title: Acetylation: a novel link between double-strand break repair and autophagy.
abstract: Histone deacetylase (HDAC) inhibitors are clinically relevant because they are used as anticancer drugs. Recent evidence sheds light on an intriguing connection among the DNA damage response (DDR), protein acetylation, and autophagy. HDAC inhibitors have been shown to counteract key steps in the cellular response to double-strand break formation by affecting checkpoint activation, homologous recombination-mediated repair of DNA lesions, and stability of crucial enzymes involved in resection of DNA ends. The degradation of the resection factors depends on autophagy, which plays a detrimental role when cells are in a hyperacetylated state and experience treatment with radiomimetic anticancer drugs. Future work will be required to further investigate the mechanisms underlying the link between acetylation, autophagy, and the DDR, as well as the significance of mTORC1 inhibitors, which are potent inducers of autophagy that are now used in cancer treatment.
authors.affiliation: Fondazione Istituto FIRC di Oncologia Molecolare, Milan, Italy.
authors.forename: Ghadeer
authors.initials: G
authors.lastname: Shubassi
authors.forename: Thomas
authors.initials: T
authors.lastname: Robert
authors.forename: Fabio
authors.initials: F
authors.lastname: Vanoli
authors.forename: Saverio
authors.initials: S
authors.lastname: Minucci
authors.forename: Marco
authors.initials: M
authors.lastname: Foiani
mesh_terms: D000107:Acetylation; D001343:Autophagy; D053903:DNA Breaks, Double-Stranded; D004260:DNA Repair; D004791:Enzyme Inhibitors / Q000494:pharmacology; D056572:Histone Deacetylase Inhibitors / Q000494:pharmacology; D006801:Humans; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000378:metabolism; D014635:Valproic Acid / Q000494:pharmacology
chemical_list: D004791:Enzyme Inhibitors; D056572:Histone Deacetylase Inhibitors; D014635:Valproic Acid