title: Photo-crosslinked biodegradable hydrogels prepared from fumaric acid monoethyl ester-functionalized oligomers for protein delivery.
abstract: Photo-crosslinkable, fumaric acid monoethyl ester-functionalized triblock oligomers are synthesized and copolymerized with N-vinyl-2-pyrrolidone to form biodegradable photo-crosslinked hydrogels. Poly(ethylene glycol) is used as the middle hydrophilic segment and the hydrophobic segments are based on D,L-lactide, trimethylene carbonate or a mixture of these monomers. Two model proteins, lysozyme and albumin, are incorporated in the hydrogels and their release is studied. The composition of the hydrophobic segments could be used to tune degradation behavior and release rates. Careful optimization of photo-polymerization conditions is needed to limit conjugation of proteins to the hydrogels and protein denaturation.
authors.affiliation: Faculty of Science and Technology, Department of Biomaterials Science and Technology, MIRA Institute for Biomedical Technology and Technical Medicine, University of Twente, P.O. Box 217, 7500 AE, Enschede, The Netherlands.
authors.forename: Janine
authors.initials: J
authors.lastname: Jansen
authors.forename: George
authors.initials: G
authors.lastname: Mihov
authors.forename: Jan
authors.initials: J
authors.lastname: Feijen
authors.forename: Dirk W
authors.initials: DW
authors.lastname: Grijpma
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis*; D002417:Cattle; D003432:Cross-Linking Reagents / Q000737:chemistry; D004146:Dioxanes / Q000737:chemistry; D004337:Drug Carriers / Q000138:chemical synthesis*; D005650:Fumarates / Q000737:chemistry*; D020100:Hydrogels / Q000138:chemical synthesis*; D057927:Hydrophobic and Hydrophilic Interactions; D009682:Magnetic Resonance Spectroscopy; D009113:Muramidase / Q000737:chemistry; D055668:Photochemical Processes; D011092:Polyethylene Glycols / Q000737:chemistry*; D058105:Polymerization; D011760:Pyrrolidinones / Q000737:chemistry; D012710:Serum Albumin, Bovine / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D004146:Dioxanes; D004337:Drug Carriers; D005650:Fumarates; D020100:Hydrogels; D011760:Pyrrolidinones; D012710:Serum Albumin, Bovine; D011092:Polyethylene Glycols; C443643:trimethylene carbonate; C042670:N-vinyl-2-pyrrolidinone; C091880:dilactide; D009113:Muramidase; C061175:ethyl fumarate