title: Computational simulations of hemodynamic changes within thoracic, coronary, and cerebral arteries following early wall remodeling in response to distal aortic coarctation.
abstract: Mounting evidence suggests that the pulsatile character of blood pressure and flow within large arteries plays a particularly important role as a mechano-biological stimulus for wall growth and remodeling. Nevertheless, understanding better the highly coupled interactions between evolving wall geometry, structure, and properties and the hemodynamics will require significantly more experimental data. Computational fluid-solid-growth models promise to aid in the design and interpretation of such experiments and to identify candidate mechanobiological mechanisms for the observed arterial adaptations. Motivated by recent aortic coarctation models in animals, we used a computational fluid-solid interaction model to study possible local and systemic effects on the hemodynamics within the thoracic aorta and coronary, carotid, and cerebral arteries due to a distal aortic coarctation and subsequent spatial variations in wall adaptation. In particular, we studied an initial stage of acute cardiac compensation (i.e., maintenance of cardiac output) followed by early arterial wall remodeling (i.e., spatially varying wall thickening and stiffening). Results suggested, for example, that while coarctation increased both the mean and pulse pressure in the proximal vessels, the locations nearest to the coarctation experienced the greatest changes in pulse pressure. In addition, after introducing a spatially varying wall adaptation, pressure, left ventricular work, and wave speed all increased. Finally, vessel wall strain similarly experienced spatial variations consistent with the degree of vascular wall adaptation.
authors.affiliation: Department of Bioengineering, Stanford University, Stanford, CA, USA.
authors.forename: Jessica S
authors.initials: JS
authors.lastname: Coogan
authors.forename: Jay D
authors.initials: JD
authors.lastname: Humphrey
authors.forename: C Alberto
authors.initials: CA
authors.lastname: Figueroa
mesh_terms: D000818:Animals; D001017:Aortic Coarctation / Q000503:physiopathology*; D062186:Arterial Pressure; D001783:Blood Flow Velocity; D001794:Blood Pressure; D002302:Cardiac Output; D002536:Cerebral Arteries / Q000503:physiopathology*; D003198:Computer Simulation; D003331:Coronary Vessels / Q000503:physiopathology*; D006801:Humans; D008955:Models, Cardiovascular; D013895:Thoracic Arteries / Q000503:physiopathology*