title: Post-exercise cardiac troponin release is related to exercise training history.
abstract: Marathon running can increase circulating cardiac troponin above the diagnostic criteria for myocardial infarction. We determined whether prior-exercise experience (training history) might be related to the magnitude of immediate post-race troponin release following completion of the London Marathon in a group of non-elite runners. Using a prospective study design, 52 runners were recruited into either HIGH T-E (trained-experience) (n=27) or LOW T-E (n=25) groups. Cardiac troponin I (cTnI) release following race completion was compared between these 2 groups. To examine relationships between cTnI release and participant demographic and indices of prior training experience an additional 52 runners who did not meet the criteria for either the HIGH T-E or LOW T-E groups were also recruited. The combined data from all 104 runners was analysed using multivariate linear regression analysis. The results revealed a significant difference in post marathon circulating cTnI between LOW T-E runners (median: 0.11 µg/L; interquartile range [IQR]: 0.03-0.18 µg/L) and HIGH T-E runners (median: 0.03 µg/L; IQR 0.02-0.057 µg/L) (p<0.05). Average miles run per week in the last 3 years, a marker of total training experience, encompassing training volume and duration, was negatively associated with post-marathon cTnI release (p<0.001).In conclusion, exercise-induced cTnI release is strongly related to previous training experience.
authors.affiliation: Queen Mary University of London, Centre for Sports and Exercise Medicine, London, United Kingdom. ritan_mehta@hotmail.com
authors.forename: R
authors.initials: R
authors.lastname: Mehta
authors.forename: D
authors.initials: D
authors.lastname: Gaze
authors.forename: S
authors.initials: S
authors.lastname: Mohan
authors.forename: K L
authors.initials: KL
authors.lastname: Williams
authors.forename: V
authors.initials: V
authors.lastname: Sprung
authors.forename: K
authors.initials: K
authors.lastname: George
authors.forename: R
authors.initials: R
authors.lastname: Jeffries
authors.forename: Z
authors.initials: Z
authors.lastname: Hudson
authors.forename: M
authors.initials: M
authors.lastname: Perry
authors.forename: R
authors.initials: R
authors.lastname: Shave
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008131:London; D008297:Male; D008875:Middle Aged; D010807:Physical Endurance; D010809:Physical Fitness / Q000502:physiology*; D011446:Prospective Studies; D012146:Rest / Q000502:physiology*; D012420:Running / Q000502:physiology; D019210:Troponin I / Q000097:blood*
chemical_list: D019210:Troponin I