title: Orexins increase penicillin-induced epileptic activity.
abstract: Orexins have been implicated with physiological function including sleep-wake cycle, energy homeostasis, drinking behavior, analgesia, attention, learning and memory but their effects on excitability are controversial. We investigated the effects of intracortical injections of orexin A (100 pmol) and B (100 pmol) on the electrophysiological manifestation of epileptic seizures induced by cortical penicillin application in adult male rats. In comparison to saline, orexin A and B enhanced significantly the spike number, spike amplitude and spectral power values induced by cortical penicillin. Our findings indicates that orexins enhances the hyperexcitable and hypersyncronic cortical epileptic activity induced by focal application of penicillin-G.
authors.affiliation: Pamukkale University, Faculty of Medicine, Department of Pharmacology, Denizli, Turkey.
authors.forename: Selim
authors.initials: S
authors.lastname: Kortunay
authors.forename: Haydar Ali
authors.initials: HA
authors.lastname: Erken
authors.forename: Gülten
authors.initials: G
authors.lastname: Erken
authors.forename: Osman
authors.initials: O
authors.lastname: Genç
authors.forename: Melike
authors.initials: M
authors.lastname: Sahiner
authors.forename: Sebahat
authors.initials: S
authors.lastname: Turgut
authors.forename: Günfer
authors.initials: G
authors.lastname: Turgut
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002540:Cerebral Cortex / Q000187:drug effects* / Q000503:physiopathology; D004569:Electroencephalography; D004827:Epilepsy / Q000139:chemically induced / Q000503:physiopathology*; D057967:Infusions, Intraventricular; D047908:Intracellular Signaling Peptides and Proteins / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D009479:Neuropeptides / Q000008:administration & dosage / Q000009:adverse effects*; D018377:Neurotransmitter Agents / Q000008:administration & dosage / Q000009:adverse effects; D000068797:Orexins; D010400:Penicillin G / Q000008:administration & dosage / Q000009:adverse effects; D051381:Rats; D017208:Rats, Wistar
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D018377:Neurotransmitter Agents; D000068797:Orexins; D010400:Penicillin G