title: [Methods for the prevention and treatment of toxico-hypoxic encephalopathy in patients with acute severe poisoning].
abstract: The study included 147 patients with toxico-hypoxic encephalopathy resulting from acute poisoning. It was shown that intensive therapy with cytoflavin (20 ml in 400 ml of 5% glucose solution twice daily for 7 days) reduced severity of hypoxic brain lesions and suppression of CNS as apparent from the improvement of its bioelectric activity. The recovery of CNS regulatory action on the life-sustaining systems of the body promoted normalization of the respiratory component of oxygen transport. The improvement of the patients' conditions in the acute phase contributed to accelerated recovery of cognitive-amnestic functions and social adaptation. Cytoflavin therapy improved the clinical picture of toxico-hypoxic encephalopathy due to the reduction in the duration of the comatose state from 45.3 +/- 8.2 to 27.7 +/- 6.9 hr and the decrease in the frequency of secondary pulmonary complications from 72.7 to 35.9%.
mesh_terms: D000208:Acute Disease; D000328:Adult; D000931:Antidotes / Q000008:administration & dosage* / Q000627:therapeutic use; D004338:Drug Combinations; D004569:Electroencephalography; D005486:Flavin Mononucleotide / Q000008:administration & dosage; D006801:Humans; D002534:Hypoxia, Brain / Q000139:chemically induced* / Q000188:drug therapy / Q000517:prevention & control*; D007290:Inosine Diphosphate / Q000008:administration & dosage; D018696:Neuroprotective Agents / Q000008:administration & dosage; D009536:Niacinamide / Q000008:administration & dosage; D011041:Poisoning / Q000188:drug therapy*; D012720:Severity of Illness Index; D013386:Succinates / Q000008:administration & dosage; D014803:Vitamin B Complex / Q000008:administration & dosage
chemical_list: D000931:Antidotes; D004338:Drug Combinations; D018696:Neuroprotective Agents; D013386:Succinates; C507879:cytoflavin; D014803:Vitamin B Complex; D009536:Niacinamide; D005486:Flavin Mononucleotide; D007290:Inosine Diphosphate