title: [Relativity in multiple myeloma and KL-6].
abstract: KL-6 is a high-molecular-weight mucinous glycoprotein discovered as a pulmonary adenocaricinoma related antigen. Its levels are used as a biomarker of lung injury in interstitial pneumonia. We here report a case of multiple myeloma with Bence-Jones lambda type whose serum KL-6 level was revealed high at a concentration of 19,400 U/ml. Next, we analyzed the blood test profiles and the concentrations of KL-6 in 20 patients with multiple myeloma. CD19/CD56 double negative fraction on myeloma cells with high expression of CD38 was found in all 5 patients with multiple myeloma having elevated KL-6 level. Patients with interstitial pneumonia show high level of KL-6. We, therefore, need to differentiate the interstitial pneumonia and the above-mentioned multiple myeloma when serum KL-6 level is high.
authors.affiliation: Central Clinical Laboratory, Shimane University Hospital, Izumo 693-8501, Japan. matsuda8@med.shimane-u.ac.jp
authors.forename: Chikashi
authors.initials: C
authors.lastname: Matsuda
authors.forename: Takaaki
authors.initials: T
authors.lastname: Miyake
authors.forename: Tuyoshi
authors.initials: T
authors.lastname: Araki
authors.forename: Noriyoshi
authors.initials: N
authors.lastname: Ishikawa
authors.forename: Takeshi
authors.initials: T
authors.lastname: Taketani
authors.forename: Seiji
authors.initials: S
authors.lastname: Mishima
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shibata
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nagai
mesh_terms: D051997:ADP-ribosyl Cyclase 1; D000368:Aged; D018941:Antigens, CD19; D014408:Biomarkers, Tumor / Q000097:blood*; D019002:CD56 Antigen; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D017563:Lung Diseases, Interstitial; D008297:Male; D018396:Mucin-1 / Q000097:blood*; D009101:Multiple Myeloma / Q000175:diagnosis*
chemical_list: D018941:Antigens, CD19; D014408:Biomarkers, Tumor; D019002:CD56 Antigen; C060192:MUC1 protein, human; D018396:Mucin-1; D051997:ADP-ribosyl Cyclase 1