title: Understanding the neural mechanisms involved in sensory control of voice production.
abstract: Auditory feedback is important for the control of voice fundamental frequency (F0). In the present study we used neuroimaging to identify regions of the brain responsible for sensory control of the voice. We used a pitch-shift paradigm where subjects respond to an alteration, or shift, of voice pitch auditory feedback with a reflexive change in F0. To determine the neural substrates involved in these audio-vocal responses, subjects underwent fMRI scanning while vocalizing with or without pitch-shifted feedback. The comparison of shifted and unshifted vocalization revealed activation bilaterally in the superior temporal gyrus (STG) in response to the pitch shifted feedback. We hypothesize that the STG activity is related to error detection by auditory error cells located in the superior temporal cortex and efference copy mechanisms whereby this region is responsible for the coding of a mismatch between actual and predicted voice F0.
authors.affiliation: Research Imaging Institute, University of Texas Health Science Center San Antonio, San Antonio, TX 78229, USA. Parkinson@uthscsa.edu
authors.forename: Amy L
authors.initials: AL
authors.lastname: Parkinson
authors.forename: Sabina G
authors.initials: SG
authors.lastname: Flagmeier
authors.forename: Jordan L
authors.initials: JL
authors.lastname: Manes
authors.forename: Charles R
authors.initials: CR
authors.lastname: Larson
authors.forename: Bill
authors.initials: B
authors.lastname: Rogers
authors.forename: Donald A
authors.initials: DA
authors.lastname: Robin
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D000465:Algorithms; D001303:Auditory Cortex / Q000502:physiology; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000502:physiology; D003627:Data Interpretation, Statistical; D056228:Feedback, Sensory; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007821:Laryngeal Muscles / Q000294:innervation / Q000502:physiology; D008279:Magnetic Resonance Imaging; D008297:Male; D009434:Neural Pathways / Q000502:physiology; D010100:Oxygen / Q000097:blood; D010898:Pitch Perception / Q000502:physiology; D012677:Sensation / Q000502:physiology*; D013702:Temporal Lobe / Q000502:physiology; D014831:Voice / Q000502:physiology*; D055815:Young Adult
chemical_list: D010100:Oxygen