title: Chemiluminescence determination of gemifloxacin based on diperiodatoargentate (III)-sulphuric acid reaction in a micellar medium.
abstract: A novel flow-injection chemiluminescence (FI-CL) analysis method for the determination of gemifloxacin in the presence of cetyltrimethylammonium bromide (CTAB) surfactant micelles is described. Strong CL signal was generated during the reaction of gemifloxacin with diperiodatoargentate (III) in a sulfuric acid medium sensitized by CTAB. Under optimum experimental conditions, the CL intensity was linearly related to the concentration of gemifloxacin from 1.0 × 10(-9) to 3.0 × 10(-7) g/mL and the detection limit was 7.3 × 10(-10) g/mL (3σ). The relative standard deviation (RSD) was 1.7 % for a 3.0 × 10(-8) g/mL gemifloxacin solution (11 repeated measurements). The proposed method was successfully applied to the determination of gemifloxacin in pharmaceutical preparations and biological fluids. The possible mechanism of the CL reaction is also discussed briefly.
authors.affiliation: School of Chemistry and Chemical Engineering, Shihezi University, and Xinjiang Bingtuan Key Laboratory for Green Processing of Chemical Engineering, Shihezi, Xinjiang, China. nnllzzff@163.com
authors.forename: Fang
authors.initials: F
authors.lastname: Zhao
authors.forename: Wen-hui
authors.initials: WH
authors.lastname: Zhao
authors.forename: Wei
authors.initials: W
authors.lastname: Xiong
mesh_terms: D000900:Anti-Bacterial Agents / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D056831:Coordination Complexes / Q000737:chemistry*; D004355:Drug Stability; D017022:Flow Injection Analysis / Q000295:instrumentation / Q000379:methods*; D024841:Fluoroquinolones / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D000077735:Gemifloxacin; D006801:Humans; D008163:Luminescent Measurements / Q000295:instrumentation / Q000379:methods*; D008823:Micelles; D009287:Naphthyridines / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D013464:Sulfuric Acids / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D056831:Coordination Complexes; D024841:Fluoroquinolones; D008823:Micelles; D009287:Naphthyridines; D013464:Sulfuric Acids; C549491:diperiodatoargentate(III); C033158:sulfuric acid; D000077735:Gemifloxacin