title: Synthesis of imidazo[4,5-b]pyridines and imidazo[4,5-b]pyrazines by palladium catalyzed amidation of 2-chloro-3-amino-heterocycles.
abstract: A facile synthesis of imidazo[4,5-b]pyridines and -pyrazines is described using a Pd-catalyzed amide coupling reaction. This reaction provides quick access to products with substitution at N1 and C2. A model system relevant to the natural product pentosidine has been demonstrated, as well as the total synthesis of the mutagen 1-Me-5-PhIP.
authors.affiliation: Department of Chemistry, 1-014 Center for Science and Technology, Syracuse University, Syracuse, New York 13244, USA.
authors.forename: Adam J
authors.initials: AJ
authors.lastname: Rosenberg
authors.forename: Jinbo
authors.initials: J
authors.lastname: Zhao
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Clark