title: Vaspin--a link of obesity and psoriasis?
abstract: Psoriasis is an inflammatory skin disease often associated with obesity. The anti-inflammatory adipokine vaspin, a suggested serine proteinase inhibitor of the serpin family, is discussed as a new link between inflammation and obesity. Here, we demonstrate that - different from healthy controls - vaspin serum levels in patients with psoriasis were body mass index independent. Moreover, we could identify keratinocytes as the major source of vaspin in skin. Vaspin expression in lesional psoriatic skin was reduced compared with uninvolved skin as shown by immunohistochemistry and RT-PCR. In aggregate, we report on the cellular source of vaspin in skin and its expression in psoriasis.
authors.forename: Anja
authors.initials: A
authors.lastname: Saalbach
authors.forename: Katharina
authors.initials: K
authors.lastname: Vester
authors.forename: Kathrin
authors.initials: K
authors.lastname: Rall
authors.forename: Jenny
authors.initials: J
authors.lastname: Tremel
authors.forename: Ulf
authors.initials: U
authors.lastname: Anderegg
authors.forename: Annette G
authors.initials: AG
authors.lastname: Beck-Sickinger
authors.forename: Matthias
authors.initials: M
authors.lastname: Blüher
authors.forename: Jan C
authors.initials: JC
authors.lastname: Simon
mesh_terms: D001483:Base Sequence; D015992:Body Mass Index; D016022:Case-Control Studies; D015870:Gene Expression; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood / Q000378:metabolism; D015603:Keratinocytes / Q000378:metabolism; D009765:Obesity / Q000097:blood / Q000150:complications* / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D011565:Psoriasis / Q000097:blood / Q000150:complications* / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D015843:Serpins / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D012867:Skin / Q000378:metabolism / Q000473:pathology
chemical_list: D018836:Inflammation Mediators; D012333:RNA, Messenger; C507339:SERPINA12 protein, human; D015843:Serpins