title: Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice.
abstract: The National Institute on Aging Interventions Testing Program (ITP) was established to evaluate agents that are hypothesized to increase life span and/or health span in genetically heterogeneous mice. Each compound is tested in parallel at three test sites. It is the goal of the ITP to publish all results, negative or positive. We report here on the results of lifelong treatment of mice, beginning at 4 months of age, with each of five agents, that is, green tea extract (GTE), curcumin, oxaloacetic acid, medium-chain triglyceride oil, and resveratrol, on the life span of genetically heterogeneous mice. Each agent was administered beginning at 4 months of age. None of these five agents had a statistically significant effect on life span of male or female mice, by log-rank test, at the concentrations tested, although a secondary analysis suggested that GTE might diminish the risk of midlife deaths in females only.
authors.affiliation: Geriatric Research, Education and Clinical Center and Research Service, South Texas Veterans Health Care System, TX, USA. strong@uthscsa.edu
authors.forename: Randy
authors.initials: R
authors.lastname: Strong
authors.forename: Richard A
authors.initials: RA
authors.lastname: Miller
authors.forename: Clinton M
authors.initials: CM
authors.lastname: Astle
authors.forename: Joseph A
authors.initials: JA
authors.lastname: Baur
authors.forename: Rafael
authors.initials: R
authors.lastname: de Cabo
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Fernandez
authors.forename: Wen
authors.initials: W
authors.lastname: Guo
authors.forename: Martin
authors.initials: M
authors.lastname: Javors
authors.forename: James L
authors.initials: JL
authors.lastname: Kirkland
authors.forename: James F
authors.initials: JF
authors.lastname: Nelson
authors.forename: David A
authors.initials: DA
authors.lastname: Sinclair
authors.forename: Bruce
authors.initials: B
authors.lastname: Teter
authors.forename: David
authors.initials: D
authors.lastname: Williams
authors.forename: Nurulain
authors.initials: N
authors.lastname: Zaveri
authors.forename: Nancy L
authors.initials: NL
authors.lastname: Nadon
authors.forename: David E
authors.initials: DE
authors.lastname: Harrison
mesh_terms: D000367:Age Factors; D000375:Aging / Q000187:drug effects / Q000473:pathology / Q000502:physiology; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003474:Curcumin / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D005260:Female; D008136:Longevity / Q000187:drug effects* / Q000235:genetics; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D023421:Models, Animal; D009043:Motor Activity / Q000187:drug effects; D062907:Oxaloacetic Acid / Q000494:pharmacology*; D011247:Pregnancy; D000077185:Resveratrol; D012727:Sex Characteristics; D013267:Stilbenes / Q000494:pharmacology*; D013662:Tea; D014280:Triglycerides / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D013267:Stilbenes; D013662:Tea; D014280:Triglycerides; D062907:Oxaloacetic Acid; D003474:Curcumin; D000077185:Resveratrol