title: Atherogenic indices and prehypertension in obese and non-obese children.
abstract: We evaluate the relationship between different lipoproteins and atherogenic indices with pre-hypertension in 297 obese and 942 non-obese children with Tanner stage 1 enrolled in a multicentre, community-based cross-sectional study. Height, weight, fasting glucose and insulin levels, total cholesterol, triglycerides, high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), non-HDL-c, LDL/HDL-c, triglycerides/cholesterol and total cholesterol/HDL-c ratios were measured. Mean age was 8.4 ± 1.2 years; pre-hypertension was identified in 104 (8.4%) participants, 46 (15.5%) obese and 58 (6.1%) non-obese children. The pre-hypertensive non-obese children show a high proportion of family history of hypertension (41.6 and 24.7%, p = 0.002) and elevation of insulin at a relatively low body mass index. The triglycerides:HDL-c ratio, but not other lipoproteins or atherogenic indices, was associated with pre-hypertension in obese (1.15, 95% confidence intervals 1.06-1.26) and non-obese children (1.38 95% confidence intervals 1.22-1.57). The triglycerides:HDL-c ratio is related to pre-hypertension in children; the family history of hypertension seems to be a risk factor in developing pre-hypertension.
authors.affiliation: Biomedical Research Unit, Mexican Social Security Institute, Predio Canoas 100, Siqueiros 225 esq./Castañeda, Col. Silvestre Dorador, 34067 Durango, Mexico.
authors.forename: Martha
authors.initials: M
authors.lastname: Rodríguez-Morán
authors.forename: Fernando
authors.initials: F
authors.lastname: Guerrero-Romero
authors.forename: Celia
authors.initials: C
authors.lastname: Aradillas-García
authors.forename: Carmen
authors.initials: C
authors.lastname: Bermudez-Peña
authors.forename: Luis E
authors.initials: LE
authors.lastname: Simental-Mendia
authors.forename: Juan M
authors.initials: JM
authors.lastname: Vargas Morales
authors.forename: María L
authors.initials: ML
authors.lastname: Torres Rodríguez
authors.forename: Esperanza
authors.initials: E
authors.lastname: de la Cruz Mendoza
mesh_terms: D015992:Body Mass Index; D002648:Child; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003430:Cross-Sectional Studies; D050171:Dyslipidemias / Q000097:blood / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D008800:Mexico / Q000453:epidemiology; D009765:Obesity / Q000097:blood / Q000453:epidemiology*; D058246:Prehypertension / Q000097:blood / Q000453:epidemiology*; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D007328:Insulin; D014280:Triglycerides