title: Role of store-operated calcium entry during meiotic progression and fertilization of mammalian oocytes.
abstract: Calcium signaling is essential for many cellular events, including muscle contraction, secretion of hormones and neurotransmitters, and fertilization of oocytes. For the appropriate maturation and fertilization of mammalian oocytes, the influx of extracellular calcium through plasma membrane Ca(2+) channels is required. Although the molecular pathway of the Ca(2+) entry in other cell types has been reported, Ca(2+) channels involved in the regulation of Ca(2+) influx in oocytes have remained unknown for a long time. In this review, we summarize recent findings regarding the occurrence of store-operated calcium entry (SOCE) in mammalian oocytes and the expression and localization profiles of STIM1 and ORAI1, two important proteins that control SOCE. As we discuss here, STIM1, as an endoplasmic reticulum Ca(2+) sensor, and ORAI1, the major plasma Ca(2+) channel involved in SOCE, might help to explain the role of Ca(2+) entry in mammalian oocyte maturation and fertilization.
authors.affiliation: Department of Biochemistry and Molecular Biology, School of Life Sciences, University of Extremadura, Badajoz, Spain.
authors.forename: Francisco Javier
authors.initials: FJ
authors.lastname: Martín-Romero
authors.forename: Aida M
authors.initials: AM
authors.lastname: López-Guerrero
authors.forename: Ignacio S
authors.initials: IS
authors.lastname: Alvarez
authors.forename: Eulalia
authors.initials: E
authors.lastname: Pozo-Guisado
mesh_terms: D000818:Animals; D020013:Calcium Signaling; D002454:Cell Differentiation; D005306:Fertilization / Q000502:physiology*; D006801:Humans; D008322:Mammals / Q000502:physiology*; D008540:Meiosis; D009865:Oocytes / Q000166:cytology* / Q000378:metabolism*