title: Finite element modelling of pulsatile blood flow in idealized model of human aortic arch: study of hypotension and hypertension.
abstract: A three-dimensional computer model of human aortic arch with three branches is reproduced to study the pulsatile blood flow with Finite Element Method. In specific, the focus is on variation of wall shear stress, which plays an important role in the localization and development of atherosclerotic plaques. Pulsatile pressure pulse is used as boundary condition to avoid flow entry development, and the aorta walls are considered rigid. The aorta model along with boundary conditions is altered to study the effect of hypotension and hypertension. The results illustrated low and fluctuating shear stress at outer and inner wall of aortic arch, proximal wall of branches, and entry region. Despite the simplification of aorta model, rigid walls and other assumptions results displayed that hypertension causes lowered local wall shear stresses. It is the sign of an increased risk of atherosclerosis. The assessment of hemodynamics shows that under the flow regimes of hypotension and hypertension, the risk of atherosclerosis localization in human aorta may increase.
authors.affiliation: Faculty of Technology, Lappeenranta University of Technology, Lappeenranta, Finland.
authors.forename: Paritosh
authors.initials: P
authors.lastname: Vasava
authors.forename: Payman
authors.initials: P
authors.lastname: Jalali
authors.forename: Mahsa
authors.initials: M
authors.lastname: Dabagh
authors.forename: Pertti J
authors.initials: PJ
authors.lastname: Kolari
mesh_terms: D001013:Aorta, Thoracic / Q000502:physiology*; D003324:Coronary Artery Disease / Q000503:physiopathology; D003326:Coronary Circulation / Q000502:physiology*; D020342:Finite Element Analysis; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D007022:Hypotension / Q000503:physiopathology*; D008955:Models, Cardiovascular; D011673:Pulsatile Flow / Q000502:physiology*; D012306:Risk; D013314:Stress, Mechanical