title: [Macrolide-resistant Mycoplasma pneumoniae].
abstract: Mycoplasma pneumoniae (M. pn) is one of the main pathogens causing community-acquired pneumonia (CAP) in children. In Japan, macrolide (ML)-resistant M. pn was firstly isolated from clinical samples collected from pediatric patients with CAP in 2000, and the agents have rapidly increased. All ML-resistant strains had a point mutation in domain V of the 23S rRNA. Among the patients with ML-resistant M. pn, the duration of fever was significantly longer than in patients with ML-susceptible M. pn infection. The antimicrobial agent was often changed from ML as a first choice agent to minocycline or levofloxacin, because of unimproved clinical symptoms. Further clinical studies are needed to establish appropriate chemotherapy.
authors.affiliation: Laboratory of Molecular Epidemiology for Infectious Agents, Kitasato Institute for Life Sciences, Kitasato University.
authors.forename: Miyuki
authors.initials: M
authors.lastname: Morozumi
authors.forename: Kimiko
authors.initials: K
authors.lastname: Ubukata
mesh_terms: D002648:Child; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D006801:Humans; D018942:Macrolides / Q000494:pharmacology*; D009177:Mycoplasma pneumoniae / Q000187:drug effects* / Q000235:genetics; D011019:Pneumonia, Mycoplasma / Q000382:microbiology
chemical_list: D018942:Macrolides