title: Responsive hydrogels for label-free signal transduction within biosensors.
abstract: Hydrogels have found wide application in biosensors due to their versatile nature. This family of materials is applied in biosensing either to increase the loading capacity compared to two-dimensional surfaces, or to support biospecific hydrogel swelling occurring subsequent to specific recognition of an analyte. This review focuses on various principles underpinning the design of biospecific hydrogels acting through various molecular mechanisms in transducing the recognition event of label-free analytes. Towards this end, we describe several promising hydrogel systems that when combined with the appropriate readout platform and quantitative approach could lead to future real-life applications.
authors.affiliation: Biophysics and Medical Technology, Department of Physics, The Norwegian University of Science and Technology, NTNU NO-7491 Trondheim, Norway. kamila.gawel@ntnu.no
authors.forename: Kamila
authors.initials: K
authors.lastname: Gawel
authors.forename: David
authors.initials: D
authors.lastname: Barriet
authors.forename: Marit
authors.initials: M
authors.lastname: Sletmoen
authors.forename: Bjørn Torger
authors.initials: BT
authors.lastname: Stokke
mesh_terms: D015374:Biosensing Techniques; D020100:Hydrogels / Q000737:chemistry*; D013194:Staining and Labeling; D014159:Transducers
chemical_list: D020100:Hydrogels