title: Carotenoid composition and in vitro pharmacological activity of rose hips.
abstract: The aim of the present study was to compare carotenoid extracts of Rose hips (Rosa canina L.) with regard to their phytochemical profiles and their in vitro anti-Helicobacter pylori (H. pylori), cytotoxic, multidrug resistance (MDR) reversal and radical scavenging activity. Carotenoid composition was investigated in the different fractionation of rose hips, using extraction methods. Six main carotenoids - epimers of neochrome, lutein, zeaxanthin, rubixanthin, lycopene, β,β-carotene - were identified from Rose hips by their chromatographic behavior and UV-visible spectra, which is in accordance with other studies on carotenoids in this plant material. The active principles in the carotenoid extract might differ, depending upon the extraction procedures.
authors.affiliation: Department of Pharmacognosy, University of Pécs, Medical School, Hungary. gyorgyi.horvath@aok.pte.hu
authors.forename: Györgyi
authors.initials: G
authors.lastname: Horváth
authors.forename: Péter
authors.initials: P
authors.lastname: Molnár
authors.forename: Erika
authors.initials: E
authors.lastname: Radó-Turcsi
authors.forename: József
authors.initials: J
authors.lastname: Deli
authors.forename: Masami
authors.initials: M
authors.lastname: Kawase
authors.forename: Kazue
authors.initials: K
authors.lastname: Satoh
authors.forename: Toru
authors.initials: T
authors.lastname: Tanaka
authors.forename: Satoru
authors.initials: S
authors.lastname: Tani
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Sakagami
authors.forename: Nóra
authors.initials: N
authors.lastname: Gyémánt
authors.forename: József
authors.initials: J
authors.lastname: Molnár
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000737:chemistry; D002338:Carotenoids / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D014975:Lutein / Q000737:chemistry / Q000494:pharmacology; D000077276:Lycopene; D010851:Picrates / Q000737:chemistry; D027826:Rosa / Q000737:chemistry*; D024341:Xanthophylls / Q000737:chemistry / Q000494:pharmacology; D065146:Zeaxanthins; D019207:beta Carotene / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D001713:Biphenyl Compounds; D010851:Picrates; D024341:Xanthophylls; D065146:Zeaxanthins; C492072:neochrome; D019207:beta Carotene; D002338:Carotenoids; C004931:1,1-diphenyl-2-picrylhydrazyl; D000077276:Lycopene; D014975:Lutein