title: Common variants of the liver fatty acid binding protein gene influence the risk of type 2 diabetes and insulin resistance in Spanish population.
abstract: CONCLUSIONS
  The main objective was to evaluate the association between SNPs and haplotypes of the FABP1-4 genes and type 2 diabetes, as well as its interaction with fat intake, in one general Spanish population. The association was replicated in a second population in which HOMA index was also evaluated.
  
  
  METHODS
  1217 unrelated individuals were selected from a population-based study [Hortega study: 605 women; mean age 54 y; 7.8% with type 2 diabetes]. The replication population included 805 subjects from Segovia, a neighboring region of Spain (446 females; mean age 52 y; 10.3% with type 2 diabetes). DM2 mellitus was defined in a similar way in both studies. Fifteen SNPs previously associated with metabolic traits or with potential influence in the gene expression within the FABP1-4 genes were genotyped with SNPlex and tested. Age, sex and BMI were used as covariates in the logistic regression model.
  
  
  RESULTS
  One polymorphism (rs2197076) and two haplotypes of the FABP-1 showed a strong association with the risk of DM2 in the original population. This association was further confirmed in the second population as well as in the pooled sample. None of the other analyzed variants in FABP2, FABP3 and FABP4 genes were associated. There was not a formal interaction between rs2197076 and fat intake. A significant association between the rs2197076 and the haplotypes of the FABP1 and HOMA-IR was also present in the replication population.
  
  
  CONCLUSIONS
  The study supports the role of common variants of the FABP-1 gene in the development of type 2 diabetes in Caucasians.
authors.affiliation: Genotyping and Genetic Diagnosis Unit, Fundación de Investigación del Hospital Clínico de Valencia-INCLIVA, Valencia, Spain.
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Mansego
authors.forename: Fernando
authors.initials: F
authors.lastname: Martínez
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Martínez-Larrad
authors.forename: Carina
authors.initials: C
authors.lastname: Zabena
authors.forename: Gemma
authors.initials: G
authors.lastname: Rojo
authors.forename: Sonsoles
authors.initials: S
authors.lastname: Morcillo
authors.forename: Federico
authors.initials: F
authors.lastname: Soriguer
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Martín-Escudero
authors.forename: Manuel
authors.initials: M
authors.lastname: Serrano-Ríos
authors.forename: Josep
authors.initials: J
authors.lastname: Redon
authors.forename: Felipe Javier
authors.initials: FJ
authors.lastname: Chaves
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D002318:Cardiovascular Diseases / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000378:metabolism; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins / Q000235:genetics*; D005260:Female; D014644:Genetic Variation; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D012044:Regression Analysis; D012307:Risk Factors; D013030:Spain
chemical_list: C493319:FABP1 protein, human; C493404:FABP2 protein, human; C493408:FABP3 protein, human; C493410:FABP4 protein, human; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins