title: Myocardial infarction and generalised anxiety disorder: 10-year follow-up.
abstract: BACKGROUND
  Few studies have addressed the relationship between generalised anxiety disorder and cardiovascular prognosis using a diagnostic interview.
  
  
  OBJECTIVE
  To assess the association between generalised anxiety disorder and adverse outcomes in patients with myocardial infarction.
  
  
  METHODS
  Patients with acute myocardial infarction (n = 438) were recruited between 1997 and 2000 and were followed up until 2007. Current generalised anxiety disorder and post-myocardial infarction depression were assessed with the Composite International Diagnostic Interview. The end-point consisted of all-cause mortality and cardiovascular-related readmissions.
  
  
  RESULTS
  During the follow-up period, 198 patients had an adverse event. Generalised anxiety disorder was associated with an increased rate of adverse events after adjustment for age and gender (hazard ratio: 1.94; 95% confidence interval: 1.14-3.30; P = 0.01). Additional adjustment for measures of cardiac disease severity and depression did not change the results.
  
  
  CONCLUSIONS
  Generalised anxiety disorder was associated with an almost twofold increased risk of adverse outcomes independent demographic and clinical variables and depression.
authors.affiliation: Department of Psychiatry, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands.
authors.forename: Annelieke M
authors.initials: AM
authors.lastname: Roest
authors.forename: Marij
authors.initials: M
authors.lastname: Zuidersma
authors.forename: Peter
authors.initials: P
authors.lastname: de Jonge
mesh_terms: D001008:Anxiety Disorders / Q000453:epidemiology*; D001145:Arrhythmias, Cardiac / Q000453:epidemiology; D002561:Cerebrovascular Disorders / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology*; D017202:Myocardial Ischemia / Q000453:epidemiology; D009426:Netherlands / Q000453:epidemiology; D017063:Outcome Assessment, Health Care; D016491:Peripheral Vascular Diseases / Q000453:epidemiology; D011379:Prognosis; D012307:Risk Factors