title: Left atrial volume index as a predictor of ventricle repolarization abnormalities in adult dialyzed patients.
abstract: This study was performed to investigate the relationship between left atrium (LA) volume index (LAVI) and left ventricle electrical activity presumably repolarization in end-stage renal disease patients. Study group was consisted of 120 dialyzed patients divided into two subgroups: 57 (age 50.7 ± 7.1) were on continuous ambulatory peritoneal dialysis (CAPD) and 73 (age 51.6 ± 7.6) were hemodialyzed (HD). All patients were undergoing three-dimensional vectorcardiographic (VCG) monitoring to assess parameters concerning T vector: QRS-T angle, Tel, and Taz. Standard echocardiography was performed to assess: LAmax, LAshort, LAlong. LAVI was calculated due to formula: LAVI = (π/6X [LAmax × LAshort × LAlong])/m2. LAVI in HD as well as in CAPD patients was significantly higher compared with controls (respectively: 36.29 ± 10.92; 36.41 ± 11.06; 20.64 ± 6.77 mL/m2). The calculated cutoff value of LAVI was 36.32 mL/m2. In HD patients, the strong correlations between LAVI and QRS-T angle and Tel were determined (respectively: r = 0.407, P < 0.001 and r = 0.359, P = 0.006). Similarly in CAPD group were significant associations between LAVI and QRS-T angle and Tel (respectively: r = 0.423, P < 0.001 and r = 0.374, P = 0.004). The QRS-T angle, Tel and Taz are independently and markedly associated with LAVI in both HD and CAPD patients. LAVI and VCG indices are higher in both HD and CAPD patients. Correlation between QRS-T angle and LAVI may reflect unfavorable influence on the electrical activity of the heart in dialyzed patients with left ventricle diastolic dysfunction. LAVI cutoff value is useful biomarker for stratification of ventricle repolarization disturbances in those patients.
authors.affiliation: Chair and Department of Cardiology, Medical University of Lublin, Lublin, Poland. zapolia@wp.pl
authors.forename: Tomasz
authors.initials: T
authors.lastname: Zapolski
authors.forename: Andrzej
authors.initials: A
authors.lastname: Jaroszyński
authors.forename: Anna
authors.initials: A
authors.lastname: Drelich-Zbroja
authors.forename: Jacek
authors.initials: J
authors.lastname: Furmaga
authors.forename: Andrzej
authors.initials: A
authors.lastname: Wysokiński
authors.forename: Andrzej
authors.initials: A
authors.lastname: Książek
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Szczerbo-Trojanowska
authors.forename: Sławomir
authors.initials: S
authors.lastname: Rudzki
mesh_terms: D004452:Echocardiography; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006325:Heart Atria / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000000981:diagnostic imaging / Q000503:physiopathology*; D007676:Kidney Failure, Chronic / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000009:adverse effects / Q000379:methods*; D020257:Ventricular Remodeling / Q000502:physiology*