title: Systems pharmacology of complex diseases.
abstract: Systems pharmacology approaches can be used to identify and predict drug-induced adverse events. Disease-centered networks within the human interactome allow us to predict which drugs may produce a similar pathophysiology. Such predictions can be tested in animal models.
authors.affiliation: Pharmacology and Systems Therapeutics and Systems Biology Center, Mount Sinai School of Medicine, New York, New York 10029, USA.
authors.forename: Jens
authors.initials: J
authors.lastname: Hansen
authors.forename: Shan
authors.initials: S
authors.lastname: Zhao
authors.forename: Ravi
authors.initials: R
authors.lastname: Iyengar
mesh_terms: D000818:Animals; D064420:Drug-Related Side Effects and Adverse Reactions / Q000235:genetics / Q000378:metabolism; D053263:Gene Regulatory Networks / Q000235:genetics*; D006801:Humans; D004364:Pharmaceutical Preparations / Q000378:metabolism; D057285:Precision Medicine / Q000379:methods / Q000639:trends; D049490:Systems Biology / Q000379:methods* / Q000639:trends
chemical_list: D004364:Pharmaceutical Preparations