title: Biomimetic total synthesis of cruentaren A via aromatization of diketodioxinones.
abstract: The total synthesis of cruentaren A, a biologically active resorcylate natural product, is reported. The aromatic unit was constructed via late-stage cyclization and aromatization from a diketodioxinone intermediate and macrocyclization using Fürstner ring-closing alkyne metathesis.
authors.affiliation: Department of Chemistry, Imperial College, London SW7 2AZ, England.
authors.forename: Marianne
authors.initials: M
authors.lastname: Fouché
authors.forename: Lisa
authors.initials: L
authors.lastname: Rooney
authors.forename: Anthony G M
authors.initials: AG
authors.lastname: Barrett
mesh_terms: D032701:Biomimetics; D003500:Cyclization; D007659:Ketones / Q000737:chemistry*; D018942:Macrolides / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D007659:Ketones; D018942:Macrolides; C516694:cruentaren A