title: Mouse model of oropharyngeal candidiasis.
abstract: Oropharyngeal candidiasis is a frequent cause of morbidity in patients with defects in cell-mediated immunity or saliva production. Animal models of this infection are important for studying disease pathogenesis and evaluating vaccines and antifungal therapies. Here we describe a simple mouse model of oropharyngeal candidiasis. Mice are rendered susceptible to oral infection by injection with cortisone acetate and then inoculated by placing a swab saturated with Candida albicans sublingually. This process results in a reproducible level of infection, the histopathology of which mimics that of pseudomembranous oropharyngeal candidiasis in humans. By using this model, data are obtained after 5-9 d of work.
authors.affiliation: Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, USA.
authors.forename: Norma V
authors.initials: NV
authors.lastname: Solis
authors.forename: Scott G
authors.initials: SG
authors.lastname: Filler
mesh_terms: D000818:Animals; D002176:Candida albicans; D002180:Candidiasis, Oral / Q000382:microbiology / Q000473:pathology*; D003348:Cortisone / Q000031:analogs & derivatives / Q000494:pharmacology; D004195:Disease Models, Animal; D007166:Immunosuppressive Agents / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D010608:Pharyngeal Diseases / Q000382:microbiology*
chemical_list: D007166:Immunosuppressive Agents; D003348:Cortisone