title: Bayesian hemodynamic parameter estimation by bolus tracking perfusion weighted imaging.
abstract: A delay-insensitive probabilistic method for estimating hemodynamic parameters, delays, theoretical residue functions, and concentration time curves by computed tomography (CT) and magnetic resonance (MR) perfusion weighted imaging is presented. Only a mild stationarity hypothesis is made beyond the standard perfusion model. New microvascular parameters with simple hemodynamic interpretation are naturally introduced. Simulations on standard digital phantoms show that the method outperforms the oscillating singular value decomposition (oSVD) method in terms of goodness-of-fit, linearity, statistical and systematic errors on all parameters, especially at low signal-to-noise ratios (SNRs). Delay is always estimated sharply with user-supplied resolution and is purely arterial, by contrast to oSVD time-to-maximum TMAX that is very noisy and biased by mean transit time (MTT), blood volume, and SNR. Residue functions and signals estimates do not suffer overfitting anymore. One CT acute stroke case confirms simulation results and highlights the ability of the method to reliably estimate MTT when SNR is low. Delays look promising for delineating the arterial occlusion territory and collateral circulation.
authors.affiliation: Department of Research and Innovation, Olea Medical, 13600 La Ciotat, France. timothe. boutelier@oleamedical.com
authors.forename: Timothé
authors.initials: T
authors.lastname: Boutelier
authors.forename: Koshuke
authors.initials: K
authors.lastname: Kudo
authors.forename: Fabrice
authors.initials: F
authors.lastname: Pautot
authors.forename: Makoto
authors.initials: M
authors.lastname: Sasaki
mesh_terms: D000368:Aged; D000465:Algorithms; D001499:Bayes Theorem; D001931:Brain Mapping / Q000379:methods; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003198:Computer Simulation; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D055420:Perfusion Imaging / Q000379:methods*; D019047:Phantoms, Imaging; D012815:Signal Processing, Computer-Assisted; D059629:Signal-To-Noise Ratio; D020521:Stroke / Q000473:pathology; D014057:Tomography, X-Ray Computed / Q000379:methods*