title: Potential utility of resting-state magnetoencephalography as a biomarker of CNS abnormality in HIV disease.
abstract: There is a lack of a neuroimaging biomarker for HIV-Associated Neurocognitive Disorder. We report magnetoencephalography (MEG) data from patients with HIV disease and risk-group appropriate controls that were collected to determine the MEG frequency profile during the resting state, and the stability of the profile over 24 weeks. 17 individuals (10 HIV+, 7 HIV-) completed detailed neurobehavioral evaluations and 10min of resting-state MEG acquisition with a 306-channel whole-head system. The entire evaluation and MEG measurement were repeated 24 weeks later. Relative MEG power in the delta (0-4Hz), theta (4-7Hz), alpha (8-12Hz), beta (12-30Hz) and low gamma (30-50Hz) bands was computed for 8 predefined sensor groups. The median stability of resting-state relative power over 24 weeks of follow-up was .80 with eyes closed, and .72 with eyes open. The relative gamma power in the right occipital (t(15)=1.99, p<.06, r=-.46) and right frontal (t(15)=2.15, p<.05, r=-.48) regions was associated with serostatus. The effect of age on delta power was greater in the seropositive subjects (r(2)=.51) than in the seronegative subjects (r(2)=.11). Individuals with high theta-to-gamma ratios tended to have lower cognitive test performance, regardless of serostatus. The stability of the wide-band MEG frequency profiles over 24 weeks supports the utility of MEG as a biomarker. The links between the MEG profile, serostatus, and cognition suggest further research on its potential in HAND is needed.
authors.affiliation: Department of Psychiatry, University of Pittsburgh, United States; Department of Neurology, University of Pittsburgh, United States.
authors.forename: James T
authors.initials: JT
authors.lastname: Becker
authors.forename: Melissa
authors.initials: M
authors.lastname: Fabrizio
authors.forename: Gustavo
authors.initials: G
authors.lastname: Sudre
authors.forename: Anna
authors.initials: A
authors.lastname: Haridis
authors.forename: Timothy
authors.initials: T
authors.lastname: Ambrose
authors.forename: Howard J
authors.initials: HJ
authors.lastname: Aizenstein
authors.forename: William
authors.initials: W
authors.lastname: Eddy
authors.forename: Oscar L
authors.initials: OL
authors.lastname: Lopez
authors.forename: David A
authors.initials: DA
authors.lastname: Wolk
authors.forename: Lauri
authors.initials: L
authors.lastname: Parkkonen
authors.forename: Anto
authors.initials: A
authors.lastname: Bagic
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000473:pathology*; D003072:Cognition Disorders / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000473:pathology; D006801:Humans; D015225:Magnetoencephalography; D008297:Male; D008875:Middle Aged; D059906:Neuroimaging / Q000379:methods*; D009483:Neuropsychological Tests