title: Oxidative stress and antioxidant enzyme activities in newborns with oesophageal atresia and their mothers.
abstract: OBJECTIVE
  To measure the oxidant/antioxidant status of newborn babies with oesophageal atresia and their mothers, compared with healthy control subjects.
  
  
  METHODS
  This case-control study included 40 participants: 10 newborns with oesophageal atresia and their mothers, and 10  healthy newborns and their mothers. Whole blood malondialdehyde (MDA) levels and the activities of antioxidant enzymes (catalase, carbonic anhydrase [CA], glucose-6-phosphate dehydrogenase [G-6-PD], and superoxide dismutase [SOD]) were measured.
  
  
  RESULTS
  MDA levels and CA activity were significantly  higher, and catalase, SOD and G-6-PD activities were significantly lower, in newborns with oesophageal atresia and their mothers than in healthy newborns and their mothers. Although CA activity was similar between the newborns and mothers in the patient group, it was significantly lower in  newborns than in mothers in the healthy group.
  
  
  CONCLUSIONS
  Increased lipid peroxidation might play an important role in the pathogenesis of oesophageal atresia. Impairment of the free radical/antioxidant balance may lead to increased free radical and decreased antioxidant levels in oesophageal  atresia.
authors.affiliation: Department of Paediatric Surgery, Medical Faculty, University of Yuzuncu Yil, Van, Turkey. mmelek44@yahoo.com
authors.forename: M
authors.initials: M
authors.lastname: Melek
authors.forename: H
authors.initials: H
authors.lastname: Demir
authors.forename: S
authors.initials: S
authors.lastname: Bilici
authors.forename: B
authors.initials: B
authors.lastname: Beger
authors.forename: U
authors.initials: U
authors.lastname: Cobanoğlu
authors.forename: I
authors.initials: I
authors.lastname: Meral
authors.forename: S
authors.initials: S
authors.lastname: Keskin
authors.forename: E
authors.initials: E
authors.lastname: Ozmen
mesh_terms: D000975:Antioxidants / Q000378:metabolism*; D002256:Carbonic Anhydrases / Q000097:blood; D016022:Case-Control Studies; D002374:Catalase / Q000097:blood; D004933:Esophageal Atresia / Q000097:blood / Q000201:enzymology* / Q000473:pathology*; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000097:blood; D006801:Humans; D007231:Infant, Newborn; D008315:Malondialdehyde / Q000097:blood; D009035:Mothers; D018384:Oxidative Stress; D018709:Statistics, Nonparametric; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D000975:Antioxidants; D008315:Malondialdehyde; D005954:Glucosephosphate Dehydrogenase; D002374:Catalase; D013482:Superoxide Dismutase; D002256:Carbonic Anhydrases