title: A general and facile one-pot process of isothiocyanates from amines under aqueous conditions.
abstract: A general and facile one-pot protocol for the preparation of a broad range of alkyl and aryl isothiocyanates has been developed from their corresponding primary amines under aqueous conditions. This synthetic process involves an in situ generation of a dithiocarbamate salt from the amine substrate by reacting with CS(2) followed by elimination to form the isothiocyanate product with cyanuric acid as the desulfurylation reagent. The choice of solvent is of decisive importance for the successful formation of the dithiocarbamate salt particularly for highly electron-deficient substrates. This novel and economical method is suitable for scale-up activities.
authors.affiliation: College of Chemical Engineering and Materials Science, Zhejiang University of Technology, Hangzhou 310014, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Sun
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.forename: Jianping
authors.initials: J
authors.lastname: Shao
authors.forename: Weimin
authors.initials: W
authors.lastname: Mo
authors.forename: Baoxiang
authors.initials: B
authors.lastname: Hu
authors.forename: Zhenlu
authors.initials: Z
authors.lastname: Shen
authors.forename: Xinquan
authors.initials: X
authors.lastname: Hu