title: Urinary neutrophil gelatinase-associated lipocalin and L-type fatty acid binding protein as diagnostic markers of early acute kidney injury after liver transplantation.
abstract: OBJECTIVE
  We examined the value of two potential novel urinary biomarkers, neutrophil gelatinase-associated lipocalin (NGAL) and L-type fatty acid binding protein (L-FABP), in diagnosing acute kidney injury (AKI) in liver transplant recipients.
  
  
  METHODS
  NGAL and L-FABP in urinary sample from Twenty-five patients before surgery and at 2, 4, 6, 12, 24, 48, 72 and 120 h after the anhepatic phase were tested. Standard statistics were used along with receiver-operating characteristic (ROC) analysis to evaluate the diagnostic value of selected markers.
  
  
  RESULTS
  Urinary NGAL was only slightly elevated at 2 h in the non-AKI group while rose and stayed high from 2-6 h in the AKI group. However, urinary L-FABP rose transiently in both groups 2-120 h following surgery. The level of urinary NGAL presented differences at 2-6 h (p < 0.05) and urinary L-FABP at 4 h (p < 0.05) between AKI and non-AKI groups. ROC analysis showed that area under the curves (AUCs) of NGAL were 0.766, 0.773, and 0.773 at 2, 4 and 6 h respectively while 0.760 of L-FABP at 4 h.
  
  
  CONCLUSIONS
  Urinary NGAL rather than L-FABP appeared to be a sensitive and specific marker of AKI in liver transplant recipients.
authors.affiliation: Renal Division, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: Li
authors.forename: Mingli
authors.initials: M
authors.lastname: Zhu
authors.forename: Qiang
authors.initials: Q
authors.lastname: Xia
authors.forename: Siyue
authors.initials: S
authors.lastname: Wang
authors.forename: Jiaqi
authors.initials: J
authors.lastname: Qian
authors.forename: Renhua
authors.initials: R
authors.lastname: Lu
authors.forename: Miaolin
authors.initials: M
authors.lastname: Che
authors.forename: Huili
authors.initials: H
authors.lastname: Dai
authors.forename: Qingwei
authors.initials: Q
authors.lastname: Wu
authors.forename: Zhaohui
authors.initials: Z
authors.lastname: Ni
authors.forename: Bengt
authors.initials: B
authors.lastname: Lindholm
authors.forename: Jonas
authors.initials: J
authors.lastname: Axelsson
authors.forename: Yucheng
authors.initials: Y
authors.lastname: Yan
mesh_terms: D058186:Acute Kidney Injury / Q000097:blood / Q000175:diagnosis* / Q000209:etiology / Q000652:urine*; D000209:Acute-Phase Proteins / Q000652:urine*; D000328:Adult; D019540:Area Under Curve; D015415:Biomarkers / Q000652:urine; D003404:Creatinine / Q000097:blood; D058625:End Stage Liver Disease / Q000601:surgery; D050556:Fatty Acid-Binding Proteins / Q000652:urine*; D005260:Female; D006801:Humans; D000071068:Lipocalin-2; D054834:Lipocalins / Q000652:urine*; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011446:Prospective Studies; D011518:Proto-Oncogene Proteins / Q000652:urine*; D012372:ROC Curve
chemical_list: D000209:Acute-Phase Proteins; D015415:Biomarkers; C493319:FABP1 protein, human; D050556:Fatty Acid-Binding Proteins; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D011518:Proto-Oncogene Proteins; D003404:Creatinine