title: Detection of temporal lobe seizures and identification of lateralisation from audified EEG.
abstract: OBJECTIVE
  To investigate the accuracy of human listeners in identifying epileptic seizures and seizure lateralisation from audified EEG signals.
  
  
  METHODS
  EEG data from 17 temporal lobe epilepsy patients (9 male, 8 female; aged 23-55) was converted to audio format by 60× time compression. Using a subset of 19% of the data, five auditory participants (2 female, 3 male; aged 23-58) were trained to identify seizures and their lateralisation by listening to audified EEG signals from difference electrodes P3-T5 and P4-T6. Following training, seizure detection performance of the auditory participants was tested using the remaining data.
  
  
  RESULTS
  Allowing a 5s auditory time margin for successful detection, the mean sensitivity of the five auditory participants was 89.6% (SD 8.3%) with a false detection rate of only 0.0068/h (SD 0.0077/h). The mean accuracy of seizure lateralisation identification was 77.6% (SD 7.1%).
  
  
  CONCLUSIONS
  With a limited amount of training, humans can detect seizures and seizure lateralisation from audified EEG signals of electrodes P3-T5 and P4-T6 with accuracy comparable to visual assessment of full EEG traces (21 electrodes) by an expert encephalographer.
  
  
  CONCLUSIONS
  A more efficient and accurate clinical tool for assessing EEG data based on audification may be developed, which will improve diagnosis and treatment of epilepsy.
authors.affiliation: Comprehensive Epilepsy Service, Royal Prince Alfred Hospital, Sydney, NSW 2050, Australia. heba.khamis@sydney.edu.au
authors.forename: H
authors.initials: H
authors.lastname: Khamis
authors.forename: A
authors.initials: A
authors.lastname: Mohamed
authors.forename: S
authors.initials: S
authors.lastname: Simpson
authors.forename: A
authors.initials: A
authors.lastname: McEwan
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D058256:Brain Waves / Q000502:physiology*; D004569:Electroencephalography / Q000379:methods*; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis* / Q000503:physiopathology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D017603:Signal Detection, Psychological; D013997:Time Factors; D055815:Young Adult