title: Synthesis, resolution and anticonvulsant activity of chiral N-1'-ethyl,N-3'-(1-phenylethyl)-(R,S)-2'H,3H,5'H-spiro-(2-benzofuran-1,4'-imidazolidine)-2',3,5'-trione diastereomers.
abstract: Four new N-1',N-3'-disubstituted-2'H,3H,5'H-spiro-(2-benzofuran-1,4'-imidazolidine)-2',3,5'-triones bearing a chiral N-3' substituent were synthesized, resolved and their anticonvulsant activity was obtained and determined that the activity was not stereoselective.
authors.affiliation: Department of Pharmaceutical Sciences, St. John's University, 8000 Utopia Parkway, Jamaica, NY 11439, USA.
authors.forename: Ishwar R
authors.initials: IR
authors.lastname: Sadarangani
authors.forename: Souful
authors.initials: S
authors.lastname: Bhatia
authors.forename: Daniel
authors.initials: D
authors.lastname: Amarante
authors.forename: Istvan
authors.initials: I
authors.lastname: Lengyel
authors.forename: Ralph A
authors.initials: RA
authors.lastname: Stephani
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000627:therapeutic use; D001572:Benzofurans / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000627:therapeutic use; D006801:Humans; D048289:Imidazolidines / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000627:therapeutic use; D051379:Mice; D010433:Pentylenetetrazole / Q000008:administration & dosage / Q000009:adverse effects; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy; D013141:Spiro Compounds / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000627:therapeutic use; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D000927:Anticonvulsants; D001572:Benzofurans; D048289:Imidazolidines; D013141:Spiro Compounds; D010433:Pentylenetetrazole