title: Evaluation of placental syndecan-1 expression in early pregnancy as a predictive fetal factor for pregnancy outcome.
abstract: OBJECTIVE
  Early expression of syndecan-1, a regulator of growth factor and chemokine function, in animal and human abortuses or placenta at delivery suggests a potential role during embryonic development. The aim of this study was to examine the correlation between early placental syndecan expression and fetal outcome in ongoing pregnancies.
  
  
  METHODS
  Prospective immunohistochemical analysis of 203 chorionic villus sampling specimens obtained during a 4-year period (2001-2004). The chorionic villi were processed for paraffin-embedded immunohistochemistry. Scores of intensity of syndecan-1 expression in chorionic villi were correlated with maternal cofactors and pregnancy outcome.
  
  
  RESULTS
  Syndecan-1 immunostaining was significantly related to villus size, maternal tobacco use, and fetal biometry at ultrasonography. After correcting the above confounders, scores of syndecan-1 expression correlated with preterm birth and low birth weight.
  
  
  CONCLUSIONS
  Placental syndecan-1 expression is associated with premature birth and fetal growth.
authors.affiliation: Department of Gynecology and Obstetrics, Münster University Hospital, Albert-Schweitzer-Str. 33, D-48149, Münster, Germany.
authors.forename: Anna
authors.initials: A
authors.lastname: Schmedt
authors.forename: Martin
authors.initials: M
authors.lastname: Götte
authors.forename: Jörg
authors.initials: J
authors.lastname: Heinig
authors.forename: Ludwig
authors.initials: L
authors.lastname: Kiesel
authors.forename: Walter
authors.initials: W
authors.lastname: Klockenbusch
authors.forename: Johannes
authors.initials: J
authors.lastname: Steinhard
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000378:metabolism; D015193:Chorionic Villi Sampling; D005260:Female; D047109:Fetal Development / Q000502:physiology*; D020567:Fetal Weight; D006801:Humans; D007150:Immunohistochemistry; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D010920:Placenta / Q000378:metabolism*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011256:Pregnancy Outcome; D047928:Premature Birth; D011446:Prospective Studies; D053668:Syndecan-1 / Q000378:metabolism*; D016216:Ultrasonography, Prenatal; D055815:Young Adult
chemical_list: D015415:Biomarkers; C508241:SDC1 protein, human; D053668:Syndecan-1