title: Contribution of complement factor H Y402H polymorphism to sudden sensorineural hearing loss risk and possible interaction with diabetes.
abstract: Sudden sensorineural hearing loss (SSNHL) is one of the most common diseases encountered by otolaryngologists; however, the etiology is unclear. The aim of this study was to assess the association between SSNHL and polymorphism of complement factor H (CFH) Y402H, which is implicated in age-related macular degeneration. We conducted a case-control study, in which the cases were 72 SSNHL patients and the controls were 2161 residents selected randomly from the resident register. The odds ratio (OR) for SSNHL risk was determined using the additive-genetic model of CFH Y402H polymorphism. The OR for SSNHL risk was 1.788 (95% confidence interval [CI]: 1.008-3.172) with no adjustments and 1.820 (CI: 1.025-3.232) after adjusting for age and sex. Of the three lifestyle-related diseases hypertension, dyslipidemia, and diabetes, only diabetes was significantly associated with SSNHL risk. We classified both the controls and SSNHL patients into those with or without diabetes, and the OR for SSNHL risk was 6.326 (CI: 1.885-21.225) in diabetic subjects and 1.214 (CI: 0.581-2.538) in nondiabetic subjects. We conclude that CFH Y402H polymorphism and SSNHL risk are significantly related, and that diabetic CFH Y402H minor allele carriers may be susceptible to SSNHL.
authors.affiliation: Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan. naokin@med.nagoya-u.ac.jp
authors.forename: Naoki
authors.initials: N
authors.lastname: Nishio
authors.forename: Masaaki
authors.initials: M
authors.lastname: Teranishi
authors.forename: Yasue
authors.initials: Y
authors.lastname: Uchida
authors.forename: Saiko
authors.initials: S
authors.lastname: Sugiura
authors.forename: Fujiko
authors.initials: F
authors.lastname: Ando
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shimokata
authors.forename: Michihiko
authors.initials: M
authors.lastname: Sone
authors.forename: Hironao
authors.initials: H
authors.lastname: Otake
authors.forename: Ken
authors.initials: K
authors.lastname: Kato
authors.forename: Tadao
authors.initials: T
authors.lastname: Yoshida
authors.forename: Mitsuhiko
authors.initials: M
authors.lastname: Tagaya
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Hibi
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Nakashima
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019943:Amino Acid Substitution / Q000235:genetics / Q000502:physiology; D016022:Case-Control Studies; D017242:Complement Factor H / Q000235:genetics*; D048909:Diabetes Complications / Q000235:genetics*; D005260:Female; D059647:Gene-Environment Interaction; D020022:Genetic Predisposition to Disease; D006319:Hearing Loss, Sensorineural / Q000150:complications / Q000235:genetics*; D003639:Hearing Loss, Sudden / Q000150:complications / Q000235:genetics*; D006639:Histidine / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000502:physiology; D014443:Tyrosine / Q000235:genetics; D055815:Young Adult
chemical_list: D014443:Tyrosine; D006639:Histidine; D017242:Complement Factor H