title: Assessment of induction, recovery, agitation upon awakening, and consumption with the use of two brands of sevoflurane for ambulatory anesthesia.
abstract: OBJECTIVE
  Due to its pharmacological characteristics, sevoflurane is the ideal anesthetic for short-duration procedures. There are two brands of sevoflurane in the Brazilian market, Sevocris® and Sevorane®, with different formulations and packaging. The objective of this study was to assess whether there are differences between the two anesthetics regarding induction, maintenance, recovery, and consumption.
  
  
  METHODS
  One hundred and thirty children were included, divided into two groups according to the brand used: Group 1 was assigned to sevoflurane Cristália® and Group 2 to sevoflurane Abbott®. The following parameters were assessed: heart rate, systolic and diastolic blood pressure, fraction of inspired and expired sevoflurane, BIS values, tympanic temperature, induction and recovery time, agitation upon awakening measured by the PAED scale, and anesthetic consumption by weighing the vaporizers. Anesthesia was induced with 1 MAC and increased every three breaths at 0.5 MAC, up to 3 MAC.
  
  
  RESULTS
  There was no difference between groups regarding the duration of the procedure, the anesthesia, and the parameters evaluated at induction. In Group 1, the number of children who required additional bolus of sevoflurane for anesthesia maintenance was higher than in Group 2 (p<0.05). The fraction of inspired and expired sevoflurane at the end of the procedure was lower in Group 1 (p<0.001). Upon awakening, BIS value was lower in Group 1 (p=0.045). Other parameters evaluated in recovery showed no difference between groups. The use of anesthesia was similar between groups.
authors.affiliation: Anesthesiology, Pain, and Intensive-care Medicine Course, UniversidadeFederal de São Paulo, SP, Brazil.
authors.forename: Cíntia Reina Grisan
authors.initials: CR
authors.lastname: Tomal
authors.forename: Ana Gabriela Padua Dias da
authors.initials: AG
authors.lastname: Silva
authors.forename: Américo Massafuni
authors.initials: AM
authors.lastname: Yamashita
authors.forename: Pamela Vieira de
authors.initials: PV
authors.lastname: Andrade
authors.forename: Márcia Tamiko
authors.initials: MT
authors.lastname: Hirano
authors.forename: Maria Angela
authors.initials: MA
authors.lastname: Tardelli
authors.forename: Helga Cristina Almeida
authors.initials: HC
authors.lastname: Silva
mesh_terms: D017109:Akathisia, Drug-Induced / Q000209:etiology; D000556:Ambulatory Surgical Procedures; D000758:Anesthesia; D000762:Anesthesia Recovery Period; D018685:Anesthetics, Inhalation / Q000008:administration & dosage* / Q000009:adverse effects; D002626:Chemistry, Pharmaceutical; D002675:Child, Preschool; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008738:Methyl Ethers / Q000008:administration & dosage* / Q000009:adverse effects; D011595:Psychomotor Agitation; D000077149:Sevoflurane
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane