title: Polyaspartamide-polylactide electrospun scaffolds for potential topical release of Ibuprofen.
abstract: In this work, the production and characterization of electrospun scaffolds of the copolymer α,β-poly(N-2-hydroxyethyl)-DL-aspartamide-graft-polylactic acid (PHEA-g-PLA), proposed for a potential topical release of Ibuprofen (IBU), are reported. The drug has been chemically linked to PHEA-g-PLA and/or physically mixed to the copolymer before electrospinning. Degradation studies have been performed as a function of time in Dulbecco phosphate buffer solution pH 7.4, for both unloaded and drug-loaded scaffolds. By using an appropriate ratio between drug physically blended to the copolymer and drug-copolymer conjugate, a useful control of its release can be obtained. MTS assay on human dermal fibroblasts cultured onto these scaffolds, showed the absence of toxicity as well as their ability to allow cell adhesion.
authors.affiliation: Dipartimento di Scienze e Tecnologie Molecolari e Biomolecolari, Sezione di Chimica e Tecnologie Farmaceutiche, Università degli Studi di Palermo, Via Archirafi 32, 90123, Palermo, Italy. giovanna.pitarresi@unipa.it
authors.forename: G
authors.initials: G
authors.lastname: Pitarresi
authors.forename: C
authors.initials: C
authors.lastname: Fiorica
authors.forename: F S
authors.initials: FS
authors.lastname: Palumbo
authors.forename: F
authors.initials: F
authors.lastname: Calascibetta
authors.forename: G
authors.initials: G
authors.lastname: Giammona
mesh_terms: D000287:Administration, Topical; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage*; D001224:Aspartic Acid / Q000031:analogs & derivatives*; D001672:Biocompatible Materials / Q000737:chemistry; D002448:Cell Adhesion; D002460:Cell Line; D002470:Cell Survival; D020405:Dermis / Q000166:cytology; D004337:Drug Carriers / Q000737:chemistry*; D005347:Fibroblasts / Q000166:cytology; D006801:Humans; D007052:Ibuprofen / Q000008:administration & dosage*; D011091:Polyesters / Q000737:chemistry*; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D018712:Analgesics, Non-Narcotic; D001672:Biocompatible Materials; D004337:Drug Carriers; D011091:Polyesters; D001224:Aspartic Acid; C033616:poly(lactide); D007052:Ibuprofen