title: Carbon-boron bond cross-coupling reaction catalyzed by -PPh(2) containing palladium-indolylphosphine complexes.
abstract: This study describes the application of indolylphosphine ligands with a diphenylphosphino moiety to the palladium-catalyzed borylation of aryl chlorides. The combination of palladium metal precursor with PPh(2)-Andole-phos, which comprises an inexpensive -PPh(2) group, provides highly effective catalysts for the borylation of aryl chlorides. A range of functional groups such as -CN, -NO(2), -CHO, -COMe, -COOMe, and -CF(3) was compatible, and the catalyst loading down to 0.025 mol % of Pd can be achieved. The Pd/PPh(2)-Andole-phos system is able to catalyze both borylation reaction and Suzuki-Miyaura coupling reaction in a one-pot sequential manner for the direct synthesis of biaryl compounds in excellent yields.
authors.affiliation: State Key Laboratory of Chirosciences and Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Kowloon, Hong Kong.
authors.forename: Wing Kin
authors.initials: WK
authors.lastname: Chow
authors.forename: On Ying
authors.initials: OY
authors.lastname: Yuen
authors.forename: Chau Ming
authors.initials: CM
authors.lastname: So
authors.forename: Wing Tak
authors.initials: WT
authors.lastname: Wong
authors.forename: Fuk Yee
authors.initials: FY
authors.lastname: Kwong
mesh_terms: D001895:Boron / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D002384:Catalysis; D003432:Cross-Linking Reagents / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D009943:Organophosphorus Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: D003432:Cross-Linking Reagents; D009942:Organometallic Compounds; D009943:Organophosphorus Compounds; D010165:Palladium; D002244:Carbon; D001895:Boron