title: Impact of ingestion of rice bran and shitake mushroom extract on lymphocyte function and cytokine production in healthy rats.
abstract: This article provides a controlled evaluation of the ability of dietary supplementation with a commercially available rice bran extract modified with shitake mushroom extract (MGN-3) to support the immune function by assessing the ability of immunocytes to proliferate and produce cytokines in response to a mitogenic challenge. Twenty-four male Lewis rats were fed a control diet (Maypo sweetened oatmeal) or Maypo containing the recommended daily dose of MGN-3 for 2 weeks. This treatment modestly enhanced mitogen enhanced proliferation of splenocytes and interferon-gamma (IFN-g) production, and significantly increased proliferation of splenocytes to the superantigen toxic shock syndrome toxin-1 (TSST-1) as well as natural killer (NK) cell activity and production of interleukin-2 (IL-2) by stimulated lymphocytes. These data support the contention that ingestion of MGN-3 can support immune cell function. These data add to a growing body of data showing that ingestion of MGN-3 improves the ability of immune cells to proliferate the lyse tumor cells, suggesting that it may have utility as a dietary aid to support the immune system.
authors.affiliation: University of Colorado at Denver and Health Sciences Center, Department of Psychology, Denver, CO 80217-3364, USA.
authors.forename: Scott
authors.initials: S
authors.lastname: Giese
authors.forename: George Richard
authors.initials: GR
authors.lastname: Sabell
authors.forename: Mary
authors.initials: M
authors.lastname: Coussons-Read
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D018554:Avena; D001427:Bacterial Toxins / Q000276:immunology; D049109:Cell Proliferation / Q000187:drug effects; D016207:Cytokines / Q000096:biosynthesis*; D019587:Dietary Supplements; D004768:Enterotoxins / Q000276:immunology; D007371:Interferon-gamma / Q000096:biosynthesis; D007376:Interleukin-2 / Q000096:biosynthesis; D007694:Killer Cells, Natural / Q000187:drug effects; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D008934:Mitogens / Q000276:immunology; D012275:Oryza / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D011917:Rats, Inbred Lew; D012016:Reference Values; D012639:Seeds; D020942:Shiitake Mushrooms; D013154:Spleen / Q000166:cytology / Q000187:drug effects; D018089:Superantigens / Q000276:immunology; D014990:Xylans / Q000494:pharmacology*
chemical_list: D000276:Adjuvants, Immunologic; D001427:Bacterial Toxins; D016207:Cytokines; D004768:Enterotoxins; D007376:Interleukin-2; D008934:Mitogens; D010936:Plant Extracts; D018089:Superantigens; D014990:Xylans; C030107:enterotoxin F, Staphylococcal; C419427:polysaccharide MGN3; D007371:Interferon-gamma