title: Comparative evaluation of the efficacy of three commercially available toothpastes on dentin hypersensitivity reduction: an eight-week clinical study.
abstract: OBJECTIVE
  The objective of this eight-week, single-center, three-cell, double-blind, and randomized clinical study was to evaluate the dentin hypersensitivity reduction efficacy of three commercially available toothpastes: 1) Colgate Sensitive Pro-Relief Toothpaste (also marketed as elmex Sensitive Professional); 2) Sensodyne Rapid Relief Toothpaste; and (3) Crest Cavity Protection Toothpaste.
  
  
  METHODS
  150 subjects, having two teeth with tactile and air blast hypersensitivity, were assigned to one of the three study groups (50/group). Subjects were then asked to brush their teeth for one minute, twice daily, with the given toothpaste. The dentin hypersensitivity and oral tissues were evaluated at baseline, two weeks, four weeks, and eight weeks. Comparison of the treatment groups with respect to gender was conducted using a chi-square analysis, and with respect to age and baseline hypersensitivity scores was performed using the analysis of variance (ANOVA). Within-treatment effects were analyzed using the paired t-test, while the analysis of covariance (ANCOVA) was used to examine between-treatment effects. The post hoc Tukey test was performed for pair-wise comparisons. All statistical tests were two-sided using a significance level of alpha = 0.05.
  
  
  RESULTS
  After two, four, and eight weeks of daily use of the products, all three groups showed a statistically significant reduction from baseline in tactile and air blast dentin hypersensitivity (p < 0.05). Colgate Sensitive Pro-Relief toothpaste produced a significant improvement in mean tactile and air blast dentin hypersensitivity scores, and was more effective than Sensodyne Rapid Relief toothpaste and Crest Cavity Protection toothpastes (p < 0.05).
  
  
  CONCLUSIONS
  Colgate Sensitive Pro-ReliefToothpaste, used twice daily, significantly reduces dentin hypersensitivity, and is significantly more effective in reducing dentin hypersensitivity than Sensodyne Rapid Relief Toothpaste and Crest Cavity Protection Toothpaste.
authors.affiliation: University of Rome at Tor Vergata, Rome, Italy.
authors.forename: Raffaella
authors.initials: R
authors.lastname: Docimo
authors.forename: Cesare
authors.initials: C
authors.lastname: Perugia
authors.forename: Martina
authors.initials: M
authors.lastname: Bartolino
authors.forename: Paolo
authors.initials: P
authors.lastname: Maturo
authors.forename: Luigi
authors.initials: L
authors.lastname: Montesani
authors.forename: Yun Po
authors.initials: YP
authors.lastname: Zhang
authors.forename: William
authors.initials: W
authors.lastname: DeVizio
authors.forename: Luis R
authors.initials: LR
authors.lastname: Mateo
authors.forename: Serge
authors.initials: S
authors.lastname: Dibart
mesh_terms: D000085:Acetates / Q000008:administration & dosage / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000388:Air; D001120:Arginine / Q000008:administration & dosage / Q000627:therapeutic use; D002119:Calcium Carbonate / Q000008:administration & dosage / Q000627:therapeutic use; D057133:Dentin Desensitizing Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D003807:Dentin Sensitivity / Q000517:prevention & control*; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D005459:Fluorides / Q000008:administration & dosage / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010710:Phosphates / Q000008:administration & dosage / Q000627:therapeutic use; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000627:therapeutic use; D013324:Strontium / Q000008:administration & dosage / Q000627:therapeutic use; D014099:Toothbrushing / Q000379:methods; D014100:Toothpastes / Q000627:therapeutic use*; D014110:Touch; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000085:Acetates; D057133:Dentin Desensitizing Agents; D004338:Drug Combinations; D010710:Phosphates; D014100:Toothpastes; C012980:fluorophosphate; C106741:strontium acetate; D012969:Sodium Fluoride; D001120:Arginine; D002119:Calcium Carbonate; D005459:Fluorides; D013324:Strontium