title: Direct heteroarylation of tautomerizable heterocycles into unsymmetrical and symmetrical biheterocycles via Pd/Cu-catalyzed phosphonium coupling.
abstract: The direct cross-coupling of tautomerizable heterocycles with various unfunctionalized heteroarenes has been achieved through PyBroP-mediated and Pd/Cu-catalyzed sequential C-OH/C-H activation. The methodology allows a facile entry into novel diazine-azole biheterocyclic frameworks. Moreover, an unprecedented Pd-catalyzed phosphonium homocoupling of tautomerizable heterocycles was also developed to afford a direct synthetic route to symmetrical 1,2-, 1,3-, and 1,4-bidiazine units.
authors.affiliation: Laboratory for Organic & Microwave-Assisted Chemistry, Department of Chemistry, University of Leuven, Celestijnenlaan 200F, B-3001, Leuven, Belgium.
authors.forename: Abhishek
authors.initials: A
authors.lastname: Sharma
authors.forename: Dipak
authors.initials: D
authors.lastname: Vachhani
authors.forename: Erik
authors.initials: E
authors.lastname: Van der Eycken
mesh_terms: D001393:Azoles / Q000138:chemical synthesis; D002384:Catalysis; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D009943:Organophosphorus Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*
chemical_list: D001393:Azoles; D006571:Heterocyclic Compounds; D009943:Organophosphorus Compounds; D010165:Palladium