title: Unifocal bone paracoccidioidomycosis, Brazil.
abstract: We report a 47 year-old man from the State of Mato Grosso do Sul, Brazil, with unifocal tibial paracoccidioidomycosis. A radiograph showed an osteolytic lesion on the tibial middle third diaphysis. The diagnosis was confirmed by histopathologic analysis, and treatment with sulfamethoxazole and trimethoprim was started. After three months, the patient showed significant clinical improvement. Ten months after treatment, the patient showed lesion bone healing. This case describes the rare occurrence of an osteolytic lesion caused by endemic Paracoccidioides brasiliensis in Latin America.
authors.affiliation: Faculty of Medicine, Universidade Federal de Mato Grosso do Sul, Campo Grande, Brazil. brunacorreac@hotmail.com
authors.forename: Bruna
authors.initials: B
authors.lastname: Correa-de-Castro
authors.forename: Mauricio A
authors.initials: MA
authors.lastname: Pompilio
authors.forename: Danilo N
authors.initials: DN
authors.lastname: Odashiro
authors.forename: Maçanori
authors.initials: M
authors.lastname: Odashiro
authors.forename: Adalberto
authors.initials: A
authors.lastname: Arão-Filho
authors.forename: Anamaria M M
authors.initials: AM
authors.lastname: Paniago
mesh_terms: D001850:Bone Diseases, Infectious / Q000382:microbiology*; D001938:Brazil / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010228:Paracoccidioides / Q000472:pathogenicity*; D010229:Paracoccidioidomycosis / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000453:epidemiology*; D011859:Radiography; D013977:Tibia / Q000382:microbiology* / Q000473:pathology; D016896:Treatment Outcome