title: Clinical impact of intracoronary abciximab in patients undergoing primary percutaneous coronary intervention: an individual patient data pooled analysis of randomised studies.
abstract: OBJECTIVE
  The aim of this study was to perform an individual patient-level pooled analysis of randomised trials, comparing intracoronary versus intravenous abciximab bolus use in patients with ST-segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI).
  
  
  BACKGROUND
  Abciximab represents a cornerstone in the treatment of STEMI patients undergoing primary PCI. Intracoronary abciximab bolus administration has been proposed as an alternative strategy to the standard intravenous route. However, whether intracoronary abciximab effectively improves clinical outcomes compared with standard route remains unknown.
  
  
  METHODS
  Individual data of 1198 patients enrolled in five trials were entered into the pooled analysis. The primary endpoint of the study was the occurrence of all-cause death and reinfarction at 30-day follow-up. Secondary endpoints were all-cause death, reinfarction and target-vessel revascularisation (TVR).
  
  
  RESULTS
  No significant heterogeneity was found across trials. Compared with the intravenous route, intracoronary abciximab administration significantly reduced the risk of the composite of death and reinfarction (HR 0.52, 95% CI 0.29 to 0.94; p=0.03), death (HR 0.44, 95% CI 0.20 to 0.95; p=0.04) and TVR (HR 0.53, 95% CI 0.29 to 0.99; p=0.045), without a significant impact on the risk of reinfarction (HR 0.54, 95% CI 0.24 to 1.21; p=0.13). However, after correction for baseline differences, only the composite of death/reinfarction and death remained significant.
  
  
  CONCLUSIONS
  In STEMI patients undergoing primary PCI, intracoronary abciximab administration, when compared with the intravenous standard route, can improve short-term clinical outcomes mainly by reducing the risk of death.
authors.affiliation: Department of Clinical Medicine, Cardiovascular Sciences and Immunology, Federico II University, Naples, Italy.
authors.forename: Raffaele
authors.initials: R
authors.lastname: Piccolo
authors.forename: Youlan L
authors.initials: YL
authors.lastname: Gu
authors.forename: Allan Zeeberg
authors.initials: AZ
authors.lastname: Iversen
authors.forename: Alberto
authors.initials: A
authors.lastname: Dominguez-Rodriguez
authors.forename: Bart J G L
authors.initials: BJ
authors.lastname: de Smet
authors.forename: Karim D
authors.initials: KD
authors.lastname: Mahmoud
authors.forename: Ingo
authors.initials: I
authors.lastname: Eitel
authors.forename: Pedro
authors.initials: P
authors.lastname: Abreu-Gonzalez
authors.forename: Holger
authors.initials: H
authors.lastname: Thiele
authors.forename: Federico
authors.initials: F
authors.lastname: Piscione