title: Human papillomavirus vaccine and pregnancy.
abstract: QUESTION A: patient of mine who recently learned she was 6 weeks pregnant had received the recombinant human papillomavirus (HPV) quadrivalent vaccine at 4 weeks of gestation. She is quite worried about how this will affect her baby. What is known about the safety of the HPV vaccine during pregnancy?
  
  
  CONCLUSIONS
  The HPV vaccine is generally not recommended for use in pregnant women. However, theoretically, because it is not a live vaccine, it is not expected to be associated with an increased risk. Also, information from the manufacturer's pregnancy registry and phase 3 clinical trials does not indicate an increased risk of fetal malformations or other adverse effects due to the vaccine.
authors.affiliation: University of Toronto, Ontario.
authors.forename: Andrea
authors.initials: A
authors.lastname: Narducci
authors.forename: Adrienne
authors.initials: A
authors.lastname: Einarson
authors.forename: Pina
authors.initials: P
authors.lastname: Bozzo
mesh_terms: D005260:Female; D000068857:Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18; D006801:Humans; D053918:Papillomavirus Vaccines / Q000009:adverse effects*; D011247:Pregnancy; D011256:Pregnancy Outcome; D015164:Vaccines, Inactivated / Q000009:adverse effects*
chemical_list: D000068857:Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18; D053918:Papillomavirus Vaccines; D015164:Vaccines, Inactivated