title: Follicle stimulating hormone receptor G-29A, 919A>G, 2039A>G polymorphism and the risk of male infertility: a meta-analysis.
abstract: Studies of the relationship between male infertility and polymorphisms in the regions of FSHR G-29A (rs1394205), 919A>G (Thr(307)Ala, rs6165) and 2039A>G (Asn(680)Ser, rs6166) have reported inconsistent results. To assess the association between them, a meta-analysis was conducted. PubMed and CBMdisc literature search were conducted to identify all eligible studies investigating such a relationship. The pooled ORs were performed for co-dominant model, dominant model and recessive model in FSHR G-29A, Thr(307)Ala and Asn(680)Ser respectively to assess the strength of association. A total of 1644 male infertility cases and 1748 controls were collected from seven case-control studies. In the overall analysis, no significant association between the three polymorphisms and risk of male infertility was observed. Stratified analysis showed that there were no significantly increased risks of azoospermia and oligoasthenoteratozoospermia (OAT) in any of the genetic models. This meta-analysis supports that FSHR G-29A, Thr(307)Ala and Asn(680)Ser polymorphisms may not be capable of causing male infertility susceptibility.
authors.affiliation: State Key Laboratory of Reproductive Medicine, Institute of Toxicology, Nanjing Medical University, Nanjing 210029, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Wu
authors.forename: Hongquan
authors.initials: H
authors.lastname: Cai
authors.forename: Hong
authors.initials: H
authors.lastname: Sun
authors.forename: Jing
authors.initials: J
authors.lastname: Lu
authors.forename: Dan
authors.initials: D
authors.lastname: Zhao
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Qin
authors.forename: Xiumei
authors.initials: X
authors.lastname: Han
authors.forename: Xiaobing
authors.initials: X
authors.lastname: Niu
authors.forename: Chuncheng
authors.initials: C
authors.lastname: Lu
authors.forename: Yankai
authors.initials: Y
authors.lastname: Xia
authors.forename: Shoulin
authors.initials: S
authors.lastname: Wang
authors.forename: Bart
authors.initials: B
authors.lastname: De Moor
authors.forename: Kathleen
authors.initials: K
authors.lastname: Marchal
authors.forename: Xinru
authors.initials: X
authors.lastname: Wang
mesh_terms: D020022:Genetic Predisposition to Disease; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011962:Receptors, FSH / Q000235:genetics*; D012306:Risk
chemical_list: D011962:Receptors, FSH