title: The normoglycemic first-degree relatives of patients with type 2 diabetes mellitus have low circulating omentin-1 and adiponectin levels.
abstract: OBJECTIVE
  It has been suggested that adipose-derived cytokines act as insulin sensitizers/insulin-mimetics and some others may induce insulin resistance. In order to elucidate the potential role of novel adipocytokines in the pre-diabetes states, circulating levels of novel adipocytokines were evaluated in first-degree relatives of subjects with type 2 diabetes mellitus (FDRs).
  
  
  METHODS
  Serum omentin-1, adiponectin and retinol-binding protein 4 (RBP4) levels were measured in 179 subjects (90 glucose tolerant FDRs and 89 age- and sex-matched healthy controls) using enzyme-linked immunosorbent assay (ELISA) methods.
  
  
  RESULTS
  There was no significant difference between the two groups regarding serum RBP4 concentrations. However, serum omentin-1 (median [interquartile range], 6.18 [4.06-11.52]ng/ml versus 10.50 [4.30-20.60]ng/ml, p=0.004) and adiponectin (mean±SD, 10.07±4.0 μg/ml versus 20.66±8.12 μg/ml, p<0.0001) levels were significantly lower in FDRs when compared with the controls. In multiple logistic regression analysis, FDRs showed a significant association with lower circulating omentin-1 and adiponectin levels, even after adjustments were made for age, sex, body mass index, blood pressure measures, and biochemical parameters including glucose status, lipid profile, insulin levels and HOMA-IR (OR=0.49, CI [0.30-0.79]; p=0.004 and OR=0.74, CI [0.67-0.82]; p<0.0001, respectively). However, FDRs did not show a significant association with serum RBP4 levels in different models of regression analyses.
  
  
  CONCLUSIONS
  The FDRs showed significant associations with lower omentin-1 and adiponectin levels. A potential role for these adipokines in the FDRs' increased risk of diabetes needs to be further elucidated.
authors.affiliation: Department of Endocrine and Metabolic Diseases, The Persian Gulf Tropical Medicine Research Center, Bushehr University of Medical Sciences, Bushehr 7514763448, Iran.
authors.forename: Samad
authors.initials: S
authors.lastname: Akbarzadeh
authors.forename: Iraj
authors.initials: I
authors.lastname: Nabipour
authors.forename: Majid
authors.initials: M
authors.lastname: Assadi
authors.forename: Ali
authors.initials: A
authors.lastname: Movahed
authors.forename: Seyed Mojtaba
authors.initials: SM
authors.lastname: Jafari
authors.forename: Niloofar
authors.initials: N
authors.lastname: Motamed
authors.forename: Habibollah
authors.initials: H
authors.lastname: Nazem
authors.forename: Mehrnoosh
authors.initials: M
authors.lastname: Haraghy
authors.forename: Abdolreza
authors.initials: A
authors.lastname: Pourbehi
authors.forename: Afshar
authors.initials: A
authors.lastname: Bargahi
authors.forename: Najmeh
authors.initials: N
authors.lastname: Hajian
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D016207:Cytokines / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005190:Family; D005260:Female; D058851:GPI-Linked Proteins / Q000097:blood; D005951:Glucose Tolerance Test; D006801:Humans; D037102:Lectins / Q000097:blood*; D008297:Male; D008875:Middle Aged
chemical_list: D052242:Adiponectin; D016207:Cytokines; D058851:GPI-Linked Proteins; C432397:ITLN1 protein, human; D037102:Lectins