title: Catalytic enantiospecific [3+2] annulation of aminocyclopropanes with ketones.
abstract: An almost familiar ring: The first enantiospecific [3+2] annulation of donor-acceptor aminocyclopropanes with ketones is reported (see scheme; Phth=phthaloyl). The reaction is catalysed by tin(IV) chloride (5 mol %) at -78 °C and gives aminotetrahydrofurans bearing a quaternary C5 atom in high yield, diastereoselectivity and enantiospecificity (see scheme).
authors.affiliation: Laboratory of Catalysis and Organic Synthesis, Ecole Polytechnique Fédérale de Lausanne, EPFL SB ISIC LCSO, BCH 4306, 1015 Lausanne, Switzerland.
authors.forename: Fides
authors.initials: F
authors.lastname: Benfatti
authors.forename: Florian
authors.initials: F
authors.lastname: de Nanteuil
authors.forename: Jérôme
authors.initials: J
authors.lastname: Waser