title: Ring enlargement versus selenoetherification on the reaction of allenyl oxindoles with selenenylating reagents.
abstract: Lactam-tethered allenols, readily prepared from α-oxolactams, were used as starting materials for divergent reactivity with selenenylating reagents. Either oxycyclization (spirocyclic selenolactams) or ring expansion (selenoquinolones) can be achieved through the choice of both reagents and substrates. The biological activity of some of the synthesized heterocycles has additionally been evaluated in four human cancer cell lines.
authors.affiliation: Grupo de Lactamas y Heterociclos Bioactivos, Departamento de Química Orgánica I, Unidad Asociada al CSIC, Facultad de Química, Universidad Complutense de Madrid, 28040-Madrid, Spain. alcaideb@quim.ucm.es
authors.forename: Benito
authors.initials: B
authors.lastname: Alcaide
authors.forename: Pedro
authors.initials: P
authors.lastname: Almendros
authors.forename: Amparo
authors.initials: A
authors.lastname: Luna
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Gómez-Campillos
authors.forename: M Rosario
authors.initials: MR
authors.lastname: Torres
mesh_terms: D000466:Alkadienes / Q000737:chemistry*; D002384:Catalysis; D006801:Humans; D007202:Indicators and Reagents / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D007769:Lactams / Q000737:chemistry*; D015394:Molecular Structure; D000078183:Oxindoles; D018036:Selenium Compounds / Q000737:chemistry*
chemical_list: D000466:Alkadienes; D007202:Indicators and Reagents; D007211:Indoles; D007769:Lactams; D000078183:Oxindoles; D018036:Selenium Compounds; C022960:2-oxindole