title: Novel postoperative use of beta-blocking medication for infants with left ventricular outflow obstruction and diastolic myocardial dysfunction.
abstract: Severe left ventricular outflow obstruction often is associated with diastolic left ventricular myocardial dysfunction and tachycardia despite successful initial treatment. The authors have used esmolol to lower heart rate in this setting for successful weaning of patients from ventilation in postoperative recovery. Their limited experience supports the beneficial effect of continuous esmolol administration on infants with persistent tachycardia and severe left ventricular diastolic dysfunction in postoperative cardiac intensive care.
authors.affiliation: Department of Pediatrics, Royal Brompton and Harefield NHS Foundation Trust, Royal Brompton Hospital, Sydney Street, London, SW3 6NP, UK. a.furck@rbht.nhs.uk
authors.forename: Anke K
authors.initials: AK
authors.lastname: Furck
authors.forename: Ajay
authors.initials: A
authors.lastname: Desai
authors.forename: Duncan J
authors.initials: DJ
authors.lastname: Macrae
authors.forename: Zdenek
authors.initials: Z
authors.lastname: Slavik
mesh_terms: D058671:Adrenergic beta-1 Receptor Antagonists / Q000627:therapeutic use*; D003971:Diastole; D015150:Echocardiography, Doppler; D006330:Heart Defects, Congenital / Q000601:surgery*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D011412:Propanolamines / Q000627:therapeutic use*; D013610:Tachycardia / Q000188:drug therapy*; D015300:Ventilator Weaning; D014694:Ventricular Outflow Obstruction / Q000188:drug therapy*
chemical_list: D058671:Adrenergic beta-1 Receptor Antagonists; D011412:Propanolamines; C036604:esmolol