title: Antinuclear antibodies predicts a poor IVF-ET outcome: impaired egg and embryo development and reduced pregnancy rate.
abstract: To investigate the impact of anti-nuclear antibodies (ANAs) on the outcome of in vitro fertilization-embryo transfer (IVF-ET), 66 (96 cycles) infertile women positive for anti-nuclear antibodies (ANA+ group), and 233(285 cycles) infertile women negative for ANAs (ANA- group) were enrolled. The clinical characteristics and IVF outcome were compared between the two groups. In the ANA+ group, the proportion of MII oocytes and two-pronuclear zygotes (2PN), cleavage rate, number of available embryos and proportion of available embryos, number of high-quality embryos and proportion of high-quality embryos were significantly lower than those in the ANA- group. In addition, the pregnancy rate and implantation rate in patients positive for ANA was markedly lower than the ANA- patients (28.1% vs 46.4%, 15% vs 25.7%, respectively). Thus, our findings suggest that the presence of ANAs significantly interfere with the oocyte and embryo development, as well as reduce implantation and pregnancy rate in patients undergoing IVF treatment.
authors.affiliation: Reproductive Medicine Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China.
authors.forename: Ying
authors.initials: Y
authors.lastname: Ying
authors.forename: Yi-ping
authors.initials: YP
authors.lastname: Zhong
authors.forename: Can-quan
authors.initials: CQ
authors.lastname: Zhou
authors.forename: Yan-wen
authors.initials: YW
authors.lastname: Xu
authors.forename: Qiong
authors.initials: Q
authors.lastname: Wang
authors.forename: Jie
authors.initials: J
authors.lastname: Li
authors.forename: Xiao-ting
authors.initials: XT
authors.lastname: Shen
authors.forename: Hai-tao
authors.initials: HT
authors.lastname: Wu
mesh_terms: D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood*; D004624:Embryo Transfer; D047108:Embryonic Development; D005260:Female; D005307:Fertilization in Vitro; D012739:Gonadal Steroid Hormones / Q000097:blood; D006801:Humans; D007247:Infertility, Female / Q000097:blood / Q000276:immunology*; D008875:Middle Aged; D009865:Oocytes / Q000254:growth & development; D011247:Pregnancy; D011256:Pregnancy Outcome; D018873:Pregnancy Rate; D055815:Young Adult
chemical_list: D000974:Antibodies, Antinuclear; D012739:Gonadal Steroid Hormones