title: [Effects of Na-FA on gastrointestinal movement and gastric ulcer in mice].
abstract: OBJECTIVE
  To research the effects of Na-FA on gastrointestinal movement and gastriculcer in mice.
  
  
  METHODS
  Using charcoal powder as an indicator, the effects of FA-Na on bowel movement of mice was evaluated by determining the propulsive percent-age of charcoal powder in normal mice, inhibition of small intestinal propulsion model induced by Compound Diphenoxylate and spleen asthenia and diarrhea model caused by Rheum officinale Baill; The acute gastric ulcer model was induced by intragastric alcohol given orally, the protective effect of FA-Na given ahead on gastric injury was evaluated, the ulcer index and the inhibition ratio of ulcer was calculated.
  
  
  RESULTS
  FA-Na (intragastric administration) had inhibit effect on normal mice and diarrhea model caused by Rheum officinale, significantly synergetic effect on gastrointestinal asynersis induced by Compound Diphenoxylate, and protective effect on mice gastric mucosal injury cause by dehydrated alcohol. Compared with the positive control drug Ranitidine, the ulcer index and ulcer inhibition ratio large doses of FA-Na had no significant difference.
  
  
  CONCLUSIONS
  The acute toxicity of FA-Na is very low, it has the effects of antidiarrheal and anti-gastric ulcer.
authors.affiliation: Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650224, China. liyuemei5566@hotmail.com
authors.forename: Yue-Mei
authors.initials: YM
authors.lastname: Li
authors.forename: Bao-Cai
authors.initials: BC
authors.lastname: Li
authors.forename: Peng
authors.initials: P
authors.lastname: Li
authors.forename: Jian-Zhen
authors.initials: JZ
authors.lastname: Liu
authors.forename: Jia-Li
authors.initials: JL
authors.lastname: Cui
authors.forename: Zhan-Qing
authors.initials: ZQ
authors.lastname: Mei
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology* / Q000627:therapeutic use; D000930:Antidiarrheals / Q000494:pharmacology / Q000627:therapeutic use; D001578:Benzopyrans / Q000494:pharmacology* / Q000627:therapeutic use; D001835:Body Weight; D002244:Carbon / Q000737:chemistry; D002614:Chelating Agents / Q000494:pharmacology* / Q000627:therapeutic use; D003967:Diarrhea / Q000139:chemically induced / Q000188:drug therapy; D004157:Diphenoxylate; D004195:Disease Models, Animal; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects / Q000293:injuries; D005767:Gastrointestinal Diseases / Q000139:chemically induced / Q000188:drug therapy*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D041981:Gastrointestinal Tract / Q000187:drug effects*; D006812:Humic Substances; D008297:Male; D051379:Mice; D011899:Ranitidine / Q000494:pharmacology / Q000627:therapeutic use; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy / Q000517:prevention & control
chemical_list: D000897:Anti-Ulcer Agents; D000930:Antidiarrheals; D001578:Benzopyrans; D002614:Chelating Agents; D006812:Humic Substances; D004157:Diphenoxylate; D002244:Carbon; D011899:Ranitidine; C005023:fulvic acid