title: Premature luteal regression in a pregnant mare and subsequent pregnancy maintenance with the use of oral altrenogest.
abstract: Premature luteal demise or luteal insufficiency is not well characterised as a cause of pregnancy loss in domestic species, including horses. In this report, a mare inseminated with cooled-transported semen at our facility returned for a routine pregnancy diagnosis at 15 days post ovulation. Ultrasonography per rectum revealed endometrial oedema and the absence of visual indication of a corpus luteum on either ovary. Nonetheless, an embryonic vesicle small for the gestational age was identified. Daily oral altrenogest treatment was implemented immediately. Serum progesterone concentration was 0.67 ng/ml, which is below the threshold considered adequate for pregnancy maintenance in the mare. Examinations were repeated at 17, 25, 30, 39, 49, 72 and 120 days post ovulation. At 25 days post ovulation the embryonic vesicle presented normal development for the gestational age. In addition, sequential blood samples were collected to measure progesterone, equine chorionic gonadotrophin and oestrone sulphate concentrations. Although progesterone concentration did not exceed 2 ng/ml until 72 days post ovulation, all other results were unremarkable and a healthy filly was born uneventfully at 344 days post ovulation.
authors.affiliation: Section of Theriogenology, Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, New York, NY, USA.
authors.forename: I F
authors.initials: IF
authors.lastname: Canisso
authors.forename: K A
authors.initials: KA
authors.lastname: Beltaire
authors.forename: S J
authors.initials: SJ
authors.lastname: Bedford-Guaus
mesh_terms: D000034:Abortion, Veterinary / Q000517:prevention & control; D000284:Administration, Oral; D000818:Animals; D006063:Chorionic Gonadotropin / Q000097:blood; D003340:Corpus Luteum Maintenance / Q000187:drug effects*; D004970:Estrone / Q000031:analogs & derivatives / Q000097:blood; D005260:Female; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D014204:Trenbolone Acetate / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D006063:Chorionic Gonadotropin; C112940:Progest; D004970:Estrone; C023445:altrenogest; D011374:Progesterone; C017296:estrone sulfate; D014204:Trenbolone Acetate