title: Modelling the influence of foot-and-mouth disease vaccine antigen stability and dose on the bovine immune response.
abstract: Foot and mouth disease virus causes a livestock disease of significant global socio-economic importance. Advances in its control and eradication depend critically on improvements in vaccine efficacy, which can be best achieved by better understanding the complex within-host immunodynamic response to inoculation. We present a detailed and empirically parametrised dynamical mathematical model of the hypothesised immune response in cattle, and explore its behaviour with reference to a variety of experimental observations relating to foot and mouth immunology. The model system is able to qualitatively account for the observed responses during in-vivo experiments, and we use it to gain insight into the incompletely understood effect of single and repeat inoculations of differing dosage using vaccine formulations of different structural stability.
authors.affiliation: Institute for Animal Health, Pirbright, Woking, United Kingdom. David.Schley@iah.ac.uk
authors.forename: David
authors.initials: D
authors.lastname: Schley
authors.forename: Reiko J
authors.initials: RJ
authors.lastname: Tanaka
authors.forename: Kritsada
authors.initials: K
authors.lastname: Leungchavaphongse
authors.forename: Vahid
authors.initials: V
authors.lastname: Shahrezaei
authors.forename: John
authors.initials: J
authors.lastname: Ward
authors.forename: Clare
authors.initials: C
authors.lastname: Grant
authors.forename: Bryan
authors.initials: B
authors.lastname: Charleston
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Rhodes
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000276:immunology*; D002417:Cattle / Q000276:immunology*; D003198:Computer Simulation; D004306:Dose-Response Relationship, Immunologic; D005536:Foot-and-Mouth Disease / Q000276:immunology* / Q000821:virology*; D007117:Immunization, Secondary; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D018448:Models, Immunological; D012680:Sensitivity and Specificity; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors; D014611:Vaccination; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D000956:Antigens, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D014765:Viral Vaccines