title: Heparin-induced thrombocytopenia in essential thrombocytosis.
abstract: We report a 67-year-old woman with essential thrombocytosis who developed cerebral infarction and heparin-induced thrombocytopenia during treatment for the cerebral infarction. She developed additional cerebral infarcts, acute femoral artery occlusion, and thrombophlebitis of her lower extremities. She was successfully treated with argatroban. This is the first report of a patient with essential thrombocytosis who developed heparin-induced thrombocytopenia and serious conditions, which included multiple thromboembolisms and coagulation disorders mimicking disseminated intravascular coagulation.
authors.affiliation: Department of Neurology, Tottori Prefectural Central Hospital, Tottori, Japan.
authors.forename: Ayumi
authors.initials: A
authors.lastname: Murawaki
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nakayasu
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Doi
authors.forename: Kaori
authors.initials: K
authors.lastname: Suzuki-Kinoshita
authors.forename: Yasumasa
authors.initials: Y
authors.lastname: Asai
authors.forename: Hiromi
authors.initials: H
authors.lastname: Omura
authors.forename: Kenji
authors.initials: K
authors.lastname: Nakashima
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000009:adverse effects* / Q000627:therapeutic use; D001120:Arginine / Q000031:analogs & derivatives; D001157:Arterial Occlusive Diseases / Q000175:diagnosis / Q000209:etiology; D001856:Bone Marrow Examination; D002544:Cerebral Infarction / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D003251:Constriction, Pathologic; D003937:Diagnosis, Differential; D004211:Disseminated Intravascular Coagulation / Q000175:diagnosis; D005260:Female; D005263:Femoral Artery; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging; D010875:Pipecolic Acids / Q000627:therapeutic use; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D010976:Platelet Count; D011237:Predictive Value of Tests; D013449:Sulfonamides; D013920:Thrombocythemia, Essential / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D013924:Thrombophlebitis / Q000175:diagnosis / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D000925:Anticoagulants; D010875:Pipecolic Acids; D010975:Platelet Aggregation Inhibitors; D013449:Sulfonamides; D006493:Heparin; D001120:Arginine; C031942:argatroban