title: Impact of antiepileptic drugs on genesis of psychosis.
abstract: Opinions regarding the impact of antiepileptic drugs (AEDs) on the genesis of psychotic symptoms are varied. To re-examine this issue, the records of adult patients with partial epilepsy and newly added AEDs were retrospectively surveyed. The types of newly added AEDs and clinical characteristics were compared between 38 patients with active psychosis and 212 without psychotic history during a follow-up period of 3 to 6 months after initiation of AED administration. Using multivariate logistic regression analysis, the significance of possible predictive variables for development of psychosis was evaluated, which demonstrated that use of zonisamide (ZNS) and phenytoin (PHT), presence of complex partial seizures (CPS), and low intelligence level were significantly correlated with psychosis. We concluded that ZNS and PHT are possible risk factors for development of psychosis along with clinical variables, including the presence of CPS and low intelligence level.
authors.affiliation: Department of Neuropsychiatry, Aichi Medical University, 21 Yazako-Karimata, Nagakute, 480-1195 Aichi, Japan. nogchanchyn@gmail.com
authors.forename: Takahiro
authors.initials: T
authors.lastname: Noguchi
authors.forename: Naofumi
authors.initials: N
authors.lastname: Fukatsu
authors.forename: Hiroko
authors.initials: H
authors.lastname: Kato
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Oshima
authors.forename: Kousuke
authors.initials: K
authors.lastname: Kanemoto
mesh_terms: D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D017029:Epilepsy, Complex Partial / Q000188:drug therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D038801:International Classification of Diseases; D007555:Isoxazoles / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D010672:Phenytoin / Q000009:adverse effects*; D011618:Psychotic Disorders / Q000175:diagnosis / Q000209:etiology*; D012189:Retrospective Studies; D055815:Young Adult; D000078305:Zonisamide
chemical_list: D000927:Anticonvulsants; D007555:Isoxazoles; D000078305:Zonisamide; D010672:Phenytoin