title: Sentinel lymphadenectomy compared to extended lymphadenectomy in men with prostate cancer undergoing prostatectomy.
abstract: BACKGROUND
  To evaluate the reliability of sentinel lymphadenectomy compared to extended lymphadenectomy in men undergoing radical prostatectomy (RP).
  
  
  METHODS
  A consecutive cohort of men with intermediate- to high-risk prostate cancer underwent RP with sentinel LA with intraoperative frozen section. In addition, extended LA was carried out in all cases. The endpoint was lymph node-positivity.
  
  
  RESULTS
  In total, 54 men with a mean age of 65.3 (50.9-75.6) years were analyzed. The mean preoperative prostate-specific antigen was 10.6 (2.8-66.5) ng/ml, mean number of disease-positive cores was 5.8 (1-13), digital rectal examination was positive in 29 men (53.7%). In 12 men (22.2%), a positive lymph node was found (pN1). sLA was positive in 11 cases. One patient had a positive lymph node in eLA not found with sLA. The positive predictive value of frozen section was 50%; the respective figure for sLA compared to eLA was 91.6%.
  
  
  CONCLUSIONS
  In this cohort, revealing a high prevalence of disease-positive lymph nodes, sLA was a reliable technique with a low rate of false negativity.
authors.affiliation: Department of Urology and Andrology, Saint John of God Hospital, Johannes von Gott-Platz 1, 1020 Vienna, Austria.
authors.forename: Anton
authors.initials: A
authors.lastname: Ponholzer
authors.forename: Michael
authors.initials: M
authors.lastname: Lamche
authors.forename: Max
authors.initials: M
authors.lastname: Klitsch
authors.forename: Nicole
authors.initials: N
authors.lastname: Kraischits
authors.forename: Manuela
authors.initials: M
authors.lastname: Hiess
authors.forename: Michael
authors.initials: M
authors.lastname: Schenner
authors.forename: Clemens
authors.initials: C
authors.lastname: Brossner
authors.forename: Paul
authors.initials: P
authors.lastname: Schramek
mesh_terms: D000368:Aged; D015331:Cohort Studies; D006801:Humans; D008197:Lymph Node Excision; D008297:Male; D008875:Middle Aged; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000601:surgery*; D021701:Sentinel Lymph Node Biopsy