title: Acral histiocytic nodules: a possible new variant of non-X histiocytosis.
abstract: Many types of histiocytoses have been described. We present a case of a 56-year-old woman who presented with multiple nodules on the hands. On histological examination of an excision biopsy, a mainly dermal lesion was seen, with scattered mononuclear inflammatory cells and occasional multinucleated cells in the background. The tumour was composed of short spindle-shaped histiocyte-like cells with vesicular nuclei and small nucleoli. These cells were positive for CD68 and focally positive for smooth-muscle actin. There was no lipid or haemosiderin pigment, and no cholesterol clefts. Further investigations did not find evidence of bony or systemic involvement. The non-Langerhans cell histiocytoses, also known as non-X histiocytoses, are rare and of unknown aetiology. Clinicopathologically, this case does not seem to fit with any of the recognized subtypes, and we propose that it may represent a previously undescribed variant of the disease.
authors.affiliation: Department of Dermatology, Nottingham University Hospitals NHS Trust, Queen's Medical Centre, Nottingham, Nottinghamshire, UK. dranandpatel@doctors.net.uk
authors.forename: A N
authors.initials: AN
authors.lastname: Patel
authors.forename: S N
authors.initials: SN
authors.lastname: Cohen
authors.forename: I H
authors.initials: IH
authors.lastname: Leach
authors.forename: K
authors.initials: K
authors.lastname: Scharrer
mesh_terms: D015415:Biomarkers / Q000032:analysis; D005260:Female; D005385:Fingers; D006229:Hand Dermatoses / Q000175:diagnosis*; D015614:Histiocytosis / Q000175:diagnosis*; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged
chemical_list: D015415:Biomarkers