title: Pick's disease.
abstract: Picks disease is a major clinicopathological disease having circumscribed atrophy in the frontotemporal lobe. Demented patients with frontotemporal atrophy are now clinically diagnosed as frontotemporal lobar degeneration (FTLD). Other underlying pathologies in patients with FTLD include FTLD with TDP-43-positive inclusions, corticobasal degeneration, progressive supranuclear palsy, basophilic inclusion body disease, neuronal intermediate filament inclusion disease and argyrophilic grain disease. In this chapter, recent findings regarding the distinct clinical and histopathological features of these pathological disease entities are presented including the discussion on the possibility of future antemortem diagnosis of patients with the disease.In this chapter, recent findings regarding the distinct clinical and histopathological features of these pathological disease entities are presented including the discussion on the possibility of future antemortem diagnosis of patients with the disease.
authors.affiliation: Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan.
authors.forename: Naoya
authors.initials: N
authors.lastname: Takeda
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kishimoto
authors.forename: Osamu
authors.initials: O
authors.lastname: Yokota
mesh_terms: D005625:Frontal Lobe / Q000378:metabolism / Q000473:pathology*; D057174:Frontotemporal Lobar Degeneration / Q000145:classification / Q000378:metabolism / Q000473:pathology; D006801:Humans; D020774:Pick Disease of the Brain / Q000175:diagnosis; D013702:Temporal Lobe / Q000378:metabolism / Q000473:pathology; D016875:tau Proteins / Q000378:metabolism
chemical_list: D016875:tau Proteins