title: [Level of selected antibacterial tear proteins in children with diabetes type 1].
abstract: OBJECTIVE
  Antibacterial immunity in diabetes is impaired, which increases the risk of general and local infections. The aim of the study was to evaluate non-specific local antibacterial immunity based on lactoferrin and lysozyme concentration in tears in children with diabetes type 1.
  
  
  METHODS
  Children at the age of 10-18 years old were studied. Group 1. consisted of children without diabetes, group 2. included patients with new onset of diabetes and group 3. consisted of children with decade-long diabetes. Among all patients tears were collected from inferior coniunctival fornix with hematocrit glass capillaries in purpose to measure lactoferrin and lysozyme concentration. ELISA method was used in laboratory testing.
  
  
  RESULTS
  Level of lactoferrin did not differ significantly among all groups. Concentration of lysozyme was statistically lower in group with decade-long diabetes (group 3.) compared to patients without diabetes. Mild correlation between lactoferrin and lysozyme levels was seen in individual patients in whole group of probands together.
  
  
  CONCLUSIONS
  Diabetes type 1 in children is associated with significant changes in concentration of tear proteins, which contribute to antibacterial immunity.
authors.affiliation: Z Kliniki Okulistyki Dzieciecej Katedry Pediatrii Zabiegowej Uniwersytetu Medycznego w Łodzi. agnieszkamoll@wp.pl
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Moll
authors.forename: Krystyna
authors.initials: K
authors.lastname: Wyka
authors.forename: Wojciech
authors.initials: W
authors.lastname: Młynarski
authors.forename: Anna
authors.initials: A
authors.lastname: Niwald
mesh_terms: D000293:Adolescent; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D003930:Diabetic Retinopathy / Q000276:immunology; D003941:Diagnostic Techniques, Ophthalmological; D004797:Enzyme-Linked Immunosorbent Assay; D005136:Eye Proteins / Q000032:analysis*; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D007781:Lactoferrin / Q000032:analysis*; D008297:Male; D009113:Muramidase / Q000032:analysis*
chemical_list: D005136:Eye Proteins; C042434:tear proteins; D009113:Muramidase; D007781:Lactoferrin