title: Long-term neuropsychological, neuroanatomical, and life outcome in hippocampal amnesia.
abstract: Focal bilateral hippocampal damage typically causes severe and selective amnesia for new declarative information (facts and events), a cognitive deficit that greatly impacts the ability to live a normal, fully independent life. We describe the case of 1846, a 48-year-old woman with profound hippocampal amnesia following status epilepticus and an associated anoxic episode at age 30. Patient 1846 has undergone extensive neuropsychological testing on many occasions over the 18 years since her injury, and we present data indicating that her memory impairment has remained severe and stable during that time. New, high-resolution, structural MRI studies of 1846's brain reveal substantial bilateral hippocampal atrophy resembling that of other well-known amnesic patients. In spite of severe amnesia 1846 lives a full and mostly independent adult life, facilitated by an extensive social support network of family and friends. Her case provides an example of a rare and unlikely positive outcome in the face of severe memory problems.
authors.affiliation: Department of Neurology, University of Iowa College of Medicine, Iowa City, IA 52242, USA. davideugenewarren@gmail.com
authors.forename: David E
authors.initials: DE
authors.lastname: Warren
authors.forename: Melissa C
authors.initials: MC
authors.lastname: Duff
authors.forename: Vincent
authors.initials: V
authors.lastname: Magnotta
authors.forename: Aristides A
authors.initials: AA
authors.lastname: Capizzano
authors.forename: Martin D
authors.initials: MD
authors.lastname: Cassell
authors.forename: Daniel
authors.initials: D
authors.lastname: Tranel
mesh_terms: D000328:Adult; D000647:Amnesia / Q000209:etiology / Q000473:pathology / Q000523:psychology*; D001284:Atrophy / Q000473:pathology / Q000523:psychology; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008568:Memory; D008875:Middle Aged; D009483:Neuropsychological Tests; D013226:Status Epilepticus / Q000150:complications / Q000473:pathology / Q000523:psychology*