title: Effect of low dose dopamine on early graft function in living unrelated kidney donors.
abstract: OBJECTIVE
  To evaluate the effect of low-dose dopamine administration on the early function of the kidney in unrelated kidney donors after transplantation.
  
  
  METHODS
  In this double-blinded clinical trial, 60 adult kidney donors and 60 recipients, younger than 50 years old, were studied. Donors and recipients were randomly divided into two groups; group 1 received dopamine 3 µ/kg/min and group 2 received similar regimen of placebo. During the first 3 days postoperatively, serum levels of urea and creatinine as well as urine output and early kidney function were compared between two groups.
  
  
  RESULTS
  Serum levels of creatinine and urea and urine output during the first three days after the operation did not differ statistically significantly between two groups (P = .549, P = .306, and P = .375, respectively). Early kidney function was better significantly in group 1 (5.3 ± 3.2 versus 8.6 ± 8.0 hours; P = .048).
  
  
  CONCLUSIONS
  Premedication of the kidney transplant donors with low-dose dopamine accelerates early kidney function after transplantation, but has no effect on the hemodynamic status and serum levels of creatinine and urea in the donors.
authors.affiliation: Department of Anesthesiology, Imam Khomeini Hospital, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Hamzeh
authors.initials: H
authors.lastname: Hosseinzadeh
authors.forename: Samad E J
authors.initials: SE
authors.lastname: Golzari
authors.forename: Samad
authors.initials: S
authors.lastname: Golzari
authors.forename: Mohammad
authors.initials: M
authors.lastname: Abravesh
authors.forename: Ata
authors.initials: A
authors.lastname: Mahmoodpoor
authors.forename: Davood
authors.initials: D
authors.lastname: Aghamohammadi
authors.forename: Afshar
authors.initials: A
authors.lastname: Zomorrodi
authors.forename: Parisa
authors.initials: P
authors.lastname: Hosseinzadeh
mesh_terms: D000328:Adult; D016009:Chi-Square Distribution; D003404:Creatinine / Q000097:blood; D051799:Delayed Graft Function / Q000517:prevention & control*; D004231:Diuresis / Q000187:drug effects*; D004298:Dopamine / Q000008:administration & dosage* / Q000494:pharmacology; D004311:Double-Blind Method; D006801:Humans; D007677:Kidney Function Tests; D016030:Kidney Transplantation / Q000379:methods*; D008875:Middle Aged; D013566:Sympathomimetics / Q000008:administration & dosage* / Q000494:pharmacology; D013997:Time Factors; D014508:Urea / Q000097:blood; D014556:Urine; D055815:Young Adult
chemical_list: D013566:Sympathomimetics; D014508:Urea; D003404:Creatinine; D004298:Dopamine