title: Multiple fetal anomalies in association with topiramate and oxcarbezepine treatment.
abstract: We present a case of a woman who used topiramate (100 mg) and oxcarbazepine (300 mg) continuously during pregnancy. Multiple fetal anomalies including limp defects of the lower extremities, pericardiac fluid collection, cardiomegaly, cleft lip and palate, absent right kidney, and dysplastic left kidney were found by ultrasonography. Labor was induced and anomalies were confirmed by autopsy. The malformation rate after exposure to oxcarbazepine in utero as a monotherapy was calculated to be 2.4%, which is compatible with the malformation rate seen in the general population. Topiramate is teratogenic in mice, rats, and rabbits, but there are very few reports about its teratogenicity in humans.
authors.affiliation: Department of Obstetrics and Gynecology, Istanbul University, Cerrahpasa Medical Faculty, Istanbul, Turkey.
authors.forename: Seyfettin
authors.initials: S
authors.lastname: Uludag
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Aydin
authors.forename: Ozlem
authors.initials: O
authors.lastname: Yilmaz
authors.forename: Figen
authors.initials: F
authors.lastname: Aksoy
authors.forename: Dogu
authors.initials: D
authors.lastname: Bakkaloglu
authors.forename: Cihat
authors.initials: C
authors.lastname: Sen
mesh_terms: D000015:Abnormalities, Multiple / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology; D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D002220:Carbamazepine / Q000009:adverse effects / Q000031:analogs & derivatives*; D005260:Female; D005333:Fetus / Q000002:abnormalities*; D005632:Fructose / Q000009:adverse effects / Q000031:analogs & derivatives*; D006801:Humans; D000078330:Oxcarbazepine; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology; D000077236:Topiramate; D016216:Ultrasonography, Prenatal
chemical_list: D000927:Anticonvulsants; D000077236:Topiramate; D005632:Fructose; D002220:Carbamazepine; D000078330:Oxcarbazepine