title: Commonest overgrowth syndromes.
abstract: Overgrowth syndromes, although rare, are diagnosed more frequently lately. Major progress, such as the identification of genetic causes, has recently enhanced the delineation of the characteristic and noncharacteristic manifestations, phenotype-genotype correlations and knowledge of the underlying pathophysiologic mechanisms. This review provides a summary of the most important overgrowth syndromes aiming to familiarize the treating physician with the cardinal clinical features involved in these syndromes that encompass overgrowth, but also have a variety of other clinical manifestations (neurologic, musculoskeletal, skin, and accompanying tumors).
authors.affiliation: University of Athens, School of Medicine, Athens, Greece. ekmektzo@hotmail.com
authors.forename: Konstantinos
authors.initials: K
authors.lastname: Ekmektzoglou
authors.forename: Theano
authors.initials: T
authors.lastname: Demestiha
authors.forename: Georgios
authors.initials: G
authors.lastname: Troupis
authors.forename: Theodoros
authors.initials: T
authors.lastname: Xanthos
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics / Q000473:pathology*; D049628:Body Size; D006130:Growth Disorders / Q000151:congenital* / Q000235:genetics / Q000473:pathology; D006801:Humans; D006965:Hyperplasia / Q000151:congenital / Q000235:genetics / Q000473:pathology; D013577:Syndrome