title: Ruthenium-catalyzed [2+2+2] cycloaddition of diynes with nitriles in pure water.
abstract: One ring to bind them: An efficient method for synthesizing highly functionalized pyridine derivatives from diynes and nitriles is described. The reaction system involves Cp*Ru(COD)Cl/tppts-catalyzed [2+2+2] cycloaddition in pure water. Without being accompanied by diyne dimerization or trimerization byproducts, the desired products can be obtained in moderate to high yields.
authors.affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Sciences, 457 Zhongshan Road, Dalian 116023, PR China.
authors.forename: Fen
authors.initials: F
authors.lastname: Xu
authors.forename: Chunxiang
authors.initials: C
authors.lastname: Wang
authors.forename: Xincheng
authors.initials: X
authors.lastname: Li
authors.forename: Boshun
authors.initials: B
authors.lastname: Wan
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D055772:Green Chemistry Technology; D009570:Nitriles / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D013379:Substrate Specificity; D014867:Water / Q000737:chemistry*
chemical_list: D000480:Alkynes; D009570:Nitriles; D011725:Pyridines; D012997:Solvents; D014867:Water; D012428:Ruthenium; C023666:pyridine