title: Lumped parameter model for heart failure with novel regulating mechanisms of peripheral resistance and vascular compliance.
abstract: To research the change in the physiological mechanism between the heart failure (HF) patient and healthy persons, the physiology parameters, which include the myocardial contractility, systemic vascular resistance (SVR), and vascular compliance, were studied. Through clinical data of HF patients, the computing method of the myocardial contractility was proposed; SVR as a function with respect to mean arterial pressure (MAP) was represented; and the vascular compliance was defined as a function with respect to MAP and cardiac output. Based on these parameters, a lumped parameter model of the cardiovascular system was established to reproduce the hemodynamic status of HF patients and verify the validity of the physiological mechanism. The simulation results demonstrate that the proportional error of mean flow, arterial pressure, and systolic blood pressure is 11.9%, 2.3%, and 4.7% compared with the clinical data, respectively. The proportional error of end-diastolic volume, end-systolic volume , and ejection fraction is 13.4%, 3%, and 3.9%, respectively.
authors.affiliation: School of Life Science and BioEngineering, Beijing University of Technology, People's Republic of China.
authors.forename: Kaiyun
authors.initials: K
authors.lastname: Gu
authors.forename: Yu
authors.initials: Y
authors.lastname: Chang
authors.forename: Bin
authors.initials: B
authors.lastname: Gao
authors.forename: Youjun
authors.initials: Y
authors.lastname: Liu
authors.forename: Zhe
authors.initials: Z
authors.lastname: Zhang
authors.forename: Feng
authors.initials: F
authors.lastname: Wan
mesh_terms: D000368:Aged; D001794:Blood Pressure; D001808:Blood Vessels / Q000503:physiopathology*; D003187:Compliance; D005260:Female; D006333:Heart Failure / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D014655:Vascular Resistance