title: Complex polymer brush gradients based on nanolithography and surface-initiated polymerization.
abstract: Confined surface gradients consisting of polymer brushes have great potential in various applications such as microfluidic devices, sensors, and biophysical research. Among the available fabrication approaches, nanolithographies combined with self-assembled monolayers and surface-initiated polymerization have became powerful tools to engineer confined gradients or predefined complex gradients on the nanometre size. In this tutorial review, we mainly highlight the research progress of the fabrication of confined polymer brush gradients by using electron beam, laser, and probe-based nanolithographies and the physical base for these approaches. The application of these polymer brush gradients in biomedical research is also addressed.
authors.affiliation: Key Laboratory of Microsystems and Microstructures Manufacturing, Ministry of Education, Micro/Nano Technology Research Centre, Harbin Institute of Technology, Yikuangjie No. 2, Harbin 150080, China.
authors.forename: Xiankun
authors.initials: X
authors.lastname: Lin
authors.forename: Qiang
authors.initials: Q
authors.lastname: He
authors.forename: Junbai
authors.initials: J
authors.lastname: Li