title: Treatment of bleeding after kidney biopsy with recombinant activated factor VII.
abstract: Recombinant activated factor VII (rFVIIa) is approved for prevention and treatment of bleeding in hemophilia patients with inhibitors to FVIII (hemophilia A) or IX (hemophilia B), patients with congenital and acquired hemophilia and in patients with FVII deficiency or Glantzmann thrombasthenia (last indication is approved only in Europe). Off-labeled, the drug has been prescribed for prevention, or treatment of bleeding in severe hepatic disease, neonatal coagulopathies, high-risk surgical procedures, trauma, thrombocytopenia and platelet function disorders, as well as for urgent reversal of oral anticoagulation. Here we report a case of a 53-year-old female patient with delayed graft function after kidney transplantation, who had kidney biopsy complicated with prolonged bleeding. After unsuccessful treatment with desmopressin, the patient was treated with rFVIIa and the bleeding stopped immediately. Only few anecdotal reports of use of rFVIIa for treatment of bleeding in uremic patients have been published thus far. To our knowledge, this is the first case that describes use of rFVIIa for management of bleeding as a complication of renal biopsy in a uremic patient in the early kidney posttransplantation period.
authors.affiliation: Renal Division, Department of Medicine, University of Zagreb Medical School, Croatia.
authors.forename: Bojana
authors.initials: B
authors.lastname: Maksimovic
authors.forename: Ivan
authors.initials: I
authors.lastname: Neretljak
authors.forename: Zeljko
authors.initials: Z
authors.lastname: Vidas
authors.forename: I Kovacevic
authors.initials: IK
authors.lastname: Vojtusek
authors.forename: Katarina
authors.initials: K
authors.lastname: Tomulic
authors.forename: Mladen
authors.initials: M
authors.lastname: Knotek
mesh_terms: D001706:Biopsy / Q000009:adverse effects*; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D015942:Factor VIIa / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006470:Hemorrhage / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007668:Kidney / Q000473:pathology / Q000601:surgery; D007676:Kidney Failure, Chronic / Q000473:pathology / Q000601:surgery; D016030:Kidney Transplantation; D008875:Middle Aged; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000627:therapeutic use; D014511:Uremia / Q000097:blood
chemical_list: D011994:Recombinant Proteins; C103587:recombinant FVIIa; D015942:Factor VIIa; D003894:Deamino Arginine Vasopressin