title: Anti-Trypanosoma cruzi and cytotoxic activities of Eugenia uniflora L.
abstract: Chagas disease is caused by Trypanosoma cruzi, being considered a public health problem. An alternative to combat this pathogen is the use of natural products isolated from fruits such as Eugenia uniflora, a plant used by traditional communities as food and medicine due to its antimicrobial and biological activities. Ethanolic extract from E. uniflora was used to evaluate in vitro anti-epimastigote and cytotoxic activity. This is the first record of anti-Trypanosoma activity of E. uniflora, demonstrating that a concentration presenting 50% of activity (EC(50)) was 62.76 μg/mL. Minimum inhibitory concentration (MIC) was ≤ 1024 μg/mL. Our results indicate that E. uniflora could be a source of plant-derived natural products with anti-epimastigote activity with low toxicity.
authors.affiliation: Laboratório de Microbiologia e Biologia Molecular, Universidade Regional do Cariri, Crato, CE, Brazil.
authors.forename: Karla K A
authors.initials: KK
authors.lastname: Santos
authors.forename: Edinardo F F
authors.initials: EF
authors.lastname: Matias
authors.forename: Saulo R
authors.initials: SR
authors.lastname: Tintino
authors.forename: Celestina E S
authors.initials: CE
authors.lastname: Souza
authors.forename: Maria F B M
authors.initials: MF
authors.lastname: Braga
authors.forename: Gláucia M M
authors.initials: GM
authors.lastname: Guedes
authors.forename: Miriam
authors.initials: M
authors.lastname: Rolón
authors.forename: Celeste
authors.initials: C
authors.lastname: Vega
authors.forename: Antonieta Rojas
authors.initials: AR
authors.lastname: de Arias
authors.forename: José G M
authors.initials: JG
authors.lastname: Costa
authors.forename: Irwin R A
authors.initials: IR
authors.lastname: Menezes
authors.forename: Henrique D M
authors.initials: HD
authors.lastname: Coutinho
mesh_terms: D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003124:Colorimetry; D008264:Macrophages / Q000166:cytology / Q000187:drug effects*; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D027842:Syzygium / Q000737:chemistry*; D014349:Trypanosoma cruzi / Q000187:drug effects*
chemical_list: D010936:Plant Extracts