title: A novel process for recovery and refining of L-lactic acid from fermentation broth.
abstract: This paper introduces a novel process for recovery and refining of L-lactic acid from a fermentation broth. The use of a solvent extraction step, in the novel approach, has significant impacts on the following centrifugal short-path distillation conditions (operating pressure, evaporator temperature and feed flow rate). As the conditions were varied, the l-lactic acid purity and yield in the distillate were monitored. For the purpose of comparison, a series of experiments were also carried out using the existing purification process. The results showed that both of the two processes can obtain l-lactic acid with a high purity around 91.3%, while the yield obtained using the novel process reached 61.73%, which was about 20.43% higher than that using the existing process. Additionally, multiple-pass distillation observed special attention by improving the yield up to 74.63%.
authors.affiliation: State Key Laboratory of Chemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China.
authors.forename: Lijun
authors.initials: L
authors.lastname: Chen
authors.forename: Aiwu
authors.initials: A
authors.lastname: Zeng
authors.forename: Haibo
authors.initials: H
authors.lastname: Dong
authors.forename: Qi
authors.initials: Q
authors.lastname: Li
authors.forename: Congcong
authors.initials: C
authors.lastname: Niu
mesh_terms: D001709:Biotechnology / Q000379:methods*; D003470:Culture Media / Q000737:chemistry*; D057168:Distillation; D005285:Fermentation / Q000502:physiology*; D019344:Lactic Acid / Q000302:isolation & purification*; D011312:Pressure; D012212:Rheology; D013696:Temperature; D014835:Volatilization
chemical_list: D003470:Culture Media; D019344:Lactic Acid