title: [A case of resected rectal cancer with hepatic node and multiple liver metastases effectively treated by preoperative modified FOLFOX6 and sLV5FU2 chemotherapy].
abstract: A 55-year-old male had complained of melena.Colonoscopy revealed a type 2 tumor at the rectum.CT demonstrated hepatic lymph nodes and multiple liver metastases(stage IV).Low anterior resection was performed(tub2, RsRa, circ, type 2, pSS, pN1, sH3, cHN1, sP0, cM0: fstage IV).The patient was treated with mFOLFOX6 and sLV5FU2 after operation.CT revealed a partial response after 14 courses of systemic chemotherapy.sLV5 FU2 therapy was converted to capecitabine because he experienced bone marrow suppression.CT showed that the liver metastases had enlarged but the hepatic lymph nodes disappeared.Right portal vein embolization was performed.After 4 weeks, right hepatectomy and hepatic lymph node dissection were performed.Preoperative chemotherapy with mFOLFOX6 seems beneficial as a neoadjuvant chemotherapy for hepatic lymph node-positive advanced colorectal cancer.
authors.affiliation: Dept. of Surgery, Tottori Municipal Hospital, Japan.
authors.forename: Ken
authors.initials: K
authors.lastname: Seshimo
authors.forename: Masahiro
authors.initials: M
authors.lastname: Oishi
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Toshima
authors.forename: Hideaki
authors.initials: H
authors.lastname: Ikeda
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kato
authors.forename: Masao
authors.initials: M
authors.lastname: Yamamura
authors.forename: Masahito
authors.initials: M
authors.lastname: Kodera
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Yamashita
authors.forename: Noriaki
authors.initials: N
authors.lastname: Tanaka
authors.forename: Hiraku
authors.initials: H
authors.lastname: Fujita
authors.forename: Koutaro
authors.initials: K
authors.lastname: Shibagaki
authors.forename: Hideaki
authors.initials: H
authors.lastname: Taniguchi
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Matsuki
authors.forename: Keita
authors.initials: K
authors.lastname: Kobayashi
authors.forename: Keiko
authors.initials: K
authors.lastname: Takita
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D005472:Fluorouracil / Q000627:therapeutic use*; D006801:Humans; D002955:Leucovorin / Q000627:therapeutic use*; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009944:Organoplatinum Compounds / Q000627:therapeutic use; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed
chemical_list: D000964:Antimetabolites, Antineoplastic; D009944:Organoplatinum Compounds; D002955:Leucovorin; D005472:Fluorouracil