title: Pathogenesis and management of pruritus in cholestatic liver disease.
abstract: Patients with cholestatic liver diseases such as primary biliary cirrhosis, primary sclerosing cholangitis and intrahepatic cholestasis of pregnancy commonly complain of pruritus. The underlying pathogenesis remains obscure with several mediators possibly playing an important role; these include lysophosphatidic acid, bile salts, opioids, histamine and progesterone metabolites. We describe in this review novel insights into the pathogenesis and management of pruritus in patients with cholestasis.
authors.affiliation: Division of Gastroenterology and Hepatology, Mayo Clinic Rochester, Rochester, MN 55905, USA.
authors.forename: Mohamad H
authors.initials: MH
authors.lastname: Imam
authors.forename: Andrea A
authors.initials: AA
authors.lastname: Gossard
authors.forename: Emmanouil
authors.initials: E
authors.lastname: Sinakos
authors.forename: Keith D
authors.initials: KD
authors.lastname: Lindor
mesh_terms: D000982:Antipruritics / Q000627:therapeutic use*; D002780:Cholestasis, Intrahepatic / Q000150:complications* / Q000453:epidemiology; D006801:Humans; D009434:Neural Pathways / Q000503:physiopathology; D011537:Pruritus / Q000188:drug therapy* / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology
chemical_list: D000982:Antipruritics