title: Sudachitin, a polymethoxyflavone from Citrus sudachi, suppresses lipopolysaccharide-induced inflammatory responses in mouse macrophage-like RAW264 cells.
abstract: Although some polymethoxyflavones possess several important biological properties, including neuroprotective, anticancer, and anti-inflammatory ones, sudachitin, a polymethoxyflavone from Citrus sudachi, has been little studied. In this study, we found that sudachitin inhibited nitric oxide production by suppressing the expression of inducible nitric oxide synthase in lipopolysaccharide-stimulated macrophages, indicating that sudachitin has an anti-inflammatory effect.
authors.affiliation: Department of Biological Science and Technology, The University of Tokushima Graduate School, Tokushima, Japan. yuasa@bio.tokushima-u.ac.jp
authors.forename: Keizo
authors.initials: K
authors.lastname: Yuasa
authors.forename: Kaori
authors.initials: K
authors.lastname: Tada
authors.forename: Genki
authors.initials: G
authors.lastname: Harita
authors.forename: Tomomi
authors.initials: T
authors.lastname: Fujimoto
authors.forename: Masao
authors.initials: M
authors.lastname: Tsukayama
authors.forename: Akihiko
authors.initials: A
authors.lastname: Tsuji
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D002460:Cell Line; D002957:Citrus / Q000737:chemistry*; D054677:Cyclic Nucleotide Phosphodiesterases, Type 1 / Q000037:antagonists & inhibitors; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4 / Q000378:metabolism; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D006027:Glycosides / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects*; D051379:Mice; D058988:Phosphodiesterase 4 Inhibitors / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005419:Flavonoids; D006027:Glycosides; D008070:Lipopolysaccharides; D058988:Phosphodiesterase 4 Inhibitors; C513626:sudachitin; D054677:Cyclic Nucleotide Phosphodiesterases, Type 1; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4