title: Concomitant chemoradiotherapy as a standard treatment for squamous cell carcinoma of the temporal bone.
abstract: We sought to characterize the effectiveness of concomitant chemoradiotherapy (CCRT) for patients with squamous cell carcinoma of the temporal bone. We performed a retrospective chart review of 14 patients with cancer of the temporal bone who were provided initial treatment in our hospital from December 2001 to November 2008. Four patients with stage I tumors were treated by radiation therapy alone or with oral administration of S1. One patient with a stage II tumor was treated by radiation therapy concomitant with low dose docetaxel. Nine patients with stage IV tumors were treated by CCRT using the TPF regimen (docetaxel, cisplatin, and 5-fluorouracil). As an initial treatment, all patients but one were treated by radiation therapy with or without chemotherapy. Grade 4 adverse events of patients who received CCRT using the TPF regimen involved the leukopenia in one patient and the neutropenia in two patients. Local recurrences were observed in three patients including two patients with T4 tumors. Five-year disease-specific survival rates for all patients and for patients with T4 tumors were 78% and 67%, respectively. CCRT using the TPF regimen is safe and effective as the first treatment for patients with cancer of the temporal bone.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, Tohoku University Hospital, Sendai, Japan.
authors.forename: Kiyoto
authors.initials: K
authors.lastname: Shiga
authors.forename: Takenori
authors.initials: T
authors.lastname: Ogawa
authors.forename: Atsuko
authors.initials: A
authors.lastname: Maki
authors.forename: Masanori
authors.initials: M
authors.lastname: Amano
authors.forename: Toshimitsu
authors.initials: T
authors.lastname: Kobayashi