title: In vivo biostability of polyurethane-organosilicate nanocomposites.
abstract: Organically modified layered silicates were incorporated into a polyether soft-segment polyurethane to form composites of at least delaminated morphology. The primary organic modifier was a quaternary ammonium compound; however, one composite included an alternative amino undecanoic acid-modified silicate. The composites' biostability was assessed in an in vivo ovine model over a period of 6 weeks. Attenuated total reflectance-Fourier transform infrared analysis and semi-quantitative scanning electron microscopy image rating indicate a significant enhancement of the base polyurethane biostability with the inclusion of silicate at 3 wt.%. The potential effect at 15 wt.% was confounded by probable leaching of the quaternary ammonium compound affecting the tissue response. The amino undecanoic acid composite compared favourably with the quaternary ammonium compound composite of equivalent silicate loading, and offers the promise of a more favourable tissue response.
authors.affiliation: Graduate School of Biomedical Engineering, University of New South Wales, NSW 2052, Australia. katie.styan@gmail.com
authors.forename: Katie E
authors.initials: KE
authors.lastname: Styan
authors.forename: Darren J
authors.initials: DJ
authors.lastname: Martin
authors.forename: Anne
authors.initials: A
authors.lastname: Simmons
authors.forename: Laura A
authors.initials: LA
authors.lastname: Poole-Warren
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D007249:Inflammation / Q000139:chemically induced; D008855:Microscopy, Electron, Scanning; D053761:Nanocomposites; D009930:Organic Chemicals / Q000737:chemistry*; D011140:Polyurethanes / Q000737:chemistry*; D012756:Sheep; D017640:Silicates / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D001672:Biocompatible Materials; D009930:Organic Chemicals; D011140:Polyurethanes; D017640:Silicates