title: Short communication: adhesion pathways utilized by HIV-infected lymphocytes.
abstract: We recently reported a novel adhesion pathway in lymphocytes that is mediated by cyclin-dependent kinase (Cdk) 4 activity and mediates lymphocyte interactions with endothelial matrix. We now demonstrate that HIV-infected lymphocytes also use Cdk4 to mediate spontaneous adhesion to fibronectin and endothelial matrix. We further demonstrate that HIV-infected lymphocytes require Rap-1 activity for phorbol-stimulated adhesion. Understanding adhesion pathways used by HIV-infected lymphocytes may lead to interventions to regulate aberrant adhesion and migration.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Washington, Seattle, WA, USA.
authors.forename: Yu-hua
authors.initials: YH
authors.lastname: Chow
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.forename: Barbara
authors.initials: B
authors.lastname: Schwartz
authors.forename: John M
authors.initials: JM
authors.lastname: Harlan
authors.forename: Lynn M
authors.initials: LM
authors.lastname: Schnapp
mesh_terms: D002448:Cell Adhesion; D002478:Cells, Cultured; D051358:Cyclin-Dependent Kinase 4 / Q000378:metabolism*; D042783:Endothelial Cells / Q000502:physiology*; D005353:Fibronectins / Q000378:metabolism*; D006678:HIV / Q000472:pathogenicity*; D006801:Humans; D008214:Lymphocytes / Q000502:physiology* / Q000821:virology*
chemical_list: D005353:Fibronectins; C495900:CDK4 protein, human; D051358:Cyclin-Dependent Kinase 4