title: Sliding clamps: an open and shut case?
abstract: Molecular events in the clamp-loading reaction pathway of DNA replication are revealed by new crystal structures of bacteriophage T4 clamp loader-clamp-DNA complexes that capture two distinct conformations with the clamp open and closed.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Florida, Gainesville, FL 32610-0245, USA. lbloom@ufl.edu
authors.forename: Linda B
authors.initials: LB
authors.lastname: Bloom
authors.forename: Jaclyn N
authors.initials: JN
authors.lastname: Hayner
mesh_terms: D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics; D017122:Bacteriophage T4 / Q000235:genetics; D004261:DNA Replication; D004279:DNA, Viral / Q000096:biosynthesis / Q000737:chemistry; D004259:DNA-Directed DNA Polymerase / Q000737:chemistry* / Q000378:metabolism*; D004926:Escherichia coli / Q000235:genetics; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D011487:Protein Conformation; D012441:Saccharomyces cerevisiae / Q000235:genetics; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry / Q000235:genetics; D014764:Viral Proteins / Q000737:chemistry / Q000235:genetics
chemical_list: D001426:Bacterial Proteins; D004279:DNA, Viral; D029701:Saccharomyces cerevisiae Proteins; D014764:Viral Proteins; D004259:DNA-Directed DNA Polymerase