title: High serum thioredoxin levels are reduced after tonsillectomy in patients with IgA nephropathy.
abstract: OBJECTIVE
  The role of oxidative stress in IgA nephropathy (IgAN), the most common type of primary glomerulonephritis, is unknown. We evaluated the clinical significance of serum levels of oxidative stress markers, thioredoxin (TRX) and manganese superoxide dismutase (MnSOD), in patients with IgAN.
  
  
  METHODS
  Forty-eight patients with histologically confirmed IgAN and 14 healthy subjects were enrolled in this study. Serum samples from 14 IgAN patients were obtained after tonsillectomy, a procedure hypothesized to be an effective treatment for IgAN.
  
  
  RESULTS
  Serum TRX levels were significantly higher in patients with IgAN than in healthy subjects (mean [ng/mL]; 49.5 vs.14.4, p<0.001). Serum TRX levels are positively correlated with blood urea nitrogen, serum uric acid and proteinuria, and negatively with estimated glomerular filtration rate (eGFR). In addition, serum TRX levels gradually increased as the severity of renal histology increased. High levels of serum TRX were significantly decreased after tonsillectomy in patients with IgAN (mean [ng/mL]; 55.5 to 41.1, p=0.02). In contrast, serum MnSOD levels did not differ between IgAN patients and healthy subjects, and these levels did not change after tonsillectomy in IgAN patients.
  
  
  CONCLUSIONS
  Serum TRX is associated with IgAN, and tonsillectomy may decrease oxidative stress in IgAN patients, leading to clinical improvement.
authors.affiliation: Digestive and Lifestyle Diseases, Human and Environmental Sciences, Health Research, Japan.
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Nosaki
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Uto
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Takami
authors.forename: Manei
authors.initials: M
authors.lastname: Oku
authors.forename: Mayumi
authors.initials: M
authors.lastname: Fukumoto
authors.forename: Kumiko
authors.initials: K
authors.lastname: Mera
authors.forename: Chika
authors.initials: C
authors.lastname: Nishida
authors.forename: Koki
authors.initials: K
authors.lastname: Tokunaga
authors.forename: Atsushi
authors.initials: A
authors.lastname: Sogabe
authors.forename: Makoto
authors.initials: M
authors.lastname: Oketani
authors.forename: Akio
authors.initials: A
authors.lastname: Ido
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Kurono
authors.forename: Hirohito
authors.initials: H
authors.lastname: Tsubouchi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers; D001798:Blood Proteins / Q000032:analysis; D005260:Female; D005922:Glomerulonephritis, IGA / Q000097:blood* / Q000150:complications / Q000601:surgery; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D011507:Proteinuria / Q000209:etiology; D012189:Retrospective Studies; D013482:Superoxide Dismutase / Q000097:blood; D013879:Thioredoxins / Q000097:blood*; D014068:Tonsillectomy; D055815:Young Adult
chemical_list: D015415:Biomarkers; D001798:Blood Proteins; D008055:Lipids; D013879:Thioredoxins; D013482:Superoxide Dismutase