title: Conservation and innovation in Tetrahymena membrane traffic: proteins, lipids, and compartments.
abstract: The past decade has seen a significant expansion in our understanding of membrane traffic in Tetrahymena thermophila, facilitated by the development of new experimental tools and by the availability of the macronuclear genome sequence. Here we review studies on multiple pathways of uptake and secretion, as well as work on metabolism of membrane lipids. We discuss evidence for conservation versus innovation in the mechanisms used in ciliates compared with those in other eukaryotic lineages, and raise the possibility that existing gene expression databases can be exploited to analyze specific pathways of membrane traffic in these cells.
authors.affiliation: Cátedra de Biotecnología y Microbiología Industrial, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956, (C1113AAD) Buenos Aires, Argentina.
authors.forename: Alejandro D
authors.initials: AD
authors.lastname: Nusblat
authors.forename: Lydia J
authors.initials: LJ
authors.lastname: Bright
authors.forename: Aaron P
authors.initials: AP
authors.lastname: Turkewitz
mesh_terms: D015415:Biomarkers / Q000737:chemistry; D002462:Cell Membrane / Q000737:chemistry* / Q000235:genetics; D034281:Dynamins / Q000737:chemistry / Q000235:genetics; D017125:Genes, Protozoan; D008563:Membrane Lipids / Q000737:chemistry*; D008565:Membrane Proteins / Q000737:chemistry* / Q000235:genetics; D010587:Phagocytosis; D010588:Phagosomes / Q000737:chemistry; D021381:Protein Transport; D020543:Proteome / Q000032:analysis / Q000737:chemistry; D015800:Protozoan Proteins / Q000737:chemistry* / Q000235:genetics; D013045:Species Specificity; D016808:Tetrahymena thermophila / Q000737:chemistry* / Q000235:genetics; D020691:rab GTP-Binding Proteins / Q000737:chemistry / Q000235:genetics
chemical_list: D015415:Biomarkers; D008563:Membrane Lipids; D008565:Membrane Proteins; D020543:Proteome; D015800:Protozoan Proteins; D020691:rab GTP-Binding Proteins; D034281:Dynamins