title: Microfabricated biomaterials for engineering 3D tissues.
abstract: Mimicking natural tissue structure is crucial for engineered tissues with intended applications ranging from regenerative medicine to biorobotics. Native tissues are highly organized at the microscale, thus making these natural characteristics an integral part of creating effective biomimetic tissue structures. There exists a growing appreciation that the incorporation of similar highly organized microscale structures in tissue engineering may yield a remedy for problems ranging from vascularization to cell function control/determination. In this review, we highlight the recent progress in the field of microscale tissue engineering and discuss the use of various biomaterials for generating engineered tissue structures with microscale features. In particular, we will discuss the use of microscale approaches to engineer the architecture of scaffolds, generate artificial vasculature, and control cellular orientation and differentiation. In addition, the emergence of microfabricated tissue units and the modular assembly to emulate hierarchical tissues will be discussed.
authors.affiliation: Center for Biomedical Engineering, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Cambridge, MA 02139, USA.
authors.forename: Pinar
authors.initials: P
authors.lastname: Zorlutuna
authors.forename: Nasim
authors.initials: N
authors.lastname: Annabi
authors.forename: Gulden
authors.initials: G
authors.lastname: Camci-Unal
authors.forename: Mehdi
authors.initials: M
authors.lastname: Nikkhah
authors.forename: Jae Min
authors.initials: JM
authors.lastname: Cha
authors.forename: Jason W
authors.initials: JW
authors.lastname: Nichol
authors.forename: Amir
authors.initials: A
authors.lastname: Manbachi
authors.forename: Hojae
authors.initials: H
authors.lastname: Bae
authors.forename: Shaochen
authors.initials: S
authors.lastname: Chen
authors.forename: Ali
authors.initials: A
authors.lastname: Khademhosseini
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry* / Q000378:metabolism; D064987:Cell- and Tissue-Based Therapy / Q000191:economics; D006801:Humans; D011108:Polymers / Q000737:chemistry; D044968:Regenerative Medicine / Q000191:economics; D023822:Tissue Engineering / Q000191:economics; D014466:Ultraviolet Rays
chemical_list: D001672:Biocompatible Materials; D011108:Polymers