title: Pregnancy outcome in women with endometriomas achieving pregnancy through IVF.
abstract: BACKGROUND
  There is a growing consensus that ovarian endometriomas should not be systematically removed in women selected for IVF. However, some recent evidence suggested that the presence of these cysts may negatively affect the course of pregnancy.
  
  
  METHODS
  We set up a multicenter retrospective cohort study, including two infertility units. We analyzed data from patients achieving singleton clinical pregnancies through IVF comparing the pregnancy outcome between 78 pregnant women with endometriomas at the time of IVF and 156 patients who achieved pregnancy through IVF without endometriomas.
  
  
  RESULTS
  The number of live births in women with and without endometriomas were 61 (78%) and 130 (83%), respectively (P = 0.39). The adjusted odds ratio (OR) of live birth in affected cases was 0.79 [95% confidence interval (CI): 0.38-1.68]. No differences were observed in late pregnancy and neonatal outcomes between the two groups. In particular, the rate of preterm birth and small-for-gestational age (SGA) was similar. The adjusted ORs were 0.47 (95% CI: 0.14-1.54) and 0.56 (95% CI: 0.12-2.56), respectively.
  
  
  CONCLUSIONS
  Women with endometriomas achieving pregnancy through IVF do not seem to be exposed to a significant increased risk of obstetrical complications.
authors.affiliation: Department of Obstetrics and Gynecology, Fondazione Cà Granda, Ospedale Maggiore Policlinico, Milan, Italy. laurabenaglia@hotmail.it
authors.forename: Laura
authors.initials: L
authors.lastname: Benaglia
authors.forename: Alfonso
authors.initials: A
authors.lastname: Bermejo
authors.forename: Edgardo
authors.initials: E
authors.lastname: Somigliana
authors.forename: Claudia
authors.initials: C
authors.lastname: Scarduelli
authors.forename: Guido
authors.initials: G
authors.lastname: Ragni
authors.forename: Luigi
authors.initials: L
authors.lastname: Fedele
authors.forename: Juan A
authors.initials: JA
authors.lastname: Garcia-Velasco
mesh_terms: D000328:Adult; D015331:Cohort Studies; D004715:Endometriosis / Q000150:complications*; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D007247:Infertility, Female / Q000209:etiology / Q000628:therapy*; D050498:Live Birth; D016017:Odds Ratio; D010049:Ovarian Diseases / Q000150:complications; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D047928:Premature Birth / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors