title: Haploidentical bone marrow transplantation in Mexico.
abstract: Haploidentical hematopoietic cell transplantation using CD34(+) cells depleted of T lymphocytes by the CliniMACS is a treatment for hematological malignancy. We report on four Mexican children, three with acute lymphocytic leukemia and one with chronic myelocytic leukemia, who was transplanted with 12 × 10(6) CD34(+) stem cells/kg body weight (98% of purity) with a follow-up of 9½ years. The engraftment was successful in three of the four children. All showed cytomegalovirus reactivation, and one died because of graft rejection and infectious complication. The risk of infections was a major problem.
authors.affiliation: Banco de Sangre, Hospital General de Ecatepec, Las Americas, Ecatepec Estado de México, Mexico.
authors.forename: José Eugenio
authors.initials: JE
authors.lastname: Vázquez-Meraz
authors.forename: José
authors.initials: J
authors.lastname: Arellano-Galindo
authors.forename: Emma
authors.initials: E
authors.lastname: Mendoza-García
authors.forename: Elva
authors.initials: E
authors.lastname: Jiménez-Hernández
authors.forename: Armando
authors.initials: A
authors.lastname: Martínez Avalos
authors.forename: Norma
authors.initials: N
authors.lastname: Velázquez Guadarrama
authors.forename: Juan Manuel
authors.initials: JM
authors.lastname: Mejía Arangure
mesh_terms: D000293:Adolescent; D016026:Bone Marrow Transplantation; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection; D006085:Graft Survival; D018380:Hematopoietic Stem Cell Transplantation; D006650:Histocompatibility Testing; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000628:therapy*; D008297:Male; D008800:Mexico; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy*; D014184:Transplantation, Homologous