title: Clonality in gynecologic neoplasms: is it time to reevaluate clonality studies in gynecologic neoplasms? Is it possible to confirm multicentricity with clonality studies?
abstract: This article reviews issues with clonality applied to gynecologic neoplasms. It is our opinion that the current interpretation of clonality studies in gynecologic neoplasms needs to be reevaluated because multicentricity, probably a common mechanism of tumor development in gynecology, cannot be confirmed with clonality.
authors.affiliation: Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, USA. esilva@mdanderson.org
authors.forename: Elvio G
authors.initials: EG
authors.lastname: Silva
authors.forename: Xavier
authors.initials: X
authors.lastname: Matias-Guiu
mesh_terms: D002471:Cell Transformation, Neoplastic / Q000235:genetics; D003937:Diagnosis, Differential; D005260:Female; D005833:Genital Neoplasms, Female / Q000235:genetics* / Q000473:pathology; D006801:Humans; D009362:Neoplasm Metastasis / Q000175:diagnosis / Q000235:genetics*; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis / Q000235:genetics*