title: Severe vitamin D deficiency in a patient treated for hepatitis B with tenofovir.
abstract: With the increasing use of tenofovir disoproxil in the management of HIV and hepatitis B, serious adverse effects, such as renal dysfunction, will inevitably increase in frequency. We describe a case of a patient presenting with hypophosphataemia suggestive of Fanconi's syndrome, but in fact explicable by simple vitamin D deficiency. This emphasizes that while monitoring for adverse effects is recommended, physicians must consider all alternative causes for biochemical abnormalities prior to discontinuing tenofovir and delaying appropriate management.
authors.affiliation: Department of HIV Medicine, Chelsea and Westminster Hospital, London, UK.
authors.forename: N
authors.initials: N
authors.lastname: Kumar
authors.forename: M
authors.initials: M
authors.lastname: Bower
authors.forename: M
authors.initials: M
authors.lastname: Nelson
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006509:Hepatitis B / Q000097:blood / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D017674:Hypophosphatemia / Q000209:etiology; D008297:Male; D008875:Middle Aged; D063065:Organophosphonates / Q000627:therapeutic use*; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use*; D000068698:Tenofovir; D014808:Vitamin D Deficiency / Q000150:complications* / Q000188:drug therapy
chemical_list: D063065:Organophosphonates; D018894:Reverse Transcriptase Inhibitors; D000068698:Tenofovir; D000225:Adenine