title: Basic science and surgical treatment options for articular cartilage injuries of the knee.
abstract: The complex structure of articular cartilage allows for diverse knee function throughout range of motion and weight bearing. However, disruption to the structural integrity of the articular surface can cause significant morbidity. Due to an inherently poor regenerative capacity, articular cartilage defects present a treatment challenge for physicians and therapists. For many patients, a trial of nonsurgical treatment options is paramount prior to surgical intervention. In instances of failed conservative treatment, patients can undergo an array of palliative, restorative, or reparative surgical procedures to treat these lesions. Palliative methods include debridement and lavage, while restorative techniques include marrow stimulation. For larger lesions involving subchondral bone, reparative procedures such as osteochondral grafting or autologous chondrocyte implantation are considered. Clinical success not only depends on the surgical techniques but also requires strict adherence to rehabilitation guidelines. The purpose of this article is to review the basic science of articular cartilage and to provide an overview of the procedures currently performed at our institution for patients presenting with symptomatic cartilage lesions.
authors.forename: Elizabeth S
authors.initials: ES
authors.lastname: Tetteh
authors.forename: Sarvottam
authors.initials: S
authors.lastname: Bajaj
authors.forename: Neil S
authors.initials: NS
authors.lastname: Ghodadra
mesh_terms: D002357:Cartilage Diseases / Q000453:epidemiology / Q000473:pathology / Q000601:surgery*; D002358:Cartilage, Articular / Q000293:injuries / Q000473:pathology / Q000601:surgery*; D019902:Chondrocytes / Q000637:transplantation; D006801:Humans; D007718:Knee Injuries / Q000453:epidemiology / Q000473:pathology / Q000601:surgery*; D014481:United States / Q000453:epidemiology