title: Desmettianosides A and B, bisdesmosidic furostanol saponins with molluscicidal activity from Yucca desmettiana.
abstract: Bioactivity-guided separation of the aqueous methanolic extract of Yucca desmettiana leaves, which in a preliminary screening exhibited significant molluscicidal activity, led to the isolation and structure elucidation of two new steroidal saponins (1 and 2). The structures of desmettianosides A and B, identified as bisdesmosidic furostanol glycosides with six and five sugar units, respectively, were established by detailed spectroscopic analyses of their NMR and MS data. Compounds 1 and 2 exhibited high molluscicidal activity against Biomphalaria alexandrina snails with LC100 values of 6 and 11 mg/L, respectively.
authors.affiliation: Department of Pharmacognosy & Chemistry of Natural Products, School of Pharmacy, University of Athens, Panepistimiopolis Zografou, Athens 15771, Greece.
authors.forename: Yasser
authors.initials: Y
authors.lastname: Diab
authors.forename: Efstathia
authors.initials: E
authors.lastname: Ioannou
authors.forename: Ahmed
authors.initials: A
authors.lastname: Emam
authors.forename: Constantinos
authors.initials: C
authors.lastname: Vagias
authors.forename: Vassilios
authors.initials: V
authors.lastname: Roussis
mesh_terms: D000818:Animals; D001700:Biomphalaria / Q000187:drug effects; D000432:Methanol / Q000737:chemistry; D008975:Molluscacides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D014867:Water / Q000737:chemistry; D027623:Yucca / Q000737:chemistry*
chemical_list: D008975:Molluscacides; D012503:Saponins; C511987:bisdesmoside; D014867:Water; D000432:Methanol