title: For MutY, it's all about the OG.
abstract: MutY and its human ortholog, MUTYH, repair a specific form of DNA damage: adenine mis-paired with the oxidatively modified form of deoxyguanosine, 8-oxo-7,8-dihydro-2'-deoxyguanosine. In a recent issue of Chemistry & Biology, Brinkmeyer et al. utilized mutant forms of MutY to reveal the critical residues in MutY that are required for this selectivity and specificity.
authors.affiliation: Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. rws9@pitt.edu
authors.forename: Robert W
authors.initials: RW
authors.lastname: Sobol
mesh_terms: D045647:DNA Glycosylases / Q000378:metabolism*; D006801:Humans
chemical_list: D045647:DNA Glycosylases