title: Design and synthesis of novel magnolol derivatives as potential antimicrobial and antiproliferative compounds.
abstract: A series of novel magnolol derivatives were synthesised and evaluated for in vitro antimicrobial and antiproliferative activities. We found that most of the compounds were effective inhibitors of Staphylococcus aureus, MRSA and VRE with MIC in the range of 1-64 μg/mL and MBC in the range of 1-128 μg/mL. Few derivatives also exhibited promising antifungal activity. Some magnolol analogues exhibited promising antiproliferative activity than parent magnolol when tested against three human cancer cell lines.
authors.affiliation: Organic Division-I, Indian Institute of Chemical Technology, Hyderabad 500007, India.
authors.forename: Srinivas
authors.initials: S
authors.lastname: Jada
authors.forename: Mahendhar Reddy
authors.initials: MR
authors.lastname: Doma
authors.forename: Parvinder Pal
authors.initials: PP
authors.lastname: Singh
authors.forename: Suresh
authors.initials: S
authors.lastname: Kumar
authors.forename: Fayaz
authors.initials: F
authors.lastname: Malik
authors.forename: Akash
authors.initials: A
authors.lastname: Sharma
authors.forename: Inshad Ali
authors.initials: IA
authors.lastname: Khan
authors.forename: G N
authors.initials: GN
authors.lastname: Qazi
authors.forename: H M Sampath
authors.initials: HM
authors.lastname: Kumar
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001688:Biological Products / Q000737:chemistry; D001713:Biphenyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D060326:Chemistry Techniques, Synthetic; D053938:DNA Fragmentation / Q000187:drug effects; D015195:Drug Design; D006801:Humans; D017705:Lignans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D000935:Antifungal Agents; D000970:Antineoplastic Agents; D001688:Biological Products; D001713:Biphenyl Compounds; D017705:Lignans; C005498:magnolol