title: Coordinated events: FGF signaling and other related pathways in palatogenesis.
abstract: Cleft palate is a common craniofacial anomaly that is costly to both patients and the health care system. Investigation of each stage of palate development enhances understanding of this anomaly. Although the exact molecular signaling mechanisms that contribute to palatogenesis remain elusive, multiple pathways, such as fibroblast growth factor (FGF) signaling, have been recognized as important contributors. Alterations in FGF signaling have previously been implicated in palatal clefting. The current review discusses FGF signaling and the major signaling mediators affecting FGF signaling during each stage of palatogenesis.
authors.affiliation: Division of Plastic Surgery, Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri, USA.
authors.forename: Alison K
authors.initials: AK
authors.lastname: Snyder-Warwick
authors.forename: Chad A
authors.initials: CA
authors.lastname: Perlyn
mesh_terms: D000818:Animals; D019485:Bone Morphogenetic Proteins / Q000378:metabolism; D002972:Cleft Palate / Q000196:embryology* / Q000235:genetics / Q000378:metabolism*; D005346:Fibroblast Growth Factors / Q000378:metabolism*; D053823:Hedgehog Proteins / Q000378:metabolism; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000378:metabolism; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D051379:Mice; D009154:Mutation; D010641:Phenotype; D015398:Signal Transduction; D015534:Trans-Activators / Q000378:metabolism
chemical_list: D019485:Bone Morphogenetic Proteins; D053823:Hedgehog Proteins; D036341:Intercellular Signaling Peptides and Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; C509239:SHH protein, human; D015534:Trans-Activators; D005346:Fibroblast Growth Factors