title: Rationale for and current status of prenatal cardiac intervention.
abstract: The idea of prenatal intervention in congenital heart defects was put forward over 20 years ago, arising from the observation that some forms of cardiac malformation progressed in severity as pregnancy advanced. The simultaneous development of minimally invasive catheter techniques in children, led to the concept of treating the foetal heart directly, in an attempt to prevent the changes which had been observed. Early efforts at prenatal valvuloplasty were largely set aside after poor results and the coincidental development of alternative, increasingly successful, postnatal surgical strategies. However, in the last 10 years or so, some centres have revived and extended the interventional techniques, with some success. The application of these techniques is limited to very few conditions, and suitable cases are relatively uncommon. Exploration of these procedures, therefore, should be limited to very few centres and the results should be closely scrutinised before this becomes an accepted management option.
authors.affiliation: Harris Birthright Centre for Fetal Medicine, King's College Hospital, Denmark Hill, London, SE5 9RS, UK. lindsey.allan@nhs.net
authors.forename: Lindsey D
authors.initials: LD
authors.lastname: Allan
mesh_terms: D001024:Aortic Valve Stenosis / Q000000981:diagnostic imaging / Q000196:embryology / Q000601:surgery; D063126:Balloon Valvuloplasty / Q000379:methods*; D005318:Fetal Heart / Q000000981:diagnostic imaging / Q000601:surgery*; D046128:Fetal Therapies / Q000266:history / Q000379:methods*; D006330:Heart Defects, Congenital / Q000000981:diagnostic imaging / Q000601:surgery*; D049673:History, 20th Century; D049674:History, 21st Century; D017410:Practice Guidelines as Topic; D014463:Ultrasonography