title: Detection and phylogenetic assessment of conserved synteny derived from whole genome duplications.
abstract: Identification of intragenomic conservation of gene compositions in multiple chromosomal segments led to evidence of whole genome (WGDs) duplications. The process by which WGDs have been maintained and decayed provides us with clues for understanding how the genome evolves. In this chapter, we summarize current understanding of phylogenetic distribution and evolutionary impact of WGDs, introduce basic procedures to detect conserved synteny, and discuss typical pitfalls, as well as biological insights.
authors.affiliation: Genome Resource and Analysis Unit, RIKEN Center for Developmental Biology, Chuo-ku, Kobe, Japan. shigehiro.kuraku@uni-konstanz.de
authors.forename: Shigehiro
authors.initials: S
authors.lastname: Kuraku
authors.forename: Axel
authors.initials: A
authors.lastname: Meyer
mesh_terms: D000818:Animals; D019143:Evolution, Molecular; D020440:Gene Duplication / Q000235:genetics; D016678:Genome / Q000235:genetics*; D006801:Humans; D010802:Phylogeny; D026801:Synteny / Q000235:genetics*