title: The prevalence of metabolic syndrome in clomiphene citrate resistant polycystic ovary syndrome.
abstract: OBJECTIVE
  To investigate the prevalence of metabolic syndrome in clomiphene citrate (CC) resistant polycystic ovary syndrome (PCOS) patients.
  
  
  METHODS
  58 CC resistant PCOS patients, 52 CC responders, 53 fertile PCOS and 53 age and body mass index-matched normoandrogenic ovulatory fertile women were evaluated for metabolic syndrome.
  
  
  RESULTS
  Metabolic syndrome prevalence was 41.4% in CC resistants, in 23.1% of CC responders, in 11.3% of PCOS fertiles and 0% of controls (p < 0.0001). Waist circumference (WC) > 88 cm was 44.8%, systolic blood pressure (BP) ≥ 130 mmHg and diastolic BP ≥85 mmHg were 27.6%, TG (triglyceride) ≥150 mg/dL was 36.2%, HDL(high density lipoprotein) < 50 mg/dL was 63.8%, fasting glucose levels ≥ 100 mg/dL was 20.7% in CC resistant PCOS women. There were positive associations between CC resistance and WC >88 cm, BP ≥ 130 ≥ 85 mmHg, TG ≥ 150 mg/dL, HDL < 50 mg/dL, fasting glucose ≥ 100 mg/dL, and presence of metabolic syndrome (p < 0.05, for all). Moreover, WC > 88 cm, and HDL < 50 mg/dL were independent variables that were associated by CC resistance by multivariate regression analysis.
  
  
  CONCLUSIONS
  CC resistant PCOS patients have high prevalence of metabolic syndrome. These women have an increased risk of future cardiovascular disease.
authors.affiliation: Department of Obstetrics and Gynecology, Harran University Faculty of Medicine, Sanliurfa Turkey. fverit@gmail.com
authors.forename: Fatma Ferda
authors.initials: FF
authors.lastname: Verit
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002996:Clomiphene / Q000627:therapeutic use*; D004351:Drug Resistance; D005260:Female; D005300:Fertility Agents, Female / Q000627:therapeutic use*; D006801:Humans; D007247:Infertility, Female / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology; D016015:Logistic Models; D024821:Metabolic Syndrome / Q000150:complications / Q000453:epidemiology*; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology*; D011247:Pregnancy; D015995:Prevalence; D014421:Turkey / Q000453:epidemiology; D055815:Young Adult
chemical_list: D005300:Fertility Agents, Female; D002996:Clomiphene