title: Incidence of acute exacerbation of interstitial pneumonia in operated lung cancer: institutional report and review.
abstract: OBJECTIVE
  Several small studies have reported that acute exacerbation (AE) of idiopathic interstitial pneumonia (IIP) can occur after lung resection for patients with non-small cell lung cancer, though the incidence rate is unclear.
  
  
  METHODS
  We examined our institutional data and performed a search of the MEDLINE database for publications regarding AE of IIP following surgery for lung cancer. Studies reporting the incidence rates of IIP and AE were included.
  
  
  RESULTS
  Eleven studies including our institutional data were determined to be eligible. Seven studies designated the incidence of IIP. Of 4749 patients (from 7 studies) who underwent lung resection for NSCLC, 277 had IIP, for an incidence rate of 5.8% (range 1.1%-11.7%). Eleven studies designated the incidence of AE from IIP patient, 67 (15.8%) of 424 IIP patients (from 11 studies) developed AE after surgery, of whom 38 (56.7%) died during the postoperative course.
  
  
  CONCLUSIONS
  Coexistent IIP in patients with lung cancer increases the risk of lung cancer surgery. Furthermore, AE of IIP may be a major cause of operation-related death.
authors.affiliation: Department of General Thoracic Surgery, Dokkyo Medical University, Shimotsuga, Tochigi, Japan. chida-ths@umin.ac.jp
authors.forename: Masayuki
authors.initials: M
authors.lastname: Chida
authors.forename: Satoru
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Yoko
authors.initials: Y
authors.lastname: Karube
authors.forename: Makio
authors.initials: M
authors.lastname: Hayama
authors.forename: Motohiko
authors.initials: M
authors.lastname: Tamura
authors.forename: Hiromi
authors.initials: H
authors.lastname: Ishihama
authors.forename: Takeshi
authors.initials: T
authors.lastname: Oyaizu
mesh_terms: D000208:Acute Disease; D002289:Carcinoma, Non-Small-Cell Lung / Q000453:epidemiology / Q000401:mortality / Q000601:surgery*; D015897:Comorbidity; D018450:Disease Progression; D006801:Humans; D054988:Idiopathic Interstitial Pneumonias / Q000453:epidemiology* / Q000401:mortality; D054990:Idiopathic Pulmonary Fibrosis / Q000453:epidemiology; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008175:Lung Neoplasms / Q000453:epidemiology / Q000401:mortality / Q000601:surgery*; D011013:Pneumonectomy / Q000009:adverse effects* / Q000401:mortality; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome