title: Vancomycin levels are frequently subtherapeutic during continuous venovenous hemodialysis (CVVHD).
abstract: Continuous renal replacement therapy (CRRT) is frequently used in the intensive care setting for the treatment of acute kidney injury. Dosing guidelines for many commonly used antibiotics were established during intermittent dialysis or in studies examining CRRT at lower blood and dialysis flow rates than are used in common practice. Herein we present data demonstrating frequent subtherapeutic levels of vancomycin in a population of patients on CRRT. Nephrology trainees should be educated as to the risks of under-dosing antibiotics in this population.
authors.affiliation: University of Pennsylvania Health System, Department of Medicine, Philadelphia, PA, USA. francis.wilson@uphs.upenn.edu
authors.forename: F Perry
authors.initials: FP
authors.lastname: Wilson
authors.forename: Jeffrey S
authors.initials: JS
authors.lastname: Berns
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000097:blood*; D003422:Critical Care; D016903:Drug Monitoring; D006801:Humans; D007362:Intensive Care Units; D007676:Kidney Failure, Chronic / Q000401:mortality / Q000628:therapy*; D007902:Length of Stay; D008875:Middle Aged; D006435:Renal Dialysis / Q000379:methods / Q000401:mortality; D012189:Retrospective Studies; D013203:Staphylococcal Infections / Q000517:prevention & control; D016019:Survival Analysis; D016896:Treatment Outcome; D014640:Vancomycin / Q000008:administration & dosage* / Q000097:blood*
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin