title: Related factors of insulin resistance in Korean children: adiposity and maternal insulin resistance.
abstract: Increased adiposity and unhealthy lifestyle augment the risk for type 2 diabetes in children with familial predisposition. Insulin resistance (IR) is an excellent clinical marker for identifying children at high risk for type 2 diabetes. This study was conducted to investigate parental, physiological, behavioral and socio-economic factors related to IR in Korean children. This study is a cross-sectional study using data from 111 children aged 7 years and their parents. Homeostasis model assessment of insulin resistance (HOMA-IR) was calculated using fasting glucose and insulin level as a marker of IR. All children's adiposity indices (r = 0.309-0.318, all P-value = 0.001) and maternal levels of fasting insulin (r = 0.285, P-value = 0.003) and HOMA-IR (r = 0.290, P-value = 0.002) were positively correlated with children's HOMA-IR level. There was no statistical difference of children's HOMA-IR level according to children's lifestyle habits and socioeconomic status of families. An increase of 1 percentage point in body fat was related to 2.7% increase in children's HOMA-IR (P-value < 0.001) and an increase of 1% of maternal level of HOMA-IR was related to 0.2% increase in children's HOMA-IR (P-value = 0.002). This study shows that children's adiposity and maternal IR are positively associated with children's IR.
authors.affiliation: Department of Family Medicine, Seoul-Paik Hospital, College of Medicine, Inje University, 85 Jeo-dong 2-ga, Jung-gu, Seoul 100032, Korea. jacobel@hanmail.net
authors.forename: Young-Gyu
authors.initials: YG
authors.lastname: Cho
authors.forename: Jae-Heon
authors.initials: JH
authors.lastname: Kang
authors.forename: Yang-Im
authors.initials: YI
authors.lastname: Hur
authors.forename: Jihyun
authors.initials: J
authors.lastname: Song
authors.forename: Kang-Sook
authors.initials: KS
authors.lastname: Lee
mesh_terms: D050154:Adiposity; D002648:Child; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors; D012959:Socioeconomic Factors