title: Alteration of some inflammatory biomarkers by dietary oxysterols in rats.
abstract: Oxysterols are structurally similar to cholesterol, but are characterized by one or more additional oxygen-containing functional groups. These compounds are implicated in inflammation given their ability to cause irreversible damage to vascular cells. The aim of this study was to study the alteration of some inflammatory biomarkers in Wistar rats in response to dietary oxysterols. Eighteen rats were randomly divided into three groups of six rats each. A standard diet supplemented with 1% (w/w) pure cholesterol (Chol group) or 1% (w/w) of an oxidized cholesterol mixture (COPs group) was fed for 8 weeks. Blood serum was separated; abdominal, pericardial, and epididymal adipose tissue was removed carefully. The COPs subjects exhibited significant increase in blood pressure and serum triacylgycerols as well as increased body fat index and pericardic, abdominal, and epididymal adipose tissue. These effects were accompanied by elevated circulating levels of plasma high-sensitivity C-reactive protein, tumor necrosis factor alpha, and resistin. We suggest that dietary oxysterols have an important pro-inflammatory effect.
authors.affiliation: Facultad de Bioanálisis, Universidad Veracruzana, Carmen Serdán s/n, Col. Flores Magón, Veracruz, Ver, 91700, Mexico.
authors.forename: Ida
authors.initials: I
authors.lastname: Soto-Rodríguez
authors.forename: Alfonso
authors.initials: A
authors.lastname: Alexander-Aguilera
authors.forename: Antonio
authors.initials: A
authors.lastname: Zamudio-Pérez
authors.forename: Mireya
authors.initials: M
authors.lastname: Camara-Contreras
authors.forename: Guillermo
authors.initials: G
authors.lastname: Hernandez-Diaz
authors.forename: Hugo S
authors.initials: HS
authors.lastname: Garcia
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D015415:Biomarkers / Q000032:analysis; D001794:Blood Pressure / Q000187:drug effects; D002097:C-Reactive Protein / Q000032:analysis; D002791:Cholesterol, Dietary / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000097:blood; D006888:Hydroxycholesterols / Q000008:administration & dosage*; D007249:Inflammation / Q000139:chemically induced*; D007653:Ketocholesterols / Q000008:administration & dosage*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D052243:Resistin / Q000097:blood; D014280:Triglycerides / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D015415:Biomarkers; D002791:Cholesterol, Dietary; D006888:Hydroxycholesterols; D007653:Ketocholesterols; D052243:Resistin; D014280:Triglycerides; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein