title: Laparoscopic Nissen-Rossetti fundoplication for gastroesophageal reflux disease patients after 2-year follow-up.
abstract: BACKGROUND
  Gastroesphageal reflux disease (GERD) is a common condition in the general population, affecting patients' quality of life and predisposing to Barrett's esophagus and its most fearsome complication, esophageal adenocarcinoma. The aim of this study is to compare objective and subjective outcomes of laparoscopic Nissen-Rossetti fundoplication after 2 years of follow-up.
  
  
  METHODS
  Seventy-six GERD patients underwent laparoscopic Nissen-Rossetti fundoplication. Patients were subjected to close follow-up.
  
  
  RESULTS
  The DeMeester and Johnson score average decreased from a mean preoperative value of 35.48 (SD±40.24) to 9.83 (SD±6.40) at 6 months; at 12 months it was 11.44 (SD±10.28), and at 24 months it was 10.25 (SD±5.61). GERD Health-Related Quality of Life decreased from a preoperative value of 23.04 (SD±11.59) to 9.84 (SD±8.98) at 6 months, 8.34 (SD±8.98) at 12 months, and 6.8 (SD±6.46) at 24 months. The Short Form-36 measurement showed significant improvement.
  
  
  CONCLUSIONS
  GERD patients need adequate reflux control. Successful antireflux surgery is more effective than medical therapy in preventing both acid and bile reflux. Surgical therapy is effective in terms of reflux control and improvement in quality of life. Strict and rigorous follow-up with both subjective and objective tests is important in order to identify asymptomatic recurrence of reflux after surgery.
authors.affiliation: Referral Center for the Surgical Treatment of Gastroesophageal Reflux Diseases, Department of Surgery F. Durante, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
authors.forename: Salvatore
authors.initials: S
authors.lastname: Marano
authors.forename: Stefano
authors.initials: S
authors.lastname: Mattacchione
authors.forename: Barbara
authors.initials: B
authors.lastname: Luongo
authors.forename: Valentina
authors.initials: V
authors.lastname: Mingarelli
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Campagna
authors.forename: Francesco
authors.initials: F
authors.lastname: Vietri
authors.forename: Filippo
authors.initials: F
authors.lastname: Tosato
mesh_terms: D000328:Adult; D000368:Aged; D001471:Barrett Esophagus / Q000150:complications; D003680:Deglutition Disorders / Q000209:etiology / Q000601:surgery; D004940:Esophageal Stenosis / Q000209:etiology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D018662:Fundoplication / Q000009:adverse effects; D005764:Gastroesophageal Reflux / Q000150:complications / Q000175:diagnosis / Q000601:surgery*; D006551:Hernia, Hiatal / Q000150:complications / Q000000981:diagnostic imaging; D006801:Humans; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D011788:Quality of Life; D011859:Radiography; D012086:Reoperation; D055502:Secondary Prevention; D016896:Treatment Outcome