title: Gold-catalyzed efficient synthesis of 2,4-disubstituted furans from aryloxy-enynes.
abstract: A series of (E)-1-aryloxy-1-en-3-ynes has been prepared by Sonogashira coupling of 2-bromo-3-aryloxypropenoates with terminal alkynes using Pd(PPh(3))(4) and CuI as the catalysts in Et(3)N. The resulting enynyl-aryl ethers are found to be highly applicable to the synthesis of 2,4-disubstituted furans with an ester group at C-4 position through an Au/Ag-catalyzed annulation reaction under extremely mild reaction conditions.
authors.affiliation: Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, 3663 North Zhongshan Road, Shanghai, 200062, People's Republic of China.
authors.forename: Ende
authors.initials: E
authors.lastname: Li
authors.forename: Wenjun
authors.initials: W
authors.lastname: Yao
authors.forename: Xin
authors.initials: X
authors.lastname: Xie
authors.forename: Chengyu
authors.initials: C
authors.lastname: Wang
authors.forename: Yushang
authors.initials: Y
authors.lastname: Shao
authors.forename: Yanzhong
authors.initials: Y
authors.lastname: Li
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry; D003500:Cyclization; D004987:Ethers / Q000737:chemistry; D005663:Furans / Q000138:chemical synthesis*; D006046:Gold / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry; D012834:Silver / Q000737:chemistry
chemical_list: D000480:Alkynes; D004987:Ethers; D005663:Furans; D012834:Silver; D010165:Palladium; D006046:Gold; D003300:Copper