title: HIV-1 prevention for HIV-1 serodiscordant couples.
abstract: A substantial proportion of HIV-1 infected individuals in sub-Saharan Africa are in stable relationships with HIV-1 uninfected partners, and HIV-1 serodiscordant couples thus represent an important target population for HIV-1 prevention. Couple-based HIV-1 testing and counseling facilitates identification of HIV-1 serodiscordant couples, counseling about risk reduction, and referrals to HIV-1 treatment, reproductive health services, and support services. Maximizing HIV-1 prevention for HIV-1 serodiscordant couples requires a combination of strategies, including counseling about condoms, sexual risk, fertility, contraception, and the clinical and prevention benefits of antiretroviral therapy (ART) for the HIV-1-infected partner; provision of clinical care and ART for the HIV-1-infected partner; antenatal care and services to prevent mother-to-child transmission for HIV-1-infected pregnant women; male circumcision for HIV-1-uninfected men; and, pending guidelines and demonstration projects, oral pre-exposure prophylaxis (PrEP) for HIV-1-uninfected partners.
authors.affiliation: International Clinical Research Center, Department of Global Health, University of Washington, Seattle, WA 98104, USA. kgcurran@uw.edu
authors.forename: Kathryn
authors.initials: K
authors.lastname: Curran
authors.forename: Jared M
authors.initials: JM
authors.lastname: Baeten
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Coates
authors.forename: Ann
authors.initials: A
authors.lastname: Kurth
authors.forename: Nelly R
authors.initials: NR
authors.lastname: Mugo
authors.forename: Connie
authors.initials: C
authors.lastname: Celum
mesh_terms: D000349:Africa; D044966:Anti-Retroviral Agents / Q000627:therapeutic use*; D005193:Family Planning Services; D005260:Female; D015658:HIV Infections / Q000517:prevention & control* / Q000635:transmission; D018023:HIV Seronegativity; D006679:HIV Seropositivity; D015497:HIV-1; D020010:Heterosexuality; D006801:Humans; D008297:Male; D011314:Preventive Health Services / Q000379:methods; D012307:Risk Factors; D012725:Sexual Behavior; D012747:Sexual Partners
chemical_list: D044966:Anti-Retroviral Agents