title: Primary progressive aphasia and transient global amnesia.
abstract: OBJECTIVE
  To describe 3 patients with a history of transient global amnesia (TGA) who developed primary progressive aphasia (PPA).
  
  
  METHODS
  Case series.
  
  
  METHODS
  Tertiary care center.
  
  
  METHODS
  The study included 3 patients who presented to the neurology clinic with language complaints.
  
  
  METHODS
  Presence of recurrent TGA and PPA.
  
  
  RESULTS
  Three patients with a history of TGA were subsequently diagnosed as having PPA. All patients had recurrent attacks of TGA. The diagnoses of PPA were supported by speech pathology evaluations, neuropsychometric testing results, and imaging findings. Positron emission tomography revealed left posterior frontal hypometabolism in 1 patient and predominantly left temporal parietal hypometabolism in 1 patient, while single-photon emission computed tomography demonstrated decreased perfusion in the anterior left temporal and frontal lobes in the third patient.
  
  
  CONCLUSIONS
  There may be a relationship between recurrent TGA and the development of PPA.
authors.affiliation: Department of Neurology, Mayo Clinic, 200 1st St SW, Rochester, MN 55905, USA.
authors.forename: Jonathan
authors.initials: J
authors.lastname: Graff-Radford
authors.forename: Keith A
authors.initials: KA
authors.lastname: Josephs
mesh_terms: D000368:Aged; D020236:Amnesia, Transient Global / Q000145:classification / Q000150:complications* / Q000523:psychology; D018888:Aphasia, Primary Progressive / Q000145:classification / Q000209:etiology* / Q000523:psychology; D001284:Atrophy; D002540:Cerebral Cortex / Q000503:physiopathology; D003072:Cognition Disorders / Q000209:etiology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D012008:Recurrence