title: Histopathology of peripapillary choroidal neovascularization.
abstract: The different therapeutic responses observed among choroidal neovascularization (CNV) of different etiologies, ages, and locations might be related to the presence of varied mediators. Two surgically removed peripapillary CNVs from two different patients were analyzed. One of the patients had received one intravitreous injection of bevacizumab 3 months earlier. CNV was analyzed using conventional histology and immunohistochemistry. Histological analysis showed intense neovascularization and epithelial and glial components. Vascular endothelial growth factor (VEGF) receptors were found in the endothelial cells and the epithelial cells of the CNV. VEGF was expressed in the patient who had not been previously treated with anti-VEGF. The CNV was deeply infiltrated by glial cells and invaded by microglial cells in one case. VEGF and VEGF receptors may be expressed, suggesting that therapies aiming at VEGF may be efficient only for a subtype of CNV and at a certain time point of their evolution.
authors.affiliation: Department of Ophthalmology, Albacete Medical School, Castilla La Mancha University, Albacete, Spain. josemaria.ruiz@uclm.es
authors.forename: Jose Maria
authors.initials: JM
authors.lastname: Ruiz-Moreno
authors.forename: Javier A
authors.initials: JA
authors.lastname: Montero
authors.forename: Laurent
authors.initials: L
authors.lastname: Jonet
authors.forename: Jean-Claude P
authors.initials: JC
authors.lastname: Jeanny
authors.forename: Francine
authors.initials: F
authors.lastname: Behar-Cohen
mesh_terms: D000328:Adult; D000368:Aged; D020256:Choroidal Neovascularization / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D000072483:Placenta Growth Factor; D011257:Pregnancy Proteins / Q000378:metabolism; D040262:Receptors, Vascular Endothelial Growth Factor / Q000378:metabolism; D042442:Vascular Endothelial Growth Factors / Q000378:metabolism
chemical_list: C000608036:PGF protein, human; D011257:Pregnancy Proteins; D042442:Vascular Endothelial Growth Factors; D000072483:Placenta Growth Factor; D040262:Receptors, Vascular Endothelial Growth Factor