title: Hydrothermal synthesis of a highly sensitive T2-weigthed MRI contrast agent: zinc-doped superparamagnetic iron oxide nanocrystals.
abstract: A highly efficient hydrothermal strategy for the synthesis of zinc-doped superparamagnetic iron oxide nanocrystals (SPION:Zn) with lower toxicity and improved sensitivity has been demonstrated. The saturation magnetizations of as-synthesized SPION:Zn were demonstrated to be Zn-dependent and could be tuned from 41.88 emu/g to 79.23 emu/g by changing the amount of Zn. As-synthesized hydrophobic SPION:Zn could be efficiently transferred into water phase through a ultrasonic process with the assistance of cetyltrimethylammonium bromide (CTAB) surfactant. As-obtained CTAB stabilized SPION:Zn was exploited as a MR enhanced contrast agent, and its T2 relaxivity coefficient (r2) was found to be as high as 342.09 mM(-1)s(-1).
authors.affiliation: State Key Laboratory of High performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, People's Republic of China.
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
authors.forename: Wenbo
authors.initials: W
authors.lastname: Bu
authors.forename: Chunhua
authors.initials: C
authors.lastname: Lu
authors.forename: Gaoxiang
authors.initials: G
authors.lastname: Chen
authors.forename: Moying
authors.initials: M
authors.lastname: Chen
authors.forename: Xincheng
authors.initials: X
authors.lastname: Shen
authors.forename: Rui
authors.initials: R
authors.lastname: Liu
authors.forename: Jianlin
authors.initials: J
authors.lastname: Shi
mesh_terms: D003287:Contrast Media; D005290:Ferric Compounds / Q000737:chemistry*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008280:Magnetics; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles; D015032:Zinc / Q000737:chemistry*
chemical_list: D003287:Contrast Media; D005290:Ferric Compounds; C000499:ferric oxide; D015032:Zinc