title: cTNM vs. pTNM: the effect of not applying ultrasonography in the identification of cervical nodal disease.
abstract: Accurate clinical staging of oral squamous cell cancer can be quite difficult to achieve especially if nodal involvement is identified. Radiologically-assisted clinical staging is more accurate and informs the clinician of loco-regional and distant metastasis.In this study, we compared clinical TNM (cTNM) staging (not including ultrasonography) to pathological TNM (pTNM) staging in 245 patients presenting with carcinoma of the oral cavity and the oro-pharyngeal region. Tumour size differences and nodal involvement were highlighted. US reports of the neck were then added to the clinical staging and results compared.Tumour size was clinically underestimated in 4 T1, 2 T2 and 2 T3 oral diseases. Also 20 patients that were reported as nodal disease free had histological proven N1 or N2 nodal involvement; while 3 patients with cTNM showing N1 disease had histologically proven N2 disease.Overall the agreement between the 2 systems per 1 site was 86.6% (Kappa agreement = 0.80), per 2 sites 90.0% (Kappa agreement = 0.68) and per 3 sites 90.5% (Kappa agreement 0.62).An accurate clinical staging is of an utmost importance. It is the corner stone in which the surgical team build the surgical treatment plan and decide whether an adjuvant therapy is required to deal with any possible problem that might arise. The failure to achieve an accurate staging may lead to incomplete surgical planning and hence unforeseen problems that may adversely affect the patient's survival.
authors.affiliation: UCL Department of Surgery, University College London, London, UK. waseem_wk1@yahoo.co.uk
authors.forename: Waseem
authors.initials: W
authors.lastname: Jerjes
authors.forename: Tahwinder
authors.initials: T
authors.lastname: Upile
authors.forename: Hani
authors.initials: H
authors.lastname: Radhi
authors.forename: Aviva
authors.initials: A
authors.lastname: Petrie
authors.forename: Jesuloba
authors.initials: J
authors.lastname: Abiola
authors.forename: Aidan
authors.initials: A
authors.lastname: Adams
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Callear
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Kafas
authors.forename: Syedda
authors.initials: S
authors.lastname: Abbas
authors.forename: Kartic
authors.initials: K
authors.lastname: Rajaram
authors.forename: Colin
authors.initials: C
authors.lastname: Hopper
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D008198:Lymph Nodes / Q000000981:diagnostic imaging / Q000473:pathology*; D009062:Mouth Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D009367:Neoplasm Staging / Q000379:methods*; D010610:Pharyngeal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D012189:Retrospective Studies; D014463:Ultrasonography