title: B-type natriuretic peptide predicts new-onset atrial fibrillation in patients with ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention.
abstract: The predictive value of B-type natriuretic peptide (BNP) with respect to the occurrence of new-onset atrial fibrillation (AF) in patients with ST-segment elevation myocardial infarction (STEMI) treated by primary percutaneous coronary intervention (PCI) is unknown. The aim of this study was to evaluate whether BNP has a predictive value for the occurrence of new-onset AF in patients with STEMI treated by primary PCI. In 180 patients with STEMI treated by primary PCI, BNP concentrations were measured 24h after chest pain onset. The Receiver Operating Characteristic analysis was performed to identify the most useful BNP cut-off level for the prediction of AF. The patients were divided into the two groups according to calculated cut-off level: high BNP group (BNP≥720 pg/mL, n=33) and low BNP group (BNP<720 pg/mL, n=147). The incidence of AF was 5.0%, and occurred more frequently in high BNP group (7/33, 21.2%) than in low BNP group (2/147, 1.4%), (p<0.001). Patients with high BNP were older (p=0.017), had more often anterior wall infarction (p=0.015), higher Killip class on admission (p=0.038), higher peak troponin I (p=0.002), lower left ventricular ejection fraction (p=0.029) than patients with low BNP. After multivariate adjustment, BNP was an independent predictor of AF (OR 3.70, 95% CI 1.40-9.77, p=0.008). BNP independently predicts the occurrence of new-onset AF in STEMI patients treated by primary PCI.
authors.affiliation: Cardiology Clinic, Clinical Center of Serbia, School of Medicine University of Belgrade, Belgrade, Serbia. masanin@eunet.rs
authors.forename: Milika
authors.initials: M
authors.lastname: Asanin
authors.forename: Sanja
authors.initials: S
authors.lastname: Stankovic
authors.forename: Igor
authors.initials: I
authors.lastname: Mrdovic
authors.forename: Dragan
authors.initials: D
authors.lastname: Matic
authors.forename: Lidija
authors.initials: L
authors.lastname: Savic
authors.forename: Nada
authors.initials: N
authors.lastname: Majkic-Singh
authors.forename: Miodrag
authors.initials: M
authors.lastname: Ostojic
authors.forename: Zorana
authors.initials: Z
authors.lastname: Vasiljevic
mesh_terms: D000368:Aged; D017130:Angioplasty; D019540:Area Under Curve; D001281:Atrial Fibrillation / Q000097:blood / Q000175:diagnosis* / Q000209:etiology; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000097:blood* / Q000150:complications / Q000628:therapy; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D016017:Odds Ratio; D012372:ROC Curve; D018709:Statistics, Nonparametric
chemical_list: D015415:Biomarkers; D020097:Natriuretic Peptide, Brain