title: A new eudesmane sesquiterpene glycosides from Liriope muscari.
abstract: A new eudesmane sesquiterpene glycoside, ophiopogonoside B (1), along with five known compounds, ophiopogonoside A (2), ruscogenin-1-O-[β-D-glucopyranosyl (1 → 2)]-[β-D-xylopyranosyl (1 → 3)]-β-D-fucopyranoside (3), palmitic acid (4), palmitic acid glyceride (5), and β-sitosterol-D-glucopyranoside (6),was isolated from the tuberous roots of Liriope muscari (Decn.) Bailey (Liliaceae). Their structures were confirmed by 1D and 2D NMR spectroscopy. Among them, compounds 1, 2, 4, and 5 were the first reported from the genus Liriope. Ophiopogonoside B (1) showed moderate inhibitory activity to glycogen phosphorylase a.
authors.affiliation: Department of Resources Science of Traditional Chinese Medicines, China Pharmaceutical University, Nanjing, 210009, China.
authors.forename: Chang
authors.initials: C
authors.lastname: Jiang
authors.forename: Zhi-Hua
authors.initials: ZH
authors.lastname: Liu
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Bin-Bin
authors.initials: BB
authors.lastname: Lin
authors.forename: Fan
authors.initials: F
authors.lastname: Yang
authors.forename: Min-Jian
authors.initials: MJ
authors.lastname: Qin
mesh_terms: D000465:Algorithms; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D024981:Glycogen Phosphorylase / Q000187:drug effects* / Q000378:metabolism; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031424:Liriope Plant / Q000737:chemistry*; D008099:Liver / Q000201:enzymology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D011817:Rabbits; D045787:Sesquiterpenes, Eudesmane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism
chemical_list: D004365:Drugs, Chinese Herbal; D006027:Glycosides; D045787:Sesquiterpenes, Eudesmane; C573379:ophiopogonoside B; D024981:Glycogen Phosphorylase