title: Prolonged QTc interval and torsades de pointes induced by citalopram.
abstract: Citalopram is a selective serotonin reuptake inhibitor with a favorable cardiac-safety profile. Corrected QT interval (QTc) prolongation and cardiac arrhythmias have not been previously reported in association with citalopram use except in the presence of overdose, abnormal electrolyte values, or renal or liver failure. Herein, we report the case of a 40-year-old woman with mental depression who presented with a prolonged QTc interval and torsades de pointes after the initiation of citalopram at therapeutic doses. The QTc interval improved when citalopram therapy was discontinued. We recommend that clinicians investigate the family history for sudden deaths and perform baseline electrocardiography before prescribing citalopram. We also recommend routine electrocardiographic testing during citalopram therapy, and that patients with long QT syndrome avoid taking citalopram.
authors.affiliation: Department of Cardiovascular Medicine, The Cardiac Center of Creighton University, Omaha, Nebraska 68131, USA. drananddeshmukh@yahoo.com
authors.forename: Anand
authors.initials: A
authors.lastname: Deshmukh
authors.forename: Kyle
authors.initials: K
authors.lastname: Ulveling
authors.forename: Venkata
authors.initials: V
authors.lastname: Alla
authors.forename: Hussam
authors.initials: H
authors.lastname: Abuissa
authors.forename: Kelly
authors.initials: K
authors.lastname: Airey
mesh_terms: D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects*; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use; D015283:Citalopram / Q000009:adverse effects*; D003863:Depression / Q000188:drug therapy*; D057915:Drug Substitution; D004562:Electrocardiography; D005260:Female; D006329:Heart Conduction System / Q000187:drug effects* / Q000503:physiopathology; D006801:Humans; D008803:Mianserin / Q000031:analogs & derivatives / Q000627:therapeutic use; D000078785:Mirtazapine; D011237:Predictive Value of Tests; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects*; D013997:Time Factors; D016171:Torsades de Pointes / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology
chemical_list: D018687:Antidepressive Agents, Second-Generation; D000929:Antidepressive Agents, Tricyclic; D015283:Citalopram; D008803:Mianserin; D000078785:Mirtazapine; D017367:Selective Serotonin Reuptake Inhibitors