title: Effect of dacryocystorhinostomy on systemic adverse effects of topical timolol maleate.
abstract: OBJECTIVE
  To evaluate whether transformation of the naso-lacrimal passage as happens after dacryocystorhinostomy (DCR) operation has any effect on the systemic adverse effects of topically administered timolol maleate.
  
  
  METHODS
  Fifty otherwise healthy adult patients without any prior history of cardiac or pulmonary problems scheduled for elective DCR surgery received a drop of timolol maleate 0.5% on the healthy eye. This eye served as a control. Six weeks after successful DCR surgery, the operated eye received the same medication. Parameters compared included intraocular pressure (IOP), pulse rate, blood pressure and forced expiratory volume in the first second (FEV1) findings.
  
  
  METHODS
  Post DCR patients showed an increased incidence of reduced pulse rate and FEV1.
  
  
  CONCLUSIONS
  Timolol maleate ophthalmic preparation should be used with caution in post-DCR patients.
authors.affiliation: Ruby General Hospital, Kolkata, India.
authors.forename: Kakoli
authors.initials: K
authors.lastname: Roy
authors.forename: Kanchan Kumar
authors.initials: KK
authors.lastname: Mondal
authors.forename: Biswarup
authors.initials: B
authors.lastname: Ray
authors.forename: Soumen
authors.initials: S
authors.lastname: Chakraborty
authors.forename: Supreeti
authors.initials: S
authors.lastname: Biswas
authors.forename: Bijoy Kumar
authors.initials: BK
authors.lastname: Baral
mesh_terms: D000287:Administration, Topical; D000319:Adrenergic beta-Antagonists / Q000009:adverse effects* / Q000493:pharmacokinetics; D000328:Adult; D000075202:Contraindications; D003608:Dacryocystorhinostomy / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D009798:Ocular Hypertension / Q000139:chemically induced*; D009883:Ophthalmic Solutions; D013999:Timolol / Q000009:adverse effects* / Q000493:pharmacokinetics
chemical_list: D000319:Adrenergic beta-Antagonists; D009883:Ophthalmic Solutions; D013999:Timolol