title: P53, Bcl-2 and Ki67 immunoexpression in follicular solid ameloblastomas.
abstract: The study included a total of 17 ameloblastomas diagnosed in a range of 15 years. Clinical data processing was followed by histopathological and immunohistochemical analysis, following the expression of p53, Bcl-2 and Ki67 in the tumor epithelial compartments. Lesions predominated in the age range 20-40 years, to male gender, being located mainly in the mandible (88.2%). Typical follicular ameloblastoma was present in 70.6% of analyzed tumors. P53 and Bcl-2 immunoexpression was identified especially in the peripheral cells, the number of marked cells being over 50%, while the percentage of positive cells from the stellate reticulum was below 10%. The Ki67 positivity index was below 10% in both compartments. Squamous and granular cells reveal no stain for the investigated markers. Peripheral columnar cells are active compartment of ameloblastomas being involved in the processes of proliferation-apoptosis.
authors.affiliation: Department of Pathology, University of Medicine and Pharmacy of Craiova, Romania.
authors.forename: Alma
authors.initials: A
authors.lastname: Florescu
authors.forename: Cristiana
authors.initials: C
authors.lastname: Simionescu
authors.forename: Raluca
authors.initials: R
authors.lastname: Ciurea
authors.forename: Allma
authors.initials: A
authors.lastname: Pitru
mesh_terms: D000328:Adult; D000368:Aged; D000564:Ameloblastoma / Q000378:metabolism*; D017209:Apoptosis; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006651:Histocytochemistry / Q000379:methods; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D007573:Jaw Neoplasms / Q000378:metabolism*; D019394:Ki-67 Antigen / Q000096:biosynthesis*; D008297:Male; D008339:Mandibular Neoplasms / Q000378:metabolism; D008875:Middle Aged; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis*; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis*
chemical_list: D019394:Ki-67 Antigen; D019253:Proto-Oncogene Proteins c-bcl-2; C495901:TP53 protein, human; D016159:Tumor Suppressor Protein p53