title: Cycloartane triterpenoids from Cassia occidentalis.
abstract: A phytochemical investigation of the whole plants of Cassia occidentalis led to the isolation of two new cycloartane triterpenoids, cycloccidentalic acids A and B (1 and 2), and five new related saponins, cycloccidentalisides I-V (3-7), together with sixteen known compounds. The structures of the isolated compounds were elucidated through detailed spectroscopic analyses, including 1D and 2D NMR techniques, and chemical methods. Compounds 2 and 5 showed modest anti-HIV-1 activities with EC₅₀ values of 2.23 µM and 4.36 µM, respectively, in comparison to the positive control.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, P. R. China.
authors.forename: Shi-Fei
authors.initials: SF
authors.lastname: Li
authors.forename: Ying-Tong
authors.initials: YT
authors.lastname: Di
authors.forename: Rong-Hua
authors.initials: RH
authors.lastname: Luo
authors.forename: Yong-Tang
authors.initials: YT
authors.lastname: Zheng
authors.forename: Yue-Hu
authors.initials: YH
authors.lastname: Wang
authors.forename: Xin
authors.initials: X
authors.lastname: Fang
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Ling
authors.initials: L
authors.lastname: Li
authors.forename: Hong-Ping
authors.initials: HP
authors.lastname: He
authors.forename: Shun-Lin
authors.initials: SL
authors.lastname: Li
authors.forename: Xiao-Jiang
authors.initials: XJ
authors.lastname: Hao
mesh_terms: D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D012503:Saponins / Q000302:isolation & purification*; D029846:Senna Plant / Q000737:chemistry*; D014315:Triterpenes / Q000302:isolation & purification*
chemical_list: D012503:Saponins; D014315:Triterpenes; C085352:cycloartane