title: Metabolic disorders increase the risk to incident cardiovascular disease in middle-aged and elderly Chinese.
abstract: OBJECTIVE
  The association of metabolic syndrome (MetS) with cardiovascular diseases (CVD) has not been adequately explored in middle-aged and elderly Chinese. This study aimed to investigate MetS' prevalence and its impact on the CVD incidence in this specific population group.
  
  
  METHODS
  A data set of a community-based prospective cohort study was analyzed. A total of 2300 subjects aged 40-94 years were followed up for the CVD events. MetS defined according to the JCDCG criteria was assessed at baseline, and the middle-aged and elderly groups were classified by the WHO definition.
  
  
  RESULTS
  As compared with the middle-aged group, the prevalence of MetS increased by 0.6 times (34.6% vs. 21.3%) and the incidence density of CVD increased by 4.9 times in the elderly group (52.3/1000 person-year vs. 8.9/1000 person-year). Furthermore, the multivariate Cox regression revealed that the risk to CVD incidence was independently related to increased waist circumference in the middle-aged group (HR=2.23, P<0.01) and to elevated blood glucose in the elderly group (HR=1.39, P<0.01).
  
  
  CONCLUSIONS
  MetS was highly prevalent in middle-aged and elderly Chinese. MetS significantly increased the risk to CVD incidence in the elderly. All individuals with metabolic disorders should receive active clinical care to reduce the incidence of CVD.
authors.affiliation: Department of Endocrinology and Metabolism, Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, China.
authors.forename: Ming Liang
authors.initials: ML
authors.lastname: Zhang
authors.forename: Xu Hong
authors.initials: XH
authors.lastname: Hou
authors.forename: Yun Xia
authors.initials: YX
authors.lastname: Zhu
authors.forename: Jun Xi
authors.initials: JX
authors.lastname: Lu
authors.forename: Liang Pu
authors.initials: LP
authors.lastname: Peng
authors.forename: Hui Lin
authors.initials: HL
authors.lastname: Gu
authors.forename: Wei Ping
authors.initials: WP
authors.lastname: Jia
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000209:etiology; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000453:epidemiology*; D008875:Middle Aged; D015995:Prevalence; D016016:Proportional Hazards Models