title: Neuroimaging biomarkers of preterm brain injury: toward developing the preterm connectome.
abstract: For typically developing infants, the last trimester of fetal development extending into the first post-natal months is a period of rapid brain development. Infants who are born premature face significant risk of brain injury (e.g., intraventricular or germinal matrix hemorrhage and periventricular leukomalacia) from complications in the perinatal period and also potential long-term neurodevelopmental disabilities because these early injuries can interrupt normal brain maturation. Neuroimaging has played an important role in the diagnosis and management of the preterm infant. Both cranial US and conventional MRI techniques are useful in diagnostic and prognostic evaluation of preterm brain development and injury. Cranial US is highly sensitive for intraventricular hemorrhage (IVH) and provides prognostic information regarding cerebral palsy. Data are limited regarding the utility of MRI as a routine screening instrument for brain injury for all preterm infants. However, MRI might provide diagnostic or prognostic information regarding PVL and other types of preterm brain injury in the setting of specific clinical indications and risk factors. Further development of advanced MR techniques like volumetric MR imaging, diffusion tensor imaging, metabolic imaging (MR spectroscopy) and functional connectivity are necessary to provide additional insight into the molecular, cellular and systems processes that underlie brain development and outcome in the preterm infant. The adult concept of the "connectome" is also relevant in understanding brain networks that underlie the preterm brain. Knowledge of the preterm connectome will provide a framework for understanding preterm brain function and dysfunction, and potentially even a roadmap for brain plasticity. By combining conventional imaging techniques with more advanced techniques, neuroimaging findings will likely be used not only as diagnostic and prognostic tools, but also as biomarkers for long-term neurodevelopmental outcomes, instruments to assess the efficacy of neuroprotective agents and maneuvers in the NICU, and as screening instruments to appropriately select infants for longitudinal developmental interventions.
authors.affiliation: Department of Radiology, Children's Hospital Los Angeles, Los Angeles, CA, USA. Ashok.Panigrahy@chp.edu
authors.forename: Ashok
authors.initials: A
authors.lastname: Panigrahy
authors.forename: Jessica L
authors.initials: JL
authors.lastname: Wisnowski
authors.forename: Andre
authors.initials: A
authors.lastname: Furtado
authors.forename: Natasha
authors.initials: N
authors.lastname: Lepore
authors.forename: Lisa
authors.initials: L
authors.lastname: Paquette
authors.forename: Stefan
authors.initials: S
authors.lastname: Bluml
mesh_terms: D001720:Birth Injuries / Q000175:diagnosis*; D001930:Brain Injuries / Q000175:diagnosis*; D001931:Brain Mapping / Q000379:methods*; D059907:Functional Neuroimaging / Q000379:methods*; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000175:diagnosis*; D059906:Neuroimaging / Q000379:methods*