title: Elimination half-life of anti-Müllerian hormone.
abstract: BACKGROUND
  Anti-Müllerian hormone (AMH) is a glycoprotein that is secreted by the granulosa cells in the human ovary. In the postpubertal female, circulating AMH reflects the number of follicles within the ovary. It is mandatory to know the serum elimination half-life (t(1/2)) of AMH to study in vivo short-term changes of the hormone.
  
  
  OBJECTIVE
  Our objective was to determine the kinetics of decay of AMH in the human female.
  
  
  METHODS
  Premenopausal women undergoing total abdominal hysterectomy plus bilateral salpingo-oophorectomy participated in this cohort study (n = 21) at an academic tertiary referral center.
  
  
  METHODS
  Serum samples were obtained immediately before surgery and in 12-h intervals thereafter for 8 d.
  
  
  METHODS
  AMH elimination was calculated, applying a one-compartment model with first-order kinetics.
  
  
  RESULTS
  Mean preoperative AMH levels were 0.67 ng/ml (range, 0.1-1.78 ng/ml) and dropped to 0.08 ng/ml within 84 h after surgery. The AMH decay followed first-order kinetics. The mean terminal t(1/2) of AMH was calculated as 27.6 ± 0.8 h.
  
  
  CONCLUSIONS
  AMH elimination reaches approximately 84% after 3 d, approximately 91% after 4 d, approximately 95% after 5 d, and can be considered complete after 8 d.
authors.affiliation: Department of Reproductive Medicine, University Hospital of Schleswig-Holstein, D-23538 Luebeck, Germany. griesing@uni-luebeck.de
authors.forename: G
authors.initials: G
authors.lastname: Griesinger
authors.forename: K
authors.initials: K
authors.lastname: Dafopoulos
authors.forename: N
authors.initials: N
authors.lastname: Buendgen
authors.forename: I
authors.initials: I
authors.lastname: Cascorbi
authors.forename: P
authors.initials: P
authors.lastname: Georgoulias
authors.forename: A
authors.initials: A
authors.lastname: Zavos
authors.forename: C I
authors.initials: CI
authors.lastname: Messini
authors.forename: I E
authors.initials: IE
authors.lastname: Messinis
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000378:metabolism*; D015331:Cohort Studies; D005260:Female; D006107:Granulosa Cells / Q000378:metabolism*; D006207:Half-Life; D006801:Humans; D007044:Hysterectomy; D007700:Kinetics; D008875:Middle Aged; D010052:Ovariectomy; D011184:Postoperative Period; D057234:Preoperative Period; D012016:Reference Values
chemical_list: D054304:Anti-Mullerian Hormone