title: Base pair openings and temperature dependence of DNA flexibility.
abstract: The relationship of base pair openings to DNA flexibility is examined. Published experimental data on the temperature dependence of the persistence length by two different groups are well described in terms of an inhomogeneous Kratky-Porot model with soft and hard joints, corresponding to open and closed base pairs, and sequence-dependent statistical information about the state of each pair provided by a Peyrard-Bishop-Dauxois (PBD) model calculation with no freely adjustable parameters.
authors.affiliation: Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation, Athens, Greece.
authors.forename: Nikos
authors.initials: N
authors.lastname: Theodorakopoulos
authors.forename: Michel
authors.initials: M
authors.lastname: Peyrard
mesh_terms: D020029:Base Pairing; D003198:Computer Simulation; D004247:DNA / Q000737:chemistry*; D008962:Models, Theoretical; D013696:Temperature
chemical_list: D004247:DNA