title: Mood modulates auditory laterality of hemodynamic mismatch responses during dichotic listening.
abstract: Hemodynamic mismatch responses can be elicited by deviant stimuli in a sequence of standard stimuli even during cognitive demanding tasks. Emotional context is known to modulate lateralized processing. Right-hemispheric negative emotion processing may bias attention to the right and enhance processing of right-ear stimuli. The present study examined the influence of induced mood on lateralized pre-attentive auditory processing of dichotic stimuli using functional magnetic resonance imaging (fMRI). Faces expressing emotions (sad/happy/neutral) were presented in a blocked design while a dichotic oddball sequence with consonant-vowel (CV) syllables in an event-related design was simultaneously administered. Twenty healthy participants were instructed to feel the emotion perceived on the images and to ignore the syllables. Deviant sounds reliably activated bilateral auditory cortices and confirmed attention effects by modulation of visual activity. Sad mood induction activated visual, limbic and right prefrontal areas. A lateralization effect of emotion-attention interaction was reflected in a stronger response to right-ear deviants in the right auditory cortex during sad mood. This imbalance of resources may be a neurophysiological correlate of laterality in sad mood and depression. Conceivably, the compensatory right-hemispheric enhancement of resources elicits increased ipsilateral processing.
authors.affiliation: Department of Psychiatry, Psychotherapy and Psychosomatics, Medical School, RWTH Aachen University, Aachen, Germany. lisa.schock@rwth-aachen.de
authors.forename: Lisa
authors.initials: L
authors.lastname: Schock
authors.forename: Miriam
authors.initials: M
authors.lastname: Dyck
authors.forename: Liliana R
authors.initials: LR
authors.lastname: Demenescu
authors.forename: J Christopher
authors.initials: JC
authors.lastname: Edgar
authors.forename: Ingo
authors.initials: I
authors.lastname: Hertrich
authors.forename: Walter
authors.initials: W
authors.lastname: Sturm
authors.forename: Klaus
authors.initials: K
authors.lastname: Mathiak
mesh_terms: D000328:Adult; D000339:Affect; D001303:Auditory Cortex / Q000502:physiology; D001921:Brain / Q000502:physiology; D004007:Dichotic Listening Tests; D004569:Electroencephalography / Q000379:methods; D004644:Emotions; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D015225:Magnetoencephalography; D008297:Male