title: A sterol and spiroditerpenoids from a Penicillium sp. isolated from a deep sea sediment sample.
abstract: A new polyoxygenated sterol, sterolic acid (1), three new breviane spiroditerpenoids, breviones I-K (2-4), and the known breviones (5-8), were isolated from the crude extract of a Penicillium sp. obtained from a deep sea sediment sample that was collected at a depth of 5115 m. The structures of 1-4 were elucidated primarily by NMR experiments, and 1 was further confirmed by X-ray crystallography. The absolute configurations of 2 and 3 were deduced by comparison of their CD spectra with those of the model compounds. Compounds 2 and 5 showed significant cytotoxicity against MCF-7 cells, which is comparable to the positive control cisplatin.
authors.affiliation: Beijing Institute of Pharmacology & Toxicology, Beijing 100850, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.affiliation: Key Laboratory of Marine Biogenetic Resources, The Third Institute of Oceanography, The State Oceanic Administration, Xiamen 361005, China.
authors.forename: Dezan
authors.initials: D
authors.lastname: Ye
authors.affiliation: Key Laboratory of Marine Biogenetic Resources, The Third Institute of Oceanography, The State Oceanic Administration, Xiamen 361005, China.
authors.forename: Zongze
authors.initials: Z
authors.lastname: Shao
authors.affiliation: Beijing Institute of Pharmacology & Toxicology, Beijing 100850, China.
authors.forename: Chengbin
authors.initials: C
authors.lastname: Cui
authors.affiliation: Beijing Institute of Pharmacology & Toxicology, Beijing 100850, China.
authors.forename: Yongsheng
authors.initials: Y
authors.lastname: Che
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D059001:Aquatic Organisms / Q000302:isolation & purification / Q000378:metabolism*; D001943:Breast Neoplasms / Q000188:drug therapy; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D055808:Drug Discovery; D005260:Female; D005285:Fermentation; D019015:Geologic Sediments / Q000382:microbiology; D006801:Humans; D020128:Inhibitory Concentration 50; D008175:Lung Neoplasms / Q000188:drug therapy; D008297:Male; D015394:Molecular Structure; D010140:Pacific Ocean; D010407:Penicillium / Q000302:isolation & purification / Q000378:metabolism*; D013237:Stereoisomerism; D013261:Sterols / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D000903:Antibiotics, Antineoplastic; D004224:Diterpenes; D013261:Sterols; C573586:sterolic acid