title: Nonischemic chest pain following successful percutaneous coronary intervention at a regional referral centre in southern Ontario.
abstract: BACKGROUND
  The purpose of this study was to identify factors that predispose individuals to nonischemic chest pain following successful percutaneous coronary intervention (PCI).
  
  
  METHODS
  We prospectively followed, for 6 months, a cohort of 110 patients who underwent PCI. We determined baseline factors associated with post PCI pain via nonlinear mixed model regression; a binomial distribution with logit link was used.
  
  
  RESULTS
  The mean age of participants (n = 110) was 64 (SD ± 11.19), 69% were male. The majority had 1 coronary vessel dilated (88%) and a single stent placement (67%). During follow-up, chest pain was prevalent in 54% (95% confidence interval [CI], 44.8-63.7) and 45% (95% CI, 36.0-54.8) of patients, at 3 and 6 months respectively. Less than half of those with chest pain were evaluated for ischemia. Of those evaluated, tests were negative for the majority; 74% and 61% at 3 and 6 months respectively. Higher baseline depression (odds ratio 1.50; 95% CI, 1.13-1.99) scores (Hospital Anxiety Depression Scale) were significantly associated with nonischemic chest pain during follow-up.
  
  
  CONCLUSIONS
  Higher baseline depression scores were found to be significant risk factors for chest pain of nonischemic origin following successful PCI. A larger study is needed to confirm the predictive value of this and other factors that may contribute to this elusive pain problem. Further research is also required to develop pain management strategies for patients whose chest pain persists in the absence of discernible ischemic causes.
authors.affiliation: University of Toronto, Toronto, Ontario, Canada. michael.mcgillion@utoronto.ca
authors.forename: Michael
authors.initials: M
authors.lastname: McGillion
authors.forename: Heather M
authors.initials: HM
authors.lastname: Arthur
authors.forename: Madhu
authors.initials: M
authors.lastname: Natarajan
authors.forename: Allison
authors.initials: A
authors.lastname: Cook
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Gunn
authors.forename: Judy
authors.initials: J
authors.lastname: Watt-Watson
authors.forename: Kevin
authors.initials: K
authors.lastname: Thorpe
authors.forename: Tammy
authors.initials: T
authors.lastname: Cosman
mesh_terms: D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects*; D002637:Chest Pain / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology; D016001:Confidence Intervals; D003324:Coronary Artery Disease / Q000473:pathology / Q000628:therapy*; D003331:Coronary Vessels / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000150:complications / Q000453:epidemiology / Q000503:physiopathology; D009864:Ontario / Q000453:epidemiology; D010147:Pain Measurement / Q000379:methods*; D011183:Postoperative Complications / Q000453:epidemiology / Q000209:etiology; D015995:Prevalence; D011446:Prospective Studies; D012017:Referral and Consultation / Q000706:statistics & numerical data; D012307:Risk Factors; D012720:Severity of Illness Index; D015607:Stents