title: Effects of dopamine on sensitivity to social bias in Parkinson's disease.
abstract: Patients with Parkinson's disease (PD) sometimes develop impulsive compulsive behaviours (ICBs) due to their dopaminergic medication. We compared 26 impulsive and 27 non-impulsive patients with PD, both on and off medication, on a task that examined emotion bias in decision making. No group differences were detected, but patients on medication were less biased by emotions than patients off medication and the strongest effects were seen in patients with ICBs. PD patients with ICBs on medication also showed more learning from negative feedback and less from positive feedback, whereas off medication they showed the opposite effect.
authors.affiliation: Department of Molecular Neuroscience and Reta Lila Weston Institute for Neurological Studies, University College London, London, United Kingdom.
authors.forename: Atbin
authors.initials: A
authors.lastname: Djamshidian
authors.forename: Sean S
authors.initials: SS
authors.lastname: O'Sullivan
authors.forename: Andrew
authors.initials: A
authors.lastname: Lees
authors.forename: Bruno B
authors.initials: BB
authors.lastname: Averbeck
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D003192:Compulsive Behavior / Q000139:chemically induced* / Q000523:psychology*; D003657:Decision Making / Q000187:drug effects; D004298:Dopamine / Q000009:adverse effects* / Q000627:therapeutic use; D004644:Emotions / Q000187:drug effects*; D005145:Face; D005260:Female; D006801:Humans; D008131:London; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy* / Q000523:psychology; D010775:Photic Stimulation; D021641:Recognition, Psychology / Q000187:drug effects
chemical_list: D004298:Dopamine