title: IL-36 in psoriasis.
abstract: Psoriasis is a common but severe skin disease with significant health consequences, both physical and psychological. Evidence has emerged during the past several years pointing to a key role for IL-36 in psoriasis. Overexpression of IL-36 in mouse skin leads to a disease quite similar to human plaque psoriasis, and inhibition of IL-36 in human psoriatic skin ameliorates the inflammation. Loss of the natural antagonist of IL-36, IL-36Ra, results in a different, more severe skin disease known as pustular psoriasis. These effects are likely a consequence of the actions of IL-36 both on cells of the immune system as well as on components of skin including fibroblasts and keratinocytes.
authors.affiliation: Inflammation Research, Amgen Inc., Seattle, WA 98119, United States.
authors.forename: J E
authors.initials: JE
authors.lastname: Towne
authors.forename: J E
authors.initials: JE
authors.lastname: Sims
mesh_terms: D000818:Animals; D006801:Humans; D007375:Interleukin-1 / Q000276:immunology*; D011565:Psoriasis / Q000276:immunology*; D012137:Respiratory System / Q000276:immunology; D012867:Skin / Q000276:immunology
chemical_list: D007375:Interleukin-1; C572887:interleukin 36, human