title: Comparison between topical honey and mafenide acetate in treatment of burn wounds.
abstract: Histological and clinical studies of wound healing were performed in comparable cases of fresh partial-thickness burns treated with honey dressing or mafenide acetate in two groups of 50 randomly allocated patients. Of the patients with honey-treated wounds, 84% showed satisfactory epithelialization by day 7 and 100% by day 21. In wounds treated with mafenide acetate, epithelialization occurred by day 7 in 72% of cases and in 84% by day 21. Histological evidence of reparative activity was observed in 80% of wounds treated with honey dressing by day 7 with minimal inflammation. Fifty-two per cent of the mafenide acetate treated wounds showed reparative activity with inflammatory changes by day 7. Reparative activity reached 100% by day 21 with the honey dressing and 84% with mafenide acetate. Thus, in honey-dressed wounds, early subsidence of acute inflammatory changes, better control of infection, and quicker wound healing were observed, while in mafenide acetate treated wounds a sustained inflammatory reaction was noted even on epithelialization.
authors.affiliation: Department of Surgery, Faculty of Medicine, University of Medical Sciences of Tabriz, Iran.
authors.forename: H
authors.initials: H
authors.lastname: Maghsoudi
authors.forename: F
authors.initials: F
authors.lastname: Salehi
authors.forename: M K
authors.initials: MK
authors.lastname: Khosrowshahi
authors.forename: M
authors.initials: M
authors.lastname: Baghaei
authors.forename: M
authors.initials: M
authors.lastname: Nasirzadeh
authors.forename: R
authors.initials: R
authors.lastname: Shams