title: Smoking dose modifies the association between C242T polymorphism and prevalence of metabolic syndrome in a Chinese population.
abstract: BACKGROUND
  The C242T polymorphism of the CYBA gene that encodes p22phox, a component of NADPH oxidase, has been found to modulate superoxide production. Oxidase is a major source of the superoxide anion that contributes to individual components of metabolic syndrome. We examined the relationship of the C242T polymorphism with the prevalence of metabolic syndrome in a Chinese population, taking account of consumed cigarette amounts.
  
  
  RESULTS
  In 870 participants, we collected biomarkers related to metabolic syndrome and detailed history of smoking and genotyped the C242T polymorphisms. After adjustment for covariates, the CT/TT genotypes were associated with a lower risk of metabolic syndrome (P = 0.0008). The odds of having metabolic syndrome in the CT/TT participants were 0.439 (95%CI: 0.265, 0.726), while for CC participants the odds were 1.110 (95%CI: 0.904, 1.362). There was significant (P = 0.014) interaction between the C242T polymorphism and smoking status in relation to the prevalence of metabolic syndrome. For smokers who smoke no less than 25 pack-years, those with CT/TT genotypes had lower risk of metabolic syndrome as compared with CC polymorphism carriers (P = 0.015). In the multiple regression analysis, the CT/TT genotypes were significantly associated with lower serum concentration of triglycerides both in all subjects and smokers; furthermore, the CT/TT genotypes were also related to smaller waist circumference in smokers.
  
  
  CONCLUSIONS
  Our study suggests that the C242T gene polymorphism is indeed related to the prevalence of metabolic syndrome and smoking dose might modify this association.
authors.affiliation: Department of Cardiology, Changzhou Second People's Hospital, Affiliated Nanjing Medical University, Changzhou, China.
authors.forename: Jiyong
authors.initials: J
authors.lastname: Ge
authors.forename: Zhijian
authors.initials: Z
authors.lastname: Ding
authors.forename: Yu
authors.initials: Y
authors.lastname: Song
authors.forename: Fangfang
authors.initials: F
authors.lastname: Wang
mesh_terms: D000328:Adult; D002681:China; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000208:ethnology / Q000209:etiology / Q000235:genetics*; D008875:Middle Aged; D019255:NADPH Oxidases / Q000235:genetics*; D016017:Odds Ratio; D011110:Polymorphism, Genetic; D015995:Prevalence; D012306:Risk; D012907:Smoking
chemical_list: D019255:NADPH Oxidases; C086986:CYBA protein, human