title: Subtropical grass pollen allergens are important for allergic respiratory diseases in subtropical regions.
abstract: BACKGROUND
  Grass pollen allergens are a major cause of allergic respiratory disease but traditionally prescribing practice for grass pollen allergen-specific immunotherapy has favoured pollen extracts of temperate grasses. Here we aim to compare allergy to subtropical and temperate grass pollens in patients with allergic rhinitis from a subtropical region of Australia.
  
  
  METHODS
  Sensitization to pollen extracts of the subtropical Bahia grass (Paspalum notatum), Johnson grass (Sorghum halepense) and Bermuda grass (Cynodon dactylon) as well as the temperate Ryegrass (Lolium perenne) were measured by skin prick in 233 subjects from Brisbane. Grass pollen-specific IgE reactivity was tested by ELISA and cross-inhibition ELISA.
  
  
  RESULTS
  Patients with grass pollen allergy from a subtropical region showed higher skin prick diameters with subtropical Bahia grass and Bermuda grass pollens than with Johnson grass and Ryegrass pollens. IgE reactivity was higher with pollen of Bahia grass than Bermuda grass, Johnson grass and Ryegrass. Patients showed asymmetric cross-inhibition of IgE reactivity with subtropical grass pollens that was not blocked by temperate grass pollen allergens indicating the presence of species-specific IgE binding sites of subtropical grass pollen allergens that are not represented in temperate grass pollens.
  
  
  CONCLUSIONS
  Subtropical grass pollens are more important allergen sources than temperate grass pollens for patients from a subtropical region. Targeting allergen-specific immunotherapy to subtropical grass pollen allergens in patients with allergic rhinitis in subtropical regions could improve treatment efficacy thereby reducing the burden of allergic rhinitis and asthma.
authors.affiliation: Lung and Allergy Research Centre, School of Medicine, The University of Queensland, Princess Alexandra Hospital Clinical Division, Woolloongabba, QLD 4076, Australia. j.davies2@uq.edu.au.
authors.forename: Janet Mary
authors.initials: JM
authors.lastname: Davies
authors.forename: Hongzhuo
authors.initials: H
authors.lastname: Li
authors.forename: Melissa
authors.initials: M
authors.lastname: Green
authors.forename: Michelle
authors.initials: M
authors.lastname: Towers
authors.forename: John Warrick
authors.initials: JW
authors.lastname: Upham