title: Carbon nanotube thin film biosensors for sensitive and reproducible whole virus detection.
abstract: Here, we report the label-free, sensitive, and real-time electrical detection of whole viruses using carbon nanotube thin film (CNT-TF) field effect devices. Selective detection of approximately 550 model viruses, M13-bacteriophage, is demonstrated using a simple two-terminal (no gate electrode) configuration. Chemical gating through specific antibody-virus binding on CNT surface is proposed to be the sensing mechanism. Compared to electrical impedance sensors with identical microelectrode dimensions (no CNT), the CNT-TF sensors exhibit sensitivity 5 orders higher. We believe the reported approach could lead to a reproducible and cost-effective solution for rapid viral identification.
authors.affiliation: Department of Chemistry, University of Waterloo, 200 University Avenue West, Waterloo, Ontario, N2L 3G1, Canada.
authors.forename: Himadri S
authors.initials: HS
authors.lastname: Mandal
authors.forename: Zhengding
authors.initials: Z
authors.lastname: Su
authors.forename: Andrew
authors.initials: A
authors.lastname: Ward
authors.forename: Xiaowu Shirley
authors.initials: XS
authors.lastname: Tang