title: Abdominal aortic calcification in young adult survivors of childhood acute lymphoblastic leukemia: results from the St. Jude Lifetime Cohort study.
abstract: Abdominal aortic calcification (AAC), metabolic syndrome, and low bone mineral density (BMD) are risk factors for atherosclerotic disease and cardiovascular morbidity. We evaluated AAC in 662 adult survivors of childhood ALL (median age 31 years). AAC was present in 10% of subjects, metabolic syndrome in 36%, and low BMD in 29%. The adjusted odds ratio (OR) for AAC among women with metabolic syndrome was 2.3 (95% CL = 1.0, 4.3). The adjusted OR for AAC in men with low BMD was 3.1 (95% CL = 1.3, 7.3). A substantial proportion of adult survivors of childhood ALL have AAC and/or metabolic syndrome, suggestive of early atherosclerotic disease.
authors.affiliation: Department of Epidemiology and Cancer Control, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA. james.gurney@stjude.org
authors.forename: James G
authors.initials: JG
authors.lastname: Gurney
authors.forename: Rohit P
authors.initials: RP
authors.lastname: Ojha
authors.forename: Kirsten K
authors.initials: KK
authors.lastname: Ness
authors.forename: Sujuan
authors.initials: S
authors.lastname: Huang
authors.forename: Shelly
authors.initials: S
authors.lastname: Sharma
authors.forename: Leslie L
authors.initials: LL
authors.lastname: Robison
authors.forename: Melissa M
authors.initials: MM
authors.lastname: Hudson
authors.forename: Sue C
authors.initials: SC
authors.lastname: Kaste
mesh_terms: D000328:Adult; D001012:Aorta, Abdominal; D001018:Aortic Diseases / Q000209:etiology*; D050197:Atherosclerosis / Q000209:etiology; D015519:Bone Density; D002114:Calcinosis / Q000209:etiology*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000209:etiology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000628:therapy; D012307:Risk Factors; D017741:Survivors