title: Diagnosis and management of hydatid liver disease in children: a report of 156 patients with hydatid disease.
abstract: OBJECTIVE
  There are many published reviews on adult hydatid disease and a guideline published by World Health Organization Informal Working Group (WHO-IWGE) in 2010. However, there are very few reports on hydatid liver disease in children with limited numbers of patients, and no comments were offered on childhood hydatid liver disease in the WHO-IWGE 2010 guideline. The aim of this study is to present our 17-year experience with 156 pediatric patients with hydatid liver disease and provide a treatment algorithm for children.
  
  
  METHODS
  The clinical records of 156 children with hydatid liver disease treated from January 1994 to January 2011 were retrospectively reviewed. Patient sex, age at diagnosis, symptoms, disease location, cyst numbers and sizes, treatment choices, medical treatment duration, surgical methods, and complications were recorded. Treatment of liver hydatidosis included 3 different schedules: (1) small (<5 cm) liver cysts treated with albendazole (ABZ) only, (2) cysts (>5 cm) located at the liver surface treated with surgery combined with ABZ, and (3) all (>5 cm) liver cysts embedded deep in the liver parenchyme treated with percutaneous drainage and ABZ. Albendazole was given (10 mg/kg twice a day) and continued for 6 months after initial therapy.
  
  
  RESULTS
  There were 92 boys and 64 girls with an average age of 9.2 years (range, 1.1-15 years). A total of 376 cysts were detected in 156 patients. The follow-up period ranged from 1 to 10 years (median, 6.5 years). Complications were classified according to the Dindo classification. After the first 6 months of therapy, grade I complications occurred in 12.1% of patients, grade II complications in 7.4%, and grade IIIb complications in 7.3%. There were no grade IIIa, IVa, or IVb complications. At 1 year, grade II complications were recorded in 9.6% of 15 patients, and grade IIIb complications, in 1.2% of patients. During the 17 years reviewed, there were no mortalities (0% grade V complications).
  
  
  CONCLUSIONS
  Based on this experience, we believe that suitable treatment should be chosen based on factors such as cyst number, cyst location (on the surface or deep in the organ), proximity to vascular structures, whether the cyst is complicated, and additional organ involvement or not. In addition, although the results of our study mostly agree with the results in the WHO-IWGE 2010 report, there are some noticeable differences between these 2 studies. Hence, we believe that the WHO-IWGE 2010 recommendations should be updated by incorporating the childhood observations.
authors.affiliation: Department of Pediatric Surgery, Faculty of Medicine, Atatürk University, Erzurum, Turkey. ak_oral@hotmail.com
authors.forename: Akgun
authors.initials: A
authors.lastname: Oral
authors.forename: Murat
authors.initials: M
authors.lastname: Yigiter
authors.forename: Abdullah
authors.initials: A
authors.lastname: Yildiz
authors.forename: Onur
authors.initials: O
authors.lastname: Yalcin
authors.forename: Tuba
authors.initials: T
authors.lastname: Dikmen
authors.forename: Suat
authors.initials: S
authors.lastname: Eren
authors.forename: Mecit
authors.initials: M
authors.lastname: Kantarci
authors.forename: Ahmet Bedii
authors.initials: AB
authors.lastname: Salman
mesh_terms: D000293:Adolescent; D015766:Albendazole / Q000627:therapeutic use; D000465:Algorithms; D000871:Anthelmintics / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D003661:Decision Support Techniques; D004322:Drainage / Q000379:methods; D004334:Drug Administration Schedule; D004444:Echinococcosis, Hepatic / Q000150:complications / Q000175:diagnosis / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D012189:Retrospective Studies
chemical_list: D000871:Anthelmintics; D015766:Albendazole