title: Isoflavones inhibit the clonogenicity of human colon cancer cells.
abstract: Isoflavones are a class of polyphenols that contain various substituents such as hydroxy, methoxy, and glycosyl groups. Methoxy groups are known to increase cell permeability and stability, but small structural changes can result in large differences in biological activity. In this study, the anticancer activities of several methoxy isoflavones were tested using a clonogenic survival assay. The relationship between structural properties of methoxy isoflavones and their anticancer activities on HCT116 colon cancer cell lines were studied quantitatively using comparative molecular field analysis and comparative molecular similarity indices analysis. The purpose of this study was to identify structural changes in isoflavones that increase the inhibitory effect on HCT116 colon cancer cell clonogenicity.
authors.affiliation: Division of Bioscience and Biotechnology, BMIC, Konkuk University, Seoul, Republic of Korea.
authors.forename: Jiye
authors.initials: J
authors.lastname: Hyun
authors.forename: Soon Young
authors.initials: SY
authors.lastname: Shin
authors.forename: Kyoung Min
authors.initials: KM
authors.lastname: So
authors.forename: Young Han
authors.initials: YH
authors.lastname: Lee
authors.forename: Yoongho
authors.initials: Y
authors.lastname: Lim
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D001681:Biological Assay; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002999:Clone Cells / Q000187:drug effects; D003110:Colonic Neoplasms / Q000188:drug therapy / Q000473:pathology*; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology; D045325:HCT116 Cells; D006801:Humans; D007529:Isoflavones / Q000737:chemistry / Q000494:pharmacology*; D008958:Models, Molecular; D015394:Molecular Structure
chemical_list: D000970:Antineoplastic Agents; D005419:Flavonoids; D007529:Isoflavones; C060298:5,7-dimethoxyflavone