title: LAPTM4B polymorphisms is associated with ovarian cancer susceptibility and its prognosis.
abstract: OBJECTIVE
  Lysosome-associated protein transmembrane 4 beta (LAPTM4B) is an important novel gene associated with the proliferation and differentiation of cells. Recent studies have shown that it was overexpressed in many cancer tissues. This study investigated the association between different LAPTM4B polymorphisms and the susceptibility and prognosis of ovarian cancer.
  
  
  METHODS
  A case-control study was performed in 282 patients with ovarian cancer and 365 control subjects. Genomic DNA was extracted from peripheral blood lymphocytes in all participants. LAPTM4B genotypes were determined using polymerase chain reaction.
  
  
  RESULTS
  There was a significantly higher LAPTM4B 2 allele frequency in ovarian cancer cases than controls (P < 0.05). Using the LAPTM4B 1/1 genotype as the reference, we found that the LAPTM4B 1/2 and LAPTM4B 2/2 genotypes were positively associated with ovarian cancer. Additionally, we found a negative correlation between the tumor grade and LAPTM4B allele genotype, which indicates strongly that LAPTM4B 2 could affect the survival of patients.
  
  
  CONCLUSIONS
  These findings indicate that the LAPTM4B 2 allele may be a risk factor for ovarian cancer and may play an important role in genetic susceptibility to ovarian cancer.
authors.affiliation: Department of Gynecology, The Affiliated Tumor Hospital, Harbin Medical University, Harbin 150081, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Xu
authors.forename: Yunduo
authors.initials: Y
authors.lastname: Liu
authors.forename: Rouli
authors.initials: R
authors.lastname: Zhou
authors.forename: Fanling
authors.initials: F
authors.lastname: Meng
authors.forename: Ying
authors.initials: Y
authors.lastname: Gao
authors.forename: Shanshan
authors.initials: S
authors.lastname: Yang
authors.forename: Xueting
authors.initials: X
authors.lastname: Li
authors.forename: Meng
authors.initials: M
authors.lastname: Yang
authors.forename: Ge
authors.initials: G
authors.lastname: Lou
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics; D000328:Adult; D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D018282:Cystadenocarcinoma, Mucinous / Q000235:genetics; D018284:Cystadenocarcinoma, Serous / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D053208:Kaplan-Meier Estimate; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D060787:Neoplasm Grading; D015513:Oncogene Proteins / Q000235:genetics*; D010051:Ovarian Neoplasms / Q000235:genetics*; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D016016:Proportional Hazards Models; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: C477083:LAPTM4B protein, human; D008565:Membrane Proteins; D015513:Oncogene Proteins