title: Lifestyle habits and the risk of head and neck cancer in Zagreb region.
abstract: In 2002, International Agency for Research on Cancer launched a multicentric case-control study of head and neck cancer in 15 centres in 11 European countries, Croatia included. The Alcohol-related Cancers and Genetic Susceptibility in Europe (ARCAGE) study database with approximately 2500 case-control pairs is currently the largest head and neck cancer patients database in Europe. The aim of the present study was to estimate the risk of smoking and alcohol consumption in head and neck cancer patients from Zagreb region recruited in scope of the ARCAGE study. The cases (45 males, 9 females) and the controls (37 males, 9 females) were recruited from University Hospital Dubrava and Merkur University Hospital. A blood sample and a lifestyle questionnaire were collected from all study subjects. Data were analysed by logistic regression analysis. The distribution of cases was: 43 oral, 9 pharyngeal and 2 laryngeal cancer cases. Ever-smokers had a 4-fold higher cancer risk (adjusted OR 4.3 (CI 1.20-15.4)) compared to never-smokers. The adjusted odds ratio for alcohol consumption more than once a week was 4.1 (CI 1.5-11.2). The results are in keeping with previously published data from other countries.
authors.affiliation: Croatian National Institute of Public Health, Zagreb, Croatia. ariana.znaor@hzjz.hr
authors.forename: Ariana
authors.initials: A
authors.lastname: Znaor
authors.forename: Miso
authors.initials: M
authors.lastname: Virag
authors.forename: Tin
authors.initials: T
authors.lastname: Znaor
authors.forename: Spomenka
authors.initials: S
authors.lastname: Manojlović
authors.forename: Rajko
authors.initials: R
authors.lastname: Kusec
mesh_terms: D000428:Alcohol Drinking / Q000009:adverse effects; D017523:Croatia; D005260:Female; D005638:Fruit; D006258:Head and Neck Neoplasms / Q000209:etiology*; D006801:Humans; D008019:Life Style; D008297:Male; D008875:Middle Aged; D012306:Risk; D012907:Smoking / Q000009:adverse effects; D014675:Vegetables