title: Magnetic Fe3O4@mesoporous silica composites for drug delivery and bioadsorption.
abstract: Magnetic Fe(3)O(4)@mesoporous silica (MS) composites were synthesized by generating Fe(3)O(4) nanoparticles in the mesoporous silica matrix using the sol-gel method in nitrogen atmosphere. The mesoporous silica hosts include SBA-15 particles owning highly ordered p6mm mesostructure, siliceous mesostructured cellular foams (MCFs), and fiber-like mesoporous silica (FMS) with unique pore structures. The X-ray diffraction (XRD), transmission electron microscopy (TEM), and N(2) adsorption/desorption results show that Fe(3)O(4) functionalized MCFs and FMS possess suitable mesoporous structure for the adsorption of both small-molecular drug and large biomolecules. The biocompatibility tests on L929 fibroblast cells using MTT assay reveal low cytotoxicity of these systems. These Fe(3)O(4)@mesoporous silica composites show sustained release properties for aspirin in vitro. The release of the aspirin molecules from the pores of the Fe(3)O(4)@mesoporous silica composites is basically a diffusive process. Fe(3)O(4)@MCFs and Fe(3)O(4)@FMS owning larger pore size are good candidates for the adsorption of bovine serum albumin (BSA). These magnetic composites can be potential vectors for drug delivery and bioadsorption.
authors.affiliation: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Huang
authors.forename: Chunxia
authors.initials: C
authors.lastname: Li
authors.forename: Ziyong
authors.initials: Z
authors.lastname: Cheng
authors.forename: Yong
authors.initials: Y
authors.lastname: Fan
authors.forename: Piaoping
authors.initials: P
authors.lastname: Yang
authors.forename: Cuimiao
authors.initials: C
authors.lastname: Zhang
authors.forename: Kuiyue
authors.initials: K
authors.lastname: Yang
authors.forename: Jun
authors.initials: J
authors.lastname: Lin
mesh_terms: D000327:Adsorption; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D001241:Aspirin / Q000008:administration & dosage*; D002417:Cattle; D002470:Cell Survival; D002522:Chlorocebus aethiops; D004337:Drug Carriers / Q000737:chemistry*; D005290:Ferric Compounds / Q000737:chemistry* / Q000633:toxicity; D059346:Magnets / Q000737:chemistry* / Q000633:toxicity; D012710:Serum Albumin, Bovine / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry* / Q000633:toxicity; D014709:Vero Cells; D014961:X-Ray Diffraction
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004337:Drug Carriers; D005290:Ferric Compounds; C509969:SBA-15; C000499:ferric oxide; D012710:Serum Albumin, Bovine; D012822:Silicon Dioxide; D001241:Aspirin