title: Abnormal recovery function of somatosensory evoked potentials in patients with primary insomnia.
abstract: Neurobiological correlates underlying insomnia are poorly understood. The hyperarousal of the central nervous system indicates that cortical excitability may be abnormal in patients with insomnia. The purpose of the present study was to investigate changes in cortical excitability by examining the recovery function of median nerve somatosensory evoked potentials (SEPs) in patients with primary insomia (PI). We studied the recovery function of median nerve SEPs in 12 medication-naive PI patients and in 12 age- and sex-matched healthy subjects. SEPs in response to single stimulus and paired stimuli at interstimulus intervals (ISIs) of 20, 60, 100 and 150 ms were recorded. The recovery function of the cortical components of frontal P20 and parietal N20 showed significantly reduced suppression in PI patients as compared to healthy controls. In conclusion, this is the first study investigating changes in cortical excitability in PI patients by examining the recovery function of median nerve SEPs. The present study suggests that cortical excitability is increased in PI patients. Dysfunction of inhibitory GABAergic interneurons of the cerebral cortex might contribute to the increased cortical excitability in PI patients.
authors.affiliation: Department of Neurology, Xuanwu Hospital, Capital Medical University, No. 45 Changchunjie Road, Beijing 100053, China.
authors.forename: Zhaoyang
authors.initials: Z
authors.lastname: Huang
authors.forename: Shuqin
authors.initials: S
authors.lastname: Zhan
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.forename: Yan
authors.initials: Y
authors.lastname: Ding
authors.forename: Yuping
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004558:Electric Stimulation / Q000379:methods; D005073:Evoked Potentials, Somatosensory / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008475:Median Nerve / Q000502:physiology; D020127:Recovery of Function / Q000502:physiology*; D007319:Sleep Initiation and Maintenance Disorders / Q000503:physiopathology*; D013003:Somatosensory Cortex / Q000503:physiopathology*