title: SKLB1028, a novel oral multikinase inhibitor of EGFR, FLT3 and Abl, displays exceptional activity in models of FLT3-driven AML and considerable potency in models of CML harboring Abl mutants.
authors.forename: Z-X
authors.initials: ZX
authors.lastname: Cao
authors.forename: J-J
authors.initials: JJ
authors.lastname: Liu
authors.forename: R-L
authors.initials: RL
authors.lastname: Zheng
authors.forename: J
authors.initials: J
authors.lastname: Yang
authors.forename: L
authors.initials: L
authors.lastname: Zhong
authors.forename: Y
authors.initials: Y
authors.lastname: Xu
authors.forename: L-J
authors.initials: LJ
authors.lastname: Wang
authors.forename: C-H
authors.initials: CH
authors.lastname: Zhang
authors.forename: B-L
authors.initials: BL
authors.lastname: Wang
authors.forename: S
authors.initials: S
authors.lastname: Ma
authors.forename: Z-R
authors.initials: ZR
authors.lastname: Wang
authors.forename: H-Z
authors.initials: HZ
authors.lastname: Xie
authors.forename: Y-Q
authors.initials: YQ
authors.lastname: Wei
authors.forename: S-Y
authors.initials: SY
authors.lastname: Yang
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D066246:ErbB Receptors / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D006801:Humans; D020128:Inhibitory Concentration 50; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy / Q000235:genetics*; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy / Q000235:genetics*; D009154:Mutation; D010766:Phosphorylation / Q000187:drug effects; D047428:Protein Kinase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D016315:Proto-Oncogene Proteins c-abl / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D011687:Purines / Q000494:pharmacology*; D023041:Xenograft Model Antitumor Assays; D051941:fms-Like Tyrosine Kinase 3 / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism
chemical_list: D047428:Protein Kinase Inhibitors; D011687:Purines; C576190:SKLB1028; D066246:ErbB Receptors; D051941:fms-Like Tyrosine Kinase 3; D016315:Proto-Oncogene Proteins c-abl