title: Interleukin-10 and interferon-gamma patterns during tuberculosis treatment: possible association with recurrence.
abstract: Interleukin (IL) 10 and interferon-gamma (IFN-) levels in induced sputum supernatants of 21 tuberculosis (TB) patients at diagnosis and during chemotherapy were correlated to recurrence rates. IL-10 decreased until day 60 of treatment (T60), and between T60 and T180 it increased again  in 7 cases (Pattern 1) and further decreased in 14 cases (Pattern 2). Follow-up of 69 months was performed in 20/21 cases; 6 had recurrence of TB, of which 5/7 (71%) had Pattern 1 and 1/13 (7.7%) Pattern 2 (OR 30.0, 95%CI 2.19411.3, P 0.0072). This was not observed for IFN-. High IL-10  levels at the end of treatment may function as a risk factor for TB recurrence.
authors.affiliation: Multidisciplinary Laboratory, Clementino Fraga Filho University Hospital, Institute of Thoracic Diseases, School of Medicine, Federal University of Rio de Janeiro, Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: P M
authors.initials: PM
authors.lastname: Lago
authors.forename: N
authors.initials: N
authors.lastname: Boéchat
authors.forename: D P
authors.initials: DP
authors.lastname: Migueis
authors.forename: A S
authors.initials: AS
authors.lastname: Almeida
authors.forename: L C
authors.initials: LC
authors.lastname: Lazzarini
authors.forename: M M
authors.initials: MM
authors.lastname: Saldanha
authors.forename: A L
authors.initials: AL
authors.lastname: Kritski
authors.forename: J L
authors.initials: JL
authors.lastname: Ho
authors.forename: J R
authors.initials: JR
authors.lastname: Lapa e Silva
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007371:Interferon-gamma / Q000276:immunology*; D016753:Interleukin-10 / Q000276:immunology*; D008297:Male; D012008:Recurrence; D012307:Risk Factors; D013183:Sputum / Q000276:immunology; D014376:Tuberculosis / Q000188:drug therapy / Q000276:immunology*; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents; D016753:Interleukin-10; D007371:Interferon-gamma