title: DNA-damage-induced differentiation in hematopoietic stem cells.
abstract: Aging of hematopoietic stem cells (HSCs) is accompanied by diminished functional potential. Wang et al. now provide evidence for an HSC-specific differentiation checkpoint mediated by the transcription factor BATF, which limits self-renewal of HSCs in response to the accumulation of DNA damage.
authors.affiliation: Department of Stem Cell and Regenerative Biology, Harvard University, Immune Disease Institute, Children's Hospital Boston, Boston, MA 02116, USA.
authors.forename: Pankaj K
authors.initials: PK
authors.lastname: Mandal
authors.forename: Derrick J
authors.initials: DJ
authors.lastname: Rossi
mesh_terms: D000818:Animals; D059447:Cell Cycle Checkpoints; D002454:Cell Differentiation; D016922:Cellular Senescence; D004249:DNA Damage; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000378:metabolism*; D006801:Humans