title: Notch signaling: numb makes the difference.
abstract: During Drosophila sensory organ precursor cell development, Numb segregates asymmetrically and functions as a cell fate determinant. Recent work now demonstrates in vivo that Numb inactivates Notch by promoting its endocytosis.
authors.affiliation: Institute for Transfusion Medicine, University Hospital Essen, Virchowstr. 179, 45147 Essen, Germany. bernd.giebel@uk-essen.de
authors.forename: Bernd
authors.initials: B
authors.lastname: Giebel
authors.forename: Andreas
authors.initials: A
authors.lastname: Wodarz
mesh_terms: D000818:Animals; D030801:Animals, Genetically Modified; D048749:Cytokinesis; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism; D004331:Drosophila melanogaster / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D004705:Endocytosis; D007605:Juvenile Hormones / Q000235:genetics / Q000378:metabolism; D008840:Microfilament Proteins / Q000235:genetics / Q000378:metabolism; D011485:Protein Binding; D051880:Receptors, Notch / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D029721:Drosophila Proteins; D007605:Juvenile Hormones; D008840:Microfilament Proteins; C497759:N protein, Drosophila; D051880:Receptors, Notch; C060606:numb protein, Drosophila; C112833:spdo protein, Drosophila