title: Light white oils exhibit low tissue accumulation potential and minimal toxicity in F344 rats.
abstract: Female F344 rats were fed diets containing 0.02%, 0.2%, or 2.0% white mineral oil for 90 days. There were no gross or microscopic differences in target organs at the 0.02% level. In the higher-dose groups, relative liver and mesenteric lymph node (MLN) weights were increased, and MLN inflammation was observed. At the 2% level, there was very limited evidence of microgranuloma formation in the liver but at a lower incidence and at lesser severity than has been reported in studies of C₂₂-C₂₅ oils. Analysis of liver extracts from treated rats revealed that C₁₅-C₂₀ constituents were underrepresented by comparison to their corresponding concentrations in the test oil. These results provide evidence that although hydrocarbons with carbon numbers < C₂₀ are absorbed, they are not preferentially retained and do not contribute to inflammatory processes in liver.
authors.affiliation: Exxon Biomedical Sciences, Inc, 1545 US Highway 22 East, Annandale, NJ 08801, USA. richard.h.mckee@exxonmobil.com
authors.forename: Richard H
authors.initials: RH
authors.lastname: McKee
authors.forename: John G
authors.initials: JG
authors.lastname: Drummond
authors.forename: James J
authors.initials: JJ
authors.lastname: Freeman
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Letinski
authors.forename: Mary Jo
authors.initials: MJ
authors.lastname: Miller
mesh_terms: D000818:Animals; D005260:Female; D006099:Granuloma / Q000139:chemically induced; D006838:Hydrocarbons / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008198:Lymph Nodes / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008899:Mineral Oil / Q000493:pharmacokinetics / Q000633:toxicity*; D008970:Molecular Weight; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D006838:Hydrocarbons; D008899:Mineral Oil