title: [Different sensitivity to chemotherapy between adenocarcinoma and adenosquamous carcinoma in a case of synchronous multicentric gastric cancer].
abstract: A 60-year-old man presented with upper gastrointestinal bleeding. We diagnosed double gastric cancer (adenocarcinoma and adenosquamous carcinoma) based on an endoscopic examination. Due to uncontrollable bleeding, total gastrectomy was performed after 4 courses of chemotherapy with S-1+cisplatin. Histological investigation revealed that no obvious anti-cancer effect was observed in adenosquamous carcinoma (Grade 1), while tumor cells were eliminated in the area of adenocarcinoma (Grade 3). This case clearly demonstrated that sensitivity to chemotherapy was different between adenocarcinoma and adenosquamous carcinoma of the stomach.
authors.affiliation: Department of Gastroenterology, Kainan Hospital, Japan.
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Watanabe
authors.forename: Koichi
authors.initials: K
authors.lastname: Achiwa
authors.forename: Hisanori
authors.initials: H
authors.lastname: Muto
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Arakawa
authors.forename: Kota
authors.initials: K
authors.lastname: Aoki
authors.forename: Minoru
authors.initials: M
authors.lastname: Kubota
authors.forename: Daisuke
authors.initials: D
authors.lastname: Ishikawa
authors.forename: Shin
authors.initials: S
authors.lastname: Kunii
authors.forename: Keisuke
authors.initials: K
authors.lastname: Goto
authors.forename: Akihiko
authors.initials: A
authors.lastname: Okumura
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology; D018196:Carcinoma, Adenosquamous / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000188:drug therapy* / Q000473:pathology; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology