title: IVUS-based computational modeling and planar biaxial artery material properties for human coronary plaque vulnerability assessment.
abstract: Image-based computational modeling has been introduced for vulnerable atherosclerotic plaques to identify critical mechanical conditions which may be used for better plaque assessment and rupture predictions. In vivo patient-specific coronary plaque models are lagging due to limitations on non-invasive image resolution, flow data, and vessel material properties. A framework is proposed to combine intravascular ultrasound (IVUS) imaging, biaxial mechanical testing and computational modeling with fluid-structure interactions and anisotropic material properties to acquire better and more complete plaque data and make more accurate plaque vulnerability assessment and predictions. Impact of pre-shrink-stretch process, vessel curvature and high blood pressure on stress, strain, flow velocity and flow maximum principal shear stress was investigated.
authors.affiliation: Department of Mathematical Sciences, Worcester Polytechnic Institute, Worcester, MA 01609, USA.
authors.forename: Haofei
authors.initials: H
authors.lastname: Liu
authors.forename: Mingchao
authors.initials: M
authors.lastname: Cai
authors.forename: Chun
authors.initials: C
authors.lastname: Yang
authors.forename: Jie
authors.initials: J
authors.lastname: Zheng
authors.forename: Richard
authors.initials: R
authors.lastname: Bach
authors.forename: Mehmet H
authors.initials: MH
authors.lastname: Kural
authors.forename: Kristen L
authors.initials: KL
authors.lastname: Billiar
authors.forename: David
authors.initials: D
authors.lastname: Muccigrosso
authors.forename: Dongsi
authors.initials: D
authors.lastname: Lu
authors.forename: Dalin
authors.initials: D
authors.lastname: Tang
mesh_terms: D003198:Computer Simulation; D017023:Coronary Angiography / Q000379:methods; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000473:pathology; D003331:Coronary Vessels / Q000000981:diagnostic imaging* / Q000473:pathology*; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D008955:Models, Cardiovascular; D058226:Plaque, Atherosclerotic / Q000000981:diagnostic imaging* / Q000473:pathology*; D033081:Shear Strength; D013314:Stress, Mechanical; D014463:Ultrasonography