title: Copper catalyzed cross-coupling of iodobenzoates with bromozinc-difluorophosphonate.
abstract: A copper-catalyzed cross-coupling of iodobenzoates with bromozinc-difluorophosphonate, generated from diethyl bromodifluoromethylphosphonate and zinc in dioxane, is reported. The notable features of this reaction are its high reaction efficiency, excellent functional group compatibility, and operational simplicity. This protocol provides a useful and facile access to aryldifluorophosphonates of interest in life science.
authors.affiliation: Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China.
authors.forename: Zhang
authors.initials: Z
authors.lastname: Feng
authors.forename: Fei
authors.initials: F
authors.lastname: Chen
authors.forename: Xingang
authors.initials: X
authors.lastname: Zhang
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006846:Hydrocarbons, Halogenated / Q000138:chemical synthesis* / Q000737:chemistry; D007463:Iodobenzoates / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000737:chemistry; D015032:Zinc / Q000737:chemistry*
chemical_list: D006846:Hydrocarbons, Halogenated; D007463:Iodobenzoates; D009942:Organometallic Compounds; D063065:Organophosphonates; D003300:Copper; D015032:Zinc