title: Acute cardiopulmonary failure from sleep-disordered breathing.
abstract: Sleep-disordered breathing (SDB) comprises a diverse set of disorders marked by abnormal respiration during sleep. Clinicians should realize that SDB may present as acute cardiopulmonary failure in susceptible patients. In this review, we discuss three clinical phenotypes of acute cardiopulmonary failure from SDB: acute ventilatory failure, acute congestive heart failure, and sudden death. We review the pathophysiologic mechanisms and recommend general principles for management. Timely recognition of, and therapy for, SDB in the setting of acute cardiopulmonary failure may improve short- and long-term outcomes.
authors.affiliation: Section of Pulmonary, Allergy, Critical Care, and Sleep Medicine, University of Arizona College of Medicine, Tucson AZ.
authors.forename: Gordon E
authors.initials: GE
authors.lastname: Carr
authors.affiliation: Section of Pulmonary and Critical Care, Sleep Disorders Center, University of Chicago Pritzker School of Medicine, Chicago, IL.
authors.forename: Babak
authors.initials: B
authors.lastname: Mokhlesi
authors.affiliation: Division of Pulmonary, Critical Care, and Occupational Medicine, University of Iowa Carver College of Medicine, Iowa City, IA. Electronic address: brian-gehlbach@uiowa.edu.
authors.forename: Brian K
authors.initials: BK
authors.lastname: Gehlbach
mesh_terms: D000208:Acute Disease; D016757:Death, Sudden, Cardiac / Q000209:etiology*; D006333:Heart Failure / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D010641:Phenotype; D011379:Prognosis; D012131:Respiratory Insufficiency / Q000209:etiology* / Q000503:physiopathology; D012891:Sleep Apnea Syndromes / Q000150:complications* / Q000628:therapy; D020181:Sleep Apnea, Obstructive / Q000150:complications / Q000628:therapy