title: Rh2(S-biTISP)2-catalyzed asymmetric functionalization of indoles and pyrroles with vinylcarbenoids.
abstract: Asymmetric functionalization of N-heterocycles by vinylcarbenoids in the presence of catalytic amounts of Rh(2)(S-biTISP)(2) has been successfully developed. This bridged dirhodium catalyst not only selectively enforces the reaction to occur at the vinylogous position of the carbenoid but also affords high levels of asymmetric induction.
authors.affiliation: Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, USA.
authors.forename: Yajing
authors.initials: Y
authors.lastname: Lian
authors.forename: Huw M L
authors.initials: HM
authors.lastname: Davies
mesh_terms: D000478:Alkylation; D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*; D014753:Vinyl Compounds / Q000737:chemistry*
chemical_list: D007211:Indoles; D009942:Organometallic Compounds; D011758:Pyrroles; D014753:Vinyl Compounds; D012238:Rhodium