title: Histological evaluation of rat larynx in experimental polycystic ovary syndrome model.
abstract: This study aimed at studying the histopathological effects of hyperandrogenemia and estrogen deficiency on larynx mucosa in experimentally designed polycystic ovary syndrome of female rats. Two groups of experimental polycystic ovary syndrome model were composed in healthy female rats by per oral letrozole administration of for 21 and 42 days. Also a control group which only took vehicle (saline) for 42 days was designed. Laryngeal mucosa and ovaries of all animals were examined histopathologically by light microscopy and the serum hormone levels were analyzed using a solid-phase, two-site chemiluminescent enzyme immunometric assay. Statistically significant edema, vascular engorgement, inflammation, cilia loss and differentiation of goblet cell distribution were observed when the control group and study groups were compared (p < 0.01). In serum hormonal analysis there was a significant increase in levels of androgens and decrease in levels of estrogens. In addition, polycystic appearance of ovaries in letrozole-administered groups and normal appearance of ovaries in control group have been proven histopathologically. Polycystic ovary syndrome which causes estrogen deficiency and hyperandrogenemia in fertile ages resulted in histopathological changes in laryngeal mucosa.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Fatih Sultan Mehmet Education and Research Hospital, E-5 üzeri Bostancı, 34744 Istanbul, Turkey. deveci2006@yahoo.com
authors.forename: Hande Senem
authors.initials: HS
authors.lastname: Deveci
authors.forename: Ildem
authors.initials: I
authors.lastname: Deveci
authors.forename: Mehmet
authors.initials: M
authors.lastname: Habesoglu
authors.forename: Mehmet
authors.initials: M
authors.lastname: Sürmeli
authors.forename: Vefa
authors.initials: V
authors.lastname: Kınıs
authors.forename: Murat
authors.initials: M
authors.lastname: Eriman
authors.forename: Pembegul
authors.initials: P
authors.lastname: Gunes
authors.forename: Murat
authors.initials: M
authors.lastname: Yekrek
authors.forename: Erol
authors.initials: E
authors.lastname: Egeli
mesh_terms: D000818:Animals; D016022:Case-Control Studies; D002923:Cilia / Q000473:pathology; D004195:Disease Models, Animal; D004958:Estradiol / Q000097:blood; D005260:Female; D020397:Goblet Cells / Q000473:pathology; D017588:Hyperandrogenism / Q000209:etiology / Q000473:pathology*; D007820:Laryngeal Mucosa / Q000473:pathology*; D010053:Ovary / Q000473:pathology; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar; D013739:Testosterone / Q000097:blood
chemical_list: D013739:Testosterone; D004958:Estradiol