title: Foveal avascular zone and its relationship to foveal pit shape.
abstract: OBJECTIVE
  To investigate the retinal microvasculature at the fovea and peripheral retina in humans using an adaptive optics scanning laser ophthalmoscope (AOSLO) and to examine the association of foveal avascular zone (FAZ) and foveal pit morphology.
  
  
  METHODS
  Retinal imaging of the foveal capillary network was performed on 11 subjects (15 eyes; age range 20 to 54 years) with an AOSLO. Standard deviation maps of the AOSLO images were generated from ∼10 to 30 frames, producing high-resolution maps delineating the complete capillary distribution of the retina. Foveal pit morphology was investigated in the same subjects by using a spectral domain optical coherence tomography. In an additional subject, only a relatively large retinal vasculature map was obtained using AOSLO.
  
  
  RESULTS
  A well-demarcated FAZ was seen in 11 subjects tested with foveal capillary imaging. There was considerable individual variation in the size and shape of the FAZ. The mean FAZ area and mean FAZ effective diameter were 0.33 mm(2) and 622 μm, respectively. Foveal thickness was found to be negatively correlated with the FAZ effective diameter.
  
  
  CONCLUSIONS
  The structure of the capillary network could be evaluated in the fovea and parafovea using our approach. We find that a smaller FAZ is associated with a narrower foveal pit opening and a thicker fovea.
authors.affiliation: School of Optometry, Indiana University, Bloomington, Indiana 47405, USA.
authors.forename: Toco Y P
authors.initials: TY
authors.lastname: Chui
authors.forename: Zhangyi
authors.initials: Z
authors.lastname: Zhong
authors.forename: Hongxin
authors.initials: H
authors.lastname: Song
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Burns
mesh_terms: D000328:Adult; D002196:Capillaries / Q000166:cytology; D005260:Female; D005584:Fovea Centralis / Q000098:blood supply*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012171:Retinal Vessels / Q000033:anatomy & histology*; D041623:Tomography, Optical Coherence / Q000379:methods*; D055815:Young Adult