title: Penile methadone injection in suicidal intent: life-threatening and fatal for erectile function.
abstract: We present the case of a 31-year-old man who was admitted to our emergency  department after injection of 10 mL of methadone into his penis. He had a  history of drug abuse over the last 15 years and a background of 3 attempted  suicidal episodes with a combination of at least 2 drugs over the past 12  months. The current suicide attempt had serious consequences: he suffered from  acute renal and liver failure. One previously unreported side effect of  methadone is erectile dysfunction following injection into the penis. In our  case, the patient received vardenafil 10 mg once daily without any signs of  functional improvement. Ten months after the event, there still was complete  erectile dysfunction.
authors.affiliation: Department of Urology, Academic Hospital Braunschweig, Neustadtring 40, 38114 Braunschweig, Germany. drlucasgp@yahoo.com
authors.forename: Lucas G
authors.initials: LG
authors.lastname: Prado
authors.forename: Johannes
authors.initials: J
authors.lastname: Huber
authors.forename: Christian G
authors.initials: CG
authors.lastname: Huber
authors.forename: Carolin
authors.initials: C
authors.lastname: Mogler
authors.forename: Julia
authors.initials: J
authors.lastname: Ehrenheim
authors.forename: Joanne
authors.initials: J
authors.lastname: Nyarangi-Dix
authors.forename: Sascha
authors.initials: S
authors.lastname: Pahernik
authors.forename: Markus
authors.initials: M
authors.lastname: Hohenfellner
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced; D000328:Adult; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000506:poisoning*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D055030:Drug Users / Q000523:psychology*; D007172:Erectile Dysfunction / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage; D007267:Injections; D017114:Liver Failure, Acute / Q000139:chemically induced; D008297:Male; D008691:Methadone / Q000008:administration & dosage / Q000506:poisoning*; D058850:Opiate Substitution Treatment; D010410:Penile Erection / Q000187:drug effects*; D010413:Penis / Q000187:drug effects* / Q000503:physiopathology; D058986:Phosphodiesterase 5 Inhibitors / Q000008:administration & dosage; D010879:Piperazines / Q000008:administration & dosage; D015819:Substance Abuse, Intravenous / Q000523:psychology / Q000534:rehabilitation*; D013406:Suicide, Attempted; D013450:Sulfones / Q000008:administration & dosage; D014227:Triazines / Q000008:administration & dosage; D000069058:Vardenafil Dihydrochloride
chemical_list: D000701:Analgesics, Opioid; D007093:Imidazoles; D058986:Phosphodiesterase 5 Inhibitors; D010879:Piperazines; D013450:Sulfones; D014227:Triazines; D000069058:Vardenafil Dihydrochloride; D008691:Methadone