title: Slowly progressive lymphohistiocytic meningoencephalomyelitis in 21 adult cats presenting with peculiar neurological signs.
abstract: Twenty-one cats presented with a history of slowly progressive neurological signs characterised by a stiff extended tail, behavioural changes, and spastic and ataxic gait. All cats had outdoor access and lived in the same geographical rural area in north-east Scotland. Histological findings were consistent with lymphohistiocytic meningoencephalomyelitis. Immunohistochemistry ruled out 15 pathogens and showed a significant expression of the interferon-inducible Mx protein, suggesting an as yet unidentified infective or environmental immunogenic trigger as the possible causative agent. The late age at onset (mean 9 years), the very slow progression of clinical signs (mean 11 months) and the peculiar clinical presentation (particularly the posture of the tail) have not been reported previously in cats with lymphohistiocytic meningoencephalomyelitis.
authors.affiliation: Neurology/Neurosurgery Service, Centre for Small Animal Studies, Animal Health Trust, Lanwades Park, Kentford, Suffolk, UK. luisa.derisio@aht.org.uk
authors.forename: Luisa
authors.initials: L
authors.lastname: De Risio
authors.forename: Richard
authors.initials: R
authors.lastname: Brown
authors.forename: Bryn
authors.initials: B
authors.lastname: Tennant
authors.forename: Andy
authors.initials: A
authors.lastname: Sparkes
authors.forename: Lara
authors.initials: L
authors.lastname: Matiasek
authors.forename: Alberta
authors.initials: A
authors.lastname: de Stefani
authors.forename: Herbert
authors.initials: H
authors.lastname: Weissenböck
authors.forename: Kaspar
authors.initials: K
authors.lastname: Matiasek
mesh_terms: D017668:Age of Onset; D000818:Animals; D002371:Cat Diseases / Q000453:epidemiology / Q000473:pathology*; D002415:Cats; D018450:Disease Progression; D004679:Encephalomyelitis / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*; D005260:Female; D020233:Gait Disorders, Neurologic / Q000662:veterinary; D015614:Histiocytosis / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*; D008297:Male; D008590:Meningoencephalitis / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*; D011187:Posture; D012606:Scotland; D013623:Tail