title: Investigation of angiogenetic pathways in nasal polyposis.
abstract: Tissue angiogenesis is a complex phenomenon that results in the growth of new blood vessels from the microcirculation. This process has been known to play a crucial role in tumor growth as well as several benign diseases. The aim of this study was to assess mRNA expression of various angiogenic factors and chemokines in nasal polyps and compare the results to normal nasal mucosa. mRNA expression was measured using real-time RT-PCR for the following angiogenic factors and chemokines: VEGF, VEGFR-1, Ang-1, Ang-2, Tie-2A, Tie-2B, SDF-1α, SDF-1β, CXCR4 and YY1. Biopsy specimens from nasal polyps in the polyposis group and middle turbinates in the control group were studied. A total of 18 nasal polyposis patients were studied and compared to 10 control subjects. Results showed VEGF, VEGFR-1, Ang-1, Ang-2, Tie-2A, Tie-2B, SDF-1α and SDF-1β mRNA expression to be significantly higher in nasal polyposis patients compared to the control group (p<0.05). The findings of this study support the role of angiogenic growth factors in the pathogenesis of nasal polyposis. Further studies are required to confirm these results and evaluate potential clinical implications.
authors.affiliation: Laboratory of Molecular and Cellular Pulmonary Medicine, Medical School, University of Crete, Heraklion, Crete, Greece.
authors.forename: Alexandros D
authors.initials: AD
authors.lastname: Karatzanis
authors.forename: Katerina D
authors.initials: KD
authors.lastname: Samara
authors.forename: Katerina M
authors.initials: KM
authors.lastname: Antoniou
authors.forename: Rena
authors.initials: R
authors.lastname: Lymbouridou
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Chatzakis
authors.forename: Demetrios A
authors.initials: DA
authors.lastname: Spandidos
authors.forename: Georgios A
authors.initials: GA
authors.lastname: Velegrakis
authors.forename: Nikolaos M
authors.initials: NM
authors.lastname: Siafakas
mesh_terms: D000328:Adult; D016207:Cytokines / Q000096:biosynthesis*; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D009389:Neovascularization, Pathologic / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D012333:RNA, Messenger / Q000096:biosynthesis*
chemical_list: D016207:Cytokines; D012333:RNA, Messenger