title: Four eremophilane sesquiterpenes from the mangrove endophytic fungus Xylaria sp. BL321.
abstract: Three new eremophilane sesquiterpenes (1-3) were isolated from the mangrove endophytic fungus Xylaria sp. BL321 together with 07H239-A (4), a known analogue of the new compounds. The structures of these compounds were elucidated by analysis of their MS, 1D and 2D NMR spectroscopic data. Compound 4 showed activation activity on α-glucosidase at 0.15 μM (146%), and then, 4 gradually produced inhibitory activity on α-glucosidase with increasing concentration, and the IC₅₀ value is 6.54 μM.
authors.affiliation: School of Chemistry and Chemical Engineering, Sun Yat-Sen University, 135 Xingang West Road, Guangzhou 510275, China.|CAS Key Laboratory of Marine Bio-resources Sustainable Utilization, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Rd., Guangzhou 510301, China.
authors.forename: Yongxiang
authors.initials: Y
authors.lastname: Song
authors.affiliation: School of Chemistry and Chemical Engineering, Sun Yat-Sen University, 135 Xingang West Road, Guangzhou 510275, China.
authors.forename: Jiajian
authors.initials: J
authors.lastname: Wang
authors.affiliation: School of Chemistry and Chemical Engineering, Sun Yat-Sen University, 135 Xingang West Road, Guangzhou 510275, China.|CAS Key Laboratory of Marine Bio-resources Sustainable Utilization, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Rd., Guangzhou 510301, China.
authors.forename: Hongbo
authors.initials: H
authors.lastname: Huang
authors.affiliation: School of Chemistry and Chemical Engineering, Sun Yat-Sen University, 135 Xingang West Road, Guangzhou 510275, China.
authors.forename: Lin
authors.initials: L
authors.lastname: Ma
authors.affiliation: Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism (Sun Yat-Sen University), Bureau of Education of Guangdong, Guangzhou, 510275, China.|School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510080, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Wang
authors.affiliation: Syngenta Jealott's Hill International Research Centre, Bracknell, Berkshire, RG42 6EY, UK.
authors.forename: Yucheng
authors.identifier: 0000-0002-6400-6167
authors.initials: Y
authors.lastname: Gu
authors.affiliation: School of Chemistry and Chemical Engineering, Sun Yat-Sen University, 135 Xingang West Road, Guangzhou 510275, China.|Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism (Sun Yat-Sen University), Bureau of Education of Guangdong, Guangzhou, 510275, China.
authors.forename: Lan
authors.identifier: 0000-0003-2765-4015
authors.initials: L
authors.lastname: Liu
authors.affiliation: School of Chemistry and Chemical Engineering, Sun Yat-Sen University, 135 Xingang West Road, Guangzhou 510275, China.|Guangdong Province Key Laboratory of Functional Molecules in Oceanic Microorganism (Sun Yat-Sen University), Bureau of Education of Guangdong, Guangzhou, 510275, China.
authors.forename: Yongcheng
authors.initials: Y
authors.lastname: Lin
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology*; D059001:Aquatic Organisms / Q000302:isolation & purification / Q000378:metabolism*; D032407:Avicennia / Q000382:microbiology; D002851:Chromatography, High Pressure Liquid; D055808:Drug Discovery; D060026:Endophytes / Q000302:isolation & purification / Q000378:metabolism*; D004789:Enzyme Activation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D041621:Eremophila Plant / Q000382:microbiology; D005285:Fermentation; D065089:Glycoside Hydrolase Inhibitors; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009281:Naphthalenes / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D043982:Rhizophoraceae / Q000382:microbiology; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization; D013211:Staphylococcus aureus / Q000187:drug effects; D013098:Xylariales / Q000302:isolation & purification / Q000378:metabolism*; D000520:alpha-Glucosidases / Q000737:chemistry / Q000378:metabolism
chemical_list: C493119:07H239-A; D000900:Anti-Bacterial Agents; D004791:Enzyme Inhibitors; D065089:Glycoside Hydrolase Inhibitors; D009281:Naphthalenes; D012717:Sesquiterpenes; D000520:alpha-Glucosidases