title: Multilevel, hybrid regularization method for reconstruction of fluorescent molecular tomography.
abstract: In this paper, a multilevel, hybrid regularization method is presented for fluorescent molecular tomography (FMT) based on the hp-finite element method (hp-FEM) with a continuous wave. The hybrid regularization method combines sparsity regularization and Landweber iterative regularization to improve the stability of the solution of the ill-posed inverse problem. In the first coarse mesh level, considering the fact that the fluorescent probes are sparsely distributed in the entire reconstruction region in most FMT applications, the sparse regularization method is employed to take full advantage of this sparsity. In the subsequent refined mesh levels, since the reconstruction region is reduced and the initial value of the unknown parameters is provided from the previous mesh, these mesh levels seem to be different from the first level. As a result, the Landweber iterative regularization method is applied for reconstruction. Simulation experiments on a 3D digital mouse atlas and physical experiments on a phantom are conducted to evaluate the performance of our method. The reconstructed results show the potential and feasibility of the proposed approach.
authors.affiliation: Life Sciences Research Center, School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi 710071, China.
authors.forename: Huangjian
authors.initials: H
authors.lastname: Yi
authors.forename: Duofang
authors.initials: D
authors.lastname: Chen
authors.forename: Xiaochao
authors.initials: X
authors.lastname: Qu
authors.forename: Kuan
authors.initials: K
authors.lastname: Peng
authors.forename: Xueli
authors.initials: X
authors.lastname: Chen
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Zhou
authors.forename: Jie
authors.initials: J
authors.lastname: Tian
authors.forename: Jimin
authors.initials: J
authors.lastname: Liang
mesh_terms: D000465:Algorithms; D000818:Animals; D003198:Computer Simulation; D020342:Finite Element Analysis; D005453:Fluorescence; D007091:Image Processing, Computer-Assisted / Q000379:methods; D051379:Mice; D019047:Phantoms, Imaging; D014057:Tomography, X-Ray Computed / Q000295:instrumentation / Q000379:methods*