title: Prenatal exposure to arsenic and its effects on fetal development in the general population of Dalian.
abstract: To evaluate prenatal exposure to arsenic in the general population and its effects on birth size, we conducted a cross-sectional study in Dalian, China. Arsenic concentration in maternal and cord blood was detected by inductively coupled plasma-mass spectrometry and its effects on birth size were analyzed by multivariate analysis and multiple linear regression analysis. Arsenic concentrations in cord blood were significantly lower than those in maternal blood. A significant positive correlation was shown between maternal and cord blood arsenic concentrations. Maternal arsenic concentration was negatively associated with birth weight, height and chest circumference, and fetal arsenic concentration was negatively associated with head circumference. Our results indicate that arsenic exposure at environmental levels in uterus may pose adverse effects on fetal development.
authors.affiliation: Department of Obstetrics and Gynecology, No. 210 Hospital of PLA, Dalian, Liaoning, China.
authors.forename: Huai
authors.initials: H
authors.lastname: Guan
authors.forename: Fengyuan
authors.initials: F
authors.lastname: Piao
authors.forename: Xuan
authors.initials: X
authors.lastname: Zhang
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Li
authors.forename: Qiujuan
authors.initials: Q
authors.lastname: Li
authors.forename: Lei
authors.initials: L
authors.lastname: Xu
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Kitamura
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Yokoyama
mesh_terms: D000022:Abortion, Spontaneous / Q000453:epidemiology / Q000378:metabolism; D001151:Arsenic / Q000009:adverse effects* / Q000097:blood; D049628:Body Size; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D047109:Fetal Development / Q000187:drug effects*; D005865:Gestational Age; D006257:Head / Q000033:anatomy & histology; D006801:Humans; D016014:Linear Models; D008297:Male; D013058:Mass Spectrometry / Q000379:methods; D018811:Maternal Exposure / Q000009:adverse effects; D015999:Multivariate Analysis; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000453:epidemiology* / Q000378:metabolism
chemical_list: D001151:Arsenic