title: ETS transcription factors and prostate cancer: the role of the family prototype ETS-1 (review).
abstract: The ETS family of transcription factors is known to play important roles in various biological processes such as development, differentiation, proliferation, apoptosis, migration, tissue remodeling, invasion and angiogenesis in various cell types including B cells, endothelial cells, fibroblasts as well as diverse neoplastic cells. In prostate cancer, recurrent gene fusions involving members of the ETS family are frequently reported. ETS-1, the prototype of the ETS family, is expressed in different cell types and is known to play various roles during both physiological and pathological conditions. In this review, we focus on studies investigating the role of ETS-1 in prostate cancer.
authors.affiliation: Institute of Pathology, University Hospital Bonn, D-53127 Bonn,                     Germany.
authors.forename: David
authors.initials: D
authors.lastname: Adler
authors.forename: Nicolas
authors.initials: N
authors.lastname: Wernert
mesh_terms: D000818:Animals; D002465:Cell Movement; D015870:Gene Expression; D006801:Humans; D008297:Male; D015514:Oncogene Proteins, Fusion / Q000235:genetics / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D050784:Proto-Oncogene Protein c-ets-1 / Q000235:genetics / Q000378:metabolism*; D012697:Serine Endopeptidases / Q000235:genetics / Q000378:metabolism; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism; D000071230:Transcriptional Regulator ERG
chemical_list: C072312:ERG protein, human; C494041:ETS1 protein, human; D015514:Oncogene Proteins, Fusion; D050784:Proto-Oncogene Protein c-ets-1; D015534:Trans-Activators; D000071230:Transcriptional Regulator ERG; D012697:Serine Endopeptidases; C421305:TMPRSS2 protein, human