title: Pattern recognition receptors in immune disorders affecting the skin.
abstract: Pattern recognition receptors (PRRs) evolved to protect organisms against pathogens, but excessive signaling can induce immune responses that are harmful to the host. Putative PRR dysfunction is associated with numerous immune disorders that affect the skin, such as systemic lupus erythematosus, cryopyrin-associated periodic syndrome, and primary inflammatory skin diseases including psoriasis and atopic dermatitis. As yet, the evidence is often confined to genetic association studies without additional proof of a causal relationship. However, insight into the role of PRRs in the pathophysiology of some disorders has already resulted in new therapeutic approaches based on immunomodulation of PRRs.
authors.affiliation: Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. h.dekoning@derma.umcn.nl
authors.forename: Heleen D
authors.initials: HD
authors.lastname: de Koning
authors.forename: Anna
authors.initials: A
authors.lastname: Simon
authors.forename: Patrick L J M
authors.initials: PL
authors.lastname: Zeeuwen
authors.forename: Joost
authors.initials: J
authors.lastname: Schalkwijk
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000235:genetics / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics; D051379:Mice; D018345:Mice, Knockout; D058990:Molecular Targeted Therapy / Q000639:trends; D051192:Receptors, Pattern Recognition / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D015398:Signal Transduction / Q000235:genetics / Q000276:immunology; D012867:Skin / Q000187:drug effects / Q000276:immunology*; D012871:Skin Diseases / Q000188:drug therapy / Q000235:genetics / Q000276:immunology*; D012878:Skin Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000276:immunology*
chemical_list: D051192:Receptors, Pattern Recognition