title: Efficient functional delivery of siRNA using mesoporous silica nanoparticles with ultralarge pores.
abstract: Among various nanoparticles, mesoporous silica nanoparticles (MSNs) have attracted extensive attention for developing efficient drug-delivery systems, mostly due to their high porosity and biocompatibility. However, due to the small pore size, generally below 5 nm in diameter, potential drugs that are loaded into the pore have been limited to small molecules. Herein, a small interfering RNA (siRNA) delivery strategy based on MSNs possessing pores with an average diameter of 23 nm is presented. The siRNA is regarded as a powerful gene therapeutic agent for treatment of a wide range of diseases by enabling post-transcriptional gene silencing, so-called RNA interference. Highly efficient, sequence-specific, and technically very simple target gene knockdown is demonstrated using MSNs with ultralarge pores of size 23 nm in vitro and in vivo without notable cytotoxicity.
authors.affiliation: Department of Chemistry, Korea Advanced Institute of Science and Technology, Daejeon, Korea.
authors.forename: Hee-Kyung
authors.initials: HK
authors.lastname: Na
authors.forename: Mi-Hee
authors.initials: MH
authors.lastname: Kim
authors.forename: Kihyun
authors.initials: K
authors.lastname: Park
authors.forename: Soo-Ryoon
authors.initials: SR
authors.lastname: Ryoo
authors.forename: Kyung Eun
authors.initials: KE
authors.lastname: Lee
authors.forename: Hyesung
authors.initials: H
authors.lastname: Jeon
authors.forename: Ryong
authors.initials: R
authors.lastname: Ryoo
authors.forename: Changbong
authors.initials: C
authors.lastname: Hyeon
authors.forename: Dal-Hee
authors.initials: DH
authors.lastname: Min
mesh_terms: D053758:Nanoparticles / Q000737:chemistry*; D016062:Porosity; D034741:RNA, Small Interfering / Q000008:administration & dosage* / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry*; D013696:Temperature
chemical_list: D034741:RNA, Small Interfering; D012822:Silicon Dioxide