title: International variation in prostate cancer incidence and mortality rates.
abstract: BACKGROUND
  Wide variation exists internationally for prostate cancer (PCa) rates due to differences in detection practices, treatment, and lifestyle and genetic factors.
  
  
  OBJECTIVE
  We present contemporary variations in PCa incidence and mortality patterns across five continents using the most recent data from the International Agency for Research on Cancer.
  
  
  METHODS
  PCa incidence and mortality estimates for 2008 from GLOBOCAN are presented. We also examine recent trends in PCa incidence rates for 40 countries and mortality rates for 53 countries from 1985 and onward via join-point analyses using an augmented version of Cancer Incidence in Five Continents and the World Health Organization mortality database.
  
  
  RESULTS
  Estimated PCa incidence rates remain most elevated in the highest resource counties worldwide including North America, Oceania, and western and northern Europe. Mortality rates tend to be higher in less developed regions of the world including parts of South America, the Caribbean, and sub-Saharan Africa. Increasing PCa incidence rates during the most recent decade were observed in 32 of the 40 countries examined, whereas trends tended to stabilize in 8 countries. In contrast, PCa mortality rates decreased in 27 of the 53 countries under study, whereas rates increased in 16 and remained stable in 10 countries.
  
  
  CONCLUSIONS
  PCa incidence rates increased in nearly all countries considered in this analysis except in a few high-income countries. In contrast, the increase in PCa mortality rates mainly occurred in lower resource settings, with declines largely confined to high-resource countries.
authors.affiliation: Intramural Research, American Cancer Society, Atlanta, GA 30303-1002, USA.
authors.forename: Melissa M
authors.initials: MM
authors.lastname: Center
authors.forename: Ahmedin
authors.initials: A
authors.lastname: Jemal
authors.forename: Joannie
authors.initials: J
authors.lastname: Lortet-Tieulent
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Ward
authors.forename: Jacques
authors.initials: J
authors.lastname: Ferlay
authors.forename: Otis
authors.initials: O
authors.lastname: Brawley
authors.forename: Freddie
authors.initials: F
authors.lastname: Bray
mesh_terms: D000349:Africa / Q000453:epidemiology; D001208:Asia / Q000453:epidemiology; D003906:Developing Countries / Q000191:economics / Q000706:statistics & numerical data*; D004813:Epidemiology / Q000639:trends; D005060:Europe / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D009656:North America / Q000453:epidemiology; D044349:Oceania / Q000453:epidemiology; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000191:economics / Q000453:epidemiology* / Q000401:mortality / Q000628:therapy; D012042:Registries; D013020:South America / Q000453:epidemiology; D013997:Time Factors