title: Analysis of fetal biometric measurements in the last 30 years.
abstract: OBJECTIVE
  To compare fetal biometric measurements with standard growth charts for ultrasound parameters existing from the last 30 years.
  
  
  METHODS
  A preliminary prospective study.
  
  
  METHODS
  Artemisia Mean Centre of Perinatal Diagnosis, Rome,Italy.
  
  
  METHODS
  A cross sectional study involving 1000 pregnant women with uncomplicated singleton pregnancy between 14(th) and 41(th) weeks of gestation from 1 January to 30 June 2008. All recruited pregnant women enrolled had an abdominal ultrasonography for fetal biometry. For each measurement, regression models were fitted to estimate the mean and SD. The results were compared with existing references from the last 30 years using Student's T distribution. Moreover, neonatal weights were obtained from 1977 to 2008 by ISTAT.
  
  
  RESULTS
  One thousand normal fetuses from pregnant women, between 22(th) and 23(th) weeks, between 32(th) and 33(th) weeks and at 38(th) week, were thoroughly measured. THERE WERE SIGNIFICANT DIFFERENCES FROM THE COMPARISON WITH OUR DATA FOR EACH GESTATIONAL AGE: femur length and homer length, abdominal circumference, head circumference and occipitofrontal diameter were longer than all parameters of existing references from the last 30 years. The analysis of neonatal weights on ISTAT data from 1977 to 2007 demonstrated a significant increment through the years.
  
  
  CONCLUSIONS
  Fetus is grown up across the years. It is necessary to modify the standard growth charts for ultrasound parameters existing from the last 30 years with actually fetal biometric measurements. It is helpful for a correct clinical approach and for an appropriate management mother-fetus.
authors.affiliation: Department of Obstetrics, Marche Polytechnic University, Ancona, Italy.
authors.forename: Giorgia
authors.initials: G
authors.lastname: Buscicchio
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Milite
authors.forename: Laura
authors.initials: L
authors.lastname: D'Emidio
authors.forename: Maurizio
authors.initials: M
authors.lastname: Giorlandino
authors.forename: Alessandro
authors.initials: A
authors.lastname: Cavaliere
authors.forename: Francesco
authors.initials: F
authors.lastname: Padula
authors.forename: Andrea Luigi
authors.initials: AL
authors.lastname: Tranquilli
authors.forename: Claudio
authors.initials: C
authors.lastname: Giorlandino