title: The association between early arterial oxygenation and mortality in ventilated patients with acute ischaemic stroke.
abstract: BACKGROUND
  There are conflicting data that suggest that hyperoxia may be associated with either worse or better outcomes in patients suffering a stroke.
  
  
  OBJECTIVE
  To investigate the association between PaO(2) in the first 24 hours in the intensive care unit and mortality among ventilated patients with acute ischaemic stroke.
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  Data were extracted from the Australian and New Zealand Intensive Care Society Adult Patient Database.
  
  
  METHODS
  Adults ventilated for ischaemic stroke in 129 ICUs in Australia and New Zealand, 2000-2009.
  
  
  METHODS
  The primary outcome was the odds ratio for in hospital mortality associated with "worst" PaO(2) considered as a categorical variable, with data divided into deciles and compared with the mortality of the 10th decile. For patients on an FiO(2) of _50% at any time in the first 24 hours, "worst" PaO(2) was defined as the PaO(2) associated with the highest alveolar-arterial (A-a) gradient. For patients on an FiO(2) of <50%, it was defined as the lowest PaO(2). Secondary outcomes were ICU and hospital length of stay and the proportion of patients in each decile discharged home.
  
  
  RESULTS
  Of the 2643 patients eligible for study inclusion, 1507 (57%) died in hospital. The median "worst" PaO(2) was 117mmHg (interquartile range, 87-196mmHg). There was no association between worst PaO(2) and mortality, length of stay or likelihood of discharge home.
  
  
  CONCLUSIONS
  We found no association between worst arterial oxygen tension in the first 24 hours in ICU and outcome in ventilated patients with ischaemic stroke.
authors.affiliation: Wellington Regional Hospital, Capital and Coast District Health Board, Wellington, New Zealand. Paul.Young@ccdhb.org.nz
authors.forename: Paul
authors.initials: P
authors.lastname: Young
authors.forename: Richard
authors.initials: R
authors.lastname: Beasley
authors.forename: Michael
authors.initials: M
authors.lastname: Bailey
authors.forename: Rinaldo
authors.initials: R
authors.lastname: Bellomo
authors.forename: Glenn M
authors.initials: GM
authors.lastname: Eastwood
authors.forename: Alistair
authors.initials: A
authors.lastname: Nichol
authors.forename: David V
authors.initials: DV
authors.lastname: Pilcher
authors.forename: Nor'azim M
authors.initials: NM
authors.lastname: Yunos
authors.forename: Moritoki
authors.initials: M
authors.lastname: Egi
authors.forename: Graeme K
authors.initials: GK
authors.lastname: Hart
authors.forename: Michael C
authors.initials: MC
authors.lastname: Reade
authors.forename: D James
authors.initials: DJ
authors.lastname: Cooper
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001315:Australia / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D006801:Humans; D018496:Hyperoxia / Q000097:blood; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D009520:New Zealand / Q000453:epidemiology; D010100:Oxygen / Q000008:administration & dosage / Q000097:blood*; D010313:Partial Pressure; D012121:Respiration, Artificial; D012189:Retrospective Studies; D020521:Stroke / Q000097:blood* / Q000401:mortality / Q000628:therapy*
chemical_list: D010100:Oxygen