title: Fragrance material review on 2-methyl-4-phenyl-2-butyl acetate.
abstract: A toxicologic and dermatologic review of 2-methyl-4-phenyl-2-butyl acetate when used as a fragrance ingredient is presented. 2-Methyl-4-phenyl-2-butyl acetate is a member of the fragrance structural group Aryl Alkyl Alcohol Simple Acid Esters (AAASAE). The AAASAE fragrance ingredients are prepared by reacting an aryl alkyl alcohol with a simple carboxylic acid (a chain of 1-4 carbons) to generate formate, acetate, propionate, butyrate, isobutyrate and carbonate esters. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for 2-methyl-4-phenyl-2-butyl acetate were evaluated then summarized and includes physical properties, acute toxicity, skin irritation, skin sensitization, and elicitation data. A safety assessment of the entire AAASAE will be published simultaneously with this document. Please refer to Belsito et al. (2012) for an overall assessment of the safe use of this material and all AAASAE in fragrances.
authors.affiliation: Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA. dmcginty@RIFM.org
authors.forename: D
authors.initials: D
authors.lastname: McGinty
authors.forename: C S
authors.initials: CS
authors.lastname: Letizia
authors.forename: A M
authors.initials: AM
authors.lastname: Api
mesh_terms: D000085:Acetates / Q000493:pharmacokinetics / Q000633:toxicity*; D000818:Animals; D006801:Humans; D051379:Mice; D010476:Perfume; D011817:Rabbits; D012867:Skin / Q000187:drug effects; D018675:Toxicity Tests
chemical_list: D000085:Acetates; D010476:Perfume; C577722:2-methyl-4-phenyl-2-butyl acetate