title: Oxidative stress in patients with primary insomnia.
abstract: OBJECTIVE
  Many physiological and pathological processes, such as infections, environmental toxins, and ionizing radiation increase bodily concentrations of oxidizing substances, known as free radicals, which lead to neurodegenerative disorders. Sleep is one of the most important factors contributing to health; however, insomnia is among the most prevalent health complaints.
  
  
  METHODS
  In this study, for the first time in the literature, we investigated the effects of primary insomnia on certain oxidative stress biomarkers. For this purpose, glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and myeloperoxidase (MPO) activities and levels of reduced glutathione (GSH) and malondialdehyde (MDA) were measured in 30 patients with primary insomnia and 30 healthy volunteers
  
  
  RESULTS
  Our results show that the patients with primary insomnia had significantly lower GSH-Px activity and higher MDA levels compared with the controls.
  
  
  CONCLUSIONS
  These results may indicate the important role of sleep in attenuating oxidative stress.
authors.affiliation: Department of Psychiatry, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Gulec
authors.forename: Halil
authors.initials: H
authors.lastname: Ozkol
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Selvi
authors.forename: Yasin
authors.initials: Y
authors.lastname: Tuluce
authors.forename: Adem
authors.initials: A
authors.lastname: Aydin
authors.forename: Lutfullah
authors.initials: L
authors.lastname: Besiroglu
authors.forename: Pınar Guzel
authors.initials: PG
authors.lastname: Ozdemir
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D002374:Catalase / Q000378:metabolism; D005260:Female; D005978:Glutathione / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000378:metabolism*; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism*; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D009195:Peroxidase / Q000378:metabolism*; D007319:Sleep Initiation and Maintenance Disorders / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D008315:Malondialdehyde; D002374:Catalase; D009195:Peroxidase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione