title: Subclinical hypothyroidism, mood, and cognition in older adults: a review.
abstract: OBJECTIVE
  To perform a critical review of the literature on the mood and cognitive changes associated with subclinical hypothyroidism (SCH), with an emphasis on older adults. To evaluate these data against the Consensus Statement on the management of SCH from the American Association of Clinical Endocrinologists, the American Thyroid Association, and The Endocrine Society.
  
  
  METHODS
  A comprehensive literature review.
  
  
  RESULTS
  Subclinical hypothyroidism may be associated with an increased risk of mood and cognitive dysfunction, although the strength of this association and the efficacy of replacement hormone therapy require further investigation.
  
  
  CONCLUSIONS
  It remains unclear whether SCH leads to significant mood and cognitive impairments in most older patients. More research is required to determine the nature and extent of this association and whether thyroid hormone replacement therapy is appropriate and effective in treating SCH-associated neurobehavioral impairments.
authors.affiliation: Department of Psychiatry, Staten Island University Hospital, Staten Island, NY 10305, USA. rjoffe51@verizon.net
authors.forename: Russell T
authors.initials: RT
authors.lastname: Joffe
authors.forename: Elizabeth N
authors.initials: EN
authors.lastname: Pearce
authors.forename: James V
authors.initials: JV
authors.lastname: Hennessey
authors.forename: Joseph J
authors.initials: JJ
authors.lastname: Ryan
authors.forename: Robert A
authors.initials: RA
authors.lastname: Stern
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003072:Cognition Disorders / Q000523:psychology*; D032921:Consensus; D020249:Hormone Replacement Therapy; D006801:Humans; D007037:Hypothyroidism / Q000188:drug therapy / Q000523:psychology*; D019964:Mood Disorders / Q000523:psychology*; D013974:Thyroxine / Q000627:therapeutic use
chemical_list: D013974:Thyroxine