title: Accuracy of computed tomography in determining lesion size in canine appendicular osteosarcoma.
abstract: Multidetector contrast enhanced computed tomography with acquisition of 0.625-mm thick transverse images was used to measure the extent of appendicular osteosarcoma in 10 dogs. The measured length of tumor based on CT was compared to the true length of tumor using histopathology. There was a statistically significant association with good correlation between the true length of osteosarcoma compared to the length of intramedullary/endosteal abnormalities on CT with a mean overestimation of 1.8% (SD = 15%). There was not a statistically significant association between the true tumor length and the length of periosteal proliferation on CT with a mean overestimation of 9.7% (SD = 30.3%). There was a statistically significant association, but with poor correlation, between the true tumor length compared to the length of abnormal contrast enhancement with a mean overestimation of 9.6% (SD = 34.8%). The extent of intramedullary/endosteal CT abnormalities assessed from submillimeter transverse images may be of value in assessing patient candidacy and surgical margins for limb-sparing surgery.
authors.affiliation: Department of Veterinary Clinical Sciences, The Ohio State University, Columbus, OH 43210, USA. kets4@hotmail.com
authors.forename: Ketaki S
authors.initials: KS
authors.lastname: Karnik
authors.forename: Valerie F
authors.initials: VF
authors.lastname: Samii
authors.forename: Steven E
authors.initials: SE
authors.lastname: Weisbrode
authors.forename: Cheryl A
authors.initials: CA
authors.lastname: London
authors.forename: Eric M
authors.initials: EM
authors.lastname: Green
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000662:veterinary*; D003287:Contrast Media; D004283:Dog Diseases / Q000000981:diagnostic imaging*; D004285:Dogs; D005552:Forelimb / Q000000981:diagnostic imaging*; D006614:Hindlimb / Q000000981:diagnostic imaging*; D061330:Multidetector Computed Tomography / Q000662:veterinary; D012516:Osteosarcoma / Q000000981:diagnostic imaging / Q000662:veterinary*; D014057:Tomography, X-Ray Computed / Q000662:veterinary*
chemical_list: D003287:Contrast Media