title: Ischemic neuroprotection by TRPV1 receptor-induced hypothermia.
abstract: Although treatment of stroke patients with mild hypothermia is a promising therapeutic approach, chemicals inducing prompt and safe reduction of body temperature are an unmet need. We measured the effects of the transient receptor potential vanilloid-1 (TRPV1) agonist rinvanil on thermoregulation and ischemic brain injury in mice. Intraperitoneal or intracerebroventricular injection of rinvanil induces mild hypothermia that is prevented by the receptor antagonist capsazepine. Both intraischemic and postischemic treatments provide permanent neuroprotection in animals subjected to transient middle cerebral artery occlusion (MCAo), an effect lost in mice artificially kept normothermic. Data indicate that TRPV1 receptor agonists are promising candidates for hypothermic treatment of stroke.
authors.affiliation: Department of Pharmacology, University of Florence, Viale Pieraccini 6, Florence, Italy. mirko.muzzi@unifi.it
authors.forename: Mirko
authors.initials: M
authors.lastname: Muzzi
authors.forename: Roberta
authors.initials: R
authors.lastname: Felici
authors.forename: Leonardo
authors.initials: L
authors.lastname: Cavone
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Gerace
authors.forename: Alberto
authors.initials: A
authors.lastname: Minassi
authors.forename: Giovanni
authors.initials: G
authors.lastname: Appendino
authors.forename: Flavio
authors.initials: F
authors.lastname: Moroni
authors.forename: Alberto
authors.initials: A
authors.lastname: Chiarugi
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000628:therapy; D007036:Hypothermia, Induced / Q000379:methods*; D008297:Male; D051379:Mice; D018696:Neuroprotective Agents / Q000494:pharmacology*; D020521:Stroke / Q000628:therapy*; D050916:TRPV Cation Channels / Q000819:agonists*
chemical_list: D018696:Neuroprotective Agents; D050916:TRPV Cation Channels; C493921:TRPV1 protein, mouse