title: Synthesis of highly functionalized β-aminocyclopentanecarboxylate stereoisomers by reductive ring opening reaction of isoxazolines.
abstract: A rapid and simple procedure was devised for the synthesis of multifunctionalized cyclic β-amino esters and γ-amino alcohols via the 1,3-dipolar cycloaddition of nitrile oxides to β-aminocyclopentenecarboxylates. The opening of the isoxazoline reductive ring to the corresponding highly functionalized 2-aminocyclopentanecarboxylates occurred stereoselectively with good yields.
authors.affiliation: Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary.
authors.forename: Melinda
authors.initials: M
authors.lastname: Nonn
authors.forename: Loránd
authors.initials: L
authors.lastname: Kiss
authors.forename: Reijo
authors.initials: R
authors.lastname: Sillanpää
authors.forename: Ferenc
authors.initials: F
authors.lastname: Fülöp