title: Bilateral brachial neuritis secondary to varicella reactivation in an HIV-positive man.
abstract: We present the case of a 48-year-old HIV-positive man, who developed acute onset of pain in both upper limbs associated with proximal weakness and distal paraesthesia. Eight weeks prior to this presentation he had had varicella zoster affecting his right S1 dermatome. CD4 count was 355 cells/mm(3) and he was antiretroviral therapy (ART) naive. Power was 0/5 proximally and 4/5 distally in the upper limbs. Reflexes were absent and there was sensory loss in the C5, C6 and T1 dermatomes. Cerebrospinal fluid (CSF) examination showed a lymphocytosis with low glucose; however, CSF Mycobacterium tuberculosis (TB), and herpes simplex virus polymerase chain reaction (HSV PCR) were negative as was syphilis serology. Electromyography showed marked motor axonal loss. Magnetic resonance imaging (MRI) did not show any cervical spinal lesion. Varicella zoster virus (VZV) PCR was positive in the CSF. He was treated with high-dose intravenous aciclovir with good resolution of his syndrome over time and was commenced on ART. We believe this to be the first case report of varicella reactivation causing bilateral neuralgic amyotrophy in an HIV-positive patient.
authors.affiliation: St James's Hospital, Dublin, Ireland. pmcnamara2004@hotmail.com
authors.forename: P
authors.initials: P
authors.lastname: McNamara
authors.forename: B M
authors.initials: BM
authors.lastname: Kiely
authors.forename: S
authors.initials: S
authors.lastname: Zekan
authors.forename: J
authors.initials: J
authors.lastname: Redmond
authors.forename: F
authors.initials: F
authors.lastname: Mulcahy
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D020968:Brachial Plexus Neuritis / Q000503:physiopathology / Q000821:virology*; D002644:Chickenpox / Q000188:drug therapy / Q000473:pathology*; D015658:HIV Infections / Q000473:pathology* / Q000821:virology*; D014645:Herpesvirus 3, Human / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D014775:Virus Activation
chemical_list: D000998:Antiviral Agents; D000212:Acyclovir