title: The growth hormone-prolactin relationship: a neglected issue.
abstract: During embryogenesis, the growth hormone-secreting cells (somatotrophs) and the prolactin-secreting cells (lactotrophs) develop from a common progenitor cell (somatomammotroph). Postnatally, in situations when one of these two hormones is oversecreted, often the second hormone is, too. The question posed is whether the increased secretion of growth hormone together with that of prolactin over long periods of time is a risk factor for malignancy.
authors.affiliation: Endocrinology & Diabetes Research Unit, Schneider Children's Medical Center and Sackler School of Medicine, Tel Aviv University, Israel. laronz@clalit.org.il
authors.forename: Zvi
authors.initials: Z
authors.lastname: Laron
mesh_terms: D000236:Adenoma / Q000097:blood / Q000209:etiology / Q000378:metabolism; D000818:Animals; D002648:Child; D013006:Growth Hormone / Q000097:blood / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D052682:Lactotrophs / Q000378:metabolism / Q000502:physiology; D010911:Pituitary Neoplasms / Q000097:blood / Q000209:etiology / Q000378:metabolism; D011388:Prolactin / Q000097:blood / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D052683:Somatotrophs / Q000378:metabolism / Q000502:physiology; D013234:Stem Cells / Q000378:metabolism / Q000502:physiology
chemical_list: D007334:Insulin-Like Growth Factor I; D011388:Prolactin; D013006:Growth Hormone