title: Liver enzymes concentrations are closely related to prediabetes: findings of the Shanghai Diabetes Study II (SHDS II).
abstract: OBJECTIVE
  To investigate the relationship of liver enzymes with hyperglycemia in a large population in Shanghai and identify the association between liver enzymes and insulin resistance.
  
  
  METHODS
  A total of 3 756 participants were enrolled. Each participant underwent an oral glucose tolerance test and completed a questionnaire. Anthropometric indices were recorded and serum samples were collected for measurement.
  
  
  RESULTS
  Liver enzymes concentrations were independently associated with i-IGT, IFG+IGT, and diabetes. With the increase of ALT and GGT concentrations, ORs for i-IGT, IFG+IGT, and diabetes increased gradually. By comparing patients in the highest quartile of GGT concentrations or ALT concentrations with those in the lowest quartile (Q1), ORs for i-IGT, IFG+IGT, or diabetes was significant after adjustment. Both ALT and GGT concentrations were linearly correlated with HOMA-IR and independently associated with HOMA-IR [ALT OR (95% CI): 2.56 (1.51-4.34) P=0.00; GGT OR (95% CI): 2.66 (1.53-4.65) P=0.00].
  
  
  CONCLUSIONS
  Serum ALT and GGT concentrations were closely related to pre-diabetes and diabetes in the Shanghai population and positively associated with insulin resistance.
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai, China.
authors.forename: Fei
authors.initials: F
authors.lastname: Gao
authors.forename: Jie Min
authors.initials: JM
authors.lastname: Pan
authors.forename: Xu Hong
authors.initials: XH
authors.lastname: Hou
authors.forename: Qi Chen
authors.initials: QC
authors.lastname: Fang
authors.forename: Hui Juan
authors.initials: HJ
authors.lastname: Lu
authors.forename: Jun Ling
authors.initials: JL
authors.lastname: Tang
authors.forename: Hui Lin
authors.initials: HL
authors.lastname: Gu
authors.forename: Zhi Jian
authors.initials: ZJ
authors.lastname: Pan
authors.forename: You Hua
authors.initials: YH
authors.lastname: Yao
authors.forename: Wei Zhen
authors.initials: WZ
authors.lastname: Shen
authors.forename: Wei Ping
authors.initials: WP
authors.lastname: Jia
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood*; D000886:Anthropometry; D002681:China; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism; D008099:Liver / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D011236:Prediabetic State / Q000097:blood / Q000201:enzymology*; D055815:Young Adult; D005723:gamma-Glutamyltransferase / Q000097:blood*
chemical_list: D000410:Alanine Transaminase; D006442:Glycated Hemoglobin; D005723:gamma-Glutamyltransferase