title: Parenthood in patients with acute promyelocytic leukemia after treatment with arsenic trioxide: a case series.
abstract: Arsenic trioxide, believed to be a carcinogen and a teratogen, has found its niche in the treatment of acute promyelocytic leukemia (APL). APL is a disease affecting young patients. Post-treatment fertility and outcome of pregnancy are always a concern in a disease with high cure rates. We report a case series of six patients who were treated successfully for APL with arsenic trioxide and who parented at least one healthy offspring after completing their treatment.
authors.affiliation: Disease Management Group, Tata Memorial Centre, Mumbai, India.
authors.forename: Shilpa
authors.initials: S
authors.lastname: Gupta
authors.forename: Bhausaheb
authors.initials: B
authors.lastname: Bagel
authors.forename: Sumeet
authors.initials: S
authors.lastname: Gujral
authors.forename: P G
authors.initials: PG
authors.lastname: Subramanian
authors.forename: Navin
authors.initials: N
authors.lastname: Khattry
authors.forename: Hari
authors.initials: H
authors.lastname: Menon
authors.forename: Reena
authors.initials: R
authors.lastname: Nair
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D000077237:Arsenic Trioxide; D001152:Arsenicals / Q000009:adverse effects*; D005260:Female; D005298:Fertility / Q000187:drug effects*; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy*; D008297:Male; D010087:Oxides / Q000009:adverse effects*; D011247:Pregnancy; D011256:Pregnancy Outcome
chemical_list: D000970:Antineoplastic Agents; D001152:Arsenicals; D010087:Oxides; D000077237:Arsenic Trioxide