title: A recent evaluation of the lethal potencies of ammodytoxins.
abstract: Ammodytoxin A (AtxA) is the most toxic secreted phospholipase A(2) of the three isotoxins with presynaptic neurotoxicity, isolated from the venom of the nose-horned viper (Vipera ammodytes ammodytes), with an LD(50) of 21 μg/kg in mice. The toxic potencies of two other isoforms have been re-evaluated using highly purified recombinant proteins, with their intraperitoneal LD(50)s determined as 960 μg/kg for AtxB and 310 μg/kg for AtxC. AtxB and AtxC differ from AtxA in only three and two amino acid residues, respectively.
authors.affiliation: Department of Chemistry and Biochemistry, Faculty of Chemistry and Chemical Technology, University of Ljubljana, Aškerčeva cesta 5, SI-1000 Ljubljana, Slovenia.
authors.forename: Petra
authors.initials: P
authors.lastname: Prijatelj-Žnidaršič
authors.forename: Jože
authors.initials: J
authors.lastname: Pungerčar
mesh_terms: D000818:Animals; D054501:Group II Phospholipases A2 / Q000633:toxicity*; D007928:Lethal Dose 50; D051379:Mice; D054467:Phospholipases A2 / Q000633:toxicity*; D014757:Viper Venoms / Q000633:toxicity*
chemical_list: D014757:Viper Venoms; C068117:ammodytoxin A; D054501:Group II Phospholipases A2; D054467:Phospholipases A2; C051125:ammodytoxin B; C060161:ammodytoxin C