title: Association of the intronic polymorphism rs891512 (G24943A) of the endothelial nitric oxide synthase gene with hypertension in Chilean type 2 diabetes patients.
abstract: We investigated two single nucleotide polymorphisms of the NOS3 gene in type 2 diabetic patients (n=93) and healthy non-diabetic controls (n=76) and their relationship with smoking habits, body mass index, hypertension and dyslipidemia. Results showed that eNOS polymorphism rs891512 (G24943A) is associated with hypertension in Chilean individuals (p<0.05).
authors.affiliation: Department of Biochemistry, Faculty of Chemical and Pharmaceutical Sciences, University of Chile, V. Mackenna 20, Providencia, Santiago, Chile. dseelen@ciq.uchile.cl
authors.forename: D
authors.initials: D
authors.lastname: Seelenfreund
authors.forename: S R
authors.initials: SR
authors.lastname: Lobos
authors.forename: A
authors.initials: A
authors.lastname: Quesada
authors.forename: J M
authors.initials: JM
authors.lastname: Saavedra
authors.forename: C
authors.initials: C
authors.lastname: Wolff
authors.forename: G
authors.initials: G
authors.lastname: López-Stewart
authors.forename: A V
authors.initials: AV
authors.lastname: Araya
authors.forename: P
authors.initials: P
authors.lastname: Durruty
mesh_terms: D015992:Body Mass Index; D002677:Chile; D003924:Diabetes Mellitus, Type 2 / Q000201:enzymology / Q000235:genetics*; D006801:Humans; D006973:Hypertension / Q000201:enzymology* / Q000235:genetics; D052250:Nitric Oxide Synthase Type III / Q000235:genetics / Q000378:metabolism*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012907:Smoking
chemical_list: C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III