title: Genetic association study of individual symptoms in depression.
abstract: The heritability of some individual depressive symptoms has been well established. However, the causal genes related to individual depressive symptoms and genetic effects on the courses of individual depressive symptoms are still unclear. We examined these issues in 241 Korean patients who met the DSM-IV-TR criteria for major depression. Patients entered a 12-week clinical trial with antidepressants. A total of 1399 single-nucleotide polymorphisms (SNPs) of 79 candidate genes were assessed. The rs557762 and the TT haplotype in the 11th haplotype block of the GRIA3 gene were associated with feelings of guilt in females. The GGCCGGGC haplotype in the first haplotype block of TPH1 was significantly associated with middle insomnia. The ACAG haplotype in the 13th haplotype block of the GRIK2 gene was associated with somatic anxiety. Moreover, the effect of the rs557762 on guilt significantly varied across times. Our results indicate that there are associations between particular gene polymorphisms and some individual depressive symptoms. These results could contribute to understanding the biological mechanisms of depression.
authors.affiliation: Department of Psychiatry, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Irwon-dong, Kangnam-gu, Seoul 135-710, Republic of Korea.
authors.forename: Woojae
authors.initials: W
authors.lastname: Myung
authors.forename: Jihye
authors.initials: J
authors.lastname: Song
authors.forename: Shinn-Won
authors.initials: SW
authors.lastname: Lim
authors.forename: Hong-Hee
authors.initials: HH
authors.lastname: Won
authors.forename: Seonwoo
authors.initials: S
authors.lastname: Kim
authors.forename: Yujin
authors.initials: Y
authors.lastname: Lee
authors.forename: Hyo Shin
authors.initials: HS
authors.lastname: Kang
authors.forename: Hong
authors.initials: H
authors.lastname: Lee
authors.forename: Jong-Won
authors.initials: JW
authors.lastname: Kim
authors.forename: Bernard J
authors.initials: BJ
authors.lastname: Carroll
authors.forename: Doh Kwan
authors.initials: DK
authors.lastname: Kim
mesh_terms: D000368:Aged; D000928:Antidepressive Agents / Q000627:therapeutic use; D044466:Asian People / Q000235:genetics / Q000523:psychology; D003865:Major Depressive Disorder / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies / Q000379:methods* / Q000706:statistics & numerical data; D006167:Guilt; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D007206:Individuality; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D018091:Receptors, AMPA / Q000235:genetics*; D018092:Kainic Acid Receptors / Q000235:genetics*; D063189:Symptom Assessment / Q000379:methods / Q000523:psychology; D014365:Tryptophan Hydroxylase / Q000235:genetics*; D000097806:GluK2 Kainate Receptor
chemical_list: D000928:Antidepressive Agents; D018091:Receptors, AMPA; D018092:Kainic Acid Receptors; D014365:Tryptophan Hydroxylase; D000097806:GluK2 Kainate Receptor; C104723:glutamate receptor ionotropic, AMPA 3; C497467:TPH1 protein, human