title: BRCA1 as a tumor suppressor linked to the regulation of epigenetic states: keeping oncomiRs under control.
abstract: BRCA1 is a tumor suppressor gene known to be implicated in the development of a subset of breast and ovarian cancers. The tumor suppressor properties of BRCA1 are generally thought to be linked to the gene's critical roles in the network of DNA damage response. In a recent report, BRCA1-mediated epigenetic repression at the promoter region of miRNA-155 was identified as a novel mechanism by which BRCA1 carries out its tumor suppressor functions.
authors.affiliation: Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), 08908 L'Hospitalet, Barcelona, Catalonia, Spain.
authors.forename: Olafur Andri
authors.initials: OA
authors.lastname: Stefansson
authors.forename: Manel
authors.initials: M
authors.lastname: Esteller
mesh_terms: D019313:BRCA1 Protein / Q000235:genetics* / Q000378:metabolism; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D063185:Epigenetic Repression; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D035683:MicroRNAs / Q000235:genetics; D009154:Mutation; D010051:Ovarian Neoplasms / Q000235:genetics*; D011401:Promoter Regions, Genetic
chemical_list: D019313:BRCA1 Protein; C492913:BRCA1 protein, human; C524942:MIRN155 microRNA, human; D035683:MicroRNAs