title: VCC-1 over-expression inhibits cisplatin-induced apoptosis in HepG2 cells.
abstract: Vascular endothelial growth factor-correlated chemokine 1 (VCC-1), a recently described chemokine, is hypothesized to be associated with carcinogenesis. However, the molecular mechanisms by which aberrant VCC-1 expression determines poor outcomes of cancers are unknown. In this study, we found that VCC-1 was highly expressed in hepatocellular carcinoma (HCC) tissue. It was also associated with proliferation of HepG2 cells, and inhibition of cisplatin-induced apoptosis of HepG2 cells. Conversely, down-regulation of VCC-1 in HepG2 cells increased cisplatin-induced apoptosis of HepG2 cells. In summary, these results suggest that VCC-1 is involved in cisplatin-induced apoptosis of HepG2 cells, and also provides some evidence for VCC-1 as a potential cellular target for chemotherapy.
authors.affiliation: School of Biotechnology, Southern Medical University, Guangzhou 510515, China.
authors.forename: Zhitao
authors.initials: Z
authors.lastname: Zhou
authors.forename: Xiao
authors.initials: X
authors.lastname: Lu
authors.forename: Ping
authors.initials: P
authors.lastname: Zhu
authors.forename: Wei
authors.initials: W
authors.lastname: Zhu
authors.forename: Xia
authors.initials: X
authors.lastname: Mu
authors.forename: Rongmei
authors.initials: R
authors.lastname: Qu
authors.forename: Ming
authors.initials: M
authors.lastname: Li
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects* / Q000235:genetics; D006528:Carcinoma, Hepatocellular / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D018925:Chemokines / Q000235:genetics / Q000378:metabolism*; D019743:Chemokines, CXC; D002945:Cisplatin / Q000494:pharmacology*; D019008:Drug Resistance, Neoplasm; D005260:Female; D015870:Gene Expression; D056945:Hep G2 Cells; D006801:Humans; D008113:Liver Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D008297:Male; D008875:Middle Aged
chemical_list: D000970:Antineoplastic Agents; C508524:CXCL17 protein, human; D018925:Chemokines; D019743:Chemokines, CXC; D002945:Cisplatin