title: Functions of the Salmonella pathogenicity island 2 (SPI-2) type III secretion system effectors.
abstract: Salmonella enterica serovars cause severe disease in humans, such as gastroenteritis and typhoid fever. The bacteria are able to invade and replicate within host cells, including epithelial cells and macrophages. Pathogenesis of Salmonella is facilitated by a type III secretion system (T3SS) encoded by genes of Salmonella pathogenicity island 2 (SPI-2). Intracellular replication occurs in a specialized membrane compartment, the Salmonella-containing vacuole (SCV), and depends on translocation of approximately 30 effector proteins via the SPI-2 T3SS into the host endomembrane system and cytoplasm. In this review we discuss the many different functions of these effectors, which range from maintaining the integrity of the SCV and its juxtanuclear location, to interference with the host cytoskeleton and immune signalling.
authors.affiliation: Section of Microbiology, Centre for Molecular Microbiology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ, UK.
authors.forename: Rita
authors.initials: R
authors.lastname: Figueira
authors.affiliation: Section of Microbiology, Centre for Molecular Microbiology and Infection, Imperial College London, Armstrong Road, London SW7 2AZ, UK.
authors.forename: David W
authors.initials: DW
authors.lastname: Holden
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D058947:Bacterial Secretion Systems; D002462:Cell Membrane / Q000473:pathology; D003599:Cytoskeleton / Q000382:microbiology; D044404:Genomic Islands; D012480:Salmonella Infections / Q000382:microbiology; D019779:Salmonella enterica / Q000235:genetics / Q000472:pathogenicity*; D014617:Vacuoles / Q000382:microbiology
chemical_list: D001426:Bacterial Proteins; D058947:Bacterial Secretion Systems