title: Pd(II)-catalyzed direct C5-arylation of azole-4-carboxylates through double C-H bond cleavage.
abstract: The first palladium-catalyzed direct C5-arylation of azole-4-carboxylates with simple unactivated arenes through double C-H bond cleavage is realized. This protocol provided a straightforward access to diverse 5-arylsubstituted azole-4-carboxylic derivatives with good functional group tolerance.
authors.affiliation: State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing, 210009, PR China.
authors.forename: Ziyuan
authors.initials: Z
authors.lastname: Li
authors.forename: Ling
authors.initials: L
authors.lastname: Ma
authors.forename: Jinyi
authors.initials: J
authors.lastname: Xu
authors.forename: Lingyi
authors.initials: L
authors.lastname: Kong
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Wu
authors.forename: Hequan
authors.initials: H
authors.lastname: Yao
mesh_terms: D001393:Azoles / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D010165:Palladium / Q000737:chemistry*
chemical_list: D001393:Azoles; D002264:Carboxylic Acids; D010165:Palladium