title: Sweet block copolymer nanoparticles: preparation and self-assembly of fully oligosaccharide-based amphiphile.
abstract: The preparation of biocompatible nanocarriers that have potential applications in the cosmetic and health industries is highly desired. The self-assembly of amphiphilic block copolymers displaying biosourced polysaccharides at the surface is one of the most promising approaches. In the continuity of our works related to the preparation of "hybrid" amphiphilic oligosaccharide-based block copolymers, we present here the design of a new generation of self-assembled nanoparticles composed entirely of oligosaccharide-based amphiphilic block co-oligomers (BCO). These systems are defined by a covalent linkage of the two saccharidic blocks through their reducing end units, resulting in a sweet "head-to-head" connection. As an example, we have prepared and studied a BCO in which the hydrophilic part is composed of a free maltoheptaosyl derivative clicked to a hydrophobic part composed of a peracetylated maltoheptaosyl derivative. This amphiphilic BCO self-assembles to form spherical micelles in water with an average diameter of 30 nm. The efficient enzymatic hydrolysis of the maltoheptaose that constitutes the shell of the micelles was followed by light scattering and colorimetric methods.
authors.affiliation: Centre de Recherches sur les Macromolécules Végétales, CERMAV-CNRS (Affiliated with Université Joseph Fourier, and member of the Institut de Chimie Moléculaire de Grenoble), Grenoble, France.
authors.forename: Samuel
authors.initials: S
authors.lastname: de Medeiros Modolon
authors.forename: Issei
authors.initials: I
authors.lastname: Otsuka
authors.forename: Sébastien
authors.initials: S
authors.lastname: Fort
authors.forename: Edson
authors.initials: E
authors.lastname: Minatti
authors.forename: Redouane
authors.initials: R
authors.lastname: Borsali
authors.forename: Sami
authors.initials: S
authors.lastname: Halila
mesh_terms: D001234:Aspergillus niger / Q000201:enzymology; D001704:Biopolymers / Q000737:chemistry* / Q000378:metabolism; D002236:Carbohydrate Conformation; D005087:Glucan 1,4-alpha-Glucosidase / Q000737:chemistry / Q000378:metabolism; D005936:Glucans / Q000737:chemistry / Q000378:metabolism; D006868:Hydrolysis; D057927:Hydrophobic and Hydrophilic Interactions; D008823:Micelles; D053758:Nanoparticles / Q000737:chemistry*; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D010316:Particle Size; D013499:Surface Properties; D013501:Surface-Active Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism
chemical_list: D001704:Biopolymers; D005936:Glucans; D008823:Micelles; D009844:Oligosaccharides; D013501:Surface-Active Agents; C031146:maltoheptaose; D005087:Glucan 1,4-alpha-Glucosidase