title: New biodegradable small-diameter artificial vascular prosthesis: a feasibility study.
abstract: An in-house built instrument was used to fabricate a small internal diameter (2 mm) artificial vascular prosthesis from biodegradable chitosan. This new artificial vascular prosthesis has shown a good biocompatibility based on the studies of its cell compatibility, inflammatory reaction, and platelet adhesion. In an animal test, the prosthesis was used to replace a 4-cm-long section of femoral artery in each of the seven tested dogs. The patency of the replacement was monitored at regular intervals using Doppler ultrasound diagnostics. Nine months after the implantation, hematoxylin and eosin staining, immunohistochemical study, and scanning electron microscope observation were carried out. Complete decomposition of the prosthesis and replacement by a natural blood vessel were observed. The results suggests that the artificial vascular prosthesis displays many characteristics of the "ideal" small-diameter artificial vascular, and have the biocompatibility that can be tailored to match those desired in vascular replacement application.
authors.affiliation: College of Marine Life Sciences, Ocean University of China, China, Qingdao.
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Kong
authors.forename: Baoqin
authors.initials: B
authors.lastname: Han
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Ye
authors.initials: Y
authors.lastname: Liang
authors.forename: Kai
authors.initials: K
authors.lastname: Shao
authors.forename: Wanshun
authors.initials: W
authors.lastname: Liu
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000378:metabolism*; D001792:Blood Platelets / Q000166:cytology; D001807:Blood Vessel Prosthesis; D019917:Blood Vessel Prosthesis Implantation; D002460:Cell Line; D048271:Chitosan / Q000378:metabolism*; D004285:Dogs; D005240:Feasibility Studies; D005260:Female; D005263:Femoral Artery / Q000601:surgery* / Q000648:ultrastructure; D006801:Humans; D008422:Materials Testing; D014654:Vascular Patency
chemical_list: D001672:Biocompatible Materials; D048271:Chitosan