title: Phenolic compounds from Nicotiana tabacum and their biological activities.
abstract: Three new phenolic compounds, nicotphenols A-C (1-3), together with 14 known phenols (4-17), were isolated from the leaves of Nicotiana tabacum. Their structures were established by means of spectroscopic methods, including extensive 1D and 2D NMR techniques. Compounds 1-3 were tested for their anti-HIV-1 activities and cytotoxicities. They all showed significant cytotoxic abilities and modest anti-HIV-1 activities, respectively.
authors.affiliation: Key Laboratory of Tobacco Chemistry of Yunnan Province, Yunnan Academy of Tobacco Science, Kunming, 650106, China.
authors.forename: Yong-Kuan
authors.initials: YK
authors.lastname: Chen
authors.forename: Xue-Sen
authors.initials: XS
authors.lastname: Li
authors.forename: Guang-Yu
authors.initials: GY
authors.lastname: Yang
authors.forename: Zhang-Yu
authors.initials: ZY
authors.lastname: Chen
authors.forename: Qiu-Fen
authors.initials: QF
authors.lastname: Hu
authors.forename: Ming-Ming
authors.initials: MM
authors.lastname: Miao
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D014026:Nicotiana / Q000737:chemistry*
chemical_list: D019380:Anti-HIV Agents; D004365:Drugs, Chinese Herbal; D010636:Phenols; C573204:nicotphenol A; C573205:nicotphenol B; C573206:nicotphenol C