title: Structure elucidation of indole-indoline type alkaloids: a retrospective account from the point of view of current NMR and MS technology.
abstract: In this review our aim is to look back on how the structure elucidation of bisindoles, especially with focus placed on vinblastine and vincristine analogues, has evolved alongside with the development of MS and NMR over the last 60 years from the perspective of our present-day use of state-of-the-art MS and NMR instrumentation and on the basis of our own accumulated views and experience in the field.
authors.affiliation: Chemical Works of Gedeon Richter Plc., API Research and Development-Spectroscopic Research, H-1475 Budapest 10, P.O.B. 27, Hungary.
authors.forename: Zoltán
authors.initials: Z
authors.lastname: Béni
authors.forename: Viktor
authors.initials: V
authors.lastname: Háda
authors.forename: Zsófia
authors.initials: Z
authors.lastname: Dubrovay
authors.forename: Csaba
authors.initials: C
authors.lastname: Szántay
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000379:methods; D006801:Humans; D026121:Indole Alkaloids / Q000032:analysis* / Q000737:chemistry; D007211:Indoles / Q000032:analysis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D013058:Mass Spectrometry / Q000379:methods*; D008956:Models, Chemical; D015394:Molecular Structure; D010936:Plant Extracts / Q000032:analysis; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods; D013678:Technology, Pharmaceutical / Q000379:methods; D014747:Vinblastine / Q000032:analysis; D014748:Vinca Alkaloids / Q000737:chemistry; D014750:Vincristine / Q000032:analysis
chemical_list: D026121:Indole Alkaloids; D007211:Indoles; D010936:Plant Extracts; D014748:Vinca Alkaloids; D014750:Vincristine; D014747:Vinblastine; C057812:indoline