title: Long-term follow-up of the TIPS early detection in psychosis study: effects on 10-year outcome.
abstract: OBJECTIVE
  Early detection in first-episode psychosis confers advantages for negative, cognitive, and depressive symptoms after 1, 2, and 5 years, but longitudinal effects are unknown. The authors investigated the differences in symptoms and recovery after 10 years between regional health care sectors with and without a comprehensive program for the early detection of psychosis.
  
  
  METHODS
  The authors evaluated 281 patients (early detection, N=141) 18 to 65 years old with a first episode of nonaffective psychosis between 1997 and 2001. Of these, 101 patients in the early-detection area and 73 patients in the usual-detection area were followed up at 10 years, and the authors compared their symptoms and recovery.
  
  
  RESULTS
  A significantly higher percentage of early-detection patients had recovered at the 10-year follow-up relative to usual-detection patients. This held true despite more severely ill patients dropping out of the study in the usual-detection area. Except for higher levels of excitative symptoms in the early-detection area, there were no symptom differences between the groups. Early-detection recovery rates were higher largely because of higher employment rates for patients in this group.
  
  
  CONCLUSIONS
  Early detection of first-episode psychosis appears to increase the chances of milder deficits and superior functioning. The mechanisms by which this strategy improves the long-term prognosis of psychosis remain speculative. Nevertheless, our findings over 10 years may indicate that a prognostic link exists between the timing of intervention and outcome that deserves additional study.
authors.affiliation: Division of Psychiatry, Stavanger University Hospital, Regional Center for Clinical Research in Psychosis, Health West, Norway. wenchetenvelden@me.com
authors.forename: Wenche Ten Velden
authors.initials: WT
authors.lastname: Hegelstad
authors.forename: Tor K
authors.initials: TK
authors.lastname: Larsen
authors.forename: Bjørn
authors.initials: B
authors.lastname: Auestad
authors.forename: Julie
authors.initials: J
authors.lastname: Evensen
authors.forename: Ulrik
authors.initials: U
authors.lastname: Haahr
authors.forename: Inge
authors.initials: I
authors.lastname: Joa
authors.forename: Jan O
authors.initials: JO
authors.lastname: Johannesen
authors.forename: Johannes
authors.initials: J
authors.lastname: Langeveld
authors.forename: Ingrid
authors.initials: I
authors.lastname: Melle
authors.forename: Stein
authors.initials: S
authors.lastname: Opjordsmoen
authors.forename: Jan Ivar
authors.initials: JI
authors.lastname: Rossberg
authors.forename: Bjørn Rishovd
authors.initials: BR
authors.lastname: Rund
authors.forename: Erik
authors.initials: E
authors.lastname: Simonsen
authors.forename: Kjetil
authors.initials: K
authors.lastname: Sundet
authors.forename: Per
authors.initials: P
authors.lastname: Vaglum
authors.forename: Svein
authors.initials: S
authors.lastname: Friis
authors.forename: Thomas
authors.initials: T
authors.lastname: McGlashan
mesh_terms: D000328:Adult; D003718:Denmark; D042241:Early Diagnosis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009664:Norway; D010043:Outcome and Process Assessment, Health Care / Q000706:statistics & numerical data*; D011379:Prognosis; D011618:Psychotic Disorders / Q000175:diagnosis*