title: Recent developments in enediyne chemistry.
abstract: The enediynes are known for highly potent anticancer, antimicrobial, as well as cytotoxic activities. The discovery of enediynes from natural sources was achieved in late 1980s. They are presently of high interest, because they exert their biological action due to their ability to form a diradical, which abstracts H-atoms from the DNA backbone, thus causing cell death. Nowadays, the major works are dedicated to the syntheses of enediynes. This review covers recent developments in enediyne chemistry of the last few decades. It is subdivided in six chapters dealing with the discussion of the chemistry and biological significances of enediynes, and the factors responsible for a better activation of enediynes and potent biological evaluations.
authors.affiliation: Department of Chemistry, University of Delhi, Delhi-110007, India. mukeshjoshi21@gmail.com
authors.forename: Mukesh C
authors.initials: MC
authors.lastname: Joshi
authors.forename: Diwan S
authors.initials: DS
authors.lastname: Rawat
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D001688:Biological Products / Q000737:chemistry; D004249:DNA Damage / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D053281:Enediynes / Q000138:chemical synthesis / Q000737:chemistry*; D006801:Humans; D047028:Macrocyclic Compounds / Q000737:chemistry; D008670:Metals / Q000737:chemistry; D009369:Neoplasms / Q000188:drug therapy; D011166:Porphyrins / Q000737:chemistry
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D001688:Biological Products; D053281:Enediynes; D047028:Macrocyclic Compounds; D008670:Metals; D011166:Porphyrins