title: Hormonal therapy in breast cancer: a model disease for the personalization of cancer care.
abstract: The treatment of breast cancer is driven by subtype classification, of which the assessment of hormone receptor status is one of the important determinants of therapy. The use of hormonal therapy to treat estrogen-receptor positive breast cancer has been studied for over a century and is one of the well-described uses of personalized medicine. In this review, we will describe the classification of hormone receptor status and the various endocrine treatment strategies. Opportunities for personalization of care are illustrated.
authors.affiliation: University of Pittsburgh Cancer Institute and UPMC Cancer Centers, UPMC Cancer Pavillon, Pittsburgh, PA 15232, USA. puhallasl@upmc.edu
authors.forename: Shannon
authors.initials: S
authors.lastname: Puhalla
authors.forename: Saveri
authors.initials: S
authors.lastname: Bhattacharya
authors.forename: Nancy E
authors.initials: NE
authors.lastname: Davidson
mesh_terms: D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D006801:Humans; D057285:Precision Medicine; D017697:Premenopause; D011960:Receptors, Estrogen / Q000378:metabolism
chemical_list: D018931:Antineoplastic Agents, Hormonal; D011960:Receptors, Estrogen