title: Genetic variants in the ADIPOQ gene and the risk of metabolic syndrome: a case-control study of a Chinese Han population.
abstract: Our aim was to investigate whether the ADIPOQ gene polymorphisms are associated with the metabolic syndrome (MetS). Genotypes of MetS patients (n=1049) and normal controls (n= 1092) were analysed by TaqMan® assay, and serum adiponectin concentration was measured by ELISA. The variant genotypes rs266729CG; rs1063539GC, GC/CC; rs16861205AA and rs7649121AT, AT/TT (Adjusted P=0.037, 0.044, 0.025, 0.011, 0.019, 0.020, respectively) of the ADIPOQ gene were associated with MetS. Patients with rs266729CG, CG/GG genotypes (P=0.034, 0.035) and rs7649121AT, AT/TT genotypes (P=0.013, 0.022) had higher levels of serum adiponectin than those with the CC and AA genotypes respectively. Furthermore, the prevalence of haplotypes GGAAAATC and GGGTAACC was lower in cases (10.7% and 4.5%) than in controls (12.1% and 5.9%) [Adjusted ORs (95% CIs)=0.70 (0.54–0.91), 0.65 (0.46–0.92)]. The ADIPOQ gene variants associated with the risk of MetS in this study must be validated by further functional studies to reveal any potential effects on metabolism.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, and Department of Incretion, the Affiliated Nanjing First Hospital of NJMU, Nanjing, Jiangsu, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Du
authors.forename: Xin hua
authors.initials: Xh
authors.lastname: Ye
authors.forename: Qian
authors.initials: Q
authors.lastname: Li
authors.forename: Xiaofang
authors.initials: X
authors.lastname: Yu
authors.forename: Jinluo
authors.initials: J
authors.lastname: Cheng
authors.forename: Jianhua
authors.initials: J
authors.lastname: Ma
authors.forename: Yanqin
authors.initials: Y
authors.lastname: Gao
authors.forename: Ying
authors.initials: Y
authors.lastname: Lu
authors.forename: Wencong
authors.initials: W
authors.lastname: Du
authors.forename: Hui
authors.initials: H
authors.lastname: Shi
authors.forename: Xu
authors.initials: X
authors.lastname: Zhao
authors.forename: Qing
authors.initials: Q
authors.lastname: Ye
authors.forename: Ling
authors.initials: L
authors.lastname: Zhou
mesh_terms: D052242:Adiponectin / Q000097:blood / Q000235:genetics*; D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D052242:Adiponectin