title: Leukocyte and cardiac phosphoinositide 3-kinase γ activity in pressure overload-induced cardiac failure.
abstract: Class IB phosphoinositide 3-kinase p110γ is a master regulator of both leukocyte and cardiomyocyte function. Whereas in the immune system p110γ is principally involved in the control of leukocyte chemotaxis and inflammatory reactions, in cardiomyocytes p110γ affects multiple aspects of β-adrenergic receptor signaling and cardiac function. Because inflammatory cell recruitment/activation and cardiac dysfunction are strictly connected, p110γ has recently been revealed as a promising target for drug design in the treatment of heart failure. This review discusses recent works that dissect the relative contribution of leukocyte p110γ and its cardiac counterpart in the onset and progression of pressure overload-induced cardiac remodeling and the ensuing therapeutic implications.
authors.affiliation: Department of Genetics, Biology and Biochemistry, Molecular Biotechnology Center, University of Torino, 10126 Torino, Italy.
authors.forename: Alessia
authors.initials: A
authors.lastname: Perino
authors.forename: Alessandra
authors.initials: A
authors.lastname: Ghigo
authors.forename: Emilio
authors.initials: E
authors.lastname: Hirsch
mesh_terms: D000818:Animals; D006333:Heart Failure / Q000209:etiology / Q000378:metabolism*; D006801:Humans; D007962:Leukocytes / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D032383:Myocytes, Cardiac / Q000378:metabolism; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology; D020257:Ventricular Remodeling / Q000502:physiology*
chemical_list: D019869:Phosphatidylinositol 3-Kinases