title: Construction of polycyclic spiro-indolines via an intramolecular oxidative coupling/cyclization cascade reaction process.
abstract: An efficient protocol for assembling a polycyclic spiroindoline scaffold is developed, which involves an intramolecular oxidative coupling of dianions derived from indole-embodied β-ketoamides using iodine as the oxidant, and subsequent attack of oxygen anion to the resultant imine moiety. A number of tetracyclic spiroindolines are prepared with moderate to good yields.
authors.affiliation: School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Fan
authors.forename: Weiqing
authors.initials: W
authors.lastname: Xie
authors.forename: Dawei
authors.initials: D
authors.lastname: Ma
mesh_terms: D002384:Catalysis; D003500:Cyclization; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D058451:Oxidative Coupling; D011084:Polycyclic Aromatic Hydrocarbons / Q000138:chemical synthesis* / Q000737:chemistry; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D007211:Indoles; D011084:Polycyclic Aromatic Hydrocarbons; D013141:Spiro Compounds; C057812:indoline