title: Preparation, characterization, and evaluation of a heparin-benzalkonium chloride-graphite oxide/polymethylvinyl siloxane nanocomposite.
abstract: A heparin (Hep)-benzalkonium chloride (C12)-graphite oxide (GO)/polymethylvinyl siloxane (PMVS) nancomposite was prepared via melting intercalation at different temperatures. Scanning electron microscopy images showed the Hep-C12-GO was well dispersed into PMVS processed at 100°C. Mechanical properties measurement demonstrated that the addition of Hep-C12-GO maintained its strength. XRD data indicated that Hep-C12-GO lost its layer structure completely. FTIR results suggested that Hep-C12-GO interacted with PMVS strongly. Antibacterial activity of resulting nanocomposite was evaluated using zone of inhibition and bacteria adhesion methods. The results demonstrated that Hep-C12-GO/PMVS had a good capability against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. Antithrombogenic properties were assessed using platelet adhesion experiment and the results showed that Hep-C12-GO/PMVS was blood-compatible.
authors.affiliation: Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210046, China. zhouninglin@njnu.edu.cn
authors.forename: Ninglin
authors.initials: N
authors.lastname: Zhou
authors.forename: Dong
authors.initials: D
authors.lastname: Xu
authors.forename: Jun
authors.initials: J
authors.lastname: Zhang
authors.forename: Yinchen
authors.initials: Y
authors.lastname: Ma
authors.forename: Jiang
authors.initials: J
authors.lastname: Yuan
authors.forename: Jian
authors.initials: J
authors.lastname: Shen
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001424:Bacterial Infections / Q000517:prevention & control; D001548:Benzalkonium Compounds / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D020099:Coated Materials, Biocompatible / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D006108:Graphite / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D006493:Heparin / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D008422:Materials Testing; D053761:Nanocomposites / Q000737:chemistry*; D010087:Oxides / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D010973:Platelet Adhesiveness / Q000187:drug effects; D011145:Polyvinyls / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012833:Siloxanes / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D001548:Benzalkonium Compounds; D020099:Coated Materials, Biocompatible; D010087:Oxides; D011145:Polyvinyls; D012833:Siloxanes; C014766:polymethylvinylsiloxane; D006108:Graphite; D006493:Heparin