title: The role of canonical WNT signaling pathway in oral carcinogenesis: a comprehensive review.
abstract: Oral cancer is a common neoplasm worldwide. The incidence and mortality have also increased in recent decades. It is characterized by poor prognosis and a low survival rate despite sophisticated surgical and radiotherapeutic modalities. The WNTs comprise a large family of highly conserved growth factors associated with a number of functions. In this review, we focus largely on the canonical pathway, revealing the recent findings, in oral cancer research, thereby raising our understanding of the mechanisms of this crucial signaling in several cellular activities.
authors.affiliation: Department of Pathology, Federal University of São Paulo, UNIFESP, SP, Brazil.
authors.forename: Juliana
authors.initials: J
authors.lastname: Noguti
authors.forename: Carolina Foot Gomes
authors.initials: CF
authors.lastname: DE Moura
authors.forename: Thais Ayako
authors.initials: TA
authors.lastname: Hossaka
authors.forename: Marcello
authors.initials: M
authors.lastname: Franco
authors.forename: Celina Tijuko Fujiyama
authors.initials: CT
authors.lastname: Oshima
authors.forename: Rogerio Aparecido
authors.initials: RA
authors.lastname: Dedivitis
authors.forename: Daniel Araki
authors.initials: DA
authors.lastname: Ribeiro
mesh_terms: D017209:Apoptosis; D002471:Cell Transformation, Neoplastic; D006801:Humans; D009062:Mouth Neoplasms / Q000378:metabolism* / Q000473:pathology; D015398:Signal Transduction; D051153:Wnt Proteins / Q000378:metabolism*
chemical_list: D051153:Wnt Proteins