title: Comparison of two exhaled nitric oxide analyzers: the NIOX MINO hand-held electrochemical analyzer and the NOA280i stationary chemiluminescence analyzer.
abstract: OBJECTIVE
  Measurement of the fraction of nitric oxide (FeNO) in exhaled air is useful in the management of asthma. A new hand-held nitric oxide (NO) analyzer, the NIOX MINO, is simple and easy to use in clinical practice. In this study, FeNO values measured using the NIOX MINO were compared with those obtained using a stationary chemiluminescence analyzer, the Sievers NOA280i.
  
  
  METHODS
  FeNO was measured in 100 adults, using both the NIOX MINO and the NOA280i. Nine (9.0%) of these subjects had asthma. The first acceptable measurement with the NIOX MINO and the mean of two acceptable measurements with the NOA280i were compared.
  
  
  RESULTS
  There was a significant correlation between FeNO concentrations measured with the two devices (r = 0.876, P < 0.001). A Bland-Altman plot showed a high degree of agreement between the two devices: the mean inter-device difference was 3.3 parts per billion (ppb), and the 95% limits of agreement were -7.0 and 13.6 ppb. In addition, the mean relative difference was 14.5%, with the 95% limits of agreement being -33.7 and 62.7%. The mean value (± standard error of the mean) for FeNO as measured with the NIOX MINO (18.8 ± 0.9 ppb) was significantly lower than that measured with the NOA280i (22.1 ± 1.2 ppb, P < 0.001).
  
  
  CONCLUSIONS
  There was a significant correlation, but only moderate agreement, between FeNO values measured with the NIOX MINO and those measured with the NOA280i, with the NIOX MINO values being significantly lower than the NOA280i values. Significant differences in FeNO values obtained with these two NO analyzers should be considered when interpreting the results of FeNO measurements.
authors.affiliation: Department of Internal Medicine, Hanyang University College of Medicine, Seongdong-gu, Seoul, Korea.
authors.forename: Sang-Heon
authors.initials: SH
authors.lastname: Kim
authors.forename: Ji-Yong
authors.initials: JY
authors.lastname: Moon
authors.forename: Hyun Jung
authors.initials: HJ
authors.lastname: Kwak
authors.forename: Sa Il
authors.initials: SI
authors.lastname: Kim
authors.forename: Dong Won
authors.initials: DW
authors.lastname: Park
authors.forename: Jee Woo
authors.initials: JW
authors.lastname: Kim
authors.forename: Tae Hyung
authors.initials: TH
authors.lastname: Kim
authors.forename: Jang Won
authors.initials: JW
authors.lastname: Sohn
authors.forename: Dong Ho
authors.initials: DH
authors.lastname: Shin
authors.forename: Sung Soo
authors.initials: SS
authors.lastname: Park
authors.forename: Ho Joo
authors.initials: HJ
authors.lastname: Yoon
mesh_terms: D000328:Adult; D001249:Asthma / Q000378:metabolism*; D001944:Breath Tests / Q000295:instrumentation* / Q000379:methods; D055664:Electrochemical Techniques / Q000295:instrumentation* / Q000379:methods; D004867:Equipment Design; D045853:Exhalation; D005260:Female; D006801:Humans; D008163:Luminescent Measurements / Q000295:instrumentation* / Q000379:methods; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000378:metabolism*
chemical_list: D009569:Nitric Oxide