title: Behavior and function of tissue-resident memory T cells.
abstract: Our understanding of memory T cell function in mice and men is to date in large part restricted to the behavior of circulating memory T cells. Emerging evidence, however, suggests that in addition to such systemic memory T cell populations, a separate population of locally confined memory T cells is generated at former sites of antigen encounter. Here, we discuss the potential function of these long-term tissue-resident memory T cells (T(TRM)), how such local T cell memory can be maintained for prolonged periods of time, and how the induction of long-term tissue-resident memory T cells may potentially be exploited during vaccination.
authors.affiliation: Division of Immunology, The Netherlands Cancer Institute, Plesmanlaan, Amsterdam, The Netherlands.
authors.forename: Silvia
authors.initials: S
authors.lastname: Ariotti
authors.forename: John B
authors.initials: JB
authors.lastname: Haanen
authors.forename: Ton N
authors.initials: TN
authors.lastname: Schumacher
mesh_terms: D000818:Animals; D005260:Female; D006564:Herpesviridae / Q000276:immunology; D006566:Herpesviridae Infections / Q000276:immunology; D006801:Humans; D007156:Immunologic Memory; D008297:Male; D051379:Mice; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000378:metabolism; D014611:Vaccination; D014612:Vaccines / Q000276:immunology*
chemical_list: D014612:Vaccines