title: Mortality in ulcerative colitis and Crohn's disease. A population-based study in Finland.
abstract: BACKGROUND
  An increased mortality has been reported in patients with Crohn's disease (CD), while figures have remained similar or decreased in patients with ulcerative colitis (UC) compared to the population in general. We evaluated the long-term mortality risk of patients with inflammatory bowel diseases (IBD) in a well-defined population.
  
  
  METHODS
  The data were based on a prospective IBD register in our catchment area; follow-up covered 1986-2007. The population based cohort comprised 1915 adult patients, 1254 with UC, 550 with CD, and 111 with inflammatory bowel disease unclassified (IBDU). The mortality rate and causes of death were obtained from Statistics Finland.
  
  
  RESULTS
  We recorded 223 deaths among the 1915 patients with IBD within a follow-up of 29,644 person-years. The standardised mortality rate (SMR) was 1.14 in CD and 0.90 in UC. In cause-specific mortality; the risk of death in diseases of the digestive system was significantly increased in CD (SMR 5.38). The mortality in colorectal cancer was non-significantly increased in both UC and CD (SMR 1.80 and 1.88, respectively). Compared to the background population, there were significantly fewer deaths due to mental and behavioural disorders due to use of alcohol (0 observed, 10.2 expected in IBD).
  
  
  CONCLUSIONS
  The overall mortality in CD and CU was not different from that in the population. In cause-specific mortality, diseases of the digestive system were significantly increased. Deaths due to mental and behavioural disorders resulting from alcohol consumption were less common in patients with IBD than in the population at large in Finland.
authors.affiliation: Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland. pia.manninen@uta.fi
authors.forename: Pia
authors.initials: P
authors.lastname: Manninen
authors.forename: Anna-Liisa
authors.initials: AL
authors.lastname: Karvonen
authors.forename: Heini
authors.initials: H
authors.lastname: Huhtala
authors.forename: Martin
authors.initials: M
authors.lastname: Rasmussen
authors.forename: Maarit
authors.initials: M
authors.lastname: Salo
authors.forename: Leena
authors.initials: L
authors.lastname: Mustaniemi
authors.forename: Ismo
authors.initials: I
authors.lastname: Pirttiniemi
authors.forename: Pekka
authors.initials: P
authors.lastname: Collin
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D003093:Colitis, Ulcerative / Q000401:mortality*; D003424:Crohn Disease / Q000401:mortality*; D005260:Female; D005387:Finland / Q000453:epidemiology; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D011159:Population Surveillance / Q000379:methods*; D012189:Retrospective Studies; D017678:Sex Distribution; D015996:Survival Rate / Q000639:trends; D013997:Time Factors; D055815:Young Adult