title: The first stereoselective total synthesis of (Z)-cryptomoscatone D2, a natural G₂ checkpoint inhibitor.
abstract: The first stereoselective synthesis of (Z)-cryptomoscatone D2, a naturally occurring G(2) checkpoint inhibitor, was accomplished using propane-1,3-diol as the starting material. The Maruoka asymmetric allylation, ring closing metathesis and the hydrogenation of the triple bond employing Lindlar's catalyst were involved as the key steps.
authors.affiliation: Organic Chemistry Division-I, Indian Institute of Chemical Technology (CSIR), Hyderabad 500 007, India.
authors.forename: Gandolla
authors.initials: G
authors.lastname: Chinna Reddy
authors.forename: Penagaluri
authors.initials: P
authors.lastname: Balasubramanyam
authors.forename: N
authors.initials: N
authors.lastname: Salvanna
authors.forename: Thummala
authors.initials: T
authors.lastname: Sreenivasulu Reddy
authors.forename: Biswanath
authors.initials: B
authors.lastname: Das
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000494:pharmacology; D002384:Catalysis; D045744:Cell Line, Tumor; D031369:Cryptocarya / Q000737:chemistry; D059565:G2 Phase Cell Cycle Checkpoints / Q000187:drug effects; D006801:Humans; D006865:Hydrogenation; D007783:Lactones / Q000138:chemical synthesis* / Q000494:pharmacology; D015394:Molecular Structure; D011409:Propylene Glycols / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: C573358:(Z)-cryptomoscatone D2; D000972:Antineoplastic Agents, Phytogenic; D007783:Lactones; D011409:Propylene Glycols