title: Paraventricular nucleus anandamide signaling alters eating and substrate oxidation.
abstract: In the central nervous system, the endocannabinoid anandamide [N-arachidonoylethanolamine (AEA)] is believed to increase food intake through on-demand activation of hypothalamic circuits. The present study examined the effects of hypothalamic paraventricular nucleus (PVN) injections of AEA (25-400 pmol) on food intake and energy substrate oxidation [respiratory quotient (RQ)]. PVN administration of AEA increased eating behavior and RQ, indicating enhanced carbohydrate oxidation. Further, PVN administration of the cannabinoid type 1 receptor inverse agonist AM251 (5-10 μg) attenuated both the eating and the RQ responses elicited by AEA (100 pmol). AM251 administered alone did not alter food intake or RQ. Overall, these findings are consistent with a role for PVN cannabinoid type 1 receptors in the regulation of eating and energy homeostasis.
authors.affiliation: Department of Psychology, Reed College, 3203 SE Woodstock Blvd, Portland, Oregon 97202, USA.
authors.forename: Colin D
authors.initials: CD
authors.lastname: Chapman
authors.forename: Lindsey M
authors.initials: LM
authors.lastname: Dono
authors.forename: Matthew C
authors.initials: MC
authors.lastname: French
authors.forename: Zachary Y
authors.initials: ZY
authors.lastname: Weinberg
authors.forename: Lindsey M
authors.initials: LM
authors.lastname: Schuette
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Currie
mesh_terms: D000818:Animals; D001095:Arachidonic Acids / Q000494:pharmacology*; D063386:Cannabinoid Receptor Agonists; D004435:Eating / Q000187:drug effects*; D063388:Endocannabinoids; D004734:Energy Metabolism / Q000187:drug effects*; D008297:Male; D010084:Oxidation-Reduction; D010286:Paraventricular Hypothalamic Nucleus / Q000187:drug effects* / Q000378:metabolism; D010880:Piperidines / Q000494:pharmacology; D053284:Polyunsaturated Alkamides; D011720:Pyrazoles / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D043882:Receptors, Cannabinoid / Q000378:metabolism
chemical_list: D001095:Arachidonic Acids; D063386:Cannabinoid Receptor Agonists; D063388:Endocannabinoids; D010880:Piperidines; D053284:Polyunsaturated Alkamides; D011720:Pyrazoles; D043882:Receptors, Cannabinoid; C103505:AM 251; C078814:anandamide