title: Hydroxyapatite-alginate nanocomposite as drug delivery matrix for sustained release of ciprofloxacin.
abstract: Hydroxyapatite is a bioceramic which has a wide range of medical application for bone diseases. To enhance its usage, we have prepared ciprofloxacin loaded nano hydroxyapatite (HA) composite with a natural polymer, alginate, using wet chemical method at low temperature. The prepared composites were analyzed by various physicochemical methods. The results show that the nano HA crystallites are well intact with the alginate macromolecules. For the composite system FT-IR and micro Raman results are reported in this paper. Studies on the drug loading and drug release have been done. The drug is pre-adsorbed onto the ceramic particle before the formation of composite. The thermal behavior of composite has been studied using thermo gravimetric analysis (TGA). This work, reports that the nanocomposite prepared under optimum condition could prolong the release of ciprofloxacin compared with the ciprofloxacin loaded hydroxyapatite.
authors.affiliation: Crystal Growth Centre, Anna University, Chennai-600025, Tamilnadu, India.
authors.forename: G Devanand
authors.initials: GD
authors.lastname: Venkatasubbu
authors.forename: S
authors.initials: S
authors.lastname: Ramasamy
authors.forename: V
authors.initials: V
authors.lastname: Ramakrishnan
authors.forename: J
authors.initials: J
authors.lastname: Kumar
mesh_terms: D000464:Alginates / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D002939:Ciprofloxacin / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D017886:Durapatite / Q000737:chemistry*; D020723:Glucuronic Acid / Q000737:chemistry; D006603:Hexuronic Acids / Q000737:chemistry; D053761:Nanocomposites / Q000737:chemistry*
chemical_list: D000464:Alginates; D000890:Anti-Infective Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D006603:Hexuronic Acids; D002939:Ciprofloxacin; D020723:Glucuronic Acid; D017886:Durapatite