title: Pharmacological treatment of heterotopic ossification following hip surgery: an update.
abstract: Heterotopic ossification is a frequent complication following total hip arthroplasty and acetabular surgery. Formation of ectopic lamellar bone in tissues that exhibit no potential for ossification can lead to associated pain and decrease in function. Prophylaxis and treatment protocols aim to reduce the incidence, by both the use of nonsteroidal anti-inflammatory drug (NSAID) regimens and localized radiotherapy. New therapeutic modalities including bone morphogenetic proteins (BMP) inhibitors like Noggin, BMP type 1 receptor inhibition, nuclear retinoic acid receptor-gamma agonists (RAR-γ), and free radical scavengers are currently under investigation.
authors.forename: George
authors.initials: G
authors.lastname: Pavlou
authors.forename: Margaritis
authors.initials: M
authors.lastname: Kyrkos
authors.forename: Evaggelos
authors.initials: E
authors.lastname: Tsialogiannis
authors.forename: Nectarios
authors.initials: N
authors.lastname: Korres
authors.forename: Eleftherios
authors.initials: E
authors.lastname: Tsiridis
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D006801:Humans; D009999:Ossification, Heterotopic / Q000188:drug therapy*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal