title: Protein- and peptide-based electrospun nanofibers in medical biomaterials.
abstract: Electrospun fibers are being studied and developed because they hold considerable promise for realizing some advantages of nanostructured materials. The fibers can be made of biocompatible and biodegradable polymers. Electrospinning has therefore attracted interest in biotechnology and medicine, and there has been rapid growth in this area in recent years. This review presents an introduction to polymer nanofiber electrospinning, focusing on the use of natural proteins and synthetic peptides. We summarize key physical properties of protein-based and peptide-based nanofiber mats, survey biomedical applications of these materials, identify key challenges, and outline future prospects for development of the technology for tissue engineering, drug delivery, wound healing, and biosensors.
  
  
  BACKGROUND
  This review focuses on polymer nanofiber electrospinning using natural proteins and synthetic peptides. The authors describe key properties and applications of these materials, and outline future prospects for tissue engineering, drug delivery, wound healing, and biosensors based on these nanomats and nanofibers.
authors.affiliation: Nanomedicine and Nanobiotechnology Laboratory, Department of Physics, University of South Florida, Tampa, Florida 33620, USA.
authors.forename: Dhan B
authors.initials: DB
authors.lastname: Khadka
authors.forename: Donald T
authors.initials: DT
authors.lastname: Haynie
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry; D015374:Biosensing Techniques; D016503:Drug Delivery Systems; D006801:Humans; D057139:Nanofibers / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D011506:Proteins / Q000737:chemistry*; D023822:Tissue Engineering; D014945:Wound Healing
chemical_list: D001672:Biocompatible Materials; D010455:Peptides; D011108:Polymers; D011506:Proteins