title: Hypoglycaemia: a little known effect of Venlafaxine overdose.
abstract: We report the case of a 39-year-old woman who presented with serotonin syndrome and hypoglycaemia likely due to intoxication with a very high dose of venlafaxine. This case of venlafaxine-associated hypoglycaemia was treated first by glucose perfusion, but despite large doses, hypoglycaemia recurred. Blood glucose normalized after injection of octreotide, eliminating the need for hypertonic glucose. Octreotide has been shown to decrease glucose requirements and the number of hypoglycaemic episodes in patients with sulfonylurea-induced hypoglycaemia but, to our knowledge, its ability to resolve hypoglycaemic episodes due to massive venlafaxine overdose has not yet been described.
authors.affiliation: CHRU de Tours, Réanimation Médicale, 2 Boulevard Tonnellé, Tours Cedex 9, France. cathyfrancino@hotmail.com
authors.forename: Marie-Catherine
authors.initials: MC
authors.lastname: Francino
authors.forename: Marie
authors.initials: M
authors.lastname: Bretaudeau Deguigne
authors.forename: Julie
authors.initials: J
authors.lastname: Badin
authors.forename: Alain
authors.initials: A
authors.lastname: Turcant
authors.forename: Dominique
authors.initials: D
authors.lastname: Perrotin
mesh_terms: D000328:Adult; D000525:Alprazolam / Q000627:therapeutic use; D000700:Analgesics / Q000009:adverse effects*; D014151:Anti-Anxiety Agents / Q000627:therapeutic use; D003511:Cyclohexanols / Q000009:adverse effects* / Q000493:pharmacokinetics; D003863:Depression / Q000188:drug therapy; D062787:Drug Overdose; D004359:Drug Therapy, Combination; D005260:Female; D005765:Gastrointestinal Agents / Q000627:therapeutic use; D006207:Half-Life; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced*; D015282:Octreotide / Q000627:therapeutic use; D020230:Serotonin Syndrome / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects* / Q000493:pharmacokinetics; D016896:Treatment Outcome; D000069470:Venlafaxine Hydrochloride
chemical_list: D000525:Alprazolam; D000700:Analgesics; D014151:Anti-Anxiety Agents; D003511:Cyclohexanols; D005765:Gastrointestinal Agents; D015282:Octreotide; D017367:Selective Serotonin Reuptake Inhibitors; D000069470:Venlafaxine Hydrochloride