title: [Thromboembolic complications of childhood nephrotic syndrome].
abstract: BACKGROUND
  Vascular thrombosis in the childhood nephrotic syndrome is a rare event. It poses major diagnostic and therapeutic problems. The prognosis depends on early diagnosis and on precocious anticoagulation. The risk of extension of thrombosis and pulmonary embolism is real.
  
  
  OBJECTIVE
  To consider the major thrombotic events associated with childhood nephrotic syndrome and to establish an appropriate preventive approach based on objective clinical and laboratory parameters.
  
  
  METHODS
  This is a retrospective study of all cases of patients suffering from idiopathic nephrotic syndrome, during a period of 20 years, starting from January 1990 to December 2009. We selected six patients with vascular thrombosis. The diagnosis was confirmed by appropriate radiological investigation.
  
  
  RESULTS
  Six cases of vascular thrombosis were identified among 260 cases of nephrotic syndrome collected during the period study. Patients are divided into five boys and one girl. The mean age was 13.3 years. The localisation of thrombosis is venous in all cases. One patient presented a massively fatal pulmonary embolism. Sinovenous thrombosis has been objectified in 3 patients who were all treated with a good therapeutic response.
  
  
  CONCLUSIONS
  vascular thrombosis remains one of the most serious complications of nephrotic syndrome in children. Early diagnosis and precocious anticoagulation are essential for preventing the extension of thrombosis.
authors.affiliation: Hopital Charles Nicolle, Tunis, Tunisie.
authors.forename: Tahar
authors.initials: T
authors.lastname: Gargah
authors.forename: Kamal
authors.initials: K
authors.lastname: Abidi
authors.forename: Khelil
authors.initials: K
authors.lastname: Nourchene
authors.forename: Chokri
authors.initials: C
authors.lastname: Zarrouk
authors.forename: Mohamed R
authors.initials: MR
authors.lastname: Lakhoua
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D009404:Nephrotic Syndrome / Q000150:complications*; D011655:Pulmonary Embolism / Q000209:etiology; D012189:Retrospective Studies; D020246:Venous Thrombosis / Q000209:etiology*