title: Ageing in Werner syndrome.
abstract: Oxidative stress markers including pentosidine and homocysteine were examined comparing them with inflammation markers including highly sensitive C-reactive protein (hsCRP) and matrix metalloproteinase-9 (MMP-9) in serum from patients with Werner syndrome (WS) and healthy individuals. Elevation of serum pentosidine correlated significantly with normal aging in healthy individuals (p < 0.0004). Serum pentosidine in WS increased significantly compared with age-matched healthy individuals (p < 0.05). Serum homocysteine levels increased insignificantly with normal aging in healthy individuals and in WS compared with age-matched healthy individuals. As both pentosidine and homocysteine levels did not correlate with hsCRP or MMP-9, both oxidative stress markers may be differentially regulated by inflammation.
authors.affiliation: Division of Anti-ageing and Longevity Sciences, Department of Medical Technology, Toin University of Yokohama, Yokohama, Kanagawa, Japan. goto@cc.toin.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Goto
authors.forename: S
authors.initials: S
authors.lastname: Iwaki-Egawa
authors.forename: Y
authors.initials: Y
authors.lastname: Watanabe
mesh_terms: D000328:Adult; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood / Q000473:pathology*; D001120:Arginine / Q000031:analogs & derivatives / Q000097:blood; D005260:Female; D006262:Health; D006710:Homocysteine / Q000097:blood; D006801:Humans; D008239:Lysine / Q000031:analogs & derivatives / Q000097:blood; D008297:Male; D008875:Middle Aged; D014898:Werner Syndrome / Q000097:blood / Q000473:pathology*
chemical_list: D006710:Homocysteine; D001120:Arginine; C062187:pentosidine; D008239:Lysine