title: [Effects of CdTe QDs on oxidative stress and DNA damage of liver cells in mice].
abstract: OBJECTIVE
  To investigate the effects of CdTe QDs (cadmium telluride quantum dots) on oxidative stress and DNA damage of liver cells in mice.
  
  
  METHODS
  Thirty ICR male mice were randomly divided into 5 groups: one negative control (normal saline) group. Three CdTe QDs groups (exposed by intravenous injection of 0.2 ml of CdTe QDs at the concentration of 3.75, 37.5 and 375 nmol/ml respectively) for electron paramagnetic resonance (EPR) test, and another positive control group (exposed by intravenous injection of 0.2 ml of cyclophosphamide 20 mg/ml) for single cell gel electrophoresis (SCGE) test. All mice were decapitated 24h after the injection, free radicals and DNA damage of liver cells were detected by EPR and SCGE.
  
  
  RESULTS
  The levels of oxygen free radicals detected by EPR were increased with the increase of CdTe QDs. The tail length, olive tail moment, tail DNA (%) and the ratio of tail/head examined by SCGE were also increased with the increase of the dosage of CdTe QDs (P < 0.01).
  
  
  CONCLUSIONS
  CdTe QDs could induce oxidative stress and DNA damage of liver cells in mice with a dose-effect relationship.
authors.affiliation: School of Public and Familay Medince, Capital Medical University, Beijing 100069, China. guangyunxie@163.com
authors.forename: Guangyun
authors.initials: G
authors.lastname: Xie
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
authors.forename: Yang
authors.initials: Y
authors.lastname: Xiao
authors.forename: Ying
authors.initials: Y
authors.lastname: Han
authors.forename: Na
authors.initials: N
authors.lastname: Liu
authors.forename: Bin
authors.initials: B
authors.lastname: Li
authors.forename: Ying
authors.initials: Y
authors.lastname: Mu
authors.forename: Sihai
authors.initials: S
authors.lastname: Han
authors.forename: Peili
authors.initials: P
authors.lastname: Huang
authors.forename: Zhiwei
authors.initials: Z
authors.lastname: Sun
mesh_terms: D000818:Animals; D019187:Cadmium Compounds / Q000633:toxicity*; D004249:DNA Damage / Q000187:drug effects*; D022781:Hepatocytes / Q000187:drug effects*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D018384:Oxidative Stress / Q000187:drug effects*; D045663:Quantum Dots; D013691:Tellurium / Q000633:toxicity*
chemical_list: D019187:Cadmium Compounds; D013691:Tellurium; C028337:cadmium telluride