title: [Epigenetics and colorectal cancer].
abstract: The epigenetic and physiological mechanisms that alter the structure of chromatin include the methylation of DNA, changes in the histones, and changes in RNA. A literature review has been carried out using PubMed on the evidence published on the association between epigenetics and colorectal cancer. The scientific literature shows that epigenetic changes, such as genetic modifications may be very significant in the origin of neoplastic disease, contributing both to the development and progression of the disease.
authors.affiliation: Servicio de Cirugía General y de Aparato Digestivo, Hospital Gutiérrez Ortega, Valdepeñas, Ciudad Real, España. pablomensan@hotmail.com
authors.forename: Pablo
authors.initials: P
authors.lastname: Menéndez
authors.forename: Pedro
authors.initials: P
authors.lastname: Villarejo
authors.forename: David
authors.initials: D
authors.lastname: Padilla
authors.forename: José María
authors.initials: JM
authors.lastname: Menéndez
authors.forename: José Antonio
authors.initials: JA
authors.lastname: Rodríguez Montes
mesh_terms: D015179:Colorectal Neoplasms / Q000235:genetics*; D019175:DNA Methylation; D057890:Epigenomics; D006801:Humans; D035683:MicroRNAs / Q000235:genetics
chemical_list: D035683:MicroRNAs