title: Magnetic micelles as a potential platform for dual targeted drug delivery in cancer therapy.
abstract: The magnetic nanomicelles as a potential platform for dual targeted (folate-mediated and magnetic-guided) drug delivery were developed to enhance the efficiency and veracity of drug delivering to tumor site. The magnetic nanocarriers were synthesized based on superparamagnetic iron oxide nanoparticles (SPIONs), biocompatible Pluronic F127 and poly(dl-lactic acid) (F127-PLA) copolymer chemically conjugated with tumor-targeting ligand-folic acid (FA) via a facile chemical conjugation method. Doxorubicin hydrochloride (DOX·HCl) was selected as a model anticancer drug to investigate the in vitro drug release and antiproliferative effect of tumor cells in vitro and in vivo in the presence or absence of an external magnetic filed (MF) with strength of 0.1T. The Alamar blue assay exhibited that these magnetic nanomicelles possessed remarkable cell-specific targeting in vitro. Additionally this smart system enabling folate receptor-mediated uptake into tumor cells, showed strong responsiveness to MF. The primary in vivo tumor model study, which was carried out in VX2 tumor-bearing male New Zealand white rabbits, demonstrated that the nanomicelles could be guided into tumor site more efficiently by application of MF, and further represented significant therapeutic efficiency to solid tumor.
authors.affiliation: School of Materials Science and Engineering, Key Laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu 610031, PR China.
authors.forename: Chi
authors.initials: C
authors.lastname: Huang
authors.forename: Zhaomin
authors.initials: Z
authors.lastname: Tang
authors.forename: Yangbo
authors.initials: Y
authors.lastname: Zhou
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Zhou
authors.forename: Yong
authors.initials: Y
authors.lastname: Jin
authors.forename: Dan
authors.initials: D
authors.lastname: Li
authors.forename: Ying
authors.initials: Y
authors.lastname: Yang
authors.forename: Shaobing
authors.initials: S
authors.lastname: Zhou
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects; D004317:Doxorubicin / Q000008:administration & dosage* / Q000494:pharmacology; D016503:Drug Delivery Systems; D005290:Ferric Compounds / Q000737:chemistry*; D058973:Folate Receptors, GPI-Anchored / Q000378:metabolism; D005492:Folic Acid / Q000737:chemistry*; D056945:Hep G2 Cells; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry; D060526:Magnetic Fields; D008280:Magnetics; D008297:Male; D051379:Mice; D008823:Micelles; D041681:NIH 3T3 Cells; D053758:Nanoparticles; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D010078:Oxazines / Q000737:chemistry; D010316:Particle Size; D020442:Poloxamer / Q000737:chemistry; D011091:Polyesters; D011108:Polymers / Q000737:chemistry; D011817:Rabbits; D014966:Xanthenes / Q000737:chemistry
chemical_list: D000903:Antibiotics, Antineoplastic; D005290:Ferric Compounds; D058973:Folate Receptors, GPI-Anchored; D008823:Micelles; D010078:Oxazines; D011091:Polyesters; D011108:Polymers; D014966:Xanthenes; D020442:Poloxamer; C005843:resazurin; C000499:ferric oxide; D019344:Lactic Acid; C033616:poly(lactide); D004317:Doxorubicin; D005492:Folic Acid