title: The immune contexture in human tumours: impact on clinical outcome.
abstract: Tumours grow within an intricate network of epithelial cells, vascular and lymphatic vessels, cytokines and chemokines, and infiltrating immune cells. Different types of infiltrating immune cells have different effects on tumour progression, which can vary according to cancer type. In this Opinion article we discuss how the context-specific nature of infiltrating immune cells can affect the prognosis of patients.
authors.affiliation: INSERM UMRS872, Laboratory of Immune microenvironment and tumours, Paris F75006, France.
authors.forename: Wolf Herman
authors.initials: WH
authors.lastname: Fridman
authors.forename: Franck
authors.initials: F
authors.lastname: Pagès
authors.forename: Catherine
authors.initials: C
authors.lastname: Sautès-Fridman
authors.forename: Jérôme
authors.initials: J
authors.lastname: Galon
mesh_terms: D000818:Animals; D018925:Chemokines / Q000378:metabolism; D016207:Cytokines / Q000378:metabolism; D018572:Disease-Free Survival; D006801:Humans; D051379:Mice; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D011379:Prognosis; D059016:Tumor Microenvironment; D042461:Vascular Endothelial Growth Factor A / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D018925:Chemokines; D016207:Cytokines; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A