title: Metabolic syndrome decreases tissue perfusion and induces glandular hyperplasia in the fructose-fed rat prostate.
abstract: OBJECTIVE
  The effects of metabolic syndrome on the prostate blood perfusion and histological structure were studied using fructose-fed rats (FR).
  
  
  METHODS
  Age-matched male Wistar rats were divided into two groups: group I, normal control rats and group II, 9-week FR. Animal body weight, blood pressure, and serum metabolic parameters were monitored. With the rats under anesthesia, prostatic blood flow volume and flow velocity were measured by laser Doppler flowmetry. The prostate was then removed for histological examination and morphometric study.
  
  
  RESULTS
  The 9-week FR showed significant increases in body weight, blood pressure, plasma glucose, insulin, and triglyceride levels. The blood flow volume (345.8 ± 20.57 ml/min/100 g vs. 440.4 ± 35.57 ml/min/100 g of tissue, P < 0.05 for n = 8) and flow rate (29.4 ± 1.25 units vs. 40.9 ± 2.65 units, P < 0.05 for n = 8) in the FR ventral prostate were significantly decreased when compared to controls. Structurally, the FR prostate weight was significantly higher than that of the controls (612.4 ± 16.9 mg vs. 427.3 ± 6.5 mg, P < 0.05 for n = 8). Prostate histology showed glandular hyperplasia while morphometry showed increased stromal component in the FR.
  
  
  CONCLUSIONS
  Metabolic syndrome in the FR decreases prostatic perfusion and induces prostatic glandular hyperplasia. The findings suggest that chronic ischemia may be a link between metabolic syndrome and prostatic enlargement.
authors.affiliation: Graduate Institute of Clinical Research, National Cheng Kung University, Tainan, Taiwan.
authors.forename: I-Hung
authors.initials: IH
authors.lastname: Chen
authors.forename: Yat-Ching
authors.initials: YC
authors.lastname: Tong
authors.forename: Juei-Tang
authors.initials: JT
authors.lastname: Cheng
mesh_terms: D000818:Animals; D001786:Blood Glucose; D001835:Body Weight / Q000187:drug effects; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D005632:Fructose / Q000008:administration & dosage*; D008297:Male; D024821:Metabolic Syndrome / Q000139:chemically induced / Q000473:pathology*; D011467:Prostate / Q000098:blood supply / Q000473:pathology*; D011470:Prostatic Hyperplasia / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001786:Blood Glucose; D004040:Dietary Carbohydrates; D005632:Fructose