title: Seven new secoiridoids with anti-hepatitis B virus activity from Swertia angustifolia.
abstract: Seven new secoiridoids, swertianglide (1) and swertianosides A-F (2-7), together with fifteen known compounds, were isolated from the whole plants of Swertia angustifolia. Their structures were elucidated on the basis of extensive spectroscopic analyses ([α](D), UV, IR, MS, 1D- and 2D-NMR). Fourteen compounds were evaluated for their anti-hepatitis B virus (HBV) activities on the Hep G 2.2.15 cell line in vitro. Compound 2, an unusual secoiridoid glycoside dimer, showed significant activities inhibiting the secretion of HBsAg (IC₅₀ 0.18 mM, SI 3.11) and HBeAg (IC₅₀ 0.12 mM, SI 4.67).
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, PR China.
authors.forename: Kang
authors.initials: K
authors.lastname: He
authors.forename: Yun-Bao
authors.initials: YB
authors.lastname: Ma
authors.forename: Tuan-Wu
authors.initials: TW
authors.lastname: Cao
authors.forename: Hong-Ling
authors.initials: HL
authors.lastname: Wang
authors.forename: Fu-Qiang
authors.initials: FQ
authors.lastname: Jiang
authors.forename: Chang-An
authors.initials: CA
authors.lastname: Geng
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Zhang
authors.forename: Ji-Jun
authors.initials: JJ
authors.lastname: Chen
mesh_terms: D000998:Antiviral Agents / Q000302:isolation & purification*; D056945:Hep G2 Cells; D006515:Hepatitis B virus / Q000187:drug effects*; D006801:Humans; D039823:Iridoids / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D029967:Swertia / Q000737:chemistry*
chemical_list: D000998:Antiviral Agents; D039823:Iridoids; C575031:swertianglide