title: Transcription control by long non-coding RNAs.
abstract: Non-coding RNAs have been found to regulate many cellular processes and thus expand the functional genetic repertoire contained within the genome. With the recent advent of genomic tools, it is now evident that these RNA molecules play central regulatory roles in many transcriptional programs. Here we discuss how they are targeted to promoters in several cases and how they operate at specific points in the transcription cycle to precisely control gene expression.
authors.affiliation: Department of Biochemistry and Biophysics, University of California, San Francisco, CA, USA.
authors.forename: Tyler
authors.initials: T
authors.lastname: Faust
authors.forename: Alan
authors.initials: A
authors.lastname: Frankel
authors.forename: Iván
authors.initials: I
authors.lastname: D'Orso
mesh_terms: D000818:Animals; D002843:Chromatin / Q000378:metabolism; D019938:Cyclin D1 / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D018398:Homeodomain Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D051379:Mice; D011401:Promoter Regions, Genetic; D012319:RNA Polymerase II / Q000235:genetics / Q000378:metabolism; D022661:RNA, Untranslated / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D002843:Chromatin; D018398:Homeodomain Proteins; D022661:RNA, Untranslated; D019938:Cyclin D1; D012319:RNA Polymerase II