title: Changing clinico-laboratory profile of encephalitis patients in the eastern Uttar Pradesh region of India.
abstract: A cross-sectional study was done on 100 consecutive paediatric patients presenting with acute encephalitis syndrome. The clinico-laboratory features of all patients were recorded in a prestructured performa. Cerebrospinal fluid and serum samples were tested for: Japanese encephalitis (JE) virus; Chandipura virus; coxsackie virus; dengue virus; enterovirus 76; and West Nile virus. Twenty-two (22.0%) patients were confirmed JE cases and 17% had parasitic or bacteriological aetiology. The remaining 61 cases (61.0%) in which no viral aetiological agent was found were grouped as non-JE cases. Peripheral vascular failure, splenomegaly and hypotonia were distinguishing clinical features found in the non-JE patients. A high mortality of 26.5% was seen in patients with confirmed or presumptive viral encephalitis (22/83). A fatal outcome was independently associated with peripheral vascular failure and pallor at the time of admission. Early recognition of these signs may help clinicians to manage these cases.
authors.affiliation: PGIMER, Dr RML Hospital, New Delhi, India. drgcbhatt@gmail.com
authors.forename: Girish Chandra
authors.initials: GC
authors.lastname: Bhatt
authors.forename: V P
authors.initials: VP
authors.lastname: Bondre
authors.forename: G N
authors.initials: GN
authors.lastname: Sapkal
authors.forename: Tanya
authors.initials: T
authors.lastname: Sharma
authors.forename: Santosh
authors.initials: S
authors.lastname: Kumar
authors.forename: M M
authors.initials: MM
authors.lastname: Gore
authors.forename: K P
authors.initials: KP
authors.lastname: Kushwaha
authors.forename: A K
authors.initials: AK
authors.lastname: Rathi
mesh_terms: D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood; D002555:Cerebrospinal Fluid / Q000821:virology; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D004664:Encephalitis Virus, Japanese / Q000276:immunology / Q000302:isolation & purification; D004672:Encephalitis, Japanese / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology / Q000821:virology; D018792:Encephalitis, Viral / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology / Q000821:virology; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D007194:India / Q000453:epidemiology; D007223:Infant; D007677:Kidney Function Tests; D008111:Liver Function Tests; D008297:Male; D012640:Seizures / Q000209:etiology
chemical_list: D000914:Antibodies, Viral; D007075:Immunoglobulin M