title: Pseudohypoparathyroidism presenting with ventricular arrhythmia: a case report.
abstract: Pseudohypoparathyroidism (PHP) is a rare disorder characterized by varying degrees of unresponsiveness to parathyroid hormone. Patients usually present with hypocalcemia-induced seizures or tetany, whereas no case of hypocalcemia-induced cardiac arrhythmia in PHP has been described to date. In this paper, we report the case of a male adolescent with PHP type 1a who presented with hypocalcemia-induced ventricular extrasystoles (bigeminy, trigeminy) and mild corrected QT interval prolongation. The patient had brachydactyly and his second fingers and toes were longer than the others, a finding consistent with PHP. Laboratory tests detected hypomagnesemia, as well as elevated levels of creatine kinase and lactate dehydrogenase. Ventricular arrhythmia and abnormal laboratory tests improved with calcium supplementation and vitamin D treatment. The findings in this patient suggest that hypomagnesemia may make patients with PHP more susceptible to hypocalcemia and may thus prompt a state of hypocalcemia-induced arrhythmia or other cardiac complications.
authors.affiliation: Gaziantep University Faculty of Medicine, Department of Pediatrics, Gaziantep, Turkey. dr.sedatisikay@hotmail.com
authors.forename: Sedat
authors.initials: S
authors.lastname: Işıkay
authors.forename: İlyas
authors.initials: İ
authors.lastname: Akdemir
authors.forename: Kutluhan
authors.initials: K
authors.lastname: Yılmaz
mesh_terms: D000293:Adolescent; D059327:Brachydactyly / Q000150:complications; D002118:Calcium / Q000627:therapeutic use; D006801:Humans; D006996:Hypocalcemia / Q000150:complications; D008297:Male; D011547:Pseudohypoparathyroidism / Q000150:complications*; D017180:Tachycardia, Ventricular / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D016896:Treatment Outcome; D014807:Vitamin D / Q000627:therapeutic use; D014815:Vitamins / Q000627:therapeutic use
chemical_list: D014815:Vitamins; D014807:Vitamin D; D002118:Calcium