title: Crystal structure of human enterovirus 71.
abstract: Enterovirus 71 is a picornavirus associated with fatal neurological illness in infants and young children. Here, we report the crystal structure of enterovirus 71 and show that, unlike in other enteroviruses, the "pocket factor," a small molecule that stabilizes the virus, is partly exposed on the floor of the "canyon." Thus, the structure of antiviral compounds may require a hydrophilic head group designed to interact with residues at the entrance of the pocket.
authors.affiliation: Department of Biological Sciences, Purdue University, West Lafayette, IN 47907, USA.
authors.forename: Pavel
authors.initials: P
authors.lastname: Plevka
authors.forename: Rushika
authors.initials: R
authors.lastname: Perera
authors.forename: Jane
authors.initials: J
authors.lastname: Cardosa
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Kuhn
authors.forename: Michael G
authors.initials: MG
authors.lastname: Rossmann
mesh_terms: D002213:Capsid / Q000737:chemistry / Q000378:metabolism / Q000648:ultrastructure; D036022:Capsid Proteins / Q000737:chemistry* / Q000378:metabolism; D018360:Crystallography, X-Ray; D029821:Enterovirus A, Human / Q000737:chemistry* / Q000378:metabolism / Q000648:ultrastructure*; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D008958:Models, Molecular; D011487:Protein Conformation; D011991:Receptors, Virus / Q000378:metabolism
chemical_list: D036022:Capsid Proteins; D011991:Receptors, Virus