title: Multidrug resistant tuberculosis diagnosed by synovial fluid analysis.
abstract: Tuberculosis remains a major public health problem worldwide. HIV co-infection is contributing to an increased incidence of the disease, particularly that caused by multidrug resistant strains of Mycobacterium tuberculosis (MT). We describe an HIV-infected patient with pleural and lymph node tuberculosis diagnosed by pleural effusion characteristics and biopsy specimens, without MT identification, that further presented with knee-joint involvement. Arthrocentesis allowed MT isolation and drug susceptibility testing, resulting in a diagnosis of multidrug-resistant tuberculosis and an appropriate treatment regimen. MT identification and drug susceptibility tests are very important, especially for HIV co-infected patients.
authors.affiliation: Serviço de Pneumologia, Centro Hospitalar de São João, Porto, Portugal. mafalda vanzeller@hotmail.com
authors.forename: M
authors.initials: M
authors.lastname: van Zeller
authors.forename: R
authors.initials: R
authors.lastname: Monteiro
authors.forename: J
authors.initials: J
authors.lastname: Ramalho
authors.forename: I
authors.initials: I
authors.lastname: Almeida
authors.forename: R
authors.initials: R
authors.lastname: Duarte
mesh_terms: D000328:Adult; D006801:Humans; D008297:Male; D013582:Synovial Fluid / Q000382:microbiology*; D018088:Tuberculosis, Multidrug-Resistant / Q000175:diagnosis*