title: Stem cells and regenerative medicine in lung biology and diseases.
abstract: A number of novel approaches for repair and regeneration of injured lung have developed over the past several years. These include a better understanding of endogenous stem and progenitor cells in the lung that can function in reparative capacity as well as extensive exploration of the potential efficacy of administering exogenous stem or progenitor cells to function in lung repair. Recent advances in ex vivo lung engineering have also been increasingly applied to the lung. The current status of these approaches as well as initial clinical trials of cell therapies for lung diseases are reviewed below.
authors.affiliation: Department of Genetics, Stem Cell Program, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: Allison N
authors.initials: AN
authors.lastname: Lau
authors.forename: Meagan
authors.initials: M
authors.lastname: Goodwin
authors.forename: Carla F
authors.initials: CF
authors.lastname: Kim
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Weiss
mesh_terms: D000818:Animals; D053595:Embryonic Stem Cells / Q000378:metabolism; D006801:Humans; D056747:Immunomodulation; D057026:Induced Pluripotent Stem Cells / Q000378:metabolism; D008168:Lung / Q000502:physiology*; D008171:Lung Diseases / Q000276:immunology / Q000628:therapy*; D059630:Mesenchymal Stem Cells; D014411:Neoplastic Stem Cells / Q000378:metabolism; D012038:Regeneration; D044968:Regenerative Medicine; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000378:metabolism*; D023822:Tissue Engineering