title: Piecewise exponential survival times and analysis of case-cohort data.
abstract: Case-cohort designs select a random sample of a cohort to be used as control with cases arising from the follow-up of the cohort. Analyses of case-cohort studies with time-varying exposures that use Cox partial likelihood methods can be computer intensive. We propose a piecewise-exponential approach where Poisson regression model parameters are estimated from a pseudolikelihood and the corresponding variances are derived by applying Taylor linearization methods that are used in survey research. The proposed approach is evaluated using Monte Carlo simulations. An illustration is provided using data from the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study of male smokers in Finland, where a case-cohort study of serum glucose level and pancreatic cancer was analyzed.
authors.affiliation: Department of Mathematics, University of Texas at Arlington, Arlington, TX 76019-0408, USA. lisherry@mail.nih.gov
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Mitchell H
authors.initials: MH
authors.lastname: Gail
authors.forename: Dale L
authors.initials: DL
authors.lastname: Preston
authors.forename: Barry I
authors.initials: BI
authors.lastname: Graubard
authors.forename: Jay H
authors.initials: JH
authors.lastname: Lubin
mesh_terms: D000704:Analysis of Variance; D001786:Blood Glucose / Q000032:analysis; D015331:Cohort Studies; D003198:Computer Simulation / Q000706:statistics & numerical data; D019587:Dietary Supplements; D005387:Finland / Q000453:epidemiology; D006306:Health Surveys / Q000706:statistics & numerical data; D006801:Humans; D015994:Incidence; D008175:Lung Neoplasms / Q000453:epidemiology / Q000517:prevention & control; D008297:Male; D009010:Monte Carlo Method; D010190:Pancreatic Neoplasms / Q000097:blood / Q000453:epidemiology; D012044:Regression Analysis; D012907:Smoking / Q000453:epidemiology; D016019:Survival Analysis; D024502:alpha-Tocopherol / Q000008:administration & dosage; D019207:beta Carotene / Q000008:administration & dosage
chemical_list: D001786:Blood Glucose; D019207:beta Carotene; D024502:alpha-Tocopherol