title: Proteus syndrome: three case reports with a review of the literature.
abstract: Proteus syndrome (PS) is a rare, progressive disorder that manifests as asymmetric, disproportionate overgrowth affecting tissues derived from any germline layer. Cases of PS from 2005-2010 were retrieved from the pathology files at our institution. Two confirmed cases and one possible case of PS were identified. All patients came from different ethnic backgrounds. Patient 1 displayed classic skin and overgrowth lesions. Patient 2 displayed various features, particularly vascular malformations. Patient 3 demonstrated a cerebriform connective tissue nevus alone. These patients demonstrate the spectrum of presentations of PS. Much is left to learn about this disfiguring disease.
authors.affiliation: Department of Pediatrics and Pathology, Emory University School ofMedicine, 1405 Clifton Road NE, Atlanta, GA 30322, USA.
authors.forename: Jenna L
authors.initials: JL
authors.lastname: Thomason
authors.forename: C R
authors.initials: CR
authors.lastname: Abramowsky
authors.forename: Richard R
authors.initials: RR
authors.lastname: Rickets
authors.forename: John H
authors.initials: JH
authors.lastname: Culbertson
authors.forename: Matthew S
authors.initials: MS
authors.lastname: Clifton
authors.forename: Bahig M
authors.initials: BM
authors.lastname: Shehata
mesh_terms: D002675:Child, Preschool; D004200:Diseases in Twins / Q000473:pathology; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D016715:Proteus Syndrome / Q000473:pathology*; D014429:Twins, Dizygotic