title: Aluminium phosphide poisoning and oxidative stress: serum biomarker assessment.
abstract: According to previous animal studies, aluminium phosphides (AlPs) may induce oxidative stress leading to generation of free radicals and alteration in antioxidant defense system. This study was conducted to evaluate the existence and degree of oxidative stress in patients with acute AlP ingestion. A total of 44 acute AlP ingested patients as well as 44 age- and sex-matched controls were included. All patients had acute poisoning symptoms with AlP at the time of presentation and had blood samples analyzed for lipid peroxidation, total antioxidant capacity and total thiol. Our findings showed that there is a significant increase in lipid peroxidation in AlP ingested group along with a reduction in total antioxidant capacity and total thiols groups. These clinical data confirm previous experimental models that showed AlP exposure might significantly augment lipoperoxidative damage with simultaneous alterations in the antioxidant defense system. Hence, our findings might justify use of antioxidants in treatment of acute AlP poisoning which needs to be clarified by additional clinical trials.
authors.affiliation: Emergency Department, Imam Hossein Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Hamid
authors.initials: H
authors.lastname: Kariman
authors.forename: Kamran
authors.initials: K
authors.lastname: Heydari
authors.forename: Mohammad
authors.initials: M
authors.lastname: Fakhri
authors.forename: Ali
authors.initials: A
authors.lastname: Shahrami
authors.forename: Ali Arhami
authors.initials: AA
authors.lastname: Dolatabadi
authors.forename: Hossein Ali
authors.initials: HA
authors.lastname: Mohammadi
authors.forename: Morteza
authors.initials: M
authors.lastname: Gharibi
mesh_terms: D000328:Adult; D017607:Aluminum Compounds / Q000506:poisoning*; D000975:Antioxidants / Q000032:analysis; D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D007492:Iran; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D010720:Phosphines / Q000506:poisoning*; D013438:Sulfhydryl Compounds / Q000097:blood
chemical_list: D017607:Aluminum Compounds; D000975:Antioxidants; D015415:Biomarkers; D005609:Free Radicals; D010720:Phosphines; D013438:Sulfhydryl Compounds; C001864:aluminum phosphide