title: TRPV1 activation prevents nonalcoholic fatty liver through UCP2 upregulation in mice.
abstract: Nonalcoholic fatty liver is characterized by the fatty deformation and lipid deposition of hepatic parenchymal cells that are associated with cardiometabolic diseases. In this study, we report the effect of capsaicin on its receptor, transient receptor potential vanilloid 1 (TRPV1) cation channel, in preventing fatty liver formation. Functional TRPV1 has been detected in hepatocytes and liver tissues. TRPV1 activation by capsaicin reduced lipid accumulation and triglyceride level in the liver from wild-type (WT) mice. However, these effects were absent in the liver from TRPV1(-/-) mice. Chronic dietary capsaicin increased the hepatic uncoupling protein 2 (UCP2) expression in WT but not in TRPV1(-/-) mice (P < 0.01). We conclude that TRPV1 long-time activation might prevent high-fat diet-induced fatty liver in mice through upregulation of hepatic UCP2. Dietary capsaicin may represent a promising intervention in populations at high risk for fatty liver.
authors.affiliation: Center for Hypertension and Metabolic Diseases, Department of Hypertension and Endocrinology, Daping Hospital, Chongqing Institute of Hypertension, Third Military Medical University, Chongqing, 400042, China.
authors.forename: Li
authors.initials: L
authors.lastname: Li
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.forename: Yinxing
authors.initials: Y
authors.lastname: Ni
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Feng
authors.forename: Zhigang
authors.initials: Z
authors.lastname: Zhao
authors.forename: Peijian
authors.initials: P
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: Sun
authors.forename: Hao
authors.initials: H
authors.lastname: Yu
authors.forename: Zhencheng
authors.initials: Z
authors.lastname: Yan
authors.forename: Daoyan
authors.initials: D
authors.lastname: Liu
authors.forename: Bernd
authors.initials: B
authors.lastname: Nilius
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Zhu
mesh_terms: D000818:Animals; D002211:Capsaicin / Q000378:metabolism; D002478:Cells, Cultured; D059305:Diet, High-Fat / Q000009:adverse effects; D004042:Dietary Fats, Unsaturated / Q000378:metabolism; D005234:Fatty Liver / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D056945:Hep G2 Cells; D022781:Hepatocytes / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007473:Ion Channels / Q000235:genetics* / Q000378:metabolism*; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D024101:Mitochondrial Proteins / Q000235:genetics* / Q000378:metabolism*; D065626:Non-alcoholic Fatty Liver Disease; D050916:TRPV Cation Channels / Q000378:metabolism*; D014280:Triglycerides / Q000378:metabolism; D000071246:Uncoupling Protein 2; D015854:Up-Regulation
chemical_list: D004042:Dietary Fats, Unsaturated; D007473:Ion Channels; D024101:Mitochondrial Proteins; D050916:TRPV Cation Channels; C493921:TRPV1 protein, mouse; D014280:Triglycerides; C000604389:UCP2 protein, human; C000604390:Ucp2 protein, mouse; D000071246:Uncoupling Protein 2; D002211:Capsaicin