title: Photothermal effects of folate-conjugated Au nanorods on HepG2 cells.
abstract: Photothermal cancer therapy, as a prospective approach for local cancer treatment, is attracting increasing interests. In this paper, gold nanorods were conjugated with folate (folate/AuNRs), and their photothermal effects on hepatocellular carcinoma cell line (HepG2) using MTT assay, flow cytometry, as well as on the cellular morphology, cytoskeleton, cell surface adhesion, and stiffness detected at subcellular level by an atomic force microscope (AFM) were investigated. The results indicated that near-infrared laser-induced hyperthermia of folate/AuNRs could break the cell membrane integrity and homeostasis and then lead to the depolymerization of cytoskeleton and influx of intracellular Ca(2+). Thus, folate/AuNRs can be as effective and promising nanomaterials for photothermal therapy of folate receptor bearing tumor.
authors.affiliation: Department of Chemistry and Institute for Nano-chemistry, Jinan University, Guangzhou, China. 136435501@qq.com
authors.forename: Hua
authors.initials: H
authors.lastname: Jin
authors.forename: Peihui
authors.initials: P
authors.lastname: Yang
authors.forename: Jiye
authors.initials: J
authors.lastname: Cai
authors.forename: Jinhui
authors.initials: J
authors.lastname: Wang
authors.forename: Mei
authors.initials: M
authors.lastname: Liu
mesh_terms: D002470:Cell Survival / Q000528:radiation effects; D005434:Flow Cytometry; D005492:Folic Acid / Q000378:metabolism*; D006046:Gold / Q000378:metabolism*; D056945:Hep G2 Cells; D022781:Hepatocytes / Q000502:physiology* / Q000528:radiation effects*; D006358:Hot Temperature; D006801:Humans; D008027:Light; D018625:Microscopy, Atomic Force; D043942:Nanotubes; D010789:Phototherapy / Q000379:methods; D013194:Staining and Labeling / Q000379:methods; D013778:Tetrazolium Salts / Q000378:metabolism; D013844:Thiazoles / Q000378:metabolism
chemical_list: D013778:Tetrazolium Salts; D013844:Thiazoles; D006046:Gold; D005492:Folic Acid; C022616:thiazolyl blue