title: Decreased expression of MHC class II and cathepsin E in dendritic cells might contribute to impaired induction of antigen-specific T cell response in NC/Nga mice.
abstract: NC/Nga (NC) mice are an animal model for human atopic dermatitis. We found that induction of antigen (Ag)-specific T cell response is diminished in ovalbumin (OVA)-immunized NC mice. Ability of Ag presentation in NC mouse dendritic cells (DCs) was significantly weaker than that in BALB/c and DBA/2 mouse DCs. Expression levels of MHC class II molecules and cathepsin E in NC mouse DCs were significantly lower that those in BALB/c and DBA/2 mouse DCs. These results indicate that low expression levels of MHC class II and cathepsin E might contribute to the defect in induction of Ag-specific T cells in NC mice.
authors.affiliation: Department of Public Health and Applied Nutrition, Institution of Health Bioscience, the University of Tokushima Graduate School, Tokushima, Japan.
authors.forename: Tohru
authors.initials: T
authors.lastname: Sakai
authors.forename: Emi
authors.initials: E
authors.lastname: Shuto
authors.forename: Tomoyo
authors.initials: T
authors.lastname: Taki
authors.forename: Honami
authors.initials: H
authors.lastname: Imamura
authors.forename: Miku
authors.initials: M
authors.lastname: Kioka
authors.forename: Akiko
authors.initials: A
authors.lastname: Nakamoto
authors.forename: Seiji
authors.initials: S
authors.lastname: Mizoguchi
authors.forename: Shouko
authors.initials: S
authors.lastname: Amano
authors.forename: Yukari
authors.initials: Y
authors.lastname: Kawano
authors.forename: Mariko
authors.initials: M
authors.lastname: Nakamoto
authors.forename: Rie
authors.initials: R
authors.lastname: Tsutumi
authors.forename: Toshio
authors.initials: T
authors.lastname: Hosaka
mesh_terms: D000818:Animals; D020059:Cathepsin E / Q000235:genetics* / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology*; D003876:Dermatitis, Atopic / Q000235:genetics / Q000276:immunology*; D004195:Disease Models, Animal; D005260:Female; D000949:Histocompatibility Antigens Class II / Q000235:genetics* / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D010047:Ovalbumin / Q000276:immunology / Q000494:pharmacology; D013045:Species Specificity; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D000949:Histocompatibility Antigens Class II; D010047:Ovalbumin; D020059:Cathepsin E; C533926:Ctse protein, mouse