title: Default mode network abnormalities in idiopathic generalized epilepsy.
abstract: Idiopathic generalized epilepsy (IGE) is associated with widespread cortical network abnormalities on electroencephalography. Resting state functional connectivity (RSFC), based on fMRI, can assess the brain's global functional organization and its disruption in clinical conditions. We compared RSFC associated with the 'default mode network' (DMN) between people with IGE and healthy controls. Strength of functional connectivity within the DMN associated with seeds in the posterior cingulate cortex (PCC) and medial prefrontal cortices (MPFC) was compared between people with IGE and healthy controls and was correlated with seizure duration, age of seizure onset and age at scan. Those with IGE showed markedly reduced functional network connectivity between anterior and posterior cortical seed regions. Seizure duration positively correlates with RSFC between parahippocampal gyri and the PCC but negatively correlates with connectivity between the PCC and frontal lobe. The observed pattern of disruption provides evidence for integration- and segregation-type network abnormalities and supports aberrant network organization among people with IGE.
authors.affiliation: NYU Comprehensive Epilepsy Center, New York University School of Medicine, New York, NY, USA.
authors.forename: Megan L
authors.initials: ML
authors.lastname: McGill
authors.forename: Orrin
authors.initials: O
authors.lastname: Devinsky
authors.forename: Clare
authors.initials: C
authors.lastname: Kelly
authors.forename: Michael
authors.initials: M
authors.lastname: Milham
authors.forename: F Xavier
authors.initials: FX
authors.lastname: Castellanos
authors.forename: Brian T
authors.initials: BT
authors.lastname: Quinn
authors.forename: Jonathan
authors.initials: J
authors.lastname: DuBois
authors.forename: Jonathan R
authors.initials: JR
authors.lastname: Young
authors.forename: Chad
authors.initials: C
authors.lastname: Carlson
authors.forename: Jacqueline
authors.initials: J
authors.lastname: French
authors.forename: Ruben
authors.initials: R
authors.lastname: Kuzniecky
authors.forename: Eric
authors.initials: E
authors.lastname: Halgren
authors.forename: Thomas
authors.initials: T
authors.lastname: Thesen
mesh_terms: D000328:Adult; D001931:Brain Mapping; D016022:Case-Control Studies; D002540:Cerebral Cortex / Q000098:blood supply / Q000473:pathology*; D004569:Electroencephalography; D004829:Epilepsy, Generalized / Q000473:pathology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000098:blood supply / Q000473:pathology*; D010100:Oxygen / Q000097:blood; D055815:Young Adult
chemical_list: D010100:Oxygen