title: Human T-cell leukemia virus type 1 infection worsens prognosis of hepatitis C virus-related living donor liver transplantation.
abstract: Severe and life-threatening donor-transmitted human T-cell leukemia virus type 1 (HTLV-1) infections after solid organ transplantation have been reported. However, in HTLV-1-infected recipients, graft and patient survival were not fully evaluated. A total of 140 patients underwent living donor liver transplantation (LDLT). Of these, 47 of 126 adult recipients showed indications of hepatitis C virus (HCV)-related liver disease. The HTLV-1 prevalence rate was 10 of 140 recipients (7.14%) and three of 140 donors (0.02%). In HCV-related LDLT, graft and patient survival was worsened by HTLV-1 infection in recipients (seven cases). The 1-, 3-, and 5-year survival rates in the HCV/HTLV-1-co-infected group were 67%, 32%, and 15%, respectively, and the corresponding rates in the HCV-mono-infected group were 80%, 67%, and 67%, respectively. Only the 5-year survival rates were statistically significant (P=0.04, log-rank method). HTLV-1 infection in recipients is also an important factor in predicting survival in HTLV-1 endemic areas.
authors.affiliation: Department of Gastroenterology and Hepatology, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan. ichikawa@net.nagasaki-u.ac.jp
authors.forename: Tatsuki
authors.initials: T
authors.lastname: Ichikawa
authors.forename: Naota
authors.initials: N
authors.lastname: Taura
authors.forename: Hisamitsu
authors.initials: H
authors.lastname: Miyaaki
authors.forename: Toshihisa
authors.initials: T
authors.lastname: Matsuzaki
authors.forename: Masashi
authors.initials: M
authors.lastname: Ohtani
authors.forename: Susumu
authors.initials: S
authors.lastname: Eguchi
authors.forename: Mitsuhisa
authors.initials: M
authors.lastname: Takatsuki
authors.forename: Akihisa
authors.initials: A
authors.lastname: Soyama
authors.forename: Masaaki
authors.initials: M
authors.lastname: Hidaka
authors.forename: Sadayuki
authors.initials: S
authors.lastname: Okudaira
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Usui
authors.forename: Sayaka
authors.initials: S
authors.lastname: Mori
authors.forename: Shimeru
authors.initials: S
authors.lastname: Kamihira
authors.forename: Takashi
authors.initials: T
authors.lastname: Kanematsu
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Nakao
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006085:Graft Survival; D015490:HTLV-I Infections / Q000150:complications*; D016174:Hepacivirus / Q000276:immunology; D006526:Hepatitis C / Q000150:complications* / Q000453:epidemiology / Q000821:virology; D006801:Humans; D007564:Japan / Q000453:epidemiology; D016031:Liver Transplantation / Q000401:mortality*; D019520:Living Donors; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome