title: Synthesis of hindered anilines: copper-catalyzed electrophilic amination of aryl boronic esters.
abstract: No longer a hindrance: copper-catalyzed electrophilic amination of aryl boronic esters is accomplished under mild reaction conditions using 2.5-5.0 mol % of a catalyst derived from copper tert-butoxide and Xantphos ligand. The reaction tolerates a wide range of functional groups and can be used to prepare some of the most hindered anilines made to date.
authors.affiliation: Department of Chemistry, University of Washington, Seattle, 98105, USA.
authors.forename: Richard P
authors.initials: RP
authors.lastname: Rucker
authors.forename: Aaron M
authors.initials: AM
authors.lastname: Whittaker
authors.forename: Hester
authors.initials: H
authors.lastname: Dang
authors.forename: Gojko
authors.initials: G
authors.lastname: Lalic
mesh_terms: D000586:Amination; D000814:Aniline Compounds / Q000737:chemistry*; D001895:Boron / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D004952:Esters; D010720:Phosphines / Q000737:chemistry; D014966:Xanthenes / Q000737:chemistry
chemical_list: D000814:Aniline Compounds; D004952:Esters; D010720:Phosphines; D014966:Xanthenes; D003300:Copper; D001895:Boron; C519861:xantphos; C023650:aniline