title: Selective thioether macrocyclization of peptides having the N-terminal 2-chloroacetyl group and competing two or three cysteine residues in translation.
abstract: The mode of thioether macrocyclization of peptides containing an N-terminal 2-chloroacetyl group and two or three competing cysteine residues at downstream positions has been extensively studied, leading to a strategy for designated formation of overlapping-bicyclic peptides or dumbbell-type bicyclic peptides.
authors.affiliation: Department of Chemistry and Biotechnology, Graduate School of Engineering, the University of Tokyo, 7-3-1 Hongo, Tokyo 113-8656, Japan.
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Iwasaki
authors.forename: Yuki
authors.initials: Y
authors.lastname: Goto
authors.forename: Takayuki
authors.initials: T
authors.lastname: Katoh
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Suga
mesh_terms: D000595:Amino Acid Sequence; D003500:Cyclization; D003545:Cysteine / Q000737:chemistry*; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism*; D014176:Protein Biosynthesis; D015202:Protein Engineering / Q000379:methods*; D013440:Sulfides / Q000737:chemistry*
chemical_list: D010455:Peptides; D013440:Sulfides; D003545:Cysteine