title: Breast carcinomas with hyperprolactinemia at the time of diagnosis-clinico-biological association.
abstract: OBJECTIVE
  To analyse association between preoperative hyperprolactinemia serum levels and clinical and biological features of breast tumors.
  
  
  METHODS
  Serum levels of prolactin were measured in 253 women with invasive breast cancer. Clinical and biological parameters analysed were age, size, lymph node involvement, distant metastasis and immunohistochemical expression of estrogen receptor, progesterone receptor, androgen receptor, bcl-2, p53 and Ki67.
  
  
  RESULTS
  In ductal carcinomas hyperprolactinemia were associated with high age (p = 0.017), and with bcl-2 + + + expression (p = 0.017). Furthermore, serum prolactin values were significantly higher in bcl-2 +++ cases vs negative (p = 0.029); the same happened when we considered the positivity threshold of 25 ng/mL (p = 0.015).
  
  
  CONCLUSIONS
  Is possible to detect in 6% of infiltrating ductal breast carcinomas hyperprolactinemia (>25 ng/mL), being associated only with increasing age, but not with other clinical or biological factors; and 2) the most surprising data was the association between prolactinemia (qualitative (>25 ng/mL) and quantitative) and intense bcl-2 tissue expression, which suggests that, probably, this (prolactinemia) is not a sign of worse prognosis and evolution.
authors.affiliation: Molecular Oncology and Imaging Program, Complejo Hospitalario Universitario, Santiago de Compostela, A Coruña, Spain. michel.herranz.carnero@sergas.es
authors.forename: M
authors.initials: M
authors.lastname: Herranz
authors.forename: M
authors.initials: M
authors.lastname: Pombo
authors.forename: P
authors.initials: P
authors.lastname: Menendez-Rodriguez
authors.forename: J I
authors.initials: JI
authors.lastname: Arias
authors.forename: A
authors.initials: A
authors.lastname: Ruibal
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood / Q000378:metabolism; D001943:Breast Neoplasms / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D018270:Carcinoma, Ductal, Breast / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood / Q000150:complications*; D008875:Middle Aged; D011379:Prognosis; D011388:Prolactin / Q000097:blood*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D011944:Receptors, Androgen / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D019253:Proto-Oncogene Proteins c-bcl-2; D011944:Receptors, Androgen; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D011388:Prolactin