title: Towards regenerative therapy for cardiac disease.
abstract: Development of regenerative therapeutic strategies to reverse the progression of advanced heart failure is one of the most urgent clinical needs of this century. Insights gained from clinical trials of adult stem cells, together with fundamental scientific advances in cardiac stem cell and regenerative biology, are beginning to yield potential new targets and strategies for regenerative therapies. Of particular importance are new scientific discoveries related to intrinsic cardiac regeneration, renewal factors that can trigger regeneration, and tissue-engineering technology, which are beginning to change the way investigators view the scientific and clinical position of cardiovascular regenerative therapy.
authors.affiliation: Cardiac Arrhythmia Service, Massachusetts General Hospital Heart Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
authors.forename: Leon M
authors.initials: LM
authors.lastname: Ptaszek
authors.affiliation: Cardiac Arrhythmia Service, Massachusetts General Hospital Heart Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
authors.forename: Moussa
authors.initials: M
authors.lastname: Mansour
authors.affiliation: Cardiac Arrhythmia Service, Massachusetts General Hospital Heart Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
authors.forename: Jeremy N
authors.initials: JN
authors.lastname: Ruskin
authors.affiliation: Cardiovascular Research Center, Massachusetts General Hospital, Boston, MA, USA; Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. Electronic address: kchien@harvard.edu.
authors.forename: Kenneth R
authors.initials: KR
authors.lastname: Chien
mesh_terms: D000818:Animals; D006321:Heart / Q000502:physiology*; D006333:Heart Failure / Q000628:therapy*; D006801:Humans; D032383:Myocytes, Cardiac / Q000637:transplantation; D039904:Pluripotent Stem Cells / Q000637:transplantation; D012038:Regeneration / Q000502:physiology*; D033581:Stem Cell Transplantation / Q000379:methods; D023822:Tissue Engineering / Q000379:methods; D014182:Transplantation, Autologous