title: Dangerous liaisons: mitochondrial DNA meets the NLRP3 inflammasome.
abstract: Danger signals released by damaged organelles can promote inflammation. In this issue of Immunity, Shimada et al. (2012) report that oxidized DNA, released by mitochondria, directly binds and activates the NLRP3 inflammasome.
authors.affiliation: Department of Biochemistry, University of Lausanne, 155 Ch. Des Boveresses, Epalinges 1066, Switzerland. fabio.martinon@unil.ch
authors.forename: Fabio
authors.initials: F
authors.lastname: Martinon