title: Biocompatibility of polymethylmethacrylate resins used in dentistry.
abstract: Biocompatibility or tissue compatibility describes the ability of a material to perform with an appropriate host response when applied as intended. Poly-methylmethacrylate (PMMA) based resins are most widely used resins in dentistry, especially in fabrication of dentures and orthodontic appliances. They are considered cytotoxic on account of leaching of various potential toxic substances, most common being residual monomer. Various in vitro and in vivo experiments and cell based studies conducted on acrylic based resins or their leached components have shown them to have cytotoxic effects. They can cause mucosal irritation and tissue sensitization. These studies are not only important to evaluate the long term clinical effect of these materials, but also help in further development of alternate resins. This article reviews information from scientific full articles, reviews, or abstracts published in dental literature, associated with biocompatibility of PMMA resins and it is leached out components. Published materials were searched in dental literature using general and specialist databases, like the PubMED database.
authors.affiliation: Department of Prosthodontics, Faculty of Dental Sciences, CSM Medical University (upgraded KGMC), Lucknow, India.
authors.forename: Rupali
authors.initials: R
authors.lastname: Gautam
authors.forename: Raghuwar D
authors.initials: RD
authors.lastname: Singh
authors.forename: Vinod P
authors.initials: VP
authors.lastname: Sharma
authors.forename: Ramashanker
authors.initials: R
authors.lastname: Siddhartha
authors.forename: Pooran
authors.initials: P
authors.lastname: Chand
authors.forename: Rakesh
authors.initials: R
authors.lastname: Kumar
mesh_terms: D006801:Humans; D019904:Polymethyl Methacrylate / Q000009:adverse effects* / Q000737:chemistry* / Q000627:therapeutic use*; D039781:PubMed; D012117:Resins, Synthetic / Q000009:adverse effects* / Q000737:chemistry* / Q000627:therapeutic use*
chemical_list: D012117:Resins, Synthetic; D019904:Polymethyl Methacrylate