title: Impact of the CATIE trial on antipsychotic prescribing patterns at a state psychiatric facility.
abstract: BACKGROUND
  Results from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) indicate that, with the exception of olanzapine, no substantial overall differences were identified between second generation antipsychotics (SGAs) and the first generation antipsychotic (FGA) perphenazine.
  
  
  METHODS
  This study evaluated the effect of CATIE on antipsychotic prescribing. A retrospective review of 1807 adults with schizophrenia was conducted and relative quarterly percentages of FGA versus SGA prescriptions were calculated.
  
  
  RESULTS
  Time series analysis did not identify significant differences in rates of FGA prescriptions.
  
  
  CONCLUSIONS
  Critiques of the methods used in CATIE may have mitigated its potential impact on antipsychotic prescribing despite cost-effectiveness of perphenazine treatment.
authors.affiliation: The University of Texas at Austin, College of Pharmacy, 1 University Station-A1900, Austin, TX 78712, USA. amkorane@utmb.edu
authors.forename: Angela M
authors.initials: AM
authors.lastname: Koranek
authors.forename: Tawny L
authors.initials: TL
authors.lastname: Smith
authors.forename: Lisa M
authors.initials: LM
authors.lastname: Mican
authors.forename: Karen L
authors.initials: KL
authors.lastname: Rascati
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001569:Benzodiazepines / Q000627:therapeutic use; D011307:Drug Prescriptions / Q000706:statistics & numerical data*; D005260:Female; D006778:Hospitals, Psychiatric / Q000706:statistics & numerical data*; D006783:Hospitals, State / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077152:Olanzapine; D010546:Perphenazine / Q000627:therapeutic use; D012189:Retrospective Studies; D012559:Schizophrenia / Q000188:drug therapy*; D012737:Sex Factors; D013997:Time Factors
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines; D010546:Perphenazine; D000077152:Olanzapine