title: [Clinical epidemiology and prevention of contact allergies. The Information Network of Departments of Dermatology (IVDK) as a register and surveillance system].
abstract: A total of 56 departments of dermatology from Germany, Austria, and Switzerland collaborate to study the clinical epidemiology of contact allergies (CA). Data generated in the course of the diagnostic work-up of CA (e.g., patch test data) have been stored since 1989 in the data center in Göttingen, Germany, including data for more than 200,000 patients (March 2011). These data can be used as a register and as a surveillance system. Analysis of the register may identify and quantify risk factors of sensitization to an allergen, which is exemplified with the case of the allergen para-phenylenediamine. It turned out that-in addition to the risk factor hair dyeing-other important risk factors must be considered. In contrast, data collected every 6 months (from approximately 6,000 patients) allow for time-trend analyses of allergens, thus, identifying allergens of concern, which is of utmost importance for early preventive intervention. Here, the epidemiology of allergies to epoxy resins serves as an example. Continuous monitoring of contact allergens will also be mandatory in the future, as the CA premarketing screening systems will have imperfect predictive values with regard to human CA risk. Unfortunately, the (current) national regulatory framework severely hampers clinical surveillance/epidemiology of contact sensitization and, thus, prevention of contact allergy.
authors.affiliation: Informationsverbund Dermatologischer Kliniken, Universitätsmedizin Göttingen, Von Siebold Str. 3, 37075, Göttingen, Deutschland. aschnuc@gwdg.de
authors.forename: A
authors.initials: A
authors.lastname: Schnuch
authors.forename: W
authors.initials: W
authors.lastname: Uter
authors.forename: H
authors.initials: H
authors.lastname: Lessmann
authors.forename: J
authors.initials: J
authors.lastname: Geier
mesh_terms: D000328:Adult; D001317:Austria; D004396:Coloring Agents / Q000009:adverse effects; D015897:Comorbidity; D003429:Cross Reactions / Q000276:immunology; D003430:Cross-Sectional Studies; D017449:Dermatitis, Allergic Contact / Q000453:epidemiology* / Q000517:prevention & control*; D009783:Dermatitis, Occupational / Q000453:epidemiology* / Q000517:prevention & control*; D004853:Epoxy Resins / Q000009:adverse effects; D005260:Female; D005659:Fungicides, Industrial / Q000009:adverse effects; D005858:Germany; D006306:Health Surveys; D006801:Humans; D008297:Male; D010655:Phenylenediamines / Q000276:immunology; D011159:Population Surveillance; D011634:Public Health; D012042:Registries; D012307:Risk Factors; D012967:Sodium Dodecyl Sulfate / Q000009:adverse effects; D013501:Surface-Active Agents / Q000009:adverse effects; D013557:Switzerland; D013893:Thiram / Q000276:immunology
chemical_list: D004396:Coloring Agents; D004853:Epoxy Resins; D005659:Fungicides, Industrial; D010655:Phenylenediamines; D013501:Surface-Active Agents; D013893:Thiram; D012967:Sodium Dodecyl Sulfate; C029728:4-phenylenediamine