title: Five new amicoumacins isolated from a marine-derived bacterium Bacillus subtilis.
abstract: Four novel amicoumacins, namely lipoamicoumacins A-D (1-4), and one new bacilosarcin analog (5) were isolated from culture broth of a marine-derived bacterium Bacillus subtilis, together with six known amicoumacins. Their structures were elucidated on the basis of extensive spectroscopic (2D NNR, IR, CD and MS) analysis and in comparison with data in literature.
authors.affiliation: KAUST Global Collaborative Research, Division of Life Science, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
authors.forename: Yongxin
authors.initials: Y
authors.lastname: Li
authors.affiliation: KAUST Global Collaborative Research, Division of Life Science, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Xu
authors.affiliation: KAUST Global Collaborative Research, Division of Life Science, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
authors.forename: Lingli
authors.initials: L
authors.lastname: Liu
authors.affiliation: KAUST Global Collaborative Research, Division of Life Science, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
authors.forename: Zhuang
authors.initials: Z
authors.lastname: Han
authors.affiliation: KAUST Global Collaborative Research, Division of Life Science, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
authors.forename: Pok Yui
authors.initials: PY
authors.lastname: Lai
authors.affiliation: Advanced Nano-fabrication, Imaging & Characterization Core lab, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia.
authors.forename: Xiangrong
authors.initials: X
authors.lastname: Guo
authors.affiliation: Advanced Nano-fabrication, Imaging & Characterization Core lab, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia.
authors.forename: Xixiang
authors.initials: X
authors.lastname: Zhang
authors.affiliation: State Key Laboratory of Natural and Biomimetic Drugs, Peking University, Beijing 100191, China.
authors.forename: Wenhan
authors.identifier: 0000-0002-4978-4083
authors.initials: W
authors.lastname: Lin
authors.affiliation: KAUST Global Collaborative Research, Division of Life Science, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
authors.forename: Pei-Yuan
authors.initials: PY
authors.lastname: Qian
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D059001:Aquatic Organisms / Q000302:isolation & purification / Q000378:metabolism*; D001412:Bacillus subtilis / Q000302:isolation & purification / Q000378:metabolism*; D003374:Coumarins / Q000009:adverse effects / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D055808:Drug Discovery; D005285:Fermentation; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006367:HeLa Cells; D006801:Humans; D019156:Indian Ocean; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D020560:Proteobacteria / Q000187:drug effects; D013329:Structure-Activity Relationship; D008063:Thioctic Acid / Q000031:analogs & derivatives / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D003374:Coumarins; C573581:bacisarcin C; C031379:amicoumacin A; D008063:Thioctic Acid; C013091:lipoamide