title: Evaluation of clear corneal wound dynamics with contrast-enhanced spectral-domain optical coherence tomography.
abstract: OBJECTIVE
  To evaluate wound morphology and integrity using contrast-enhanced spectral-domain optical coherence tomography (SD-OCT).
  
  
  METHODS
  Eighteen patients (18 eyes) undergoing unilateral routine cataract surgery were enrolled. SD-OCT imaging of the corneal wound was performed immediately following cataract surgery and on postoperative day 1. A topical contrast agent, prednisolone acetate 1%, was used to help evaluate wound integrity. OCT features of the corneal incision and changes in wound interface reflectivity after administration of topical prednisolone acetate 1% were analyzed. Main outcome measures were quantitative and qualitative description of wound morphology and contrast enhancement of the wound interface.
  
  
  RESULTS
  Internal wound gape was found in 89% of eyes. Gape area decreased by 43% from days 0 to 1 (462 vs 273 μm(2); P < .01). Contrast enhancement at the wound interface was seen in 56% of eyes on day 0 compared to 17% on day 1 following application of prednisolone acetate 1% (P < .05). Decreased intraocular pressure correlated with increased contrast enhancement (P < .05).
  
  
  CONCLUSIONS
  Wound morphology evolves during the early postoperative period. Wound gape and ingress of a topical contrast agent decrease during the first 24 hours following surgery. Contrast enhancement at the wound interface increases as the intraocular pressure decreases.
authors.affiliation: Department of Ophthalmology, Duke Eye Center, Durham, NC 27710, USA.
authors.forename: Preeya K
authors.initials: PK
authors.lastname: Gupta
authors.forename: Justis P
authors.initials: JP
authors.lastname: Ehlers
authors.forename: Terry
authors.initials: T
authors.lastname: Kim
mesh_terms: D003287:Contrast Media / Q000008:administration & dosage; D003315:Cornea / Q000503:physiopathology* / Q000601:surgery*; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D007429:Intraocular Pressure; D019654:Lens Implantation, Intraocular; D008297:Male; D018918:Phacoemulsification / Q000379:methods*; D011239:Prednisolone / Q000008:administration & dosage / Q000031:analogs & derivatives; D013529:Surgical Wound Dehiscence / Q000503:physiopathology*; D041623:Tomography, Optical Coherence; D014945:Wound Healing / Q000502:physiology*
chemical_list: D003287:Contrast Media; D005938:Glucocorticoids; C009935:prednisolone acetate; D011239:Prednisolone