title: Pancreatic islet cell transplantation: an update for interventional radiologists.
abstract: Pancreatic islet cell transplantation is a promising cellular-based therapy for type 1 diabetes mellitus. This procedure involves portal venous injection of islet cells and affords 1-year insulin independence in as many as 80% of recipients. Although transplant surgeons represent historical drivers of islet therapy, requirement for image guidance and transcatheter techniques has fostered collaboration with interventional radiologists, who are positioned to play a significant role in clinical performance of islet transplantation and in basic science research in this field. This review article aims to familiarize interventional radiologists with islet cell transplantation patient selection, procedure technique, clinical outcomes, and future clinical and research avenues.
authors.affiliation: Department of Radiology, Interventional Radiology Section, University of Illinois Medical Center at Chicago, 1740 West Taylor St, MC 931, Chicago, IL 60612, USA. rgaba@uic.edu
authors.forename: Ron C
authors.initials: RC
authors.lastname: Gaba
authors.forename: Raquel
authors.initials: R
authors.lastname: Garcia-Roca
authors.forename: Jose
authors.initials: J
authors.lastname: Oberholzer
mesh_terms: D017690:Cell Transplantation / Q000009:adverse effects / Q000266:history / Q000379:methods*; D003922:Diabetes Mellitus, Type 1 / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000266:history / Q000601:surgery*; D005260:Female; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D016381:Islets of Langerhans Transplantation / Q000009:adverse effects / Q000266:history / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010690:Phlebography; D011169:Portal Vein / Q000000981:diagnostic imaging; D015641:Radiography, Interventional / Q000009:adverse effects / Q000266:history; D016896:Treatment Outcome; D018615:Ultrasonography, Doppler, Color; D018084:Ultrasonography, Interventional / Q000009:adverse effects / Q000266:history