title: [Early effects of enalapril in patients with chronic cerebral ischemia and arterial hypertension].
abstract: The study included 56 patients with chronic cerebral ischemia and arterial hypertension. Protective effect of enalapril (enap) on endothelium was apparent as increased fibrinolytic activity of plasma, decreased platelet aggregation amplitude caused by adrenalin and ristocetin, partial restoration of endothelium-dependent vasodilation, and inhibition of Willebrand factor release in the arteriovenous occlusion test. The degree of reduction of neurologic deficit by enalapril correlated with the decrease in Willebrand factor release.
mesh_terms: D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002545:Brain Ischemia / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D002908:Chronic Disease; D004334:Drug Administration Schedule; D004656:Enalapril / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000473:pathology; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D008875:Middle Aged; D016896:Treatment Outcome; D014841:von Willebrand Factor / Q000037:antagonists & inhibitors / Q000096:biosynthesis
chemical_list: D000959:Antihypertensive Agents; D014841:von Willebrand Factor; D004656:Enalapril