title: Childhood pars planitis; clinical features and outcomes.
abstract: OBJECTIVE
  To evaluate the demographic and clinical features of childhood pars planitis, and to determine the therapeutic and visual outcomes of the disease.
  
  
  METHODS
  Medical records of pediatric patients (less than 16 years of age at diagnosis) with pars planitis and at least 6 months of follow-up who were referred to Labbafinejad Medical Center, Tehran, Iran over a 22 year period were reviewed.
  
  
  RESULTS
  Overall, 117 eyes of 61 patients including 51 (83.6%) male subjects were included. Mean age at the time of diagnosis was 7.8±3.2 (range, 3-16) years. Mean best corrected visual acuity (BCVA) was 0.88±0.76 logMAR at presentation which improved to 0.39±0.51 logMAR at final visit (P<0.001). Endotheliitis was present in 23 (19.6%) eyes and was significantly more prevalent in subjects younger than 9 years (P=0.025). Cataract formation (41.9%) and cystoid macular edema (19.7%) were the most prevalent complications. Univariate regression analysis showed that better baseline visual acuity (OR=0.38, 95%CI 0.21-0.70, P=0.002), age older than 5 years at disease onset (OR=0.36, 95%CI 0.14-0.9, P=0.029), absence of endotheliitis (OR=0.39, 95%CI 0.15-0.99, P=0.047) and female gender (OR=3.77, 95%CI 1.03-13.93, P=0.046) were significantly associated with final BCVA of 20/40 or better.
  
  
  CONCLUSIONS
  Childhood pars planitis was much more common among male subjects. Endotheliitis may be a sign of inflammation spillover and is more prevalent in younger patients. Visual prognosis is favorable in most patients with appropriate treatment.
authors.affiliation: Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Homayoon
authors.initials: H
authors.lastname: Nikkhah
authors.forename: Alireza
authors.initials: A
authors.lastname: Ramezani
authors.forename: Hamid
authors.initials: H
authors.lastname: Ahmadieh
authors.forename: Masoud
authors.initials: M
authors.lastname: Soheilian
authors.forename: Mohsen
authors.initials: M
authors.lastname: Azarmina
authors.forename: Mohammad-Hossein
authors.initials: MH
authors.lastname: Dehghan
authors.forename: Siamak
authors.initials: S
authors.lastname: Moradian
authors.forename: Ramin
authors.initials: R
authors.lastname: Nourinia