title: Serum C-reactive protein levels predict neurological outcome after aneurysmal subarachnoid hemorrhage.
abstract: OBJECTIVE
  Our aim was to evaluate the relationship between serum C-reactive protein (CRP) levels and the neurological prognosis and development of vasospasm in patients with aneurysmal subarachnoid hemorrhage (aSAH).
  
  
  METHODS
  Eighty-two adult patients with aSAH diagnoses were prospectively evaluated. Glasgow Coma Scale (GCS) score, Hunt and Hess grade, Fisher grade, cranial CT scans, digital subtraction angiography studies and daily neurological examinations were recorded. Serial serum CRP measurements were obtained daily between admission and the tenth day. Glasgow Outcome Scale (GOS) and the modified Rankin Scale (mRS) were used to assess the prognosis.
  
  
  RESULTS
  Serum CRP levels were related to severity of aSAH. Patients with lower GCS scores and higher Hunt and Hess and Fisher grades presented statistically significant higher serum CRP levels. Patients with higher serum CRP levels had a less favorable prognosis.
  
  
  CONCLUSIONS
  Increased serum CRP levels were strongly associated with worse clinical prognosis in this study.
authors.affiliation: University of São Paulo, São Paulo SP, Brazil. frromero@ig.com.br
authors.forename: Flávio Ramalho
authors.initials: FR
authors.lastname: Romero
authors.forename: Eduardo de Freitas
authors.initials: Ede F
authors.lastname: Bertolini
authors.forename: Eberval G
authors.initials: EG
authors.lastname: Figueiredo
authors.forename: Manoel Jacobsen
authors.initials: MJ
authors.lastname: Teixeira
mesh_terms: D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D015331:Cohort Studies; D015600:Glasgow Coma Scale; D006801:Humans; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D012720:Severity of Illness Index; D013345:Subarachnoid Hemorrhage / Q000097:blood* / Q000150:complications; D020301:Vasospasm, Intracranial / Q000097:blood* / Q000209:etiology
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein