title: Polycystic ovary syndrome: brain-derived neurotrophic factor (BDNF) plasma and follicular fluid levels.
abstract: Polycystic ovary syndrome is one of the most common endocrine disorders in women of reproductive age. Features of PCOS are hyperandrogenism, chronic anovulation and polycystic ovaries on ultrasonography. Follicle development is a complex and carefully orchestrated phenomenon, involving gonadotropins and a rapidly expanding list of other intraovarian regulators, such as brain-derived neurotrophic factor (BDNF). The aim of this study is to evaluate BDNF in plasma and in follicular fluid in women affected by PCOS and in normal menstruating women. In PCOS patients the BDNF levels in plasma and in follicular fluid are higher than values obtained in healthy controls. Therefore we can hypothsize that high levels of luteinizing hormone, probably increase the secretion of BDNF in PCOS patients.
authors.affiliation: Department of Reproductive Medicine and Child Development, Division of Gynaecology and Obstetrics, University of Pisa, Pisa, Italy. nataliarusso@libero.it
authors.forename: N
authors.initials: N
authors.lastname: Russo
authors.forename: M
authors.initials: M
authors.lastname: Russo
authors.forename: D
authors.initials: D
authors.lastname: Daino
authors.forename: F
authors.initials: F
authors.lastname: Bucci
authors.forename: N
authors.initials: N
authors.lastname: Pluchino
authors.forename: E
authors.initials: E
authors.lastname: Casarosa
authors.forename: P G
authors.initials: PG
authors.lastname: Artini
authors.forename: V
authors.initials: V
authors.lastname: Cela
authors.forename: M
authors.initials: M
authors.lastname: Luisi
authors.forename: A R
authors.initials: AR
authors.lastname: Genazzani
mesh_terms: D000293:Adolescent; D000328:Adult; D019208:Brain-Derived Neurotrophic Factor / Q000097:blood / Q000378:metabolism*; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D015571:Follicular Fluid / Q000378:metabolism*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000378:metabolism*; D011374:Progesterone / Q000097:blood; D055815:Young Adult
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D011374:Progesterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone