title: Polystyrene-supported (2S)-(-)-3-exo-piperazinoisoborneol: an efficient catalyst for the batch and continuous flow production of enantiopure alcohols.
abstract: A polystyrene-supported analog (PS-PIB) of 3-exo-morpholinoisoborneol (MIB), designed for increased chemical stability, has been synthesized and used as a ligand in the asymmetric alkylation of aldehydes with Et(2)Zn. The supported ligand turned out to be highly active and enantioselective for a broad scope of substrates (92-99% ee), allowing repeated recycling. A single-pass, continuous flow process implemented with PS-PIB shows only a marginal decrease in conversion after 30 h of operation.
authors.affiliation: Institute of Chemical Research of Catalonia, Av. Països Catalans, 16, E-43007 Tarragona, Spain.
authors.forename: Laura
authors.initials: L
authors.lastname: Osorio-Planes
authors.forename: Carles
authors.initials: C
authors.lastname: Rodríguez-Escrich
authors.forename: Miquel A
authors.initials: MA
authors.lastname: Pericàs