title: Cohort profile: the Themba Lethu Clinical Cohort, Johannesburg, South Africa.
abstract: The Themba Lethu Clinical Cohort was established in 2004 to allow large patient-level analyses from a single HIV treatment site to evaluate National Treatment Guidelines, answer questions of national and international policy relevance and to combine an economic and epidemiologic focus on HIV research. The current objectives of the Themba Lethu Clinical Cohort analyses are to: (i) provide cohort-level information on the outcomes of HIV treatment; (ii) evaluate aspects of HIV care and treatment that have policy relevance; (iii) evaluate the cost and cost-effectiveness of different approaches to HIV care and treatment; and (iv) provide a platform for studies on improving HIV care and treatment. Since 2004, Themba Lethu Clinic has enrolled approximately 30,000 HIV-positive patients into its HIV care and treatment programme, over 21,000 of whom have received anti-retroviral therapy since being enrolled. Patients on treatment are typically seen at least every 3 months with laboratory monitoring every 6 months to 1 year. The data collected include demographics, clinical visit data, laboratory data, medication history and clinical diagnoses. Requests for collaborations on analyses can be submitted to our data centre.
authors.affiliation: Centre for Global Health and Development, Boston University, Boston, MA, USA.
authors.forename: Matthew P
authors.initials: MP
authors.lastname: Fox
authors.forename: Mhairi
authors.initials: M
authors.lastname: Maskew
authors.forename: A Patrick
authors.initials: AP
authors.lastname: MacPhail
authors.forename: Lawrence
authors.initials: L
authors.lastname: Long
authors.forename: Alana T
authors.initials: AT
authors.lastname: Brennan
authors.forename: Daniel
authors.initials: D
authors.lastname: Westreich
authors.forename: William B
authors.initials: WB
authors.lastname: MacLeod
authors.forename: Pappie
authors.initials: P
authors.lastname: Majuba
authors.forename: Ian M
authors.initials: IM
authors.lastname: Sanne
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D018791:CD4 Lymphocyte Count; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000453:epidemiology; D006801:Humans; D008297:Male; D017410:Practice Guidelines as Topic; D015397:Program Evaluation; D012959:Socioeconomic Factors; D013019:South Africa / Q000453:epidemiology; D016896:Treatment Outcome; D019562:Viral Load
chemical_list: D019380:Anti-HIV Agents