title: [Effects of sea cucumber cerebroside and its long-chain base on lipid and glucose metabolism in obese mice].
abstract: OBJECTIVE
  To investigate the effect of sea cucumber cerebroside(SCC) and its long-chain base(LCB) on lipid and glucose metabolism in obese mice.
  
  
  METHODS
  The mouse obese model was established by feeding high fat diet. The mice were randomly assigned to 4 groups: control group, model group, SCC group and LCB group. After 4 weeks, the glucose tolerance test was undertaken. After 5 weeks, the body fat content, organic indexes, serum lipid level, glycemic index and liver lipid level were determined.
  
  
  RESULTS
  Compared with the model group, the glucose tolerance in the SCC group and LCB group was ameliorated significantly (P<0.01, P<0.05); glycemic index (P<0.01, P<0.01), the weight of adipose tissue (P<0.05, P<0.01) and the hepatic TG were reduced significantly (P<0.05, P<0.05).
  
  
  CONCLUSIONS
  Sea cucumber cerebroside and its long-chain base can improve the glucose and lipid metabolism in obese mice.
authors.affiliation: College of Food Science and Technology, Ocean University of China, Qingdao 266003, China.
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Gao
authors.forename: Xin
authors.initials: X
authors.lastname: Zhou
authors.forename: Xiao-qian
authors.initials: XQ
authors.lastname: Hu
authors.forename: Chang-hu
authors.initials: CH
authors.lastname: Xue
authors.forename: Jie
authors.initials: J
authors.lastname: Xu
authors.forename: Yu-ming
authors.initials: YM
authors.lastname: Wang
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D002554:Cerebrosides / Q000494:pharmacology*; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D009765:Obesity / Q000097:blood* / Q000188:drug therapy; D012616:Sea Cucumbers / Q000737:chemistry*
chemical_list: D001786:Blood Glucose; D002554:Cerebrosides; D008055:Lipids