title: WTX: an unexpected regulator for p53.
abstract: The WTX gene is frequently lost or mutated in Wilms tumor. In this issue of Molecular Cell, Kim et al. (2012) identify WTX modulation of p53 tumor-suppressor activity through regulation of p53 acetylation. Therefore, WTX differentially regulates the oncogenic β-catenin pathway and the tumor-suppressing p53 pathway.
authors.affiliation: Institute for Cancer Genetics, College of Physicians and Surgeons, Columbia University, 1130 Saint Nicholas Avenue, New York, NY 10032, USA.
authors.forename: Chao
authors.initials: C
authors.lastname: Dai
authors.forename: Wei
authors.initials: W
authors.lastname: Gu