title: Toxic effects of deltamethrin and λ-cyhalothrin on Xenopus laevis tadpoles.
abstract: This study evaluates the toxic effects of deltamethrin and λ-cyhalothrin on Xenopus laevis tadpoles after 168 h of exposure. The LC(50) of deltamethrin and λ-cyhalothrin at 168 h was calculated as the μg of active ingredient per liter (μg AI/L). According to these values, the LC(50) was 6.26 and 3.94 μg AI/L for deltamethrin and λ-cyhalothrin, respectively. Several enzymes were studied for early signs of intoxication following exposure to the pesticides for 24 h. Glutathione-S-transferase,carboxylesterase, and lactate dehydrogenase were inhibited by λ-cyhalothrin, and both pesticides inhibited acid phosphatase and aspartate aminotransferase. In contrast, acetylcholinesterase was activated by deltamethrin. The results suggest that X. laevis is sensitive to the pyrethroids that were tested, and the enzyme responses suggest that they are potential biomarkers for evaluating the toxic effect of pyrethroids on amphibians in environmental conditions.
authors.affiliation: Faculty of Medicine, Ankara University, Ankara, Turkey.
authors.forename: Handan
authors.initials: H
authors.lastname: Aydin-Sinan
authors.forename: Abbas
authors.initials: A
authors.lastname: Güngördü
authors.forename: Murat
authors.initials: M
authors.lastname: Ozmen
mesh_terms: D000818:Animals; D004781:Environmental Exposure; D004784:Environmental Monitoring; D007814:Larva / Q000187:drug effects* / Q000254:growth & development; D009570:Nitriles / Q000633:toxicity*; D011722:Pyrethrins / Q000633:toxicity*; D014982:Xenopus laevis / Q000254:growth & development*
chemical_list: D009570:Nitriles; D011722:Pyrethrins; C017180:decamethrin; C037304:cyhalothrin