title: IsoCor: correcting MS data in isotope labeling experiments.
abstract: Mass spectrometry (MS) is widely used for isotopic labeling studies of metabolism and other biological processes. Quantitative applications-e.g. metabolic flux analysis-require tools to correct the raw MS data for the contribution of all naturally abundant isotopes. IsoCor is a software that allows such correction to be applied to any chemical species. Hence it can be used to exploit any isotopic tracer, from well-known ((13)C, (15)N, (18)O, etc) to unusual ((57)Fe, (77)Se, etc) isotopes. It also provides new features-e.g. correction for the isotopic purity of the tracer-to improve the accuracy of quantitative isotopic studies, and implements an efficient algorithm to process large datasets. Its user-friendly interface makes isotope labeling experiments more accessible to a wider biological community.
  
  
  BACKGROUND
  IsoCor is distributed under OpenSource license at http://metasys.insa-toulouse.fr/software/isocor/
authors.affiliation: Université de Toulouse, 135 Avenue de Rangueil, Toulouse, France.
authors.forename: Pierre
authors.initials: P
authors.lastname: Millard
authors.forename: Fabien
authors.initials: F
authors.lastname: Letisse
authors.forename: Serguei
authors.initials: S
authors.lastname: Sokol
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Portais
mesh_terms: D000465:Algorithms; D007553:Isotope Labeling / Q000379:methods*; D013058:Mass Spectrometry / Q000379:methods*; D012984:Software