title: Body temperature modulates the antioxidant and acute immune responses to exercise.
abstract: The aim of this study was to determine the effects of whole body heat in combination with exercise on the oxidative stress and acute phase immune response. Nine male endurance-trained athletes voluntarily performed two running bouts of 45 minutes at 75-80% of VO(2max) in a climatic chamber in two conditions: cold and hot humid environment. Leukocyte, neutrophil and basophil counts significantly rose after exercise in both environments; it was significantly greater in the hot environment. Lymphocyte and neutrophil antioxidant enzyme activities and carbonyl index significantly increased or decreased after exercise only in the hot environment, respectively. The lymphocytes expression of catalase, Hsp72 and CuZn-superoxide dismutase was increased in the hot environment and Sirt3 in the cold environment, mainly during recovery. In conclusion, the increased core body temperature results in the acute phase immune response associated to intense exercise and in the immune cell adaptations to counteract the oxidative stress situation.
authors.affiliation: Laboratory of Physical Activity Science, Department of Fundamental Biology and Health Sciences, University of the Balearic Islands, Palma de Mallorca, Spain.
authors.forename: Antonia
authors.initials: A
authors.lastname: Mestre-Alfaro
authors.forename: Miguel D
authors.initials: MD
authors.lastname: Ferrer
authors.forename: Montserrat
authors.initials: M
authors.lastname: Banquells
authors.forename: Joan
authors.initials: J
authors.lastname: Riera
authors.forename: Franchek
authors.initials: F
authors.lastname: Drobnic
authors.forename: Antoni
authors.initials: A
authors.lastname: Sureda
authors.forename: Josep A
authors.initials: JA
authors.lastname: Tur
authors.forename: Antoni
authors.initials: A
authors.lastname: Pons
mesh_terms: D000210:Acute-Phase Reaction / Q000276:immunology*; D000222:Adaptation, Physiological; D000975:Antioxidants / Q000378:metabolism*; D001831:Body Temperature / Q000276:immunology*; D018592:Cross-Over Studies; D015444:Exercise / Q000502:physiology*; D006801:Humans; D008297:Male; D018375:Neutrophil Activation / Q000276:immunology; D018384:Oxidative Stress / Q000276:immunology; D010807:Physical Endurance / Q000276:immunology*; D012420:Running; D013177:Sports
chemical_list: D000975:Antioxidants