title: Risk factors that affect the treatment of interstitial cystitis using intravesical therapy with a dimethyl sulfoxide cocktail.
abstract: OBJECTIVE
  Dimethyl sulfoxide (DMSO) bladder instillation is a standard therapy for interstitial cystitis (IC); however, there are varying degrees of success. We hypothesize that first-line intravesical therapy with a DMSO cocktail will optimize treatment outcome.
  
  
  METHODS
  Ninety women with newly diagnosed IC were enrolled consecutively for the treatment. The IC symptom and problem index was used as an outcome measure.
  
  
  RESULTS
  Six (6.7%) patients dropped out of the treatment due to intolerable bladder irritation. Fifty-five (65.5%) of the remaining 84 patients, who completed the treatment, experienced ≧50% symptomatic improvement. After a regression analysis, three clinical variables were found to affect treatment adversely, i.e., the presence of advanced cystoscopic glomerulations, microscopic hematuria, and urodynamic detrusor underactivity, respectively.
  
  
  CONCLUSIONS
  Our results suggest bladder instillation with a DMSO cocktail may well be considered as first-line therapy for IC patients. However, there exists a subgroup of nonresponders who may have severe disease.
authors.affiliation: Department of Obstetrics and Gynecology, Taichung Veterans General Hospital, No. 160, Section 3, Taichung Harbor Road, Taichung 40705, Taiwan. mjhung@vghtc.gov.tw
authors.forename: Man-Jung
authors.initials: MJ
authors.lastname: Hung
authors.forename: Yi-Ting
authors.initials: YT
authors.lastname: Chen
authors.forename: Pao-Sheng
authors.initials: PS
authors.lastname: Shen
authors.forename: Shih-Tien
authors.initials: ST
authors.lastname: Hsu
authors.forename: Gin-Den
authors.initials: GD
authors.lastname: Chen
authors.forename: Esther Shih-Chu
authors.initials: ES
authors.lastname: Ho
mesh_terms: D000283:Administration, Intravesical; D000328:Adult; D018856:Cystitis, Interstitial / Q000188:drug therapy* / Q000503:physiopathology; D004121:Dimethyl Sulfoxide / Q000008:administration & dosage* / Q000627:therapeutic use*; D005260:Female; D016166:Free Radical Scavengers / Q000008:administration & dosage / Q000627:therapeutic use; D006417:Hematuria / Q000150:complications*; D006801:Humans; D007674:Kidney Diseases / Q000150:complications*; D008875:Middle Aged; D012044:Regression Analysis; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome; D001745:Urinary Bladder Diseases / Q000150:complications*; D014563:Urodynamics / Q000502:physiology
chemical_list: D016166:Free Radical Scavengers; D004121:Dimethyl Sulfoxide