title: Visual analytics of brain networks.
abstract: Identification of regions of interest (ROIs) is a fundamental issue in brain network construction and analysis. Recent studies demonstrate that multimodal neuroimaging approaches and joint analysis strategies are crucial for accurate, reliable and individualized identification of brain ROIs. In this paper, we present a novel approach of visual analytics and its open-source software for ROI definition and brain network construction. By combining neuroscience knowledge and computational intelligence capabilities, visual analytics can generate accurate, reliable and individualized ROIs for brain networks via joint modeling of multimodal neuroimaging data and an intuitive and real-time visual analytics interface. Furthermore, it can be used as a functional ROI optimization and prediction solution when fMRI data is unavailable or inadequate. We have applied this approach to an operation span working memory fMRI/DTI dataset, a schizophrenia DTI/resting state fMRI (R-fMRI) dataset, and a mild cognitive impairment DTI/R-fMRI dataset, in order to demonstrate the effectiveness of visual analytics. Our experimental results are encouraging.
authors.affiliation: School of Automation, Northwestern Polytechnical University, Xi'an, China.
authors.forename: Kaiming
authors.initials: K
authors.lastname: Li
authors.forename: Lei
authors.initials: L
authors.lastname: Guo
authors.forename: Carlos
authors.initials: C
authors.lastname: Faraco
authors.forename: Dajiang
authors.initials: D
authors.lastname: Zhu
authors.forename: Hanbo
authors.initials: H
authors.lastname: Chen
authors.forename: Yixuan
authors.initials: Y
authors.lastname: Yuan
authors.forename: Jinglei
authors.initials: J
authors.lastname: Lv
authors.forename: Fan
authors.initials: F
authors.lastname: Deng
authors.forename: Xi
authors.initials: X
authors.lastname: Jiang
authors.forename: Tuo
authors.initials: T
authors.lastname: Zhang
authors.forename: Xintao
authors.initials: X
authors.lastname: Hu
authors.forename: Degang
authors.initials: D
authors.lastname: Zhang
authors.forename: L Stephen
authors.initials: LS
authors.lastname: Miller
authors.forename: Tianming
authors.initials: T
authors.lastname: Liu
mesh_terms: D000368:Aged; D001931:Brain Mapping / Q000379:methods*; D060825:Cognitive Dysfunction / Q000473:pathology; D056324:Diffusion Tensor Imaging; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D019359:Knowledge; D008279:Magnetic Resonance Imaging; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology; D009415:Nerve Net / Q000033:anatomy & histology* / Q000473:pathology; D009483:Neuropsychological Tests; D009488:Neurosciences; D015203:Reproducibility of Results; D012559:Schizophrenia / Q000473:pathology; D012565:Schizophrenic Psychology; D012984:Software; D014584:User-Computer Interface; D055815:Young Adult