title: Obtaining enriched compounds via a tandem enantioselective reaction and kinetic resolution polishing sequence.
abstract: Herein we describe a tandem method of coupling an enantioselective reaction with a nonenzymatic kinetic resolution to prepare highly enantioenriched compounds. The procedure employs a moderately selective enantioselective reaction on a ketone or aldehyde to form an enriched alcohol followed by a kinetic resolution of the alcohol to generate ee's of >99% in yields greater than what is possible with a kinetic resolution. This method highlights an avenue to quickly acquire highly enriched compounds without developing and optimizing a new methodology.
authors.affiliation: Department of Chemistry and Biochemistry, University of South Carolina, 631 Sumter Street, Columbia, South Carolina 29208, USA.
authors.forename: Maggie I
authors.initials: MI
authors.lastname: Klauck
authors.forename: Sachin G
authors.initials: SG
authors.lastname: Patel
authors.forename: Sheryl L
authors.initials: SL
authors.lastname: Wiskur