title: On-chip stochastic resonance of ion channel systems with variable internal noise.
abstract: We induced stochastic resonance in planar lipid bilayer systems with alamethicin ion channels, and varied alamethicin concentration, membrane area, and applied voltage. We found that membrane-induced microphonic noise significantly affects the signature of stochastic resonance, and that this noise can be used to optimize ion channel-based biosensors.
authors.affiliation: Institut für Angewandte Physik und Zentrum für Mikrostrukturforschung, Universität Hamburg, 20355 Hamburg, Germany. estava@physnet.uni-hamburg.de
authors.forename: Eric
authors.initials: E
authors.lastname: Stava
authors.forename: Siyoung
authors.initials: S
authors.lastname: Choi
authors.forename: Hyun-Seok
authors.initials: HS
authors.lastname: Kim
authors.forename: Robert H
authors.initials: RH
authors.lastname: Blick
mesh_terms: D000408:Alamethicin / Q000378:metabolism; D015374:Biosensing Techniques / Q000379:methods*; D017097:Electric Impedance; D007473:Ion Channels / Q000737:chemistry*; D056656:Lab-On-A-Chip Devices; D008051:Lipid Bilayers / Q000737:chemistry; D008962:Models, Theoretical; D059629:Signal-To-Noise Ratio; D013269:Stochastic Processes
chemical_list: D007473:Ion Channels; D008051:Lipid Bilayers; D000408:Alamethicin