title: Non-infectious orbital vasculitides.
abstract: Non-infectious vasculitides comprise a large number of diseases. Many of these diseases can cause inflammation within the orbit and a clinical presentation, which mimics numerous other processes. Orbital disease can often be the initial presentation of a systemic process and early diagnosis can help prevent long-term, potentially fatal consequences. The evaluation and treatment of non-infectious orbital vasculitides are often complicated and require a thorough understanding of the disease and underlying systemic associations. The long-term prognosis visually and systemically must be weighed against the risks and benefits of the treatment regimen. A large variety of corticosteroid formulations currently exist and are the mainstay of initial treatment. Traditional steroid-sparing immunosuppressive agents are also an important arsenal against these vasculitides. Recently, a new class of drugs called biologics, which target the various mediators of the inflammation cascade, may potentially provide more effective and less toxic treatment. This review aims to synthesize the current literature on non-infectious orbital vasculitides.
authors.affiliation: Kresge Eye Institute, Wayne State University School of Medicine, Detroit, MI, USA.
authors.forename: B
authors.initials: B
authors.lastname: Perumal
authors.forename: E H
authors.initials: EH
authors.lastname: Black
authors.forename: F
authors.initials: F
authors.lastname: Levin
authors.forename: J J
authors.initials: JJ
authors.lastname: Servat
mesh_terms: D015267:Churg-Strauss Syndrome / Q000175:diagnosis / Q000188:drug therapy; D003882:Dermatomyositis / Q000175:diagnosis / Q000188:drug therapy; D003937:Diagnosis, Differential; D005938:Glucocorticoids / Q000627:therapeutic use; D014890:Granulomatosis with Polyangiitis / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D009080:Mucocutaneous Lymph Node Syndrome / Q000175:diagnosis / Q000188:drug therapy; D009916:Orbital Diseases / Q000175:diagnosis* / Q000188:drug therapy; D010488:Polyarteritis Nodosa / Q000175:diagnosis / Q000188:drug therapy; D056647:Systemic Vasculitis / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents