title: A rare Hb H disease due to the - -(SEA) and 16.6 kb α-thalassemia-2 deletions.
abstract: A large deletional α-thalassemia-2 (α-thal-2) allele was identified in a Thai woman with Hb H disease. The proband has α-thal-1 (SEA type) in conjunction with a 16.6 kb deletion affecting the α2-globin allele. The proband had severe anemia and required a blood transfusion during puerperium.
authors.affiliation: Blood Disease Diagnostic Center, Hematology Division, Department of Pathology, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: Suravee
authors.initials: S
authors.lastname: Sroymora
authors.forename: Sumalee
authors.initials: S
authors.lastname: Jindadamrongwech
authors.forename: Punnee
authors.initials: P
authors.lastname: Butthep
authors.forename: Suporn
authors.initials: S
authors.lastname: Chuncharunee
mesh_terms: D000328:Adult; D000483:Alleles; D000740:Anemia / Q000235:genetics; D001483:Base Sequence; D002648:Child; D005260:Female; D006447:Hemoglobin H / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data; D060885:Multiplex Polymerase Chain Reaction; D010375:Pedigree; D017384:Sequence Deletion; D013785:Thailand; D055542:alpha-Globins / Q000235:genetics*; D017085:alpha-Thalassemia / Q000235:genetics*
chemical_list: D055542:alpha-Globins; D006447:Hemoglobin H