title: Hyperbranched double hydrophilic block copolymer micelles of poly(ethylene oxide) and polyglycerol for pH-responsive drug delivery.
abstract: We report the synthesis of a well-defined hyperbranched double hydrophilic block copolymer of poly(ethylene oxide)-hyperbranched-polyglycerol (PEO-hb-PG) to develop an efficient drug delivery system. In specific, we demonstrate the hyperbranched PEO-hb-PG can form a self-assembled micellar structure on conjugation with the hydrophobic anticancer agent doxorubicin, which is linked to the polymer by pH-sensitive hydrazone bonds, resulting in a pH-responsive controlled release of doxorubicin. Dynamic light scattering, atomic force microscopy, and transmission electron microscopy demonstrated successful formation of the spherical core-shell type micelles with an average size of about 200 nm. Moreover, the pH-responsive release of doxorubicin and in vitro cytotoxicity studies revealed the controlled stimuli-responsive drug delivery system desirable for enhanced efficiency. Benefiting from many desirable features of hyperbranched double hydrophilic block copolymers such as enhanced biocompatibility, increased water solubility, and drug loading efficiency as well as improved clearance of the polymer after drug release, we believe that double hydrophilic block copolymer will provide a versatile platform to develop excellent drug delivery systems for effective treatment of cancer.
authors.affiliation: Interdisciplinary School of Green Energy, Ulsan National Institute of Science and Technology (UNIST), Ulsan, Korea.
authors.forename: Sueun
authors.initials: S
authors.lastname: Lee
authors.forename: Kyohei
authors.initials: K
authors.lastname: Saito
authors.forename: Hye-Ra
authors.initials: HR
authors.lastname: Lee
authors.forename: Min Jae
authors.initials: MJ
authors.lastname: Lee
authors.forename: Yuji
authors.initials: Y
authors.lastname: Shibasaki
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Oishi
authors.forename: Byeong-Su
authors.initials: BS
authors.lastname: Kim
mesh_terms: D016503:Drug Delivery Systems; D005990:Glycerol / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D057927:Hydrophobic and Hydrophilic Interactions; D008422:Materials Testing; D008823:Micelles; D008958:Models, Molecular; D015394:Molecular Structure; D011092:Polyethylene Glycols / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D012995:Solubility; D014867:Water / Q000737:chemistry
chemical_list: D008823:Micelles; D011108:Polymers; D014867:Water; C043941:polyglycerol; D011092:Polyethylene Glycols; D005990:Glycerol