title: Fetal transient clitoromegaly and transient hypertrophy of the labia minora in early and mid pregnancy.
abstract: OBJECTIVE
  The purpose of this study was to describe a series of cases of transient changes in the female fetal external genitalia.
  
  
  METHODS
  In our practice area, most pregnant women usually undergo a detailed sonographic survey of all fetal organs, including the external genitalia in early and mid pregnancy.
  
  
  RESULTS
  During the study period (1987-2010), 62,145 consecutive pregnant women were scanned. We detected 4 fetuses with an isolated finding of clitoromegaly at 15 to 16 weeks' gestation, which disappeared at 22 to 26 weeks. Maternal hormonal study results were normal. There was 1 case of clitoromegaly and a cloacal anomaly at 15 weeks' gestation, in which the clitoris retuned to a normal size at 22 weeks. In addition, there were 3 cases of hypertrophy of the labia minora in early pregnancy, which disappeared at 26 to 32 weeks. All fetuses in these series had a normal XX karyotype and normal external genitalia at birth.
  
  
  CONCLUSIONS
  Transient changes in the appearance of the fetal external genitalia may occur in chromosomally normal female fetuses.
authors.affiliation: Departments of Obstetrics and Gynecology, Rambam Medical Center and Faculty of Medicine, Technion–Israel, Institute of Technology, Haifa, Israel.
authors.forename: Etan Z
authors.initials: EZ
authors.lastname: Zimmer
authors.forename: Shraga
authors.initials: S
authors.lastname: Blazer
authors.forename: Zeev
authors.initials: Z
authors.lastname: Blumenfeld
authors.forename: Moshe
authors.initials: M
authors.lastname: Bronshtein
mesh_terms: D002987:Clitoris / Q000002:abnormalities / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D059785:Karyotype; D011247:Pregnancy; D011256:Pregnancy Outcome; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D016216:Ultrasonography, Prenatal; D014844:Vulva / Q000002:abnormalities* / Q000000981:diagnostic imaging*