title: LRRK2 in Transcription and Translation Regulation: Relevance for Parkinson's Disease.
abstract: Parkinson's disease (PD) is the most common neurodegenerative movement disorder and is characterized by the selective loss of dopaminergic neurons and the presence of Lewy bodies. Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most frequent cause of both familial and sporadic PD. One critical question is how PD-associated LRRK2 mutations cause neurodegeneration. Here, we discuss recent findings related to LRRK2-mediated regulation of gene expression and translation and provide a critical assessment of the current models that are used to address the impact of LRRK2 on the transcriptome. A better understanding of these mechanisms could provide important new clues into the function of LRRK2 during both normal and pathological conditions.
authors.affiliation: Centre de Recherche du CHUQ, Axe Neurosciences, Université Laval Québec, QC, Canada.
authors.forename: Véronique
authors.initials: V
authors.lastname: Dorval
authors.forename: Sébastien S
authors.initials: SS
authors.lastname: Hébert