title: Health related quality of life and impact of infectious comorbidity in outpatient management of patients with acute leukemia.
abstract: Although survival has improved among patients with acute leukemia, there is still a considerable risk of severe complications throughout the course of treatment. This contrast increases the interest in monitoring health related quality of life (HRQOL) in these patients. This study presents a longitudinal HRQOL evaluation (European Organisation for Research and Treatment of Cancer core 30-item questionnaire; EORTC-QLQ C-30) and the impact of infectious comorbidity among 60 patients with leukemia (median age 47) treated in an outpatient management program at Copenhagen University Hospital. Significant improvement was seen on several HRQOL scores during follow-up. Explorative general linear models (GLMs) suggest that high cumulative severity of infectious comorbidity significantly reduces physical functioning and overall quality of life at treatment completion.
authors.affiliation: UCSF, The University Hospital's Center for Nursing and Care Research, Copenhagen, Denmark. tom@ucsf.dk
authors.forename: Tom
authors.initials: T
authors.lastname: Møller
authors.forename: Lis
authors.initials: L
authors.lastname: Adamsen
authors.forename: Charlotte
authors.initials: C
authors.lastname: Appel
authors.forename: Pernille
authors.initials: P
authors.lastname: Welinder
authors.forename: Maria
authors.initials: M
authors.lastname: Stage
authors.forename: Mary
authors.initials: M
authors.lastname: Jarden
authors.forename: Maiken
authors.initials: M
authors.lastname: Hjerming
authors.forename: Lars
authors.initials: L
authors.lastname: Kjeldsen
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000553:Ambulatory Care; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D003141:Communicable Diseases / Q000453:epidemiology*; D015897:Comorbidity; D005260:Female; D006801:Humans; D007938:Leukemia / Q000188:drug therapy / Q000453:epidemiology* / Q000523:psychology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011788:Quality of Life; D055815:Young Adult