title: Antigen-specific T cells and cytokines detection as useful tool for understanding immunity against zoonotic infections.
abstract: Zoonoses include a broad range of diseases, that are becoming of great interest, due to the climate changing, that cause the adaptation of vectors to new niches and environments. Host immune responses play a crucial role in determining the outcome of infections, as documented by expansion of antigen-specific T cells during several zoonotic infections. Thus, understanding of the contribution of antigen-specific T-cell subsets in the host immune response is a powerful tool to evaluate the different immunological mechanisms involved in zoonotic infections and for the development of effective vaccines. In this paper we discuss the role of T cells in some eukaryotic and prokaryotic infectious models.
authors.affiliation: Dipartimento di Biopatologia e Biotecnologie Mediche e Forensi, Università di Palermo, Corso Tukory 211, 90134 Palermo, Italy.
authors.forename: Annalisa
authors.initials: A
authors.lastname: Agnone
authors.forename: Alessandra
authors.initials: A
authors.lastname: Torina
authors.forename: Gesualdo
authors.initials: G
authors.lastname: Vesco
authors.forename: Sara
authors.initials: S
authors.lastname: Villari
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Vitale
authors.forename: Santo
authors.initials: S
authors.lastname: Caracappa
authors.forename: Marco Pio
authors.initials: MP
authors.lastname: La Manna
authors.forename: Francesco
authors.initials: F
authors.lastname: Dieli
authors.forename: Guido
authors.initials: G
authors.lastname: Sireci
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D000941:Antigens / Q000276:immunology*; D001419:Bacteria / Q000276:immunology; D016207:Cytokines / Q000032:analysis* / Q000096:biosynthesis / Q000276:immunology; D006790:Host-Parasite Interactions; D054884:Host-Pathogen Interactions; D006801:Humans; D007113:Immunity, Innate; D009348:Nematoda / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D058408:Th1-Th2 Balance; D014612:Vaccines / Q000276:immunology; D015047:Zoonoses / Q000382:microbiology / Q000469:parasitology
chemical_list: D000941:Antigens; D016207:Cytokines; D014612:Vaccines