title: Time-dependent changes of myeloperoxidase in relation to in-hospital mortality in patients with the first anterior ST-segment elevation myocardial infarction treated by primary percutaneous coronary intervention.
abstract: OBJECTIVE
  To analyze the prognostic value of myeloperoxidase (MPO) in relation to in-hospital mortality and to identify the optimum time point for sampling in patients with the first anterior ST-segment elevation myocardial infarction (STEMI) treated by primary percutaneous coronary intervention (pPCI).
  
  
  METHODS
  A total of 100 consecutive patients with the first anterior STEMI undergoing pPCI were included. Blood samples were collected at baseline, 4, 8, 12, 18, 24, 48 and 168 hours (h) after pPCI.
  
  
  RESULTS
  MPO concentrations have showed a biphasic pattern over time; the highest MPO levels were at4h and 24h after pPCI. In-hospital mortality was 6%. MPO at 24h significantly correlated with troponin I as well as heart failure. After multivariate adjustment, MPO at 24h was an independent predictor of the in-hospital mortality (OR 3.34, 95% CI 1.13-9.86, P=0.029).
  
  
  CONCLUSIONS
  In patients with the first anterior STEMI treated by pPCI, MPO at 24h after procedure was an independent predictor of the in-hospital mortality.
authors.affiliation: Center for Medical Biochemistry, School of Pharmacy University of Belgrade, Clinical Center of Serbia, Visegradska 26, 11000 Belgrade, Serbia. sanjast@eunet.rs
authors.forename: Sanja
authors.initials: S
authors.lastname: Stankovic
authors.forename: Milika
authors.initials: M
authors.lastname: Asanin
authors.forename: Danijela
authors.initials: D
authors.lastname: Trifunovic
authors.forename: Nada
authors.initials: N
authors.lastname: Majkic-Singh
authors.forename: Svetlana
authors.initials: S
authors.lastname: Ignjatovic
authors.forename: Igor
authors.initials: I
authors.lastname: Mrdovic
authors.forename: Dragan
authors.initials: D
authors.lastname: Matic
authors.forename: Lidija
authors.initials: L
authors.lastname: Savic
authors.forename: Jelena
authors.initials: J
authors.lastname: Marinkovic
authors.forename: Miodrag
authors.initials: M
authors.lastname: Ostojic
authors.forename: Zorana
authors.initials: Z
authors.lastname: Vasiljevic
mesh_terms: D000368:Aged; D017130:Angioplasty / Q000379:methods; D015906:Angioplasty, Balloon, Coronary; D001241:Aspirin / Q000008:administration & dosage / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D001774:Blood Chemical Analysis; D000077144:Clopidogrel; D017023:Coronary Angiography; D005260:Female; D006333:Heart Failure; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000201:enzymology / Q000401:mortality* / Q000628:therapy*; D009195:Peroxidase / Q000097:blood* / Q000378:metabolism; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012372:ROC Curve; D013988:Ticlopidine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use; D013997:Time Factors; D019210:Troponin I / Q000378:metabolism
chemical_list: D015415:Biomarkers; D019210:Troponin I; D000077144:Clopidogrel; D009195:Peroxidase; D013988:Ticlopidine; D001241:Aspirin