title: [Endothelial dysfunction. An integrated overview of the physiopatologic and diagnostic aspects].
abstract: Endothelial dysfunction is an early alteration in the atherosclerotic process. Cardiovascular risk factors induce endothelial dysfunction, characterized by impaired endothelium-dependent vasodilatation and by new proatherogenic, proinflammatory and prothrombotic properties. It is evident as the study of the endothelium could play a key role in the cardiovascular research and can be an useful tool for risk stratification in primary prevention of cardiovascular disease. An ideal approach for the comprehensive evaluation on endothelial physiopathology would take into account and integrate informations about endothelial biology (activation, injury and regenerative capacity) and endothelial function, so to be correlated with clinical data.
authors.affiliation: Istituto di Fisiologia Clinica, Consiglio Nazionale delle Ricerche, Pisa. serena@ifc.cnr.it
authors.forename: Serena
authors.initials: S
authors.lastname: Del Turco
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Bianchini
authors.forename: Rita
authors.initials: R
authors.lastname: Bucalo
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Basta
authors.forename: Rosa Maria
authors.initials: RM
authors.lastname: Bruno
authors.forename: Rosa
authors.initials: R
authors.lastname: Sicari
mesh_terms: D015415:Biomarkers; D002318:Cardiovascular Diseases / Q000175:diagnosis* / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000503:physiopathology*; D006801:Humans
chemical_list: D015415:Biomarkers