title: Diagnosis of interstitial cystitis/bladder pain syndrome in women with chronic pelvic pain: a prospective observational study.
abstract: OBJECTIVE
  This study assesses the prevalence of interstitial cystitis (IC)/bladder pain syndrome (BPS) in women with chronic pelvic pain (CPP).
  
  
  METHODS
  This was a prospective study of 150 women undergoing laparoscopy as investigation for CPP in an Endometriosis and Pelvic Pain unit. Preoperative questionnaires [demographic details, pelvic pain symptoms, the Pelvic Pain and Urgency/Frequency (PUF) and O'Leary-Sant (OLS) Symptom and Problem Index scores] were completed, and concurrent standardized cystoscopy with hydrodistention performed at laparoscopy. The primary outcome measures the proportion of IC in this group, defined by presence of glomerulations with CPP and urinary symptoms (urinary frequency, nocturia, urgency). The secondary outcome measures the proportion of BPS [defined by the European Society of the Study of Interstitial Cystitis (ESSIC)].
  
  
  RESULTS
  IC was diagnosed in 48/150 (32%) individuals, and 80/150 (53%) had BPS. There were no significant differences in symptomatology or questionnaire results between groups with and without IC. Women with BPS had higher PUF (17.2 vs 12.9, p < 0.001), OLS Symptom (8.2 vs 6.0, p = 0.001) and Problem (7.5 vs 4.2, p < 0.001) scores and more severe pain symptoms. Visually proven endometriosis was seen in 90/150 (60%), and 27/150 (18%) had both endometriosis and IC. Of the 80 women with BPS, 45/80 (60%) had endometriosis.
  
  
  CONCLUSIONS
  The prevalence of IC/BPS varies depending on the definition used. This study showed IC in 32% of women with CPP based on symptoms and presence of glomerulations. BPS as defined by ESSIC was diagnosed in 53%. History and questionnaires did not correlate with positive cystoscopic findings.
authors.affiliation: Royal Women's Hospital, 20 Flemington Road, Parkville, VIC 3052, Australia. claudiacheng@drclaudiacheng.com.au
authors.forename: Claudia
authors.initials: C
authors.lastname: Cheng
authors.forename: Anna
authors.initials: A
authors.lastname: Rosamilia
authors.forename: Martin
authors.initials: M
authors.lastname: Healey
mesh_terms: D000293:Adolescent; D000328:Adult; D059350:Chronic Pain / Q000453:epidemiology*; D015897:Comorbidity; D018856:Cystitis, Interstitial / Q000175:diagnosis* / Q000453:epidemiology* / Q000473:pathology; D003558:Cystoscopy; D004715:Endometriosis / Q000453:epidemiology; D005260:Female; D006801:Humans; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D017699:Pelvic Pain / Q000453:epidemiology*; D015995:Prevalence; D011446:Prospective Studies; D011795:Surveys and Questionnaires; D055815:Young Adult