title: Cis-vaccenic acid and the Framingham risk score predict chronic kidney disease: the multi-ethnic study of atherosclerosis (MESA).
abstract: BACKGROUND
  Data on the associations of fatty acids with chronic kidney disease (CKD) are sparse.
  
  
  METHODS
  We performed a cross-sectional study of 2792 men and women from the MESA cohort of African-American, Caucasian, Chinese and Hispanic adults without known cardiovascular disease. Plasma phospholipid fatty acid proportions were associated with estimated glomerular filtration rate (eGFR) and the albumin/creatinine ratio.
  
  
  RESULTS
  Cis-vaccenic acid (18:1n-7), adjusted for other fatty acids using multivariate logistic regression (CI: 1.0-1.4), and step-wise logistic regression (CI: 1.02-1.42), was positively associated with reduced eGFR. The Framingham Risk Score, when adjusting for fatty acid proportions and demographic factors, was positively associated with CKD as measured by the eGFR and the albumin/creatinine ratio.
  
  
  CONCLUSIONS
  Plasma phospholipid proportions of the 18 carbon monounsaturated cis-vaccenic acid {18:1n-7}) and the Framingham Risk Score are associated with kidney function. The potential role of 18:1n-7 in the development of CKD warrants further investigation.
authors.affiliation: Department of Community and Preventive Medicine, Division of Epidemiology, the University of Rochester School of Medicine, Rochester, NY 14642, USA. robert_block@urmc.rochester.edu
authors.forename: Robert
authors.initials: R
authors.lastname: Block
authors.forename: Lisa
authors.initials: L
authors.lastname: Kakinami
authors.forename: Scott
authors.initials: S
authors.lastname: Liebman
authors.forename: Gregory C
authors.initials: GC
authors.lastname: Shearer
authors.forename: Holly
authors.initials: H
authors.lastname: Kramer
authors.forename: Michael
authors.initials: M
authors.lastname: Tsai
mesh_terms: D000368:Aged; D001213:Asian; D050197:Atherosclerosis / Q000150:complications*; D044383:Black People; D003404:Creatinine / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D005919:Glomerular Filtration Rate; D006630:Hispanic or Latino; D006801:Humans; D007676:Kidney Failure, Chronic / Q000208:ethnology* / Q000209:etiology / Q000503:physiopathology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009829:Oleic Acids / Q000097:blood*; D012307:Risk Factors; D044465:White People; D001741:Black or African American
chemical_list: D009829:Oleic Acids; C065593:cis-vaccenic acid; D003404:Creatinine