title: Collagen VI encodes antimicrobial activity: novel innate host defense properties of the extracellular matrix.
abstract: Collagen type VI is a subepithelial extracellular matrix component in airways and an adhesive substrate for oral pathogens [Bober et al.: J Innate Immun 2010;2:160-166]. Here, we report that collagen VI displays a dose-dependent antimicrobial activity against group A, C, and G streptococci by membrane disruption in physiological conditions. The data disclose previously unrecognized aspects of the extracellular matrix in innate host defense.
authors.affiliation: Division of Infection Medicine, Department of Clinical Sciences, Biomedical Center, Lund University, Lund, Sweden.
authors.forename: Suado M
authors.initials: SM
authors.lastname: Abdillahi
authors.forename: Selma
authors.initials: S
authors.lastname: Balvanović
authors.forename: Maria
authors.initials: M
authors.lastname: Baumgarten
authors.forename: Matthias
authors.initials: M
authors.lastname: Mörgelin
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D024142:Collagen Type VI / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D005109:Extracellular Matrix / Q000737:chemistry / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D008826:Microbial Sensitivity Tests; D013291:Streptococcus / Q000145:classification / Q000187:drug effects*; D013297:Streptococcus pyogenes / Q000187:drug effects*
chemical_list: D000890:Anti-Infective Agents; D024142:Collagen Type VI