title: Evidence for oxygen use in preterm infants.
abstract: OBJECTIVE
  To review the evidence for optimal oxygen use in preterm infants.
  
  
  RESULTS
  Clinicians have embraced lower saturation targets to minimize retinopathy of prematurity (ROP). Large randomized trials now have shown that while such targets reduce ROP, neonatal mortality is increased significantly.
  
  
  CONCLUSIONS
  Preterm infants should be resuscitated with blended oxygen (30-90%) targeted to avoid hyperoxia. Later, saturation management remains uncertain. Until ongoing trials and follow-up are complete, it is prudent to avoid saturation of 85-89%.
authors.affiliation: Division of Neonatology, Rainbow Babies & Childrens Hospital, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH 44106, USA.
authors.forename: Monuj Triven
authors.initials: MT
authors.lastname: Bashambu
authors.forename: Monika
authors.initials: M
authors.lastname: Bhola
authors.forename: Michele
authors.initials: M
authors.lastname: Walsh
mesh_terms: D006801:Humans; D018496:Hyperoxia / Q000139:chemically induced* / Q000517:prevention & control; D007226:Infant Mortality / Q000639:trends; D007230:Infant, Low Birth Weight / Q000097:blood; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood*; D010100:Oxygen / Q000008:administration & dosage / Q000009:adverse effects / Q000097:blood*; D010102:Oxygen Inhalation Therapy / Q000009:adverse effects / Q000592:standards; D012151:Resuscitation / Q000009:adverse effects / Q000379:methods; D012178:Retinopathy of Prematurity / Q000517:prevention & control*
chemical_list: D010100:Oxygen