title: Pimarane diterpenes from the fungus Epicoccum sp. HS-1 associated with Apostichopus japonicus.
abstract: Three new pimarane diterpenes (1, 2 and 3) as well as a known compound 4, were isolated from the marine-derived fungus HS-1 from Apostichopus japonicus. Their structures and relative stereochemistry of 1-3 were elucidated using a combination of NMR spectroscopy and CD. In the primary bioassay, compounds 1, 2 and 4 inhibited the growth of KB and KBv200 with IC(50) of 3.51, 2.34 μg/mL, 20.74, 14.47 μg/mL, and 3.86, 6.52 μg/mL, respectively.
authors.affiliation: Key Laboratory for Applied Microbiology of Shandong Province, Biotechnology Center of Shandong Academy of Sciences, Jinan 250014, PR China.
authors.forename: Xuekui
authors.initials: X
authors.lastname: Xia
authors.forename: Jianye
authors.initials: J
authors.lastname: Zhang
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Zhang
authors.forename: Fang
authors.initials: F
authors.lastname: Wei
authors.forename: Xin
authors.initials: X
authors.lastname: Liu
authors.forename: Airong
authors.initials: A
authors.lastname: Jia
authors.forename: Changheng
authors.initials: C
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Li
authors.forename: Zhigang
authors.initials: Z
authors.lastname: She
authors.forename: Yongcheng
authors.initials: Y
authors.lastname: Lin
mesh_terms: D045784:Abietanes / Q000737:chemistry* / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002942:Circular Dichroism; D002945:Cisplatin / Q000737:chemistry / Q000494:pharmacology; D005658:Fungi / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D008386:Marine Biology; D015394:Molecular Structure; D047528:Stichopus / Q000382:microbiology*
chemical_list: D045784:Abietanes; D000970:Antineoplastic Agents; D002945:Cisplatin