title: A rare case of Trichosporon brain abscess, successfully treated with surgical excision and antifungal agents.
abstract: Trichosporonosis is an acute, sometimes fatal infection with the potential capability of disseminating to multiple deep organs. More than 100 cases of trichosporonosis have been described, particularly in patients with neutropenia or haematological malignancies. In 1970, Watson et al. described the first case of brain trichosporonosis; the patient died 4 weeks after admission. Herein, we describe a 34-year-old man with a history of autoimmune hepatitis, hypothyroidism, and alopecia totalis, treated with corticosteroids, who was admitted with left lower limb weakness. Brain MRI revealed a diffuse brain lesion in the right frontoparietal area mimicking a brain abscess. After resection of the lesion, Trichosporon asahii was isolated from the abscess. Further treatment with antifungal agents resulted in improvement in clinical status. To the best of our knowledge, this is the second case of Trichosporon brain abscess since the first description in 1970 and the first case of successful treatment of Trichosporon brain abscess.
authors.affiliation: Neurology Department, Isfahan University of Medical Sciences, Iran.
authors.forename: Keivan
authors.initials: K
authors.lastname: Basiri
authors.forename: Mohsen
authors.initials: M
authors.lastname: Meidani
authors.forename: Farshid
authors.initials: F
authors.lastname: Rezaie
authors.forename: Shabnam
authors.initials: S
authors.lastname: Soheilnader
authors.forename: Farzad
authors.initials: F
authors.lastname: Fatehi
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D001922:Brain Abscess / Q000175:diagnosis* / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D008297:Male; D016896:Treatment Outcome; D014250:Trichosporon / Q000302:isolation & purification*; D060586:Trichosporonosis / Q000175:diagnosis* / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000935:Antifungal Agents