title: RDS--CPAP or surfactant or both.
abstract: There is mounting evidence that early continuous positive airway pressure (CPAP) from birth is feasible and safe even in very preterm infants. However, many infants will develop respiratory distress syndrome (RDS) and require surfactant treatment. Combining a non-invasive ventilation approach with a strategy for surfactant administration is important, but questions remain about the optimal timing, mode of delivery and the value of predictive tests for surfactant deficiency.
  
  
  CONCLUSIONS
  Early CPAP in very preterm infants is as safe as routine intubation in the delivery room. However, a strategy for surfactant administration should be part of a non-invasive ventilation approach for those infants at risk of developing significant RDS.
authors.affiliation: Department of Neonatology, Karolinska University Hospital and Karolinska Institutet, Stockholm, Sweden. kajsa.bohlin@ki.se
authors.forename: Kajsa
authors.initials: K
authors.lastname: Bohlin
mesh_terms: D003131:Combined Modality Therapy; D045422:Continuous Positive Airway Pressure / Q000379:methods*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D007385:Intermittent Positive-Pressure Ventilation / Q000009:adverse effects; D011663:Pulmonary Surfactants / Q000627:therapeutic use*; D012127:Respiratory Distress Syndrome, Newborn / Q000517:prevention & control / Q000628:therapy*
chemical_list: D011663:Pulmonary Surfactants