title: Organometallic ruthenium and iridium transfer-hydrogenation catalysts using coenzyme NADH as a cofactor.
abstract: Artificial enzymes: half-sandwich arene ruthenium(II) and cyclopentadienyl iridium(III) complexes containing N,N-chelated ligands can use NADH as a source of hydride for the reduction of ketones. Moreover, cyclopentadienyl phenanthroline iridium(III) derivatives at micromolar concentrations are robust catalysts for the production of H(2) from NADH in water and can raise the NAD(+)/NADH ratio in cancer cells.
authors.affiliation: Department of Chemistry, University of Warwick, Coventry, UK.
authors.forename: Soledad
authors.initials: S
authors.lastname: Betanzos-Lara
authors.forename: Zhe
authors.initials: Z
authors.lastname: Liu
authors.forename: Abraha
authors.initials: A
authors.lastname: Habtemariam
authors.forename: Ana M
authors.initials: AM
authors.lastname: Pizarro
authors.forename: Bushra
authors.initials: B
authors.lastname: Qamar
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Sadler
mesh_terms: D002384:Catalysis; D045744:Cell Line, Tumor; D056831:Coordination Complexes / Q000737:chemistry; D006801:Humans; D006865:Hydrogenation; D007495:Iridium / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry; D009243:NAD / Q000737:chemistry*; D010084:Oxidation-Reduction; D012428:Ruthenium / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D056831:Coordination Complexes; D007659:Ketones; D014867:Water; D009243:NAD; D007495:Iridium; D012428:Ruthenium