title: Clinical comparison of plaque inhibition effects of a novel stabilized stannous fluoride dentifrice and a chlorhexidine digluconate dentifrice using digital plaque imaging.
abstract: OBJECTIVE
  To compare the plaque inhibition efficacy of a novel 0.454% stannous fluoride (SnF2) test dentifrice with sodium hexametaphosphate and stannous chloride to a chlorhexidine digluconate (0.05%), aluminium lactate (0.8%), and aluminium fluoride marketed control dentifrice (Lacalut Aktiv or AlF3/Chx).
  
  
  METHODS
  This was a randomized, two-treatment, two-period, double-blind crossover study that compared the SnF2 test dentifrice to the AlF3/Chx control dentifrice. Each of the two treatment periods lasted for 17 consecutive days of product use, during which subjects were required to brush twice per day with their assigned dentifrice using a standard manual toothbrush (Oral-B P35 Indicator). The two periods of the crossover were separated by a four-day washout period. Plaque levels on the facial anterior tooth surfaces were evaluated and averaged among three assessment days at the end of each treatment period using digital plaque imaging analysis (DPIA). The evening prior to assessments, subjects only brushed lingual surfaces. Assessment time points were carried out in the morning following no morning brushing (A.M. pre-brush), following 40 seconds of brushing with the assigned dentifrice (A.M. post-brush), and in the afternoon (P.M.). The DPIA captured images were used to calculate and analyze visible plaque coverage.
  
  
  RESULTS
  Twenty-eight subjects were randomized and completed the study. At each assessment time point, the SnF2 test dentifrice demonstrated a statistically significant lower plaque level compared to the AlF3/Chx dentifrice: A.M. mean pre-brush 15.9% lower, p < 0.05; A.M. mean post-brush 22.2% lower, p < 0.05; P.M. mean 24.3% lower, p < 0.005.
  
  
  CONCLUSIONS
  Compared to the AlF3/Chx control dentifrice, the novel SnF2 test dentifrice significantly inhibited plaque regrowth overnight and during the day. Immediately after brushing there was also significantly less plaque coverage with the SnF2 test dentifrice.
authors.affiliation: Procter & Gamble, London Innovation Centre, Egham, Surrey, UK. bellamy.pg@pg.com
authors.forename: P G
authors.initials: PG
authors.lastname: Bellamy
authors.forename: A
authors.initials: A
authors.lastname: Boulding
authors.forename: S
authors.initials: S
authors.lastname: Farmer
authors.forename: T N
authors.initials: TN
authors.lastname: Day
authors.forename: A J
authors.initials: AJ
authors.lastname: Mussett
authors.forename: M L
authors.initials: ML
authors.lastname: Barker
mesh_terms: D000328:Adult; D017607:Aluminum Compounds / Q000627:therapeutic use; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D002710:Chlorhexidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D018592:Cross-Over Studies; D003773:Dental Plaque / Q000473:pathology / Q000517:prevention & control*; D003802:Dentifrices / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005459:Fluorides / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D007773:Lactates / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010710:Phosphates / Q000627:therapeutic use; D017971:Tin Compounds / Q000627:therapeutic use; D014002:Tin Fluorides / Q000627:therapeutic use*; D014099:Toothbrushing / Q000295:instrumentation / Q000379:methods; D055815:Young Adult
chemical_list: D017607:Aluminum Compounds; D000891:Anti-Infective Agents, Local; D003802:Dentifrices; D007773:Lactates; D010710:Phosphates; D017971:Tin Compounds; D014002:Tin Fluorides; C023599:stannous chloride; C010882:chlorhexidine gluconate; C009285:sodium polymetaphosphate; D005459:Fluorides; D002710:Chlorhexidine; C104223:aluminum lactate; C032311:aluminum fluoride