title: Passive smoke exposure of female rats caused aortic atherosclerotic precursor lesions in their offspring.
abstract: The aim of this study was to evaluate the presence and degree of preclinical atherosclerosis in pups of pregnant rats exposed to cigarette smoke. Abdominal aorta examined for atherosclerotic lesions and intimal medial thickness of the abdominal aorta was measured by image analysis. The study groups showed endothelial cellular losses, marked intimal injuries, elastic fiber damages, mononuclear cellular infiltration, and irregularities in internal elastic membrane, with pronounced damages as integrity losses and local fragmentations. The results provide evidence for development of an atherosclerotic process in the neonatal period, even in prenatal stage, long before the formation of smoke-related cardiovascular diseases.
authors.affiliation: Gulhane Military Medical Academy, Etlik, Turkey.
authors.forename: Turan
authors.initials: T
authors.lastname: Tunc
authors.forename: Umit
authors.initials: U
authors.lastname: Sarici
authors.forename: Secil
authors.initials: S
authors.lastname: Aydinoz
authors.forename: Onder
authors.initials: O
authors.lastname: Onguru
authors.forename: Abdulbaki
authors.initials: A
authors.lastname: Karaoglu
authors.forename: Bulent
authors.initials: B
authors.lastname: Uysal
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kul
authors.forename: Yusuf Sinan
authors.initials: YS
authors.lastname: Sirin
authors.forename: Emin
authors.initials: E
authors.lastname: Oztas
authors.forename: Halil
authors.initials: H
authors.lastname: Yaman
mesh_terms: D000818:Animals; D001012:Aorta, Abdominal / Q000473:pathology*; D003324:Coronary Artery Disease / Q000209:etiology* / Q000473:pathology*; D005260:Female; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*
chemical_list: D014028:Tobacco Smoke Pollution