title: Comparison of treatment adherence between selective serotonin reuptake inhibitors and moclobemide in patients with social anxiety disorder.
abstract: OBJECTIVE
  With respect to the pharmacotherapy of social anxiety disorder (SAD), it has been suggested that treatment duration is an important factor that can significantly predict responses. The present study aimed to compare the treatment adherence of SAD patients who were taking either SSRIs or reversible inhibitors of MAO-A (moclobemide) by measuring treatment duration and all-cause discontinuation rates of pharmacotherapy in a natural clinical setting.
  
  
  METHODS
  We retrospectively analysed the data of 172 patients diagnosed with SAD. Depending on their medication, we divided the patients into two groups, SSRI (n=54) or moclobemide (n=118). The expected number of all-cause discontinuation every 2 weeks after starting treatment was calculated by life table survival methods. A multi-variable Cox proportional hazard regression was used to analyze the potential influence of explanatory variables.
  
  
  RESULTS
  Treatment duration was significantly longer in the SSRI group [46.41±56.96, median=12.0 (weeks)] than in the moclobemide group [25.53±34.74, median=12.0 (weeks), Z=2.352, p=0.019]. Overall, all-cause discontinuation rates were significantly lower with SSRIs (81%) than moclobemide (96%, χ²=4.532, p=0.033).
  
  
  CONCLUSIONS
  The SSRI group had a longer treatment duration and lower all-cause discontinuation rate than moclobemide. Further, only the type of medication had a significant effect on all-cause discontinuation rates and therefore, we could predict better treatment adherence with the SSRIs in the treatment of SAD.
authors.affiliation: Department of Psychiatry, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Se-Won
authors.initials: SW
authors.lastname: Lim
authors.forename: Yong-Seok
authors.initials: YS
authors.lastname: Kwon
authors.forename: Juwon
authors.initials: J
authors.lastname: Ha
authors.forename: Hyeng-Geun
authors.initials: HG
authors.lastname: Yoon
authors.forename: Seung-Min
authors.initials: SM
authors.lastname: Bae
authors.forename: Dong-Won
authors.initials: DW
authors.lastname: Shin
authors.forename: Young-Chul
authors.initials: YC
authors.lastname: Shin
authors.forename: Kang-Seob
authors.initials: KS
authors.lastname: Oh