title: Association of sterol regulatory element-binding transcription factor gene polymorphisms with ischaemic stroke.
abstract: OBJECTIVE
  To explore the association between polymorphisms of the sterol regulatory element-binding transcription factor (SREBF) gene and ischaemic stroke.
  
  
  METHODS
  The SREBF1c 54G>C and SREBPF2 1784G>C genotypes were assessed using restriction fragment length  polymorphism analysis in 446 Han Chinese ischaemic stroke patients and 355 Han Chinese control subjects without cerebrovascular disease.
  
  
  RESULTS
  The frequencies of the SREBF2 1784G>C CC genotype and the C allele were significantly higher in the ischaemic stroke group than in controls.  Patients with ischaemic stroke who had the SREBF2 1784G>C CC genotype had significantly lower high-density lipoprotein (HDL) levels, compared with ischaemic stroke patients and control subjects with the GC or GG genotypes. Multivariate logistic regression analysis revealed a significant  positive association between SREBF2 1784G>C and ischaemic stroke; an inverse association was observed between HDL level and risk of ischaemic stroke.
  
  
  CONCLUSIONS
  The CC genotype of the SREBF2 1784G>C polymorphism was associated with an increased risk of ischaemic stroke,  possibly through decreasing the HDL level, which was inversely associated with the risk of ischaemic stroke.
authors.affiliation: Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.
authors.forename: X
authors.initials: X
authors.lastname: Jin
authors.forename: F
authors.initials: F
authors.lastname: Zeng
authors.forename: N
authors.initials: N
authors.lastname: Zhang
authors.forename: T
authors.initials: T
authors.lastname: Huang
authors.forename: Q
authors.initials: Q
authors.lastname: Meng
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
mesh_terms: D044466:Asian People / Q000235:genetics; D002545:Brain Ischemia / Q000150:complications / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005006:Ethnicity / Q000235:genetics; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D051780:Sterol Regulatory Element Binding Protein 1 / Q000235:genetics*; D051782:Sterol Regulatory Element Binding Protein 2 / Q000235:genetics*; D020521:Stroke / Q000150:complications / Q000235:genetics*
chemical_list: C497387:SREBF1 protein, human; C497390:SREBF2 protein, human; D051780:Sterol Regulatory Element Binding Protein 1; D051782:Sterol Regulatory Element Binding Protein 2