title: No association between catechol-O-methyltransferase polymorphisms and neurotic disorders among mainland Chinese university students.
abstract: This study investigates the genetic association between catechol-O-methyltransferase (COMT) gene polymorphisms and neurotic disorders. Data were derived from a case-control association study of 255 undergraduates affected by neurotic disorders and 269 matched healthy undergraduate controls. The polymorphisms of eight tag single nucleotide polymorphisms (SNPs) on the COMT gene were tested using polymerase chain reaction (PCR)-based Ligase Detection Reaction (PCR-LDR). The eight tag SNPs on the COMT gene assessed were not associated with neurotic disorders. Our finding suggests that the COMT gene may not be a susceptibility gene for neurotic disorders.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, China.
authors.forename: Changgui
authors.initials: C
authors.lastname: Kou
authors.forename: Xiangfei
authors.initials: X
authors.lastname: Meng
authors.forename: Bing
authors.initials: B
authors.lastname: Xie
authors.forename: Jieping
authors.initials: J
authors.lastname: Shi
authors.forename: Qiong
authors.initials: Q
authors.lastname: Yu
authors.forename: Yaqin
authors.initials: Y
authors.lastname: Yu
authors.forename: Carl
authors.initials: C
authors.lastname: D'Arcy
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics* / Q000523:psychology; D016022:Case-Control Studies; D002394:Catechol O-Methyltransferase / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies / Q000379:methods / Q000706:statistics & numerical data*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008297:Male; D009497:Neurotic Disorders / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D013334:Students / Q000523:psychology; D014495:Universities
chemical_list: D002394:Catechol O-Methyltransferase