title: Immunosuppressive decalin derivatives from red yeast rice.
abstract: Five new decalin derivatives (1-5), together with two known compounds (6 and 7), were isolated from the ethyl acetate extract of red yeast rice. Their structures were elucidated by means of NMR and mass spectroscopic analyses. Monascusic lactone A (1) is the first reported naturally occurring decalin derivative possessing a spiro lactone at the C-1 position. The immunosuppressive effects of all these isolates (1-7) on human T cell proliferation were investigated, and all, especially monascusic acids B (2), C (3), D (4), and A (6) and heptaketide (7), suppressed human T cell proliferation in a dose-dependent manner from 10 to 100 μM. This is the first report on the immunosuppressive activity of decalin derivatives.
authors.affiliation: School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong, People's Republic of China.
authors.forename: Lin
authors.initials: L
authors.lastname: Zhu
authors.forename: Jing-Guang
authors.initials: JG
authors.lastname: Lu
authors.forename: Ting
authors.initials: T
authors.lastname: Li
authors.forename: Guo-Yuan
authors.initials: GY
authors.lastname: Zhu
authors.forename: Quan-Bin
authors.initials: QB
authors.lastname: Han
authors.forename: Wen-Luan
authors.initials: WL
authors.lastname: Hsiao
authors.forename: Liang
authors.initials: L
authors.lastname: Liu
authors.forename: Zhi-Hong
authors.initials: ZH
authors.lastname: Jiang
mesh_terms: D001688:Biological Products / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000494:pharmacology*; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry / Q000494:pharmacology*; D019906:Nuclear Magnetic Resonance, Biomolecular; D013329:Structure-Activity Relationship; D013601:T-Lymphocytes / Q000187:drug effects
chemical_list: D001688:Biological Products; D007166:Immunosuppressive Agents; D009281:Naphthalenes; C573517:monascusic lactone A; C117343:red yeast rice; C007229:decalin