title: New verticillane diterpenoids from Cespitularia taeniata.
abstract: Chemical investigation of Cespitularia taeniata has led to the isolation of three new verticillanes, cespitulins E-G (1-3, resp.). The structures of these compounds were elucidated by spectroscopic analysis, especially HR-MS and 2D-NMR techniques. Compound 1 possesses a rare norverticillane skeleton with two adjacent OH groups at C(5) and C(6), while the seco-compound 2 with an aldehyde group at C(9) results from an unusual bond cleavage between C(9) and C(10). Pharmacological studies revealed that compound 3 exhibited significant activities on superoxide-anion generation and elastase release by human neutrophils in response to FMLP/CB. A plausible biogenetic pathway for compound 2 is also discussed.
authors.affiliation: School of Pharmacy, College of Medicine, National Taiwan University, Jen-Ai Rd. Sec. 1, Taipei 100, Taiwan.
authors.forename: Jiun-Yang
authors.initials: JY
authors.lastname: Chang
authors.forename: Ahmed Eid
authors.initials: AE
authors.lastname: Fazary
authors.forename: Yu-Chi
authors.initials: YC
authors.lastname: Lin
authors.forename: Tsong-Long
authors.initials: TL
authors.lastname: Hwang
authors.forename: Ya-Ching
authors.initials: YC
authors.lastname: Shen
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008968:Molecular Conformation; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D010196:Pancreatic Elastase / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism
chemical_list: D004224:Diterpenes; C573271:cespitulin E; C573272:cespitulin F; C573273:cespitulin G; C547635:verticillane; D013481:Superoxides; D010196:Pancreatic Elastase