title: Whole-genome QTL scan for ultrasound and carcass merit traits in beef cattle using Bayesian shrinkage method.
abstract: Fine mapping of quantitative trait loci (QTL) for 16 ultrasound measurements and carcass merit traits that were collected from 418 hybrid steers was conducted using 1207 SNP markers covering the entire genome. These SNP markers were evaluated using a Bayesian shrinkage estimation method and the empirical critical significant thresholds (α = 0.05 and α = 0.01) were determined by permutation based on 3500 permuted datasets for each trait to control the genome-wide type I error rates. The analyses identified a total of 105 QTLs (p < 0.05) for seven ultrasound measure traits including ultrasound backfat, ultrasound marbling and ultrasound ribeye area and 113 QTLs for seven carcass merit traits of carcass weight, grade fat, average backfat, ribeye area, lean meat yield, marbling and yield grade. Proportion of phenotypic variance accounted for by a single QTL ranged from 0.06% for mean ultrasound backfat to 4.83% for carcass marbling (CMAR) score, while proportion of the phenotypic variance accounted for by all significant (p < 0.05) QTL identified for a single trait ranged from 4.54% for carcass weight to 23.87% for CMAR.
authors.affiliation: Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, Alberta, Canada.
authors.forename: S M
authors.initials: SM
authors.lastname: Nalaila
authors.forename: P
authors.initials: P
authors.lastname: Stothard
authors.forename: S S
authors.initials: SS
authors.lastname: Moore
authors.forename: C
authors.initials: C
authors.lastname: Li
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
mesh_terms: D000818:Animals; D001499:Bayes Theorem; D001837:Body Weights and Measures; D002417:Cattle / Q000235:genetics* / Q000502:physiology; D055106:Genome-Wide Association Study; D008460:Meat / Q000032:analysis; D020641:Polymorphism, Single Nucleotide; D040641:Quantitative Trait Loci