title: Target-size embracing dimension for sensitive detection of viruses with various sizes and influenza virus strains.
abstract: The focused ion beam (FIB) technique was employed to precisely fabricate hexagon-like Au nano-rods (fibAu_h) arrays as a surface enhanced Raman scattering - active substrate. A "ring diameter" (D(R)) was created by the convergence of three fibAu_h with respect to the dimension of the target viruses (D(T)), such as adenovirus (Adeno), encephalomyocarditis virus (EMCV), influenza virus (H1N1) with different sizes. Three influenza A virus strains were also compared. The results indicate that as that with a D(R)/D(T) ratio of around 1, the discrimination ability for detecting the target viruses and SERS mechanism become obvious. The enhanced lightning rod effect surrounding the seized target virus is anticipated if its size and dimension is suitably embraced within three fibAu_h. Hence the as-designed fibAu_h sample with a target-size embracing dimension provides good discrimination ability for distinguishing virus of various sizes or virus strains.
authors.affiliation: Department of Materials Science and Engineering, National Cheng Kung University, 1 University Road, Tainan 70101, Taiwan.
authors.forename: Ying-Yi
authors.initials: YY
authors.lastname: Lin
authors.affiliation: Department of Materials Science and Engineering, National Cheng Kung University, 1 University Road, Tainan 70101, Taiwan; Innovation Center for Advanced Medical Device Technology, National Cheng Kung University, 1 University Road, Tainan 70101, Taiwan. Electronic address: jdliao@mail.ncku.edu.tw.
authors.forename: Jiunn-Der
authors.initials: JD
authors.lastname: Liao
authors.affiliation: Institute of Basic Medical Sciences, National Cheng Kung University, 1 University Road, Tainan 70101, Taiwan.
authors.forename: Mei-Lin
authors.initials: ML
authors.lastname: Yang
authors.affiliation: Institute of Basic Medical Sciences, National Cheng Kung University, 1 University Road, Tainan 70101, Taiwan; Department of Biochemistry and Molecular Biology, National Cheng Kung University, 1 University Road, Tainan 70101, Taiwan.
authors.forename: Chao-Liang
authors.initials: CL
authors.lastname: Wu
mesh_terms: D000256:Adenoviridae / Q000302:isolation & purification / Q000648:ultrastructure; D000818:Animals; D015374:Biosensing Techniques / Q000379:methods* / Q000706:statistics & numerical data; D022081:Cell Surface Extensions; D004686:Encephalomyocarditis virus / Q000302:isolation & purification / Q000648:ultrastructure; D006046:Gold; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype / Q000302:isolation & purification / Q000648:ultrastructure; D009980:Influenza A virus / Q000302:isolation & purification* / Q000648:ultrastructure; D053768:Metal Nanoparticles; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D012680:Sensitivity and Specificity; D013059:Spectrum Analysis, Raman; D014776:Virus Cultivation; D014780:Viruses / Q000302:isolation & purification* / Q000648:ultrastructure
chemical_list: D006046:Gold