title: Extracellular nucleic acids in maternal circulation as potential biomarkers for placental insufficiency.
abstract: Since the placenta is being continuously remodeled during normal placental development, extracellular nucleic acids of both fetal and placental origin, packed into either trophoblast-derived apoptotic bodies or shedding syncytiotrophoblast microparticles, may be detected in maternal circulation during the course of normal gestation. Placental-insufficiency-related pregnancy complications have been shown to be associated with excessive placental trophoblast apoptosis and shedding of placenta debris. Recent advances in the field are reviewed with a focus on the diagnostic potential of particular molecular biomarkers and their eventual implementation in the currently used predictive and diagnostic algorithms for placental-insufficiency-related pregnancy complications.
authors.affiliation: Department of Molecular Biology and Cell Pathology, Third Faculty of Medicine, Charles University in Prague, Prague 10, Czech Republic. ilona.hromadnikova@lf3.cuni.cz
authors.forename: Ilona
authors.initials: I
authors.lastname: Hromadnikova
mesh_terms: D015415:Biomarkers / Q000097:blood; D004247:DNA / Q000097:blood*; D005110:Extracellular Space / Q000235:genetics*; D005260:Female; D006801:Humans; D009035:Mothers; D010927:Placental Insufficiency / Q000097:blood* / Q000175:diagnosis / Q000235:genetics / Q000473:pathology*; D011247:Pregnancy; D012313:RNA / Q000097:blood*
chemical_list: D015415:Biomarkers; D012313:RNA; D004247:DNA