title: Metal-organic frameworks for the storage and delivery of biologically active hydrogen sulfide.
abstract: Hydrogen sulfide is an extremely toxic gas that is also of great interest for biological applications when delivered in the correct amount and at the desired rate. Here we show that the highly porous metal-organic frameworks with the CPO-27 structure can bind the hydrogen sulfide relatively strongly, allowing the storage of the gas for at least several months. Delivered gas is biologically active in preliminary vasodilation studies of porcine arteries, and the structure of the hydrogen sulfide molecules inside the framework has been elucidated using a combination of powder X-ray diffraction and pair distribution function analysis.
authors.affiliation: School of Chemistry, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9ST, Scotland, UK.
authors.forename: Phoebe K
authors.initials: PK
authors.lastname: Allan
authors.forename: Paul S
authors.initials: PS
authors.lastname: Wheatley
authors.forename: David
authors.initials: D
authors.lastname: Aldous
authors.forename: M Infas
authors.initials: MI
authors.lastname: Mohideen
authors.forename: Chiu
authors.initials: C
authors.lastname: Tang
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Hriljac
authors.forename: Ian L
authors.initials: IL
authors.lastname: Megson
authors.forename: Karena W
authors.initials: KW
authors.lastname: Chapman
authors.forename: Guy
authors.initials: G
authors.lastname: De Weireld
authors.forename: Sebastian
authors.initials: S
authors.lastname: Vaesen
authors.forename: Russell E
authors.initials: RE
authors.lastname: Morris
mesh_terms: D000818:Animals; D003331:Coronary Vessels / Q000187:drug effects / Q000502:physiology; D004337:Drug Carriers / Q000008:administration & dosage* / Q000737:chemistry; D004355:Drug Stability; D006862:Hydrogen Sulfide / Q000008:administration & dosage* / Q000737:chemistry; D066298:In Vitro Techniques; D033362:Powder Diffraction; D013552:Swine; D014664:Vasodilation / Q000187:drug effects; D014961:X-Ray Diffraction; D017967:Zinc Compounds / Q000008:administration & dosage* / Q000737:chemistry
chemical_list: D004337:Drug Carriers; D017967:Zinc Compounds; D006862:Hydrogen Sulfide