title: Thrombophilia among Chinese women with venous thromboembolism during pregnancy.
abstract: OBJECTIVE
  To assess the prevalence of thrombophilia among Chinese women with venous thromboembolism (VTE) developed during pregnancy.
  
  
  METHODS
  Based on information from a tertiary teaching unit, all recorded cases of deep vein thrombosis (DVT) and pulmonary embolism (PE) during pregnancy diagnosed between 1997 and 2005, were assessed for prevalence of thrombophilia. Fifty-five healthy women, who had at least one normal pregnancy but without any previous history of VTE, were recruited as controls.
  
  
  RESULTS
  A total of 44 subjects completed thrombophilia screening, of whom 5 (11%) were confirmed to have thrombophilia [protein C (PC) deficiency (2), protein S (PS) deficiency (1), combined PC & PS deficiency (1) and antithrombin III deficiency (1)]. Homozygous 5,10-methylenetetrahydrofolate reductase (C677T) gene mutation was found in 6 (14%) subjects but not in the controls. There was no antiphospholipid syndrome, activated PC resistance, factor V Leiden or prothrombin gene mutations.
  
  
  CONCLUSIONS
  In the Chinese population, PS and PC deficiencies are common thrombophilia for VTE during pregnancy and thrombophilia screening should be recommended in all pregnant women who suffer from VTE.
authors.affiliation: Department of Obstetrics and Gynecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, N.T., Hong Kong SAR, China. tamwh@cuhk.edu.hk
authors.forename: Wing-Hung
authors.initials: WH
authors.lastname: Tam
authors.forename: Margaret Heung-Ling
authors.initials: MH
authors.lastname: Ng
authors.forename: Alice Ka-Wah
authors.initials: AK
authors.lastname: Yiu
authors.forename: Kin-Mang
authors.initials: KM
authors.lastname: Lau
authors.forename: Gregory Yin-Ming
authors.initials: GY
authors.lastname: Cheng
authors.forename: Chi-Yin
authors.initials: CY
authors.lastname: Li
mesh_terms: D020016:Activated Protein C Resistance / Q000453:epidemiology; D000328:Adult; D020152:Antithrombin III Deficiency / Q000453:epidemiology; D044466:Asian People / Q000208:ethnology; D016022:Case-Control Studies; D015331:Cohort Studies; D017931:DNA Primers / Q000737:chemistry; D005165:Factor V / Q000235:genetics; D005260:Female; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics; D009154:Mutation; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic; D015995:Prevalence; D011446:Prospective Studies; D020151:Protein C Deficiency / Q000453:epidemiology; D018455:Protein S Deficiency / Q000453:epidemiology; D011516:Prothrombin / Q000235:genetics; D011655:Pulmonary Embolism / Q000453:epidemiology; D019851:Thrombophilia / Q000453:epidemiology*; D020246:Venous Thrombosis / Q000453:epidemiology*
chemical_list: D017931:DNA Primers; C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin; C573423:MTHFR protein, human; D042965:Methylenetetrahydrofolate Reductase (NADPH2)