title: Dynamic kinetic resolution of 1,3-dihydro-2H-isoindole-1-carboxylic acid methyl ester: asymmetric transformations toward isoindoline carbamates.
abstract: Asymmetric syntheses of isoindoline carbamates have been successfully achieved through enzyme-mediated dynamic kinetic resolution processes and without requirement of metal or acid-base catalyst for the substrate racemization. Optically active carbamates were obtained in good yields and an excellent degree of stereoselectivity when  Pseudomonas cepacia  lipase (PSL) was used as biocatalyst, with diallyl or dibenzyl carbonates being both adequate reagents in alkoxycarbonylation reactions.
authors.affiliation: Departamento de Química Orgánica e Inorgánica, Instituto Universitario de Biotecnología de Asturias, Universidad de Oviedo, 33006 Oviedo, Spain.
authors.forename: Roberto
authors.initials: R
authors.lastname: Morán-Ramallal
authors.forename: Vicente
authors.initials: V
authors.lastname: Gotor-Fernández
authors.forename: Pedro
authors.initials: P
authors.lastname: Laborda
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Sayago
authors.forename: Carlos
authors.initials: C
authors.lastname: Cativiela
authors.forename: Vicente
authors.initials: V
authors.lastname: Gotor
mesh_terms: D016956:Burkholderia cepacia / Q000201:enzymology*; D002219:Carbamates / Q000138:chemical synthesis* / Q000737:chemistry; D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D054833:Isoindoles / Q000138:chemical synthesis* / Q000737:chemistry; D007700:Kinetics; D008049:Lipase / Q000378:metabolism*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D002219:Carbamates; D002264:Carboxylic Acids; D054833:Isoindoles; D008049:Lipase