title: Merging organocatalysis with transition metal catalysis: highly stereoselective α-alkylation of aldehydes.
abstract: The unprecedented cooperative systems involving a diarylprolinol silyl ether with various Lewis acids have been found to effect the highly enantioselective intermolecular α-alkylation of aldehydes. A wide variety of aldehydes and alcohols can be transformed into the desired highly functionalized aldehydes in high yields, excellent enantioselectivities, and good diastereoselectivities at room temperature under mild conditions.
authors.affiliation: Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, P. R. China. xiaojian@dicp.ac.cn
authors.forename: Jian
authors.initials: J
authors.lastname: Xiao
mesh_terms: D000438:Alcohols / Q000737:chemistry*; D000447:Aldehydes / Q000138:chemical synthesis* / Q000737:chemistry; D000478:Alkylation; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D058116:Lewis Acids / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000438:Alcohols; D000447:Aldehydes; D058116:Lewis Acids