title: Effect of levosimendan injection on oxidative stress of rat myocardium.
abstract: This experiment was designed to investigate the effect of levosimendan injection on lipid peroxidation product malondialdehyde (MDA) and antioxidant glutathione (GSH) levels, and activities of antioxidant enzymes in myocardium of rats. Twenty male Wistar-albino rats were divided randomly into 2 study groups, each consisting of 10 rats. The animals in the first group were not treated with drug and served as control. It was found that the MDA and GSH levels decreased in levosimendan injected group. Superoxide dismutase, glutathione peroxidase, catalase and carbonic anhydrase enzyme activities were lower in levosimendan injected group than controls. It was concluded that lower tissue free radical level caused by levosimendan injection led to a lower antioxidant enzymes synthesis in the body and a decrease in the antioxidant enzyme activity and free radical scavenger level in myocardium of rat.
authors.affiliation: Department of Cardiovascular Surgery, Bezmi Alem Foundation University Hospital, İstanbul, Turkey. hbasel@mynet.com
authors.forename: Halil
authors.initials: H
authors.lastname: Basel
authors.forename: Servet
authors.initials: S
authors.lastname: Kavak
authors.forename: Halit
authors.initials: H
authors.lastname: Demir
authors.forename: Ismail
authors.initials: I
authors.lastname: Meral
authors.forename: Hasan
authors.initials: H
authors.lastname: Ekim
authors.forename: Hava
authors.initials: H
authors.lastname: Bektas
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D002256:Carbonic Anhydrases / Q000378:metabolism; D002316:Cardiotonic Agents / Q000494:pharmacology; D002374:Catalase / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D006321:Heart / Q000187:drug effects*; D006835:Hydrazones / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism*; D018384:Oxidative Stress / Q000187:drug effects*; D011724:Pyridazines / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D000077464:Simendan; D018709:Statistics, Nonparametric; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D000975:Antioxidants; D002316:Cardiotonic Agents; D006835:Hydrazones; D011724:Pyridazines; D000077464:Simendan; D008315:Malondialdehyde; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D002256:Carbonic Anhydrases; D005978:Glutathione