title: Prolonged disynaptic inhibition in the cortex mediated by slow, non-α7 nicotinic excitation of a specific subset of cortical interneurons.
abstract: Cholinergic activation of nicotinic receptors in the cortex plays a critical role in arousal, attention, and learning. Here we demonstrate that cholinergic axons from the basal forebrain of mice excite a specific subset of cortical interneurons via a remarkably slow, non-α7 nicotinic receptor-mediated conductance. In turn, these inhibitory cells generate a delayed and prolonged wave of disynaptic inhibition in neighboring cortical neurons, altering the spatiotemporal pattern of inhibition in cortical circuits.
authors.affiliation: Department of Comparative Medicine, Stanford University School of Medicine, Stanford, California 94305, College of Optical Science, University of Arizona, Tucson, Arizona 85721, USA.
authors.forename: Sergio
authors.initials: S
authors.lastname: Arroyo
authors.forename: Corbett
authors.initials: C
authors.lastname: Bennett
authors.forename: David
authors.initials: D
authors.lastname: Aziz
authors.forename: Solange P
authors.initials: SP
authors.lastname: Brown
authors.forename: Shaul
authors.initials: S
authors.lastname: Hestrin
mesh_terms: D000200:Action Potentials / Q000235:genetics / Q000502:physiology*; D000818:Animals; D001369:Axons / Q000502:physiology; D002540:Cerebral Cortex / Q000166:cytology / Q000502:physiology*; D059329:Cholinergic Neurons / Q000502:physiology; D005260:Female; D007395:Interneurons / Q000145:classification / Q000502:physiology*; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D009433:Neural Inhibition / Q000502:physiology*; D011930:Reaction Time / Q000235:genetics; D011978:Receptors, Nicotinic / Q000502:physiology*; D013569:Synapses / Q000235:genetics / Q000502:physiology*; D013997:Time Factors; D064569:alpha7 Nicotinic Acetylcholine Receptor
chemical_list: C579166:Chrna7 protein, mouse; D011978:Receptors, Nicotinic; D064569:alpha7 Nicotinic Acetylcholine Receptor