title: [A case of malignant peritoneal mesothelioma successfully treated with systemic chemothrapy].
abstract: A 64-year-old man with a 2-month history of abdominal distension was admitted for transient cerebral ischemic attack. A CT scan revealed massive ascites. Laparoscopy showed multiple whitish nodules on the visceral peritoneum and the omentum. Peritoneal biopsy revealed tumor cells consistent with malignant peritoneal mesothelioma (MPeM). Pemetrexed in combination with cisplatin was administered because it has been reported to be active in patients with MPeM. However his disease progressed. As second-line therapy paclitaxel was tried which yielded a complete response (CR). Eighteen months later he developed abdominal pain of the right upper region where a CT scan showed a mass with surrounding inflammation. As third-line therapy, gemcitabine was administered and again resulted in a CR. He is alive at 3 years from first presenting. Searches for case studies published in medical journals on MPeM were carried out, and 59 cases were analyzed in comparison with this case.
authors.affiliation: Department of Gastroenterology, Niigata City General Hospital, Japan.
authors.forename: Kentarou
authors.initials: K
authors.lastname: Igarashi
authors.forename: Masahiro
authors.initials: M
authors.lastname: Hayashi
authors.forename: Munehiro
authors.initials: M
authors.lastname: Sato
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Aiba
authors.forename: Osamu
authors.initials: O
authors.lastname: Yoneyama
authors.forename: Nobuo
authors.initials: N
authors.lastname: Waguri
authors.forename: Kouichi
authors.initials: K
authors.lastname: Furukawa
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Sugimura
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Shibuya
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000008:administration & dosage; D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002945:Cisplatin / Q000008:administration & dosage; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005971:Glutamates / Q000008:administration & dosage; D006147:Guanine / Q000008:administration & dosage / Q000031:analogs & derivatives; D006801:Humans; D008297:Male; D008654:Mesothelioma / Q000188:drug therapy*; D008875:Middle Aged; D017239:Paclitaxel / Q000627:therapeutic use*; D000068437:Pemetrexed; D010534:Peritoneal Neoplasms / Q000188:drug therapy*; D000093542:Gemcitabine
chemical_list: D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D005971:Glutamates; D000068437:Pemetrexed; D003841:Deoxycytidine; D006147:Guanine; D017239:Paclitaxel; D002945:Cisplatin; D000093542:Gemcitabine