title: Herlyn-Werner-Wunderlich syndrome: MRI findings, radiological guide (two cases and literature review), and differential diagnosis.
abstract: BACKGROUND
  Herlyn-Werner-Wunderlich (HWW) syndrome is a very rare congenital anomaly of the urogenital tract involving Müllerian ducts and Wolffian structures, and it is characterized by the triad of didelphys uterus, obstructed hemivagina and ipsilateral renal agenesis. It generally occurs at puberty and exhibits non-specific and variable symptoms with acute or pelvic pain shortly following menarche, causing a delay in the diagnosis. Moreover, the diagnosis is complicated by the infrequency of this syndrome, because Müllerian duct anomalies (MDA) are infrequently encountered in a routine clinical setting.
  
  
  METHODS
  two cases of HWW syndrome in adolescents and a differential diagnosis for one case of a different MDA, and the impact of magnetic resonance (MR) imaging technology to achieve the correct diagnosis.
  
  
  CONCLUSIONS
  MR imaging is a very suitable diagnostic tool in order to perform the correct diagnosis of HWW syndrome.
authors.affiliation: Department of Radiology, Campus Bio-Medico Univeristy of Rome, Italy. r.delvescovo@unicampus.it
authors.forename: Riccardo
authors.initials: R
authors.lastname: Del Vescovo
authors.forename: Sofia
authors.initials: S
authors.lastname: Battisti
authors.forename: Valerio
authors.initials: V
authors.lastname: Di Paola
authors.forename: Claudia L
authors.initials: CL
authors.lastname: Piccolo
authors.forename: Roberto L
authors.initials: RL
authors.lastname: Cazzato
authors.forename: Ilaria
authors.initials: I
authors.lastname: Sansoni
authors.forename: Rosario F
authors.initials: RF
authors.lastname: Grasso
authors.forename: Bruno Beomonte
authors.initials: BB
authors.lastname: Zobel
mesh_terms: D000293:Adolescent; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007668:Kidney / Q000002:abnormalities; D008279:Magnetic Resonance Imaging; D009095:Mullerian Ducts / Q000002:abnormalities; D013577:Syndrome; D014564:Urogenital Abnormalities / Q000175:diagnosis*; D014599:Uterus / Q000002:abnormalities