title: Construction of a microbial natural product library for chemical biology studies.
abstract: The RIKEN Natural Products Depository (NPDepo) is a public depository of small molecules. Currently, the NPDepo chemical library contains 39,200 pure compounds, half of which are natural products and their derivatives. In order to reinforce the uniqueness of our chemical library, we have improved our strategies for the collection of microbial natural products. Firstly, a microbial metabolite fraction library coupled with an MP (microbial products) plot database provides a powerful resource for the efficient isolation of microbial metabolites. Secondly, biosynthetic studies of microbial metabolites have enabled us to not only access ingenious biosynthetic machineries, but also obtain a variety of biosynthetic intermediates. Our chemical library contributes to the discovery of molecular probes for increasing our understanding of complex biological processes and for eventually developing new drug leads.
authors.affiliation: Chemical Biology Core Facility, Chemical Biology Department, RIKEN Advanced Science Institute, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan.
authors.forename: Naoki
authors.initials: N
authors.lastname: Kato
authors.forename: Shunji
authors.initials: S
authors.lastname: Takahashi
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Nogawa
authors.forename: Tamio
authors.initials: T
authors.lastname: Saito
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Osada
mesh_terms: D000818:Animals; D001419:Bacteria / Q000737:chemistry / Q000378:metabolism*; D001688:Biological Products / Q000737:chemistry* / Q000378:metabolism; D016208:Databases, Factual; D006801:Humans; D020407:Internet; D015202:Protein Engineering
chemical_list: D001688:Biological Products