title: The uncommon combination of common variable immunodeficiency, macrophage activation syndrome, and cytomegalovirus retinitis.
abstract: Common variable immunodeficiency (CVID) is a heterogeneous group of disorders with varied immunologic phenotypes and clinical manifestations. Patients with CVID are mainly characterized by decreased serum immunoglobulin levels, and increased susceptibility to recurrent bacterial infections, autoimmune disorders, and malignancies. Here we present a CVID patient who has developed a clinical polyclonal lymphocytic infiltration phenotype associated with severe and irreversible pancytopenia with unknown etiology. Progressive unilateral loss of vision and cytomegalovirus retinitis indicated the cause of patient's pancytopenia.
authors.affiliation: Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran. aghamohammadi@sina.tums.ac.ir
authors.forename: Asghar
authors.initials: A
authors.lastname: Aghamohammadi
authors.forename: Hassan
authors.initials: H
authors.lastname: Abolhassani
authors.forename: Armin
authors.initials: A
authors.lastname: Hirbod-Mobarakeh
authors.forename: Fariba
authors.initials: F
authors.lastname: Ghassemi
authors.forename: Shervin
authors.initials: S
authors.lastname: Shahinpour
authors.forename: Nasrin
authors.initials: N
authors.lastname: Behniafard
authors.forename: Ghazal
authors.initials: G
authors.lastname: Naghibzadeh
authors.forename: Amir
authors.initials: A
authors.lastname: Imanzadeh
authors.forename: Nima
authors.initials: N
authors.lastname: Rezaei
mesh_terms: D002648:Child; D002675:Child, Preschool; D017074:Common Variable Immunodeficiency / Q000150:complications* / Q000276:immunology / Q000473:pathology; D017726:Cytomegalovirus Retinitis / Q000150:complications* / Q000276:immunology / Q000473:pathology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D055501:Macrophage Activation Syndrome / Q000150:complications* / Q000276:immunology / Q000473:pathology; D008297:Male