title: Argutalactone, an unprecedented sesquiterpenoid lactone with a 6/5/7 tricyclic system from Incarvillea arguta.
abstract: Argutalactone (1), a novel sesquiterpenoid lactone featuring an unprecedented 6/5/7 rigid skeleton, was isolated from the roots of Incarvillea arguta. The structure and relative configuration of 1 were established by extensive analysis of spectroscopic data. The absolute configuration of 1 was determined as 2R,5S,10R,12S based on the analysis of biogenetical transformation, comparison of the optical rotation with literature data, and comparison of the experimental circular dichroism spectrum with the calculated electronic circular dichroism spectra.
authors.affiliation: Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Fu
authors.forename: Li-Yan
authors.initials: LY
authors.lastname: Wang
authors.forename: Hong-Lin
authors.initials: HL
authors.lastname: Li
authors.forename: Jiang-Jiang
authors.initials: JJ
authors.lastname: Qin
authors.forename: Yun-Heng
authors.initials: YH
authors.lastname: Shen
authors.forename: Jia-Gao
authors.initials: JG
authors.lastname: Cheng
authors.forename: Hui-Zi
authors.initials: HZ
authors.lastname: Jin
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Zhang
mesh_terms: D029402:Bignoniaceae / Q000737:chemistry*; D002942:Circular Dichroism; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000302:isolation & purification*; D007783:Lactones / Q000737:chemistry* / Q000302:isolation & purification*; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification*; D013237:Stereoisomerism
chemical_list: D004365:Drugs, Chinese Herbal; D007783:Lactones; D012717:Sesquiterpenes; C573378:argutalactone