title: Immunomodulatory efficiency of poly(2-oxazolines).
abstract: Poly(2-oxazolines) represent promising polymer materials for biomedical applications. The activation of mouse lymphoid macrophage line P388.D1 (clone 3124) by two selected representatives of poly(2-oxazolines), namely poly(2-ethyl-2-oxazoline) (PETOX100) and poly[2-(4-aminophenyl)-2-oxazoline-co-2-ethyl-2-oxazoline] (AEOX10), was assessed in vitro. The immunomodulatory efficacy of both polymers was evaluated via the induced release of pro-inflammatory cytokines (TNF-α, IL-1α and IL-6) and the acceleration of reactive free radicals. The present study revealed effective structure-immunomodulating associations of AEOX10 and PETOX100, which are desirable in biomedical and pharmaceutical applications of aliphatic and aromatic poly (2-oxazolines) in vivo.
authors.affiliation: Polymer Institute, Slovak Academy of Sciences, Centre of Excellence GLYCOMED, Bratislava, Slovakia. upolkron@savba.sk
authors.forename: Juraj
authors.initials: J
authors.lastname: Kronek
authors.forename: Ema
authors.initials: E
authors.lastname: Paulovičová
authors.forename: Lucia
authors.initials: L
authors.lastname: Paulovičová
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Kroneková
authors.forename: Jozef
authors.initials: J
authors.lastname: Lustoň
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D007155:Immunologic Factors / Q000737:chemistry / Q000494:pharmacology*; D053582:Interleukin-1alpha / Q000096:biosynthesis; D015850:Interleukin-6 / Q000096:biosynthesis; D008262:Macrophage Activation / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008422:Materials Testing; D051379:Mice; D010080:Oxazoles / Q000737:chemistry / Q000494:pharmacology; D011073:Polyamines / Q000737:chemistry / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D017550:Spectroscopy, Fourier Transform Infrared; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
chemical_list: C552863:2-(4-aminophenyl)-2-oxazoline; D001672:Biocompatible Materials; D007155:Immunologic Factors; D053582:Interleukin-1alpha; D015850:Interleukin-6; D010080:Oxazoles; D011073:Polyamines; D017382:Reactive Oxygen Species; D014409:Tumor Necrosis Factor-alpha; C511916:poly(2-ethyl-2-oxazoline); C552862:2-ethyl-2-oxazoline