title: Elevated serum adipocyte fatty acid-binding protein concentrations are independently associated with renal dysfunction in patients with stable angina pectoris.
abstract: BACKGROUND
  Chronic kidney disease (CKD) is associated with cardiovascular events. Adipocyte fatty acid-binding protein (A-FABP) plays an important role in atherosclerosis. We investigated whether plasma A-FABP is involved in renal function in patients with stable angina pectoris.
  
  
  METHODS
  A total of 221 patients with significant coronary artery stenosis were enrolled after coronary angiography. CKD was defined as an estimated glomerular filtration rate (eGFR) < 60 ml/min/1.73 m2. The severity of coronary stenosis was assessed using a modified Gensini score and coronary angiography. Serum A-FABP levels were determined by enzyme-linked immunosorbent assay.
  
  
  RESULTS
  Serum A-FABP levels were significantly correlated with both eGFR (r = -0.41, p < 0.01) and the severity of coronary artery stenosis (r = 0.16, p = 0.02), and these relationships remained significant after adjusting for confounding factors. The prevalence of CKD and multi-vessel disease was significantly higher among patients with serum A-FABP levels above the median value of 20.3 ng/ml than among patients with serum A-FABP levels below the median value (57% vs. 27%, p < 0.01 and 64% vs. 48%, p = 0.02, respectively). Multivariate analysis revealed that the presence of three-vessel disease in comparison with single-vessel disease was independently associated with the higher A-FABP (per doubling) (odds ratio; 2.26, 95% confidential interval; 1.28-3.98, p < 0.01) and tended to be associated with the lower eGFR (p = 0.06).
  
  
  CONCLUSIONS
  Serum A-FABP may have a significant role in the interplay between renal dysfunction and coronary atherosclerosis.
authors.affiliation: Department of Cardiology, Kagawa Prefectural Central Hospital, Kagawa, Japan.
authors.forename: Mutsumi
authors.initials: M
authors.lastname: Iwamoto
authors.forename: Toru
authors.initials: T
authors.lastname: Miyoshi
authors.forename: Masayuki
authors.initials: M
authors.lastname: Doi
authors.forename: Ko
authors.initials: K
authors.lastname: Takeda
authors.forename: Masahito
authors.initials: M
authors.lastname: Kajiya
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Nosaka
authors.forename: Rie
authors.initials: R
authors.lastname: Nakayama
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hirohata
authors.forename: Shinichi
authors.initials: S
authors.lastname: Usui
authors.forename: Shozo
authors.initials: S
authors.lastname: Kusachi
authors.forename: Kosuke
authors.initials: K
authors.lastname: Sakane
authors.forename: Kazuhfumi
authors.initials: K
authors.lastname: Nakamura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ito
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D060050:Angina, Stable / Q000150:complications* / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000150:complications* / Q000503:physiopathology; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005919:Glomerular Filtration Rate / Q000502:physiology; D006801:Humans; D007674:Kidney Diseases / Q000097:blood* / Q000453:epidemiology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index
chemical_list: D015415:Biomarkers; C493410:FABP4 protein, human; D050556:Fatty Acid-Binding Proteins