title: UBAP1: a new ESCRT member joins the cl_Ub.
abstract: The ESCRTs play multiple roles within the cell, including degradation of ubiquitinated membrane proteins by sorting them into multivesicular bodies (MVBs). Two recent studies provide structural and functional insights into how the newly identified ESCRT-I component UBAP1 dedicates ESCRT-I function for sorting ubiquitinated proteins at the MVB (Agromayor et al., 2012 [this issue of Structure]; Stefani et al., 2011).
authors.affiliation: Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA 52242, USA.
authors.forename: Natasha
authors.initials: N
authors.lastname: Pashkova
authors.forename: Robert C
authors.initials: RC
authors.lastname: Piper