title: New cytotoxic cembranolides from the soft coral Lobophytum michaelae.
abstract: Six new cembranolides, michaolides L-Q (1-6), and a known cembranolide, lobomichaolide (7) were isolated from the CH₂Cl₂ extract of the soft coral Lobophytum michaelae. Their structures were established by extensive spectral analysis. The anti-HCMV (human cytomegalovirus) activity of 1-7 and their cytotoxicity against selected cell lines were evaluated.
authors.affiliation: Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
authors.forename: Shang-Kwei
authors.initials: SK
authors.lastname: Wang
authors.affiliation: Department of Marine Biotechnology and Resources, National Sun Yat-Sen University, Kaohsiung 804, Taiwan.|Asia-Pacific Ocean Research Center, National Sun Yat-Sen University, Kaohsiung 804, Taiwan.
authors.forename: Chang-Yih
authors.initials: CY
authors.lastname: Duh
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D045744:Cell Line, Tumor; D003587:Cytomegalovirus / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D055808:Drug Discovery; D006801:Humans; D020128:Inhibitory Concentration 50; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D008387:Marine Toxins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy; D010140:Pacific Ocean; D013237:Stereoisomerism; D013624:Taiwan
chemical_list: D000970:Antineoplastic Agents; D000998:Antiviral Agents; D004224:Diterpenes; D007783:Lactones; D008387:Marine Toxins; C078545:lobomichaolide