title: Invasive aspergillosis in a putty-nosed monkey (Cercopithecus nictitans) with adrenocortical Cushing's syndrome.
abstract: BACKGROUND
  An 18-year-old captive female putty-nosed-monkey (Cercopithecus nictitans) with a history of long-term infertility and hyperglucocorticism was euthanized because of perforating thoracic trauma induced by group members and subsequent development of neurological signs.
  
  
  METHODS
  Complete necropsy and histopathological examination of formalin-fixed tissue samples was carried out.
  
  
  RESULTS
  The monkey showed invasive pulmonary and cerebral infection with Aspergillus fumigatus together with adrenocortical neoplasia and signs of Cushing's syndrome, such as alopecia with atrophic skin changes, evidence for diabetes mellitus and marked immunosuppression.
  
  
  CONCLUSIONS
  Spontaneous endocrinopathies are rarely described in non-human primates. Here we report the first case of spontaneous adrenocortical hyperglucocorticism predisposing to systemic aspergillosis in a putty-nosed monkey.
authors.affiliation: Veterinary Department, Duisburg Zoo, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Jurczynski
authors.forename: E
authors.initials: E
authors.lastname: Gruber-Dujardin
authors.forename: D
authors.initials: D
authors.lastname: Widmer
authors.forename: F-J
authors.initials: FJ
authors.lastname: Kaup
authors.forename: K
authors.initials: K
authors.lastname: Mätz-Rensing
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology; D002521:Cercopithecus; D005260:Female; D055744:Invasive Pulmonary Aspergillosis / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D008168:Lung / Q000473:pathology; D008992:Monkey Diseases / Q000276:immunology / Q000473:pathology*; D047748:Pituitary ACTH Hypersecretion / Q000150:complications / Q000276:immunology / Q000662:veterinary*