title: Outcomes and predictors of failure of trocar-guided vaginal mesh surgery for pelvic organ prolapse.
abstract: OBJECTIVE
  The objective of the study was to compare the 1 year conventional and composite outcomes of trocar-guided vaginal mesh surgery and the identification of the predictors of failure.
  
  
  METHODS
  This was a prospective observational cohort study. Failure outcome definitions were as follows: I, prolapse stage II or greater in mesh treated compartments; II, overall prolapse stage II or greater; III, composite outcome of overall prolapse greater than the hymen and the presence of bulge symptoms or repeat surgery. We used logistic regression to identify predictors of failure.
  
  
  RESULTS
  The results of the study were 1 year follow-up of 433 patients. Treated compartment failure (I) was 15% (95% confidence interval [CI], 12-19). Overall prolapse failure (II) was 41% (95% CI, 36-45). Composite failure (III) was 9% (95% CI, 7-13). Predictor of failure in all outcomes was the combined anterior/posterior mesh with the uterus in situ.
  
  
  CONCLUSIONS
  Outcome of prolapse surgery depends on outcome definition. The mesh treated compartment failure outcome (I) and the composite failure outcome (III) appeared not to be statistically different. Consistent factor for failure in all outcomes was the combined anterior/posterior mesh insertion with the uterus in situ.
authors.affiliation: Department of Obstetrics and Gynecology, Reinier de Graaf Group, Delft, The Netherlands. fredmilani@me.com
authors.forename: Alfredo L
authors.initials: AL
authors.lastname: Milani
authors.forename: Mariella I J
authors.initials: MI
authors.lastname: Withagen
authors.forename: Mark E
authors.initials: ME
authors.lastname: Vierhout
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D013509:Gynecologic Surgical Procedures / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D056887:Pelvic Organ Prolapse / Q000601:surgery*; D011446:Prospective Studies; D012307:Risk Factors; D013526:Surgical Mesh; D011795:Surveys and Questionnaires; D017211:Treatment Failure; D014621:Vagina / Q000601:surgery*; D055815:Young Adult