title: Coercing bisphosphonates to kill cancer cells with nanoscale coordination polymers.
abstract: Nanoscale coordination polymers containing exceptionally high loadings of bisphosphonates were coated with single lipid bilayers to control the drug release kinetics and functionalized with a targeting ligand to endow cell-targeting capability, leading to much enhanced cytotoxicity against human lung and pancreatic cancer cells.
authors.affiliation: Department of Chemistry, CB#3290, University of North Carolina, Chapel Hill, North Carolina 27599, USA.
authors.forename: Demin
authors.initials: D
authors.lastname: Liu
authors.forename: Stephanie A
authors.initials: SA
authors.lastname: Kramer
authors.forename: Rachel C
authors.initials: RC
authors.lastname: Huxford-Phillips
authors.forename: Shunzhi
authors.initials: S
authors.lastname: Wang
authors.forename: Joseph
authors.initials: J
authors.lastname: Della Rocca
authors.forename: Wenbin
authors.initials: W
authors.lastname: Lin
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology; D002118:Calcium / Q000737:chemistry; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004164:Diphosphonates / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D007093:Imidazoles / Q000737:chemistry / Q000494:pharmacology; D008051:Lipid Bilayers / Q000378:metabolism; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D000077268:Pamidronate; D011108:Polymers / Q000737:chemistry*; D000077211:Zoledronic Acid
chemical_list: D000970:Antineoplastic Agents; D004164:Diphosphonates; D007093:Imidazoles; D008051:Lipid Bilayers; D011108:Polymers; D000077211:Zoledronic Acid; D000077268:Pamidronate; D002118:Calcium