title: From metabolic normality to cardiometabolic risk factors in subjects with obesity.
abstract: The aim of the study was to evaluate the 3 years incidence of cardiometabolic risk factors, such as impaired fasting glucose, reduced high-density lipoprotein (HDL)-cholesterol, increased plasma triglycerides or blood pressure as well as impaired glucose tolerance in overweight or obese (ow/ob) and normal body weight (nbw) subjects metabolically normal at baseline. Subjects from the Relationship between Insulin Sensitivity and Cardiovascular Disease (RISC) study were analyzed. We analyzed 284 nbw and 152 ow/ob subjects who, at baseline, did not show any of the above-mentioned cardiometabolic risk factors. At 3 years, these parameters were re-evaluated. Intima-media thickness (IMT) of the common carotid artery (CCA) was echographically measured. At follow-up, the incidence of one or more cardiometabolic risk factors was 57.2% in ow/ob vs. 31.7% in nbw (P < 0.0001). After adjustment for age, sex, menopause status, lifestyle parameters, insulin sensitivity, and fasting insulinemia, BMI remained significantly linked to the development of one or more cardiometabolic risk factors (P = 0.02). An increased BMI at follow-up was significantly associated with the development of cardiometabolic alterations, in both nbw and ow/ob groups (P = 0.04). Ow/ob subjects who, at 3 years follow-up, remained metabolically normal, showed a less favourable cardiometabolic profile, when compared to nbw counterparts. In ow/ob metabolically normal males and females, intima-media of the common carotid at follow-up was thicker than in nbw (P = 0.03 for males, P = 0.04 for females). In conclusion, metabolically normal obese subjects show a higher incidence of cardiometabolic risk factors, in a short follow-up period. Weight gain is significantly associated with the development of these factors, in both nbw and ow/ob subjects.
authors.affiliation: Service of Therapeutic Education for Chronic Diseases, WHO Collaborating Centre, Geneva University Hospital, Geneva, Switzerland.
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Bobbioni-Harsch
authors.forename: Zoltan
authors.initials: Z
authors.lastname: Pataky
authors.forename: Vincent
authors.initials: V
authors.lastname: Makoundou
authors.forename: Martine
authors.initials: M
authors.lastname: Laville
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Disse
authors.forename: Christian
authors.initials: C
authors.lastname: Anderwald
authors.forename: Thomas
authors.initials: T
authors.lastname: Konrad
authors.forename: Alain
authors.initials: A
authors.lastname: Golay
mesh_terms: D000328:Adult; D001794:Blood Pressure; D015992:Body Mass Index; D001835:Body Weight; D002318:Cardiovascular Diseases / Q000097:blood* / Q000209:etiology / Q000503:physiopathology; D017536:Carotid Artery, Common / Q000503:physiopathology*; D059168:Carotid Intima-Media Thickness; D005215:Fasting / Q000097:blood; D005260:Female; D018149:Glucose Intolerance / Q000097:blood*; D006801:Humans; D007333:Insulin Resistance; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D012016:Reference Values; D012307:Risk Factors; D055815:Young Adult
chemical_list: D008075:Lipoproteins, HDL