title: A case of serial nightmares and oneiroid state under paroxetine for senile depression.
abstract: We report on rare side effects of paroxetine. A 67-year-old female patient who had been suffering from prolonged depression for over a year but had not received appropriate treatment was administered 20-mg paroxetine daily. However, the patient required hospital admission after 16 days because of behavioural disturbances and delusions that she was being chased by evil persons from a religious group. The delusions were ultimately confirmed to be serial nightmares and an oneiroid state. The nightmares gradually disappeared following discontinuation of paroxetine. The Adverse Drug Reaction Probability Scale showed a score of 6 (probable). Reports on paroxetine-induced nightmares are rare, and there is a possibility that, in this case, parexetine caused the nightmares in association with depression and assumed underlying brain dysfunction due to ageing.
authors.affiliation: Department of Psychiatry, Jichi Medical University, Shimotsuke-shi, Tochigi Uchiumi Clinic, Kokuho Ipponmatsu Hospital, Ainan-cho, Minamiuwa, Ehime, Japan. kabakun@jichi.ac.jp
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Mina
authors.initials: M
authors.lastname: Yamauchi
mesh_terms: D000368:Aged; D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects*; D003702:Delusions / Q000139:chemically induced* / Q000523:psychology; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004325:Dreams / Q000187:drug effects* / Q000523:psychology; D064420:Drug-Related Side Effects and Adverse Reactions / Q000139:chemically induced / Q000523:psychology; D005260:Female; D006801:Humans; D017374:Paroxetine / Q000009:adverse effects*; D011569:Psychiatric Status Rating Scales
chemical_list: D018687:Antidepressive Agents, Second-Generation; D017374:Paroxetine