title: Association mapping and disease: evolutionary perspectives.
abstract: In this chapter, we give a short introduction to the genetics of complex disease with special emphasis on evolutionary models for disease genes and the effect of different models on the genetic architecture, and finally give a survey of the state-of-the-art of genome-wide association studies.
authors.affiliation: deCODE Genetics, Reykjavik, Iceland.
authors.forename: Søren
authors.initials: S
authors.lastname: Besenbacher
authors.forename: Thomas
authors.initials: T
authors.lastname: Mailund
authors.forename: Mikkel H
authors.initials: MH
authors.lastname: Schierup
mesh_terms: D003627:Data Interpretation, Statistical; D004194:Disease / Q000235:genetics*; D019143:Evolution, Molecular; D005787:Gene Frequency; D055106:Genome-Wide Association Study / Q000379:methods*; D006801:Humans