title: Detecting molecular selection on single amino acid replacements.
abstract: Amino acid property methods have repeatedly proven more sensitive than nucleotide-based methods, especially to the subtle influences of selection on Single Nucleotide Polymorphisms (SNPs). The purpose of this study is to evaluate the effects of population sampling and sliding window size on the sensitivity of one amino acid based method by assessing drug resistant SNPs from the HIV-1 gag-pol gene. The analysis of most of the SNPs produced positive results. There was not a trend in terms of properties affected most often, but sliding window size affected results more than population sampling.
authors.affiliation: Bigelow Laboratory for Ocean Sciences, West Boothbay Harbor, ME 04575 - 0475, USA. dmcclellan@bigelow.org
authors.forename: David A
authors.initials: DA
authors.lastname: McClellan
mesh_terms: D000596:Amino Acids / Q000235:genetics*; D024882:Drug Resistance, Viral / Q000235:genetics; D015685:Fusion Proteins, gag-pol / Q000235:genetics*; D015497:HIV-1 / Q000235:genetics / Q000378:metabolism; D020641:Polymorphism, Single Nucleotide
chemical_list: D000596:Amino Acids; D015685:Fusion Proteins, gag-pol