title: MicroRNAs in metabolism and metabolic disorders.
abstract: MicroRNAs (miRNAs) have recently emerged as key regulators of metabolism. For example, miR-33a and miR-33b have a crucial role in controlling cholesterol and lipid metabolism in concert with their host genes, the sterol-regulatory element-binding protein (SREBP) transcription factors. Other metabolic miRNAs, such as miR-103 and miR-107, regulate insulin and glucose homeostasis, whereas miRNAs such as miR-34a are emerging as key regulators of hepatic lipid homeostasis. The discovery of circulating miRNAs has highlighted their potential as both endocrine signalling molecules and disease markers. Dysregulation of miRNAs may contribute to metabolic abnormalities, suggesting that miRNAs may potentially serve as therapeutic targets for ameliorating cardiometabolic disorders.
authors.affiliation: Massachusetts General Hospital Cancer Center, Charlestown, Massachusetts 02129, USA.
authors.forename: Veerle
authors.initials: V
authors.lastname: Rottiers
authors.forename: Anders M
authors.initials: AM
authors.lastname: Näär
mesh_terms: D002784:Cholesterol / Q000378:metabolism; D004703:Endocrine System / Q000378:metabolism; D005234:Fatty Liver / Q000235:genetics / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000378:metabolism; D050356:Lipid Metabolism; D008659:Metabolic Diseases / Q000235:genetics* / Q000378:metabolism*; D024821:Metabolic Syndrome / Q000235:genetics / Q000378:metabolism; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D065626:Non-alcoholic Fatty Liver Disease; D009765:Obesity / Q000235:genetics / Q000378:metabolism; D020320:Oligoribonucleotides, Antisense / Q000494:pharmacology; D015398:Signal Transduction; D051779:Sterol Regulatory Element Binding Proteins / Q000235:genetics / Q000378:metabolism
chemical_list: D007328:Insulin; C550416:MIRN33a microRNA, human; D035683:MicroRNAs; D020320:Oligoribonucleotides, Antisense; D051779:Sterol Regulatory Element Binding Proteins; D002784:Cholesterol; D005947:Glucose