title: Intrauterine upper extremity thrombosis successfully treated with recombinant tissue plasminogen activator, enoxaparin and collagenase.
abstract: Intrauterine ischemia of the limbs is a rare condition involving thrombosis and ischemia of the extremities before birth. The clinical presentation depends on the extremity affected as well as the timing of thrombosis. Very few cases with extremity hypoperfusion and gangrene due to intrauterine thrombosis have been reported in the literature, and therefore there is no consensus on the optimal therapeutic strategy for such cases. Presented here is a case of a newborn with intrauterine brachial arterial thrombosis of the right upper extremity who was successfully treated by a combination of recombinant tissue plasminogen activator, enoxaparin and collagenase application followed by surgery.
authors.affiliation: Division of Neonatology, Zekai Tahir Burak Maternity Teaching Hospital, Ankara, Turkey. sdkyurttutan@gmail.com
authors.forename: Sadik
authors.initials: S
authors.lastname: Yurttutan
authors.forename: Ramazan
authors.initials: R
authors.lastname: Ozdemir
authors.forename: Omer
authors.initials: O
authors.lastname: Erdeve
authors.forename: Erhan
authors.initials: E
authors.lastname: Calisici
authors.forename: Mehmet Yekta
authors.initials: MY
authors.lastname: Oncel
authors.forename: Serife Suna
authors.initials: SS
authors.lastname: Oguz
authors.forename: Ugur
authors.initials: U
authors.lastname: Dilmen
mesh_terms: D017364:Collagenases / Q000627:therapeutic use*; D017984:Enoxaparin / Q000627:therapeutic use*; D005315:Fetal Diseases / Q000175:diagnosis*; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009336:Necrosis; D011994:Recombinant Proteins / Q000235:genetics / Q000378:metabolism / Q000627:therapeutic use; D013927:Thrombosis / Q000188:drug therapy* / Q000473:pathology; D010959:Tissue Plasminogen Activator / Q000235:genetics / Q000378:metabolism / Q000627:therapeutic use*; D034941:Upper Extremity / Q000473:pathology
chemical_list: D017984:Enoxaparin; D005343:Fibrinolytic Agents; D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator; D017364:Collagenases