title: Selective deuteration of (hetero)aromatic compounds via deutero-decarboxylation of carboxylic acids.
abstract: A practical, mild and highly selective protocol for the monodeuteration of a variety of arenes and heteroarenes is presented. Catalytic amounts of Ag(I) salts in DMSO/D(2)O are shown to facilitate the deutero-decarboxylation of ortho-substituted benzoic and heteroaromatic α-carboxylic acids in high yields with excellent levels of deuterium incorporation.
authors.affiliation: School of Biological and Chemical Sciences, Queen Mary University of London, Joseph Priestley Building, Mile End Road, E1 4NS, London, UK.
authors.forename: Rachel
authors.initials: R
authors.lastname: Grainger
authors.forename: Arif
authors.initials: A
authors.lastname: Nikmal
authors.forename: Josep
authors.initials: J
authors.lastname: Cornella
authors.forename: Igor
authors.initials: I
authors.lastname: Larrosa
mesh_terms: D002264:Carboxylic Acids / Q000737:chemistry*; D003653:Decarboxylation; D003903:Deuterium / Q000737:chemistry*; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*
chemical_list: D002264:Carboxylic Acids; D006841:Hydrocarbons, Aromatic; D003903:Deuterium