title: A pediatric patient with myopathy associated with antibodies to a signal recognition particle.
abstract: We report the case of a 15-year-old Japanese girl with myopathy associated with antibodies to a signal recognition particle (anti-SRP myopathy). The patient presented with progressive symmetrical proximal muscle weakness that caused difficulty in walking within 3 months, and marked elevation of the serum creatine kinase levels. A skeletal muscle biopsy revealed active necrotic and regenerating processes, with mild inflammatory changes. Based on the above findings, the patient was diagnosed as having anti-SRP myopathy. Only a limited number of pediatric patients with anti-SRP myopathy has been reported previously, with usually a poor prognosis. Early diagnosis is important for obtaining a better prognosis in patients with anti-SRP myopathy.
authors.affiliation: Department of Child Neurology, National Center Hospital, National Center of Neurology and Psychiatry, Kodaira, Tokyo, Japan.
authors.forename: Takayoshi
authors.initials: T
authors.lastname: Kawabata
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Komaki
authors.forename: Takashi
authors.initials: T
authors.lastname: Saito
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Saito
authors.forename: Eiji
authors.initials: E
authors.lastname: Nakagawa
authors.forename: Kenji
authors.initials: K
authors.lastname: Sugai
authors.forename: Masayuki
authors.initials: M
authors.lastname: Sasaki
authors.forename: Yukiko K
authors.initials: YK
authors.lastname: Hayashi
authors.forename: Ichizo
authors.initials: I
authors.lastname: Nishino
authors.forename: Mei
authors.initials: M
authors.lastname: Momomura
authors.forename: Toshitaka
authors.initials: T
authors.lastname: Kizawa
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Imagawa
authors.forename: Shumpei
authors.initials: S
authors.lastname: Yokota
mesh_terms: D000293:Adolescent; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology; D001706:Biopsy / Q000379:methods; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D006801:Humans; D018482:Muscle, Skeletal / Q000276:immunology / Q000473:pathology*; D009135:Muscular Diseases / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D018271:Signal Recognition Particle / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D018271:Signal Recognition Particle; D003402:Creatine Kinase