title: Biologicals and fetal cell therapy for wound and scar management.
abstract: Few biopharmaceutical preparations developed from biologicals are available for tissue regeneration and scar management. When developing biological treatments with cellular therapy, selection of cell types and establishment of consistent cell banks are crucial steps in whole-cell bioprocessing. Various cell types have been used in treatment of wounds to reduce scar to date including autolog and allogenic skin cells, platelets, placenta, and amniotic extracts. Experience with fetal cells show that they may provide an interesting cell choice due to facility of outscaling and known properties for wound healing without scar. Differential gene profiling has helped to point to potential indicators of repair which include cell adhesion, extracellular matrix, cytokines, growth factors, and development. Safety has been evidenced in Phase I and II clinical fetal cell use for burn and wound treatments with different cell delivery systems. We present herein that fetal cells present technical and therapeutic advantages compared to other cell types for effective cell-based therapy for wound and scar management.
authors.affiliation: Cellular Therapy Unit, Department of Musculoskeletal Medicine, University Hospital of Lausanne, CHUV/UNIL, PAV 03, 1011 Lausanne, Switzerland.
authors.forename: Nathalie
authors.initials: N
authors.lastname: Hirt-Burri
authors.forename: Albert-Adrien
authors.initials: AA
authors.lastname: Ramelet
authors.forename: Wassim
authors.initials: W
authors.lastname: Raffoul
authors.forename: Anthony
authors.initials: A
authors.lastname: de Buys Roessingh
authors.forename: Corinne
authors.initials: C
authors.lastname: Scaletta
authors.forename: Dominique
authors.initials: D
authors.lastname: Pioletti
authors.forename: Lee Ann
authors.initials: LA
authors.lastname: Applegate