title: Expression of soluble HLA-G in multiple myeloma patients and patients with renal failure.
abstract: Human lymphocyte antigen-G (HLA-G) is an immunosuppressive molecule that induces functional silencing of immune component cells and can be responsible for immunosuppression in patients with multiple myeloma (MM). Immune dysfunction is an important feature of MM and leads to infections as well as may promote disease progression. Ninety-five patients were included in this study. In MM, the sHLA-G levels were increased when compared to healthy volunteers and the levels of sHLA-G correlated with concentration of creatinine. Interestingly, we detected high levels of sHLA-G in patients with renal insufficiency without any malignant disease but levels were lower than in MM.
authors.affiliation: Department of Experimental Hematooncology, Medical University of Lublin, Lublin, Poland.
authors.forename: Paulina
authors.initials: P
authors.lastname: Wlasiuk
authors.forename: Anna
authors.initials: A
authors.lastname: Stec
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Piechnik
authors.forename: Wioletta
authors.initials: W
authors.lastname: Kaminska
authors.forename: Anna
authors.initials: A
authors.lastname: Dmoszynska
authors.forename: Andrzej
authors.initials: A
authors.lastname: Ksiazek
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Giannopoulos
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D015331:Cohort Studies; D003404:Creatinine / Q000032:analysis / Q000097:blood; D005260:Female; D059951:HLA-G Antigens / Q000097:blood* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood* / Q000276:immunology / Q000378:metabolism; D009994:Osmolar Concentration; D051437:Renal Insufficiency / Q000097:blood* / Q000276:immunology / Q000378:metabolism; D012995:Solubility; D055815:Young Adult
chemical_list: D059951:HLA-G Antigens; D003404:Creatinine