title: Preliminary report of tolvaptan treatment in Japanese patients with heart failure.
abstract: While diuretic drugs are commonly used in patients with congestive heart failure, the efficacy of their long-term use still remains controversial. Recently, a new class of diuretics, vasopressin receptor 2 antagonists, has been launched, and tolvaptan is one such drug. We describe our initial experience with this novel agent. Tolvaptan is potentially useful for treatment of heart failure patients with fluid overload who are refractory to conventional diuretic therapies.
authors.affiliation: Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Semba
authors.forename: Koichiro
authors.initials: K
authors.lastname: Kinugawa
authors.forename: Norihiko
authors.initials: N
authors.lastname: Takeda
authors.forename: Taro
authors.initials: T
authors.lastname: Shiga
authors.forename: Go
authors.initials: G
authors.lastname: Nishimura
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Inajima
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Uchino
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Iwata
authors.forename: Eriko
authors.initials: E
authors.lastname: Hasumi
authors.forename: Hajime
authors.initials: H
authors.lastname: Abe
authors.forename: Yumiko
authors.initials: Y
authors.lastname: Terada
authors.forename: Akihiko
authors.initials: A
authors.lastname: Yonenaga
authors.forename: Yasunobu
authors.initials: Y
authors.lastname: Hirata
authors.forename: Ryozo
authors.initials: R
authors.lastname: Nagai
mesh_terms: D000368:Aged; D065092:Antidiuretic Hormone Receptor Antagonists; D001552:Benzazepines / Q000627:therapeutic use*; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D000077602:Tolvaptan
chemical_list: D065092:Antidiuretic Hormone Receptor Antagonists; D001552:Benzazepines; D000077602:Tolvaptan