title: Intrauterine transfusion for parvovirus B19 infection: long-term neurodevelopmental outcome.
abstract: OBJECTIVE
  To evaluate long-term neurodevelopmental outcome of children treated with intrauterine transfusions for fetal anemia because of parvovirus B19 infection.
  
  
  METHODS
  Children treated with intrauterine transfusions for fetal anemia because of parvovirus B19 infection underwent standardized age-appropriate neurodevelopmental testing. Main outcome was the incidence of neurodevelopmental impairment.
  
  
  RESULTS
  Twenty-eight children were evaluated at a median age of 5 years (range, 1.5-13 years). Neurodevelopmental impairment was diagnosed in 3 of 28 (11%) children, including 1 child with combined cerebral palsy and severe developmental delay and 2 children with isolated severe developmental delay.
  
  
  CONCLUSIONS
  Neurodevelopmental impairment in children treated with intrauterine transfusion for parvovirus B19 infection is increased compared with the general population. Large long-term follow-up studies are required to determine potential risk factors.
authors.affiliation: Department of Pediatrics, Juliana Children's Hospital, HAGA Hospital, The Hague, The Netherlands.
authors.forename: Eveline P
authors.initials: EP
authors.lastname: De Jong
authors.forename: Irene T
authors.initials: IT
authors.lastname: Lindenburg
authors.forename: Jeanine M
authors.initials: JM
authors.lastname: van Klink
authors.forename: Dick
authors.initials: D
authors.lastname: Oepkes
authors.forename: Inge L
authors.initials: IL
authors.lastname: van Kamp
authors.forename: Frans J
authors.initials: FJ
authors.lastname: Walther
authors.forename: Enrico
authors.initials: E
authors.lastname: Lopriore
mesh_terms: D000293:Adolescent; D000751:Anemia, Neonatal / Q000628:therapy* / Q000821:virology; D001805:Blood Transfusion, Intrauterine / Q000009:adverse effects*; D002490:Central Nervous System / Q000254:growth & development*; D002648:Child; D002657:Child Development; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000453:epidemiology* / Q000209:etiology; D016731:Erythema Infectiosum / Q000150:complications / Q000628:therapy*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000628:therapy*; D016896:Treatment Outcome