title: MRI diffusion indices sampled along streamline trajectories: quantitative tractography mapping.
abstract: Abstract   Several useful tractography-derived maps have recently been introduced, such as track density imaging (TDI) and the average pathlength map (APM). Here, an extension to these techniques is introduced by sampling diffusion indices along streamline trajectories (DIST). With this approach, voxels contain summary information of diffusivity measures within streamlines. The diffusion metrics can also be used as weighting factors for streamline number or length, generating DIST-weighted TDI and DIST-weighted APM, respectively. Furthermore, when higher-order models of diffusion are used to estimate the fiber orientation distribution within each voxel, it is possible to obtain directional TDI, APM, DIST, and DIST-weighted TDI and APM. The reproducibility of this approach using two b-values (1000 and 3000 s/mm(2)) and the effect of pathologic abnormalities are demonstrated.
authors.affiliation: The University of Queensland, Centre for Clinical Research, Brisbane, Australia.
authors.forename: Kerstin
authors.initials: K
authors.lastname: Pannek
authors.forename: Jane L
authors.initials: JL
authors.lastname: Mathias
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Rose
mesh_terms: D001921:Brain / Q000502:physiology*; D001930:Brain Injuries / Q000175:diagnosis / Q000503:physiopathology; D001931:Brain Mapping / Q000379:methods; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D056324:Diffusion Tensor Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D055815:Young Adult