title: Efficient [5 + 1]-strategy for the assembly of 1,8-naphthyridin-4(1H)-ones by domino amination/conjugate addition reactions of 1-(2-chloropyridin-3-yl)prop-2-yn-1-ones with amines.
abstract: A facile synthetic approach for the synthesis of 1,8-naphthyridine-4(1H)-one derivatives via a catalyst free and Pd-supported tandem amination sequence is developed and described. In a case of aliphatic amines reaction proceeds in a catalyst free mode, however anilines demand Pd-supported reaction conditions.
authors.affiliation: Institut für Chemie, Universität Rostock, Albert-Einstein-Str. 3a, 18059 Rostock, Germany. viktor.iaroshenko@uni-rostock.de
authors.forename: Viktor O
authors.initials: VO
authors.lastname: Iaroshenko
authors.forename: Ingo
authors.initials: I
authors.lastname: Knepper
authors.forename: Muhammad
authors.initials: M
authors.lastname: Zahid
authors.forename: Rene
authors.initials: R
authors.lastname: Kuzora
authors.forename: Sergii
authors.initials: S
authors.lastname: Dudkin
authors.forename: Alexander
authors.initials: A
authors.lastname: Villinger
authors.forename: Peter
authors.initials: P
authors.lastname: Langer
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D000586:Amination; D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D007659:Ketones / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D009287:Naphthyridines / Q000138:chemical synthesis*; D010165:Palladium / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry*
chemical_list: D000480:Alkynes; D000588:Amines; D007659:Ketones; D009287:Naphthyridines; D011725:Pyridines; D010165:Palladium