title: Spartium junceum aromatic water: chemical composition and antitumor activity.
abstract: The purpose of this study was to analyse the chemical composition of Spartium junceum L. (also known as Spanish Broom) aromatic water and to evaluate its cytotoxic activity against a series of human cancer cell lines (melanoma: RPMI 7932; leukemia: K562; breast cancer cell: MCF7-Bart and MCF7-ICLC, colon adenocarcinoma: SW480). The results show that the aromatic water was cytotoxic toward the tumor cell lines analyzed (RPMI 7932, K562, MCF7-Bart, MCF7-ICLC, SW480), while it did not appreciably alter the viability of normal keratinocytes (NCTC 2544) suggesting its potential use as an antitumor agent for cancer treatment and/or prevention.
authors.affiliation: Department of Pharmaceutical Sciences, Via San Donato 19/2, Bologna University, 40127 Bologna, Italy. teresa.cerchiara2@unibo.it
authors.forename: Teresa
authors.initials: T
authors.lastname: Cerchiara
authors.forename: Serafina V
authors.initials: SV
authors.lastname: Straface
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Chidichimo
authors.forename: Emilia L
authors.initials: EL
authors.lastname: Belsito
authors.forename: Angelo
authors.initials: A
authors.lastname: Liguori
authors.forename: Barbara
authors.initials: B
authors.lastname: Luppi
authors.forename: Federica
authors.initials: F
authors.lastname: Bigucci
authors.forename: Vittorio
authors.initials: V
authors.lastname: Zecchi
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D045744:Cell Line, Tumor; D004305:Dose-Response Relationship, Drug; D035264:Flowers; D006801:Humans; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D031302:Spartium / Q000737:chemistry*; D014867:Water
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D014867:Water