title: Safety assessment of a new multivitamin.
abstract: A newly created multivitamin possesses many protective health functions. To investigate its safety when applied in medical treatment and when used as a food supplement, we studied its acute oral toxicity and 13-week oral toxicity in mice. The results showed that the oral lethal dose, 50% (LD(50)) of the biomass of the multivitamin in mice was greater than 2492 mg/kg body weight (BW) and that poisoned mice recovered within 72 h. The no observed effect level (NOEL) of long-term consumption was more than 249.3mg/kg BW for haematological parameters, clinical chemistry parameters, histopathological examination of organs, food consumption, BW, ratio of organ weight to BW and other physiological parameters and conditions. Therefore, we conclude that dosages of up to 249.3 mg/kg BW/day of this multivitamin do not cause chronic toxicity in animals. Administration of this multivitamin may even improve the resistance of animals to negative environmental factors and may be safe for long-term consumption to enhance the health of individuals in accordance with the prescribed dosage (1.4 ∼ 4.2 mg/kg BW/day).
authors.affiliation: School of Chemistry and Bioengineering, Changsha University of Science and Technology, Changsha 410004, China. taojun1954@126.com
authors.forename: Jun
authors.initials: J
authors.lastname: Tao
authors.forename: Hai-wen
authors.initials: HW
authors.lastname: Kong
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Yun-hui
authors.initials: YH
authors.lastname: Cheng
authors.forename: Xiao-shun
authors.initials: XS
authors.lastname: Shu
authors.forename: Bi-jun
authors.initials: BJ
authors.lastname: Tan
authors.forename: Xue-feng
authors.initials: XF
authors.lastname: Yang
mesh_terms: D000284:Administration, Oral; D000818:Animals; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D019055:No-Observed-Adverse-Effect Level; D023382:Toxicity Tests, Acute; D014815:Vitamins / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D014815:Vitamins