title: 10-Shogaol, an antioxidant from Zingiber officinale for skin cell proliferation and migration enhancer.
abstract: In this work, one of Zingiber officinale components, 10-shogaol, was tested with 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging, metal chelating ability, and reducing power to show antioxidant activity. 10-Shogaol promoted human normal epidermal keratinocytes and dermal fibroblasts cell growths. 10-Shogaol enhanced growth factor production in transforming growth factor-β (TGF-β), platelet derived growth factor-αβ (PDGF-αβ) and vascular endothelial growth factors (VEGF) of both cells. In the in vitro wound healing assay for 12 or 24 h, with 10-shogaol, the fibroblasts and keratinocytes migrated more rapidly than the vehicle control group. Thus, this study substantiates the target compound, 10-shogaol, as an antioxidant for human skin cell growth and a migration enhancer with potential to be a novel wound repair agent.
authors.affiliation: Department of Medical Laboratory Science and Biotechnology, School of Medical and Health Sciences, Fooyin University, 151, Ching-Hsueh Road, Ta-Liao District, Kaohsiung 83102, Taiwan.
authors.forename: Chung-Yi
authors.initials: CY
authors.lastname: Chen
authors.affiliation: Department of Internal Medicine, Chi-Mei Medical Centre, Tainan 710, Taiwan.|Department of Safety Health and Environment, Chung Hwa University of Medical Technology, Tainan 717, Taiwan.|Department of Medicine, National Defense Medical Center, Taipei 114, Taiwan.
authors.forename: Kuo-Chen
authors.initials: KC
authors.lastname: Cheng
authors.affiliation: Department of Biology, University of California, Riverside, Riverside, CA 92521, USA.|Department of Fragrance and Cosmetic Science, Kaohsiung Medical University, 100, Shih-Chuan 1st Road, San-Ming District, Kaohsiung 80708, Taiwan.
authors.forename: Andy Y
authors.initials: AY
authors.lastname: Chang
authors.affiliation: Department of Biotechnology, College of Life Sciences, Kaohsiung Medical University, Kaohsiung 80708, Taiwan.
authors.forename: Ying-Ting
authors.initials: YT
authors.lastname: Lin
authors.affiliation: Department of Cosmeceutics, College of Pharmacy, China Medical University, Taichung 404, Taiwan.
authors.forename: You-Cheng
authors.initials: YC
authors.lastname: Hseu
authors.affiliation: Department of Fragrance and Cosmetic Science, Kaohsiung Medical University, 100, Shih-Chuan 1st Road, San-Ming District, Kaohsiung 80708, Taiwan.
authors.forename: Hui-Min
authors.identifier: 0000-0002-5162-9752
authors.initials: HM
authors.lastname: Wang
mesh_terms: D000975:Antioxidants / Q000302:isolation & purification / Q000494:pharmacology*; D002465:Cell Movement / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects*; D002478:Cells, Cultured; D020939:Zingiber officinale / Q000737:chemistry*; D006139:Guaiacol / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D015603:Keratinocytes / Q000187:drug effects* / Q000502:physiology; D010936:Plant Extracts / Q000494:pharmacology; D012867:Skin / Q000166:cytology / Q000187:drug effects; D015854:Up-Regulation / Q000187:drug effects; D014945:Wound Healing / Q000187:drug effects
chemical_list: D000975:Antioxidants; D010936:Plant Extracts; D006139:Guaiacol; C585130:(10)-shogaol