title: The expression profile of the tumor suppressor gene Lzts1 suggests a role in neuronal development.
abstract: BACKGROUND
  Neuronal circuit assembly comprises a number of developmental processes that ultimately underlie function. Identifying the molecular events that dictate these processes can give key insights into how neuronal circuit formation is coordinated. To begin to identify such molecular mechanisms, we have analysed the expression of a candidate gene of entirely unknown function within the nervous system. Here we reveal the spatial and temporal distribution of Lzts1 in mouse and chick embryonic spinal cord and propose potential biological functions.
  
  
  RESULTS
  Lzts1 mRNA is transiently expressed at the border of the ventricular and mantle zones in subsets of sensory and motor spinal neurons. The protein is localized to the cell body, axon, and trailing process of motor, commissural, and dorsal root neurons during development.
  
  
  CONCLUSIONS
  Taken together, the spatial and temporal distribution of Lzts1 is consistent with a potential function(s) in cell cycle regulation, axon growth or guidance, and/or migration of neurons.
authors.affiliation: Umeå Center for Molecular Medicine, Umeå University, Umeå, Sweden.
authors.forename: Marlene
authors.initials: M
authors.lastname: Kropp
authors.forename: Sara I
authors.initials: SI
authors.lastname: Wilson
mesh_terms: D000818:Animals; D001369:Axons / Q000378:metabolism; D002642:Chick Embryo; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D016350:Leucine Zippers; D051379:Mice; D055495:Neurogenesis; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D013116:Spinal Cord / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D025521:Tumor Suppressor Proteins / Q000235:genetics* / Q000378:metabolism
chemical_list: D004268:DNA-Binding Proteins; C574993:Lzts1 protein, mouse; D025521:Tumor Suppressor Proteins