title: Venting-while-heating microwave-assisted synthesis of 3-arylthioindoles.
abstract: We report the first example of venting-while-heating microwave-assisted synthesis of a small library of 3-arylthioindoles. Compounds were prepared in excellent isolated yields (90-98%) within 4 min in a closed vessel by treating indoles with disulfides in the presence of sodium hydride in anhydrous N,N-dimethylformamide. The method was not affected by electron-donating and -withdrawing substituents both on 3-arylthio moiety and at 2- and 5-positions of the indole nucleus.
authors.forename: Giuseppe
authors.initials: G
authors.lastname: La Regina
authors.forename: Valerio
authors.initials: V
authors.lastname: Gatti
authors.forename: Valeria
authors.initials: V
authors.lastname: Famiglini
authors.forename: Francesco
authors.initials: F
authors.lastname: Piscitelli
authors.forename: Romano
authors.initials: R
authors.lastname: Silvestri
mesh_terms: D020650:Combinatorial Chemistry Techniques; D006358:Hot Temperature; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D008872:Microwaves; D015394:Molecular Structure; D054852:Small Molecule Libraries / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D007211:Indoles; D054852:Small Molecule Libraries; D013438:Sulfhydryl Compounds