title: Incidence, risk factors and management of delayed wound dehiscence after craniotomy for tumor resection.
abstract: Dehiscence after a wound has healed is a known complication of craniotomy for tumor resection. We conducted a retrospective analysis of 64 patients who underwent craniotomy for tumor resection followed by radiation or radiosurgery between 2006 and 2010. Five patients (7.8%) were identified who showed wound dehiscence from two to eight months after the craniotomy wound had healed. Four patients had previously undergone additional craniotomies, additional radiosurgery or had been treated with the anti-angiogenic factor, bevacizumab. These treatments may be risk factors for developing delayed dehiscence and, in combination, may potentiate local wound healing problems. Potential mechanisms and management strategies are discussed.
authors.affiliation: Memorial Neuroscience Center, Memorial Hospital Jacksonville, 3627 University Boulevard South, Suite 355, Jacksonville, FL 32216, USA. kbarami@yahoo.com
authors.forename: Kaveh
authors.initials: K
authors.lastname: Barami
authors.forename: Rui
authors.initials: R
authors.lastname: Fernandes
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000601:surgery; D015331:Cohort Studies; D003399:Craniotomy / Q000009:adverse effects*; D005260:Female; D005910:Glioma / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology* / Q000209:etiology* / Q000628:therapy; D012307:Risk Factors; D055752:Small Cell Lung Carcinoma / Q000601:surgery; D013529:Surgical Wound Dehiscence / Q000453:epidemiology* / Q000209:etiology* / Q000628:therapy; D013997:Time Factors