title: Clostridium difficile infection: the scope of the problem.
abstract: Clostridium difficile infection (CDI) is increasingly common, and it is associated with significant morbidity, mortality, and cost burden for patients and the healthcare system. The severity and rates of recurrent CDI and associated mortality are also increasing. This article is an overview of the changes in CDI epidemiology that have occurred since the turn of the century and the current scope of the problem. The 3 articles that follow in this supplement address the diagnosis and treatment of initial and recurrent CDI, and current practice guidelines for the prevention and control of CDI in the hospital setting.
authors.affiliation: Division of Infectious Disease, Washington University School of Medicine, St Louis, Missouri 63110, USA. edubberk@DOM.wustl.edu
authors.forename: Erik
authors.initials: E
authors.lastname: Dubberke
mesh_terms: D016360:Clostridioides difficile / Q000472:pathogenicity*; D003015:Clostridium Infections / Q000453:epidemiology* / Q000276:immunology / Q000635:transmission; D017714:Community-Acquired Infections / Q000453:epidemiology* / Q000382:microbiology / Q000635:transmission; D003428:Cross Infection / Q000453:epidemiology* / Q000382:microbiology / Q000635:transmission; D006801:Humans; D015994:Incidence; D015995:Prevalence; D012008:Recurrence; D014481:United States / Q000453:epidemiology