title: Childhood acute myeloid leukemia with bone marrow eosinophilia caused by t(16;21)(q24;q22).
abstract: Acute myeloid leukemia with abnormal bone marrow eosinophilia (AML-M4Eo) is often reported in core binding factor (CBF) leukemia, with translocations such as inv(16)(p13q22), t(16;16)(p13;q22) or t(8;21)(q22;q22); however, it is rarely reported with t(16;21)(q24;q22), which produces the RUNX1-CBFA2T3 (AML1-MTG16) chimera. The similarity between this chimera and RUNX1-RUNXT1 (AML1-MTG8) by t(8;21)(q22;q22) remains controversial. Adult leukemia with t(16;21)(q24;q22) was primarily therapy related, and shows poor prognosis; however, pediatric AML with this translocation was quite rare and tended to be de novo AML. We present here a 4-year-old boy with de novo AML-M4Eo and t(16;21)(q24;q22). He received chemotherapy and survived for more than 70 months without transplantation. We speculated that pediatric AML with t(16;21)(q24;q22) showed favorable prognosis, as with t(8;21)(q22;q22).
authors.affiliation: Division of Hematology/Oncology, Children's Medical Center, Japanese Red Cross Nagoya First Hospital, 3-35, Michishita-cho, Nakamura-ku, Nagoya, Aichi, 453-8511, Japan. kwnozomu@med.nagoya-u.ac.jp
authors.forename: Nozomu
authors.initials: N
authors.lastname: Kawashima
authors.forename: Akira
authors.initials: A
authors.lastname: Shimada
authors.forename: Takeshi
authors.initials: T
authors.lastname: Taketani
authors.forename: Yasuhide
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Nao
authors.initials: N
authors.lastname: Yoshida
authors.forename: Kimikazu
authors.initials: K
authors.lastname: Matsumoto
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Seiji
authors.initials: S
authors.lastname: Kojima
authors.forename: Koji
authors.initials: K
authors.lastname: Kato
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D001853:Bone Marrow / Q000378:metabolism / Q000473:pathology; D002648:Child; D002885:Chromosomes, Human, Pair 16; D002891:Chromosomes, Human, Pair 21; D050676:Core Binding Factor Alpha 2 Subunit / Q000235:genetics*; D004802:Eosinophilia / Q000150:complications* / Q000235:genetics / Q000473:pathology; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000188:drug therapy / Q000235:genetics / Q000473:pathology; D008297:Male; D012097:Repressor Proteins / Q000235:genetics*; D014178:Translocation, Genetic; D025521:Tumor Suppressor Proteins / Q000235:genetics*
chemical_list: D000970:Antineoplastic Agents; C115744:CBFA2T3 protein, human; D050676:Core Binding Factor Alpha 2 Subunit; D012097:Repressor Proteins; D025521:Tumor Suppressor Proteins