title: Regulatory approval of plant sterols in Canada: implications for health care and clinical practice.
abstract: Health Canada's recent approval of plant sterols as food ingredients to decrease low-density lipoprotein cholesterol (LDL-C) is believed to be a significant step toward improving Canadians' cardiovascular health and reducing the economic burden of heart disease. When dyslipidemic patients consume plant sterols at a recommended daily dose of 2 g, they can reduce LDL-C by 10% to 15%, with no deleterious effects on high-density lipoprotein cholesterol. A 10% LDL-C reduction in response to plant sterol consumption is projected to reduce heart disease risk by 25%. Because they are available without a prescription, plant sterols are an option for dietitians who wish to provide cholesterol-lowering guidance beyond traditional dietary advice (i.e., lowering saturated fat intake and restricting dietary cholesterol). In addition, plant sterols can be used in combination with a statin or when statin use is contraindicated, and they have recently emerged as a potentially valuable triglyceride-lowering option. However, the projected improvement in public health and health care savings will be realized only if impediments to daily use are removed. One such impediment is the higher cost of fortified food products, such as yogurt and margarine. If the cost of plant sterol food products is to decline, cost-effective sources must be investigated and a larger range of foods containing plant sterols must be made available.
authors.affiliation: Department of Exercise and Nutrition Sciences, University at Buffalo, Buffalo, NY, USA.
authors.forename: Todd C
authors.initials: TC
authors.lastname: Rideout
authors.forename: Christopher P F
authors.initials: CP
authors.lastname: Marinangeli
authors.forename: Atif B
authors.initials: AB
authors.lastname: Awad
mesh_terms: D000924:Anticholesteremic Agents / Q000009:adverse effects / Q000592:standards / Q000627:therapeutic use*; D002170:Canada; D003257:Consumer Product Safety; D019587:Dietary Supplements / Q000009:adverse effects / Q000592:standards; D004046:Dietetics; D055317:Evidence-Based Practice; D005527:Food, Fortified / Q000009:adverse effects / Q000032:analysis / Q000592:standards; D006293:Health Promotion; D006801:Humans; D007881:Legislation, Food; D009313:National Health Programs; D010840:Phytosterols / Q000009:adverse effects / Q000592:standards / Q000627:therapeutic use*
chemical_list: D000924:Anticholesteremic Agents; D010840:Phytosterols