title: Alternative chemotherapeutic agents: nitrosoureas, cisplatin, irinotecan.
abstract: Irinotecan, cisplatin, and nitrosoureas have a long history of use in brain tumors, with demonstrated efficacy in the adjuvant treatment of malignant gliomas. In the era of temozolomide with concurrent radiotherapy given as the standard of care, their use has shifted to treatment at progression or recurrence. Now with the widespread use of bevacizumab in the recurrent setting, irinotecan and other chemotherapies are seeing increased use in combination with bevacizumab and alone in the recurrent setting. The activity of these chemotherapeutic agents in brain tumors will likely ensure a place in the armamentarium of neuro-oncologists for many years.
authors.affiliation: Department of Neurology, University of California Irvine, 101 The City Drive South, Shanbrom Hall, Suite 121, Orange, CA 92868, USA. carrilj2@hs.uci.edu
authors.forename: Jose A
authors.initials: JA
authors.lastname: Carrillo
authors.forename: Claudia A
authors.initials: CA
authors.lastname: Munoz
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000188:drug therapy*; D002166:Camptothecin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002945:Cisplatin / Q000627:therapeutic use*; D005910:Glioma / Q000188:drug therapy*; D006801:Humans; D000077146:Irinotecan; D009607:Nitrosourea Compounds / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D009607:Nitrosourea Compounds; D000077146:Irinotecan; D002945:Cisplatin; D002166:Camptothecin