title: First human case of co-infection with two different subtypes of hepatitis E virus.
abstract: Hepatitis E virus (HEV), the main etiologic agent of enterically transmitted acute hepatitis in developing countries, is now recognized as an emerging agent of autochthonous disease and chronic hepatitis E in immunocompromised patients in Europe where HEV infection is probably zoonotically acquired. We describe the first human case of acute HEV infection with two genotype 3 viruses in a French kidney transplant recipient, probably acquired through consumption of uncooked pig liver sausage (figatellu). The patient presented two viral sequences nearly identical to sequences recovered from figatelli. Autochthonous co-infections with different genotype 3 HEV strains can occur in our geographical area.
authors.affiliation: Centre de Néphrologie et Transplantation Rénale, Hôpital Conception, Assistance Publique des Hôpitaux de Marseille, Aix-Marseille Université, Marseille, France. vmoal@ap-hm.fr
authors.forename: Valérie
authors.initials: V
authors.lastname: Moal
authors.forename: René
authors.initials: R
authors.lastname: Gerolami
authors.forename: Philippe
authors.initials: P
authors.lastname: Colson
mesh_terms: D000368:Aged; D060085:Coinfection; D042882:Gallstones / Q000150:complications; D006508:Hepatitis Antibodies / Q000097:blood; D016751:Hepatitis E / Q000150:complications / Q000276:immunology / Q000821:virology*; D016752:Hepatitis E virus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D016867:Immunocompromised Host; D016030:Kidney Transplantation; D008297:Male; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics
chemical_list: D006508:Hepatitis Antibodies; D012367:RNA, Viral