title: Gating neural development and aging via nuclear pores.
abstract: Emerging evidence suggests an involvement of nuclear pore components in the regulation of neural differentiation and aging. These findings will have far-ranging impacts on the understanding of the function of the nuclear envelope in physiological settings and in various neurological diseases.
authors.affiliation: National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China. ghliu@ibp.ac.cn
authors.forename: Guang-Hui
authors.initials: GH
authors.lastname: Liu
authors.forename: Mo
authors.initials: M
authors.lastname: Li
authors.forename: Jing
authors.initials: J
authors.lastname: Qu
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Izpisua Belmonte
mesh_terms: D000818:Animals; D016922:Cellular Senescence; D051379:Mice; D055495:Neurogenesis; D009474:Neurons / Q000378:metabolism / Q000502:physiology*; D009569:Nitric Oxide / Q000378:metabolism; D009685:Nuclear Envelope / Q000378:metabolism / Q000502:physiology; D022022:Nuclear Pore / Q000378:metabolism / Q000502:physiology*; D028861:Nuclear Pore Complex Proteins / Q000378:metabolism; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D028861:Nuclear Pore Complex Proteins; C512902:Nup210 protein, mouse; D017382:Reactive Oxygen Species; D009569:Nitric Oxide