title: The effect of different doses of an arginine-containing supplement on the healing of pressure ulcers.
abstract: OBJECTIVE
  To investigate if a lower dose of arginine in the form of an oral nutritional supplement can show similar benefit in the healing rate of pressure ulcers compared with the current evidence for 9g of arginine.
  
  
  METHODS
  Twenty-three inpatients with category II, III or IV pressure ulcers were randomised to receive daily, for 3 weeks, the standard hospital diet plus 4.5 or 9g arginine in the form of a commercial supplement. Pressure ulcer size and severity was measured weekly (by PUSH tool; pressure ulcer scale for healing; 0= completely healed, 17= greatest severity). Nutritional status was determined by Subjective Global Assessment.
  
  
  RESULTS
  There were no significant differences in patients' age, gender, BMI, haemoglobin levels, albumin levels and diagnosis of diabetes between treatment groups. There was a significant decrease in pressure ulcer severity over time (p < 0.001), with no evidence of a difference in healing rate between the two arginine dosages (p=0.991). Based on expected healing time, patients in both treatment groups were estimated to achieve an almost 2-fold improvement compared with the historical control group. Patients categorised as malnourished showed clinically significant impaired healing rates compared with well nourished patients (p=0.057), although this was unaffected by arginine dosage (p=0.727).
  
  
  CONCLUSIONS
  Similar clinical benefits in healing of pressure ulcers can be achieved with a lower dosage of arginine, which can translate into improved concordance and significant cost-savings for both the health-care facilities and for patients.
authors.affiliation: Dearkin University, Burwood, Australia.
authors.forename: B
authors.initials: B
authors.lastname: Leigh
authors.forename: K
authors.initials: K
authors.lastname: Desneves
authors.forename: J
authors.initials: J
authors.lastname: Rafferty
authors.forename: L
authors.initials: L
authors.lastname: Pearce
authors.forename: S
authors.initials: S
authors.lastname: King
authors.forename: M C
authors.initials: MC
authors.lastname: Woodward
authors.forename: D
authors.initials: D
authors.lastname: Brown
authors.forename: R
authors.initials: R
authors.lastname: Martin
authors.forename: T C
authors.initials: TC
authors.lastname: Crowe
mesh_terms: D000368:Aged; D001120:Arginine / Q000008:administration & dosage*; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D003668:Pressure Ulcer / Q000628:therapy*; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D001120:Arginine