title: Evaluation of DNA binding, antioxidant and cytotoxic activity of mononuclear Co(III) complexes of 2-oxo-1,2-dihydrobenzo[h]quinoline-3-carbaldehyde thiosemicarbazones.
abstract: Four new 2-oxo-1,2-dihydrobenzo[h]quinoline-3-carbaldehyde N-substituted thiosemicarbazone ligands (H(2)-LR, where R = H, Me, Et or Ph) and their corresponding new cobalt(III) complexes have been synthesized and characterized. The structures of the complexes 2 and 3 were determined by single crystal X-ray diffraction analysis. The interactions of the new complexes with DNA were investigated by absorption, emission and viscosity studies which indicated that the complexes bind to DNA via intercalation. Antioxidant studies of the new complexes showed that the significant antioxidant activity against DPPH radical. In addition, the in vitro cytotoxicity of complexes 1-4 against A549 cell line was assayed which showed higher cytotoxic activity with lower IC(50) values indicating their efficiency in killing the cancer cells even at very low concentrations.
authors.affiliation: Department of Chemistry, Bharathiar University, Coimbatore 641046, India.
authors.forename: Eswaran
authors.initials: E
authors.lastname: Ramachandran
authors.forename: Sajesh P
authors.initials: SP
authors.lastname: Thomas
authors.forename: Paramasivan
authors.initials: P
authors.lastname: Poornima
authors.forename: Palaniappan
authors.initials: P
authors.lastname: Kalaivani
authors.forename: Rathinasabapathi
authors.initials: R
authors.lastname: Prabhakaran
authors.forename: Viswanadha Vijaya
authors.initials: VV
authors.lastname: Padma
authors.forename: Karuppannan
authors.initials: K
authors.lastname: Natarajan
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology*; D001667:Binding, Competitive; D001713:Biphenyl Compounds / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D003035:Cobalt / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004247:DNA / Q000378:metabolism*; D004996:Ethidium / Q000378:metabolism; D005290:Ferric Compounds / Q000737:chemistry; D006801:Humans; D007202:Indicators and Reagents / Q000494:pharmacology; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008175:Lung Neoplasms / Q000188:drug therapy / Q000378:metabolism; D008958:Models, Molecular; D015394:Molecular Structure; D009569:Nitric Oxide / Q000378:metabolism; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000494:pharmacology; D010851:Picrates / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013882:Thiosemicarbazones / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D001713:Biphenyl Compounds; D005290:Ferric Compounds; D007202:Indicators and Reagents; D009942:Organometallic Compounds; D010851:Picrates; D013882:Thiosemicarbazones; D009569:Nitric Oxide; D003035:Cobalt; D004247:DNA; C427203:calf thymus DNA; C004931:1,1-diphenyl-2-picrylhydrazyl; D007770:L-Lactate Dehydrogenase; D004996:Ethidium