title: Photo-degradation products of pramipexole.
abstract: Two pyrrolidine compounds (1 and 2) were isolated from photo-degradation of Bi-Sifrol tablets. Compound 1 was esterified to p-bromophenacyl ester as single-crystal, and then the structure was elucidated by single-crystal X-ray study. Compound 2 was determined by 2D NMR and mass spectra. Otherwise, we established that the photo-degradation of pramipexole was smoothly carried out in the methanol solution, and elucidate the degradation mechanism.
authors.affiliation: Sanyo Chemical Laboratory Co. Ltd, Tajii, Mihara-ku, Sakai, Osaka, Japan. nishimura@sanyokagaku.co.jp
authors.forename: Eiji
authors.initials: E
authors.lastname: Nishimura
authors.forename: Aya
authors.initials: A
authors.lastname: Kugimiya
authors.forename: Hideo
authors.initials: H
authors.lastname: Naoki
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Hamanaka
mesh_terms: D052160:Benzothiazoles / Q000737:chemistry* / Q000528:radiation effects; D008027:Light; D009682:Magnetic Resonance Spectroscopy; D010782:Photolysis; D000077487:Pramipexole; D011759:Pyrrolidines / Q000737:chemistry*; D013607:Tablets
chemical_list: C574962:(S,E)-2-(5-(carbamoylimino)-1-propylpyrrolidin-2yl) acid; C574961:(S,E)-2-(5-(cyanoimino)-1-propylpyrrolidin-2yl) acetic acid; D052160:Benzothiazoles; D011759:Pyrrolidines; D013607:Tablets; D000077487:Pramipexole