title: Insulin-like growth factor I and anthropometric parameters in a Danish population.
abstract: During the last decade several studies indicated that low insulin-like growth factor (IGF) I levels are related to higher risk of cardiovascular disease and mortality. Obesity represents one further main cardiovascular risk factor which might also be related to IGF-I. The objective of the present study was to analyse the associations between anthropometric measures and IGF-I levels in a population-based sample. From the Danish cross-sectional Health2006 study 3,328 subjects (1,835 women; 1,493 men) aged 19-72 years were included in the analyses. Serum IGF-I levels were determined by an immunoassay. Body height, weight as well as waist and hip circumferences were measured. Body-mass-index, waist-to-hip ratio and waist-to-height ratio were calculated. Circulating IGF-I levels were inversely associated with all anthropometric markers as evaluated by linear regression adjusting for age, alcohol consumption, smoking and physical activity. Our large cross-sectional study suggests that IGF-I may serve as the link between obesity and mortality although any causal relation cannot be inferred and longitudinal analyses are needed to clarify the causal relation.
authors.affiliation: Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Germany. nele.friedrich@uni-greifswald.de
authors.forename: N
authors.initials: N
authors.lastname: Friedrich
authors.forename: T
authors.initials: T
authors.lastname: Jørgensen
authors.forename: A
authors.initials: A
authors.lastname: Juul
authors.forename: C
authors.initials: C
authors.lastname: Spielhagen
authors.forename: M
authors.initials: M
authors.lastname: Nauck
authors.forename: H
authors.initials: H
authors.lastname: Wallaschofski
authors.forename: A
authors.initials: A
authors.lastname: Linneberg
mesh_terms: D000328:Adult; D000368:Aged; D000886:Anthropometry / Q000379:methods; D015992:Body Mass Index; D001837:Body Weights and Measures / Q000379:methods; D003718:Denmark; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011153:Population; D055105:Waist Circumference / Q000502:physiology; D049629:Waist-Hip Ratio; D055815:Young Adult
chemical_list: D007334:Insulin-Like Growth Factor I