title: Association between gastric cancer and -1993 polymorphism of TBX21 gene.
abstract: OBJECTIVE
  To investigate the association between the polymorphism of TBX21 gene and the risk of gastric cancer in a Chinese population.
  
  
  METHODS
  The -1993 polymorphism located in TBX21 gene promoter region was identified by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. The risk between TBX21 gene genotype and gastric cancer was determined by multivariate logistic regression analysis in 220 gastric cancer patients and 262 cancer-free controls matched by age, sex and ethnicity.
  
  
  RESULTS
  Compared with the TBX21 -1993TT genotype, the -1993CC genotype exhibited a significantly elevated risk for gastric cancer [Odds ratio (OR) = 3.42, 95% confidence interval (CI): 1.41-8.31]. The relationship between the -1993 polymorphic genotype and the invasive status such as lymph node and distant metastasis was found among the gastric cancer patients (OR = 4.02, 95% CI: 1.87-8.66; OR = 7.02, 95% CI: 3.44-14.34, respectively).
  
  
  CONCLUSIONS
  TBX21 -1993 polymorphism might contribute to the risk of gastric cancer, especially to the distant metastasis.
authors.affiliation: Department of Epidemiology and Health Statistics, School of Public Health and Family Medicine, Capital Medical University, Beijing 100069, China.
authors.forename: Le-Hui
authors.initials: LH
authors.lastname: Zhang
authors.forename: Qin
authors.initials: Q
authors.lastname: Li
authors.forename: Peng
authors.initials: P
authors.lastname: Li
authors.forename: Sheng-Tao
authors.initials: ST
authors.lastname: Zhu
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Hong-Li
authors.initials: HL
authors.lastname: Yang
authors.forename: Chang-Qing
authors.initials: CQ
authors.lastname: Xu
authors.forename: Xiu-Hua
authors.initials: XH
authors.lastname: Guo
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology; D020825:T-Box Domain Proteins / Q000235:genetics*; D000098815:T-bet Transcription Factor
chemical_list: D020825:T-Box Domain Proteins; D000098815:T-bet Transcription Factor