title: [Diclofenac induced liver injuries].
abstract: We report the case of an 83-year-old female patient who developed diclofenac-associated liver injury nine days after therapy had started. Diclofenac was used to treat back pain associated with an acute exacerbation of a chronic lumbovertebral symptoms reversed. We discuss the adverse reaction profile of diclofenac, particularly diclofenac-induced liver injury. We also discuss the epidemiology, clinical presentation and mechanisms of NSAID-induced liver injury, as well as risk factors and preventive measures.
authors.affiliation: Abteilung für Klinische Pharmakologie und Toxikologie und Regionales Pharmacovigilance-Zentrum Basel.
authors.forename: L
authors.initials: L
authors.lastname: Nezic
authors.forename: S
authors.initials: S
authors.lastname: Krähenbühl
authors.forename: A E
authors.initials: AE
authors.lastname: Rätz Bravo
mesh_terms: D000369:Aged, 80 and over; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000517:prevention & control; D003430:Cross-Sectional Studies; D003937:Diagnosis, Differential; D004008:Diclofenac / Q000009:adverse effects* / Q000627:therapeutic use; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008111:Liver Function Tests; D012307:Risk Factors; D055009:Spondylosis / Q000188:drug therapy*; D013557:Switzerland
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac