title: Non-canonical Notch signaling: emerging role and mechanism.
abstract: Notch is an ancient transmembrane receptor with crucial roles in cell-fate choices. Although the 'canonical' Notch pathway and its core members are well established - involving ligand-induced cleavage of Notch for transcriptional regulation - it has been unclear whether Notch can also function independently of ligand and transcription ('non-canonically') through a common mechanism. Recent studies suggest that Notch can non-canonically exert its biological functions by post-translationally targeting Wnt/β-catenin signaling, an important cellular and developmental regulator. The non-canonical Notch pathway appears to be highly conserved from flies to mammals. Here, we discuss the emerging conserved mechanism and role of ligand/transcription-independent Notch signaling in cell and developmental biology.
authors.affiliation: Division of Cardiology, Department of Medicine, Johns Hopkins University, 720 Rutland Avenue, Baltimore, MD 21205, USA.
authors.forename: Peter
authors.initials: P
authors.lastname: Andersen
authors.forename: Hideki
authors.initials: H
authors.lastname: Uosaki
authors.forename: Lincoln T
authors.initials: LT
authors.lastname: Shenje
authors.forename: Chulan
authors.initials: C
authors.lastname: Kwon
mesh_terms: D000818:Animals; D006801:Humans; D008954:Models, Biological; D051880:Receptors, Notch / Q000378:metabolism; D015398:Signal Transduction; D051153:Wnt Proteins / Q000378:metabolism; D051176:beta Catenin / Q000378:metabolism
chemical_list: D051880:Receptors, Notch; D051153:Wnt Proteins; D051176:beta Catenin