title: Loss of temporal retinal nerve fibers in Parkinson disease: a mitochondrial pattern?
abstract: OBJECTIVE
  Optic nerve involvement is frequent in mitochondrial disease, and retinal abnormalities are described in Parkinson's disease (PD).
  
  
  METHODS
  We evaluated retinal nerve fiber layer (RNFL) thickness by optical coherence tomography in 43 patients with PD and in 86 age-matched controls. We considered separately the eyes ipsilateral and contralateral to the most affected body side in patients with PD. ancova analysis, Pearson test, and multiple regression analysis were used (P < 0.05).
  
  
  RESULTS
  Patients with PD showed significantly thinner temporal RNFL thickness compared to controls (P = 0.004), more evident in the eye contralateral to the most affected body side. Average RNFL thickness significantly correlated with age in both controls and patients with PD (P-values ranging from 0.001 to 0.019), whereas in patients with PD RNFL thickness did not correlate with clinical variables.
  
  
  CONCLUSIONS
  Our study reveals a loss of retinal nerve fibers in the temporal quadrant in PD, which is typically susceptible in mitochondrial optic neuropathies.
authors.affiliation: IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.
authors.forename: C
authors.initials: C
authors.lastname: La Morgia
authors.forename: P
authors.initials: P
authors.lastname: Barboni
authors.forename: G
authors.initials: G
authors.lastname: Rizzo
authors.forename: M
authors.initials: M
authors.lastname: Carbonelli
authors.forename: G
authors.initials: G
authors.lastname: Savini
authors.forename: C
authors.initials: C
authors.lastname: Scaglione
authors.forename: S
authors.initials: S
authors.lastname: Capellari
authors.forename: S
authors.initials: S
authors.lastname: Bonazza
authors.forename: M P
authors.initials: MP
authors.lastname: Giannoccaro
authors.forename: G
authors.initials: G
authors.lastname: Calandra-Buonaura
authors.forename: R
authors.initials: R
authors.lastname: Liguori
authors.forename: P
authors.initials: P
authors.lastname: Cortelli
authors.forename: P
authors.initials: P
authors.lastname: Martinelli
authors.forename: A
authors.initials: A
authors.lastname: Baruzzi
authors.forename: V
authors.initials: V
authors.lastname: Carelli
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D009412:Nerve Fibers / Q000473:pathology*; D009900:Optic Nerve / Q000473:pathology*; D009901:Optic Nerve Diseases / Q000209:etiology*; D010300:Parkinson Disease / Q000150:complications*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics; D012160:Retina / Q000473:pathology*; D041623:Tomography, Optical Coherence
chemical_list: C495280:LRRK2 protein, human; D000071158:Leucine-Rich Repeat Serine-Threonine Protein Kinase-2; D017346:Protein Serine-Threonine Kinases