title: Longitudinal assessment of symptom severity among hospitalized elders diagnosed with cancer, heart failure, and chronic obstructive pulmonary disease.
abstract: BACKGROUND
  Pain, dyspnea, and anxiety are common among patients with cancer, heart failure (HF), and chronic obstructive pulmonary disease (COPD), yet little is known about the severity of symptoms over time.
  
  
  OBJECTIVE
  To determine the prevalence, severity, burden, and predictors of symptoms during the course of hospitalization and at 2 weeks after discharge.
  
  
  METHODS
  A prospective cohort study.
  
  
  METHODS
  A large academic university.
  
  
  METHODS
  Patients were 65 years or older with a primary diagnosis of cancer, COPD, or HF.
  
  
  METHODS
  Daily living skills and depression were recorded at enrollment. Symptoms were assessed daily and 2 weeks postdischarge.
  
  
  RESULTS
  At baseline, most participants reported moderate/severe pain (54%), dyspnea (53%), and anxiety (62%). Almost two-thirds (64%) had 2 or more symptoms at a moderate/severe level. The prevalence of moderate/severe symptoms decreased at the 24-hour assessment (pain = 42%, dyspnea = 45%, anxiety = 55%, burden = 55%) and again at follow-up (pain = 28%, dyspnea = 27%, anxiety = 25%, burden = 30%). While there was no association between primary diagnosis and symptom severity at baseline or 24-hour assessment, at 2-week follow-up, a higher percentage of patients with COPD had moderate/severe pain (54%, χ(2) = 22.0, P = 0.001), dyspnea (45%, χ(2) = 9.3, P = 0.05), and overall symptom burden (55%, χ(2) = 25.9, P = 0.001) than those with cancer (pain = 22%, dyspnea = 16%, symptom burden = 16%) or HF (pain = 25%, dyspnea = 24%, symptom burden = 28%). Predictors of symptom burden at follow-up were COPD (odds ratio [OR] = 7.5; 95% confidence interval [CI] = 2.0, 27.7) and probable depression (OR = 6.1; 95% CI = 2.1, 17.8).
  
  
  CONCLUSIONS
  The majority of inpatients with chronic illness reported high severity of symptoms. Symptoms improved over time but many patients, particularly those with COPD, had high symptom severity at follow-up.
authors.affiliation: Palliative Care Program, University of California San Francisco, San Francisco, CA 94143-0903, USA. stevep@medicine.ucsf.edu
authors.forename: Steven Z
authors.initials: SZ
authors.lastname: Pantilat
authors.forename: David L
authors.initials: DL
authors.lastname: O'Riordan
authors.forename: Suzanne L
authors.initials: SL
authors.lastname: Dibble
authors.forename: C Seth
authors.initials: CS
authors.lastname: Landefeld
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D006333:Heart Failure / Q000401:mortality / Q000473:pathology*; D006801:Humans; D007297:Inpatients; D007902:Length of Stay; D009369:Neoplasms / Q000401:mortality / Q000473:pathology*; D010146:Pain / Q000473:pathology; D010147:Pain Measurement; D015995:Prevalence; D011446:Prospective Studies; D029424:Pulmonary Disease, Chronic Obstructive / Q000401:mortality / Q000473:pathology*; D012720:Severity of Illness Index; D013997:Time Factors; D014481:United States