title: Abortive replication of influenza virus in mouse dendritic cells.
abstract: The interaction between influenza virus and dendritic cells (DCs) remains poorly defined and controversial. Here we show that influenza virus replication in mouse bone marrow-derived DCs is abortive, despite viral genome transcription and replication occurring for each gene segment and viral hemagglutinin and nucleoprotein, at least, being produced. Electron microscopy reveals that virus assembly, rather than release of virus from the cell surface, is defective.
authors.affiliation: Department of Microbiology and Immunology, University of Melbourne, Parkville, Victoria, Australia.
authors.forename: Lisa J
authors.initials: LJ
authors.lastname: Ioannidis
authors.forename: Erin E
authors.initials: EE
authors.lastname: Verity
authors.forename: Simon
authors.initials: S
authors.lastname: Crawford
authors.forename: Steven P
authors.initials: SP
authors.lastname: Rockman
authors.forename: Lorena E
authors.initials: LE
authors.lastname: Brown
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D003713:Dendritic Cells / Q000821:virology*; D004285:Dogs; D019267:Hemagglutinin Glycoproteins, Influenza Virus / Q000235:genetics / Q000378:metabolism; D006801:Humans; D009980:Influenza A virus / Q000235:genetics / Q000502:physiology*; D007251:Influenza, Human / Q000276:immunology / Q000821:virology*; D051379:Mice; D008810:Mice, Inbred C57BL; D057074:Virus Release; D014779:Virus Replication
chemical_list: D019267:Hemagglutinin Glycoproteins, Influenza Virus