title: The application of genomic and molecular data in the treatment of chronic cancer pain.
abstract: Many cancer patients will develop complex pain syndromes requiring aggressive, innovative, and comprehensive multimodal pain management strategies. Recently, data from both animal studies and clinical trials have allowed clinical research to focus on creating applicable clinical treatment strategies. This article is a review of genomic and molecular data, which has contributed to creating novel modalities for use in clinical pain management of patients with cancer-induced pain.
authors.affiliation: Defense & Veterans Pain Management Initiative, Anesthesia & Operative Service, Walter Reed Army Medical Center, Washington, District of Columbia 20307, USA.
authors.forename: Ali
authors.initials: A
authors.lastname: Turabi
authors.forename: Anthony R
authors.initials: AR
authors.lastname: Plunkett
mesh_terms: D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000927:Anticonvulsants / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001340:Autonomic Nerve Block; D002394:Catechol O-Methyltransferase / Q000235:genetics; D002908:Chronic Disease; D015316:Genetic Therapy / Q000379:methods* / Q000639:trends; D006801:Humans; D016202:N-Methylaspartate / Q000037:antagonists & inhibitors; D009369:Neoplasms / Q000150:complications* / Q000188:drug therapy; D010146:Pain / Q000139:chemically induced / Q000209:etiology* / Q000235:genetics / Q000503:physiopathology*; D059408:Pain Management / Q000379:methods*; D020641:Polymorphism, Single Nucleotide / Q000187:drug effects; D017450:Receptors, Opioid, mu / Q000235:genetics; D013003:Somatosensory Cortex / Q000187:drug effects; D057170:Translational Research, Biomedical / Q000639:trends
chemical_list: D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000927:Anticonvulsants; D000928:Antidepressive Agents; D000970:Antineoplastic Agents; C485764:OPRM1 protein, human; D017450:Receptors, Opioid, mu; D016202:N-Methylaspartate; D002394:Catechol O-Methyltransferase