title: Mitosis: short-circuiting spindle checkpoint signaling.
abstract: The spindle checkpoint forms an intricate signaling circuit to sense unattached kinetochores, to inhibit the anaphase-promoting complex/cyclosome (APC/C), and to delay anaphase onset. Using clever genetic experiments in the budding yeast, Lau and Murray define the endpoint of checkpoint signaling and provide key mechanistic insights into checkpoint inhibition of APC/C.
authors.affiliation: Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. xuelian.luo@utsouthwestern.edu
authors.forename: Xuelian
authors.initials: X
authors.lastname: Luo
authors.forename: Hongtao
authors.initials: H
authors.lastname: Yu
mesh_terms: D018797:Cell Cycle Proteins / Q000502:physiology*; D059566:M Phase Cell Cycle Checkpoints; D008938:Mitosis; D009687:Nuclear Proteins / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000166:cytology*; D029701:Saccharomyces cerevisiae Proteins / Q000502:physiology*
chemical_list: D018797:Cell Cycle Proteins; D009687:Nuclear Proteins; D029701:Saccharomyces cerevisiae Proteins