title: The black agonist-receptor model of high potency sweeteners, and its implication to sweetness taste and sweetener design.
abstract: The dose responses of the most commonly used high potency sweeteners (HPSs) have been measured by a more precise sensory procedure. The data were analyzed by Black's pharmacological model that takes into account not only agonist binding affinity but transduction efficiency as well. HPSs are clearly segregated into 2 groups depending on whether they bind to T1R2 or T1R3 of the receptor heterodimer. Surprisingly, the more potent sweeteners have lower transduction efficiencies. The implications of these on consumer product development and HPS design are discussed.
authors.affiliation: A & Y Kutató Intézet, Budapest, Hungary. ordasfarkas@gate.net
authors.forename: Attila
authors.initials: A
authors.lastname: Farkas
authors.forename: János
authors.initials: J
authors.lastname: Híd
mesh_terms: D001218:Aspartame / Q000032:analysis; D002352:Carrier Proteins / Q000378:metabolism; D016208:Databases, Factual; D006801:Humans; D008958:Models, Molecular; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D012439:Saccharin / Q000032:analysis; D013549:Sweetening Agents / Q000378:metabolism*; D013649:Taste / Q000502:physiology*
chemical_list: D002352:Carrier Proteins; D043562:Receptors, G-Protein-Coupled; D013549:Sweetening Agents; C431926:taste receptors, type 1; D012439:Saccharin; D001218:Aspartame