title: Complex regulation of an R gene SNC1 revealed by auto-immune mutants.
abstract: Plants have evolved resistance (R) proteins to detect pathogen effectors and trigger plant defense responses in the so named effector-triggered immunity (ETI). R proteins are under negative regulation in plants as upregulated activation of R protein is detrimental to plant growth. Autoimmune mutants have been instrumental in understanding the fine tuning of plant defense responses. Recently, a number of such mutants have been molecularly characterized, and some of them result from over-activation of SNC1, a TIR-NBS-LRR type of R protein. Studies of these mutants revealed a complex negative regulation of SNC1 activity from transcriptional to post-translational regulation. Here, we summarize studies on these SNC1-dependent auto-immune mutants and discuss the fine regulation of R proteins in plant immunity.
authors.affiliation: Department of Plant Biology, Cornell University, Ithaca, NY, USA.
authors.forename: Mingyue
authors.initials: M
authors.lastname: Gou
authors.forename: Jian
authors.initials: J
authors.lastname: Hua
mesh_terms: D017360:Arabidopsis / Q000235:genetics* / Q000382:microbiology; D029681:Arabidopsis Proteins / Q000235:genetics*; D018506:Gene Expression Regulation, Plant; D017343:Genes, Plant; D009154:Mutation; D010935:Plant Diseases / Q000235:genetics* / Q000382:microbiology; D057865:Plant Immunity / Q000235:genetics*; D011499:Protein Processing, Post-Translational; D014158:Transcription, Genetic
chemical_list: D029681:Arabidopsis Proteins; C482739:SNC1 protein, Arabidopsis