title: CD147 silencing via RNA interference reduces tumor cell invasion, metastasis             and increases chemosensitivity in pancreatic cancer cells.
abstract: CD147, which belongs to the immunoglobulin superfamily, is a multifunctional             glycoprotein that has been shown to increase tumor invasion, metastasis and multidrug             resistance. To define the role of CD147 in invasion and metastasis more precisely,             we utilized gene silencing to inhibit the expression of CD147 in pancreatic cancer             cells. We observed that CD147 expression was significantly impeded at both the             mRNA and protein levels and resulted in a decrease of MMP-2 and MMP-9 activities.             There was also a decrease of MCT1 expression in the invasion and metastasis potential             of pancreatic cancer cells, as well as increased chemosensitivity to gemcitabine             in Panc-1 cells. Overall, these results suggest that CD147 plays an important             role in the invasion, metastasis and chemosensitivity of the human pancreatic             cancer cell line Panc-1, indicating that CD147 may be a promising therapeutic             target for pancreatic cancer.
authors.affiliation: Central Laboratory, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210006, PR China.
authors.forename: Yuqin
authors.initials: Y
authors.lastname: Pan
authors.forename: Bangshun
authors.initials: B
authors.lastname: He
authors.forename: Guoqi
authors.initials: G
authors.lastname: Song
authors.forename: Qian
authors.initials: Q
authors.lastname: Bao
authors.forename: Zhipeng
authors.initials: Z
authors.lastname: Tang
authors.forename: Fuliang
authors.initials: F
authors.lastname: Tian
authors.forename: Shukui
authors.initials: S
authors.lastname: Wang
mesh_terms: D051926:Basigin / Q000235:genetics / Q000502:physiology*; D045744:Cell Line, Tumor; D003841:Deoxycytidine / Q000031:analogs & derivatives / Q000494:pharmacology; D018432:Drug Resistance, Multiple / Q000235:genetics; D019008:Drug Resistance, Neoplasm; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism*; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D027501:Monocarboxylic Acid Transporters / Q000378:metabolism*; D009124:Muscle Proteins / Q000378:metabolism; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D010190:Pancreatic Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D034622:RNA Interference; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D034741:RNA, Small Interfering; D027981:Symporters / Q000378:metabolism*; D000093542:Gemcitabine; D000099233:Monocarboxylate Transport Protein 1
chemical_list: D051926:Basigin; D003841:Deoxycytidine; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9; D027501:Monocarboxylic Acid Transporters; D009124:Muscle Proteins; D012333:RNA, Messenger; D034741:RNA, Small Interfering; D027981:Symporters; D000093542:Gemcitabine; D000099233:Monocarboxylate Transport Protein 1; C406962:SLC16A4 protein, human