title: An unusual manifestation of post-transplant lymphoproliferative disorder in the lip after pediatric heart transplantation.
abstract: PTLD is a serious and frequently observed complication after solid organ transplantation. We present a six-yr-old girl with a rapidly growing, solid tumor of the lip four yr after orthotopic heart transplantation, which was classified as monomorphic PTLD with the characteristics of a diffuse large B-cell lymphoma. Treatment with reduction in immunosuppression, ganciclovir, and anti B-cell monoclonal antibody (rituximab) resulted in full remission since 12 months. To the best of our knowledge, this report is the first description of PTLD in the lip in a pediatric patient after heart transplantation in the English literature.
authors.affiliation: Department of Pediatric Cardiology and Pneumology, University Düsseldorf, Düsseldorf, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Chen
authors.forename: S
authors.initials: S
authors.lastname: Akanay-Diesel
authors.forename: F R
authors.initials: FR
authors.lastname: Schuster
authors.forename: D
authors.initials: D
authors.lastname: Klee
authors.forename: K G
authors.initials: KG
authors.lastname: Schmidt
authors.forename: B C
authors.initials: BC
authors.lastname: Donner
mesh_terms: D058846:Antibodies, Monoclonal, Murine-Derived / Q000494:pharmacology; D009202:Cardiomyopathies / Q000150:complications / Q000628:therapy*; D002648:Child; D020031:Epstein-Barr Virus Infections / Q000150:complications / Q000175:diagnosis; D005260:Female; D015774:Ganciclovir / Q000494:pharmacology; D006333:Heart Failure / Q000150:complications / Q000628:therapy*; D016027:Heart Transplantation / Q000009:adverse effects*; D004854:Herpesvirus 4, Human / Q000378:metabolism; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology; D008046:Lip / Q000276:immunology*; D008048:Lip Neoplasms / Q000209:etiology* / Q000628:therapy; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000628:therapy; D008232:Lymphoproliferative Disorders / Q000150:complications / Q000175:diagnosis*; D011183:Postoperative Complications; D012074:Remission Induction; D000069283:Rituximab; D013997:Time Factors
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D007166:Immunosuppressive Agents; D000069283:Rituximab; D015774:Ganciclovir