title: [The relationship between glycogen synthase kinase-3 beta (GSK3B) -50T/C -1727A/T polymorphisms and alcoholism].
abstract: As a help of the mechanism elucidation of alcoholism, we studied the relationship between glycogen synthase kinase 3-beta (GSK3B) -50T/C and -1727A/T polymorphisms, which are reported to relate to bipolar disorder. We genotyped the two polymorphisms in GSK3B gene using a polymerase chain reaction (PCR) in 71 health controls and 47 alcoholics. In this study, there was no significant difference in the frequency of GSK3B -50T/C and -1727A/T polymorphisms between alcoholics and controls. We suggested that there was no significant association of GSK3B -50T/C and -1727A/T polymorphisms with alcoholism.
authors.affiliation: Laboratory of Neurophysiology, the Graduate School of Environmental, Health Sciences, Azabu University, 1-17-71 Fuchinobe, Chuo-ku, Sagamihara-shi, Kanagawa 252-5201, Japan.
authors.forename: Eiji
authors.initials: E
authors.lastname: Yoshihara
authors.forename: Jun
authors.initials: J
authors.lastname: Aoki
authors.forename: Kouhei
authors.initials: K
authors.lastname: Kurihara
authors.forename: Maki
authors.initials: M
authors.lastname: Numajiri
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Iwahashi
mesh_terms: D000437:Alcoholism / Q000235:genetics*; D005260:Female; D038362:Glycogen Synthase Kinase 3 / Q000235:genetics*; D000071679:Glycogen Synthase Kinase 3 beta; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
chemical_list: C000605506:GSK3B protein, human; D000071679:Glycogen Synthase Kinase 3 beta; D038362:Glycogen Synthase Kinase 3