title: Pulmonary lymphoepithelioma-like carcinoma with rapid progression.
abstract: Pulmonary lymphoepithelioma-like carcinoma (LELC) is a rare entity, commonly associated in East Asia with Epstein-Barr virus (EBV) infection. A 71-year-old woman underwent partial resection of the left lower lobe for a 17-mm nodule and was subsequently diagnosed with pulmonary LELC. Six months postoperatively, chest computed tomography (CT) showed lymphadenopathy in the left hilum and a 16-mm nodule in the S6 segment of the left lower lobe that had been difficult to point out (3 mm in size) at the initial surgery. She underwent a second surgical resection because of rapid progression-a clinical course at variance with the generally good prognosis for pulmonary LELC. At admission, the EBV deoxyribonucleic acid (DNA) blood level was 40 copies/μg. The EBV DNA was undetectable after the second surgery.
authors.affiliation: Department of Thoracic Surgery, Kyoto University, Sakyo-ku, Kyoto, Japan. satonat@nmc-kobe.org
authors.forename: Satona
authors.initials: S
authors.lastname: Tanaka
authors.forename: Fengshi
authors.initials: F
authors.lastname: Chen
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Date
mesh_terms: D000368:Aged; D002277:Carcinoma / Q000556:secondary* / Q000601:surgery / Q000821:virology; D004279:DNA, Viral / Q000097:blood; D018450:Disease Progression; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D017403:In Situ Hybridization; D008175:Lung Neoplasms / Q000473:pathology* / Q000601:surgery / Q000821:virology; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology* / Q000601:surgery; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D011013:Pneumonectomy; D012086:Reoperation; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D019562:Viral Load
chemical_list: D004279:DNA, Viral