title: PET and MRI for the evaluation of regional myocardial perfusion and wall thickening after myocardial infarction.
abstract: BACKGROUND
  Deterioration of left ventricular (LV) function after myocardial infarction (MI) is a major cause of heart failure. Myocardial perfusion performance may play an important role in deterioration or improvement in LV function after MI. The aim of this study was to evaluate the myocardial perfusion reserve (MPR) and stress perfusion in deteriorating and non-deteriorating LV segments in patients after MI by PET and MRI, respectively.
  
  
  METHODS
  Regional wall thickening of 352 segments in 22 patients was assessed at 4 and 24 months after MI by cardiac MRI. PET was performed to evaluate MPR and adenosine stress (13)N-ammonia perfusion 24 months after MI. Segments were divided into four groups according to deterioration or improvement in wall thickening.
  
  
  RESULTS
  Normal functional segments at 4 months after MI that remained stable had a significantly higher mean MPR and mean stress perfusion PET value than deteriorated segments (p < 0.001). Furthermore, dysfunctional segments that improved had a significantly higher mean stress perfusion PET value than dysfunctional segments that remained dysfunctional (p < 0.001).
  
  
  CONCLUSIONS
  This study demonstrated the additional value of myocardial perfusion assessment in relation to the functional integrity of the injured myocardium. Segmental functional LV improvement after MI was associated with better regional myocardial perfusion characteristics. Furthermore, the amount of wall thickening reduction was associated with regional myocardial perfusion abnormalities in patients after MI.
authors.affiliation: Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, Hanzeplein 1, PO Box 30001, 9700 RB Groningen, The Netherlands. r.h.j.a.slart@umcg.nl
authors.forename: Riemer H J A
authors.initials: RH
authors.lastname: Slart
authors.forename: Julius
authors.initials: J
authors.lastname: Glauche
authors.forename: Reza
authors.initials: R
authors.lastname: Golestani
authors.forename: Clark J
authors.initials: CJ
authors.lastname: Zeebregts
authors.forename: Jan W
authors.initials: JW
authors.lastname: Jansen
authors.forename: Rudi A J O
authors.initials: RA
authors.lastname: Dierckx
authors.forename: Matthijs
authors.initials: M
authors.lastname: Oudkerk
authors.forename: Tineke P
authors.initials: TP
authors.lastname: Willems
authors.forename: Andor W J M
authors.initials: AW
authors.lastname: Glaudemans
authors.forename: Hendrikus H
authors.initials: HH
authors.lastname: Boersma
authors.forename: René A
authors.initials: RA
authors.lastname: Tio
mesh_terms: D000241:Adenosine / Q000494:pharmacology; D003326:Coronary Circulation / Q000187:drug effects; D003331:Coronary Vessels / Q000000981:diagnostic imaging / Q000187:drug effects / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000473:pathology* / Q000503:physiopathology*; D049268:Positron-Emission Tomography; D012039:Regional Blood Flow / Q000187:drug effects; D012189:Retrospective Studies; D013312:Stress, Physiological / Q000187:drug effects; D016896:Treatment Outcome
chemical_list: D000241:Adenosine