title: Sensitivity and specificity of Addenbrooke's Cognitive Examination, Mattis Dementia Rating Scale, Frontal Assessment Battery and Mini Mental State Examination for diagnosing dementia in Parkinson's disease.
abstract: BACKGROUND
  Among the non-motor features of Parkinson's disease (PD), cognitive impairment is one of the most troublesome problems. Highly sensitive and specific screening instruments for detecting dementia in PD (PDD) are required in the clinical practice.
  
  
  METHODS
  In our study we evaluated the sensitivity and specificity of different neuropsychological tests (Addenbrooke's Cognitive Examination, ACE; Frontal Assessment Battery, FAB and Mattis Dementia Rating Scale, MDRS) in 73 Parkinson's disease patients without depression. By receiver operating characteristic curve analysis, these screening instruments were tested against the recently established clinical diagnostic criteria of PDD.
  
  
  RESULTS
  Best cut-off score for ACE to identify PDD was 80 points (sensitivity = 74.0%, specificity = 78.1%). For FAB the most optimal cut-off value was 12 points (sensitivity = 66.3%, specificity = 72.2%); whereas for MDRS it was 125 points (sensitivity = 89.8%, specificity = 98.3%). Among the examined test batteries, MDRS had the best clinicometric profile for detecting PDD.
  
  
  CONCLUSIONS
  Although the types of applied screening instruments might differ from movement disorder clinic to clinic within a country, determination of the most specific and sensitive test for the given population remains to be an important task. Our results demonstrated that the specificity and sensitivity of MDRS was better than those of ACE, FAB and MMSE in Hungary. However, further studies with larger sample size and more uniform criteria for participation are required to determine the most suitable screening instrument for cognitive impairment.
authors.affiliation: Institute of Behavioral Sciences, Faculty of Medicine, University of Pécs, Szigeti u. 12., 7624 Pecs, Baranya, Hungary.
authors.forename: B
authors.initials: B
authors.lastname: Kaszás
authors.forename: N
authors.initials: N
authors.lastname: Kovács
authors.forename: I
authors.initials: I
authors.lastname: Balás
authors.forename: J
authors.initials: J
authors.lastname: Kállai
authors.forename: Z
authors.initials: Z
authors.lastname: Aschermann
authors.forename: Z
authors.initials: Z
authors.lastname: Kerekes
authors.forename: S
authors.initials: S
authors.lastname: Komoly
authors.forename: F
authors.initials: F
authors.lastname: Nagy
authors.forename: J
authors.initials: J
authors.lastname: Janszky
authors.forename: T
authors.initials: T
authors.lastname: Lucza
authors.forename: K
authors.initials: K
authors.lastname: Karádi
mesh_terms: D000328:Adult; D000368:Aged; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology; D003704:Dementia / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008609:Mental Status Schedule; D008875:Middle Aged; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000150:complications; D012372:ROC Curve; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index