title: Copper-free asymmetric allylic alkylation using grignard reagents on bifunctional allylic bromides.
abstract: A series of substrates containing a vinylic bromide were employed in a copper-free methodology using bidendate NHC ligands. The desired compounds are generally obtained with good enantioselectivity and good regioselectivity. Importantly the copper-catalyzed system afforded a lower enantioselectivity value. The catalytic products could be transformed into a broad scope of new 1,1-disubstituted olefins in a single step transformation without erosion of the enantioselectivity.
authors.affiliation: Department of Organic Chemistry, University of Geneva, 30 quai Ernest Ansermet CH-1211 Geneva 4, Switzerland.
authors.forename: David
authors.initials: D
authors.lastname: Grassi
authors.forename: Alexandre
authors.initials: A
authors.lastname: Alexakis