title: A simple method for the determination of peak distribution in comprehensive two-dimensional liquid chromatography.
abstract: In LC × LC the peak capacity (2D)n and the orthogonality O are often used as parameters of resolving power. Unfortunately, these parameters are not easily accessible from chromatograms. In this work we will present a novel method, based on the description as vectors of experimentally easily accessible data. This approach makes it possible to calculate separation space (peak distribution) in parallelograms and other more complex geometric patterns by describing a two dimensional area by vectors. The calculated separation space allows a comparison between several column combinations and is a useful tool in optimization of LC × LC analysis.
authors.affiliation: University of Wuppertal, Institute for Pure and Applied Mass Spectrometry (iPAMS), Gauss-Str. 20, 42119 Wuppertal, Germany.
authors.forename: Roman
authors.initials: R
authors.lastname: Dück
authors.forename: Hannah
authors.initials: H
authors.lastname: Sonderfeld
authors.forename: Oliver J
authors.initials: OJ
authors.lastname: Schmitz
mesh_terms: D000465:Algorithms; D029971:Angelica sinensis; D002853:Chromatography, Liquid / Q000379:methods*; D004365:Drugs, Chinese Herbal / Q000032:analysis / Q000737:chemistry; D008956:Models, Chemical
chemical_list: D004365:Drugs, Chinese Herbal; C044613:angelicae sinensis extract