title: Computed tomographic perfusion imaging for the therapeutic response of chemoembolization for hepatocellular carcinoma.
abstract: BACKGROUND
  Computed tomographic (CT) perfusion imaging has been applied in many clinical areas, but few studies have addressed the values of CT perfusion imaging in evaluating the therapeutic response of chemoembolization for hepatocellular carcinoma (HCC).
  
  
  OBJECTIVE
  To assess the perfusion changes of HCC after transarterial chemoembolization, and to investigate the values of CT perfusion imaging in chemoembolization procedure.
  
  
  METHODS
  Multidetector computed tomographic perfusion imaging was performed in 24 patients with HCC 1 week before and 4 weeks after chemoembolization. The CT perfusion parameters, including hepatic arterial perfusion (HAP), hepatic portal perfusion (HPP), total liver perfusion (TLP), and hepatic arterial perfusion index (HAPI), were calculated by using the slope method. The t statistic was used to analysis the difference of CT perfusion parameter values before and after chemoembolization therapy.
  
  
  RESULTS
  The values of HAP, TLP, and HAPI in tumors 4 weeks after chemoembolization were significantly decreased than those before chemoembolization (P < 0.05), but the value of HPP in tumors was not (P > 0.05).
  
  
  CONCLUSIONS
  Computed tomographic perfusion imaging has the ability to evaluate the perfusion changes in HCC after chemoembolization, which can be used to evaluate the therapeutic response of chemoembolization for hepatocellular carcinoma.
authors.affiliation: Sichuan Key Laboratory of Medical Imaging, Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, PR China. linyangchn@126.com
authors.forename: Lin
authors.initials: L
authors.lastname: Yang
authors.forename: Xiao-ming
authors.initials: XM
authors.lastname: Zhang
authors.forename: Bang-xian
authors.initials: BX
authors.lastname: Tan
authors.forename: Mi
authors.initials: M
authors.lastname: Liu
authors.forename: Guo-li
authors.initials: GL
authors.lastname: Dong
authors.forename: Zhao-hua
authors.initials: ZH
authors.lastname: Zhai
mesh_terms: D000328:Adult; D000368:Aged; D002166:Camptothecin / Q000008:administration & dosage; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy*; D016461:Chemoembolization, Therapeutic / Q000379:methods*; D004317:Doxorubicin / Q000008:administration & dosage; D004998:Ethiodized Oil / Q000008:administration & dosage; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D005781:Gelatin Sponge, Absorbable / Q000008:administration & dosage; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014057:Tomography, X-Ray Computed / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D004998:Ethiodized Oil; D004317:Doxorubicin; D005472:Fluorouracil; D002166:Camptothecin