title: [Gout as a systemic disease. Manifestations, complications and comorbidities of hyperuricaemia].
abstract: Of all inflammatory rheumatic diseases gout has the highest prevalence. Patients with intermittent acute gout attacks are usually treated by primary care physicians. However, in cases of insufficient long-term control of serum uric acid levels, complications or atypical clinical manifestations may necessitate consultation with a rheumatologist in the further course of the disease. An oligoarticular or polyarticular presentation can give rise to the initial suspicion of rheumatoid or psoriatic arthritis. In these cases a careful clinical work-up supported by laboratory and imaging investigations is necessary and synovial fluid analysis is usually required. As in other rheumatic diseases extra-articular manifestations are of utmost importance for morbidity and mortality. Gout is a complex metabolic and inflammatory disease and besides articular symptoms the renal and cardiovascular effects of hyperuricemia are particularly relevant for the overall prognosis.
authors.affiliation: Medizinische Klinik und Poliklinik III, Abteilung Rheumatologie, Universitätsklinikum Carl Gustav Carus, Fetscherstr. 74, 01307, Dresden, Deutschland. anne-kathrin.tausche@uniklinikum-dresden.de
authors.forename: A-K
authors.initials: AK
authors.lastname: Tausche
authors.forename: B
authors.initials: B
authors.lastname: Manger
authors.forename: U
authors.initials: U
authors.lastname: Müller-Ladner
authors.forename: B
authors.initials: B
authors.lastname: Schmidt
mesh_terms: D006073:Gout / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D006801:Humans; D033461:Hyperuricemia / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*