title: [Effects of Tiangou Jiangya capsule on hypertension and hemodynamics in anaesthetized dogs].
abstract: OBJECTIVE
  To evaluate the effects of Tiangou Jiangya capsule on blood pressure and hemodynamics in anesthetized Beagle dogs.
  
  
  METHODS
  Anesthetized dogs were divided into five groups: Tiangou Jiangya capsule 3-dose groups as 1.6, 3.2, 6.4 g x kg(-1), positive control group was giving captopril, negative control was giving 0.5% CMC-Na, duodenal administration. The blood pressure and hemodynamic changes were observed.
  
  
  RESULTS
  The systolic blood pressure of middle-dose Tiangou Jiangya capsule group was significantly reduced at 30 min after administration. The systolic blood pressure (SAP) and diastolic blood pressure (DAP) of high-dose group of Tiangou Jiangya capsule was significantly reduced at 15 min to 90 min after administration. High-dose Tiangou Jiangya capsule can also significantly reduce cardiac work (LVW) and total peripheral resistance (TPR). Tiangou Jiangya capsule had no significant effect on the other hemodynamic parameters and myocardial oxygen consumption.
  
  
  CONCLUSIONS
  Tiangou Jiangya capsule has a significant effect on reducing blood pressure, which is related to the reducing total peripheral resistance and reducing cardiac work. The result can provide a reference to further clarify the Tiangou Jiangya capsule mechanism on reducing blood pressure.
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine Sciences, Beijing 100700, China.
authors.forename: Yujie
authors.initials: Y
authors.lastname: Li
authors.forename: Qing
authors.initials: Q
authors.lastname: Yang
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Weng
authors.forename: Ying
authors.initials: Y
authors.lastname: Chen
authors.forename: Shuyuan
authors.initials: S
authors.lastname: Zhou
authors.forename: Dan
authors.initials: D
authors.lastname: Li
authors.forename: Xiaoxin
authors.initials: X
authors.lastname: Zhu
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D001592:Benzyl Alcohols / Q000494:pharmacology / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D004195:Disease Models, Animal; D004285:Dogs; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D005419:Flavonoids / Q000494:pharmacology / Q000627:therapeutic use*; D005663:Furans / Q000494:pharmacology / Q000627:therapeutic use*; D005960:Glucosides / Q000494:pharmacology / Q000627:therapeutic use*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006973:Hypertension / Q000188:drug therapy*; D017705:Lignans / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D000959:Antihypertensive Agents; D001592:Benzyl Alcohols; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D005663:Furans; D005960:Glucosides; D017705:Lignans; C560376:Tiangou