title: Is MMP-7 gene polymorphism a possible risk factor for chronic obstructive pulmonary disease in Turkish patients.
abstract: Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease that leads to fixed narrowing of small airways and alveolar wall destruction (emphysema). This study was performed to test the association between MMP-7 (rs155668818) and MMP-12 (rs56184183) polymorphisms in the MMP-7 gene and COPD risk and its severity in the Turkish population. MMP-7 and MMP-12 polymorphisms were genotyped in 85 patients with COPD and 73 healthy control subjects using real-time polymerase chain reaction analysis. There were significant differences in the distribution of MMP-7 genotypes but not in the frequencies of these alleles between COPD patients and controls (p=0.009, p=0.102, respectively). The MMP-7 AA genotype was found to be associated with an increased risk of COPD (p=0.004; odds ratio: 2.576; confidence interval: 1.297-5.119). The lowest values of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), FEV1/FVC in patients with GG homozygosity were determined and these values were statistically significant compared to the control subjects (p<0.001, p<0.001, p<0.001). When the present study groups were analyzed for MMP-12 polymorphism, it was found that all the subjects had wild-type genotype for this polymorphism. These findings have suggested that MMP-7 polymorphism might be associated with the risk and progression of COPD in the Turkish population.
authors.affiliation: Yedikule Chest Diseases and Chest Surgery, Training and Research Hospital, Istanbul, Turkey.
authors.forename: Umit
authors.initials: U
authors.lastname: Mogulkoc
authors.forename: Ender
authors.initials: E
authors.lastname: Coskunpinar
authors.forename: Engin
authors.initials: E
authors.lastname: Aynaci
authors.forename: Emel
authors.initials: E
authors.lastname: Cağlar
authors.forename: Mediha Gonenc
authors.initials: MG
authors.lastname: Ortakoylu
authors.forename: Gokhan
authors.initials: G
authors.lastname: Ozkan
authors.forename: Yasemin Musteri
authors.initials: YM
authors.lastname: Oltulu
authors.forename: Ilhan Yaylim
authors.initials: IY
authors.lastname: Eraltan
mesh_terms: D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D020783:Matrix Metalloproteinase 7 / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic; D029424:Pulmonary Disease, Chronic Obstructive / Q000235:genetics* / Q000503:physiopathology; D012307:Risk Factors; D012720:Severity of Illness Index; D014421:Turkey
chemical_list: D020783:Matrix Metalloproteinase 7