title: Avascular necrosis of bilateral femoral heads in a patient with Fabry's disease.
abstract: The underlying cause of avascular necrosis (AVN) of the femoral head is often not apparent. We report the case of a 26 year old builder with a four month history of bilateral hip pain, and a diagnosis of bilateral femoral head avascular necrosis. Fabry's disease was identified as the probable cause. Since 2001, enzyme replacement therapy for Fabry's disease has become available, with a potential to influence the disease process, and this is of potential importance to clinicians treating AVN.
authors.affiliation: Trauma and Orthopaedic Department, Kerry General Hospital, Tralee, Kerry, Ireland. fneill@hotmail.com
authors.forename: Francis
authors.initials: F
authors.lastname: O'Neill
authors.forename: John
authors.initials: J
authors.lastname: Rice
mesh_terms: D000328:Adult; D056947:Enzyme Replacement Therapy; D000795:Fabry Disease / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D005270:Femur Head / Q000473:pathology*; D005271:Femur Head Necrosis / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D008297:Male; D000519:alpha-Galactosidase / Q000627:therapeutic use
chemical_list: D000519:alpha-Galactosidase