title: Single polymorphism nucleotide rs1333049 on chromosome 9p21 is associated with carotid plaques but not with common carotid intima-media thickness in older adults. A combined analysis of the Three-City and the EVA studies.
abstract: OBJECTIVE
  To address the relationship of rs1333049, the 9p21 variant showing the strongest association with coronary heart disease (CHD), with carotid plaques and plaque-free common carotid artery intima-media thickness (CCA-IMT) in older adults from 2 French population-based cohorts.
  
  
  METHODS
  We genotyped for rs1333049, 4097 CHD-free participants including 3191 aged 65-86 years from the Three-City (3C) Study and 906 aged 59-71 years from the Vascular Aging Study (EVA). Plaque-free mean CCA-IMT and the presence of carotid plaques were assessed.
  
  
  RESULTS
  In multivariate analysis, each C allele copy of rs1333049 was associated with baseline carotid plaques (odds ratio (OR)=1.24; 95% confidence interval (CI)=1.13-1.36; p<0.001) but not with baseline CCA-IMT (p=0.19). Among the EVA participants, the C allele was associated with 4-year plaques progression (p=0.04) but not with CCA-IMT progression.
  
  
  CONCLUSIONS
  The chromosome 9p21 locus might influence CHD risk through carotid plaques development.
authors.affiliation: Inserm, U970, Paris Cardiovascular Research Centre, PARCC, University Paris Descartes, Sorbonne Paris Cité, UMR-S970, Paris, France. matthieu.plichart@inserm.fr
authors.forename: Matthieu
authors.initials: M
authors.lastname: Plichart
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Empana
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Lambert
authors.forename: Philippe
authors.initials: P
authors.lastname: Amouyel
authors.forename: Laurence
authors.initials: L
authors.lastname: Tiret
authors.forename: Luc
authors.initials: L
authors.lastname: Letenneur
authors.forename: Claudine
authors.initials: C
authors.lastname: Berr
authors.forename: Christophe
authors.initials: C
authors.lastname: Tzourio
authors.forename: Pierre
authors.initials: P
authors.lastname: Ducimetière
mesh_terms: D000368:Aged; D017536:Carotid Artery, Common / Q000000981:diagnostic imaging; D059168:Carotid Intima-Media Thickness; D016893:Carotid Stenosis / Q000000981:diagnostic imaging / Q000235:genetics*; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D003327:Coronary Disease / Q000000981:diagnostic imaging; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide