title: Case study: technology initiative led to advanced lead optimization screening processes at Bristol-Myers Squibb, 2004-2009.
abstract: In this paper, we review the key solutions that enabled evolution of the lead optimization screening support process at Bristol-Myers Squibb (BMS) between 2004 and 2009. During this time, technology infrastructure investment and scientific expertise integration laid the foundations to build and tailor lead optimization screening support models across all therapeutic groups at BMS. Together, harnessing advanced screening technology platforms and expanding panel screening strategy led to a paradigm shift at BMS in supporting lead optimization screening capability. Parallel SAR and structure liability relationship (SLR) screening approaches were first and broadly introduced to empower more-rapid and -informed decisions about chemical synthesis strategy and to broaden options for identifying high-quality drug candidates during lead optimization.
authors.affiliation: Bristol-Myers Squibb, Research, PO Box 4000, Princeton, NJ 08543, USA. litao.zhang@bms.com
authors.forename: Litao
authors.initials: L
authors.lastname: Zhang
authors.forename: Mary Ellen
authors.initials: ME
authors.lastname: Cvijic
authors.forename: Jonathan
authors.initials: J
authors.lastname: Lippy
authors.forename: James
authors.initials: J
authors.lastname: Myslik
authors.forename: Stephen L
authors.initials: SL
authors.lastname: Brenner
authors.forename: Alastair
authors.initials: A
authors.lastname: Binnie
authors.forename: John G
authors.initials: JG
authors.lastname: Houston
mesh_terms: D000818:Animals; D055808:Drug Discovery / Q000191:economics / Q000379:methods*; D004345:Drug Industry / Q000191:economics / Q000379:methods / Q000458:organization & administration*; D064420:Drug-Related Side Effects and Adverse Reactions; D017598:Efficiency, Organizational; D057166:High-Throughput Screening Assays; D006801:Humans; D007449:Investments; D004364:Pharmaceutical Preparations / Q000737:chemistry; D013329:Structure-Activity Relationship; D013678:Technology, Pharmaceutical / Q000191:economics / Q000379:methods* / Q000458:organization & administration*
chemical_list: D004364:Pharmaceutical Preparations