title: Preparation and antimicrobial properties of gemini surfactant-supported triiodide complex system.
abstract: Iodine is an effective, simple, and inexpensive bactericide in disinfection. However, the poor solubility and stability of iodine in water limit its applications. In addition, the active iodine content in the commercial iodophors is quite low, and the reported triiodide complex is unstable. In this work, a long-term stable triiodide complex antimicrobial system was prepared by mixing iodine and a cationic gemini surfactant into lauryldimethylamine oxide (LDAO) aqueous solution, and its stability was examined by means of UV-vis spectrophotometry. It was found that the content of LDAO, cationic gemini surfactant and H(2)SO(4) played crucial roles in stabilizing antimicrobial system, and the active iodine (i.e., triiodide complex) content of the optimum formulation can remain stable for 150 days, as iodine is encapsulated by the mixed vesicles assembled by the protonated LDAO and the added gemini surfactant. However, the active iodine reduced rapidly when NaCl was added or the pH was increased in the environment. Furthermore, the antimicrobial efficacy of the optimized formulation was studied against Candida albicans, and more than 4 log reduction in viable cell after 5 min of contact was obtained.
authors.affiliation: Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu, People's Republic of China.
authors.forename: Shuai
authors.initials: S
authors.lastname: He
authors.forename: Biqing
authors.initials: B
authors.lastname: Wang
authors.forename: Honglin
authors.initials: H
authors.lastname: Chen
authors.forename: Chongli
authors.initials: C
authors.lastname: Tang
authors.forename: Yujun
authors.initials: Y
authors.lastname: Feng
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects / Q000254:growth & development; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D007455:Iodine / Q000737:chemistry / Q000494:pharmacology*; D000644:Quaternary Ammonium Compounds / Q000737:chemistry* / Q000494:pharmacology; D013501:Surface-Active Agents / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D000644:Quaternary Ammonium Compounds; D013501:Surface-Active Agents; D007455:Iodine