title: Vitamin d status and indices of bone turnover in older European adults.
abstract: An increased rate of bone turnover increases risk of osteoporotic fracture later in life. The concentration of 25-hydroxyvitamin D that contributes to an elevated rate of bone turnover in older adults is unclear. The objective of this study was to investigate the associations between 25-hydroxyvitamin D and biochemical markers of bone turnover in an older, pan-European cohort. 25-hydroxyvitamin D and serum markers of bone-formation (osteocalcin and bone-specific alkaline phosphatase) were assessed by ELISA, while urinary markers of bone-resorption (pyridinoline and deoxypyridinoline) were assessed by HPLC. Six percent, 36 %, and 64 % of subjects had 25-hydroxyvitamin D concentrations < 25, < 50, and < 80 nmol/L throughout the year, respectively. 25-hydroxyvitamin D was significantly and inversely correlated with serum bone-specific alkaline phosphatase (r = 0.119; p = 0.022) and urinary pyridinoline (r = 0.207; p < 0.0001) and deoxypyridinoline (r = 0.230; p < 0.0001). Stratification on the basis of tertiles [T] of 25-hydroxyvitamin D (< 47.6 [T(1)]; 47.6 - 85.8 [T₂]; > 85.8 [T₃] nmol/L), showed that urinary pyridinoline and deoxypyridinoline were significantly lower in subjects in the 2(nd) and 3(rd) compared to the 1(st) tertile (p < 0.015). Low vitamin D status (< 50 nmol/L) was associated with an increased rate of bone turnover in this older pan-European cohort.
authors.affiliation: School of Food and Nutritional Sciences, University College Cork, Ireland.
authors.forename: Kelly M
authors.initials: KM
authors.lastname: Seamans
authors.forename: Tom R
authors.initials: TR
authors.lastname: Hill
authors.forename: Lisa
authors.initials: L
authors.lastname: Scully
authors.forename: Nathalie
authors.initials: N
authors.lastname: Meunier
authors.forename: Maude
authors.initials: M
authors.lastname: Andrillo-Sanchez
authors.forename: Angela
authors.initials: A
authors.lastname: Polito
authors.forename: Isabelle
authors.initials: I
authors.lastname: Hininger-Favier
authors.forename: Donatella
authors.initials: D
authors.lastname: Ciarapica
authors.forename: Elizabeth E A
authors.initials: EE
authors.lastname: Simpson
authors.forename: Barbara J
authors.initials: BJ
authors.lastname: Stewart-Knox
authors.forename: Jacqueline M
authors.initials: JM
authors.lastname: O Connor
authors.forename: Charles
authors.initials: C
authors.lastname: Coudray
authors.forename: Kevin D
authors.initials: KD
authors.lastname: Cashman
mesh_terms: D000368:Aged; D000375:Aging / Q000502:physiology*; D000469:Alkaline Phosphatase / Q000097:blood; D000596:Amino Acids / Q000652:urine; D015415:Biomarkers / Q000032:analysis*; D016723:Bone Remodeling / Q000502:physiology*; D003430:Cross-Sectional Studies; D005060:Europe; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood; D014807:Vitamin D / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000150:complications
chemical_list: D000596:Amino Acids; D015415:Biomarkers; D015675:Osteocalcin; D014807:Vitamin D; C015484:pyridinoline; C036020:deoxypyridinoline; C104450:25-hydroxyvitamin D; D000469:Alkaline Phosphatase