title: Interleukin-10-1082G/A polymorphism and acute liver graft rejection: a meta-analysis.
abstract: OBJECTIVE
  To investigate the association between interleukin (IL)-10-1082 (G/A) promoter polymorphism and acute rejection (AR) in liver transplant (LT) recipients.
  
  
  METHODS
  Two investigators independently searched the Medline, Embase, China National Knowledge Infrastructure, and Chinese Biomedicine Databases. Summary odds ratios (ORs) and 95% CIs for IL-10-1082 G/A polymorphism and AR were calculated in a ﬁxed- and a random-effects model as appropriate.
  
  
  RESULTS
  This meta-analysis included seven case-control studies, which comprised 652 cases of LT recipients in which 241 cases developed AR and 411 cases did not develop AR. Overall, the variant A allele was not associated with AR risk when compared with the wild-type G allele (OR = 0.94, 95% CI: 0.64-1.39). Moreover, similar results were observed when the AA genotype was compared with the AG/GG genotype (OR = 1.05, 95% CI: 0.55-2.02). When stratifying for ethnicity, no signiﬁcant association was observed among either Caucasians or Asians. Because only one study was performed in Asian patients, the result of subgroup analysis by ethnicity would not be reliable for Asians. Limiting the analysis to the studies with controls in the Hardy-Weinberg equilibrium, the results were persistent and robust. No publication bias was found in the present study.
  
  
  CONCLUSIONS
  This meta-analysis suggests that IL-10-1082 G/A polymorphism may be not associated with AR risk in LT recipients among Caucasians.
authors.affiliation: Department of Liver and Vascular Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Liu
authors.forename: Bo
authors.initials: B
authors.lastname: Li
authors.forename: Wen-Tao
authors.initials: WT
authors.lastname: Wang
authors.forename: Yong-Gang
authors.initials: YG
authors.lastname: Wei
authors.forename: Lv-Nan
authors.initials: LN
authors.lastname: Yan
authors.forename: Tian-Fu
authors.initials: TF
authors.lastname: Wen
authors.forename: Ming-Qing
authors.initials: MQ
authors.lastname: Xu
authors.forename: Jia-Yin
authors.initials: JY
authors.lastname: Yang
mesh_terms: D000328:Adult; D016208:Databases, Factual; D005006:Ethnicity / Q000235:genetics; D005260:Female; D006084:Graft Rejection / Q000235:genetics*; D006801:Humans; D016753:Interleukin-10 / Q000235:genetics*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics; D012307:Risk Factors; D055815:Young Adult
chemical_list: D016753:Interleukin-10