title: Fabrication and characterization of a solid-state nanopore with self-aligned carbon nanoelectrodes for molecular detection.
abstract: Stochastic  molecular  sensors based on resistive pulse nanopore modalities are envisioned as facile DNA sequencers. However, recent advances in nanotechnology fabrication have highlighted promising alternative detection mechanisms with higher sensitivity and potential single-base resolution. In this paper we present the novel self-aligned fabrication of a solid-state nanopore device with integrated transverse graphene-like carbon nanoelectrodes for polyelectrolyte molecular detection. The electrochemical transduction mechanism is characterized and found to result primarily from thermionic emission between the two transverse electrodes. Response of the nanopore to Lambda dsDNA and short (16-mer) ssDNA is demonstrated and distinguished.
authors.affiliation: MicroInstruments & Systems Laboratory, University of Maine, Orono, ME 04469, USA.
authors.forename: Patrick S
authors.initials: PS
authors.lastname: Spinney
authors.forename: Scott D
authors.initials: SD
authors.lastname: Collins
authors.forename: David G
authors.initials: DG
authors.lastname: Howitt
authors.forename: Rosemary L
authors.initials: RL
authors.lastname: Smith
mesh_terms: D015374:Biosensing Techniques; D002244:Carbon; D055664:Electrochemical Techniques; D004867:Equipment Design; D008855:Microscopy, Electron, Scanning; D016252:Microscopy, Scanning Tunneling; D058608:Nanopores / Q000648:ultrastructure; D036103:Nanotechnology; D053770:Nanowires / Q000737:chemistry / Q000648:ultrastructure; D017422:Sequence Analysis, DNA / Q000379:methods*
chemical_list: D002244:Carbon