title: Scintigraphy at 3 months after single lung transplantation and observations of primary graft dysfunction and lung function.
abstract: Scintigraphy has been used as a tool to detect dysfunction of the lung before and after transplantation. The aims of this study were to evaluate the development of the ventilation-perfusion relationships in single lung transplant recipients in the first year, at 3 months after transplantation, and to investigate whether scintigraphic findings at 3 months were predictive for the outcome at 12 months in relation to primary graft dysfunction (PGD) and lung function. A retrospective study was carried out on all patients who prospectively and consecutively were referred for a routine lung scintigraphy procedure 3 months after single lung transplantation (SLTX). A total of 41 patients were included in the study: 20 women and 21 men with the age span of patients at transplantation being 38-66 years (mean ± SD: 54.2 ± 6.0). Patient records also included lung function tests and chest X-ray images. We found no significant correlation between lung function distribution at 3 months and PGD at 72 h. There was also no significant correlation between PGD scores at 72 h and lung function at 6 and 12 months. The same applied to scintigraphic scores for heterogeneity at 3 months compared with lung function at 6 and 12 months. Fifty-five percent of all patients had decreased ventilation function measured in the period from 6 to 12 months. Forty-nine percent of the patients had normal perfusion evaluations, and 51% had abnormal perfusion evaluations at 3 months. For ventilation evaluations, 72% were normal and 28% were abnormal. There was a significant difference in the normal versus abnormal perfusion and ventilation scintigraphic images evaluated from the same patients. Ventilation was distributed more homogenously in the transplanted lung than perfusion in the same lung. The relative distribution of perfusion and ventilation to the transplanted lung of patients with and without a primary diagnosis of fibrosis did not differ significantly from each other. We conclude that PGD defined at 72 h does not lead to recognizable changes in ventilation-perfusion scintigrapy at 3 months, and scintigraphic findings do not correlate with development in lung function in the first 12 months.
authors.affiliation: Department of Radiology, Diagnostic Imaging Centre, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark. esther.belmaati@rh.regionh.dk
authors.forename: Esther Okeke
authors.initials: EO
authors.lastname: Belmaati
authors.forename: Martin
authors.initials: M
authors.lastname: Iversen
authors.forename: Klaus F
authors.initials: KF
authors.lastname: Kofoed
authors.forename: Michael B
authors.initials: MB
authors.lastname: Nielsen
authors.forename: Jann
authors.initials: J
authors.lastname: Mortensen
mesh_terms: D000328:Adult; D000368:Aged; D003718:Denmark; D005260:Female; D006801:Humans; D016040:Lung Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D055420:Perfusion Imaging; D011237:Predictive Value of Tests; D055031:Primary Graft Dysfunction / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology; D012123:Pulmonary Ventilation; D019275:Radiopharmaceuticals; D012129:Respiratory Function Tests; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D019275:Radiopharmaceuticals