title: Physical activity attenuates the negative effect of low birth weight on leptin levels in European adolescents; the HELENA study.
abstract: We examined whether physical activity (PA) influences the association between birth weight and serum leptin in adolescents. The study comprised a total of 538 adolescents (315 girls), aged 12.5-17.49 years, born at term (≥ 37 weeks of gestation). We measured serum leptin levels and time engaged in moderate-vigorous PA (MVPA) by accelerometry. There was an interaction effect between birth weight and meeting the PA recommendations (60 min/day MVPA) on leptin levels in girls (P = 0.023) but not in boys (P = 0.809). Birth weight was negatively associated with leptin levels in girls not meeting the PA recommendations (i.e. more than 60 min/day of MVPA) (β = -0.096, P = 0.009), whereas no significant association was observed in those meeting the PA recommendations (β = -0.061, P = 0.433). In conclusion, meeting the PA recommendations may attenuate the negative effect of low birth weight on serum leptin levels in European female adolescents.
authors.affiliation: Department of Nutrition and Food Science, University of the Basque Country, Vitoria, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Labayen
authors.forename: F B
authors.initials: FB
authors.lastname: Ortega
authors.forename: L A
authors.initials: LA
authors.lastname: Moreno
authors.forename: M
authors.initials: M
authors.lastname: Gonzalez-Gross
authors.forename: D
authors.initials: D
authors.lastname: Jimenez-Pavon
authors.forename: D
authors.initials: D
authors.lastname: Martínez-Gómez
authors.forename: C
authors.initials: C
authors.lastname: Breidenassel
authors.forename: A
authors.initials: A
authors.lastname: Marcos
authors.forename: D
authors.initials: D
authors.lastname: Molnar
authors.forename: Y
authors.initials: Y
authors.lastname: Manios
authors.forename: M
authors.initials: M
authors.lastname: Plada
authors.forename: A
authors.initials: A
authors.lastname: Kafatos
authors.forename: S
authors.initials: S
authors.lastname: De Henauw
authors.forename: B
authors.initials: B
authors.lastname: Mauro
authors.forename: M
authors.initials: M
authors.lastname: Zaccaria
authors.forename: K
authors.initials: K
authors.lastname: Widhalm
authors.forename: F
authors.initials: F
authors.lastname: Gottrand
authors.forename: M J
authors.initials: MJ
authors.lastname: Castillo
authors.forename: M
authors.initials: M
authors.lastname: Sjöström
authors.forename: J R
authors.initials: JR
authors.lastname: Ruiz
mesh_terms: D056044:Actigraphy; D000293:Adolescent; D005060:Europe; D005260:Female; D005865:Gestational Age; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D020738:Leptin / Q000097:blood*; D016014:Linear Models; D008297:Male; D009043:Motor Activity; D012737:Sex Factors; D013997:Time Factors
chemical_list: D020738:Leptin