title: The relationship between atrophy of the medial temporal area and daily activities in older adults with mild cognitive impairment.
abstract: OBJECTIVE
  Many studies have suggested that social network, leisure activity, and physical activity can have protective effects against dementia and Alzheimer's disease. However, previous studies have not examined the relationship between daily activities and brain atrophy in older adults. This study aimed to explore what kind of daily activities were associated with atrophy of the medial temporal area including the entorhinal cortex (MTA-ERC) in older adults.
  
  
  METHODS
  In total, 122 older adults (aged 65 and over) with subjective memory complaints or a Clinical Dementia Rating of 0.5 underwent magnetic resonance imaging, and MTA-ERC atrophy was assessed by the voxel- based morphometry method. Based on magnetic resonance imaging data, the subjects were divided into atrophy and non-atrophy groups. Daily activities were assessed using a 20-item questionnaire (e.g., instrumental activities of daily living, social activities), and we compared activity participation between the groups.
  
  
  RESULTS
  The atrophy group (n=37) showed significantly lower participation in 4 out of 20 activity items (cleaning, intellectual activity, culture lessons, and using a personal computer) than the non-atrophy group (n=85). Summed scores of these 4 items (range from 0 to 4) were significantly associated with MTA-ERC atrophy even after adjustment for age, sex, education status, and Mini-Mental State Examination score.
  
  
  CONCLUSIONS
  In conclusion, MTAERC atrophy was associated with cognitive activities or household-related activities requiring planning.
authors.affiliation: Section for Health Promotion, Department of Health and Medical Care, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, Obu, Aichi, Japan. yoshida@ncgg.go.jp
authors.forename: Daisuke
authors.initials: D
authors.lastname: Yoshida
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Shimada
authors.forename: Hyuma
authors.initials: H
authors.lastname: Makizako
authors.forename: Takehiko
authors.initials: T
authors.lastname: Doi
authors.forename: Kengo
authors.initials: K
authors.lastname: Ito
authors.forename: Takashi
authors.initials: T
authors.lastname: Kato
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shimokata
authors.forename: Yukihiko
authors.initials: Y
authors.lastname: Washimi
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Endo
authors.forename: Takao
authors.initials: T
authors.lastname: Suzuki
mesh_terms: D000203:Activities of Daily Living; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D000465:Algorithms; D001284:Atrophy / Q000503:physiopathology*; D001931:Brain Mapping / Q000379:methods; D003071:Cognition; D060825:Cognitive Dysfunction / Q000503:physiopathology*; D005260:Female; D006801:Humans; D016013:Likelihood Functions; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D011336:Probability; D015203:Reproducibility of Results; D011795:Surveys and Questionnaires; D013702:Temporal Lobe / Q000503:physiopathology*