title: New constituents from the rhizomes of Egyptian Iris germanica L.
abstract: Chemical investigation of the methanolic extract of the rhizomes of Iris germanica L. (Iridaceae) afforded two new compounds; irigenin S (7) and iriside A (12), together with ten known compounds: stigmasterol (1), a-irone (2), γ-irone (3), 3-hydroxy-5-methoxyacetophenone (4), irilone (5), irisolidone (6), irigenin (8), stigmasterol-3-O-β-D-glucopyranoside (9), irilone 4'-O-β-D-glucopyranoside (10) and iridin (11). Their structures were established by UV, IR, 1D (¹H and ¹³C) and 2D (¹H-¹H COSY, HMQC, and HMBC) NMR spectroscopy, in addition to mass spectroscopic data and comparison with literature data. The methanolic extract was evaluated for its antimicrobial activity. Both the methanolic extract and the isolated flavonoids were tested for their anti-inflammatory activity.
authors.affiliation: Department of Pharmacognosy, Faculty of Pharmacy, Assiut University, Assiut 71526, Egypt.
authors.forename: Sabrin R M
authors.initials: SR
authors.lastname: Ibrahim
authors.forename: Gamal A
authors.initials: GA
authors.lastname: Mohamed
authors.forename: Nawal M
authors.initials: NM
authors.lastname: Al-Musayeib
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D004534:Egypt; D005557:Formaldehyde; D005658:Fungi / Q000187:drug effects; D031323:Iris Plant / Q000737:chemistry*; D007529:Isoflavones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008297:Male; D000432:Methanol / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D008956:Models, Chemical; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011897:Random Allocation; D051381:Rats; D027343:Rhizome / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D000935:Antifungal Agents; D007529:Isoflavones; D010936:Plant Extracts; D012997:Solvents; C572846:irigenin S; C572847:iriside A; D005557:Formaldehyde; D000432:Methanol