title: Synthesis and biological evaluation of (--)-linarinic acid derivatives as neuroprotective agents against OGD-induced cell damage.
abstract: A series of novel (-)-1,2,3,9-tetrahydropyrrolo[2,1-b]quinazoline-1-carboxylic acid derivatives were designed and synthesized. All of the prepared compounds were screened for their neuroprotective effects using an in vitro oxygen glucose deprivation (OGD) model of ischemic stroke. Some of the target compounds exhibited moderate to excellent protective potency. In particular, compounds 9d, 9e, 9g, and 9h showed significant protective effects in the SH-SY(5) Y cell line at all three concentrations tested.
authors.affiliation: Key Laboratory of Structure-Based Drugs Design & Discovery of Ministry of Education, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Tian
authors.forename: Chao
authors.initials: C
authors.lastname: Ma
authors.forename: Linyin
authors.initials: L
authors.lastname: Feng
authors.forename: Lei
authors.initials: L
authors.lastname: Zhang
authors.forename: Feiyue
authors.initials: F
authors.lastname: Hao
authors.forename: Li
authors.initials: L
authors.lastname: Pan
authors.forename: Maosheng
authors.initials: M
authors.lastname: Cheng
mesh_terms: D002545:Brain Ischemia / Q000188:drug therapy / Q000473:pathology; D018929:Cell Culture Techniques; D015687:Cell Hypoxia / Q000187:drug effects; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003470:Culture Media; D004305:Dose-Response Relationship, Drug; D005947:Glucose / Q000172:deficiency; D006801:Humans; D008954:Models, Biological; D015394:Molecular Structure; D009474:Neurons / Q000187:drug effects* / Q000473:pathology; D018696:Neuroprotective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D010100:Oxygen / Q000378:metabolism; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015427:Reperfusion Injury / Q000473:pathology / Q000517:prevention & control; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: D003470:Culture Media; D018696:Neuroprotective Agents; D011758:Pyrroles; D011799:Quinazolines; D005947:Glucose; D010100:Oxygen