title: Intestinal T-cell lymphoma with severe hypereosinophilic syndrome in a cat.
abstract: A Japanese domestic long-hair cat of about 8 years of age was presented with vomiting and hematochezia and was found to have significant hypereosinophilia. Bone marrow aspiration revealed moderate increases of eosinophilic lineages. Histopathological examination revealed mild eosinophilic and epitheliotropic T-lymphocytic infiltrations in the duodenum. Although the cat remained asymptomatic with only prednisolone administration, the cat presented with hematemesis, weight loss, and severe anorexia 512 days after the initial presentation. Subsequently, gastrointestinal perforation developed, and the cat died on Day 536. Histopathological examination of autopsy specimens revealed mixed cellular infiltration including eosinophils and neoplastic lymphocytes in the intestinal lymph nodes, intestine, liver, spleen, and pancreas. Immunohistochemical examination supports a diagnosis of intestinal T-cell lymphoma with severe hypereosinophilic syndrome.
authors.affiliation: Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Tokyo 113-8657, Japan.
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Takeuchi
authors.forename: Masashi
authors.initials: M
authors.lastname: Takahashi
authors.forename: Masaya
authors.initials: M
authors.lastname: Tsuboi
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Fujino
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Uchida
authors.forename: Koichi
authors.initials: K
authors.lastname: Ohno
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Nakayama
authors.forename: Hajime
authors.initials: H
authors.lastname: Tsujimoto
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000473:pathology*; D002415:Cats; D004379:Duodenal Neoplasms / Q000473:pathology / Q000662:veterinary*; D017809:Fatal Outcome; D017681:Hypereosinophilic Syndrome / Q000150:complications / Q000662:veterinary*; D007416:Intestinal Perforation / Q000473:pathology / Q000662:veterinary; D016399:Lymphoma, T-Cell / Q000150:complications / Q000473:pathology / Q000662:veterinary*