title: Cellular composition of the thymus in Wistar rats in experimental intracerebral hemorrhage.
abstract: The time course of changes in cellular composition of the thymus after experimental intracerebral hemorrhage was studied in rats with various prognostic resistance to emotional stress. Increased migration of T lymphocyte precursors to the subcapsular zone, activation of T lymphocyte differentiation in the thymus, reduced number of mitotic cells, destruction and intensive migration of thymocytes from the thymus were observed. The severity of changes in cell composition in all layers of the thymus after experimental intracerebral hemorrhage was different in rats resistant and predisposed to emotional stress. Predisposition to emotional stress and stress before surgical modeling of intracerebral hemorrhage affected the severity of changes in the thymus. It is shown that autoimmune and adaptation mechanisms, which are closely interrelated, play an important role in the pathogenesis of the intracerebral hemorrhage.
authors.affiliation: Department of Histology, Cytology, and Embryology, Moscow State University of Medicine and Dentistry, Ministry of Health and Social Development of Russian Federation, Russia. svetlanapalna@mail.ru
authors.forename: S P
authors.initials: SP
authors.lastname: Sergeeva
authors.forename: L M
authors.initials: LM
authors.lastname: Erofeeva
authors.forename: M R
authors.initials: MR
authors.lastname: Sapin
authors.forename: E V
authors.initials: EV
authors.lastname: Koplik
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002543:Cerebral Hemorrhage / Q000473:pathology*; D008213:Lymphocyte Activation; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013601:T-Lymphocytes / Q000166:cytology; D013950:Thymus Gland / Q000473:pathology*