title: The efficiency of proanthocyanidin in an experimental pulmonary fibrosis model: comparison with taurine.
abstract: Pulmonary fibrosis (PF) is a progressive fatal disorder. Bleomycin (BLM) is a widely used chemotherapeutic agent causing PF. Numerous agents have been investigated to prevent the progression of PF so far, but there is still a need to find more efficacious agents. Proanthocyanidin (PA) is a strong antioxidant, the main ingredient of grape seed extract. Since PA is ready for use in practice, we aimed to compare the preventive effect of PA in comparison with taurine (Tau) in BLM-induced PF. Forty Wistar male albino rats were used in the study and were divided into four groups: group 1, control; group 2, BLM-induced PF group; group 3, BLM-induced PF and treated with PA group; and group 4, BLM-induced PF and treated with Tau group. Treatments were begun 10 days before and continued 21 days after BLM injection. PA and Tau effectively inhibited inflammation, edema, severity of fibrosis, fibrosis extension, inflammatory cell accumulation, iNOS staining, and hydroxyproline level as well (p < 0.05). Total histological scores of the PA group were similar to the control group; Tau was significantly higher than the control group but lower than the BLM group (p < 0.05). We believe that PA could be a new treatment choice for PF, but further studies need to be conducted to verify the findings of the current study.
authors.affiliation: Department of Pathology, Ataturk Chest Diseases and Thoracic Surgery Training and Research Hospital, Kecioren, Ankara, Turkey.
authors.forename: Yetkin
authors.initials: Y
authors.lastname: Agackiran
authors.forename: Husamettin
authors.initials: H
authors.lastname: Gul
authors.forename: Ersin
authors.initials: E
authors.lastname: Gunay
authors.forename: Nalan
authors.initials: N
authors.lastname: Akyurek
authors.forename: Leyla
authors.initials: L
authors.lastname: Memis
authors.forename: Sibel
authors.initials: S
authors.lastname: Gunay
authors.forename: Yusuf Sinan
authors.initials: YS
authors.lastname: Sirin
authors.forename: Tayfun
authors.initials: T
authors.lastname: Ide
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001761:Bleomycin / Q000633:toxicity; D056604:Grape Seed Extract; D006909:Hydroxyproline / Q000096:biosynthesis; D007249:Inflammation / Q000188:drug therapy; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008214:Lymphocytes / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects; D008297:Male; D009504:Neutrophils / Q000187:drug effects; D052247:Nitric Oxide Synthase Type II / Q000096:biosynthesis; D044945:Proanthocyanidins / Q000494:pharmacology*; D011658:Pulmonary Fibrosis / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D013654:Taurine / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D056604:Grape Seed Extract; D044945:Proanthocyanidins; D001761:Bleomycin; C013221:proanthocyanidin; D013654:Taurine; D052247:Nitric Oxide Synthase Type II; D006909:Hydroxyproline