title: Hypereosinophilia driven by GM-CSF in large-cell carcinoma of the lung.
abstract: In contrast to leukocytosis, paraneoplastic hypereosinophilia is uncommon in lung cancer. We present a patient with large-cell carcinoma of the lung, in which cancer cells generate large amounts of GM-CSF leading to a leukemoid reaction with prominent hypereosinophilia and potentially involved in autocrine tumor stimulation.
authors.affiliation: Department of Internal Medicine, Kantonsspital Graubünden, Chur, Switzerland.
authors.forename: Verena
authors.initials: V
authors.lastname: Lammel
authors.forename: Christina
authors.initials: C
authors.lastname: Stoeckle
authors.forename: Barbara
authors.initials: B
authors.lastname: Padberg
authors.forename: Roland
authors.initials: R
authors.lastname: Zweifel
authors.forename: Dirk L
authors.initials: DL
authors.lastname: Kienle
authors.forename: Walter H
authors.initials: WH
authors.lastname: Reinhart
authors.forename: Hans-Uwe
authors.initials: HU
authors.lastname: Simon
mesh_terms: D018287:Carcinoma, Large Cell / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism*; D004802:Eosinophilia / Q000175:diagnosis / Q000209:etiology*; D017809:Fatal Outcome; D016179:Granulocyte Colony-Stimulating Factor / Q000097:blood*; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism*; D008297:Male; D008875:Middle Aged
chemical_list: D016179:Granulocyte Colony-Stimulating Factor