title: Early administration of low-dose aspirin for the prevention of preterm and term preeclampsia: a systematic review and meta-analysis.
abstract: OBJECTIVE
  To compare the effect of early administration of aspirin on the risk of preterm and term preeclampsia.
  
  
  METHODS
  A systematic review and meta-analysis of randomized controlled trials were performed. Women who were randomized to low-dose aspirin or placebo/no treatment at or before 16 weeks of gestation were included. The outcomes of interest were preterm preeclampsia (delivery <37 weeks) and term preeclampsia. Pooled relative risks (RR) with their 95% confidence intervals (CI) were computed.
  
  
  RESULTS
  The search identified 7,941 citations but only five trials on a combined total of 556 women fulfilled the inclusion criteria. When compared to controls, aspirin initiated ≤16 weeks of gestation was associated with a major reduction of the risk of preterm preeclampsia (RR 0.11, 95% CI 0.04-0.33) but had no significant effect on term preeclampsia (RR 0.98, 95% CI 0.42-2.33).
  
  
  CONCLUSIONS
  Low-dose aspirin administrated at or before 16 weeks of gestation reduces the risk of preterm but not term preeclampsia.
authors.affiliation: Department of Social and Preventive Medicine, Université Laval, Quebec City, Que., Canada.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Roberge
authors.forename: Pia
authors.initials: P
authors.lastname: Villa
authors.forename: Kypros
authors.initials: K
authors.lastname: Nicolaides
authors.forename: Yves
authors.initials: Y
authors.lastname: Giguère
authors.forename: Merja
authors.initials: M
authors.lastname: Vainio
authors.forename: Abdelouahab
authors.initials: A
authors.lastname: Bakthi
authors.forename: Alaa
authors.initials: A
authors.lastname: Ebrashy
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Bujold
mesh_terms: D001241:Aspirin / Q000008:administration & dosage*; D016009:Chi-Square Distribution; D004334:Drug Administration Schedule; D019317:Evidence-Based Medicine; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D016017:Odds Ratio; D010929:Placentation / Q000187:drug effects; D011225:Pre-Eclampsia / Q000503:physiopathology / Q000517:prevention & control*; D011247:Pregnancy; D016032:Randomized Controlled Trials as Topic; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D001241:Aspirin