title: Phosphonium lipocations as antiparasitic agents.
abstract: Phosphonium lipocations were synthesized and evaluated for inhibition of the development of Plasmodium falciparum and Trypanosoma cruzi, etiological agents of malaria and Chagas disease, respectively. Optimal phthalimides and 1,4-naphthoquinone-based lipocations were active in vitro at mid-high nM concentrations against P. falciparum and low μM concentrations against T. cruzi.
authors.affiliation: Department of Pharmaceutical and Biomedical Sciences and Center for Drug Discovery, University of Georgia, Athens, GA 30602, USA. tlong@rx.uga.edu
authors.forename: Timothy E
authors.initials: TE
authors.lastname: Long
authors.forename: Xiao
authors.initials: X
authors.lastname: Lu
authors.forename: Melina
authors.initials: M
authors.lastname: Galizzi
authors.forename: Roberto
authors.initials: R
authors.lastname: Docampo
authors.forename: Jiri
authors.initials: J
authors.lastname: Gut
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Rosenthal
mesh_terms: D000818:Animals; D000977:Antiparasitic Agents / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology*; D002412:Cations; D014355:Chagas Disease / Q000188:drug therapy; D002522:Chlorocebus aethiops; D006801:Humans; D020128:Inhibitory Concentration 50; D008055:Lipids / Q000737:chemistry / Q000493:pharmacokinetics; D008954:Models, Biological; D009943:Organophosphorus Compounds / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects*; D014349:Trypanosoma cruzi / Q000187:drug effects*; D014451:Ubiquinone / Q000031:analogs & derivatives / Q000737:chemistry / Q000493:pharmacokinetics / Q000494:pharmacology; D014709:Vero Cells
chemical_list: D000977:Antiparasitic Agents; D002412:Cations; D008055:Lipids; D009943:Organophosphorus Compounds; D014451:Ubiquinone; C429014:mitoquinone