title: Palladium-catalyzed S-benzylation of unprotected mercaptobenzoic acid with benzyl alcohols in water.
abstract: Palladium-catalyzed S-benzylation of unprotected mercaptobenzoic acids with benzyl alcohols gave only S-benzylated mercaptobenzoic acids in good yields. Water may play an important role for the smooth generation of the (η(3)-benzyl)palladium species by activation of the hydroxyl group of the benzyl alcohol.
authors.affiliation: Faculty of Pharmaceutical Sciences, Toho University, 2-2-1 Miyama, Funabashi, Chiba 274-8510, Japan. hidemasa.hikawa@phar.toho-u.ac.jp
authors.forename: Hidemasa
authors.initials: H
authors.lastname: Hikawa
authors.forename: Yuusaku
authors.initials: Y
authors.lastname: Yokoyama
mesh_terms: D001565:Benzoates / Q000737:chemistry*; D001592:Benzyl Alcohols / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry; D013237:Stereoisomerism; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D014867:Water / Q000737:chemistry*
chemical_list: D001565:Benzoates; D001592:Benzyl Alcohols; D013438:Sulfhydryl Compounds; D014867:Water; C013594:4-mercaptobenzoate; D010165:Palladium