title: Dosimetric effects of jaw tracking in step-and-shoot intensity-modulated radiation therapy.
abstract: The purpose of this work was to determine the dosimetric benefit to normal tissues by tracking the multi-leaf collimator (MLC) apertures with the photon jaws in step-and-shoot intensity-modulated radiation therapy (IMRT) on the Varian 2100 platform. Radiation treatment plans for ten thoracic, three pediatric, and three head and neck cancer patients were converted to plans with the jaws tracking each segment's MLC apertures, and compared to the original plans in a commercial radiation treatment planning system (TPS). The change in normal tissue dose was evaluated in the new plan by using the parameters V5, V10, and V20 (volumes receiving 5, 10 and 20 Gy, respectively) in the cumulative dose-volume histogram for the following structures: total lung minus gross target volume, heart, esophagus, spinal cord, liver, parotids, and brainstem. To validate the accuracy of our beam model, MLC transmission was measured and compared to that predicted by the TPS. The greatest changes between the original and new plans occurred at lower dose levels. In all patients, the reduction in V20 was never more than 6.3% and was typically less than 1%; the maximum reduction in V5 was 16.7% and was typically less than 3%. The variation in normal tissue dose reduction was not predictable, and we found no clear parameters that indicated which patients would benefit most from jaw tracking. Our TPS model of MLC transmission agreed with measurements with absolute transmission differences of less than 0.1% and, thus, uncertainties in the model did not contribute significantly to the uncertainty in the dose determination. We conclude that the amount of dose reduction achieved by collimating the jaws around each MLC aperture in step-and-shoot IMRT is probably not clinically significant.
authors.affiliation: Department of Radiation Physics and The University of Texas Graduate School of Biomedical Sciences at Houston, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA. sjoy@mdanderson.org
authors.forename: Sarah
authors.initials: S
authors.lastname: Joy
authors.forename: George
authors.initials: G
authors.lastname: Starkschall
authors.forename: Stephen
authors.initials: S
authors.lastname: Kry
authors.forename: Mohammed
authors.initials: M
authors.lastname: Salehpour
authors.forename: R Allen
authors.initials: RA
authors.lastname: White
authors.forename: Steven H
authors.initials: SH
authors.lastname: Lin
authors.forename: Peter
authors.initials: P
authors.lastname: Balter
mesh_terms: D002648:Child; D004307:Dose-Response Relationship, Radiation; D006258:Head and Neck Neoplasms / Q000532:radiotherapy*; D006801:Humans; D007568:Jaw / Q000502:physiology / Q000528:radiation effects*; D011874:Radiometry; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D050397:Radiotherapy, Intensity-Modulated; D012189:Retrospective Studies; D013899:Thoracic Neoplasms / Q000532:radiotherapy*