title: Cyclic diarylheptanoids as inhibitors of NO production from Acer nikoense.
abstract: We prepared a series of acerogenins A and B derivatives as inhibitors of nitric oxide (NO) production in vitro. Our results suggested that an ester group at a hydroxyl at C-2 improved inhibitory effects without cytotoxicity. A benzoyl ester derivative of acerogenin C showed the most potent inhibitory activity of NO production from lipopolysaccharide-activated macrophages.
authors.affiliation: Faculty of Pharmaceutical Sciences, Hoshi University, Shinagawa-ku, Tokyo, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Deguchi
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Motegi
authors.forename: Asami
authors.initials: A
authors.lastname: Nakata
authors.forename: Takahiro
authors.initials: T
authors.lastname: Hosoya
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Morita
mesh_terms: D031002:Acer / Q000187:drug effects* / Q000378:metabolism*; D036381:Diarylheptanoids / Q000737:chemistry* / Q000494:pharmacology*; D009569:Nitric Oxide / Q000378:metabolism*
chemical_list: D036381:Diarylheptanoids; D009569:Nitric Oxide