title: Houttuynoids A-E, anti-herpes simplex virus active flavonoids with novel skeletons from Houttuynia cordata.
abstract: Houttuynoids A-E (1-5), a new type of flavonoid with houttuynin tethered to hyperoside, and their presumed biosynthetic precursor hyperoside (6) were isolated from the whole plant of Houttuynia cordata. Their structures were elucidated by analysis of 1D and 2D NMR. A hypothetical biogenetic pathway for houttuynoids A-E was proposed. Compounds 1-5 exhibited potent anti-HSV (herpes simplex viruses) activity.
authors.affiliation: Institute of Traditional Chinese Medicine & Natural Products, Jinan University, Guangzhou 510632, People's Republic of China.
authors.forename: Shao-Dan
authors.initials: SD
authors.lastname: Chen
authors.forename: Hao
authors.initials: H
authors.lastname: Gao
authors.forename: Qin-Chang
authors.initials: QC
authors.lastname: Zhu
authors.forename: Ya-Qi
authors.initials: YQ
authors.lastname: Wang
authors.forename: Ting
authors.initials: T
authors.lastname: Li
authors.forename: Zhen-Qiang
authors.initials: ZQ
authors.lastname: Mu
authors.forename: Hong-Ling
authors.initials: HL
authors.lastname: Wu
authors.forename: Tao
authors.initials: T
authors.lastname: Peng
authors.forename: Xin-Sheng
authors.initials: XS
authors.lastname: Yao
mesh_terms: D000212:Acyclovir / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D052859:Houttuynia / Q000737:chemistry*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018139:Simplexvirus / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D005419:Flavonoids; D000212:Acyclovir