title: A study of magnesium deficiency in human and experimental pulmonary hypertension.
abstract: Pulmonary hypertension (PH) is defined as an increase in mean pulmonary arterial pressure above 25 mmHg. Pulmonary vasoconstriction, cellular proliferation, inflammation, and oxidative stress are involved in the pathophysiology of PH. Since hypomagnesemia was reported to promote endothelial cell dysfunction leading to inflammation and oxidative stress, we investigated the potential involvement of magnesium (Mg) deficiency in experimental and human PH. Our results indicate that Mg deficiency has no impact on hypoxia-induced PH development or severity, and that no reduction in Mg plasma concentration was observed in patients with severe pulmonary arterial hypertension. Thus, hypomagnesemia does not appear to play a role in the pathophysiology of experimental and human pulmonary hypertension.
authors.affiliation: Université Paris-Sud 11, Faculté de Médecine, 94276 Kremlin-Bicêtre, France.
authors.forename: Marie-Camille
authors.initials: MC
authors.lastname: Chaumais
authors.forename: Florence
authors.initials: F
authors.lastname: Lecerf
authors.forename: Soly
authors.initials: S
authors.lastname: Fattal
authors.forename: Laurent
authors.initials: L
authors.lastname: Savale
authors.forename: Sven
authors.initials: S
authors.lastname: Günther
authors.forename: Alice
authors.initials: A
authors.lastname: Huertas
authors.forename: David
authors.initials: D
authors.lastname: Montani
authors.forename: Frederic
authors.initials: F
authors.lastname: Perros
authors.forename: Marc
authors.initials: M
authors.lastname: Humbert
authors.forename: Michèle
authors.initials: M
authors.lastname: German-Fattal
mesh_terms: D000818:Animals; D005260:Female; D006439:Hemodynamics; D006801:Humans; D006976:Hypertension, Pulmonary / Q000097:blood / Q000378:metabolism* / Q000503:physiopathology; D008274:Magnesium / Q000097:blood / Q000378:metabolism; D008275:Magnesium Deficiency / Q000097:blood / Q000378:metabolism* / Q000503:physiopathology; D051379:Mice; D008810:Mice, Inbred C57BL
chemical_list: D008274:Magnesium