title: Recent advances in the study on resveratrol.
abstract: Appropriate long-term drinking of red wine is associated with a reduced risk for lifestyle-related diseases such as cardiovascular disease and cancer, making resveratrol, a constituent of grapes and various other plants, an attractive compound to be studied. Historically, resveratrol has been identified as a phytoalexin, antioxidant, cyclooxygenase (COX) inhibitor, peroxisome proliferator-activated receptor (PPAR) activator, endothelial nitric oxide synthase (eNOS) inducer, silent mating type information regulation 2 homolog 1 (SIRT1) activator, and more. Despite scepticism concerning the biological availability of resveratrol, a growing body of in vivo evidence indicates that resveratrol has protective effects in several stress and disease models. Here, we provide a review of the studies on resveratrol, especially with respect to COX, PPAR, and eNOS activities, and discuss its potential for promoting human health.
authors.affiliation: Department of Food Science and Nutrition, Nara Women's University, Kitauoyanishi-machi, Japan.
authors.forename: Rieko
authors.initials: R
authors.lastname: Nakata
authors.forename: Satoru
authors.initials: S
authors.lastname: Takahashi
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Inoue
mesh_terms: D000818:Animals; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology; D006801:Humans; D052250:Nitric Oxide Synthase Type III / Q000378:metabolism; D047492:Peroxisome Proliferator-Activated Receptors / Q000378:metabolism; D000077185:Resveratrol; D056564:Sirtuin 1 / Q000378:metabolism; D013267:Stilbenes / Q000494:pharmacology*
chemical_list: D016861:Cyclooxygenase Inhibitors; D047492:Peroxisome Proliferator-Activated Receptors; D013267:Stilbenes; D052250:Nitric Oxide Synthase Type III; D056564:Sirtuin 1; D000077185:Resveratrol