title: Sentinel lymph node biopsy for T1/T2 oral cavity squamous cell carcinoma--a prospective case series.
abstract: BACKGROUND
  Sentinel lymph node biopsy (SLNB) is an established technique in breast and melanoma surgery and is gaining acceptance in the management of oral cavity squamous cell carcinoma. We report a single institution's experience of SLNB between 2006 and 2010.
  
  
  METHODS
  Prospective consecutive cohort study of 59 patients recruited between 2006 and 2010. All patients underwent SLNB with preoperative lymphoscintigraphy, intraoperative blue dye, and handheld gamma probe. Sentinel nodes were evaluated with step-serial sectioning and immunohistochemistry. Endpoints included: overall survival (OS), disease-specific survival (DSS), local recurrence-free survival (LRFS), and regional recurrence-free survival (RRFS).
  
  
  RESULTS
  A total of 59 patients (36 male and 23 female) were operated on. Of these, 42 patients (71%) were pT1 and 17 patients (29%) were pT2. In two patients the sentinel node was not identified and proceeded to elective neck dissection. A total of 150 nodes were harvested from the remaining 57 patients of which 21 nodes were positive in 17 patients; three patients had positive contralateral nodes. The 2-year OS, DSS, LRFS, and RRFS for the SLNB negative patients were 97.5, 100, 95.8, and 95.8% and for the SLNB positive patients 68.2, 81.8, 83.9, and 100% respectively. Only OS and DSS approached statistical significance with P values of 0.07 and 0.06.
  
  
  CONCLUSIONS
  SLNB is a safe and accurate diagnostic technique for staging the neck with a negative predictive value in our series of 97.5%. Furthermore, in our series three patients (5%) had positive contralateral neck drainage that would have been missed by conventional ipsilateral neck dissection.
authors.affiliation: Department of Head & Neck Surgery, Guy's & St. Thomas's Hospital NHS Trust, London, UK.
authors.forename: Thomas
authors.initials: T
authors.lastname: Pezier
authors.forename: Iain J
authors.initials: IJ
authors.lastname: Nixon
authors.forename: Ben
authors.initials: B
authors.lastname: Gurney
authors.forename: Clare
authors.initials: C
authors.lastname: Schilling
authors.forename: Karim
authors.initials: K
authors.lastname: Hussain
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Lyons
authors.forename: Richard
authors.initials: R
authors.lastname: Oakley
authors.forename: Ricard
authors.initials: R
authors.lastname: Simo
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Jeannon
authors.forename: Mark
authors.initials: M
authors.lastname: McGurk
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008198:Lymph Nodes / Q000473:pathology* / Q000601:surgery*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D037981:Neck Dissection; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D018714:Radiotherapy, Adjuvant; D021701:Sentinel Lymph Node Biopsy