title: Curcumin has neuroprotection effect on homocysteine rat model of Parkinson.
abstract: Parkinson's disease (PD) is a progressive neurological disorder which is emanated by dopaminergic death cell and depletion. Curcumin as a nontoxic matter has antioxidant, anti-inflammatory, and antiproliferative activities, and it involves antioxidant property same to vitamins C and E. In this study, we investigated the neuroprotective properties of the natural polyphenolic antioxidant compound, curcumin, against homocysteine (Hcy) neurotoxicity. Curcumin (50 mg/kg) was injected intraperitoneally (i.p.) once daily for a period of 10 days beginning 5 days prior to Hcy (2 μmol/μl) intracerebroventricular (i.c.v.) injection in rats. The studies included immunohistological and locomotor activity tests. These results suggest that homocysteine intracerebroventricular administration (2 μmol/μl i.c.v.) may induce changes in rat brain, and subsequently, polyphenol treatment curcumin 50 mg/kg (i.p.) was capable in improving locomotor function in insulted animal by protecting the nervous system against homocysteine toxicity.
authors.affiliation: Neuroscience Research Center, Shahid Beheshti University of Medical Science, Tehran, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Mansouri
authors.forename: Masoumeh
authors.initials: M
authors.lastname: Sabetkasaei
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Moradi
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Masoudnia
authors.forename: Amin
authors.initials: A
authors.lastname: Ataie
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D000975:Antioxidants / Q000378:metabolism; D001921:Brain / Q000187:drug effects* / Q000473:pathology; D003474:Curcumin / Q000378:metabolism* / Q000494:pharmacology; D004195:Disease Models, Animal; D004347:Drug Interactions; D006710:Homocysteine / Q000378:metabolism / Q000633:toxicity*; D008297:Male; D018696:Neuroprotective Agents / Q000378:metabolism*; D020734:Parkinsonian Disorders / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D018696:Neuroprotective Agents; D006710:Homocysteine; D003474:Curcumin