title: Ménétrier disease and gastric adenocarcinoma in 3 Cairn terrier littermates.
abstract: Ménétrier disease is a rare hypertrophic gastropathy that is characterized by hyperplasia of the mucous cells with concurrent loss of chief and parietal cells within the gastric glands. There are few reports of this disease in dogs, and little is known about the clinical presentation and progression of canine Ménétrier disease. Three Cairn terrier littermates developed hypertrophic gastropathy with histological features of Ménétrier disease. One dog remained clinically asymptomatic for 2 years after diagnosis. The development of this disease in 3 siblings suggests a possible inherited predisposition. All 3 dogs also developed gastric neoplasia, which has been reported in human Ménétrier disease but has not been associated previously with hypertrophic gastropathy in domestic species.
authors.affiliation: Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Private Bag 11 222, Palmerston North, New Zealand. J.Munday@massey.ac.nz
authors.forename: J S
authors.initials: JS
authors.lastname: Munday
authors.forename: D
authors.initials: D
authors.lastname: Aberdein
authors.forename: G D
authors.initials: GD
authors.lastname: Cullen
authors.forename: A F
authors.initials: AF
authors.lastname: French
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D005758:Gastritis, Hypertrophic / Q000473:pathology / Q000662:veterinary*; D006965:Hyperplasia / Q000473:pathology / Q000662:veterinary; D008297:Male; D013274:Stomach Neoplasms / Q000473:pathology / Q000662:veterinary*