title: Plasma melatonin and urinary 6-hydroxymelatonin levels in patients with pulmonary tuberculosis.
abstract: Tuberculosis (TB) is the second most frequent cause of death in the world, after AIDS. Delay in diagnosing TB is an important worldwide problem. It seriously threatens public health. Cell-mediated immune responses play an important role in the pathogenesis of TB infection. The course of Mycobacterium tuberculosis (MTb) infection is regulated by two distinct T cell cytokine patterns. Melatonin is a biomolecule (mainly secreted by the pineal gland) with free radical scavenging, antioxidant and immunoregulatory properties. Melatonin has both its direct and indirect immunomodulatory effects on the immune system. In this study, we measured plasma melatonin and urine 6-hydroxy melatonin sulphate (6-HMS) concentrations in patients with newly diagnosed TB for the purpose of investigating whether there was a relationship between their levels and MTb infection. Thirty-one newly diagnosed patients presenting with active TB and 31 healthy subjects as the control group were included in this study. Blood and 24-h urine samples were collected from all individuals. Plasma melatonin levels and urine 6-HMS were measured. Our results show that in patients with TB, mean melatonin and 6-HMS concentrations were significantly lower than in the control subjects (p = 0.037, p < 0.001, respectively). We believe that the treatment of TB patients with melatonin might result in a wide range of health benefits including improved quality of life and reduced severity of infection in these patients. Supplementation with melatonin may be considered as an adjunctive therapy to classic treatment of pulmonary TB, especially during the acute phase of infection.
authors.affiliation: Biochemistry Department, Etlik Training and Research Hospital, Ankara, Turkey.
authors.forename: Esin
authors.initials: E
authors.lastname: Ozkan
authors.forename: Halil
authors.initials: H
authors.lastname: Yaman
authors.forename: Erdinc
authors.initials: E
authors.lastname: Cakir
authors.forename: Omer
authors.initials: O
authors.lastname: Deniz
authors.forename: Muzaffer
authors.initials: M
authors.lastname: Oztosun
authors.forename: Seyfettin
authors.initials: S
authors.lastname: Gumus
authors.forename: Emin Ozgur
authors.initials: EO
authors.lastname: Akgul
authors.forename: Mehmet
authors.initials: M
authors.lastname: Agilli
authors.forename: Tuncer
authors.initials: T
authors.lastname: Cayci
authors.forename: Yasemin Gulcan
authors.initials: YG
authors.lastname: Kurt
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Aydin
authors.forename: Yakup
authors.initials: Y
authors.lastname: Arslan
authors.forename: Nevin
authors.initials: N
authors.lastname: Ilhan
authors.forename: Necip
authors.initials: N
authors.lastname: Ilhan
authors.forename: Mehmet Kemal
authors.initials: MK
authors.lastname: Erbil
mesh_terms: D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008550:Melatonin / Q000031:analogs & derivatives* / Q000097:blood* / Q000652:urine; D014397:Tuberculosis, Pulmonary / Q000097:blood* / Q000175:diagnosis / Q000652:urine*; D055815:Young Adult
chemical_list: D008550:Melatonin; C012365:6-hydroxymelatonin