title: Long term effects of the daily wear of senofilcon a silicone hydrogel contact lenses on eyelid tissues.
abstract: OBJECTIVE
  Eyelid changes have been reported with silicone hydrogel contact lenses. It is hypothesized that those changes are associated with the mechanical interaction between the contact lens front surface and eyelid tissues and, are specific to contact lens type rather than a general effect of the lens category. The purpose of this study was to assess the effect of refitting into a silicone hydrogel on a daily wear basis to current contact lens wearers, lapsed wearers and neophytes on eyelid physiology.
  
  
  METHODS
  The investigation was a 2-year prospective investigation of ACUVUE® OASYS® with HYDRACLEAR® Plus (senofilcon A) used with care systems, representative of current practice.
  
  
  RESULTS
  90 subjects were enrolled of whom 64 subjects completed the investigation. The results obtained were as follows:
  
  
  CONCLUSIONS
  The results of the study demonstrated that senofilcon A, worn on a daily wear basis and replaced every 2 weeks, did not produce any eyelid tissue changes in previous non-contact lens wearers at baseline and revealed no change or a slight improvement of the eyelid tissues of established contact lens wearers.
authors.affiliation: OTG Research & Consultancy, London, UK. mguillon@otg.co.uk
authors.forename: Michel
authors.initials: M
authors.lastname: Guillon
authors.forename: Cécile
authors.initials: C
authors.lastname: Maïssa
mesh_terms: D000328:Adult; D003263:Contact Lenses, Hydrophilic / Q000009:adverse effects*; D005141:Eyelid Diseases / Q000209:etiology* / Q000473:pathology; D005143:Eyelids / Q000187:drug effects* / Q000473:pathology; D005260:Female; D006801:Humans; D020100:Hydrogels / Q000009:adverse effects*; D006940:Hyperemia / Q000209:etiology* / Q000473:pathology; D008137:Longitudinal Studies; D008297:Male; D012828:Silicones / Q000009:adverse effects*
chemical_list: D020100:Hydrogels; D012828:Silicones; C523196:senofilcon A