title: Integration of radioembolisation into multimodal treatment of liver-dominant metastatic colorectal cancer.
abstract: BACKGROUND
  Radioembolisation (selective internal radiation therapy; SIRT), as part of a continuous strategy contributed to the improvement in response rates and median survival for unresectable metastatic colorectal cancer. Therefore, the role of SIRT in the different stages of treatment plan was investigated in this review.
  
  
  METHODS
  After a brief description of the principles of SIRT, the review focused on the clinical evidences of published trials on the current experience of radioembolisation and its role in both salvage setting and earlier lines of chemotherapy.
  
  
  CONCLUSIONS
  Evidence from Phase I studies and small Phase II/III randomised controlled trials has provided an early signal of the safety and improved overall survival, which can be achieved with radioembolisation and chemotherapy compared with chemotherapy (alone), due to an improved liver control. In the salvage setting, interesting results were observed in term of response, toxicity and median overall survival. Until the results of these early-line randomised trials will be available, radioembolisation could be considered either alone or combined with an appropriate chemotherapy regimen following failure of first- or second-line therapy.
authors.affiliation: Regina Elena National Cancer Institute, Division of Hepato-bilio-pancreatic Surgery, Via Elio Chianesi 53, 00144 Roma, Italy. mcosimelli@libero.it
authors.forename: Maurizio
authors.initials: M
authors.lastname: Cosimelli
authors.forename: Raffaello
authors.initials: R
authors.lastname: Mancini
authors.forename: Livio
authors.initials: L
authors.lastname: Carpanese
authors.forename: Rosa
authors.initials: R
authors.lastname: Sciuto
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Pizzi
authors.forename: Giada
authors.initials: G
authors.lastname: Pattaro
authors.forename: Carlo Ludovico
authors.initials: CL
authors.lastname: Maini
mesh_terms: D015179:Colorectal Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D019008:Drug Resistance, Neoplasm; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000532:radiotherapy* / Q000556:secondary