title: De novo membranoproliferative glomerulonephritis III in a renal transplant patient: case report and review of the literature.
abstract: Idiopathic membranoproliferative glomerulonephritis (MPGN) is a rare cause of renal failure with a cumulative incidence of 0.3% of all ESRD and 4% of all primary glomerulonephritis for types I and II. Membranoproliferative glomerulonephritis type III is more uncommon and idiopathic de novo MPGN III in a renal transplant patient has not been reported. We present the case of a 57-year old white female patient with a diagnosis of lithium toxicity as cause of end stage renal disease (ESRD) who developed MPGN III in her allograft 6 years after a renal transplant. Despite treatment, she progressed to ESRD within four and a half years from the time of diagnosis.
authors.affiliation: Department of Medicine, Washington University School of Medicine in St. Louis, St. Louis, MO 63110, USA. ajava@dom.wustl.edu
authors.forename: Anuja
authors.initials: A
authors.lastname: Java
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Gaut
authors.forename: Daniel C
authors.initials: DC
authors.lastname: Brennan
mesh_terms: D018692:Antimanic Agents / Q000633:toxicity; D001714:Bipolar Disorder / Q000188:drug therapy; D005260:Female; D015432:Glomerulonephritis, Membranoproliferative / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000139:chemically induced / Q000601:surgery; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000473:pathology; D008094:Lithium / Q000633:toxicity; D008875:Middle Aged; D013997:Time Factors
chemical_list: D018692:Antimanic Agents; D008094:Lithium