title: Clinical evaluation of the performance and safety of a new dentine substitute, Biodentine, in the restoration of posterior teeth - a prospective study.
abstract: OBJECTIVE
  A multicentric randomized, 3-year prospective study was conducted to determine for how long Biodentine, a new biocompatible dentine substitute, can remain as a posterior restoration.
  
  
  METHODS
  First, Biodentine was compared to the composite Z100®, to evaluate whether and for how long it could be used as a posterior restoration according to selected United States Public Health Service (USPHS)' criteria (mean ± SD). Second, when abrasion occurred, Biodentine was evaluated as a dentine substitute combined with Z100®.
  
  
  RESULTS
  A total of 397 cases were included. This interim analysis was conducted on 212 cases that were seen for the 1-year recall. On the day of restoration placement, both materials obtained good scores for material handling, anatomic form (0.12 ± 0.33), marginal adaptation (0.01 ± 0.10) and interproximal contact (0.11 ± 0.39). During the follow-up, both materials scored well in surface roughness (≤1) without secondary decay and post-operative pain. Biodentine kept acceptable surface properties regarding anatomic form score (≤1), marginal adaptation score (≤2) and interproximal contact score (≤1) for up to 6 months after placement. Resistance to marginal discoloration was superior with Biodentine compared to Z100®. When Biodentine was retained as a dentine substitute after pulp vitality control, it was covered systematically with the composite Z100®. This procedure yielded restorations that were clinically sound and symptom free.
  
  
  CONCLUSIONS
  Biodentine is able to restore posterior teeth for up to 6 months. When subsequently covered with Z100®, it is a convenient, efficient and well tolerated dentine substitute.
  
  
  CONCLUSIONS
  Biodentine as a dentine substitute can be used under a composite for posterior restorations.
authors.affiliation: Service d'Odontologie Gaston Berger, CHU de Marseille, 17-19 boulevard Mireille Lauze, 13010, Marseille, France.
authors.forename: Gilles
authors.initials: G
authors.lastname: Koubi
authors.forename: Pierre
authors.initials: P
authors.lastname: Colon
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Franquin
authors.forename: Aline
authors.initials: A
authors.lastname: Hartmann
authors.forename: Gilles
authors.initials: G
authors.lastname: Richard
authors.forename: Marie-Odile
authors.initials: MO
authors.lastname: Faure
authors.forename: Grégory
authors.initials: G
authors.lastname: Lambert
mesh_terms: D000328:Adult; D001672:Biocompatible Materials / Q000737:chemistry / Q000592:standards*; D001732:Bite Force; D017610:Calcium Compounds / Q000737:chemistry / Q000592:standards*; D003116:Color; D003188:Composite Resins / Q000737:chemistry; D003731:Dental Caries / Q000517:prevention & control; D003737:Dental Cavity Preparation / Q000145:classification; D018772:Dental Marginal Adaptation; D003764:Dental Materials / Q000737:chemistry / Q000592:standards*; D019232:Dental Restoration Failure; D058250:Dental Restoration Repair; D019554:Dental Restoration Wear; D003793:Dental Restoration, Permanent / Q000145:classification / Q000592:standards*; D003804:Dentin / Q000033:anatomy & histology*; D003807:Dentin Sensitivity / Q000517:prevention & control; D005500:Follow-Up Studies; D006801:Humans; D011446:Prospective Studies; D057872:Pulp Capping and Pulpectomy Agents / Q000737:chemistry; D017640:Silicates / Q000737:chemistry / Q000592:standards*; D012822:Silicon Dioxide / Q000737:chemistry; D013499:Surface Properties; D015040:Zirconium / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D017610:Calcium Compounds; D003188:Composite Resins; D003764:Dental Materials; D057872:Pulp Capping and Pulpectomy Agents; D017640:Silicates; C083568:Z100 composite resin; C506393:tricalcium silicate; D012822:Silicon Dioxide; D015040:Zirconium