title: The biology of protein kinase C.
abstract: This review gives a basic introduction to the biology of protein kinase C, one of the first calcium-dependent kinases to be discovered. We review the structure and function of protein kinase C, along with some of the substrates of individual isoforms. We then review strategies for inhibiting PKC in experimental systems and finally discuss the therapeutic potential of targeting PKC. Each aspect is covered in summary, with links to detailed resources where appropriate.
authors.affiliation: School of Medicine, University of California, San Francisco, CA, USA.
authors.forename: Lily
authors.initials: L
authors.lastname: Zeng
authors.forename: Samuel V
authors.initials: SV
authors.lastname: Webster
authors.forename: Philip M
authors.initials: PM
authors.lastname: Newton
mesh_terms: D000818:Animals; D019337:Hematologic Neoplasms / Q000188:drug therapy; D006801:Humans; D007333:Insulin Resistance; D019636:Neurodegenerative Diseases / Q000188:drug therapy; D010766:Phosphorylation; D011493:Protein Kinase C / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000502:physiology*; D019966:Substance-Related Disorders / Q000188:drug therapy
chemical_list: D011493:Protein Kinase C