title: Mechanism-based inactivation (MBI) of cytochrome P450 enzymes: structure-activity relationships and discovery strategies to mitigate drug-drug interaction risks.
authors.affiliation: Worldwide Medicinal Chemistry, Pfizer Global Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States.
authors.forename: Suvi T M
authors.initials: ST
authors.lastname: Orr
authors.forename: Sharon L
authors.initials: SL
authors.lastname: Ripp
authors.forename: T Eric
authors.initials: TE
authors.lastname: Ballard
authors.forename: Jaclyn L
authors.initials: JL
authors.lastname: Henderson
authors.forename: Dennis O
authors.initials: DO
authors.lastname: Scott
authors.forename: R Scott
authors.initials: RS
authors.lastname: Obach
authors.forename: Hao
authors.initials: H
authors.lastname: Sun
authors.forename: Amit S
authors.initials: AS
authors.lastname: Kalgutkar
mesh_terms: D000818:Animals; D001059:Apoproteins / Q000378:metabolism; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000737:chemistry / Q000378:metabolism*; D055808:Drug Discovery; D004347:Drug Interactions; D006418:Heme / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D010599:Pharmacokinetics; D013329:Structure-Activity Relationship; D013997:Time Factors
chemical_list: D001059:Apoproteins; D065607:Cytochrome P-450 Enzyme Inhibitors; D006418:Heme; D003577:Cytochrome P-450 Enzyme System