title: Sebaceous gland carcinoma of the head and neck: the Princess Margaret Hospital experience.
abstract: BACKGROUND
  The purpose of this study was to identify prognostic factors predicting outcomes in sebaceous gland carcinomas.
  
  
  METHODS
  We conducted a retrospective medical chart review of patients with sebaceous carcinomas of periorbital (n = 33) and extraorbital sites (n = 13).
  
  
  RESULTS
  Patients with periorbital tumors had higher recurrence rates than did patients with extraorbital tumors (64% vs 23%; p = .032). Patients who were older than 60 years (p = .035) and had lower eyelid tumors (p < .0001) had a lower disease-free survival rate than did patients with upper eyelid tumors. Patients with sebaceous carcinomas had a high rate (60%) of occult lymph node metastases.
  
  
  CONCLUSIONS
  Periorbital tumors are associated with poorer outcomes than are extraorbital tumors. Lower eyelid carcinomas have the worst prognosis and should be treated more aggressively. Our findings of a high incidence of occult neck disease and a high rate of regional recurrence in patients with sebaceous carcinomas support the consideration of prophylactic elective neck dissections for treating such patients.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Princess Margaret Hospital, University of Toronto, Toronto, Ontario, Canada.
authors.forename: Boban M
authors.initials: BM
authors.lastname: Erovic
authors.forename: David P
authors.initials: DP
authors.lastname: Goldstein
authors.forename: Dae
authors.initials: D
authors.lastname: Kim
authors.forename: Ayman
authors.initials: A
authors.lastname: Al Habeeb
authors.forename: John
authors.initials: J
authors.lastname: Waldron
authors.forename: Danny
authors.initials: D
authors.lastname: Ghazarian
authors.forename: Jonathan C
authors.initials: JC
authors.lastname: Irish
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018572:Disease-Free Survival; D005260:Female; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology; D009918:Orbital Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D011379:Prognosis; D012189:Retrospective Studies; D012626:Sebaceous Gland Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D015996:Survival Rate