title: Comparative analysis of hepatopulmonary shunt obtained from pretherapy 99mTc MAA scintigraphy and post-therapy 90Y Bremsstrahlung imaging in 90Y microsphere therapy.
abstract: BACKGROUND
  (99m)Tc macroaggregate albumin (MAA) scintigraphy is routinely used to estimate the hepatopulmonary shunt (HPS) of (90)Y microspheres because of their comparable average particle sizes (20-30 µm). However, the MAA particle size can vary from 10 to 90 µm. Therefore, HPS computed from (99m)Tc MAA scintigraphy may not accurately represent the HPS of (90)Y microspheres. In view of this, the present study was undertaken to investigate the accuracy of (99m)Tc MAA scintigraphy in estimating the HPS of (90)Y microspheres.
  
  
  METHODS
  Nineteen sessions of transarterial radioembolization using (90)Y therasphere were carried out in 17 patients for hepatic malignancies (both primary and secondary). For each session of therapy, a pretherapeutic (99m)Tc MAA scintigraphy and post-therapeutic (90)Y Bremsstrahlung scintigraphy were performed. The HPSs obtained from these images were compared.
  
  
  RESULTS
  The mean HPS fractions calculated from the pretherapeutic (99m)Tc MAA study and the post-therapeutic (90)Y Bremsstrahlung images were 4.77 ± 2.81 and 4.52 ± 2.5%, respectively. The coefficient of correlation (r) was 0.96.
  
  
  CONCLUSIONS
  (99m)Tc MAA scintigraphy accurately predicts the HPS of (90)Y microspheres.
authors.affiliation: Bio-Imaging Unit, Department of Radiodiagnosis, Tata Memorial Hospital, Mumbai, India.
authors.forename: Ashish Kumar A
authors.initials: AK
authors.lastname: Jha
authors.forename: Anand A
authors.initials: AA
authors.lastname: Zade
authors.forename: Venkatesh
authors.initials: V
authors.lastname: Rangarajan
authors.forename: Nilendu
authors.initials: N
authors.lastname: Purandare
authors.forename: Sneha A
authors.initials: SA
authors.lastname: Shah
authors.forename: Archi
authors.initials: A
authors.lastname: Agrawal
authors.forename: Suyash S
authors.initials: SS
authors.lastname: Kulkarni
authors.forename: Nitin
authors.initials: N
authors.lastname: Shetty
mesh_terms: D000328:Adult; D000368:Aged; D004621:Embolization, Therapeutic / Q000379:methods; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000532:radiotherapy; D008168:Lung / Q000000981:diagnostic imaging* / Q000528:radiation effects; D008863:Microspheres; D008875:Middle Aged; D010316:Particle Size; D011379:Prognosis; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D013668:Technetium Tc 99m Aggregated Albumin; D015021:Yttrium Radioisotopes / Q000627:therapeutic use
chemical_list: D019275:Radiopharmaceuticals; D013668:Technetium Tc 99m Aggregated Albumin; D015021:Yttrium Radioisotopes