title: [Case of pneumonitis caused by Yokukansan].
abstract: A 74-year-old man was admitted to our hospital complaining of severe neck pain and general fatigue. He had been undergoing treatment for post-operative neck pain at the out-patient clinic of our hospital, but was now complaining of pain more intense than usual. Chest X-rays revealed diffuse ground glass shadows in bilateral lung fields, and computed tomography revealed diffuse intestinal shadows. A drug lymphocyte stimulation test (DLST) was also performed at that time. Steroid pulse therapy improved the clinical symptoms, hypoxemia and chest X-ray findings. DLST performed again with Yokukansan and Hachimijiogan 133 days after the initial diagnosis of pneumonitis showed Yokukansan was positive. This result showed Yukukansan may be a causative drug for allergic drug-induced pneumonitis. Any drugs including kanpo may be possible to induce allergic pneumonitis.
authors.affiliation: Department of Anesthesiology, Juntendo Tokyo Koto Geriatric Medical Center Tokyo 136-0075.
authors.forename: Kanna
authors.initials: K
authors.lastname: Nakamura
authors.forename: Toshiko
authors.initials: T
authors.lastname: Shimizu
authors.forename: Hiromasa
authors.initials: H
authors.lastname: Mitsuhata
mesh_terms: D000368:Aged; D000542:Alveolitis, Extrinsic Allergic / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D004365:Drugs, Chinese Herbal / Q000009:adverse effects*; D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage; D020551:Pulse Therapy, Drug; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D004365:Drugs, Chinese Herbal; C524644:Yi-Gan San; D008775:Methylprednisolone