title: Hormonal therapy for fertility and huge meningioma: a purely random association?
abstract: Sexual hormones have been related to the growth of meningiomas, also due to the almost constant expression of hormonal receptors by tumoral cells. A case of a woman with previous history of multiple treatment for infertility, harboring a huge meningioma is here described. The tumor was surgically resected and the immunohistochemical examination revealed a high expression of progesterone receptors on tumoral cells surface. A putative role of past progesterone administration in the growth of meningioma has been hypothesized. Particular caution should be paid whenever adopting sexual hormonal therapy, especially for fertility. A radiological examination (ideally MRI) could be advised before starting therapy, in order to rule out any intracranial meningioma.
authors.affiliation: Institute of Neurosurgery, Catholic University School of Medicine, Largo Agostino Gemelli, 800168 Rome, Italy.
authors.forename: Paolo
authors.initials: P
authors.lastname: Frassanito
authors.forename: Pasquale
authors.initials: P
authors.lastname: De Bonis
authors.forename: Pier Paolo
authors.initials: PP
authors.lastname: Mattogno
authors.forename: Mariangela
authors.initials: M
authors.lastname: Novello
authors.forename: Carmelo
authors.initials: C
authors.lastname: Anile
mesh_terms: D000328:Adult; D005260:Female; D006728:Hormones / Q000009:adverse effects*; D006801:Humans; D007246:Infertility / Q000188:drug therapy; D008279:Magnetic Resonance Imaging; D008577:Meningeal Neoplasms / Q000139:chemically induced*; D008579:Meningioma / Q000139:chemically induced*
chemical_list: D006728:Hormones