title: [Functioning of the antioxidant system in epithelial cells of small intestine under the influence of ionizing radiation of low dose rate].
abstract: The investigations of the functional state of the antioxidant system in epithelial cells from rat small intestine in dynamics after X-ray irradiation (0.1; 0.5 and 1.0 Gy) at a low absorbed dose rate (55 mGy/min) were performed. The obtained results point out the ambiguity of the antioxidant system reaction to the activation of oxidative processes at different doses of irradiation. The multidirectional changes of these antioxidant enzymatic activities whose functioning is characterized by the early post-irradiation recovery depending on the value of the absorbed dose were observed. The sensitivity of superoxide dismutase, glutathione transferase and glutathione peroxidase in mitochondria of epithelial cells to the irradiation exposure in the investigated range of absorbed doses was shown.
authors.forename: S V
authors.initials: SV
authors.lastname: Khizhniak
authors.forename: A A
authors.initials: AA
authors.lastname: Prokhorova
authors.forename: L I
authors.initials: LI
authors.lastname: Stepanova
authors.forename: V M
authors.initials: VM
authors.lastname: Voĭtsitskiĭ
mesh_terms: D000818:Animals; D002374:Catalase / Q000032:analysis / Q000378:metabolism*; D004307:Dose-Response Relationship, Radiation; D005979:Glutathione Peroxidase / Q000032:analysis / Q000378:metabolism*; D005982:Glutathione Transferase / Q000032:analysis / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000201:enzymology / Q000528:radiation effects*; D007421:Intestine, Small / Q000166:cytology / Q000528:radiation effects*; D008297:Male; D008928:Mitochondria / Q000528:radiation effects; D011839:Radiation, Ionizing; D051381:Rats; D013482:Superoxide Dismutase / Q000032:analysis / Q000378:metabolism*; D014916:Whole-Body Irradiation
chemical_list: D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005982:Glutathione Transferase