title: An exploratory epidemiological study of Langerhans cell histiocytosis.
abstract: We explored potential risk factors associated with Langerhans cell histiocytosis (LCH) in a predominantly Hispanic population in Los Angeles. Sixty children with LCH (cases) and, 150 randomly selected patients (controls) were interviewed. There was no statistically significant difference between cases and controls in the following: Family history of thyroid disease, smokers in the family, maternal problems during pregnancy, and pesticide exposure. Cases were more likely to report a family history of cancer (OR 2.5), infection during infancy (OR 2.76), and parental occupational exposure to metal, granites, or wood dust (OR 2.48).
authors.affiliation: Division of Hematology/Oncology, Children's Hospital Los Angeles, Los Angeles, CA 90027, USA.
authors.forename: Rajkumar
authors.initials: R
authors.lastname: Venkatramani
authors.forename: Shira
authors.initials: S
authors.lastname: Rosenberg
authors.forename: Gitanjali
authors.initials: G
authors.lastname: Indramohan
authors.forename: Michael
authors.initials: M
authors.lastname: Jeng
authors.forename: Rima
authors.initials: R
authors.lastname: Jubran
mesh_terms: D000293:Adolescent; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006630:Hispanic or Latino; D006646:Histiocytosis, Langerhans-Cell / Q000453:epidemiology* / Q000208:ethnology / Q000235:genetics; D006801:Humans; D007223:Infant; D015141:Los Angeles / Q000453:epidemiology; D008297:Male; D012307:Risk Factors