title: Imaging measures predict progression in progressive supranuclear palsy.
abstract: OBJECTIVE
  The aim of this work was to determine whether the progressive supranuclear palsy rating scale, a measure of disease severity, is associated with neuroanatomical changes in progressive supranuclear palsy.
  
  
  METHODS
  We recruited 22 subjects with probable progressive supranuclear palsy who completed the progressive supranuclear palsy rating scale at 2 time points. All subjects had magnetic resonance imaging and diffusion tensor imaging. Associations were assessed between whole brain volume, ventricular volume, midbrain area and superior cerebellar peduncle fractional anisotropy, and baseline/change of the progressive supranuclear palsy rating scale.
  
  
  RESULTS
  Superior cerebellar peduncle fractional anisotropy correlated with the total score and gait/midline subscore of the progressive supranuclear palsy rating scale. Whole brain volume, midbrain area, and disease duration predicted subsequent change over time in the gait/midline subscore of the progressive supranuclear palsy rating scale.
  
  
  CONCLUSIONS
  Imaging measures could be useful to help predict clinical progression in subjects with progressive supranuclear palsy.
authors.affiliation: Department of Radiology, Mayo Clinic, Rochester, Minnesota 55905, USA. whitwell.jennifer@mayo.edu
authors.forename: Jennifer L
authors.initials: JL
authors.lastname: Whitwell
authors.forename: Jia
authors.initials: J
authors.lastname: Xu
authors.forename: Jay
authors.initials: J
authors.lastname: Mandrekar
authors.forename: Jeffrey L
authors.initials: JL
authors.lastname: Gunter
authors.forename: Clifford R
authors.initials: CR
authors.lastname: Jack
authors.forename: Keith A
authors.initials: KA
authors.lastname: Josephs
mesh_terms: D000368:Aged; D016880:Anisotropy; D001931:Brain Mapping; D056324:Diffusion Tensor Imaging / Q000379:methods; D018450:Disease Progression; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D013494:Supranuclear Palsy, Progressive / Q000473:pathology*