title: Histological findings of birdshot chorioretinopathy in an eye with ciliochoroidal melanoma.
abstract: OBJECTIVE
  To describe the histological findings of birdshot chorioretinopathy. DESIGN/PARTICIPANT: This is a case study of a single patient who has both birdshot chorioretinopathy and ciliochoroidal melanoma.
  
  
  METHODS
  A 55-year-old woman who was HLA-A29 positive and had birdshot chorioretinopathy had a large ciliochoroidal melanoma (T4b N0 M0) and underwent enucleation.
  
  
  METHODS
  Using histopathology, we hope to further define the pathological findings in an eye with both birdshot chorioretinopathy and coexistant ciliochoroidal melanomas.
  
  
  RESULTS
  The eye showed a ciliochoroidal melanoma. In addition, elsewhere, there were multiple choroidal nodules of lymphocytes that showed the presence of CD3-positive cells, which also stained for CD4 or CD8. There were only a few CD20-positive B cells and rare CD68-positive histiocytes. No granulomas were present.
  
  
  CONCLUSIONS
  To our knowledge, there are only two previous reports describing the histological findings in birdshot chorioretinopathy: one that was HLA-A29 negative showing choroidal granulomas and another that was HLA-A29 positive exhibiting histological findings similar to our case. Incidentally, the latter case had a history of cutaneous melanoma.
  
  
  CONCLUSIONS
  Birdshot chorioretinopathy is a nongranulomatous nodular infiltration of the choroid.
authors.affiliation: Department of Ophthalmology, Mayo Clinic, Rochester, MN 55902, USA. pulido.jose@mayo.edu
authors.forename: J S
authors.initials: JS
authors.lastname: Pulido
authors.forename: I
authors.initials: I
authors.lastname: Canal
authors.forename: D
authors.initials: D
authors.lastname: Salomão
authors.forename: D
authors.initials: D
authors.lastname: Kravitz
authors.forename: E
authors.initials: E
authors.lastname: Bradley
authors.forename: R
authors.initials: R
authors.lastname: Vile
mesh_terms: D000080365:Birdshot Chorioretinopathy; D002825:Chorioretinitis / Q000150:complications / Q000276:immunology / Q000473:pathology*; D002830:Choroid Neoplasms / Q000150:complications / Q000473:pathology*; D004396:Coloring Agents; D015353:Eye Enucleation; D005260:Female; D005451:Fluorescein Angiography; D015234:HLA-A Antigens / Q000276:immunology; D006801:Humans; D007208:Indocyanine Green; D008545:Melanoma / Q000150:complications / Q000473:pathology*; D008875:Middle Aged; D014792:Visual Acuity
chemical_list: D004396:Coloring Agents; D015234:HLA-A Antigens; C035524:HLA-A29 antigen; D007208:Indocyanine Green