title: [Research progress on MKP-1 in tumor drug resistance].
abstract: The main obstacle for chemotherapy is tumor drug resistance. Studying the mechanisms of drug resistance and reversing drug resistance is the key to improve the effectiveness of chemotherapy. It has been reported that MKP-1 plays an important role in tumor drug resistance. MKP-1, as a negative regulator of MAPKs, is involved in the MAPKs mediated drug resistance and is regulated by ERK and p38 signaling pathways.However, the relationship between MKP-1 and other drug resistance-related signaling pathways is not clear and requires further investigation.
authors.affiliation: Department of Biochemistry and Genetics, Zhejiang University School of Medicine, Hangzhou 310058 China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Hai
authors.forename: Xiu-wen
authors.initials: XW
authors.lastname: Tang
mesh_terms: D019008:Drug Resistance, Neoplasm / Q000502:physiology*; D054638:Dual Specificity Phosphatase 1 / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D015398:Signal Transduction
chemical_list: D054638:Dual Specificity Phosphatase 1