title: A chromosome 19 locus positively influences the number of retrieved oocytes during stimulated cycles in Brazilian women.
abstract: OBJECTIVE
  To evaluate if several genetic loci that are associated with variation in normal menopause age and early menopause can account for a poor response to controlled ovarian stimulation.
  
  
  METHODS
  A total of 71 patients age ≤35 years old who were undergoing intracytoplasmic sperm injection were genotyped for four genetic variants that are associated with normal variation in menopausal age and early menopause. The patients were divided into two groups based upon treatment response: a poor responder group (PR group, n = 21) and a normal responder group (NR group, n = 50). The genetic variants rs244715, rs9379896, rs4806660 and rs16991615 were analyzed.
  
  
  RESULTS
  There was no significant difference in the incidence of the genetic variants between the NR and PR group. The risk allele for the chromosome 19 variant (rs4806660) demonstrated a protective effect for a poor ovarian response. The presence of a risk allele was associated with an increased response to COS, which resulted in an elevated number of follicles (Coef: 2.54, P = 0.041) and retrieved oocytes (Coef: 1.41, P = 0.041).
  
  
  CONCLUSIONS
  The genetic variants rs244715, rs9379896, rs4806660 and rs16991615 are not risk factors for poor ovarian response in Brazilian women. In contrast, rs4806660 is associated with higher number of follicles and retrieved oocytes. rs4806660 may be associated with an increased response to gonadotrophin stimulation in this population.
authors.affiliation: Sapientiae Institute-Educational and Research Centre in Assisted Reproduction, Rua Vieira Maciel, 62, São Paulo, SP, Brazil, Zip: 04203-040.
authors.forename: Amanda Souza
authors.initials: AS
authors.lastname: Setti
authors.forename: Sylvia Sanches
authors.initials: SS
authors.lastname: Cortezzi
authors.forename: Rita de Cássia S
authors.initials: Rde C
authors.lastname: Figueira
authors.forename: Ciro Dresch
authors.initials: CD
authors.lastname: Martinhago
authors.forename: Daniela Paes de Almeida Ferreira
authors.initials: DP
authors.lastname: Braga
authors.forename: Assumpto
authors.initials: A
authors.lastname: Iaconelli
authors.forename: Edson
authors.initials: E
authors.lastname: Borges
mesh_terms: D000328:Adult; D000483:Alleles; D002888:Chromosomes, Human, Pair 19; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008593:Menopause / Q000235:genetics*; D009865:Oocytes / Q000502:physiology*; D006080:Ovarian Follicle / Q000502:physiology; D010062:Ovulation Induction / Q000379:methods; D020554:Sperm Injections, Intracytoplasmic / Q000379:methods