title: Early-life gut microbiota under physiological and pathological conditions: the central role of combined meta-omics-based approaches.
abstract: The establishment of gut microbiota immediately after birth is modulated by different mechanisms that can be considered specific determinants of temporal and spatial variability. Over the last few years, molecular methods have been offering a complementary support to the classical microbiology, often underpowered by its inability to provide unbiased representation of gut microbiota. The advent of high-throughput-omics-based methods has opened new avenues in the knowledge of the gut ecosystem by shedding light on its shape and modulation. Such methods may unveil taxa distribution, role and density of microbial habitants, hence highlighting individual phenotyping (physiological traits) and their relationship with gut dysbiosis, inflammation processes, metabolic disorders (pathological conditions). Synergic meta-omics or "systems biology"-based approaches may concur in providing advanced information on microbiota establishment and pathogen control. During early-life stages this massive amount of data may provide gut microbiota descriptive and functional charts which can be exploited to perform a good practice in childcare and pediatrics, thus providing nutraceutical benefits and endorsing healthy development and aging. This article is part of a Special Issue entitled: Translational Proteomics.
authors.affiliation: Parasitology Unit, Department of Laboratory Medicine, Bambino Gesù Children's Hospital, IRCCS, Piazza Sant'Onofrio 4, Rome, 00165, Italy.
authors.forename: Federica
authors.initials: F
authors.lastname: Del Chierico
authors.forename: Pamela
authors.initials: P
authors.lastname: Vernocchi
authors.forename: Luigi
authors.initials: L
authors.lastname: Bonizzi
authors.forename: Rita
authors.initials: R
authors.lastname: Carsetti
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Castellazzi
authors.forename: Bruno
authors.initials: B
authors.lastname: Dallapiccola
authors.forename: Willem
authors.initials: W
authors.lastname: de Vos
authors.forename: Maria Elisabetta
authors.initials: ME
authors.lastname: Guerzoni
authors.forename: Melania
authors.initials: M
authors.lastname: Manco
authors.forename: Gian Luigi
authors.initials: GL
authors.lastname: Marseglia
authors.forename: Maurizio
authors.initials: M
authors.lastname: Muraca
authors.forename: Paola
authors.initials: P
authors.lastname: Roncada
authors.forename: Guglielmo
authors.initials: G
authors.lastname: Salvatori
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Signore
authors.forename: Andrea
authors.initials: A
authors.lastname: Urbani
authors.forename: Lorenza
authors.initials: L
authors.lastname: Putignani
mesh_terms: D000375:Aging / Q000378:metabolism / Q000473:pathology; D000818:Animals; D006801:Humans; D007410:Intestinal Diseases / Q000378:metabolism / Q000382:microbiology / Q000473:pathology; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000382:microbiology; D020543:Proteome / Q000378:metabolism*; D040901:Proteomics
chemical_list: D020543:Proteome