title: Polymorphism of HMGA1 is associated with increased risk of type 2 diabetes among Chinese individuals.
abstract: OBJECTIVE
  Variants of the high-mobility group A1 (HMGA1) gene have been shown to be associated with insulin resistance and type 2 diabetes in individuals of European origin. We aimed to determine whether this locus confers significant susceptibility to type 2 diabetes in the Han Chinese population, and thus cross-race susceptibility to type 2 diabetes.
  
  
  METHODS
  Polymorphisms in HMGA1 were identified by direct sequencing of genomic DNA derived from 192 Chinese participants (96 patients with type 2 diabetes and 96 controls). We then genotyped the common variant IVS5-13insC (c.136-14_136-13insC) in two other independent cohorts, including a total of 2,533 cases and 2,643 ethnically matched controls.
  
  
  RESULTS
  We confirmed the association of the HMGA1 variant IVS5-13insC (c.136-14_136-13insC) with type 2 diabetes with an OR of 1.34 (95% CI 1.15, 1.56, p = 0.0002 under a dominant model, and 95% CI 1.16, 1.55, p = 0.0002 under an additive model) in the Han Chinese population, corresponding to a population attributable risk fraction of 5.0%.
  
  
  CONCLUSIONS
  HMGA1 is an important susceptibility locus that confers a high cross-race risk of the development of type 2 diabetes.
authors.affiliation: Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, 430030 Wuhan, People's Republic of China.
authors.forename: L
authors.initials: L
authors.lastname: Liu
authors.forename: H
authors.initials: H
authors.lastname: Ding
authors.forename: H R
authors.initials: HR
authors.lastname: Wang
authors.forename: Y J
authors.initials: YJ
authors.lastname: Xu
authors.forename: G L
authors.initials: GL
authors.lastname: Cui
authors.forename: P H
authors.initials: PH
authors.lastname: Wang
authors.forename: G
authors.initials: G
authors.lastname: Yuan
authors.forename: X F
authors.initials: XF
authors.lastname: Yu
authors.forename: D W
authors.initials: DW
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005260:Female; D005838:Genotype; D024003:HMGA Proteins / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*
chemical_list: D024003:HMGA Proteins