title: Innovation: Metabolomics: the apogee of the omics trilogy.
abstract: Metabolites, the chemical entities that are transformed during metabolism, provide a functional readout of cellular biochemistry. With emerging technologies in mass spectrometry, thousands of metabolites can now be quantitatively measured from minimal amounts of biological material, which has thereby enabled systems-level analyses. By performing global metabolite profiling, also known as untargeted metabolomics, new discoveries linking cellular pathways to biological mechanism are being revealed and are shaping our understanding of cell biology, physiology and medicine.
authors.affiliation: Department of Chemistry, Washington University School of Medicine, St. Louis, Missouri 63110, USA. gjpattij@wustl.edu
authors.forename: Gary J
authors.initials: GJ
authors.lastname: Patti
authors.forename: Oscar
authors.initials: O
authors.lastname: Yanes
authors.forename: Gary
authors.initials: G
authors.lastname: Siuzdak
mesh_terms: D001669:Biochemical Phenomena; D013058:Mass Spectrometry / Q000379:methods; D055432:Metabolomics / Q000379:methods*