title: Epigallocatechin-3-gallate (EGCG) enhances the therapeutic activity of a dental adhesive.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the antibacterial potential and physicochemical properties of a dental adhesive incorporated with epigallocatechin-3-gallate (EGCG) in different concentration over time.
  
  
  METHODS
  EGCG was incorporated at a ratio of 100, 200, and 300 μg/ml into a dental adhesive. The effects of the cured adhesives on the growth of Streptococcus mutans were determined by direct contact test immediately or one month later and by scanning electron microscopy (SEM), respectively. Microtensile bond strength (μTBS) test was used to test the mechanical property of the adhesives immediately or six months later. The degree of conversion (DC) of the adhesives was evaluated by Fourier transform infrared spectroscopy (FTIR).
  
  
  RESULTS
  Compared with negative control, the 200 μg/ml and 300 μg/ml EGCG-incorporated dental adhesive were found to exhibit inhibitory effect on the growth of S. mutans. The μTBS of the EGCG-incorporated dental adhesive was higher than the control. The DC of the adhesive system was not affected by the addition of EGCG.
  
  
  CONCLUSIONS
  200 μg/ml EGCG incorporated dental adhesives could accomplish therapeutic goals that play in antimicrobial function whilst keeping the durability of resin-dentine bond.
authors.affiliation: The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology, Wuhan University, Wuhan, People's Republic of China.
authors.forename: Xijin
authors.initials: X
authors.lastname: Du
authors.forename: Xueqing
authors.initials: X
authors.lastname: Huang
authors.forename: Cui
authors.initials: C
authors.lastname: Huang
authors.forename: Yake
authors.initials: Y
authors.lastname: Wang
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects; D002392:Catechin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D055598:Chemical Phenomena; D003188:Composite Resins / Q000737:chemistry; D001840:Dental Bonding; D003738:Dental Cements / Q000737:chemistry*; D003764:Dental Materials / Q000737:chemistry; D003804:Dentin / Q000648:ultrastructure; D006801:Humans; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D058105:Polymerization; D017550:Spectroscopy, Fourier Transform Infrared; D013295:Streptococcus mutans / Q000187:drug effects; D013314:Stress, Mechanical; D013499:Surface Properties; D013696:Temperature; D013718:Tensile Strength; D013997:Time Factors; D014867:Water / Q000737:chemistry
chemical_list: C554641:Adper single bond 2; D000900:Anti-Bacterial Agents; D000975:Antioxidants; C084111:Charisma composite resin; D003188:Composite Resins; D003738:Dental Cements; D003764:Dental Materials; D014867:Water; D002392:Catechin; C045651:epigallocatechin gallate