title: Hypocaloric diet and regular moderate aerobic exercise is an effective strategy to reduce anthropometric parameters and oxidative stress in obese patients.
abstract: BACKGROUND
  Studies show that diet and exercise are important in the treatment of obesity. The aim of this study was to determine whether additional regular moderate aerobic exercise during a treatment with hypocaloric diet has a beneficial effect on oxidative stress and molecular damage in the obese patient.
  
  
  METHODS
  Oxidative stress of 16 normal-weight (NW) and 32 obese 1 (O1) subjects (BMI 30-34.9 kg/m(2)) were established by biomarkers of oxidative stress in plasma. Recombinant human insulin was incubated with blood from NW or O1 subjects, and the molecular damage to the hormone was analyzed. Two groups of treatment, hypocaloric diet (HD) and hypocaloric diet plus regular moderate aerobic exercise (HDMAE), were formed, and their effects in obese subjects were analyzed.
  
  
  RESULTS
  The data showed the presence of oxidative stress in O1 subjects. Molecular damage and polymerization of insulin was observed more frequently in the blood from O1 subjects. The treatment of O1 subjects with HD decreased the anthropometric parameters as well as oxidative stress and molecular damage, which was more effectively prevented by the treatment with HDMAE.
  
  
  CONCLUSIONS
  HD and HDMAE treatments decreased anthropometric parameters, oxidative stress, and molecular damage in O1 subjects.
authors.affiliation: Department of Sport and Informatics, Pablo de Olavide University, Seville, Spain.
authors.forename: Liliana
authors.initials: L
authors.lastname: Gutierrez-Lopez
authors.forename: Jose Ruben
authors.initials: JR
authors.lastname: Garcia-Sanchez
authors.forename: Maria de Jesus
authors.initials: Mde J
authors.lastname: Rincon-Viquez
authors.forename: Eleazar
authors.initials: E
authors.lastname: Lara-Padilla
authors.forename: Martha P
authors.initials: MP
authors.lastname: Sierra-Vargas
authors.forename: Ivonne M
authors.initials: IM
authors.lastname: Olivares-Corichi
mesh_terms: D000328:Adult; D000886:Anthropometry; D015415:Biomarkers / Q000097:blood; D001823:Body Composition; D001835:Body Weight; D031204:Caloric Restriction; D004038:Diet, Reducing; D002149:Energy Intake; D015444:Exercise / Q000502:physiology*; D006801:Humans; D007328:Insulin / Q000097:blood; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000178:diet therapy / Q000628:therapy*; D018384:Oxidative Stress; D058105:Polymerization; D011994:Recombinant Proteins; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D015415:Biomarkers; D007328:Insulin; D011994:Recombinant Proteins