title: Synthesis of a new family of acyclic nucleoside phosphonates, analogues of TPases transition states.
abstract: A 6-step procedure was developed for the synthesis of a new family of acyclic nucleoside phosphonates (ANPs), "PHEEPA" [(2-pyrimidinyl-2-(2-hydroxyethoxy)ethyl)phosphonic acids] in overall yields ranging from 4.5% to 32%. These compounds, which possess on one side a hydroxy function and on the other side a phosphonate group, can be considered either as potential antiviral agents or as transition state analogues of nucleoside phosphorylases such as thymidine phosphorylase.
authors.affiliation: AM2N, Institut Charles Gerhardt, UMR 5253, ENSCM, 8 rue de l'Ecole Normale, F-34296 Montpellier, France.
authors.forename: Bénédicte
authors.initials: B
authors.lastname: Dayde
authors.forename: Samira
authors.initials: S
authors.lastname: Benzaria
authors.forename: Claire
authors.initials: C
authors.lastname: Pierra
authors.forename: Gilles
authors.initials: G
authors.lastname: Gosselin
authors.forename: Dominique
authors.initials: D
authors.lastname: Surleraux
authors.forename: Jean-Noël
authors.initials: JN
authors.lastname: Volle
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Pirat
authors.forename: David
authors.initials: D
authors.lastname: Virieux
mesh_terms: D040761:Biomimetic Materials / Q000138:chemical synthesis* / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D009705:Nucleosides / Q000737:chemistry*; D063065:Organophosphonates / Q000138:chemical synthesis* / Q000737:chemistry*; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry*; D013939:Thymidine Phosphorylase / Q000737:chemistry*
chemical_list: D009705:Nucleosides; D063065:Organophosphonates; D011743:Pyrimidines; D013939:Thymidine Phosphorylase