title: Palladium-catalyzed ortho-arylation of benzamides via direct sp(2) C-H bond activation.
abstract: The palladium-catalyzed ortho-arylation of benzamides by aryl iodides has been demonstrated with the simplest amide CONH(2) as a directing group for the first time. This protocol can be applied to various benzamides and aryl iodides with both electron-donating and electron-withdrawing groups. In addition, the synthesized biphenyl-2-carboxamides can be further transformed to other biphenyl derivatives such as nitriles, carboxylic acids, carbamates, and amines.
authors.affiliation: CAS Key Laboratory of Soft Matter Chemistry, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, PR China.
authors.forename: Dan-Dan
authors.initials: DD
authors.lastname: Li
authors.forename: Ting-Ting
authors.initials: TT
authors.lastname: Yuan
authors.forename: Guan-Wu
authors.initials: GW
authors.lastname: Wang
mesh_terms: D001549:Benzamides / Q000737:chemistry*; D001713:Biphenyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D006860:Hydrogen Bonding; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
chemical_list: D001549:Benzamides; D001713:Biphenyl Compounds; D010165:Palladium