title: Synthesis and biological evaluation of (3'S)-3'-deoxy-3'-fluoro-3'-C-ethynylcytidine.
abstract: The novel pyrimidine nucleoside, (3'S)-3'-deoxy-3'-fluoro-3'-C-ethynylcytidine (1) was synthesized from cytidine in seven steps. The key step in the synthesis was the introduction of the tertiary fluorine at the 3'-position. Compound 1 was evaluated in vitro against several RNA viruses.
authors.affiliation: Cejera, LLC, Birmingham, Alabama, USA. 01j.clark@gmail.com
authors.forename: Jeremy L
authors.initials: JL
authors.lastname: Clark
authors.forename: Carey B
authors.initials: CB
authors.lastname: Clark
authors.forename: J Christian
authors.initials: JC
authors.lastname: Mason
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D003841:Deoxycytidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D008826:Microbial Sensitivity Tests; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D012328:RNA Viruses / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D011741:Pyrimidine Nucleosides; D003841:Deoxycytidine