title: Oxime esters of 2,6-diazaanthracene-9,10-dione and 4,5-diazafluoren-9-one as photo-induced DNA-cleaving agents.
abstract: Two series of oxime esters containing the 2,6-diazaanthracene-9,10-dione bis-(O-benzoyloxime) and 4,5-diazafluoren-9-one O-9-benzoyloxime moieties have been synthesized and tested as photo-induced DNA cleaving agents. All these compounds were found to cleave DNA upon irradiation with 312 nm UV light. The structure-activity relationship of these molecules for DNA cleavage was established. A plausible reaction mechanism is also proposed.
authors.affiliation: Department of Chemistry, Fu Jen Catholic University, New Taipei 24205, Taiwan. a22022148@yahoo.com.tw
authors.forename: Shang-Shing P
authors.initials: SS
authors.lastname: Chou
authors.forename: Jui-Chi
authors.initials: JC
authors.lastname: Juan
authors.forename: Shwu-Chen
authors.initials: SC
authors.lastname: Tsay
authors.forename: Kuei Pin
authors.initials: KP
authors.lastname: Huang
authors.forename: Jih Ru
authors.initials: JR
authors.lastname: Hwu
mesh_terms: D000873:Anthracenes / Q000737:chemistry*; D053837:DNA Cleavage / Q000528:radiation effects*; D005449:Fluorenes; D008027:Light; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: C531330:4,5-diazafluoren-9-one; D000873:Anthracenes; D005449:Fluorenes; D011725:Pyridines; C034020:anthracene