title: Direct arylation of imidazo[1,2-a]pyridine at C-3 with aryl iodides, bromides, and triflates via copper(I)-catalyzed C-H bond functionalization.
abstract: A convenient method for the copper(I)-catalyzed arylation of substituted imidazo[1,2-a]pyridine has been developed. This method is applicable to a variety of aryl electrophiles, including bromides, iodides, and triflates. It represents the first general process for C-3 arylation of substituted imidazo[1,2-a]pyridine by Cu(I) catalysis to construct various functionalized imidazo[1,2-a]pyridine core π-systems.
authors.affiliation: School of Chemistry and Chemical Engineering, Guangdong Pharmaceutical University, Guangzhou 510006, P. R. China. hua.cao@mail.scut.edu.cn
authors.forename: Hua
authors.initials: H
authors.lastname: Cao
authors.forename: Haiying
authors.initials: H
authors.lastname: Zhan
authors.forename: Yuanguang
authors.initials: Y
authors.lastname: Lin
authors.forename: Xiulian
authors.initials: X
authors.lastname: Lin
authors.forename: Zuodong
authors.initials: Z
authors.lastname: Du
authors.forename: Huanfeng
authors.initials: H
authors.lastname: Jiang
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003300:Copper / Q000737:chemistry*; D006842:Hydrocarbons, Brominated / Q000138:chemical synthesis / Q000737:chemistry*; D006847:Hydrocarbons, Iodinated / Q000138:chemical synthesis / Q000737:chemistry*; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D008698:Mesylates / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D006842:Hydrocarbons, Brominated; D006847:Hydrocarbons, Iodinated; D007093:Imidazoles; D008698:Mesylates; D011725:Pyridines; D003300:Copper