title: Preparation and characterization of well ordered mesoporous diopside nanobiomaterial.
abstract: Well ordered mesoporous diopside (OMD) nanobiomaterial was synthesized by a sol-gel process. The in vitro bioactivity of the OMD was evaluated by investigating the apatite-forming ability in simulated body fluid (SBF), and the hemostatic activity of the OMD was determined by measuring the activated partial thromboplastin time (APTT) and prothrombin time (PT) in vitro. The results suggested that the OMD exhibited excellent in vitro bioactivity, with surface apatite formation for OMD exceeding that of non-mesoporous diopside (n-MD) at 7 days. Moreover, the OMD with high surface area possessed good hemostatic property because it could absorb a large number of water from the blood. In conclusion, the prepared OMD had excellent bioactivity and hemostatic activity, which can not only be applied as bone repair biomaterial for bone regeneration, but also as hemostatic agent for surgery hemostasis.
authors.affiliation: Key Laboratory for Ultrafine Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, PR China.
authors.forename: Jie
authors.initials: J
authors.lastname: Wei
authors.forename: Jingxiong
authors.initials: J
authors.lastname: Lu
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Yan
authors.forename: Hong
authors.initials: H
authors.lastname: Li
authors.forename: Jian
authors.initials: J
authors.lastname: Ma
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Wu
authors.forename: Chenglong
authors.initials: C
authors.lastname: Dai
authors.forename: Changsheng
authors.initials: C
authors.lastname: Liu
mesh_terms: D001672:Biocompatible Materials; D006487:Hemostasis / Q000187:drug effects; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D049329:Nanostructures; D012824:Silicic Acid / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D012824:Silicic Acid; C074224:diopside