title: Gender-specific spatio-temporal patterns of colorectal cancer incidence in Navarre, Spain (1990-2005).
abstract: BACKGROUND
  In the last ten to twenty years, a stabilization or decline in colorectal cancer (CRC) incidence has been observed in some countries across the world but not in Spain. Our objective here is to assess the gender-specific CRC spatio-temporal pattern in the health areas of Navarre, a Spanish province, during the period 1990-2005.
  
  
  METHODS
  For each gender, a model with spatio-temporal CAR (Conditional Autoregressive) distributions is used for smoothing the incidence risks. Smoothing is carried out in two dimensions: space and time, allowing for a different time evolution in each health area. An estimated incidence trend curve for each health area and the corresponding confidence bands are obtained. To analyze the evolution of the geographical patterns of CRC incidence risks, maps are also provided.
  
  
  RESULTS
  In both genders, CRC shows an increasing trend in most of the areas. In the second half of the period 1998-2005 most of the areas have risks above one although not all statistically significant. In general females present equal or lower risks than males in all areas during the studied period.
  
  
  CONCLUSIONS
  Colorectal cancer incidence risk is still increasing in the health areas of Navarre. Promoting healthful lifestyles for primary prevention and early detection programs could help to reverse the trend in the province.
authors.affiliation: Department of Statistics and O. R., Public University of Navarre, Campus de Arrosadía, Pamplona, Spain. lola@unavarra.es
authors.forename: M D
authors.initials: MD
authors.lastname: Ugarte
authors.forename: J
authors.initials: J
authors.lastname: Etxeberria
authors.forename: T
authors.initials: T
authors.lastname: Goicoa
authors.forename: E
authors.initials: E
authors.lastname: Ardanaz
mesh_terms: D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000453:epidemiology*; D055088:Early Detection of Cancer / Q000379:methods; D005260:Female; D006293:Health Promotion / Q000379:methods; D006801:Humans; D015994:Incidence; D008019:Life Style; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D012042:Registries; D012737:Sex Factors; D013030:Spain / Q000453:epidemiology; D013997:Time Factors