title: Effects of arterial cannulation stress on regional cerebral blood flow in major depressive disorder.
abstract: Individuals with major depressive disorder (MDD) display abnormal neurophysiological responses to psychological stress but little is known about their neurophysiological responses to physiological stressors. Using [(15)O-H(2)O] positron emission tomography we assessed whether the regional cerebral blood flow (rCBF) response to arterial cannulation differed between patients with MDD and healthy controls (HCs). Fifty-one MDD patients and 62 HCs were scanned following arterial cannulation and 15 MDD patients and 17 HCs were scanned without arterial cannulation. A region-of-interest analysis showed that a significantly increased rCBF of the anterior cingulate cortex and right amygdala was associated with arterial cannulation in MDD. A whole brain analysis showed increased rCBF of the right post-central gyrus, left temporopolar cortex, and right amygdala during arterial cannulation in MDD patients. The rCBF in the right amygdala was significantly correlated with depression severity. Conceivably, the limbic response to invasive physical stress is greater in MDD subjects than in HCs.
authors.affiliation: Section on Neuroimaging in Mood and Anxiety Disorders, Mood and Anxiety Disorders Program, NIH/NIMH, Bethesda, MD. jonathansavitz@hotmail.com
authors.forename: Jonathan
authors.initials: J
authors.lastname: Savitz
authors.forename: Allison C
authors.initials: AC
authors.lastname: Nugent
authors.forename: Dara M
authors.initials: DM
authors.lastname: Cannon
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Carlson
authors.forename: Rebecca
authors.initials: R
authors.lastname: Davis
authors.forename: Alexander
authors.initials: A
authors.lastname: Neumeister
authors.forename: Denise
authors.initials: D
authors.lastname: Rallis-Frutos
authors.forename: Steve
authors.initials: S
authors.lastname: Fromm
authors.forename: Peter
authors.initials: P
authors.lastname: Herscovitch
authors.forename: Wayne C
authors.initials: WC
authors.lastname: Drevets
mesh_terms: D000328:Adult; D002404:Catheterization; D002560:Cerebrovascular Circulation; D003865:Major Depressive Disorder / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography; D012039:Regional Blood Flow