title: Mechanisms of suppression of interferon production by porcine reproductive and respiratory syndrome virus.
abstract: The recently emerged porcine reproductive and respiratory syndrome virus (PRRSV) leads to one of the most economically significant infectious diseases of swine worldwide. The virus modulates the host innate and adaptive immunity to escape its immune response to facilitate the infection. Interferons (INFs) are principal antiviral cytokines, which represent components of the innate immunity and are regarded as a bridge between the innate and adaptive immunity. Currently, accumulating evidence indicates that the virus has developed various strategies to counteract the IFN production. Here, various mechanisms utilized by the virus to antagonize the IFN induction are reviewed.
authors.affiliation: Chinese Academy of Agricultural Science, Shanghai, People's Republic of China.
authors.forename: L
authors.initials: L
authors.lastname: Zhu
authors.forename: Y
authors.initials: Y
authors.lastname: Zhou
authors.forename: G
authors.initials: G
authors.lastname: Tong
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D053487:DEAD-box RNA Helicases / Q000235:genetics / Q000276:immunology; D015870:Gene Expression / Q000276:immunology*; D054884:Host-Pathogen Interactions / Q000276:immunology*; D007113:Immunity, Innate; D016899:Interferon-beta / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D016676:Macrophages, Alveolar / Q000276:immunology* / Q000821:virology; D016328:NF-kappa B / Q000235:genetics / Q000276:immunology; D019318:Porcine Reproductive and Respiratory Syndrome / Q000235:genetics / Q000276:immunology / Q000821:virology*; D019316:Porcine respiratory and reproductive syndrome virus / Q000502:physiology*; D011485:Protein Binding; D015398:Signal Transduction / Q000276:immunology; D013552:Swine; D051196:Toll-Like Receptor 3 / Q000235:genetics / Q000276:immunology; D017361:Viral Nonstructural Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D016328:NF-kappa B; D051196:Toll-Like Receptor 3; D017361:Viral Nonstructural Proteins; D016899:Interferon-beta; D053487:DEAD-box RNA Helicases