title: Ectopic fat is linked to prior cardiovascular events in men with HIV.
abstract: Epicardial Adipose Tissue (EAT) has been associated with adverse cardiovascular events in the general population. We studied the association of general adiposity measures (body mass index, waist circumference) and ectopic adipose tissue [visceral adipose tissue (VAT); liver fat (LF); EAT) with prevalent cardiovascular disease (CVD) (prior myocardial infarction, coronary revascularization, stroke, peripheral vascular disease] in 583 HIV-infected men. VAT, EAT, and LF (liver/spleen attenuation ratio < 1.1) were measured by computed tomography. Patients' mean age was 48.5 ± 8.1 years, prior CVD was present in 33 (5.7%) patients. Factors independently associated with CVD on multivariable analyses were age [incidence-rate ratio (IRR) = 1.07, 95% confidence interval (CI): 1.02 to 1.12], smoking (IRR = 2.70, 95% CI: 1.22 to 6.01), Center for Disease Control group C (IRR = 3.09, 95% CI: 1.41 to 6.76), EAT (IRR = 1.13, 95% CI: 1.04 to 1.24, per 10 cm), LF (IRR = 1.17, 95% CI: 1.04 to 1.32), and VAT (IRR = 1.05, 95% CI: 1.00 to 1.10, per 10 cm). Ectopic fat but not general adiposity measures were associated with prevalent CVD in men with HIV.
authors.affiliation: Department of Medicine and Medical Specialties, University of Modena and Reggio Emilia, Modena, Italy.
authors.forename: Gabriella
authors.initials: G
authors.lastname: Orlando
authors.forename: Orlando
authors.initials: O
authors.lastname: Gabriella
authors.forename: Giovanni
authors.initials: G
authors.lastname: Guaraldi
authors.forename: Guaraldi
authors.initials: G
authors.lastname: Giovanni
authors.forename: Stefano
authors.initials: S
authors.lastname: Zona
authors.forename: Zona
authors.initials: Z
authors.lastname: Stefano
authors.forename: Federica
authors.initials: F
authors.lastname: Carli
authors.forename: Carli
authors.initials: C
authors.lastname: Federica
authors.forename: Pietro
authors.initials: P
authors.lastname: Bagni
authors.forename: Bagni
authors.initials: B
authors.lastname: Pietro
authors.forename: Marianna
authors.initials: M
authors.lastname: Menozzi
authors.forename: Menozzi
authors.initials: M
authors.lastname: Marianna
authors.forename: Stefania
authors.initials: S
authors.lastname: Cocchi
authors.forename: Cocchi
authors.initials: C
authors.lastname: Stefania
authors.forename: Riccardo
authors.initials: R
authors.lastname: Scaglioni
authors.forename: Scaglioni
authors.initials: S
authors.lastname: Riccardo
authors.forename: Guido
authors.initials: G
authors.lastname: Ligabue
authors.forename: Ligabue
authors.initials: L
authors.lastname: Guido
authors.forename: Paolo
authors.initials: P
authors.lastname: Raggi
authors.forename: Raggi
authors.initials: R
authors.lastname: Paolo
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000328:Adult; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000150:complications / Q000453:epidemiology*; D003430:Cross-Sectional Studies; D015658:HIV Infections / Q000150:complications*; D039682:HIV-Associated Lipodystrophy Syndrome / Q000150:complications* / Q000000981:diagnostic imaging; D006801:Humans; D050152:Intra-Abdominal Fat / Q000000981:diagnostic imaging / Q000378:metabolism; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012189:Retrospective Studies; D012307:Risk Factors; D014057:Tomography, X-Ray Computed; D055105:Waist Circumference / Q000502:physiology