title: Plasma heme oxygenase-1 concentration in relation to impaired glucose regulation in a non-diabetic Chinese population.
abstract: BACKGROUND
  Our previous study has recently shown that plasma heme oxygenase-1 (HO-1), a stress-responsive protein, is elevated in individuals with type 2 diabetes. The current study aimed to examine the association between plasma HO-1 concentration and impaired glucose regulation (IGR) in non-diabetic individuals.
  
  
  METHODS
  We conducted a case-control study including a total of 865 subjects (262 IGR individuals and 603 healthy controls) in a Chinese population. Basic characteristics were collected by questionnaire and standardized anthropometric measurements. Plasma HO-1 concentration was determined by ELISA.
  
  
  RESULTS
  Plasma HO-1 concentration was significantly increased in IGR individuals compared with healthy controls (1.34 (0.81-2.29) ng/ml vs 0.98 (0.56-1.55) ng/ml, P<0.001). After adjustment for age, sex, and BMI, the ORs for IGR in the highest quartile of plasma HO-1 concentrations, compared with the lowest, was 3.42 (95% CI 2.11-5.54; P for trend <0.001). The trend remained significant even after additional adjustment for smoking, alcohol drinking, hypertension, family history of diabetes, lipid profiles and C-reactive protein. In the receiver-operating characteristic curve analysis, addition of plasma HO-1 concentration to a model with known risk factors yielded significantly improved discriminative value for IGR (area under the curves 0.75 (95% CI 0.71-0.78) vs. 0.72 (95% CI 0.69-0.76); P for difference = 0.026).
  
  
  CONCLUSIONS
  Elevated plasma HO-1 concentration is significantly associated with increased ORs for IGR. However, its clinical utility should be validated in further studies, especially in prospective cohort studies.
authors.affiliation: Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
authors.forename: Wei
authors.initials: W
authors.lastname: Bao
authors.forename: Shuang
authors.initials: S
authors.lastname: Rong
authors.forename: Muxun
authors.initials: M
authors.lastname: Zhang
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Yu
authors.forename: Yanting
authors.initials: Y
authors.lastname: Zhao
authors.forename: Xiao
authors.initials: X
authors.lastname: Xiao
authors.forename: Wei
authors.initials: W
authors.lastname: Yang
authors.forename: Di
authors.initials: D
authors.lastname: Wang
authors.forename: Ping
authors.initials: P
authors.lastname: Yao
authors.forename: Frank B
authors.initials: FB
authors.lastname: Hu
authors.forename: Liegang
authors.initials: L
authors.lastname: Liu
mesh_terms: D019540:Area Under Curve; D044466:Asian People; D002097:C-Reactive Protein / Q000032:analysis; D016022:Case-Control Studies; D004797:Enzyme-Linked Immunosorbent Assay; D018149:Glucose Intolerance / Q000097:blood*; D051547:Heme Oxygenase-1 / Q000097:blood*; D006801:Humans; D016015:Logistic Models; D012372:ROC Curve; D018709:Statistics, Nonparametric
chemical_list: D002097:C-Reactive Protein; D051547:Heme Oxygenase-1