title: Chemiluminescent identification and quantification of artemisinin and relevant sesquiterpene lactone derivatives.
abstract: A simple, sensitive, and rapid chemiluminescence method was developed for the detection and quantification of selected derivatives of artemisinin. It was found that the chemiluminescence (CL) signal resulting from the alkaline luminol reaction of the artemisinin derivatives in the presence of hematin was linear over a wide concentration range. We report results that suggest that a visual test or a test involving digital image capture may be used in addition to a field-ready instrumental approach to combat drug counterfeiting of malarial therapies.
authors.affiliation: Department of Chemistry, 501 East Saint Joseph Street, South Dakota School of Mines and Technology, Rapid City, South Dakota 57701, USA.
authors.forename: David J
authors.initials: DJ
authors.lastname: Bowles
authors.forename: Andrew S
authors.initials: AS
authors.lastname: Olson
authors.forename: Neal H
authors.initials: NH
authors.lastname: Hodges
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Heglund
authors.forename: Roberto L
authors.initials: RL
authors.lastname: Vargas
authors.forename: Scott A
authors.initials: SA
authors.lastname: Williams
mesh_terms: D037621:Artemisinins / Q000032:analysis* / Q000737:chemistry; D002138:Calibration; D058110:Counterfeit Drugs / Q000032:analysis / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D007783:Lactones / Q000032:analysis / Q000737:chemistry; D057230:Limit of Detection; D049408:Luminescent Agents / Q000737:chemistry; D008163:Luminescent Measurements / Q000379:methods; D008165:Luminol / Q000737:chemistry; D012717:Sesquiterpenes / Q000032:analysis* / Q000737:chemistry; D013050:Spectrometry, Fluorescence / Q000379:methods*
chemical_list: D037621:Artemisinins; D058110:Counterfeit Drugs; D007783:Lactones; D049408:Luminescent Agents; D012717:Sesquiterpenes; D008165:Luminol