title: Dendrimers in cancer therapeutics and diagnosis.
abstract: Dendrimers represent a class of monodispersed synthetic macromolecules with a well defined three-dimensional structure of nanometer dimension in which a series of layered branches regularly extend from a central core molecule. Due to their precise nanoscale sizes, well-defined branched structures, and various surface modifications, dendrimers have been extensively investigated in a wide range of applications in the biomedical field, particularly in the therapeutics and diagnosis of cancer. This article gives an overview of the recent advances of dendrimers and dendrimer-based hybrid nanoparticles for cancer therapeutics and diagnosis applications.
authors.affiliation: State Key Laboratory for Modification of Chemical Fibers and Polymer Materials, Donghua University, Shanghai 201620, People's Republic of China.
authors.forename: Rui
authors.initials: R
authors.lastname: Guo
authors.forename: Xiangyang
authors.initials: X
authors.lastname: Shi
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D003287:Contrast Media / Q000008:administration & dosage; D050091:Dendrimers / Q000008:administration & dosage; D003952:Diagnostic Imaging / Q000379:methods; D016503:Drug Delivery Systems; D006801:Humans; D049329:Nanostructures / Q000008:administration & dosage; D009369:Neoplasms / Q000175:diagnosis / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents; D003287:Contrast Media; D050091:Dendrimers