title: [Studies on the antidiabetic effect of konjac glucomannan with different molecular chains on experimental diabetes mice].
abstract: The antidiabetic effect of konjac glucomannan with different molecular chains on experimental diabetes mice was studied. The result showed that KGM- I, KGM-II, KGM-III and konjac flour can lower blood sugar of alloxan-induced hyperglycemic mice. When the dose was 1.5 g/kg, the decrease rates of blood sugar was 55.37%, 80.60%, 33.44% and 40.9%, respectively. It also showed that KGM-II (Po, 0.2 g/kg. d x 7d) can significantly intensify DTH induced by DNFB and improve phagocytosing function of peritoneal macrophage (PM phi) separetely.
authors.affiliation: Department of Food Science and Technology, Huazhong Agriculture University, Wuhan 430070.
authors.forename: Chunmei
authors.initials: C
authors.lastname: Li
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Wang
authors.forename: Wei
authors.initials: W
authors.lastname: He
authors.forename: Bijun
authors.initials: B
authors.lastname: Xie
mesh_terms: D000496:Alloxan / Q000008:administration & dosage; D031056:Amorphophallus / Q000737:chemistry*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006968:Hypersensitivity, Delayed / Q000139:chemically induced / Q000473:pathology; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology*; D017737:Macrophages, Peritoneal / Q000187:drug effects; D008297:Male; D008351:Mannans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D008970:Molecular Weight; D010587:Phagocytosis / Q000187:drug effects; D011208:Powders
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D008351:Mannans; D011208:Powders; C022901:(1-6)-alpha-glucomannan; D000496:Alloxan