title: Association of a SLC30A8 genetic variant with monotherapy of repaglinide and rosiglitazone effect in newly diagnosed type 2 diabetes patients in China.
abstract: OBJECTIVE
  To investigate a potential relationship between Solute carrier family 30 (zinc transporter) member 8 (SLC30A8) rs13266634 variant and efficacy of rosiglitazone or repaglinide in treating newly diagnosed Chinese type 2 diabetes patients.
  
  
  METHODS
  A total of 209 diabetic patients without any antihyperglycemic history were recruited and treated with repaglinide or rosiglitazone randomly for 48 weeks (104 and 105 patients, respectively). Anthropometric measurements and clinical laboratory tests were carried out before and after the treatment. An non-synonymous variant rs13266634 was genotyped by matrix-assisted laser desorption ionization-time of flight mass spectroscopy.
  
  
  RESULTS
  Ninety-one patients in repaglinide group and ninety-three patients in rosiglitazone group completed the study. Δ value of homeostasis model assessment of beta cell function (HOMA-B) and Δ value of fasting proinsulin levels were statistically significant between three genotype groups (P=0.0149 and 0.0246, respectively) after rosiglitazone treatment. However, no genotype association was observed in the repaglinide or rosiglitazone group with other parameters.
  
  
  CONCLUSIONS
  The SLC30A8 variant was associated with the efficacy of insulin sensitizer monotherapy on insulin secretion in patients with newly diagnosed type 2 diabetes mellitus in Shanghai, China.
authors.affiliation: Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
authors.forename: Feng
authors.initials: F
authors.lastname: Jiang
authors.forename: Qing
authors.initials: Q
authors.lastname: Li
authors.forename: Cheng
authors.initials: C
authors.lastname: Hu
authors.forename: Rong
authors.initials: R
authors.lastname: Zhang
authors.forename: Cong Rong
authors.initials: CR
authors.lastname: Wang
authors.forename: Wei Hui
authors.initials: WH
authors.lastname: Yu
authors.forename: Jing Yi
authors.initials: JY
authors.lastname: Lu
authors.forename: Shan Shan
authors.initials: SS
authors.lastname: Tang
authors.forename: Yu Qian
authors.initials: YQ
authors.lastname: Bao
authors.forename: Kun San
authors.initials: KS
authors.lastname: Xiang
authors.forename: Wei Ping
authors.initials: WP
authors.lastname: Jia
mesh_terms: D002219:Carbamates / Q000627:therapeutic use*; D027682:Cation Transport Proteins / Q000235:genetics*; D002681:China; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000627:therapeutic use*; D020641:Polymorphism, Single Nucleotide; D000077154:Rosiglitazone; D045162:Thiazolidinediones / Q000627:therapeutic use*; D000075703:Zinc Transporter 8
chemical_list: D002219:Carbamates; D027682:Cation Transport Proteins; D007004:Hypoglycemic Agents; D010880:Piperidines; C492522:SLC30A8 protein, human; D045162:Thiazolidinediones; D000075703:Zinc Transporter 8; D000077154:Rosiglitazone; C072379:repaglinide