title: Synthesis of selenoxo peptides and oligoselenoxo peptides employing LiAlHSeH.
abstract: Synthesis of selenoxo peptides by the treatment of N(α)-protected peptide esters with a combination of PCl(5) and LiAlHSeH is delineated. The method is simple, high-yielding, and free from racemization. Thus obtained selenoxo peptides are used as units for N-terminal chain extension through N(α)-deprotection/coupling to yield peptide-selenoxo peptide hybrids. Multiple selenation is demonstrated by conversion of two peptide bonds of tripeptides into selenoxo peptide bonds. Amino acid derived arylamides are also converted into aryl selenoamides. C(6)H(5)-CSeNH-Val-OMe 8f is obtained as single  crystal, and its structure was determined through X-ray diffraction study.
authors.affiliation: Peptide Research Laboratory, Department of Studies in Chemistry, Central College Campus, Bangalore University, Dr. B. R. Ambedkar Veedhi, Bangalore 560001, India.
authors.forename: T M
authors.initials: TM
authors.lastname: Vishwanatha
authors.forename: N
authors.initials: N
authors.lastname: Narendra
authors.forename: Basab
authors.initials: B
authors.lastname: Chattopadhyay
authors.forename: Monika
authors.initials: M
authors.lastname: Mukherjee
authors.forename: Vommina V
authors.initials: VV
authors.lastname: Sureshbabu
mesh_terms: D017607:Aluminum Compounds / Q000737:chemistry*; D004952:Esters; D018020:Lithium Compounds / Q000737:chemistry*; D008958:Models, Molecular; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry*; D018036:Selenium Compounds / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D017607:Aluminum Compounds; D004952:Esters; D018020:Lithium Compounds; D010455:Peptides; D018036:Selenium Compounds