title: [Prediction and screening of CTGF secondary structure and receptor-binding domain].
abstract: OBJECTIVE
  To analyze the secondary structure of connective tissue growth factor (CTGF) for the prediction and screening of candidate receptor-binding domain of CTGF.
  
  
  METHODS
  Bioinformatics method was employed to predict and screen CTGF receptor-binding domain based on the analysis of secondary structure of CTGF, and its hydrophilicity and physical property.
  
  
  RESULTS
  The results showed that the candidate receptor-binding domains locate in 96-102, 104-112, 257-272 segments, the corresponding amino acid sequences are TAKDGAP, IFGGTVYRS and IRTPKISKPIKFELSG, respectively.
  
  
  CONCLUSIONS
  There were 3 candidate receptor-binding domains of CTGF, which might be the targets for newly antagonistic micromolecule polypeptide of CTGF.
authors.affiliation: Department of Urology, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.forename: Yu-Chun
authors.initials: YC
authors.lastname: Zhu
authors.forename: Li
authors.initials: L
authors.lastname: Zhang
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
mesh_terms: D000595:Amino Acid Sequence; D001665:Binding Sites; D055513:Connective Tissue Growth Factor / Q000737:chemistry* / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D011485:Protein Binding; D054730:Protein Interaction Domains and Motifs; D017433:Protein Structure, Secondary
chemical_list: C526317:CCN2 protein, human; D055513:Connective Tissue Growth Factor