title: [Behavioral effects of ketanserine in prenatally stressed female rats].
abstract: Comparative study of the effects of chronic administration of 5-HT(2A/2C)-receptors agonist (m-CPP, 0.5 mg/kg, i.p.) and 5-HT(2A/2C)-receptors antagonist (ketanserine, 0.1 mg/kg, i.p.) for 14 days on the anxiety- and depression-like behavior in adult prenatally stressed female rats showed that prenatal stress increased the anxiety level in female rats. Chronic administration of ketanserine produced anxiolytic and antidepressant effects, which inhibited the negative action of prenatal stress on the emotional behavior, whereas chronic administration of m-CPP did not change the emotional behavior.
authors.forename: Iu O
authors.initials: IuO
authors.lastname: Fedotova
authors.forename: S G
authors.initials: SG
authors.lastname: Pivina
authors.forename: N E
authors.initials: NE
authors.lastname: Ordian
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D000928:Antidepressive Agents / Q000494:pharmacology*; D001007:Anxiety / Q000209:etiology / Q000503:physiopathology*; D001522:Behavior, Animal / Q000187:drug effects*; D003863:Depression / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D007650:Ketanserin / Q000494:pharmacology*; D018782:Maze Learning / Q000187:drug effects; D010879:Piperazines / Q000008:administration & dosage; D011247:Pregnancy; D051381:Rats; D044402:Receptor, Serotonin, 5-HT2A / Q000378:metabolism; D044405:Receptor, Serotonin, 5-HT2C / Q000378:metabolism; D012702:Serotonin Antagonists / Q000494:pharmacology*; D017366:Serotonin Receptor Agonists / Q000008:administration & dosage; D013315:Stress, Psychological / Q000150:complications / Q000503:physiopathology
chemical_list: D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D010879:Piperazines; D044402:Receptor, Serotonin, 5-HT2A; D044405:Receptor, Serotonin, 5-HT2C; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; D007650:Ketanserin; C015068:1-(3-chlorophenyl)piperazine