title: Spectrum of purpura fulminans: report of three classical prototypes and review of management strategies.
abstract: Purpura fulminans is a rare syndrome of intravascular thrombosis and hemorrhagic infarction of the skin that is rapidly progressive and is accompanied by vascular collapse and disseminated intravascular coagulation. It usually occurs in children, but this syndrome has also been noted in adults. The three forms of this disease are classified by the triggering mechanisms. We describe three classical cases of purpura fulminans of the three classical prototypes treated at our center and their varied clinical outcomes. We also describe a case of acute infectious purpura fulminans secondary to systemic leptospirosis which to our best knowledge is the first reported case in world literature. The various treatment options for purpura fulminans have also been reviewed.
authors.affiliation: Department of Dermatology, Kempegowda Institute of Medical Sciences, Bangalore, India. drankurtalwar@yahoo.com
authors.forename: Ankur
authors.initials: A
authors.lastname: Talwar
authors.forename: Sharath
authors.initials: S
authors.lastname: Kumar
authors.forename: M G
authors.initials: MG
authors.lastname: Gopal
authors.forename: A S
authors.initials: AS
authors.lastname: Nandini
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002644:Chickenpox / Q000150:complications*; D002648:Child; D017809:Fatal Outcome; D005260:Female; D014645:Herpesvirus 3, Human; D006801:Humans; D007231:Infant, Newborn; D007922:Leptospirosis / Q000150:complications* / Q000188:drug therapy*; D008297:Male; D055665:Purpura Fulminans / Q000382:microbiology / Q000473:pathology / Q000821:virology; D012883:Skin Ulcer / Q000473:pathology / Q000601:surgery
chemical_list: D000900:Anti-Bacterial Agents