title: FAT SIGNALS--lipases and lipolysis in lipid metabolism and signaling.
abstract: Lipolysis is defined as the catabolism of triacylglycerols stored in cellular lipid droplets. Recent discoveries of essential lipolytic enzymes and characterization of numerous regulatory proteins and mechanisms have fundamentally changed our perception of lipolysis and its impact on cellular metabolism. New findings that lipolytic products and intermediates participate in cellular signaling processes and that "lipolytic signaling" is particularly important in many nonadipose tissues unveil a previously underappreciated aspect of lipolysis, which may be relevant for human disease.
authors.affiliation: Institute of Molecular Biosciences, University of Graz, Austria. rudolf.zechner@uni-graz.at
authors.forename: Rudolf
authors.initials: R
authors.lastname: Zechner
authors.forename: Robert
authors.initials: R
authors.lastname: Zimmermann
authors.forename: Thomas O
authors.initials: TO
authors.lastname: Eichmann
authors.forename: Sepp D
authors.initials: SD
authors.lastname: Kohlwein
authors.forename: Guenter
authors.initials: G
authors.lastname: Haemmerle
authors.forename: Achim
authors.initials: A
authors.lastname: Lass
authors.forename: Frank
authors.initials: F
authors.lastname: Madeo
mesh_terms: D000818:Animals; D006801:Humans; D008049:Lipase / Q000235:genetics / Q000378:metabolism*; D050356:Lipid Metabolism / Q000235:genetics / Q000502:physiology*; D008066:Lipolysis / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology
chemical_list: D008049:Lipase