title: [Effect of normobaric hyperoxia on the markers of bone tissue metabolism].
abstract: We studied the influencing of normobaric hyperoxia one hour daily during 14 and 28 days on the bone metabolism for 3- and 12-monthly Wistar male-rats (n =80). It was shown, that breathed normobaric gas mixture with 90% O2 during 14 days significant reducing of C-terminal propeptides of type I collagen levels for 36%, an increasing piridinolin levels for 37% and concentration of C-terminal telopeptides of type I collagen for 8% in the blood serum. We found reliable decreasing the concentration ofpiridinolin levels for 27% in adult rats in the same conditions. The C-terminal propeptides of type I collagen levels did not change in any of the groups' research. We believe that 14 days normobaric hyperoxia (90%) in young animals accompanied by violation of collagen synthesis. The adult rats were more stable and had no changes after influence the two hyperoxia levels.
authors.forename: V Ia
authors.initials: VIa
authors.lastname: Berezovs'kyĭ
authors.forename: T M
authors.initials: TM
authors.lastname: Zamors'ka
authors.forename: I H
authors.initials: IH
authors.lastname: Litovka
authors.forename: R V
authors.initials: RV
authors.lastname: Ianko
mesh_terms: D000375:Aging / Q000097:blood / Q000378:metabolism*; D000596:Amino Acids / Q000097:blood / Q000378:metabolism*; D000818:Animals; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D001846:Bone Development / Q000502:physiology; D001842:Bone and Bones / Q000378:metabolism*; D018496:Hyperoxia / Q000097:blood / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D010446:Peptide Fragments / Q000097:blood / Q000378:metabolism*; D011347:Procollagen / Q000097:blood / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000596:Amino Acids; D015415:Biomarkers; D010446:Peptide Fragments; D011347:Procollagen; C042813:procollagen type I carboxy terminal peptide; C015484:pyridinoline