title: Does vitamin B alter the efficacy of botulinum toxin?
abstract: Botulinum toxin prevents acetylcholine release at motor nerve terminals. Group B vitamins (B-vit) are essential for proper nerve function. The present study addresses the question of whether B-vit accelerate recovery in rat skeletal muscle after botulinum toxin A (Btx-A) injection. Forty-four adult male Wistar albino rats were used in this experimental study. Rats were divided into three groups: group 1 rats were given Btx-A injection only, group 2 rats were given B-vit supplementation before Btx-A injection, and group 3 rats were given Btx-A and B-vit injections together. During the experiment, compound muscle action potential (CMAP) of the gastrocnemius muscle was recorded before Btx-A injection and sequentially ten times after toxin injection. The statistical significance of the CMAP amplitude change among the groups was analyzed. All groups showed similar amplitude change between consecutive measurement points. In conclusion, combining Btx-A injection with B-vit supplement does not decrease the efficacy of the toxin.
authors.affiliation: Department of Plastic Reconstructive and Aesthetic Surgery, Sisli Etfal Training and Research Hospital, and Department of Neurology, Istanbul Medical Faculty, İstanbul, Turkey. sonertat@yahoo.com
authors.forename: Soner
authors.initials: S
authors.lastname: Tatlidede
authors.forename: M Baris
authors.initials: MB
authors.lastname: Baslo
authors.forename: Özay
authors.initials: Ö
authors.lastname: Özkaya
authors.forename: Tufan
authors.initials: T
authors.lastname: Soydan
authors.forename: Elif Kocasoy
authors.initials: EK
authors.lastname: Orhan
authors.forename: Ayşin Karasoy
authors.initials: AK
authors.lastname: Yeşilada
mesh_terms: D000200:Action Potentials; D000818:Animals; D019274:Botulinum Toxins, Type A / Q000494:pharmacology*; D004347:Drug Interactions; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000502:physiology*; D009465:Neuromuscular Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014803:Vitamin B Complex / Q000494:pharmacology*
chemical_list: D009465:Neuromuscular Agents; D014803:Vitamin B Complex; D019274:Botulinum Toxins, Type A