title: Strategies for tissue and organ decellularization.
abstract: Decellularized tissues have been successfully used in a variety of tissue engineering/regenerative medicine applications, and more recently decellularized organs have been utilized in the first stages of organ engineering. The protocols used to decellularize simple tissues versus intact organs differ greatly. Herein, the most commonly used decellularization methods for both surgical mesh materials and whole organs are described, with consideration given to how these different processes affect the extracellular matrix and the host response to the scaffold.
authors.affiliation: Cardiothoracic Surgery, and Bioengineering, McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15224, USA. gilberttw@upmc.edu
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Gilbert
mesh_terms: D000818:Animals; D005109:Extracellular Matrix / Q000502:physiology; D006801:Humans; D012038:Regeneration; D044968:Regenerative Medicine; D013526:Surgical Mesh; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds