title: Atypical diffusion-restricted lesion in 5-Fluorouracil encephalopathy.
abstract: Central nervous system toxicity of 5-FU could show various manifestations, such as decreased alertness, disorientation, and agitation. It is generally accepted that lesions of 5-FU encephalopathy are mainly in the deep cerebral white matter and corpus callosum on MR imaging. Here we describe a case of 5-FU encephalopathy in gastric cancer with an atypical reversible diffusion-restricted lesion on MR imaging, showing bilateral basal ganglia, thalami, and parasagittal frontal cortex involvement on diffusion and T2-weighted imaging.
authors.affiliation: Department of Neurology, Seoul Metropolitan Government-Seoul National University Boramae Medical Center, Seoul, Republic of Korea.
authors.forename: W-W
authors.initials: WW
authors.lastname: Lee
authors.forename: J-S
authors.initials: JS
authors.lastname: Kim
authors.forename: K R
authors.initials: KR
authors.lastname: Son
authors.forename: H-M
authors.initials: HM
authors.lastname: Kwon
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects; D001921:Brain / Q000187:drug effects* / Q000473:pathology*; D001927:Brain Diseases / Q000139:chemically induced* / Q000473:pathology*; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D005472:Fluorouracil / Q000009:adverse effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D008297:Male; D008875:Middle Aged
chemical_list: D000964:Antimetabolites, Antineoplastic; D007166:Immunosuppressive Agents; D005472:Fluorouracil