title: Persistent neurological deficit from iodinated contrast encephalopathy following intracranial aneurysm coiling. A case report and review of the literature.
abstract: Neurotoxicity from iodinated contrast agents is a known but rare complication of angiography and neurovascular intervention. Neurotoxicity results from contrast penetrating the blood-brain barrier with resultant cerebral oedema and altered neuronal excitability. Clinical effects include encephalopathy, seizures, cortical blindness and focal neurological deficits. Contrast induced encephalopathy is extensively reported as a transient and reversible phenomenon. We describe a patient with a persistent motor deficit due to an encephalopathy from iodinated contrast media administered during cerebral aneurysm coiling. This observation and a review of the literature highlights that contrast-induced encephalopathy may not always have a benign outcome and can cause permanent deficits. This potential harmful effect should be recognised by the angiographer and the interventionalist.
authors.affiliation: Department of Radiology, Cork University Hospital, Ireland. leong81@gmail.com
authors.forename: S
authors.initials: S
authors.lastname: Leong
authors.forename: N F
authors.initials: NF
authors.lastname: Fanning
mesh_terms: D002533:Cerebral Angiography / Q000009:adverse effects*; D003287:Contrast Media / Q000009:adverse effects*; D004621:Embolization, Therapeutic; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging* / Q000628:therapy*; D007457:Iodine Radioisotopes / Q000009:adverse effects; D008875:Middle Aged; D020258:Neurotoxicity Syndromes / Q000209:etiology*; D014057:Tomography, X-Ray Computed / Q000009:adverse effects
chemical_list: D003287:Contrast Media; D007457:Iodine Radioisotopes