title: Copper-catalyzed asymmetric 1,4-addition of alkenyl alanes to N-substituted-2-3-dehydro-4-piperidones.
abstract: Readily available vinyl alanes are used in the Cu-catalyzed asymmetric conjugate addition reaction to N-substituted-2-3-dehydro-4-piperidones. The enhanced reactivity of recently developed and easily prepared phosphine amine ligands in combination with inexpensive Cu(II)naphtenate (CuNp) allows the introduction of a great variety of alkenyl, alkyl, and aryl aluminums in high enantioselectivity.
authors.affiliation: Department of Organic Chemistry, University of Geneva 30, quai Ernest Ansermet, CH-1211 Geneva 4, Switzerland.
authors.forename: Daniel
authors.initials: D
authors.lastname: Müller
authors.forename: Alexandre
authors.initials: A
authors.lastname: Alexakis