title: Modeling the dynamic epigenome: from histone modifications towards self-organizing chromatin.
abstract: Epigenetic mechanisms play an important role in regulating and stabilizing functional states of living cells. However, in spite of an increasing amount of experimental data, models of transcriptional regulation by epigenetic processes, in particular by histone modifications, are rather rare. In this article, we focus on epigenetic modes of transcriptional regulation based on histone modifications and their potential dynamical interplay with DNA methylation and higher-order chromatin structure. The main purpose of this article is to review recent formal modeling approaches to the dynamics and propagation of histone modifications and to relate them to available experimental data. We evaluate their assumptions with respect to recruitment of relevant modifiers, establishment and processing of modifications, and compare the emerging stability properties and memory effects. Theoretical predictions that await experimental validation are highlighted and potential extensions of these models towards multiscale models of self-organizing chromatin are discussed.
authors.affiliation: Interdisciplinary Centre for Bioinformatics, University Leipzig, D-04107 Leipzig, Härtelstr. 16-18, Germany.
authors.forename: Thimo
authors.initials: T
authors.lastname: Rohlf
authors.forename: Lydia
authors.initials: L
authors.lastname: Steiner
authors.forename: Jens
authors.initials: J
authors.lastname: Przybilla
authors.forename: Sonja
authors.initials: S
authors.lastname: Prohaska
authors.forename: Hans
authors.initials: H
authors.lastname: Binder
authors.forename: Jörg
authors.initials: J
authors.lastname: Galle
mesh_terms: D002843:Chromatin / Q000378:metabolism*; D042002:Chromatin Assembly and Disassembly; D019175:DNA Methylation; D044127:Epigenesis, Genetic; D006657:Histones / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D012568:Schizosaccharomyces / Q000378:metabolism
chemical_list: D002843:Chromatin; D006657:Histones