title: Antioxidant and lipoxygenase inhibiting new iridoid glucosides from Caryopteris odorata.
abstract: The phytochemical investigation of the ethylacetate-soluble fraction of Caryopteris odorata (Ham. ex Roxb.) led to the isolation of four new iridoid glucosides (1-4): 8-O-trans-cinnamoyl caryoptoside (1), 8-O-trans-cinnamoyl shanzhiside methylester (2), 8-O-trans-cinnamoyl mussaenoside (3) and 8-O-cafeoyl massenoside (4). The structures of these compounds were determined by FAB-MS, IR, 1D and 2D-NMR spectroscopy and by comparing with the published data of the closely related compounds. The antioxidant potential of the isolated iridoids (1-4) was evaluated relative to conventionally used standards and these molecules exhibited good antioxidant potential. Moreover, their inhibitory potential was also screened against three enzymes, namely acetyl cholinesterase, butyrylcholinesterase and lipoxygenase. These iridoid glucosides were found to be inactive against acetyl and butyrylcholinesterases but active against lipoxygenase.
authors.affiliation: Department of Chemistry, Government College University, Lahore-54000, Pakistan.
authors.forename: Tayyaba
authors.initials: T
authors.lastname: Shahzadi
authors.forename: Muhammad Athar
authors.initials: MA
authors.lastname: Abbasi
authors.forename: Aziz
authors.initials: A
authors.lastname: Ur-Rehman
authors.forename: Tauheeda
authors.initials: T
authors.lastname: Riaz
authors.forename: Khalid Mohammed
authors.initials: KM
authors.lastname: Khan
authors.forename: Muhammad
authors.initials: M
authors.lastname: Ashraf
authors.forename: Iftikhar
authors.initials: I
authors.lastname: Afzal
authors.forename: Muhammad Nadeem
authors.initials: MN
authors.lastname: Akhtar
authors.forename: Muhammad
authors.initials: M
authors.lastname: Ajaib
mesh_terms: D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology; D057888:Iridoid Glucosides / Q000737:chemistry* / Q000494:pharmacology; D019686:Lamiaceae / Q000737:chemistry*; D008084:Lipoxygenase / Q000378:metabolism; D016859:Lipoxygenase Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
chemical_list: D000975:Antioxidants; D057888:Iridoid Glucosides; D016859:Lipoxygenase Inhibitors; D008084:Lipoxygenase