title: [Results of the IOP decrease after application of some mixtures of amino acids and antiglaucomatics in rabbits (a review of experimental publications)].
abstract: OBJECTIVE
  To summarise of experimental results performed on rabbit eyes focused to influence the physiological intraocular pressure (lOP) after application of some amino acids mixture with some regularly used antiglaucomatics.
  
  
  METHODS
  The experiments were performed on adult rabbits (female of the New Zealand White species). The applicated substances were: 10% solution of amino acids (L-lysin.2HCl.2H2O, L-arginine.HCL or L-glycine.HCL) in antiglau-comatics 0.5% timolol (Timoptol) or 0.005% latanoprost (Xalatan). This mixture was applicated to the left eye; right eye was used as control. The measurement of IOP and pupil diameter was performed before instillation, in 15th, 30th, 60th, 180th, 240th minute and 24 hours after application.
  
  
  RESULTS
  Functional bioactivity of the used antiglaucomatics in case of decreased lOP is rising after interaction with the relevant specific amino acid. Glycine in timolol showed the highest effect on average decrease of the lOP physiological values (lOP decrease reached - 5,5 torr) followed by arginine in timolol (lOP decrease reached - 3,3 torr). The lOP decrease after other combinations of amino acids and antiglaucomatics was in average lower or nonsignificant.
  
  
  CONCLUSIONS
  Through interaction between in vitro prepared mixture free amino acids and antiglaucomatics a new, biologically active substance (metabolite) is created. After instillation in experimental condition achieving stronger and longer decrease of the lOP compared with a single antiglaucomatic or amino acid.
authors.affiliation: Klinika oftalmológie LF UK v Bratislave. olah@ru.unb.sk
authors.forename: Z
authors.initials: Z
authors.lastname: Oláh
authors.forename: J
authors.initials: J
authors.lastname: Veselovský
mesh_terms: D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D001120:Arginine / Q000494:pharmacology; D005260:Female; D005998:Glycine / Q000494:pharmacology; D007429:Intraocular Pressure / Q000187:drug effects*; D000077338:Latanoprost; D008239:Lysine / Q000494:pharmacology; D011461:Prostaglandins F, Synthetic / Q000494:pharmacology*; D011817:Rabbits; D013999:Timolol / Q000494:pharmacology*
chemical_list: D000596:Amino Acids; D011461:Prostaglandins F, Synthetic; D000077338:Latanoprost; D013999:Timolol; D001120:Arginine; D008239:Lysine; D005998:Glycine