title: Targeting the cancer-stroma interaction: a potential approach for pancreatic cancer treatment.
abstract: Recent studies have demonstrated that the interaction between the cancer and the stroma, play a key role in the development of pancreatic cancer. The desmoplasia, which consists of fibroblasts, pancreatic stellate cells, lymphatic and vascular endothelial cells, immune cells, pathologic increased nerves, and the extracellular matrix (ECM), creates a complex tumor microenvironment that promotes pancreatic cancer development, invasion, metastasis, and resistance to chemotherapy. Thus, the potential approach for targeting the components of this desmoplastic reaction or the pancreatic tumor microenvironment might represent a novel therapeutic approach to advanced pancreatic carcinoma. Novel therapies that target on the pancreatic tumor microenvironment should become one of the more effective treatments for pancreatic cancer.
authors.affiliation: Department of Hepatobiliary Surgery, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
authors.forename: Xuqi
authors.initials: X
authors.lastname: Li
authors.forename: Qingyong
authors.initials: Q
authors.lastname: Ma
authors.forename: Qinhong
authors.initials: Q
authors.lastname: Xu
authors.forename: Wanxing
authors.initials: W
authors.lastname: Duan
authors.forename: Jianjun
authors.initials: J
authors.lastname: Lei
authors.forename: Erxi
authors.initials: E
authors.lastname: Wu
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002450:Cell Communication / Q000187:drug effects*; D006801:Humans; D058990:Molecular Targeted Therapy; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D010190:Pancreatic Neoplasms / Q000098:blood supply / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D017154:Stromal Cells / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D059016:Tumor Microenvironment / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D009363:Neoplasm Proteins