title: Aldol elaboration of 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridin-4-ones, masked precursors to acylpyridones.
abstract: A core 4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine-4-one scaffold is elaborated at C-3(Me) by base-mediated aldol condensation to give new 3-alkenyl-4,5,6,7-tetrahydroisoxazolo[4,3-c]pyridine-4-ones, which are masked forms related to the acylpyridone natural products.
authors.affiliation: Department of Chemistry, Loughborough University, Loughborough, Leics. LE11 3TU, United Kingdom.
authors.forename: Raymond C F
authors.initials: RC
authors.lastname: Jones
authors.forename: Abdul K
authors.initials: AK
authors.lastname: Choudhury
authors.forename: James N
authors.initials: JN
authors.lastname: Iley
authors.forename: Mark E
authors.initials: ME
authors.lastname: Light
authors.forename: Georgia
authors.initials: G
authors.lastname: Loizou
authors.forename: Terence A
authors.initials: TA
authors.lastname: Pillainayagam