title: Cultivation practices and manufacturing processes to produce Hoodia gordonii extract for weight management products.
abstract: Hoodia gordonii (Masson) Sweet ex Decne., is a succulent shrub, indigenous to the arid regions of southern Africa. Indigenous people have historically utilised certain species of Hoodia, including H. gordonii, as a source of food and water. Studies by the Council for Scientific and Industrial Research (CSIR, South Africa) identified that extracts of H. gordonii had appetite suppressant activity associated with specific steroid glycosides. A programme to develop weight management products based around this discovery was implemented in 1998. An agronomy programme was established which demonstrated that it was possible to cultivate this novel crop on a commercial scale (in excess of 70 ha). In parallel, a food grade manufacturing process was developed consisting of four main steps: harvesting of H. gordonii plant stems, comminution, drying under controlled conditions and extraction using food grade solvents. Appropriate Quality Control (QC) procedures were developed. The extraction process is capable of delivering a consistent composition despite natural variations in the composition of the dried H. gordonii. Specifications were developed for the resulting extract. The intended use of the standardised H. gordonii extract was as a functional food ingredient for weight management products. Other development studies on characterisation, toxicology and pharmacology are reported separately.
authors.affiliation: Phytopharm plc, Lakeview House, 2 Lakeview Court, Ermine Business Park, Huntingdon, Cambridgeshire, PE29 6UA, UK.
authors.forename: Tamsin L
authors.initials: TL
authors.lastname: Knight
authors.forename: Chris M
authors.initials: CM
authors.lastname: Swindells
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Craddock
authors.forename: Vinesh J
authors.initials: VJ
authors.lastname: Maharaj
authors.forename: Sybille
authors.initials: S
authors.lastname: Buchwald-Werner
authors.forename: Smail Alaoui
authors.initials: SA
authors.lastname: Ismaili
authors.forename: Simon C
authors.initials: SC
authors.lastname: McWilliam
mesh_terms: D029062:Apocynaceae / Q000737:chemistry* / Q000254:growth & development*; D001067:Appetite Depressants / Q000138:chemical synthesis*; D019587:Dietary Supplements; D006801:Humans; D008420:Manufactured Materials; D016488:Medicine, African Traditional; D008517:Phytotherapy / Q000379:methods*; D010936:Plant Extracts / Q000032:analysis*
chemical_list: D001067:Appetite Depressants; D010936:Plant Extracts