title: [Interstitial lung disease in rheumatoid arthritis].
abstract: Interstitial lung disease (ILD) is found in up to 30% of patients with rheumatoid arthritis (RA) and is clinically manifest in 5 to 10%, resulting in significant morbidity and mortality. The most frequent histopathological forms are usual interstitial pneumonia and nonspecific interstitial pneumonia. Another recently described presentation is combined pulmonary fibrosis and emphysema. Similarly to idiopathic pulmonary fibrosis, acute exacerbation of ILD may occur in RA and is associated with severe prognosis. Smoking is a known risk factor of RA and may also play a role in the pathogenesis of RA-associated ILD, in combination with genetic and immunologic mechanisms. Several treatments of RA may also lead to drug-induced ILD.
authors.affiliation: Consultation des pneumopathies interstitielles et maladies pulmonaires rares, Service de pneumologie, Département de médecine, CHUV, Lausanne. sylvie_janin@hotmail.com
authors.forename: Sylvie
authors.initials: S
authors.lastname: Froidevaux-Janin
authors.forename: Jean
authors.initials: J
authors.lastname: Dudler
authors.forename: Laurent P
authors.initials: LP
authors.lastname: Nicod
authors.forename: Romain
authors.initials: R
authors.lastname: Lazor
mesh_terms: D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D018450:Disease Progression; D042241:Early Diagnosis; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000150:complications* / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D008954:Models, Biological; D011379:Prognosis; D012307:Risk Factors