title: Prevalence and profile of mild cognitive impairment in Parkinson's disease.
abstract: OBJECTIVE
  The frequency of mild cognitive impairment (MCI) in Parkinson's disease (PD) ranges from 19 to 40%, and this is probably due to methodological differences between the studies. The aim of this study was to evaluate the frequency and profile of MCI in a large sample of nondemented PD subjects and neurologically healthy subjects (NHS).
  
  
  METHODS
  A total of 872 subjects (582 controls and 290 PD) were included. The association between MCI and PD was tested, using logistic regression models; odds ratios (OR) with 95% confidence intervals (CI) were calculated.
  
  
  RESULTS
  Fifty-three percent of PD subjects and 45% NHS met the criteria for MCI (p = 0.001). The PD subjects showed a higher frequency of nonamnestic MCI (naMCI), compared to NHS (23.8 vs. 14.4%, p ≤ 0.0001). In comparison to NHS, PD was associated with a univariate OR of 1.9 (95% CI = 1.3-2.8) for naMCI, and this association was marginally significant after multiple comparisons (multivariate OR = 1.5, 95% CI = 0.96-2.3, p = 0.077).
  
  
  CONCLUSIONS
  The association between PD and the impairment of nonmemory domains is probably due to frontal-subcortical involvement, which characterizes the disease.
authors.affiliation: Laboratory of Epidemiology and Psychology of Aging and Dementia, Department of Experimental Biomedicine and Clinical Neuroscience, University of Palermo, Palermo, Italy. roberto.monastero @ gmail.com
authors.forename: Roberto
authors.initials: R
authors.lastname: Monastero
authors.forename: Paola
authors.initials: P
authors.lastname: Di Fiore
authors.forename: Giusi Daniela
authors.initials: GD
authors.lastname: Ventimiglia
authors.forename: Caterina Claudia
authors.initials: CC
authors.lastname: Ventimiglia
authors.forename: Iacopo
authors.initials: I
authors.lastname: Battaglini
authors.forename: Rosolino
authors.initials: R
authors.lastname: Camarda
authors.forename: Cecilia
authors.initials: C
authors.lastname: Camarda
mesh_terms: D000368:Aged; D060825:Cognitive Dysfunction / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000453:epidemiology*; D015995:Prevalence; D012189:Retrospective Studies