title: Racial disparity in maternal and fetal-cord bisphenol A concentrations.
abstract: OBJECTIVE
  To determine if racial disparities exist in maternal and fetal cord serum concentrations of bisphenol A (BPA).
  
  
  METHODS
  A nested cross-sectional study was performed from a cohort of 600 term nulliparas. In 27 patients (8 Caucasian, 8 African-American and 11 Hispanic), term pre-labor maternal serum and corresponding fetal-cord serum were analyzed for BPA. result: African-Americans had the highest maternal serum concentrations, 10-fold higher than Caucasians (30.13 vs 3.14 ng ml(-1); P=0.038). Hispanics had intermediate concentrations with a trend towards higher concentrations compared with Caucasians (24.46 vs 3.14 ng ml(-1); P=0.051). Overall concentrations were 10-fold higher in maternal samples than fetal samples (14.1 vs 1.3 ng ml(-1); P=0.001). Hispanics had higher fetal concentrations than non-Hispanics (2.05 vs 0.35 ng ml(-1); P=0.025).
  
  
  CONCLUSIONS
  We found significant racial/ethnic differences in maternal/fetal BPA concentrations. Further study is needed to determine if these differences reflect disparities in exposure, metabolism or placental transfer.
authors.affiliation: Department of Obstetrics and Gynecology, Division of Maternal-Fetal Medicine, Medical University of South Carolina, Charleston, SC, USA. unal@musc.edu
authors.forename: E R
authors.initials: ER
authors.lastname: Unal
authors.forename: T
authors.initials: T
authors.lastname: Lynn
authors.forename: J
authors.initials: J
authors.lastname: Neidich
authors.forename: D
authors.initials: D
authors.lastname: Salazar
authors.forename: L
authors.initials: L
authors.lastname: Goetzl
authors.forename: J E
authors.initials: JE
authors.lastname: Baatz
authors.forename: T C
authors.initials: TC
authors.lastname: Hulsey
authors.forename: R
authors.initials: R
authors.lastname: Van Dolah
authors.forename: L J
authors.initials: LJ
authors.lastname: Guillette
authors.forename: R
authors.initials: R
authors.lastname: Newman
mesh_terms: D000293:Adolescent; D000328:Adult; D001741:Black or African American; D001559:Benzhydryl Compounds; D003430:Cross-Sectional Studies; D004651:Employment; D004785:Environmental Pollutants / Q000032:analysis; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D006630:Hispanic or Latino; D006801:Humans; D008297:Male; D008431:Maternal-Fetal Exchange; D009035:Mothers; D010636:Phenols; D011247:Pregnancy / Q000097:blood; D053719:Tandem Mass Spectrometry / Q000379:methods; D044465:White People; D055815:Young Adult; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D004785:Environmental Pollutants; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds