title: Bioavailability of different preparations of paracetamol.
abstract: 1 Plasma drug concentrations in eight volunteer subjects following oral administration of six preparations of paracetamol have been studied. 2 Significant interindividual differences in plasma paracetamol concentration were found within 1 h but there were no consistent differences between the different drug preparations. The results indicate that all the preparations have equivalent bioavailability. 3 In four subjects, tested with the same preparation on two occasions, the findings suggest that drug absorption may differ from one occasion to another.
authors.affiliation: Department of Pharmacology, St Thomas's Hospital Medical School, London.
authors.forename: A
authors.initials: A
authors.lastname: Richter
authors.forename: S E
authors.initials: SE
authors.lastname: Smith