title: [Tissue development and construction and its regulational mechanism].
abstract: From the perspective of Regenerative Medicine, the tissue generated in vitro can imitate the physiological and pathological tissue to a certain extent. However, the structures and functions of the in vitro tissue are very simple so that research on in vitro self-assembling and imitating of tissue development is necessary. The development of Nanotechnology and the technology of micro-structure makes the in vitro tissue assembling possible. As previous studies showed that, besides genetic material, tissue architecture and its micro-environment are closely related to morphogenesis of in vitro tissue. Thus, how to design and assemble microstructure to make the tissue molding still requires effort. How to predict and control the development mechanism in vitro is also a question needed to be resolved. In this essay, we reviewed the mechanism of assembling and imitating of in vitro tissue based on the theory of physics, biology and systemic integrated structure.
authors.affiliation: Department of Plastic and Cosmetic Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, China.
authors.forename: Yicheng
authors.initials: Y
authors.lastname: Wang
authors.forename: Yiming
authors.initials: Y
authors.lastname: Zhang
authors.forename: Dongli
authors.initials: D
authors.lastname: Fan
mesh_terms: D000818:Animals; D003198:Computer Simulation; D006801:Humans; D055616:Microtechnology / Q000379:methods; D049329:Nanostructures / Q000737:chemistry; D044968:Regenerative Medicine / Q000379:methods*; D023822:Tissue Engineering / Q000379:methods