title: Association between hippocampal volume and serum adiponectin in patients with type 2 diabetes mellitus.
abstract: Type 2 diabetes mellitus (DM) is associated with cognitive dysfunction and hippocampus volume. The aim of the present study was to test the hypothesis that the level of the adipocytokine adiponectin correlates with hippocampus volume and insulin resistance in patients with type 2 DM. A total of 45 patients with type 2 DM were divided into two groups: a low adiponectin group and a normal adiponectin group. Hippocampus volume was measured by computer-assisted analysis using a magnetic resonance imaging (MRI) voxel-based specific regional analysis system developed for the study of Alzheimer's disease as the end point for assessment of hippocampus volume. Mean hippocampus volume was lower in the low adiponectin group than in the normal adiponectin group (P<.0001). Fasting serum concentrations of glucose (P<.05) and insulin (P<.0001), and homeostasis model assessment index (P<.0001), were all higher in the low adiponectin group than in the normal adiponectin group. Multiple regression analysis showed that hippocampus volume independently predicted serum adiponectin level. These results suggest that circulating levels of adiponectin are related to hippocampus volume in patients with type 2 DM.
authors.affiliation: Department of Internal Medicine, Oita University Oita, Japan. masaki@oita-u.ac.jp
authors.forename: Takayuki
authors.initials: T
authors.lastname: Masaki
authors.forename: Futoshi
authors.initials: F
authors.lastname: Anan
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Shimomura
authors.forename: Minoru
authors.initials: M
authors.lastname: Fujiki
authors.forename: Tetsunori
authors.initials: T
authors.lastname: Saikawa
authors.forename: Hironobu
authors.initials: H
authors.lastname: Yoshimatsu
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000368:Aged; D044466:Asian People; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D003071:Cognition; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000473:pathology*; D005215:Fasting; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D007004:Hypoglycemic Agents / Q000097:blood; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D007564:Japan; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009929:Organ Size; D011581:Psychological Tests
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin