title: The effect of ethanol on the formation of N2-ethylidene-dG adducts in mice: implications for alcohol-related carcinogenicity of the oral cavity and esophagus.
abstract: The present study aimed to experimentally confirm that long-term alcohol drinking causes a high risk of oral and esophageal cancer in aldehyde dehydrogenase 2 (ALDH2)-deficient individuals. Aldh2 knockout mice, an animal model of ALDH2-deficiency, were treated with 8% ethanol for 14 months. Levels of acetaldehyde-derived DNA adducts were increased in esophagus, tongue and submandibular gland. Our finding that a lack of Aldh2 leads to more DNA damage after chronic ethanol treatment in mice supports epidemiological findings on the carcinogenicity of alcohol in ALDH2-deficient individuals who drink chronically.
authors.affiliation: Department of Environmental Health, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan.
authors.forename: Hsu-Sheng
authors.initials: HS
authors.lastname: Yu
authors.forename: Tsunehiro
authors.initials: T
authors.lastname: Oyama
authors.forename: Tomonari
authors.initials: T
authors.lastname: Matsuda
authors.forename: Toyohi
authors.initials: T
authors.lastname: Isse
authors.forename: Tetsunosuke
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: Masayuki
authors.initials: M
authors.lastname: Tanaka
authors.forename: Mayumi
authors.initials: M
authors.lastname: Tsuji
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Kawamoto
mesh_terms: D000818:Animals; D002273:Carcinogens / Q000494:pharmacology*; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000633:toxicity; D004938:Esophageal Neoplasms / Q000139:chemically induced*; D000431:Ethanol / Q000494:pharmacology*; D051379:Mice; D009062:Mouth Neoplasms / Q000139:chemically induced*
chemical_list: D002273:Carcinogens; C525837:N2-ethylidene-2'-deoxyguanosine; D000431:Ethanol; D003849:Deoxyguanosine