title: Effect of polymerized human placenta hemoglobin on hemodynamic parameter and cardiac function in a rat hemorrhagic shock model.
abstract: To investigate whether polymerized human placenta hemoglobin (PolyPHb) improved hemodynamic parameter recovery and cardiac function after hemorrhagic shock, a mean arterial pressure (MAP) of 30 mmHg was maintained for 60min. Then, all the rats were randomly resuscitated with hetastarch (HES), shed blood (Whole Blood), or PolyPHb (PolyPHb). The MAP was greatly improved by PolyPHb, but it was still lower than that of the Whole Blood group. Meanwhile, the cardiac function and enzyme releases in the PolyPHb group were similar to the HES group. Therefore, our findings suggest that PolyPHb moderately improved hemodynamic recovery and provided little cardioprotective effect in hemorrhagic shock.
authors.affiliation: Laboratory of Anesthesiology and Translational Neuroscience Center, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.forename: Yongxian
authors.initials: Y
authors.lastname: Jiang
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Zhang
authors.forename: Sisi
authors.initials: S
authors.lastname: Zhang
authors.forename: Wei
authors.initials: W
authors.lastname: Wu
authors.forename: Daqin
authors.initials: D
authors.lastname: Liao
authors.forename: Yanfang
authors.initials: Y
authors.lastname: Chen
authors.forename: Chengmin
authors.initials: C
authors.lastname: Yang
authors.forename: Xuewen
authors.initials: X
authors.lastname: Xu
authors.forename: Jin
authors.initials: J
authors.lastname: Liu
mesh_terms: D000818:Animals; D001704:Biopolymers / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D001802:Blood Substitutes / Q000494:pharmacology*; D004195:Disease Models, Animal; D005260:Female; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology*; D006439:Hemodynamics / Q000187:drug effects*; D006454:Hemoglobins / Q000494:pharmacology*; D006801:Humans; D008297:Male; D010477:Perfusion; D010920:Placenta / Q000737:chemistry*; D011247:Pregnancy; D051381:Rats; D017207:Rats, Sprague-Dawley; D020127:Recovery of Function / Q000187:drug effects; D012771:Shock, Hemorrhagic / Q000503:physiopathology*
chemical_list: D001704:Biopolymers; D001802:Blood Substitutes; D006454:Hemoglobins; C079129:hemoglobin polymer