title: Nickel-catalysed aromatic Finkelstein reaction of aryl and heteroaryl bromides.
abstract: A fast and efficient nickel-catalysed iodination reaction of aryl and heteroaryl bromides has been developed. The transformation was found to be general for a wide range of substrates and was used for the synthesis of iodo-PK11195, an imaging agent of Alzheimer's disease and iniparib, a compound used in the treatment of breast cancer.
authors.affiliation: WestCHEM, School of Chemistry, The Joseph Black Building, University of Glasgow, Glasgow G12 8QQ, UK.
authors.forename: Alastair A
authors.initials: AA
authors.lastname: Cant
authors.forename: Rajiv
authors.initials: R
authors.lastname: Bhalla
authors.forename: Sally L
authors.initials: SL
authors.lastname: Pimlott
authors.forename: Andrew
authors.initials: A
authors.lastname: Sutherland
mesh_terms: D001554:Benzene / Q000138:chemical synthesis* / Q000737:chemistry*; D001966:Bromine / Q000737:chemistry*; D002384:Catalysis; D007700:Kinetics; D008872:Microwaves; D009532:Nickel / Q000737:chemistry*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D009532:Nickel; D001554:Benzene; D001966:Bromine