title: Electrophysiological responses to threat in youth with and without Posttraumatic Stress Disorder.
abstract: The current study was designed to examine event-related brain potentials and autonomic responses to pictures indicating threat, relative to non-threat, and acoustic startle reflexes in traumatized youth diagnosed with PTSD, relative to non-exposed children, before and after receiving psychotherapy. Children in the control group were individually yoked and demographically matched to the PTSD group. Both groups displayed enhanced late positive potentials and more prolonged heart rate deceleration to pictures indicating threat, relative to non-threat, and larger skin conductance responses to pictures indicating threat, relative to non-threat, at time one. At time two, controls appeared to habituate, as reflected by an overall attenuated skin conductance response, whereas the PTSD group showed little change. Across time points the PTSD group exhibited greater acoustic startle reflexes than the control group. Psychotherapy and symptom reduction was not associated with electrophysiology. Drawing from the adult literature, this study was an attempt to address the scarcity of research examining electrophysiological irregularities in childhood PTSD. The overall results suggest that children and adolescents allocate more attention to threat-related stimuli regardless of PTSD status, and exaggerated startle and a possible failure to habituate skin conductance responses to threat-related stimuli in youth with versus without PTSD.
authors.affiliation: University of Connecticut Health Center, Department of Psychiatry, Farmington, CT 06030, United States. dgrasso@uchc.edu
authors.forename: Damion J
authors.initials: DJ
authors.lastname: Grasso
authors.forename: Robert F
authors.initials: RF
authors.lastname: Simons
mesh_terms: D000293:Adolescent; D000374:Aggression / Q000502:physiology* / Q000523:psychology; D000704:Analysis of Variance; D001341:Autonomic Nervous System / Q000503:physiopathology*; D016022:Case-Control Studies; D002648:Child; D015928:Cognitive Behavioral Therapy; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D005712:Galvanic Skin Response / Q000502:physiology*; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D011613:Psychotherapy; D013216:Reflex, Startle / Q000502:physiology*; D013313:Stress Disorders, Post-Traumatic / Q000503:physiopathology / Q000523:psychology*