title: Immunity induced by Staphylococcus aureus surface protein A was protective against lethal challenge of Staphylococcus aureus in BALB/c mice.
abstract: Staphylococcus aureus is the most common cause of hospital-acquired bacteremia. Due to emergence of antibiotic-resistant strains, these infections present a serious public health threat. In this study, to develop a broadly protective vaccine, we tested whether immune responses induced by several proteins associated with S. aureus toxicity could protect mice from lethal challenge with human clinical S. aureus isolate USA300. We found that the surface protein A (SasA) of S. aureus could protect mice from lethal challenge of the bacteria.
authors.affiliation: State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, 20 Dongdajie, Fengtai, Beijing 100071, China.
authors.forename: Shao-Qiong
authors.initials: SQ
authors.lastname: Yi
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Zhang
authors.forename: Yi-Long
authors.initials: YL
authors.lastname: Yang
authors.forename: Yue
authors.initials: Y
authors.lastname: Yang
authors.forename: Shu-Ling
authors.initials: SL
authors.lastname: Liu
authors.forename: Ling
authors.initials: L
authors.lastname: Fu
authors.forename: Chang-Ming
authors.initials: CM
authors.lastname: Yu
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000008:administration & dosage / Q000276:immunology*; D005260:Female; D008565:Membrane Proteins / Q000008:administration & dosage / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D013203:Staphylococcal Infections / Q000276:immunology / Q000401:mortality / Q000517:prevention & control*; D013209:Staphylococcal Vaccines / Q000008:administration & dosage / Q000276:immunology*; D013211:Staphylococcus aureus / Q000276:immunology* / Q000472:pathogenicity; D016019:Survival Analysis
chemical_list: D001426:Bacterial Proteins; D008565:Membrane Proteins; D013209:Staphylococcal Vaccines