title: Head and neck cancer with lower neck nodal metastases: management of 23 cases and review of the literature.
abstract: To investigate the patient outcomes associated with the applied modes of therapy in head and neck cancer with lower neck nodal metastases. The medical records of 23 consecutive individuals who were managed by intent to treat for head and neck cancer with metastatic disease in the lower neck nodes over a 19-year period were reviewed. The mean age was 53.5 years, and the larynx was the most frequently affected primary site (57%). Overall, locoregional tumor control was achieved in the majority (75%) of the cases and the 2-year survival rate was 48%. The 2-year survival rates of people managed by surgery and postoperative radiotherapy, chemoradiation or single modality therapy were 63%, 56% and 17%, respectively, (p=0.04). Aggressive therapy resulted in five (22%) long-term (>5 years) survivors. The combination of treatment modalities proved to be effective management for head and neck cancer with lower neck nodal metastases and should be further investigated in prospective trials.
authors.affiliation: Department of Radiology, Louisiana State University Health Sciences Center and Feist-Weiller Cancer Center, Shreveport, LA 71130, USA. fampil@lsuhsc.edu
authors.forename: Federico L
authors.initials: FL
authors.lastname: Ampil
authors.forename: Cherie-Ann O
authors.initials: CA
authors.lastname: Nathan
authors.forename: Guillermo
authors.initials: G
authors.lastname: Sangster
authors.forename: Gloria
authors.initials: G
authors.lastname: Caldito
mesh_terms: D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D005260:Female; D006258:Head and Neck Neoplasms / Q000401:mortality* / Q000628:therapy; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009333:Neck; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome