title: Two new nortriterpenoid saponins from Salicornia bigelovii Torr. and their cytotoxic activity.
abstract: Investigation of characteristic constituents of Salicornia bigelovii Torr. led to isolation of two new 30-nortriterpenoid glycosides, Bigelovii A (1), Bigelovii B (2), together with two known 30-nortriterpenoid glycosides 3-4 and three known oleanane-type triterpenoid glycosides 5-7. The structures of new compounds were elucidated by extensive 1D and 2D NMR, and MS spectroscopic analysis, and chemical evidences. All compounds were isolated for the first time from Chenopodiaceae. Thus compounds 1-4 were evaluated for their cytotoxicity and compouds 1, 3 showed moderate activity against four cell lines, HL-60 (promyelocytic leukemia), MCF-7 (breast carcinoma), HepG2 (liver carcinoma) and A549 (lung carcinoma), with IC(50) values of 6.18, 78.08, 13.64 and >100μM for 1; 31.87, >100, ~100, >100μM for 3, respectively.
authors.affiliation: Institute of Botany, Jiangsu Province and Chinese Academy of Sciences/Nanjing Botanical Garden Mem. Sun Yat-Sen, Nanjing 210014, PR China.
authors.forename: Qi-zhi
authors.initials: QZ
authors.lastname: Wang
authors.forename: Xiao-feng
authors.initials: XF
authors.lastname: Liu
authors.forename: Yu
authors.initials: Y
authors.lastname: Shan
authors.forename: Fu-qin
authors.initials: FQ
authors.lastname: Guan
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.forename: Xiang-yun
authors.initials: XY
authors.lastname: Wang
authors.forename: Ming
authors.initials: M
authors.lastname: Wang
authors.forename: Xu
authors.initials: X
authors.lastname: Feng
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D045744:Cell Line, Tumor; D019663:Chenopodiaceae / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D012503:Saponins; D014315:Triterpenes; C575123:bigelovii A; C575124:bigelovii B