title: Effect of the molecular mass of tremella polysaccharides on accelerated recovery from cyclophosphamide-induced leucopenia in rats.
abstract: The body of tremella were decocted with water, and hydrolyzed with 0.1 mol/L hydrochloric acid for different times, giving tremella polysaccharides with six molecular mass values. The structures of all the tremella polysaccharides had non-reducing terminals of β-D-pyranglucuronide, the backbone was composed of (1 → 3)-linked β-D-manno-pyranoside, and the side chain composed of (1 → 6)-linked β-D-xylopyranoside was attached to the C(2) of the backbone mannopyranoside. Immunomodulatory effect studies indicated that tremella polysaccharides increased the counts of leukocytes in the peripheral blood which were significantly lowered by cyclophosphamide, and the lower the molecular mass of the tremella polysaccharide, the better this effect was.
authors.affiliation: Jilin Academy of Chinese Medicine and Material Medica Science, Changchun 130012, Jilin, China. zhongyanjrz@yahoo.com.cn
authors.forename: Rui-Zhi
authors.initials: RZ
authors.lastname: Jiang
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Hao-Ming
authors.initials: HM
authors.lastname: Luo
authors.forename: Yan-Qiu
authors.initials: YQ
authors.lastname: Cheng
authors.forename: Ying-Hong
authors.initials: YH
authors.lastname: Chen
authors.forename: Yang
authors.initials: Y
authors.lastname: Gao
authors.forename: Qi-Pin
authors.initials: QP
authors.lastname: Gao
mesh_terms: D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000633:toxicity*; D001487:Basidiomycota / Q000737:chemistry*; D001854:Bone Marrow Cells / Q000187:drug effects; D003520:Cyclophosphamide / Q000633:toxicity*; D005260:Female; D007958:Leukocyte Count; D007962:Leukocytes / Q000187:drug effects; D007970:Leukopenia / Q000139:chemically induced* / Q000188:drug therapy; D008297:Male; D008745:Methylation; D008970:Molecular Weight; D011134:Polysaccharides / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology; D051381:Rats
chemical_list: D018906:Antineoplastic Agents, Alkylating; D011134:Polysaccharides; D003520:Cyclophosphamide