title: Modulation of leptin resistance by protein tyrosine phosphatases.
abstract: Leptin plays a central role in weight control by suppressing food intake and increasing energy expenditure. The concept of leptin resistance emerged to explain the seemingly paradoxical elevated leptin levels in obesity. Recent discoveries reveal that protein tyrosine phosphatases are key players in leptin resistance by globally suppressing leptin signaling.
authors.affiliation: Goodman Cancer Research Centre, McGill University, Montreal, Quebec H3A 1A3, Canada. julie.st-pierre@mcgill.ca
authors.forename: Julie
authors.initials: J
authors.lastname: St-Pierre
authors.forename: Michel L
authors.initials: ML
authors.lastname: Tremblay
mesh_terms: D000818:Animals; D004435:Eating / Q000235:genetics / Q000502:physiology; D004734:Energy Metabolism / Q000235:genetics / Q000502:physiology; D006801:Humans; D020738:Leptin / Q000378:metabolism*; D017027:Protein Tyrosine Phosphatases / Q000235:genetics / Q000378:metabolism*
chemical_list: D020738:Leptin; D017027:Protein Tyrosine Phosphatases