title: Influence of post-treatment with 75% (v/v) ethanol vapor on the properties of SF/P(LLA-CL) nanofibrous scaffolds.
abstract: In order to improve the water-resistant ability of silk fibroin (SF) and SF/P(LLA-CL) blended nanofibrous scaffolds for tissue engineering applications, 75% (v/v) ethanol vapor was used to post-treat electrospun nanofibers. SEM indicated that the treated SF and SF/P(LLA-CL) nanofibrous scaffolds maintained a nanofibrous structure and possessed good water-resistant ability. Characterization of (13)C CP-MAS NMR clarified that 75% (v/v) ethanol vapor could induce SF conformation from random coil or α-helix to β-sheet. Although the water contact showed that treated SF/P(LLA-CL) blended nanofibrous scaffolds were hydrophobic, the water uptake demonstrated that their hydrophilicity was greatly superior to those of pure P(LLA-CL) nanofibrous scaffolds. Furthermore, the treated SF/P(LLA-CL) nanofibrous scaffolds, both in dry state and wet state, could retain good mechanical properties. Therefore, 75% (v/v) ethanol vapor treatment might be an ideal method to treat SF and SF/P(LLA-CL) nanofibrous scaffolds for biomedical applications.
authors.affiliation: College of Materials and Textile Engineering, Jiaxing University, Zhejiang 314001, China.
authors.forename: Kui-Hua
authors.initials: KH
authors.lastname: Zhang
authors.affiliation: College of Materials and Textile Engineering, Jiaxing University, Zhejiang 314001, China.
authors.forename: Qing
authors.initials: Q
authors.lastname: Ye
authors.affiliation: College of Materials and Textile Engineering, Jiaxing University, Zhejiang 314001, China.
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Yan
mesh_terms: D018929:Cell Culture Techniques / Q000295:instrumentation; D000431:Ethanol / Q000737:chemistry / Q000494:pharmacology*; D005349:Fibroins / Q000737:chemistry / Q000187:drug effects*; D057927:Hydrophobic and Hydrophilic Interactions / Q000187:drug effects; D057139:Nanofibers / Q000737:chemistry; D011091:Polyesters / Q000737:chemistry*; D047011:Silk / Q000737:chemistry / Q000187:drug effects; D013499:Surface Properties / Q000187:drug effects; D013718:Tensile Strength / Q000187:drug effects; D023822:Tissue Engineering; D054457:Tissue Scaffolds / Q000737:chemistry*; D014835:Volatilization; D017155:Wettability / Q000187:drug effects
chemical_list: D011091:Polyesters; D047011:Silk; C550605:poly(lactic acid-co-epsilon-caprolactone); D000431:Ethanol; D005349:Fibroins