title: A translocation t(5;15)(q15;q11-13) infant case with acute lymphoblastic leukemia and literature review: prognosis implications.
abstract: Infant acute lymphoblastic leukemia (ALL) represents poor prognosis despite intensive chemotherapy. Rearrangements of chromosome 11q23 are not observed in 34% of the cases. Infant ALL patients with t(5;15)(p15;q11-13) are rare and sporadic. In large series of infant ALL studies, 6 patients have been reported. We present a new case of an infant ALL patient with t(5;15)(p15;q11-13), and a literature review. Considering the data provided by our case and previous reports, we reinforce that this chromosomal abnormality is characteristic of ALL patients under 12 months of age sharing break point in 5p15 and 15q11-13 and strengthen the existence of an infant ALL subgroup characterized by pre-B L1 ALL, CD10-positive, complete remission (100%), and event-free survival (71%), with a relatively good prognosis and clearly less severe than the 11q23 rearrangement cases. This abnormality can be considered a recurrent abnormality on this nosologic group.
authors.affiliation: Unidad de Citogenética/Servicio de Hematología Oncología Pediátrica, División de Pediatría, Nuevo Hospital Civil Dr Juan I Menchaca, Guadalajara, Jalisco, México. alcoronar@gmail.com
authors.forename: Alfredo
authors.initials: A
authors.lastname: Corona-Rivera
authors.forename: Lucina
authors.initials: L
authors.lastname: Bobadilla-Morales
authors.forename: Rosa Margarita
authors.initials: RM
authors.lastname: Cruz-Osorio
authors.forename: Citlalli
authors.initials: C
authors.lastname: Ortega-de-la-Torre
authors.forename: Sergio
authors.initials: S
authors.lastname: Gallegos-Castorena
authors.forename: Fernando
authors.initials: F
authors.lastname: Sánchez-Zubieta
mesh_terms: D002884:Chromosomes, Human, Pair 15; D002895:Chromosomes, Human, Pair 5; D005260:Female; D006801:Humans; D007223:Infant; D015260:Neprilysin / Q000032:analysis; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics* / Q000401:mortality; D011379:Prognosis; D014178:Translocation, Genetic
chemical_list: D015260:Neprilysin