title: Facile synthesis, characterization and pharmacological activities of 3,6-disubstituted 1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles and 5,6-dihydro-3,6-disubstituted-1,2,4-triazolo[3,4-b][1,3,4]thiadiazoles.
abstract: Two new series of compounds namely, 3,6-disubstituted-1,2,4-triazolo[3,4-b][1,3,4]thiadizoles (5a-j) and 5,6-dihydro-3,6-disubstituted-1,2,4-triazolo[3,4-b][1,3,4]thiadizoles (7a-j) were prepared. In continuation of a previously reported study, the first series (5a-j) were synthesized by the cyclocondensation of 4-amino-5-(2-bromo-5-methoxyphenyl)-2,4-dihydro-3H-1,2,4-triazole-3-thione (4) with various substituted aromatic carboxylic acids in phosphorus oxychloride and the second series (7a-j) by the reaction of (4) with various substituted aromatic aldehydes in the presence of p-Toluene sulfonic acid. Reaction of (4) with the aldehyde (9) afforded the Schiff's base (10) and not the cyclised product (11) on treatment with p-Toluene sulfonic acid. Synthesized compounds were structurally confirmed by spectral analysis and studied for their anti-inflammatory, analgesic, anti-oxidant and antimicrobial activities. Some of the tested compounds showed significant pharmacological activities.
authors.affiliation: Department of Studies in Chemistry, Mangalore University, Mangalagangothri, Karnataka 574 199, India.
authors.forename: N
authors.initials: N
authors.lastname: Chidananda
authors.forename: Boja
authors.initials: B
authors.lastname: Poojary
authors.forename: V
authors.initials: V
authors.lastname: Sumangala
authors.forename: N Suchetha
authors.initials: NS
authors.lastname: Kumari
authors.forename: Prashanth
authors.initials: P
authors.lastname: Shetty
authors.forename: T
authors.initials: T
authors.lastname: Arulmoli
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000737:chemistry; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D010851:Picrates / Q000737:chemistry; D051381:Rats; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D014230:Triazoles / Q000737:chemistry*
chemical_list: D000700:Analgesics; D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D000935:Antifungal Agents; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D010851:Picrates; D013830:Thiadiazoles; D014230:Triazoles; C004931:1,1-diphenyl-2-picrylhydrazyl