title: Recent progress in West Nile virus diagnosis and vaccination.
abstract: West Nile virus (WNV) is a positive-stranded RNA virus belonging to the Flaviviridae family, a large family with 3 main genera (flavivirus, hepacivirus and pestivirus). Among these viruses, there are several globally relevant human pathogens including the mosquito-borne dengue virus (DENV), yellow fever virus (YFV), Japanese encephalitis virus (JEV) and West Nile virus (WNV), as well as tick-borne viruses such as tick-borne encephalitis virus (TBEV). Since the mid-1990s, outbreaks of WN fever and encephalitis have occurred throughout the world and WNV is now endemic in Africa, Asia, Australia, the Middle East, Europe and the Unites States. This review describes the molecular virology, epidemiology, pathogenesis, and highlights recent progress regarding diagnosis and vaccination against WNV infections.
authors.affiliation: Laboratory of Gene Therapy, Faculty of Veterinary Sciences, Ghent University, Heidestraat 19, 9820 Merelbeke, Belgium. marina.defilette@UGent.be.
authors.forename: Marina
authors.initials: M
authors.lastname: De Filette
authors.forename: Sebastian
authors.initials: S
authors.lastname: Ulbert
authors.forename: Mike
authors.initials: M
authors.lastname: Diamond
authors.forename: Niek N
authors.initials: NN
authors.lastname: Sanders
mesh_terms: D000818:Animals; D001717:Birds; D006801:Humans; D008322:Mammals; D014611:Vaccination / Q000662:veterinary; D014765:Viral Vaccines / Q000276:immunology*; D014901:West Nile Fever / Q000175:diagnosis / Q000453:epidemiology / Q000662:veterinary / Q000821:virology; D014902:West Nile virus / Q000145:classification / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity
chemical_list: D014765:Viral Vaccines