title: The G894T polymorphism on endothelial nitric oxide synthase gene is associated with increased coronary heart disease among Asia population: evidence from a Meta analysis.
abstract: BACKGROUND
  Growing studies have revealed the underlying association between eNOS 894G/T (rs1799983) polymorphism and coronary heart disease (CHD) among Asia population. Results from these studies remained conflicting. We conducted this meta-analysis to estimate the overall CHD risk of eNOS 894G/T polymorphism regarding Asia population.
  
  
  METHODS
  Up to October 2011, databases including PubMed, Embase and CNKI (China National Knowledge Infrastructure) were searched to access the relevant genetic association studies. Summary odds ratios and corresponding 95% confidence intervals (CIs) for eNOS 894G/T polymorphism and CHD risk were estimated using fixed or random-effects models when appropriate.
  
  
  RESULTS
  18 case-control studies with 2,994 cases and 3,130 controls were available for this study, including 13 studies of East-Asia descendents, 5 studies of Non East-Asian descendents. The mean T allele frequency was 0.111 in the East-Asia population and 0.147 in the Non East-Asia population, respectively. The summary OR for CHD associated with the T allele was 1.52 (95% confidence intervals (95%CI), 1.37-1.69) by random effects model. Similarly, significantly increased risks were observed in the East-Asia population (OR=1.54; 95%CI=1.35-1.76) and in the Non East-Asia population (OR=1.48; 95%CI=1.24-1.77), respectively.
  
  
  CONCLUSIONS
  This meta-analysis indicated that eNOS 894G/T polymorphism may play an important role in CHD development among Asia population.
authors.affiliation: Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan 610041, PR China.
authors.forename: Kui
authors.initials: K
authors.lastname: Zhang
authors.forename: Peng
authors.initials: P
authors.lastname: Bai
authors.forename: Shaoqing
authors.initials: S
authors.lastname: Shi
authors.forename: Bin
authors.initials: B
authors.lastname: Zhou
authors.forename: Yanyun
authors.initials: Y
authors.lastname: Wang
authors.forename: Yaping
authors.initials: Y
authors.lastname: Song
authors.forename: Li
authors.initials: L
authors.lastname: Rao
authors.forename: Lin
authors.initials: L
authors.lastname: Zhang
mesh_terms: D001208:Asia / Q000453:epidemiology; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D003327:Coronary Disease / Q000453:epidemiology / Q000235:genetics*; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D052250:Nitric Oxide Synthase Type III / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide
chemical_list: C496314:NOS3 protein, human; D052250:Nitric Oxide Synthase Type III