title: Chemerin analog regulates energy metabolism in sheep.
abstract: Accumulating data suggest a relationship between chemerin and energy metabolism. Our group previously described gene cloning, expression analysis and the regulatory mechanism of chemerin and its own receptor in mice and cattle. The objective of the present study was to investigate the physiological effect of chemerin on endocrine changes and energy metabolism in sheep using a biologically stable chemerin analog. The chemerin analog was intravenously administrated (100 or 500 µg/head) to sheep, and plasma insulin and metabolites (glucose, nonesterified fatty acids (NEFA), triglyceride, total cholesterol and high-density lipoprotein (HDL) cholesterol) were analyzed. The chemerin analog dramatically increased the insulin levels, and glucose levels were decreased. NEFA levels were slightly decreased at 20 min but then increased gradually from 60 to 180 min after analog administration. In addition, injection of the chemerin analog immediately increased triglyceride and total cholesterol but not HDL levels. These results suggested that chemerin analog regulated insulin secretion related to glucose metabolism and the release of triglycerides in sheep in vivo. This study provides new information about endocrine and metabolic changes in response to chemerin in sheep.
authors.affiliation: Laboratory of Animal Physiology, Graduate School of Agricultural Science, Tohoku University, Aoba, Sendai, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Sang-Houn
authors.initials: SH
authors.lastname: Song
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Sato
authors.forename: Kyoung-Ha
authors.initials: KH
authors.lastname: So
authors.forename: Astrid
authors.initials: A
authors.lastname: Ardiyanti
authors.forename: Shun
authors.initials: S
authors.lastname: Kitayama
authors.forename: Yeon-Hee
authors.initials: YH
authors.lastname: Hong
authors.forename: Sung-Dae
authors.initials: SD
authors.lastname: Lee
authors.forename: Ki-Choon
authors.initials: KC
authors.lastname: Choi
authors.forename: Akihiko
authors.initials: A
authors.lastname: Hagino
authors.forename: Kazuo
authors.initials: K
authors.lastname: Katoh
authors.forename: Sang-gun
authors.initials: SG
authors.lastname: Roh
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D018925:Chemokines / Q000502:physiology*; D002784:Cholesterol / Q000097:blood; D004734:Energy Metabolism / Q000502:physiology*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D008075:Lipoproteins, HDL / Q000097:blood; D012756:Sheep / Q000378:metabolism*; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D018925:Chemokines; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D008075:Lipoproteins, HDL; D014280:Triglycerides; D002784:Cholesterol