title: Cranial and related sensorimotor impairments in rodent models of Parkinson's disease.
abstract: In Parkinson's disease both limb and cranial sensorimotor functions are impaired, leading to a profound diminished quality of life for many patients. Toxin and genetic animal models of Parkinson's disease are likely essential for understanding the pathology associated with these impairments as well as for the development and testing of potential therapeutics. Here we describe useful novel and established behavioral outcome measures for assessing limb and cranial sensorimotor functions in toxin and genetic models of parkinsonism in rats and mice.
authors.affiliation: Departments of Psychology and Neurology, University of Cincinnati, Cincinnati, OH 45221-0376, USA. fleminsa@ucmail.uc.edu
authors.forename: Sheila M
authors.initials: SM
authors.lastname: Fleming
authors.forename: Tim
authors.initials: T
authors.lastname: Schallert
authors.forename: Michelle R
authors.initials: MR
authors.lastname: Ciucci
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D001921:Brain / Q000503:physiopathology*; D001923:Brain Chemistry / Q000235:genetics / Q000502:physiology*; D004195:Disease Models, Animal; D005247:Feeding Behavior / Q000502:physiology; D020267:MPTP Poisoning / Q000378:metabolism / Q000503:physiopathology / Q000523:psychology; D051379:Mice; D009043:Motor Activity / Q000502:physiology; D009068:Movement / Q000502:physiology; D009069:Movement Disorders / Q000235:genetics / Q000503:physiopathology* / Q000523:psychology; D009425:Nesting Behavior / Q000502:physiology; D016627:Oxidopamine; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000235:genetics / Q000503:physiopathology* / Q000523:psychology; D004856:Postural Balance / Q000502:physiology; D011597:Psychomotor Performance / Q000502:physiology; D051381:Rats; D012678:Sensation Disorders / Q000235:genetics / Q000503:physiopathology* / Q000523:psychology; D013565:Sympatholytics; D014828:Vocalization, Animal / Q000502:physiology
chemical_list: D013565:Sympatholytics; D016627:Oxidopamine