title: A chromo- and fluorogenic sensor for probing the cancer biomarker lysophosphatidic acid.
abstract: A novel chromo- and fluorogenic sensor, 4-(4-dimethylaminostyryl)-1-hexadecylpyridinium (DSHP) for lysophosphatidic acid (LPA) was successfully developed by incorporating a long alkyl chain into the cyanine molecule. DSHP shows excellent selectivity and high sensitivity towards LPA with a detection limit of about 7.09 × 10(-7) M based on electrostatic and hydrophobic interactions between the sensor and LPA. Upon addition of LPA ranging from 0 to 7.5 × 10(-4) M, DSHP displays an 'on-off-on' fluorescence response and obvious colour change. Good linear relationships between the fluorescence intensity and LPA concentrations were achieved in the fluorescence quenching ranges of 0-28 μM and 34-52 μM, which could be attributed to the combined effects of the photoinduced electron transfer and LPA-induced aggregation of the sensor molecules.
authors.affiliation: Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
authors.forename: Wenwen
authors.initials: W
authors.lastname: Zhao
authors.forename: Weimin
authors.initials: W
authors.lastname: Liu
authors.forename: Wenjun
authors.initials: W
authors.lastname: Zhang
authors.forename: Lintao
authors.initials: L
authors.lastname: Zeng
authors.forename: Zhiyuan
authors.initials: Z
authors.lastname: Fan
authors.forename: Jiasheng
authors.initials: J
authors.lastname: Wu
authors.forename: Pengfei
authors.initials: P
authors.lastname: Wang
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry*; D014408:Biomarkers, Tumor / Q000378:metabolism*; D015374:Biosensing Techniques; D005456:Fluorescent Dyes / Q000378:metabolism*; D008246:Lysophospholipids / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D011726:Pyridinium Compounds / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D055672:Static Electricity
chemical_list: C573333:4-(4-dimethylaminostyryl)-1-hexadecylpyridinium; D000814:Aniline Compounds; D014408:Biomarkers, Tumor; D005456:Fluorescent Dyes; D008246:Lysophospholipids; D011726:Pyridinium Compounds