title: Total syntheses of the elusive welwitindolinones with bicyclo[4.3.1] cores.
abstract: The welwitindolinones with bicyclo[4.3.1] cores are a class of natural products that have attracted tremendous interest from the synthetic community because of their fascinating structures and promising biological profiles. More than 15 research groups worldwide have reported progress toward these elusive natural products. This Minireview describes contemporary studies aimed at the total synthesis of these challenging targets, in addition to the two recently completed syntheses of welwitindolinones with bicyclo[4.3.1] cores reported by Rawal and Garg in 2011. Both of the completed efforts rely on C4-C11 bond constructions to access the congested bicyclic framework of these elusive natural products.
authors.affiliation: Department of Chemistry and Biochemistry, University of California, Los Angeles, 90095, USA.
authors.forename: Alexander D
authors.initials: AD
authors.lastname: Huters
authors.forename: Evan D
authors.initials: ED
authors.lastname: Styduhar
authors.forename: Neil K
authors.initials: NK
authors.lastname: Garg
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis* / Q000737:chemistry; D001643:Bridged Bicyclo Compounds / Q000737:chemistry*; D002384:Catalysis; D026121:Indole Alkaloids / Q000138:chemical synthesis / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry; D012238:Rhodium / Q000737:chemistry
chemical_list: D001688:Biological Products; D001643:Bridged Bicyclo Compounds; D026121:Indole Alkaloids; C092270:welwitindolinone C isothiocyanate; D010165:Palladium; D012238:Rhodium