title: Recent advances and applications of iridium-catalysed asymmetric allylic substitution.
abstract: Since their discovery in 1997, iridium-catalysed asymmetric allylic substitutions have been developed into a broadly applicable tool for the synthesis of chiral building blocks via C-C and C-heteroatom bond formation. The remarkable generality of these reactions and the high levels of regio- and enantioselectivity that are usually obtained in favour of the branched products have been made possible by a thorough investigation of the catalyst system and its mode of action. Therefore, today the Ir-catalysed asymmetric allylic substitution is a powerful reaction in the organic chemist's repertoire and has been used extensively for several applications. This article aims to provide an overview of the development of iridium catalysts derived from an Ir salt and a chiral phosphoramidite and their application to the enantioselective synthesis of natural products and biologically relevant compounds.
authors.affiliation: School of Chemistry, University of Leeds, Leeds, LS2 9JT, UK. paolo.tosatti@unibas.ch
authors.forename: Paolo
authors.initials: P
authors.lastname: Tosatti
authors.forename: Adam
authors.initials: A
authors.lastname: Nelson
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Marsden
mesh_terms: D000498:Allyl Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D001688:Biological Products / Q000138:chemical synthesis / Q000737:chemistry; D002384:Catalysis; D007495:Iridium / Q000737:chemistry*; D009943:Organophosphorus Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000498:Allyl Compounds; D001688:Biological Products; D009943:Organophosphorus Compounds; C434331:phosphoramidite; D007495:Iridium