title: Multifunctional mercapto-tacrine derivatives for treatment of age-related neurodegenerative diseases.
abstract: Cooperating mercapto groups with tacrine in a single molecular, novel multifunctional compounds have been designed and synthesized. These mercapto-tacrine derivatives displayed a synergistic pharmacological profile of long-term potentiation enhancement, cholinesterase inhibition, neuroprotection, and less hepatotoxicity, emerging as promising molecules for the therapy of age-related neurodegenerative diseases.
authors.affiliation: Department of Pharmacology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Wang
authors.forename: Xin-Lei
authors.initials: XL
authors.lastname: Guan
authors.forename: Peng-Fei
authors.initials: PF
authors.lastname: Wu
authors.forename: Can-Ming
authors.initials: CM
authors.lastname: Wang
authors.forename: Hui
authors.initials: H
authors.lastname: Cao
authors.forename: Lei
authors.initials: L
authors.lastname: Li
authors.forename: Xiao-Juan
authors.initials: XJ
authors.lastname: Guo
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.forename: Na
authors.initials: N
authors.lastname: Xie
authors.forename: Feng-Chao
authors.initials: FC
authors.lastname: Jiang
authors.forename: Jian-Guo
authors.initials: JG
authors.lastname: Chen
mesh_terms: D000110:Acetylcholinesterase / Q000737:chemistry; D000375:Aging; D000818:Animals; D002091:Butyrylcholinesterase / Q000737:chemistry; D056547:CA1 Region, Hippocampal / Q000187:drug effects / Q000502:physiology; D045744:Cell Line, Tumor; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D008099:Liver / Q000187:drug effects; D017774:Long-Term Potentiation / Q000187:drug effects; D019636:Neurodegenerative Diseases / Q000188:drug therapy*; D018696:Neuroprotective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013329:Structure-Activity Relationship; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D013619:Tacrine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D002800:Cholinesterase Inhibitors; D018696:Neuroprotective Agents; D013438:Sulfhydryl Compounds; D013619:Tacrine; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase