title: Relevance of the lectin pathway of complement in rheumatic diseases.
abstract: Due to its importance both in the clearance of pathogens that contribute as rheumatic etiological agents and in the disposal of apoptotic bodies and potential autoimmune initiators, deficiencies of the components of the lectin pathway of complement have been found to increase susceptibility and modulate the severity of most rheumatic disorders. This chapter introduces the general aspects of the structure, function, and genetics of lectin pathway components and summarizes current knowledge of the field regarding rheumatic diseases predisposition and modulation.
authors.affiliation: Molecular Immunopathology Laboratory, Department of Medical Pathology, Federal University of Paraná, Curitiba, Brazil.
authors.forename: Angelica B W
authors.initials: AB
authors.lastname: Boldt
authors.forename: Isabela
authors.initials: I
authors.lastname: Goeldner
authors.forename: Iara J T
authors.initials: IJ
authors.lastname: de Messias-Reason
mesh_terms: D001172:Arthritis, Rheumatoid / Q000276:immunology / Q000378:metabolism* / Q000503:physiopathology; D037582:Complement Pathway, Mannose-Binding Lectin / Q000276:immunology*; D003165:Complement System Proteins / Q000276:immunology / Q000378:metabolism; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology / Q000378:metabolism* / Q000503:physiopathology; D037241:Mannose-Binding Lectins / Q000737:chemistry / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D011110:Polymorphism, Genetic; D012213:Rheumatic Fever / Q000276:immunology / Q000378:metabolism* / Q000503:physiopathology; D012859:Sjogren's Syndrome / Q000276:immunology / Q000378:metabolism* / Q000503:physiopathology
chemical_list: D037241:Mannose-Binding Lectins; D003165:Complement System Proteins