title: The mammalian synaptonemal complex: protein components, assembly and role in meiotic recombination.
abstract: The synaptonemal complex (SC) is a proteinaceous structure of chromosome bivalents whose assembly is indispensable for the successful progression of the first meiotic division of sexually reproducing organisms. In this mini-review we will focus on recent progress dealing with the composition and assembly of the mammalian SC. These advances mainly resulted from the systematic use of knockout mice for all known mammalian SC proteins as well as from protein polymerization studies performed in heterologous systems.
authors.affiliation: Department of Cell and Developmental Biology, Biocenter, University of Würzburg, D-97074 Würzburg, Germany.
authors.forename: Johanna
authors.initials: J
authors.lastname: Fraune
authors.forename: Sabine
authors.initials: S
authors.lastname: Schramm
authors.forename: Manfred
authors.initials: M
authors.lastname: Alsheimer
authors.forename: Ricardo
authors.initials: R
authors.lastname: Benavente
mesh_terms: D000818:Animals; D006801:Humans; D008322:Mammals / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D008540:Meiosis / Q000235:genetics / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D008954:Models, Biological; D055503:Protein Multimerization / Q000235:genetics / Q000502:physiology*; D021122:Protein Subunits / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D011995:Recombination, Genetic / Q000235:genetics / Q000502:physiology*; D013573:Synaptonemal Complex / Q000235:genetics / Q000378:metabolism / Q000502:physiology*
chemical_list: D021122:Protein Subunits