title: Imaging in gynecological disease (7): clinical and ultrasound features of Brenner tumors of the ovary.
abstract: OBJECTIVE
  To describe clinical and ultrasound features of Brenner tumors of the ovary.
  
  
  METHODS
  In this retrospective study, the databases of the International Ovarian Tumor Analysis (IOTA) studies and one tertiary center were searched to identify patients who had undergone an ultrasound scan before surgery for an adnexal mass that proved to be a Brenner tumor. Twenty-eight patients with 29 Brenner tumors were included, most of which had been collected within the framework of the IOTA studies. An experienced ultrasound examiner reviewed available ultrasound images (available for 14 tumors), searching for a pattern specific to Brenner tumors.
  
  
  RESULTS
  Most patients were postmenopausal and asymptomatic. Twenty-four (83%) tumors were benign, two (7%) were borderline and three (10%) were malignant. Most benign tumors (17/24, 71%) contained solid components and manifested no or minimal blood flow on Doppler examination (19/24, 79%). Information about calcifications was available for 15 benign tumors, and in 13 (87%) calcifications were present. The five borderline and invasively malignant tumors contained solid components less often than did the benign ones (3/5, 60%) and were more richly vascularized on Doppler examination. Information about calcifications was available for four borderline or invasively malignant tumors, and in three (75%) calcifications were present.
  
  
  CONCLUSIONS
  We failed to demonstrate ultrasound features specific to Brenner tumors. A prospective study is needed to determine if ultrasound features of calcifications can discriminate between Brenner tumors and other types of ovarian tumor.
authors.affiliation: Department of Obstetrics and Gynecology, Algemeen Ziekenhuis Sint-Lucas, Gent, Belgium.
authors.forename: I
authors.initials: I
authors.lastname: Dierickx
authors.forename: L
authors.initials: L
authors.lastname: Valentin
authors.forename: C
authors.initials: C
authors.lastname: Van Holsbeke
authors.forename: G
authors.initials: G
authors.lastname: Jacomen
authors.forename: A A
authors.initials: AA
authors.lastname: Lissoni
authors.forename: A
authors.initials: A
authors.lastname: Licameli
authors.forename: A
authors.initials: A
authors.lastname: Testa
authors.forename: T
authors.initials: T
authors.lastname: Bourne
authors.forename: D
authors.initials: D
authors.lastname: Timmerman
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001948:Brenner Tumor / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D011300:Preoperative Care / Q000379:methods; D011379:Prognosis; D012189:Retrospective Studies; D047368:Tumor Burden; D018615:Ultrasonography, Doppler, Color