title: Curcumin bioavailability from enriched bread: the effect of microencapsulated ingredients.
abstract: Human bioavailability of curcumin from breads enriched with 1 g/portion of free curcumin (FCB), encapsulated curcumin (ECB), or encapsulated curcumin plus other polyphenols (ECBB) was evaluated. Parental and metabolized curcuminoids and phenolic acids were quantified by HPLC/MS/MS in blood, urine, and feces collected over 24 h. The concentrations of serum curcuminoids were always below 4 nmol/L and those of glucuronides 10-fold less. Encapsulation delayed and increased curcuminoid absorption as compared to the free ingredient. Serum and urinary concentrations of ferulic and vanillic acid were between 2- and 1000-fold higher than those of curcuminoids, with ECBB eliciting the highest amounts. Fecal curcuminoids were 6-fold more abundant after ECB than FCB, while phenolic acids after ECBB quadruplicated those after ECB. Curcuminoid encapsulation increased their bioavailability from enriched bread, probably preventing their biotransformation, with combined compounds slightly reducing this effect. Phenolic acids are the major metabolites of curcuminoids and may contribute to their biological properties.
authors.affiliation: Department of Food Science, University of Naples, Portici (NA), Italy. paola.vitaglione@unina.it
authors.forename: Paola
authors.initials: P
authors.lastname: Vitaglione
authors.forename: Roberta
authors.initials: R
authors.lastname: Barone Lumaga
authors.forename: Rosalia
authors.initials: R
authors.lastname: Ferracane
authors.forename: Irena
authors.initials: I
authors.lastname: Radetsky
authors.forename: Ilario
authors.initials: I
authors.lastname: Mennella
authors.forename: Rita
authors.initials: R
authors.lastname: Schettino
authors.forename: Saul
authors.initials: S
authors.lastname: Koder
authors.forename: Eyal
authors.initials: E
authors.lastname: Shimoni
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Fogliano
mesh_terms: D000328:Adult; D001682:Biological Availability; D001774:Blood Chemical Analysis; D001939:Bread / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D003474:Curcumin / Q000737:chemistry* / Q000378:metabolism*; D004063:Digestion; D004339:Drug Compounding; D005260:Female; D006801:Humans; D062385:Hydroxybenzoates / Q000097:blood / Q000378:metabolism / Q000652:urine; D008297:Male; D053719:Tandem Mass Spectrometry
chemical_list: D062385:Hydroxybenzoates; C017616:phenolic acid; D003474:Curcumin