title: Effect of Boswellia serrata on antioxidant status in an experimental model of colitis rats induced by acetic acid.
abstract: OBJECTIVE
  To evaluate the antioxidant effect of an extract of the plant Boswellia serrata in an experimental model of acute ulcerative colitis induced by administration of acetic acid (AA) in rats.
  
  
  METHODS
  The extract of B. serrata (34.2 mg/kg/day) was administered orally by gavage for 2 days before and after induction of colitis with AA diluted to 4 % and in a volume of 4 ml.
  
  
  RESULTS
  The anal sphincter pressure in the groups treated with B. serrata showed a significant increase compared to the colitis group (P < 0.001). Histological analysis of treated animals showed less edema with preservation of mucosal crypts. Lipid peroxidation showed a significant decrease in the treated groups compared to the colitis group (P < 0.001). The superoxide dismutase (SOD) enzyme activity showed a significant reduction in the treated groups compared to the colitis group (P < 0.001), the glutathione peroxidase (GPx) significantly increased in the treated groups compared to colitis group (P < 0.05), and the same was the result for enzyme activity glutathione (GSH; P < 0.05).
  
  
  CONCLUSIONS
  The extract of B. serrata has active antioxidant substances that exert protective effects in acute experimental colitis.
authors.affiliation: Programa de Pós-Graduação em Medicina: Ciências Médicas, Universidade Federal do Rio Grande do Sul, Rua José Kanan Aranha no 102, Porto Alegre, Rio Grande do Sul, CEP.: 91760-470, Brazil.
authors.forename: Renata Minuzzo
authors.initials: RM
authors.lastname: Hartmann
authors.forename: Maria Isabel
authors.initials: MI
authors.lastname: Morgan Martins
authors.forename: Juliana
authors.initials: J
authors.lastname: Tieppo
authors.forename: Henrique Sarubbi
authors.initials: HS
authors.lastname: Fillmann
authors.forename: Norma Possa
authors.initials: NP
authors.lastname: Marroni
mesh_terms: D019342:Acetic Acid; D001003:Anal Canal / Q000187:drug effects; D000818:Animals; D029743:Boswellia; D003092:Colitis / Q000188:drug therapy* / Q000473:pathology; D003106:Colon / Q000473:pathology; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D010936:Plant Extracts; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione; D019342:Acetic Acid