title: Dietary agents in cancer prevention: an immunological perspective.
abstract: Skin cancer is the most common form of cancer diagnosed in the United States. Exposure to solar ultraviolet (UV) radiations is believed to be the primary cause for skin cancer. Excessive UV radiation can lead to genetic mutations and damage in the skin's cellular DNA that in turn can lead to skin cancer. Lately, chemoprevention by administering naturally occurring non-toxic dietary compounds has proven to be a potential strategy to prevent the occurrence of tumors. Attention has been drawn toward several natural dietary agents such as resveratrol, one of the major components found in grapes, red wines, berries and peanuts, proanthocyanidins from grape seeds, (-)-epigallocatechin-3-gallate from green tea, etc. However, the effect these dietary agents have on the immune system and the immunological mechanisms involved therein are still being explored. In this review, we shall focus on the role of key chemopreventive agents on various immune cells and discuss their potential as antitumor agents with an immunological perspective.
authors.affiliation: Department of Surgery, Medical University of South Carolina, Charleston, SC, USA.
authors.forename: Ya Ying
authors.initials: YY
authors.lastname: Zheng
authors.forename: Bharathi
authors.initials: B
authors.lastname: Viswanathan
authors.forename: Pravin
authors.initials: P
authors.lastname: Kesarwani
authors.forename: Shikhar
authors.initials: S
authors.lastname: Mehrotra
mesh_terms: D056704:Adaptive Immunity / Q000187:drug effects* / Q000528:radiation effects; D001688:Biological Products / Q000494:pharmacology*; D002277:Carcinoma / Q000209:etiology / Q000276:immunology / Q000517:prevention & control*; D002392:Catechin / Q000031:analogs & derivatives / Q000494:pharmacology; D004032:Diet; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects* / Q000528:radiation effects; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000528:radiation effects; D008545:Melanoma / Q000209:etiology / Q000276:immunology / Q000517:prevention & control*; D044945:Proanthocyanidins / Q000494:pharmacology; D000077185:Resveratrol; D012867:Skin / Q000187:drug effects / Q000276:immunology* / Q000528:radiation effects; D012878:Skin Neoplasms / Q000209:etiology / Q000276:immunology / Q000517:prevention & control*; D013267:Stilbenes / Q000494:pharmacology; D014466:Ultraviolet Rays / Q000009:adverse effects
chemical_list: D001688:Biological Products; D044945:Proanthocyanidins; D013267:Stilbenes; D002392:Catechin; C045651:epigallocatechin gallate; D000077185:Resveratrol