title: Evaluation of rib microstructure in Wistar rats using SR-μCT after radiation therapy simulation for breast cancer.
abstract: A better understanding of biological interactions that occur after exposure to photon radiation is needed in order to optimize therapeutic regimens and facilitate development and strategies that decrease radiation-induced side effects in humans. In this work, ribs of Wistar rat submitted to radiotherapy simulation were imaged using synchrotron radiation computed microtomography at Elettra Synchrotron Laboratory in Trieste, Italy. Histomorphometric parameters were calculated directly from the 3D microtomographic images and showed significant differences between irradiated and non-irradiated groups.
authors.affiliation: Nuclear Instrumentation Laboratory/COPPE/UFRJ, P.O. Box 68509, 21945-970 Rio de Janeiro, Brazil.
authors.forename: Liebert P
authors.initials: LP
authors.lastname: Nogueira
authors.forename: André P
authors.initials: AP
authors.lastname: de Almeida
authors.forename: Delson
authors.initials: D
authors.lastname: Braz
authors.forename: Cherley B
authors.initials: CB
authors.lastname: Andrade
authors.forename: Camila
authors.initials: C
authors.lastname: Salata
authors.forename: Giuliana
authors.initials: G
authors.lastname: Tromba
authors.forename: Carlos E
authors.initials: CE
authors.lastname: de Almeida
authors.forename: Regina C
authors.initials: RC
authors.lastname: Barroso
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D004195:Disease Models, Animal; D005260:Female; D051381:Rats; D017208:Rats, Wistar; D012272:Ribs / Q000473:pathology*; D017356:Synchrotrons; D014057:Tomography, X-Ray Computed / Q000379:methods*