title: [Antimicrobial treatment in burn injury patients].
abstract: Infections are a great diagnostic and therapeutic challenge in intensive care patients with burn injuries. The major problems are due to bacteria with hospital-acquired multiresistance to antibiotics but fungal and viral infections may also be life-threatening. The main key points addressing pharmacotherapy with antibiotic, antifungal and antiviral agents in this special setting are exact diagnosis, early therapy with suitable drugs, adequate duration of treatment and adequate doses based on pharmacokinetic and pharmacodynamic characteristics of these compounds. The latter parameters are significantly altered in burn patients and show a wide interindividual and intraindividual variation in drug response as a result of the characteristic phases of burn injury. Drug concentration analysis may help to avoid inadequate dosing. In this review the main characteristics of burn injuries and the pharmacology of antibiotics, antifungal and antiviral agents in these patients are presented.
authors.affiliation: Abteilung für Anästhesie, Intensivmedizin und Schmerztherapie, Berufsgenossenschaftliche Unfallklinik Ludwigshafen, Deutschland.
authors.forename: T
authors.initials: T
authors.lastname: Trupkovic
authors.forename: J
authors.initials: J
authors.lastname: Gille
authors.forename: H
authors.initials: H
authors.lastname: Fischer
authors.forename: S
authors.initials: S
authors.lastname: Kleinschmidt
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D019072:Antibiotic Prophylaxis; D000935:Antifungal Agents / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D001424:Bacterial Infections / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D002056:Burns / Q000150:complications* / Q000188:drug therapy*; D002059:Burns, Inhalation / Q000150:complications / Q000628:therapy; D006801:Humans; D007239:Infections / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy*; D009181:Mycoses / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D019990:Perioperative Care; D012307:Risk Factors; D014777:Virus Diseases / Q000453:epidemiology / Q000209:etiology / Q000628:therapy
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D000998:Antiviral Agents