title: Innate immunity modulation in virus entry.
abstract: Entry into a cell submits viruses to detection by pattern recognition receptors (PRRs) leading to an early innate anti-viral response. Several viruses evolved strategies to avoid or subvert PRR recognition at the step of virus entry to promote infection. Whereas viruses mostly escape from soluble PRR detection, endocytic/phagocytic PRRs, such as the mannose receptor or DC-SIGN, are commonly used for virus entry. Moreover, virion-incorporated proteins may also offer viruses a way to dampen anti-viral innate immunity upon virus entry, and entering viruses might usurp autophagy to improve their own infectivity.
authors.affiliation: Université de Lyon, France. mathias.faure@inserm.fr
authors.forename: Mathias
authors.initials: M
authors.lastname: Faure
authors.forename: Chantal
authors.initials: C
authors.lastname: Rabourdin-Combe
mesh_terms: D000818:Animals; D006801:Humans; D007113:Immunity, Innate; D051192:Receptors, Pattern Recognition / Q000235:genetics / Q000276:immunology; D011991:Receptors, Virus / Q000235:genetics / Q000276:immunology; D014764:Viral Proteins / Q000235:genetics / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology* / Q000821:virology*; D053586:Virus Internalization; D014780:Viruses / Q000235:genetics / Q000276:immunology
chemical_list: D051192:Receptors, Pattern Recognition; D011991:Receptors, Virus; D014764:Viral Proteins