title: Detection of asymptomatic cardiac metastasis and successful salvage chemotherapy comprising a prednisone, Etoposide, procarbazine, and cyclophosphamide regimen in an elderly Japanese patient suffering from a delayed recurrence of diffuse large B-cell lymphoma.
abstract: We report a case of facial diffuse large B-cell lymphoma (DLBCL) associated with recurrent metastasis in the heart and other sites in a 76-year-old Japanese woman. Initially, she developed DLBCL in her left upper eyelid that spread into the left orbit (Ann Arbor classification stage I). The lesion went into clinical regression after 4 cycles of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy followed by radiotherapy. More than 3 years later, the lymphoma recurred in her facial skin, together with metastases in the mediastinal lymph nodes and the heart; the tumor in the heart was successfully detected by PET/CT and cardiac MRI. To treat the recurrent lesions, we performed a salvage chemotherapy regimen comprising prednisone, etoposide, procarbazine, and cyclophosphamide, which successfully induced tumor regression.
authors.affiliation: Department of Medical Oncology, Tohoku University Hospital, Sendai, Japan.
authors.forename: Keita
authors.initials: K
authors.lastname: Tagami
authors.forename: Shigeru
authors.initials: S
authors.lastname: Tanda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kato
authors.forename: Atsushi
authors.initials: A
authors.lastname: Tashiro
authors.forename: Kenya
authors.initials: K
authors.lastname: Saji
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Komaru
authors.forename: Muneo
authors.initials: M
authors.lastname: Tanida
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nakura
authors.forename: Kenichi
authors.initials: K
authors.lastname: Ishizawa