title: Charcoal haemoperfusion for paracetamol overdose.
abstract: 1 A controlled trial of charcoal haemoperfusion as an early treatment for paracetamol overdose showed no benefit. 2 The plasma clearances of paracetamol by the charcoal column were variable and disappointingly small (range 4-119 ml/minute). The cumulative amounts removed were also low, mean 1.4 g (range 0.2-5.2 g). 3 No clinical problems were encountered with the technique of haemoperfusion and in particular the drop in blood platelet counts was small (mean fall 16%).
authors.affiliation: The Liver Unit, King's College Hospital and Medical School, Denmark Hill, London.
authors.forename: B G
authors.initials: BG
authors.lastname: Gazzard
authors.forename: R A
authors.initials: RA
authors.lastname: Willison
authors.forename: M J
authors.initials: MJ
authors.lastname: Weston
authors.forename: R P
authors.initials: RP
authors.lastname: Thompson
authors.forename: R
authors.initials: R
authors.lastname: Williams