title: A catalytic asymmetric reaction involving enolizable anhydrides.
abstract: In the presence of a highly efficient novel bifunctional organocatalyst at low loadings under mild conditions, enolizable homophthalic anhydrides can be added to a range of aromatic and aliphatic aldehydes to give dihydroisocoumarins, with excellent yields and diastereo- and enantiocontrol (up to 99% ee).
authors.affiliation: Centre for Synthesis and Chemical Biology, Trinity Biomedical Sciences Institute, School of Chemistry, The University of Dublin, Trinity College, Dublin 2, Ireland.
authors.forename: Claudio
authors.initials: C
authors.lastname: Cornaggia
authors.forename: Francesco
authors.initials: F
authors.lastname: Manoni
authors.forename: Esther
authors.initials: E
authors.lastname: Torrente
authors.forename: Sean
authors.initials: S
authors.lastname: Tallon
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Connon
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D000812:Anhydrides / Q000737:chemistry*; D002384:Catalysis; D002930:Cinchona Alkaloids / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D049934:Isocoumarins / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D000812:Anhydrides; D002930:Cinchona Alkaloids; D049934:Isocoumarins