title: Vascular calcifications in chronic kidney disease--clinical management.
abstract: Chronic kidney disease (CKD) patients could present various types of calcifications causing different pathological conditions that would contribute to the renal disease progression and high risk of mortality. Extra-skeletal calcifications represent a common consequence of mineral bone disorders in CKD patients. Vascular calcifications represent a complex systemic manifestation caused by phospho-calcium homeostasis disorders, by imbalance among promoters and inhibitors of calcification and the presence of various arterial diseases and other risk factors. Consequently, vascular calcification can be considered an active pathological process that resembles osteogenesis. Therefore, before starting a suitable therapy for the prevention or delay of vascular calcifications, our recommendations are: to perform lateral abdominal radiography or CT-based techniques in CKD stages 3-5 patients for an early vascular calcification detection, to assess thoroughly patients presenting hyperphosphatemia, hyperparathyroidism, vitamin D deficiency and to understand clearly the pathophysiology of arterial calcification and calciphylaxis.
authors.affiliation: Department of Nephrology, Urology and Transplant Immunology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania. fizij@yahoo.com
authors.forename: I A
authors.initials: IA
authors.lastname: Checheriţă
authors.forename: Diana
authors.initials: D
authors.lastname: Smarandache
authors.forename: Cristiana
authors.initials: C
authors.lastname: David
authors.forename: Al
authors.initials: A
authors.lastname: Ciocâlteu
authors.forename: Daniela Adriana
authors.initials: DA
authors.lastname: Ion
authors.forename: I
authors.initials: I
authors.lastname: Lascăr
mesh_terms: D002309:Cardiology / Q000379:methods; D018450:Disease Progression; D006801:Humans; D006961:Hyperparathyroidism / Q000175:diagnosis; D054559:Hyperphosphatemia / Q000175:diagnosis; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000503:physiopathology*; D012307:Risk Factors; D014057:Tomography, X-Ray Computed / Q000379:methods; D061205:Vascular Calcification / Q000150:complications* / Q000503:physiopathology*; D014808:Vitamin D Deficiency