title: Maternal hypertension induces tissue-specific modulations of the apelinergic system in the fetoplacental unit in rat.
abstract: Apelin and its receptor APJ are expressed in fetal tissues but their function and regulation remain largely unknown. In rat, maternal treatment with a nitric oxide synthase inhibitor inducing hypertension was used to investigate apelin plasma levels in mother/fetus pairs and on the gene expression level of the apelin/APJ system in fetal tissues and placenta. At term, plasma levels of apelin were not modulated but APJ expression was increased in placenta and lung but reduced in heart. Apelin expression was increased only in the heart. We postulate that the apelinergic system may control fetal growth and cardiovascular functions in utero.
authors.affiliation: Univ Lille Nord de France, Unité Environnement Périnatal et Croissance, EA 4489, Equipe dénutritions maternelles périnatales, Université de Lille 1, Bâtiment SN4, F-59655 Villeneuve d'Ascq, France.
authors.forename: Joanna
authors.initials: J
authors.lastname: Ivars
authors.forename: Laura
authors.initials: L
authors.lastname: Butruille
authors.forename: Claude
authors.initials: C
authors.lastname: Knauf
authors.forename: Thomas
authors.initials: T
authors.lastname: Bouckenooghe
authors.forename: Sylvain
authors.initials: S
authors.lastname: Mayeur
authors.forename: Didier
authors.initials: D
authors.lastname: Vieau
authors.forename: Philippe
authors.initials: P
authors.lastname: Valet
authors.forename: Philippe
authors.initials: P
authors.lastname: Deruelle
authors.forename: Jean
authors.initials: J
authors.lastname: Lesage
mesh_terms: D002001:Adipose Tissue, Brown / Q000378:metabolism; D000818:Animals; D000073861:Apelin; D000075244:Apelin Receptors; D005260:Female; D005318:Fetal Heart / Q000378:metabolism; D005333:Fetus / Q000378:metabolism; D051456:Gene Flow; D046110:Hypertension, Pregnancy-Induced / Q000097:blood* / Q000139:chemically induced / Q000378:metabolism; D036341:Intercellular Signaling Peptides and Proteins / Q000097:blood* / Q000235:genetics; D008168:Lung / Q000378:metabolism; D019331:NG-Nitroarginine Methyl Ester; D009928:Organ Specificity; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D043562:Receptors, G-Protein-Coupled / Q000235:genetics / Q000378:metabolism*
chemical_list: D000073861:Apelin; D000075244:Apelin Receptors; C498579:Apln protein, rat; C491284:Aplnr protein, rat; D036341:Intercellular Signaling Peptides and Proteins; D043562:Receptors, G-Protein-Coupled; D019331:NG-Nitroarginine Methyl Ester