title: Microenvironment-centred dynamics in aggressive B-cell lymphomas.
abstract: Aggressive B-cell lymphomas share high proliferative and invasive attitudes and dismal prognosis despite heterogeneous biological features. In the interchained sequence of events leading to cancer progression, neoplastic clone-intrinsic molecular events play a major role. Nevertheless, microenvironment-related cues have progressively come into focus as true determinants for this process. The cancer-associated microenvironment is a complex network of nonneoplastic immune and stromal cells embedded in extracellular components, giving rise to a multifarious crosstalk with neoplastic cells towards the induction of a supportive milieu. The immunological and stromal microenvironments have been classically regarded as essential partners of indolent lymphomas, while considered mainly negligible in the setting of aggressive B-cell lymphomas that, by their nature, are less reliant on external stimuli. By this paper we try to delineate the cardinal microenvironment-centred dynamics exerting an influence over lymphoid clone progression in aggressive B-cell lymphomas.
authors.affiliation: Dipartimento di Scienze per la Promozione della Salute, Sezione di Anatomia Patologica, Università degli Studi di Palermo, 90127 Palermo, Italy.
authors.forename: Matilde
authors.initials: M
authors.lastname: Cacciatore
authors.forename: Carla
authors.initials: C
authors.lastname: Guarnotta
authors.forename: Marco
authors.initials: M
authors.lastname: Calvaruso
authors.forename: Sabina
authors.initials: S
authors.lastname: Sangaletti
authors.forename: Ada Maria
authors.initials: AM
authors.lastname: Florena
authors.forename: Vito
authors.initials: V
authors.lastname: Franco
authors.forename: Mario Paolo
authors.initials: MP
authors.lastname: Colombo
authors.forename: Claudio
authors.initials: C
authors.lastname: Tripodo