title: Lack of significant variability among different methods for calculating antimicrobial days of therapy.
abstract: Days of therapy (DOTs) are an important measure to quantify antimicrobial use but may not reflect patients' true antimicrobial exposure. Three methods of calculating DOTs were compared to determine whether including "exposure days," when antimicrobials are given less frequently than daily due to renal dysfunction, makes a difference.
authors.affiliation: Department of Pharmacy, NewYork-Presbyterian Hospital, New York, New York, USA. cck27@columbia.edu
authors.forename: Christine J
authors.initials: CJ
authors.lastname: Kubin
authors.forename: Haomiao
authors.initials: H
authors.lastname: Jia
authors.forename: Luis R
authors.initials: LR
authors.lastname: Alba
authors.forename: E
authors.initials: E
authors.lastname: Yoko Furuya
mesh_terms: D000328:Adult; D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D002443:Ceftriaxone / Q000008:administration & dosage / Q000627:therapeutic use; D054796:Drug Dosage Calculations; D006801:Humans; D007674:Kidney Diseases / Q000378:metabolism; D015242:Ofloxacin / Q000008:administration & dosage / Q000627:therapeutic use; D010397:Penicillanic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use; D010878:Piperacillin / Q000008:administration & dosage / Q000627:therapeutic use; D000077725:Piperacillin, Tazobactam Drug Combination; D013997:Time Factors; D014031:Tobramycin / Q000008:administration & dosage / Q000627:therapeutic use; D014640:Vancomycin / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D000890:Anti-Infective Agents; D000077725:Piperacillin, Tazobactam Drug Combination; D014640:Vancomycin; D002443:Ceftriaxone; D010397:Penicillanic Acid; D015242:Ofloxacin; D014031:Tobramycin; D010878:Piperacillin