title: Copper-catalyzed di- and trifluoromethylation of α,β-unsaturated carboxylic acids: a protocol for vinylic fluoroalkylations.
abstract: Dual action: the Lewis acid CuF(2) ⋅2 H(2)O efficiently catalyzes the reaction between electrophilic fluoroalkylating agents and α,β-unsaturated carboxylic acids by dually activating both reactants, thus affording di- and trifluoromethyl alkenes in high yields with excellent E/Z selectivity.
authors.affiliation: Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, China.
authors.forename: Zhengbiao
authors.initials: Z
authors.lastname: He
authors.forename: Tao
authors.initials: T
authors.lastname: Luo
authors.forename: Mingyou
authors.initials: M
authors.lastname: Hu
authors.forename: Yanjing
authors.initials: Y
authors.lastname: Cao
authors.forename: Jinbo
authors.initials: J
authors.lastname: Hu
mesh_terms: D000475:Alkenes; D000478:Alkylation; D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D005461:Fluorine / Q000737:chemistry*; D014753:Vinyl Compounds / Q000737:chemistry*
chemical_list: D000475:Alkenes; D002264:Carboxylic Acids; D014753:Vinyl Compounds; D005461:Fluorine; D003300:Copper