title: Utilization of photoinduced charge-separated state of donor-acceptor-linked molecules for regulation of cell membrane potential and ion transport.
abstract: The control of ion transport across cell membranes by light is an attractive strategy that allows targeted, fast control of precisely defined events in the biological membrane. Here we report a novel general strategy for the control of membrane potential and ion transport by using charge-separation molecules and light. Delivery of charge-separation molecules to the plasma membrane of PC12 cells by a membranous nanocarrier and subsequent light irradiation led to depolarization of the membrane potential as well as inhibition of the potassium ion flow across the membrane. Photoregulation of the cell membrane potential and ion transport by using charge-separation molecules is highly promising for control of cell functions.
authors.affiliation: Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan.
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Numata
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Murakami
authors.forename: Fumiaki
authors.initials: F
authors.lastname: Kawashima
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Morone
authors.forename: John E
authors.initials: JE
authors.lastname: Heuser
authors.forename: Yuta
authors.initials: Y
authors.lastname: Takano
authors.forename: Kei
authors.initials: K
authors.lastname: Ohkubo
authors.forename: Shunichi
authors.initials: S
authors.lastname: Fukuzumi
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Mori
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Imahori
mesh_terms: D000818:Animals; D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism*; D017136:Ion Transport; D007477:Ions; D008027:Light; D008564:Membrane Potentials; D008854:Microscopy, Electron / Q000379:methods; D008956:Models, Chemical; D008968:Molecular Conformation; D009474:Neurons / Q000378:metabolism; D016716:PC12 Cells; D010777:Photochemistry / Q000379:methods*; D011188:Potassium / Q000737:chemistry; D015221:Potassium Channels / Q000737:chemistry; D051381:Rats; D013997:Time Factors
chemical_list: D007477:Ions; D015221:Potassium Channels; D011188:Potassium