title: The effects of prenatal alcohol exposure on the developmental retina of mice.
abstract: OBJECTIVE
  Our aim is to investigate the effects of prenatal alcohol exposure (PAE) on the development of retinal bipolar and horizontal cells.
  
  
  METHODS
  The alterations of the retinal bipolar and horizontal cells in P7, P14 and P30 mice were observed after PAE, with immunofluorescent labeling and DiI diolistic assay.
  
  
  RESULTS
  The retinal development of filial pups was affected by PAE in a dose-dependent and long-term manner. The number of bipolar cells of alcohol groups was significantly lower than that of the control, and the dendritic receptive field of horizontal cells was also significantly smaller than those of the control groups (P < 0.01).
  
  
  CONCLUSIONS
  PAE was able to cause retarded development of pup retinal neural cells.
authors.affiliation: Institute of Neurobiology of Nursing College, Henan University, Kaifeng 475004, People’s Republic of China.
authors.forename: Jie-Xin
authors.initials: JX
authors.lastname: Deng
authors.forename: Xi
authors.initials: X
authors.lastname: Liu
authors.forename: Jian-Feng
authors.initials: JF
authors.lastname: Zang
authors.forename: Hong-En
authors.initials: HE
authors.lastname: Huang
authors.forename: Yan
authors.initials: Y
authors.lastname: Xi
authors.forename: Hong
authors.initials: H
authors.lastname: Zheng
authors.forename: Huan-Ling
authors.initials: HL
authors.lastname: Yao
authors.forename: Dong-Ming
authors.initials: DM
authors.lastname: Yu
authors.forename: Jin-Bo
authors.initials: JB
authors.lastname: Deng
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000009:adverse effects* / Q000097:blood; D005260:Female; D063647:Fetal Alcohol Spectrum Disorders / Q000473:pathology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000473:pathology*; D012160:Retina / Q000002:abnormalities*; D051245:Retinal Bipolar Cells / Q000187:drug effects* / Q000473:pathology; D051248:Retinal Horizontal Cells / Q000187:drug effects* / Q000473:pathology
chemical_list: D000431:Ethanol