title: Interacting partners of AMPA-type glutamate receptors.
abstract: Glutamate is the principal excitatory neurotransmitter in the brain. The alpha-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic (AMPA) receptors, as one of several types of endogenous ionotropic glutamate receptors, mediate the fast excitatory synaptic transmission that is essential for information processing and integration in the mammalian brain. Modifications of AMPA receptors are assumed to be the molecular basis underlying learning and memory, and impairments of AMPA receptors cause certain neurological diseases, including epilepsy, autism spectrum disorders, and Alzheimer's disease. Thus, extensive studies have been conducted, and these have revealed a complex protein-protein network controlling the expression, trafficking, and function of AMPA receptors in neurons. Here, we summarize the interacting partners of AMPA-type glutamate receptors and the functional implications of these interactions.
authors.affiliation: State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Sciences, Peking University, Beijing 100871, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Cheng
authors.forename: Jie
authors.initials: J
authors.lastname: Dong
authors.forename: Yaxuan
authors.initials: Y
authors.lastname: Cui
authors.forename: Liecheng
authors.initials: L
authors.lastname: Wang
authors.forename: Bei
authors.initials: B
authors.lastname: Wu
authors.forename: Chen
authors.initials: C
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001927:Brain Diseases / Q000378:metabolism / Q000503:physiopathology; D018698:Glutamic Acid / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D018091:Receptors, AMPA / Q000378:metabolism* / Q000502:physiology; D013569:Synapses / Q000378:metabolism / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology
chemical_list: D018091:Receptors, AMPA; D018698:Glutamic Acid