title: Successful use of cyclophosphamide, bortezomib, and dexamethasone to treat a case of relapsed POEMS.
abstract: POEMS syndrome is a rare paraneoplastic condition related to myeloma. Because it is rare, there is very little known about treatment options. The use of potentially neurotoxic chemotherapeutic drugs is of concern in a disease whose major manifestation is neuropathy. Herein, we describe an extraordinary response to the combination of cyclophosphamide, bortezomib, and dexamethasone (CyBorD) in a patient with relapsed, life-threatening POEMS syndrome.
authors.affiliation: Division of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: Rahma
authors.initials: R
authors.lastname: Warsame
authors.forename: Ingrid E
authors.initials: IE
authors.lastname: Kohut
authors.forename: Angela
authors.initials: A
authors.lastname: Dispenzieri
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D001897:Boronic Acids / Q000008:administration & dosage; D000069286:Bortezomib; D003520:Cyclophosphamide / Q000008:administration & dosage; D003907:Dexamethasone / Q000008:administration & dosage; D006801:Humans; D008297:Male; D016878:POEMS Syndrome / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D010257:Paraneoplastic Syndromes / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D011719:Pyrazines / Q000008:administration & dosage; D012008:Recurrence
chemical_list: D001897:Boronic Acids; D011719:Pyrazines; D000069286:Bortezomib; D003907:Dexamethasone; D003520:Cyclophosphamide