title: [Effectiveness of aromatase inhibitors in comparison with metformin for neoadjuvant treatment in patients with endometrial cancer].
abstract: We compared the efficacy of endometrial cancer neoadjuvant treatment in 38 patients receiving nonsteroid (letrozol, anastrozol) or steroid (ekzemestan) aromatase inhibitors and 12 patients receiving metformin. The changes in glucose metabolism were revealed in 26.3% of patients treated with aromatase inhibitors and 16.7% of patients treated with metformin. However, comparison of endometrial thickness (M-echo signal) data, postoperative data on favorable differentiation grade changes rate and proliferative activity (Ki-67 expression) revealed the superiority of 2-4 weeks aromatase inhibitors course in comparison with 2-9 (average 5.3 +/- 0.7) weeks metformin treatment.
authors.forename: L M
authors.initials: LM
authors.lastname: Bershteĭn
authors.forename: S Ia
authors.initials: SIa
authors.lastname: Maksimov
authors.forename: M A
authors.initials: MA
authors.lastname: Danilova
authors.forename: É D
authors.initials: ÉD
authors.lastname: Gershfel'd
authors.forename: M P
authors.initials: MP
authors.lastname: Boiarkina
authors.forename: A S
authors.initials: AS
authors.lastname: Khadzhimba
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Kovalevskiĭ
authors.forename: E A
authors.initials: EA
authors.lastname: Turkevich
authors.forename: I E
authors.initials: IE
authors.lastname: Meshkova
mesh_terms: D000328:Adult; D000368:Aged; D000077384:Anastrozole; D000730:Androstadienes / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D047072:Aromatase Inhibitors / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000032:analysis; D016889:Endometrial Neoplasms / Q000188:drug therapy* / Q000601:surgery; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D019394:Ki-67 Antigen / Q000032:analysis; D000077289:Letrozole; D008687:Metformin / Q000627:therapeutic use*; D008875:Middle Aged; D020360:Neoadjuvant Therapy / Q000379:methods*; D060787:Neoplasm Grading; D009570:Nitriles / Q000008:administration & dosage; D016896:Treatment Outcome; D014230:Triazoles / Q000008:administration & dosage
chemical_list: D000730:Androstadienes; D000970:Antineoplastic Agents; D018931:Antineoplastic Agents, Hormonal; D047072:Aromatase Inhibitors; D014408:Biomarkers, Tumor; D007004:Hypoglycemic Agents; D019394:Ki-67 Antigen; D009570:Nitriles; D014230:Triazoles; D000077384:Anastrozole; D000077289:Letrozole; D008687:Metformin; D005947:Glucose; C056516:exemestane