title: A new flavonoid glycoside and other constituents from Dracocephalum moldavica.
abstract: A systematic phytochemical investigation of the aerial parts of Dracocephalum moldavica led to the isolation of 1 new and 16 known compounds. Based on spectroscopic analyses, the new compound was elucidated as a flavonoid glycoside, acacetin-7-O-(4″-acetyl)-glucopyranoside (1). The 16 known compounds were identified as: 9 flavonoids (2-10), 2 lignans (11-12), 4 triterpeniods (13-16) and 1 menthane-type monoterpenoid (17). All the 17 compounds were reported for the first time from D. moldavica. Compound 1 exhibited mild radical scavenging activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH). Although compound 17, named as citrylidene malonic acid, was a known compound, it possessed an uncommon tricyclic dilactone skeleton, the structure was secured by X-ray crystallography. In addition, compound 17 was tested for cytotoxic activity against A549 cell line, only weak cytotoxicity was shown.
authors.affiliation: a Department of Natural Products Chemistry, School of Pharmaceutical Sciences, Shandong University, 44 Wenhuaxi Road, Jinan 250012, PR China.
authors.forename: Shuang
authors.initials: S
authors.lastname: Yang
authors.forename: Limei
authors.initials: L
authors.lastname: Wang
authors.forename: Xiaojiang
authors.initials: X
authors.lastname: Guo
authors.forename: Hongxiang
authors.initials: H
authors.lastname: Lou
authors.forename: Dongmei
authors.initials: D
authors.lastname: Ren
mesh_terms: D001713:Biphenyl Compounds / Q000737:chemistry; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D005419:Flavonoids / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000737:chemistry; D006027:Glycosides / Q000737:chemistry*; D006801:Humans; D019686:Lamiaceae / Q000737:chemistry*; D010851:Picrates / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry
chemical_list: D001713:Biphenyl Compounds; D005419:Flavonoids; D016166:Free Radical Scavengers; D006027:Glycosides; D010851:Picrates; D014315:Triterpenes; C004931:1,1-diphenyl-2-picrylhydrazyl