title: Targeted entry of enveloped viruses: measles and herpes simplex virus I.
abstract: We compare the receptor-based mechanisms that a small RNA virus and a larger DNA virus have evolved to drive the fusion of viral and cellular membranes. Both systems rely on tight control over triggering the concerted refolding of a trimeric fusion protein. While measles virus entry depends on a receptor-binding protein and a fusion protein only, the herpes simplex virus (HSV) is more complex and requires four viral proteins. Nevertheless, in both viruses a receptor-binding protein is required for triggering the membrane fusion process. Moreover, specificity domains can be appended to these receptor-binding proteins to target virus entry to cells expressing a designated receptor. We discuss how principles established with measles and HSV can be applied to targeting other enveloped viruses, and alternatively how retargeted envelopes can be fitted on foreign capsids.
authors.affiliation: Department of Molecular Medicine, Virology and Gene Therapy Track, Mayo Graduate School, Rochester, MN 55905, USA.
authors.forename: Chanakha K
authors.initials: CK
authors.lastname: Navaratnarajah
authors.forename: Tanner S
authors.initials: TS
authors.lastname: Miest
authors.forename: Andrea
authors.initials: A
authors.lastname: Carfi
authors.forename: Roberto
authors.initials: R
authors.lastname: Cattaneo
mesh_terms: D000818:Animals; D006561:Herpes Simplex / Q000378:metabolism / Q000821:virology*; D018259:Herpesvirus 1, Human / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008457:Measles / Q000378:metabolism / Q000821:virology*; D008459:Measles virus / Q000235:genetics / Q000502:physiology*; D011991:Receptors, Virus / Q000378:metabolism; D014759:Viral Envelope Proteins / Q000235:genetics / Q000378:metabolism; D053586:Virus Internalization
chemical_list: D011991:Receptors, Virus; D014759:Viral Envelope Proteins