title: [Drug-induced osteoporosis].
abstract: Optimal care of patients at risk of osteoporosis (low bone density and/or fracture) requires the assessment of risk factors of osteoporosis and fracture (lifestyle risk factors, chronic diseases and drugs). Among drugs, prior and current use of oral corticosteroids is strongly associated with an increased risk of fractures. But other medications could be involved and should be assessed in patients at risk of fractures. There are a strong evidence for GnRH agonists and aromatase inhibitors, antiepileptic, selective serotonin reuptake inhibitors, proton pump inhibitors. Further studies are necessary to confirm bone deleterious effect of other treatments.
authors.affiliation: Université Paris-Descartes, service de rhumatologie, hôpital Cochin, AP-HP, 75014 Paris. karine.briot@cch.aphp.fr
authors.forename: Karine
authors.initials: K
authors.lastname: Briot
mesh_terms: D000305:Adrenal Cortex Hormones / Q000009:adverse effects / Q000627:therapeutic use; D015519:Bone Density / Q000187:drug effects; D002491:Central Nervous System Agents / Q000009:adverse effects; D064420:Drug-Related Side Effects and Adverse Reactions; D050723:Fractures, Bone / Q000453:epidemiology / Q000209:etiology; D006727:Hormone Antagonists / Q000009:adverse effects; D006801:Humans; D010024:Osteoporosis / Q000139:chemically induced* / Q000150:complications / Q000453:epidemiology; D054328:Proton Pump Inhibitors / Q000009:adverse effects; D012307:Risk Factors
chemical_list: D000305:Adrenal Cortex Hormones; D002491:Central Nervous System Agents; D006727:Hormone Antagonists; D054328:Proton Pump Inhibitors