title: The role of thromboelastography in directing blood product usage in infant open heart surgery.
abstract: OBJECTIVE
  : Thromboelastography (TEG) measures the dynamics of clot formation in whole blood and provides data that can guide specific blood component therapy. This study analyzed whether the implementation of TEG affected blood product utilization and overall hemostasis in infants (6 months and younger) undergoing open heart surgery.
  
  
  METHODS
  : TEG values measured include R (time to fibrin formation), angle (fibrinogen formation), and MA (platelet function). Blood product usage, TEG values, and operative parameters were collected during surgery on 112 consecutive infants (66 acyanotic) undergoing open heart surgery within the first 6 months of life. Controls consisted of chart data on 70 consecutive patients (57 acyanotic) undergoing the same surgical procedures before implementation of TEG (pre-TEG).
  
  
  RESULTS
  : Using TEG, the pattern of blood product utilization changed. Compared with the pre-TEG era, TEG era patients demonstrated a significant increase in fresh frozen plasma usage intraoperatively (4.74 vs. 1.83 mL/kg; P < 0.001) and reduced postoperative use of platelets (1.69 vs. 3.74 mL/kg; P = 0.006) and cryoprecipitate (0.89 vs. 1.95 mL/kg; P = 0.149). Chest tube drainage was significantly reduced at 1, 2, and 24 hours in the TEG group.TEG angle and MA measurements suggest that fibrinogen and platelets of cyanotic patients are more sensitive to hemodilution than the acyanotic patients.
  
  
  CONCLUSIONS
  : TEG allows for proactive, goal-directed blood component therapy with improved postoperative hemostasis in infants undergoing cardiopulmonary bypass.
authors.affiliation: From the *Medical City Dallas Children's Hospital; †Cardiopulmonary Research Science and Technology Institute; ‡Medical City Dallas Hospital, Dallas, TX USA.
authors.forename: Eric N
authors.initials: EN
authors.lastname: Mendeloff
authors.forename: George F
authors.initials: GF
authors.lastname: Glenn
authors.forename: Paul
authors.initials: P
authors.lastname: Tavakolian
authors.forename: Eugene
authors.initials: E
authors.lastname: Lin
authors.forename: Allison
authors.initials: A
authors.lastname: Leonard
authors.forename: Syma L
authors.initials: SL
authors.lastname: Prince
authors.forename: Morley A
authors.initials: MA
authors.lastname: Herbert