title: Functional interactions between B lymphocytes and the innate immune system.
abstract: The immune system is composed of multiple cell types, which together improve the resistance of the organism against infections. The unfolding of a successful host response ensuring effective protection against pathogens requires an appropriate coordination of the different players of the immune system. Innate cells and T cells extensively communicate during immune reactions, providing multiple opportunities for the mutual coordination of these two defense pathways. Little is known about the functional interactions between B and innate cells, and it is generally assumed that they influence each other indirectly through effects on T cells. However, recent studies highlighted important roles for innate cells in initial presentation of antigen to B cells after immunization, and in long-term maintenance of antibody-producing cells in bone marrow after resolution of immune responses. Furthermore, it was found that activated B cells could regulate the activity of innate cells through production of cytokines. Here, we review how direct interactions between innate and B cells can contribute to orchestration of humoral and cellular immunity.
authors.affiliation: Deutsches Rheuma- ForschungsZentrum, Chariteplatz 1, 10117 Berlin, Germany.
authors.forename: Vicky
authors.initials: V
authors.lastname: Lampropoulou
authors.forename: Ping
authors.initials: P
authors.lastname: Shen
authors.forename: Ellen
authors.initials: E
authors.lastname: Hilgenberg
authors.forename: Stefanie
authors.initials: S
authors.lastname: Ries
authors.forename: Christian
authors.initials: C
authors.lastname: Opitz
authors.forename: Simon
authors.initials: S
authors.lastname: Fillatreau
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D001853:Bone Marrow / Q000276:immunology; D002450:Cell Communication / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D056724:Immunity, Humoral; D007113:Immunity, Innate; D008213:Lymphocyte Activation / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D016207:Cytokines