title: Role of cyclooxygenase 2 and endothelial nitric oxide synthetase in preclinical atherosclerosis.
abstract: Cyclooxygenase-2 and endothelial nitric oxide (NO) synthase enzymes may have a role in developing preclinical atherosclerosis. Designed groups were as follows: smoke exposed rats before and during pregnancy, only before pregnancy, and controls. Cross-sectional samples of abdominal aorta were examined immunohistochemically. Cyclooxygenase-2 and eNOS expression was evaluated semi-quantitatively through staining extent (focal, diffuse) and staining intensity. Diffuse COX-2 expression was detected in study groups. Endothelial NO synthase expression was diffuse in study groups. COX-2 and eNOS may contribute to the formation of preatherosclerotic lesions in offspring of rats exposed to cigarette smoke through inflammatory response.
authors.affiliation: Department of Pediatrics, Gulhane Military Medical Academy, Etlik, Turkey.
authors.forename: Abdulbaki
authors.initials: A
authors.lastname: Karaoglu
authors.forename: Turan
authors.initials: T
authors.lastname: Tunc
authors.forename: Gokhan
authors.initials: G
authors.lastname: Aydemir
authors.forename: Onder
authors.initials: O
authors.lastname: Onguru
authors.forename: Bulent
authors.initials: B
authors.lastname: Uysal
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kul
authors.forename: Secil
authors.initials: S
authors.lastname: Aydinoz
authors.forename: Emin
authors.initials: E
authors.lastname: Oztas
authors.forename: Umit
authors.initials: U
authors.lastname: Sarici
mesh_terms: D000818:Animals; D000833:Animals, Suckling; D001012:Aorta, Abdominal / Q000187:drug effects / Q000201:enzymology* / Q000473:pathology; D050197:Atherosclerosis / Q000139:chemically induced / Q000201:enzymology*; D003367:Cotinine / Q000652:urine; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D004195:Disease Models, Animal; D004730:Endothelium, Vascular / Q000187:drug effects / Q000201:enzymology* / Q000473:pathology; D005260:Female; D052250:Nitric Oxide Synthase Type III / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D012906:Smoke / Q000009:adverse effects*; D014026:Nicotiana
chemical_list: D012906:Smoke; D052250:Nitric Oxide Synthase Type III; C496316:Nos3 protein, rat; D051546:Cyclooxygenase 2; C489691:Ptgs2 protein, rat; D003367:Cotinine