title: Tissue factor and thrombin in sickle cell anemia.
abstract: Sickle cell anemia is an inherited hematologic disorder associated with hemolytic and vaso-occlusive complications. An activation of coagulation is also a prominent feature of sickle cell anemia. Growing evidence indicates that coagulation may contribute to the inflammation and vascular injury in sickle cell anemia. This review focuses on tissue factor expression and its contribution to the activation of coagulation, thrombosis and vascular inflammation in sickle cell anemia.
authors.affiliation: Department of Medicine, Division of Hematology and Oncology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
authors.forename: Pichika
authors.initials: P
authors.lastname: Chantrathammachart
authors.forename: Rafal
authors.initials: R
authors.lastname: Pawlinski
mesh_terms: D000755:Anemia, Sickle Cell / Q000097:blood*; D000818:Animals; D006801:Humans; D013917:Thrombin / Q000378:metabolism*; D013925:Thromboplastin / Q000378:metabolism*
chemical_list: D013925:Thromboplastin; D013917:Thrombin