title: CPPsite: a curated database of cell penetrating peptides.
abstract: Delivering drug molecules into the cell is one of the major challenges in the process of drug development. In past, cell penetrating peptides have been successfully used for delivering a wide variety of therapeutic molecules into various types of cells for the treatment of multiple diseases. These peptides have unique ability to gain access to the interior of almost any type of cell. Due to the huge therapeutic applications of CPPs, we have built a comprehensive database 'CPPsite', of cell penetrating peptides, where information is compiled from the literature and patents. CPPsite is a manually curated database of experimentally validated 843 CPPs. Each entry provides information of a peptide that includes ID, PubMed ID, peptide name, peptide sequence, chirality, origin, nature of peptide, sub-cellular localization, uptake efficiency, uptake mechanism, hydrophobicity, amino acid frequency and composition, etc. A wide range of user-friendly tools have been incorporated in this database like searching, browsing, analyzing, mapping tools. In addition, we have derived various types of information from these peptide sequences that include secondary/tertiary structure, amino acid composition and physicochemical properties of peptides. This database will be very useful for developing models for predicting effective cell penetrating peptides. Database URL: http://crdd.osdd.net/raghava/cppsite/.
authors.affiliation: Bioinformatics Centre, Institute of Microbial Technology (CSIR), Sector 39-A, Chandigarh, India.
authors.forename: Ankur
authors.initials: A
authors.lastname: Gautam
authors.forename: Harinder
authors.initials: H
authors.lastname: Singh
authors.forename: Atul
authors.initials: A
authors.lastname: Tyagi
authors.forename: Kumardeep
authors.initials: K
authors.lastname: Chaudhary
authors.forename: Rahul
authors.initials: R
authors.lastname: Kumar
authors.forename: Pallavi
authors.initials: P
authors.lastname: Kapoor
authors.forename: G P S
authors.initials: GP
authors.lastname: Raghava
mesh_terms: D057846:Cell-Penetrating Peptides; D003628:Database Management Systems; D030562:Databases, Protein; D020407:Internet; D014584:User-Computer Interface
chemical_list: D057846:Cell-Penetrating Peptides