title: A lupus-like reaction to subcutaneous interferon-α at injection sites.
abstract: Interferon-α has been associated with a wide range of adverse events (AEs). A lupus-like reaction at the injection site of subcutaneous (SC) interferon-α is exceptionally rare. A 60-year-old woman with recurrent metastatic melanoma repeatedly developed cutaneous lupus-like reactions at the SC interferon-α-2b injection sites on her thighs. Known features of lupus-like reactions at SC interferon-α injection sites are reviewed, and cutaneous injection site reactions to SC interferon-α are summarized.
authors.affiliation: The University of Texas-Houston Medical School, Houston, TX, USA.
authors.forename: Hubert M
authors.initials: HM
authors.lastname: Chodkiewicz
authors.forename: Philip R
authors.initials: PR
authors.lastname: Cohen
authors.forename: Kevin B
authors.initials: KB
authors.lastname: Kim
authors.forename: Doina
authors.initials: D
authors.lastname: Ivan
authors.forename: Jeffrey E
authors.initials: JE
authors.lastname: Gershenwald
mesh_terms: D003875:Drug Eruptions / Q000209:etiology*; D005260:Female; D006801:Humans; D007279:Injections, Subcutaneous; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage / Q000009:adverse effects*; D008178:Lupus Erythematosus, Cutaneous / Q000175:diagnosis*; D008545:Melanoma / Q000188:drug therapy / Q000473:pathology; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000009:adverse effects; D012878:Skin Neoplasms / Q000188:drug therapy / Q000473:pathology
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins