title: Molecular mechanisms of the PRL phosphatases.
abstract: The phosphatases of regenerating liver (PRLs) are an intriguing family of dual specificity phosphatases due to their oncogenicity. The three members are small, single domain enzymes. We provide an overview of the phosphatases of regenerating liver, compare them to related phosphatases, and review recent reports about each phosphatase. Finally, we discuss similarities and differences between the phosphatases of regenerating liver, focusing on their molecular mechanisms and signalling pathways.
authors.affiliation: European Molecular Biology Laboratory, Genome Biology Unit, Heidelberg, Germany.
authors.forename: Pablo
authors.initials: P
authors.lastname: Rios
authors.forename: Xun
authors.initials: X
authors.lastname: Li
authors.forename: Maja
authors.initials: M
authors.lastname: Köhn
mesh_terms: D000595:Amino Acid Sequence; D018797:Cell Cycle Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D017027:Protein Tyrosine Phosphatases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction
chemical_list: D018797:Cell Cycle Proteins; D008565:Membrane Proteins; D009363:Neoplasm Proteins; C490198:PTP4A1 protein, human; C487561:PTP4A2 protein, human; C484730:PTP4A3 protein, human; D017027:Protein Tyrosine Phosphatases