title: High-throughput screening strategies for targeted identification of therapeutic compounds in colorectal cancer.
abstract: Recent advancements in understanding the role of both genetics and molecular pathways in the formation and progression of colorectal cancer have allowed the identification of factors that may be targeted for drug discovery. During the past decade, various approaches have been developed to target specific steps or components of these pathways in order to prevent the development and progression of colorectal cancer and to treat this disease. The innovation and optimization of high-throughput screening methods, as well as the recent emphasis from the NIH on translational sciences, have enabled rapid progress in drug discovery in many fields, including colorectal cancer. Here we present a summary of the recent efforts of targeted high-throughput drug discovery directed at pathways affected in colorectal cancer.
authors.affiliation: Department of Medicine, Stony Brook University School of Medicine, HSC-T17 Room 090, Stony Brook, NY 11794, USA. abialkow@sbumed.org
authors.forename: Agnieszka B
authors.initials: AB
authors.lastname: Bialkowska
authors.forename: Vincent W
authors.initials: VW
authors.lastname: Yang
mesh_terms: D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D015195:Drug Design; D055808:Drug Discovery; D057166:High-Throughput Screening Assays / Q000379:methods*; D006801:Humans; D058990:Molecular Targeted Therapy / Q000379:methods*; D060449:Wnt Signaling Pathway / Q000502:physiology; D051176:beta Catenin / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism
chemical_list: D051176:beta Catenin