title: Replication of results of genome-wide association studies on lung cancer susceptibility loci in a Korean population.
abstract: OBJECTIVE
  Genome-wide association studies (GWAS) have identified the three chromosomal regions, 5p15, 6p21 and 15q25, as being associated with lung cancer risk in European populations. This study was performed to confirm these associations in Korean patients with lung cancer.
  
  
  METHODS
  The genotypes at rs2736100, rs402710, rs401681 and rs31489 at 5p15, rs9295740 at 6p22, which is in extensive linkage disequilibrium with the 6p21 region, as well as rs2036534 and rs6495309 at 15q25, were determined in 1094 patients with lung cancer and 1100 healthy control subjects, who were frequency matched for age and gender.
  
  
  RESULTS
  The single-nucleotide polymorphisms (SNP) at 5p15 (rs2736100, adjusted odds ratio [aOR] 1.32, 95% confidence interval [CI] 1.03-1.67, P = 0.025; rs402710, aOR 0.82, 95% CI 0.69-0.98, P = 0.025; rs401681, aOR 0.82, 95% CI 0.69-0.98, P = 0.026) and at 15q25 (rs2036534, aOR 0.75, 95% CI 0.61-0.93, P = 0.01; rs6495309, aOR 0.81, 95% CI 0.65-1.00, P = 0.052) were significantly associated with lung cancer risk. The magnitude of the effect was similar to that reported in previous studies, and the association was in the same direction. The effect of SNP in the 5p15 region on the risk of lung cancer was significant only for adenocarcinoma. The two SNP in the 15q25 region were significantly associated with lung cancer risk in ever-smokers and in patients with squamous-cell carcinoma. However, there was no association between the SNP at 6p22 and lung cancer risk.
  
  
  CONCLUSIONS
  The association between SNP in the 5p15 and 15q25 regions and the risk of lung cancer was confirmed in a Korean population.
authors.affiliation: Departments of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Daegu, Korea.
authors.forename: Eun Young
authors.initials: EY
authors.lastname: Bae
authors.forename: Shin Yup
authors.initials: SY
authors.lastname: Lee
authors.forename: Bong Kyoon
authors.initials: BK
authors.lastname: Kang
authors.forename: Eun Jin
authors.initials: EJ
authors.lastname: Lee
authors.forename: Yi Young
authors.initials: YY
authors.lastname: Choi
authors.forename: Hyo-Gyoung
authors.initials: HG
authors.lastname: Kang
authors.forename: Jin Eun
authors.initials: JE
authors.lastname: Choi
authors.forename: Hyo-Sung
authors.initials: HS
authors.lastname: Jeon
authors.forename: Won Kee
authors.initials: WK
authors.lastname: Lee
authors.forename: Shin
authors.initials: S
authors.lastname: Kam
authors.forename: Kyung Min
authors.initials: KM
authors.lastname: Shin
authors.forename: Guang
authors.initials: G
authors.lastname: Jin
authors.forename: Seung Soo
authors.initials: SS
authors.lastname: Yoo
authors.forename: Jaehee
authors.initials: J
authors.lastname: Lee
authors.forename: Seung Ick
authors.initials: SI
authors.lastname: Cha
authors.forename: Chang Ho
authors.initials: CH
authors.lastname: Kim
authors.forename: Tae Hoon
authors.initials: TH
authors.lastname: Jung
authors.forename: Jae Yong
authors.initials: JY
authors.lastname: Park
mesh_terms: D000230:Adenocarcinoma / Q000208:ethnology / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D020022:Genetic Predisposition to Disease / Q000208:ethnology*; D055106:Genome-Wide Association Study; D006801:Humans; D015810:Linkage Disequilibrium; D008175:Lung Neoplasms / Q000208:ethnology / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D015203:Reproducibility of Results; D056910:Republic of Korea; D055752:Small Cell Lung Carcinoma / Q000208:ethnology / Q000235:genetics*