title: Effect of nonenzymatic glycosylation on the magnetic resonance imaging (MRI) contrast agent binding to human serum albumin.
abstract: Enhanced nonenzymatic glycosylation (NEG) of human serum albumin (HSA) is observed in diabetic patients. This modifies some of the physiological functions of HSA, as the binding of ligands. Some gadolinium complexes, commonly used as MRI contrast agents, have a high affinity for HSA, which enhances their efficacy. The aim of this study is to evaluate the possible influence of the NEG of HSA on its affinity for some gadolinium chelates.
authors.affiliation: Department of General, Organic and Biomedical Chemistry, NMR and Molecular Imaging Laboratory, University of Mons, 19 Avenue Maistriau, B-7000 Mons, Belgium.
authors.forename: Céline
authors.initials: C
authors.lastname: Henoumont
authors.forename: Sophie
authors.initials: S
authors.lastname: Laurent
authors.forename: Robert N
authors.initials: RN
authors.lastname: Muller
authors.forename: Luce
authors.initials: L
authors.lastname: Vander Elst
mesh_terms: D002614:Chelating Agents / Q000493:pharmacokinetics; D003287:Contrast Media / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000503:physiopathology; D005682:Gadolinium / Q000378:metabolism; D019786:Gadolinium DTPA / Q000031:analogs & derivatives / Q000378:metabolism; D006031:Glycosylation; D006801:Humans; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods; D009942:Organometallic Compounds / Q000378:metabolism; D012709:Serum Albumin / Q000378:metabolism*
chemical_list: D002614:Chelating Agents; D003287:Contrast Media; C112668:MP 2269; D009942:Organometallic Compounds; D012709:Serum Albumin; C073590:gadolinium ethoxybenzyl DTPA; D005682:Gadolinium; D019786:Gadolinium DTPA; C109932:gadofosveset trisodium