title: Myocardial involvement in patients with osteogenesis imperfecta.
abstract: Mitral and aortic valve regurgitation is commonly found in osteogenesis imperfecta (OI) patients, however, little is known about the myocardial involvement in this disorder. An 82-year-old man with OI developed heart failure and was admitted to our hospital. Echocardiogram revealed severe mitral regurgitation without left ventricular (LV) dilatation, but with LV wall thickening. Histological analysis exhibited interstitial fibrosis of the myocardium in addition to myxoid changes of the mitral leaflet. These findings suggest that OI patients may develop LV remodeling together with diastolic dysfunction.
authors.affiliation: Department of Cardiovascular Medicine, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan.
authors.forename: Katsura
authors.initials: K
authors.lastname: Soma
authors.forename: Hajime
authors.initials: H
authors.lastname: Abe
authors.forename: Norihiko
authors.initials: N
authors.lastname: Takeda
authors.forename: Yukako
authors.initials: Y
authors.lastname: Shintani
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Takazawa
authors.forename: Toshiya
authors.initials: T
authors.lastname: Kojima
authors.forename: Katsuhito
authors.initials: K
authors.lastname: Fujiu
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Semba
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yamashita
authors.forename: Yasunobu
authors.initials: Y
authors.lastname: Hirata
authors.forename: Masashi
authors.initials: M
authors.lastname: Fukayama
authors.forename: Ryozo
authors.initials: R
authors.lastname: Nagai
mesh_terms: D000369:Aged, 80 and over; D005355:Fibrosis; D006801:Humans; D008297:Male; D009206:Myocardium / Q000473:pathology*; D010013:Osteogenesis Imperfecta / Q000473:pathology*