title: Targeting epigenetic misregulation in synovial sarcoma.
abstract: Like many sarcomas, synovial sarcoma is driven by a characteristic oncogenic transcription factor fusion, SS18-SSX. In this issue of Cancer Cell, Su et al. elucidate the protein partners necessary for target gene misregulation and demonstrate a direct effect of histone deacetylase inhibitors on the SS18-SSX complex composition, expression misregulation, and apoptosis.
authors.affiliation: Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD 20892, USA.
authors.forename: Joshua J
authors.initials: JJ
authors.lastname: Waterfall
authors.forename: Paul S
authors.initials: PS
authors.lastname: Meltzer