title: Propofol attenuates ischemic reperfusion-induced formation of lipid peroxides in liver transplant recipients.
abstract: OBJECTIVE
  Ischemic reperfusion (IR) injury is known to have an important influence on the success of transplant surgery and the occurrence of complications. Malondialdehyde (MDA) is an intermediate metabolite of lipid peroxidation resulting from IR-induced reactive oxygen species. This study was designed to investigate the protective effects of propofol on IR injury in liver transplant recipients.
  
  
  METHODS
  We analyzed 19 recipients prospectively by measuring the blood levels of MDA at nine predefined intervals; before induction of anesthesia (baseline, T0), 1 hour after surgical incision (T1), 1 minute before reperfusion (T2), 30 seconds after reperfusion (T3), as well as 1, 3, 5, 30, and 60 minutes thereafter (T4-8). These patients were randomly allocated to two groups. The propofol group received an infusion (2 mg/kg per hr) after an induction bolus (2 mg/kg). The control group was prescribed midazolam (0.2 mg/kg) for induction without intravenous anesthetic infusion for maintenance.
  
  
  RESULTS
  The highest MDA level occured at T6 in the controls and T7 in the propofol group. Compared with the blood levels at baseline, the MDA levels increased significantly at T2-T8 among controls versus T2, T3, T4, and T7 in the propofol group. Compared to the control group, propofol significantly lowered MDA values at T5-T8.
  
  
  CONCLUSIONS
  There were significantly higher MDA levels among the control versus the propofol group at 3, 5, 30, and 60 minutes after reperfusion in liver transplant recipients.
authors.affiliation: Department of Anesthesiology, College of Medicine, Graduate Institute of Clinical Medical Sciences, and Department of General Surgery, Chang Gung Memorial Hospital, Tao-Yuan, Taiwan.
authors.forename: Y-F
authors.initials: YF
authors.lastname: Tsai
authors.forename: C-C
authors.initials: CC
authors.lastname: Lin
authors.forename: W-C
authors.initials: WC
authors.lastname: Lee
authors.forename: H-P
authors.initials: HP
authors.lastname: Yu
mesh_terms: D000328:Adult; D018686:Anesthetics, Intravenous / Q000008:administration & dosage*; D015415:Biomarkers / Q000097:blood; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D008054:Lipid Peroxides / Q000378:metabolism*; D016031:Liver Transplantation / Q000009:adverse effects*; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D015742:Propofol / Q000008:administration & dosage*; D011446:Prospective Studies; D015424:Reperfusion / Q000009:adverse effects*; D015427:Reperfusion Injury / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D013624:Taiwan; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D018686:Anesthetics, Intravenous; D015415:Biomarkers; D008054:Lipid Peroxides; D008315:Malondialdehyde; D015742:Propofol