title: Prediction of ADHD to anxiety disorders: an 11-year national insurance data analysis in Taiwan.
abstract: OBJECTIVE
  To prospectively investigate prediction of ADHD to anxiety disorders (ANXs) in a national sample of Taiwan.
  
  
  METHODS
  From the Taiwan National Health Insurance Dataset (1997-2007), we collected 2,385 cases of new diagnoses of ADHD from 1999 to 2003 and 9,540 sex-, age- and index dates of the first diagnosis of ADHD-matched cohort controls without ADHD. The outcome is age of the first diagnosis of ANXs until December 31, 2007.
  
  
  RESULTS
  More cases of ADHD (17.7%) developed ANXs than did matched controls (1.9%) with a younger age onset (12.7 years vs. 17.9 years) and a shorter "survival time" (1.4 years vs. 5.0 years). Cox models revealed a significant prediction of ADHD to ANXs controlling for other psychiatric comorbidities [Hazard ratio (HR) = 15.83]. The magnitude of such association was greater in males and decreased with older age of first ADHD diagnosis.
  
  
  CONCLUSIONS
  The findings imply that early detection and treatment for ADHD may offset later development of ANXs.
authors.affiliation: 1Taipei Medical University, Taipei, Taiwan.
authors.forename: Yueh-Ming
authors.initials: YM
authors.lastname: Tai
authors.forename: Churn-Shiouh
authors.initials: CS
authors.lastname: Gau
authors.forename: Susan Shur-Fen
authors.initials: SS
authors.lastname: Gau
authors.forename: Hung-Wen
authors.initials: HW
authors.lastname: Chiu
mesh_terms: D000293:Adolescent; D001008:Anxiety Disorders / Q000150:complications / Q000453:epidemiology*; D001289:Attention Deficit Disorder with Hyperactivity / Q000150:complications / Q000453:epidemiology*; D002648:Child; D015897:Comorbidity; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D013624:Taiwan / Q000208:ethnology