title: Cognitive outcome after stereotactic amygdalohippocampectomy.
abstract: OBJECTIVE
  We sought to determine the neuropsychological outcome after stereotactic radiofrequency amygdalohippocampectomy performed for intractable mesial temporal lobe epilepsy.
  
  
  METHODS
  The article describes the cases of 31 patients who were evaluated using the Wechsler Adult Intelligence Scale-Revised and the Wechsler Memory Scale-Revised prior to, and one year after, surgery.
  
  
  RESULTS
  Patients showed increases in their mean Full Scale, Verbal and Performance IQ scores of 4, 3 and 4 IQ points respectively (p<.05). 5 (17.2%), 4 (13.8%) and 4 (13.3%) patients improved in their Full-scale, Verbal and Performance IQ respectively. No significant changes were found in memory performance - with a mean increase of 1, 3 and 0 MQ points in Global, Verbal and Visual memory respectively (p<.05). Global memory improved in 3 (10.3%) patients, verbal memory in 1 (3.4%) and 1 patient (3.3%) showed deterioration in visual memory.
  
  
  CONCLUSIONS
  Our results provide evidence for unchanged memory in patients with MTLE after the procedure. No verbal memory deterioration was detected in any of our patients, while improvements were found in intellectual performance. The results suggest that stereotactic radiofrequency amygdalahippocampectomy could be superior to open surgery in terms of its neurocognitive outcomes. A larger randomised trial of these approaches is justified.
authors.affiliation: Department of Neurology, Na Homolce Hospital, Prague, Czech Republic. zdenek.vojtech@homolka.cz
authors.forename: Zdeněk
authors.initials: Z
authors.lastname: Vojtěch
authors.forename: Lenka
authors.initials: L
authors.lastname: Krámská
authors.forename: Hana
authors.initials: H
authors.lastname: Malíková
authors.forename: Kateřina
authors.initials: K
authors.lastname: Seltenreichová
authors.forename: Tomáš
authors.initials: T
authors.lastname: Procházka
authors.forename: Miroslav
authors.initials: M
authors.lastname: Kalina
authors.forename: Roman
authors.initials: R
authors.lastname: Liščák
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000679:Amygdala / Q000473:pathology / Q000601:surgery*; D003072:Cognition Disorders / Q000601:surgery*; D004833:Epilepsy, Temporal Lobe / Q000601:surgery*; D005260:Female; D006624:Hippocampus / Q000473:pathology / Q000601:surgery*; D006801:Humans; D007361:Intelligence Tests; D008297:Male; D008568:Memory / Q000502:physiology; D008875:Middle Aged; D009483:Neuropsychological Tests; D019635:Neurosurgical Procedures / Q000379:methods*; D016896:Treatment Outcome; D055815:Young Adult