title: A moderate red wine intake improves blood lipid parameters and erythrocytes membrane fluidity in post myocardial infarct patients.
abstract: While the cardioprotective effect of moderate and regular wine consumption in primary prevention has been well documented, the goal of the present investigation was to explore the effect of wine intake on blood parameters (lipid, anti-oxidant capacity, and erythrocyte membrane potential and fluidity) in post myocardial infarct patients to evaluate perspectives in secondary prevention. A clinical intervention trial has been undertaken on a group of selected post myocardial infarct patients who gave written informed consent for participation in this study prior to enrolment. This two-week study has been conducted on hospitalized patients during a cardiac readaptation period. During this period, patients were submitted to a "Western prudent" diet (inspired by the Mediterranean diet) and two groups have been compared on a drawn basis: patients receiving red wine (250 mL daily) to patients receiving water. Physical, clinical, and blood parameters were evaluated on Days 1 and 14. The data show a positive effect of low wine consumption on blood parameters (decrease in total cholesterol and LDL; increase in erythrocyte membrane fluidity and antioxidant status). The results show that a moderate consumption of red wine even for a short period associated with a "Western prudent" diet improves various blood parameters in lipid and anti-oxidative status in patients with previous coronary ischemic accidents.
authors.affiliation: INSERM UMR 866-LBMN, Université de Bourgogne, Dijon, France.
authors.forename: Jean-Pierre
authors.initials: JP
authors.lastname: Rifler
authors.forename: Fanny
authors.initials: F
authors.lastname: Lorcerie
authors.forename: Philippe
authors.initials: P
authors.lastname: Durand
authors.forename: Dominique
authors.initials: D
authors.lastname: Delmas
authors.forename: Kévin
authors.initials: K
authors.lastname: Ragot
authors.forename: Emeric
authors.initials: E
authors.lastname: Limagne
authors.forename: Frédéric
authors.initials: F
authors.lastname: Mazué
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Riedinger
authors.forename: Philippe
authors.initials: P
authors.lastname: d'Athis
authors.forename: Bernard
authors.initials: B
authors.lastname: Hudelot
authors.forename: Michel
authors.initials: M
authors.lastname: Prost
authors.forename: Gérard
authors.initials: G
authors.lastname: Lizard
authors.forename: Norbert
authors.initials: N
authors.lastname: Latruffe
mesh_terms: D000975:Antioxidants / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D016207:Cytokines / Q000097:blood; D004032:Diet; D004910:Erythrocyte Membrane / Q000187:drug effects*; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008560:Membrane Fluidity / Q000187:drug effects; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000178:diet therapy* / Q000534:rehabilitation; D012709:Serum Albumin / Q000378:metabolism; D014280:Triglycerides / Q000097:blood; D014920:Wine
chemical_list: D000975:Antioxidants; D016207:Cytokines; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D012709:Serum Albumin; D014280:Triglycerides; D002784:Cholesterol