title: A case of chronic active Epstein-Barr virus infection mimicking adult-onset Still's disease.
abstract: An 83-year-old man was diagnosed with adult-onset Still's disease (AOSD) based on clinical and laboratory findings. However, glucocorticoid had little effect. Epstein-Barr virus (EBV)-DNA was detected in peripheral blood, and autopsy findings confirmed a diagnosis of chronic active EBV infection (CAEBV). CAEBV mimics AOSD, and the presence of articular involvement and leukocytosis does not exclude the possibility of CAEBV. CAEBV should be included in the differential diagnosis of AOSD, and measurement of EBV-DNA is essential.
authors.affiliation: Department of Internal Medicine, Osaka City Sumiyoshi Hospital, 1-2-16 Higashikagaya, Suminoeku, Osaka, Osaka, 559-0012, Japan. kmyoshi@rr.iij4u.or.jp
authors.forename: Katsunobu
authors.initials: K
authors.lastname: Yoshioka
authors.forename: Hiroko
authors.initials: H
authors.lastname: Fukushima
authors.forename: Naomi
authors.initials: N
authors.lastname: Ishii
authors.forename: Akiko
authors.initials: A
authors.lastname: Kita
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Hanioka
authors.forename: Mieko
authors.initials: M
authors.lastname: Minami
authors.forename: Takeshi
authors.initials: T
authors.lastname: Inoue
authors.forename: Keiko
authors.initials: K
authors.lastname: Yamagami
mesh_terms: D000369:Aged, 80 and over; D002908:Chronic Disease; D004279:DNA, Viral / Q000097:blood; D003937:Diagnosis, Differential; D004351:Drug Resistance; D020031:Epstein-Barr Virus Infections / Q000097:blood / Q000175:diagnosis*; D017809:Fatal Outcome; D005938:Glucocorticoids / Q000627:therapeutic use; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D007596:Joints / Q000473:pathology; D007963:Leukocytes, Mononuclear / Q000473:pathology / Q000821:virology; D007964:Leukocytosis / Q000175:diagnosis; D008297:Male; D016706:Still's Disease, Adult-Onset / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D004279:DNA, Viral; D005938:Glucocorticoids