title: A novel method to enhance the efficiency of drug transdermal iontophoresis delivery by using complexes of drug and ion-exchange fibers.
abstract: The main reason for generally low efficiency of the transdermal iontophoretic drug delivery is that the fraction of the total current contributed by the drug ions is very small. The objective of this study was to find a method to increase the fraction of the total current contributed by the drug ions so as to enhance the drug's iontophoretic delivery. Iontophoretic transport of diclofenac solution and diclofenac assisted by ion exchange materials, including ion-exchange resin, ion-exchange membrane and ion-exchange fiber, across the rat skin were investigated. Both in vitro and in vivo iontophoretic transport experiments showed the amount of diclofenac permeated across rat skin from the diclofenac-fibers was highest among those from the diclofenac simple solutions and ion exchange materials complexes. The results of this study suggested that there is an enhancement of drug across rat skin by ion-exchange fibers in ion-exchange fibers assisted iontophoresis. The present study has demonstrated the potential of a new approach using ion-exchange fibers to enhance transdermal iontophoretic transport of an ionizable drug.
authors.affiliation: School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China.
authors.forename: Che
authors.initials: C
authors.lastname: Xin
authors.forename: Wang
authors.initials: W
authors.lastname: Li-hong
authors.forename: Yuan
authors.initials: Y
authors.lastname: Yue
authors.forename: Gao
authors.initials: G
authors.lastname: Ya-nan
authors.forename: Wang
authors.initials: W
authors.lastname: Qi-fang
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.forename: Li
authors.initials: L
authors.lastname: San-ming
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D001692:Biological Transport; D004008:Diclofenac / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D007474:Ion Exchange; D007475:Ion Exchange Resins / Q000737:chemistry*; D007477:Ions / Q000737:chemistry; D007478:Iontophoresis / Q000379:methods*; D008297:Male; D010539:Permeability; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000378:metabolism*; D012869:Skin Absorption
chemical_list: D007475:Ion Exchange Resins; D007477:Ions; D004008:Diclofenac