title: Neuronal subtype specification in the cerebellum and dorsal hindbrain.
abstract: In the nervous system, there are hundreds to thousands of neuronal cell types that have morphologically, physiologically, and histochemically different characteristics and this diversity may enable us to elicit higher brain function. A better understanding of the molecular machinery by which neuron subtype specification occurs is thus one of the most important issues in brain science. The dorsal hindbrain, including the cerebellum, is a good model system to study this issue because a variety of types of neurons are produced from this region. Recently developed genetic lineage-tracing methods in addition to gene-transfer technologies have clarified a fate map of neurons produced from the dorsal hindbrain and accelerated our understanding of the molecular machinery of neuronal subtype specification in the nervous system.
authors.affiliation: Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), 4-1-1 Ogawahigashi, Kodaira, Tokyo 187-8502, Japan. hoshino@ncnp.go.jp
authors.forename: Mikio
authors.initials: M
authors.lastname: Hoshino
mesh_terms: D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics / Q000378:metabolism; D019070:Cell Lineage; D002467:Cell Nucleus / Q000378:metabolism; D002531:Cerebellum / Q000166:cytology / Q000196:embryology / Q000502:physiology*; D004622:Embryo, Mammalian / Q000166:cytology / Q000502:physiology; D018507:Gene Expression Regulation, Developmental; D051379:Mice; D008959:Models, Neurological; D046569:Neuroepithelial Cells / Q000166:cytology / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D017434:Protein Structure, Tertiary; D012249:Rhombencephalon / Q000166:cytology / Q000196:embryology / Q000502:physiology*
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; C500943:Atoh1 protein, mouse; C420992:Olig3 protein, mouse