title: Diverse functions of uterine proteoglycans in human reproduction (review).
abstract: Proteoglycans (PGs) are a group of heavily glycosylated proteins that are present throughout the mammalian body and are involved in a wide variety of biological phenomena, including structural maintenance, tissue remodeling, molecular presentation, cell adhesion and signal transmission. Previous studies have revealed an increasing number of roles for PGs in human reproduction. Several PGs are currently utilized or regarded as biomarkers for the diagnosis of certain pathological uterine conditions associated with infertility and obstetrical complications. The aim of this review was to discuss the involvement of PGs in the human uterus in reproductive biology and pathophysiology.
authors.affiliation: IVF Center, Oak Clinic, Osaka, Japan.
authors.forename: Kotaro
authors.initials: K
authors.lastname: Kitaya
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Tada
authors.forename: Terumi
authors.initials: T
authors.lastname: Hayashi
authors.forename: Sagiri
authors.initials: S
authors.lastname: Taguchi
authors.forename: Miyako
authors.initials: M
authors.lastname: Funabiki
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Tadahiro
authors.initials: T
authors.lastname: Yasuo
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D004717:Endometrium / Q000378:metabolism; D005260:Female; D006801:Humans; D011509:Proteoglycans / Q000378:metabolism*; D012098:Reproduction / Q000502:physiology*; D053668:Syndecan-1 / Q000378:metabolism; D018180:Thrombomodulin / Q000378:metabolism; D014599:Uterus / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D011509:Proteoglycans; D053668:Syndecan-1; D018180:Thrombomodulin