title: Upregulation of MHC class I expression following dengue virus infection: the mechanism at the promoter level.
abstract: Unlike many other viruses that downregulate MHC class I expression on infected cell membranes, flaviviruses were reported to upregulate the MHC class I expression. Dengue virus was shown to induce HLA class I expression; however, the precise transcriptional mechanism that is used by the virus remains unclear. This article assessed the findings of a recently published report describing the mechanism used by dengue virus to induce HLA-A2 expression and characterizing the transcription factors that are involved. The study showed that p50/p65 and p65/65 NF-κB dimers bind to the class I regulatory complex within the HLA-A2 promoter. This finding and its significance for the design of possible antiviral therapeutic agents are discussed in this article.
authors.affiliation: The Shraga Segal Department of Microbiology and Immunology and the National Institute for Biotechnology in the Negev, Ben Gurion University of the Negev, Beer Sheva, Israel.
authors.forename: Rami
authors.initials: R
authors.lastname: Yossef
authors.forename: Benyamin
authors.initials: B
authors.lastname: Rosental
authors.forename: Michael Y
authors.initials: MY
authors.lastname: Appel
authors.forename: Oren
authors.initials: O
authors.lastname: Hershkovitz
authors.forename: Angel
authors.initials: A
authors.lastname: Porgador