title: Flavonols intake and the risk of coronary heart disease: a meta-analysis of cohort studies.
abstract: OBJECTIVE
  Prospective cohort are inconsistent regarding the association between flavonols intake and the risk of coronary heart disease (CHD). The aim was to perform a meta-analysis to determine whether an association exists between them in observational studies.
  
  
  METHODS
  We searched PUBMED and EMBASE databases for studies conducted from 1966 through January 2012. Data were independently abstracted by 2 investigators using a standardized protocol. Study-specific risk estimates were combined by using a random-effects model.
  
  
  RESULTS
  A total of nine general population cohorts with 216,908 participants and more than 5249 CHD cases were included in the meta-analysis. The summary relative risk (RR) did not indicate a significant association between the highest flavonols intake and reduced risk of CHD (summary RR: 0.91; 95% CI: 0.83, 1.01). Furthermore, no significant association was found through the dose-response analysis (an increment of 20mg/day, summary RR: 0.96; 95% CI: 0.90, 1.03).
  
  
  CONCLUSIONS
  Our results do not support a protective role of flavonols intake against CHD.
authors.affiliation: Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors.forename: Ze-Mu
authors.initials: ZM
authors.lastname: Wang
authors.forename: Zhen-Lin
authors.initials: ZL
authors.lastname: Nie
authors.forename: Bo
authors.initials: B
authors.lastname: Zhou
authors.forename: Xiao-Qing
authors.initials: XQ
authors.lastname: Lian
authors.forename: Huan
authors.initials: H
authors.lastname: Zhao
authors.forename: Wei
authors.initials: W
authors.lastname: Gao
authors.forename: Yong-Sheng
authors.initials: YS
authors.lastname: Wang
authors.forename: En-Zhi
authors.initials: EZ
authors.lastname: Jia
authors.forename: Lian-Sheng
authors.initials: LS
authors.lastname: Wang
authors.forename: Zhi-Jian
authors.initials: ZJ
authors.lastname: Yang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D003327:Coronary Disease / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D044948:Flavonols / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012306:Risk
chemical_list: D044948:Flavonols