title: Changes in response bias with different study-test delays: evidence from young adults, older adults, and patients with Alzheimer's disease.
abstract: OBJECTIVE
  Along with impaired discrimination, patients with Alzheimer's disease (AD) often show an abnormally liberal response bias (greater tendency to respond "old"). Previously we matched discrimination by varying study-test list length and found that participants' usual bias is maintained, such that patients with AD were more liberal than healthy controls. However, this pattern could be a result of the way in which discrimination was matched. In this experiment, we examined whether matching discrimination with the use of a delay would lead to a liberal response bias in healthy younger and older adults as it might lead to the use of more similar memorial processing to the patients with AD.
  
  
  METHODS
  Younger adults, older adults, and patients with AD were run in 2 study-test sessions, with study and recognition test separated by either a 1-min or 1-day delay.
  
  
  RESULTS
  With the 1-min delay, both younger adults and healthy older adults showed a conservative response bias, while patients with AD showed a liberal response bias. When discrimination was matched between patients with AD and controls by the use of a delay, response bias was also matched, with all participants showing a more liberal response bias.
  
  
  CONCLUSIONS
  The current study suggests that how discrimination is matched between patients with AD and controls matters greatly. Potentially, this liberal bias is a result of healthy younger and older adults relying primarily on familiarity at the longer delay, thus using more similar memorial processes to patients with AD who are dependent on familiarity at any delay.
authors.affiliation: Center for Translational Cognitive Neuroscience, VA Boston Healthcare System, 150 S. Huntington Ave, Boston, MA 02130, USA. rdeason@bu.edu
authors.forename: Rebecca G
authors.initials: RG
authors.lastname: Deason
authors.forename: Erin P
authors.initials: EP
authors.lastname: Hussey
authors.forename: Brandon A
authors.initials: BA
authors.lastname: Ally
authors.forename: Andrew E
authors.initials: AE
authors.lastname: Budson
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000503:physiopathology*; D016022:Case-Control Studies; D004192:Discrimination, Psychological; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D021641:Recognition, Psychology; D013997:Time Factors