title: Integration of B cell responses through Toll-like receptors and antigen receptors.
abstract: Unlike other immune cells, B cells express both an antigen-specific B cell receptor (BCR) and Toll-like receptors (TLRs). Dual BCR and TLR engagement can fine-tune functional B cell responses, directly linking cell-intrinsic innate and adaptive immune programmes. Although most data regarding B cell-specific functions of the TLR signalling pathway have been obtained in mice, the discovery of patients with a deficiency in this pathway has recently provided an insight into human B cell responses. Here, we highlight the importance of the integration of signalling pathways downstream of BCRs and TLRs in modulating B cell function, focusing when possible on B cell-intrinsic roles.
authors.affiliation: Department of Pediatrics, University of Washington School of Medicine, Seattle, Washington 98195, USA. drawling@u.washington.edu
authors.forename: David J
authors.initials: DJ
authors.lastname: Rawlings
authors.forename: Marc A
authors.initials: MA
authors.lastname: Schwartz
authors.forename: Shaun W
authors.initials: SW
authors.lastname: Jackson
authors.forename: Almut
authors.initials: A
authors.lastname: Meyer-Bahlburg
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D011947:Receptors, Antigen, B-Cell / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*; D051193:Toll-Like Receptors / Q000276:immunology*
chemical_list: D011947:Receptors, Antigen, B-Cell; D051193:Toll-Like Receptors