title: Weight loss is effective for symptomatic relief in obese subjects with knee osteoarthritis independently of joint damage severity assessed by high-field MRI and radiography.
abstract: OBJECTIVE
  With an increasing prevalence of older and obese citizens, the problems of knee osteoarthritis (KOA) will escalate. Weight loss is recommended for obese KOA patients and in a majority of cases this leads to symptomatic relief. We hypothesized that pre-treatment structural status of the knee joint, assessed by radiographs, 1.5 T magnetic resonance imaging (MRI) and knee-joint alignment, may influence the symptomatic changes following a significant weight reduction.
  
  
  METHODS
  Patients were recruited from a Department of Rheumatology. Eligibility criteria were age above 50 years, body mass index ≥ 30 kg/m(2), primary KOA diagnosed according to the American College of Rheumatology (ACR) criteria and having verified structural damage. Patients underwent a 16 weeks dietary programme with formula products and counselling. MRI and radiographs of the most symptomatic knee were obtained at baseline and assessed for structural damage using the Boston-Leeds Osteoarthritis of the Knee Score, minimum joint space width and Kellgren-Lawrence score. Imaging variables, muscle strength and degree of alignment, were examined as predictors of changes in Knee Osteoarthritis Outcome Score (KOOS) and Outcome Measures in Rheumatoid Arthritis Clinical Trials (OMERACT) - Osteoarthritis Research Society International (OARSI) Responder Criterion.
  
  
  RESULTS
  Structural damage at baseline assessed by imaging, muscle strength or knee-joint alignment showed no statistically significant association to changes in KOOS pain and function in daily living (r ≤ 0.13; P>0.05) or the OMERACT-OARSI Responder Criterion (OR 0.48-1.68; P-values ≥ 0.13).
  
  
  CONCLUSIONS
  Presence of joint damage did not preclude symptomatic relief following a clinically relevant weight loss in older obese patients with KOA. Neither muscle strength nor knee-joint alignment was associated with the degree of symptomatic relief.
authors.affiliation: The Parker Institute, Copenhagen University Hospital, Frederiksberg, Denmark. drhg@dadlnet.dk
authors.forename: H
authors.initials: H
authors.lastname: Gudbergsen
authors.forename: M
authors.initials: M
authors.lastname: Boesen
authors.forename: L S
authors.initials: LS
authors.lastname: Lohmander
authors.forename: R
authors.initials: R
authors.lastname: Christensen
authors.forename: M
authors.initials: M
authors.lastname: Henriksen
authors.forename: E M
authors.initials: EM
authors.lastname: Bartels
authors.forename: P
authors.initials: P
authors.lastname: Christensen
authors.forename: L
authors.initials: L
authors.lastname: Rindel
authors.forename: J
authors.initials: J
authors.lastname: Aaboe
authors.forename: B
authors.initials: B
authors.lastname: Danneskiold-Samsøe
authors.forename: B F
authors.initials: BF
authors.lastname: Riecke
authors.forename: H
authors.initials: H
authors.lastname: Bliddal
mesh_terms: D000368:Aged; D000886:Anthropometry / Q000379:methods; D015992:Body Mass Index; D005260:Female; D006801:Humans; D007719:Knee Joint / Q000000981:diagnostic imaging / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength / Q000502:physiology; D009765:Obesity / Q000150:complications* / Q000178:diet therapy*; D020370:Osteoarthritis, Knee / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D011859:Radiography; D012720:Severity of Illness Index; D016896:Treatment Outcome; D015431:Weight Loss