title: Identification of citrinin as the defence metabolite of Penicillium corylophilum stressed with the antagonist fungus Beauveria bassiana.
abstract: Penicillium corylophilum isolated from mosquitoes was cultivated in liquid media leading to the first reported identification of citrinin (1a) as one metabolic component of this fungus. The produced amount of 1a indicated this compound as the most abundant secondary metabolite of this fungus. Stressing the culture of P. corylophilum with the presence of the antagonistic fungus Beauveria bassiana increased in 65% the production of 1a. Similar results were obtained with the presence of other fungi in the culture media, indicating that citrinin is the main defence metabolite of P. corylophilum. In agreement with this conclusion, citrinin showed a reasonable fungicidal activity against Colletotrichum gloeosporioides and B. bassiana.
authors.affiliation: Department of Chemistry, Military Institute of Engineering, Rio de Janeiro, Brazil.
authors.forename: Claudia Maria Campinha
authors.initials: CM
authors.lastname: Dos Santos
authors.forename: Gisela Lara
authors.initials: GL
authors.lastname: da Costa
authors.forename: José Daniel
authors.initials: JD
authors.lastname: Figueroa-Villar
mesh_terms: D000818:Animals; D052982:Beauveria / Q000187:drug effects; D001681:Biological Assay / Q000379:methods; D001938:Brazil; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D002953:Citrinin / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D020231:Colletotrichum / Q000187:drug effects; D009033:Culicidae / Q000382:microbiology*; D056265:Microbial Interactions / Q000502:physiology*; D015394:Molecular Structure; D010407:Penicillium / Q000737:chemistry*; D010572:Pest Control, Biological / Q000379:methods; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D002953:Citrinin