title: Key concepts in glioblastoma therapy.
abstract: Glioblastoma is the most common form of primary brain cancer and remains one of the most aggressive forms of human cancer. Current standard of care involves maximal surgical resection followed by concurrent therapy with radiation and the DNA alkylating agent temozolomide. Despite this aggressive regimen, the median survival remains approximately 14 months. Meaningful strategies for therapeutic intervention are desperately needed. Development of such strategies will require an understanding of the therapeutic concepts that have evolved over the past three decades. This article reviews the key principles that drive the formulation of therapeutic strategies in glioblastoma. Specifically, the concepts of tumour heterogeneity, oncogene addiction, non-oncogene addiction, tumour initiating cells, tumour microenvironment, non-coding sequences and DNA damage response will be reviewed.
authors.affiliation: Department of Neurosurgery, Karolinska University Hospital, Stockholm, Sweden.
authors.forename: Jiri
authors.initials: J
authors.lastname: Bartek
authors.forename: Kimberly
authors.initials: K
authors.lastname: Ng
authors.forename: Jiri
authors.initials: J
authors.lastname: Bartek
authors.forename: Walter
authors.initials: W
authors.lastname: Fischer
authors.forename: Bob
authors.initials: B
authors.lastname: Carter
authors.forename: Clark C
authors.initials: CC
authors.lastname: Chen
mesh_terms: D001932:Brain Neoplasms / Q000235:genetics* / Q000628:therapy; D003131:Combined Modality Therapy; D004249:DNA Damage / Q000235:genetics; D004273:DNA, Neoplasm / Q000235:genetics; D005909:Glioblastoma / Q000235:genetics* / Q000628:therapy; D006801:Humans; D009857:Oncogenes / Q000235:genetics; D022661:RNA, Untranslated / Q000235:genetics
chemical_list: D004273:DNA, Neoplasm; D022661:RNA, Untranslated