title: Successful oral therapy for severe falciparum malaria: the World Health Organization criteria revisited.
abstract: We report a successful treatment of severe falciparum malaria in a non-immune adult patient with 30% parasitemia treated with the 6-dose oral regimen of artemether plus lumefantrine combination therapy alone. We have also retrospectively searched our tertiary center's database for similar cases and we have found two additional severe malaria cases, resolved uneventfully with oral regimen. These cases might indicate a need to specifically address the definition of severe and complicated malaria in non-immune patients either in designated guidelines or as an explicit addition to the historical World Health Organization criteria.
authors.affiliation: Department of Internal Medicine C, The Chaim Sheba Medical Center, Tel Hashomer, Israel.
authors.forename: Eran
authors.initials: E
authors.lastname: Kopel
authors.forename: Enbal
authors.initials: E
authors.lastname: Marhoom
authors.forename: Yechezkel
authors.initials: Y
authors.lastname: Sidi
authors.forename: Eli
authors.initials: E
authors.lastname: Schwartz
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000962:Antimalarials / Q000008:administration & dosage*; D000077549:Artemether; D037621:Artemisinins / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D004983:Ethanolamines / Q000008:administration & dosage*; D005449:Fluorenes / Q000008:administration & dosage*; D006801:Humans; D000078102:Lumefantrine; D016778:Malaria, Falciparum / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D018512:Parasitemia / Q000188:drug therapy; D012189:Retrospective Studies; D016896:Treatment Outcome; D014944:World Health Organization; D055815:Young Adult
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D004983:Ethanolamines; D005449:Fluorenes; D000077549:Artemether; D000078102:Lumefantrine