title: Peripheral chemokine levels in women with recurrent major depression with suicidal ideation.
abstract: OBJECTIVE
  To compare serum levels of MCP-1/CCL2, RANTES/CCL5, and Eotaxin/CCL11 between female patients with recurrent major depressive disorder (MDD) and healthy controls, verifying if there is a difference in the levels of these mediators between those with or without current suicidal ideation.
  
  
  METHODS
  Thirty female outpatients with recurrent MDD were divided in two groups accordingly the presence or absence of suicidal ideation. These groups were compared with 16 healthy controls. Serum levels of MCP-1/CCL2, RANTES/CCL5, and Eotaxin/CCL11 were determined. Depression severity was evaluated by Beck Depression Inventory (BDI). Suicidal ideation was assessed by SCID-I and BDI.
  
  
  RESULTS
  Patients with recurrent MDD and healthy controls did not differ in age, socioeconomic status, and education. All patients reported high scores of BDI (mean, SD, n; 29.75, 10.55, 28). Multivariable analysis of covariance adjusted for age and BMI showed that MDD patients with suicidal ideation presented lower levels of MCP-1/ CCL2 and RANTES/CCL5 (p < 0.001) and higher levels of Eotaxin/CCL11 (p = 0.04) compared to healthy controls. These differences remained significant after adjusting for depression severity.
  
  
  CONCLUSIONS
  The findings of this study indicated that the presence of recurrent MDD with suicidal ideation is associated with differences in inflammatory chemokines when compared to those without suicidal ideation.
authors.affiliation: Developmental Cognitive Neuroscience Research Group, Post-Graduate Program in Psychology, Pontifícia Universidade Católica, Porto Alegre, Brazil. rodrigo.grassi@pucrs.br
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Grassi-Oliveira
authors.forename: Elisa
authors.initials: E
authors.lastname: Brieztke
authors.forename: Antônio
authors.initials: A
authors.lastname: Teixeira
authors.forename: Júlio Carlos
authors.initials: JC
authors.lastname: Pezzi
authors.forename: Márcio
authors.initials: M
authors.lastname: Zanini
authors.forename: Rodrigo Pestana
authors.initials: RP
authors.lastname: Lopes
authors.forename: Moisés Evandro
authors.initials: ME
authors.lastname: Bauer
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D018925:Chemokines / Q000097:blood*; D003865:Major Depressive Disorder / Q000097:blood* / Q000523:psychology; D005260:Female; D006801:Humans; D059020:Suicidal Ideation
chemical_list: D015415:Biomarkers; D018925:Chemokines