title: Acute Toxicity and General Pharmacological Action of QGC EXT.
abstract: It has been shown that QGC isolated and purified from Rumecis folium found protective effects of gastritis and esophagitis which EXT is an ethanol extract of it. We examined acute toxicity and the general pharmacological action of QGC EXT to search for any side effects of it in rats, mice, guinea pigs, and cats. In a single dose toxicity study, QGC EXT didn't show toxicological effects in rats and mice, and the LD(50) was over 5 g/kg in both animals, and there were also no changes in weight, feed and water intake during these toxicological experimental periods. We examined the general pharmacological action on central controlled behavior responses, and peripheral organs including blood pressure, heart rate, respiration and gastrointestinal system, We found that there were no significant changes in body temperature, locomotors activity, stereotyped behaviors, sleeping time, and convulsion. In other studies, writhing reaction, normal body temperature, there did not appear to be any changes. The large intestine movement and electrical field stimulation-induced contraction was not changes by its EXT. In addition, the influences on blood pressure, heart rates, and respiration by QGC EXT were not found. These results indicate that QGC EXT may be very safe as a new drug, since its LD(50) was very high over 5 g/kg and any side effects were not found.
authors.affiliation: Department of Pharmacology, College of Pharmacy, Chung-Ang University, Seoul 156-756, Korea.
authors.forename: Jong Mi
authors.initials: JM
authors.lastname: Lee
authors.forename: Wi Joon
authors.initials: WJ
authors.lastname: Im
authors.forename: Yoon Jin
authors.initials: YJ
authors.lastname: Nam
authors.forename: Kyung Hoon
authors.initials: KH
authors.lastname: Oh
authors.forename: Jae Chun
authors.initials: JC
authors.lastname: Lim
authors.forename: Wan Kyunn
authors.initials: WK
authors.lastname: Whang
authors.forename: Uy Dong
authors.initials: UD
authors.lastname: Sohn