title: Objective evaluation of the correction by non-rigid registration of abdominal organ motion in low-dose 4D dynamic contrast-enhanced CT.
abstract: We objectively evaluate a straightforward registration method for correcting respiration-induced movement of abdominal organs in CT perfusion studies by measuring the distributions of alignment errors between corresponding landmark pairs. We introduce the concept and describe the advantages of using the surface-normal component of distance between pairs of corresponding landmarks selected so that their surface normal is in one of the three coordinate axis directions, and show that such landmarks can be precisely placed with respect to the surface normal. Using a large population of landmark pairs on a substantial quantity of 4D dynamic contrast-enhanced CT volume data, we quantify the average alignment errors of abdominal organs that remain uncorrected by registration.
authors.affiliation: Toshiba Medical Visualization Systems Europe Ltd, Edinburgh, UK.
authors.forename: Jim
authors.initials: J
authors.lastname: Piper
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Ikeda
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Fujisawa
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Ohno
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yoshikawa
authors.forename: Alison
authors.initials: A
authors.lastname: O'Neil
authors.forename: Ian
authors.initials: I
authors.lastname: Poole
mesh_terms: D055592:Biophysical Phenomena; D003287:Contrast Media; D016208:Databases, Factual; D056973:Four-Dimensional Computed Tomography / Q000706:statistics & numerical data*; D006801:Humans; D009068:Movement; D015588:Observer Variation; D011860:Radiography, Abdominal / Q000706:statistics & numerical data
chemical_list: D003287:Contrast Media