title: [Cardiotoxicity of conservative treatment of solid tumors].
abstract: With an increasing number of long-term breast cancer survivors, the number of patients experiencing anthracycline-induced cardiotoxicity increas too. Anthracycline--and nonanthracycline-induced cardiac toxicity--clinically significant and frequent adverse event of conservative treatment of cancer. Echocardiogram and multigated acquisition (MUGA) scan--modalities that may overlook early changes that could identify patients at risk for anthracycline-related cardiotoxicity. However, monitoring cardiac function before and during therapy, continuous infusions of drugs, limiting lifetime anthracycline dose, using cardioprotectants such as dexrazoxane, and developing lipid formulations, may decreased risk of cardiotoxicity.
authors.forename: L A
authors.initials: LA
authors.lastname: Sivak
authors.forename: A V
authors.initials: AV
authors.lastname: Askol'skiĭ
authors.forename: S A
authors.initials: SA
authors.lastname: Lial'kin
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Klimanov
authors.forename: N N
authors.initials: NN
authors.lastname: Maĭdanevich
authors.forename: N V
authors.initials: NV
authors.lastname: Kasap
mesh_terms: D018943:Anthracyclines / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001940:Breast / Q000187:drug effects / Q000473:pathology; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D002317:Cardiovascular Agents / Q000008:administration & dosage / Q000627:therapeutic use; D019561:Echocardiography, Four-Dimensional; D005260:Female; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D006331:Heart Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D011929:Razoxane / Q000008:administration & dosage / Q000627:therapeutic use*; D012307:Risk Factors; D017741:Survivors; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use; D014463:Ultrasonography; D014815:Vitamins / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; D002317:Cardiovascular Agents; D014815:Vitamins; D014451:Ubiquinone; D011929:Razoxane; C024989:coenzyme Q10