title: Detection of genotoxic, cytotoxic, and protective activities of Eugenia dysenterica DC. (Myrtaceae) in mice.
abstract: Eugenia dysenterica DC. (Myrtaceae), popularly known in Brazil as cagaiteira, is a widespread plant species in the Brazilian Cerrado. In folk medicine, the leaves of this plant are used to treat diarrhea and dysentery. The fruits are used for fresh consumption and industrial purposes. Because of the use of this plant as a therapeutic resource and food, the present study evaluated the genotoxic, cytotoxic, antigenotoxic, and anticytotoxic effects of the lyophilized ethanolic leaf extract of E. dysenterica using the mouse bone marrow micronucleus test. The genotoxicity and antigenotoxicity of this extract were evaluated using the frequency of micronucleated polychromatic erythrocytes, and the cytotoxicity and anticytotoxicity were assessed by the polychromatic and normochromatic erythrocyte ratio. According to our results, the lyophilized ethanolic leaf extract of E. dysenterica exhibited genotoxic and cytotoxic effects at the higher doses and protection against cyclophosphamide-induced genotoxic and cytotoxic actions at all doses tested.
authors.affiliation: Department of General Biology, Institute of Biological Sciences, Federal University of Goiás , Goiânia, Goiás, Brazil. pablinebio@gmail.com
authors.forename: Pabline Marinho
authors.initials: PM
authors.lastname: Vieira
authors.forename: Eduardo
authors.initials: E
authors.lastname: Veronezi
authors.forename: Carolina R
authors.initials: CR
authors.lastname: Silva
authors.forename: Lee
authors.initials: L
authors.lastname: Chen-Chen
mesh_terms: D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D003520:Cyclophosphamide / Q000633:toxicity*; D003603:Cytotoxins / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects*; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D009153:Mutagens / Q000494:pharmacology; D010936:Plant Extracts / Q000009:adverse effects / Q000494:pharmacology*; D018515:Plant Leaves; D027842:Syzygium
chemical_list: D016587:Antimutagenic Agents; D003603:Cytotoxins; D009153:Mutagens; D010936:Plant Extracts; D003520:Cyclophosphamide