title: A review of current methods for assessing hemostasis in vivo and introduction to a potential alternative approach.
abstract: A validated method for assessing hemostasis in vivo is critical for testing the hemostatic efficacy of therapeutic agents in preclinical animal models and in patients with inherited bleeding disorders, such as von Willebrand disease (VWD) and hemophilia A, or with acquired bleeding disorders such as those resulting from medications or disease processes. In this review, we discuss current methods for assessing hemostasis in vivo and the associated challenges. We also present ARFI-Monitored Hemostatic Challenge; a new, potentially alternate method for in vivo hemostasis monitoring that is in development by our group.
authors.affiliation: Joint Department of Biomedical Engineering, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. cmgallip@bme.unc.edu
authors.forename: Mallory R
authors.initials: MR
authors.lastname: Scola
authors.forename: Leslie M
authors.initials: LM
authors.lastname: Baggesen
authors.forename: Tim C
authors.initials: TC
authors.lastname: Nichols
authors.forename: Nigel S
authors.initials: NS
authors.lastname: Key
authors.forename: Caterina M
authors.initials: CM
authors.lastname: Gallippi
mesh_terms: D000818:Animals; D001778:Blood Coagulation Disorders / Q000097:blood* / Q000000981:diagnostic imaging / Q000628:therapy; D004195:Disease Models, Animal; D004285:Dogs; D006467:Hemophilia A / Q000097:blood / Q000000981:diagnostic imaging / Q000628:therapy; D006487:Hemostasis / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D014463:Ultrasonography; D014842:von Willebrand Diseases / Q000097:blood / Q000000981:diagnostic imaging / Q000628:therapy