title: Genomics: is it ready for primetime?
abstract: The next decade will focus on identifying the missing heritability of coronary artery disease (CAD). This process will involve a more comprehensive interrogation of common single nucleotide polymorphisms (SNPs) that impart modest biologic effect and an interrogation of rare SNPs that impart profound biologic effect. In parallel, an investigation of the underlying biology of the described association will likely yield novel pathways that provide therapeutic targets. Once we obtain a more complete inventory of sequence variation that predisposes to CAD, a more realistic assessment of the role of genetic risk scoring allied with standard risk algorithms will be possible.
authors.affiliation: Faculty of Medicine, McGill University, McIntyre Medical Building, 3655 promenade Sir William Osler Montreal, Quebec H3G 1Y6, Canada.
authors.forename: Sonny
authors.initials: S
authors.lastname: Dandona
authors.forename: Alexandre F R
authors.initials: AF
authors.lastname: Stewart
authors.forename: Robert
authors.initials: R
authors.lastname: Roberts
mesh_terms: D015415:Biomarkers; D019295:Computational Biology / Q000379:methods / Q000639:trends; D003324:Coronary Artery Disease / Q000453:epidemiology / Q000235:genetics; D005544:Forecasting; D020022:Genetic Predisposition to Disease; D023281:Genomics / Q000379:methods / Q000639:trends; D016045:Human Genome Project; D006801:Humans; D040582:Inheritance Patterns; D010597:Pharmacogenetics / Q000379:methods / Q000639:trends; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D015415:Biomarkers