title: Plasma and synovial fluid connective tissue growth factor levels are correlated with disease severity in patients with knee osteoarthritis.
abstract: BACKGROUND
  Connective tissue growth factor (CTGF) has been implicated in development of osteoarthritis (OA).
  
  
  OBJECTIVE
  To determine the correlation between plasma and synovial fluid CTGF levels and the severity in knee osteoarthritis patients.
  
  
  METHODS
  A total of 100 subjects were recruited into this study (75 OA patients and 25 controls). CTGF concentrations in plasma and synovial fluid were analyzed by enzyme-linked immunosorbent assay.
  
  
  RESULTS
  Plasma and synovial fluid CTGF concentrations were correlated with radiographic severity. There was a positive correlation between plasma and synovial fluid CTGF levels.
  
  
  CONCLUSIONS
  CTGF could be useful for monitoring the severity and progression of OA.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross Society, Bangkok, Thailand. Sittisak.H@chula.ac.th
authors.forename: Sittisak
authors.initials: S
authors.lastname: Honsawek
authors.forename: Pongsak
authors.initials: P
authors.lastname: Yuktanandana
authors.forename: Aree
authors.initials: A
authors.lastname: Tanavalee
authors.forename: Chintana
authors.initials: C
authors.lastname: Chirathaworn
authors.forename: Wilai
authors.initials: W
authors.lastname: Anomasiri
authors.forename: Wanvisa
authors.initials: W
authors.lastname: Udomsinprasert
authors.forename: Natthaphon
authors.initials: N
authors.lastname: Saetan
authors.forename: Tanyawan
authors.initials: T
authors.lastname: Suantawee
authors.forename: Saran
authors.initials: S
authors.lastname: Tantavisut
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D055513:Connective Tissue Growth Factor / Q000097:blood* / Q000378:metabolism; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007719:Knee Joint / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D020370:Osteoarthritis, Knee / Q000097:blood* / Q000000981:diagnostic imaging / Q000473:pathology; D011859:Radiography; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D013582:Synovial Fluid / Q000378:metabolism*
chemical_list: D055513:Connective Tissue Growth Factor