title: Biomarkers of oxidative stress and risk of developing colorectal cancer: a cohort-nested case-control study in the European Prospective Investigation Into Cancer and Nutrition.
abstract: Oxidative stress has been shown to play an important role in carcinogenesis, but prospective evidence for an association between biomarkers of oxidative stress and colorectal cancer (CRC) risk is limited. The authors investigated the association between prediagnostic serum levels of oxidative stress indicators (i.e., reactive oxygen metabolites (ROM) and ferric reducing ability of plasma (FRAP)) and CRC risk. This was examined in a nested case-control study (1,064 CRC cases, 1,064 matched controls) in the European Prospective Investigation Into Cancer and Nutrition cohort (1992-2003). Incidence rate ratios and 95% confidence intervals were calculated using conditional logistic regression analyses. ROM were associated with overall CRC risk (highest tertile vs. lowest: adjusted incidence rate ratio (IRR(adj)) = 1.91, 95% confidence interval (CI): 1.47, 2.48), proximal (IRR(adj) = 1.89, 95% CI: 1.06, 3.36) and distal (IRR(adj) = 2.31, 95% CI: 1.37, 3.89) colon cancer, and rectal cancer (IRR(adj) = 1.69, 95% CI: 1.05, 2.72). When results were stratified by tertile of follow-up time, the association remained significant only in participants with less than 2.63 years of follow-up (IRR(adj) = 2.28, 95% CI: 1.78, 2.94; P-heterogeneity < 0.01). FRAP was not associated with CRC risk. In conclusion, prediagnostic serum ROM levels were associated with increased risk of CRC. However, this association was seen only in subjects with relatively short follow-up, suggesting that the association results from production of reactive oxygen species by preclinical tumors.
authors.affiliation: National Institute for Public Health and the Environment, Bilthoven, the Netherlands.
authors.forename: Anke M
authors.initials: AM
authors.lastname: Leufkens
authors.forename: Fränzel J B
authors.initials: FJ
authors.lastname: van Duijnhoven
authors.forename: Sjoukje H S
authors.initials: SH
authors.lastname: Woudt
authors.forename: Peter D
authors.initials: PD
authors.lastname: Siersema
authors.forename: Mazda
authors.initials: M
authors.lastname: Jenab
authors.forename: Eugene H J M
authors.initials: EH
authors.lastname: Jansen
authors.forename: Tobias
authors.initials: T
authors.lastname: Pischon
authors.forename: Anne
authors.initials: A
authors.lastname: Tjønneland
authors.forename: Anja
authors.initials: A
authors.lastname: Olsen
authors.forename: Kim
authors.initials: K
authors.lastname: Overvad
authors.forename: Marie Christine
authors.initials: MC
authors.lastname: Boutron-Ruault
authors.forename: Françoise
authors.initials: F
authors.lastname: Clavel-Chapelon
authors.forename: Sophie
authors.initials: S
authors.lastname: Morois
authors.forename: Domenico
authors.initials: D
authors.lastname: Palli
authors.forename: Valeria
authors.initials: V
authors.lastname: Pala
authors.forename: Rosario
authors.initials: R
authors.lastname: Tumino
authors.forename: Paolo
authors.initials: P
authors.lastname: Vineis
authors.forename: Salvatore
authors.initials: S
authors.lastname: Panico
authors.forename: Rudolf
authors.initials: R
authors.lastname: Kaaks
authors.forename: Annekatrin
authors.initials: A
authors.lastname: Lukanova
authors.forename: Heiner
authors.initials: H
authors.lastname: Boeing
authors.forename: Krasimira
authors.initials: K
authors.lastname: Aleksandrova
authors.forename: Antonia
authors.initials: A
authors.lastname: Trichopoulou
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Trichopoulos
authors.forename: Vardis
authors.initials: V
authors.lastname: Dilis
authors.forename: Petra H
authors.initials: PH
authors.lastname: Peeters
authors.forename: Guri
authors.initials: G
authors.lastname: Skeie
authors.forename: Carlos A
authors.initials: CA
authors.lastname: González
authors.forename: Marcial
authors.initials: M
authors.lastname: Argüelles
authors.forename: María-José
authors.initials: MJ
authors.lastname: Sánchez
authors.forename: Miren
authors.initials: M
authors.lastname: Dorronsoro
authors.forename: José María
authors.initials: JM
authors.lastname: Huerta
authors.forename: Eva
authors.initials: E
authors.lastname: Ardanaz
authors.forename: Göran
authors.initials: G
authors.lastname: Hallmans
authors.forename: Richard
authors.initials: R
authors.lastname: Palmqvist
authors.forename: Kay-Tee
authors.initials: KT
authors.lastname: Khaw
authors.forename: Nick
authors.initials: N
authors.lastname: Wareham
authors.forename: Naomi E
authors.initials: NE
authors.lastname: Allen
authors.forename: Francesca L
authors.initials: FL
authors.lastname: Crowe
authors.forename: Veronika
authors.initials: V
authors.lastname: Fedirko
authors.forename: Teresa
authors.initials: T
authors.lastname: Norat
authors.forename: Elio
authors.initials: E
authors.lastname: Riboli
authors.forename: H Bas
authors.initials: HB
authors.lastname: Bueno-de-Mesquita
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D015179:Colorectal Neoplasms / Q000453:epidemiology* / Q000209:etiology; D004032:Diet; D005060:Europe / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D017382:Reactive Oxygen Species / Q000097:blood; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D017382:Reactive Oxygen Species