title: A nano-sized Au electrode fabricated using lithographic technology for electrochemical detection of dopamine.
abstract: One big challenge of fabricating nanosensors for spatially resolved electrochemical detection of neurochemicals, such as dopamine (DA), is the difficulty to assembly nanometer-scale patternable and integrated sensors. In this work we develop a novel approach to precisely manufacture nano-Au-electrode (NAE) using lithographic fabrication technique, and characterize the NAE for DA detection. A negative photoresist, SU-8, is used as a substrate and protection layer for the 127-nm Au active sensing layer. The cross surface morphology and thickness of the Au layer are imaged by scanning electron microscopy and an interference microscopy. This NAE could be precisely controlled, repeatedly fabricated and conveniently renewed for several times. The electrochemical sensitivity and selectivity of the NAE towards DA detection are significantly higher than those of a standard Au thin-film electrode. This work demonstrates that the NAE could be used as an attractive means for electrochemically sensing and recording DA.
authors.affiliation: Department of Chemistry, University of Science & Technology of China, Hefei 230026, China.
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhao
authors.affiliation: Department of Chemistry, University of Science & Technology of China, Hefei 230026, China.
authors.forename: Shu-Hong
authors.initials: SH
authors.lastname: Li
authors.affiliation: Department of Chemistry, University of Science & Technology of China, Hefei 230026, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Chu
authors.affiliation: Department of Chemistry, University of Science & Technology of China, Hefei 230026, China.
authors.forename: You-Peng
authors.initials: YP
authors.lastname: Chen
authors.affiliation: Department of Chemistry, University of Science & Technology of China, Hefei 230026, China.
authors.forename: Wen-Wei
authors.initials: WW
authors.lastname: Li
authors.affiliation: Department of Chemistry, University of Science & Technology of China, Hefei 230026, China. Electronic address: hqyu@ustc.edu.cn.
authors.forename: Han-Qing
authors.initials: HQ
authors.lastname: Yu
authors.affiliation: National Synchrotron Radiation Laboratory, University of Science & Technology of China, Hefei 230026, China.
authors.forename: Gang
authors.initials: G
authors.lastname: Liu
authors.affiliation: National Synchrotron Radiation Laboratory, University of Science & Technology of China, Hefei 230026, China.
authors.forename: Yang-Chao
authors.initials: YC
authors.lastname: Tian
authors.affiliation: National Synchrotron Radiation Laboratory, University of Science & Technology of China, Hefei 230026, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Xiong
mesh_terms: D001205:Ascorbic Acid; D015374:Biosensing Techniques / Q000295:instrumentation / Q000379:methods* / Q000706:statistics & numerical data; D004298:Dopamine / Q000032:analysis*; D055664:Electrochemical Techniques; D004867:Equipment Design; D006046:Gold; D053768:Metal Nanoparticles / Q000648:ultrastructure; D008855:Microscopy, Electron, Scanning; D015203:Reproducibility of Results
chemical_list: D006046:Gold; D001205:Ascorbic Acid; D004298:Dopamine