title: Synthetic in vitro transcription circuits.
abstract: With the help of only two enzymes--an RNA polymerase and a ribonuclease--reduced versions of transcriptional regulatory circuits can be implemented in vitro. These circuits enable the emulation of naturally occurring biochemical networks, the exploration of biological circuit design principles and the biochemical implementation of powerful computational models.
authors.affiliation: Lehrstuhl für Bioelektronik, Physik-Department and ZNN/WSI, Technische Universität München, Garching, Germany.
authors.forename: Maximilian
authors.initials: M
authors.lastname: Weitz
authors.forename: Friedrich C
authors.initials: FC
authors.lastname: Simmel
mesh_terms: D012321:DNA-Directed RNA Polymerases / Q000235:genetics / Q000378:metabolism*; D008957:Models, Genetic; D012260:Ribonucleases / Q000235:genetics / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D012321:DNA-Directed RNA Polymerases; D012260:Ribonucleases