title: Curcumin loaded-PLGA nanoparticles conjugated with Tet-1 peptide for potential use in Alzheimer's disease.
abstract: Alzheimer's disease is a growing concern in the modern world. As the currently available medications are not very promising, there is an increased need for the fabrication of newer drugs. Curcumin is a plant derived compound which has potential activities beneficial for the treatment of Alzheimer's disease. Anti-amyloid activity and anti-oxidant activity of curcumin is highly beneficial for the treatment of Alzheimer's disease. The insolubility of curcumin in water restricts its use to a great extend, which can be overcome by the synthesis of curcumin nanoparticles. In our work, we have successfully synthesized water-soluble PLGA coated- curcumin nanoparticles and characterized it using different techniques. As drug targeting to diseases of cerebral origin are difficult due to the stringency of blood-brain barrier, we have coupled the nanoparticle with Tet-1 peptide, which has the affinity to neurons and possess retrograde transportation properties. Our results suggest that curcumin encapsulated-PLGA nanoparticles are able to destroy amyloid aggregates, exhibit anti-oxidative property and are non-cytotoxic. The encapsulation of the curcumin in PLGA does not destroy its inherent properties and so, the PLGA-curcumin nanoparticles can be used as a drug with multiple functions in treating Alzheimer's disease proving it to be a potential therapeutic tool against this dreaded disease.
authors.affiliation: Bio Nano Electronics Research Center, Graduate School of Interdisciplinary New Science, Toyo University, Kawagoe, Saitama, Japan.
authors.forename: Anila
authors.initials: A
authors.lastname: Mathew
authors.forename: Takahiro
authors.initials: T
authors.lastname: Fukuda
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Nagaoka
authors.forename: Takashi
authors.initials: T
authors.lastname: Hasumura
authors.forename: Hisao
authors.initials: H
authors.lastname: Morimoto
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Yoshida
authors.forename: Toru
authors.initials: T
authors.lastname: Maekawa
authors.forename: Kizhikkilot
authors.initials: K
authors.lastname: Venugopal
authors.forename: D Sakthi
authors.initials: DS
authors.lastname: Kumar
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy*; D000682:Amyloid / Q000737:chemistry; D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D001692:Biological Transport; D045744:Cell Line, Tumor; D003474:Curcumin / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D019344:Lactic Acid / Q000737:chemistry*; D051379:Mice; D057054:Molecular Imaging; D058726:Nanoconjugates / Q000737:chemistry* / Q000633:toxicity; D053758:Nanoparticles / Q000737:chemistry*; D010446:Peptide Fragments / Q000737:chemistry*; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D055503:Protein Multimerization / Q000187:drug effects; D017433:Protein Structure, Secondary
chemical_list: D000682:Amyloid; D000975:Antioxidants; D058726:Nanoconjugates; D010446:Peptide Fragments; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D003474:Curcumin