title: Chronological change in pulmonary vascular response to hypoxia in hepatopulmonary syndrome.
abstract: Here we present a case of hepatopulmonary syndrome (HPS) where spontaneous resolution of severe hypoxaemia occurred with the development of pulmonary hypertension over several years after the initial diagnosis of HPS. The pulmonary vascular responses to hypoxia examined before and after the spontaneous resolution of HPS confirmed that the pathogenesis of HPS could be functional and reversible in nature. To the best of our knowledge, this is the first report demonstrating a remarkable change in the pulmonary vascular response to hypoxia before and after the spontaneous resolution of hypoxaemia in HPS.
authors.affiliation: First Department of Medicine, Hokkaido University School of Medicine, Sapporo, Japan. ytanino@fmu.ac.jp
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Tanino
authors.forename: Hironi
authors.initials: H
authors.lastname: Makita
authors.forename: Ichizo
authors.initials: I
authors.lastname: Tsujino
authors.forename: Hideki
authors.initials: H
authors.lastname: Shinano
authors.forename: Masaharu
authors.initials: M
authors.lastname: Nishimura
mesh_terms: D002940:Circadian Rhythm; D005500:Follow-Up Studies; D020065:Hepatopulmonary Syndrome / Q000150:complications / Q000503:physiopathology*; D006801:Humans; D000860:Hypoxia / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011652:Pulmonary Circulation / Q000502:physiology*; D014655:Vascular Resistance / Q000502:physiology*