title: Anticonvulsant effect of Marsilea quadrifolia Linn. on pentylenetetrazole induced seizure: a behavioral and EEG study in rats.
abstract: BACKGROUND
  Marsilea quadrifolia Linn (MQ) extract has been used traditionally as sedative and antiepileptic drug in India.
  
  
  OBJECTIVE
  To investigate the anticonvulsive potential of MQ extracts by using behavior and electroencephalographic (EEG) analysis on pentylenetetrazole (PTZ) induced seizure model in rats.
  
  
  METHODS
  For anticonvulsant effect, 60minutes after administration of MQ, behavior and EEG were analyzed during PTZ (60mg/kg) induced seizures. Changes of EEG power, latency of onset of seizure, seizure severity score, and duration of epileptic seizure were determined.
  
  
  RESULTS
  Both the water and ethanol extract of MQ increased the latency of seizure but also decreased duration of epileptic seizure and seizure severity score. This reduction of seizure severity was also observed in EEG recording and EEG power analysis. The effectiveness of MQ ethanol extract is better than MQ water extract.
  
  
  CONCLUSIONS
  Both water and ethanol extract of MQ were effective in reducing the severity of behavioral and EEG seizures induced by PTZ in rats. This study justifies the traditional use of this plant in epilepsy.
authors.affiliation: Department of Human Physiology with Community Health, Vidyasagar University, Midnapore, West Bengal, India.
authors.forename: Surajit
authors.initials: S
authors.lastname: Sahu
authors.forename: Goutam
authors.initials: G
authors.lastname: Dutta
authors.forename: Nilotpal
authors.initials: N
authors.lastname: Mandal
authors.forename: Ananda Raj
authors.initials: AR
authors.lastname: Goswami
authors.forename: Tusharkanti
authors.initials: T
authors.lastname: Ghosh
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000302:isolation & purification / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology; D058256:Brain Waves / Q000187:drug effects*; D004195:Disease Models, Animal; D004569:Electroencephalography; D008297:Male; D043964:Marsileaceae / Q000737:chemistry; D000432:Methanol / Q000737:chemistry; D009043:Motor Activity / Q000187:drug effects; D010433:Pentylenetetrazole; D008517:Phytotherapy; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control* / Q000523:psychology; D012997:Solvents / Q000737:chemistry; D013997:Time Factors; D014867:Water / Q000737:chemistry
chemical_list: D000927:Anticonvulsants; D010936:Plant Extracts; D012997:Solvents; D014867:Water; D010433:Pentylenetetrazole; D000432:Methanol