title: Type I interferons: diversity of sources, production pathways and effects on immune responses.
abstract: Type I interferons (IFN-I) were first described over 50 years ago as factors produced by cells that interfere with virus replication and promote an antiviral state. Innate and adaptive immune responses to viruses are also greatly influenced by IFN-I. In this article we discuss the diversity of cellular sources of IFN-I and the pathways leading to IFN-I production during viral infections. Finally, we discuss the effects of IFN-I on cells of the immune system with emphasis on dendritic cells.
authors.affiliation: Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, United States.
authors.forename: Melissa
authors.initials: M
authors.lastname: Swiecki
authors.forename: Marco
authors.initials: M
authors.lastname: Colonna
mesh_terms: D000818:Animals; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D007370:Interferon Type I / Q000276:immunology*; D051192:Receptors, Pattern Recognition / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology / Q000821:virology; D014779:Virus Replication / Q000276:immunology; D014780:Viruses / Q000276:immunology*
chemical_list: D007370:Interferon Type I; D051192:Receptors, Pattern Recognition