title: Clinical profiles and long-term outcomes of patients with pancreatic ductal adenocarcinoma and diabetes mellitus.
abstract: BACKGROUND
  Diabetes mellitus (DM) is considered to be a possible risk factor and/or a manifestation of pancreatic ductal adenocarcinoma (PDAC). This study is aimed at analysing the potential association of diabetes mellitus with the development and pathogenic degrees of PDAC and post-surgical survival of Chinese Han PDAC patients.
  
  
  METHODS
  A total of 1123 patients with PDAC were recruited and included 256 patients with diabetes mellitus within 2 years (new-onset) and 62 patients with diabetes mellitus ≥ 2 years (long-standing). Additional 466 patients with type 2 diabetes mellitus were included in this study. Their clinical characteristics and long-term outcomes were analysed.
  
  
  RESULTS
  In comparison with patients with type 2 diabetes mellitus alone, PDAC patients with new-onset diabetes mellitus had an older onset age of diabetes mellitus and lower body mass index (BMI). Among PDAC cases, patients with new-onset diabetes mellitus were associated with neural invasion, poor tumour differentiation and shorter post-surgical survival. However, more than half of these patients became euglycemic after surgical resection of tumours.
  
  
  CONCLUSIONS
  PDAC patients developed new-onset diabetes mellitus at an older age, and they had shorter post-surgical survival. The underlying mechanisms by which comorbid diabetes mellitus affect the clinical profiles and outcomes of PDAC patients deserve further researches.
authors.affiliation: Department of Gastroenterology, Changhai Hospital of Second Military Medical University, Shanghai, China.
authors.forename: Qiwen
authors.initials: Q
authors.lastname: Ben
authors.forename: Maojin
authors.initials: M
authors.lastname: Xu
authors.forename: Ying
authors.initials: Y
authors.lastname: Jiang
authors.forename: Yaozong
authors.initials: Y
authors.lastname: Yuan
authors.forename: Kaixuan
authors.initials: K
authors.lastname: Wang
authors.forename: Jun
authors.initials: J
authors.lastname: Fang
authors.forename: Zhaoshen
authors.initials: Z
authors.lastname: Li
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D017668:Age of Onset; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D021441:Carcinoma, Pancreatic Ductal / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000473:pathology; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D001786:Blood Glucose