title: A patient with tyrosine kinase 2 deficiency without hyper-IgE syndrome.
abstract: We describe a Turkish patient with tyrosine kinase 2 deficiency who suffered from disseminated Bacille Calmette-Guerin infection, neurobrucellosis, and cutaneous herpes zoster infection. Tyrosine kinase 2 deficiency should be considered in patients susceptible to herpes viruses and intramacrophage pathogens even in the absence of atopy, high serum IgE, and staphylococcal disease.
authors.affiliation: Department of Pediatrics, Uludag University School of Medicine, Bursa, Turkey. sebnemkl@uludag.edu.tr
authors.forename: Sara S
authors.initials: SS
authors.lastname: Kilic
authors.forename: Mustafa
authors.initials: M
authors.lastname: Hacimustafaoglu
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Boisson-Dupuis
authors.forename: Alexandra Y
authors.initials: AY
authors.lastname: Kreins
authors.forename: Audrey V
authors.initials: AV
authors.lastname: Grant
authors.forename: Laurent
authors.initials: L
authors.lastname: Abel
authors.forename: Jean-Laurent
authors.initials: JL
authors.lastname: Casanova
mesh_terms: D002648:Child; D003937:Diagnosis, Differential; D005500:Follow-Up Studies; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000175:diagnosis / Q000201:enzymology*; D007589:Job Syndrome / Q000175:diagnosis; D008279:Magnetic Resonance Imaging; D008297:Male; D053634:TYK2 Kinase / Q000097:blood / Q000172:deficiency*
chemical_list: D053634:TYK2 Kinase