title: Systematic review and meta-analysis: Helicobacter pylori eradication therapy after simple closure of perforated duodenal ulcer.
abstract: BACKGROUND
  The most common complications of peptic ulcer are bleeding and perforation. In many regions, definitive acid reduction surgery has given way to simple closure and Helicobacter pylori eradication.
  
  
  OBJECTIVE
  To perform a systematic review and meta-analysis to ask whether this change in practice is in fact justified.
  
  
  METHODS
  A search on the Cochrane Controlled Trials Register, Medline, and Embase was made for controlled trials of duodenal ulcer perforation patients using simple closure method plus postoperative H. pylori eradication therapy versus simple closure plus antisecretory non-eradication therapy. The long-term results for prevention of ulcer recurrence were compared.
  
  
  RESULTS
  The pooled incidence of 1-year ulcer recurrence in H. pylori eradication group was 5.2% [95% confidence interval (CI) of 0.7 and 9.7], which is significantly lower than that of the control group (35.2%) with 95% CI of 0.25 and 0.45. The pooled relative risk was 0.15 with 95% CI of 0.06 and 0.37.
  
  
  CONCLUSIONS
  Helicobacter pylori eradication after simple closure of duodenal ulcer perforation gives better result than the operation plus antisecretory non-eradication therapy for prevention of ulcer recurrence. All duodenal ulcer perforation patients should be tested for H. pylori infection, and eradication therapy is required in all infected patients.
authors.affiliation: Department of Surgery, Faculty of Medicine, Thammasat University, Pathumthani, Thailand. ptomtitchong@gmail.com
authors.forename: Prakitpunthu
authors.initials: P
authors.lastname: Tomtitchong
authors.forename: Boonying
authors.initials: B
authors.lastname: Siribumrungwong
authors.forename: Ratha-Korn
authors.initials: RK
authors.lastname: Vilaichone
authors.forename: Petch
authors.initials: P
authors.lastname: Kasetsuwan
authors.forename: Norio
authors.initials: N
authors.lastname: Matsukura
authors.forename: Nathorn
authors.initials: N
authors.lastname: Chaiyakunapruk
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D016481:Helicobacter Infections / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery*; D016480:Helicobacter pylori / Q000302:isolation & purification / Q000502:physiology; D006801:Humans; D010439:Peptic Ulcer Perforation / Q000188:drug therapy* / Q000382:microbiology / Q000601:surgery*; D016032:Randomized Controlled Trials as Topic
chemical_list: D000900:Anti-Bacterial Agents