title: Synthesis and characterization of pH-responsive and folated nanoparticles based on self-assembled brush-like PLGA/PEG/AEMA copolymer with targeted cancer therapy properties: A comprehensive kinetic study.
abstract: In this study, a novel nanocarrier was synthesized based on methacrylated poly(lactic-co-glycolic acid) (mPLGA) as a lipophilic domain, acrylated methoxy poly(ethylene glycol) (aMPEG) as hydrophilic part and N-2-[(tert-butoxycarbonyl)amino] ethyl methacrylamide (Boc-AEMA) as pH-responsive segment. Radical polymerization of the above-mentioned three modified monomers produces amphiphilic brush-like copolymer. The protecting amine group (Boc) was selectively deprotected and the latter targeted copolymer was produced through the reaction of this copolymer with activated folic acid. Nanoprecipitation method was used to prepare quercetin-loaded nanoparticles. Dynamic light scattering (DLS) analysis showed that the produced nanoparticles had nanometric size (<100nm) and low polydispersity in size at different pHs. Higuchi and Korsmeyer-Peppas models were applied to evaluate release mechanisms and kinetics. Based on in-vitro degradation study, we found that the brush-like copolymer underwent a rapid weight loss in acidic pH.
authors.affiliation: Polymer Chemistry Department, School of Science, University of Tehran, PO Box 14155-6455, Tehran, Iran. Khoee@Khayam.ut.ac.ir
authors.forename: Sepideh
authors.initials: S
authors.lastname: Khoee
authors.forename: Reza
authors.initials: R
authors.lastname: Rahmatolahzadeh
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology; D004337:Drug Carriers; D016503:Drug Delivery Systems; D005021:Ethylamines / Q000737:chemistry*; D005492:Folic Acid / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D007700:Kinetics; D008689:Methacrylates / Q000737:chemistry*; D008823:Micelles; D053758:Nanoparticles; D011092:Polyethylene Glycols / Q000737:chemistry*; D011098:Polyglactin 910 / Q000737:chemistry*; D011108:Polymers / Q000138:chemical synthesis* / Q000378:metabolism*; D011794:Quercetin / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D000975:Antioxidants; D004337:Drug Carriers; D005021:Ethylamines; D008689:Methacrylates; D008823:Micelles; D011108:Polymers; C514459:aminoethyl methacrylate; C102418:poly(lactic-glycolic acid)-poly(ethyleneglycol) copolymer; D011098:Polyglactin 910; D011092:Polyethylene Glycols; D005492:Folic Acid; D011794:Quercetin