title: The use of TachoSil for the prevention of postoperative complications after groin dissection in cases of gynecologic malignancy.
abstract: OBJECTIVE
  To evaluate the effect of TachoSil in preventing postoperative complications after groin dissection performed for primary or recurrent gynecologic malignancy.
  
  
  METHODS
  In a case-control analysis, the incidence of postoperative complications-including lymphocyst formation, wound breakdown and/or infection, and chronic lymphedema-was examined among 8 patients who received TachoSil and 16 controls (standard technique) treated for vulvar cancer or recurrent ovarian/breast cancer at San Gerardo Hospital, Monza, Italy, from 2008 to 2011.
  
  
  RESULTS
  Thirty-eight inguinal dissections were performed in the 24 patients. Bilateral groin dissection was performed in 14 patients (n=4 in the study group; n=10 in the control group). Patients in the study group had a lower mean daily drainage volume than those in the control group (133 mL [range, 50-356 mL] vs 320 mL [range, 67-472 mL]; P<0.001) and a lower incidence of lymphocyst requiring drainage (25.0% vs 62.5%), cellulitis (12.0% vs 25.0%), and wound infection (0.0% vs 25.0%).
  
  
  CONCLUSIONS
  The use of TachoSil seems to be effective in reducing the rate of postoperative complications after inguinofemoral lymphadenectomy in cases of gynecologic malignancy.
authors.affiliation: Department of Obstetrics and Gynecology, University of Milano-Bicocca, San Gerardo Hospital, Monza, Italy. alessandro.buda@fastwebnet.it
authors.forename: Alessandro
authors.initials: A
authors.lastname: Buda
authors.forename: Robert
authors.initials: R
authors.lastname: Fruscio
authors.forename: Cecilia
authors.initials: C
authors.lastname: Pirovano
authors.forename: Mauro
authors.initials: M
authors.lastname: Signorelli
authors.forename: Marta
authors.initials: M
authors.lastname: Betti
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Milani
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D019072:Antibiotic Prophylaxis; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery; D016022:Case-Control Studies; D002481:Cellulitis / Q000209:etiology / Q000517:prevention & control; D004322:Drainage; D004338:Drug Combinations; D005260:Female; D005340:Fibrinogen / Q000627:therapeutic use*; D006119:Groin; D006801:Humans; D008197:Lymph Node Excision / Q000009:adverse effects*; D008209:Lymphedema / Q000209:etiology / Q000517:prevention & control; D008210:Lymphocele / Q000209:etiology / Q000517:prevention & control; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000473:pathology* / Q000601:surgery; D015503:Surgical Sponges; D013529:Surgical Wound Dehiscence / Q000209:etiology / Q000517:prevention & control; D013530:Surgical Wound Infection / Q000209:etiology / Q000517:prevention & control; D013917:Thrombin / Q000627:therapeutic use*; D014846:Vulvar Neoplasms / Q000473:pathology* / Q000601:surgery
chemical_list: D004338:Drug Combinations; C518955:TachoSil; D005340:Fibrinogen; D013917:Thrombin