title: Riedel's thyroiditis - a case report with genes' expression studies.
abstract: BACKGROUND
  Genetic background of Riedel's thyroiditis remains unknown. Herein, we describe our results of studies on genes expression levels in Riedel's thyroiditis.
  We report the case of 48-year old woman with Riedel's thyroiditis who has presented unusual course of disease with non-specific cervical discomfort, though as with no pain and/or no compression symptoms. After surgery, thyroid specimens were quantitatively evaluated, regarding PIK3CA, PIK3CD, PIK3CG, Tg, TGFB1, THRB, COL1, CDKN1C, CDH3 and CACNA2D2 genes expression levels, by real-time PCR in the ABI PRISM® 7500 Sequence Detection System. Out of 10 above genes, in 2 cases the expression was higher than in respective Controls of unchanged thyroid tissue. In the remaining 8 cases, expression in question became comparable or lower as in Controls.
  
  
  CONCLUSIONS
  The association between increased expression levels of PIK3CA and CDH3 genes and Riedel's thyroiditis is not well-defined. However, the increased expression of PIK3CA and CDH3 genes in our case report and in previous studies of other authors on various malignancies may suggest possible molecular relation between Riedel's thyroiditis and certain neoplastic processes, the relation of which requires further genetic evaluation. It is to be stressed that gene expression studies in Riedel's thyroiditis are difficult to perform, mainly due to fibrosis, resulting in scarce thyroid specimens and - in consequence - small amount of genetic material.
authors.affiliation: Department of Endocrinology and Metabolic Diseases, Polish Mother's Memorial Hospital Research Institute, Medical University of Lodz, Rzgowska St, No, 281/289, 93-338 Lodz, Poland. alewin@csk.umed.lodz.pl.
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Wojciechowska-Durczyńska
authors.forename: Adam
authors.initials: A
authors.lastname: Durczyński
authors.forename: Stanisław
authors.initials: S
authors.lastname: Sporny
authors.forename: Janusz
authors.initials: J
authors.lastname: Strzelczyk
authors.forename: Andrzej
authors.initials: A
authors.lastname: Lewiński