title: Highly efficient synthesis and antitumor activity of monosaccharide saponins mimicking components of Chinese folk medicine Cordyceps sinensis.
abstract: Ergosterol 3-O-β-D-glucopyranoside (1a) and ergosterol 3-O-β-D-galactopyranoside (1b) were highly efficiently synthesized and evaluated for their inhibitory activities against two tumor cell lines. The structures of these compounds were extensively confirmed by (1)H, (13)C NMR, IR, and HRMS. Compounds 1a and 1b exhibited interesting cytotoxic profiles. The antitumor activity of compound 1a was higher than that of 1b.
authors.affiliation: Key Laboratory of Food Nutrition and Safety, Ministry of Education, College of Food Science and Biotechnology, Tianjin University of Science and Technology, Tianjin, 300457, China. zhyuanzhu@tust.edu.cn
authors.forename: Zhen-Yuan
authors.initials: ZY
authors.lastname: Zhu
authors.forename: Qiang
authors.initials: Q
authors.lastname: Yao
authors.forename: Yang
authors.initials: Y
authors.lastname: Liu
authors.forename: Chuan-Ling
authors.initials: CL
authors.lastname: Si
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.forename: Nian
authors.initials: N
authors.lastname: Liu
authors.forename: Hong-Yu
authors.initials: HY
authors.lastname: Lian
authors.forename: Li-Na
authors.initials: LN
authors.lastname: Ding
authors.forename: Yong-Min
authors.initials: YM
authors.lastname: Zhang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D032661:Cordyceps / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D004875:Ergosterol / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005697:Galactosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005960:Glucosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008516:Medicine, Chinese Traditional; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D012503:Saponins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005697:Galactosides; D005960:Glucosides; D012503:Saponins; C573198:ergosterol 3-O-beta-D-galactopyranoside; C573199:ergosterol 3-O-beta-D-glucopyranoside; D004875:Ergosterol