title: Functionalized synthetic biodegradable polymer scaffolds for tissue engineering.
abstract: Scaffolds (artificial ECMs) play a pivotal role in the process of regenerating tissues in 3D. Biodegradable synthetic polymers are the most widely used scaffolding materials. However, synthetic polymers usually lack the biological cues found in the natural extracellular matrix. Significant efforts have been made to synthesize biodegradable polymers with functional groups that are used to couple bioactive agents. Presenting bioactive agents on scaffolding surfaces is the most efficient way to elicit desired cell/material interactions. This paper reviews recent advancements in the development of functionalized biodegradable polymer scaffolds for tissue engineering, emphasizing the syntheses of functional biodegradable polymers, and surface modification of polymeric scaffolds.
authors.affiliation: Department of Biologic and Materials Sciences, University of Michigan, Ann Arbor, MI 48109, USA.
authors.forename: Xiaohua
authors.initials: X
authors.lastname: Liu
authors.forename: Jeremy M
authors.initials: JM
authors.lastname: Holzwarth
authors.forename: Peter X
authors.initials: PX
authors.lastname: Ma
mesh_terms: D001031:Apatites / Q000737:chemistry; D015415:Biomarkers / Q000032:analysis; D040761:Biomimetic Materials / Q000138:chemical synthesis* / Q000494:pharmacology; D002264:Carboxylic Acids / Q000737:chemistry*; D002478:Cells, Cultured; D048271:Chitosan / Q000737:chemistry*; D005109:Extracellular Matrix; D005780:Gelatin / Q000737:chemistry*; D015870:Gene Expression / Q000187:drug effects; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D010710:Phosphates / Q000737:chemistry*; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D013499:Surface Properties; D023822:Tissue Engineering
chemical_list: D001031:Apatites; D015415:Biomarkers; D002264:Carboxylic Acids; D010710:Phosphates; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D005780:Gelatin; D048271:Chitosan