title: Effect of protein concentrations of bovine serum albumin and γ-globulin on the frictional response of a cobalt-chromium femoral head.
abstract: The study aims to identify the concentration-dependent role of bovine serum albumin (BSA) and γ-globulin in the lubricating ability of a cobalt-chromium femoral head. The frictional coefficients of the cobalt-chromium femoral head decreased with increasing BSA concentrations from 10 to 40 mg/ml and showed statistical differences between any of the BSA concentration groups, except between the 30 and 40 mg/ml concentration groups. In γ-globulin, the frictional coefficients significantly decreased at concentrations of 2.5 and 5.0 mg/ml as compared with the PBS control group, but significant increases were observed at 7.5 and 12.5 mg/ml. These results suggest that the friction of the cobalt-chromium femoral head is dependent on the concentration of both BSA and γ-globulin. However, there is a maximum concentration for BSA to act as an effective boundary lubricant, while the lubricating ability of γ-globulin is most effective in the physiological concentration range within human synovial fluid.
authors.affiliation: School of Mechanical Engineering & Institute for Skeletal Aging, Pusan National University, Busan, Republic of Korea.
authors.forename: Cong-Truyen
authors.initials: CT
authors.lastname: Duong
authors.forename: Jae-Hoon
authors.initials: JH
authors.lastname: Lee
authors.forename: Younho
authors.initials: Y
authors.lastname: Cho
authors.forename: Ju-Suk
authors.initials: JS
authors.lastname: Nam
authors.forename: Hyong-Nyun
authors.initials: HN
authors.lastname: Kim
authors.forename: Sang-Soo
authors.initials: SS
authors.lastname: Lee
authors.forename: Seonghun
authors.initials: S
authors.lastname: Park
mesh_terms: D000818:Animals; D002417:Cattle; D002858:Chromium Alloys / Q000737:chemistry*; D017276:Friction / Q000187:drug effects*; D006622:Hip Prosthesis; D006801:Humans; D008962:Models, Theoretical; D009994:Osmolar Concentration; D011506:Proteins / Q000737:chemistry / Q000494:pharmacology; D012710:Serum Albumin, Bovine / Q000737:chemistry / Q000494:pharmacology*; D013499:Surface Properties / Q000187:drug effects; D013582:Synovial Fluid / Q000737:chemistry / Q000502:physiology; D005719:gamma-Globulins / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D002858:Chromium Alloys; D011506:Proteins; D005719:gamma-Globulins; D012710:Serum Albumin, Bovine