title: Maternal mumps antibodies in a cohort of children up to the age of 1 year.
abstract: The duration of the presence of maternal mumps antibodies in a prospective cohort study is presented. Immunoglobulin G against mumps was portioned with a commercial ELISA test (Euroimmun® anti-mumps Virus AT ELISA, Germany) on samples from 213 mother-child pairs at seven time points between pregnancy and 12 months of age. Non-linear mixed models were used to model maternal antibody decay in infants. The model-based median time to loss of antibodies was 3.6 months. The median child-specific time to loss of antibodies in children of naturally immune women (3.8 months) and children of vaccinated women (2.4 months) differed significantly (p = 0.025). The log antibody level of the mother and the log birth weight were correlated with the duration of maternal antibodies in infants (p < 0.0001).
  
  
  CONCLUSIONS
  Children of vaccinated women loose maternal mumps antibodies significantly earlier in life compared to children of naturally infected women. If early administration (<12 months) of the combined measles, mumps, and rubella vaccine is needed, maternal mumps antibodies are not expected to interfere with infant humoral vaccine responses.
authors.affiliation: Centre for the Evaluation of Vaccination, Vaccine and Infectious Disease Institute, WHO Collaborating Centre for Control and Prevention of Infectious Diseases, University of Antwerp, UA-CDE-R 2.13, Universiteitsplein 1, 2610 Wilrijk, Antwerp, Belgium. elke.leuridan@ua.ac.be
authors.forename: E
authors.initials: E
authors.lastname: Leuridan
authors.forename: N
authors.initials: N
authors.lastname: Goeyvaerts
authors.forename: N
authors.initials: N
authors.lastname: Hens
authors.forename: V
authors.initials: V
authors.lastname: Hutse
authors.forename: P
authors.initials: P
authors.lastname: Van Damme
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D015331:Cohort Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007112:Immunity, Maternally-Acquired; D007074:Immunoglobulin G / Q000097:blood*; D007223:Infant; D007231:Infant, Newborn; D022542:Measles-Mumps-Rubella Vaccine / Q000276:immunology*; D015233:Models, Statistical; D009109:Mumps virus / Q000276:immunology*; D011247:Pregnancy; D011446:Prospective Studies; D013997:Time Factors; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D015415:Biomarkers; D007074:Immunoglobulin G; D022542:Measles-Mumps-Rubella Vaccine