title: Structure-activity studies of some berberine analogs as inhibitors of Toxoplasma gondii.
abstract: The shortfalls of the current treatment options against infections with the parasite Toxoplasma gondii (T. gondii) necessitates the development of non-toxic and well-tolerated alternatives. To address this problem a structurally diverse panel of berberine alkaloids was synthesized and evaluated for in vitro inhibition of T. gondii tachyzoites. Inhibitory doses (ID(50)) of less than 50 nM and therapeutic indices (TI) up to 4000 were observed.
authors.affiliation: Department of Chemistry & Biochemistry, University of Minnesota Duluth, Duluth, MN 55812, United States.
authors.forename: Bogdana
authors.initials: B
authors.lastname: Krivogorsky
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Pernat
authors.forename: Kelsi A
authors.initials: KA
authors.lastname: Douglas
authors.forename: Nikolas J
authors.initials: NJ
authors.lastname: Czerniecki
authors.forename: Peter
authors.initials: P
authors.lastname: Grundt
mesh_terms: D000977:Antiparasitic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001599:Berberine / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002478:Cells, Cultured; D020128:Inhibitory Concentration 50; D014122:Toxoplasma / Q000187:drug effects*
chemical_list: D000977:Antiparasitic Agents; D001599:Berberine