title: Differentiating rectal carcinoma by an immunohistological analysis of carcinomas of pelvic organs based on the NCBI Literature Survey and the Human Protein Atlas database.
abstract: The treatments and prognoses of pelvic organ carcinomas differ, depending on whether the primary tumor originated in the rectum, urinary bladder, prostate, ovary, or uterus; therefore, it is essential to diagnose pathologically the primary origin and stages of these tumors. To establish the panels of immunohistochemical markers for differential diagnosis, we reviewed 91 of the NCBI articles on these topics and found that the results correlated closely with those of the public protein database, the Human Protein Atlas. The results revealed the panels of immunohistochemical markers for the differential diagnosis of rectal adenocarcinoma, in which [+] designates positivity in rectal adenocarcinoma and [-] designates negativity in rectal adenocarcinoma: from bladder adenocarcinoma, CDX2[+], VIL1[+], KRT7[-], THBD[-] and UPK3A[-]; from prostate adenocarcinoma, CDX2[+], VIL1[+], CEACAM5[+], KLK3(PSA)[-], ACPP(PAP)[-] and SLC45A3(prostein)[-]; and from ovarian mucinous adenocarcinoma, CEACAM5[+], VIL1[+], CDX2[+], KRT7[-] and MUC5AC[-]. The panels of markers distinguishing ovarian serous adenocarcinoma, cervical carcinoma, and endometrial adenocarcinoma were also represented. Such a comprehensive review on the differential diagnosis of carcinomas of pelvic organs has not been reported before. Thus, much information has been accumulated in public databases to provide an invaluable resource for clinicians and researchers.
authors.affiliation: Department of Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, Japan. k-miura@surg1.med.tohoku.ac.jp
authors.forename: Koh
authors.initials: K
authors.lastname: Miura
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Ishida
authors.forename: Wataru
authors.initials: W
authors.lastname: Fujibuchi
authors.forename: Akihiro
authors.initials: A
authors.lastname: Ito
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Niikura
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Ogawa
authors.forename: Iwao
authors.initials: I
authors.lastname: Sasaki
mesh_terms: D000230:Adenocarcinoma / Q000737:chemistry* / Q000235:genetics* / Q000556:secondary; D014408:Biomarkers, Tumor / Q000032:analysis*; D003937:Diagnosis, Differential; D016889:Endometrial Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology; D005260:Female; D052138:Genes, Neoplasm / Q000235:genetics*; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008297:Male; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology; D011471:Prostatic Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology; D012004:Rectal Neoplasms / Q000737:chemistry* / Q000235:genetics* / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor