title: [Expression of FAPalpha and TGF-beta1 in sudden deaths due to acute myocardial ischemia].
abstract: OBJECTIVE
  To explore the expression of fibroblast activation protein alpha (FAPalpha) and transforming growth factor-beta1 (TGF-beta1) in myocardial cytoplasm for the cases of sudden death due to acute myocardial ischemia.
  
  
  METHODS
  The heart tissues of 47 cases were collected. All cases were divided into three groups: control group, acute myocardial infarction group and recurrent myocardial infarction group. FAPalpha and TGF-beta1 expressions were explored in myocardial cytoplasm by immunohistochemistry technology. The staining results were collected by image analysis system and then the positive area ratio and average optical density were detected. The positive signal differences were compared among the groups.
  
  
  RESULTS
  Strong FAPalpha and TGF-beta1 expressions were detected in myocardial cytoplasm in both acute and recurrent myocardial infarction groups. The expression of FAPalpha was not detected in myocardial cytoplasm in control group and TGF-beta1 expression showed a weak positive result. FAPalpha and TGF-beta1 expressions showed the statistical difference (P < 0.05) in myocardial infarction (acute and recurrent) groups and control group.
  
  
  CONCLUSIONS
  FAPalpha and TGF-beta1 can be the diagnostic markers for determing acute myocardial infarction.
authors.affiliation: Detachment of Criminal Science and Technology, Public Security Bureau of Hulunbuir, Hulunbuir 021008, China. wjyxt@sina.com
authors.forename: Xiang-Tian
authors.initials: XT
authors.lastname: Yuan
authors.forename: Xue
authors.initials: X
authors.lastname: Peng
authors.forename: Zhan-Feng
authors.initials: ZF
authors.lastname: Jin
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001344:Autopsy; D016757:Death, Sudden, Cardiac; D010450:Endopeptidases; D005260:Female; D049429:Forensic Pathology; D018093:Gelatinases / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000378:metabolism / Q000473:pathology; D017202:Myocardial Ischemia / Q000378:metabolism* / Q000473:pathology; D009206:Myocardium / Q000378:metabolism*; D032383:Myocytes, Cardiac / Q000378:metabolism; D012008:Recurrence; D012189:Retrospective Studies; D012697:Serine Endopeptidases / Q000378:metabolism*; D053773:Transforming Growth Factor beta1 / Q000378:metabolism*; D000099167:Fibroblast Activation Protein Alpha
chemical_list: D010450:Endopeptidases; D018093:Gelatinases; D008565:Membrane Proteins; D012697:Serine Endopeptidases; D053773:Transforming Growth Factor beta1; D000099167:Fibroblast Activation Protein Alpha; C508960:TGFB1 protein, human