title: Assessing interactions for fixed-dose drug combinations in tumor xenograft studies.
abstract: Statistical methods for assessing the joint action of compounds administered in combination have been established for many years. However, there is little literature available on assessing the joint action of fixed-dose drug combinations in tumor xenograft experiments. Here an interaction index for fixed-dose two-drug combinations is proposed. Furthermore, a regression analysis is also discussed. Actual tumor xenograft data were analyzed to illustrate the proposed methods.
authors.affiliation: Department of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Jianrong.Wu@stjude.org
authors.forename: Jianrong
authors.initials: J
authors.lastname: Wu
authors.forename: Lorraine
authors.initials: L
authors.lastname: Tracey
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Davidoff
mesh_terms: D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000378:metabolism*; D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004347:Drug Interactions / Q000502:physiology*; D004357:Drug Synergism; D006801:Humans; D051379:Mice; D023041:Xenograft Model Antitumor Assays / Q000379:methods / Q000706:statistics & numerical data*
chemical_list: D004338:Drug Combinations