title: From preoperative to intraoperative detection of hyperfunctioning parathyroid glands using tetrofosmin (99mTc) in primary hyperparathyroidism.
abstract: The impact of preoperative scintigraphy on the management of patients with primary hyperparathyroidism has been largely documented for more than two decades. More recently, preoperative scintigraphy has also been used to select patients for intraoperative detection of hyperfunctioning parathyroid glands thanks to a gamma-probe. This procedure is now widely used, with MIBI as the main radiopharmaceutical for both preoperative scintigraphy and intraoperative detection. However MIBI was not available in Slovakia until very recently and tetrofosmin (TF), the alternative 99mTc labelled radiopharmaceutical for myocardial imaging has some advantages over MIBI and a close biological behaviour. Thus we have been using TF also for parathyroid preoperative scintigraphy and for intraoperative detection, a systematic indication which has never been reported by others. This article aims to demonstrate the feasibility and to present our protocol for TF parathyroid imaging and intraoperative detection, closely associating surgeons, nuclear medicine specialists, pathologists and also biologists as intraoperative assay of intact PTH is necessary. The results of literature are subsequently reported and discussed (Tab. 2, Fig. 4, Ref. 35). Full Text in free PDF www.bmj.sk.
authors.affiliation: University Hospital of Bratislava, Hospital Stare Mesto, Department of Nuclear Medicine, Bratislava, Slovakia. sona.balogova@kapor.sk
authors.forename: S
authors.initials: S
authors.lastname: Balogova
authors.forename: M
authors.initials: M
authors.lastname: Cambal
authors.forename: A
authors.initials: A
authors.lastname: Simkova
authors.forename: L
authors.initials: L
authors.lastname: Kekenak
authors.forename: A
authors.initials: A
authors.lastname: Stecova
authors.forename: P
authors.initials: P
authors.lastname: Gregor
authors.forename: S
authors.initials: S
authors.lastname: Kinova
authors.forename: P
authors.initials: P
authors.lastname: Labas
mesh_terms: D006801:Humans; D049950:Hyperparathyroidism, Primary / Q000000981:diagnostic imaging* / Q000601:surgery; D007432:Intraoperative Period; D019060:Minimally Invasive Surgical Procedures; D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D010280:Parathyroid Glands / Q000000981:diagnostic imaging*; D010282:Parathyroid Neoplasms / Q000000981:diagnostic imaging*; D016105:Parathyroidectomy; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi
chemical_list: D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C078700:technetium tc-99m tetrofosmin; D017256:Technetium Tc 99m Sestamibi