title: [Epidemiology and physiopathogy of Sjögren's syndrome].
abstract: Sjögren's syndrome is defined as an autoimmune disease characterized by a progressive sicca syndrome associated with anti-SSA or SSA positivity and/or significant infiltrate at minor salivary gland biopsy. This autoimmune disease is relatively frequent, with a clinical diagnosis among women after the 5 decade. Its physiopathology, complex, associates the intervention of both environmental and genetic factors. Salivary epithelial cell is at the center of the pathological immune response of primary Sjögren's syndrome, characterized by a chronic B cell polyclonal activation potentially leading to the development of B cell lymphoma.
authors.affiliation: Service de médecine interne A, CHU de Limoges, hôpital Dupuytren, 87042 Limoges. anne-laure.fauchais@chu-limoges.fr
authors.forename: Anne-Laure
authors.initials: AL
authors.lastname: Fauchais
authors.forename: Clothilde
authors.initials: C
authors.lastname: Martel
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Vidal
mesh_terms: D001323:Autoantibodies / Q000009:adverse effects; D005260:Female; D006801:Humans; D007372:Interferons / Q000502:physiology; D008214:Lymphocytes / Q000502:physiology; D008297:Male; D008954:Models, Biological; D012859:Sjogren's Syndrome / Q000453:epidemiology* / Q000209:etiology* / Q000235:genetics; D051193:Toll-Like Receptors / Q000502:physiology; D014777:Virus Diseases / Q000150:complications
chemical_list: D001323:Autoantibodies; D051193:Toll-Like Receptors; D007372:Interferons