title: Intrapartum fetal heart rate characteristics of nonanomalous fetuses with trisomy 21.
abstract: OBJECTIVE
  To compare the intrapartum fetal heart rate (FHR) characteristics and selected birth outcomes of nonanomalous trisomy 21 (T21) fetuses to matched controls.
  
  
  METHODS
  Nonanomalous, non-growth-restricted T21 infants were identified and matched by gestational age to presumed euploid controls. We excluded women with scheduled cesarean deliveries and multiple gestations. The incidence of abnormal FHR patterns within 3 hours of delivery and birth outcomes were compared between T21 fetuses and controls. The presence of any abnormal FHR pattern was the primary outcome. Birth outcomes included 5-minute Apgar <7, neonatal intensive care unit admission, and cesarean delivery for fetal indications.
  
  
  RESULTS
  Forty-four T21 infants and 44 controls were compared. Of the T21 infants, 83% were postnatally diagnosed. No significant differences were noted in the primary outcome (68% versus 59%, p = 0.37) or birth outcomes.
  
  
  CONCLUSIONS
  T21 is not associated with an increased incidence of abnormal FHR patterns or adverse birth outcomes compared with presumed euploid fetuses.
authors.affiliation: Division of Maternal Fetal Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA. koduri657@gmail.com
authors.forename: Priyadarshini
authors.initials: P
authors.lastname: Koduri
authors.forename: Maria
authors.initials: M
authors.lastname: Giraldo
authors.forename: Philip
authors.initials: P
authors.lastname: Shlossman
authors.forename: Anthony
authors.initials: A
authors.lastname: Sciscione
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Berghella
authors.forename: Suneet P
authors.initials: SP
authors.lastname: Chauhan
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D002585:Cesarean Section; D004314:Down Syndrome / Q000503:physiopathology*; D005260:Female; D005333:Fetus / Q000502:physiology*; D005865:Gestational Age; D006340:Heart Rate, Fetal / Q000502:physiology*; D006801:Humans; D007223:Infant; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies