title: Thyroid malignancy among goitrous thyroid lesions: a review of hospital-based studies in Malaysia and Myanmar.
abstract: Endemic goitre is a major concern in many parts of the world, including Southeast Asia. Goitrous thyroid lesion is postulated as a precursor lesion to thyroid cancer (TC). This paper reviews the prevalence rates and characteristics of TC among cases of goitrous thyroid-swelling in different parts of Malaysia and Myanmar. Recorded data from hospital-based retrospective studies of thyroid cases, whose study periods ranged from three to 11 years, were analysed. These included research findings from the author's publications as well as other published review articles of retrospective analyses. The incidence of TC varies among gender, age, race/ethnicity and histological type. There appears to be a higher rate of occurrence among females aged 21-60 years. Papillary thyroid carcinoma is the more common histological type compared to follicular cancer. This review also presents a descriptive analysis and discussion on studies conducted in other countries. Further exploration is warranted in order to uncover the possible risk factors for the rising incidence of TC.
authors.affiliation: Universiti Kuala Lumpur, Royal College of Medicine Perak, Malaysia. ththan@rcmp.unikl.edu.my
authors.forename: T T
authors.initials: TT
authors.lastname: Htwe
mesh_terms: D000328:Adult; D017677:Age Distribution; D001707:Biopsy, Needle; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D003906:Developing Countries; D005260:Female; D006043:Goiter, Endemic / Q000453:epidemiology* / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D015994:Incidence; D008296:Malaysia / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D002052:Myanmar / Q000453:epidemiology; D011230:Precancerous Conditions / Q000453:epidemiology / Q000473:pathology*; D018570:Risk Assessment; D017678:Sex Distribution; D013964:Thyroid Neoplasms / Q000453:epidemiology* / Q000473:pathology*; D055815:Young Adult