title: Sensitization to cereals and peanut evidenced by skin prick test and specific IgE in food-tolerant, grass pollen allergic patients.
abstract: BACKGROUND
  The botanical relation between grass and cereal grains may be relevant when diagnosing food allergy to cereals. The aim was to investigate the diagnostic specificity of skin prick test (SPT) and specific immunoglobulin E (sIgE) tests to cereals and peanut in grass pollen allergic subjects without history of, and clinically reactions to foods botanically related to grass.
  
  
  METHODS
  70 subjects (41 females; mean age 32 years) and 20 healthy controls (13 females; mean age 24 years) were tested by open food challenge (OFC) with cereals and peanut. SPT and sIgE both with Immulite® (Siemens) and ImmunoCAP® (Phadia) to grass and birch pollen, cereals, peanut and bromelain were performed.
  
  
  RESULTS
  Of the 65 OFC-negative subjects 29-46% (SPT, depending on cut-off), 20% (Immulite) and 38% (ImmunoCAP) had positive results to one or more of the foods tested. Controls were negative in all tests. Cross-reactive carbohydrate determinants (CCD) as evidenced by reaction to bromelain could explain only a minority of the measured IgE-sensitizations.
  
  
  CONCLUSIONS
  Grass pollen allergic patients with documented food tolerance to cereals and peanut may express significant sensitization. False-positive cereal or peanut allergy diagnoses may be a quantitatively important problem both in routine clinical work and epidemiological studies.
authors.affiliation: Allergy Clinic, Copenhagen University Hospital, Gentofte, Denmark. lkpallgy@mail.dk.
authors.forename: Maria
authors.initials: M
authors.lastname: Martens
authors.forename: Heidi J
authors.initials: HJ
authors.lastname: Schnoor
authors.forename: Hans-Jørgen
authors.initials: HJ
authors.lastname: Malling
authors.forename: Lars K
authors.initials: LK
authors.lastname: Poulsen