title: Ion-sensitive field-effect transistor for biological sensing.
abstract: In recent years there has been great progress in applying FET-type biosensors for highly sensitive biological detection. Among them, the ISFET (ion-sensitive field-effect transistor) is one of the most intriguing approaches in electrical biosensing technology. Here, we review some of the main advances in this field over the past few years, explore its application prospects, and discuss the main issues, approaches, and challenges, with the aim of stimulating a broader interest in developing ISFET-based biosensors and extending their applications for reliable and sensitive analysis of various biomolecules such as DNA, proteins, enzymes, and cells.
authors.affiliation: BioNanotechnology Research Center (BNRC), Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon 305-333, Korea; E-Mail:  cslee@kribb.re.kr  (C.-S.L.);  tech81@hanmail.net  (S.K.K.).
authors.forename: Chang-Soo
authors.initials: CS
authors.lastname: Lee
authors.forename: Sang Kyu
authors.initials: SK
authors.lastname: Kim
authors.forename: Moonil
authors.initials: M
authors.lastname: Kim