title: [Expression and clinical significance of cyclin E2 in nasopharyngeal carcinoma].
abstract: OBJECTIVE
  To explore the expressions of Cyclin E2 in nasopharyngeal carcinoma (NPC) and clinic opathological parameters,  and to investigate the role of Cyclin E2 in oncogenesis,  progress,  invasion and metastasis of NPC.
  
  
  METHODS
  Sixty patients with NPC and twenty-one noncancerous nasopharyngeal epithelial samples were retrospectively studied from year 2000 to 2006,  The protein and mRNA expressions of Cyclin E2 was detected by immunohistochemical staining and RT-PCR.
  
  
  RESULTS
  The protein expressions rates of Cyclin E2 were 75% and 9.5% in nasopharyngeal samples and noncancerous nasopharyngeal epithelial samples,  It was significantly higher in NPC than in normal controls (P<0.01). Furthermore,  the protein expression was significantly higher in NPC patients with clinical staging and cervical lymph node or poor prognosis than in NPC patients without(P<0.01). The expression in NPC was not correlated with gender or age (P>0.05).   The mRNA expression of Cyclin E2 was significantly higher in NPC than in normal controls (P<0.01).
  
  
  CONCLUSIONS
  These findings demonstrate that Cyclin E2 may play important roles in the invasion,  metastasis,  and poor prognosis of NPC.
authors.affiliation: Department of Otolaryngology, Chinese PLA 152 Hospital, Pingdingshan, China.
authors.forename: Guang-hui
authors.initials: GH
authors.lastname: Zhao
authors.forename: Guo-qi
authors.initials: GQ
authors.lastname: Xie
authors.forename: Ying-ye
authors.initials: YY
authors.lastname: Miao
mesh_terms: D002277:Carcinoma; D016213:Cyclins / Q000235:genetics* / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077274:Nasopharyngeal Carcinoma; D009303:Nasopharyngeal Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism
chemical_list: C503688:CCNE2 protein, human; D016213:Cyclins; D012333:RNA, Messenger