title: Comparison of two formulations of buprenorphine in cats administered by the oral transmucosal route.
abstract: This randomised, blinded, cross-over study investigated the ease of oral transmucosal administration of two formulations of buprenorphine using glucose as a control in 12 cats. The cats received three treatments: buprenorphine multi-dose, buprenorphine and the equivalent volume of glucose 5%. Ease of treatment administration, observation of swallowing, changes in pupil size, sedation, salivation, vomiting, behaviour and food intake were assessed. The data were analysed using MLwiN and multi-level modelling. Ease of administration of buprenorphine multi-dose was statistically different from glucose (P <0.001), and the administration of all treatments became easier over the study periods. Swallowing was not statistically different between groups (P >0.05). Mydriasis was evident after the administration of both formulations of buprenorphine. Sedation, salivation, vomiting, behavioural changes or in-appetence were not observed after any treatment. Cats tolerated oral transmucosal administration of glucose better than buprenorphine multi-dose, while buprenorphine administration was tolerated as well as glucose.
authors.affiliation: University of Bristol, School of Veterinary Sciences, Bristol UK. Elisa.Bortolami@bristol.ac.uk
authors.forename: Elisa
authors.initials: E
authors.lastname: Bortolami
authors.forename: Louisa
authors.initials: L
authors.lastname: Slingsby
authors.forename: Emma J
authors.initials: EJ
authors.lastname: Love
mesh_terms: D000278:Administration, Buccal; D000701:Analgesics, Opioid / Q000008:administration & dosage* / Q000737:chemistry* / Q000493:pharmacokinetics; D000818:Animals; D002047:Buprenorphine / Q000008:administration & dosage* / Q000737:chemistry* / Q000493:pharmacokinetics; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats / Q000601:surgery; D002626:Chemistry, Pharmaceutical; D018592:Cross-Over Studies; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005947:Glucose / Q000008:administration & dosage; D006439:Hemodynamics / Q000187:drug effects*; D007408:Intestinal Absorption
chemical_list: D000701:Analgesics, Opioid; D002047:Buprenorphine; D005947:Glucose