title: [Changes in mRNA and protein expression of antioxidant enzymes in children with bronchial asthma after interval hypoxic training].
abstract: The effect of 10 days of interval hypoxic training (IHT) on the mRNA expression and protein content of antioxidant enzymes (superoxide dismutase, catalase and glutathione-S-transferase) in leukocytes of children with bronchial asthma (BA) was investigated. It was shown that after sessions of IHT the mRNA expression of superoxide dismutase decreased by 32.5% (P < 0,05), but the level of protein was unchanged. The level of catalase gene mRNA and protein content in leukocytes after IHT increased by 67% and 13% accordingly. We detected a 90% increase in glutathione S-transferase level following IHT.
authors.forename: K V
authors.initials: KV
authors.lastname: Nesvitaĭlova
authors.forename: O O
authors.initials: OO
authors.lastname: Honchar
authors.forename: T I
authors.initials: TI
authors.lastname: Drevyts'ka
authors.forename: L P
authors.initials: LP
authors.lastname: Arabs'ka
authors.forename: M M
authors.initials: MM
authors.lastname: Steshenko
authors.forename: O M
authors.initials: OM
authors.lastname: Bakunovs'kyĭ
authors.forename: T V
authors.initials: TV
authors.lastname: Serebrovs'ka
authors.forename: I M
authors.initials: IM
authors.lastname: Man'kovs'ka
mesh_terms: D000222:Adaptation, Physiological / Q000502:physiology*; D000293:Adolescent; D000975:Antioxidants / Q000378:metabolism*; D001249:Asthma / Q000097:blood / Q000201:enzymology / Q000503:physiopathology / Q000628:therapy*; D002374:Catalase / Q000096:biosynthesis / Q000235:genetics; D002648:Child; D005260:Female; D015870:Gene Expression; D005982:Glutathione Transferase / Q000096:biosynthesis / Q000235:genetics; D006801:Humans; D000860:Hypoxia / Q000201:enzymology / Q000503:physiopathology*; D007962:Leukocytes / Q000201:enzymology; D008297:Male; D012333:RNA, Messenger / Q000096:biosynthesis* / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013482:Superoxide Dismutase / Q000096:biosynthesis / Q000235:genetics; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants; D012333:RNA, Messenger; D002374:Catalase; D013482:Superoxide Dismutase; D005982:Glutathione Transferase