title: Evaluation of traditional Chinese medicinal plants for anti-MRSA activity with reference to the treatment record of infectious diseases.
abstract: The in vitro antimicrobial activities of 30 Chinese medicinal plants were evaluated with reference to the treatment record of infectious diseases in the Traditional Chinese Medicine (TCM) literature. The plant materials were extracted with 80% ethanol and the extracts were primarily screened against conventional clinical pathogens like Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa and Candida albicans by the agar diffusion method. Their inhibition zone diameters (IZDs, mm, 50 mg/mL) ranged from 2,048 by the standard broth microdilution method. The seven extracts from M. yunnanensis, S. sinensis, G. morella, E. daneillii, M. squamulata, S. arborescens and B. hancei were determined as the most active extracts, with MICs of 8-64 μg/mL. The results were in good agreement with their traditional applications in skin and other infections.
authors.affiliation: Research Center for Natural Medicines, Kunming General Hospital, PLA, Kunming 650032, China. zuoguoying@263.net
authors.forename: Guo-Ying
authors.initials: GY
authors.lastname: Zuo
authors.forename: Xin-Juan
authors.initials: XJ
authors.lastname: Zhang
authors.forename: Cui-Xian
authors.initials: CX
authors.lastname: Yang
authors.forename: Jun
authors.initials: J
authors.lastname: Han
authors.forename: Gen-Chun
authors.initials: GC
authors.lastname: Wang
authors.forename: Zhong-Qi
authors.initials: ZQ
authors.lastname: Bian
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D003141:Communicable Diseases; D052978:Disk Diffusion Antimicrobial Tests; D004353:Drug Evaluation, Preclinical; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects; D006801:Humans; D008516:Medicine, Chinese Traditional; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D004365:Drugs, Chinese Herbal