title: Dynamics of a supramolecular capsule assembly with pyrene.
abstract: Water-soluble octaacid cavitands (OAs) form dimeric capsules suitable for guest incorporation. Our studies reveal that the mechanism of pyrene (Py) binding involves the rapid (<1 ms) formation of the Py·OA complex followed by slower binding with the second OA. The dissociation of the capsular OA·Py·OA complex occurs with a lifetime of 2.7 s, which is 5 orders of magnitude slower than the microsecond opening/closing ("breathing") previously observed to provide access of small molecules to the encapsulated guest. These different dynamics of the capsules have a potential impact on how the chemistry of included guests could be altered.
authors.affiliation: Department of Chemistry, University of Victoria, Victoria, BC, Canada.
authors.forename: Hao
authors.initials: H
authors.lastname: Tang
authors.forename: Carla Santos
authors.initials: CS
authors.lastname: de Oliveira
authors.forename: Gage
authors.initials: G
authors.lastname: Sonntag
authors.forename: Corinne L D
authors.initials: CL
authors.lastname: Gibb
authors.forename: Bruce C
authors.initials: BC
authors.lastname: Gibb
authors.forename: Cornelia
authors.initials: C
authors.lastname: Bohne
mesh_terms: D001665:Binding Sites; D002214:Capsules / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D019281:Dimerization; D004988:Ethers, Cyclic / Q000737:chemistry*; D007700:Kinetics; D011721:Pyrenes / Q000737:chemistry*; D012118:Resorcinols / Q000737:chemistry*; D013050:Spectrometry, Fluorescence
chemical_list: D002214:Capsules; D002264:Carboxylic Acids; D004988:Ethers, Cyclic; D011721:Pyrenes; D012118:Resorcinols; C030984:pyrene