title: Terpenoids from the octocorals Menella sp. (Plexauridae) and Lobophytum crassum (Alcyonacea).
abstract: A new germacrane-type sesquiterpenoid, menelloide E (1), and a new cembrane-type diterpenoid, lobocrassin F (2), were isolated from the octocorals Menella sp. and Lobophytum crassum, respectively. The structures of terpenoids 1 and 2 were determined by spectroscopic and chemical methods and compound 2 was found to display a significant inhibitory effect on the release of elastase by human neutrophils.
authors.affiliation: Department of Biomedical Engineering, National Cheng Kung University, Tainan 701, Taiwan.|Department of Nutrition, HungKuang University, Taichung 433, Taiwan.|Department of Orthopedics, Taichung Veterans General Hospital, Taichung 407, Taiwan.
authors.forename: Cheng-Hung
authors.initials: CH
authors.lastname: Lee
authors.affiliation: Graduate Institute of Marine Biotechnology and Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan.|National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.
authors.forename: Chia-Ying
authors.initials: CY
authors.lastname: Kao
authors.affiliation: Graduate Institute of Marine Biotechnology and Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan.|National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.
authors.forename: Shih-Yao
authors.initials: SY
authors.lastname: Kao
authors.affiliation: Department of Biomedical Engineering, National Cheng Kung University, Tainan 701, Taiwan.
authors.forename: Chih-Han
authors.initials: CH
authors.lastname: Chang
authors.affiliation: Graduate Institute of Marine Biotechnology and Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan.|National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.|Department of Marine Biotechnology and Resources and Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
authors.forename: Jui-Hsin
authors.initials: JH
authors.lastname: Su
authors.affiliation: Graduate Institute of Natural Products, Chang Gung University, Taoyuan 333, Taiwan.
authors.forename: Tsong-Long
authors.identifier: 0000-0002-5780-3977
authors.initials: TL
authors.lastname: Hwang
authors.affiliation: School of Chinese Pharmaceutical Sciences and Chinese Medicine Resources and Tsuzuki Institute for Traditional Medicine, College of Pharmacy, China Medical University, Taichung 404, Taiwan.
authors.forename: Yueh-Hsiung
authors.identifier: 0000-0001-5935-6755
authors.initials: YH
authors.lastname: Kuo
authors.affiliation: Department of Marine Biotechnology and Resources and Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
authors.forename: Zhi-Hong
authors.identifier: 0000-0003-4411-044X
authors.initials: ZH
authors.lastname: Wen
authors.affiliation: Graduate Institute of Marine Biotechnology and Department of Life Science and Institute of Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan.|National Museum of Marine Biology and Aquarium, Pingtung 944, Taiwan.|Department of Marine Biotechnology and Resources and Division of Marine Biotechnology, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
authors.forename: Ping-Jyun
authors.identifier: 0000-0002-6644-9236
authors.initials: PJ
authors.lastname: Sung
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000378:metabolism*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology*; D017756:Aquaculture; D045424:Complex Mixtures / Q000737:chemistry / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D055808:Drug Discovery; D056727:Endangered Species; D006801:Humans; D019272:Leukocyte Elastase / Q000378:metabolism; D015394:Molecular Structure; D018375:Neutrophil Activation / Q000187:drug effects; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D010140:Pacific Ocean; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D013237:Stereoisomerism; D013624:Taiwan; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D045424:Complex Mixtures; D004224:Diterpenes; D012717:Sesquiterpenes; D013729:Terpenes; C573584:lobocrassin F; C573583:menelloide E; D019272:Leukocyte Elastase