title: Nonionic surfactant and interfacial structure impact crystallinity and stability of β-carotene loaded lipid nanodispersions.
abstract: The stability, crystallization, and melting behavior of canola stearin (CaSt) solid lipid nanoparticle dispersions (SLN) and canola oil-in-water emulsions (COE) with 10 wt % Poloxamer 188 (P188) or Tween 20 (T20) with and without 0.1 wt % β-carotene (BC) were investigated. Particles or droplets with diameters in the range of 115 nm were formed and stable for up to 90 days at 4 or 20 °C. Polymorphism was affected by surfactant type; that is, only β versus both β' and β were observed for the P188 and T20 SLN, respectively. According to Cryo-TEM, the emulsions and SLN were spherical versus platelet-like structures, respectively, with differences observed between SLN with P188 or T20. More surfactant was interfacially adsorbed in the SLN versus COE. Incorporation of BC at 0.1 wt % had no impact on SLN or COE size, polymorphism, or melting behavior. Less BC degradation was observed for the SLN versus COE and during storage at 4 versus 20 °C (p < 0.05).
authors.affiliation: Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, Ontario, Canada.
authors.forename: Amir Malaki
authors.initials: AM
authors.lastname: Nik
authors.forename: Sarah
authors.initials: S
authors.lastname: Langmaid
authors.forename: Amanda J
authors.initials: AJ
authors.lastname: Wright
mesh_terms: D000327:Adsorption; D003460:Crystallization; D004337:Drug Carriers / Q000737:chemistry*; D004355:Drug Stability; D053758:Nanoparticles / Q000737:chemistry*; D013501:Surface-Active Agents / Q000737:chemistry*; D014280:Triglycerides / Q000737:chemistry*; D019207:beta Carotene / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D013501:Surface-Active Agents; D014280:Triglycerides; D019207:beta Carotene; C022618:tristearin