title: Macrophage inflammatory protein-1β and fibrinogen are synergistic predictive markers of prognosis of intermediate coronary artery lesions.
abstract: OBJECTIVE
  We tested the hypothesis that the plasma levels of fibrinogen and macrophage inflammatory protein (MIP)-1β are synergistic predictive markers of the prognosis of intermediate coronary artery lesions.
  
  
  METHODS
  A prospective study was performed on 670 patients with intermediate coronary artery lesions. Fibrinogen and MIP-1β were measured. Major adverse cardiac event (MACE) was defined as a composite of cardiovascular death, nonfatal myocardial infarction, revascularization and readmission due to angina pectoris.
  
  
  RESULTS
  During follow-up, 72 events occurred; 5 patients died, 7 patients suffered a nonfatal myocardial infarction, 11 patients underwent revascularization and 49 patients were readmitted for angina pectoris. In patients with above-median levels of MIP-1β, a 2.62-fold risk of a MACE [95% confidence interval (CI) 1.53-4.48] was predicted compared with patients with below-median levels of MIP-1β. However, the strongest risk prediction was achieved by assessing MIP-1β and fibrinogen together. After adjusting for traditional risk factors, a multivariate Cox proportional hazards analysis showed that patients with both MIP-1β and fibrinogen above the median had a 4.37-fold risk of a MACE (95% CI 1.89-10.11).
  
  
  CONCLUSIONS
  MIP-1β accurately predicted MACEs. Considering MIP-1β and fibrinogen together may improve long-term risk assessment. These two biomarkers have a synergistic effect for assessing long-term risk in patients with intermediate coronary artery lesions.
authors.affiliation: Beijing Anzhen Hospital, Capital Medical University, 2 Anzhen Road, Beijing, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Xu
authors.forename: Shuzheng
authors.initials: S
authors.lastname: Lv
authors.forename: Yundai
authors.initials: Y
authors.lastname: Chen
authors.forename: Xiantao
authors.initials: X
authors.lastname: Song
authors.forename: Zening
authors.initials: Z
authors.lastname: Jin
authors.forename: Fei
authors.initials: F
authors.lastname: Yuan
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhou
authors.forename: Hong
authors.initials: H
authors.lastname: Li
mesh_terms: D000368:Aged; D000787:Angina Pectoris / Q000209:etiology / Q000401:mortality; D015415:Biomarkers / Q000378:metabolism; D054407:Chemokine CCL4 / Q000378:metabolism*; D023921:Coronary Stenosis / Q000175:diagnosis* / Q000401:mortality; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology / Q000401:mortality; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D016019:Survival Analysis
chemical_list: D015415:Biomarkers; D054407:Chemokine CCL4; D005340:Fibrinogen