title: Linear growth and circulating insulin-like growth factor I in children with tufting enteropathy receiving long-term TPN.
abstract: We analyzed the growth of 12 children with tufting enteropathy for 2 years receiving total parenteral nutrition (TPN). At diagnosis, the length standard deviation score (SDS) (-2.15 ± 1.8) and body mass index (BMI) (12.6 ± 3.9) were significantly decreased. The height SDS and BMI of patients increased significantly (-1.39 ± 1.5 and 16.2 ± 1.9, respectively) after TPN. Partial catch-up growth was achieved in 7 of 12 children during the 2-year period, whereas linear growth velocity was maintained in an additional 3 patients. Insulin-like growth factor I levels correlated significantly with albumin and hemoglobin concentrations (P < 0.001), and increments in insulin-like growth factor I concentration after TPN were correlated with the changes in the BMI and height SDS (P < 001).
authors.affiliation: Department of Pediatrics, Hamad General Hospital, Doha, Qatar. ATSOLIMAN@yahoo.com
authors.forename: Ashraf T
authors.initials: AT
authors.lastname: Soliman
authors.forename: Hatem
authors.initials: H
authors.lastname: Abdel Rahman
authors.forename: Wail Said
authors.initials: WS
authors.lastname: Ali
authors.forename: Ahmed
authors.initials: A
authors.lastname: Elawwa
authors.forename: Nada
authors.initials: N
authors.lastname: Al-Arag
authors.forename: Hoda M
authors.initials: HM
authors.lastname: Badran
mesh_terms: D000418:Albumins / Q000378:metabolism; D001827:Body Height / Q000187:drug effects*; D015992:Body Mass Index; D002675:Child, Preschool; D006128:Growth / Q000187:drug effects*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007223:Infant; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D007410:Intestinal Diseases / Q000097:blood / Q000628:therapy*; D010289:Parenteral Nutrition, Total
chemical_list: D000418:Albumins; D006454:Hemoglobins; D007334:Insulin-Like Growth Factor I