title: [Marked response to oral administration of UFT and leucovorin for liver metastases from colon cancer in an elderly patient].
abstract: A83 -year-old man was admitted to our hospital for the treatment of advanced ascending colon cancer with liver metastases. He had initially undergone an ileocecal resection for ascending colon cancer. Subsequently, we started oral administration of UFT/LV(UFT 400mg/day, LV 75 mg/day, and 4 weeks of therapy followed by a week suspension of treatment). After 3 courses, his tumors responded well to treatment, and CT showed marked regression of liver metastases. After 10 courses, liver metastases had almost disappeared. Two years passed without any adverse events since UFT/LV therapy was started. These findings suggest that UFT/LV therapy is very safe and effective for elderly patients with unresectable colorectal cancer.
authors.affiliation: Dept. of Gastroenterological Surgery, Kochi Health Sciences Center, Japan.
authors.forename: Fuminori
authors.initials: F
authors.lastname: Teraishi
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Ozaki
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Shibuya
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Shima
authors.forename: Toshio
authors.initials: T
authors.lastname: Nakamura
authors.forename: Madoka
authors.initials: M
authors.lastname: Hamada
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Fukui
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Nishioka
authors.forename: Tadashi
authors.initials: T
authors.lastname: Horimi
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Uchida
mesh_terms: D000284:Administration, Oral; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D005641:Tegafur / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D014498:Uracil / Q000627:therapeutic use
chemical_list: D005641:Tegafur; D014498:Uracil; D002955:Leucovorin