title: Lean body mass, physical activity and quality of life in paediatric patients with inflammatory bowel disease and in healthy controls.
abstract: OBJECTIVE
  Physical activity is important for muscle and bone strength in the growing child and may be impaired in paediatric patients with inflammatory bowel disease (IBD) even during quiescent disease. The SenseWearPro(2) armband allows to measure physical activity under everyday life conditions.
  
  
  METHODS
  Thirty-nine IBD patients (27 Crohn's disease, 12 ulcerative colitis, 24 boys) in remission (n=26) or with only mild disease activity (n=13) were compared to 39 healthy age and sex-matched controls. Body weight, height, body mass index (BMI), lean body mass as phase angle α (determined by bioelectrical impedance analysis), and dynamometric grip force were expressed as age- and sex-related Z-scores. SenseWearPro(2) armbands were applied for three consecutive days to record number of steps, duration of physical activity and sleeping time. Quality of life was assessed with the German KINDL and IMPACT III questionnaires, energy intake with prospective food protocols. Differences between patients and pair-matched controls were analysed by paired t-test.
  
  
  RESULTS
  Patients showed lower Z-scores for phase angle α (difference -0.72; 95% CI [-1.10; -0.34]) and lower grip strength (-1.02 [-1.58; -0.47]) than controls. They tended towards lesser number of steps per day (-1339 [-2760; 83]) and shorter duration of physical activity (-0.44 h [-0.94; 0.06]), particularly in females and patients with mild disease. Quality of life and energy intake did not differ between patients and controls.
  
  
  CONCLUSIONS
  In spite of quiescent disease lean body mass and physical activity were reduced. Interventions to encourage physical activity may be beneficial in this lifelong disease.
authors.affiliation: Division of Paediatric Gastroenterology & Hepatology, Dr. von Hauner Children's Hospital, University of Munich Medical Center, Lindwurmstr. 4, 80337 München, Germany. katharina.werkstetter@med.uni-muenchen.de
authors.forename: Katharina J
authors.initials: KJ
authors.lastname: Werkstetter
authors.forename: Jennifer
authors.initials: J
authors.lastname: Ullrich
authors.forename: Stephanie B
authors.initials: SB
authors.lastname: Schatz
authors.forename: Christine
authors.initials: C
authors.lastname: Prell
authors.forename: Berthold
authors.initials: B
authors.lastname: Koletzko
authors.forename: Sibylle
authors.initials: S
authors.lastname: Koletzko
mesh_terms: D000293:Adolescent; D001823:Body Composition; D015992:Body Mass Index; D049628:Body Size; D016022:Case-Control Studies; D002648:Child; D003093:Colitis, Ulcerative / Q000473:pathology / Q000503:physiopathology / Q000523:psychology; D003424:Crohn Disease / Q000473:pathology / Q000503:physiopathology / Q000523:psychology; D018450:Disease Progression; D002149:Energy Intake; D004734:Energy Metabolism; D015444:Exercise; D005260:Female; D006801:Humans; D008297:Male; D053580:Muscle Strength; D011788:Quality of Life; D011795:Surveys and Questionnaires; D055815:Young Adult