title: 90Y-labeled tin fluoride colloid as a promising therapeutic agent: preparation, characterization, and biological study in rats.
abstract: In this study, tin fluoride colloid (SnF-c) was prepared, labeled with yttrium-90 ((90)Y), and characterized with respect to its physicochemical properties and biological behavior in an animal model. Particle size of SnF-c, at constant concentration of SnF(2), was dependent on pH, concentration of sodium fluoride (NaF), temperature, and time. The particle size of SnF-c decreased with an increase in NaF concentration and a decrease in reaction mixture pH. Radiolabeling yield of (90)Y-SnF-c at higher temperature increased and it was greater than 98% for the preparation at 95 °C. The (90)Y-SnF-c demonstrated high in vitro stability both in human serum and human synovial fluid at 37 °C up to 7 days. In vivo distribution studies in healthy male Wistar rats of (90)Y-SnF-c (particles <1 μm), following intravenous administration, revealed that the localization takes place preferably in the liver. The (90)Y-SnF-c (particles >1 μm) was well retained in the synovial space for 96 h after intra-articular injection, whereas leakage of (90)Y from the joint was 1.96% over this period. Because of high labeling yield and stability, (90)Y-SnF-c might be a promising agent for radiosynovectomy or therapy of liver malignancies.
authors.affiliation: Laboratory for Radioisotopes, Vinca Institute of Nuclear Sciences, University of Belgrade, Belgrade 11001, Serbia. drinaj@vinca.rs
authors.forename: Drina
authors.initials: D
authors.lastname: Jankovic
authors.forename: Sanja
authors.initials: S
authors.lastname: Vranjes-Djuric
authors.forename: Divna
authors.initials: D
authors.lastname: Djokic
authors.forename: Mirjana
authors.initials: M
authors.lastname: Markovic
authors.forename: Boris
authors.initials: B
authors.lastname: Ajdinovic
authors.forename: Ljiljana
authors.initials: L
authors.lastname: Jaukovic
authors.forename: Nadezda
authors.initials: N
authors.lastname: Nikolic
mesh_terms: D000818:Animals; D003102:Colloids; D008297:Male; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D051381:Rats; D017208:Rats, Wistar; D014002:Tin Fluorides / Q000737:chemistry* / Q000493:pharmacokinetics; D014018:Tissue Distribution; D015021:Yttrium Radioisotopes / Q000737:chemistry* / Q000493:pharmacokinetics
chemical_list: D003102:Colloids; D014002:Tin Fluorides; D015021:Yttrium Radioisotopes