title: Gold nanoparticle-induced formation of artificial protein capsids.
abstract: Gold nanoparticles are generally considered to be biologically inactive. However, in this study we show that the addition of 1.4 nm diameter gold nanoparticle induces the remodeling of the ring-shaped protein TRAP into a hollow, capsid-like configuration. This structural remodeling is dependent upon the presence of cysteine residues on the TRAP surface as well as the specific type of gold nanoparticle. The results reveal an apparent novel catalytic role of gold nanoparticles.
authors.affiliation: Graduate School of Materials Science, Nara Institute of Science and Technology (NAIST), and CREST, Japan Science and Technology Agency, 8916-5 Takayama, Ikoma, Nara 630-0192, Japan.
authors.forename: Ali D
authors.initials: AD
authors.lastname: Malay
authors.forename: Jonathan G
authors.initials: JG
authors.lastname: Heddle
authors.forename: Satoshi
authors.initials: S
authors.lastname: Tomita
authors.forename: Kenji
authors.initials: K
authors.lastname: Iwasaki
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Miyazaki
authors.forename: Koji
authors.initials: K
authors.lastname: Sumitomo
authors.forename: Hisao
authors.initials: H
authors.lastname: Yanagi
authors.forename: Ichiro
authors.initials: I
authors.lastname: Yamashita
authors.forename: Yukiharu
authors.initials: Y
authors.lastname: Uraoka
mesh_terms: D002213:Capsid / Q000737:chemistry*; D002384:Catalysis; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry*; D008958:Models, Molecular; D010316:Particle Size; D015202:Protein Engineering; D013499:Surface Properties
chemical_list: D006046:Gold