title: Nanostructural features of diabetic podocytopathy.
abstract: The earliest glomerular lesion during the diabetic nephropathy is considered by many authors to be the so-called podocytopathy. Microalbuminuria is an early clinical marker of diabetic nephropathy that results from damages of the glomerular filtration barrier at the level of the highly differentiated podocytes. Thus, the diabetic podocytopathy includes cellular hypertrophy, foot process effacement, detachment from glomerular basement membrane (GBM), and apoptosis. The present paper is reviewing all these features and some additional ultrastructural transformations concerning the podocytes involved in the diabetic kidney disease.
authors.affiliation: Department of Nephropathology, Carol Davila Clinical Hospital for Nephrology, Bucharest, Romania. mandache.eugen@yahoo.com
authors.forename: E
authors.initials: E
authors.lastname: Mandache
authors.forename: M
authors.initials: M
authors.lastname: Penescu
mesh_terms: D000818:Animals; D017209:Apoptosis; D003593:Cytoplasm / Q000378:metabolism; D003928:Diabetic Nephropathies / Q000175:diagnosis / Q000473:pathology*; D004195:Disease Models, Animal; D050533:Glomerular Basement Membrane / Q000473:pathology* / Q000648:ultrastructure; D006056:Golgi Apparatus / Q000473:pathology; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology / Q000648:ultrastructure; D008055:Lipids / Q000737:chemistry; D051379:Mice; D008820:Mice, Obese; D050199:Podocytes / Q000473:pathology* / Q000648:ultrastructure
chemical_list: D008055:Lipids