title: Role of dendritic cells in the formation of subpopulation of cytotoxic T-lymphocytes in the thymus during its aging.
abstract: The counts of dendritic cells and cytotoxic T-lymphocytes in the thymus decrease during its aging. The counts of dendritic cells decrease in senile age, while low counts of cytotoxic T-cells are observed only in long-living individuals. Presumably, reduction of the counts of thymic dendritic cells causes disorders in the differentiation of T-cells, particularly of cytotoxic ones, which can represent a mechanism of thymus involution during its aging.
authors.affiliation: St. Petersburg Institute of Bioregulation and Gerontology, North Western Division of Russian Academy of Medical Sciences, Russia. miayy@yandex.ru
authors.forename: N S
authors.initials: NS
authors.lastname: Linkova
authors.forename: V O
authors.initials: VO
authors.lastname: Polyakova
authors.forename: I M
authors.initials: IM
authors.lastname: Kvetnoy
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D015415:Biomarkers / Q000032:analysis; D016827:CD8 Antigens / Q000032:analysis; D002454:Cell Differentiation; D003713:Dendritic Cells / Q000166:cytology* / Q000276:immunology; D006801:Humans; D008875:Middle Aged; D017463:Receptors, Complement 3b / Q000032:analysis; D013602:T-Lymphocytes, Cytotoxic / Q000166:cytology* / Q000276:immunology; D013950:Thymus Gland / Q000166:cytology*
chemical_list: D015415:Biomarkers; D016827:CD8 Antigens; D017463:Receptors, Complement 3b