title: From methylene blue to chloroquine: a brief review of the development of an antimalarial therapy.
abstract: Malarial treatment is widely and readily available today. However, there was a time in the not-so-distant past when malaria was a deadly disease with no known cause or cure. In this article, we trace the origins of an antimalarial therapy from the discovery of the nature of the malarial parasite through the development of chloroquine. We dedicate this article to Johann "Hans" Andersag, the scientist who developed chloroquine, on the 110th anniversary of his birth, 16 February 1902.
authors.affiliation: Department of Pathology, University of Minnesota School of Medicine, Duluth, MN, USA. kristinekrafts@gmail.com
authors.forename: Kristine
authors.initials: K
authors.lastname: Krafts
authors.forename: Ernst
authors.initials: E
authors.lastname: Hempelmann
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Skórska-Stania
mesh_terms: D000962:Antimalarials / Q000627:therapeutic use*; D002738:Chloroquine / Q000627:therapeutic use*; D004358:Drug Therapy / Q000266:history / Q000639:trends; D049672:History, 19th Century; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D008288:Malaria / Q000188:drug therapy*; D008751:Methylene Blue / Q000627:therapeutic use*
chemical_list: D000962:Antimalarials; D002738:Chloroquine; D008751:Methylene Blue