title: [The latest developments in glaucoma therapy using fixed combination products].
abstract: Modern fixed-combination products simplify medication dose regimen without sacrificing their effectiveness.Potential benefits of the therapy with fixed-combination products are enhanced tolerability increased convenience,better compliance,cost and time economy and removal of the wash out effect. Regarding intraocular pressure lowering effect, fixed-combination agents are superior to monotherapy with the two medication components, with the exception of Duotrav that is not superior to travoprost action.Fixed-combination products are noninferior to concomitant administration of the two components of medication (nonfixed-combination agents) relative to their ocular hypotensive efficacy with the exception of Ganfort that is however inferior to concurrent administration of both the bimatoprost and timolol.
authors.forename: M
authors.initials: M
authors.lastname: Călugăru
authors.forename: D
authors.initials: D
authors.lastname: Călugăru
mesh_terms: D000577:Amides / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000069580:Bimatoprost; D000068599:Brimonidine Tartrate, Timolol Maleate Drug Combination; D002257:Carbonic Anhydrase Inhibitors / Q000627:therapeutic use; D003008:Cloprostenol / Q000031:analogs & derivatives / Q000627:therapeutic use; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D005901:Glaucoma / Q000188:drug therapy; D005902:Glaucoma, Open-Angle / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D000077338:Latanoprost; D009883:Ophthalmic Solutions / Q000008:administration & dosage; D011461:Prostaglandins F, Synthetic / Q000627:therapeutic use; D011810:Quinoxalines / Q000627:therapeutic use; D013449:Sulfonamides / Q000627:therapeutic use; D013843:Thiazines / Q000627:therapeutic use; D013876:Thiophenes / Q000627:therapeutic use; D013999:Timolol / Q000627:therapeutic use; D000069557:Travoprost; D016896:Treatment Outcome
chemical_list: D000577:Amides; D000959:Antihypertensive Agents; D000068599:Brimonidine Tartrate, Timolol Maleate Drug Combination; D002257:Carbonic Anhydrase Inhibitors; D004338:Drug Combinations; C571754:Duotrav; C571755:Ganfort; D009883:Ophthalmic Solutions; D011461:Prostaglandins F, Synthetic; D011810:Quinoxalines; D013449:Sulfonamides; D013843:Thiazines; D013876:Thiophenes; C571753:Xalacom; C479140:dorzolamide-timolol combination; D003008:Cloprostenol; D000077338:Latanoprost; D013999:Timolol; C111827:brinzolamide; D000069580:Bimatoprost; D000069557:Travoprost