title: Anti-TNF therapy induced immune neutropenia in Crohns disease- report of 2 cases and review of literature.
abstract: Transient neutropenia is reported in some patients on biologic therapy. We report two cases of severe neutropenia in patients with Crohn`s disease following treatment with anti-TNF therapy. In both cases neutrophil specific granulocyte autoantibodies were detected during period of neutropenia and disappeared on cessation of anti-TNF therapy. These may indicate that anti-TNF agents may produce autoimmune agranulocytosis by triggering production granulocyte autoantibodies. The long term management strategy for patients with anti-TNF therapy induced autoimmune neutropenia is uncertain.
authors.affiliation: Hull and East Yorkshire Hospitals NHS Trust, Hull, United Kingdom. shaji.Sebastian@hey.nhs.uk
authors.forename: Shaji
authors.initials: S
authors.lastname: Sebastian
authors.forename: Katherine
authors.initials: K
authors.lastname: Ashton
authors.forename: Yasmine
authors.initials: Y
authors.lastname: Houston
authors.forename: Tina Mary
authors.initials: TM
authors.lastname: Diggory
authors.forename: Philip
authors.initials: P
authors.lastname: Dore
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000009:adverse effects* / Q000627:therapeutic use; D003424:Crohn Disease / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006801:Humans; D000069285:Infliximab; D009503:Neutropenia / Q000139:chemically induced* / Q000175:diagnosis / Q000276:immunology
chemical_list: D000893:Anti-Inflammatory Agents; D000911:Antibodies, Monoclonal; D000069285:Infliximab