title: Survival and neurodevelopmental outcome of ELBW children at 5 years of age: comparison of two cohorts born 10 years apart.
abstract: OBJECTIVE
  To examine survival and outcome of extremely low-birth-weight (ELBW) children (birth weight < 1000 g) in two 5-year periods, 10 years apart.
  
  
  METHODS
  In a retrospective population-based study, information on all ELBW children born in Iceland in 1991-1995 and in 2001-2005 was obtained from the National Birth Registry, hospital charts and medical records. The two periods were compared.
  
  
  RESULTS
  In 1991-1995, 102 of 22.261 newborn children (0.5%) were extremely low birth weight compared with 70 of 20.923 newborns (0.33%) in 2001-2005 (p = 0.04). At 5 years of age, 52% (35/67) of live-born children born in 1991-1995 were alive compared with 63% (31/49) of children born in 2001 - 2005 (p = 0.2). Six ELBW children (17%) born 1991-1995 were diagnosed with disabilities at 5 years of age, three with major neurodevelopmental disabilities compared with six (19%) born 2001-2005, thereof one with severe neurodevelopmental disabilities (p = 0.57).
  
  
  CONCLUSIONS
  The incidence of childhood disabilities in ELBW children in Iceland remains stable despite an increase in survival rate. The severity of neurodevelopmental disabilities has decreased.
authors.affiliation: Faculty of Medicine, The University of Iceland, Saemundargata, Reykjavik, Iceland.
authors.forename: Gudrun Maria
authors.initials: GM
authors.lastname: Jonsdottir
authors.forename: Ingibjorg
authors.initials: I
authors.lastname: Georgsdottir
authors.forename: Asgeir
authors.initials: A
authors.lastname: Haraldsson
authors.forename: Hildur
authors.initials: H
authors.lastname: Hardardottir
authors.forename: Thordur
authors.initials: T
authors.lastname: Thorkelsson
authors.forename: Atli
authors.initials: A
authors.lastname: Dagbjartsson
mesh_terms: D001766:Blindness / Q000453:epidemiology*; D002547:Cerebral Palsy / Q000453:epidemiology*; D046688:Child Mortality; D002675:Child, Preschool; D015331:Cohort Studies; D002658:Developmental Disabilities / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007055:Iceland / Q000453:epidemiology; D015994:Incidence; D007226:Infant Mortality; D052577:Infant, Extremely Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000453:epidemiology*; D008607:Intellectual Disability / Q000453:epidemiology*; D008297:Male; D011379:Prognosis; D012042:Registries; D012189:Retrospective Studies; D012720:Severity of Illness Index; D015996:Survival Rate