title: Calcium signalling remodelling and disease.
abstract: A wide range of Ca2+ signalling systems deliver the spatial and temporal Ca2+ signals necessary to control the specific functions of different cell types. Release of Ca2+ by InsP3 (inositol 1,4,5-trisphosphate) plays a central role in many of these signalling systems. Ongoing transcriptional processes maintain the integrity and stability of these cell-specific signalling systems. However, these homoeostatic systems are highly plastic and can undergo a process of phenotypic remodelling, resulting in the Ca2+ signals being set either too high or too low. Such subtle dysregulation of Ca2+ signals have been linked to some of the major diseases in humans such as cardiac disease, schizophrenia, bipolar disorder and Alzheimer's disease.
authors.affiliation: Babraham Institute, Babraham, Cambridge CB22 3AT, U.K. michael.berridge@babraham.ac.uk
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Berridge
mesh_terms: D002021:Buffers; D015220:Calcium Channels / Q000378:metabolism; D020013:Calcium Signaling; D004194:Disease; D006801:Humans; D010641:Phenotype; D011956:Receptors, Cell Surface / Q000378:metabolism
chemical_list: D002021:Buffers; D015220:Calcium Channels; D011956:Receptors, Cell Surface