title: Mesenchymal stem cells restore orientation and exploratory behavior of rats after brain injury.
abstract: We studied the effects of intravenous and intracerebral transplantation of MSC on restoration of orientation and exploratory behavior of Wistar-Kyoto rats after removal of the left motor cortex. Removal of the motor cortex led to a significant reduction of the number of behavioral acts in the open field test. Two weeks after removal of the motor cortex and intravenous transplantation, the animals were as inhibited as the controls, but during the next 10 weeks, the behavioral status of these rats remained unchanged, while controls exhibited further behavioral degradation. After injection of MSC into the brain, the behavior of rats with trauma did not change in comparison with intact rats over 10 weeks.
authors.affiliation: Trans-Technologies, St. Petersburg, Russia.
authors.forename: I B
authors.initials: IB
authors.lastname: Sokolova
authors.forename: O R
authors.initials: OR
authors.lastname: Fedotova
authors.forename: S G
authors.initials: SG
authors.lastname: Tsikunov
authors.forename: D G
authors.initials: DG
authors.lastname: Polyntsev
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D001930:Brain Injuries / Q000473:pathology / Q000628:therapy*; D002540:Cerebral Cortex / Q000293:injuries* / Q000473:pathology; D005106:Exploratory Behavior / Q000502:physiology*; D007275:Injections, Intravenous; D007276:Injections, Intraventricular; D008297:Male; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology / Q000502:physiology; D009043:Motor Activity / Q000502:physiology; D009949:Orientation / Q000502:physiology; D051381:Rats; D011921:Rats, Inbred WKY; D020127:Recovery of Function / Q000502:physiology*