title: Fragrance material review on methyl hexyl oxo cyclopentanone carboxylate.
abstract: A toxicologic and dermatologic review of methyl hexyl oxo cyclopentanone carboxylate when used as a fragrance ingredient is presented. Methyl hexyl oxo cyclopentanone carboxylate is a member of the fragrance structural group ketones cyclopentanones and cyclopentenones. The common characteristic structural element of the group members is a cyclopentanone or cyclopentenone ring with a straight or branched chain alkane or alkene substituent. This review contains a detailed summary of all available toxicology and dermatology papers that are related to this individual fragrance ingredient and is not intended as a stand-alone document. Available data for methyl hexyl oxo cyclopentanone carboxylate were evaluated then summarized and includes physical properties, acute toxicity, skin irritation, skin sensitization, and genotoxicity data. A safety assessment of the entire ketones cyclopentanones and cyclopentenones will be published simultaneously with this document; please refer to Belsito et al. (this issue) for an overall assessment of the safe use of this material and all ketones cyclopentanones and cyclopentenones in fragrances.
authors.affiliation: Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ 07677, USA. jscognamiglio@rifm.org
authors.forename: J
authors.initials: J
authors.lastname: Scognamiglio
authors.forename: L
authors.initials: L
authors.lastname: Jones
authors.forename: C S
authors.initials: CS
authors.lastname: Letizia
authors.forename: A M
authors.initials: AM
authors.lastname: Api
mesh_terms: D000818:Animals; D002264:Carboxylic Acids / Q000493:pharmacokinetics / Q000633:toxicity*; D003517:Cyclopentanes / Q000493:pharmacokinetics / Q000633:toxicity*; D006801:Humans; D010476:Perfume; D011817:Rabbits; D012867:Skin / Q000187:drug effects*; D018675:Toxicity Tests
chemical_list: D002264:Carboxylic Acids; D003517:Cyclopentanes; D010476:Perfume