title: Nine kindreds of familial sticky platelet syndrome phenotype.
abstract: BACKGROUND
  Sticky platelet syndrome (SPS) is most likely a hereditary thrombophilia characterized by platelet hyperaggregation after low concentrations of platelet inducers--adenosine diphosphate and/or epinephrine. We present 9 kindreds with SPS familial occurrence.
  
  
  METHODS
  Familial trait of SPS was looked up in the database of the National Center of Hemostasis and Thrombosis. Families with at least 3 SPS-positive members were studied, described, and presented.
  
  
  RESULTS
  In the group of 1093 symptomatic patients, SPS was confirmed in 240 cases. Familial occurrence with at least 3 SPS-positive relatives was found in 9 cases.
  
  
  CONCLUSIONS
  The exact pathogenesis of SPS is not sufficiently explained. Our findings seem to support the idea that SPS might have an autosomal dominant hereditary fashion.
authors.affiliation: Department of Hematology and Transfusiology, National Center of Hemostasis and Thrombosis, Jessenius Faculty of Medicine, Comenius University, Martin University Hospital, Martin, Slovakia. radka.simon@gmail.com
authors.forename: Radoslava
authors.initials: R
authors.lastname: Šimonová
authors.forename: Lenka
authors.initials: L
authors.lastname: Bartosová
authors.forename: Peter
authors.initials: P
authors.lastname: Chudy
authors.forename: Ján
authors.initials: J
authors.lastname: Stasko
authors.forename: Stanislava
authors.initials: S
authors.lastname: Rumanová
authors.forename: Juraj
authors.initials: J
authors.lastname: Sokol
authors.forename: Peter
authors.initials: P
authors.lastname: Kubisz
mesh_terms: D000293:Adolescent; D000328:Adult; D001791:Blood Platelet Disorders / Q000235:genetics*; D002675:Child, Preschool; D005192:Family Health; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D010641:Phenotype; D013577:Syndrome; D019851:Thrombophilia / Q000235:genetics*; D055815:Young Adult