title: Scandium(III)-zeolites as new heterogeneous catalysts for imino-Diels-Alder reactions.
abstract: This study demonstrates the first zeolite-catalyzed synthesis of piperidine derivatives, including peptidomimetics and indoloquinolizidine alkaloids. The approach developed utilizes a highly effective one-pot reaction cascade, through imine formation and imino-Diels-Alder reactions, promoted by scandium-loaded zeolites as a heterogeneous catalyst. The methodology described benefits from very low catalyst loadings (≤5 mol % of Sc(III) ), commercially and readily available starting materials, and mild reaction conditions. Furthermore, the Sc(III) -zeolite catalyst can be readily reused more than 10 times without any loss in efficiency.
authors.affiliation: Institute of Chemistry, UMR 7177, Université de Strasbourg, 4 rue B. Pascal, 67000 Strasbourg, France.
authors.forename: Andrea
authors.initials: A
authors.lastname: Olmos
authors.forename: Benoit
authors.initials: B
authors.lastname: Louis
authors.forename: Patrick
authors.initials: P
authors.lastname: Pale
mesh_terms: D002384:Catalysis; D007097:Imines / Q000737:chemistry*; D015394:Molecular Structure; D010880:Piperidines / Q000138:chemical synthesis* / Q000737:chemistry*; D012538:Scandium / Q000737:chemistry*; D013237:Stereoisomerism; D017641:Zeolites / Q000737:chemistry*
chemical_list: D007097:Imines; D010880:Piperidines; D017641:Zeolites; D012538:Scandium