title: Assessment of additional endpoints for trials in acute stroke - what, when, where, in who?
abstract: Functional outcome in acute stroke trials among others is usually measured on the modified Rankin Scale. However, new onset of depression, cognitive decline, and communication deficits alone or in combination affect more than 25% of patients. This report summarizes the findings and conclusions of a workshop by the European Stroke Organization held in February 2011 We propose that assessment of mood disorders, cognitive impairment/dementia, language or communication dysfunction, and quality of life should supplement outcome measures after acute stroke.
authors.affiliation: Department of Neurology, Johannes Wesling Klinikum Minden, Minden, Germany. Peter.Schellinger@muehlenkreiskliniken.de
authors.forename: Peter D
authors.initials: PD
authors.lastname: Schellinger
authors.forename: Philip M W
authors.initials: PM
authors.lastname: Bath
authors.forename: Kennedy R
authors.initials: KR
authors.lastname: Lees
authors.forename: Natan M
authors.initials: NM
authors.lastname: Bornstein
authors.forename: Eitan
authors.initials: E
authors.lastname: Uriel
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Eisert
authors.forename: Didier
authors.initials: D
authors.lastname: Leys
mesh_terms: D002986:Clinical Trials as Topic; D003072:Cognition Disorders / Q000175:diagnosis / Q000523:psychology / Q000628:therapy; D003863:Depression / Q000175:diagnosis / Q000523:psychology / Q000628:therapy; D023381:Endpoint Determination / Q000379:methods*; D006801:Humans; D019964:Mood Disorders / Q000175:diagnosis / Q000523:psychology / Q000628:therapy; D011788:Quality of Life / Q000523:psychology*; D020521:Stroke / Q000175:diagnosis / Q000523:psychology* / Q000628:therapy*