title: Association of thrombophilia and polycystic ovarian syndrome in women with history of recurrent pregnancy loss.
abstract: OBJECTIVE
  To evaluate the prevalence of thrombophilic disorders in polycystic ovarian syndrome (PCOS) women with history of recurrent pregnancy loss (RPL).
  
  
  METHODS
  This study was carried out in 184 women with history of RPL, of which 92 of them were diagnosed with PCOS and 92 patients were without known PCOS. The prevalence of thrombophilic disorders was compared between the two mentioned groups.
  
  
  RESULTS
  According to the findings, 70.7% of PCOS women with history of RPL had thrombophilic disorders. The prevalence of protein C deficiency was significantly higher in PCOS group compared to the non-PCOS group (21.7% vs. 10.9%, p = 0.04). There was a trend toward higher prevalence of protein S deficiency in PCOS group compared to the control group, but the difference did not reach statistical significance (23.9% vs. 13%, p = 0.05). The prevalence of other thrombophilic disorders such as antithrombin III deficiency, homocysteine elevation, antiphospholipid antibody and Factor V Leiden was comparable between groups.
  
  
  CONCLUSIONS
  The prevalence of thrombophilic disorders was more common in PCOS women than the normal group. The protein C deficiency is associated with PCOS in women with history of RPL. There was a trend toward higher prevalence of protein S deficiency in PCOS women, which needs further study.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. a_moini@royaninstitue.org
authors.forename: Ashraf
authors.initials: A
authors.lastname: Moini
authors.forename: Shahin
authors.initials: S
authors.lastname: Tadayon
authors.forename: Afsaneh
authors.initials: A
authors.lastname: Tehranian
authors.forename: Ladan Mohammadi
authors.initials: LM
authors.lastname: Yeganeh
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Akhoond
authors.forename: Reza Salman
authors.initials: RS
authors.lastname: Yazdi
mesh_terms: D000026:Abortion, Habitual / Q000209:etiology*; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008875:Middle Aged; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D015995:Prevalence; D020151:Protein C Deficiency / Q000150:complications / Q000453:epidemiology; D018455:Protein S Deficiency / Q000150:complications / Q000453:epidemiology; D019851:Thrombophilia / Q000150:complications* / Q000453:epidemiology