title: Changes in peripheral innervation and nociception in reticular type and erosive type of oral lichen planus.
abstract: BACKGROUND
  Oral lichen planus (OLP) is a chronic inflammatory lesion in oral mucosa. Reticular (OLP-R) and erosive (OLP-E) types of OLP are the common forms that have been found in dental clinics. The aim of this investigation is to determine the correlation between neurogenic inflammation and nociception associated with OLP-R and OLP-E.
  
  
  METHODS
  The oral mucosal lesions from six patients with OLP-E, four with OLP-R and three with noninflamed oral mucosa, which represent normal mucosa, were identified by morphometric analysis of nerve fibers containing immunoreactive protein gene product (PGP) 9.5. The level of inflammation was measured with hematoxylin and eosin staining and the level of nociception was analyzed with visual analog scale measurement.
  
  
  RESULTS
  We found that 1) an increase in peripheral innervation was related to the size of the area of inflammatory cell infiltration from both OLP-R and OLP-E; 2) the pattern of PGP 9.5-immunoreactivity among OLP-R and OLP-E was not significantly different (P=0.23); and 3) the correlation between nociception and an increase in PGP 9.5-immunoreactivity was not found in OLP-E and in OLP-R.
  
  
  CONCLUSIONS
  Our findings suggest that an increase in peripheral innervation may lead to increased inflammation, which is part of the immunopathogenesis of OLP. Differences in nociception between OLP-R and OLP-E arise from the pathogenesis of each lesion, not from the differences in peripheral innervation.
authors.affiliation: Department of Oral Biology and Diagnostic Science, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand. s.chat@chiangmai.ac.th
authors.forename: Siriporn
authors.initials: S
authors.lastname: Chattipakorn
authors.forename: Jitjiroj
authors.initials: J
authors.lastname: Ittichaicharoen
authors.forename: Samreung
authors.initials: S
authors.lastname: Rangdaeng
authors.forename: Nipon
authors.initials: N
authors.lastname: Chattipakorn
mesh_terms: D000328:Adult; D000368:Aged; D001485:Basement Membrane / Q000294:innervation; D015415:Biomarkers / Q000032:analysis; D001706:Biopsy; D003238:Connective Tissue / Q000473:pathology; D004848:Epithelium / Q000294:innervation; D006801:Humans; D017676:Lichen Planus, Oral / Q000145:classification / Q000473:pathology*; D008214:Lymphocytes / Q000473:pathology; D008875:Middle Aged; D009061:Mouth Mucosa / Q000294:innervation*; D009412:Nerve Fibers / Q000473:pathology; D009416:Nerve Regeneration / Q000502:physiology; D009437:Neuralgia / Q000473:pathology; D059226:Nociceptive Pain / Q000473:pathology*; D010147:Pain Measurement; D043222:Ubiquitin Thiolesterase / Q000032:analysis; D055815:Young Adult
chemical_list: D015415:Biomarkers; C482860:UCHL1 protein, human; D043222:Ubiquitin Thiolesterase