title: Prognosis of cerebral vein thrombosis presenting as isolated headache: early vs. late diagnosis.
abstract: OBJECTIVE
  To analyse the outcome of cerebral venous thrombosis (CVT) patients presenting with isolated headache, specifically to compare isolated headache patients with early vs. late CVT diagnosis.
  
  
  METHODS
  In the International Study on Cerebral Vein and Dural Sinus Thrombosis (ISCVT) database we compared the outcome of patients with isolated headache and a CVT diagnosed early (≤7 days from onset) vs. late (>7 days). We retrieved 100 patients with isolated headache, 52 patients with early CVT diagnosis (early isolated headache) and 48 with late CVT diagnosis (late isolated headache).
  
  
  RESULTS
  Neurological worsening was more frequent within early isolated headache patients (23% vs. 8%) (p = 0.045). At the last follow-up (median 411 days), 93% patients had a complete recovery, and 4% were dead or dependent, with no significant difference between early isolated headache and late isolated headache.
  
  
  CONCLUSIONS
  The outcome of CVT patients with isolated headache diagnosed early or late was similarly favourable, but there was a higher proportion of neurological worsening in the acute phase among early isolated headache patients, who need close neurological monitoring.
authors.affiliation: University of Lisbon, Lisbon, Portugal.
authors.forename: Joana
authors.initials: J
authors.lastname: Gameiro
authors.forename: José M
authors.initials: JM
authors.lastname: Ferro
authors.forename: Patricia
authors.initials: P
authors.lastname: Canhão
authors.forename: Jan
authors.initials: J
authors.lastname: Stam
authors.forename: Fernando
authors.initials: F
authors.lastname: Barinagarrementeria
authors.forename: Arne
authors.initials: A
authors.lastname: Lindgren
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D015897:Comorbidity; D057210:Delayed Diagnosis / Q000706:statistics & numerical data; D042241:Early Diagnosis; D005260:Female; D006261:Headache / Q000175:diagnosis* / Q000453:epidemiology*; D006801:Humans; D038622:Internationality; D020767:Intracranial Thrombosis / Q000175:diagnosis* / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D018570:Risk Assessment; D012307:Risk Factors; D017678:Sex Distribution; D020246:Venous Thrombosis / Q000175:diagnosis* / Q000453:epidemiology*; D055815:Young Adult