title: The cerebrospinal fluid: regulator of neurogenesis, behavior, and beyond.
abstract: The cerebrospinal fluid (CSF) has attracted renewed interest as an active signaling milieu that regulates brain development, homeostasis, and disease. Advances in proteomics research have enabled an improved characterization of the CSF from development through adulthood, and key neurogenic signaling pathways that are transmitted via the CSF are now being elucidated. Due to its immediate contact with neural stem cells in the developing and adult brain, the CSF's ability to swiftly distribute signals across vast distances in the central nervous system is opening avenues to novel and exciting therapeutic approaches. In this review, we will discuss the development of the choroid plexus-CSF system, and review the current literature on how the CSF actively regulates mammalian brain development, behavior, and responses to traumatic brain injury.
authors.affiliation: Department of Physical Medicine and Rehabilitation, VA Greater Los Angeles Healthcare System, 11301 Wilshire Blvd, Los Angeles, CA 90073, USA. mauro.zappaterra@ucla.edu
authors.forename: Mauro W
authors.initials: MW
authors.lastname: Zappaterra
authors.forename: Maria K
authors.initials: MK
authors.lastname: Lehtinen
mesh_terms: D000328:Adult; D001519:Behavior; D001921:Brain / Q000378:metabolism*; D001930:Brain Injuries / Q000134:cerebrospinal fluid*; D002555:Cerebrospinal Fluid / Q000378:metabolism*; D002831:Choroid Plexus / Q000098:blood supply / Q000378:metabolism*; D006801:Humans; D055495:Neurogenesis