title: Comparison of the Adult Comorbidity Evaluation 27 and the Charlson Comorbidity indices in patients with laryngeal squamous cell carcinoma.
abstract: OBJECTIVE
  This study aimed to compare the prognostic impact of comorbidity grading by the Adult Comorbidity Evaluation 27 index and the Charlson Comorbidity Index on the five-year overall and disease-specific survival in patients undergoing surgery for laryngeal squamous cell carcinoma.
  
  
  METHODS
  The impact of comorbidity and other factors on survival was examined retrospectively in a group of 177 patients with previously untreated tumour stage one to four laryngeal squamous cell carcinoma surgically treated at the Clinic of Otorhinolaryngology and Maxillofacial Surgery, Clinical Centre of Serbia, between 2000 and 2003. The Cox proportional hazard model was used to identify independent prognostic factors.
  
  
  RESULTS
  On univariate analysis, comorbidity had an impact on prognosis regardless of which index was used. On multivariate analysis, the significant predictors of patients' five-year overall and disease-specific survival were tumour-node-metastasis stage and comorbidity as graded by the Adult Comorbidity Evaluation 27 index.
  
  
  CONCLUSIONS
  The Adult Comorbidity Evaluation 27 index is a more reliable predictor of survival than the Charlson Comorbidity Index in patients with laryngeal squamous cell carcinoma.
authors.affiliation: School of Medicine, University of Belgrade, Serbia. snesic@sbb.rs
authors.forename: V S
authors.initials: VS
authors.lastname: Nesic
authors.forename: Z M
authors.initials: ZM
authors.lastname: Petrovic
authors.forename: S B
authors.initials: SB
authors.lastname: Sipetic
authors.forename: S D
authors.initials: SD
authors.lastname: Jesic
authors.forename: I A
authors.initials: IA
authors.lastname: Soldatovic
authors.forename: D A
authors.initials: DA
authors.lastname: Kastratovic
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology; D015897:Comorbidity; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D007822:Laryngeal Neoplasms / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D012720:Severity of Illness Index; D016019:Survival Analysis