title: Synthesis and evaluation of anticancer natural product analogues based on angelmarin: targeting the tolerance towards nutrient deprivation.
abstract: Inspired by nature: Angelmarin is an anticancer natural product with potent antiausterity activity, that is, selective cytotoxicity towards nutrient-deprived, resistant cancer cells. Through structure-activity relationship studies, three analogues were identified as lead compounds for the develpoment of molecular probes for the investigation of the mode of action and biological targets of the antiausterity compounds.
authors.affiliation: Eskitis Institute for Cell and Molecular Therapies (N75), Griffith University, Nathan, QLD, Australia.
authors.forename: Jakob
authors.initials: J
authors.lastname: Magolan
authors.forename: Nathan B P
authors.initials: NB
authors.lastname: Adams
authors.forename: Hiroko
authors.initials: H
authors.lastname: Onozuka
authors.forename: Natasha L
authors.initials: NL
authors.lastname: Hungerford
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Esumi
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Coster
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D001688:Biological Products / Q000737:chemistry; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D003374:Coumarins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005502:Food; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D010190:Pancreatic Neoplasms / Q000188:drug therapy; D010936:Plant Extracts / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013237:Stereoisomerism; D013312:Stress, Physiological / Q000502:physiology; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D001688:Biological Products; D003374:Coumarins; D010936:Plant Extracts; C508941:angelmarin