title: Absorption, pharmacokinetics and disposition properties of solid lipid nanoparticles (SLNs).
abstract: In recent years, many researchers have paid more and more attentions on the use of Nanotechnology. Solid lipid nanoparticles (SLNs) are emerged as a promising alternation herein to emulsions, liposomes, microparticles and polymeric nanoparticles for their advantages. As promising drug carrier systems, SLNs are valuable for nanomedicine and have been widely used as delivery systems mostly for drugs and macromolecules like proteins, oligonucleotides and DNA by various application routes, such as intravenous, oral, duodenalous, intramuscular, pulmonary, intranasal, ocular, rectal and intraperitoneal administrations. It has been shown that SLNs can increase bioavailability, alter pharmacokinetic parameters and tissue distribution of the drug loaded. In this review, we will primarily focus on the absorption, pharmacokinetics and disposition properties of SLNs for their possible applications in drug delivery.
authors.affiliation: State Key Laboratory of Oral Diseases, West China College of Stomatology, Sichuan University, No.14 3rd Sec. Ren Min Nan Road, Chengdu, P.R. China.
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.forename: Niansong
authors.initials: N
authors.lastname: Ye
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Luo
authors.forename: Wenli
authors.initials: W
authors.lastname: Lai
authors.forename: Xiaoxiao
authors.initials: X
authors.lastname: Cai
authors.forename: Yunfeng
authors.initials: Y
authors.lastname: Lin
mesh_terms: D000042:Absorption; D000818:Animals; D004337:Drug Carriers / Q000493:pharmacokinetics*; D006801:Humans; D008055:Lipids / Q000493:pharmacokinetics*; D053758:Nanoparticles; D014018:Tissue Distribution
chemical_list: D004337:Drug Carriers; D008055:Lipids