title: Immunotherapy approaches targeting regulatory T-cells.
abstract: The immune system prevents establishment and progression of cancer through innate and adaptive surveillance. However, some cancerous cells successfully evade the immune system. Regulatory T-cells (Tregs) facilitate such evasion. Tregs may be the factor responsible for the limited success of human tumor immunotherapy to date. To improve immunotherapy, it is thought that the number of Tregs and their functions should be inhibited in patients with advanced cancer. In this review, we focus on recent immunotherapy efforts targeting Tregs.
authors.affiliation: Department of Cancer Therapy and Research, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan. ohnishi@surg1.med.kyushu-u.ac.jp
authors.forename: Hideya
authors.initials: H
authors.lastname: Onishi
authors.forename: Takashi
authors.initials: T
authors.lastname: Morisaki
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Katano
mesh_terms: D006801:Humans; D007167:Immunotherapy; D009369:Neoplasms / Q000276:immunology / Q000628:therapy; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*