title: Regulation of G protein-coupled receptors by palmitoylation and cholesterol.
abstract: Due to their membrane location, G protein-coupled receptors (GPCRs) are subject to regulation by soluble and integral membrane proteins as well as membrane components, including lipids and sterols. GPCRs also undergo a variety of post-translational modifications, including palmitoylation. A recent article by Zheng et al. in BMC Cell Biology demonstrates cooperative roles for receptor palmitoylation and cholesterol binding in GPCR dimerization and G protein coupling, underlining the complex regulation of these receptors.
authors.affiliation: Biomembrane Structure Unit, Department of Biochemistry, University of Oxford, South Parks Rd, Oxford, OX1 3QU, UK.
authors.forename: Alan D
authors.initials: AD
authors.lastname: Goddard
authors.forename: Anthony
authors.initials: A
authors.lastname: Watts
mesh_terms: D002460:Cell Line; D002784:Cholesterol / Q000378:metabolism*; D019204:GTP-Binding Proteins / Q000378:metabolism*; D006801:Humans; D054878:Lipoylation; D055503:Protein Multimerization; D011499:Protein Processing, Post-Translational; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D043562:Receptors, G-Protein-Coupled; D002784:Cholesterol; D019204:GTP-Binding Proteins