title: Hippocampal shape analysis in Alzheimer's disease and frontotemporal lobar degeneration subtypes.
abstract: Hippocampal pathology is central to Alzheimer's disease (AD) and other forms of dementia such as frontotemporal lobar degeneration (FTLD). Autopsy studies have shown that certain hippocampal subfields are more vulnerable than others to AD and FTLD pathology, in particular the subiculum and cornu ammonis 1 (CA1). We conducted shape analysis of hippocampi segmented from structural T1 MRI images on clinically diagnosed dementia patients and controls. The subjects included 19 AD and 35 FTLD patients [13 frontotemporal dementia (FTD), 13 semantic dementia (SD), and 9 progressive nonfluent aphasia (PNFA)] and 21 controls. Compared to controls, SD displayed severe atrophy of the whole left hippocampus. PNFA and FTD also displayed atrophy on the left side, restricted to the hippocampal head in FTD. Finally, AD displayed most atrophy in left hippocampal body with relative sparing of the hippocampal head. Consistent with neuropathological studies, most atrophic deformation was found in CA1 and subiculum areas in FTLD and AD.
authors.affiliation: Department of Neurobiology, Care Sciences and Society, Karolinska Institute, Stockholm, Sweden. olof.lindberg@ki.se
authors.forename: Olof
authors.initials: O
authors.lastname: Lindberg
authors.forename: Mark
authors.initials: M
authors.lastname: Walterfang
authors.forename: Jeffrey C L
authors.initials: JC
authors.lastname: Looi
authors.forename: Nikolai
authors.initials: N
authors.lastname: Malykhin
authors.forename: Per
authors.initials: P
authors.lastname: Ostberg
authors.forename: Bram
authors.initials: B
authors.lastname: Zandbelt
authors.forename: Martin
authors.initials: M
authors.lastname: Styner
authors.forename: Beatriz
authors.initials: B
authors.lastname: Paniagua
authors.forename: Dennis
authors.initials: D
authors.lastname: Velakoulis
authors.forename: Eva
authors.initials: E
authors.lastname: Orndahl
authors.forename: Lars-Olof
authors.initials: LO
authors.lastname: Wahlund
mesh_terms: D000328:Adult; D000368:Aged; D000544:Alzheimer Disease / Q000473:pathology*; D001284:Atrophy / Q000473:pathology; D056547:CA1 Region, Hippocampal / Q000473:pathology; D056651:CA2 Region, Hippocampal / Q000473:pathology; D056654:CA3 Region, Hippocampal / Q000473:pathology; D003704:Dementia / Q000473:pathology; D018891:Dentate Gyrus / Q000473:pathology; D005260:Female; D057174:Frontotemporal Lobar Degeneration / Q000473:pathology*; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D057178:Primary Progressive Nonfluent Aphasia / Q000473:pathology