title: Theranostic Imaging of the Kinases and Proteases that Modulate Cell Death and Survival.
abstract: Several signaling cascades are involved in cell death, with a significant amount of crosstalk between them. Despite the complexity of these cascades several key pro-survival and pro-death players have been identified. These include PI3-kinase, AKT and caspase-3. Here we review the approaches used to date to perform molecular imaging of these important targets. We focus in particular on approaches that include the possibility of modulating the activity of these kinases and proteases in a theranostic approach.
authors.affiliation: 1. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston MA.
authors.forename: Howard H
authors.initials: HH
authors.lastname: Chen
authors.forename: Hushan
authors.initials: H
authors.lastname: Yuan
authors.forename: Lee
authors.initials: L
authors.lastname: Josephson
authors.forename: David E
authors.initials: DE
authors.lastname: Sosnovik