title: The comparison of the effects of hepatic regeneration after partial hepatectomy, silybum marinaum, propofol, N-acetylcysteine and vitamin E on liver.
abstract: OBJECTIVE
  We investigated the comparison of the effects of N-acetylcysteine, silybum marinaum, propofol, and vitamin E on liver hepatic regeneration after partial hepatectomy.
  
  
  METHODS
  Forty-eight rats were randomized into 6 different groups of the same age and weight. After partial hepatectomy, all animals were resuscitated with 5 ml of isotonic sodium chloride solution administered subcutaneously while group 1 (sham) did not receive any injection, group 2 (control) received serum physiologic intraperitoneally, group 3 received 25 mg /kg of propofol intraperitoneally, group 4 received 20 mg/kg of N-acetylcysteine intraperitoneally, group 5 received 400 mg/kg of vitamin E intraperitoneally, and group 6 received 10 mg/kg of silybum intraperitoneally. None of these groups were given antibitotics. On the third day, a half of the rats, and on the seventh day, the other half of rats were reoperated and sacrificed.
  
  
  RESULTS
  Blood samples were used for biochemical parameters (AST, ALT). Ki-67 proliferation index was used for histopathologic parameters. A statistically meaningful difference was detected in silybum, vitamin E, N-acetylcysteine, and propofol groups for AST, ALT levels when compared to control and sham groups (p<0.05). Ki-67 regeneration proliferation index of all groups, which were given agents on the third and seventh days were statistically higher than the control and sham groups (p<0.05). During the evaluation, AST, ALT, Ki-67, Ro (regeneration value) levels of silybum group displayed a statistically significant difference according to other groups (p<0.05).
  
  
  CONCLUSIONS
  Our experimental study indicates that hepatic regeneration after partial hepatectomy was meaningful and significant in groups with intraperitoneal administration of silybum marinaum,vitamin E, N-acetylcysteine and propofol. Hepatic regeneration rate was particularly higher in silybum group compared to other groups (Fig. 16, Ref. 26).
authors.affiliation: Department of General Surgery, KSU, Faculty of Medicine, Kahramanmaras, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Yormaz
authors.forename: E
authors.initials: E
authors.lastname: Bulbuloglu
authors.forename: E B
authors.initials: EB
authors.lastname: Kurutas
authors.forename: H
authors.initials: H
authors.lastname: Ciralik
authors.forename: M F
authors.initials: MF
authors.lastname: Yuzbasioglu
authors.forename: H
authors.initials: H
authors.lastname: Yildiz
authors.forename: I
authors.initials: I
authors.lastname: Coskuner
authors.forename: E
authors.initials: E
authors.lastname: Silay
authors.forename: B
authors.initials: B
authors.lastname: Kantarceken
authors.forename: M
authors.initials: M
authors.lastname: Goksu
authors.forename: N
authors.initials: N
authors.lastname: Senoglu
authors.forename: I T
authors.initials: IT
authors.lastname: Kale
mesh_terms: D000111:Acetylcysteine / Q000494:pharmacology*; D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000494:pharmacology*; D006498:Hepatectomy; D008099:Liver / Q000187:drug effects*; D008115:Liver Regeneration / Q000187:drug effects*; D008297:Male; D020944:Silybum marianum; D028321:Plant Preparations / Q000494:pharmacology*; D015742:Propofol / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014810:Vitamin E / Q000494:pharmacology*
chemical_list: D018686:Anesthetics, Intravenous; D000975:Antioxidants; D016166:Free Radical Scavengers; D028321:Plant Preparations; D014810:Vitamin E; D000111:Acetylcysteine; D015742:Propofol