title: A water soluble Cu(I)-NHC for CuAAC ligation of unprotected peptides under open air conditions.
abstract: A reducing agent-free version of CuAAC able to operate under open air conditions is reported. A readily-synthesizable, hydrophilic and highly stable Cu(I)-NHC allows the clean ligations of unprotected peptides comprising sensitive side chains, at millimolar concentrations.
authors.affiliation: Institut de Chimie de Clermont-Ferrand, CNRS UMR 6296, Clermont-Université, 24 Ave des Landais, F-63177 Aubière, France.
authors.forename: Christelle
authors.initials: C
authors.lastname: Gaulier
authors.forename: Audrey
authors.initials: A
authors.lastname: Hospital
authors.forename: Bertrand
authors.initials: B
authors.lastname: Legeret
authors.forename: Agnès F
authors.initials: AF
authors.lastname: Delmas
authors.forename: Vincent
authors.initials: V
authors.lastname: Aucagne
authors.forename: Federico
authors.initials: F
authors.lastname: Cisnetti
authors.forename: Arnaud
authors.initials: A
authors.lastname: Gautier
mesh_terms: D000388:Air; D000480:Alkynes / Q000737:chemistry*; D000595:Amino Acid Sequence; D001386:Azides / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D009842:Oligopeptides / Q000737:chemistry*; D012995:Solubility; D014867:Water / Q000737:chemistry*
chemical_list: D000480:Alkynes; D001386:Azides; D009842:Oligopeptides; D014867:Water; D003300:Copper