title: Characterization of colicin M and its orthologs targeting bacterial cell wall peptidoglycan biosynthesis.
abstract: For a long time, colicin M was known for killing susceptible Escherichia coli cells by interfering with cell wall peptidoglycan biosynthesis, but its precise mode of action was only recently elucidated: this bacterial toxin was demonstrated to be an enzyme that catalyzes the specific degradation of peptidoglycan lipid intermediate II, thereby provoking the arrest of peptidoglycan synthesis and cell lysis. The discovery of this activity renewed the interest in this colicin and opened the way for biochemical and structural analyses of this new class of enzyme (phosphoesterase). The identification of a few orthologs produced by pathogenic strains of Pseudomonas further enlarged the field of investigation. The present article aims at reviewing recently acquired knowledge on the biology of this small family of bacteriocins.
authors.affiliation: Institut de Biochimie et Biophysique Moléculaire et Cellulaire, Université Paris-Sud , UMR 8619 CNRS, Orsay, France.
authors.forename: Hélène
authors.initials: H
authors.lastname: Barreteau
authors.forename: Meriem
authors.initials: M
authors.lastname: El Ghachi
authors.forename: Aurélie
authors.initials: A
authors.lastname: Barnéoud-Arnoulet
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Sacco
authors.forename: Thierry
authors.initials: T
authors.lastname: Touzé
authors.forename: Denis
authors.initials: D
authors.lastname: Duché
authors.forename: Fabien
authors.initials: F
authors.lastname: Gérard
authors.forename: Mark
authors.initials: M
authors.lastname: Brooks
authors.forename: Delphine
authors.initials: D
authors.lastname: Patin
authors.forename: Ahmed
authors.initials: A
authors.lastname: Bouhss
authors.forename: Didier
authors.initials: D
authors.lastname: Blanot
authors.forename: Herman
authors.initials: H
authors.lastname: van Tilbeurgh
authors.forename: Michel
authors.initials: M
authors.lastname: Arthur
authors.forename: Roland
authors.initials: R
authors.lastname: Lloubès
authors.forename: Dominique
authors.initials: D
authors.lastname: Mengin-Lecreulx
mesh_terms: D001430:Bacteriocins / Q000378:metabolism* / Q000494:pharmacology; D002473:Cell Wall / Q000737:chemistry / Q000378:metabolism*; D003087:Colicins / Q000378:metabolism* / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D008958:Models, Molecular; D010457:Peptidoglycan / Q000096:biosynthesis*; D017434:Protein Structure, Tertiary; D011549:Pseudomonas / Q000235:genetics / Q000378:metabolism; D013379:Substrate Specificity; D014538:Uridine Diphosphate N-Acetylmuramic Acid / Q000031:analogs & derivatives* / Q000378:metabolism
chemical_list: D001430:Bacteriocins; D003087:Colicins; D010457:Peptidoglycan; D014538:Uridine Diphosphate N-Acetylmuramic Acid; C069249:muramyl-NAc-(pentapeptide)pyrophosphoryl-undecaprenol