title: Association of colorectal adenoma with components of metabolic syndrome.
abstract: OBJECTIVE
  Recently, some studies have shown that diabetes mellitus and metabolic syndrome increase the risk of colorectal neoplasms. Although the mechanism is not known, those have been proposed to contribute to this phenomenon, including insulin resistance, oxidative stress, and adipokine production. The objective of this study was to assess the association between metabolic risk factors and colorectal neoplasm.
  
  
  METHODS
  Study participants visited the National Cancer Center, Korea, for screening (2007-2009). A total of 1,771 diagnosed adenoma patients and 4,667 polyp-free controls were included. The association between risk factors and colorectal neoplasm was evaluated using logistic regression models.
  
  
  RESULTS
  High waist circumference, blood pressure, and serum triglyceride levels were associated with an increased risk of colorectal adenoma. Metabolic syndrome (MS) was associated with an increased risk of adenoma (OR = 1.44, 95 % CI = 1.23-1.70). The association between MS and colorectal adenoma was observed regardless of advanced/low-risk adenoma, and multiplicity. MS affected right colon adenomas (OR = 1.50, 95 % CI = 1.22-1.85), left colon adenomas (OR = 1.36, 95 % CI = 1.05-1.76), and adenomas in multiple anatomical locations (OR = 1.59, 95 % CI = 1.19-2.12), but was not associated with rectum.
  
  
  CONCLUSIONS
  Central obesity, triglyceride level, and MS are risk factors for colorectal adenoma including advanced adenoma and multiplicity.
authors.affiliation: Center for Colorectal Cancer, Research Institute and Hospital of National Cancer Center, Goyang-si, Korea.
authors.forename: Byung Chang
authors.initials: BC
authors.lastname: Kim
authors.forename: Aesun
authors.initials: A
authors.lastname: Shin
authors.forename: Chang Won
authors.initials: CW
authors.lastname: Hong
authors.forename: Dae Kyung
authors.initials: DK
authors.lastname: Sohn
authors.forename: Kyung Su
authors.initials: KS
authors.lastname: Han
authors.forename: Kum Hei
authors.initials: KH
authors.lastname: Ryu
authors.forename: Bum Joon
authors.initials: BJ
authors.lastname: Park
authors.forename: Ji Hyung
authors.initials: JH
authors.lastname: Nam
authors.forename: Ji Won
authors.initials: JW
authors.lastname: Park
authors.forename: Hee Jin
authors.initials: HJ
authors.lastname: Chang
authors.forename: Hyo Seong
authors.initials: HS
authors.lastname: Choi
authors.forename: Jeongseon
authors.initials: J
authors.lastname: Kim
authors.forename: Jae Hwan
authors.initials: JH
authors.lastname: Oh
mesh_terms: D000236:Adenoma / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D000328:Adult; D000368:Aged; D015992:Body Mass Index; D003113:Colonoscopy / Q000379:methods; D015179:Colorectal Neoplasms / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D024821:Metabolic Syndrome / Q000150:complications / Q000453:epidemiology*; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000453:epidemiology; D056128:Obesity, Abdominal / Q000150:complications / Q000453:epidemiology; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors; D014280:Triglycerides; D055105:Waist Circumference
chemical_list: D014280:Triglycerides