title: Chemical constituents of Euphorbia tangutica.
abstract: Sixteen known compounds isolated from the whole plants of Euphorbia tangutica, including phorbol-13-actate (1) previously synthesised and obtained from a natural source for the first time, were evaluated in vitro against a panel of human cancer cell lines using the MTT method. Among them, ergosterol (6) exhibited significant cytotoxic activity against HL-60 cell line with an IC(50) value of 3.3 µM, and 3β,5α-dihydroxy-15β-cinnamoyloxy-14-oxolathyra-6 Z,12 E-diene (7) also displayed moderate activity.
authors.affiliation: Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810008, China.
authors.forename: Ben-Yin
authors.initials: BY
authors.lastname: Zhang
authors.forename: Huan
authors.initials: H
authors.lastname: Wang
authors.forename: Xiao-Dong
authors.initials: XD
authors.lastname: Luo
authors.forename: Zhi-Zhi
authors.initials: ZZ
authors.lastname: Du
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Wu
authors.forename: Jian-Wei
authors.initials: JW
authors.lastname: Shen
authors.forename: Xiao-feng
authors.initials: XF
authors.lastname: Zhang
mesh_terms: D000704:Analysis of Variance; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004797:Enzyme-Linked Immunosorbent Assay; D004875:Ergosterol / Q000302:isolation & purification / Q000633:toxicity; D028481:Euphorbia / Q000737:chemistry*; D018922:HL-60 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010703:Phorbol Esters / Q000302:isolation & purification / Q000633:toxicity; D010936:Plant Extracts / Q000302:isolation & purification* / Q000633:toxicity*; D013778:Tetrazolium Salts; D013844:Thiazoles
chemical_list: D010703:Phorbol Esters; D010936:Plant Extracts; D013778:Tetrazolium Salts; D013844:Thiazoles; C050164:phorbol 13-monoacetate; C022616:thiazolyl blue; D004875:Ergosterol