title: Effects of turmeric extract on the pharmacokinetics of nifedipine after a single oral administration in healthy volunteers.
abstract: The effects of turmeric extracts on the pharmacokinetics of nifedipine were examined in 10 healthy volunteers. An open-label and randomized crossover study was performed at 2-week intervals. In the control experiment, after a 10 h overnight fast, 10 mg of nifedipine (Adalat® capsule) was administered orally and blood was collected at 0, 0.5, 1, 2, 3, 4, 5, 6, and 8 h. In the combination experiment, the volunteers were orally administered 10 mg of nifedipine together with six tablets containing concentrated turmeric extract (480 mg of curcuminoid per six tablets), which is the general daily dose, and blood was sampled as above. The time profile of the plasma concentration of nifedipine in the control was comparable to that in combination with turmeric extract, as were the pharmacokinetic parameters: that is, the mean ratio of turmeric extract/control group (90% confidence interval: CI); C(max), 0.98 (0.95, 1.01) and AUC(0 - ∞) 1.00 (0.98, 1.02). In addition, the volunteers all completed the study without any serious adverse events. Consumption of the turmeric extract did not affect the pharmacokinetics of nifedipine after a single oral administration.
authors.affiliation: Department of Hospital Pharmacy, Faculty of Pharmaceutical Sciences, Kyoto Pharmaceutical University, 5-Nakauchi-cho, Misasagi, Yamashina-ku, Kyoto, 607-8414, Japan.
authors.forename: Mika
authors.initials: M
authors.lastname: Ikehata
authors.forename: Noriaki
authors.initials: N
authors.lastname: Ohnishi
authors.forename: Suguru
authors.initials: S
authors.lastname: Egami
authors.forename: Hisato
authors.initials: H
authors.lastname: Kishi
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Shin
authors.forename: Kohji
authors.initials: K
authors.lastname: Takara
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Tsuchishita
authors.forename: Naoko
authors.initials: N
authors.lastname: Tokuda
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hori
authors.forename: Yuko
authors.initials: Y
authors.lastname: Yatani
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Fujimura
authors.forename: Masaaki
authors.initials: M
authors.lastname: Kusumoto
authors.forename: Ryozo
authors.initials: R
authors.lastname: Tatami
authors.forename: Mutsunobu
authors.initials: M
authors.lastname: Yoshioka
authors.forename: Kazuo
authors.initials: K
authors.lastname: Kuroda
authors.forename: Sayuri
authors.initials: S
authors.lastname: Yamada
authors.forename: Teruyoshi
authors.initials: T
authors.lastname: Yokoyama
mesh_terms: D000284:Administration, Oral; D000328:Adult; D019540:Area Under Curve; D018592:Cross-Over Studies; D030024:Curcuma / Q000737:chemistry*; D005260:Female; D041743:Herb-Drug Interactions; D006801:Humans; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000097:blood / Q000493:pharmacokinetics*; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D012016:Reference Values; D055815:Young Adult
chemical_list: D010936:Plant Extracts; C012596:turmeric extract; D009543:Nifedipine