title: Successful treatment of eosinophilic pustular folliculitis with topical tacrolimus 0.1 percent ointment.
abstract: Classic eosinophilic pustular folliculitis (EPF), otherwise known as Ofugi disease, is a rare condition commonly treated with topical glucocorticosteroids. If this fails, oral indomethacin is frequently the next line. Because the condition is recurrent, the use of long term steroids may cause side effects such as skin atrophy, hypertrichosis, and dyspigmentation. Topical tacrolimus is an immunosuppressant that is generally used as a steroid-sparing agent in atopic dermatitis. We report a case of classic EPF, which was recurrent over 5 years that had failed topical glucocorticosteroids but was successfully treated with topical tacrolimus 0.1 percent ointment.
authors.affiliation: Department of Dermatology, Changi General Hospital, Singapore.
authors.forename: Shanna Shan-Yi
authors.initials: SS
authors.lastname: Ng
authors.forename: Yong-Kwang
authors.initials: YK
authors.lastname: Tay
mesh_terms: D004802:Eosinophilia / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D005499:Folliculitis / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D007213:Indomethacin / Q000627:therapeutic use; D008875:Middle Aged; D009824:Ointments / Q000627:therapeutic use; D012872:Skin Diseases, Vesiculobullous / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D016559:Tacrolimus / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D009824:Ointments; D016559:Tacrolimus; D007213:Indomethacin