title: A third gyrovirus species in human faeces.
abstract: Until 2011 the genus Gyrovirus in the family Circoviridae consisted of a single virus (Chicken anemia virus or CAV) causing a common immunosuppressive disease in chickens when a second gyrovirus (HGyV) was reported on the skin of 4 % of healthy humans. HGyV is very closely related to a recently described chicken gyrovirus, AGV2, suggesting that they belong to the same viral species. During a viral metagenomic analysis of 100 human faeces from children with diarrhoea in Chile we identified multiple known human pathogens (adenoviruses, enteroviruses, astroviruses, sapoviruses, noroviruses, parechoviruses and rotaviruses) and a novel gyrovirus species we named GyV3 sharing <63 % similarity with other gyrovirus proteins with evidence of recombination with CAV in its UTR. Gyroviridae consensus PCR revealed a high prevalence of CAV DNA in diarrhoea and normal faeces from Chilean children and faeces of USA cats and dogs, which may reflect consumption of CAV-infected/vaccinated chickens. Whether GyV3 can infect humans and/or chickens requires further studies.
authors.affiliation: Department of Laboratory Medicine, University of California at San Francisco, San Francisco, CA 94118, USA.|Blood Systems Research Institute, San Francisco, CA 94118, USA.
authors.forename: Tung G
authors.initials: TG
authors.lastname: Phan
authors.affiliation: Department of Laboratory Medicine, University of California at San Francisco, San Francisco, CA 94118, USA.|Blood Systems Research Institute, San Francisco, CA 94118, USA.
authors.forename: Linlin
authors.initials: L
authors.lastname: Li
authors.affiliation: Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile.
authors.forename: Miguel G
authors.initials: MG
authors.lastname: O'Ryan
authors.affiliation: Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile.
authors.forename: Hector
authors.initials: H
authors.lastname: Cortes
authors.affiliation: Institute of Biomedical Sciences, Faculty of Medicine, University of Chile, Santiago, Chile.
authors.forename: Nora
authors.initials: N
authors.lastname: Mamani
authors.affiliation: Laboratoire National de Santé Publique, 09 BP 24, Ouagadougou, Burkina Faso.
authors.forename: Isidore J O
authors.initials: IJO
authors.lastname: Bonkoungou
authors.affiliation: Division of Infectious Diseases, Stanford University Medical Center, Stanford, CA 94305, USA.
authors.forename: Chunling
authors.initials: C
authors.lastname: Wang
authors.affiliation: IDEXX Reference Laboratories, West Sacramento, CA 95605, USA.
authors.forename: Christian M
authors.initials: CM
authors.lastname: Leutenegger
authors.affiliation: Department of Laboratory Medicine, University of California at San Francisco, San Francisco, CA 94118, USA.|Blood Systems Research Institute, San Francisco, CA 94118, USA.
authors.forename: Eric
authors.initials: E
authors.lastname: Delwart
mesh_terms: D000818:Animals; D002415:Cats; D002645:Chickens / Q000821:virology; D002648:Child; D002677:Chile; D018173:Circoviridae Infections / Q000662:veterinary* / Q000821:virology; D004285:Dogs; D005243:Feces / Q000821:virology*; D005506:Food Contamination; D046810:Gyrovirus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D008969:Molecular Sequence Data; D011201:Poultry Diseases / Q000821:virology*