title: Inhibition of Cu-amyloid-β by using bifunctional peptides with β-sheet breaker and chelator moieties.
abstract: Breaking the mold: Inhibition of toxic amyloid-β (Aβ) aggregates and disruption of Cu-Aβ with subsequent redox-silencing of Cu have been considered promising strategies against Alzheimer's disease. The design and proof of concept of simple peptides containing a Cu-chelating/redox-silencing unit and an Aβ-aggregation inhibition unit (β-sheet breaker) is described (see scheme).
authors.affiliation: CNRS, Laboratoire de Chimie de Coordination, Toulouse, 31077, France.
authors.forename: Madeleine
authors.initials: M
authors.lastname: Jensen
authors.forename: Anne
authors.initials: A
authors.lastname: Canning
authors.forename: Sabri
authors.initials: S
authors.lastname: Chiha
authors.forename: Pierre
authors.initials: P
authors.lastname: Bouquerel
authors.forename: Jeppe Trudslev
authors.initials: JT
authors.lastname: Pedersen
authors.forename: Jesper
authors.initials: J
authors.lastname: Østergaard
authors.forename: Olivier
authors.initials: O
authors.lastname: Cuvillier
authors.forename: Isabelle
authors.initials: I
authors.lastname: Sasaki
authors.forename: Christelle
authors.initials: C
authors.lastname: Hureau
authors.forename: Peter
authors.initials: P
authors.lastname: Faller
mesh_terms: D000595:Amino Acid Sequence; D000682:Amyloid / Q000037:antagonists & inhibitors* / Q000737:chemistry* / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000037:antagonists & inhibitors* / Q000737:chemistry* / Q000378:metabolism; D002614:Chelating Agents / Q000737:chemistry* / Q000494:pharmacology; D003300:Copper / Q000737:chemistry* / Q000494:pharmacology; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010084:Oxidation-Reduction; D010446:Peptide Fragments / Q000378:metabolism; D011485:Protein Binding; D017433:Protein Structure, Secondary
chemical_list: D000682:Amyloid; D016229:Amyloid beta-Peptides; D002614:Chelating Agents; D010446:Peptide Fragments; D003300:Copper