title: The ABA-INSENSITIVE-4 (ABI4) transcription factor links redox, hormone and sugar signaling pathways.
abstract: The cellular reduction-oxidation (redox) hub processes information from metabolism and the environment and so regulates plant growth and defense through integration with the hormone signaling network. One key pathway of redox control involves interactions with ABSCISIC ACID (ABA). Accumulating evidence suggests that the ABA-INSENSITIVE-4 (ABI4) transcription factor plays a key role in transmitting information concerning the abundance of ascorbate and hence the ability of cells to buffer oxidative challenges. ABI4 is required for the ascorbate-dependent control of growth, a process that involves enhancement of salicylic acid (SA) signaling and inhibition of jasmonic acid (JA) signaling pathways. Low redox buffering capacity reinforces SA- JA- interactions through the mediation of ABA and ABI4 to fine-tune plant growth and defense in relation to metabolic cues and environmental challenges. Moreover, ABI4-mediated pathways of sugar sensitivity are also responsive to the abundance of ascorbate, providing evidence of overlap between redox and sugar signaling pathways.
authors.affiliation: Centre for Plant Sciences, Faculty of Biology, University of Leeds, Leeds, UK. c.foyer@leeds.ac.uk
authors.forename: Christine H
authors.initials: CH
authors.lastname: Foyer
authors.forename: Pavel I
authors.initials: PI
authors.lastname: Kerchev
authors.forename: Robert D
authors.initials: RD
authors.lastname: Hancock
mesh_terms: D000040:Abscisic Acid / Q000378:metabolism*; D017360:Arabidopsis / Q000254:growth & development / Q000378:metabolism*; D029681:Arabidopsis Proteins / Q000235:genetics / Q000378:metabolism*; D001205:Ascorbic Acid / Q000378:metabolism; D002241:Carbohydrates / Q000502:physiology*; D003517:Cyclopentanes / Q000378:metabolism; D018506:Gene Expression Regulation, Plant; D017343:Genes, Plant; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D054883:Oxylipins / Q000378:metabolism; D010937:Plant Growth Regulators / Q000378:metabolism*; D020156:Salicylic Acid / Q000378:metabolism; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D029681:Arabidopsis Proteins; D002241:Carbohydrates; D003517:Cyclopentanes; D054883:Oxylipins; D010937:Plant Growth Regulators; D014157:Transcription Factors; C011006:jasmonic acid; D000040:Abscisic Acid; D020156:Salicylic Acid; D001205:Ascorbic Acid