title: Detection and genotyping of cervical HPV with simultaneous cervical cytology in Turkish women: a hospital-based study.
abstract: OBJECTIVE
  To investigate the prevalence of cervical human papilloma virus (HPV) with genotyping and simultaneous cervical cytology among Turkish women in a university hospital. A review of literature was done as well to summarize the results of similar Turkish studies based on hospital data.
  
  
  METHODS
  Women who were subjected to cervical HPV-DNA testing with simultaneous cervical Pap test were included. Seeplex HPV 18-plex Genotyping Test was used for HPV detection and typing. Liquid-based cytology was used for Pap test and Bethesda system was used for results.
  
  
  RESULTS
  Study group included 890 patients with a mean age of 39.5 years. The prevalence of any HPV was 25.7% while high-risk HPV was positive in 23.0%. There were no significant differences in HPV prevalence between younger and older women. Among HPV-positive women, 89.5% had at least one type of high-risk HPV. Most common HPV was type 16 followed by type 31 and 51. Abnormal cervical cytology rate was 11.6%. Rate of HPV positivity was significantly higher in women with abnormal cervical cytology compared to women with normal cytology (54.4 vs. 22.0%).
  
  
  CONCLUSIONS
  Cervical HPV infection is a serious and gradually growing problem for Turkish women according to hospital-based data. This may be associated with low age at marriage and more sensitive HPV detection methods.
authors.affiliation: Department of Obstetrics and Gynecology, Hacettepe University, Ankara, Turkey.
authors.forename: Kunter
authors.initials: K
authors.lastname: Yuce
authors.forename: Ahmet
authors.initials: A
authors.lastname: Pinar
authors.forename: Mehmet Coskun
authors.initials: MC
authors.lastname: Salman
authors.forename: Alpaslan
authors.initials: A
authors.lastname: Alp
authors.forename: Berkan
authors.initials: B
authors.lastname: Sayal
authors.forename: Selen
authors.initials: S
authors.lastname: Dogan
authors.forename: Gulsen
authors.initials: G
authors.lastname: Hascelik
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D002584:Cervix Uteri / Q000473:pathology*; D005260:Female; D005838:Genotype; D006785:Hospitals, University; D052162:Human papillomavirus 16 / Q000235:genetics / Q000302:isolation & purification; D058952:Human papillomavirus 31 / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae / Q000235:genetics* / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000821:virology*; D015995:Prevalence; D012189:Retrospective Studies; D014421:Turkey / Q000453:epidemiology; D014626:Vaginal Smears; D055815:Young Adult