title: Regression analysis based on conditional likelihood approach under semi-competing risks data.
abstract: Medical studies often involve semi-competing risks data, which consist of two types of events, namely terminal event and non-terminal event. Because the non-terminal event may be dependently censored by the terminal event, it is not possible to make inference on the non-terminal event without extra assumptions. Therefore, this study assumes that the dependence structure on the non-terminal event and the terminal event follows a copula model, and lets the marginal regression models of the non-terminal event and the terminal event both follow time-varying effect models. This study uses a conditional likelihood approach to estimate the time-varying coefficient of the non-terminal event, and proves the large sample properties of the proposed estimator. Simulation studies show that the proposed estimator performs well. This study also uses the proposed method to analyze AIDS Clinical Trial Group (ACTG 320).
authors.affiliation: Department of Mathematics, National Chung Cheng University, Chia-Yi, Taiwan, R.O.C. jjhsieh@math.ccu.edu.tw
authors.forename: Jin-Jian
authors.initials: JJ
authors.lastname: Hsieh
authors.forename: Yu-Ting
authors.initials: YT
authors.lastname: Huang
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000175:diagnosis / Q000276:immunology; D003198:Computer Simulation; D006678:HIV / Q000276:immunology; D015658:HIV Infections / Q000188:drug therapy / Q000276:immunology; D017320:HIV Protease Inhibitors / Q000627:therapeutic use; D006801:Humans; D019469:Indinavir / Q000627:therapeutic use; D016013:Likelihood Functions; D012044:Regression Analysis; D012306:Risk
chemical_list: D017320:HIV Protease Inhibitors; D019469:Indinavir