title: Impaired iron status in aging research.
abstract: Aging is associated with disturbances in iron metabolism and storage. During the last decade, remarkable progress has been made toward understanding their cellular and molecular mechanisms in aging and age-associated diseases using both cultured cells and animal models. The field has moved beyond descriptive studies to potential intervention studies focusing on iron chelation and removal. However, some findings remain controversial and inconsistent. This review summarizes important features of iron dyshomeostasis in aging research with a particular emphasis on current knowledge of the mechanisms underlying age-associated disorders in rodent models.
authors.affiliation: Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville, FL 32611, USA.
authors.forename: Jinze
authors.initials: J
authors.lastname: Xu
authors.affiliation: Biology Institute, Hebei Academy of Science, Shijiazhuang 050051, China.
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Jia
authors.affiliation: Food Science and Human Nutrition Department, University of Florida, Gainesville, FL 32611, USA.
authors.forename: Mitchell D
authors.initials: MD
authors.lastname: Knutson
authors.affiliation: Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville, FL 32611, USA.
authors.forename: Christiaan
authors.initials: C
authors.lastname: Leeuwenburgh
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D004195:Disease Models, Animal; D006304:Health Status; D006801:Humans; D007501:Iron / Q000378:metabolism*; D019189:Iron Metabolism Disorders / Q000209:etiology* / Q000378:metabolism; D008928:Mitochondria / Q000502:physiology; D012377:Rodentia
chemical_list: D007501:Iron