title: Exposure to bisphenol A is associated with low-grade albuminuria in Chinese adults.
abstract: Bisphenol A is an industrial chemical widely used in plastic products with a consequent exposure to humans. To assess whether exposure to bisphenol A is associated with renal disease, we searched for low-grade albuminuria in 3055 Chinese adults in the Shanghai metropolitan area aged 40 years or older. Using a value for urinary albumin-to-creatinine ratios <30 mg/g, we examined its association with urinary bisphenol A. Participants in the highest compared to the lowest quartile of urinary bisphenol A concentrations were significantly more likely to have low-grade albuminuria. Multivariate stepwise linear regression analysis, adjusted for potential confounding factors, showed that urinary bisphenol A was an independent determinant of the urinary albumin-to-creatinine ratio significantly associated with an increased risk of low-grade albuminuria with an adjusted odds ratio of 1.23 for the highest compared to the lowest concentration quartiles. This association was not modified by conventional risk factors such as age, gender, smoking, alcohol consumption, body mass index, hypertension, diabetes, and the estimated glomerular filtration rate. There was no significant relationship between bisphenol A and combined micro- and macroalbuminuria. Thus, our study lends support to a potential relation between bisphenol A exposure and an increased risk of low-grade albuminuria.
authors.affiliation: Department of Endocrinology and Metabolism, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, E-Institute of Shanghai Universities, Shanghai, China.
authors.forename: Mian
authors.initials: M
authors.lastname: Li
authors.forename: Yufang
authors.initials: Y
authors.lastname: Bi
authors.forename: Lu
authors.initials: L
authors.lastname: Qi
authors.forename: Tiange
authors.initials: T
authors.lastname: Wang
authors.forename: Min
authors.initials: M
authors.lastname: Xu
authors.forename: Yun
authors.initials: Y
authors.lastname: Huang
authors.forename: Yu
authors.initials: Y
authors.lastname: Xu
authors.forename: Yuhong
authors.initials: Y
authors.lastname: Chen
authors.forename: Jieli
authors.initials: J
authors.lastname: Lu
authors.forename: Weiqing
authors.initials: W
authors.lastname: Wang
authors.forename: Guang
authors.initials: G
authors.lastname: Ning
mesh_terms: D000328:Adult; D000368:Aged; D000419:Albuminuria / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis / Q000208:ethnology / Q000652:urine; D044466:Asian People / Q000706:statistics & numerical data; D001559:Benzhydryl Compounds; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D004781:Environmental Exposure; D004785:Environmental Pollutants / Q000009:adverse effects* / Q000097:blood; D005260:Female; D006801:Humans; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D010636:Phenols / Q000009:adverse effects* / Q000097:blood; D018570:Risk Assessment; D012307:Risk Factors; D012720:Severity of Illness Index; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D004785:Environmental Pollutants; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds