title: Synthesis and reactivity of solid-supported organotrifluoroborates in Suzuki cross-coupling.
abstract: Solid-supported organotrifluoroborates were prepared in high yields by ion exchange with Amberlyst resins. The reactivity of solid supported aryltrifluoroborates was evaluated in Suzuki-Miyaura couplings with numerous aryl bromide partners. Electron-rich and -poor substituents were tolerated on both substrates, providing yields up to 90%. Examples of alkyl-, alkenyl-, alkynyl-, and heteroaryltrifluoborates were also successfully cross-coupled to aryl halides.
authors.affiliation: Neuroscience Medicinal Chemistry, Research & Development, Janssen Pharmaceutica, Turnhoutseweg 30, 2340 Beerse, Belgium.
authors.forename: Virginie
authors.initials: V
authors.lastname: Colombel
authors.forename: Marc
authors.initials: M
authors.lastname: Presset
authors.forename: Daniel
authors.initials: D
authors.lastname: Oehlrich
authors.forename: Frederik
authors.initials: F
authors.lastname: Rombouts
authors.forename: Gary A
authors.initials: GA
authors.lastname: Molander
mesh_terms: D001881:Borates / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D015394:Molecular Structure
chemical_list: D001881:Borates; D006846:Hydrocarbons, Halogenated