title: Functionalized mesoporous silica materials for controlled drug delivery.
abstract: In the past decade, non-invasive and biocompatible mesoporous silica materials as efficient drug delivery systems have attracted special attention. Great progress in structure control and functionalization (magnetism and luminescence) design has been achieved for biotechnological and biomedical applications. This review highlights the most recent research progress on silica-based controlled drug delivery systems, including: (i) pure mesoporous silica sustained-release systems, (ii) magnetism and/or luminescence functionalized mesoporous silica systems which integrate targeting and tracking abilities of drug molecules, and (iii) stimuli-responsive controlled release systems which are able to respond to environmental changes, such as pH, redox potential, temperature, photoirradiation, and biomolecules. Although encouraging and potential developments have been achieved, design and mass production of novel multifunctional carriers, some practical biological application, such as biodistribution, the acute and chronic toxicities, long-term stability, circulation properties and targeting efficacy in vivo are still challenging.
authors.affiliation: State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, PR China.
authors.forename: Piaoping
authors.initials: P
authors.lastname: Yang
authors.forename: Shili
authors.initials: S
authors.lastname: Gai
authors.forename: Jun
authors.initials: J
authors.lastname: Lin
mesh_terms: D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D008081:Liposomes / Q000737:chemistry; D049408:Luminescent Agents / Q000737:chemistry; D008280:Magnetics; D053758:Nanoparticles / Q000737:chemistry; D009369:Neoplasms / Q000188:drug therapy; D004364:Pharmaceutical Preparations / Q000008:administration & dosage; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D004337:Drug Carriers; D008081:Liposomes; D049408:Luminescent Agents; D004364:Pharmaceutical Preparations; D012822:Silicon Dioxide