title: Clinical significance of antibodies to Ro52/TRIM21 in systemic sclerosis.
abstract: BACKGROUND
  Autoantibodies to Ro52 recently identified as TRIM21 are among the most common autoantibodies in systemic autoimmune rheumatic diseases, but their clinical association remains poorly understood. We undertook this study to determine the clinical and serologic associations of anti-Ro52/TRIM21 antibodies in patients with systemic sclerosis (SSc).
  
  
  METHODS
  Detailed clinical data and sera from 963 patients with SSc enrolled in a multicenter cohort study were collected and entered into a central database. Antibodies to Ro52/TRIM21 and other autoantibodies were detected with an addressable laser-bead immunoassay and different enzyme-linked immunosorbent assay (ELISA) systems. Associations between anti-Ro52/TRIM21 antibodies and clinical and other serologic manifestations of SSc were investigated.
  
  
  RESULTS
  Anti-Ro52/TRIM21 antibodies were present in 20% of SSc patients and overlapped with other main SSc-related antibodies, including anti-centromere (by immunofluorescence and centromere protein (CENP)-A and CENP-B ELISA), anti-topoisomerase I, anti-RNA polymerase III, and anti-Pm/Scl antibodies. Anti-Ro52/TRIM21 antibodies were strongly associated with interstitial lung disease (odds ratio (OR), 1.53; 95% confidence interval (CI), 1.11 to 2.12; P = 0.0091) and overlap syndrome (OR, 2.06; 95% CI, 1.01 to 4.19; P = 0.0059).
  
  
  CONCLUSIONS
  Anti-Ro52/TRIM21 antibodies were the second most common autoantibodies in this SSc cohort. In SSc, anti-Ro52/TRIM21 antibodies may be a marker of interstitial lung disease and overlap syndrome.
authors.affiliation: Division of Rheumatology, Jewish General Hospital, 3755 Cote Ste Catherine, Montréal H3T 1E3, Quebec, Canada. marie.hudson@mcgill.ca
authors.forename: Marie
authors.initials: M
authors.lastname: Hudson
authors.forename: Janet
authors.initials: J
authors.lastname: Pope
authors.forename: Michael
authors.initials: M
authors.lastname: Mahler
authors.forename: Solène
authors.initials: S
authors.lastname: Tatibouet
authors.forename: Russell
authors.initials: R
authors.lastname: Steele
authors.forename: Murray
authors.initials: M
authors.lastname: Baron
authors.forename: Marvin J
authors.initials: MJ
authors.lastname: Fritzler
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000096:biosynthesis* / Q000097:blood; D015415:Biomarkers / Q000097:blood; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012261:Ribonucleoproteins / Q000276:immunology*; D012595:Scleroderma, Systemic / Q000175:diagnosis* / Q000276:immunology* / Q000378:metabolism; D000099207:SS-A Antigen
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D012261:Ribonucleoproteins; D000099207:SS-A Antigen