title: [Effects of Tiangou Jiangya capsule on blood pressure in spontaneous hypertensive rat].
abstract: OBJECTIVE
  To investigate the effects of Tiangou Jiangya capsule on blood pressure of spontaneous hypertensive rats.
  
  
  METHODS
  The 13-14 week SPF rats were selected and randomly divided into model groups, the low, middle, high dose of Tiangou Jiangya capsule groups, positive control group administrated with captopril. Drugs were intragastric administrated once per day, lasting four weeks. The blood pressure, heart rate, heart ventricle indexes, urinary volume and the level of PRA,angiotensing II (Ang II), aldosterone (ALD) of rats were observed.
  
  
  RESULTS
  The low, middle, high dose of Tiangou Jiangya capsule can remarkably reduce the systolic pressure, diastolic pressure and mean arterial pressure of spontaneous hypertensive rats (P < 0.05 or P < 0.01). The low, middle dose can reduce the heart rate of rats (P < 0.01). The low dose can effectively inhibit the left ventricle indexes (P < 0.05). The Tiangou Jiangya capsule has no markedly effects on the renin-angiotensin-aldosterone system (RAAS) activity and urinary output of rats.
  
  
  CONCLUSIONS
  The results indicate that the Tiangou Jiangya capsule has evident effect of lowering blood pressure of rats, which is related to reducing heart rate, heart ventricle indexes, and has no effect on the RAAS and diuresis.
authors.affiliation: Institute of Chinese Materia Medica, China Academy of Traditional Chinese Medicine Sciences, Beijing 100700, China.
authors.forename: Yujie
authors.initials: Y
authors.lastname: Li
authors.forename: Qing
authors.initials: Q
authors.lastname: Yang
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Weng
authors.forename: Ying
authors.initials: Y
authors.lastname: Chen
authors.forename: Dan
authors.initials: D
authors.lastname: Li
authors.forename: Lijuan
authors.initials: L
authors.lastname: Zou
authors.forename: Xiaoxin
authors.initials: X
authors.lastname: Zhu
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D001592:Benzyl Alcohols / Q000494:pharmacology* / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D004195:Disease Models, Animal; D004231:Diuresis / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use; D005419:Flavonoids / Q000494:pharmacology* / Q000627:therapeutic use*; D005663:Furans / Q000494:pharmacology* / Q000627:therapeutic use*; D005960:Glucosides / Q000494:pharmacology* / Q000627:therapeutic use*; D006339:Heart Rate / Q000187:drug effects; D006973:Hypertension / Q000188:drug therapy*; D017705:Lignans / Q000494:pharmacology* / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D012084:Renin-Angiotensin System / Q000187:drug effects; D016277:Ventricular Function, Left / Q000187:drug effects
chemical_list: D000959:Antihypertensive Agents; D001592:Benzyl Alcohols; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D005663:Furans; D005960:Glucosides; D017705:Lignans; C560376:Tiangou