title: [Diagnostic criteria for hypoalphalipoproteinemia and the threshold associated with cardiovascular protection in a Mexican Mestizo population].
abstract: OBJECTIVE
  In the Mexican Mestizo and Indian populations it is unknown the diagnostic criteria (DC) and associated risk of myocardial infarction (MI) for the HDL-cholesterol (HDL-c). We aimed to establish, in a Mexican adult population without cardiovascular risk factors, their HDL-c concentrations, the DC for hypoalphalipoproteinemia and prevalence base on the percentile-10 and the risk associated with MI, as well as the threshold (TH) associated with cardiovascular protection.
  
  
  METHODS
  In 826 adult Mestizos, 98 Indians and 155 Mestizos with MI for the first time the average HDL-c serum concentrations were determined. Then the percentile and statistical analysis were carried out.
  
  
  RESULTS
  The average HDL-c (mg/dl) concentrations for Mestizos and Indians were 43.2 and 37.2 and the ones inferior to the percentile-10 were <30 and <26, respectively. In Mestizos, HDL-c concentrations of ≤ 35 mg/dl (odds ratio [OR] 1.91, 95% confidence interval [95%CI] 1.3-2.8, P=.001) were associated with MI and those >35 (OR 0.52, IC 95% 0.36-0.76, P=.001) were associated with a cardiovascular protection of 52%. The hypoalphalipoproteinemia prevalences in Mestizos and Indians were: for the percentile-10 DC 9 and 11% and for the TH associated with MI ≤ 35, 26 and 54%, respectively.
  
  
  CONCLUSIONS
  The Indians average HDL-c concentration was significantly lower (P<.003) than for Mestizos. The established DC showed that the hypoalphalipoproteinemia prevalences in both populations were similar to those for other open populations. In Mestizos, HDL-c concentrations > 35 mg/dl are protective for MI, but it will be necessary to establish this TH for the Indian population. Each population should establish its own DC for hypoalphalipoproteinemia.
authors.affiliation: Department of Molecular Biomedicine, Centro de Investigación y Estudios Avanzados (CINVESTAV-IPN), México D.F., México.
authors.forename: Daniel
authors.initials: D
authors.lastname: López-Hernández
authors.forename: Alejandra
authors.initials: A
authors.lastname: Meaney-Martínez
authors.forename: Osvaldo E
authors.initials: OE
authors.lastname: Sánchez-Hernández
authors.forename: Eunice
authors.initials: E
authors.lastname: Rodríguez-Arellano
authors.forename: Luis
authors.initials: L
authors.lastname: Beltrán-Lagunes
authors.forename: Teresa
authors.initials: T
authors.lastname: Estrada-García
mesh_terms: D000328:Adult; D008076:Cholesterol, HDL / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D052456:Hypoalphalipoproteinemias / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D007198:Indians, North American; D008297:Male; D008800:Mexico; D009203:Myocardial Infarction / Q000097:blood / Q000517:prevention & control; D015995:Prevalence
chemical_list: D008076:Cholesterol, HDL