title: Seroprevalence of Bordetella pertussis immunoglobulin G antibodies among children in Samsun, Turkey.
abstract: In this study, we aimed to investigate anti-pertussis immunoglobulin (Ig) G antibodies in the serum of children in our region vaccinated against pertussis with four doses. Between August 2008-2009, antibody levels to Bordetella pertussis (B. pertussis) antigens were studied in 385 serum samples from healthy children aged 1.5-18 years (y) vaccinated against pertussis in Samsun, Turkey. The study population was divided into six groups according to ages: 1.5-3 y; 4-5 y; 6-8 y; 10-12 y; 13-15 y; and 16-18 y. IgG antibodies to B. pertussis antigens were measured with a commercial ELISA kit. Mean age of the children was 9.6 +/- 5.3 y. Anti-pertussis IgG titers were positive in 48.3% of the cases. The lowest positivity rate was determined in the 4-5 y age group (28.1%) and the highest rate in the 16-18 y age group (64.2%). Geometric mean titer of anti-pertussis antibodies was 39.2 IU/ml, and again the lowest value was obtained in the 4-5 y age group (23.3 IU/ml) and the highest in the 16-18 y age group (51.4 IU/ml). The antibody levels to B. pertussis antigens significantly decrease 4-6 years after vaccination and again increase in school children, possibly due to natural infection.
authors.affiliation: Division of Pediatric Infectious Diseases, Ondokuz Mayis University Faculty of Medicine, Samsun, Turkey.
authors.forename: Atay
authors.initials: A
authors.lastname: Ozkal
authors.forename: Gülnar
authors.initials: G
authors.lastname: Sensoy
authors.forename: Cağatay
authors.initials: C
authors.lastname: Acuner
authors.forename: Nurşen
authors.initials: N
authors.lastname: Belet
authors.forename: Akif Koray
authors.initials: AK
authors.lastname: Güney
mesh_terms: D000293:Adolescent; D001886:Bordetella pertussis / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007223:Infant; D008297:Male; D010567:Pertussis Vaccine / Q000008:administration & dosage; D016036:Seroepidemiologic Studies; D018709:Statistics, Nonparametric; D014421:Turkey / Q000453:epidemiology; D014917:Whooping Cough / Q000453:epidemiology* / Q000276:immunology* / Q000517:prevention & control
chemical_list: D007074:Immunoglobulin G; D010567:Pertussis Vaccine