title: [Meningomyelitis associated with infection by human herpes virus 7: report of two cases].
abstract: Human herpesvirus 7 (HHV-7) may cause encephalomyelitis in immune competent adults. We report two patients infected by the virus. A 34-year-old male presenting with paraparesis and a sensitive deficiency located in D6 dermatome. Cerebrospinal fluid had 35 white blood cells per mm³ and 75 mg protein per dl. A PCR-microarray examination was positive for HHV-7. The patient was treated with prednisolone and ganciclovir with full recovery. A 27-year-old male presenting with headache, fever and diarrhea. Cerebrospinal fluid analysis showed 160 cells per mm³ and 75 mg protein per dl. Viral RNA detection was positive for HHV-7. The patient was managed with analgesia and rest and was discharged with the diagnosis of viral meningitis. Our communication supports the notion that HHV-7 may be considered as pathogen factor in humans, even in immune competent ones.
authors.affiliation: Departamento Neurología, Clínica Las Condes, Santiago, Chile. marcelomirandac@gmail.com
authors.forename: Marcelo
authors.initials: M
authors.lastname: Miranda C
authors.forename: Juan Pablo
authors.initials: JP
authors.lastname: Torres T
authors.forename: Carmen
authors.initials: C
authors.lastname: Larrañaga L
authors.forename: Guillermo
authors.initials: G
authors.lastname: Acuña L
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D020803:Encephalitis, Herpes Simplex / Q000134:cerebrospinal fluid / Q000821:virology*; D016199:Herpesvirus 7, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D007121:Immunocompetence; D008297:Male; D046228:Microarray Analysis / Q000379:methods; D016133:Polymerase Chain Reaction; D012367:RNA, Viral / Q000134:cerebrospinal fluid*; D019349:Roseolovirus Infections / Q000134:cerebrospinal fluid
chemical_list: D012367:RNA, Viral