title: Genetic Risk and Outcome of Psychosis (GROUP), a multi-site longitudinal cohort study focused on gene-environment interaction: objectives, sample characteristics, recruitment and assessment methods.
abstract: OBJECTIVE
  A longitudinal focus on gene-environment vulnerability and resilience in both patients, their unaffected family members and non-related controls offers the opportunity to elucidate etiological and pathogenetic factors influencing the onset and course of psychotic disorders. The current paper delineates the objectives, sample characteristics, recruitment and assessment procedures of the Genetic Risk and Outcome of Psychoses (GROUP) study.
  
  
  METHODS
  A naturalistic longitudinal cohort study with assessments at baseline, after three and six years of follow-up. The study is conducted by a consortium of four university psychiatric centres, with their affiliated mental health care institutions in the Netherlands covering more than 7.5 million inhabitants. Extensive assessment of genetic factors, environmental factors, (endo)phenotypes, and outcome.
  
  
  RESULTS
  At baseline, 1120 patients, 1057 siblings, 919 parents and 590 healthy controls were included.
  
  
  CONCLUSIONS
  The GROUP study will contribute to insight in risk and protective factors in the aetiology of non-affective psychotic disorders, and in the variation in their course and outcome.
authors.affiliation: Academic Medical Center, Department of Psychiatry, University of Amsterdam, The Netherlands.
authors.forename: Nikie
authors.initials: N
authors.lastname: Korver
authors.forename: Piotr J
authors.initials: PJ
authors.lastname: Quee
authors.forename: Heleen B M
authors.initials: HB
authors.lastname: Boos
authors.forename: Claudia J P
authors.initials: CJ
authors.lastname: Simons
authors.forename: Lieuwe
authors.initials: L
authors.lastname: de Haan
mesh_terms: D000293:Adolescent; D000328:Adult; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D059647:Gene-Environment Interaction; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D011618:Psychotic Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D012107:Research Design / Q000592:standards*; D012306:Risk; D012559:Schizophrenia / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics; D013997:Time Factors; D055815:Young Adult