title: Dorsoventral differences in intrinsic properties in developing CA1 pyramidal cells.
abstract: The dorsoventral and developmental gradients of entorhinal layer II cell grid properties correlate with their resonance properties and with their hyperpolarization-activated cyclic nucleotide-gated (HCN) ion channel current characteristics. We investigated whether such correlation existed in rat hippocampal CA1 pyramidal cells, where place fields also show spatial and temporal gradients. Resonance was absent during the first postnatal week, and emerged during the second week. Resonance was stronger in dorsal than ventral cells, in accord with HCN current properties. Resonance responded to cAMP in ventral but not in dorsal cells. The dorsoventral distribution of HCN1 and HCN2 subunits and of the auxiliary protein tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b) could account for these differences between dorsal and ventral cells. The analogous distribution of the intrinsic properties of entorhinal stellate and hippocampal cells suggests the existence of general rules of organization among structures that process complementary features of the environment.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM), UMR 1106, Marseille, F-13385 France.
authors.forename: Béatrice
authors.initials: B
authors.lastname: Marcelin
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Liu
authors.forename: Yuncai
authors.initials: Y
authors.lastname: Chen
authors.forename: Alan S
authors.initials: AS
authors.lastname: Lewis
authors.forename: Albert
authors.initials: A
authors.lastname: Becker
authors.forename: Shawn
authors.initials: S
authors.lastname: McClelland
authors.forename: Dane M
authors.initials: DM
authors.lastname: Chetkovich
authors.forename: Michele
authors.initials: M
authors.lastname: Migliore
authors.forename: Tallie Z
authors.initials: TZ
authors.lastname: Baram
authors.forename: Monique
authors.initials: M
authors.lastname: Esclapez
authors.forename: Christophe
authors.initials: C
authors.lastname: Bernard
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D056547:CA1 Region, Hippocampal / Q000166:cytology* / Q000254:growth & development*; D008297:Male; D009924:Organ Culture Techniques; D017966:Pyramidal Cells / Q000166:cytology* / Q000254:growth & development*; D051381:Rats; D017208:Rats, Wistar