title: MiR-125 in normal and malignant hematopoiesis.
abstract: MiR-125 is a highly conserved microRNA throughout many different species from nematode to humans. In humans, there are three homologs (hsa-miR-125b-1, hsa-miR-125b-2 and hsa-miR-125a). Here we review a recent research on the role of miR-125 in normal and malignant hematopoietic cells. Its high expression in hematopoietic stem cells (HSCs) enhances self-renewal and survival. Its expression in specific subtypes of myeloid and lymphoid leukemias provides resistance to apoptosis and blocks further differentiation. A direct oncogenic role in the hematopoietic system has recently been demonstrated by several mouse models. Targets of miR-125b include key proteins regulating apoptosis, innate immunity, inflammation and hematopoietic differentiation.
authors.affiliation: Department of Pediatric Hemato-Oncology, Functional Genomics and Childhood Leukemia Research, Cancer Research Center, Sheba Medical Center, Tel Hashomer, Ramat Gan, Israel.
authors.forename: L
authors.initials: L
authors.lastname: Shaham
authors.forename: V
authors.initials: V
authors.lastname: Binder
authors.forename: N
authors.initials: N
authors.lastname: Gefen
authors.forename: A
authors.initials: A
authors.lastname: Borkhardt
authors.forename: S
authors.initials: S
authors.lastname: Izraeli
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D019337:Hematologic Neoplasms / Q000235:genetics*; D006410:Hematopoiesis / Q000235:genetics*; D006801:Humans; D051379:Mice; D035683:MicroRNAs / Q000235:genetics*
chemical_list: D035683:MicroRNAs