title: Foxp3+ cells control Th2 responses in a murine model of atopic dermatitis.
abstract: The role of Foxp3+ regulatory T (Treg) cells in atopic dermatitis (AD) is still unclear. In a murine AD model, the number of Foxp3+ cells increased in the allergen-exposed skin area and in the secondary lymphoid organs. Both Foxp3+ and Foxp3- IL-10+ T cells accumulated at the site of allergen exposure, and CD103+ effector/memory Foxp3+ Treg cells expanded gradually in the lymph nodes throughout the sensitization protocol. The depletion of Foxp3+ Treg cells led to significantly exacerbated skin inflammation, including increased recruitment of inflammatory cells and expression of T helper type 2 cytokines, as well as elevated serum IgE levels. The effect of depleting Treg cells during epicutaneous sensitization was mirrored off by a stronger inflammatory response also in the lungs following airway challenge. Thus, Treg cells have an important role in controlling AD-like inflammation and the transfer of allergic skin inflammation to the lungs.
authors.affiliation: Unit of Immunotoxicology, Finnish Institute of Occupational Health, Helsinki, Finland. Nanna.Fyhrquist@ttl.fi
authors.forename: Nanna
authors.initials: N
authors.lastname: Fyhrquist
authors.forename: Sari
authors.initials: S
authors.lastname: Lehtimäki
authors.forename: Katharina
authors.initials: K
authors.lastname: Lahl
authors.forename: Terhi
authors.initials: T
authors.lastname: Savinko
authors.forename: Anna-Mari
authors.initials: AM
authors.lastname: Lappeteläinen
authors.forename: Tim
authors.initials: T
authors.lastname: Sparwasser
authors.forename: Henrik
authors.initials: H
authors.lastname: Wolff
authors.forename: Antti
authors.initials: A
authors.lastname: Lauerma
authors.forename: Harri
authors.initials: H
authors.lastname: Alenius
mesh_terms: D000818:Animals; D002465:Cell Movement / Q000276:immunology; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology; D003876:Dermatitis, Atopic / Q000276:immunology* / Q000473:pathology; D004167:Diphtheria Toxin / Q000276:immunology / Q000494:pharmacology; D004195:Disease Models, Animal; D005260:Female; D051858:Forkhead Transcription Factors / Q000235:genetics / Q000276:immunology*; D008168:Lung / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D010047:Ovalbumin / Q000276:immunology; D011014:Pneumonia / Q000276:immunology / Q000473:pathology; D012867:Skin / Q000276:immunology / Q000473:pathology; D050378:T-Lymphocytes, Regulatory / Q000166:cytology / Q000276:immunology; D018418:Th2 Cells / Q000166:cytology / Q000276:immunology*
chemical_list: D004167:Diphtheria Toxin; D051858:Forkhead Transcription Factors; C498833:Foxp3 protein, mouse; D010047:Ovalbumin