title: Synthesis of fused dihydropyrano(furano)pyridines via [4 + 2]-cycloaddition of 5-alkenoxy substituted oxazoles.
abstract: A three-step procedure to access fused pyridines has been developed utilizing inexpensive amino acids and alkenols to form the key oxazole precursors. Yields are good to excellent and provide a rapid and inexpensive route to a range of pharmacologically and biologically valuable fused pyridines with difficult to access substitution patterns.
authors.affiliation: Chemical Development-Synthetic Chemistry, GlaxoSmithKline R&D, 709 Swedeland Road, King of Prussia, Pennsylvania 19406, United States.
authors.forename: Steven N
authors.initials: SN
authors.lastname: Goodman
authors.forename: Douglas M
authors.initials: DM
authors.lastname: Mans
authors.forename: Joseph
authors.initials: J
authors.lastname: Sisko
authors.forename: Hao
authors.initials: H
authors.lastname: Yin
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D015394:Molecular Structure; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000596:Amino Acids; D010080:Oxazoles; D011725:Pyridines