title: Beta-blocker management in high-risk patients presenting for non-cardiac surgery: before and after the POISE Trial.
abstract: The POISE Trial was a randomised, placebo-controlled, double-blind study of the effectiveness of perioperative beta-blockade in preventing cardiac events including death in 8351 patients. Our hypothesis was that knowledge of the results of the POISE Trial would either increase or decrease the use of effective perioperative beta-blockade, depending on the result. Patients presenting for non-cardiac surgery and at risk of perioperative cardiac events were recruited in two cohorts before and after the release of the POISE Trial results. Effective perioperative beta-blockade was defined as heart rate <65 beats per minute for at least 80% of the perioperative period in patients prescribed beta-blockers. Effective perioperative beta-blockade was achieved in 22 (11.5%) of 191 patients prescribed perioperative beta-blockade in the first cohort (n=392) and seven (6%) of 118 patients in the second cohort (n=241) (P=0.10). Effective heart rate control was achieved in 29 (9%) patients prescribed perioperative beta-blockers compared with 10 (3%) patients not prescribed perioperative beta-blockers (P=0.001). The rate of implementation of effective beta-blockade was low before POISE and this did not change significantly after publication. Our finding does not provide reliable evidence of a change in practice as a result of the POISE Trial.
authors.affiliation: Department of Anaesthesia and Pain Management, Royal Melbourne Hospital, University of Melbourne, Australia. kate.leslie@mh.org.au
authors.forename: K
authors.initials: K
authors.lastname: Leslie
authors.forename: P S
authors.initials: PS
authors.lastname: Myles
authors.forename: R
authors.initials: R
authors.lastname: Halliwell
authors.forename: M J
authors.initials: MJ
authors.lastname: Paech
authors.forename: T G
authors.initials: TG
authors.lastname: Short
authors.forename: S
authors.initials: S
authors.lastname: Walker
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D000368:Aged; D000369:Aged, 80 and over; D000758:Anesthesia; D001315:Australia; D001794:Blood Pressure / Q000187:drug effects; D015331:Cohort Studies; D000075202:Contraindications; D003625:Data Collection; D004311:Double-Blind Method; D005260:Female; D006331:Heart Diseases / Q000503:physiopathology / Q000517:prevention & control*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007431:Intraoperative Complications / Q000503:physiopathology / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D009520:New Zealand; D011300:Preoperative Care; D012306:Risk; D012307:Risk Factors; D013514:Surgical Procedures, Operative / Q000009:adverse effects*; D016896:Treatment Outcome
chemical_list: D000319:Adrenergic beta-Antagonists