title: Anti-aging effects of high molecular weight proteoglycan from salmon             nasal cartilage in hairless mice.
abstract: Proteoglycans comprise a family of complex macromolecules consisting of             a core protein with covalently attached glycosaminoglycan (GAG) chains. The skin             anti-aging effects of oral administration of proteoglycan fractions with different             molecular weights from salmon nasal cartilage were investigated in a hairless             mouse model of skin aging; aging was caused by repeated ultraviolet B (UVB) irradiation.             Three proteoglycan fractions of different molecular weights were prepared from             salmon nasal cartilage water extract by ion-exchange column chromatography and             gel filtration column chromatography. Physiological and histological analysis             of the skin indicated that oral administration of high molecular weight proteoglycan             inhibited UVB-induced skin aging, defined as increased erythema, increased transepidermal             water loss (TEWL), decreased hydration, and epidermal and dermal hypertrophies.             The serum and dorsal skin inflammatory cytokine levels indicated that high molecular             weight proteoglycan acts on gut immunity and improves skin by inhibiting surplus             inflammatory cytokines produced by UVB irradiation. These results suggest that             high molecular weight proteoglycan from salmon nasal cartilage is effective in             preventing skin aging.
authors.affiliation: Science of Bioresources, The United Graduate School of Agricultural                     Sciences, Iwate University, Morioka, Japan.
authors.forename: Masashi
authors.initials: M
authors.lastname: Goto
authors.forename: Shota
authors.initials: S
authors.lastname: Yamazaki
authors.forename: Yoji
authors.initials: Y
authors.lastname: Kato
authors.forename: Kazushi
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Yohtaro
authors.initials: Y
authors.lastname: Katagata
mesh_terms: D000818:Animals; D002356:Cartilage / Q000737:chemistry*; D016207:Cytokines / Q000032:analysis / Q000097:blood / Q000276:immunology; D008297:Male; D051379:Mice; D008812:Mice, Hairless; D011509:Proteoglycans / Q000302:isolation & purification* / Q000494:pharmacology*; D012474:Salmon / Q000033:anatomy & histology; D012867:Skin / Q000187:drug effects / Q000276:immunology / Q000528:radiation effects / Q000648:ultrastructure; D015595:Skin Aging / Q000187:drug effects* / Q000528:radiation effects; D014466:Ultraviolet Rays
chemical_list: D016207:Cytokines; D011509:Proteoglycans