title: Emergence of cytomegalovirus resistance to foscarnet in a patient receiving foscarnet salvage therapy for multidrug-resistant HIV infection.
abstract: Foscarnet (FOS) is a pyrophosphate analogue that inhibits both cytomegalovirus (CMV) and human immunodeficiency virus (HIV) replication. We describe herein the emergence of CMV resistance to FOS in a 54-year-old man receiving FOS salvage therapy because of multidrug-resistant HIV-1 infection. Oral valganciclovir (VGCV) treatment allowed subsequently the improvement of FOS-resistant CMV infection.
authors.affiliation: UPMC Univ Paris 06, ER1 DETIV, F-75013 Paris, France. david.boutolleau@psl.aphp.fr
authors.forename: David
authors.initials: D
authors.lastname: Boutolleau
authors.forename: Ana
authors.initials: A
authors.lastname: Canestri
authors.forename: Sonia
authors.initials: S
authors.lastname: Burrel
authors.forename: Marc
authors.initials: M
authors.lastname: Wirden
authors.forename: Sophie
authors.initials: S
authors.lastname: Seang
authors.forename: Cyril
authors.initials: C
authors.lastname: Clavel-Osorio
authors.forename: Anne-Geneviève
authors.initials: AG
authors.lastname: Marcelin
authors.forename: Christine
authors.initials: C
authors.lastname: Katlama
authors.forename: Henri
authors.initials: H
authors.lastname: Agut
mesh_terms: D023241:Antiretroviral Therapy, Highly Active / Q000379:methods; D000998:Antiviral Agents / Q000494:pharmacology*; D003587:Cytomegalovirus / Q000187:drug effects*; D003586:Cytomegalovirus Infections / Q000150:complications / Q000821:virology*; D024921:Drug Resistance, Multiple, Viral; D024882:Drug Resistance, Viral; D017245:Foscarnet / Q000494:pharmacology*; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy*; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D016879:Salvage Therapy / Q000379:methods
chemical_list: D000998:Antiviral Agents; D017245:Foscarnet