title: Biophysical modulations of functional connectivity.
abstract: Resting-state low frequency oscillations have been detected in many functional magnetic resonance imaging (MRI) studies and appear to be synchronized between functionally related areas. Converging evidence from MRI and other imaging modalities suggest that this activity has an intrinsic neuronal origin. Multiple consistent networks have been found in large populations, and have been shown to be stable over time. Further, these patterns of functional connectivity have been shown to be altered in healthy controls under various physiological challenges. This review will present the biophysical characterization of functional connectivity, and examine the effects of physical state manipulations (such as anesthesia, fatigue, and aging) in healthy controls.
authors.affiliation: Functional MRI Laboratory, University of Michigan, Ann Arbor, Michigan, USA. spelt@umich.edu
authors.forename: Scott J
authors.initials: SJ
authors.lastname: Peltier
authors.forename: Yash
authors.initials: Y
authors.lastname: Shah
mesh_terms: D000818:Animals; D055592:Biophysical Phenomena / Q000502:physiology*; D001921:Brain / Q000502:physiology*; D005221:Fatigue / Q000503:physiopathology; D006801:Humans; D007858:Learning / Q000502:physiology; D009415:Nerve Net / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology; D012890:Sleep / Q000502:physiology