title: Surface-engineered polyelectrolyte multilayer capsules: synthetic vaccines mimicking microbial structure and function.
abstract: Immunizing: to evoke highly potent immune responses against recombinant antigens, hollow capsules consisting of layers of dextran sulphate and poly-L-arginine that encapsulate the antigen ovalbumin (orange circles) were coated with immune-activating CpG-containing oligonucleotides (green). These capsules were readily internalized by dendritic cells and showed activity in further immunization experiments.
authors.affiliation: Laboratory of Pharmaceutical Technology, Department of Pharmaceutics, Ghent University, Belgium. br.degeest@ugent.be
authors.forename: Bruno G
authors.initials: BG
authors.lastname: De Geest
authors.forename: Monique A
authors.initials: MA
authors.lastname: Willart
authors.forename: Bart N
authors.initials: BN
authors.lastname: Lambrecht
authors.forename: Charlotte
authors.initials: C
authors.lastname: Pollard
authors.forename: Chris
authors.initials: C
authors.lastname: Vervaet
authors.forename: Jean Paul
authors.initials: JP
authors.lastname: Remon
authors.forename: Johan
authors.initials: J
authors.lastname: Grooten
authors.forename: Stefaan
authors.initials: S
authors.lastname: De Koker
mesh_terms: D000818:Animals; D002214:Capsules / Q000737:chemistry*; D003713:Dendritic Cells / Q000276:immunology; D016264:Dextran Sulfate / Q000737:chemistry; D004573:Electrolytes / Q000737:chemistry*; D007371:Interferon-gamma / Q000378:metabolism; D051379:Mice; D009838:Oligodeoxyribonucleotides / Q000737:chemistry; D010047:Ovalbumin / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D010455:Peptides / Q000737:chemistry; D011994:Recombinant Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D013499:Surface Properties; D014614:Vaccines, Synthetic / Q000737:chemistry / Q000276:immunology*
chemical_list: C408982:CPG-oligonucleotide; D002214:Capsules; D004573:Electrolytes; D009838:Oligodeoxyribonucleotides; D010455:Peptides; D011994:Recombinant Proteins; D014614:Vaccines, Synthetic; C015462:polyarginine; D007371:Interferon-gamma; D010047:Ovalbumin; D016264:Dextran Sulfate