title: Cortical dysplasia: a possible substrate for brain tumors.
abstract: The similarities between brain tumor stem cells and neural stem cells suggest a possible stem cell origin of tumorigenesis. Recently, cells with features of stem cells have been observed in lesions of adult and pediatric cortical dysplasia (CD). Given the evidence for a close relationship between CD and certain brain tumors, together with the finding that CD neural stem cells/progenitors are abnormally developed, we propose that CD is a possible substrate for brain tumors. The neural stem cells/progenitors in CD have accumulating abnormalities, and these abnormal stem/progenitor cells may be the initiating, transformed cells of brain tumors, when subsequently exposed to a carcinogen.
authors.affiliation: Epilepsy Center of the Neurosurgery Department, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, People's Republic of China.
authors.forename: Shiyong
authors.initials: S
authors.lastname: Liu
authors.forename: Chunqing
authors.initials: C
authors.lastname: Zhang
authors.forename: Haifeng
authors.initials: H
authors.lastname: Shu
authors.forename: Didier
authors.initials: D
authors.lastname: Wion
authors.forename: Hui
authors.initials: H
authors.lastname: Yang
mesh_terms: D001932:Brain Neoplasms / Q000473:pathology*; D002471:Cell Transformation, Neoplastic; D006801:Humans; D054220:Malformations of Cortical Development / Q000473:pathology*; D014411:Neoplastic Stem Cells / Q000166:cytology / Q000473:pathology; D058953:Neural Stem Cells / Q000166:cytology / Q000473:pathology