title: Regulatory mechanisms of the plasma contact system.
abstract: The plasma contact system is a proinflammatory and procoagulant protease system. The biochemistry of the system is well established, however, its biological functions are just beginning to emerge. Here, we provide a condensed overview on mechanisms involved in activation and regulation of the contact system. These recent findings will help us to better understand the role of the enigmatic system for health and disease.
authors.affiliation: Department for Clinical Chemistry and Haematology, University Medical Center Utrecht, Utrecht, the Netherlands.
authors.forename: Coen
authors.initials: C
authors.lastname: Maas
authors.forename: Thomas
authors.initials: T
authors.lastname: Renné
mesh_terms: D000818:Animals; D001777:Blood Coagulation / Q000502:physiology*; D005174:Factor XII / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000097:blood; D016234:Kallikrein-Kinin System / Q000502:physiology*; D019679:Kininogen, High-Molecular-Weight / Q000378:metabolism; D011288:Prekallikrein / Q000378:metabolism
chemical_list: D019679:Kininogen, High-Molecular-Weight; D005174:Factor XII; D011288:Prekallikrein