title: Myeloid suppressor cells and immune modulation in lung cancer.
abstract: Many tumors, including lung cancers, promote immune tolerance to escape host immune surveillance and facilitate tumor growth. Tumors utilize numerous pathways to inhibit immune responses, including the elaboration of immune-suppressive mediators such as PGE2, TGF-β, IL-10, VEGF, GM-CSF, IL-6, S100A8/A9 and SCF, which recruit and/or activate myeloid-derived suppressor cells (MDSCs). MDSCs, a subset of heterogeneous bone marrow-derived hematopoietic cells, are found in the peripheral blood of cancer patients and positively correlate to malignancy. Solid tumors contain MDSCs that maintain an immune-suppressive network in the tumor microenvironment. This review will focus on the interaction of tumors with MDSCs that lead to dysregulation of antigen presentation and T-cell activities in murine tumor models. Specific genetic signatures in lung cancer modulate the activities of MDSCs and impact tumor progression. Targeting MDSCs may have a long-term antitumor benefit and is at the forefront of anticancer therapeutic strategies.
authors.affiliation: University of California Los Angeles & Veterans Affairs Greater Los Angeles, CA, USA.
authors.forename: Minu K
authors.initials: MK
authors.lastname: Srivastava
authors.forename: Åsa
authors.initials: Å
authors.lastname: Andersson
authors.forename: Li
authors.initials: L
authors.lastname: Zhu
authors.forename: Marni
authors.initials: M
authors.lastname: Harris-White
authors.forename: Jay M
authors.initials: JM
authors.lastname: Lee
authors.forename: Steven
authors.initials: S
authors.lastname: Dubinett
authors.forename: Sherven
authors.initials: S
authors.lastname: Sharma
mesh_terms: D000818:Animals; D017951:Antigen Presentation; D000951:Antigens, Neoplasm / Q000276:immunology; D001854:Bone Marrow Cells / Q000276:immunology* / Q000473:pathology; D040501:Calgranulin A / Q000276:immunology; D040502:Calgranulin B / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D015232:Dinoprostone / Q000276:immunology; D006801:Humans; D056747:Immunomodulation; D008175:Lung Neoplasms / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D051379:Mice; D022423:Myeloid Cells / Q000276:immunology* / Q000473:pathology; D009374:Neoplasms, Experimental / Q000276:immunology / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology; D019139:Tumor Escape; D059016:Tumor Microenvironment
chemical_list: D000951:Antigens, Neoplasm; D040501:Calgranulin A; D040502:Calgranulin B; D016207:Cytokines; D015232:Dinoprostone