title: Physical fitness is independently related to blood leptin concentration and insulin sensitivity index in male subjects with central adiposity.
abstract: OBJECTIVE
  To compare the maximal power output (MPO) of subjects presenting a central adiposity to those of controls and to study the links between plasma leptin or indices of insulin sensitivity (QUICKI) and physical fitness (PF).
  
  
  METHODS
  MPO was determined for 169 middle-aged men divided into two groups according to waist circumference (WC- < 94 cm, WC+ ≥ 94 cm) each subdivided in two subgroups with low and high PF (WC-L, WC-H, WC+L, WC+H) determined from the median MPO relative to fat free mass (3.06 W/kg(FFM)).
  
  
  RESULTS
  MPO (W/kg(FFM)) was lower in WC+ than in WC-. Expressed relative to fat mass, leptin was lower and QUICKI higher in WC- than in WC+. In WC+H, leptin and QUICKI were significantly less disturbed than in WC+L and were independently correlated to MPO (r = -0.36 and r = 0.32 respectively; p < 0.001). In WC+, when visceral perimeter was added to the analysis, the relationships MPO/leptin remained significant but not MPO/QUICKI.
  
  
  CONCLUSIONS
  The low PF in subjects with abdominal obesity is independently linked to plasma leptin and insulin sensitivity even if leptin and insulin may share common pathways in their peripheral effects. Visceral adiposity participates to the link between MPO and QUICKI, but not between MPO and leptin.
authors.affiliation: Laboratoire de Physiologie de l'Exercice, EA 4338, Université de Lyon, Saint-Etienne, France.
authors.forename: Mohamed Ali
authors.initials: MA
authors.lastname: Saafi
authors.forename: Delphine
authors.initials: D
authors.lastname: Frere-Meunier
authors.forename: Léonard
authors.initials: L
authors.lastname: Feasson
authors.forename: Nadia
authors.initials: N
authors.lastname: Boutahar
authors.forename: Christian
authors.initials: C
authors.lastname: Denis
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D050154:Adiposity; D001825:Body Fluid Compartments; D016022:Case-Control Studies; D006801:Humans; D007333:Insulin Resistance; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength; D056128:Obesity, Abdominal / Q000097:blood*; D010809:Physical Fitness / Q000502:physiology*; D055105:Waist Circumference
chemical_list: D020738:Leptin