title: Castleman's disease and arterial thrombosis: result of excessively elevated interleukin-6 plasma level?
abstract: Morbus Castleman is a benign non-clonal lymphoproliverative disorder. Immunomodulatory and antiproliferative drugs are used to treat this plasma cell disorder. We report the case of a 46-year old female patient with multicentric Castleman's disease and limb ischemia. Thrombotic occlusions of the popliteal and tibioperoneal arteries were treated by percutaneous thrombus aspiration. We discuss the role of increased interleukin-6 plasma levels during therapy with Tocilizumab, an antibody to interleukin-6 receptor, as a potential cause for arterial thrombosis.
authors.affiliation: Clinic for Angiology, University Hopsital Zurich, Switzerland. anette.schumacher@usz.ch
authors.forename: Anette
authors.initials: A
authors.lastname: Schumacher
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Jacomella
authors.forename: Georg
authors.initials: G
authors.lastname: Stüssi
authors.forename: Beatrice
authors.initials: B
authors.lastname: Amann-Vesti
authors.forename: Natascia
authors.initials: N
authors.lastname: Corti
authors.forename: Marc
authors.initials: M
authors.lastname: Husmann
mesh_terms: D061067:Antibodies, Monoclonal, Humanized / Q000009:adverse effects*; D001157:Arterial Occlusive Diseases / Q000097:blood / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000276:immunology / Q000628:therapy; D005871:Castleman Disease / Q000097:blood / Q000188:drug therapy* / Q000276:immunology; D003251:Constriction, Pathologic; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000009:adverse effects*; D015850:Interleukin-6 / Q000097:blood*; D008875:Middle Aged; D011150:Popliteal Artery / Q000000981:diagnostic imaging; D013256:Steroids / Q000009:adverse effects; D013927:Thrombosis / Q000097:blood / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000276:immunology / Q000628:therapy; D016909:Tibial Arteries / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D015854:Up-Regulation
chemical_list: D061067:Antibodies, Monoclonal, Humanized; C508600:IL6 protein, human; D007155:Immunologic Factors; D015850:Interleukin-6; D013256:Steroids; C502936:tocilizumab