title: Reversible ON/OFF nanoswitch for organocatalysis: mimicking the locking and unlocking operation of CaMKII.
abstract: Flip a switch: a nanoswitch uses chemical inputs to turn an organocatalytic Knoevenagel reaction on and off (see scheme: R=reactant, P=product). To stop catalysis the chemical input (pink and green) wraps around the inhibitory segment of the nanoswitch to effect release or unlocking of the switch. The process can run reversibly over three cycles without loss of activity.
authors.affiliation: Center of Micro and Nanochemistry and Engineering, Organische Chemie I, Universität Siegen, Germany. schmittel@chemie.uni-siegen.de
authors.forename: Michael
authors.initials: M
authors.lastname: Schmittel
authors.forename: Soumen
authors.initials: S
authors.lastname: De
authors.forename: Susnata
authors.initials: S
authors.lastname: Pramanik