title: Graft dislocation and hypotony after Descemet's stripping automated endothelial keratoplasty in patients with previous glaucoma surgery.
abstract: OBJECTIVE
  To determine if patients with prior glaucoma surgery experience higher rates of postoperative graft dislocation after Descemet's stripping automated endothelial keratoplasty (DSAEK) and to determine if postoperative hypotony may be a risk factor in these patients.
  
  
  METHODS
  Retrospective, comparative analysis of an interventional case series.
  
  
  METHODS
  Eight hundred fifty-four eyes (67 eyes with prior glaucoma surgery and 787 controls) from 582 patients who underwent DSAEK at 1 institution between January 2005 and April 2011.
  
  
  METHODS
  Groups were compared with regard to preoperative, intraoperative, and postoperative parameters. Continuous variables were compared using the independent samples t test or Mann-Whitney U test. Categorical variables were compared using the chi-square test or Fisher exact test.
  
  
  METHODS
  Frequencies of postoperative graft dislocation and postoperative hypotony.
  
  
  RESULTS
  Study eyes before surgery differed from control eyes with regard to corneal thickness (768 vs. 655 μm; P<0.001) and intraocular pressure (13 vs. 16 mmHg; P<0.001). Postoperative graft dislocation occurred significantly more frequently in study eyes compared with control eyes (9% vs. 2%; P = 0.008). Among eyes in which dislocation occurred, postoperative hypotony was present in 5 study eyes (83%) and 0 control eyes.
  
  
  CONCLUSIONS
  Previous glaucoma surgery was associated with a significantly increased rate of graft dislocation compared with control eyes. Dislocation was related strongly to postoperative hypotony in eyes with prior glaucoma surgery.
  
  
  BACKGROUND
  Proprietary or commercial disclosure may be found after the references.
authors.affiliation: Devers Eye Institute, Portland, Oregon 97210, USA. jeffgoshe@gmail.com
authors.forename: Jeffrey M
authors.initials: JM
authors.lastname: Goshe
authors.forename: Mark A
authors.initials: MA
authors.lastname: Terry
authors.forename: Jennifer Y
authors.initials: JY
authors.lastname: Li
authors.forename: Michael D
authors.initials: MD
authors.lastname: Straiko
authors.forename: David
authors.initials: D
authors.lastname: Davis-Boozer
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D057111:Descemet Stripping Endothelial Keratoplasty; D005260:Female; D005901:Glaucoma / Q000601:surgery*; D020327:Glaucoma Drainage Implants; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D015814:Ocular Hypotension / Q000209:etiology*; D011183:Postoperative Complications; D055031:Primary Graft Dysfunction / Q000209:etiology*; D012189:Retrospective Studies; D012307:Risk Factors; D014130:Trabeculectomy