title: Synthesizing the tetracyclic core of nanolobatolide.
abstract: A concise synthetic pathway that enables the stereoselective construction of the tetracyclic core of nanolobatolide has been developed by applying a tandem ring-closing metathesis (RCM) reaction of dienynes, a Eu(fod)(3)-catalyzed intermolecular Diels-Alder reaction, and a biomimetic epoxide opening reaction as key steps.
authors.affiliation: Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen 518055, China.
authors.forename: Le
authors.initials: L
authors.lastname: Chang
authors.forename: Hao
authors.initials: H
authors.lastname: Jiang
authors.forename: Junkai
authors.initials: J
authors.lastname: Fu
authors.forename: Bin
authors.initials: B
authors.lastname: Liu
authors.forename: Chuang-chuang
authors.initials: CC
authors.lastname: Li
authors.forename: Zhen
authors.initials: Z
authors.lastname: Yang
mesh_terms: D001952:Bridged-Ring Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D004852:Epoxy Compounds / Q000737:chemistry*; D015394:Molecular Structure; D011083:Polycyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001952:Bridged-Ring Compounds; D004852:Epoxy Compounds; D011083:Polycyclic Compounds; C545969:nanolobatolide