title: Continuous intravenous infusion of ketamine and lidocaine as adjuvant analgesics in a 5-year-old patient with neuropathic cancer pain.
abstract: For difficult to treat neuropathic pain from cancer, adjuvant analgesics are often used with opioids. We present the case of a 5-year-old girl who was diagnosed with meningitis caused by malignant T-cell lymphoma. She had severe neuropathic pain not relieved by increasing doses of a fentanyl infusion. Intravenous administration of ketamine and lidocaine in combination with fentanyl provided excellent analgesia without significant side effects. Ketamine and lidocaine can be safely infused together with concomitant opioids for the treatment of refractory neuropathic pain caused by cancer.
authors.affiliation: Department of Pediatrics, Graduate School of Biomedical Sciences, Hiroshima University, Hiroshima, Japan. kajiume@hiroshima-u.ac.jp
authors.forename: Teruyuki
authors.initials: T
authors.lastname: Kajiume
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Sera
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Nakanuno
authors.forename: Taemi
authors.initials: T
authors.lastname: Ogura
authors.forename: Shuhei
authors.initials: S
authors.lastname: Karakawa
authors.forename: Makoto
authors.initials: M
authors.lastname: Kobayakawa
authors.forename: Shima
authors.initials: S
authors.lastname: Taguchi
authors.forename: Kyoko
authors.initials: K
authors.lastname: Oshita
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kawaguchi
authors.forename: Takashi
authors.initials: T
authors.lastname: Sato
authors.forename: Masao
authors.initials: M
authors.lastname: Kobayashi
mesh_terms: D000700:Analgesics / Q000008:administration & dosage*; D000779:Anesthetics, Local / Q000008:administration & dosage* / Q000627:therapeutic use*; D002675:Child, Preschool; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007564:Japan; D007649:Ketamine / Q000008:administration & dosage*; D008012:Lidocaine / Q000627:therapeutic use; D009437:Neuralgia / Q000188:drug therapy*; D059408:Pain Management / Q000379:methods; D010148:Intractable Pain / Q000188:drug therapy* / Q000209:etiology
chemical_list: D000700:Analgesics; D000779:Anesthetics, Local; D007649:Ketamine; D008012:Lidocaine