title: A naphthalene exciplex based Al3+ selective on-type fluorescent probe for living cells at the physiological pH range: experimental and computational studies.
abstract: 2-((Naphthalen-6-yl)methylthio)ethanol (HL) was prepared by one pot synthesis using 2-mercaptoethanol and 2-bromomethylnaphthalene. It was found to be a highly selective fluorescent sensor for Al(3+) in the physiological pH (pH 7.0-8.0). It could sense Al(3+) bound to cells through fluorescence microscopy. Metal ions like Mn(2+), Fe(3+), Co(2+), Ni(2+), Cu(2+), Zn(2+), Ag(+), Cd(2+), Hg(2+), Cr(3+) and Pb(2+) did not interfere. No interference was also observed with anions like Cl(-), Br(-), F(-), SO(4)(2-), NO(3)(-), CO(3)(2-), HPO(4)(2-) and SCN(-). Experimentally observed structural and spectroscopic features of HL and its Al(3+) complex have been substantiated by computational calculations using density functional theory (DFT) and time dependent density functional theory (TDDFT).
authors.affiliation: Department of Chemistry, The University of Burdwan, Burdwan 713104, India.
authors.forename: Arnab
authors.initials: A
authors.lastname: Banerjee
authors.forename: Animesh
authors.initials: A
authors.lastname: Sahana
authors.forename: Sudipta
authors.initials: S
authors.lastname: Das
authors.forename: Sisir
authors.initials: S
authors.lastname: Lohar
authors.forename: Subarna
authors.initials: S
authors.lastname: Guha
authors.forename: Bidisha
authors.initials: B
authors.lastname: Sarkar
authors.forename: Subhra Kanti
authors.initials: SK
authors.lastname: Mukhopadhyay
authors.forename: Asok K
authors.initials: AK
authors.lastname: Mukherjee
authors.forename: Debasis
authors.initials: D
authors.lastname: Das
mesh_terms: D000535:Aluminum / Q000737:chemistry*; D002176:Candida albicans / Q000166:cytology; D002470:Cell Survival; D019281:Dimerization; D005456:Fluorescent Dyes / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008958:Models, Molecular; D008968:Molecular Conformation; D009281:Naphthalenes / Q000737:chemistry*; D011789:Quantum Theory; D012995:Solubility; D014867:Water / Q000737:chemistry
chemical_list: D005456:Fluorescent Dyes; D009281:Naphthalenes; D014867:Water; C031721:naphthalene; D000535:Aluminum