title: Sex differences in adult cerebral venous sinus thrombosis: a 10-year experience.
abstract: BACKGROUND
  Sex differences in the risk factors, presentation and outcome of cerebral venous sinus thrombosis (CVST) are poorly defined, despite a discrepant prevalence between males and females. The proportion of patients on hormonal therapy who develop CVST varies widely. We describe the clinical features, risk factors and outcome by sex and by hormone-related risk factors among a large cohort of patients.
  
  
  METHODS
  We reviewed records of 108 consecutive patients with CVST at a tertiary hospital in Calgary between 1999 and 2009. Descriptive statistics were used for between group comparisons (men, women with hormone-related risk factors and women without hormone-related risk factors).
  
  
  RESULTS
  Females made up 62% of patients, half of whom were on systemic hormonal therapy. Men and women without hormonal risk factors were older at onset. Oral contraceptive use was the major risk factor in women (45%) while concurrent mastoiditis was the most common predisposing factor in men (27%). Complications were frequent and overall mortality was 6%. Persisting deficits at discharge were more common in men (54% vs. 35% and 32%, p=0.036). There was a trend for women with hormone-related risk factors to have less residual focal neurologic deficit than the other groups (5% vs. 15% and 17%, p=0.051).
  
  
  CONCLUSIONS
  There are differences between sexes in the presentation, risk factors and outcome of patients with CVST.
authors.affiliation: Department of Clinical Neuroscience, University of Calgary, Calgary, Alberta, Canada.
authors.forename: Claire
authors.initials: C
authors.lastname: Hinnell
authors.forename: Janel
authors.initials: J
authors.lastname: Nadeau
authors.forename: Vanessa
authors.initials: V
authors.lastname: Lam
authors.forename: Michael D
authors.initials: MD
authors.lastname: Hill
authors.forename: Shelagh B
authors.initials: SB
authors.lastname: Coutts
mesh_terms: D000367:Age Factors; D005260:Female; D006801:Humans; D007239:Infections / Q000453:epidemiology; D020767:Intracranial Thrombosis / Q000453:epidemiology*; D008137:Longitudinal Studies; D008297:Male; D009765:Obesity / Q000453:epidemiology; D012307:Risk Factors; D012727:Sex Characteristics; D012851:Sinus Thrombosis, Intracranial / Q000453:epidemiology*; D019851:Thrombophilia / Q000453:epidemiology