title: The molecular basis of Notch signaling: a brief overview.
abstract: The Notch signaling pathway is evolutionarily conserved and has been associated with numerous developmental processes, including stem cell maintenance and adult tissue homeostasis. Notably, both abnormal increases and deficiencies of Notch signaling result in human developmental anomalies and cancer development implying that the precise regulation of the intensity and duration of Notch signals is imperative. Numerous studies have demonstrated that the aberrant gain or loss of Notch signaling pathway components is critically linked to multiple human diseases. In this chapter, we will briefly summarize the molecular basis of Notch signaling, focusing on the modulation of Notch signals, and its developmental outcomes including vessel formation and the onset of cancer.
authors.affiliation: Department of Physiology, Pusan National University, Pusan, Korea.
authors.forename: Sang-Mo
authors.initials: SM
authors.lastname: Kwon
authors.forename: Cantas
authors.initials: C
authors.lastname: Alev
authors.forename: Sang-Hun
authors.initials: SH
authors.lastname: Lee
authors.forename: Takayuki
authors.initials: T
authors.lastname: Asahara
mesh_terms: D000328:Adult; D002450:Cell Communication; D002454:Cell Differentiation; D006706:Homeostasis; D006801:Humans; D051880:Receptors, Notch / Q000502:physiology*; D015398:Signal Transduction
chemical_list: D051880:Receptors, Notch