title: Pegfilgrastim- versus filgrastim-based autologous hematopoietic stem cell mobilization in the setting of preemptive use of plerixafor: efficacy and cost analysis.
abstract: BACKGROUND
  Plerixafor enhances the ability of filgrastim (FIL) to mobilize CD34+ cells but adds cost to the mobilization. We hypothesized that replacing weight-based FIL with flat-dose pegfilgrastim (PEG) in a validated cost-based mobilization algorithm for patient-adapted use of plerixafor would add convenience without increased cost.
  
  
  METHODS
  A single-center retrospective analysis compared two consecutive cohorts undergoing FIL or PEG mobilization before autologous hematopoietic stem cell transplantation for multiple myeloma or lymphoma. FIL dose was 10 µg/kg/day continuing until completion of collection and a 12-mg flat dose of PEG. Peripheral blood CD34+ cells (PB-CD34+) enumeration was performed on the fourth day after initiation of growth factor. Subjects surpassing a certain target-specific threshold of PB-CD34+ started apheresis immediately while subjects with lower PB-CD34+ received plerixafor with apheresis starting on the fifth day.
  
  
  RESULTS
  Overall 68 of 74 in the FIL group and 52 of 57 patients in the PEG group met the mobilization target. Only one patient in each cohort required remobilization. Median PB-CD34+ on Day 4 was significantly higher in patients in the PEG group (18.1×10(6) vs. 28.7×10(6)cells/L, p=0.01). Consequently, patients in the PEG group were less likely to require administration of plerixafor (67.5% vs. 45.6%, p=0.01). Cohorts had near identical mean number of apheresis sessions and comparable CD34+ yield. The estimated cost associated with growth factor was higher in patients in the PEG group, but it was counterbalanced by lower cost associated with use of plerixafor.
  
  
  CONCLUSIONS
  Single administration of 12 mg of PEG is associated with better CD34+ mobilization than FIL allowing for effective, convenient mobilization with less frequent use of plerixafor.
authors.affiliation: Department of Medicine, Division of Hematology and Oncology, Medical University of South Carolina, Charleston, South Carolina 29425-6350, USA. costalj@musc.edu
authors.forename: Luciano J
authors.initials: LJ
authors.lastname: Costa
authors.forename: Cindy
authors.initials: C
authors.lastname: Kramer
authors.forename: Kathy R
authors.initials: KR
authors.lastname: Hogan
authors.forename: Coleen D
authors.initials: CD
authors.lastname: Butcher
authors.forename: Amanda L
authors.initials: AL
authors.lastname: Littleton
authors.forename: Katie B
authors.initials: KB
authors.lastname: Shoptaw
authors.forename: Yubin
authors.initials: Y
authors.lastname: Kang
authors.forename: Robert K
authors.initials: RK
authors.lastname: Stuart
mesh_terms: D000328:Adult; D000368:Aged; D019380:Anti-HIV Agents / Q000191:economics / Q000627:therapeutic use; D001596:Benzylamines; D001781:Blood Component Removal / Q000191:economics; D003362:Cost-Benefit Analysis; D000080027:Cyclams; D016527:Drug Costs; D005260:Female; D000069585:Filgrastim; D016179:Granulocyte Colony-Stimulating Factor / Q000191:economics / Q000627:therapeutic use*; D019650:Hematopoietic Stem Cell Mobilization / Q000191:economics / Q000379:methods*; D006571:Heterocyclic Compounds / Q000191:economics / Q000627:therapeutic use*; D006801:Humans; D008223:Lymphoma / Q000188:drug therapy* / Q000191:economics; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000188:drug therapy* / Q000191:economics; D011092:Polyethylene Glycols; D011994:Recombinant Proteins / Q000191:economics / Q000627:therapeutic use; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D019380:Anti-HIV Agents; D001596:Benzylamines; D000080027:Cyclams; D006571:Heterocyclic Compounds; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; C455861:pegfilgrastim; D011092:Polyethylene Glycols; D000069585:Filgrastim; C088327:plerixafor