title: [Screening of differentially expressed microRNAs in bone marrow-derived mesenchymal stem cells during osteoporosis and their function in stem cell differentiation].
abstract: To screen differentially expressed microRNAs in bone marrow-derived mesenchymal stem cells (BMMSCs) during osteoporosis and their function in stem cell differentiation.
  
  
  
  The osteoporosis model was induced by ovariectomy in mice.The differentially expressed microRNAs in BMMSCs during osteoporosis were screened with microRNA microarray chip and their expressions during osteogenesis and adipogenesis were detected by RT-PCR.
  
  
  
  Ten differentially expressed microRNAs were detected in BMMSC during osteoporosis. The expression of 5 specific microRNAs altered significantly during osteogenic differentiation and 3 microRNAs altered during adipogenic differentiation.
  
  
  
  A serials of differentially expressed microRNAs may be involved in functional defects of BMMSC during osteoporosis.
authors.affiliation: Department of Oral Histology & Pathology, School of Stomatology, Research and Development Center for Tissue Engineering, Fourth Military Medical University, Xi'an 710032, China.
authors.forename: Li
authors.initials: L
authors.lastname: Liao
authors.forename: Xaio-hong
authors.initials: XH
authors.lastname: Yang
authors.forename: Yan
authors.initials: Y
authors.lastname: Jin
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology / Q000378:metabolism*; D002454:Cell Differentiation; D004195:Disease Models, Animal; D005260:Female; D020869:Gene Expression Profiling; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D035683:MicroRNAs / Q000378:metabolism*; D046208:Microchip Analytical Procedures; D010024:Osteoporosis / Q000378:metabolism* / Q000503:physiopathology
chemical_list: D035683:MicroRNAs