title: Inter-individual variability in the pre-clinical drug cardiotoxic safety assessment--analysis of the age-cardiomyocytes electric capacitance dependence.
abstract: Electrical phenomena located within the plasma membrane of the mammalian cardiac cells are connected with the cells' main physiological functions--signals processing and contractility. They were extensively studied and described mathematically in so-called Hodgkin-Huxley paradigm. One of the physiological parameters, namely cell electric capacitance, has not been analyzed in-depth. The aim of the study was to validate the mechanistic model describing the capacitive properties of cells, based on a collected experimental dataset which describes the electric capacitance of human ventricular myocytes. The gathered data was further utilized for developing an empirical correlation between a healthy individual's age and cardiomyocyte electric capacitance.
authors.affiliation: Unit of Pharmacoepidemiology and Pharmacoeconomics, Faculty of Pharmacy, Medical College, Jagiellonian University, Medyczna 9 Str, 30-688, Cracow, Poland. spolak@cm-uj.krakow.pl
authors.forename: Sebastian
authors.initials: S
authors.lastname: Polak
authors.forename: Kamil
authors.initials: K
authors.lastname: Fijorek
mesh_terms: D000200:Action Potentials; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D002462:Cell Membrane / Q000187:drug effects* / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D003198:Computer Simulation; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D025802:Electric Capacitance; D005260:Female; D006331:Heart Diseases / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D015233:Models, Statistical; D032383:Myocytes, Cardiac / Q000187:drug effects* / Q000473:pathology; D015203:Reproducibility of Results; D018570:Risk Assessment; D013997:Time Factors; D018675:Toxicity Tests; D055815:Young Adult