title: Evaluation of the anti-resorptive ability of an experimental acetazolamide paste for the treatment of late replanted teeth: a study in rats.
abstract: When late replantation is performed, the root surface and root canal should be treated. Notwithstanding failures still occur, because of the high rates of root resorption, evidencing the need to search for substances that may inhibit root resorption. The acetazolamide is a known anti-resorptive agent, and its use as root canal dressing may increase the success rates in the treatment of root resorption. Therefore, this study evaluated the effect of an acetazolamide paste used as root canal dressing in late replanted teeth. The study was conducted on 24 maxillary right incisors of rats, which were avulsed and divided in two groups. In group I, the teeth were kept dry for 30 min, had their root surfaces rubbed with a blade, and were treated with 2% sodium fluoride at pH 5.5 for 20 min; the root canals were instrumented and filled with acetazolamide paste; and then the teeth were replanted. In group II, the treatment was similar to group I, except for the root canal dressing, with utilization of calcium hydroxide in group II. At 15 and 60 days after replantation, the animals were killed and the specimens were processed in a histotechnical laboratory for microscopic and morphometric analysis. The results demonstrated the ability of both intracanal substances to limit root resorption, yet they were unable to completely inhibit the root resorption. Replacement resorption lacunae were present in greater proportion in group II, at 60 days. It was concluded that the acetazolamide paste was effective to limit the root resorption, being more effective in limiting the replacement resorption compared with calcium hydroxide.
authors.affiliation: Integrated Clinic at Araçatuba Dental School, Unesp, Brazil. grazielagm@hotmail.com
authors.forename: Graziela Garrido
authors.initials: GG
authors.lastname: Mori
authors.forename: Wilson Roberto
authors.initials: WR
authors.lastname: Poi
authors.forename: Lithiene Ribeiro
authors.initials: LR
authors.lastname: Castilho
mesh_terms: D000086:Acetazolamide / Q000627:therapeutic use*; D000818:Animals; D050071:Bone Density Conservation Agents / Q000627:therapeutic use*; D002126:Calcium Hydroxide / Q000627:therapeutic use; D003094:Collagen; D003238:Connective Tissue / Q000473:pathology; D003739:Dental Cementum / Q000473:pathology; D003890:Desiccation; D006863:Hydrogen-Ion Concentration; D007180:Incisor / Q000187:drug effects / Q000293:injuries; D008297:Male; D010513:Periodontal Ligament / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D012387:Root Canal Filling Materials / Q000627:therapeutic use*; D012388:Root Canal Irrigants / Q000627:therapeutic use; D018915:Root Canal Preparation / Q000379:methods; D012391:Root Resorption / Q000473:pathology / Q000517:prevention & control*; D012973:Sodium Hypochlorite / Q000627:therapeutic use; D013997:Time Factors; D020254:Tooth Ankylosis / Q000209:etiology / Q000473:pathology; D014084:Tooth Avulsion / Q000628:therapy; D014090:Tooth Replantation / Q000379:methods*; D014092:Tooth Root / Q000473:pathology
chemical_list: D050071:Bone Density Conservation Agents; D012387:Root Canal Filling Materials; D012388:Root Canal Irrigants; D003094:Collagen; D012973:Sodium Hypochlorite; D000086:Acetazolamide; D002126:Calcium Hydroxide