title: Biotransformation of sophoricoside in Fructus sophorae by the fungus Schizophyllum commune.
abstract: Biotransformation of sophoricoside in Fructus sophorae was performed with Schizophyllum commune. Sophoricoside was firstly metabolized to 4',5,7-trihydroxyisoflavone (2), and then to 4',7-dihydroxy-5-methoxyisoflavone (3) and 5,7-dihydroxy-4'-methoxyisoflavone (4) as determined by NMR and MS analyzes. The content of compound (2) was increased by more than 30-fold, and compound (3) is a new product that showed good cytotoxic activity with an IC(50) of 12.1 nmol/ml against MCF-7 cells.
authors.affiliation: Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China.
authors.forename: Jianguo
authors.initials: J
authors.lastname: Wu
authors.forename: Xialu
authors.initials: X
authors.lastname: Yang
authors.forename: Juan
authors.initials: J
authors.lastname: Ge
authors.forename: Yiping
authors.initials: Y
authors.lastname: Zhang
authors.forename: Lin
authors.initials: L
authors.lastname: Wu
authors.forename: Jianmiao
authors.initials: J
authors.lastname: Liu
authors.forename: Xiaoyu
authors.initials: X
authors.lastname: Zhang
mesh_terms: D001578:Benzopyrans / Q000493:pharmacokinetics*; D001711:Biotransformation; D005638:Fruit / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D012567:Schizophyllum / Q000378:metabolism*; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D001578:Benzopyrans; C120642:sophoricoside