title: [Current trends in liver biopsy indications in chronic liver diseases].
abstract: Liver biopsy (LB) remains a major tool in chronic liver disease evaluation. Main current indications of LB in chronic liver disease are reviewed in this manuscript. Major development of non-invasive tools for evaluation of liver fibrosis led to decrease of LB indications in patients with chronic hepatitis C. LB is the only tool for exploration of necroinflammatory and fibrosis lesions in chronic hepatitis B as well as in autoimmune hepatitis. LB is the sole exam that can differentiate between bland steatosis and steatohepatitis in the setting of metabolic syndrome and to confirm the diagnosis of alcoholic hepatitis when corticosteroids are indicated.
authors.affiliation: Centre hospitalier Laënnec, service d'hépatogastroentérologie et de nutrition, 60100 Creil, France. jfrancois.cadranel@ch-creil.fr
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Cadranel
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Nousbaum
mesh_terms: D001707:Biopsy, Needle / Q000379:methods / Q000592:standards*; D002908:Chronic Disease; D000075202:Contraindications; D003937:Diagnosis, Differential; D005234:Fatty Liver / Q000473:pathology; D006432:Hemochromatosis / Q000235:genetics / Q000473:pathology; D019694:Hepatitis B, Chronic / Q000473:pathology; D019698:Hepatitis C, Chronic / Q000473:pathology; D006519:Hepatitis, Alcoholic / Q000473:pathology; D019693:Hepatitis, Autoimmune / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology*; D008103:Liver Cirrhosis / Q000473:pathology; D008107:Liver Diseases / Q000473:pathology*; D024821:Metabolic Syndrome / Q000473:pathology