title: Newly emerging clones of Bordetella pertussis carrying prn2 and ptxP3 alleles implicated in Australian pertussis epidemic in 2008-2010.
abstract: Australia is experiencing a prolonged epidemic of pertussis that began in 2008. A total of 194 Bordetella pertussis isolates collected from 2008 through 2010 were typed by single-nucleotide polymorphism (SNP) analysis, by multilocus variable number tandem repeats analysis, and by fim3, prn, and ptxP sequence analyses. Strains with 2 closely related SNP profiles carrying prn2 and ptxP3 from the recently emerged SNP cluster I predominated. The data suggest increasing selection among the B. pertussis population in Australia in favor of strains carrying prn2 and ptxP3 under the pressure of acellular vaccine-induced immunity.
authors.affiliation: School of Biotechnology and Biomolecular Sciences, University of New South Wales, Australia.
authors.forename: Sophie
authors.initials: S
authors.lastname: Octavia
authors.forename: Vitali
authors.initials: V
authors.lastname: Sintchenko
authors.forename: Gwendolyn L
authors.initials: GL
authors.lastname: Gilbert
authors.forename: Andrew
authors.initials: A
authors.lastname: Lawrence
authors.forename: Anthony D
authors.initials: AD
authors.lastname: Keil
authors.forename: Geoff
authors.initials: G
authors.lastname: Hogg
authors.forename: Ruiting
authors.initials: R
authors.lastname: Lan
mesh_terms: D000483:Alleles; D001315:Australia / Q000453:epidemiology; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D001886:Bordetella pertussis / Q000235:genetics*; D058872:Epidemics; D015964:Gene Expression Regulation, Bacterial / Q000502:physiology; D006801:Humans; D011110:Polymorphism, Genetic; D014917:Whooping Cough / Q000453:epidemiology* / Q000382:microbiology*
chemical_list: D001426:Bacterial Proteins