title: Ob-stopping obesity, metabolic and immune-mediated disorders.
abstract: Despite its physiological importance, no part of human leptin receptor (ObR) has been structurally characterized before. In this issue of Structure, Carpenter et al. report the crystal structure of the leptin-binding domain of human ObR in complex with the Fab fragment of an ObR-blocking monoclonal antibody (9F8 mAb).
authors.affiliation: Laboratorio di Immunologia, Istituto di Endocrinologia e Oncologia Sperimentale, Consiglio Nazionale delle Ricerche, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Universitá di Napoli Federico II, Napoli 80131, Italy. gmatarese@unisa.it
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Matarese
authors.forename: Veronica
authors.initials: V
authors.lastname: De Rosa