title: TachoSil for postinfarction ventricular free wall rupture.
abstract: Despite a decline in the last three decades, postinfarction ventricular free wall rupture still complicates more than 3% of acute ST-elevation myocardial infarctions and remains a surgical challenge. TachoSil (Nycomed, Zurich, Switzerland) is an equine collagen patch coated with human fibrinogen and human thrombin, which has recently been used for haemostasis in cardiovascular surgery, but its potential usefulness in free wall rupture has not been reported. Initial clinical experience with an on-pump sutureless technique without cardioplegia, using wide TachoSil patching to achieve free wall rupture repair, has been described.
authors.affiliation: Department of Cardiovascular Sciences, Università degli Studi di Milano, Scientific Institute MultiMedica Hospital, Milan, Italy. marco.pocar@unimi.it
authors.forename: Marco
authors.initials: M
authors.lastname: Pocar
authors.forename: Davide
authors.initials: D
authors.lastname: Passolunghi
authors.forename: Alda
authors.initials: A
authors.lastname: Bregasi
authors.forename: Francesco
authors.initials: F
authors.lastname: Donatelli
mesh_terms: D000368:Aged; D006348:Cardiac Surgical Procedures; D002305:Cardiac Tamponade / Q000209:etiology / Q000601:surgery; D002315:Cardiopulmonary Bypass; D004338:Drug Combinations; D005260:Female; D005340:Fibrinogen / Q000627:therapeutic use*; D006342:Heart Rupture, Post-Infarction / Q000209:etiology / Q000601:surgery*; D006489:Hemostatic Techniques; D006490:Hemostatics / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D013917:Thrombin / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D004338:Drug Combinations; D006490:Hemostatics; C518955:TachoSil; D005340:Fibrinogen; D013917:Thrombin