title: Preparation, characterization, and cellular associations of silicon logic-embedded vectors.
abstract: Logic-embedded vectors (LEVs) have been introduced as a means to overcome sequential, biological barriers that prevent particle-based drug delivery systems from reaching their targets. In this chapter, we address the challenge of fabricating and optimizing LEVs to reach non-endosomal targets. We describe the general preparation, characterization, and cellular association of porous silicon-based LEVs. A specific example of LEV fabrication from start to finish, along with optimization and troubleshooting information, is presented to serve as a template for future designs.
authors.affiliation: Department of Nanomedicine, The Methodist Hospital Research Institute, Houston, Texas, USA.
authors.forename: Anne L
authors.initials: AL
authors.lastname: van de Ven
authors.forename: Aaron
authors.initials: A
authors.lastname: Mack
authors.forename: Kenneth
authors.initials: K
authors.lastname: Dunner
authors.forename: Mauro
authors.initials: M
authors.lastname: Ferrari
authors.forename: Rita E
authors.initials: RE
authors.lastname: Serda
mesh_terms: D048271:Chitosan / Q000737:chemistry; D004337:Drug Carriers; D016503:Drug Delivery Systems; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D012825:Silicon / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties
chemical_list: D004337:Drug Carriers; D048271:Chitosan; D012825:Silicon