title: [High-fat diets and body composition over two generations. An experimental study].
abstract: OBJECTIVE
  Despite recent findings reported on the nutritional factors that induce epigenetic changes, little information is available at early ages. This study analyzed in an experimental model, over two generations, potential changes in body composition and potential expression of epigenetic changes as the result of the intake of isoenergetic diets with different fat levels.
  
  
  METHODS
  At weaning, Wistar female rats were divided into two groups that were fed either a control diet (fat=7% w/w) or a high-fat diet (15% w/w). Rats were mated at 70 days (M(1)) and their pups (P(1)) were the first generation; P(1) rats were mated at 70 days (M(2)) and their pups (P(2)) represented the second generation. At weaning, mothers and pups (M(1), M(2) and P(1), P(2)) were measured body weight (W) and composition (% body fat, %BF), and total skeleton bone mineral content (BMC), expressed as %BMC, using chemical and DXA methods respectively.
  
  
  RESULTS
  At weaning, high-fat diet groups M(2) and P(2) showed significant increases in W and %BF (p<0.05); increased %BF values were already found in the M(1) and P(1) groups (p<0.001). By contrast, %BMC significantly decreased in M(2) and P(2) rats (p<0.001).
  
  
  CONCLUSIONS
  This study demonstrates the need to review certain eating habits to avoid perpetuation of unhealthy patterns generation after generation.
authors.affiliation: Cátedra de Bioquímica General y Bucal, Facultad de Odontología, Universidad de Buenos Aires, Buenos Aires, Argentina.
authors.forename: Cristina
authors.initials: C
authors.lastname: Suarez
authors.forename: Andrea
authors.initials: A
authors.lastname: Ferreira Monteiro
authors.forename: Elisa
authors.initials: E
authors.lastname: Macri
authors.forename: Ana
authors.initials: A
authors.lastname: Chiarenza
authors.forename: Susana
authors.initials: S
authors.lastname: Zeni
authors.forename: Patricia
authors.initials: P
authors.lastname: Rodríguez
authors.forename: Patricia
authors.initials: P
authors.lastname: Boyer
authors.forename: Silvia
authors.initials: S
authors.lastname: Friedman
mesh_terms: D050154:Adiposity / Q000187:drug effects / Q000235:genetics; D000818:Animals; D001823:Body Composition / Q000187:drug effects* / Q000235:genetics; D001835:Body Weight / Q000187:drug effects / Q000235:genetics; D015519:Bone Density / Q000187:drug effects / Q000235:genetics; D004041:Dietary Fats / Q000494:pharmacology* / Q000633:toxicity; D002149:Energy Intake; D005260:Female; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014886:Weaning
chemical_list: D004041:Dietary Fats