title: Use of iris recognition camera technology for the quantification of corneal opacification in mucopolysaccharidoses.
abstract: Mucopolysaccharidoses (MPS) can cause corneal opacification that is currently difficult to objectively quantify. With newer treatments for MPS comes an increased need for a more objective, valid and reliable index of disease severity for clinical and research use. Clinical evaluation by slit lamp is very subjective and techniques based on colour photography are difficult to standardise. In this article the authors present evidence for the utility of dedicated image analysis algorithms applied to images obtained by a highly sophisticated iris recognition camera that is small, manoeuvrable and adapted to achieve rapid, reliable and standardised objective imaging in a wide variety of patients while minimising artefactual interference in image quality.
authors.affiliation: Manchester Royal Eye Hospital, Oxford Road, Manchester M13 9WL, UK. vtariq.aslam@cmft.nhs.uk
authors.forename: Tariq Mehmood
authors.initials: TM
authors.lastname: Aslam
authors.forename: Savana
authors.initials: S
authors.lastname: Shakir
authors.forename: James
authors.initials: J
authors.lastname: Wong
authors.forename: Leon
authors.initials: L
authors.lastname: Au
authors.forename: Jane
authors.initials: J
authors.lastname: Ashworth
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003318:Corneal Opacity / Q000175:diagnosis* / Q000209:etiology; D003941:Diagnostic Techniques, Ophthalmological / Q000295:instrumentation*; D004867:Equipment Design; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007498:Iris / Q000473:pathology*; D008297:Male; D009083:Mucopolysaccharidoses / Q000150:complications* / Q000175:diagnosis; D010781:Photography / Q000379:methods*; D015203:Reproducibility of Results