title: Using graphene oxide high near-infrared absorbance for photothermal treatment of Alzheimer's disease.
abstract: A novel strategy to dissociate amyloid aggregation is presented, using localised heat generation from a clinically used amyloid staining dye, thioflavin-S (ThS)-modified graphene oxide (GO) under NIR laser irradiation. Compared to traditional chemotherapies, photothermal therapy shows reduced side effects and improved selectivity and safety.
authors.affiliation: Division of Biological Inorganic Chemistry, State Key Laboratory of Rare Earth Resource Utilization, Graduate School of the Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, Jilin, PR China.
authors.forename: Meng
authors.initials: M
authors.lastname: Li
authors.forename: Xinjian
authors.initials: X
authors.lastname: Yang
authors.forename: Jinsong
authors.initials: J
authors.lastname: Ren
authors.forename: Konggang
authors.initials: K
authors.lastname: Qu
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Qu
mesh_terms: D000544:Alzheimer Disease / Q000378:metabolism / Q000628:therapy*; D000682:Amyloid / Q000378:metabolism*; D000818:Animals; D052160:Benzothiazoles; D002470:Cell Survival / Q000187:drug effects; D006108:Graphite / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D051379:Mice; D049329:Nanostructures / Q000737:chemistry; D010087:Oxides / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D016716:PC12 Cells; D010789:Phototherapy / Q000379:methods*; D051381:Rats; D013844:Thiazoles / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000682:Amyloid; D052160:Benzothiazoles; D010087:Oxides; D013844:Thiazoles; C009462:thioflavin T; D006108:Graphite