title: Expression of β-tubulin isotypes in classical Hodgkin's lymphoma.
abstract: Microtubules consist of heterodimers of α- and β-tubulin. Aberrant expression of specific β-tubulin isotype is associated with resistance to chemotherapy in malignant tumors. In this study, we examined the expressions of β-tubulin isotypes in classical Hodgkin's lymphoma (cHL) by immunohistochemistry. Among the β-tubulin isotypes, class II β-tubulin (31/34, 91%) was most frequently overexpressed in the cytoplasm of almost all Hodgkin's and Reed-Sternberg (HRS) cells, followed by class I β-tubulin (18/34, 53%) and class III β-tubulin (12/34, 35%). Class IV β-tubulin was not expressed in any cHL case. Class I β-tubulin was expressed in the background lymphoid cells as well as the HRS cells. Thus, our results indicate that class II β-tubulin may be very useful for immunohistochemical diagnosis of cHL, and provide valuable information for the potential application of β-tubulin isotype-specific targeting.
authors.affiliation: Department of Pathology, Korea University Ansan Hospital, Ansan, Korea.
authors.forename: Jung-Woo
authors.initials: JW
authors.lastname: Choi
authors.forename: Ju-Han
authors.initials: JH
authors.lastname: Lee
authors.forename: Young-Sik
authors.initials: YS
authors.lastname: Kim
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism; D002648:Child; D005260:Female; D006689:Hodgkin Disease / Q000175:diagnosis / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008297:Male; D008875:Middle Aged; D020033:Protein Isoforms; D016539:Reed-Sternberg Cells / Q000378:metabolism / Q000473:pathology; D014404:Tubulin / Q000378:metabolism*; D055815:Young Adult
chemical_list: D014408:Biomarkers, Tumor; D020033:Protein Isoforms; D014404:Tubulin