title: Portal vein thrombosis in inflammatory bowel diseases: a single-center case series.
abstract: METHODS
  Portal vein thrombosis (PVT) has been reported as a complication of IBD in some case reports. We describe the presentation, diagnostic approaches, underlying risks factors and clinical outcome of 8 IBD patients with PVT. CASE-SERIES: The patients presented with partial PVT (4 patients) or portal cavernoma. Five patients had undergone surgery. In 2 patients portal biliopathy was diagnosed after detection of PVT. In 4 patients, the diagnosis of PVT was made while IBD was in remission. Five patients showed at least one risk factor for hypercoagulability: lupus anti-coagulant (one patient), increased von Willebrand factor (2 patients) or homocysteine levels (4 patients). Four patients received anticoagulant therapy for 6 months. None experienced other thrombotic events during a median of 5 years (range 2-8 years).
  
  
  CONCLUSIONS
  PVT is a potential complication of IBD, usually associated with acquired or inherited risks factors for hypercoagulability and with a benign outcome.
authors.affiliation: Gastrointestinal Unit, Department of Clinical Sciences, L.Sacco University Hospital, Milan, Italy. giovanni.maconi@unimi.it
authors.forename: Giovanni
authors.initials: G
authors.lastname: Maconi
authors.forename: Elena
authors.initials: E
authors.lastname: Bolzacchini
authors.forename: Alessandra
authors.initials: A
authors.lastname: Dell'Era
authors.forename: Umberto
authors.initials: U
authors.lastname: Russo
authors.forename: Sandro
authors.initials: S
authors.lastname: Ardizzone
authors.forename: Roberto
authors.initials: R
authors.lastname: de Franchis
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D003093:Colitis, Ulcerative / Q000150:complications*; D003424:Crohn Disease / Q000150:complications*; D005260:Female; D006710:Homocysteine / Q000097:blood; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000097:blood; D008297:Male; D008875:Middle Aged; D011169:Portal Vein; D012189:Retrospective Studies; D012307:Risk Factors; D019851:Thrombophilia / Q000097:blood / Q000150:complications / Q000235:genetics; D020246:Venous Thrombosis / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D014841:von Willebrand Factor / Q000378:metabolism
chemical_list: D000925:Anticoagulants; D016682:Lupus Coagulation Inhibitor; D014841:von Willebrand Factor; D006710:Homocysteine