title: Nickel-catalyzed Negishi alkylations of styrenyl aziridines.
abstract: A nickel-catalyzed cross-coupling reaction between N-sulfonyl aziridines and organozinc reagents is reported. The catalytic system comprises an inexpensive and air-stable Ni(II) source and dimethyl fumarate as ligand. Regioselective synthesis of β-substituted amines is possible under mild and functional-group-tolerant conditions. The stereoselectivity of the reaction is consistent with a stereoconvergent mechanism wherein the sulfonamide directs C-C bond formation.
authors.affiliation: Department of Chemistry, Princeton University, Princeton, New Jersey 08544, USA.
authors.forename: Chung-Yang
authors.initials: CY
authors.lastname: Huang
authors.forename: Abigail G
authors.initials: AG
authors.lastname: Doyle