title: Schizophrenia genetics: progress, at last.
abstract: The heritability of schizophrenia is well established, and has motivated the search for genetic variation that contributes to susceptibility. Recent progress from both genome-wide association and copy number variant studies have identified risk loci, however, these are at very different ends of the susceptibility spectrum with respect to allele frequency and effect size. It is likely that investigations of common variants have surrendered their full yield, but rare variant exploration is at the very beginning.
authors.affiliation: Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, United States. jmulle@emory.edu
authors.forename: Jennifer Gladys
authors.initials: JG
authors.lastname: Mulle
mesh_terms: D000483:Alleles; D002872:Chromosome Deletion; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics / Q000378:metabolism; D056915:DNA Copy Number Variations; D004198:Disease Susceptibility / Q000378:metabolism / Q000473:pathology; D005787:Gene Frequency; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D015894:Genome, Human; D055106:Genome-Wide Association Study / Q000379:methods; D006801:Humans; D040582:Inheritance Patterns; D012307:Risk Factors; D012559:Schizophrenia / Q000235:genetics* / Q000378:metabolism; D014178:Translocation, Genetic