title: Reversion-inducing cysteine-rich protein with Kazal motif (RECK) expression: an independent prognostic marker of survival in colorectal cancer.
abstract: Patient prognosis in colorectal cancer is determined as in most solid cancers by the extent of local invasion and the presence of lymph node and distant metastases. The invasive potential of a tumor depends on the ability to degrade extracellular matrix proteins, for example, by matrix metalloproteinases. An important inhibitor of matrix metalloproteinases is reversion-inducing cysteine-rich protein with Kazal motifs (RECK), a membrane-anchored glycoprotein. This study investigated the prognostic relevance of RECK expression in colorectal cancer in a cohort of 283 patients. Analysis of immunohistochemical tissue microarray data showed that RECK protein levels did not seem to correlate with clinicopathologic parameters (Spearman rank correlation coefficients between -0.14 and -0.18) and that decreased RECK expression was an independent prognostic factor of poor survival, with a mean survival of 70 months in RECK-negative (146 cases) versus 97 months in RECK-positive patients (137 cases) (log-rank test, P = .002).
authors.affiliation: Institute of Pathology, University of Heidelberg, and National Center of Tumor Diseases, Im Neuenheimer Feld 220/221, 69120 Heidelberg, Germany.
authors.forename: Albrecht
authors.initials: A
authors.lastname: Stenzinger
authors.forename: Moritz
authors.initials: M
authors.lastname: von Winterfeld
authors.forename: Anja
authors.initials: A
authors.lastname: Rabien
authors.forename: Arne
authors.initials: A
authors.lastname: Warth
authors.forename: Carsten
authors.initials: C
authors.lastname: Kamphues
authors.forename: Manfred
authors.initials: M
authors.lastname: Dietel
authors.forename: Wilko
authors.initials: W
authors.lastname: Weichert
authors.forename: Frederick
authors.initials: F
authors.lastname: Klauschen
authors.forename: Daniel
authors.initials: D
authors.lastname: Wittschieber
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism*; D002277:Carcinoma / Q000378:metabolism* / Q000401:mortality; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000401:mortality; D005260:Female; D058851:GPI-Linked Proteins / Q000378:metabolism*; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D058851:GPI-Linked Proteins; C115460:RECK protein, human