title: Local delivery of small and large biomolecules in craniomaxillofacial bone.
abstract: Current state of the art reconstruction of bony defects in the craniomaxillofacial (CMF) area involves transplantation of autogenous or allogenous bone grafts. However, the inherent drawbacks of this approach strongly urge clinicians and researchers to explore alternative treatment options. Currently, a wide interest exists in local delivery of biomolecules from synthetic biomaterials for CMF bone regeneration, in which small biomolecules are rapidly emerging in recent years as an interesting adjunct for upgrading the clinical treatment of CMF bone regeneration under compromised healing conditions. This review highlights recent advances in the local delivery small and large biomolecules for the clinical treatment of CMF bone defects. Further, it provides a perspective on the efficacy of biomolecule delivery in CMF bone regeneration by reviewing presently available reports of pre-clinical studies using various animal models.
authors.affiliation: Department of Biomaterials, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
authors.forename: Wei
authors.initials: W
authors.lastname: Ji
authors.forename: Huanan
authors.initials: H
authors.lastname: Wang
authors.forename: Jeroen J J P
authors.initials: JJ
authors.lastname: van den Beucken
authors.forename: Fang
authors.initials: F
authors.lastname: Yang
authors.forename: X Frank
authors.initials: XF
authors.lastname: Walboomers
authors.forename: Sander
authors.initials: S
authors.lastname: Leeuwenburgh
authors.forename: John A
authors.initials: JA
authors.lastname: Jansen
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D001847:Bone Diseases / Q000473:pathology / Q000601:surgery; D001861:Bone Regeneration; D016025:Bone Transplantation / Q000379:methods*; D004195:Disease Models, Animal; D016503:Drug Delivery Systems; D005147:Facial Bones / Q000473:pathology / Q000601:surgery*; D006801:Humans
chemical_list: D001672:Biocompatible Materials