title: Anthracene-tethered ruthenium(II) arene complexes as tools to visualize the cellular localization of putative organometallic anticancer compounds.
abstract: Anthracene derivatives of ruthenium(II) arene compounds with 1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane (pta) or a sugar phosphite ligand, viz., 3,5,6-bicyclophosphite-1,2-O-isopropylidene-α-d-glucofuranoside, were prepared in order to evaluate their anticancer properties compared to the parent compounds and to use them as models for intracellular visualization by fluorescence microscopy. Similar IC(50) values were obtained in cell proliferation assays, and similar levels of uptake and accumulation were also established. The X-ray structure of [{Ru(η(6)-C(6)H(5)CH(2)NHCO-anthracene)Cl(2)(pta)] is also reported.
authors.affiliation: Institute of Chemical Sciences and Engineering, Swiss Federal Institute of Technology (EPFL), 1015 Lausanne, Switzerland. alexey.nazarov@epfl.ch
authors.forename: Alexey A
authors.initials: AA
authors.lastname: Nazarov
authors.forename: Julie
authors.initials: J
authors.lastname: Risse
authors.forename: Wee Han
authors.initials: WH
authors.lastname: Ang
authors.forename: Frederic
authors.initials: F
authors.lastname: Schmitt
authors.forename: Olivier
authors.initials: O
authors.lastname: Zava
authors.forename: Albert
authors.initials: A
authors.lastname: Ruggi
authors.forename: Michael
authors.initials: M
authors.lastname: Groessl
authors.forename: Rosario
authors.initials: R
authors.lastname: Scopelitti
authors.forename: Lucienne
authors.initials: L
authors.lastname: Juillerat-Jeanneret
authors.forename: Christian G
authors.initials: CG
authors.lastname: Hartinger
authors.forename: Paul J
authors.initials: PJ
authors.lastname: Dyson
mesh_terms: D000873:Anthracenes / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry*; D006860:Hydrogen Bonding; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D008856:Microscopy, Fluorescence; D008958:Models, Molecular; D009942:Organometallic Compounds / Q000737:chemistry*; D017975:Ruthenium Compounds / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D021241:Spectrometry, Mass, Electrospray Ionization; D014961:X-Ray Diffraction
chemical_list: D000873:Anthracenes; D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D017975:Ruthenium Compounds; C034020:anthracene