title: A pivotal role of GSK-3 in synaptic plasticity.
abstract: Glycogen synthase kinase-3 (GSK-3) has many cellular functions. Recent evidence suggests that it plays a key role in certain types of synaptic plasticity, in particular a form of long-term depression (LTD) that is induced by the synaptic activation of N-methyl-D-aspartate receptors (NMDARs). In the present article we summarize what is currently known concerning the roles of GSK-3 in synaptic plasticity at both glutamatergic and GABAergic synapses. We summarize its role in cognition and speculate on how alterations in the synaptic functioning of GSK-3 may be a major factor in certain neurodegenerative disorders.
authors.affiliation: MRC Centre for Synaptic Plasticity, University of Bristol Bristol, UK.
authors.forename: Clarrisa A
authors.initials: CA
authors.lastname: Bradley
authors.forename: Stéphane
authors.initials: S
authors.lastname: Peineau
authors.forename: Changiz
authors.initials: C
authors.lastname: Taghibiglou
authors.forename: Celine S
authors.initials: CS
authors.lastname: Nicolas
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Whitcomb
authors.forename: Zuner A
authors.initials: ZA
authors.lastname: Bortolotto
authors.forename: Bong-Kiun
authors.initials: BK
authors.lastname: Kaang
authors.forename: Kwangwook
authors.initials: K
authors.lastname: Cho
authors.forename: Yu Tian
authors.initials: YT
authors.lastname: Wang
authors.forename: Graham L
authors.initials: GL
authors.lastname: Collingridge