title: Low Plasma Hdl Cholesterol and Elevated C Reactive Protein further Increase Cardiovascular Disease Risk in Latinos with Type 2 Diabetes.
abstract: The purpose of this study was to determine whether low plasma HDL and high C reactive protein (CRP) concentrations would further increase cardiovascular disease (CVD) risk in Latinos with poorly controlled type-2 diabetes, already at high risk for CVD. Subjects (n = 68) were grouped into High-HDL (≥ or 1.03 or 1.3 mmol/L) or Low-HDL (<1.03 or 1.3 mmol/L) for men and women, respectively. Following classification, risk factors for CVD including apolipoproteins, lipoprotein size and subfraction distribution were assesed. Similarly, participants were divided according to their CRP levels (≥ or < 3mg/L) and key inflammatory markers as well as leptin and adiponectin were analyzed. The Low-HDL group had higher concentrations of the atherogenic particles, large and medium VLDL and the smaller LDL subfractions compared to the High-HDL group (p<0.001). Consistently, VLDL diameter was larger and LDL diameter smaller in the Low HDL group (p<0.001). The High-CRP group had larger waist circumference (p<0.001) and body mass index (p<0.001) than the Low-CRP group. Leptin was also higher in the High- CRP group (p< 0.01). These data suggest that Latinos with type-2 diabetes having either Low-HDL or High-CRP concentrations are at a higher risk for atherosclerosis and CVD than their counterparts who have High-HDL or Low-CRP.
authors.affiliation: Department of Nutritional Sciences, University of Connecticut, 3624 Horsebarn Rd Ext, CT 06269, USA.
authors.forename: Mariana C
authors.initials: MC
authors.lastname: Calle
authors.forename: Sonia
authors.initials: S
authors.lastname: Vega-López
authors.forename: Sofia
authors.initials: S
authors.lastname: Segura-Pérez
authors.forename: Jeff S
authors.initials: JS
authors.lastname: Volek
authors.forename: Rafael
authors.initials: R
authors.lastname: Pérez-Escamilla
authors.forename: Maria Luz
authors.initials: ML
authors.lastname: Fernandez