title: The expression of the phosphatase regenerating liver 3 gene is associated with outcome in patients with colorectal cancer.
abstract: OBJECTIVE
  The phosphatase of regenerating liver-3 (PRL-3) is over expressed in several human cancers and associated with tumor progression, invasion and metastasis. However, the correlation between PRL-3 expression and clinical outcome in colorectal cancer (CRC) has not been investigated. This study examined the relationship between the relative expression of the PRL-3 gene to the clinicopathological factors and outcomes in patients with CRC.
  
  
  METHODS
  Surgical specimens of cancer tissue and adjacent normal mucosa were obtained from 202 patients with untreated CRC. The relative expression level of PRL-3 mRNA in cancer and in the normal adjacent mucosa was measured using the quantitative real-time reverse-transcriptase PCR.
  
  
  RESULTS
  PRL-3 expression was higher in cancer tissue than in the adjacent normal mucosa. The tumor location and liver metastasis were found to be related to the PRL-3 expression level. The overall survival differed significantly between patients with high PRL-3 expression and those with low expression.
  
  
  CONCLUSIONS
  High expression of the PRL-3 gene might be a useful predictor of poor postoperative outcome in patients with CRC.
authors.affiliation: Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Kanagawa, Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tamagawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Oshima
authors.forename: Kazue
authors.initials: K
authors.lastname: Yoshihara
authors.forename: Takuo
authors.initials: T
authors.lastname: Watanabe
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Numata
authors.forename: Naoto
authors.initials: N
authors.lastname: Yamamoto
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Tuschida
authors.forename: Manabu
authors.initials: M
authors.lastname: Shiozawa
authors.forename: Soichiro
authors.initials: S
authors.lastname: Morinaga
authors.forename: Makoto
authors.initials: M
authors.lastname: Akaike
authors.forename: Munetaka
authors.initials: M
authors.lastname: Masuda
authors.forename: Toshio
authors.initials: T
authors.lastname: lmada
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis* / Q000235:genetics; D016009:Chi-Square Distribution; D015179:Colorectal Neoplasms / Q000201:enzymology* / Q000235:genetics / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000201:enzymology / Q000556:secondary; D008297:Male; D015999:Multivariate Analysis; D009363:Neoplasm Proteins / Q000032:analysis* / Q000235:genetics; D016016:Proportional Hazards Models; D017027:Protein Tyrosine Phosphatases / Q000032:analysis* / Q000235:genetics; D012333:RNA, Messenger / Q000032:analysis; D060888:Real-Time Polymerase Chain Reaction; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013997:Time Factors; D016896:Treatment Outcome; D015854:Up-Regulation
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D012333:RNA, Messenger; C484730:PTP4A3 protein, human; D017027:Protein Tyrosine Phosphatases