title: Crossing the Rubicon: new roads lead to host defense.
abstract: Rubicon is a protein known to engage the Beclin-1/Vps34-PI3K/UVRAG complex and inhibit endosome and autophagosomal fusion with lysosomes. Yang et al. (2012) uncover new roles for this adaptor protein within noncanonical p22(phox) or CARD9 complexes that regulate oxidative and cytokine responses in activated macrophages, respectively. Both complexes impact pathogen-specific host defense.
authors.affiliation: Section of Microbial Pathogenesis, Boyer Centre for Molecular Medicine, Yale University School of Medicine, New Haven, CT 06510, USA.
authors.forename: Clinton J
authors.initials: CJ
authors.lastname: Bradfield
authors.forename: Bae-Hoon
authors.initials: BH
authors.lastname: Kim
authors.forename: John D
authors.initials: JD
authors.lastname: MacMicking