title: Acyl carrier protein structural classification and normal mode analysis.
abstract: All acyl carrier protein primary and tertiary structures were gathered into the ThYme database. They are classified into 16 families by amino acid sequence similarity, with members of the different families having sequences with statistically highly significant differences. These classifications are supported by tertiary structure superposition analysis. Tertiary structures from a number of families are very similar, suggesting that these families may come from a single distant ancestor. Normal vibrational mode analysis was conducted on experimentally determined freestanding structures, showing greater fluctuations at chain termini and loops than in most helices. Their modes overlap more so within families than between different families. The tertiary structures of three acyl carrier protein families that lacked any known structures were predicted as well.
authors.affiliation: Department of Chemical and Biological Engineering, Iowa State University, Ames, Iowa 50011, USA.
authors.forename: David C
authors.initials: DC
authors.lastname: Cantu
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Forrester
authors.forename: Katherine
authors.initials: K
authors.lastname: Charov
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Reilly
mesh_terms: D000213:Acyl Carrier Protein / Q000737:chemistry* / Q000145:classification*; D000595:Amino Acid Sequence; D000818:Animals; D030161:Avian Proteins / Q000737:chemistry; D001426:Bacterial Proteins / Q000737:chemistry; D002645:Chickens; D005656:Fungal Proteins / Q000737:chemistry; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010802:Phylogeny; D017434:Protein Structure, Tertiary; D016415:Sequence Alignment
chemical_list: D000213:Acyl Carrier Protein; D030161:Avian Proteins; D001426:Bacterial Proteins; D005656:Fungal Proteins