title: Genetic and molecular basis of nonhost disease resistance: complex, yes; silver bullet, no.
abstract: Nonhost resistance (NHR), in which a successful pathogen on some plants fails to overcome host barriers on others, has attracted much attention owing to its potential for robust crop improvement. Recent advances reveal that a multitude of underlying mechanisms contribute to NHR, ranging from components shared with recognition-based defenses up to recessive susceptibility factors involved in plant primary metabolism. Most NHR appears multi-factorial and quantitative. This implies that there is no single, 'silver bullet' NHR mechanism that can be used to broadly restrict pathogens in many or all crops.
authors.affiliation: Department of Plant Pathology, China Agricultural University, Beijing 100193, China. jfan@cau.edu.cn
authors.forename: Jun
authors.initials: J
authors.lastname: Fan
authors.forename: Peter
authors.initials: P
authors.lastname: Doerner
mesh_terms: D018556:Crops, Agricultural / Q000235:genetics*; D060467:Disease Resistance / Q000235:genetics*; D054884:Host-Pathogen Interactions / Q000235:genetics* / Q000276:immunology*; D057865:Plant Immunity / Q000235:genetics*; D010944:Plants / Q000382:microbiology* / Q000821:virology*