title: Association of ACE I/D gene polymorphism with vesicoureteral reflux susceptibility in children: a meta-analysis.
abstract: OBJECTIVE
  Many studies have been conducted to investigate the association between angiotensin-converting enzyme (ACE) insertion (I)/deletion (D) gene polymorphism and vesicoureteral reflux (VUR) susceptibility. However, the results from those studies are still conflicting. We performed a meta-analysis of studies relating the ACE I/D gene polymorphism to the risk of VUR.
  
  
  METHODS
  We searched the databases of PubMed, Embase, Cochrane Library and CBM-disc (China Biological Medicine Database) as of 1 March 2011, and recruited the eligible investigations for this meta-analysis.
  
  
  RESULTS
  Ten investigations were identified for the analysis of association between ACE I/D gene polymorphism and VUR risk: six in Caucasians, three in East-Asians and one in a Turkish population. All the investigations were performed in children. There was no marked association between ACE I/D gene polymorphism and VUR susceptibility/renal scar for overall populations, Caucasians and East-Asians. In the Turkish population, D allele and DD genotype were associated with the VUR susceptibility/renal scar. Furthermore, ACE I/D gene polymorphism was not associated with VUR progression.
  
  
  CONCLUSIONS
  D allele and DD genotype are risk factors for the VUR susceptibility/renal scar in Turkish children. However, more case-control association investigations on larger, stratified populations are required in the future.
authors.affiliation: Department of Pediatrics, The First Affiliated Hospital of GuangXi Medical University, NanNing, China. a126tianbiao@126.com
authors.forename: Tian-Biao
authors.initials: TB
authors.lastname: Zhou
authors.forename: Na
authors.initials: N
authors.lastname: Lin
authors.forename: Yun-Guang
authors.initials: YG
authors.lastname: Liu
authors.forename: Yuan-Han
authors.initials: YH
authors.lastname: Qin
authors.forename: Ming-Bin
authors.initials: MB
authors.lastname: Shao
authors.forename: Dan-Dan
authors.initials: DD
authors.lastname: Peng
mesh_terms: D044466:Asian People / Q000235:genetics; D002648:Child; D002921:Cicatrix / Q000150:complications / Q000473:pathology; D018450:Disease Progression; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D054643:INDEL Mutation / Q000235:genetics*; D007668:Kidney / Q000473:pathology; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D017594:Publication Bias; D012307:Risk Factors; D014718:Vesico-Ureteral Reflux / Q000150:complications / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: C488034:ACE protein, human; D007703:Peptidyl-Dipeptidase A