title: MR imaging findings of the corpus callosum region in the differentiation between multiple sclerosis and neuromyelitis optica.
abstract: OBJECTIVE
  To evaluate MR imaging findings in corpus callosum region for the discrimination between opticospinal multiple sclerosis (OSMS) and neuromyelitis optica (NMO).
  
  
  METHODS
  Forty-two definite OSMS with seronegative NMO-IgG and 23 NMO with seropositive NMO-IgG, and 27 age-matched normal controls (NC) were recruited. Sagittal T2-FLAIR images with 2-mm slice thickness were obtained. Subcallosal dot-dash (SCDD) sign and subcallosal striations (SCS) sign were reviewed.
  
  
  RESULTS
  SCDD was more commonly detected in OSMS (28 of 42 patients) than in NMO (5 of 23 patients) (P<0.05). SCS showed no difference between OSMS (31 of 42 patients) and NMO (12 of 23 patients) (P>0.05). For comparing ROC analysis among SCDD, SCS, and SCDD+SCS for predicted probability through binary logistic regression analysis, SCDD+SCS had the largest area under ROC curve (0.777) than SCDD (0.725) and SCS (0.608).
  
  
  CONCLUSIONS
  SCDD may be helpful in distinguishing OSMS from NMO. The regression equation may also be a simple and effective method of choice for the differentiation between OSMS and NMO.
authors.affiliation: Department of Radiology, PLA General Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, 28 Fuxing Road, Beijing 100853, China. yyqf@hotmail.com
authors.forename: Zhiye
authors.initials: Z
authors.lastname: Chen
authors.forename: Feng
authors.initials: F
authors.lastname: Feng
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.forename: Jinfeng
authors.initials: J
authors.lastname: Li
authors.forename: Lin
authors.initials: L
authors.lastname: Ma
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003337:Corpus Callosum / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000473:pathology*; D009471:Neuromyelitis Optica / Q000473:pathology*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D055815:Young Adult