title: Evaluation of the anti-oxidant properties of a SOD-mimic Mn-complex in activated macrophages.
abstract: SOD-mimics are small complexes that reproduce the activity of superoxide dismutases, natural proteins that catalytically dismutate the superoxide anion. Activated macrophages, which produce ROS and RNS fluxes, constitute a relevant model to challenge antioxidant activity in a cellular context and were used to test a Mn-complex which was shown to efficiently alter the flow of O(2)(-), ONOO(-) and H(2)O(2).
authors.affiliation: Ecole Normale Supérieure, Département de chimie, Paris, France.
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Bernard
authors.forename: Claire
authors.initials: C
authors.lastname: Giroud
authors.forename: H Y Vincent
authors.initials: HY
authors.lastname: Ching
authors.forename: Anne
authors.initials: A
authors.lastname: Meunier
authors.forename: Vinita
authors.initials: V
authors.lastname: Ambike
authors.forename: Christian
authors.initials: C
authors.lastname: Amatore
authors.forename: Manon Guille
authors.initials: MG
authors.lastname: Collignon
authors.forename: Frédéric
authors.initials: F
authors.lastname: Lemaître
authors.forename: Clotilde
authors.initials: C
authors.lastname: Policar
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D040761:Biomimetic Materials / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D045304:Cytochromes c / Q000378:metabolism; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism; D008345:Manganese / Q000737:chemistry*; D051379:Mice; D009942:Organometallic Compounds / Q000737:chemistry / Q000494:pharmacology*; D026361:Reactive Nitrogen Species / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D016897:Respiratory Burst / Q000187:drug effects; D013482:Superoxide Dismutase / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D009942:Organometallic Compounds; D026361:Reactive Nitrogen Species; D017382:Reactive Oxygen Species; D008345:Manganese; D045304:Cytochromes c; D013482:Superoxide Dismutase