title: o-Iodoxybenzoic acid mediated oxidative desulfurization initiated domino reactions for synthesis of azoles.
abstract: A systematic exploration of thiophilic ability of o-iodoxybenzoic acid (IBX) for oxidative desulfurization to trigger domino reactions leading to new methodologies for synthesis of different azoles is described. A variety of highly substituted oxadiazoles, thiadiazoles, triazoles, and tetrazoles have been successfully synthesized in good to excellent yields, starting from readily accessible thiosemicarbazides, bis-diarylthiourea, 1,3-disubtituted thiourea, and thioamides.
authors.affiliation: Department of Pharmaceutical Sciences and Technology, Institute of Chemical Technology, Matunga, Mumbai 400 019, India.
authors.forename: Pramod S
authors.initials: PS
authors.lastname: Chaudhari
authors.forename: Sagar P
authors.initials: SP
authors.lastname: Pathare
authors.forename: Krishnacharaya G
authors.initials: KG
authors.lastname: Akamanchi
mesh_terms: D001393:Azoles / Q000138:chemical synthesis* / Q000737:chemistry*; D007462:Iodobenzenes / Q000737:chemistry*; D008956:Models, Chemical; D009584:Nitrogen / Q000737:chemistry*; D010084:Oxidation-Reduction; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000737:chemistry; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001393:Azoles; D007462:Iodobenzenes; D013830:Thiadiazoles; D014230:Triazoles; C476101:o-iodoxybenzoic acid; D009584:Nitrogen