title: The studies of phase equilibria and efficiency assessment for self-emulsifying lipid-based formulations.
abstract: The study was designed to build up a database for the evaluation of the self-emulsifying lipid formulations performance. A standard assessment method was constructed to evaluate the self-emulsifying efficiency of the formulations based on five parameters including excipients miscibility, spontaneity, dispersibility, homogeneity, and physical appearance. Equilibrium phase studies were conducted to investigate the phase changes of the anhydrous formulation in response to aqueous dilution. Droplet size studies were carried out to assess the influence of lipid and surfactant portions on the resulted droplet size upon aqueous dilution. Formulations containing mixed glycerides showed enhanced self-emulsification with both lipophilic and hydrophilic surfactants. Increasing the polarity of the lipid portion in the formulation leaded to progressive water solubilization capacity. In addition, formulations containing medium chain mixed glycerides and hydrophilic surfactants showed lower droplet size compared with their long chain and lipophilic counterparts. The inclusion of mixed glycerides in the lipid formulations enormously enhances the formulation efficiency.
authors.affiliation: Kayyali Chair for Pharmaceutical Industries, Department of Pharmaceutics, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh, 11451, Kingdom of Saudi Arabia.
authors.forename: Ahmad Abdul-Wahhab
authors.initials: AA
authors.lastname: Shahba
authors.forename: Kazi
authors.initials: K
authors.lastname: Mohsin
authors.forename: Fars Kaed
authors.initials: FK
authors.lastname: Alanazi
mesh_terms: D002626:Chemistry, Pharmaceutical; D004655:Emulsions; D005079:Excipients / Q000737:chemistry*; D005990:Glycerol / Q000031:analogs & derivatives / Q000737:chemistry; D057927:Hydrophobic and Hydrophilic Interactions; D008055:Lipids / Q000737:chemistry*; D019301:Oleic Acid / Q000737:chemistry; D010316:Particle Size; D044367:Phase Transition; D012995:Solubility; D012997:Solvents / Q000737:chemistry; D013501:Surface-Active Agents / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods; D014280:Triglycerides / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: D004655:Emulsions; D005079:Excipients; D008055:Lipids; D012997:Solvents; D013501:Surface-Active Agents; D014280:Triglycerides; C433530:miglyol 810; D014867:Water; D019301:Oleic Acid; C000515:cremophor EL; D005990:Glycerol