title: The effect of toll-like receptor 4 in the aqueous humor of endotoxin-induced uveitis.
abstract: In our previous study, we found that acute anterior uveitis (AAU) could be induced in wild-type mice (C3H/HeN), but it could not be induced in TLR4 gene-deficient mice (C3H/HeJ), we concluded that the translocation of transcription factor nuclear factor-κB (NF-κB) may play an important role. In this study, we examined the concentration of different cytokines in the aqueous humor of C3H/HeN mice and C3H/HeJ mice with the aim of exploring the role of different cytokines in the lipopolysaccharide (LPS) and TLR4-mediated signal transduction in the development of AAU.
authors.affiliation: Department of Ophthalmology, Chaoyang Hospital ,Capital Medical University, No. 8 Baijiazhuang Road, Chaoyang District, Beijing 100020, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.affiliation: Department of Ophthalmology, Chaoyang Hospital ,Capital Medical University, No. 8 Baijiazhuang Road, Chaoyang District, Beijing 100020, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Lu
authors.affiliation: Department of Ophthalmology, Chaoyang Hospital ,Capital Medical University, No. 8 Baijiazhuang Road, Chaoyang District, Beijing 100020, China.
authors.forename: Yingzhi
authors.initials: Y
authors.lastname: Xu
authors.affiliation: Department of Ophthalmology, Chaoyang Hospital ,Capital Medical University, No. 8 Baijiazhuang Road, Chaoyang District, Beijing 100020, China.
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Hu
authors.affiliation: Department of Ophthalmology, Haidian Maternal and Child Health Hospital, Tongji Medical University, Beijing 100080, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.affiliation: Department of Ophthalmology, Chaoyang Hospital ,Capital Medical University, No. 8 Baijiazhuang Road, Chaoyang District, Beijing 100020, China.
authors.forename: Shang
authors.initials: S
authors.lastname: Li
mesh_terms: D000818:Animals; D001082:Aqueous Humor / Q000737:chemistry / Q000378:metabolism*; D004731:Endotoxins; D007371:Interferon-gamma / Q000032:analysis / Q000378:metabolism; D007375:Interleukin-1 / Q000032:analysis / Q000378:metabolism; D016753:Interleukin-10 / Q000032:analysis / Q000378:metabolism; D015850:Interleukin-6 / Q000032:analysis / Q000378:metabolism; D008070:Lipopolysaccharides; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D015398:Signal Transduction; D051197:Toll-Like Receptor 4 / Q000502:physiology*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis / Q000378:metabolism; D014605:Uveitis / Q000378:metabolism*
chemical_list: D004731:Endotoxins; D007375:Interleukin-1; D015850:Interleukin-6; D008070:Lipopolysaccharides; D051197:Toll-Like Receptor 4; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10; D007371:Interferon-gamma