title: Two new sesquiterpene lactones from the supercritical fluid extract of Centipeda minima.
abstract: Two new sesquiterpene lactones, minimolides G(1) and H(2), were isolated from the supercritical fluid extract of Centipeda minima. Their structures were elucidated on the basis of extensive analyses of spectroscopic data including IR, HR-ESI-MS, 1D and 2D NMR. Compounds 1 and 2 displayed inhibitory activity against human nasopharyngeal cancer cell line (CNE) with IC₅₀ values of 61.4 and 28.7 μM, respectively.
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou 510632, China.
authors.forename: Peng
authors.initials: P
authors.lastname: Wu
authors.forename: Xiao-Guang
authors.initials: XG
authors.lastname: Li
authors.forename: Ning
authors.initials: N
authors.lastname: Liang
authors.forename: Guo-Cai
authors.initials: GC
authors.lastname: Wang
authors.forename: Wen-Cai
authors.initials: WC
authors.lastname: Ye
authors.forename: Guang-Xiong
authors.initials: GX
authors.lastname: Zhou
authors.forename: Yao-Lan
authors.initials: YL
authors.lastname: Li
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D025924:Chromatography, Supercritical Fluid; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D045788:Sesquiterpenes, Germacrane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D007783:Lactones; D045788:Sesquiterpenes, Germacrane; C574071:minimolide G; C574072:minimolide H