title: Immunohistochemical study of metaplastic carcinoma and central acellular carcinoma of the breast: central acellular carcinoma is related to metaplastic carcinoma.
abstract: Metaplastic breast cancers (MBCs) [spindle cell carcinoma (SpCC), squamous cell carcinoma (SCC), and matrix-producing carcinoma (MPC)] and invasive carcinomas with central acellular zones (CACs) were analyzed with respect to biological potential by immunohistochemical analyses. Specimens from 40 patients [20 with MBCs (7 with SCC, 6 with SpCC, 5 with MPC, and 2 with mixed type)] and 20 with CACs were analyzed using antibodies to cytokeratin (CK) 8, 5/6, 14, AE1/AE3, 34αE12, involucrin, c-kit, vimentin (VIM), alpha-smooth muscle actin, p63, epidermal growth factor receptor, epithelial cell adhesion molecule, and estrogen receptor (ER)/progesterone receptor (PR)/HER2. Expression of CK5/6, 34βE12, VIM, nuclear p63, and cytoplasmic p63 was significantly higher with MBCs than CACs (38%/13%, 70%/43%, 85%/33%, 68%/40%, and 48%/18%, respectively). Other markers were expressed at various levels in these tumors, but the difference between them was not significant. Eighteen MBC and 8 CAC cases were triple (ER/PR/HER2) negative; 17 MBCs and 7 CACs were basal-like tumors. Several differences were seen in MBCs and CACs, but they were heterogeneous, differentiating multipotentially into mesenchymal, myoepithelial, basal-like phenotypes with "stem cell-like" features. Thus, CACs are related to MBCs by immunohistochemical analyses as well as according to morphological findings.
authors.affiliation: Department of Pathology, Kurume University School of Medicine, 67 Asahi-machi, Kurume, 830-0011, Japan. rin@med.kurume-u.ac.jp
authors.forename: Rin
authors.initials: R
authors.lastname: Yamaguchi
authors.forename: Maki
authors.initials: M
authors.lastname: Tanaka
authors.forename: Keiko
authors.initials: K
authors.lastname: Kondo
authors.forename: Toshiro
authors.initials: T
authors.lastname: Yokoyama
authors.forename: Ichiro
authors.initials: I
authors.lastname: Maeda
authors.forename: Shin-Ichi
authors.initials: S
authors.lastname: Tsuchiya
authors.forename: Miki
authors.initials: M
authors.lastname: Yamaguchi
authors.forename: Ryuji
authors.initials: R
authors.lastname: Takahashi
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Ogata
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Abe
authors.forename: Jun
authors.initials: J
authors.lastname: Akiba
authors.forename: Osamu
authors.initials: O
authors.lastname: Nakashima
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Kage
authors.forename: Hirohisa
authors.initials: H
authors.lastname: Yano
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism*; D001943:Breast Neoplasms / Q000145:classification* / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D002277:Carcinoma / Q000145:classification* / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D002280:Basal Cell Carcinoma / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008679:Metaplasia; D014463:Ultrasonography
chemical_list: D014408:Biomarkers, Tumor