title: Atypical, invasive, recurring Crooke cell adenoma of the pituitary.
abstract: We report the case of a 49-year-old woman presenting with Cushing disease and visual disturbance. An atypical, aggressive, invasive pituitary tumor regrew despite several surgeries. Detailed morphologic investigation by histology, immunohistochemistry and electron microscopy documented a Crooke cell adenoma, a rare form of ACTH-producing pituitary tumor. Recognition of such adenomas is of importance given their aggressive behavior and tendency to recur. More studies are needed to explain the pathobiology of this not invariably functional pituitary adenoma.
authors.affiliation: Department of Laboratory Medicine, Division of Pathology, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada. rotondof@smh.ca
authors.forename: Fabio
authors.initials: F
authors.lastname: Rotondo
authors.forename: Michael
authors.initials: M
authors.lastname: Cusimano
authors.forename: Bernd W
authors.initials: BW
authors.lastname: Scheithauer
authors.forename: Claire
authors.initials: C
authors.lastname: Coire
authors.forename: Eva
authors.initials: E
authors.lastname: Horvath
authors.forename: Kalman
authors.initials: K
authors.lastname: Kovacs
mesh_terms: D000236:Adenoma / Q000145:classification* / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D000970:Antineoplastic Agents / Q000627:therapeutic use; D003606:Dacarbazine / Q000031:analogs & derivatives / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000145:classification* / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy; D000077204:Temozolomide
chemical_list: D000970:Antineoplastic Agents; D003606:Dacarbazine; D000077204:Temozolomide