title: Effect of the dopamine D3 receptor antagonist GSK598809 on brain responses to rewarding food images in overweight and obese binge eaters.
abstract: The dopamine D(3) receptor is thought to be a potential target for treating compulsive disorders such as drug addiction and obesity. Here, we used functional Magnetic Resonance Imaging (fMRI) to investigate the effects the selective dopamine D(3) receptor antagonist GSK598809 on brain activation to food images in a sample of overweight and obese binge-eating subjects. Consistent with previous studies, processing of food images was associated with activation of a network of reward areas including the amygdala, striatum and insula. However, brain activation to food images was not modulated by GSK598809. The results demonstrate that D(3) receptor manipulation does not modulate brain responses to food images in overweight and obese subjects.
authors.affiliation: Experimental Medicine, GlaxoSmithKline Pharmaceuticals, Clinical Unit Cambridge, Addenbrooke's Centre for Clinical Investigation, Box 128, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK. chris.m.dodds@gsk.com
authors.forename: Chris M
authors.initials: CM
authors.lastname: Dodds
authors.forename: Barry
authors.initials: B
authors.lastname: O'Neill
authors.forename: John
authors.initials: J
authors.lastname: Beaver
authors.forename: Aidan
authors.initials: A
authors.lastname: Makwana
authors.forename: Massimo
authors.initials: M
authors.lastname: Bani
authors.forename: Emilio
authors.initials: E
authors.lastname: Merlo-Pich
authors.forename: Paul C
authors.initials: PC
authors.lastname: Fletcher
authors.forename: Annelize
authors.initials: A
authors.lastname: Koch
authors.forename: Edward T
authors.initials: ET
authors.lastname: Bullmore
authors.forename: Pradeep J
authors.initials: PJ
authors.lastname: Nathan
mesh_terms: D000293:Adolescent; D000328:Adult; D000679:Amygdala / Q000187:drug effects* / Q000502:physiology; D056912:Binge-Eating Disorder / Q000378:metabolism / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000187:drug effects* / Q000502:physiology; D003342:Corpus Striatum / Q000187:drug effects* / Q000502:physiology; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000503:physiopathology; D050177:Overweight / Q000503:physiopathology; D050637:Receptors, Dopamine D3 / Q000037:antagonists & inhibitors*; D012201:Reward; D055815:Young Adult
chemical_list: D050637:Receptors, Dopamine D3