title: Sexual function in breast cancer patients: a prospective study from Iran.
abstract: BACKGROUND
  Sexual function in patients with breast cancer especially in younger patients is an important issue from clinical and psychosocial perspectives. This study aimed to assess sexual function among Iranian breast cancer patients.
  
  
  METHODS
  This was a prospective study of sexual function in breast cancer patients attending the Cancer Institute of Iran. Sexual function was assessed using the Female Sexual Function Index (FSFI) at two points in time: baseline (pre-treatment) and after completion of cancer treatment at follow-up visits (post-treatment). Pre- and post-treatment data were compared. In addition logistic regression analysis was performed to find out factors that contributing to post-treatment sexual dysfunction.
  
  
  RESULTS
  In all 277 breast cancer patients were approached. Of these, 231 patients (83%) were sexually active and data for 216 patients (93.5% of sexually active patients) were available at pre-and post-treatment. Overall pre- and post-treatment sexual dysfunction was found to be 52% and 84%, respectively indicating a significant deterioration in sexual function among breast cancer patients. The results obtained from multiple logistic regression analysis indicated that younger age [OR = 0.95, 95% CI = 0.93-0.98; P = 0.04], receiving endocrine therapy [OR = 3.34, 95% CI = 1.37-7.91; P = 0.007] and poor sexual function at pre-treatment [OR = 12.3, 95% CI = 3.93-39.0; P < 0.0001] were the most significant contributing factors to post-treatment sexual disorders.
  
  
  CONCLUSIONS
  A significant number of breast cancer patients experience deterioration in sexual function over time. The findings from this study indicated that younger age, receiving endocrine therapy, and poor sexual function at diagnosis were the most significant predicting factors for sexual disorders following treatment.
authors.affiliation: Cancer Research Centre, Cancer Institute of Iran, Tehran University of Medical Sciences, Tehran, Iran. harirchi@sina.tums.ac.ir
authors.forename: Iraj
authors.initials: I
authors.lastname: Harirchi
authors.forename: Ali
authors.initials: A
authors.lastname: Montazeri
authors.forename: Fereshteh
authors.initials: F
authors.lastname: Zamani Bidokhti
authors.forename: Nina
authors.initials: N
authors.lastname: Mamishi
authors.forename: Kazem
authors.initials: K
authors.lastname: Zendehdel
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000503:physiopathology* / Q000628:therapy; D005260:Female; D006801:Humans; D007492:Iran; D008875:Middle Aged; D011446:Prospective Studies; D011788:Quality of Life; D012725:Sexual Behavior; D011795:Surveys and Questionnaires; D055815:Young Adult