title: Histologic remission of cardiac amyloidosis: a case report.
abstract: The main determinant of survival in amyloid light chain amyloidosis is cardiac involvement. The rate of change in wall thickness may be a strong predictor of survival. After treatment, some hematologic responders have had documented regression of wall thickness by echocardiography with resolution of heart failure symptoms. Herein, we demonstrate a case of treated immunoglobulin light chain cardiac amyloidosis with echocardiographic wall thinning and cardiac biopsies demonstrating complete histologic remission. This observation suggests a mechanism of treatment response and that with appropriately timed treatment, cardiac deposition of amyloid fibrils can be completely reversed.
authors.affiliation: Division of Cardiovascular Diseases, Mayo Clinic Scottsdale, Arizona, USA.
authors.forename: Matthew R
authors.initials: MR
authors.lastname: Nelson
authors.forename: Louis A
authors.initials: LA
authors.lastname: Lanza
authors.forename: Craig B
authors.initials: CB
authors.lastname: Reeder
authors.forename: Robert L
authors.initials: RL
authors.lastname: Scott
authors.forename: Ann E
authors.initials: AE
authors.lastname: McCullough
authors.forename: Krishnaswamy
authors.initials: K
authors.lastname: Chandrasekaran
authors.forename: Roger L
authors.initials: RL
authors.lastname: Click
mesh_terms: D000682:Amyloid / Q000378:metabolism; D000686:Amyloidosis / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000378:metabolism; D009202:Cardiomyopathies / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D012074:Remission Induction; D014213:Tretoquinol; D014463:Ultrasonography
chemical_list: D000682:Amyloid; C518669:amyloid L, human; D014213:Tretoquinol