title: Comparison of ovarian FMR1 genotypes and sub-genotypes in oocyte donors and infertile women.
abstract: OBJECTIVE
  We recently described ovarian genotypes and sub-genotypes of the FMR1 gene with distinctly associated ovarian aging patterns, which in infertile women follow a typical X-linked distribution pattern. Whether normally fertile women, however, also demonstrate the same distribution, is unknown.
  
  
  METHODS
  We, therefore, investigated ovarian FMR1 genotype and sub-genotype distribution in 182 oocyte donor candidates in comparison to 339 infertile controls. As previously reported, genotype designation was made, based on a normal range of CGG ( n = 26-34) (median 30), defining women as normal (norm), heterozygous (het) or homozygous (hom). Het and hom genotypes were further subdivided into sub-genotypes, based on whether abnormal alleles were above (high) or below normal range (low).
  
  
  RESULTS
  Oocyte donors presented with 47.8% norm, 45.1% het and 7.1% hom genotypes, confirming a typical X-linked distribution pattern. They, however, still subtly differed from infertility patients, especially in het sub-genotypes.
  
  
  CONCLUSIONS
  These findings validate recently newly described ovarian genotypes and sub-genotypes, reaffirming their relevance to female fertility/infertility.
authors.affiliation: The Center for Human Reproduction, 21 East 69th Street, New York, NY 10021, USA. ykizawa@centerforhumanreprod.com
authors.forename: Norbert
authors.initials: N
authors.lastname: Gleicher
authors.forename: Andrea
authors.initials: A
authors.lastname: Weghofer
authors.forename: Ann
authors.initials: A
authors.lastname: Kim
authors.forename: David H
authors.initials: DH
authors.lastname: Barad
mesh_terms: D000328:Adult; D000367:Age Factors; D005260:Female; D051860:Fragile X Messenger Ribonucleoprotein 1 / Q000235:genetics*; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D007247:Infertility, Female / Q000235:genetics*; D009865:Oocytes / Q000502:physiology*; D014019:Tissue Donors
chemical_list: D051860:Fragile X Messenger Ribonucleoprotein 1; C497683:FMR1 protein, human