title: Incidence and mortality of bullous pemphigoid in France.
abstract: A major increase in the incidence of BP has been recently reported in the United Kingdom. In addition, there are some controversies about the over-mortality of BP patients. The primary objective was to reevaluate the incidence of BP in France as compared with that we estimated 15 years ago. The secondary objective was to assess mortality of BP patients. BP incidence was retrospectively estimated from all BP cases diagnosed between January 2000 and December 2005 in three French regions with a total population of 3.858 million inhabitants. BP mortality was assessed from a prospective cohort accrued during the same time period. A total of 502 incident BP patients (mean age: 82.6±8.8 years) were identified. Overall estimated incidence was 21.7 cases per million persons per year (95%CI:19.8-23.7 cases per million persons per year), which is about 3-fold higher than the incidence that we estimated 15 years ago. In the population aged 70 years or above, BP incidence was 162 cases per million per year (95%CI:147-177 cases per million per year). The overall 1-year survival rate was 62% (95% CI: 56-67%). The risk of death for BP patients was more than six times greater than that for the general population (SMR:6.60; 95%CI:5.47-7.90). The incidence of BP in France has increased 3-fold in the last 15 years. BP is associated with high mortality.
authors.affiliation: Department of Dermatology, INSERM U905, Rouen University Hospital, University of Rouen, Rouen, France. Pascal.Joly@chu-rouen.fr
authors.forename: Pascal
authors.initials: P
authors.lastname: Joly
authors.forename: Sophie
authors.initials: S
authors.lastname: Baricault
authors.forename: Agnès
authors.initials: A
authors.lastname: Sparsa
authors.forename: Philippe
authors.initials: P
authors.lastname: Bernard
authors.forename: Christophe
authors.initials: C
authors.lastname: Bédane
authors.forename: Sophie
authors.initials: S
authors.lastname: Duvert-Lehembre
authors.forename: Philippe
authors.initials: P
authors.lastname: Courville
authors.forename: Pierre
authors.initials: P
authors.lastname: Bravard
authors.forename: Brigitte
authors.initials: B
authors.lastname: Rémond
authors.forename: Valérie
authors.initials: V
authors.lastname: Doffoel-Hantz
authors.forename: Jacques
authors.initials: J
authors.lastname: Bénichou
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D005260:Female; D005602:France; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D009026:Mortality; D010391:Pemphigoid, Bullous / Q000453:epidemiology* / Q000401:mortality*; D011446:Prospective Studies; D016896:Treatment Outcome