title: Cardiac hormones are c-Jun-N-terminal kinase 2-inhibiting peptides.
abstract: BACKGROUND
  Four cardiac peptide hormones, namely vessel dilator, long-acting natriuretic peptide (LANP), kaliuretic peptide, and atrial natriuretic peptide (ANP) have anticancer effects.
  
  
  METHODS
  The effects of these four cardiac hormones on human c-Jun-N-terminal kinase 2 (JNK2) were examined in human small cell lung cancer and human prostate cancer cells.
  
  
  RESULTS
  Vessel dilator, LANP, kaliuretic peptide and ANP maximally reduced expression of JNK2 by 89%, 56%, 45%, and 28%, respectively (each at p<0.0001) in human small cell lung cancer cells. In human prostate adenocarcinoma cells, JNK2 was maximally decreased 76%, 56%, 45%, (each at p<0.0001), and 28% (p<0.01) secondary to vessel dilator, LANP, kaliuretic peptide and ANP, respectively.
  
  
  CONCLUSIONS
  These results indicate that four cardiac hormones are significant inhibitors (by up to 89%) of JNK2 in human small cell lung cancer cells and up to 76% in human prostate adenocarcinoma cells as part of their anticancer mechanism(s) of action.
authors.affiliation: Department of Medicine, James A. Haley VA Medical Center, University of South Florida for Health Sciences, Tampa, FL, USA.
authors.forename: Meghan L
authors.initials: ML
authors.lastname: Lane
authors.forename: Omar
authors.initials: O
authors.lastname: Santana
authors.forename: Chelsea D
authors.initials: CD
authors.lastname: Frost
authors.forename: Jennifer
authors.initials: J
authors.lastname: Nguyen
authors.forename: Jennifer
authors.initials: J
authors.lastname: Guerrero
authors.forename: William P
authors.initials: WP
authors.lastname: Skelton
authors.forename: Michelle
authors.initials: M
authors.lastname: Skelton
authors.forename: David L
authors.initials: DL
authors.lastname: Vesely
mesh_terms: D009320:Atrial Natriuretic Factor / Q000502:physiology*; D002289:Carcinoma, Non-Small-Cell Lung / Q000201:enzymology / Q000473:pathology; D045744:Cell Line, Tumor; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D008175:Lung Neoplasms / Q000201:enzymology / Q000473:pathology; D048056:Mitogen-Activated Protein Kinase 9 / Q000037:antagonists & inhibitors*
chemical_list: D009320:Atrial Natriuretic Factor; D048056:Mitogen-Activated Protein Kinase 9