title: Growth factor-mediated combination therapy to treat large local human alveolar ridge defects.
abstract: The purpose of this case report is to demonstrate the effectiveness of a matrix consisting of recombinant human platelet-derived growth factor BB (rhPDGF-BB)-hydrated cancellous allogenic block graft in the reconstruction of large local human alveolar ridge defects. The results suggest improved bone regeneration when combining rhPDGF-BB with the allogenic block graft. The clinical and histologic evidence of new bone formation as well as bone remodeling supports the clinical potency of this growth factor-mediated therapy.
authors.affiliation: Division of Periodontology, Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, 188 Longwood Avenue, Boston, MA 02115, USA. nevinsperimp@aol.com
authors.forename: Myron
authors.initials: M
authors.lastname: Nevins
authors.forename: Marcelo
authors.initials: M
authors.lastname: Camelo
authors.forename: Marc L
authors.initials: ML
authors.lastname: Nevins
authors.forename: Daniel K
authors.initials: DK
authors.lastname: Ho
authors.forename: Peter
authors.initials: P
authors.lastname: Schupbach
authors.forename: David M
authors.initials: DM
authors.lastname: Kim
mesh_terms: D000540:Alveolar Ridge Augmentation / Q000379:methods*; D043925:Angiogenesis Inducing Agents / Q000627:therapeutic use*; D000077214:Becaplermin; D001706:Biopsy; D015519:Bone Density / Q000502:physiology; D001861:Bone Regeneration / Q000502:physiology; D016723:Bone Remodeling / Q000502:physiology; D016025:Bone Transplantation / Q000379:methods* / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D008437:Maxilla / Q000473:pathology / Q000601:surgery; D010012:Osteogenesis / Q000502:physiology; D059745:Piezosurgery; D020574:Proto-Oncogene Proteins c-sis / Q000627:therapeutic use*; D011994:Recombinant Proteins; D019651:Plastic Surgery Procedures / Q000379:methods*; D014057:Tomography, X-Ray Computed
chemical_list: D043925:Angiogenesis Inducing Agents; D020574:Proto-Oncogene Proteins c-sis; D011994:Recombinant Proteins; D000077214:Becaplermin