title: [Dysport in the treatment of essential tremor].
abstract: Head tremor develops in one-third of patients with essential tremor. It is resistant to peroral antitremor medications. The efficacy of dysport, a botulinum toxin type A preparation, injected in the neck muscles, was examined in 12 patients with head tremor. After the injection of 500 U of the drug (150 U in each splenius muscle of the head and 100 U in each sternal-clavicular-mammiform muscle), the intensity of head tremor assessed by the rating tremor scale was decreased by more than 50%. The clinically significant effect was registrated in more than 2/3 of patients. Five patients who received repeated injections of dysport 2 times a year were followed-up for 3 years that allowed to find a trend towards the slow cumulative effect. The use of botulinum toxin type A preparations is recommended as a method of choice in patients with essential tremor and significant head tremor interfering with life activities.
authors.forename: O S
authors.initials: OS
authors.lastname: Levin
authors.forename: S V
authors.initials: SV
authors.lastname: Vasechkin
mesh_terms: D000328:Adult; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage / Q000627:therapeutic use*; D020329:Essential Tremor / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged
chemical_list: D019274:Botulinum Toxins, Type A; C542869:abobotulinumtoxinA