title: Host gene expression changes correlating with anti-HIV-1 effects in human subjects after treatment with peginterferon Alfa-2a.
abstract: We investigated whether interferon-inducible genes (IFIGs) with known anti-human immunodeficiency virus (HIV) activity in vitro were associated with in vivo virological response in HIV infection. Nine untreated HIV-1-infected volunteers were treated for 12 weeks with peginterferon alfa-2a. A subset of IFIGs (23 of 47) increased compared with baseline through 6 weeks beyond therapy, and 10 of the 23 IFIGs significantly inversely correlated (r = -0.7; P < .05) with virological response. The strength of peginterferon alfa-2a-induced IFIG response significantly correlated with declines in HIV load during treatment (r(2) = 0.87, p = .003). This study links HIV virological response to a specific IFIG subset, a potential prognostic indicator in peginterferon alfa-2a-treated patients with HIV infection.
authors.affiliation: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: Jonathan J
authors.initials: JJ
authors.lastname: Hubbard
authors.forename: Teresa
authors.initials: T
authors.lastname: Greenwell-Wild
authors.forename: Lisa
authors.initials: L
authors.lastname: Barrett
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.forename: Richard A
authors.initials: RA
authors.lastname: Lempicki
authors.forename: Sharon M
authors.initials: SM
authors.lastname: Wahl
authors.forename: David M
authors.initials: DM
authors.lastname: Asmuth
authors.forename: Robert L
authors.initials: RL
authors.lastname: Murphy
authors.forename: Richard B
authors.initials: RB
authors.lastname: Pollard
authors.forename: Shyam
authors.initials: S
authors.lastname: Kottilil
mesh_terms: D000998:Antiviral Agents / Q000008:administration & dosage*; D005786:Gene Expression Regulation / Q000187:drug effects*; D015658:HIV Infections / Q000188:drug therapy; D015497:HIV-1 / Q000302:isolation & purification / Q000472:pathogenicity*; D054884:Host-Pathogen Interactions / Q000235:genetics*; D006801:Humans; D016898:Interferon-alpha / Q000008:administration & dosage*; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D011092:Polyethylene Glycols / Q000008:administration & dosage*; D012367:RNA, Viral / Q000235:genetics / Q000302:isolation & purification; D011994:Recombinant Proteins / Q000008:administration & dosage; D019562:Viral Load
chemical_list: D000998:Antiviral Agents; D016898:Interferon-alpha; D012367:RNA, Viral; D011994:Recombinant Proteins; D011092:Polyethylene Glycols; C100416:peginterferon alfa-2a