title: Trends and challenges in tuberculosis in a medium-sized southern European setting.
abstract: Trends in tuberculosis (TB) admissions over 40 years at the Infectious Diseases Clinic of Perugia University Hospital, Perugia, Italy, show that in the last decade non-Italian TB case admissions outweighed those of Italians, with a large number of cases from Eastern Europe (25.2%) and  Africa (23.4%). Non-Italians tended to be younger and were generally new pulmonary TB cases, and drug resistance was also more common. Overall, the number of multidrug-resistant cases increased. Only one case occurred in a native-born Italian, and five of seven cases had newly diagnosed TB.  In low TB incidence settings such as Perugia, Italy, TB prevention and control programmes for the foreign-born need to be reinforced.
authors.affiliation: Infectious Disease Clinic Section, Department of Experimental Medicine and Biochemical Sciences, Perugia University, Perugia, Italy. pasticci@unipg.it
authors.forename: M B
authors.initials: MB
authors.lastname: Pasticci
authors.forename: R
authors.initials: R
authors.lastname: Mazzolla
authors.forename: A
authors.initials: A
authors.lastname: Mercuri
authors.forename: G
authors.initials: G
authors.lastname: Gamboni
authors.forename: J C
authors.initials: JC
authors.lastname: Bombaci
authors.forename: C
authors.initials: C
authors.lastname: Tiecco
authors.forename: M
authors.initials: M
authors.lastname: Rubeca
authors.forename: R
authors.initials: R
authors.lastname: Papili
authors.forename: F
authors.initials: F
authors.lastname: Pasticci
authors.forename: L
authors.initials: L
authors.lastname: Casali
authors.forename: G
authors.initials: G
authors.lastname: Ferrara
authors.forename: F
authors.initials: F
authors.lastname: Baldelli
mesh_terms: D000328:Adult; D000367:Age Factors; D000995:Antitubercular Agents / Q000627:therapeutic use*; D024881:Drug Resistance, Bacterial; D054242:Emigrants and Immigrants / Q000706:statistics & numerical data; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data; D006785:Hospitals, University; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012189:Retrospective Studies; D014376:Tuberculosis / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology
chemical_list: D000995:Antitubercular Agents