title: The relationship between diabetes, metabolic syndrome, and platelet activity as measured by mean platelet volume: the National Health And Nutrition Examination Survey, 1999-2004.
abstract: OBJECTIVE
  The association between platelet activity, diabetes, and glucometabolic control is uncertain. We aim to investigate mean platelet volume (MPV), a marker of platelet size and platelet activity, with the prevalence of diabetes, metabolic syndrome, and degree of glycemic control.
  
  
  METHODS
  This is a retrospective analysis of 13,021 participants in the National Health and Nutrition Examination Survey from 1999 to 2004. Prevalence of diabetes was defined as nonfasting glucose >200 mg/dL, fasting glucose ≥ 126 mg/dL, or treatment with hypoglycemic agents. Presence of metabolic syndrome was determined by the National Cholesterol Education Program Adult Treatment Panel III definition. Odds ratios and 95% CIs were estimated by logistic regression.
  
  
  RESULTS
  MPV was significantly higher in subjects with diabetes (8.20 vs. 8.06 femtoliter [fL], P < 0.01) but not in subjects with metabolic syndrome (8.09 vs. 8.07 fL, P = 0.24). For the metabolic syndrome components, MPV was significantly higher in abdominal obesity (P = 0.03) and low HDL (P = 0.04), and not different in high blood pressure (P = 0.07), abnormal glucose metabolism (P = 0.71), or hypertriglyceridemia (P = 0.46). There was a significant correlation between MPV and glucose (P < 0.0001) and between MPV and hemoglobin A(1c) (P < 0.0001) in subjects with diabetes. These correlations were no longer significant in those without diabetes. The adjusted odds of diabetes rose with increasing MPV levels and were most pronounced in subjects with MPV levels exceeding the 90th percentile (≥ 9.31 fL). The association between MPV and diabetes was most apparent in those with the poorest glucose control.
  
  
  CONCLUSIONS
  Mean platelet volume is strongly and independently associated with the presence and severity of diabetes.
authors.affiliation: Department of Medicine, Division of Cardiology, New York University, School of Medicine, New York, New York, USA.
authors.forename: Binita
authors.initials: B
authors.lastname: Shah
authors.forename: Daohang
authors.initials: D
authors.lastname: Sha
authors.forename: Dawei
authors.initials: D
authors.lastname: Xie
authors.forename: Emile R
authors.initials: ER
authors.lastname: Mohler
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Berger
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001786:Blood Glucose / Q000378:metabolism; D003920:Diabetes Mellitus / Q000097:blood* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000453:epidemiology*; D008875:Middle Aged; D015539:Platelet Activation / Q000502:physiology*; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D001786:Blood Glucose