title: Immunologic correlates of the abscopal effect in a patient with melanoma.
abstract: The abscopal effect is a phenomenon in which local radiotherapy is associated with the regression of metastatic cancer at a distance from the irradiated site. The abscopal effect may be mediated by activation of the immune system. Ipilimumab is a monoclonal antibody that inhibits an immunologic checkpoint on T cells, cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4). We report a case of the abscopal effect in a patient with melanoma treated with ipilimumab and radiotherapy. Temporal associations were noted: tumor shrinkage with antibody responses to the cancer-testis antigen NY-ESO-1, changes in peripheral-blood immune cells, and increases in antibody responses to other antigens after radiotherapy. (Funded by the National Institutes of Health and others.).
authors.affiliation: Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA.
authors.forename: Michael A
authors.initials: MA
authors.lastname: Postow
authors.forename: Margaret K
authors.initials: MK
authors.lastname: Callahan
authors.forename: Christopher A
authors.initials: CA
authors.lastname: Barker
authors.forename: Yoshiya
authors.initials: Y
authors.lastname: Yamada
authors.forename: Jianda
authors.initials: J
authors.lastname: Yuan
authors.forename: Shigehisa
authors.initials: S
authors.lastname: Kitano
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Mu
authors.forename: Teresa
authors.initials: T
authors.lastname: Rasalan
authors.forename: Matthew
authors.initials: M
authors.lastname: Adamow
authors.forename: Erika
authors.initials: E
authors.lastname: Ritter
authors.forename: Christine
authors.initials: C
authors.lastname: Sedrak
authors.forename: Achim A
authors.initials: AA
authors.lastname: Jungbluth
authors.forename: Ramon
authors.initials: R
authors.lastname: Chua
authors.forename: Arvin S
authors.initials: AS
authors.lastname: Yang
authors.forename: Ruth-Ann
authors.initials: RA
authors.lastname: Roman
authors.forename: Samuel
authors.initials: S
authors.lastname: Rosner
authors.forename: Brenna
authors.initials: B
authors.lastname: Benson
authors.forename: James P
authors.initials: JP
authors.lastname: Allison
authors.forename: Alexander M
authors.initials: AM
authors.lastname: Lesokhin
authors.forename: Sacha
authors.initials: S
authors.lastname: Gnjatic
authors.forename: Jedd D
authors.initials: JD
authors.lastname: Wolchok
mesh_terms: D000328:Adult; D000906:Antibodies / Q000097:blood; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D000074324:Ipilimumab; D008175:Lung Neoplasms / Q000188:drug therapy / Q000276:immunology / Q000532:radiotherapy / Q000556:secondary*; D008545:Melanoma / Q000188:drug therapy / Q000276:immunology / Q000532:radiotherapy* / Q000556:secondary; D009362:Neoplasm Metastasis / Q000276:immunology; D012878:Skin Neoplasms / Q000473:pathology*
chemical_list: D000906:Antibodies; D000911:Antibodies, Monoclonal; D000074324:Ipilimumab