title: From heart to brain: the genesis and processing of cardiac pain.
abstract: Angina pectoris is important because of its association with heart disease and risk of death. Historically after Heberden's account of angina in 1772, the association of pain with coronary artery disease quickly followed. Within a few years, Burns suggested an etiological role for ischemia. Subsequently, theories of differential myocardial stretch dominated thinking until Lewis' chemical hypothesis in 1932, in which the local release of chemical substances during ischemia was seen as the cause of pain. This review considers how ischemia at the tissue level triggers activation of afferent nociceptive pain fibres. The afferent projections of sympathetic and vagal afferent fibres are described, with a number of methodologies cited (eg, injection of pseudorabies virus into the heart with mapping of the retrograde viral transport pathways; and elevation of neuronal c-fos synthesis in brain regions activated by capsaicin application to the heart). Our own functional neuroimaging studies of angina are also reviewed. There are 2 intriguing features of angina. The first is the poor correlation between symptoms and extent of coronary disease. The spectrum ranges from entirely silent myocardial ischemia to that of a functional pain syndrome--the 'sensitive heart'--of cardiac syndrome X. An even more difficult aspect is the wide variability in symptoms experienced by an individual patient. A new paradigm is presented which, besides considering myocardial oxygen supply/demand imbalance, also draws insights from the broader field of pain research. Neuromodulation applies at multiple levels of the neuraxis--peripheral nerves, spinal cord, and brain--and it invites exploitation, whether pharmacological or electrical, for the benefit of the cardiac patient in pain.
authors.affiliation: National Heart and Lung Institute, Imperial College, London, United Kingdom. stuart.rosen@imperial.ac.uk
authors.forename: Stuart D
authors.initials: SD
authors.lastname: Rosen
mesh_terms: D000787:Angina Pectoris / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology / Q000523:psychology; D000818:Animals; D001921:Brain / Q000378:metabolism / Q000503:physiopathology; D003863:Depression / Q000150:complications / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D059907:Functional Neuroimaging / Q000379:methods*; D006321:Heart / Q000294:innervation / Q000503:physiopathology; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D023421:Models, Animal; D008955:Models, Cardiovascular; D017202:Myocardial Ischemia / Q000150:complications / Q000378:metabolism / Q000503:physiopathology; D009434:Neural Pathways / Q000378:metabolism / Q000503:physiopathology; D059226:Nociceptive Pain / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D011619:Psychotropic Drugs / Q000494:pharmacology; D016032:Randomized Controlled Trials as Topic; D014630:Vagus Nerve / Q000378:metabolism / Q000503:physiopathology; D014666:Vasomotor System / Q000378:metabolism / Q000503:physiopathology
chemical_list: D011619:Psychotropic Drugs