title: Abibalsamins A and B, two new tetraterpenoids from Abies balsamea oleoresin.
abstract: Abibalsamins A (1) and B (2), two unprecedented tetraterpenoids featuring a 3,4-seco-rearranged lanostane system fused with a β-myrcene lateral chain via a [4 + 2] Diels-Alder cycloaddition, were isolated from the oleoresin of Abies balsamea. Their structures were elucidated by means of extensive 2D NMR, IR, and MS spectroscopy analyses. The absolute configuration of 1 was determined by single-crystal X-ray diffraction. Both compounds exhibited significant cytotoxic activity against cancer cell lines.
authors.affiliation: Université du Québec à Chicoutimi, Laboratoire d'Analyse et de Séparation des Essences Végétales (LASEVE), Département des Sciences Fondamentales, 555 boul. de l'Université, Chicoutimi (Québec), Canada, G7H 2B1.
authors.forename: Serge
authors.initials: S
authors.lastname: Lavoie
authors.forename: Jean
authors.initials: J
authors.lastname: Legault
authors.forename: Charles
authors.initials: C
authors.lastname: Gauthier
authors.forename: Vakhtang
authors.initials: V
authors.lastname: Mshvildadze
authors.forename: Sylvain
authors.initials: S
authors.lastname: Mercier
authors.forename: André
authors.initials: A
authors.lastname: Pichette
mesh_terms: D028202:Abies / Q000737:chemistry*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010946:Plants, Medicinal / Q000737:chemistry*; D013141:Spiro Compounds; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D013141:Spiro Compounds; D013729:Terpenes; C572541:abibalsamin A; C572543:abibalsamin B