title: Effect of rosuvastatin on obesity-induced cardiac oxidative stress in Wistar rats--a preliminary study.
abstract: The prevalence of obesity has been rising alarmingly and it has now become a global concern causing an enormous economic burden on the health care system. Obesity is generally linked to complications in lipid metabolism and oxidative stress. The aim of the present study was to investigate the effect of rosuvastatin (10 mg/kg, po) on obesity-induced oxidative stress in high fat-fed Wistar rats. Oral administration of rosuvastatin (10 mg/kg) for 21 days along with high fat diet brought about significant elevation in serum high density lipoprotein and cardiac antioxidant enzymes levels (superoxide dismutase, catalase, glutathione, glutathione peroxidase, glutathione peroxidase-, glutathione reductase- and glutathione-S-transferase) while decreasing in serum lactate dehydrogenase, apolipoprotein-B, lipids (triglycerides, total cholesterol, low density lipoprotein-cholesterol, very low density lipoprotein-cholesterol and atherogenic index) and cardiac thiobarbituric acid reactive substances levels. The results were comparable with orlistat, a standard antiobesity drug. These preliminary results for the first time demonstrate that administration of rosuvastatin can be beneficial for the suppression of obesity-induced oxidative stress and dyslipidemia in high fat-fed Wistar rats.
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, Hamdard University, New Delhi 110 062, India.
authors.forename: Javed A
authors.initials: JA
authors.lastname: Ansari
authors.forename: Uma
authors.initials: U
authors.lastname: Bhandari
authors.forename: K K
authors.initials: KK
authors.lastname: Pillai
authors.forename: S E
authors.initials: SE
authors.lastname: Haque
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D059305:Diet, High-Fat; D005260:Female; D005464:Fluorobenzenes / Q000494:pharmacology*; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology*; D009206:Myocardium / Q000378:metabolism; D009765:Obesity / Q000150:complications* / Q000503:physiopathology; D018384:Oxidative Stress / Q000187:drug effects*; D011743:Pyrimidines / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D000068718:Rosuvastatin Calcium; D013449:Sulfonamides / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D005464:Fluorobenzenes; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D011743:Pyrimidines; D013449:Sulfonamides; D000068718:Rosuvastatin Calcium