title: Swine atrophic rhinitis caused by pasteurella multocida toxin and bordetella dermonecrotic toxin.
abstract: Atrophic rhinitis is a widespread and economically important swine disease caused by Pasteurella multocida and Bordetella bronchiseptica. The disease is characterized by atrophy of the nasal turbinate bones, which results in a shortened and deformed snout in severe cases. P. multocida toxin and B. bronchiseptica dermonecrotic toxin have been considered to independently or cooperatively disturb the osteogenesis of the turbinate bone by inhibiting osteoblastic differentiation and/or stimulating bone resorption by osteoclasts. Recently, the intracellular targets and molecular actions of both toxins have been clarified, enabling speculation on the intracellular signals leading to the inhibition of osteogenesis.
authors.affiliation: Department of Molecular Bacteriology, Research Institute for Microbial Diseases, Osaka University, Yamada-oka 3-1, Suita, Osaka 565-0871, Japan. horiguti@biken.osaka-u.ac.jp
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Horiguchi
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D001427:Bacterial Toxins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D001862:Bone Resorption / Q000382:microbiology / Q000473:pathology; D001885:Bordetella Infections / Q000235:genetics / Q000378:metabolism* / Q000382:microbiology; D016950:Bordetella bronchiseptica / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity; D060085:Coinfection; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D016979:Pasteurella multocida / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity; D012222:Rhinitis, Atrophic / Q000235:genetics / Q000378:metabolism* / Q000382:microbiology; D015398:Signal Transduction; D013552:Swine; D013553:Swine Diseases / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology; D011503:Transglutaminases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D014420:Turbinates / Q000382:microbiology / Q000473:pathology; D010566:Virulence Factors, Bordetella / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
chemical_list: D001426:Bacterial Proteins; D001427:Bacterial Toxins; C062258:Pasteurella multocida toxin; D010566:Virulence Factors, Bordetella; C060969:dermonecrotic toxin, Bordetella; D011503:Transglutaminases; D020962:Heterotrimeric GTP-Binding Proteins