title: Enzymatic reductions for the regio- and stereoselective synthesis of hydroxy-keto esters and dihydroxy esters.
abstract: Ketoreductases were utilized for the stereoselective synthesis of δ-hydroxy-β-keto esters, β-hydroxy-δ-keto esters, and β,δ-dihydroxy esters. Seven out of eight possible stereoisomers were obtained from the enzymatic reduction of the corresponding β,δ-diketo ester in high enantio- and diastereomeric excess.
authors.affiliation: Department of Chemistry, University of Crete, Heraklion 71003, Crete, Greece.
authors.forename: Anna
authors.initials: A
authors.lastname: Bariotaki
authors.forename: Dimitris
authors.initials: D
authors.lastname: Kalaitzakis
authors.forename: Ioulia
authors.initials: I
authors.lastname: Smonou
mesh_terms: D002384:Catalysis; D004952:Esters; D015394:Molecular Structure; D019255:NADPH Oxidases / Q000378:metabolism*; D010084:Oxidation-Reduction; D013237:Stereoisomerism
chemical_list: D004952:Esters; D019255:NADPH Oxidases