title: Grewialin and optivanin new constituents from the stem bark of Grewia optiva Drummond ex Burret (Tiliaceae).
abstract: Studies on the chemical constituents from the stem bark of Grewia optiva have led to the isolation of two new compounds, grewialin (1) and optivanin (2), along with three known constituents which were hitherto unreported from this species. The structures of the new constituents have been elucidated by spectral studies including 1D and 2D NMR experiments (HSQC, HMBC, COSY, NOESY and J-resolved) as well as HR EI-MS spectroscopic data analysis, as 2S*-(3-hydroxy-4-methoxyphenyl)-3R*-methyl-2H-[1,4]-dioxin [2,3]-chromen-7(3H)-one (1); a coumarinolignan and 3-hydroxy-1-(3-hydroxy-4-methoxyphenyl) propan-1-one (2). The known compounds were identified as β-sitosterol, stigmasterol and lupeol by comparing their spectral data with those reported in the literature.
authors.affiliation: Centre for Phytomedicine and Medicinal Organic Chemistry, Institute of Chemical Sciences, University of Peshawar, Peshawar-25120, Pakistan. drghiasuddin@hotmail.com
authors.forename: Ghias
authors.initials: G
authors.lastname: Uddin
authors.forename: Wali
authors.initials: W
authors.lastname: Ullah
authors.forename: Bina Shaheen
authors.initials: BS
authors.lastname: Siddiqui
authors.forename: Syed Qaisar
authors.initials: SQ
authors.lastname: Shah
mesh_terms: D032382:Grewia / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D053978:Pentacyclic Triterpenes / Q000737:chemistry; D012855:Sitosterols / Q000737:chemistry; D013265:Stigmasterol / Q000737:chemistry; D000094042:Lupanes
chemical_list: D053978:Pentacyclic Triterpenes; D012855:Sitosterols; D013265:Stigmasterol; C025473:gamma-sitosterol; C010480:lupeol; D000094042:Lupanes