title: Potential for use of 1,5-anhydroglucitol when initiating insulin therapy in people with type 2 diabetes and suboptimal control with oral antidiabetic drugs.
abstract: Endpoint HbA(1c) <7.0% was achieved by 80 (73.4%) lispro mix 25 (LM25)-treated patients and 67 (60.9%) glargine-treated patients (p=0.027) with baseline 1,5 anhydroglucitol (1,5AG) below median and 75 (70.8%) LM25-treated patients and 72 (63.7%) glargine-treated patients (p=0.238) with 1,5AG≥median, suggesting, 1,5AG may offer therapeutic insight when starting insulin therapy.
authors.affiliation: Ohio State University Medical Center, Columbus, OH, USA. Kathleen.Dungan@osumc.edu
authors.forename: Kathleen M
authors.initials: KM
authors.lastname: Dungan
authors.forename: John B
authors.initials: JB
authors.lastname: Buse
authors.forename: William H
authors.initials: WH
authors.lastname: Herman
authors.forename: Richard F
authors.initials: RF
authors.lastname: Arakaki
authors.forename: Honghua H
authors.initials: HH
authors.lastname: Jiang
authors.forename: Jennie G
authors.initials: JG
authors.lastname: Jacobson
authors.forename: Jessie L
authors.initials: JL
authors.lastname: Fahrbach
mesh_terms: D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D003847:Deoxyglucose / Q000008:administration & dosage / Q000627:therapeutic use*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000097:blood / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000069036:Insulin Glargine; D061268:Insulin Lispro / Q000008:administration & dosage / Q000627:therapeutic use*; D049528:Insulin, Long-Acting / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D015430:Weight Gain / Q000187:drug effects
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D061268:Insulin Lispro; D049528:Insulin, Long-Acting; D000069036:Insulin Glargine; C006584:1,5-anhydroglucitol; D003847:Deoxyglucose