title: Generation of leaf shape through early patterns of growth and tissue polarity.
abstract: A major challenge in biology is to understand how buds comprising a few cells can give rise to complex plant and animal appendages like leaves or limbs. We address this problem through a combination of time-lapse imaging, clonal analysis, and computational modeling. We arrive at a model that shows how leaf shape can arise through feedback between early patterns of oriented growth and tissue deformation. Experimental tests through partial leaf ablation support this model and allow reevaluation of previous experimental studies. Our model allows a range of observed leaf shapes to be generated and predicts observed clone patterns in different species. Thus, our experimentally validated model may underlie the development and evolution of diverse organ shapes.
authors.affiliation: John Innes Centre, Norwich Research Park, Norwich, UK.
authors.forename: Erika E
authors.initials: EE
authors.lastname: Kuchen
authors.forename: Samantha
authors.initials: S
authors.lastname: Fox
authors.forename: Pierre Barbier
authors.initials: PB
authors.lastname: de Reuille
authors.forename: Richard
authors.initials: R
authors.lastname: Kennaway
authors.forename: Sandra
authors.initials: S
authors.lastname: Bensmihen
authors.forename: Jerome
authors.initials: J
authors.lastname: Avondo
authors.forename: Grant M
authors.initials: GM
authors.lastname: Calder
authors.forename: Paul
authors.initials: P
authors.lastname: Southam
authors.forename: Sarah
authors.initials: S
authors.lastname: Robinson
authors.forename: Andrew
authors.initials: A
authors.lastname: Bangham
authors.forename: Enrico
authors.initials: E
authors.lastname: Coen
mesh_terms: D032161:Antirrhinum / Q000033:anatomy & histology / Q000235:genetics / Q000254:growth & development; D017360:Arabidopsis / Q000033:anatomy & histology / Q000235:genetics / Q000254:growth & development; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism; D016764:Cell Polarity; D003198:Computer Simulation; D017343:Genes, Plant; D008954:Models, Biological; D009024:Morphogenesis; D018515:Plant Leaves / Q000033:anatomy & histology* / Q000166:cytology / Q000254:growth & development*; D059008:Time-Lapse Imaging
chemical_list: D029681:Arabidopsis Proteins