title: Blood glucose measurements in critically ill patients.
abstract: Studies on tight glycemic control by intensive insulin therapy abruptly changed the climate of limited interest in the problem of hyperglycemia in critically ill patients and reopened the discussion on accuracy and reliability of glucose sensor devices. This article describes important components of blood glucose measurements and their interferences with the focus on the intensive care unit setting. Typical methodologies, organized from analytical accuracy to clinical accuracy, to assess imprecision and bias of a glucose sensor are also discussed. Finally, a list of recommendations and requirements to be considered when evaluating (time-discrete) glucose sensor devices is given.
authors.affiliation: Department of Intensive Care Medicine, University Hospitals Leuven, Katholieke Universiteit Leuven, Leuven, Belgium.
authors.forename: Tom
authors.initials: T
authors.lastname: Van Herpe
authors.forename: Dieter
authors.initials: D
authors.lastname: Mesotten
mesh_terms: D015374:Biosensing Techniques / Q000295:instrumentation / Q000592:standards; D001774:Blood Chemical Analysis / Q000295:instrumentation / Q000379:methods* / Q000592:standards; D001786:Blood Glucose / Q000032:analysis*; D003422:Critical Care / Q000379:methods*; D016638:Critical Illness / Q000628:therapy*; D006801:Humans; D007362:Intensive Care Units; D008991:Monitoring, Physiologic / Q000295:instrumentation / Q000379:methods / Q000592:standards; D014894:Weights and Measures
chemical_list: D001786:Blood Glucose