title: Increased risk of noninfluenza respiratory virus infections associated with receipt of inactivated influenza vaccine.
abstract: We randomized 115 children to trivalent inactivated influenza vaccine (TIV) or placebo. Over the following 9 months, TIV recipients had an increased risk of virologically-confirmed non-influenza infections (relative risk: 4.40; 95% confidence interval: 1.31-14.8). Being protected against influenza, TIV recipients may lack temporary non-specific immunity that protected against other respiratory viruses.
authors.affiliation: School of Public Health, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Pokfulam, Hong Kong SAR, China. bcowling@hku.hk
authors.forename: Benjamin J
authors.initials: BJ
authors.lastname: Cowling
authors.forename: Vicky J
authors.initials: VJ
authors.lastname: Fang
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Nishiura
authors.forename: Kwok-Hung
authors.initials: KH
authors.lastname: Chan
authors.forename: Sophia
authors.initials: S
authors.lastname: Ng
authors.forename: Dennis K M
authors.initials: DK
authors.lastname: Ip
authors.forename: Susan S
authors.initials: SS
authors.lastname: Chiu
authors.forename: Gabriel M
authors.initials: GM
authors.lastname: Leung
authors.forename: J S Malik
authors.initials: JS
authors.lastname: Peiris
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy; D015994:Incidence; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000009:adverse effects*; D008297:Male; D010919:Placebos / Q000008:administration & dosage; D012141:Respiratory Tract Infections / Q000453:epidemiology* / Q000276:immunology; D018570:Risk Assessment; D015164:Vaccines, Inactivated / Q000008:administration & dosage / Q000009:adverse effects; D014777:Virus Diseases / Q000453:epidemiology* / Q000276:immunology
chemical_list: D007252:Influenza Vaccines; D010919:Placebos; D015164:Vaccines, Inactivated