title: Nasal epithelium integrity, environmental stressors, and allergic sensitization: a biomarker study in adolescents.
abstract: Changes in the airways epithelium caused by environmental insults might play a role in the development of allergic rhinitis. We measured albumin and Clara cell protein (CC16) in the nasal lavage fluid (NALF) from 474 adolescents (263 girls and 211 boys). The NALF CC16/albumin ratio, integrating the permeability and cellular integrity of the nasal epithelium, decreased mostly with time spent in chlorinated pools. In boys, a lower CC16/albumin ratio in NALF was associated with an increased risk of house dust mite sensitization. The results suggest that the CC16/albumin ratio in NALF can be used to detect nasal epithelium alterations linked to allergic sensitization.
authors.affiliation: Louvain Centre for Toxicology and Applied Pharmacology, Faculty of Medicine, Catholic University of Louvain, Brussels, Belgium.
authors.forename: Antonia
authors.initials: A
authors.lastname: Sardella
authors.forename: Catherine
authors.initials: C
authors.lastname: Voisin
authors.forename: Marc
authors.initials: M
authors.lastname: Nickmilder
authors.forename: Xavier
authors.initials: X
authors.lastname: Dumont
authors.forename: Isabella
authors.initials: I
authors.lastname: Annesi-Maesano
authors.forename: Alfred
authors.initials: A
authors.lastname: Bernard
mesh_terms: D000293:Adolescent; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology / Q000378:metabolism*; D007073:Immunoglobulin E / Q000097:blood; D008297:Male; D017817:Nasal Lavage Fluid / Q000737:chemistry; D009297:Nasal Mucosa / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D010539:Permeability; D011058:Pollen / Q000276:immunology; D039981:Pyroglyphidae / Q000276:immunology; D012044:Regression Analysis; D012709:Serum Albumin / Q000378:metabolism; D014508:Urea / Q000097:blood; D014598:Uteroglobin / Q000378:metabolism*
chemical_list: D015415:Biomarkers; C556389:SCGB1A1 protein, human; D012709:Serum Albumin; D007073:Immunoglobulin E; D014508:Urea; D014598:Uteroglobin