title: Prevention and management of central line-associated bloodstream infections in hospital practice.
abstract: In this article aimed at hospitalists, we examine the literature on preventive measures for central line-associated bloodstream infections (CLABSIs) and optimal management once a CLABSI has been established. We focus on a number of core preventive measures and the contemporary approach of bundling these measures for maximal impact in reducing infection rates. We then discuss empiric and pathogen-specific antibiotic therapy, including the role of newer antimicrobial agents, as well as the management of an infected central venous catheter.
authors.affiliation: Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110-1093, USA.
authors.forename: Stephen Y
authors.initials: SY
authors.lastname: Liang
authors.forename: Hani
authors.initials: H
authors.lastname: Khair
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Durkin
authors.forename: Jonas
authors.initials: J
authors.lastname: Marschall
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D016470:Bacteremia / Q000517:prevention & control; D055499:Catheter-Related Infections / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology / Q000517:prevention & control*; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D002408:Catheters, Indwelling / Q000009:adverse effects* / Q000382:microbiology; D006235:Hand Disinfection; D006801:Humans; D017053:Infection Control / Q000379:methods; D007318:Inservice Training / Q000379:methods
chemical_list: D000900:Anti-Bacterial Agents