title: [Enzymes of estrogen metabolism in breast cancer and their correlation with outcome].
abstract: The biopsy samples of 85 patients with breast cancer (BC) stage T1-3N0-3M0 were studied for estrogen metabolism enzymes (aromatase, 2,4-estrogene hydroxylase and gluthathion transferase) activity. This data was analyzed in relation to disease outcome. Aromatase activity in cancer tissue less than 20 fmol/ mg protein/h and 2,4-estrogene hydroxylase activity more than 230 pmol/mg protein/h proved to be the independent and significant predictors associated with worse relapse-free survival. The activity of gluthathiontransferase in tumor tissue less than 40 mkmol/mg protein/h is associated with worse metastatic-free survival. The activities of estrogen metabolism enzymes may be used as additional prognostic markers for breast cancer outcome.
authors.forename: E E
authors.initials: EE
authors.lastname: Shashova
authors.forename: I V
authors.initials: IV
authors.lastname: Kondakova
authors.forename: E M
authors.initials: EM
authors.lastname: Slonimskaia
authors.forename: S A
authors.initials: SA
authors.lastname: Glushchenko
mesh_terms: D000328:Adult; D000368:Aged; D001141:Aromatase / Q000378:metabolism*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000201:enzymology / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D004796:Clinical Enzyme Tests; D018572:Disease-Free Survival; D004967:Estrogens / Q000378:metabolism*; D005260:Female; D005982:Glutathione Transferase / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D013250:Steroid Hydroxylases / Q000378:metabolism*; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D004967:Estrogens; D013250:Steroid Hydroxylases; C571750:2,4-estrogen hydroxylase, human; D001141:Aromatase; D005982:Glutathione Transferase