title: Trisomy 8 is the most frequent cytogenetic abnormality in de novo myelodysplastic syndrome in China.
abstract: BACKGROUND
  Cytogenetic abnormalities have been detected in 40-60% of patients with de novo myelodysplastic syndrome (MDS). Some reports suggest that Asian and Western MDS patients have different cytogenetic features.
  
  
  METHODS
  We retrospectively analyzed 168 patients with de novo MDS and compared our results with other Chinese centers to investigate the prevalence and cytogenetic characteristics of MDS in China.
  
  
  RESULTS
  In our study, chromosome abnormalities were detected in 40.48% of patients (68/168). Although the median survival time did not differ between younger and older (≥60 years) patients (p = 0.969), survival curves based on International Prognostic Scoring System (IPSS) cytogenetic groups and WHO Classification-Based Prognostic Scoring System (WPSS) risk groups were significantly different (p < 0.001). Survival differences were observed between patients in the normal karyotype group, sole trisomy 8 group, and poor cytogenetic group according to IPSS (p < 0.001). In agreement with the results from 2 other large Chinese centers, trisomy 8 was the most detected cytogenetic abnormality, with a prevalence of 14.21%.
  
  
  CONCLUSIONS
  Trisomy 8, categorized as intermediate cytogenetic risk group in our study, is the most frequent cytogenetic abnormality in de novo MDS in China.
authors.affiliation: Department of Hematology, Tongji Hospital, Wuhan, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Xiao
authors.forename: Jia
authors.initials: J
authors.lastname: Wei
authors.forename: Yan
authors.initials: Y
authors.lastname: Chen
authors.forename: Kejian
authors.initials: K
authors.lastname: Zhang
authors.forename: Jianfeng
authors.initials: J
authors.lastname: Zhou
authors.forename: Yicheng
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000367:Age Factors; D000368:Aged; D044466:Asian People / Q000235:genetics*; D002869:Chromosome Aberrations; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics; D003431:Cross-Cultural Comparison; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000235:genetics* / Q000401:mortality; D012189:Retrospective Studies; D016019:Survival Analysis; D015996:Survival Rate; D014314:Trisomy / Q000235:genetics*