title: CATALYTIC DYNAMIC RESOLUTION APPLIED TO THE SYNTHESIS OF 2,6-DISUBSTITUTED PIPERIDINES: PREPARATION OF (+)-LUPETIDINE AND (-)-EPIDIHYDROPINIDINE.
abstract: The diastereoselective synthesis of trans-2,6-disubstituted piperidines has been rendered enantioselective by incorporating a catalytic dynamic resolution into the first alkylation step. The method has been applied to the synthesis of (-)-epidihydropinidine and (+)-trans-lupetidine.
authors.affiliation: Department of Chemistry and Biochemistry, University of Arkansas, 119 Chemistry, Fayetteville, Arkansas, USA 72701.
authors.forename: Timothy K
authors.initials: TK
authors.lastname: Beng
authors.forename: Robert E
authors.initials: RE
authors.lastname: Gawley