title: The axonal guidance receptor neogenin promotes acute inflammation.
abstract: Neuronal guidance proteins (NGP) were originally described in the context of axonal growth and migration. Yet recent work has demonstrated that NGPs also serve as guidance cues for immune competent cells. A crucial target receptor for NGPs during embryonic development is the neogenin receptor, however its role during acute inflammation is unknown. We report here that neogenin is abundantly expressed outside the nervous system and that animals with endogenous repression of neogenin (Neo1(-/-)) demonstrate attenuated changes of acute inflammation. Studies using functional inhibition of neogenin resulted in a significant attenuation of inflammatory peritonitis. In studies employing bone marrow chimeric animals we found the hematopoietic presence of Neo1(-/-) to be responsible for the attenuated inflammatory response. Taken together our studies suggest that the guidance receptor neogenin holds crucial importance for the propagation of an acute inflammatory response and further define mechanisms shared between the nervous and the immune system.
authors.affiliation: Department of Anesthesiology and Intensive Care Medicine, Tübingen University Hospital, Eberhard-Karls University Tübingen, Tübingen, Germany.
authors.forename: Klemens
authors.initials: K
authors.lastname: König
authors.forename: Dimitra
authors.initials: D
authors.lastname: Gatidou
authors.forename: Tiago
authors.initials: T
authors.lastname: Granja
authors.forename: Jens
authors.initials: J
authors.lastname: Meier
authors.forename: Peter
authors.initials: P
authors.lastname: Rosenberger
authors.forename: Valbona
authors.initials: V
authors.lastname: Mirakaj
mesh_terms: D000818:Animals; D016207:Cytokines / Q000378:metabolism; D015870:Gene Expression; D007249:Inflammation / Q000235:genetics / Q000378:metabolism*; D018836:Inflammation Mediators / Q000378:metabolism; D008297:Male; D008565:Membrane Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D018345:Mice, Knockout; D009928:Organ Specificity / Q000235:genetics; D010538:Peritonitis / Q000235:genetics / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism*
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators; D008565:Membrane Proteins; D011956:Receptors, Cell Surface; C091279:neogenin