title: A controlled trial of practolol in mild hypertension.
abstract: 1 Fifteen patients with diastolic blood pressures between 90 and 120 mmHg were admitted to a trial comparing placebo with practolol at doses up to 500 mg 12 hourly. 2 The trial was a double blind cross over study. Treatments were allocated at random and each treatment block lasted 12 weeks. 3 Ten patients completed the trial, and none of those who withdrew experienced serious unwanted effects. 4 Practolol caused significant falls in standing systolic and diastolic pressures and the supine diastolic pressure.
authors.affiliation: The Department of Clinical Pharmacology and Therapeutics, The London Hospital Medical College, Turner Street, London.
authors.forename: D M
authors.initials: DM
authors.lastname: Chaput de Saintonge
authors.forename: C J
authors.initials: CJ
authors.lastname: Roberts
authors.forename: I D
authors.initials: ID
authors.lastname: Strickland
authors.forename: D W
authors.initials: DW
authors.lastname: Vere