title: Cleaning up polyketide synthases.
abstract: Complex biosynthetic enzymes such as polyketide synthases make mistakes. In this issue of Chemistry & Biology, Jensen et al. report that a discrete family of acyltransferases is responsible for error correction, hydrolyzing key biosynthetic intermediates from a multi-enzyme complex. This activity might find use in understanding polyketide biosynthesis, particularly in uncultivated organisms and in tailoring the synthesis of small molecules.
authors.affiliation: Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT 84112, USA.
authors.forename: Jason C
authors.initials: JC
authors.lastname: Kwan
authors.forename: Eric W
authors.initials: EW
authors.lastname: Schmidt
mesh_terms: D000217:Acyltransferases / Q000378:metabolism*; D061065:Polyketides / Q000378:metabolism*
chemical_list: D061065:Polyketides; D000217:Acyltransferases