title: CMOS image sensor integrated with micro-LED and multielectrode arrays for the patterned photostimulation and multichannel recording of neuronal tissue.
abstract: We developed a complementary metal oxide semiconductor (CMOS) integrated device for optogenetic applications. This device can interface via neuronal tissue with three functional modalities: imaging, optical stimulation and electrical recording. The CMOS image sensor was fabricated on 0.35 μm standard CMOS process with built-in control circuits for an on-chip blue light-emitting diode (LED) array. The effective imaging area was 2.0 × 1.8 mm². The pixel array was composed of 7.5 × 7.5 μm² 3-transistor active pixel sensors (APSs). The LED array had 10 × 8 micro-LEDs measuring 192 × 225 μm². We integrated the device with a commercial multichannel recording system to make electrical recordings.
authors.affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0192, Japan.
authors.forename: Arata
authors.initials: A
authors.lastname: Nakajima
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kimura
authors.forename: Yosmongkol
authors.initials: Y
authors.lastname: Sawadsaringkarn
authors.forename: Yasuyo
authors.initials: Y
authors.lastname: Maezawa
authors.forename: Takuma
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Noda
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Sasagawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Tokuda
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Ishikawa
authors.forename: Sadao
authors.initials: S
authors.lastname: Shiosaka
authors.forename: Jun
authors.initials: J
authors.lastname: Ohta
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D004558:Electric Stimulation / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D008029:Lighting / Q000295:instrumentation*; D008839:Microelectrodes; D008853:Microscopy / Q000295:instrumentation*; D008904:Miniaturization; D009474:Neurons / Q000502:physiology*; D010775:Photic Stimulation / Q000295:instrumentation*; D012666:Semiconductors; D018511:Systems Integration