title: Intrapulmonary neurofibroma independent of neurofibromatosis type 1.
abstract: Intrapulmonary neurofibromas without neurofibromatosis type 1 are rare-so rare that only 11 cases have been reported previously. This case report describes a 37-year-old woman who was otherwise healthy. Chest radiography and computed tomography showed a solitary nodule, 20 mm diameter, in the left lung. The tumor was removed and examined. It was not encapsulated but was covered with an intact bronchial mucosa and lacked a clear partition into two areas of Antoni A (a palisading cellular component) and Antoni B (a loose myxoid component). Tumor cells were strongly positive for neuron-specific enolase and S-100 protein. These data characterized the tumor as a rare benign neurofibroma. The patient shows no sign of recurrence after 12 months of follow-up. We reviewed and characterized surgically resected cases of intrapulmonary neurofibroma without neurofibromatosis type 1 especially in comparison with cases of endotracheobronchial neurofibroma.
authors.affiliation: Department of General Thoracic Surgery, Osaka Kosei-Nenkin Hospital, Fukushima-ku, Osaka, Japan. teruteruah@m4.dion.ne.jp
authors.forename: Teruo
authors.initials: T
authors.lastname: Iwasaki
authors.forename: Mitsunori
authors.initials: M
authors.lastname: Ohta
authors.forename: Akira
authors.initials: A
authors.lastname: Okimura
authors.forename: Kunimitsu
authors.initials: K
authors.lastname: Kawahara
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D002675:Child, Preschool; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009455:Neurofibroma / Q000737:chemistry / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D009456:Neurofibromatosis 1 / Q000175:diagnosis* / Q000473:pathology; D011013:Pneumonectomy / Q000379:methods; D011237:Predictive Value of Tests; D019275:Radiopharmaceuticals; D020775:Thoracic Surgery, Video-Assisted; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18