title: Altered circadian rhythm of melatonin concentrations in hypocretin-deficient men.
abstract: Hypocretin deficiency causes narcolepsy. It is unknown whether melatonin secretion is affected in this sleep disorder. Therefore, in both narcolepsy patients and matched controls, the authors measured plasma melatonin levels hourly for 24 h before and after 5 days of sodium oxybate (SXB) administration. Although mean melatonin concentrations were similar between patients and controls, in narcoleptics the percentage of 24-h melatonin secreted during the daytime was significantly higher, and melatonin secretion exhibited a weaker coupling to sleep. SXB did not affect melatonin secretion. These findings suggest that hypocretin deficiency might disturb both the circadian control of melatonin release and its temporal association with sleep.
authors.affiliation: Department of Neurology, Leiden University Medical Centre, Leiden, The Netherlands. c.e.h.m.donjacour@lumc.nl
authors.forename: Claire E H M
authors.initials: CE
authors.lastname: Donjacour
authors.forename: Andries
authors.initials: A
authors.lastname: Kalsbeek
authors.forename: Sebastiaan
authors.initials: S
authors.lastname: Overeem
authors.forename: Gert Jan
authors.initials: GJ
authors.lastname: Lammers
authors.forename: Paul
authors.initials: P
authors.lastname: Pévet
authors.forename: Béatrice
authors.initials: B
authors.lastname: Bothorel
authors.forename: Hanno
authors.initials: H
authors.lastname: Pijl
authors.forename: N Ahmad
authors.initials: NA
authors.lastname: Aziz
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002940:Circadian Rhythm / Q000502:physiology*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000172:deficiency*; D008297:Male; D008550:Melatonin / Q000097:blood* / Q000378:metabolism; D009290:Narcolepsy / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*; D009479:Neuropeptides / Q000172:deficiency*; D000068797:Orexins; D012890:Sleep / Q000187:drug effects / Q000502:physiology; D020178:Sleep Disorders, Circadian Rhythm / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D012978:Sodium Oxybate / Q000008:administration & dosage
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D000068797:Orexins; D012978:Sodium Oxybate; D008550:Melatonin