title: The FCGR2B rs10917661 polymorphism may confer susceptibility to ankylosing spondylitis in Han Chinese: a case-control study.
abstract: OBJECTIVE
  Single-nucleotide polymorphisms (SNPs) in the Fc gamma receptor IIB (FCGR2B) gene have recently been found to be associated with several human autoimmune diseases. We undertook the current study to investigate the influence of these polymorphisms on the risk of ankylosing spondylitis (AS).
  
  
  METHODS
  A total of 306 patients with AS from Anhui, China, fulfilling the modified New York Criteria, and 300 matched healthy controls were analysed. All subjects were genotyped for two SNPs (rs1050501, rs10917661) in the FCGR2B gene, and the SNaPshot Assay was used for genotyping.
  
  
  RESULTS
  SNP rs10917661 was significantly associated with AS [C vs. T: odds ratio (OR) 1.723, 95% confidence interval (CI) 1.086-2.733, p = 0.020; genotype: p = 0.026] whereas no association was found for rs1050501. Furthermore, no haplotype was found to be associated with AS.
  
  
  CONCLUSIONS
  These findings indicated that rs10917661 may be a novel SNP involved in AS genetic predisposition in the Han Chinese population.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Anhui, China.
authors.forename: Z-H
authors.initials: ZH
authors.lastname: Duan
authors.forename: F-M
authors.initials: FM
authors.lastname: Pan
authors.forename: Z
authors.initials: Z
authors.lastname: Zeng
authors.forename: T-C
authors.initials: TC
authors.lastname: Zhang
authors.forename: S
authors.initials: S
authors.lastname: Wang
authors.forename: G-X
authors.initials: GX
authors.lastname: Li
authors.forename: Y
authors.initials: Y
authors.lastname: Mei
authors.forename: J
authors.initials: J
authors.lastname: Gao
authors.forename: R
authors.initials: R
authors.lastname: Ge
authors.forename: D-Q
authors.initials: DQ
authors.lastname: Ye
authors.forename: Y-F
authors.initials: YF
authors.lastname: Zou
authors.forename: S-Q
authors.initials: SQ
authors.lastname: Xu
authors.forename: J-H
authors.initials: JH
authors.lastname: Xu
authors.forename: L
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China / Q000208:ethnology; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017452:Receptors, IgG / Q000235:genetics*; D013167:Spondylitis, Ankylosing / Q000208:ethnology / Q000235:genetics*; D055815:Young Adult
chemical_list: C499173:FCGR2B protein, human; D017452:Receptors, IgG