title: Proton radiotherapy for solid tumors of childhood.
abstract: The increasing efficacy of pediatric cancer therapy over the past four decades has produced many long-term survivors that now struggle with serious treatment related morbidities affecting their quality of life. Radiation therapy is responsible for a significant proportion of these late effects, but a relatively new and emerging modality, proton radiotherapy hold great promise to drastically reduce these treatment related late effects in long term survivors by sparing dose to normal tissues. Dosimetric studies of proton radiotherapy compared with best available photon based treatment show significant dose sparing to developing normal tissues. Furthermore, clinical data are now emerging that begin to quantify the benefit in decreased late treatment effects while maintaining excellent cancer control rates.
authors.affiliation: Department of Radiation Oncology, Brigham and Women's Hospital and Dana Farber Cancer Institute, Boston, MA 02115, USA.
authors.forename: Shane E
authors.initials: SE
authors.lastname: Cotter
authors.forename: Sean M
authors.initials: SM
authors.lastname: McBride
authors.forename: Torunn I
authors.initials: TI
authors.lastname: Yock
mesh_terms: D002648:Child; D006801:Humans; D009369:Neoplasms / Q000532:radiotherapy*; D059351:Organ Sparing Treatments / Q000379:methods*; D058958:Organs at Risk / Q000528:radiation effects; D061766:Proton Therapy; D011878:Radiotherapy / Q000379:methods*; D011879:Radiotherapy Dosage; D017741:Survivors; D011522:Protons
chemical_list: D011522:Protons