title: Antioxidant and anti-α-glucosidase compounds from the rhizome of Peltiphyllum peltatum (Torr.) Engl.
abstract: The antioxidant, anti-α-glucosidase and anticholinesterase effects of the alcohol extract of fresh underground rhizomes of Peltiphyllum peltatum were studied. A potent antioxidant activity accompanied by a selective α-glucosidase effect was observed for the crude extract. Further activity-guided fractionation (petroleum ether, chloroform, ethyl acetate, n-butanol and water) resulted in the identification of the ethyl acetate fraction with the highest antioxidant effect. Gallic acid, methyl-3-O-methyl gallate, catechin, gallocatechin, bergenin and 11-O-galloylbergenin were isolated from the ethyl acetate fraction. While all the isolated compounds did show a variable degree of radical scavenging effect, 11-O-galloylbergenin was identified as the selective α-glucosidase inhibitor. The isolation, structural elucidation and biological effects of these compounds are discussed.
authors.affiliation: Pharmacognosy Research Laboratories, Medway School of Science, University of Greenwich, Central Avenue, Chatham-Maritime, Kent, ME4 4 TB, UK. s.habtemariam@gre.ac.uk
authors.forename: Solomon
authors.initials: S
authors.lastname: Habtemariam
authors.forename: Raymond A
authors.initials: RA
authors.lastname: Cowley
mesh_terms: D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology*; D005591:Chemical Fractionation; D002851:Chromatography, High Pressure Liquid; D004791:Enzyme Inhibitors / Q000302:isolation & purification / Q000494:pharmacology; D065089:Glycoside Hydrolase Inhibitors; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D027343:Rhizome / Q000737:chemistry*; D031995:Saxifragaceae / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D010936:Plant Extracts