title: [Leukemia- and lymphoma-associated flow cytometric, cytogenetic, and molecular genetic aberrations in healthy individuals].
abstract: Most leukemia and lymphoma cases are characterized by specific flow cytometric, cytogenetic and molecular genetic aberrations, which can also be detected in healthy individuals in some cases. The authors review the literature concerning monoclonal B-cell lymphocytosis, and the occurrence of chromosomal translocations t(14;18) and t(11;14), NPM-ALK fusion gene, JAK2 V617F mutation, BCR-ABL1 fusion gene, ETV6-RUNX1(TEL-AML1), MLL-AF4 and PML-RARA fusion gene in healthy individuals. At present, we do not know the importance of these aberrations. From the authors review it is evident that this phenomenon has both theoretical and practical (diagnostic, prognostic, and therapeutic) significance.
authors.affiliation: Jósa András Oktatókórház Egészségügyi Szolgáltató Nonprofit Kft. Hematológiai Osztály Nyíregyháza Lukács Ödön u. 4. 4400. drjakojanos@freemail.hu
authors.forename: János
authors.initials: J
authors.lastname: Jakó
authors.forename: László
authors.initials: L
authors.lastname: Szerafin
mesh_terms: D000208:Acute Disease; D001402:B-Lymphocytes; D016026:Bone Marrow Transplantation; D002869:Chromosome Aberrations; D002908:Chronic Disease; D005434:Flow Cytometry; D006801:Humans; D007938:Leukemia / Q000235:genetics* / Q000473:pathology*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics / Q000473:pathology; D008218:Lymphocytosis / Q000235:genetics / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000235:genetics / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics* / Q000473:pathology*; D008967:Molecular Biology; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D014178:Translocation, Genetic; D014184:Transplantation, Homologous
chemical_list: D015514:Oncogene Proteins, Fusion