title: Primate segmental duplication creates novel promoters for the LRRC37 gene family within the 17q21.31 inversion polymorphism region.
abstract: The LRRC37 gene family maps to a complex region of the human genome and has been subjected to multiple rounds of segmental duplication. We investigate the expression and regulation of this gene family in multiple tissues and organisms and show a testis-specific expression of this gene family in mouse but a more ubiquitous pattern of expression among primates. Evolutionary and phylogenetic analyses support a model in which new alternative promoters have been acquired during primate evolution. We identify two promoters, Cl8 and particularly Cl3, both of which are highly active in the cerebellum and fetal brain in human and have been duplicated from a promoter region of two unrelated genes, BPTF and DND1, respectively. Two of these more broadly expressed gene family members, LRRC37A1 and A4, define the boundary of a common human inversion polymorphism mapping to chromosome 17q21.31 (the MAPT locus)-a region associated with risk for frontal temporal dementia, Parkinsonism, and intellectual disability. We propose that the regulation of the LRRC37 family occurred in a stepwise manner, acquiring foreign promoters from BPTF and DND1 via segmental duplication. This unusual evolutionary trajectory altered the regulation of the LRRC37 family, leading to increased expression in the fetal brain and cerebellum.
authors.affiliation: Swiss Institute of Allergy and Asthma Research, Davos, Switzerland. cemalettin.bekpen@boun.edu.tr
authors.forename: Cemalettin
authors.initials: C
authors.lastname: Bekpen
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Tastekin
authors.forename: Priscillia
authors.initials: P
authors.lastname: Siswara
authors.forename: Cezmi A
authors.initials: CA
authors.lastname: Akdis
authors.forename: Evan E
authors.initials: EE
authors.lastname: Eichler
mesh_terms: D000818:Animals; D034961:Antigens, Nuclear / Q000235:genetics; D001921:Brain / Q000196:embryology / Q000502:physiology; D007446:Chromosome Inversion; D002886:Chromosomes, Human, Pair 17; D019143:Evolution, Molecular; D015870:Gene Expression; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D005810:Multigene Family; D009363:Neoplasm Proteins / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000235:genetics; D009928:Organ Specificity / Q000235:genetics; D010802:Phylogeny; D011110:Polymorphism, Genetic; D011323:Primates / Q000235:genetics*; D011401:Promoter Regions, Genetic; D056916:Segmental Duplications, Genomic; D013737:Testis / Q000502:physiology; D014157:Transcription Factors / Q000235:genetics; D000092468:Bromodomain Containing Proteins
chemical_list: D034961:Antigens, Nuclear; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins; D014157:Transcription Factors; C528453:Dnd1 protein, human; C406238:fetal Alzheimer antigen; D000092468:Bromodomain Containing Proteins