title: A 1,3-phenyl-linked hydantoin oligomer scaffold as a β-strand mimetic.
abstract: A synthetic scaffold that mimics a peptide β-strand has been designed and synthesised based on a 1,3-phenyl-linked hydantoin oligomer. The conformational preferences of this oligomer were investigated using molecular modelling and solution NMR experiments and suggest a planar conformation that accurately mimics the i, i + 2 and i + 4 residues of a peptide β-strand.
authors.affiliation: Department of Chemistry, University of Leicester, Leicester, LE1 7RH, UK. andrew.jamieson@le.ac.uk
authors.forename: Andrew G
authors.initials: AG
authors.lastname: Jamieson
authors.forename: David
authors.initials: D
authors.lastname: Russell
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Hamilton
mesh_terms: D032701:Biomimetics; D006827:Hydantoins / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D010446:Peptide Fragments / Q000737:chemistry; D017433:Protein Structure, Secondary
chemical_list: D006827:Hydantoins; D010446:Peptide Fragments