title: Allergy as an epithelial barrier disease.
abstract: The objective of this review is to focus on putative modified epithelial functions related to allergy. The dysregulation of the epithelial barrier might result in the allergen uptake, which could be the primary defect in the pathogenesis of allergic reaction. We review the literature of the role of respiratory epithelium as an active barrier, how allergens are transported through it and how it senses the hostile environmental allergens and other dangerous stimuli.
authors.affiliation: Transplantation Laboratory & Infection Biology Research Program, Haartman Institute, University of Helsinki & Helsinki University Central Hospital, HUSLAB, Helsinki, Finland. risto.renkonen@helsinki.fi.
authors.forename: Pirkko
authors.initials: P
authors.lastname: Mattila
authors.forename: Sakari
authors.initials: S
authors.lastname: Joenväärä
authors.forename: Jutta
authors.initials: J
authors.lastname: Renkonen
authors.forename: Sanna
authors.initials: S
authors.lastname: Toppila-Salmi
authors.forename: Risto
authors.initials: R
authors.lastname: Renkonen