title: Maternal body mass index is a predictor of neonatal hypoglycemia in gestational diabetes mellitus.
abstract: BACKGROUND
  In diabetic pregnancy, neonatal hypoglycemia (NH) is usually attributed to insufficient regulation of maternal glycemic control. Recent data suggest that maternal body mass index (BMI) could have an influence.
  
  
  OBJECTIVE
  Our objective was to determine whether an association exists between maternal prepregnancy BMI category and occurrence of NH among infants born to women with gestational diabetes mellitus (GDM).
  
  
  METHODS
  This was a retrospective study including all GDM pregnancies delivered between 1986 and 2006 at a tertiary care center (Hospital de la Santa Creu i Sant Pau, Barcelona). PATIENTS AND OUTCOMES: GDM was diagnosed using universal screening and National Diabetes Data Group criteria. Two thousand ninety-two newborns (1925 singletons, 85% of total GDM offspring) were studied. NH was defined according to Cornblath criteria. In addition to maternal BMI, we considered other variables such as glucose values at diagnosis or third-trimester glycated hemoglobin as potential predictors of NH. We explored whether the association between maternal BMI and NH could be due to intermediate steps such as cesarean section or abnormal birth weight.
  
  
  RESULTS
  The rate of NH was 3%. In the bivariate analysis, prepregnancy BMI was higher in the NH group (24.45 vs. 23.19 kg/m(2), P < 0.02). In the logistic regression analysis, prepregnancy BMI of at least 25 kg/m(2) was independently associated with NH whether the analysis included intermediate variables (odds ratio = 2.11; 95% confidence interval = 1.10-4.03) or not (odds ratio = 2.66; 95% confidence interval = 1.44-4.92).
  
  
  CONCLUSIONS
  Pregestational BMI should be considered among the predictors of NH in offspring of women with GDM.
authors.affiliation: Servei d'Endocrinologia i Nutrició, Hospital de la Santa Creu i Sant Pau, Sant Antoni M Claret, 167, Barcelona 08025, Spain. 31178agp@comb.es
authors.forename: Apolonia
authors.initials: A
authors.lastname: García-Patterson
authors.forename: Anna
authors.initials: A
authors.lastname: Aulinas
authors.forename: Miguel Ángel
authors.initials: MÁ
authors.lastname: María
authors.forename: Justa
authors.initials: J
authors.lastname: Ubeda
authors.forename: Inmaculada
authors.initials: I
authors.lastname: Orellana
authors.forename: Gemma
authors.initials: G
authors.lastname: Ginovart
authors.forename: Juan María
authors.initials: JM
authors.lastname: Adelantado
authors.forename: Alberto
authors.initials: A
authors.lastname: de Leiva
authors.forename: Rosa
authors.initials: R
authors.lastname: Corcoy
mesh_terms: D000328:Adult; D015992:Body Mass Index; D016640:Diabetes, Gestational / Q000175:diagnosis / Q000503:physiopathology*; D005260:Female; D006442:Glycated Hemoglobin; D006801:Humans; D007003:Hypoglycemia / Q000151:congenital*; D007231:Infant, Newborn; D011247:Pregnancy; D012189:Retrospective Studies
chemical_list: D006442:Glycated Hemoglobin