title: Cushing's disease as a cause of severe osteoporosis: a clinical challenge.
abstract: Secondary osteoporosis is a frequently underestimated bone disorder. It is a secondary cause of bone loss that affects more than half of men and premenopausal and perimenopausal women, and about one-fitfth of postmenopausal women. We herein report an uncommon case of multiple fractures due to secondary osteoporosis caused by Cushing's disease. In this case the appearance of fractures in a 41 years old woman was the sign of alarm that ultimately lead us to the diagnosis.
authors.affiliation: Servicio de Reumatología, Hospital Universitario Virgen Macarena, Sevilla, Spain. greendoggy@hotmail.com
authors.forename: Nadia
authors.initials: N
authors.lastname: Abdel-Kader
authors.forename: Mario H
authors.initials: MH
authors.lastname: Cardiel
authors.forename: Victoria
authors.initials: V
authors.lastname: Navarro Compan
authors.forename: Juan
authors.initials: J
authors.lastname: Piedra Priego
authors.forename: Ana
authors.initials: A
authors.lastname: González
mesh_terms: D049913:ACTH-Secreting Pituitary Adenoma / Q000150:complications / Q000175:diagnosis / Q000601:surgery; D000236:Adenoma / Q000150:complications / Q000175:diagnosis / Q000601:surgery; D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000328:Adult; D050071:Bone Density Conservation Agents / Q000627:therapeutic use; D004164:Diphosphonates / Q000627:therapeutic use; D005260:Female; D005598:Fractures, Spontaneous / Q000209:etiology; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D007016:Hypophysectomy / Q000379:methods; D007093:Imidazoles / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D010024:Osteoporosis / Q000188:drug therapy / Q000209:etiology*; D010384:Pelvic Bones; D047748:Pituitary ACTH Hypersecretion / Q000150:complications* / Q000378:metabolism; D012074:Remission Induction; D016103:Spinal Fractures / Q000209:etiology; D013249:Sternum; D013904:Thoracic Vertebrae; D000077211:Zoledronic Acid
chemical_list: D050071:Bone Density Conservation Agents; D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone