title: Modular synthesis of optically active lactones by Ru-catalyzed asymmetric allylic carboxylation and ring-closing metathesis reaction.
abstract: A new synthetic route to optically active unsaturated γ- and δ-lactones has been demonstrated via asymmetric allylic carboxylation with a planar-chiral Cp'Ru catalyst and ring-closing metathesis reaction with a Grubbs II catalyst, and successfully applied to the enantioselective synthesis of (R)-(-)-massoialactone.
authors.affiliation: Department of Macromolecular Science, Graduate School of Science, Osaka University, Machikaneyama 1-1, Toyonaka, Osaka 560-0043, Japan.
authors.forename: Koichiro
authors.initials: K
authors.lastname: Takii
authors.forename: Naoya
authors.initials: N
authors.lastname: Kanbayashi
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Onitsuka
mesh_terms: D002384:Catalysis; D003500:Cyclization; D007783:Lactones / Q000138:chemical synthesis* / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D007783:Lactones; D012428:Ruthenium