title: Adenovirus-induced interstitial nephritis following umbilical cord blood transplant for chronic lymphocytic leukemia.
abstract: We present a case of a 27-year-old man who received an unrelated donor umbilical cord blood transplant for chronic lymphocytic leukemia. His postsurgery course was complicated by acute kidney injury, hemorrhagic cystitis, and pancytopenia. Transjugular kidney biopsy showed interstitial nephritis. Viral inclusions were present in tubular epithelial cells, and in situ hybridization studies confirmed the presence of adenovirus. Kidney function improved after a short course of cidofovir. Adenovirus-induced interstitial nephritis should be considered in the differential diagnosis in all cases of interstitial nephritis occurring in immunocompromised patients.
authors.affiliation: Division of Nephrology and Hypertension, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: Mira
authors.initials: M
authors.lastname: Keddis
authors.forename: Nelson
authors.initials: N
authors.lastname: Leung
authors.forename: Sandra
authors.initials: S
authors.lastname: Herrmann
authors.forename: Ziad
authors.initials: Z
authors.lastname: El-Zoghby
authors.forename: Sanjeev
authors.initials: S
authors.lastname: Sethi
mesh_terms: D058186:Acute Kidney Injury / Q000628:therapy / Q000821:virology*; D000257:Adenoviridae Infections / Q000175:diagnosis* / Q000188:drug therapy / Q000821:virology; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D000077404:Cidofovir; D036101:Cord Blood Stem Cell Transplantation / Q000009:adverse effects* / Q000379:methods; D003596:Cytosine / Q000031:analogs & derivatives / Q000627:therapeutic use; D005312:Fetal Blood; D005500:Follow-Up Studies; D006801:Humans; D016867:Immunocompromised Host / Q000276:immunology; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications / Q000276:immunology / Q000628:therapy*; D008297:Male; D009395:Nephritis, Interstitial / Q000628:therapy / Q000821:virology*; D063065:Organophosphonates / Q000627:therapeutic use; D018570:Risk Assessment; D012720:Severity of Illness Index; D016896:Treatment Outcome; D061349:Unrelated Donors; D014766:Viremia / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology
chemical_list: D063065:Organophosphonates; D003596:Cytosine; D000077404:Cidofovir