title: Acidic polysaccharide extracts from Gastrodia Rhizomes suppress the atherosclerosis risk index through inhibition of the serum cholesterol composition in Sprague Dawley rats fed a high-fat diet.
abstract: Obesity is associated with a broad spectrum of cardio-metabolic disturbances, including atherosclerosis and cardiovascular disease (CDV). A high-fat diet has been shown to cause an elevation of the plasma cholesterol levels in humans, and the control of serum cholesterol has been demonstrated to be important in the prevention of CVD and atherosclerosis. The aims of this study were to demonstrate that crude and acidic polysaccharide extracts from Gastrodia rhizomes suppress atherosclerosis through the regulation of serum lipids in Sprague Dawley (SD) rats fed a high-fat diet. We examined the concentrations of serum lipids, including total cholesterol, triglycerides, high-density lipoproteins (HDL) cholesterol, and low-density lipoproteins (LDL) cholesterol, in SD rats fed a high-fat diet and evaluated the atherogenic index. Here, we show that both crude and acidic polysaccharide extracts from Gastrodia rhizomes inhibited the total cholesterol and LDL levels. Moreover, there was a significantly suppressed atherosclerosis risk due to the acidic polysaccharide extract from Gastrodia rhizome. Taken together, our results suggested that acidic polysaccharide extracts from Gastrodia rhizomes might be beneficial for lowering the incidence of CVD and atherosclerosis by reducing the de novo synthesis of total cholesterol and the LDL levels.
authors.affiliation: Department of Cancer and Cell Biology, University of Cincinnati Medical Center, Cincinnati, OH 45267, USA.
authors.forename: Kui-Jin
authors.initials: KJ
authors.lastname: Kim
authors.affiliation: Department of Food Science and Biotechnology, Kangwon National University, Chuncheon 200-701, Korea.
authors.forename: Ok-Hwan
authors.identifier: 0000-0001-6855-3136
authors.initials: OH
authors.lastname: Lee
authors.affiliation: Korea Food Research Institute, Seongnam, Kyonggi 463-746, Korea.
authors.forename: Chan-Kyu
authors.initials: CK
authors.lastname: Han
authors.affiliation: Korea Food Research Institute, Seongnam, Kyonggi 463-746, Korea.
authors.forename: Young-Chan
authors.initials: YC
authors.lastname: Kim
authors.affiliation: Korea Food Research Institute, Seongnam, Kyonggi 463-746, Korea.
authors.forename: Hee-Do
authors.initials: HD
authors.lastname: Hong
mesh_terms: D000818:Animals; D050197:Atherosclerosis / Q000097:blood / Q000139:chemically induced / Q000517:prevention & control; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D004041:Dietary Fats / Q000009:adverse effects* / Q000494:pharmacology; D031668:Gastrodia / Q000737:chemistry*; D006801:Humans; D008297:Male; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D011134:Polysaccharides / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D027343:Rhizome / Q000737:chemistry*; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004041:Dietary Fats; D010936:Plant Extracts; D011134:Polysaccharides; D014280:Triglycerides