title: Biocatalytic hydroxylation of n-butane with in situ cofactor regeneration at low temperature and under normal pressure.
abstract: The hydroxylation of n-alkanes, which proceeds in the presence of a P450-monooxygenase advantageously at temperatures significantly below room temperature, is described. In addition, an enzymatic hydroxylation of the "liquid gas" n-butane with in situ cofactor regeneration, which does not require high-pressure conditions, was developed. The resulting 2-butanol was obtained as the only regioisomer, at a product concentration of 0.16 g/L.
authors.affiliation: Department of Chemistry and Pharmacy, University of Erlangen-Nürnberg, Henkestr. 42, 91054 Erlangen, Germany.
authors.forename: Svenja
authors.initials: S
authors.lastname: Staudt
authors.forename: Christina A
authors.initials: CA
authors.lastname: Müller
authors.forename: Jan
authors.initials: J
authors.lastname: Marienhagen
authors.forename: Christian
authors.initials: C
authors.lastname: Böing
authors.forename: Stefan
authors.initials: S
authors.lastname: Buchholz
authors.forename: Ulrich
authors.initials: U
authors.lastname: Schwaneberg
authors.forename: Harald
authors.initials: H
authors.lastname: Gröger