title: Tumor markers and biochemical parameters in colon cancer patients before and after chemotherapy.
abstract: OBJECTIVE
  Tumor markers and biochemical parameters were investigated in patients suffering from colon cancer and in volunteer healthy persons.
  
  
  METHODS
  Biochemical analyses of erythrocyte enzymes and serum values for series of established tumor markers were conducted for 40 patients diagnosed with colon cancer, before and after chemotherapy, and 29 healthy volunteers between 2008 and 2009.
  
  
  RESULTS
  Activities of catalase and carbonic anhydrase were lower in sick than healthy groups (p<0.05) before and after chemotherapy, while alkaline phosphatase and creatinine were increased. The patients with colon cancer showed significant (p<0.05) elevation of CRP, fibrinogen, CA125, AFP, and decrease in ferritinin, before but not after therapy.
  
  
  CONCLUSIONS
  The results obtaining from this investigation can be useful for colon cancer risk assessment.
authors.affiliation: Division of Biochemistry, Health Sciences Faculty, Yuzuncu Yil University, Van, Turkey. gurtugba@hotmail.com
authors.forename: Tuğba
authors.initials: T
authors.lastname: Gür
authors.forename: Halit
authors.initials: H
authors.lastname: Demir
authors.forename: M Çetin
authors.initials: MÇ
authors.lastname: Kotan
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood* / Q000235:genetics / Q000378:metabolism; D002097:C-Reactive Protein / Q000032:analysis; D018394:CA-125 Antigen / Q000097:blood; D002256:Carbonic Anhydrases / Q000097:blood; D016022:Case-Control Studies; D002374:Catalase / Q000096:biosynthesis / Q000097:blood; D003110:Colonic Neoplasms / Q000097:blood* / Q000188:drug therapy / Q000235:genetics / Q000378:metabolism; D003404:Creatinine / Q000097:blood; D005293:Ferritins / Q000096:biosynthesis / Q000097:blood; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D008565:Membrane Proteins / Q000097:blood; D018384:Oxidative Stress; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; C451759:MUC16 protein, human; D008565:Membrane Proteins; D000509:alpha-Fetoproteins; D005340:Fibrinogen; D002097:C-Reactive Protein; D005293:Ferritins; D003404:Creatinine; D002374:Catalase; D000469:Alkaline Phosphatase; D002256:Carbonic Anhydrases