title: Caveolin-1 and prostate cancer progression.
abstract: Caveolin-1 was identified in the 1990s as a marker of aggressive prostate cancer. The caveolin-1 protein localizes to vesicular structures called caveolae and has been shown to bind and regulate many signaling proteins involved in oncogenesis. Caveolin-1 also has lipid binding properties and mediates aspects of cholesterol and fatty acid metabolism and can elicit biological responses in a paracrine manner when secreted. Caveolin-1 is also present in the serum of prostate cancer patients and circulating levels correlate with extent of disease. Current evidence indicates that increased expression of caveolin-1 in prostate adenocarcinoma cells and commensurate downregulation of the protein in prostate stroma, mediate progression to the castration-resistant phase of prostate cancer through diverse pathways. This chapter summarizes the current state of our understanding of the cellular and physiologic mechanisms in which caveolin-1 participates in the evolution of prostate cancer cell phenotypes.
authors.affiliation: Children's Hospital Boston, Boston, MA, USA. michael.freeman@childrens.harvard.edu
authors.forename: Michael R
authors.initials: MR
authors.lastname: Freeman
authors.forename: Wei
authors.initials: W
authors.lastname: Yang
authors.forename: Dolores
authors.initials: D
authors.lastname: Di Vizio
mesh_terms: D000728:Androgens / Q000378:metabolism; D000818:Animals; D051242:Caveolin 1 / Q000378:metabolism; D018450:Disease Progression; D006801:Humans; D008297:Male; D011471:Prostatic Neoplasms / Q000378:metabolism / Q000473:pathology; D011944:Receptors, Androgen / Q000378:metabolism; D017154:Stromal Cells / Q000378:metabolism / Q000473:pathology
chemical_list: D000728:Androgens; D051242:Caveolin 1; D011944:Receptors, Androgen