title: Antihypertensive activity of peptides identified in the in vitro gastrointestinal digest of pork meat.
abstract: This study investigated the in vivo antihypertensive activity of three novel peptides identified in the in vitro digest of pork meat. These peptides were RPR, KAPVA and PTPVP and all of them showed significant antihypertensive activity after oral administration to spontaneously hypertensive rats, RPR being the peptide with the greatest in vivo activity. To our knowledge, this is the first report showing the in vivo antihypertensive action of the three peptides from nebulin (RPR) and titin (KAPVA and PTPVP), thus confirming their reported in vitro angiotensin I-converting enzyme (ACE) inhibitory activity. These findings suggest that pork meat could constitute a source of bioactive constituents that could be utilized in functional foods or nutraceuticals.
authors.affiliation: Instituto de agroquímica y Tecnología de Alimentos (CSIC), Paterna, Valencia, Spain.
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Escudero
authors.forename: Fidel
authors.initials: F
authors.lastname: Toldrá
authors.forename: Miguel Angel
authors.initials: MA
authors.lastname: Sentandreu
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Nishimura
authors.forename: Keizo
authors.initials: K
authors.lastname: Arihara
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D064211:Connectin; D004044:Dietary Proteins / Q000378:metabolism; D004063:Digestion; D006973:Hypertension / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D008460:Meat; D009124:Muscle Proteins / Q000494:pharmacology / Q000627:therapeutic use*; D010455:Peptides / Q000494:pharmacology / Q000627:therapeutic use*; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism; D011494:Protein Kinases / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D011918:Rats, Inbred SHR; D034421:Sus scrofa
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D064211:Connectin; D004044:Dietary Proteins; D009124:Muscle Proteins; D010455:Peptides; C035620:nebulin; D011494:Protein Kinases; D007703:Peptidyl-Dipeptidase A