title: Association between the human immune response and body mass index.
abstract: The aim of this study was to determine the strength of the association between the human immune response and body mass index (BMI) and whether differences exist in the effects of obesity on selected immune parameters between men and women. Two hundred ninety participants were divided into groups according to sex and BMI. Parameters CD3, CD4, CD8, CD16+56, CD19, HLADR, CD11b, CD11c, and CD54 were quantified. Leukocyte and differential counts were performed. We observed elevation with regard to the normal weight group in the parameters of white blood cells, neutrophils, monocytes, CD3, CD4, CD19, and CD11b for the whole study group. A decrease was observed in the expression of CD16+56. The effect of BMI on the immune system was much more apparent in women. BMI was correlated with the majority of the measured parameters, reflecting a strong association between BMI and the human immune system.
authors.affiliation: Department of Immunology and Immunotoxicology, Faculty of Medicine, Slovak Medical University in Bratislava, Limbova 12, 833 03 Bratislava, Slovak Republic. silvia.ilavska@szu.sk
authors.forename: Silvia
authors.initials: S
authors.lastname: Ilavská
authors.forename: Mira
authors.initials: M
authors.lastname: Horváthová
authors.forename: Michaela
authors.initials: M
authors.lastname: Szabová
authors.forename: Tomáš
authors.initials: T
authors.lastname: Nemessányi
authors.forename: Eva
authors.initials: E
authors.lastname: Jahnová
authors.forename: Jana
authors.initials: J
authors.lastname: Tulinská
authors.forename: Aurélia
authors.initials: A
authors.lastname: Líšková
authors.forename: Ladislava
authors.initials: L
authors.lastname: Wsolová
authors.forename: Marta
authors.initials: M
authors.lastname: Staruchová
authors.forename: Katarína
authors.initials: K
authors.lastname: Volkovová
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000096:biosynthesis / Q000276:immunology*; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007107:Immune System / Q000276:immunology / Q000473:pathology* / Q000503:physiopathology; D007113:Immunity, Innate; D007958:Leukocyte Count; D007962:Leukocytes / Q000276:immunology / Q000473:pathology; D008297:Male; D009000:Monocytes / Q000276:immunology / Q000473:pathology; D009504:Neutrophils / Q000276:immunology / Q000473:pathology; D009765:Obesity / Q000276:immunology / Q000473:pathology* / Q000503:physiopathology; D012737:Sex Factors
chemical_list: D015703:Antigens, CD