title: Apple pomace, a by-product from the asturian cider industry, inhibits herpes simplex virus types 1 and 2 in vitro replication: study of its mechanisms of action.
abstract: The anti-herpes simplex virus type 1 and anti-herpes simplex virus type 2 effects of apple pomace, a by-product from the cider-processing industry, were investigated. The mechanisms of antiviral action were assessed using a battery of experiments targeting sequential steps in the viral replication cycle. The anti-herpetic mechanisms of apple pomaces included the inhibition of virus attachment to the cell surface and the arrest of virus entry and uncoating. Quercitrin and procyanidin B2 were found to play a crucial role in the antiviral activity.
authors.affiliation: Asturias Institute of Biotechnology, Department of Biochemistry and Molecular Biology, University of Oviedo, Oviedo, Spain. alvarezrangel@uniovi.es
authors.forename: Angel L
authors.initials: AL
authors.lastname: Alvarez
authors.forename: Santiago
authors.initials: S
authors.lastname: Melón
authors.forename: Kevin P
authors.initials: KP
authors.lastname: Dalton
authors.forename: Inés
authors.initials: I
authors.lastname: Nicieza
authors.forename: Annele
authors.initials: A
authors.lastname: Roque
authors.forename: Belén
authors.initials: B
authors.lastname: Suárez
authors.forename: Francisco
authors.initials: F
authors.lastname: Parra
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D019649:Food Industry; D005638:Fruit; D006561:Herpes Simplex / Q000188:drug therapy / Q000821:virology*; D018259:Herpesvirus 1, Human / Q000187:drug effects* / Q000472:pathogenicity; D018258:Herpesvirus 2, Human / Q000187:drug effects* / Q000472:pathogenicity; D027845:Malus; D008517:Phytotherapy; D028321:Plant Preparations / Q000494:pharmacology* / Q000627:therapeutic use; D014709:Vero Cells; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D028321:Plant Preparations