title: Multimodal imaging guided photothermal therapy using functionalized graphene nanosheets anchored with magnetic nanoparticles.
abstract: In this work, a nanoscale reduced graphene oxide-iron oxide nanoparticle (RGO-IONP) complex is noncovalently functionalized with polyethylene glycol (PEG), obtaining a RGO-IONP-PEG nanocomposite with excellent physiological stability, strong NIR optical absorbance, and superparamagnetic properties. Using this theranostic nanoprobe, in-vivo triple modal fluorescence, photoacoustic, and magnetic resonance imaging are carried out, uncovering high passive tumor targeting, which is further used for effective photothermal ablation of tumors in mice.
authors.affiliation: Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials Laboratory, Soochow University, Suzhou, Jiangsu, China.
authors.forename: Kai
authors.initials: K
authors.lastname: Yang
authors.forename: Lilei
authors.initials: L
authors.lastname: Hu
authors.forename: Xingxing
authors.initials: X
authors.lastname: Ma
authors.forename: Shuoqi
authors.initials: S
authors.lastname: Ye
authors.forename: Liang
authors.initials: L
authors.lastname: Cheng
authors.forename: Xiaoze
authors.initials: X
authors.lastname: Shi
authors.forename: Changhui
authors.initials: C
authors.lastname: Li
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Li
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Liu
mesh_terms: D000818:Animals; D005290:Ferric Compounds / Q000737:chemistry; D006108:Graphite / Q000737:chemistry*; D008279:Magnetic Resonance Imaging; D058185:Magnetite Nanoparticles / Q000737:chemistry* / Q000627:therapeutic use; D051379:Mice; D053761:Nanocomposites / Q000737:chemistry* / Q000627:therapeutic use; D009369:Neoplasms / Q000175:diagnosis / Q000628:therapy; D010084:Oxidation-Reduction; D010087:Oxides / Q000737:chemistry; D010789:Phototherapy; D011092:Polyethylene Glycols / Q000737:chemistry
chemical_list: D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; D010087:Oxides; C000499:ferric oxide; D011092:Polyethylene Glycols; D006108:Graphite