title: Contribution of orodental status to the intensity of orofacial tardive dyskinesia: an interdisciplinary and video-based assessment.
abstract: BACKGROUND
  Tardive dyskinesia (TD) is a neurological motor complication eventually arising in one-third of patients chronically exposed to antipsychotic drugs. Some orodental peripheral factors have been reported to influence TD.
  
  
  OBJECTIVE
  To measure orodental factors such as temporomandibular joint function, static occlusal contacts, and denture condition, and attempt correlations with orofacial TD intensity.
  
  
  METHODS
  In this exploratory cross-sectional pilot study, 31 subjects between 30 and 75 years of age were divided in two groups displaying minimal to mild, or moderate to severe orofacial TD, respectively, and underwent a detailed oral, dental, and prosthetic evaluation to capture various aspects of oral health compared between the two groups. Blinded video-based TD ratings along a validated scale were obtained to compare dentulous and edentulous subjects, and contrast TD intensity in complete denture wearers with and without their own prostheses.
  
  
  RESULTS
  None of the factors examined tightly correlated with orofacial TD intensity. However, edentulism was associated with a higher median orofacial TD rating compared to the dentulous group (p = 0.001). Further, a significant intra-subject difference was observed in the edentulous subjects rated with their own complete dentures in place or not (p = 0.028), the dentures attenuating the mean orofacial ratings by 21.8 ± 7.3%.
  
  
  CONCLUSIONS
  Of all orodental factors considered, only edentulism and complete denture wearing influenced oral TD expression, calling for the close monitoring of the dental status in antipsychotic drug-exposed patients to prevent tooth loss. Further studies to measure the impact of an adequate prosthodontic rehabilitation in edentulous subjects with orofacial TD seem warranted.
authors.affiliation: Faculty of Dental Medicine, University of Montreal, Canada.
authors.forename: Philippe
authors.initials: P
authors.lastname: Girard
authors.forename: Claude
authors.initials: C
authors.lastname: Monette
authors.forename: Louise
authors.initials: L
authors.lastname: Normandeau
authors.forename: Tania
authors.initials: T
authors.lastname: Pampoulova
authors.forename: Pierre H
authors.initials: PH
authors.lastname: Rompré
authors.forename: Pierre
authors.initials: P
authors.lastname: de Grandmont
authors.forename: Pierre J
authors.initials: PJ
authors.lastname: Blanchet
mesh_terms: D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D005260:Female; D006306:Health Surveys; D006801:Humans; D008297:Male; D008875:Middle Aged; D009066:Mouth, Edentulous / Q000453:epidemiology* / Q000534:rehabilitation; D009069:Movement Disorders / Q000175:diagnosis* / Q000453:epidemiology*; D011569:Psychiatric Status Rating Scales; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D013705:Temporomandibular Joint Disorders / Q000175:diagnosis / Q000453:epidemiology; D014741:Video Recording / Q000379:methods*