title: Dietary nitrate and nitrite intake and non-Hodgkin lymphoma survival.
abstract: Nitrate and nitrite are precursors in the formation of N-nitroso compounds. We recently found a 40% increased risk of NHL with higher dietary nitrite intake and significant increases in risk for follicular and T-cell lymphoma. It is possible that these compounds also affect NHL prognosis by enhancing cancer progression in addition to development by further impairing immune system function. To test the hypothesis that nitrate and nitrite intake affects NHL survival, we evaluated the association in study participants that have been followed post-disease diagnosis in a population-based case-control study among women in Connecticut. We did not observe a significant increasing trend of mortality for NHL overall or by subtype for nitrate or nitrite intake for deaths from NHL or death from any cause, although a borderline significant protective trend was observed for follicular lymphoma with increasing nitrate intake. We did not identify a difference in overall survival for nitrate (P = 0.39) or for nitrite (P = 0.66) or for NHL specific survival for nitrate (P = 0.96) or nitrite (P = 0.17). Thus, our null findings do not confer support for the possibility that dietary nitrate and nitrite intake impacts NHL survival by promoting immune unresponsiveness.
authors.affiliation: Department of Health Studies, University of Chicago, Chicago, Illinois 60637, USA. brisa@uchicago.edu
authors.forename: Briseis
authors.initials: B
authors.lastname: Aschebrook-Kilfoy
authors.forename: Mary H
authors.initials: MH
authors.lastname: Ward
authors.forename: Tongzhang
authors.initials: T
authors.lastname: Zheng
authors.forename: Theodore R
authors.initials: TR
authors.lastname: Holford
authors.forename: Peter
authors.initials: P
authors.lastname: Boyle
authors.forename: Brian
authors.initials: B
authors.lastname: Leaderer
authors.forename: Yawei
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D003237:Connecticut; D004032:Diet; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000401:mortality* / Q000503:physiopathology; D008875:Middle Aged; D015999:Multivariate Analysis; D009566:Nitrates / Q000008:administration & dosage*; D009573:Nitrites / Q000008:administration & dosage*; D012307:Risk Factors; D055815:Young Adult
chemical_list: D009566:Nitrates; D009573:Nitrites