title: Platycodi Radix suppresses development of atopic dermatitis-like skin lesions.
abstract: Platycodi Radix has been used to treat chronic diseases, such as bronchitis, asthma, and hyperlipidemia. In this study, we examined the effect of an aqueous extract, Changkil (CK), from the root of Platycodi Radix on 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD)-like skin lesions. Administration of CK onto DNCB-induced AD-like skin lesions in NC/Nga mice ameliorated lesion intensity scores, levels of IgE, thymus and activation-regulated chemokine (TARC), TNF-α, and IL-4 in serum and ears. In contrast, CK increased level of the immunosuppressive cytokine IL-10. Histopathological examination showed reduced thickness of the epidermis/dermis and dermal infiltration of inflammatory cells in the ears. CK also suppressed TNF-α/IFN-γ-induced mRNA expression and production of TARC in HaCaT cells. CK exerts beneficial effects on AD symptoms, suggesting that CK is an effective potential therapeutic agent for AD.
authors.affiliation: Department of Toxicology, College of Pharmacy, Chungnam National University, Daejeon, Republic of Korea.
authors.forename: Jae Ho
authors.initials: JH
authors.lastname: Choi
authors.forename: Eun Hee
authors.initials: EH
authors.lastname: Han
authors.forename: Bong Hwan
authors.initials: BH
authors.lastname: Park
authors.forename: Hyung Gyun
authors.initials: HG
authors.lastname: Kim
authors.forename: Yong Pil
authors.initials: YP
authors.lastname: Hwang
authors.forename: Young Chul
authors.initials: YC
authors.lastname: Chung
authors.forename: Young Chun
authors.initials: YC
authors.lastname: Lee
authors.forename: Hye Gwang
authors.initials: HG
authors.lastname: Jeong
mesh_terms: D000818:Animals; D018926:Anti-Allergic Agents / Q000627:therapeutic use*; D002460:Cell Line; D002470:Cell Survival; D054414:Chemokine CCL17 / Q000097:blood; D016207:Cytokines / Q000097:blood / Q000235:genetics; D003876:Dermatitis, Atopic / Q000188:drug therapy* / Q000378:metabolism; D004137:Dinitrochlorobenzene; D004195:Disease Models, Animal; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007509:Irritants; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000627:therapeutic use*; D018517:Plant Roots; D031238:Platycodon; D012333:RNA, Messenger / Q000378:metabolism
chemical_list: D018926:Anti-Allergic Agents; C499538:Ccl17 protein, mouse; C440574:Changkil; D054414:Chemokine CCL17; D016207:Cytokines; D004137:Dinitrochlorobenzene; D007509:Irritants; D010936:Plant Extracts; D012333:RNA, Messenger; D007073:Immunoglobulin E