title: [Intraoperative imaging using fluorescence].
abstract: Intraoperative imaging using fluorescence is an experimental technique by which specific tissue structures can be visualised. A preoperatively administered optical contrast agent with fluorescence properties is detected during the operation using a light-sensitive camera system. Using this technique, vital anatomical structures such as blood vessels, bile ducts and ureters are rendered visible to the surgeon. The technique can also serve as a detection method for sentinel lymph nodes. Furthermore, tumour-specific fluorescent tracers are being developed to delineate tumours from surrounding tissue. The aim of this is to increase the number of radical cancer operations and reduce iatrogenic tissue damage. Currently, clinical studies are being conducted to investigate the value and feasibility of this technique for different surgical specialties.
authors.affiliation: Leids Universitair Medisch Centrum, afd. Heelkunde, Leiden, the Netherlands. r.j.swijnenburg@lumc.nl
authors.forename: Rutger-Jan
authors.initials: RJ
authors.lastname: Swijnenburg
authors.forename: Lucia M A
authors.initials: LM
authors.lastname: Crane
authors.forename: K Tim
authors.initials: KT
authors.lastname: Buddingh
authors.forename: Cornelis J H
authors.initials: CJ
authors.lastname: van de Velde
authors.forename: Alexander L
authors.initials: AL
authors.lastname: Vahrmeijer
authors.forename: Gooitzen M
authors.initials: GM
authors.lastname: van Dam
mesh_terms: D003287:Contrast Media / Q000008:administration & dosage*; D003952:Diagnostic Imaging / Q000295:instrumentation / Q000379:methods*; D005456:Fluorescent Dyes / Q000008:administration & dosage*; D006801:Humans; D007432:Intraoperative Period; D008198:Lymph Nodes / Q000473:pathology / Q000601:surgery; D016343:Monitoring, Intraoperative; D009369:Neoplasms / Q000473:pathology / Q000601:surgery
chemical_list: D003287:Contrast Media; D005456:Fluorescent Dyes