title: Differential diagnostic performance of Rose Bengal Score Test in Sjøgren's syndrome patients.
abstract: Aim of the study was to evaluate the diagnostic performance of the Rose Bengal score test for Sjøgren's syndrome (SS), and to explore differences between other tests and examinations. All participants were examined, including (but not limited to) unstimulated (UWS) and stimulated (SWS) whole saliva, labial gland biopsy (LGB or focus score), ophthalmologic questionnaire (ocular surface disease index OSDI) and objective tests: Schirmer test 1 (Sch. 1), Schirmer test 2 (Sch.2), Tear Break-up Time (TBUT) test and Rose Bengal score (RBS). Data were analyzed using Mann Whitney U-test, Receiver Operating Characteristic analysis, with specificity and sensitivity calculations and Spearman's correlation test. ROC curves showed a poor diagnostic performance of TBUT and OSDI. Sch. 1, Sch.2 and LGB all exhibited a high diagnostic performance. RBS exhibited the best performance (sensitivity 100,00; specificity 100,00; AUC 1,000). Study reveals the scarce reliability of TBUT, OSDI and Sch.1, and emphasizes RBS as the test of choice in the SS diagnosis.
authors.affiliation: University of Zagreb, Dubrava University Hospital, Department of Ophthalmology, Zagreb, Croatia. i_knezovic@yahoo.com
authors.forename: Igor
authors.initials: I
authors.lastname: Knezović
authors.forename: Ivan
authors.initials: I
authors.lastname: Alajbeg
authors.forename: Dalibor
authors.initials: D
authors.lastname: Karlović
authors.forename: Josip
authors.initials: J
authors.lastname: Pavan
authors.forename: Nada
authors.initials: N
authors.lastname: Vrkić
authors.forename: Ana
authors.initials: A
authors.lastname: Bisćan
mesh_terms: D005260:Female; D006801:Humans; D008297:Male; D012372:ROC Curve; D012395:Rose Bengal; D012859:Sjogren's Syndrome / Q000175:diagnosis*
chemical_list: D012395:Rose Bengal