title: Nanostructured Ag platforms as biosensors of nucleobase chains.
abstract: Nanostructured Ag platforms have been obtained by simple chemical procedure and characterized by AFM (atomic force microscopy) measurements, for use in biosensing by means of SERS (surface-enhanced Raman scattering) spectroscopy. The SERS efficiency of these substrates has been verified by microRaman measurements on small RNA chains with different nucleobase content, showing sensitivity near attomole level. It is our opinion that these metal substrates may be widely used as appropriate sensors for detecting biomolecules in many applications concerning medical diagnostics, pharmacological research and nanomaterials technology.
authors.affiliation: Department of Chemistry, University of Florence, via della Lastruccia 3, 50019 Sesto Fiorentino (FI), Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Muniz-Miranda
authors.forename: Cristina
authors.initials: C
authors.lastname: Gellini
authors.forename: Pier Remigio
authors.initials: PR
authors.lastname: Salvi
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Schettino
authors.forename: Marco
authors.initials: M
authors.lastname: Pagliai
authors.forename: Massimo
authors.initials: M
authors.lastname: Innocenti
mesh_terms: D000327:Adsorption; D015374:Biosensing Techniques; D003102:Colloids / Q000737:chemistry; D053768:Metal Nanoparticles / Q000737:chemistry*; D035683:MicroRNAs / Q000737:chemistry*; D018625:Microscopy, Atomic Force / Q000379:methods; D009711:Nucleotides / Q000737:chemistry*; D012834:Silver / Q000737:chemistry*; D013059:Spectrum Analysis, Raman / Q000379:methods
chemical_list: D003102:Colloids; D035683:MicroRNAs; D009711:Nucleotides; D012834:Silver