title: [Macrolide resistance in Mycoplasma pneumoniae by recurrence and extended illness].
abstract: A 36 year-old female with a Mycoplasma pneumoniae (MP) infection was treated with azithromycin. She recovered transitory, but experienced a relapse a few days later. After ten days she visited her general practitioner again; she was tired and weakened, had a debilitating dry cough and a weight loss of 6 kg. A throat swab was positive for MP by a polymerase chain reaction (PCR). It was investigated by sequencing and a mutation corresponding to a A2063G transition in domain V of the 23S rRNA known to be associated with macrolide resistance was detected. Twenty-two days later, MP could still be detected by PCR on a nasopharyngeal secretion.
authors.affiliation: Afdeling for Mikrobiologisk Diagnostik og Forskning, Statens Serum Institut, Artillerivej 5, 2300 København S, Denmark. su@ssi.dk
authors.forename: Søren Anker
authors.initials: SA
authors.lastname: Uldum
authors.forename: Paul
authors.initials: P
authors.lastname: Amberg
authors.forename: Jørgen Skov
authors.initials: JS
authors.lastname: Jensen
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D017963:Azithromycin / Q000008:administration & dosage / Q000627:therapeutic use*; D024881:Drug Resistance, Bacterial; D005260:Female; D006801:Humans; D009177:Mycoplasma pneumoniae / Q000187:drug effects* / Q000235:genetics; D011019:Pneumonia, Mycoplasma / Q000188:drug therapy*; D016133:Polymerase Chain Reaction; D012008:Recurrence
chemical_list: D000900:Anti-Bacterial Agents; D017963:Azithromycin