title: Design and synthesis of thiourea derivatives containing a benzo[5,6]cyclohepta[1,2-b]pyridine moiety as potential antitumor and anti-inflammatory agents.
abstract: Thiourea derivatives (6a-e) were developed and screened for antitumor and anti-inflammatory activity. Most of the compounds exhibited growth inhibitory effects comparable to 5-fluorouracil in vitro against mammary (MCF-7 and MDA-MB 231) as well as colon (HT-29) carcinoma cells. They also showed stronger anti-inflammatory activity than ibuprofen in vivo in the xylene-induced ear swelling assay in mice.
authors.affiliation: Department of Medicinal Chemistry, China Pharmaceutical University, Tongjia Xiang 24, Nanjing, PR China.
authors.forename: Wukun
authors.initials: W
authors.lastname: Liu
authors.forename: Jinpei
authors.initials: J
authors.lastname: Zhou
authors.forename: Tong
authors.initials: T
authors.lastname: Zhang
authors.forename: Haiyang
authors.initials: H
authors.lastname: Zhu
authors.forename: Hai
authors.initials: H
authors.lastname: Qian
authors.forename: Huibin
authors.initials: H
authors.lastname: Zhang
authors.forename: Wenlong
authors.initials: W
authors.lastname: Huang
authors.forename: Ronald
authors.initials: R
authors.lastname: Gust
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001681:Biological Assay; D001943:Breast Neoplasms / Q000188:drug therapy*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D003110:Colonic Neoplasms / Q000188:drug therapy*; D003500:Cyclization; D004195:Disease Models, Animal; D015195:Drug Design; D005260:Female; D006801:Humans; D020128:Inhibitory Concentration 50; D051379:Mice; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013890:Thiourea / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D011743:Pyrimidines; D013890:Thiourea