title: [Structural and functional parameters of the vascular bed in premenopausal hypertensive women].
abstract: OBJECTIVE
  To study structural and functional characteristics of the vascular bed in premenopausal women with arterial hypertension (AH) and changes in hormone levels.
  
  
  METHODS
  Duplex scanning of the common carotid arteries (CCA) was made in 180 females with premenopausal hypertension.
  
  
  RESULTS
  Hypertensive women in premenopause with sexual hormones unbalance exhibited a wide CCA lumen in the absence of hemodynamically significant stenosis. This evidences for marked structural and functional changes of the vascular wall in the form of arteriosclerosis. Such patients' postocclusive reactive hyperemia test demonstrates a significant decline of vasomotor endothelial function, 43% cases show an inertial type of the vasomotor reaction reflecting an important role of hormonal unbalance in AH progression primarily due to increased stiffness of the vascular wall and endothelial dysfunction.
  
  
  CONCLUSIONS
  Premenopausal women with hypertension and hormonal unbalance should be examined with consideration of the fact that impaired status of sexual hormones is an independent factor of risk of AH progression and they should be referred to a separate group of follow-up. Their treatment policy must be formed by both cardiologist and gynecological endocrinologist.
authors.forename: M M
authors.initials: MM
authors.lastname: Khabibulina
mesh_terms: D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D017536:Carotid Artery, Common / Q000473:pathology* / Q000503:physiopathology; D004548:Elasticity; D004730:Endothelium, Vascular / Q000473:pathology / Q000503:physiopathology; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000473:pathology* / Q000503:physiopathology; D008875:Middle Aged; D017697:Premenopause / Q000097:blood; D017539:Tunica Intima / Q000473:pathology / Q000503:physiopathology; D018616:Ultrasonography, Doppler, Duplex
chemical_list: D004958:Estradiol; D005640:Follicle Stimulating Hormone