title: Evaluation of a resorbable collagen matrix infused with rhPDGF-BB in peri-implant soft tissue augmentation: a preliminary report with 3.5 years of observation.
abstract: Soft tissue augmentation around dental implants in the esthetic region remains a challenging and unpredictable procedure. The ideal surgical technique would include of an off-the-shelf product to minimize morbidity after autogenous grafting procedures. The aim of this study was to use a resorbable collagen matrix (Mucograft) to serve as a scaffold to recombinant human platelet-derived growth factor BB (rhPDGF-BB) to increase peri-implant soft tissue volume in anterior maxillary sites. A total of six patients who had previously undergone a bone regeneration procedure were included in this study. The collagen matrix was applied during stage-two surgery (expanded polytetrafluoroethylene membrane removal and implant placement). Measurements were performed through customized stents by means of endodontic files, and at abutment connection, a soft tissue biopsy specimen was harvested for histologic examination. The healing period was uneventful in all six patients. Measurements were taken apically, centrally, and occlusally for each site. The mean gains in volume from baseline to the 4-month measurement at the apical, central, and occlusal aspects were 0.87 ± 2.13 mm, 2.14 ± 3.27 mm, and 0.35 ± 3.20 mm, respectively. The results showed a moderate increase in the soft tissue volume in esthetic peri-implant sites when applying a collagen matrix infused with rhPDGF-BB. However, the measuring techniques available need to be further improved to record exact changes in the soft tissue volume.
authors.affiliation: Department of Periodontology, Universitá degli studi di Milano, Milan, Italy. msimion@studiosimion.it
authors.forename: Massimo
authors.initials: M
authors.lastname: Simion
authors.forename: Isabella
authors.initials: I
authors.lastname: Rocchietta
authors.forename: Filippo
authors.initials: F
authors.lastname: Fontana
authors.forename: Claudia
authors.initials: C
authors.lastname: Dellavia
mesh_terms: D020341:Absorbable Implants; D043925:Angiogenesis Inducing Agents / Q000627:therapeutic use*; D000077214:Becaplermin; D001706:Biopsy; D001861:Bone Regeneration / Q000502:physiology; D003094:Collagen; D059605:Dental Implant-Abutment Design; D003758:Dental Implantation, Endosseous; D004955:Esthetics, Dental; D005500:Follow-Up Studies; D005881:Gingiva / Q000187:drug effects / Q000473:pathology; D005893:Gingivoplasty / Q000379:methods*; D006801:Humans; D008437:Maxilla / Q000473:pathology / Q000601:surgery; D008567:Membranes, Artificial; D011138:Polytetrafluoroethylene; D020574:Proto-Oncogene Proteins c-sis / Q000627:therapeutic use*; D011994:Recombinant Proteins; D013524:Surgical Flaps; D054457:Tissue Scaffolds; D016896:Treatment Outcome
chemical_list: D043925:Angiogenesis Inducing Agents; D008567:Membranes, Artificial; D020574:Proto-Oncogene Proteins c-sis; D011994:Recombinant Proteins; D000077214:Becaplermin; D011138:Polytetrafluoroethylene; D003094:Collagen