title: Effect of delayed umbilical cord clamping on blood gas analysis.
abstract: OBJECTIVE
  To ascertain if there are differences in umbilical cord blood gas analysis between immediate and delayed cord clamping.
  
  
  METHODS
  In a prospective observational study on 60 vaginally delivered healthy term newborns, we sampled umbilical cord blood immediately after delivery and at the time umbilical cord pulsation spontaneously ceased.
  
  
  RESULTS
  There were significant decreases in pH, oxygen saturation (sO(2)), glycemia, oxygen content (ctO(2)), bicarbonate (HCO(3)(-)) and base excess (BE). Lactate and  [Formula: see text]  increased. Delayed cord clamping pH correlated with immediate cord clamping pH,  [Formula: see text] , ctHb, sO(2) and time (r(2)=0.77, p<0.000). Delayed cord clamping lactate was associated with immediate cord clamping lactate and time (r(2)=0.83, p<0.000). Delayed BE was associated with previous pH, lactate, glycemia, ctHb and time (r(2)=0.83, p<0.000).
  
  
  CONCLUSIONS
  Delayed cord clamping alters acid-base parameters and lactate values compared to immediate cord clamping. Those variations depend mainly on time, prior pH and lactate.
authors.affiliation: Obstetrics Department, University Hospital La Fe, Valencia, Spain.
authors.forename: Javier
authors.initials: J
authors.lastname: Valero
authors.forename: Domingo
authors.initials: D
authors.lastname: Desantes
authors.forename: Alfredo
authors.initials: A
authors.lastname: Perales-Puchalt
authors.forename: Juan
authors.initials: J
authors.lastname: Rubio
authors.forename: Vicente J
authors.initials: VJ
authors.lastname: Diago Almela
authors.forename: Alfredo
authors.initials: A
authors.lastname: Perales
mesh_terms: D001784:Blood Gas Analysis; D001786:Blood Glucose / Q000032:analysis; D003250:Constriction; D036861:Delivery, Obstetric / Q000379:methods*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D007231:Infant, Newborn; D019344:Lactic Acid / Q000032:analysis; D008297:Male; D010100:Oxygen / Q000032:analysis; D011247:Pregnancy; D013997:Time Factors; D014470:Umbilical Cord
chemical_list: D001786:Blood Glucose; D019344:Lactic Acid; D010100:Oxygen