title: [The marker of discogenic diseases of the nervous system in the cerebrospinal fluid].
abstract: Using a novel diagnostic technology that allows to investigate the structure of a biological fluid formed during its phase transition into a dried film, we revealed a cause of mistaken results of protein concentrations in the cerebrospinal fluid of patients with discogenic radiculitis. The traditional laboratory study does not reveal the elevated content of protein in patients with discogenic radiculitis and hernia of invertebral discs due to its more active binding with salts with the following sedimentation during centrifugation. It can be explained by the involvement of salt crystals in the formation of the inert organic-mineral aggregate with protein molecules which structure was changed by dystrophy, ischemia, hypoxia, mechanic damage, tumor process. The aggregate is characterized by abnormally tight links. This phenomenon is known as biomineralization, the universal mechanism preventing the organism from toxic effects of products of degraded tissues.
authors.forename: S N
authors.initials: SN
authors.lastname: Shatokhina
authors.forename: V S
authors.initials: VS
authors.lastname: Kuznetsova
authors.forename: V N
authors.initials: VN
authors.lastname: Shabalin
mesh_terms: D015415:Biomarkers / Q000134:cerebrospinal fluid; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis*; D006801:Humans; D055959:Intervertebral Disc Degeneration / Q000134:cerebrospinal fluid*; D007405:Intervertebral Disc Displacement / Q000134:cerebrospinal fluid*; D012492:Salts / Q000134:cerebrospinal fluid / Q000737:chemistry
chemical_list: D015415:Biomarkers; D002556:Cerebrospinal Fluid Proteins; D012492:Salts