title: Herbicidal activity of curvuiinic acid isolated from Nimbya alternantherae.
abstract: A phytotoxic compound, identified as 2-(2-acetyl-3,5-dihydroxyphenyl) acetic acid (curvulinic acid), was isolated from liquid cultures of the phytopathogenic fungus Nimbya alternantherae. The activity of curvulinic acid on seed germination and seedling growth of Capsella bursa-pastoris was evaluated. Percentage seed germination of C. bursa-pastoris was decreased with increasing concentrations of curvulinic acid. The compound had stronger inhibitory effects on root length than shoot length. At a concentration of 600 microg x mL(-1), curvulinic acid caused 73.5% and 66.7% growth inhibition on roots and shoots with IC50 values of 204.7 and 281.1 microg x mL(-1), respectively. The finding of curvulinic acid in N. alternantherae and its herbicidal activity are reported here for the first time.
authors.affiliation: College of Plant Protection, Jiangsu Key Laboratory of Pesticide Science, Nanjing Agricultural University, Nanjing 210095, PR China.
authors.forename: Jun
authors.initials: J
authors.lastname: Li
authors.forename: Yonghao
authors.initials: Y
authors.lastname: Yea
authors.forename: Xiaoyang
authors.initials: X
authors.lastname: Wang
authors.forename: Liyao
authors.initials: L
authors.lastname: Dong
mesh_terms: D029687:Capsella / Q000187:drug effects; D005658:Fungi / Q000378:metabolism*; D006540:Herbicides / Q000494:pharmacology*; D010648:Phenylacetates / Q000494:pharmacology*
chemical_list: D006540:Herbicides; D010648:Phenylacetates; C515896:methyl 2-acetyl-3,5-dihydroxyphenylacetate