title: Role sympathetic autonomic nervous system in the regulation of immune response during myasthenia.
abstract: In 12 patients with myasthenia, the content of β(2)-adrenoreceptors on the cell surface and activity of intracellular lymphocytic enzymes were determined by EIA and biochemical methods, respectively. In comparison with the normal, these patients demonstrated pronounced elevation in the content of β(2)-adrenoreceptors and significant changes in activity of lymphocytic enzymes. In 10 of 12 patients, administration of the agonists to β(2)-adrenoreceptors resulted in health improvement accompanied by normalization of EMG and immunobiochemical indices. Our findings suggest that intra- and intercellular signaling pathways and their modification can serve as potential targets for the therapy.
authors.affiliation: State Research Institute of General Pathology and Pathological Physiology, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: V B
authors.initials: VB
authors.lastname: Lantsova
authors.forename: E K
authors.initials: EK
authors.lastname: Sepp
authors.forename: A S
authors.initials: AS
authors.lastname: Kozlovsky
mesh_terms: D000293:Adolescent; D058666:Adrenergic beta-2 Receptor Agonists / Q000494:pharmacology; D000328:Adult; D000420:Albuterol / Q000494:pharmacology; D000469:Alkaline Phosphatase / Q000378:metabolism; D002648:Child; D005260:Female; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008214:Lymphocytes / Q000201:enzymology*; D008297:Male; D009157:Myasthenia Gravis / Q000276:immunology*; D018343:Receptors, Adrenergic, beta-2 / Q000502:physiology*; D013564:Sympathetic Nervous System / Q000502:physiology*; D055815:Young Adult; D005723:gamma-Glutamyltransferase / Q000378:metabolism
chemical_list: D058666:Adrenergic beta-2 Receptor Agonists; D018343:Receptors, Adrenergic, beta-2; D007770:L-Lactate Dehydrogenase; D005723:gamma-Glutamyltransferase; D000469:Alkaline Phosphatase; D000420:Albuterol