title: Bioactive glass enhances bone ingrowth into the porous titanium coating on orthopaedic implants.
abstract: OBJECTIVE
  The aim of the study was to verify the ability of nanoparticulate bioactive glass (BAG) to infiltrate into the porous titanium (Ti) layer on Ti-based implants to promote osseointegration.
  
  
  METHODS
  The porous titanium layer on Ti-based implants was impregnated with nanoparticulate BAG. The implants without or with BAG were implanted bilaterally in tibial holes of ten New Zealand white rabbits. The rabbits were sacrificed after ten weeks for examinations. Beside histological examination, EDXS analysis of polished cross-sections of explanted implants was also performed with the aim to quantitatively evaluate the bone-to-pore contact and bone-in-pore ratio.
  
  
  RESULTS
  After ten weeks, EDXS analyses of cross-sections of the explanted implants confirmed that bioactive glass was fully resorbed and that the pores throughout the thickness of the porous titanium layer were to a large extent filled with a new bone. In the absence of bioactive glass, only the outer part of the porous layer was filled with bone. The implants without BAG in the porous Ti-layer exhibited similar bone-to-pore contact, while significant improvement of bone ingrowth into the pores was observed for the implants with BAG (38%), as opposed to those without it (22%).
  
  
  CONCLUSIONS
  This study confirmed that the nanoparticulate bioactive glass within the porous titanium surface layer on implants promotes osseointegration and stimulates the formation of bone within the pores.
authors.affiliation: Department for Nanostructured Materials, Jožef Stefan Institute, Ljubljana, Slovenia.
authors.forename: Nataša
authors.initials: N
authors.lastname: Drnovšek
authors.forename: Saša
authors.initials: S
authors.lastname: Novak
authors.forename: Urška
authors.initials: U
authors.lastname: Dragin
authors.forename: Miran
authors.initials: M
authors.lastname: Čeh
authors.forename: Matevž
authors.initials: M
authors.lastname: Gorenšek
authors.forename: Marko
authors.initials: M
authors.lastname: Gradišar
mesh_terms: D000818:Animals; D001846:Bone Development / Q000502:physiology*; D020099:Coated Materials, Biocompatible; D005898:Glass; D008297:Male; D008855:Microscopy, Electron, Scanning; D023421:Models, Animal; D053758:Nanoparticles; D016062:Porosity; D019736:Prostheses and Implants; D011817:Rabbits; D013977:Tibia / Q000502:physiology / Q000601:surgery / Q000648:ultrastructure; D014025:Titanium
chemical_list: D020099:Coated Materials, Biocompatible; D014025:Titanium