title: Myxoma virus M064 is a novel member of the poxvirus C7L superfamily of host range factors that controls the kinetics of myxomatosis in European rabbits.
abstract: The myxoma virus (MYXV) carries three tandem C7L-like host range genes (M062R, M063R, and M064R). However, despite the fact that the sequences of these three genes are similar, they possess very distinctive functions in vivo. The role of M064 in MYXV pathogenesis was investigated and compared to the roles of M062 and M063. We report that M064 is a virulence factor that contributes to MYXV pathogenesis but lacks the host range properties associated with M062 and M063.
authors.affiliation: Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, Florida, USA.
authors.forename: Jia
authors.initials: J
authors.lastname: Liu
authors.forename: Sonia
authors.initials: S
authors.lastname: Wennier
authors.forename: Nissin
authors.initials: N
authors.lastname: Moussatche
authors.forename: Mary
authors.initials: M
authors.lastname: Reinhard
authors.forename: Richard
authors.initials: R
authors.lastname: Condit
authors.forename: Grant
authors.initials: G
authors.lastname: McFadden
mesh_terms: D000818:Animals; D002460:Cell Line; D015967:Gene Expression Regulation, Viral; D055786:Gene Knockout Techniques; D023061:Gene Order; D007700:Kinetics; D009233:Myxoma virus / Q000235:genetics* / Q000472:pathogenicity*; D009234:Myxomatosis, Infectious / Q000401:mortality / Q000821:virology*; D011817:Rabbits; D014764:Viral Proteins / Q000235:genetics* / Q000378:metabolism; D056189:Viral Tropism / Q000235:genetics; D014774:Virulence; D019065:Virus Assembly / Q000235:genetics
chemical_list: D014764:Viral Proteins