title: The role of co-occurring disruptive behavior in the clinical presentation of children and adolescents with anxiety in the context of autism spectrum disorders.
abstract: This study explored the impact of disruptive behavior disorder (DBD) comorbidity on theoretically relevant correlates among 87 children and adolescents with autism spectrum disorders (ASD) and clinically significant anxiety. Relative to youth with ASD and anxiety alone, participants with ASD, anxiety, and DBD: (a) presented with significantly more severe anxiety symptoms per clinician-, parent-, and self-report; (b) were more likely to be prescribed antipsychotic medication but were no more likely to receive additional psychosocial and educational interventions; and (c) experienced significantly greater functional impairment and family interference. These results suggest that co-occurring DBD in the context of ASD and anxiety confers greater risk for heightened symptom severity and functional impairment, and may be linked with increased prescription of antipsychotic medication.
authors.affiliation: Department of Pediatrics, Rothman Center for Neuropsychiatry, University of South Florida, 800 6th Street South, 4th Floor North, Box 7523, St. Petersburg, FL 33701, USA. estorch@health.usf.edu
authors.forename: Eric A
authors.initials: EA
authors.lastname: Storch
authors.forename: Elysse B
authors.initials: EB
authors.lastname: Arnold
authors.forename: Anna M
authors.initials: AM
authors.lastname: Jones
authors.forename: Chelsea M
authors.initials: CM
authors.lastname: Ale
authors.forename: Jeffrey J
authors.initials: JJ
authors.lastname: Wood
authors.forename: Jill
authors.initials: J
authors.lastname: Ehrenreich-May
authors.forename: Adam B
authors.initials: AB
authors.lastname: Lewin
authors.forename: P Jane
authors.initials: PJ
authors.lastname: Mutch
authors.forename: Tanya K
authors.initials: TK
authors.lastname: Murphy
mesh_terms: D000293:Adolescent; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001007:Anxiety / Q000175:diagnosis*; D019958:Attention Deficit and Disruptive Behavior Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology / Q000628:therapy; D002648:Child; D002652:Child Behavior / Q000187:drug effects; D002659:Child Development Disorders, Pervasive / Q000175:diagnosis / Q000453:epidemiology / Q000523:psychology / Q000628:therapy; D015897:Comorbidity; D018479:Early Intervention, Educational / Q000379:methods; D005195:Family Relations; D005260:Female; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D018570:Risk Assessment; D012944:Social Support
chemical_list: D014150:Antipsychotic Agents