title: No consistent evidence for association between mtDNA variants and Alzheimer disease.
abstract: OBJECTIVE
  Although several studies have described an association between Alzheimer disease (AD) and genetic variation of mitochondrial DNA (mtDNA), each has implicated different mtDNA variants, so the role of mtDNA in the etiology of AD remains uncertain.
  
  
  METHODS
  We tested 138 mtDNA variants for association with AD in a powerful sample of 4,133 AD case patients and 1,602 matched controls from 3 Caucasian populations. Of the total population, 3,250 case patients and 1,221 elderly controls met the quality control criteria and were included in the analysis.
  
  
  RESULTS
  In the largest study to date, we failed to replicate the published findings. Meta-analysis of the available data showed no evidence of an association with AD.
  
  
  CONCLUSIONS
  The current evidence linking common mtDNA variations with AD is not compelling.
authors.affiliation: Institute of Genetic Medicine, Newcastle University, Central Parkway, Newcastle upon Tyne, UK.
authors.forename: G
authors.initials: G
authors.lastname: Hudson
authors.forename: R
authors.initials: R
authors.lastname: Sims
authors.forename: D
authors.initials: D
authors.lastname: Harold
authors.forename: J
authors.initials: J
authors.lastname: Chapman
authors.forename: P
authors.initials: P
authors.lastname: Hollingworth
authors.forename: A
authors.initials: A
authors.lastname: Gerrish
authors.forename: G
authors.initials: G
authors.lastname: Russo
authors.forename: M
authors.initials: M
authors.lastname: Hamshere
authors.forename: V
authors.initials: V
authors.lastname: Moskvina
authors.forename: N
authors.initials: N
authors.lastname: Jones
authors.forename: C
authors.initials: C
authors.lastname: Thomas
authors.forename: A
authors.initials: A
authors.lastname: Stretton
authors.forename: P A
authors.initials: PA
authors.lastname: Holmans
authors.forename: M C
authors.initials: MC
authors.lastname: O'Donovan
authors.forename: M J
authors.initials: MJ
authors.lastname: Owen
authors.forename: J
authors.initials: J
authors.lastname: Williams
authors.forename: P F
authors.initials: PF
authors.lastname: Chinnery
mesh_terms: D000544:Alzheimer Disease / Q000175:diagnosis / Q000235:genetics*; D015331:Cohort Studies; D004272:DNA, Mitochondrial / Q000235:genetics*; D056726:Genetic Association Studies / Q000379:methods*; D014644:Genetic Variation / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics
chemical_list: D004272:DNA, Mitochondrial