title: Enhanced photochemical [6π] electrocyclization within the lipophilic protein binding site.
abstract: Photocyclization of N-methyldiphenylamine to N-methylcarbazole is achieved within the microenvironment provided by site I of serum albumins. Quantum yield determinations, combined with transient absorption spectroscopic detection of the dihydrocarbazole intermediate, demonstrate that protein encapsulation provides a subtle control of the kinetic parameters, leading to optimized efficiencies.
authors.affiliation: Instituto de Tecnología Química UPV-CSIC, Universidad Politecnica de Valencia, Avda de Los Naranjos s/n, 46022 Valencia, Spain.
authors.forename: Mireia
authors.initials: M
authors.lastname: Marin
authors.forename: Virginie
authors.initials: V
authors.lastname: Lhiaubet-Vallet
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Miranda
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry; D000818:Animals; D001665:Binding Sites; D002227:Carbazoles / Q000737:chemistry; D002417:Cattle; D003500:Cyclization; D006801:Humans; D007700:Kinetics; D008956:Models, Chemical; D015394:Molecular Structure; D011485:Protein Binding; D012709:Serum Albumin / Q000737:chemistry*
chemical_list: D000814:Aniline Compounds; D002227:Carbazoles; D012709:Serum Albumin; C038545:N-methylcarbazole