title: Influence of serum cortisol levels on glycemic control in children with type 1 diabetes.
abstract: The association between plasma glucose (PG), HbA1c and serum cortisol levels in children with type 1 diabetes was investigated to determine the influence of serum cortisol on their glycemic control. A total of 45 children, aged 10-15 years, with type 1 diabetes for at least 3 years of diabetes were studied. Most of them did not have pancreatic beta-cell function. The cortisol levels among all patients were stratified according to fasting plasma glucose levels (50-99, 100-199, 200-299, & > or = 300 mg/dL), and the HbAlc levels (<7.0, 7.0-7.9, 8.0-8.9, & > or = 9%). The mean fasting PG, HbA1c and serum cortisol levels were 174 +/- 97 mg/dL, 7.7 +/- 1.3% and 23.04 +/- 16.6 ug/dl, respectively. The cortisol levels were highly correlated with PG levels (r =0.553, P < 0.0001) and mildly correlated with HbA1c levels (r=0.301, P=0.0192). Patients with high PG levels gave significantly higher cortisol levels as compared to those with lower PG levels (18.4 +/- 7.3, 26.8 +/- 18.3, 31.4 +/- 17.0 & 36.3 +/- 17.2ug/dl, P=0.0009). There were no significant differences in serum cortisol levels among patients stratified according to HbA1c levels (P=0.1566), however, patients with HbA1c levels > or = 9% had significantly higher cortisol levels than those with HbA1c levels<7% (32.6 +/- 14.4 vs. 21.8 +/- 11.3ug/dl, P=0.0291).
authors.affiliation: Department of Pediatric Medicine, Faculty of Medicine, Cairo, University, Cairo, Egypt.
authors.forename: Amira A Abd El-Rahman
authors.initials: AA
authors.lastname: Mosbah
authors.forename: Nahla A Bahgat
authors.initials: NA
authors.lastname: Abd-Ellatif
authors.forename: Ehab Ibrahim
authors.initials: EI
authors.lastname: Sorour
mesh_terms: D000293:Adolescent; D001786:Blood Glucose / Q000502:physiology*; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D006854:Hydrocortisone