title: Regulation of T-cell responses and disease by tec kinase Itk.
abstract: Itk is a member of the Tec family tyrosine kinases involved in T-cell receptor signaling. The authors review the background and most recent findings of the role of Itk T-cell activation and development of αβ T cells. They also discuss the role of Itk in development of nonconventional T cells, including CD8(+) innate memory phenotype T cells, different γδ T-cell populations, and invariant NKT cells. They close by reviewing the regulation of T helper differentiation and cytokine secretion, the immune response to infectious disease, and diseases such as allergic asthma and atopic dermatitis by Itk.
authors.affiliation: Department of Microbiology & Immunology, Cornell University, Ithaca, New York, USA. averyaugust@cornell.edu
authors.forename: Avery
authors.initials: A
authors.lastname: August
authors.forename: Melanie J
authors.initials: MJ
authors.lastname: Ragin
mesh_terms: D000818:Animals; D003141:Communicable Diseases / Q000276:immunology*; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D008213:Lymphocyte Activation; D051379:Mice; D018345:Mice, Knockout; D011505:Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism*; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000378:metabolism*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D016693:Receptors, Antigen, T-Cell, alpha-beta; D011505:Protein-Tyrosine Kinases; C080813:emt protein-tyrosine kinase