title: The emerging role of the TGFβ tumor suppressor pathway in pancreatic cancer.
abstract: Pancreatic adenocarcinoma is one of the most aggressive human cancers. It displays many different chromosomal abnormalities and mutations. To design new therapeutic strategies, it is important to identify the signaling pathways and gene networks within this apparent complexity that are predominantly altered. The TGFβ signaling pathway and associated transcription network emerges as a central actor of pancreatic oncogenesis. Its tumor suppressor function in this tissue can be affected by several alterations.
authors.affiliation: Centre de Recherche en Cancérologie de Marseille, Laboratoire d'Oncologie Moléculaire, UMR1068 Inserm, Institut Paoli-Calmettes, Marseille, France.
authors.forename: David J
authors.initials: DJ
authors.lastname: Birnbaum
authors.forename: Emilie
authors.initials: E
authors.lastname: Mamessier
authors.forename: Daniel
authors.initials: D
authors.lastname: Birnbaum
mesh_terms: D004268:DNA-Binding Proteins; D050993:GATA6 Transcription Factor / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism; D010190:Pancreatic Neoplasms / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000235:genetics / Q000378:metabolism*
chemical_list: C112476:ARID1A protein, human; D004268:DNA-Binding Proteins; D050993:GATA6 Transcription Factor; C494759:GATA6 protein, human; D009687:Nuclear Proteins; D014157:Transcription Factors; D016212:Transforming Growth Factor beta