title: Effector-triggered immunity signaling: from gene-for-gene pathways to protein-protein interaction networks.
abstract: In its simplicity and testability, Flor's gene-for-gene hypothesis has been a powerful driver in plant immunity research for decades. Once the molecular underpinnings of gene-for-gene resistance had come into sharper focus, there was a reassessment of Flor's hypothesis and a name change to effector-triggered immunity. As implied by the name change and exemplified by pioneering studies, plant immunity is increasingly described in terms of protein rather than genetic interactions. This progress leads to a reinterpretation of old concepts of pathogen recognition and resistance signaling and, of course, opens up new questions. Here, we provide a brief historical overview of resistance gene function and how a new focus on protein interactions can lead to a deeper understanding of the logic of plant innate immunity signaling.
authors.affiliation: Christopher S. Bond Life Sciences Center and Interdisciplinary Plant Group, University of Missouri, Columbia, MO 65211, USA. gassmannw@missouri.edu
authors.forename: Walter
authors.initials: W
authors.lastname: Gassmann
authors.forename: Saikat
authors.initials: S
authors.lastname: Bhattacharjee
mesh_terms: D017343:Genes, Plant / Q000235:genetics / Q000276:immunology; D008957:Models, Genetic; D057865:Plant Immunity / Q000235:genetics / Q000276:immunology*; D010940:Plant Proteins / Q000235:genetics / Q000276:immunology; D010944:Plants / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D060066:Protein Interaction Maps / Q000235:genetics / Q000276:immunology*; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology*
chemical_list: D010940:Plant Proteins