title: Feasibility and acceptability of gentamicin in the Uniject prefilled injection system for community-based treatment of possible neonatal sepsis: the experience of female community health volunteers in Nepal.
abstract: OBJECTIVE
  Explore feasibility and acceptability of gentamicin in the Uniject prefilled injection system, in combination with oral cotrimoxazole-p and an appropriate newborn weighing scale, for treatment of possible neonatal sepsis when administered in the community by female community health volunteers.
  
  
  METHODS
  In a community-based program in Nepal, 45 volunteers recorded 422 live births. Among these, 82 infants were identified as having possible severe bacterial infection. In all, 67 of these infants were treated with gentamicin in Uniject and 15 were referred to the health facility. Mixed methods were used to collect data about Uniject performance, acceptability and safety.
  
  
  RESULTS
  Volunteers successfully treated 67 infants with gentamicin in Uniject. Gentamicin in Uniject performed well and was acceptable.
  
  
  CONCLUSIONS
  Gentamicin in Uniject, in combination with cotrimoxazole-p and an appropriate newborn weighing scale, is a feasible and acceptable option for treatment of possible neonatal sepsis in the community by female community health volunteers.
authors.affiliation: PATH, Seattle, WA 98109, USA. pcoffey@path.org
authors.forename: P S
authors.initials: PS
authors.lastname: Coffey
authors.forename: J
authors.initials: J
authors.lastname: Sharma
authors.forename: K C
authors.initials: KC
authors.lastname: Gargi
authors.forename: D
authors.initials: D
authors.lastname: Neupane
authors.forename: P
authors.initials: P
authors.lastname: Dawson
authors.forename: Y V
authors.initials: YV
authors.lastname: Pradhan
mesh_terms: D000328:Adult; D003153:Community Health Services / Q000379:methods*; D003906:Developing Countries; D004305:Dose-Response Relationship, Drug; D016503:Drug Delivery Systems / Q000295:instrumentation*; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D005839:Gentamicins / Q000008:administration & dosage*; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000401:mortality; D007273:Injections, Intramuscular; D008297:Male; D009390:Nepal; D017063:Outcome Assessment, Health Care; D010342:Patient Acceptance of Health Care; D018570:Risk Assessment; D018805:Sepsis / Q000175:diagnosis / Q000188:drug therapy* / Q000401:mortality; D013594:Syringes; D016896:Treatment Outcome; D014838:Volunteers
chemical_list: D005839:Gentamicins