title: [Keratin 8 expression in mouth mucosa hyperkeratosis and squamous cell carcinoma ].
abstract: The immunohistochemical study of proliferation and intermediate filament--keratin 8 expressions at oral hyperkeratosis and oral Squamous cell carcinoma (OSCC) has been carried out. It has been shown, that the specific character of keratin 8 expressions can be used in differential diagnosis between oral hyperkeratosis and OSCC. Different types of oral hyperkeratosis (without atypia, SIN1, SIN2 and SIN3) can be differentiated by Ki-67 and keratin 8. We have found the moderate positive correlation between proliferation and a keratin 8 expression in neoplastic epithelial cells.
authors.forename: I I
authors.initials: II
authors.lastname: Babichenko
authors.forename: A S
authors.initials: AS
authors.lastname: Grigor'ian
authors.forename: A A
authors.initials: AA
authors.lastname: Katushkina
mesh_terms: D014408:Biomarkers, Tumor / Q000096:biosynthesis* / Q000235:genetics; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D049109:Cell Proliferation; D003937:Diagnosis, Differential; D004847:Epithelial Cells / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D053533:Keratin-8 / Q000096:biosynthesis* / Q000235:genetics; D019394:Ki-67 Antigen / Q000096:biosynthesis; D007972:Leukoplakia, Oral / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000378:metabolism* / Q000473:pathology; D009062:Mouth Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor; C426203:KRT8 protein, human; D053533:Keratin-8; D019394:Ki-67 Antigen