title: Association of nutritional status, plasma, albumin levels and pulmonary function in cystic fibrosis.
abstract: OBJECTIVE
  Malnutrition is related with pulmonary disease. The aim was to analyze the association of lung function respectively to nutritional status, identified pulmonary pathogens and socioeconomic condition of patients attending a pediatric CF reference center.
  
  
  METHODS
  Cross-sectional study performed with CF patients aged 6 to 18 years attending a CF-Center in southern Brazil. Nutritional status, plasma albumin level and pulmonary bacterial colonization were assessed. The outcome studied was forced expiratory volume in 1 second (FEV1).
  
  
  RESULTS
  Eighty-five patients were included in this study. FEV1 was significantly associated with body mass index (BMI) percentiles, plasma albumin level and methicillin resistant Staphylococcus aureus (MRSA) pulmonary colonization. Regression analysis showed that BMI below the 10th percentile was associated with a 25.58% drop in FEV1, and plasma albumin levels equal to or lower than 4.1 mg/dL was associated with 18.6% FEV1 reduction. FEV1 was 14.4% lower in the MRSA infected patients. Plasma albumin of 4.25 mg/dL predicted FEV1 of 60% with 76.9% sensitivity and 72.2% specificity, and 85.7% accuracy. The socioeconomic status was not association with pulmonary function.
  
  
  CONCLUSIONS
  BMI below the 10th percentile and albumin below 4.1 mg/dL were predictors of low FEV1. Chronic MRSA infection was associated with lower FEV1. Longitudinal studies may better complement these results.
authors.affiliation: Serviço de Nutrição e Dietética, Centro de Estudos em Alimentação e Nutrição, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil. mjsantos@hcps.ufrgs.br
authors.forename: M I
authors.initials: MI
authors.lastname: Souza dos Santos Simon
authors.forename: M
authors.initials: M
authors.lastname: Drehmer
authors.forename: F A
authors.initials: FA
authors.lastname: de Abreu E Silva
authors.forename: A
authors.initials: A
authors.lastname: Hoffmann
authors.forename: C
authors.initials: C
authors.lastname: Druck Ricachinewsky
authors.forename: E
authors.initials: E
authors.lastname: de Fonseca Andrade Procianoy
authors.forename: I
authors.initials: I
authors.lastname: Scattolin
authors.forename: S
authors.initials: S
authors.lastname: Saldanha Menna Barreto
mesh_terms: D000293:Adolescent; D015992:Body Mass Index; D001938:Brazil; D002648:Child; D002908:Chronic Disease; D003430:Cross-Sectional Studies; D003550:Cystic Fibrosis / Q000097:blood* / Q000503:physiopathology*; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008171:Lung Diseases / Q000382:microbiology; D008297:Male; D044342:Malnutrition / Q000150:complications / Q000503:physiopathology; D055624:Methicillin-Resistant Staphylococcus aureus / Q000737:chemistry; D009752:Nutritional Status; D012129:Respiratory Function Tests; D018401:Sample Size; D012709:Serum Albumin / Q000032:analysis*; D012959:Socioeconomic Factors; D013203:Staphylococcal Infections / Q000097:blood / Q000503:physiopathology
chemical_list: D012709:Serum Albumin