title: Evidence and consequences of the central role of the kidneys in the pathophysiology of sympathetic hyperactivity.
abstract: Chronic elevation of the sympathetic nervous system has been identified as a major contributor to the complex pathophysiology of hypertension, states of volume overload - such as heart failure - and progressive kidney disease. It is also a strong determinant for clinical outcome. This review focuses on the central role of the kidneys in the pathogenesis of sympathetic hyperactivity. As a consequence, renal denervation may be an attractive option to treat sympathetic hyperactivity. The review will also focus on first results and the still remaining questions of this new treatment option.
authors.affiliation: Department of Nephrology, University Medical Center Utrecht Utrecht, Netherlands.
authors.forename: Eva E
authors.initials: EE
authors.lastname: Vink
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Blankestijn