title: Continuous-flow catalytic asymmetric hydrogenations: Reaction optimization using FTIR inline analysis.
abstract: The asymmetric organocatalytic hydrogenation of benzoxazines, quinolines, quinoxalines and 3H-indoles in continuous-flow microreactors has been developed. Reaction monitoring was achieved by using an inline ReactIR flow cell, which allows fast and convenient optimization of reaction parameters. The reductions proceeded well, and the desired products were isolated in high yields and with excellent enantioselectivities.
authors.affiliation: Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, D-52074 Aachen, Germany.
authors.forename: Magnus
authors.initials: M
authors.lastname: Rueping
authors.forename: Teerawut
authors.initials: T
authors.lastname: Bootwicha
authors.forename: Erli
authors.initials: E
authors.lastname: Sugiono