title: Soluble human leukocyte antigen-G expression in patients with ductal and lobular breast malignancy.
abstract: BACKGROUND
  Human leukocyte antigen-G (HLA-G) has been closely associated with diagnosis and prognosis in many types of human cancer. The current study aims to investigate soluble (s) HLA-G expression in patients with breast malignancy.
  
  
  METHODS
  sHLA-G plasma expression was determined in 120 patients with breast cancer and 40 healthy controls using enzyme-linked immunosorbent assay.
  
  
  RESULTS
  Plasma sHLA-G levels were significantly higher in breast cancer patients compared to healthy controls (p<0.001), with an area under the receiver operating characteristic (ROC) curve of 0.735 (95% Confidence interval=0.630-0.841, p<0.001). Significantly increased sHLA-G expression was detected in patients with mixed type of coexisting ductal and lobular breast lesions, compared to patients with pure ductal carcinoma or pure lobular neoplasia (p<0.05).
  
  
  CONCLUSIONS
  sHLA-G expression is closely associated with the histological type of breast cancer. Our findings support the application of sHLA-G as a potential biomarker in body fluids for preoperative breast cancer detection and diagnosis.
authors.affiliation: Research Center, Hellenic Anticancer Institute, 11 Valtetsiou St., Athens 10680, Greece.
authors.forename: Xeni
authors.initials: X
authors.lastname: Provatopoulou
authors.forename: Eleni
authors.initials: E
authors.lastname: Kalogera
authors.forename: Alexandros
authors.initials: A
authors.lastname: Sagkriotis
authors.forename: Flora
authors.initials: F
authors.lastname: Zagouri
authors.forename: Aphroditi
authors.initials: A
authors.lastname: Nonni
authors.forename: George C
authors.initials: GC
authors.lastname: Zografos
authors.forename: Antonia
authors.initials: A
authors.lastname: Gounaris
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000235:genetics* / Q000276:immunology; D018270:Carcinoma, Ductal, Breast / Q000235:genetics* / Q000276:immunology; D018275:Carcinoma, Lobular / Q000235:genetics* / Q000276:immunology; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D059951:HLA-G Antigens / Q000097:blood / Q000235:genetics*; D006801:Humans; D008875:Middle Aged
chemical_list: D059951:HLA-G Antigens