title: Low cardiometabolic risk in Parkinson's disease is independent of nutritional status, body composition and fat distribution.
abstract: OBJECTIVE
  To investigate if the reduced cardiometabolic risk in Parkinson's disease (PD) is independent of nutritional status, body composition and fat distribution.
  
  
  METHODS
  We designed a case-control study comparing 80 non underweight PD patients with 80 controls matched for sex, age and body mass index (BMI). Nutritional assessment included: anthropometry (BMI and waist circumference [WC]), body composition estimated by impedance and biochemistry (fasting glucose, serum lipids and transaminases). The presence of arterial hypertension, diabetes mellitus and metabolic syndrome (MetS) were noted.
  
  
  RESULTS
  Compared to controls and independently of gender, PD patients showed lower percentage of body fat (P < 0.001) and biochemical parameters (glucose, P < 0.001; total cholesterol, P < 0.001; LDL, P < 0.001; triglycerides, P = 0.002; alanine aminotransferase, P < 0.001 and aspartate aminotransferase, P = 0.015) but similar WC (P = 0.324). The prevalence of hypertension and MetS was similar in the two groups, as well as the frequency and the number of MetS criteria. The relationship between PD and low cardiometabolic profile was independent of age, gender, current smoking and BMI. After adjusting for WC and body fat, most of the associations remained significant.
  
  
  CONCLUSIONS
  PD patients seem to have a more favorable cardiometabolic risk profile, independently of nutritional status, body composition and fat distribution.
authors.affiliation: Parkinson Institute, Istituti Clinici di Perfezionamento, Milano, Italy. e.cereda@smatteo.pv.it
authors.forename: Emanuele
authors.initials: E
authors.lastname: Cereda
authors.forename: Erica
authors.initials: E
authors.lastname: Cassani
authors.forename: Michela
authors.initials: M
authors.lastname: Barichella
authors.forename: Angela
authors.initials: A
authors.lastname: Spadafranca
authors.forename: Riccardo
authors.initials: R
authors.lastname: Caccialanza
authors.forename: Simona
authors.initials: S
authors.lastname: Bertoli
authors.forename: Alberto
authors.initials: A
authors.lastname: Battezzati
authors.forename: Gianni
authors.initials: G
authors.lastname: Pezzoli
mesh_terms: D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D001823:Body Composition; D050218:Body Fat Distribution; D015992:Body Mass Index; D016022:Case-Control Studies; D008078:Cholesterol, LDL / Q000097:blood; D003920:Diabetes Mellitus / Q000453:epidemiology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D008297:Male; D024821:Metabolic Syndrome / Q000453:epidemiology; D008875:Middle Aged; D009752:Nutritional Status; D010300:Parkinson Disease / Q000453:epidemiology*; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference
chemical_list: D001786:Blood Glucose; D008078:Cholesterol, LDL; D014280:Triglycerides; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase