title: Carboline alkaloids from Psammosilene tunicoides and their cytotoxic activities.
abstract: Five new carboline alkaloids, tunicoidines A-E ( 1- 5), and two known carboline alkaloids, 1-acetyl-β-carboline-3-carboxylic acid ( 6) and 1-acetyl-3-carbomethoxyl- β-carboline ( 7), were isolated for the first time from the root of Psammosilene tunicoides. The structures of the new carboline alkaloids were established on the basis of 1D- and 2D-NMR, and HR-MS spectroscopic analyses. The seven compounds were evaluated for cytotoxicity against A549, HCT116, ZR-75-30, and HL-60 cell lines. However, only compound 7 had potent cytotoxic activity against the HCT116 cell line with an IC (50) value of 9.67 µg/mL, while the others showed no cytotoxic activities against the four tested cell lines.
authors.affiliation: Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai, P. R. China.
authors.forename: Junmian
authors.initials: J
authors.lastname: Tian
authors.forename: Yunheng
authors.initials: Y
authors.lastname: Shen
authors.forename: Huiliang
authors.initials: H
authors.lastname: Li
authors.forename: Runhui
authors.initials: R
authors.lastname: Liu
authors.forename: Lei
authors.initials: L
authors.lastname: Shan
authors.forename: Jinming
authors.initials: J
authors.lastname: Gao
authors.forename: Weidong
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002243:Carbolines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D029748:Caryophyllaceae / Q000737:chemistry*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification; D006801:Humans; D020128:Inhibitory Concentration 50; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D002243:Carbolines; D004365:Drugs, Chinese Herbal