title: Association between Ser311Cys  polymorphism in the dopamine D2 receptor gene and schizophrenia risk: a  meta-analysis in Asian populations.
abstract: Numerous  studies have evaluated the association between Ser311Cys (rs1801028, C>G)  polymorphism of the dopamine D2 receptor (DRD2) gene and schizophrenia risk.  However, the specific association is still controversial. We examined whether  DRD2 Ser311Cys polymorphism confers schizophrenia risk in Asian populations.  Sixteen studies were retrieved reporting on a total of 2268 schizophrenia  patients and 2423 healthy controls. Meta-analysis of the results showed  significant associations between Ser311Cys polymorphism and schizophrenia risk  in the comparisons of G versus C (odds ratio (OR) = 1.47, 95% confidence  interval (CI) = 1.18-1.83, P = 0.0006) and CG+GG versus CC (OR = 1.45, 95%CI =  1.16- 1.82, P = 0.001). In a subgroup analysis by nationality, we found a  significant association between Ser311Cys polymorphism and schizophrenia risk  in the comparisons of G versus C and CG+GG versus CC genotype in the Japanese  population (OR = 1.75, 95%CI = 1.30-2.35, P = 0.0002; OR = 1.72, 95%CI =  1.27-2.33, P = 0.0004; respectively) but not in Chinese and Indian populations.  In conclusion, the G allele of DRD2 Ser311Cys polymorphism involves a potential  risk factor for schizophrenia in Asian populations, especially in the Japanese  population.
authors.affiliation: Department of Hospice, Shengjing Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
authors.forename: Z W
authors.initials: ZW
authors.lastname: Liu
authors.forename: J L
authors.initials: JL
authors.lastname: Liu
authors.forename: Y
authors.initials: Y
authors.lastname: An
authors.forename: L
authors.initials: L
authors.lastname: Zhang
authors.forename: Y M
authors.initials: YM
authors.lastname: Wang
mesh_terms: D001208:Asia; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D012307:Risk Factors; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D017448:Receptors, Dopamine D2