title: Generalized pustular psoriasis in a child: observation of long-term combination therapy with etretinate and calcipotriol for 16 years.
abstract: Generalized pustular psoriasis (GPP) is a rare condition in young children. It is difficult to treat and may require long-term systemic therapy. We report the long-term course of a 3-year-old boy whose onset of psoriasis dated to age 7 months. He was treated with etretinate and psoralen plus ultraviolet A therapy initially and then with etretinate alone, and at age 12, topical calcipotriol was added. At the age of 19, he had been taking oral retinoids for 16 years, with a mean dose of etretinate of 0.22 mg/kg per day, a total amount of approximately 37 g, without evidence of stunted growth, ligamentous calcification, hyperostosis, or hepatic toxicity.
authors.affiliation: Department of Dermatology, Tokai University School of Medicine, Kanagawa, Japan. yoshinori.umezawa@jikei.ac.jp
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Umezawa
authors.forename: Tomotaka
authors.initials: T
authors.lastname: Mabuch
authors.forename: Akira
authors.initials: A
authors.lastname: Ozawa
mesh_terms: D000293:Adolescent; D002117:Calcitriol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003879:Dermatologic Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005050:Etretinate / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011701:PUVA Therapy; D011565:Psoriasis / Q000188:drug therapy*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D003879:Dermatologic Agents; C055085:calcipotriene; D005050:Etretinate; D002117:Calcitriol