title: Differential impairment of source memory in progressive versus non-progressive behavioral variant frontotemporal dementia.
abstract: Episodic memory has recently been shown to be impaired in the behavioral variant of frontotemporal dementia (bvFTD) when so-called non-progressive cases are excluded. Such non-progressive cases present with the behavioral features of bvFTD, but show no evidence of cognitive decline over time. To date, evidence regarding episodic memory performance in bvFTD subgroups on more stringent tasks is lacking. We investigated temporal and spatial source memory in progressive (n = 7) versus non-progressive (n = 12) bvFTD. BvFTD cases were retrospectively classified based on general cognitive decline on the Addenbrooke's Cognitive Examination Revised, and the presence of atrophy on structural neuroimaging, over 3 years following diagnosis. Progressors showed impaired temporal and spatial source retrieval. Non-progressors displayed temporal source deficits only. These differential source memory profiles point to the variability of episodic memory performance in bvFTD, and underscore the importance of differential diagnosis of bvFTD subgroups using longitudinal and neuroimaging data.
authors.affiliation: Neuroscience Research Australia, Sydney, Australia. m.irish@neura.edu.au
authors.forename: Muireann
authors.initials: M
authors.lastname: Irish
authors.forename: Andrew
authors.initials: A
authors.lastname: Graham
authors.forename: Kim S
authors.initials: KS
authors.lastname: Graham
authors.forename: John R
authors.initials: JR
authors.lastname: Hodges
authors.forename: Michael
authors.initials: M
authors.lastname: Hornberger
mesh_terms: D000368:Aged; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology*; D003937:Diagnosis, Differential; D018450:Disease Progression; D005260:Female; D057180:Frontotemporal Dementia / Q000150:complications*; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000145:classification / Q000175:diagnosis* / Q000209:etiology*; D061212:Memory, Episodic; D008609:Mental Status Schedule; D008875:Middle Aged; D009483:Neuropsychological Tests; D018709:Statistics, Nonparametric