title: Preperation of (99m)Tc labeled 5-fluorouracil as a potential diagnostic agent in advanced breast cancer: first clinical trial.
abstract: The chemotherapeutic drug 5-fluorouracil (5FU) is used for treatment of various types of cancers. The present study was conducted to evaluate the potential of this drug as a diagnostic radiopharmaceutical in advanced breast cancer. We have labeled 5FU by using the stannous chloride reduction method with 555MBq of technetium-99m ((99m)Tc). The (99m)Tc-5FU was injected intravenously in 4 patients having advanced breast cancer. Dynamic and static images were taken at various time intervals till 2h. Whole body images were used to calculate the percentage of the injected dose, in each organ. Target to non target ratio was calculated to find out the optimum time for imaging. In conclusion, our study showed that (99m)Tc-5FU was a promising agent for diagnosing advanced breast cancer with optimum visualization at 1h.
authors.affiliation: Radiopharmacy Division, Institute of Nuclear Medicine and Oncology, New Campus Road, P. O. Box 10068, Lahore- 54600, Pakistan.
authors.forename: Ume Kalsoom
authors.initials: UK
authors.lastname: Dar
authors.forename: Irfan Ullah
authors.initials: IU
authors.lastname: Khan
authors.forename: Muhammad
authors.initials: M
authors.lastname: Javed
authors.forename: Rashid
authors.initials: R
authors.lastname: Rasheed
authors.forename: Zaid
authors.initials: Z
authors.lastname: Mahmoud
authors.forename: Syed Waqar
authors.initials: SW
authors.lastname: Hyder
authors.forename: Sohail Murad
authors.initials: SM
authors.lastname: Bhatti
authors.forename: Jamil
authors.initials: J
authors.lastname: Anwar
mesh_terms: D000328:Adult; D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics / Q000633:toxicity; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism*; D005240:Feasibility Studies; D005260:Female; D005472:Fluorouracil / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000493:pharmacokinetics; D006801:Humans; D007553:Isotope Labeling; D008657:Metabolic Clearance Rate; D009928:Organ Specificity; D015609:Organotechnetium Compounds / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D011817:Rabbits; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000493:pharmacokinetics; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014018:Tissue Distribution
chemical_list: D000970:Antineoplastic Agents; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C532874:technetium 99m 5-fluorouracil; D005472:Fluorouracil