title: The automatic annotation of bacterial genomes.
abstract: With the development of ultra-high-throughput technologies, the cost of sequencing bacterial genomes has been vastly reduced. As more genomes are sequenced, less time can be spent manually annotating those genomes, resulting in an increased reliance on automatic annotation pipelines. However, automatic pipelines can produce inaccurate genome annotation and their results often require manual curation. Here, we discuss the automatic and manual annotation of bacterial genomes, identify common problems introduced by the current genome annotation process and suggests potential solutions.
authors.affiliation: The Roslin Institute, University of Edinburgh, Easter Bush, EH25 9RG, UK.
authors.forename: Emily J
authors.initials: EJ
authors.lastname: Richardson
authors.forename: Mick
authors.initials: M
authors.lastname: Watson
mesh_terms: D019295:Computational Biology / Q000379:methods*; D030541:Databases, Genetic; D004926:Escherichia coli / Q000235:genetics; D016680:Genome, Bacterial; D058977:Molecular Sequence Annotation / Q000379:methods*; D012475:Salmonella / Q000235:genetics; D012984:Software