title: Rare human skin infection with Corynebacterium ulcerans: transmission by a domestic cat.
abstract: Corynebacterium ulcerans is mainly known for its ability to cause animal infections. Some strains of C. ulcerans produce diphtheria toxin, which can cause life-threatening cardiopathies and neuropathies in humans. Human cutaneous C. ulcerans infection is a very rare disease that mimics classical cutaneous diphtheria. We present a very rare case of a C. ulcerans skin infection caused by a non-diphtheria toxin-producing strain of C. ulcerans that resolved after 3 weeks of therapy with amoxicillin-clavulanate. A pet cat was the probable source of infection. The presence of C. ulcerans in the mouth of the cat was confirmed by 16S rRNA gene analysis and the API Coryne system. In cases of human infection with potentially toxigenic corynebacteria, it is important to determine the species and examine the isolate for diphtheria toxin production. If toxigenicity is present, diphtheria antitoxin should be administered immediately. Carriers and potential infectious sources of C. ulcerans include not only domestic livestock but also pet animals. For the primary prevention of disease caused by diphtheria toxin-producing corynebacteria, vaccination with diphtheria toxoid is recommended.
authors.affiliation: Outpatient Clinic of Dermatology, Triemli Hospital, Zurich, Switzerland.
authors.forename: M A M
authors.initials: MA
authors.lastname: Corti
authors.forename: G V
authors.initials: GV
authors.lastname: Bloemberg
authors.forename: S
authors.initials: S
authors.lastname: Borelli
authors.forename: H
authors.initials: H
authors.lastname: Kutzner
authors.forename: G
authors.initials: G
authors.lastname: Eich
authors.forename: L
authors.initials: L
authors.lastname: Hoelzle
authors.forename: S
authors.initials: S
authors.lastname: Lautenschlager
mesh_terms: D000328:Adult; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002371:Cat Diseases / Q000382:microbiology / Q000635:transmission*; D002415:Cats; D003352:Corynebacterium / Q000235:genetics / Q000302:isolation & purification*; D003354:Corynebacterium Infections / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology / Q000635:transmission*; D006225:Hand / Q000382:microbiology / Q000473:pathology; D006801:Humans; D008297:Male; D057805:Pets / Q000382:microbiology*; D017192:Skin Diseases, Bacterial / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology / Q000635:transmission*; D015047:Zoonoses / Q000382:microbiology / Q000635:transmission*
chemical_list: D000900:Anti-Bacterial Agents