title: Antidiabetic properties of ethanolic extract of Cnidoscolus aconitifolius on alloxan induced diabetes mellitus in rats.
abstract: This research was designed to investigate the antidiabetic properties of ethanolic extract of Cnidoscolus aconitifolius in alloxan-induced diabetes mellitus in Wistar male albino rats. Thirty male albino rats were used. Diabetes mellitus was induced in five of the six groups (B-F) by a single intra-peritoneal injection at the dose of 100mg/kg after normal fasting blood glucose had been determined. Group A served as the positive control while groups C-E received 100mg/kg, 500mg/kg and 1000mg/kg of Cnidoscolus aconitifolius extract respectively. Group B did not received any treatment while group F received chlorpropamide, a standard drug used in the treatment of diabetes mellitus. Blood glucose and body weights were monitored weekly for four weeks. Plasma lipids and electrolytes such as Total cholesterol, Triglyceride, Low Density Lipoproteins (LDL), High Density Lipoproteins (HDL), Creatinine and Blood Urea Nitrogen (BUN) were determined after four weeks of treatment with Cnidoscolus aconitifolius extract. The results show significant reduction (P<0.001) in the blood glucose in group C (100mg/kg of Cnidoscolus aconitifolius) when compared with diabetic control (Alloxan only) and other treatment groups. There was gradual increase in weight of all treatment groups compared with the diabetic control, which had progressive weight loss. Plasma cholesterol levels also significantly reduced (P<0.001) in rats treated with 1,000mg/kg Cnidoscolus aconitifolius extract. From this study, Cnidoscolus aconitifolius extract was found to considerably reduce blood glucose and plasma cholesterol levels and progressively increase weight gain in diabetic treated rats confirming its traditional use for the treatment of diabetes.
authors.affiliation: Department of Veterinary Physiology, Biochemistry and Pharmacology, College of Medicine, University of Ibadan, Ibadan, Nigeria. ademolaoyagbemi@yahoo.com
authors.forename: A A
authors.initials: AA
authors.lastname: Oyagbemi
authors.forename: A A
authors.initials: AA
authors.lastname: Odetola
authors.forename: O I
authors.initials: OI
authors.lastname: Azeez
mesh_terms: D000496:Alloxan; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D001835:Body Weight; D002747:Chlorpropamide / Q000627:therapeutic use; D002784:Cholesterol / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D000431:Ethanol; D019665:Euphorbiaceae / Q000737:chemistry*; D007004:Hypoglycemic Agents / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D007274:Injections, Intraperitoneal; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D018515:Plant Leaves / Q000737:chemistry; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D000431:Ethanol; D000496:Alloxan; D002784:Cholesterol; D002747:Chlorpropamide