title: Prevalence and determinants of coronary artery disease in first-degree relatives of premature coronary artery disease.
abstract: BACKGROUND
  This study aimed to investigate the prevalence of subclinical coronary artery disease (CAD) in first-degree relatives (FDRs) with premature CAD and its associating factors other than conventional risk factors.
  
  
  METHODS
  A total of 122 FDRs (58 men, 50±7 years) of patients with premature CAD were enrolled. The individuals who had undergone health checkups were included in the control group. Multidetector coronary computed tomography was performed to detect subclinical CAD.
  
  
  RESULTS
  The prevalence of subclinical CAD (35 vs. 14%, P<0.001) and at least 50% subclinical CAD (16 vs. 2.5%, P<0.001) was higher in FDRs than that in the control group. In conditional regression analysis, the urinary albumin-creatinine ratio showed a significant interaction with CAD in FDRs than the control (odds ratio 1.063, 95% confidence interval 1.009-1.118, P=0.021).
  
  
  CONCLUSIONS
  FDRs of premature CAD are more prevalent in subclinical CAD independent of conventional risk factors. Urinary albumin-creatinine ratio may have an interaction with the development of subclinical CAD in FDRs of premature CAD.
authors.affiliation: Department of Internal Medicine, Kangnam Sacred Heart Hospital, Seoul, South Korea.
authors.forename: Min-Kyung
authors.initials: MK
authors.lastname: Kang
authors.forename: Hyuk-Jae
authors.initials: HJ
authors.lastname: Chang
authors.forename: Young Jin
authors.initials: YJ
authors.lastname: Kim
authors.forename: Ae Ran
authors.initials: AR
authors.lastname: Park
authors.forename: Sungha
authors.initials: S
authors.lastname: Park
authors.forename: Yangsoo
authors.initials: Y
authors.lastname: Jang
authors.forename: Namsik
authors.initials: N
authors.lastname: Chung
mesh_terms: D000328:Adult; D000418:Albumins / Q000378:metabolism*; D016022:Case-Control Studies; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000453:epidemiology* / Q000652:urine; D003404:Creatinine / Q000652:urine*; D005190:Family; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D056910:Republic of Korea; D012307:Risk Factors; D014057:Tomography, X-Ray Computed
chemical_list: D000418:Albumins; D003404:Creatinine