title: Incidence of amyotrophic lateral sclerosis in Sicily: A population based study.
abstract: Our objective was to investigate incidence of amyotrophic lateral sclerosis (ALS) in Sicily, southern Italy, by means of a population based study. We included people with ALS resident in five Sicilian provinces, whose onset occurred in the two-year period 2005-2006 (population at 31 December 2006: 3,481,096 inhabitants). A multisource case-finding procedure was adopted and patients were classified as affected by ALS according to revised El Escorial criteria. During the two-year surveillance period, 97 patients meeting eligibility criteria included 57 males (58.8%) and 40 females (41.2%). Crude annual incidence rate was 1.4/100,000 person years (95% CI 1.33-1.47). The incidence rate was higher in males (1.71/100,000; CI 1.61-1.81) than in females (1.11/100,000; CI 1.01-1.21). Standardized incidence rate for the total population in the 45-74-years-old age group was 3.22 (CI 3.11-3.33). Prevalence rate was 6.0/100,000 (CI 5.97-6.03), higher in males (7.1/100,000; CI 7.02-7.18) than females (4.9/100,000; CI 4.86-4.94). In conclusion, ALS rates observed in the present study are higher in males than females, with a peak of incidence at 70 years of age in both genders. These findings are consistent with those of other population based European studies.
authors.affiliation: Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche. paolo.ragonese@unipa.it
authors.forename: Paolo
authors.initials: P
authors.lastname: Ragonese
authors.forename: Eleonora
authors.initials: E
authors.lastname: Cellura
authors.forename: Paolo
authors.initials: P
authors.lastname: Aridon
authors.forename: Marco
authors.initials: M
authors.lastname: D'amelio
authors.forename: Rossella
authors.initials: R
authors.lastname: Spataro
authors.forename: Alfonsa Claudia
authors.initials: AC
authors.lastname: Taiello
authors.forename: Davide
authors.initials: D
authors.lastname: Maimone
authors.forename: Vincenzo
authors.initials: V
authors.lastname: La Bella
authors.forename: Giovanni
authors.initials: G
authors.lastname: Savettieri
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D000690:Amyotrophic Lateral Sclerosis / Q000175:diagnosis / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012727:Sex Characteristics; D012802:Sicily; D055815:Young Adult