title: Amphiphilic cylindrical copolypeptide brushes as potential nanocarriers for the simultaneous encapsulation of hydrophobic and cationic drugs.
abstract: Cylindrical copolypeptide brushes PLLF-g-(PLF-b-PLG) with poly(L-lysine-co-L-phenylalanine) (PLLF) as the backbone and poly(L-phenylalanine)-b-poly(L-glutamic acid) (PLF-b-PLG) as the side chains have been synthesized and evaluated as drug delivery carriers. The synthesized copolypeptide brushes were characterized by (1)H NMR, gel permeation chromatography (GPC), and transmission electron microscopy (TEM). In aqueous solution, the copolypeptide brushes adopt cylindrical morphologies and resemble unimolecular polymeric micelles with a hydrophobic poly(L-phenylalanine) core and a hydrophilic poly(L-glutamate) shell. An encapsulation study demonstrated that these water soluble, biodegradable copolypeptide brushes encapsulate hydrophobic compounds and cationic hydrophilic guest molecules simultaneously. Furthermore, the encapsulated cationic model compounds exhibit a pH-responsive releasing property.
authors.affiliation: Medical College, Shantou University, Shantou, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Zeng
authors.forename: Jinhu
authors.initials: J
authors.lastname: Li
authors.forename: Jinhong
authors.initials: J
authors.lastname: Zheng
authors.forename: Ying
authors.initials: Y
authors.lastname: Pan
authors.forename: Jinzhi
authors.initials: J
authors.lastname: Wang
authors.forename: Lumian
authors.initials: L
authors.lastname: Zhang
authors.forename: Xiaoying
authors.initials: X
authors.lastname: He
authors.forename: Daojun
authors.initials: D
authors.lastname: Liu
mesh_terms: D000838:Anions; D002412:Cations; D002850:Chromatography, Gel; D004337:Drug Carriers / Q000138:chemical synthesis*; D004339:Drug Compounding; D057927:Hydrophobic and Hydrophilic Interactions; D009682:Magnetic Resonance Spectroscopy; D008823:Micelles; D046529:Microscopy, Electron, Transmission; D049329:Nanostructures / Q000737:chemistry / Q000648:ultrastructure; D010455:Peptides / Q000138:chemical synthesis*; D055553:Prescription Drugs / Q000737:chemistry; D012996:Solutions; D013501:Surface-Active Agents / Q000138:chemical synthesis*
chemical_list: D000838:Anions; D002412:Cations; D004337:Drug Carriers; D008823:Micelles; D010455:Peptides; D055553:Prescription Drugs; D012996:Solutions; D013501:Surface-Active Agents