title: Rituximab therapy prevents focal and segmental glomerulosclerosis recurrence after a second renal transplantation.
abstract: Preventive treatment of focal and segmental glomerulosclerosis (FSGS) allograft recurrence in high risk recipients having a prior history of graft loss caused by FSGS recurrence is still a challenging question. We retrospectively identified four patients who underwent a second renal transplantation because of recurrent FSGS and who received Rituximab therapy as a prophylactic treatment. Loss of their first allograft was directly related to an early (<3 months) recurrence of FSGS that was either resistant to plasmapheresis therapy in two cases or had escaped to this therapeutic management in the two others. After the second renal transplantation, all patients were free of FSGS recurrence during follow-ups that were between 12 and 54 months long. These preliminary results demonstrate for the first time that Rituximab therapy may constitute an attractive prophylactic option for patients being considered for a second renal transplantation because of recurrent FSGS in their first graft.
authors.affiliation: Service de Néphrologie et Transplantation, Hôpital Henri Mondor, AP-HP, Institut Francilien de recherche en Néphrologie et Transplantation (IFRNT), Paris Est Université Créteil, France.
authors.forename: Vincent
authors.initials: V
authors.lastname: Audard
authors.forename: Nassim
authors.initials: N
authors.lastname: Kamar
authors.forename: Dil
authors.initials: D
authors.lastname: Sahali
authors.forename: Isabelle
authors.initials: I
authors.lastname: Cardeau-Desangles
authors.forename: Sébastien
authors.initials: S
authors.lastname: Homs
authors.forename: Philippe
authors.initials: P
authors.lastname: Remy
authors.forename: Jessie
authors.initials: J
authors.lastname: Aouizerate
authors.forename: Marie
authors.initials: M
authors.lastname: Matignon
authors.forename: Lionel
authors.initials: L
authors.lastname: Rostaing
authors.forename: Philippe
authors.initials: P
authors.lastname: Lang
authors.forename: Philippe
authors.initials: P
authors.lastname: Grimbert
mesh_terms: D000293:Adolescent; D000328:Adult; D058846:Antibodies, Monoclonal, Murine-Derived / Q000627:therapeutic use*; D002648:Child; D005260:Female; D005923:Glomerulosclerosis, Focal Segmental / Q000517:prevention & control / Q000601:surgery* / Q000628:therapy*; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000276:immunology / Q000473:pathology; D008297:Male; D010956:Plasmapheresis; D012008:Recurrence; D012086:Reoperation; D012189:Retrospective Studies; D012307:Risk Factors; D000069283:Rituximab; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D000069283:Rituximab