title: Suspected opioid overdose case resolved by CYP2D6 genotyping.
abstract: A 14-year-old female with suspected narcotic overdose had CYP2D6 genotyping performed to verify opiate intoxication. The role of pharmacogenetics in pain management and individualization of opiate pharmacotherapy is discussed.
authors.affiliation: Division of Translational Therapeutics, Department of Paediatrics, Faculty of Medicine, University of British Columbia, Canada.
authors.forename: Kaitlyn D
authors.initials: KD
authors.lastname: Shaw
authors.forename: Ursula
authors.initials: U
authors.lastname: Amstutz
authors.forename: Ricardo
authors.initials: R
authors.lastname: Jimenez-Mendez
authors.forename: Colin J D
authors.initials: CJ
authors.lastname: Ross
authors.forename: Bruce C
authors.initials: BC
authors.lastname: Carleton
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage; D000293:Adolescent; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000009:adverse effects* / Q000378:metabolism; D002110:Caffeine / Q000008:administration & dosage; D003061:Codeine / Q000008:administration & dosage / Q000009:adverse effects* / Q000378:metabolism; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics*; D004338:Drug Combinations; D062787:Drug Overdose; D005260:Female; D005838:Genotype; D006801:Humans; D010146:Pain / Q000188:drug therapy; D010597:Pharmacogenetics
chemical_list: D000701:Analgesics, Opioid; D004338:Drug Combinations; D000082:Acetaminophen; D002110:Caffeine; D019389:Cytochrome P-450 CYP2D6; D003061:Codeine