title: Electroplated porous polypyrrole nanostructures patterned by colloidal lithography for drug-delivery applications.
abstract: Porous nanostructures of polypyrrole (Ppy) were fabricated using colloidal lithography and electrochemical techniques for potential applications in drug delivery. A sequential fabrication method was developed and optimized to maximize the coverage of the Ppy nanostructures and to obtain a homogeneous layer over the substrate. This was realized by masking with electrophoretically-assembled polystyrene (PS) nanospheres and then electroplating. Drug/biomolecule adsorption and the release characteristics for the porous nanostructures of Ppy were investigated using rhodamine B (Rh-B). Rh-B is an easily detectable small hydrophobic molecule that is used as a model for many drugs or biological substances. The porous Ppy nanostructures with an enhanced surface area exhibited higher Rh-B loading capacity than bulk planar films of Ppy. Moreover, tunability of surface morphology for further applications (e.g., sensing, cell adhesion) was demonstrated.
authors.affiliation: Multi-Scale Robotics Lab/Institute of Robotics and Intelligent Systems, ETH Zurich, 8092 Zurich, Switzerland.
authors.forename: J
authors.initials: J
authors.lastname: Pokki
authors.forename: O
authors.initials: O
authors.lastname: Ergeneman
authors.forename: K M
authors.initials: KM
authors.lastname: Sivaraman
authors.forename: B
authors.initials: B
authors.lastname: Ozkale
authors.forename: M A
authors.initials: MA
authors.lastname: Zeeshan
authors.forename: T
authors.initials: T
authors.lastname: Lühmann
authors.forename: B J
authors.initials: BJ
authors.lastname: Nelson
authors.forename: S
authors.initials: S
authors.lastname: Pané
mesh_terms: D000327:Adsorption; D003102:Colloids / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D049329:Nanostructures / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D011137:Polystyrenes / Q000737:chemistry; D016062:Porosity; D011758:Pyrroles / Q000737:chemistry*; D012235:Rhodamines / Q000737:chemistry
chemical_list: D003102:Colloids; D004337:Drug Carriers; D011108:Polymers; D011137:Polystyrenes; D011758:Pyrroles; D012235:Rhodamines; C067635:polypyrrole; C029773:rhodamine B