title: Therapeutic effects of aqueous extracts of Petroselinum sativum on ethylene glycol-induced kidney calculi in rats.
abstract: OBJECTIVE
  To investigate the therapeutic effects of the aqueous extract of Petroselinum Sativum aerial parts and roots on kidney calculi.
  
  
  METHODS
  Thirty-six male Wistar rats were randomly assigned into 6 groups and treated for 30 days. Group A served as normal control and group B received 1% ethylene glycol in drinking water. Groups C, D, E, and F received 1% ethylene glycol from day 0 and were used as the treatment subjects. Rats in groups C and D received 200 and 600 mg/kg body weight of aerial parts aqueous extract, respectively, and those in groups E and F received 200 and 600 mg/kg body weight of root aqueous extract in drinking water, respectively, from the 14th day of the experiment.
  
  
  RESULTS
  On the 14th and 30th days of the experiment, serum level of magnesium (1.71 ± 0.12 and 3.81 ± 0.25, respectively) decreased significantly while serum level of calcium (10.45 ± 0.26 and 11.33 ± 0.18, respectively) increased significantly in group B compared with the control group (14th day: magnesium = 2.87 ± 0.17 and calcium = 8.80 ± 0.00 and 30th day: magnesium = 6.01 ± 0.00 and calcium = 8.30 ± 0.22; P < .001). In the treatment groups of C, D, E, and F, the number of deposits decreased significantly compared with group B on the 30th day (P < .001). The weight of the kidneys increased significantly in group B (2.01 ± 0.17) compared with the control group (1.52 ± 0.07) and decreased significantly in treatment groups (P < .05).
  
  
  CONCLUSIONS
  Petroselinum Sativum has a therapeutic effect on calcium oxalate stones in rats with nephrolithiasis and reduces the number of calcium oxalate deposits.
authors.affiliation: Department of Physiology, Neyshabur Branch, Islamic Azad University, Neyshabur, Iran. s_milad2003@yahoo.com
authors.forename: Jafar
authors.initials: J
authors.lastname: Saeidi
authors.forename: Hadi
authors.initials: H
authors.lastname: Bozorgi
authors.forename: Ahmad
authors.initials: A
authors.lastname: Zendehdel
authors.forename: Jamshid
authors.initials: J
authors.lastname: Mehrzad
mesh_terms: D000818:Animals; D002118:Calcium / Q000097:blood; D002129:Calcium Oxalate / Q000378:metabolism*; D019855:Ethylene Glycol; D007668:Kidney / Q000378:metabolism / Q000473:pathology*; D007669:Kidney Calculi / Q000139:chemically induced / Q000188:drug therapy*; D008274:Magnesium / Q000097:blood; D008297:Male; D009929:Organ Size; D028528:Petroselinum; D008517:Phytotherapy; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000627:therapeutic use*; D018517:Plant Roots; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
chemical_list: D010936:Plant Extracts; D002129:Calcium Oxalate; D019855:Ethylene Glycol; D008274:Magnesium; D002118:Calcium