title: Automatic fiber bundle segmentation in massive tractography datasets using a multi-subject bundle atlas.
abstract: This paper presents a method for automatic segmentation of white matter fiber bundles from massive dMRI tractography datasets. The method is based on a multi-subject bundle atlas derived from a two-level intra-subject and inter-subject clustering strategy. This atlas is a model of the brain white matter organization, computed for a group of subjects, made up of a set of generic fiber bundles that can be detected in most of the population. Each atlas bundle corresponds to several inter-subject clusters manually labeled to account for subdivisions of the underlying pathways often presenting large variability across subjects. An atlas bundle is represented by the multi-subject list of the centroids of all intra-subject clusters in order to get a good sampling of the shape and localization variability. The atlas, composed of 36 known deep white matter bundles and 47 superficial white matter bundles in each hemisphere, was inferred from a first database of 12 brains. It was successfully used to segment the deep white matter bundles in a second database of 20 brains and most of the superficial white matter bundles in 10 subjects of the same database.
authors.affiliation: I(2)BM, CEA, Gif-sur-Yvette, France. pamela.guevara@gmail.com
authors.forename: P
authors.initials: P
authors.lastname: Guevara
authors.forename: D
authors.initials: D
authors.lastname: Duclap
authors.forename: C
authors.initials: C
authors.lastname: Poupon
authors.forename: L
authors.initials: L
authors.lastname: Marrakchi-Kacem
authors.forename: P
authors.initials: P
authors.lastname: Fillard
authors.forename: D
authors.initials: D
authors.lastname: Le Bihan
authors.forename: M
authors.initials: M
authors.lastname: Leboyer
authors.forename: J
authors.initials: J
authors.lastname: Houenou
authors.forename: J-F
authors.initials: JF
authors.lastname: Mangin
mesh_terms: D000716:Anatomy, Artistic; D001271:Atlases as Topic; D001921:Brain / Q000166:cytology*; D056324:Diffusion Tensor Imaging; D006801:Humans; D009412:Nerve Fibers / Q000648:ultrastructure*; D009413:Nerve Fibers, Myelinated / Q000648:ultrastructure*; D009434:Neural Pathways / Q000166:cytology*