florenz
authors.initials: F
authors.lastname: Sasse
authors.forename: Markus
authors.initials: M
authors.lastname: Kalesse
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D004852:Epoxy Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D005229:Fatty Acids, Monounsaturated / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy
chemical_list: D000475:Alkenes; D000970:Antineoplastic Agents; D004852:Epoxy Compounds; D005229:Fatty Acids, Monounsaturated; D018942:Macrolides; C092168:gephyronic acid; C476087:myriaporone 1; C119775:tedanolide