title: Association between HLA-A and -B polymorphisms and susceptibility to Henoch-Schönlein purpura in Han and Mongolian children from Inner Mongolia.
abstract: We examined a possible association between HLA-A and  -B polymorphisms and susceptibility to Henoch-Schönlein purpura (HSP) in Han  and Mongolian children in Inner Mongolia, through a case-control study. Two  hundred and sixty-eight unrelated children were enrolled, including 56  Mongolian and 50 Han children with HSP, 66 healthy Mongolian and 96 healthy Han  children as a control group. HLA-A and -B alleles were indentified by  PCR-sequence-specific oligonucleotide analysis and were further analyzed by  PCR-sequencing-based typing (SBT). Frequencies of HLA-A*11, HLA-B*15 in  Mongolian patients and HLA-A*26, HLA-B*35, HLA-B*52 in Han patients were higher  than those in the corresponding control group (P < 0.05), while frequencies  of HLA-B*07 and -B*40 in Mongolian HSP patients were lower than those in the  control group (P < 0.05). Further analysis using PCR-SBT showed that all  HLA-A*11 were HLA-A*1101, and most HLA-B*15 were HLA-B*1501 in Mongolian HSP  patients. All HLA-A*26 were HLA-A*2601 and HLA-B*35 were mostly HLA-B*3503 in  Han patients. There were more Han patients with severe manifestations than  Mongolian patients (P < 0.05). Frequencies of HLA-A*26, HLA-B*35 and HLA-B*52  in Han patients were higher than in Mongolian patients (P < 0.05). We  conclude that HLA-A*11(*1101) and -B*15(*1501) are associated with  susceptibility to HSP in Mongolian children and HLA-A*26(*2601),  HLA-B*35(*3503) and HLA-B*52 are associated with susceptibility to HSP in Han  children. HLA-B*07 and -B*40 may be protective genes in Mongolian children. The  different frequencies of HLA-A and -B in Mongolian and Han children may be  responsible for the different manifestations in these two ethnic groups.
authors.affiliation: Department of Pediatrics, Affiliated Hospital, Inner Mongolia Medical College, Hohhot, Inner Mongolia, China.
authors.forename: S M
authors.initials: SM
authors.lastname: Ren
authors.forename: G L
authors.initials: GL
authors.lastname: Yang
authors.forename: C Z
authors.initials: CZ
authors.lastname: Liu
authors.forename: C X
authors.initials: CX
authors.lastname: Zhang
authors.forename: Q H
authors.initials: QH
authors.lastname: Shou
authors.forename: S F
authors.initials: SF
authors.lastname: Yu
authors.forename: W C
authors.initials: WC
authors.lastname: Li
authors.forename: X L
authors.initials: XL
authors.lastname: Su
mesh_terms: D000293:Adolescent; D000483:Alleles; D002648:Child; D002675:Child, Preschool; D002681:China; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D015234:HLA-A Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics*; D006801:Humans; D011695:IgA Vasculitis / Q000235:genetics*; D008297:Male; D020411:Oligonucleotide Array Sequence Analysis; D020641:Polymorphism, Single Nucleotide
chemical_list: D015234:HLA-A Antigens; D015235:HLA-B Antigens