title: The efficacy of topical interferon alpha 2b treatment in refractory vernal keratoconjunctivitis.
abstract: OBJECTIVE
  This study aimed to investigate the efficacy and safety of a 2-month topical interferon alpha 2b treatment in patients with refractory vernal keratoconjunctivitis.
  
  
  METHODS
  Twelve (10 male, 2 female) patients with refractory vernal keratoconjunctivitis received topical treatment with one million IU/mL interferon alpha 2b 4 times a day for 2 months. Symptom and ophthalmological examination scores were assessed at baseline and during follow-up.
  
  
  RESULTS
  No significant complications or side effects associated with the use of topical interferon alpha 2b were observed. Symptom scores for itching, tearing, photophobia, and total symptom score, and objective scores for corneal lesion, hyperemia, chemosis, papillary hypertrophy, secretion, and total examination score significantly improved during the 2-month treatment. Improvements were maintained after discontinuation of the treatment for most parameters.
  
  
  CONCLUSIONS
  Topical interferon alpha 2b treatment seems to offer a safe and effective alternative for the treatment of refractory vernal keratoconjunctivitis for a brief period.
authors.affiliation: Haydarpasa Numune Education and Research Hospital, Ophthalmology Clinic, Istanbul, Turkey. dreceturan76@yahoo.com
authors.forename: Ece
authors.initials: E
authors.lastname: Turan-Vural
authors.forename: Banu Torun
authors.initials: BT
authors.lastname: Acar
authors.forename: Suphi
authors.initials: S
authors.lastname: Acar
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003233:Conjunctivitis, Allergic / Q000188:drug therapy*; D005260:Female; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D008297:Male; D009883:Ophthalmic Solutions / Q000627:therapeutic use*; D011994:Recombinant Proteins / Q000627:therapeutic use; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D009883:Ophthalmic Solutions; D011994:Recombinant Proteins