title: Recombinant human PDGF-BB in foot and ankle fusion.
abstract: Autogenous bone graft (autograft) is currently the gold standard for augmenting bone repair and fusion procedures of the foot and ankle. The time, cost and morbidity involved in obtaining autograft, however, are well documented and legitimate concerns remain surrounding this intervention. Endogenous human PDGF is chemotactic and mitogenic for osteoblasts and undifferentiated osteoprogenitor cells, and upregulates expression of cytokines necessary for osseous and soft tissue healing and regeneration. The BB isoform of PDGF, and the biosynthetic replica recombinant human PDGF-BB, is a key regulatory molecule in bone homeostasis, repair and regeneration. When combined with a β-tricalcium phosphate osteoconductive matrix, recombinant human PDGF-BB mitigates a number of problems associated with the use of autograft and, based on its preclinical performance and early clinical success, appears to be an equally effective and perhaps an even safer alternative to autograft for foot and ankle fusion (arthrodesis) procedures.
authors.affiliation: Department of Orthopedic Surgery, The Warren Alpert School of Medicine at Brown University, Rhode Island Hospital, 593 Eddy Street, Providence, RI 02903, USA. christopher_digiovanni@brown.edu
authors.forename: Christopher W
authors.initials: CW
authors.lastname: DiGiovanni
authors.forename: Sheldon
authors.initials: S
authors.lastname: Lin
authors.forename: Michael
authors.initials: M
authors.lastname: Pinzur
mesh_terms: D000842:Ankle / Q000601:surgery*; D000077214:Becaplermin; D002130:Calcium Phosphates / Q000494:pharmacology; D005528:Foot / Q000601:surgery*; D006801:Humans; D019637:Orthopedic Procedures / Q000379:methods*; D020574:Proto-Oncogene Proteins c-sis / Q000494:pharmacology*; D011994:Recombinant Proteins / Q000494:pharmacology*
chemical_list: D002130:Calcium Phosphates; D020574:Proto-Oncogene Proteins c-sis; D011994:Recombinant Proteins; C485817:beta-tricalcium phosphate; D000077214:Becaplermin