title: Lysosomal disorders associated with leukoencephalopathy.
abstract: Metachromatic leukodystrophy and Krabbe's disease are among the most widely recognized causes of leukodystrophy. However, white matter changes have been described in several other lysosomal storage disorders. These conditions are summarized and those associated with hypomyelination are reviewed in more detail.
authors.affiliation: Division of Child and Adolescent Neurology, Department of Neurology, Mayo Clinic, 200 First St. SW, Rochester, MN 55901, USA. renaud.deborah@mayo.edu
authors.forename: Deborah L
authors.initials: DL
authors.lastname: Renaud
mesh_terms: D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000150:complications / Q000175:diagnosis; D003711:Demyelinating Diseases / Q000150:complications / Q000473:pathology; D005645:Fucosidosis / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D016537:Gangliosidosis, GM1 / Q000150:complications / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D007965:Leukodystrophy, Globoid Cell / Q000150:complications* / Q000473:pathology / Q000628:therapy; D007966:Leukodystrophy, Metachromatic / Q000150:complications* / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D056784:Leukoencephalopathies / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism; D016464:Lysosomal Storage Diseases / Q000150:complications* / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D029461:Sialic Acid Storage Disease / Q000150:complications / Q000175:diagnosis / Q000473:pathology