title: Lymphoproliferative disorders associated with hypereosinophilia.
abstract: Hypereosinophilia, defined as peripheral blood eosinophil counts > 1,500/μL, may complicate the course of various lymphoproliferative disorders. Among these, Hodgkin lymphoma (HL) and certain peripheral T-cell lymphomas (PTCLs) derived from CD4 cells, including Sezary syndrome (SS), adult T-cell leukemia/lymphoma (ATLL), and angioimmunoblastic T-cell lymphoma (AITL), are most commonly associated with increased reactive eosinophilopoiesis. Rarely, marked hypereosinophilia (HE) may occur in the setting of acute B-cell lymphoblastic leukemia, with a substantial impact on disease course. The mechanisms leading to blood and tissue eosinophilia in the setting of lymphoproliferative disorders, as well as the clinical complications and prognostic implications of hypereosinophilia, are discussed in this review.
authors.affiliation: Department of Internal Medicine, Hôpital Erasme, Université Libre de Bruxelles, 808 Route de Lennik, B-1070 Brussels, Belgium. froufoss@ulb.ac.be
authors.forename: Florence
authors.initials: F
authors.lastname: Roufosse
authors.forename: Soizic
authors.initials: S
authors.lastname: Garaud
authors.forename: Laurence
authors.initials: L
authors.lastname: de Leval
mesh_terms: D000818:Animals; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000276:immunology* / Q000473:pathology; D019891:Leukopoiesis / Q000276:immunology; D008232:Lymphoproliferative Disorders / Q000276:immunology* / Q000473:pathology