title: [Relationship between insulin, leptin, and melatonin contents in patients with metabolic syndrome].
abstract: Melatonin, leptin, and insulin secretion was studied in 25 men with metabolic syndrome (MS) verified against IDF criteria (2005) (mean age 44 +/- 2 yr). The control group was constituted by 23 healthy men (mean age 45.1 yr). Melatonin secretion was estimated from 6-oxymelatonin sulfate (6-OMS) level in urine samples collected at 4 a.m. (in the darkness). It was shown to increase at this time in both groups but was lower in MS patients than in controls (t = 2, p < 0.05). The Pearson correlation analysis revealed moderate negative correlation between 6-SOMT level in urine and insulin and glucose levels in plasma (r = 0.95). Peak 6-SOMT level showed strong negative correlation with the leptin level. Multiple regression analysis demonstrated strong linear relationship of 6-OMS and insulin levels (r = 0.93) and 6SOMT and leptin levels (r = 0.95). The calculated odds ratio suggests that the risk of insulin resistance in patients displaying a peakless melatonin secretion profile is 3 times that in control subjects (OR = 3.0; 95% CI = 1.3-7). It is concluded that patients with MS present with disturbances of melatonin secretion manifest as the absence of its physiological elevation at night hours; they are characterized by negative correlation between melatonin, leptin and insulin levels and changes in melatonin secretion in relation to abnormal production of insulin and leptin.
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000096:biosynthesis; D015536:Down-Regulation / Q000502:physiology; D006801:Humans; D007328:Insulin / Q000096:biosynthesis* / Q000097:blood / Q000378:metabolism; D000078790:Insulin Secretion; D020738:Leptin / Q000037:antagonists & inhibitors* / Q000096:biosynthesis / Q000097:blood; D008297:Male; D008550:Melatonin / Q000037:antagonists & inhibitors* / Q000097:blood / Q000652:urine; D024821:Metabolic Syndrome / Q000097:blood* / Q000503:physiopathology; D008875:Middle Aged; D016017:Odds Ratio; D012306:Risk
chemical_list: D001786:Blood Glucose; D007328:Insulin; D020738:Leptin; D008550:Melatonin