title: Gold nanoparticles-decorated silicon nanowires as highly efficient near-infrared hyperthermia agents for cancer cells destruction.
abstract: Near-infrared (NIR) hyperthermia agents are of current interest because they hold great promise as highly efficacious tools for cancer photothermal therapy. Although various agents have been reported, a practical NIR hyperthermia agent is yet unavailable. Here, we present the first demonstration that silicon nanomaterials-based NIR hyperthermia agent, that is, gold nanoparticles-decorated silicon nanowires (AuNPs@SiNWs), is capable of high-efficiency destruction of cancer cells. AuNPs@SiNWs are found to possess strong optical absorbance in the NIR spectral window, producing sufficient heat under NIR irradiation. AuNPs@SiNWs are explored as novel NIR hyperthermia agents for photothermal ablation of tumor cells. In particular, three different cancer cells treated with AuNPs@SiNWs were completely destructed within 3 min of NIR irradiation, demonstrating the exciting potential of AuNPs@SiNWs for NIR hyperthermia agents.
authors.affiliation: Institute of Functional Nano and Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Soochow University, Suzhou 215123, China.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Su
authors.forename: Xinpan
authors.initials: X
authors.lastname: Wei
authors.forename: Fei
authors.initials: F
authors.lastname: Peng
authors.forename: Yiling
authors.initials: Y
authors.lastname: Zhong
authors.forename: Yimei
authors.initials: Y
authors.lastname: Lu
authors.forename: Shao
authors.initials: S
authors.lastname: Su
authors.forename: Tingting
authors.initials: T
authors.lastname: Xu
authors.forename: Shuit-Tong
authors.initials: ST
authors.lastname: Lee
authors.forename: Yao
authors.initials: Y
authors.lastname: He
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D006046:Gold / Q000737:chemistry / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D007624:KB Cells; D007834:Lasers; D053768:Metal Nanoparticles / Q000737:chemistry*; D053770:Nanowires / Q000737:chemistry*; D009369:Neoplasms / Q000473:pathology*; D010316:Particle Size; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry / Q000494:pharmacology*; D012825:Silicon / Q000737:chemistry / Q000494:pharmacology*; D019265:Spectroscopy, Near-Infrared; D013329:Structure-Activity Relationship; D013499:Surface Properties; D013997:Time Factors; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D017319:Photosensitizing Agents; D006046:Gold; D012825:Silicon