title: MR enterography correlates highly with colonoscopy and histology for both distal ileal and colonic Crohn's disease in 310 patients.
abstract: OBJECTIVE
  To evaluate the efficacy of MR enterography (MRE) in patients with known or suspected Crohn's disease without the use of anti-peristaltic pharmacologic agents compared to colonoscopy and histology.
  
  
  METHODS
  A retrospective review of 850 consecutive patients who underwent routine MRE to evaluate known or suspected Crohn's disease was performed. Of these, 310 patients also underwent colonoscopy with biopsy(s) within 90 days. The results of the MRE were compared to the colonoscopy and pathology reports to determine the presence or absence of disease in evaluable bowel segments. Individual imaging parameters (including wall thickening, enhancement, T2 signal, mesenteric vascular prominence and adenopathy) were also separately analyzed to determine their independent predictive value.
  
  
  RESULTS
  In 310 patients, the overall sensitivity and specificity of MRE (using endoscopy as a gold standard) were 85% and 80% respectively (kappa=0.65). The sensitivity of MRE for detection of pathologically severe disease was 87% in the terminal ileum (TI) and 88% in the colon. In the subset of 162 patients who underwent colonoscopy within 30 days of MRE, the overall sensitivity remained 85% but the specificity increased to 85% (kappa=0.69). Wall thickening and abnormal enhancement were sensitive indicators of Crohn's disease (75% and 78%), while abnormal T2 signal, mesenteric vascular prominence and adenopathy were specific (86%, 91% and 93%).
  
  
  CONCLUSIONS
  MRE compares favorably to colonoscopy for evaluation of known or suspected Crohn's disease noninvasively and without the exposure to ionizing radiation associated with CT enterography (CTE).
authors.affiliation: Department of Diagnostic Imaging, Warren Alpert School of Medicine, 593 Eddy St., Providence, RI 02903, United States. dgrand@lifespan.org
authors.forename: David J
authors.initials: DJ
authors.lastname: Grand
authors.forename: Vinay
authors.initials: V
authors.lastname: Kampalath
authors.forename: Adam
authors.initials: A
authors.lastname: Harris
authors.forename: Ajay
authors.initials: A
authors.lastname: Patel
authors.forename: Murray B
authors.initials: MB
authors.lastname: Resnick
authors.forename: Jason
authors.initials: J
authors.lastname: Machan
authors.forename: Michael
authors.initials: M
authors.lastname: Beland
authors.forename: William T
authors.initials: WT
authors.lastname: Chen
authors.forename: Samir A
authors.initials: SA
authors.lastname: Shah
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003092:Colitis / Q000175:diagnosis* / Q000453:epidemiology; D003113:Colonoscopy / Q000706:statistics & numerical data*; D003424:Crohn Disease / Q000175:diagnosis* / Q000453:epidemiology; D006801:Humans; D007079:Ileitis / Q000175:diagnosis* / Q000453:epidemiology; D008279:Magnetic Resonance Imaging / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012237:Rhode Island; D012680:Sensitivity and Specificity; D013223:Statistics as Topic; D055815:Young Adult