title: Canine periodontal disease control using a clindamycin hydrochloride gel.
abstract: Stabilizing or reducing periodontal pocket depth can have a positive influence on the retention of teeth in dogs. A topical 2% clindamycin hydrochloride gel (CHgel) was evaluated for the treatment of periodontal disease in dogs. The CHgel formulation provides for the sustained erosion of the matrix, but also flows into the periodontal pocket as a viscous liquid, and then rapidly forms a gel that has mucoadhesive properties and also may function as a physical barrier to the introduction of bacteria. A professional teeth cleaning procedure including scaling and root planing was done in dogs with one group receiving CHgel following treatment. Periodontal health was determined before and after the procedure including measurement of periodontal pocket depth, gingival index, gingival bleeding sites, and number of suppurating sites. There was a statistically significant decrease in periodontal pocket depth (19%), gingival index (16%), and the number of bleeding sites (64%) at 90-days in dogs receiving CHgel. Additionally, the number of suppurating sites was lower (93%) at 90-days for the group receiving CHgel. The addition of CHgel effectively controlled the bacterial burden (e.g, Fusobacterium nucleatum) at both day 14 and 90. Gingival cells in culture were shown to rapidly incorporate clindamycin and attain saturation in approximately 20-minutes. In summary, a professional teeth cleaning procedure including root planning and the addition of CHgel improves the gingival index and reduces periodontal pocket depth.
authors.affiliation: Division of Pharmaceutical Science, School of Pharmacy, University of Missouri-Kansas City, MO, USA. johnstont@umkc.edu
authors.forename: Thomas P
authors.initials: TP
authors.lastname: Johnston
authors.forename: Pravakar
authors.initials: P
authors.lastname: Mondal
authors.forename: Dhananjay
authors.initials: D
authors.lastname: Pal
authors.forename: Scott
authors.initials: S
authors.lastname: MacGee
authors.forename: Arnold J
authors.initials: AJ
authors.lastname: Stromberg
authors.forename: Hemant
authors.initials: H
authors.lastname: Alur
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002626:Chemistry, Pharmaceutical; D002981:Clindamycin / Q000008:administration & dosage*; D004283:Dog Diseases / Q000517:prevention & control*; D004285:Dogs; D005260:Female; D005782:Gels; D008297:Male; D009910:Oral Hygiene / Q000662:veterinary; D010510:Periodontal Diseases / Q000517:prevention & control*; D014100:Toothpastes / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D005782:Gels; D014100:Toothpastes; D002981:Clindamycin