title: Independent evaluation of an in-house brachytherapy treatment planning system using simulation, measurement and calculation methods.
abstract: Accuracy of treatment planning systems may significantly influence the efficacy of brachytherapy. The purpose of this work is a detailed, varied and independent evaluation of an in-house brachytherapy treatment planning software called STPS. Operational accuracy of STPS was investigated. Geometric tests were performed to validate entry and reconstruction of positional information from scanned orthogonal films. MCNP4C Monte Carlo code and TLDs were used for simulation and experimental measurement, respectively. STPS data were also compared with those from a commercial planning system (Nucletron PLATO). Discrepancy values between MCNP and STPS data and also those of PLATO and STPS at Manchester system dose prescription points (AL and AR) of tandem and ovoid configurations were 2.5% ± 0.5% and 5.4% ± 0.4%, respectively. Similar results were achieved for other investigated configurations. Observed discrepancies between MCNP and STPS at the dose prescription point and at 1 cm from the tip of the vaginal applicator were 4.5% and 25.6% respectively, while the discrepancy between the STPS and PLATO data at those points was 2.3%. The software showed submillimeter accuracy in its geometrical reconstructions. In terms of calculation accuracy, similar to PLATO, as attenuation of the sources and applicator body is not considered, dose was overestimated at the tip of the applicator, but based on the available criteria, dose accuracy at most points were acceptable. Our results confirm STPS's geometrical and operational reliability, and show that its dose computation accuracy is comparable to an established commercial TPS using the same algorithm.
authors.affiliation: Center for Research in Medical Physics and Biomedical Engineering, Shiraz University of Medical Sciences, Shiraz, Iran.
authors.forename: M A
authors.initials: MA
authors.lastname: Mosleh Shirazi
authors.forename: R
authors.initials: R
authors.lastname: Faghihi
authors.forename: Z
authors.initials: Z
authors.lastname: Siavashpour
authors.forename: H A
authors.initials: HA
authors.lastname: Nedaie
authors.forename: S
authors.initials: S
authors.lastname: Mehdizadeh
authors.forename: S
authors.initials: S
authors.lastname: Sina
mesh_terms: D000465:Algorithms; D001918:Brachytherapy / Q000295:instrumentation*; D003198:Computer Simulation; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D009010:Monte Carlo Method; D019047:Phantoms, Imaging; D011859:Radiography; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D012984:Software; D002583:Uterine Cervical Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000532:radiotherapy*; D014867:Water / Q000737:chemistry
chemical_list: D014867:Water