title: The involvement of TGF-β1 and CTGF in regional gingival overgrowth.
abstract: Gingival overgrowth is a multifactorial and invalidating condition. Our research is about gingival overgrowth caused by gingival plaque, its purpose being the evaluation of the presence of gingivitis and/or parodontitis in patients with gingival growth and the extent in which there is a connection between gingival overgrowth and the inflammatory process that can contribute to an exceedingly stimulation of the overgrowth. Immunohistological study was conducted on human material--gingival mucosa that came from patients with ages between 20-65 years, divided into three groups: group I--control group, group II--patients with gingivitis, group III--patients with local or general periodontitis. The intensity of immunohistochemical staining of TGF-β1 and CTGF varies from one group to another, and also depends on the area of gingival mucosa that was observed. TGF-β1 has a crucial role in periodontal disease fibrogenesis by intensifying the action of CTGF.
authors.affiliation: Department of Histology, University of Medicine and Pharmacy of Craiova, Romania.
authors.forename: Elena Annabel
authors.initials: EA
authors.lastname: Niţulescu
authors.forename: Monica Mihaela
authors.initials: MM
authors.lastname: Crăiţoiu
authors.forename: Monica Ileana
authors.initials: MI
authors.lastname: Baniţă
authors.forename: Emma
authors.initials: E
authors.lastname: Drăghici
authors.forename: Ştefania
authors.initials: Ş
authors.lastname: Crăiţoiu
mesh_terms: D000328:Adult; D003094:Collagen / Q000737:chemistry; D055513:Connective Tissue Growth Factor / Q000378:metabolism*; D004848:Epithelium / Q000378:metabolism; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D005881:Gingiva / Q000378:metabolism*; D019214:Gingival Overgrowth / Q000378:metabolism* / Q000473:pathology; D005891:Gingivitis / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D007249:Inflammation; D008875:Middle Aged; D010510:Periodontal Diseases / Q000473:pathology; D010641:Phenotype; D053773:Transforming Growth Factor beta1 / Q000378:metabolism*
chemical_list: D053773:Transforming Growth Factor beta1; D055513:Connective Tissue Growth Factor; D003094:Collagen