title: Assessment of P-wave dispersion in patients with isolated bicuspid aortic valve and its relationship with aortic elasticity.
abstract: OBJECTIVE
  We evaluated P-wave duration and P-wave dispersion (PWD) in patients with isolated bicuspid aortic valve (BAV) without significant valve dysfunction and investigated the relationship between P-wave measurements and aortic elasticity.
  
  
  METHODS
  This prospective study consisted of 39 patients with isolated BAV with normal ejection fraction and 29 age- and gender-matched healthy subjects. P-wave duration and P-wave dispersion were calculated on 12-lead electrocardiograms. Echocardiographic examination was performed and aortic elasticity parameters were calculated including aortic strain, aortic stiffness index, aortic distensibility, and aortic elastic modulus.
  
  
  RESULTS
  Patients with BAV had significantly greater Pmax and PWD compared to controls (128±11 vs. 115±11 msec, p=0.006; 70±10 vs. 66±13 msec, p=0.02, respectively), whereas Pmin was similar. Aortic strain and distensibility were significantly lower and aortic stiffness index and aortic elastic modulus were significantly greater in patients with BAV (for all, p=0.0001). In correlation analysis, Pmax was significantly correlated with aortic strain (r=-0.30, p=0.01), aortic distensibility (r=-0.27, p=0.02), aortic stiffness index (r=0.36, p=0.004), and aortic elastic modulus (r=0.38, p=0.003), while PWD was correlated with aortic strain (r=-0.23, p=0.05) and aortic elastic modulus (r=0.25, p=0.05).
  
  
  CONCLUSIONS
  Our data showed that isolated BAV without valve dysfunction was associated with prolonged P-wave duration and increased PWD, both of which were related to aortic elasticity parameters.
authors.affiliation: Department of Cardiology, Ankara Atatürk Education and Research Hospital, Ankara, Turkey.
authors.forename: Emine
authors.initials: E
authors.lastname: Bilen
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kurt
authors.forename: Ibrahim Halil
authors.initials: IH
authors.lastname: Tanboğa
authors.forename: Umran
authors.initials: U
authors.lastname: Koçak
authors.forename: Cenk
authors.initials: C
authors.lastname: Sarı
authors.forename: Hüseyin
authors.initials: H
authors.lastname: Ayhan
authors.forename: Telat
authors.initials: T
authors.lastname: Keleş
authors.forename: Engin
authors.initials: E
authors.lastname: Bozkurt
mesh_terms: D000328:Adult; D001021:Aortic Valve / Q000002:abnormalities*; D001022:Aortic Valve Insufficiency / Q000151:congenital / Q000000981:diagnostic imaging / Q000503:physiopathology; D016022:Case-Control Studies; D004452:Echocardiography; D004548:Elasticity; D004562:Electrocardiography; D005260:Female; D006329:Heart Conduction System; D006330:Heart Defects, Congenital / Q000000981:diagnostic imaging / Q000503:physiopathology; D006349:Heart Valve Diseases / Q000151:congenital / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D008297:Male; D011446:Prospective Studies; D012720:Severity of Illness Index; D018487:Ventricular Dysfunction, Left / Q000503:physiopathology