title: Electron paramagnetic resonance-based pH mapping using spectral-spatial imaging of sequentially scanned spectra.
abstract: The development of electron paramagnetic resonance (EPR)-based mapping of pH is an important advancement for the field of diagnostic imaging. The ability to accurately quantify pH change in vivo and monitor spatial distribution is desirable for the assessment of a number of pathological conditions in the human body as well as the monitoring of treatment response. In this work we introduce a method for EPR-based pH mapping utilizing a method of spectral-spatial imaging of sequentially scanned spectra to decrease the missing gradient rotation angle, without increasing the spatial field of view. Repeated in vitro measurements of pH phantom tubes demonstrated higher precision measurements of the hyperfine coupling constant (HFC) compared to previous EPR-based methods, resulting in mean pH values accurate to less than 0.1 pH across a range of physiologically observed values.
authors.affiliation: Division of Bioengineering and Bioinformatics, Graduate School of Information Science and Technology, Hokkaido University, Sapporo, Japan.
authors.forename: Shunichi
authors.initials: S
authors.lastname: Koda
authors.forename: Jonathan
authors.initials: J
authors.lastname: Goodwin
authors.forename: Valery V
authors.initials: VV
authors.lastname: Khramtsov
authors.forename: Hirotada
authors.initials: H
authors.lastname: Fujii
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Hirata
mesh_terms: D003952:Diagnostic Imaging; D004578:Electron Spin Resonance Spectroscopy; D006358:Hot Temperature; D006801:Humans; D006863:Hydrogen-Ion Concentration; D015394:Molecular Structure; D012680:Sensitivity and Specificity