title: Triterpene saponins from the roots of Dipsacus asper and their protective effects against the Aβ(25-35) induced cytotoxicity in PC12 cells.
abstract: Three new triterpene saponins, named asperosaponin A-C (1-3), together with seven known triterpene saponins (4-10) were isolated from the roots of Dipsacus asper. The structures of compounds 1-3 were elucidated on the basis of detailed spectroscopic analysis and chemical methods. Compounds 1-3, 6-10 had significantly protective effects in PC12 cells against the Aβ(25-35) induced cytotoxicity. All the compounds isolated showed no cytotoxic activity against three human cancer cell lines, A-549, Bel-7402 and BGC-823.
authors.affiliation: State Key Laboratory of Natural Products and Functions, China Pharmaceutical University, Ministry of Education, Nanjing, PR China.
authors.forename: De
authors.initials: D
authors.lastname: Ji
authors.forename: Yue
authors.initials: Y
authors.lastname: Wu
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
authors.forename: Chun-Feng
authors.initials: CF
authors.lastname: Zhang
authors.forename: Zhong-Lin
authors.initials: ZL
authors.lastname: Yang
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000139:chemically induced / Q000188:drug therapy*; D016229:Amyloid beta-Peptides; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D049917:Dipsacaceae / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D016716:PC12 Cells; D010446:Peptide Fragments; D010673:Pheochromocytoma / Q000139:chemically induced / Q000188:drug therapy*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D018517:Plant Roots / Q000737:chemistry; D051381:Rats; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: C575145:3-O-(3',4'-O-acetyl)-arabinopyranosyl hederagenin 28-O-glucopyranosyl-(1-6)-glucopyranoside; C575144:3-O-arabinopyranosyl hederagenin 28-O-glucopyranosyl-(1-6)-glucopyranoside (3-C-28); C575146:3-O-arabinopyranosyl oleanolic acid; D016229:Amyloid beta-Peptides; D000972:Antineoplastic Agents, Phytogenic; D010446:Peptide Fragments; D010936:Plant Extracts; D012503:Saponins