title: Nuclear receptors and AMPK: resetting metabolism.
abstract: Obesity, and in particular central adiposity, is a key feature of metabolic syndrome, which includes trends toward increased triglycerides, insulin resistance, high blood pressure, hypercholesterolemia, and heart disease. It has a prevalence of 25% or more and is a dominant component of the health care budgets in Western societies. In addition to genetic causes, high-fat diets and disrupted sleep patterns have major influences on the development of metabolic syndrome. Recent studies have demonstrated active roles for the nuclear receptor superfamily and the energy-sensing kinase adenosine monophosphate (AMP)-activated protein kinase (AMPK) in regulating metabolism and circadian rhythm. In this chapter, we review these findings and attempt to develop a better understanding of the interplay between metabolism and circadian rhythm and their coordinated regulation by nuclear receptors and AMPK. This supraregulatory network may be considered a target for novel therapeutic applications against metabolic syndrome.
authors.affiliation: Gene Expression Laboratory, Howard Hughes Medical Institute, The Salk Institute for Biological Studies, La Jolla, California 92037, USA.
authors.forename: W
authors.initials: W
authors.lastname: Fan
authors.forename: M
authors.initials: M
authors.lastname: Downes
authors.forename: A
authors.initials: A
authors.lastname: Atkins
authors.forename: R
authors.initials: R
authors.lastname: Yu
authors.forename: R M
authors.initials: RM
authors.lastname: Evans
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000378:metabolism*; D000818:Animals; D002940:Circadian Rhythm / Q000502:physiology; D006801:Humans; D053858:Metabolic Networks and Pathways; D020239:Receptor Cross-Talk; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism*
chemical_list: D018160:Receptors, Cytoplasmic and Nuclear; D055372:AMP-Activated Protein Kinases