title: Bioinspired organocatalytic asymmetric reactions.
abstract: Several small organic molecule catalysts are reminiscent of natural enzymes in their mode of action and substrate interaction/activation. This striking similarity has been a great source of inspiration for the development of new organocatalytic asymmetric processes. A few representative examples, mostly dealing with catalysts interacting through multiple hydrogen-bonds (synthetic oxyanion holes), are highlighted in this perspective.
authors.affiliation: Department of Organic Chemistry A. Mangini, Faculty of Industrial Chemistry, University of Bologna, V. Risorgimento 4, 40136 Bologna, Italy. luca.bernardi2@unibo.it
authors.forename: Luca
authors.initials: L
authors.lastname: Bernardi
authors.forename: Mariafrancesca
authors.initials: M
authors.lastname: Fochi
authors.forename: Mauro
authors.initials: M
authors.lastname: Comes Franchini
authors.forename: Alfredo
authors.initials: A
authors.lastname: Ricci
mesh_terms: D000586:Amination; D040761:Biomimetic Materials / Q000737:chemistry*; D002384:Catalysis; D020134:Catalytic Domain; D003500:Cyclization; D004950:Esterases / Q000737:chemistry; D006860:Hydrogen Bonding; D011485:Protein Binding; D057057:Serine Proteases / Q000737:chemistry; D013237:Stereoisomerism; D013890:Thiourea / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry; D014508:Urea / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D014508:Urea; D004950:Esterases; D057057:Serine Proteases; D013890:Thiourea