title: Drug delivery observation of hydrophobe ferrofluid and magnetite nanoparticals by SPring-8 synchrotron radiation.
abstract: In this study, the composite magnetic nanoparticles of coated SiO nano film with about 8 nm size and high saturation magnetization value, were synthesized by liquid phase precipitation method. The magnetic nanoparticles can be dispersed in various liquid media, widely known as magnetic fluids or ferrofluids with both magnetic and liquid properties. The materials been collected great interests and more and more attentions to focus into Drug Delivery System (DDS) as a new technology in this paper. We use the composite nanoparticles to disperse H2O and inject the solutions into rat's in-vivo organs. And, in the experiments by using a strong photon beam of SPring-8 Synchrotron Radiation facility, the distribution stat and the effects of magnetic field as well as drug delivery behaviour of nanoparticles in the rat' kidney are verified by the in-vivo observations.
authors.affiliation: Department of Material Science and Engineering, Saitama Institute of Technology, Saitama, 369-0293, Japan.
authors.forename: D Y
authors.initials: DY
authors.lastname: Ju
authors.forename: P
authors.initials: P
authors.lastname: Bian
authors.forename: T
authors.initials: T
authors.lastname: Kumazawa
authors.forename: M
authors.initials: M
authors.lastname: Nakano
authors.forename: H
authors.initials: H
authors.lastname: Matsuura
authors.forename: K
authors.initials: K
authors.lastname: Umetani
authors.forename: T
authors.initials: T
authors.lastname: Komdo
authors.forename: Y
authors.initials: Y
authors.lastname: Uozumi
authors.forename: K
authors.initials: K
authors.lastname: Makino
authors.forename: N
authors.initials: N
authors.lastname: Noda
authors.forename: K
authors.initials: K
authors.lastname: Koide
authors.forename: M
authors.initials: M
authors.lastname: Akutsu
authors.forename: K
authors.initials: K
authors.lastname: Masuyama
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D057927:Hydrophobic and Hydrophilic Interactions; D007668:Kidney / Q000378:metabolism; D060526:Magnetic Fields; D008280:Magnetics / Q000379:methods; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D056004:Molecular Dynamics Simulation; D010087:Oxides / Q000737:chemistry*; D010316:Particle Size; D017785:Photons; D011874:Radiometry / Q000295:instrumentation; D051381:Rats; D012542:Scattering, Radiation; D017655:Silicon Compounds / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*; D012996:Solutions / Q000737:chemistry; D017356:Synchrotrons / Q000295:instrumentation*; D014867:Water / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D058185:Magnetite Nanoparticles; D010087:Oxides; D017655:Silicon Compounds; D012996:Solutions; D014867:Water; C116473:silicon monoxide; D012822:Silicon Dioxide