title: Type17 T-cells in central nervous system autoimmunity and tumors.
abstract: Interleukin-17 (IL-17) producing Type17 T-cells, specifically T-helper (Th)17 cells reactive to central nervous system (CNS) autoantigens, manifest a higher migratory capability to the CNS parenchyma compared with other T-cell subpopulations due to their ability to penetrate the blood brain barrier (BBB). In the field of cancer immunotherapy, there are now a number of cell therapy approaches including early studies using T-cells transduced with chimeric antigen receptors in hematologic malignancy, suggesting that the use of T-cells or genetically modified T-cells could have a significant role in effective cancer therapy. However, the successful application of this strategy in solid tumors, such as CNS tumors, requires careful consideration of critical factors to improve the tumor-homing of T-cells. The current review is dedicated to discuss recent findings on the role of Type17 T-cells in CNS autoimmunity and cancer. The insight gained from these findings may lead to the development of novel therapeutic and prophylactic strategies for CNS autoimmunity and tumors.
authors.affiliation: Department of Neurological Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. okadah@upmc.edu
authors.forename: Hideho
authors.initials: H
authors.lastname: Okada
authors.forename: Samia J
authors.initials: SJ
authors.lastname: Khoury
mesh_terms: D000818:Animals; D001324:Autoantigens / Q000276:immunology; D020274:Autoimmune Diseases of the Nervous System / Q000276:immunology* / Q000628:therapy; D015551:Autoimmunity; D001812:Blood-Brain Barrier / Q000276:immunology; D001921:Brain / Q000276:immunology; D001932:Brain Neoplasms / Q000276:immunology* / Q000628:therapy; D002465:Cell Movement; D005910:Glioma / Q000276:immunology; D006801:Humans; D007167:Immunotherapy; D020381:Interleukin-17 / Q000096:biosynthesis*; D051379:Mice; D009103:Multiple Sclerosis / Q000276:immunology; D058504:Th17 Cells / Q000276:immunology*
chemical_list: D001324:Autoantigens; D020381:Interleukin-17