title: Percutaneous ultrasound-guided radiofrequency ablation treatment and genetic testing for renal cell carcinoma with Von Hippel-Lindau disease.
abstract: Percutaneous ultrasound-guided radiofrequency ablation is increasingly being studied in the treatment of renal tumors. Because percutaneous ultrasound-guided radiofrequency ablation is a minimally invasive and nephron-sparing procedure, it is ideally suited for patients with a single kidney, multiple tumors, or contraindications to conventional surgery. We report on a patient with Von Hippel-Lindau (VHL) disease who had multicentric tumors in the single kidney that was successfully treated with percutaneous ultrasound-guided radiofrequncy ablation. The one-year follow-up showed that there was no local recurrence or metastasis. And genetic testing showed the patient had a T to G heterozygotic missense mutation at nucleotide 515 of VHL gene exon 1.
authors.affiliation: Department of Urology, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Gao
authors.forename: Ming
authors.initials: M
authors.lastname: Xu
authors.forename: Zuo-Feng
authors.initials: ZF
authors.lastname: Xu
authors.forename: Da-Wei
authors.initials: DW
authors.lastname: Liu
authors.forename: Xiang-An
authors.initials: XA
authors.lastname: Tu
authors.forename: Yan-Ling
authors.initials: YL
authors.lastname: Zheng
authors.forename: Dao-Hu
authors.initials: DH
authors.lastname: Wang
authors.forename: Xiang-Zhou
authors.initials: XZ
authors.lastname: Sun
authors.forename: Fu-Fu
authors.initials: FF
authors.lastname: Zheng
authors.forename: Shao-Peng
authors.initials: SP
authors.lastname: Qiu
authors.forename: Ming-De
authors.initials: MD
authors.lastname: Lü
authors.forename: Yuan-Yuan
authors.initials: YY
authors.lastname: Zhang
authors.forename: Xiao-Yan
authors.initials: XY
authors.lastname: Xie
authors.forename: Chun-Hua
authors.initials: CH
authors.lastname: Deng
mesh_terms: D055011:Ablation Techniques / Q000379:methods*; D002292:Carcinoma, Renal Cell / Q000150:complications / Q000235:genetics / Q000473:pathology / Q000601:surgery*; D006651:Histocytochemistry; D006801:Humans; D007680:Kidney Neoplasms / Q000150:complications / Q000235:genetics / Q000473:pathology / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D020125:Mutation, Missense; D025321:Surgery, Computer-Assisted / Q000379:methods*; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography / Q000379:methods*; D051794:Von Hippel-Lindau Tumor Suppressor Protein / Q000235:genetics; D006623:von Hippel-Lindau Disease / Q000150:complications / Q000235:genetics*
chemical_list: D051794:Von Hippel-Lindau Tumor Suppressor Protein; C497446:VHL protein, human