title: Salivary gland carcinomas of the larynx: a national study in Denmark.
abstract: OBJECTIVE
  Salivary gland carcinomas of the larynx are rare. The purpose of this study is to present a national series of laryngeal salivary gland carcinoma patients and to bring a review of recent literature.
  
  
  METHODS
  By merging The Danish Cancer Registry, The National Pathology Registry and The National Patient Registry all registered patients with laryngeal salivary carcinomas diagnosed from 1990 to 2007 were identified. The histological slides were reviewed and data concerning age, sex, symptoms, topography, histology, treatment and outcome were registered. Based on a supplemented PubMed search a review of literature from 1991 to 2010 was performed.
  
  
  RESULTS
  Six Danish patients with a malignant salivary gland tumor in the larynx were identified resulting in an incidence of 0.001/100,000 inhabitants/year. Four had adenoid cystic carcinoma and two a mucoepidermoid carcinoma. All patients were male. The patients were treated with surgery and/or radiotherapy. Three patients had recurrent disease. One died of the primary disease and one died of other causes. Four are alive with no evidence of disease. Merging of actual study group with patients from recent literature resulted in 83 cases. The male vs. female ratio was 2:1, the most common location was the supraglottic region (52%) and the most predominant histological subtypes were adenoid cystic carcinoma (46%), mucoepidermoid carcinoma (35%) and adenocarcinoma NOS (12%).
  
  
  CONCLUSIONS
  Laryngeal salivary gland carcinoma is a rare disease with a male predominance and most often localized in the supraglottic region. Data concerning treatment and outcome are scarce, but primary surgery with utmost focus on free surgical margins is the treatment of choice. Recurrences are observed later than ten years after primary treatment and a long follow up time is advocated.
authors.affiliation: Department of ENT Head and Neck Surgery, Odense University Hospital, Odense, Denmark. doctortroels@gmail.com
authors.forename: Troels Krogh
authors.initials: TK
authors.lastname: Nielsen
authors.forename: Kristine
authors.initials: K
authors.lastname: Bjørndal
authors.forename: Annelise
authors.initials: A
authors.lastname: Krogdahl
authors.forename: Hanne
authors.initials: H
authors.lastname: Primdahl
authors.forename: Claus Andrup
authors.initials: CA
authors.lastname: Kristensen
authors.forename: Elo
authors.initials: E
authors.lastname: Andersen
authors.forename: Christian
authors.initials: C
authors.lastname: Godballe
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology* / Q000628:therapy; D000328:Adult; D000368:Aged; D003528:Carcinoma, Adenoid Cystic / Q000453:epidemiology / Q000628:therapy; D018277:Carcinoma, Mucoepidermoid / Q000453:epidemiology / Q000628:therapy; D003718:Denmark / Q000453:epidemiology; D005260:Female; D006801:Humans; D007822:Laryngeal Neoplasms / Q000453:epidemiology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D012468:Salivary Gland Neoplasms / Q000453:epidemiology* / Q000628:therapy; D012737:Sex Factors