title: Persistent pulmonary hypertension of the newborn and selective serotonin reuptake inhibitors: lessons from clinical and translational studies.
abstract: Two recent studies linking in utero exposure to selective serotonin reuptake inhibitors (SSRIs) with persistent pulmonary hypertension of the newborn (PPHN), a potentially serious but rare respiratory illness, have made clinicians and patients more reluctant to use SSRIs during pregnancy. However, additional clinical studies have associated maternal depression rather than SSRI exposure as a risk factor for PPHN. This review summarizes the current knowledge regarding PPHN pathophysiology, including the role of serotonin and genetic risk factors; the effects of SSRIs on pulmonary vasculature; the possible link between SSRIs and PPHN; and the diagnosis, clinical management, and prognosis of PPHN.
authors.affiliation: Department of Psychiatry at Weill Cornell Medical College in New York, USA. mbc2003@med.cornell.edu
authors.forename: Mallay
authors.initials: M
authors.lastname: Occhiogrosso
authors.forename: Setareh Salehi
authors.initials: SS
authors.lastname: Omran
authors.forename: Margaret
authors.initials: M
authors.lastname: Altemus
mesh_terms: D000928:Antidepressive Agents / Q000008:administration & dosage / Q000009:adverse effects; D002986:Clinical Trials as Topic; D015331:Cohort Studies; D003866:Depressive Disorder / Q000150:complications / Q000503:physiopathology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange; D033261:Maternal-Fetal Relations; D010547:Persistent Fetal Circulation Syndrome / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology; D011247:Pregnancy; D037841:Pregnant People / Q000523:psychology*; D011297:Prenatal Exposure Delayed Effects / Q000209:etiology*; D012307:Risk Factors; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D057170:Translational Research, Biomedical
chemical_list: D000928:Antidepressive Agents; D050486:Serotonin Plasma Membrane Transport Proteins; D017367:Selective Serotonin Reuptake Inhibitors