title: Relationship between serum interleukin-1beta levels and acute phase response proteins in patients with familial Mediterranean fever.
abstract: BACKGROUND
  The aim of this study was to investigate whether serum levels of interleukin-1beta (IL-1beta) has any possible correlation on inflammatory parameters such as C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and fibrinogen concentration in patients with familial Mediterranean fever (FMF) patients during attack-free period.
  
  
  METHODS
  The serum levels of IL-1beta, as an indicator of cytokines status, and the acute phase response proteins, CRP, ESR and fibrinogen levels were evaluated in 35 attack-free patients with FMF and 25 healthy volunteers.
  
  
  RESULTS
  Serum IL-1beta levels were significantly higher in patients with FMF than control subjects (P = 0.018). There was no statistically significant difference in the serum levels of ESR, CRP and fibrinogen between two groups (P = 0.181, P = 0.816, P = 0.686, respectively). There was a significant correlation between IL-1beta and CRP (r = 0.513, P = 0.002) values of FMF group.
  
  
  CONCLUSIONS
  In conclusion, our results confirm the presence of increased IL-1beta levels in FMF patients during attack-free period. Serum IL-1beta values seems to correlate with CRP levels. The elevation of IL-1beta levels may be important in monitoring subclinical inflammation of attack free period in FMF patients.
authors.affiliation: Department of Physical Medicine and Rehabilitation, Ataturk University, Medical Faculty, Erzurum, Turkey.
authors.forename: Kadir
authors.initials: K
authors.lastname: Yildirim
authors.forename: Hulya
authors.initials: H
authors.lastname: Uzkeser
authors.forename: Mustafa
authors.initials: M
authors.lastname: Keles
authors.forename: Saliha
authors.initials: S
authors.lastname: Karatay
authors.forename: Ahmet
authors.initials: A
authors.lastname: Kiziltunc
authors.forename: Muhammet Dursun
authors.initials: MD
authors.lastname: Kaya
authors.forename: Abdulkadir
authors.initials: A
authors.lastname: Yildirim
mesh_terms: D000209:Acute-Phase Proteins / Q000378:metabolism*; D000210:Acute-Phase Reaction / Q000097:blood*; D000328:Adult; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D010505:Familial Mediterranean Fever / Q000097:blood*; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D053583:Interleukin-1beta / Q000097:blood*; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D000209:Acute-Phase Proteins; D053583:Interleukin-1beta; D005340:Fibrinogen; D002097:C-Reactive Protein