title: EN-RAGE (extracellular newly identified receptor for advanced glycation end-products binding protein) and mortality of long-term hemodialysis patients: A prospective observational cohort study.
abstract: OBJECTIVE
  EN-RAGE is extracellular newly identified receptor for advanced glycation end-products binding protein playing a role in inflammation. The aim was to test the relationship of EN-RAGE to prognosis of long-term hemodialysis patients (HD).
  
  
  METHODS
  This is a prospective observational cohort study in 261 HD patients followed up for five years. Laboratory parameters were measured at the beginning of the study.
  
  
  RESULTS
  EN-RAGE was slightly but unsignificantly increased in HD patients compared with healthy controls and correlated significantly with inflammatory markers. Univariate Cox analysis demonstrated EN-RAGE as a significant predictor for mortality due to infection (HR (95%CI): 1.305 (1.063-1.602), per standard deviation, p=0.01), but this significance disappeared in multivariate Cox analysis when CRP was included into the model.
  
  
  CONCLUSIONS
  Our study demonstrates EN-RAGE as an inflammatory biomarker. It is related to mortality of HD patients due to infection, but in our study, it did not provide additional information to CRP.
authors.affiliation: Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, U Nemocnice 2, 1280 Prague, Czech Republic. marta.kalousova@lf1.cuni.cz
authors.forename: Marta
authors.initials: M
authors.lastname: Kalousová
authors.forename: Aleš A
authors.initials: AA
authors.lastname: Kuběna
authors.forename: Hana
authors.initials: H
authors.lastname: Benáková
authors.forename: Sylvie
authors.initials: S
authors.lastname: Dusilová-Sulková
authors.forename: Vladimír
authors.initials: V
authors.lastname: Tesař
authors.forename: Tomáš
authors.initials: T
authors.lastname: Zima
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis*; D002318:Cardiovascular Diseases / Q000378:metabolism / Q000401:mortality*; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007239:Infections / Q000378:metabolism / Q000401:mortality; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D006435:Renal Dialysis / Q000401:mortality*; D009418:S100 Proteins / Q000097:blood*; D000067616:S100A12 Protein; D013997:Time Factors
chemical_list: D015415:Biomarkers; D009418:S100 Proteins; D000067616:S100A12 Protein; C090441:S100A12 protein, human; D002097:C-Reactive Protein