title: Palladium-catalyzed N-arylation of 2-aminothiazoles.
abstract: A method for the Pd-catalyzed coupling of 2-aminothiazole derivatives with aryl bromides and triflates is described. Significantly, for this class of nucleophiles, the coupling exhibits a broad substrate scope and proceeds with a reasonable catalyst loading. Furthermore, an interesting effect of acetic acid as an additive is uncovered that facilitates catalyst activation.
authors.affiliation: Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
authors.forename: Meredeth A
authors.initials: MA
authors.lastname: McGowan
authors.forename: Jaclyn L
authors.initials: JL
authors.lastname: Henderson
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Buchwald
mesh_terms: D002384:Catalysis; D006842:Hydrocarbons, Brominated / Q000737:chemistry; D008698:Mesylates / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013844:Thiazoles / Q000737:chemistry*
chemical_list: D006842:Hydrocarbons, Brominated; D008698:Mesylates; D013844:Thiazoles; C004483:2-aminothiazole; D010165:Palladium