title: Effect of the interleukin-1B gene on serum oxidized low-density lipoprotein levels.
abstract: OBJECTIVE
  To investigate the association of the +3953 IL-1B gene polymorphism in healthy subjects with serum oxidized LDL (oxLDL) levels.
  
  
  METHODS
  We selected 255 subjects who were non-smokers and who had no cardiovascular or other chronic degenerative diseases, and we measured the oxLDL and other glucose levels, lipid biomarkers and biological variables that are related to cardiovascular metabolism. The +3953 IL-1B gene polymorphism was determined using molecular genetics techniques (PCR-RFLP).
  
  
  RESULTS
  A significant association among the +3953 IL-1B genotypes and the oxLDL level was observed. The TT genotype presented lower oxLDL levels than the other genotypes. A multivariate analysis showed that this result was independent of the sex, age, obesity and hypertension status of the subjects.
  
  
  CONCLUSIONS
  Our results suggest that the IL-1B gene polymorphism affects the modulation of serum oxLDL levels.
authors.affiliation: Programa de Pós-Graduação em Bioquímica Toxicológica, Universidade Federal de Santa Maria, Santa Maria, RS, Brazil.
authors.forename: Maria Fernanda
authors.initials: MF
authors.lastname: Manica-Cattani
authors.forename: Marta Maria Medeiros Frescura
authors.initials: MM
authors.lastname: Duarte
authors.forename: Euler Esteves
authors.initials: EE
authors.lastname: Ribeiro
authors.forename: Raul
authors.initials: R
authors.lastname: de Oliveira
authors.forename: Ivana Beatrice
authors.initials: IB
authors.lastname: Mânica da Cruz
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D005260:Female; D006801:Humans; D053583:Interleukin-1beta / Q000097:blood / Q000235:genetics*; D050356:Lipid Metabolism; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D015415:Biomarkers; D001786:Blood Glucose; D053583:Interleukin-1beta; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein