title: [Determination of the optimal ROI setting position of the input function for the ⁹⁹mTc-ethyl cysteinate dimmer brain uptake ratio method].
abstract: Determination of the input function for the (99m)Tc-ethyl cysteinate dimmer brain uptake ratio ((99m)Tc-ECD BUR) method as a non-invasive quantitative measurement of cerebral blood flow measurement is of critical importance in order to improve the accuracy of this method. The input functions were experimentally obtained by setting the regions of interest (ROIs) in the ascending aorta, aortic arch, and descending aorta on the 49 chest RI-angio images. rCBFs by the BUR method with 3 input functions of the 6 cases were compared with those by the (123)I-iodoamphetamine (IMP) continuous arterial blood sampling method in order to determine the best location for the ROI of the input function. The input function of the ascending aorta was higher than those of the aortic arch and the descending aorta. The input functions of the aortic arch and the descending aorta decreased due to the origin of the three branches of the right brachiocephalic artery, left subclavian artery, and left common carotid artery. A good correlation was found in the regional cerebral blood flow (rCBF) values between the (123)I-IMP continuous arterial blood sampling method and the (99m)Tc-ECD BUR method with the input function of the ascending aorta. Therefore, the ascending aorta is the best location for the ROI of the input function for the (99m)Tc-ECD BUR method.
authors.affiliation: Graduate School of Health Sciences, Kumamoto University.
authors.forename: Shinya
authors.initials: S
authors.lastname: Inoue
authors.forename: Takuma
authors.initials: T
authors.lastname: Kabuto
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Masunaga
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Souma
authors.forename: Akihiro
authors.initials: A
authors.lastname: Takaki
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Hosoya
authors.forename: Katsunori
authors.initials: K
authors.lastname: Yoshioka
authors.forename: Shigeki
authors.initials: S
authors.lastname: Ito
mesh_terms: D000983:Antipyrine / Q000031:analogs & derivatives; D001011:Aorta; D001013:Aorta, Thoracic; D001921:Brain / Q000378:metabolism*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003553:Cystine / Q000031:analogs & derivatives*; D006801:Humans; D008297:Male; D019275:Radiopharmaceuticals; D013667:Technetium; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D019275:Radiopharmaceuticals; C541351:ethyl cysteinate dimer; D003553:Cystine; D013667:Technetium; D000983:Antipyrine; C008135:iodoantipyrine