title: [Borderline resectable pancreatic cancer - a definition and effective treatment strategy].
abstract: The survival benefit of extended surgery for advanced pancreatic cancer has been denied by four randomized controlled trials. However, there still is confusion and conflict over the definition and effective treatment strategy for so-called locally advanced or borderline resectable pancreatic cancer. Although there are a number of reports that showed outcomes of preoperative chemotherapy or chemoradiotherapy for this disease, the definitions and treatment regimens described in these studies vary. Moreover, all of the studies were Phase I / II trials or retrospective analysis, and there is no Phase III trial currently focused on this issue. It is urgently necessary to establish an international consensus on the definition of borderline resectable pancreatic cancer. The usefulness of neoadjuvant treatment for this disease should also be elucidated in future clinical trials. In this review article, we discuss the current understanding and definition of borderline resectable pancreatic cancer, and the value of neoadjuvant treatment strategy for treating it.
authors.affiliation: Dept. of Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Yukihiro
authors.initials: Y
authors.lastname: Yokoyama
authors.forename: Tomoki
authors.initials: T
authors.lastname: Ebata
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Igami
authors.forename: Gen
authors.initials: G
authors.lastname: Sugawara
authors.forename: Yuh
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Toshio
authors.initials: T
authors.lastname: Kokuryo
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Tsunoda
authors.forename: Masahide
authors.initials: M
authors.lastname: Fukaya
authors.forename: Keisuke
authors.initials: K
authors.lastname: Uehara
authors.forename: Keita
authors.initials: K
authors.lastname: Itatsu
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Yoshioka
authors.forename: Masato
authors.initials: M
authors.lastname: Nagino
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D006801:Humans; D020360:Neoadjuvant Therapy; D009389:Neovascularization, Pathologic / Q000601:surgery; D010180:Pancreatectomy / Q000592:standards*; D010190:Pancreatic Neoplasms / Q000098:blood supply / Q000188:drug therapy / Q000601:surgery*
chemical_list: D000970:Antineoplastic Agents