title: [Annexins as a new thrombotic factors].
abstract: This review retraces the current state of knowledge on Annexin A2 and A5 functions causing thrombophilia. Thrombophilia is multifactorial inherited hypercoagulable state, promoted by multiple gen-gen and gen-environmental factors. Abnormalities of placenta in intervillous spacies and horion vessels are discussed as venous thrombosis. The cause of adverse pregnancy outcome is still unknown, etiological up to 50% of cases. Understanding of function of sequence variations in potencial risk factors annexins A2 and A5 could precise estimation of individual risk and should guide the adequate prophylaxis among pregnant women.
authors.forename: B
authors.initials: B
authors.lastname: Cherkelova
mesh_terms: D017302:Annexins / Q000378:metabolism*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000378:metabolism*; D011256:Pregnancy Outcome; D013927:Thrombosis / Q000378:metabolism*
chemical_list: D017302:Annexins