title: Anti-inflammatory effect of three iridoids in human neutrophils.
abstract: To verify the anti-inflammatory potency of iridoids, three iridoids (two natural, loganic acid: LA; geniposide: GE; and an artefact, 7(S)-n-butyl morroniside: BM) were investigated in vitro on the inhibition of superoxide generation in human neutrophils. All compounds showed inhibitory effect on fMLP-induced superoxide generation in a concentration-dependent manner with the following order: BM>LA>GE. BM exhibits potent inhibitory activity on superoxide anion induced by PMA, while LA and GE showed weak effect. When AA was used as stimulus, the generation of superoxide anion was suppressed by BM in a concentration-dependent manner. LA and GE exhibit both sides effect on superoxide generation.
authors.affiliation: College of Life Science and Technology, Beijing University of Chemical Technology, Beijing 100029, PR China.
authors.forename: Shihu
authors.initials: S
authors.lastname: Wei
authors.forename: Haidong
authors.initials: H
authors.lastname: Chi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kodama
authors.forename: Guang
authors.initials: G
authors.lastname: Chen
mesh_terms: D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D016718:Arachidonic Acid / Q000494:pharmacology; D006801:Humans; D039823:Iridoids / Q000494:pharmacology*; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D039823:Iridoids; D013481:Superoxides; C007835:geniposide; C002947:loganic acid; D016718:Arachidonic Acid; D009240:N-Formylmethionine Leucyl-Phenylalanine