title: Is seladin-1 really a selective Alzheimer's disease indicator?
abstract: Selective Alzheimer's Disease Indicator-1 (Seladin-1) was originally identified by its down-regulation in the brains of Alzheimer's disease (AD) patients. Here, we re-examine existing data and present new gene expression data that refutes its role as a selective AD indicator. Furthermore, we caution against the use of the name "Seladin-1" and instead recommend adoption of the approved nomenclature, 3β-hydroxysterol Δ24-reductase (or DHCR24), which describes its catalytic function in cholesterol synthesis. Further work is required to determine what link, if any, exists between DHCR24 and AD.
authors.affiliation: School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW 2052, Australia.
authors.forename: Laura J
authors.initials: LJ
authors.lastname: Sharpe
authors.forename: Jenny
authors.initials: J
authors.lastname: Wong
authors.forename: Brett
authors.initials: B
authors.lastname: Garner
authors.forename: Glenda M
authors.initials: GM
authors.lastname: Halliday
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Brown
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D001921:Brain / Q000378:metabolism*; D015536:Down-Regulation; D006801:Humans; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D016874:Neurofibrillary Tangles / Q000473:pathology; D044925:Oxidoreductases Acting on CH-CH Group Donors / Q000378:metabolism*
chemical_list: D009419:Nerve Tissue Proteins; D044925:Oxidoreductases Acting on CH-CH Group Donors; C499055:DHCR24 protein, human