title: Steroidal saponins from Fritillaria pallidiflora Schrenk.
abstract: Five new steroidal saponins, Pallidifloside D (1), Pallidifloside E (2), Pallidifloside G (5), Pallidifloside H (6) and Pallidifloside I (7), together with seven other steroidal saponins (3, 4, 8-12) were isolated from the dry bulbs of Fritillaria pallidiflora Schrenk. Their structures were established by spectroscopic techniques (IR, MS, 1D and 2D NMR) and chemical means. The isolated steroidal saponins were evaluated for cyotoxic activity against human C6 brain gliomas and Hela cervix cancer cell lines using MTT assays. Compounds 1, 10, 11, 12 showed cytotoxicity against C6 and Hela cell lines with IC(50) values in the range of 5.1-75.8μM.
authors.affiliation: School of Traditional Chinese Materia Medica 49#, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, PR China.
authors.forename: Shuo
authors.initials: S
authors.lastname: Shen
authors.forename: Guoyu
authors.initials: G
authors.lastname: Li
authors.forename: Jian
authors.initials: J
authors.lastname: Huang
authors.forename: Chaojun
authors.initials: C
authors.lastname: Chen
authors.forename: Bu
authors.initials: B
authors.lastname: Ren
authors.forename: Ga
authors.initials: G
authors.lastname: Lu
authors.forename: Yong
authors.initials: Y
authors.lastname: Tan
authors.forename: Jiaxu
authors.initials: J
authors.lastname: Zhang
authors.forename: Xian
authors.initials: X
authors.lastname: Li
authors.forename: Jinhui
authors.initials: J
authors.lastname: Wang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000188:drug therapy; D005260:Female; D031410:Fritillaria / Q000737:chemistry*; D005910:Glioma / Q000188:drug therapy; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D018517:Plant Roots; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D013256:Steroids / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D012503:Saponins; D013256:Steroids; C000603145:pallidifloside D