title: Vascular endothelial growth factor receptor-2 in macular oedema with retinal vein occlusion.
abstract: BACKGROUND
  To evaluate the relationships among vitreous fluid levels of soluble vascular endothelial growth factor receptor-2 (sVEGFR-2), vascular endothelial growth factor (VEGF), and the severity of macular oedema secondary to branch retinal vein occlusion (BRVO).
  
  
  METHODS
  Twenty-five BRVO patients with macular oedema were enrolled. Vitreous fluid samples were obtained during vitreoretinal surgery to measure the levels of sVEGFR-2 and VEGF. Macular oedema was examined by optical coherence tomography.
  
  
  RESULTS
  The vitreous fluid levels of VEGF and sVEGFR-2 were significantly correlated with the severity of macular oedema (ρ = 0.54, p = 0.008 and ρ = 0.40, p = 0.047, respectively). The sVEGFR-2 × VEGF product was also significantly correlated with the severity of macular oedema (ρ = 0.62, p = 0.003).
  
  
  CONCLUSIONS
  The severity of macular oedema was more closely associated with sVEGFR-2 × VEGF than sVEGFR-2 or VEGF alone, suggesting that macular oedema in BRVO patients may be influenced by both VEGF and sVEGFR-2.
authors.affiliation: Department of Ophthalmology, Yachiyo Medical Center, Tokyo Women's Medical University, Chiba, Japan. nomahide@tymc.twmu.ac.jp
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Noma
authors.forename: Hideharu
authors.initials: H
authors.lastname: Funatsu
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Mimura
authors.forename: Shuichiro
authors.initials: S
authors.lastname: Eguchi
mesh_terms: D000368:Aged; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008269:Macular Edema / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism*; D008297:Male; D012170:Retinal Vein Occlusion / Q000150:complications / Q000175:diagnosis / Q000378:metabolism*; D041623:Tomography, Optical Coherence; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000378:metabolism*; D014821:Vitrectomy; D014822:Vitreous Body / Q000378:metabolism
chemical_list: C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D040301:Vascular Endothelial Growth Factor Receptor-2