title: Correlates of resistin in children with chronic kidney disease: the chronic kidney disease in children cohort.
abstract: OBJECTIVE
  To test the hypothesis that resistin is associated with insulin resistance and inflammation in pediatric patients with chronic kidney disease (CKD).
  
  
  METHODS
  This study is a cross-sectional analysis of 319 children in the Chronic Kidney Disease in Children cohort, a large cohort of children with stage II-IV CKD. Univariate and multivariate regression modeling was used to evaluate the association of serum resistin level with glomerular filtration rate (GFR), demographic data, and cardiovascular risk factors, including inflammatory cytokines, insulin resistance, and serum lipids.
  
  
  RESULTS
  In univariate analyses, serum resistin level was negatively correlated with GFR (P < .01). Increased serum resistin was associated with elevated inflammatory cytokines, including interleukin (IL)-6 (P < .01), IL-10 (P < .01), and tumor necrosis factor-α (P < .01). Resistin level was not associated with insulin resistance, although it was positively correlated with serum triglycerides (P < .01) and negatively correlated with high-density lipoprotein cholesterol (P < .01). In multivariate analysis, GFR (β = -0.01; P < .001), IL-6 (β = 0.18; P < .001), IL-10 (β = 0.09; P = .01), and pubertal status (β = 0.18; P < .01) were significantly associated with serum resistin level.
  
  
  CONCLUSIONS
  These results indicate that serum resistin level increases with GFR decline and is involved in the inflammatory milieu present in CKD.
authors.affiliation: Division of Nephrology and Hypertension, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
authors.forename: Edward
authors.initials: E
authors.lastname: Nehus
authors.forename: Susan
authors.initials: S
authors.lastname: Furth
authors.forename: Bradley
authors.initials: B
authors.lastname: Warady
authors.forename: Mark
authors.initials: M
authors.lastname: Mitsnefes
mesh_terms: D000293:Adolescent; D002648:Child; D015331:Cohort Studies; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007249:Inflammation; D007333:Insulin Resistance; D016753:Interleukin-10 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D051436:Renal Insufficiency, Chronic / Q000097:blood* / Q000503:physiopathology; D052243:Resistin / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D015850:Interleukin-6; D008055:Lipids; D052243:Resistin; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10