title: Influence of parental consanguineous marriages on age at onset of bipolar disorder.
abstract: The present study was performed to investigate the association between parental consanguineous marriages and age at onset of bipolar disorder (BPD). A total of 195 BPD patients participated in the study. Kaplan-Meier analysis revealed that relationships between age at onset and cumulative proportion of patients have different patterns with respect to types of parental marriages. Among early onset cases, the age at onset was higher for offspring of consanguineous than unrelated marriages, whereas in late onset cases the age at onset was lower for offspring of consanguineous than unrelated marriages. However, there was no difference between consanguineous and unrelated marriages for intermediate age at onset.
authors.affiliation: Department of Biology, College of Sciences, Shiraz University, Shiraz 71454, Iran. saadat@susc.ac.ir
authors.forename: Mostafa
authors.initials: M
authors.lastname: Saadat
mesh_terms: D017668:Age of Onset; D001714:Bipolar Disorder / Q000453:epidemiology*; D003241:Consanguinity; D006801:Humans; D007492:Iran / Q000453:epidemiology; D053208:Kaplan-Meier Estimate; D008393:Marriage / Q000523:psychology*; D010290:Parents / Q000523:psychology*