title: A comparative study of phytochemical composition of genetically and non-genetically modified soybean (Glycine max L.) and evaluation of antitumor activity.
abstract: Colon cancer is one of the major causes of cancer mortality worldwide. The analysed feeds, containing non-genetically modified (GM) soybean and Roundup Ready soybean, showed a different polyphenolic content and lipophilic composition. Non-GM soybean extract possessed twice the polyphenolic content of GM soybean and the highest number of sterols. Among them, γ-sitosterol was found to be the major constituent. Methanolic extract of non-GM soybean extract was more potent than GM soybean extract against colon carcinoma cell line LoVo using MTT assay, while the second one showed a slightly higher anti-inflammatory activity. The findings add to epidemiological evidence for the therapeutic effects of soy foods in colorectal carcinoma.
authors.affiliation: Department of Pharmaceutical Sciences, Faculty of Pharmacy, Nutrition and Health Sciences, University of Calabria, I-87036 Arcavacata di Rende (CS), Italy.
authors.forename: Mariangela
authors.initials: M
authors.lastname: Marrelli
authors.forename: Raffaella
authors.initials: R
authors.lastname: Tudisco
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Mastellone
authors.forename: Filomena
authors.initials: F
authors.lastname: Conforti
mesh_terms: D000818:Animals; D002460:Cell Line; D015179:Colorectal Neoplasms / Q000178:diet therapy; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D051379:Mice; D009589:Nitrogen Oxides / Q000378:metabolism; D010636:Phenols / Q000737:chemistry; D010840:Phytosterols / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry* / Q000627:therapeutic use*; D030821:Plants, Genetically Modified / Q000737:chemistry*; D013025:Glycine max / Q000737:chemistry*
chemical_list: D009589:Nitrogen Oxides; D010636:Phenols; D010840:Phytosterols; D010936:Plant Extracts