title: Homeward bound: how do skin dendritic cells find their way into the lymph system?
abstract: The success of the adaptive immune system relies upon the transport of antigens by dendritic cells (DCs) from skin via lymphatic vessels to lymph nodes where DCs present antigen to T cells. Little is known about the requirements for so-called "reverse transmigration" (RT). Torzicky et al. in this issue demonstrate that CD31, CD99, and CXCR4 play key roles in RT, suggesting that adhesion occurs in a defined sequence during the passage of DC into lymphatics.
authors.affiliation: Department of Dermatology, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA. sthwang@mcw.edu
authors.forename: Sam T
authors.initials: ST
authors.lastname: Hwang
mesh_terms: D000071443:12E7 Antigen; D015703:Antigens, CD / Q000502:physiology*; D015815:Cell Adhesion Molecules / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology*; D003713:Dendritic Cells / Q000473:pathology*; D006801:Humans; D008208:Lymphatic System / Q000502:physiology*; D008297:Male; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000502:physiology*; D057705:Transendothelial and Transepithelial Migration / Q000502:physiology*
chemical_list: D000071443:12E7 Antigen; D015703:Antigens, CD; C061828:CD99 protein, human; D015815:Cell Adhesion Molecules; D019408:Platelet Endothelial Cell Adhesion Molecule-1