title: Acute oral toxicity evaluations of some zinc(II) complexes derived from 1-(2-salicylaldiminoethyl)piperazine Schiff bases in rats.
abstract: The current study described the synthesis and the in vivo acute oral toxicity evaluations in Sprague Dawley rats. The compounds were characterized by elemental analyses, LC-MS, FTIR, (1)H NMR, (13)C NMR and UV-visible spectroscopy. In the acute toxicity study, a single administration of the compounds was performed orally to the rats at the single doses of 2000 mg/kg and they were then monitored for possible side effects, mortality or behavioral changes up to 14 days. The serum level of aspartate (AST), alanine aminotransferases (ALT), alkaline phosphate (ALP), triglyceride, high density lipoprotein (HDL), immunoglobulins (GAM) and the C-reactive proteins did not significantly change. The hematological indices white blood cells (WBC), haematocrit (HCT), red blood cells (RBC), mean corpuscular volume (MCV), mean corpuscular haemoglobin concentration (MCHC), and mean corpuscular hemoglobin (MCH) were within the normal range. The renal function indices examined were also within the reference range. Generally, the compounds exhibited low toxic effects as required for further in vivo therapeutic studies.
authors.affiliation: Department of Chemistry, University of Malaya, Kuala Lumpur 50603, Malaysia.
authors.forename: Muhammad Saleh
authors.initials: MS
authors.lastname: Salga
authors.affiliation: Department of Chemistry, University of Malaya, Kuala Lumpur 50603, Malaysia.
authors.forename: Hapipah Mohd
authors.initials: HM
authors.lastname: Ali
authors.affiliation: Department of Molecular Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia.
authors.forename: Mahmood Ameen
authors.initials: MA
authors.lastname: Abdulla
authors.affiliation: Department of Pharmacy, University of Malaya, Kuala Lumpur 50603, Malaysia.
authors.forename: Siddig Ibrahim
authors.initials: SI
authors.lastname: Abdelwahab
mesh_terms: D000284:Administration, Oral; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001224:Aspartic Acid / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004909:Erythrocyte Indices; D005260:Female; D007136:Immunoglobulins / Q000097:blood; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D010879:Piperazines / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012545:Schiff Bases / Q000633:toxicity; D013997:Time Factors; D014280:Triglycerides / Q000097:blood; D015032:Zinc / Q000633:toxicity*
chemical_list: D007136:Immunoglobulins; D008075:Lipoproteins, HDL; D010879:Piperazines; D012545:Schiff Bases; D014280:Triglycerides; D001224:Aspartic Acid; D002097:C-Reactive Protein; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D015032:Zinc