title: In vivo evidence that the increase in matrix metalloproteinase activity occurs early after cerebral ischemia.
abstract: There is controversy over whether matrix metalloproteinases (MMPs) are activated during the early therapeutic window following ischemic stroke. Ex vivo, an increase was reported as early as 4 hours, whereas in vivo, no increase was found until 24 hours postischemia. We used fluorescence diffuse optical tomography to image MMP activity following experimental cerebral ischemia; increased MMP activity was observed in the ischemic area as early as 3 to 6 hours after ischemic onset and correlated with the volume of ischemic cerebral tissue. Therefore, MMP activation is an immediate early response to cerebral ischemia concurrent with the therapeutic window.
authors.affiliation: INSERM U1023, Université Paris Sud, France. amartin@cicbiomagune.es
authors.forename: Abraham
authors.initials: A
authors.lastname: Martín
authors.forename: Anikitos
authors.initials: A
authors.lastname: Garofalakis
authors.forename: Bertrand
authors.initials: B
authors.lastname: Tavitian
mesh_terms: D000818:Animals; D001921:Brain / Q000201:enzymology / Q000473:pathology; D002545:Brain Ischemia / Q000201:enzymology* / Q000473:pathology; D008297:Male; D020782:Matrix Metalloproteinases / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D014057:Tomography, X-Ray Computed
chemical_list: D020782:Matrix Metalloproteinases