title: Serum levels of calcitonin gene-related peptide and substance P are decreased in patients with diabetes mellitus and coronary artery disease.
abstract: OBJECTIVE
  This study evaluated serum levels of the neuropeptides calcitonin gene-related peptide (CGRP) and substance P (SP) in coronary artery disease (CAD) patients with and without a history of diabetes mellitus (DM).
  
  
  METHODS
  Patients undergoing coronary angiography for suspected myocardial ischaemia were divided into four groups depending on their clinical status: control group (no CAD or DM; n=44), DM group (DM without CAD; n=46), CAD group (stable CAD without DM; n=44) and DM+CAD group (stable CAD with DM; n=50). Serum levels of CGRP and SP were determined using radioimmunoassays.
  
  
  RESULTS
  CGRP and SP levels in the DM and CAD groups were significantly lower than in the control group. The lowest levels of CGRP and SP were observed in the DM+CAD group. There were no significant differences in CGRP and SP levels between the DM group and the CAD group.
  
  
  CONCLUSIONS
  CGRP and SP may have a role in the pathogenesis of CAD in patients with diabetes.
authors.affiliation: Department of Cardiovascular Sciences, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
authors.forename: L H
authors.initials: LH
authors.lastname: Wang
authors.forename: S X
authors.initials: SX
authors.lastname: Zhou
authors.forename: R C
authors.initials: RC
authors.lastname: Li
authors.forename: L R
authors.initials: LR
authors.lastname: Zheng
authors.forename: J H
authors.initials: JH
authors.lastname: Zhu
authors.forename: S J
authors.initials: SJ
authors.lastname: Hu
authors.forename: Y L
authors.initials: YL
authors.lastname: Sun
mesh_terms: D002116:Calcitonin / Q000097:blood*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood* / Q000150:complications* / Q000000981:diagnostic imaging; D003710:Demography; D048909:Diabetes Complications / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood / Q000150:complications; D011498:Protein Precursors / Q000097:blood*; D013373:Substance P / Q000097:blood*
chemical_list: D011498:Protein Precursors; D013373:Substance P; D002116:Calcitonin