title: Synthetic and semi-synthetic chondroitin sulfate oligosaccharides, polysaccharides, and glycomimetics.
abstract: Chondroitin sulfate (CS) is a sulfated polysaccharide involved in a myriad of biological processes. Due to the variable sulfation pattern of CS polymer chains, the need to study in detail structure-activity relationships regarding CS biomedical features has provoked much interest in obtaining synthetic CS species. This paper reviews two decades of synthetic and semi-synthetic CS oligosaccharides, polysaccharides, and glycomimetics obtained by chemical, chemoenzymatic, enzymatic, and microbiological-chemical strategies.
authors.affiliation: Dipartimento di Scienze Chimiche, Università di Napoli Federico II, Complesso Universitario Monte S. Angelo, via Cintia 4, 80126 Napoli, Italy. ebedini@unina.it
authors.forename: Emiliano
authors.initials: E
authors.lastname: Bedini
authors.forename: Michelangelo
authors.initials: M
authors.lastname: Parrilli
mesh_terms: D055162:Biocatalysis; D040761:Biomimetic Materials / Q000138:chemical synthesis*; D019921:Biotinylation; D002240:Carbohydrate Sequence; D002809:Chondroitin Sulfates / Q000096:biosynthesis / Q000138:chemical synthesis*; D020650:Combinatorial Chemistry Techniques; D005688:Galactosamine / Q000737:chemistry; D005947:Glucose / Q000737:chemistry; D020723:Glucuronic Acid / Q000737:chemistry; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000096:biosynthesis / Q000138:chemical synthesis*; D054852:Small Molecule Libraries; D013329:Structure-Activity Relationship; D013431:Sulfates / Q000737:chemistry*
chemical_list: D009844:Oligosaccharides; D054852:Small Molecule Libraries; D013431:Sulfates; D005688:Galactosamine; D020723:Glucuronic Acid; D002809:Chondroitin Sulfates; D005947:Glucose