title: Association of CTTN polymorphisms with the risk of colorectal cancer.
abstract: OBJECTIVE
  Various studies searching for biomarkers to predict tumor metastasis or prognosis in both esophageal squamous cell carcinoma (ESCC) and head and neck squamous cell carcinoma (HNSCC) are currently underway. However, few data have been reported on its association with colorectal cancer (CRC). Single nucleotide polymorphisms (SNPs) are the most common known form of human genetic variation and may contribute to an increased susceptibility to cancer including CRC. The present study aimed to investigate whether the polymorphisms in the CTTN gene are associated with susceptibility to CRC in the Korean population.
  
  
  METHODS
  A case-control study was performed to examine the relationship between the CTTN g.-9101C>T, g.-8748C>T, and g.72C>T polymorphisms and the risk of CRC. Polymerase chain reaction-restriction fragment length polymorphism analysis of g.-8748C>T, g.-9101C>T and Taqman analysis of g.72C>T were performed on blood samples from 218 patients with CRC and 533 control individuals. The g.-9101C>T, g.-8748C>T, and g.72C>T SNPs in CTTN and their haplotypes were analyzed.
  
  
  RESULTS
  The genotype and allele frequencies of g.-9101C>T, g.-8748C>T, and g.72C>T did not differ between the patient group and the control group. Further, the haplotype of CTTN g.-9101C>T, g.-8748C>T, and g.72C>T did not differ between patient group and the control group. However, the genotype and allele frequencies of CTTN g.-9101C>T were significantly increased in the lymph node positive CRC group compared to the control group.
  
  
  CONCLUSIONS
  The CTTN g.-9101C>T polymorphism may influence lymph node positive CRC.
authors.affiliation: Department of Surgery, Digestive Disease Research Institute and Institute of Medical Science, Wonkwang University College of Medicine, Iksan, Korea.
authors.forename: Seok Youn
authors.initials: SY
authors.lastname: Lee
authors.forename: Dong Baek
authors.initials: DB
authors.lastname: Kang
authors.forename: Won Cheol
authors.initials: WC
authors.lastname: Park
authors.forename: Jeong Kyun
authors.initials: JK
authors.lastname: Lee
authors.forename: Soo Cheon
authors.initials: SC
authors.lastname: Chae