title: Bone responses to simvastatin-loaded porous implant surfaces in an ovariectomized model.
abstract: OBJECTIVE
  The purpose of this study was to investigate bone responses to simvastatin-loaded porous implant surfaces in an ovariectomized model.
  
  
  METHODS
  Roughened implants were divided into a control group (n = 32), test group 1 (n = 32), and test group 2 (n = 32). Test implants were immersed into 10?7 mol/L (test group 1) or 10?6 mol/L (test group 2) simvastatin solutions for drug adsorption onto implant surfaces. Forty-eight ovariectomized rats randomly received an implant in each tibia. One, 2, 4, and 12 weeks later, the tibiae were retrieved and prepared for histomorphometric evaluation. Bone-to-implant contact and bone area around the implant were determined, and histologic observations were made.
  
  
  RESULTS
  New bone formation on test implant surfaces was seen after 1 week, while it was seen on the control implant surface after 2 weeks. There was more bone tissue and bone-to-implant contact along the test implant surfaces than along the control implant surface. The test group 1 and test group 2 implants showed significantly greater bone area and bone-to-implant contact compared to the control implant at all observed time points (P < .05). No differences were found between the two types of test group implants after 1, 2, 4, and 12 weeks (P > .05).
  
  
  CONCLUSIONS
  Simvastatin-loaded porous implant surfaces have the potential to improve implant osseointegration in an ovariectomized rat model.
authors.affiliation: Department of Implantology, Stomatology Hospital, School of Medicine, Zhejiang University, Hagzhou, China.
authors.forename: Guoli
authors.initials: G
authors.lastname: Yang
authors.forename: Lina
authors.initials: L
authors.lastname: Song
authors.forename: Caihong
authors.initials: C
authors.lastname: Guo
authors.forename: Shifang
authors.initials: S
authors.lastname: Zhao
authors.forename: Li
authors.initials: L
authors.lastname: Liu
authors.forename: Fuming
authors.initials: F
authors.lastname: He
mesh_terms: D000134:Acid Etching, Dental / Q000379:methods; D000327:Adsorption; D000818:Animals; D045662:Dental Etching / Q000379:methods; D015921:Dental Implants; D017267:Dental Prosthesis Design; D004195:Disease Models, Animal; D005260:Female; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000008:administration & dosage*; D016348:Osseointegration / Q000187:drug effects; D010012:Osteogenesis / Q000187:drug effects; D010024:Osteoporosis / Q000503:physiopathology / Q000601:surgery; D010027:Osteotomy / Q000379:methods; D010052:Ovariectomy; D016062:Porosity; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D019821:Simvastatin / Q000008:administration & dosage*; D013977:Tibia / Q000187:drug effects* / Q000473:pathology / Q000601:surgery; D013997:Time Factors
chemical_list: D015921:Dental Implants; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D019821:Simvastatin