title: [New glioma therapy using specific microRNAs].
abstract: Recent research has revealed the existence of a class of small non-coding RNAs, known as microRNAs. These microRNAs are deregulated in various cancers including gliomas. MicroRNAs have been suggested to be important in cancer stem cell biology and in proliferation and chemosensitivity of cancer cells. This makes microRNAs obvious targets for novel therapeutic strategies. In the present article we focus on the role of microRNAs in cancer cells and cancer stem cells as well as the possible therapeutic approaches exploiting this knowledge to improve future glioma therapy.
authors.affiliation: Neurokirurgisk Afdeling, Odense Universitetshospital, Sdr. Boulevard 29, 5000 Odense C, Denmark. bo.halle@ouh.regionsyddanmark.dk
authors.forename: Bo
authors.initials: B
authors.lastname: Halle
authors.forename: Claus
authors.initials: C
authors.lastname: Andersen
authors.forename: Mette Katrine
authors.initials: MK
authors.lastname: Schulz
authors.forename: Bjarne Winther
authors.initials: BW
authors.lastname: Kristensen
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000235:genetics; D018481:Convection; D016503:Drug Delivery Systems / Q000379:methods; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D005909:Glioblastoma / Q000188:drug therapy / Q000235:genetics; D005910:Glioma / Q000188:drug therapy* / Q000235:genetics; D006801:Humans; D035683:MicroRNAs / Q000187:drug effects / Q000235:genetics* / Q000502:physiology; D014411:Neoplastic Stem Cells / Q000187:drug effects / Q000502:physiology
chemical_list: D000970:Antineoplastic Agents; D035683:MicroRNAs