title: [Genetic performance criteria for valproate in patients with epilepsy].
abstract: We found a clear correlation between the presence of the CC genotype and genotype combination CC and CT P-glycoproteins rs1045642 and rs1128503 with farmakorezystentnistyu data of patients with valproate (P < 0,01). Also, based on studies demonstrated that the presence of polymorphism TT P-glycoproteins rs1045642 is a positive criterion of forecast performance valproate in a particular patient with epilepsy. We use the definition of P-glycoproteins SNPs rs1045642 and rs1128503 to accelerate the selection of adequate antiepileptic that reduces the selection of adequate treatment tactics in a particular patient. This in turn will prevent the development epileptohenezu that increase the likelihood of full kurabelnosti patient.
authors.forename: M M
authors.initials: MM
authors.lastname: Oros
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000737:chemistry / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004351:Drug Resistance / Q000235:genetics*; D004827:Epilepsy / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D010597:Pharmacogenetics / Q000379:methods*; D020641:Polymorphism, Single Nucleotide; D016896:Treatment Outcome; D014635:Valproic Acid / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000927:Anticonvulsants; D014635:Valproic Acid