title: [Efficacy of hypobaric hypoxia in the treatment of arterial hypertension in postmenopausal women].
abstract: OBJECTIVE
  To assess efficacy of adaptation to periodic hypobaric hypoxia (PHH) in the treatment of postmenopausal women with arterial hypertension (AH).
  
  
  METHODS
  The method of adaptation to PHH in the pressure chamber Ural-1 (22 three-hour daily sessions, pressure 460 mmHg) was used in 46 postmenopausal AH women (mean age 53.8 +/- 3.9 years). The method was assessed for effects on blood pressure (BP), symptoms of menopausal syndrome, body mass, levels of some hormones, lipid and carbohydrate metabolism.
  
  
  RESULTS
  Adaptation to PHH reduced systolic pressure by 13.9%, diastolic one--by 8.2%, the levels of follicule stimulating and luteinising hormones by 26.8 and 21.5%, respectively, cholesterol--by 14.7, glucose--by 21.3, insulin--20.2%; estradiol and dehydroepiandrosteron sulphate concentrations rose by 19.3 and 15.2%, respectively.
  
  
  CONCLUSIONS
  Adaptation to PHH produced an antihypertensive effect and a positive trend in clinicometabolic indices in AH women in postmenopause.
authors.forename: A N
authors.initials: AN
authors.lastname: Tin'kov
authors.forename: O D
authors.initials: OD
authors.lastname: Konstantinova
authors.forename: S K
authors.initials: SK
authors.lastname: Kshniaseva
mesh_terms: D000222:Adaptation, Physiological; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001274:Atmospheric Pressure; D002784:Cholesterol / Q000097:blood; D003131:Combined Modality Therapy; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy / Q000628:therapy*; D000860:Hypoxia / Q000503:physiopathology*; D007986:Luteinizing Hormone / Q000097:blood; D008875:Middle Aged; D017698:Postmenopause / Q000097:blood; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D002784:Cholesterol