title: Upward gaze and head deviation with frontal eye field stimulation.
abstract: Using electrical stimulation to the deep, most caudal part of the right frontal eye field (FEF), we demonstrate a novel pattern of vertical (upward) eye movement that was previously only thought possible by stimulating both frontal eye fields simultaneously. If stimulation was started when the subject looked laterally, the initial eye movement was back to the midline, followed by upward deviation. Our finding challenges current view of topological organisation in the human FEF and may have general implications for concepts of topological organisation of the motor cortex, since sustained stimulation also induced upward head movements as a component of the vertical gaze shift. [Published with video sequences].
authors.affiliation: Epilepsy Center, Department of Neurology, University Hospitals Case Medical Center. Kitti.Kaiboriboon@UHhospitals.org
authors.forename: Kitti
authors.initials: K
authors.lastname: Kaiboriboon
authors.forename: Hans O
authors.initials: HO
authors.lastname: Lüders
authors.forename: Jonathan P
authors.initials: JP
authors.lastname: Miller
authors.forename: R John
authors.initials: RJ
authors.lastname: Leigh
mesh_terms: D046690:Deep Brain Stimulation; D004833:Epilepsy, Temporal Lobe / Q000503:physiopathology* / Q000601:surgery; D005133:Eye Movements / Q000502:physiology*; D005625:Frontal Lobe / Q000503:physiopathology* / Q000601:surgery; D019416:Head Movements / Q000502:physiology; D006801:Humans; D008297:Male; D055815:Young Adult