title: Gold nanoparticles supported on nanoparticulate ceria as a powerful agent against intracellular oxidative stress.
abstract: Ceria-supported gold nanoparticles are prepared exhibiting peroxidase activity and acting as radical traps. Au/CeO(2)  shows a remarkable biocompatibility as demonstrated by measuring cellular viability, proliferation, and lack of apoptosis for two human cell lines (Hep3B and HeLa). The antioxidant activity of Au/CeO(2)  against reactive oxygen species (ROS) is demonstrated by studying the cellular behavior of Hep3B and HeLa in a model of cellular oxidative stress. It is determined that Au/CeO(2)  exhibits higher antioxidant activity than glutathione, the main cytosolic antioxidant compound, and its CeO(2)  carrier. Overall the result presented here shows the potential of implementing well-established nanoparticulated gold catalysts with remarkable biocompatibility in cellular biology.
authors.affiliation: Institut d'Alta Tecnologia-PRBB/CRC-Centre d'Imatge Molecular, Dr. Aiguader 88, 08003 Barcelona, Spain.
authors.forename: Cristina
authors.initials: C
authors.lastname: Menchón
authors.forename: Roberto
authors.initials: R
authors.lastname: Martín
authors.forename: Nadezda
authors.initials: N
authors.lastname: Apostolova
authors.forename: Victor M
authors.initials: VM
authors.lastname: Victor
authors.forename: Mercedes
authors.initials: M
authors.lastname: Alvaro
authors.forename: José Raúl
authors.initials: JR
authors.lastname: Herance
authors.forename: Hermenegildo
authors.initials: H
authors.lastname: García
mesh_terms: D000975:Antioxidants / Q000737:chemistry; D017209:Apoptosis; D001672:Biocompatible Materials / Q000737:chemistry; D002384:Catalysis; D002460:Cell Line; D049109:Cell Proliferation; D002470:Cell Survival; D006046:Gold / Q000737:chemistry*; D006367:HeLa Cells / Q000187:drug effects*; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D053758:Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D018384:Oxidative Stress; D010544:Peroxidases / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D017382:Reactive Oxygen Species / Q000378:metabolism; D013997:Time Factors
chemical_list: D000975:Antioxidants; D001672:Biocompatible Materials; D011108:Polymers; D017382:Reactive Oxygen Species; D006046:Gold; D010544:Peroxidases