title: Fabrication of ellagic acid incorporated self-assembled peptide microtubes and their applications.
abstract: Ellagic acid (EA), a plant polyphenol known for its wide-range of health benefits was encapsulated within self-assembled threonine based peptide microtubes. The microtubes were assembled using the synthesized precursor bolaamphiphile bis(N-α-amido threonine)-1,5-pentane dicarboxylate. The self-assembly of the microstructures was probed at varying pH. In general, tubular formations were observed at a pH range of 4-6. The formed microtubes were then utilized for fabrication with EA. We probed the ability of the microtubes as drug release vehicles for EA as well as for antibacterial applications. It was found that the release of EA was both pH and concentration dependent. The biocompatibility as well as cytotoxicity of the EA-fabricated microtubes was examined in the presence of mammalian normal rat kidney (NRK) cells. Finally the antibacterial effects of the EA incorporated peptide microtubes was examined against Escherichia coli and Staphylococcus aureus.
authors.affiliation: Department of Chemistry, Fordham University, 441 East Fordham Road, Bronx, NY 10458, United States.
authors.forename: Stacey N
authors.initials: SN
authors.lastname: Barnaby
authors.forename: Karl R
authors.initials: KR
authors.lastname: Fath
authors.forename: Areti
authors.initials: A
authors.lastname: Tsiola
authors.forename: Ipsita A
authors.initials: IA
authors.lastname: Banerjee
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D049109:Cell Proliferation; D004610:Ellagic Acid / Q000737:chemistry / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects*; D006863:Hydrogen-Ion Concentration; D007668:Kidney / Q000166:cytology; D008826:Microbial Sensitivity Tests; D008870:Microtubules / Q000737:chemistry*; D010316:Particle Size; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D013211:Staphylococcus aureus / Q000187:drug effects*; D013499:Surface Properties
chemical_list: D000900:Anti-Bacterial Agents; D001672:Biocompatible Materials; D010455:Peptides; D004610:Ellagic Acid