title: Vitamin D supplementation in the treatment of atopic dermatitis: a clinical trial study.
abstract: BACKGROUND
  The role of vitamin D in Atopic Dermatitis (AD) is ambiguous and clinical trials are needed to assess the role of vitamin D in the treatment of AD. The aim of this clinical trial study to evaluate the effect of vitamin D supplementation on patients with AD.
  
  
  METHODS
  sixty AD patients were included in a randomized, double-blind, placebo-controlled trial study. They were randomly divided into two groups and treated for 60 days: group vitamin D (n=30), and placebo group (n=30). The two groups were as follows: Group D, 1600 IU cholecalciferol (vitamin D) and second group placebo. The severity of AD was evaluated based on SCORAD (Scoring Atopic Dermatitis) and TIS (Three Item Severity score) value by the same trained physician before and after the trial.
  
  
  RESULTS
  According to SCORAD and TIS value index in the vitamin D group showed significant improvement in patients with mild, moderate and severe AD (P<0.05) and in patients who the intake placebo, this improvement didn't showed (P>0.05).
  
  
  CONCLUSIONS
  Results mention that supplementation with oral vitamin D dramatically improved disease severity in AD patients.
authors.affiliation: Orumieh University of Medical Science, Orumieh, Iran.
authors.forename: Morteza
authors.initials: M
authors.lastname: Amestejani
authors.forename: Bahareh Seyed
authors.initials: BS
authors.lastname: Salehi
authors.forename: Mostafa
authors.initials: M
authors.lastname: Vasigh
authors.forename: Azadeh
authors.initials: A
authors.lastname: Sobhkhiz
authors.forename: Mehdi
authors.initials: M
authors.lastname: Karami
authors.forename: Hossein
authors.initials: H
authors.lastname: Alinia
authors.forename: Seyed Kamran
authors.initials: SK
authors.lastname: Kamrava
authors.forename: Navab
authors.initials: N
authors.lastname: Shamspour
authors.forename: Babak
authors.initials: B
authors.lastname: Ghalehbaghi
authors.forename: Ashkan Heshmatzade
authors.initials: AH
authors.lastname: Behzadi
mesh_terms: D000284:Administration, Oral; D000328:Adult; D002762:Cholecalciferol / Q000008:administration & dosage / Q000627:therapeutic use*; D003876:Dermatitis, Atopic / Q000188:drug therapy* / Q000473:pathology; D004311:Double-Blind Method; D006801:Humans; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014815:Vitamins / Q000008:administration & dosage / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D014815:Vitamins; D002762:Cholecalciferol