title: Blood pressure measurements in a transgenic SOD1-G93A mouse model of amyotrophic lateral sclerosis.
abstract: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by progressive loss of motor neurons, but non-motor manifestations including autonomic dysfunction have been reported. To better understand the autonomic involvement in ALS we measured blood pressure (BP) changes. We evaluated blood pressure (BP) in a transgenic (TG) SOD1-G93A mouse model of ALS. BP was recorded in awake mice from six to 19 weeks of age by the tail-cuff method. TG mice (n =15) had significantly elevated BP compared to their wild-type (WT) siblings (n =14) even prior to the clinical appearance of motor dysfunction (at age 10-11 weeks, p =0.026). BP gradually decreased in TG mice but not in WT mice from age 10-11 weeks until the advanced stages of the disease (p for trend <0.002). The results indicate impairment of cardiovascular control in this ALS model.
authors.affiliation: The Department of Physiology and Pharmacology, Sackler School of Medicine, Tel-Aviv University and the Department of Neurology, Tel-Aviv Medical Centre, Israel.
authors.forename: Boris
authors.initials: B
authors.lastname: Kandinov
authors.forename: Vivian E
authors.initials: VE
authors.lastname: Drory
authors.forename: Karen
authors.initials: K
authors.lastname: Tordjman
authors.forename: Amos D
authors.initials: AD
authors.lastname: Korczyn
mesh_terms: D000367:Age Factors; D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics* / Q000503:physiopathology*; D000704:Analysis of Variance; D000818:Animals; D001794:Blood Pressure / Q000235:genetics* / Q000502:physiology; D001835:Body Weight / Q000235:genetics; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009069:Movement Disorders / Q000209:etiology / Q000235:genetics; D013482:Superoxide Dismutase / Q000235:genetics*
chemical_list: C109415:SOD1 G93A protein; D013482:Superoxide Dismutase