title: Polymorphisms in genes encoding mt-tRNA in female breast cancer in Poland.
abstract: Recently, there have been indications of participation of mitochondria in the carcinogenic process and the role of polymorphisms in increasing the risk of cancer. The aim of the study was to detect possible changes in the sequence of 22 genes encoding mitochondrial tRNA in breast cancer carcinoma, which take part in protein synthesis in the translation process. The analysis of tumour tissue and blood material sampled from 50 patients revealed that few mutations have been found. It cannot be excluded that, through their impact on the secondary and tertiary tRNA structure, polymorphisms may cause mitochondrial dysfunction and contribute to appearance of other changes in mtDNA. Mutations in tRNA genes in breast cancer may affect the cell and cause its dysfunction, as in mitochondrial diseases.
authors.affiliation: Department of Oncology, Medical University of Lublin, Jaczewskiego 7, 20-090 Lublin, Poland. ludgr@poczta.onet.pl
authors.forename: Ludmila
authors.initials: L
authors.lastname: Grzybowska-Szatkowska
authors.forename: Brygida
authors.initials: B
authors.lastname: Slaska
mesh_terms: D001483:Base Sequence; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000235:genetics* / Q000473:pathology; D004272:DNA, Mitochondrial / Q000235:genetics*; D005260:Female; D006239:Haplotypes; D006801:Humans; D008875:Middle Aged; D008928:Mitochondria / Q000235:genetics / Q000473:pathology; D028361:Mitochondrial Diseases / Q000235:genetics / Q000473:pathology; D008969:Molecular Sequence Data; D009154:Mutation; D011044:Poland; D011110:Polymorphism, Genetic; D012343:RNA, Transfer / Q000235:genetics*; D017422:Sequence Analysis, DNA
chemical_list: D004272:DNA, Mitochondrial; D012343:RNA, Transfer