title: Mapping gene-environment interactions at regulatory polymorphisms: insights into mechanisms of phenotypic variation.
abstract: Genetic effects on gene regulation make a substantial contribution to phenotypic diversity, yet their mechanisms remain elusive. Here, we discuss the potential insights to be gained from mapping gene-environment interactions at regulatory polymorphisms (i.e., genetic variation that affects gene expression under specific environmental conditions). We highlight a novel statistical method to identify specific patterns of gene-environment interaction at these regulatory polymorphisms. Reviewing its application to a study that mapped gene expression in the presence and absence of glucocorticoids, we discuss the mechanistic insights that this approach provides.
authors.affiliation: Department of Human Genetics, The University of Chicago, Chicago, IL, USA.
authors.forename: Joseph C
authors.initials: JC
authors.lastname: Maranville
authors.forename: Francesca
authors.initials: F
authors.lastname: Luca
authors.forename: Matthew
authors.initials: M
authors.lastname: Stephens
authors.forename: Anna
authors.initials: A
authors.lastname: Di Rienzo
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D005786:Gene Expression Regulation; D059647:Gene-Environment Interaction; D014644:Genetic Variation; D005938:Glucocorticoids / Q000378:metabolism; D006801:Humans; D010641:Phenotype; D011110:Polymorphism, Genetic; D040641:Quantitative Trait Loci; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D005938:Glucocorticoids; D014157:Transcription Factors