title: Changes in blood oxidative and antioxidant parameters in a group of Chinese patients with age-related macular degeneration.
abstract: OBJECTIVE
  To measure the oxidative and antioxidant biochemical parameters in the serum of Chinese patients with age-related macular degeneration (AMD) and in a similar age control group from the same area.
  
  
  METHODS
  A case-control study.
  
  
  METHODS
  56 AMD patients ( 21 early dry, 13 geographic atrophy and 22 wet form) and 34 normal subjects, similar for age and sex were studied.
  
  
  METHODS
  Both groups completed a questionnaire about demographic characters and dieatry habit, and the levels of serum lipid peroxidation (malondialdehyde, MDA) and antioxidants parameters (vitamin C and E, the activities of superoxide dismutase--SOD, total antioxidant capacity--TAC ) were determined.
  
  
  RESULTS
  There was a significantly higher frequency of daily intake of fruit and legumes in controls than in AMD patients. There was a significantly increased serum MDA levels and SOD activities, and significantly decreased serum vitamin C and total antioxidant capacity in AMD patients as compared to controls. The intensity of lipid peroxidation was higher with the progression of AMD. There was not difference in serum vitamin E levels between AMD patients and controls.
  
  
  CONCLUSIONS
  Oxido-reduction disturbance may be involved in the pathogenesis of AMD. There is a significantly decreased antioxidant capacity in AMD patients.
authors.affiliation: Department of Neurology, The First Affiliated Hospital, China Medical University, Shenyang 110001, China. sxl630101@126.com
authors.forename: X L
authors.initials: XL
authors.lastname: Shen
authors.forename: J H
authors.initials: JH
authors.lastname: Jia
authors.forename: P
authors.initials: P
authors.lastname: Zhao
authors.forename: R
authors.initials: R
authors.lastname: Fan
authors.forename: X Y
authors.initials: XY
authors.lastname: Pan
authors.forename: H M
authors.initials: HM
authors.lastname: Yang
authors.forename: L
authors.initials: L
authors.lastname: Liu
mesh_terms: D000975:Antioxidants / Q000008:administration & dosage* / Q000378:metabolism*; D001205:Ascorbic Acid / Q000378:metabolism; D044466:Asian People; D015415:Biomarkers / Q000097:blood; D001774:Blood Chemical Analysis; D016022:Case-Control Studies; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008268:Macular Degeneration / Q000097:blood* / Q000201:enzymology; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D008875:Middle Aged; D010084:Oxidation-Reduction; D013482:Superoxide Dismutase / Q000378:metabolism*; D014810:Vitamin E / Q000378:metabolism
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D014810:Vitamin E; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D001205:Ascorbic Acid