title: Minireview: animal models and mechanisms of ovarian cancer development.
abstract: Ovarian cancer in women is a complex and deadly disease, where the molecular events that initiate and control tumor formation remain poorly defined. Therefore, mouse models provide one approach for determining the mechanisms by which specific oncogenic factors cause ovarian surface epithelial cell and granulosa cell transformation. This minireview summarizes the phenotypes of current mouse models that have been generated and some of the underlying mechanisms they have provided.
authors.affiliation: Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA.
authors.forename: Lisa K
authors.initials: LK
authors.lastname: Mullany
authors.forename: JoAnne S
authors.initials: JS
authors.lastname: Richards
mesh_terms: D000818:Animals; D000077216:Carcinoma, Ovarian Epithelial; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D004195:Disease Models, Animal; D005260:Female; D006106:Granulosa Cell Tumor / Q000473:pathology / Q000503:physiopathology; D051379:Mice; D009375:Neoplasms, Glandular and Epithelial / Q000473:pathology / Q000503:physiopathology; D010051:Ovarian Neoplasms / Q000473:pathology* / Q000503:physiopathology*; D010641:Phenotype; D016159:Tumor Suppressor Protein p53 / Q000502:physiology
chemical_list: D016159:Tumor Suppressor Protein p53