title: Nutrient intakes and the common mental disorders in women.
abstract: BACKGROUND
  There is an increasing recognition of the role of nutrition in depression and anxiety. Magnesium, folate and zinc have all been implicated in depressive illness, however there are few data on these nutrients in anxiety disorders and the data from population-studies are limited.
  
  
  OBJECTIVE
  In a large, randomly-selected, population-based sample of women, this study aimed to examine the relationship between the dietary intakes of these three micronutrients and clinically determined depressive and anxiety disorders and symptoms.
  
  
  METHODS
  Nutrient intakes were determined using a validated food frequency questionnaire. The General Health Questionnaire-12 measured psychological symptoms, and a clinical interview (Structured Clinical Interview for DSM-IV-TR, non-patient edition) assessed current depressive and anxiety disorders.
  
  
  RESULTS
  After adjustments for energy intake, each standard deviation increase in the intake of zinc, magnesium and folate was associated with reduced odds ratio (OR) for major depression/dysthymia (zinc: OR=0.52, 95% confidence interval (CI) 0.31 to 0.88; magnesium: OR=0.60, 95% CI 0.37 to 0.96; folate: OR=0.66, 95% CI 0.45 to 0.97). There was also an inverse association between the intake of magnesium and zinc and GHQ-12 scores (zinc: zβ=-0.16, 95% CI -0.29 to -0.04; magnesium: -0.14, 95% CI -0.26 to -0.03). These relationships were not confounded by age, socioeconomic status, education or other health behaviours. There was no relationship observed between any nutrient and anxiety disorders.
  
  
  CONCLUSIONS
  These results demonstrate an association between the dietary intakes of magnesium, folate and zinc and depressive illnesses, although reverse causality and/or confounding cannot be ruled out as explanations.
authors.affiliation: Barwon Psychiatric Research Unit, School of Medicine, Deakin University, Australia. felice@barwonhealth.org.au
authors.forename: Felice N
authors.initials: FN
authors.lastname: Jacka
authors.forename: Michael
authors.initials: M
authors.lastname: Maes
authors.forename: Julie A
authors.initials: JA
authors.lastname: Pasco
authors.forename: Lana J
authors.initials: LJ
authors.lastname: Williams
authors.forename: Michael
authors.initials: M
authors.lastname: Berk
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001008:Anxiety Disorders / Q000097:blood; D003865:Major Depressive Disorder / Q000097:blood*; D004032:Diet; D015930:Diet Records; D005260:Female; D005492:Folic Acid / Q000097:blood*; D006801:Humans; D008274:Magnesium / Q000097:blood*; D018977:Micronutrients / Q000097:blood; D008875:Middle Aged; D009752:Nutritional Status; D055815:Young Adult; D015032:Zinc / Q000097:blood*
chemical_list: D018977:Micronutrients; D005492:Folic Acid; D008274:Magnesium; D015032:Zinc