title: Extracorporeal photopheresis as a curative treatment strategy in non epidermotropic T-cell lymphoma and large granular lymphocyte leukemia.
abstract: BACKGROUND
  To evaluate the efficacy of extracorporeal photopheresis (ECP) in noncutaneous T-cell lymphoma and large granular lymphocytes leukemia (LGL).
  
  
  METHODS
  We have treated 12 refractory/relapsed patients. Six peripheral T-cell lymphoma (PTCL), one T-lymphoblastic lymphoma and five LGL with blood involvement received six biweekly leukapheresis as induction phase, followed by one course a week for 4 weeks as consolidation and one course of maintenance per month for responders until progression/relapse or disappearance of the peripheral clone.
  
  
  RESULTS
  Six patients responded to phototherapy. Two PTCL and two LGL achieved a complete response (CR) and two other PTCL a partial response. The median duration of CR was 117 months (45-150 months) for these four patients. The peripheral clone followed by flow cytometry decreased in all six responders. Two patients with a complete disappearance of the peripheral clone have not relapsed.
  
  
  CONCLUSIONS
  As for cutaneous T-cell lymphoma, ECP therefore to be efficient for PTCL and LGL. Early decrease and disappearance of the peripheral clone were the indicators of clinical response and nonrelapse, respectively.
authors.affiliation: Department of Haematology, Grenoble University Hospital, Grenoble.
authors.forename: F
authors.initials: F
authors.lastname: Garban
authors.affiliation: Department of Haematology, Grenoble University Hospital, Grenoble.
authors.forename: S
authors.initials: S
authors.lastname: Carras
authors.affiliation: French National Blood Service, Grenoble Site, La Tronche.
authors.forename: P
authors.initials: P
authors.lastname: Drillat
authors.affiliation: Department of Immunology, Biology and Pathology Institute, Grenoble University Hospital, Grenoble; INSERM U823, Joseph Fourier University-Grenoble 1, Albert Bonniot Institute, Faculté de Médecine, La Tronche.
authors.forename: M C
authors.initials: MC
authors.lastname: Jacob
authors.affiliation: Department of Pathology, Biology and Pathology Institute, Grenoble University Hospital, Grenoble.
authors.forename: B
authors.initials: B
authors.lastname: Fabre
authors.affiliation: INSERM U823, Joseph Fourier University-Grenoble 1, Albert Bonniot Institute, Faculté de Médecine, La Tronche; Department of Onco-Hematological Genetic, Tumoral Molecular Genetic, Biology Institute, Grenoble University Hospital, Grenoble.
authors.forename: M
authors.initials: M
authors.lastname: Callanan
authors.affiliation: Department of Haematology, Grenoble University Hospital, Grenoble.
authors.forename: S
authors.initials: S
authors.lastname: Courby
authors.affiliation: French National Blood Service, Grenoble Site, La Tronche.
authors.forename: C
authors.initials: C
authors.lastname: Makowski
authors.affiliation: Department of Haematology, Grenoble University Hospital, Grenoble; UMR CNRS 5525 THEREX, Joseph Fourier University Grenoble-UFR Médecine, La Tronche, France.
authors.forename: J Y
authors.initials: JY
authors.lastname: Cahn
authors.affiliation: Department of Haematology, Grenoble University Hospital, Grenoble; INSERM U823, Joseph Fourier University-Grenoble 1, Albert Bonniot Institute, Faculté de Médecine, La Tronche. Electronic address: RGressin@chu-grenoble.fr.
authors.forename: R
authors.initials: R
authors.lastname: Gressin
mesh_terms: D000328:Adult; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005260:Female; D006801:Humans; D054066:Leukemia, Large Granular Lymphocytic / Q000188:drug therapy*; D016399:Lymphoma, T-Cell / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D017893:Photopheresis; D016896:Treatment Outcome