title: [Multidrug-resistant Pseudomonas aeruginosa T].
abstract: The emergence of Pseudomonas aeruginosa strains resistant to carbapenems, fluoroquinolones and amikacin, which were defined as multidrug-resistant (MDR) strains, is a serious problem in Japan. Nosocomial outbreaks of MDR P. aeruginosa infection have become problematic in hospitals. The percentage of MDR isolates at medical facilities was about 2.5% of P. aeruginosa isolates. Furthermore, clonal expansion of P. aeruginosa strains highly resistant to these antibiotics with MICs of more than 64 microg/mL occurred in community hospitals. Most of these multidrug highly resistant strains produced metallo-beta-lactamase IMP-1 and aminoglycoside 6'-N-acetyltransferase AAC(6')-Iae. An immunochromatographic assay was developed for the rapid detection of these enzymes producing strains. The developed assay is an easy-to-use and reliable detection method for the multidrug highly resistant P. aeruginosa.
authors.affiliation: Department of Infectious Diseases, Research Institute, National Center for Global Health and Medicine.
authors.forename: Teruo
authors.initials: T
authors.lastname: Kirikae
mesh_terms: D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D011552:Pseudomonas Infections / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification