title: Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population.
abstract: Rheumatoid arthritis is a common autoimmune disease characterized by chronic inflammation. We report a meta-analysis of genome-wide association studies (GWAS) in a Japanese population including 4,074 individuals with rheumatoid arthritis (cases) and 16,891 controls, followed by a replication in 5,277 rheumatoid arthritis cases and 21,684 controls. Our study identified nine loci newly associated with rheumatoid arthritis at a threshold of P < 5.0 × 10(-8), including B3GNT2, ANXA3, CSF2, CD83, NFKBIE, ARID5B, PDE2A-ARAP1, PLD4 and PTPN2. ANXA3 was also associated with susceptibility to systemic lupus erythematosus (P = 0.0040), and B3GNT2 and ARID5B were associated with Graves' disease (P = 3.5 × 10(-4) and 2.9 × 10(-4), respectively). We conducted a multi-ancestry comparative analysis with a previous meta-analysis in individuals of European descent (5,539 rheumatoid arthritis cases and 20,169 controls). This provided evidence of shared genetic risks of rheumatoid arthritis between the populations.
authors.affiliation: Laboratory for Autoimmune Diseases, Center for Genomic Medicine, RIKEN, Yokohama, Japan.
authors.forename: Yukinori
authors.initials: Y
authors.lastname: Okada
authors.forename: Chikashi
authors.initials: C
authors.lastname: Terao
authors.forename: Katsunori
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authors.lastname: Ikari
authors.forename: Yuta
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authors.lastname: Kochi
authors.forename: Koichiro
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authors.lastname: Ohmura
authors.forename: Akari
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authors.lastname: Suzuki
authors.forename: Takahisa
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authors.lastname: Kawaguchi
authors.forename: Eli A
authors.initials: EA
authors.lastname: Stahl
authors.forename: Fina A S
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authors.lastname: Kurreeman
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authors.forename: Hiroko
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authors.lastname: Ohmiya
authors.forename: Keiko
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authors.lastname: Myouzen
authors.forename: Meiko
authors.initials: M
authors.lastname: Takahashi
authors.forename: Tetsuji
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authors.lastname: Sawada
authors.forename: Yuichi
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authors.lastname: Nishioka
authors.forename: Masao
authors.initials: M
authors.lastname: Yukioka
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Matsubara
authors.forename: Shigeyuki
authors.initials: S
authors.lastname: Wakitani
authors.forename: Ryota
authors.initials: R
authors.lastname: Teshima
authors.forename: Shigeto
authors.initials: S
authors.lastname: Tohma
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Takasugi
authors.forename: Kota
authors.initials: K
authors.lastname: Shimada
authors.forename: Akira
authors.initials: A
authors.lastname: Murasawa
authors.forename: Shigeru
authors.initials: S
authors.lastname: Honjo
authors.forename: Keitaro
authors.initials: K
authors.lastname: Matsuo
authors.forename: Hideo
authors.initials: H
authors.lastname: Tanaka
authors.forename: Kazuo
authors.initials: K
authors.lastname: Tajima
authors.forename: Taku
authors.initials: T
authors.lastname: Suzuki
authors.forename: Takuji
authors.initials: T
authors.lastname: Iwamoto
authors.forename: Yoshiya
authors.initials: Y
authors.lastname: Kawamura
authors.forename: Hisashi
authors.initials: H
authors.lastname: Tanii
authors.forename: Yuji
authors.initials: Y
authors.lastname: Okazaki
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Sasaki
authors.forename: Peter K
authors.initials: PK
authors.lastname: Gregersen
authors.forename: Leonid
authors.initials: L
authors.lastname: Padyukov
authors.forename: Jane
authors.initials: J
authors.lastname: Worthington
authors.forename: Katherine A
authors.initials: KA
authors.lastname: Siminovitch
authors.forename: Mark
authors.initials: M
authors.lastname: Lathrop
authors.forename: Atsuo
authors.initials: A
authors.lastname: Taniguchi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takahashi
authors.forename: Katsushi
authors.initials: K
authors.lastname: Tokunaga
authors.forename: Michiaki
authors.initials: M
authors.lastname: Kubo
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Kamatani
authors.forename: Tsuneyo
authors.initials: T
authors.lastname: Mimori
authors.forename: Robert M
authors.initials: RM
authors.lastname: Plenge
authors.forename: Hisashi
authors.initials: H
authors.lastname: Yamanaka
authors.forename: Shigeki
authors.initials: S
authors.lastname: Momohara
authors.forename: Ryo
authors.initials: R
authors.lastname: Yamada
authors.forename: Fumihiko
authors.initials: F
authors.lastname: Matsuda
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Yamamoto
mesh_terms: D001172:Arthritis, Rheumatoid / Q000453:epidemiology* / Q000235:genetics*; D016022:Case-Control Studies; D056426:Genetic Loci; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D007564:Japan / Q000453:epidemiology; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D005819:Genetic Markers