title: Community-associated methicillin-resistant Staphylococcus aureus endocarditis 'down under': case series and literature review.
abstract: Infective endocarditis is a common complication of Staphylococcus aureus bacteraemia, but literature reports of community-associated methicillin-resistant S. aureus (CA-MRSA) endocarditis are relatively uncommon and mostly comprise intravenous drug users (IVDUs) with the USA300 strain. We report 5 cases of CA-MRSA endocarditis in previously healthy young Australian adults, 4 in IVDUs. Morbidity was high with frequent septic emboli; 3 patients required cardiac surgery and 1 patient died. Typing revealed the 2 most common Australian strains, the Panton-Valentine leukocidin (PVL)-positive ST93 (Queensland) strain and the PVL-negative ST1 (WA-MRSA-1) strain.
authors.affiliation: Infection Management Service, Princess Alexandra Hospital, Brisbane, Queensland, Australia.
authors.forename: Nicola J
authors.initials: NJ
authors.lastname: Townell
authors.forename: Wendy J
authors.initials: WJ
authors.lastname: Munckhof
authors.forename: Graeme
authors.initials: G
authors.lastname: Nimmo
authors.forename: Aiveen
authors.initials: A
authors.lastname: Bannan
authors.forename: Anthony
authors.initials: A
authors.lastname: Holley
authors.forename: Abhay
authors.initials: A
authors.lastname: Daniel
authors.forename: Cameron
authors.initials: C
authors.lastname: Bennett
authors.forename: Christopher
authors.initials: C
authors.lastname: Coulter
authors.forename: David F M
authors.initials: DF
authors.lastname: Looke
mesh_terms: D000328:Adult; D017714:Community-Acquired Infections / Q000453:epidemiology* / Q000382:microbiology* / Q000401:mortality / Q000473:pathology; D004696:Endocarditis / Q000453:epidemiology* / Q000382:microbiology* / Q000401:mortality / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D058889:Molecular Typing; D011793:Queensland / Q000453:epidemiology; D013203:Staphylococcal Infections / Q000453:epidemiology* / Q000382:microbiology* / Q000401:mortality / Q000473:pathology; D015819:Substance Abuse, Intravenous / Q000150:complications; D016019:Survival Analysis; D016896:Treatment Outcome; D055815:Young Adult