title: The oxidative phosphorylation system in mammalian mitochondria.
abstract: The chapter provides a review of the state of art of the oxidative phosphorylation system in mammalian mitochondria. The sections of the paper deal with:                                         (i)                                            the respiratory chain as a whole: redox centers of the chain and protonic coupling in oxidative phosphorylation                                                                                (ii)                                            atomic structure and functional mechanism of protonmotive complexes I, III, IV and V of the oxidative phosphorylation system                                                                                (iii)                                            biogenesis of oxidative phosphorylation complexes: mitochondrial import of nuclear encoded subunits, assembly of oxidative phosphorylation complexes, transcriptional factors controlling biogenesis of the complexes.                                                                        This advanced knowledge of the structure, functional mechanism and biogenesis of the oxidative phosphorylation system provides a background to understand the pathological impact of genetic and acquired dysfunctions of mitochondrial oxidative phosphorylation.
authors.affiliation: Department of Basic Medical Sciences, University of Bari, Bari, Italy. s.papa@biochem.uniba.it
authors.forename: Sergio
authors.initials: S
authors.lastname: Papa
authors.forename: Pietro Luca
authors.initials: PL
authors.lastname: Martino
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Capitanio
authors.forename: Antonio
authors.initials: A
authors.lastname: Gaballo
authors.forename: Domenico
authors.initials: D
authors.lastname: De Rasmo
authors.forename: Anna
authors.initials: A
authors.lastname: Signorile
authors.forename: Vittoria
authors.initials: V
authors.lastname: Petruzzella
mesh_terms: D000818:Animals; D004579:Electron Transport; D008928:Mitochondria / Q000378:metabolism*; D008958:Models, Molecular; D010085:Oxidative Phosphorylation