title: Immunomodulatory effects of antimicrobial agents. Part I: antibacterial and antiviral agents.
abstract: Despite impressive therapeutic progresses in the battle against infections, microorganisms are still a threat to mankind. With hundreds of antibacterial molecules, major concerns remain about the emergence of resistant and multidrug-resistant pathogens. On the other hand, the antiviral drug armamentarium is comprised of only a few dozens of compounds which are highly pathogen specific, and resistance is also a concern. According to Arturo Casadevall (Albert Einstein College of Medicine, NY, USA), we have now entered the third era of anti-infective strategy, which intends to favor the interplay between active molecules and the immune system. The first part of this review focuses on the potential immunomodulating properties of anti-infective agents, beginning with antibacterial and antiviral agents.
authors.affiliation: Inserm SC14 Centre d'Expertise Collective, Université Paris Diderot Paris, 7 Faculté de Médecine Site Bichat, 16 rue Henri Huchard, 75890, Paris Cedex 18, France. marie-therese.labro@inserm.fr
authors.forename: Marie-Thérèse
authors.initials: MT
authors.lastname: Labro
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000276:immunology* / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000009:adverse effects / Q000276:immunology / Q000627:therapeutic use; D000998:Antiviral Agents / Q000009:adverse effects / Q000276:immunology* / Q000627:therapeutic use; D001424:Bacterial Infections / Q000188:drug therapy* / Q000276:immunology; D002648:Child; D006801:Humans; D007107:Immune System / Q000187:drug effects; D007155:Immunologic Factors / Q000009:adverse effects / Q000276:immunology* / Q000627:therapeutic use; D014777:Virus Diseases / Q000188:drug therapy* / Q000276:immunology
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000998:Antiviral Agents; D007155:Immunologic Factors