title: Early effect of oral administration of omeprazole with mosapride as compared with those of omeprazole alone on the intragastric pH.
abstract: BACKGROUND
  The ideal medication for acid-related diseases should have a rapid onset of action to promote hemostasis and cause efficient resolution of symptoms. The aim of our study was to comparatively investigate the inhibitory effect on gastric acid secretion of a single oral administration of omeprazole plus mosapride with that of omeprazole alone.
  
  
  METHODS
  Ten Helicobacter pylori-negative male subjects participated in this randomized, two-way crossover study. Intragastric pH was monitored continuously for 6 hours after a single oral administration of omeprazole 20 mg or that of omeprazole 20 mg plus mosapride 5 mg (the omeprazole being administered one hour after the mosapride). Each administration was separated by a 7-days washout period.
  
  
  RESULTS
  The average pH during the 6-hour period after administration of omeprazole 20 mg plus mosapride 5 mg was higher than that after administration of omeprazole 20 mg alone (median: 3.22 versus 4.21, respectively; p = 0.0247).
  
  
  CONCLUSIONS
  In H. pylori -negative healthy male subjects, an oral dose of omeprazole 20 mg plus mosapride 5 mg increased the intragastric pH more rapidly than omeprazole 20 mg alone.
authors.affiliation: Yokohama City University School of Medicine, Yokohama, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Iida
authors.forename: Masahiko
authors.initials: M
authors.lastname: Inamori
authors.forename: Tetsuro
authors.initials: T
authors.lastname: Fujii
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Sekino
authors.forename: Hiroki
authors.initials: H
authors.lastname: Endo
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Hosono
authors.forename: Takashi
authors.initials: T
authors.lastname: Nonaka
authors.forename: Tomoko
authors.initials: T
authors.lastname: Koide
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Takahashi
authors.forename: Masato
authors.initials: M
authors.lastname: Yoneda
authors.forename: Ayumu
authors.initials: A
authors.lastname: Goto
authors.forename: Yasunobu
authors.initials: Y
authors.lastname: Abe
authors.forename: Noritoshi
authors.initials: N
authors.lastname: Kobayashi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kirikoshi
authors.forename: Kensuke
authors.initials: K
authors.lastname: Kubota
authors.forename: Satoru
authors.initials: S
authors.lastname: Saito
authors.forename: Eiji
authors.initials: E
authors.lastname: Gotoh
authors.forename: Shin
authors.initials: S
authors.lastname: Maeda
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nakajima
mesh_terms: D000328:Adult; D001549:Benzamides / Q000494:pharmacology*; D004357:Drug Synergism; D005744:Gastric Acid / Q000378:metabolism*; D005745:Gastric Acidity Determination; D005750:Gastric Juice / Q000737:chemistry; D005765:Gastrointestinal Agents / Q000494:pharmacology*; D006801:Humans; D006863:Hydrogen-Ion Concentration / Q000187:drug effects; D008297:Male; D009025:Morpholines / Q000494:pharmacology*; D009853:Omeprazole / Q000494:pharmacology*; D054328:Proton Pump Inhibitors / Q000494:pharmacology*; D018709:Statistics, Nonparametric; D055815:Young Adult
chemical_list: D001549:Benzamides; D005765:Gastrointestinal Agents; D009025:Morpholines; D054328:Proton Pump Inhibitors; C062720:mosapride; D009853:Omeprazole