title: Diffusion-weighted magnetic resonance imaging of lung cancer at 3.0 T: a preliminary study on monitoring diffusion changes during chemoradiation therapy.
abstract: OBJECTIVE
  The purpose of the study was to prospectively monitor changes of apparent diffusion coefficient (ADC) in perichemoradiation for lung cancer.
  
  
  METHODS
  Fourteen patients with lung cancer who underwent chemoradiation therapy were included. Diffusion-weighted (DW) images were obtained prior to and during chemoradiation therapy, and ADCs were compared.
  
  
  RESULTS
  Seven patients had qualified DW images before and during chemoradiation. Six responders had significant increase in ADC value during the chemoradiation compared with the pretreatment value (P=.028), while one nonresponder had a slight decrease.
  
  
  CONCLUSIONS
  These preliminary results show the potential of DW imaging in monitoring early response to chemoradiation in patients with lung cancer.
authors.affiliation: Department of Diagnostic Radiology, Cancer Hospital and Institute, Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Chang
authors.forename: Ning
authors.initials: N
authors.lastname: Wu
authors.forename: Han
authors.initials: H
authors.lastname: Ouyang
authors.forename: Yao
authors.initials: Y
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D001707:Biopsy, Needle; D001999:Bronchoscopy / Q000379:methods; D059248:Chemoradiotherapy / Q000379:methods*; D038524:Diffusion Magnetic Resonance Imaging; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000401:mortality / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods*; D009361:Neoplasm Invasiveness / Q000473:pathology; D009367:Neoplasm Staging; D011446:Prospective Studies; D018570:Risk Assessment; D018709:Statistics, Nonparametric; D016019:Survival Analysis; D016896:Treatment Outcome