title: Impact of family history of diabetes on β-cell function and insulin resistance among Chinese with normal glucose tolerance.
abstract: OBJECTIVE
  This study investigated the impact of family history of diabetes (FHD) on β-cell function among Chinese with normal glucose tolerance.
  
  
  METHODS
  A multistage, stratified, cluster random sampling method was used to select a provincially representative sample from Fujian Province. Eventually, a total of 1,183 subjects were entered into the analysis. Several indexes were used to assess the function of β cells, including homeostasis model assessment (HOMA) of insulin resistance (IR), HOMA of β cells, insulinogenic index (IGI), and disposition index.
  
  
  RESULTS
  Overweight, increased body mass index, higher low-density lipoprotein cholesterol, and higher total cholesterol (TC) were the dominant features of positive FHD (FHD(+)). The FHD(+) subjects had lower insulin sensitivity (P<0.05). FHD(+) subjects showed higher risk of IR after adjusting for other risk factors (odds ratio 1.523 [1.272-2.009]). However, there was no significant difference in insulin secretion between the two groups. With the use of the multiple linear regression model, waist circumference (WC) and triglycerides (TGs) were found to be independent risk factors of the decline of insulin sensitivity in FHD(+) subjects, and insulin sensitivity declined significantly (P<0.05) with the increase of WC and TGs. In addition, the offspring of fathers with diabetes (PT2D) were much older and had higher TC than those of mothers with diabetes (MT2D). After adjusting for gender of the parents, there was no difference between MT2D and PT2D on insulin sensitivity.
  
  
  CONCLUSIONS
  Inheritance if diabetes is associated with the decline of insulin sensitivity. In addition, insulin sensitivity declined with increasing WC and TG in FHD(+) subjects.
authors.affiliation: Department of Endocrinology, Fujian Provincial Hospital, Fujian Medical University, Fuzhou, China. chengang18@yahoo.com
authors.forename: Gang
authors.initials: G
authors.lastname: Chen
authors.forename: Meizhi
authors.initials: M
authors.lastname: Li
authors.forename: Yuan
authors.initials: Y
authors.lastname: Xu
authors.forename: Nianhui
authors.initials: N
authors.lastname: Chen
authors.forename: Huibin
authors.initials: H
authors.lastname: Huang
authors.forename: Jixing
authors.initials: J
authors.lastname: Liang
authors.forename: Liantao
authors.initials: L
authors.lastname: Li
authors.forename: Junping
authors.initials: J
authors.lastname: Wen
authors.forename: Lixiang
authors.initials: L
authors.lastname: Lin
authors.forename: Jin
authors.initials: J
authors.lastname: Yao
mesh_terms: D000328:Adult; D000465:Algorithms; D044466:Asian People; D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D002681:China / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000453:epidemiology* / Q000503:physiopathology; D005192:Family Health; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D050417:Insulin-Secreting Cells / Q000378:metabolism*; D016014:Linear Models; D008297:Male; D050177:Overweight / Q000097:blood / Q000453:epidemiology / Q000378:metabolism; D012307:Risk Factors; D011795:Surveys and Questionnaires; D014280:Triglycerides / Q000097:blood; D055105:Waist Circumference
chemical_list: D001786:Blood Glucose; D007328:Insulin; D014280:Triglycerides