title: Pesticide use, immunologic conditions, and risk of non-Hodgkin lymphoma in Canadian men in six provinces.
abstract: Pesticide exposures and immune suppression have been independently associated with the risk of non-Hodgkin lymphoma (NHL), but their joint effect has not been well explored. Data from a case-control study of men from six Canadian provinces were used to evaluate the potential effect modification of asthma, allergies, or asthma and allergies and hay fever combined on NHL risk from use of: (i) any pesticide; (ii) any organochlorine insecticide; (iii) any organophosphate insecticide; (iv) any phenoxy herbicide; (v) selected individual pesticides [1,1'-(2,2,2-trichloroethylidene)bis[4-chlorobenzene]; 1,1,1-trichloro-2,2-bis(4-chlorophenyl) ethane (DDT), malathion, (4-chloro-2-methylphenoxy)acetic acid (MCPA), mecoprop, and (2,4-dichlorophenoxy)acetic acid (2,4-D); and (vi) from the number of potentially carcinogenic pesticides. Incident NHL cases (n = 513) diagnosed between 1991 and 1994 were recruited from provincial cancer registries and hospitalization records and compared to 1,506 controls. A stratified analysis was conducted to calculate odds ratios (ORs) adjusted for age, province, proxy respondent, and diesel oil exposure. Subjects with asthma, allergies, or hay fever had non-significantly elevated risks of NHL associated with use of MCPA (OR = 2.67, 95% confidence interval [CI]: 0.90-7.93) compared to subjects without any of these conditions (OR = 0.81, 95% CI: 0.39-1.70). Conversely, those with asthma, allergies, or hay fever who reported use of malathion had lower risks of NHL (OR = 1.25, 95% CI: 0.69-2.26) versus subjects with none of these conditions (OR = 2.44, 95% CI: 1.65-3.61). Similar effects were observed for asthma and allergies evaluated individually. Although there were some leads regarding effect modification by these immunologic conditions on the association between pesticide use and NHL, small numbers, measurement error and possible recall bias limit interpretation of these results.
authors.affiliation: University of Toronto, Dalla Lana School of Public Health, 155 College Street, Toronto, Ontario, M5T 3M7.
authors.forename: Manisha
authors.initials: M
authors.lastname: Pahwa
authors.forename: Shelley A
authors.initials: SA
authors.lastname: Harris
authors.forename: Karin
authors.initials: K
authors.lastname: Hohenadel
authors.forename: John R
authors.initials: JR
authors.lastname: McLaughlin
authors.forename: John J
authors.initials: JJ
authors.lastname: Spinelli
authors.forename: Punam
authors.initials: P
authors.lastname: Pahwa
authors.forename: James A
authors.initials: JA
authors.lastname: Dosman
authors.forename: Aaron
authors.initials: A
authors.lastname: Blair
mesh_terms: D001249:Asthma / Q000150:complications / Q000276:immunology; D002170:Canada; D016022:Case-Control Studies; D004781:Environmental Exposure / Q000009:adverse effects; D005742:Gasoline / Q000506:poisoning; D006540:Herbicides / Q000506:poisoning; D006801:Humans; D006967:Hypersensitivity / Q000150:complications / Q000276:immunology; D015994:Incidence; D007306:Insecticides / Q000506:poisoning; D008228:Lymphoma, Non-Hodgkin / Q000139:chemically induced* / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects; D016017:Odds Ratio; D010575:Pesticides / Q000506:poisoning*; D006255:Rhinitis, Allergic, Seasonal / Q000150:complications / Q000276:immunology; D018570:Risk Assessment; D012307:Risk Factors
chemical_list: D005742:Gasoline; D006540:Herbicides; D007306:Insecticides; D010575:Pesticides