title: Giant intradiploic epidermoid cyst with large osteolytic lesions of the skull: a case report.
abstract: BACKGROUND
  We report a case of tumor growth over a period of four decades, presenting with large multicentric lytic lesions of the skull and a profound mass effect, without neurological deficits. Clinical and radiological features of a patient with a giant intradiploic epidermoid and its impact on the choice of treatments are discussed.
  
  
  METHODS
  An 81-year-old Caucasian man, who had first noticed a painless subcutaneous swelling over the left frontal scalp about 40 years ago, presented after a short episode of dizziness, which he experienced after treatment of focal retinal detachment. Computed tomography (CT) and magnetic resonance imaging (MRI) examinations revealed an exceptionally large tumor involving major parts of the skull with extensive destruction of the bone and distinct deformation of the brain. Considering his age and the absence of neurological deficits or pain, the patient refused the option of tumor removal and cranioplasty, yet agreed to a biopsy, which confirmed the suspected diagnosis.
  
  
  CONCLUSIONS
  The course of the disease demonstrates that even patients with large tumors, inducing distinct pathomorphological changes, do not necessarily experience significant impairment of their quality of life without surgery. This is an impressive example of the chance to lead a long and satisfying life without specific medical treatment, avoiding the inherent risks of these procedures. Yet, there is a clear indication for surgery of intradiploic epidermoids in most cases described in the literature.
authors.affiliation: University Clinic Leipzig, Department of Neurosurgery, Liebigstraße 20 in 04103 Leipzig, Germany. Wolfgang.Krupp@medizin.uni-leipzig.de.
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Krupp
authors.forename: Alexander
authors.initials: A
authors.lastname: Heckert
authors.forename: Heidrun
authors.initials: H
authors.lastname: Holland
authors.forename: Jürgen
authors.initials: J
authors.lastname: Meixensberger
authors.forename: Dominik
authors.initials: D
authors.lastname: Fritzsch