title: Application of nanosized MCM-41 to fabrication of a nanostructured electrochemical sensor for the simultaneous determination of levodopa and carbidopa.
abstract: A novel carbon paste electrode modified with nanosized mesoporous MCM-41 was prepared, and used as an electrochemical sensor to study the electro oxidation of levodopa (LD), carbidopa (CD) and their mixtures. Using differential pulse voltammetry (DPV), a highly selective and simultaneous determination of LD and CD has been explored at the modified electrode. The electrochemical sensor displayed a good resolving function for the overlapping voltammetric responses of LD and CD into two separate peaks with a potential difference of 370 mV. DPV peak currents of LD increased linearly with concentration over the 0.13 μM to 1250.00 μM range and exhibited a detection limit of 0.072 μM. Also, the proposed electrochemical sensor was used for the determination of LD and CD in some real samples, using the standard addition method.
authors.affiliation: Department of Chemistry, Faculty of Science, Yazd University, Yazd, 89195-741, I.R. Iran. mazloum@yazduni.ac.ir
authors.forename: Mohammad
authors.initials: M
authors.lastname: Mazloum-Ardakani
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Sheikh-Mohseni
authors.forename: Mohammad
authors.initials: M
authors.lastname: Abdollahi-Alibeik
authors.forename: Ali
authors.initials: A
authors.lastname: Benvidi
mesh_terms: D002138:Calibration; D002230:Carbidopa / Q000032:analysis*; D055664:Electrochemical Techniques / Q000295:instrumentation*; D004566:Electrodes; D007980:Levodopa / Q000032:analysis*; D057230:Limit of Detection; D008855:Microscopy, Electron, Scanning; D049329:Nanostructures; D014961:X-Ray Diffraction
chemical_list: D007980:Levodopa; D002230:Carbidopa