title: Neonatal outcomes are associated with latency after preterm premature rupture of membranes.
abstract: OBJECTIVE
  To determine factors associated with latency time to birth after preterm premature rupture of membranes (PPROM) and the impact on neonatal outcomes.
  
  
  METHODS
  Data on singleton pregnancies with PPROM (n=1535 infants) were prospectively collected in a computerized perinatal/neonatal database at a tertiary care perinatal center. Latency was characterized as ≤72h versus >72 h after PPROM.
  
  
  RESULTS
  The percentage of women with latency to birth >72 h decreased from 67% in very preterm (gestational age (GA) 25 to 28 weeks) to 10% in late preterm women (GA 33 to 36 weeks). PPROM women with latency ≤72 h were more likely to have pregnancy-induced hypertension and birth weight <3%; PPROM women with latency >72 h were more likely to have received steroids and develop clinical chorioamnionitis. PPROM <32 weeks GA with latency ≤72 h was associated with a two-fold higher incidence of severe neonatal morbidity, while PPROM between 29 to 34 weeks GA and latency ≤72 h was associated with a higher incidence of moderate neonatal morbidity.
  
  
  CONCLUSIONS
  A latency period >72 h was associated with a decreased incidence of adverse neonatal outcomes up to 32 weeks GA for severe and 34 weeks GA for moderate morbidity indices.
authors.affiliation: Department of Obstetrics and Gynaecology, Children Health Research Institute, University of Western Ontario, London, ON, Canada.
authors.forename: D
authors.initials: D
authors.lastname: Nayot
authors.forename: D
authors.initials: D
authors.lastname: Penava
authors.forename: O
authors.initials: O
authors.lastname: Da Silva
authors.forename: B S
authors.initials: BS
authors.lastname: Richardson
authors.forename: B
authors.initials: B
authors.lastname: de Vrijer
mesh_terms: D000328:Adult; D001724:Birth Weight; D015984:Causality; D002657:Child Development; D015331:Cohort Studies; D015897:Comorbidity; D016208:Databases, Factual; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology; D005500:Follow-Up Studies; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000453:epidemiology*; D007234:Infant, Premature; D007363:Intensive Care Units, Neonatal; D008297:Male; D007752:Obstetric Labor, Premature / Q000453:epidemiology; D011247:Pregnancy; D011256:Pregnancy Outcome; D018570:Risk Assessment; D013997:Time Factors