title: Do adventitial mast cells contribute to the pathogenesis of ascending thoracic aorta aneurysm?
abstract: The precise pathogenesis of the ascending aortic aneurysm (AscAA) remains to be determined. Mast cells in the adventitia of human AscAA lesions may play a role in this pathogenesis. Adventitial mast cell density per 10 high-power fields (0.25 mm(2)) was assessed in multiple biopsy samples, from aneurysmal aortic sections (n = 41) and control (nondilated) aortic specimens (n = 50), stained by orcein-Giemsa method, an inexpensive (<$1) method. In a multivariable adjusted logistic regression model, using AscAA as the dependent variable, mast cell density was found to be an independent predictor of AscAA occurrence (odds ratio = 2.21; 95% confidence interval = 1.58-3.08; P < .001). Receiver operating characteristic curve analysis showed that the proposed cutoff value of ≥ 3 mast cells per 10 high-power fields was very sensitive to detect AscAA occurrence, yielding a sensitivity of 90% with a specificity of 80%. In conclusion, a significant increase in the number of mast cells in the adventitia of human ascending aortic lesions proposes a role for these cells in the pathogenesis of AscAA.
authors.affiliation: Department of Surgical and Clinical Pathology, Tehran University of Medical Sciences, Tehran, Iran. maryamsotoudeh2006@yahoo.com
authors.forename: Maryam Sotoudeh
authors.initials: MS
authors.lastname: Anvari
authors.forename: Mohammad Ali
authors.initials: MA
authors.lastname: Boroumand
authors.forename: Elham Ameli
authors.initials: EA
authors.lastname: Mojarad
authors.forename: Abbasali
authors.initials: A
authors.lastname: Karimi
authors.forename: Kyomars
authors.initials: K
authors.lastname: Abbasi
authors.forename: Mahmood
authors.initials: M
authors.lastname: Shirzad
authors.forename: Abbas Salehi
authors.initials: AS
authors.lastname: Omran
authors.forename: Namvar
authors.initials: N
authors.lastname: Movahedi
authors.forename: Shapour
authors.initials: S
authors.lastname: Shirani
authors.forename: Hamidreza
authors.initials: H
authors.lastname: Goodarzynejad
mesh_terms: D000328:Adult; D063194:Adventitia / Q000473:pathology*; D000368:Aged; D001013:Aorta, Thoracic / Q000473:pathology*; D017545:Aortic Aneurysm, Thoracic / Q000209:etiology* / Q000473:pathology; D002452:Cell Count; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008407:Mast Cells / Q000473:pathology*; D008875:Middle Aged; D011237:Predictive Value of Tests; D012372:ROC Curve; D055815:Young Adult