title: Taste neophobia and c-Fos expression in the rat brain.
abstract: Taste neophobia refers to a reduction in consumption of a novel taste relative to when it is familiar. To gain more understanding of the neural basis of this phenomenon, the current study examined whether a novel taste (0.5% saccharin) supports a different pattern of c-Fos expression than the same taste when it is familiar. Results revealed that the taste of the novel saccharin solution evoked more Fos immunoreactivity than the familiar taste of saccharin in the basolateral region of the amygdala, central nucleus of the amygdala, gustatory portion of the thalamus, and the gustatory insular cortex. No such differential expression was found in the other examined areas, including the bed nucleus of stria terminalis,medial amygdala, and medial parabrachial nucleus. The present results are discussed with respect to a forebrain taste neophobia system.
authors.affiliation: Department of Psychology, University of Illinois at Chicago, 1007 West Harrison Street, Chicago, IL 60607, USA. jlin2@uic.edu
authors.forename: Jian-You
authors.initials: JY
authors.lastname: Lin
authors.forename: Chris
authors.initials: C
authors.lastname: Roman
authors.forename: Joe
authors.initials: J
authors.lastname: Arthurs
authors.forename: Steve
authors.initials: S
authors.lastname: Reilly
mesh_terms: D000818:Animals; D001923:Brain Chemistry / Q000235:genetics* / Q000502:physiology*; D003213:Conditioning, Psychological; D004326:Drinking; D005239:Fear / Q000502:physiology*; D016762:Genes, fos / Q000235:genetics / Q000502:physiology*; D007150:Immunohistochemistry; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012439:Saccharin; D013649:Taste / Q000235:genetics* / Q000502:physiology*
chemical_list: D012439:Saccharin