title: Inflammatory pseudotumor of the cerebellum in a patient with Crohn's disease.
abstract: BACKGROUND
  Inflammatory pseudotumors are ubiquitous lesions characterized by a polymorphous inflammatory infiltrate containing plasma cells and lymphocytes. In the central nervous system, this pathological condition is rare and the association with Crohn's disease has never been described.
  
  
  METHODS
  A 31-year-old woman with a history of Crohn's disease was referred to our department for progressive headaches and nausea. Neurological examination was normal. Magnetic resonance imaging showed an irregular heterogeneous enhanced mass infiltrating the left cerebellar hemisphere. Total resection was performed and pathological examination led to the conclusion of an inflammatory pseudotumor.
  
  
  CONCLUSIONS
  To our knowledge, this case is the first describing an intra-cerebral inflammatory pseudotumor associated with an inflammatory bowel disease. The diagnosis of an extradigestive location of Crohn's disease was excluded by pathological examination. Although the precise cause of this association remains unknown, it could be hypothesized that the intra-cranial lesion could be the result of the immunosuppressive therapy given for Crohn's disease, or, more likely, could be a part of a systemic dysimmune process.
authors.affiliation: Department of Neurosurgery, Rouen University Hospital, Rouen, France. stephane.derrey@chu-rouen.fr
authors.forename: Stéphane
authors.initials: S
authors.lastname: Derrey
authors.forename: Cloé
authors.initials: C
authors.lastname: Charpentier
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Gérardin
authors.forename: Olivier
authors.initials: O
authors.lastname: Langlois
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Touchais
authors.forename: Eric
authors.initials: E
authors.lastname: Lerebours
authors.forename: François
authors.initials: F
authors.lastname: Proust
authors.forename: Annie
authors.initials: A
authors.lastname: Laquerrière
mesh_terms: D000328:Adult; D002526:Cerebellar Diseases / Q000150:complications / Q000473:pathology* / Q000601:surgery*; D003424:Crohn Disease / Q000150:complications*; D005260:Female; D006104:Granuloma, Plasma Cell / Q000150:complications / Q000473:pathology* / Q000601:surgery*; D006261:Headache / Q000209:etiology; D006801:Humans; D007249:Inflammation / Q000473:pathology / Q000601:surgery; D008279:Magnetic Resonance Imaging; D009325:Nausea / Q000209:etiology; D019635:Neurosurgical Procedures; D016896:Treatment Outcome