title: Genetic support and diversity of acquired extended-spectrum β-lactamases in Gram-negative rods.
abstract: Genes encoding extended-spectrum β-lactamases (ESBLs) have been reported in a variety of Gram-negative species, mostly in Enterobacteriaceae, Pseudomonas aeruginosa and Acinetobacter baumannii. They are either TEM- or SHV-derivatives, CTX-M-like enzymes and less frequently of the GES, PER, or VEB types. The mechanisms at the origin of their acquisition are diverse, and mostly are related to insertion sequences, transposons and class 1 integrons. This diversity of genetic vehicles at the origin of these mobilization/acquisition processes may explain spread of ESBLs worldwide.
authors.affiliation: Service de Bactériologie-Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine et Université Paris-Sud, K. Bicêtre, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Poirel
authors.forename: Rémy A
authors.initials: RA
authors.lastname: Bonnin
authors.forename: Patrice
authors.initials: P
authors.lastname: Nordmann
mesh_terms: D004251:DNA Transposable Elements; D006090:Gram-Negative Bacteria / Q000201:enzymology* / Q000235:genetics*; D032023:Integrons; D010802:Phylogeny; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D004251:DNA Transposable Elements; D001618:beta-Lactamases