title: Design and synthesis of a "click" high-mannose oligosaccharide mimic emulating Man8 binding affinity towards Con A.
abstract: A dendritic "click" mannooligomer mimicking the high-mannose oligosaccharide Man(8) has been designed by replacing some of the inner mannopyranosyl subunits with triazole moieties; evaluation of its binding affinity towards the mannose-specific lectin concanavalin A revealed striking similarities between the "click" mimic and the natural Man(8).
authors.affiliation: Laboratoire des Glucides FRE-CNRS 3517, Institut de Chimie de Picardie, Université de Picardie Jules Verne, 33 Rue Saint-Leu, 80039 Amiens Cedex 1, France.
authors.forename: Virginie
authors.initials: V
authors.lastname: Cendret
authors.forename: Marc
authors.initials: M
authors.lastname: François-Heude
authors.forename: Alejandro
authors.initials: A
authors.lastname: Méndez-Ardoy
authors.forename: Vincent
authors.initials: V
authors.lastname: Moreau
authors.forename: José M García
authors.initials: JM
authors.lastname: Fernández
authors.forename: Florence
authors.initials: F
authors.lastname: Djedaïni-Pilard
mesh_terms: D057930:Click Chemistry; D003208:Concanavalin A / Q000737:chemistry*; D006735:Horseradish Peroxidase / Q000737:chemistry; D008358:Mannose / Q000737:chemistry*; D009844:Oligosaccharides / Q000737:chemistry*; D014230:Triazoles / Q000737:chemistry
chemical_list: D009844:Oligosaccharides; D014230:Triazoles; D003208:Concanavalin A; D006735:Horseradish Peroxidase; D008358:Mannose