title: Common variants in SOCS7 gene predict obesity, disturbances in lipid metabolism and insulin resistance.
abstract: OBJECTIVE
  Specific Suppressor of Cytokine Signaling (SOCS) members, such as SOCS7, may play a role in the development of insulin resistance (IR) owing to their ability to inhibit insulin signaling pathways. The objective was to explore the association between common variants and related haplotypes in SOCS7 gene and metabolic traits related to obesity, lipid metabolism and IR.
  
  
  RESULTS
  780 unrelated men were included in a cross-sectional study. We selected three tagged SNPs that capture 100% of SNPs with minor allele frequency ≥ 0.10. Analyses were done separately for each SNP and followed up by haplotype analysis. rs8074124C was associated with both obesity (p = 0.005) and abdominal obesity (p = 0.002) and allele C carriers showed, in comparison with TT carriers, lower BMI (p = 0.001) and waist circumference (p = 0.001). rs8074124CC- carriers showed lower fasting insulin (p = 0.017) and HOMA-IR (p = 0.018) than allele T carriers. rs12051836C was associated with hypertriglyceridemia (p = 0.009) and hypertriglyceridemic waist (p = 0.006). rs12051836CC- carriers showed lower fasting insulin (p = 0.043) and HOMA-IR (p = 0.042). Haplotype-based association analysis (rs8074124 and rs12051836 in that order) showed associations with lipid and obesity -related phenotypes, consistent with single locus analysis. Haplotype analysis also revealed association between haplotype CT and both decreased HDL-C (p = 0.026) and HDL-C (p = 0.014) as a continuous variable.
  
  
  CONCLUSIONS
  We found, for the first time, significant associations between SOCS7 common variants and related haplotypes and obesity, IR and lipid metabolism disorders.
authors.affiliation: Department of Microbiology, Immunology and Biotechnology, School of Pharmacy and Biochemistry, University of Buenos Aires (UBA), Junín 956 (1113), Ciudad Autónoma de Buenos Aires, Argentina. mtellechea@ffyb.uba.ar
authors.forename: M L
authors.initials: ML
authors.lastname: Tellechea
authors.forename: A Penas
authors.initials: AP
authors.lastname: Steinhardt
authors.forename: G
authors.initials: G
authors.lastname: Rodriguez
authors.forename: M J
authors.initials: MJ
authors.lastname: Taverna
authors.forename: E
authors.initials: E
authors.lastname: Poskus
authors.forename: G
authors.initials: G
authors.lastname: Frechtel
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001118:Argentina; D001794:Blood Pressure; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005787:Gene Frequency; D006239:Haplotypes; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics*; D016014:Linear Models; D050356:Lipid Metabolism / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009687:Nuclear Proteins / Q000235:genetics*; D009765:Obesity / Q000097:blood / Q000235:genetics*; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D057566:Self Report; D050826:Suppressor of Cytokine Signaling Proteins / Q000235:genetics*; D055105:Waist Circumference; D055815:Young Adult
chemical_list: D009687:Nuclear Proteins; C108775:SOCS7 protein, human; D050826:Suppressor of Cytokine Signaling Proteins