title: [Resveratrol: a neuroprotective polyphenol in the Mediterranean diet].
abstract: BACKGROUND
  Resveratrol is a polyphenol present in grapes, some nuts and dried fruits, and red wine. A number of beneficial properties have been attributed to this compound. Its potential neuroprotective effects are the subject of much research today.
  
  
  OBJECTIVE
  To review the effects of resveratrol, and more particularly those related to its capacity to offer protection against the neurodegeneration associated with several pathologies and traumatic injuries in the central nervous system.
  
  
  METHODS
  It has been suggested that the daily consumption of red wine, and therefore of resveratrol, could account for the so-called 'French paradox', according to which the population in the south of France, despite eating a diet that is relatively high in saturated fats, presents a low risk of heart disease. From this first evidence of the cardioprotective properties of resveratrol, its study has been extended and equally attractive biopharmacological effects have now been found in many different fields. Thus, neuroprotective effects have been found in models of neurodegeneration (Alzheimer's, Parkinson's or Huntington's disease, or diverse neuropathies), of ischaemia and of brain and spinal cord injury, but further clinical data are still needed in this regard.
  
  
  CONCLUSIONS
  Although few studies have been conducted in humans, recent findings in experimental models of neurological pathology are encouraging and open up the doors to future clinical studies that will allow the therapeutic value of resveratrol to be determined.
authors.affiliation: Departamento de Farmacología y Nutrición y Unidad Asociada al Instituto de Química Médica del CSIC, Universidad Rey Juan Carlos, Facultad de Ciencias de la Salud, 28922 Alcorcon, Espana.
authors.forename: Visitación
authors.initials: V
authors.lastname: López-Miranda
authors.forename: M Luisa
authors.initials: ML
authors.lastname: Soto-Montenegro
authors.forename: Gema
authors.initials: G
authors.lastname: Vera
authors.forename: Esperanza
authors.initials: E
authors.lastname: Herradón
authors.forename: Manuel
authors.initials: M
authors.lastname: Desco
authors.forename: Raquel
authors.initials: R
authors.lastname: Abalo
mesh_terms: D016229:Amyloid beta-Peptides / Q000378:metabolism; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use; D001682:Biological Availability; D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D002470:Cell Survival; D002561:Cerebrovascular Disorders / Q000517:prevention & control*; D004260:DNA Repair; D038441:Diet, Mediterranean; D006801:Humans; D009419:Nerve Tissue Proteins / Q000502:physiology; D019636:Neurodegenerative Diseases / Q000517:prevention & control*; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D010523:Peripheral Nervous System Diseases / Q000517:prevention & control; D015427:Reperfusion Injury / Q000517:prevention & control; D000077185:Resveratrol; D056564:Sirtuin 1 / Q000502:physiology; D013116:Spinal Cord / Q000098:blood supply; D013267:Stilbenes / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use*; D020196:Trauma, Nervous System / Q000188:drug therapy; D027843:Vitis / Q000737:chemistry; D014920:Wine / Q000032:analysis
chemical_list: D016229:Amyloid beta-Peptides; D000975:Antioxidants; D002316:Cardiotonic Agents; D009419:Nerve Tissue Proteins; D018696:Neuroprotective Agents; D013267:Stilbenes; C447939:SIRT1 protein, human; D056564:Sirtuin 1; D000077185:Resveratrol