title: Isolation of NDM-1-producing Klebsiella pnemoniae in Ireland, July 2011.
abstract: We report the identification of New Delhi metallo-betalactamase 1 (NDM-1)-producing Klebsiella pnemoniae in Ireland. The organism was resistant to multiple antibiotic classes, including carbapenems, and PCR and sequencing confirmed the presence of the blaNDM-1 gene, carried on a 98 kb plasmid. The organism was isolated from an infant, who was born in India and moved to Ireland at the age of four months. This is the first reported isolation of an NDM-1-producing Enterobacteriaceae strain in Ireland.
authors.affiliation: Department of Clinical Microbiology, Children's University Hospital, Temple Street, Dublin, Ireland.
authors.forename: H
authors.initials: H
authors.lastname: McDermott
authors.forename: D
authors.initials: D
authors.lastname: Morris
authors.forename: E
authors.initials: E
authors.lastname: McArdle
authors.forename: G
authors.initials: G
authors.lastname: O'Mahony
authors.forename: S
authors.initials: S
authors.lastname: Kelly
authors.forename: M
authors.initials: M
authors.lastname: Cormican
authors.forename: R
authors.initials: R
authors.lastname: Cunney
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D015780:Carbapenems / Q000627:therapeutic use; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D006801:Humans; D007194:India; D007223:Infant; D007494:Ireland; D007710:Klebsiella Infections / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification*; D008826:Microbial Sensitivity Tests; D016133:Polymerase Chain Reaction; D017422:Sequence Analysis, DNA; D014195:Travel; D001618:beta-Lactamases / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D001618:beta-Lactamases; C552864:beta-lactamase NDM-1