title: Association of body mass index with exercise cardiopulmonary responses in lung function-matched patients with chronic obstructive pulmonary disease.
abstract: OBJECTIVE
  Lung function is traditionally used to define the severity of chronic obstructive pulmonary disease (COPD). However, this does not exclude other factors. This study investigated the influence of body mass index (BMI) on exercise responses and quality of life in patients with COPD matched for values of forced expiratory volume in 1 second (FEV(1)).
  
  
  METHODS
  Underweight, normal-weight, and overweight patients with COPD, matched for FEV(1), were studied. All patients were evaluated by spirometry, a cardiopulmonary exercise test, respiratory muscle strength, and, St. George's Respiratory Questionnaire (SGRQ).
  
  
  RESULTS
  The baseline characteristics and mean FEV(1) of the 3 groups were similar (P > .05). Respiratory muscle strengths and SGRQ scores were lowest in underweight patients (P < .05). In terms of exercise response, the lowest oxygen uptake at anaerobic threshold and peak exercise, the highest ventilatory equivalent, and the lowest oxygen pulse were evident in underweight patients (P < .05).
  
  
  CONCLUSIONS
  Underweight patients with COPD had lower respiratory muscle strength, impaired exercise capacity, earlier anaerobic metabolism, ineffective ventilation, and poorer quality of life.
authors.affiliation: Division of Pulmonary Medicine, Buddhist Tzu-Chi General Hospital, Taipei Branch, Xindian City, Taipei, Taiwan, Republic of China.
authors.forename: Chou-Chin
authors.initials: CC
authors.lastname: Lan
authors.forename: Chiu-Ping
authors.initials: CP
authors.lastname: Su
authors.forename: Lih-Lih
authors.initials: LL
authors.lastname: Chou
authors.forename: Mei-Chen
authors.initials: MC
authors.lastname: Yang
authors.forename: Chor-Shen
authors.initials: CS
authors.lastname: Lim
authors.forename: Yao-Kuang
authors.initials: YK
authors.lastname: Wu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015308:Anaerobic Threshold; D000886:Anthropometry; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology; D005080:Exercise Test; D005260:Female; D005541:Forced Expiratory Volume; D006304:Health Status; D006801:Humans; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption; D029424:Pulmonary Disease, Chronic Obstructive / Q000503:physiopathology*; D011788:Quality of Life; D012132:Respiratory Muscles / Q000503:physiopathology; D013147:Spirometry