title: Europium(III) DOTA-tetraamide complexes as redox-active MRI sensors.
abstract: PARACEST redox sensors containing the NAD(+)/NADH mimic N-methylquinolinium moiety as a redox-active functional group have been designed and synthesized. The Eu(3+) complex with two quinolinium moieties was nearly completely CEST-silent in the oxidized form but was "turned on" upon reduction with β-NADH. The CEST effect of the Eu(3+) complex containing only one quinolinium group was much less redox-responsive but showed an unexpected sensitivity to pH in the physiologically relevant pH range.
authors.affiliation: Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.
authors.forename: S James
authors.initials: SJ
authors.lastname: Ratnakar
authors.forename: Subha
authors.initials: S
authors.lastname: Viswanathan
authors.forename: Zoltan
authors.initials: Z
authors.lastname: Kovacs
authors.forename: Ashish K
authors.initials: AK
authors.lastname: Jindal
authors.forename: Kayla N
authors.initials: KN
authors.lastname: Green
authors.forename: A Dean
authors.initials: AD
authors.lastname: Sherry
mesh_terms: D000577:Amides / Q000737:chemistry*; D005063:Europium / Q000737:chemistry*; D006573:Heterocyclic Compounds, 1-Ring / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry*; D010084:Oxidation-Reduction
chemical_list: D000577:Amides; D006573:Heterocyclic Compounds, 1-Ring; D009942:Organometallic Compounds; C071349:1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid; D005063:Europium