title: Antibiotic resistance pattern of uropathogenic Escherichia coli in South West Nigeria.
abstract: BACKGROUND
  Various studies have indicated Escherichia coli to be the most prevalent pathogen isolated in urine specimens.
  
  
  OBJECTIVE
  This study was therefore conducted to find out whether the same holds in this environment. The study will also determine the resistance pattern of uropathogenic Escherichia coli isolates to available antibiotics.
  
  
  METHODS
  Two hundred consecutive urine samples collected from patients with clinical diagnosis of urinary tract infections (UTI) and which have significant bacteriuria were included in this study. These were analysed using standard bacteriological techniques. Escherichia coli isolated from the urine specimens were subjected to antibiotic susceptibility testing because many cases of resistance to commonly available antibiotics here have been encountered in the course of management of patients with UTI.
  
  
  RESULTS
  Klebsiella species (40%) were found to be the most prevalent uropathogen in this environment, followed by E. coli (25%), Staphylococcus aureus (25%), Proteus species (4%), Pseudomonas aeruginosa (2.5%), and Enterococcus faecalis (3.5%). Resistance of E. coli to antibiotics commonly used in our environment for UTI, namely, amoxicillin/ clavulanate, cotrimoxazole and amoxicillin were 100% each. Resistance rates to other antibiotics such as ofloxacin, gentamycin, nalidixic acid and tetracycline were 70%, 92%, 96% and 88% respectively.
  
  
  CONCLUSIONS
  The high antibiotic resistance rates recorded in this study therefore calls for urgent review of existing and implementation of effective antibiotic policy in this community.
authors.affiliation: Department of Medical Microbiology and Parasitology, College of Medicine, University of Ibadan, University College Hospital, Ibadan, Nigeria. abiolaokesola@yahoo.com
authors.forename: A O
authors.initials: AO
authors.lastname: Okesola
authors.forename: T I
authors.initials: TI
authors.lastname: Aroundegbe
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D004927:Escherichia coli Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D006784:Hospitals, Teaching; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009549:Nigeria / Q000453:epidemiology; D015995:Prevalence; D017678:Sex Distribution; D014552:Urinary Tract Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000382:microbiology; D056689:Uropathogenic Escherichia coli / Q000187:drug effects* / Q000302:isolation & purification; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents