title: Insulin-like growth factors and insulin: at the crossroad between tumor development and longevity.
abstract: Numerous lines of evidence indicate that insulin-like growth factor signaling plays an important role in the regulation of life span and tumor development. In the present paper, the role of individual components of insulin-like growth factor signaling in aging and tumor development has been extensively analyzed. The molecular mechanisms underlying aging and tumor development are frequently overlapping. Although the link between reduced insulin-like growth factor signaling and suppressed tumor growth and development is well established, it remains unclear whether extended life span results from direct suppression of insulin-like growth factor signaling or this effect is caused by indirect mechanisms such as improved insulin sensitivity.
authors.affiliation: Department of Cell Biology, Imclone Systems, a wholly owned subsidiary of Eli Lilly & Co, New York, USA.
authors.forename: Ruslan
authors.initials: R
authors.lastname: Novosyadlyy
authors.forename: Derek
authors.initials: D
authors.lastname: Leroith
mesh_terms: D000375:Aging / Q000378:metabolism; D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000378:metabolism; D005260:Female; D051858:Forkhead Transcription Factors / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance / Q000502:physiology; D008136:Longevity / Q000502:physiology; D020935:MAP Kinase Signaling System / Q000502:physiology; D008297:Male; D051379:Mice; D016328:NF-kappa B / Q000378:metabolism; D051381:Rats; D011972:Receptor, Insulin / Q000378:metabolism; D013002:Somatomedins / Q000378:metabolism*
chemical_list: D051858:Forkhead Transcription Factors; D007328:Insulin; D016328:NF-kappa B; D013002:Somatomedins; D011972:Receptor, Insulin