title: Multifunctional stable fluorescent magnetic nanoparticles.
abstract: Because of their multifunctionality and unique magnetic properties, superparamagnetic iron oxide nanoparticles (SPIONs) have been recognized as very promising materials for various biomedical applications. The main difficulty with the use of SPIONs as multimodal bioimaging agents is their lack of fluorescence. Since cells can act as extremely efficient filters for the elution of surface-bound fluorescent tags with nanoparticles, the surface loaded fluorescence dyes significantly decay after a short period of time. Here, for the first time, we introduce novel, engineered multimodal SPIONs with a permanent fluorescence capability, the study of which can lead to a deeper understanding of biological processes at the biomolecular level, greatly influencing molecular diagnostics, imaging and therapeutic applications.
authors.affiliation: National Cell Bank, Pasteur Institute of Iran, Tehran, Iran. mahmoudi@biospion.com
authors.forename: Morteza
authors.initials: M
authors.lastname: Mahmoudi
authors.forename: Mohammad A
authors.initials: MA
authors.lastname: Shokrgozar
mesh_terms: D005290:Ferric Compounds / Q000737:chemistry*; D005456:Fluorescent Dyes / Q000737:chemistry*; D006046:Gold / Q000737:chemistry; D059346:Magnets / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D053758:Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry
chemical_list: D005290:Ferric Compounds; D005456:Fluorescent Dyes; D011108:Polymers; C000499:ferric oxide; D006046:Gold