title: Association of type 2 diabetes mellitus with coronary atherosclerotic plaque burden and morphology measured by multidetector computed tomography coronary angiography.
abstract: OBJECTIVE
  Diabetes mellitus (DM) is strongly associated with increased risk of coronary artery disease (CAD). The aim of this study was to determine differences in presence, extent and morphology of coronary atherosclerotic plaques (CAP) detected by multidetector computed tomography (MDCT) between symptomatic patients with and without diabetes.
  
  
  METHODS
  The CAPs (calcified, non-calcified, mixed) were compared between patients with/without diabetes (104/257 DM; mean age 58.6 +/- 11 y; 46.3% male) who underwent dual-source 64-slice MDCT for evaluation of CAD. Severity, extent and morphology of CAPs were determined per each segment.
  
  
  RESULTS
  Critical coronary stenosis was higher in patients with diabetes (33.7% vs. 19.6%) after adjustment for all risk factors (P = 0.022). Patients with DM had a higher prevalence and extent of CAP compared to non-diabetic subjects (87.5% vs. 43.8%, 4.8 +/- 3.5 vs. 1.9 +/- 2.7, respectively; P < 0.001). Noncalcified and mixed CAP were more prevalent in patients with diabetes as compared to those without diabetes (2.61 +/- 2.63 vs. 0.86 +/- 1.69, 0.81 +/- 1.6 vs. 0.35 +/- 0.96, respectively, P < 0.001). Patients with DM tended to have higher prevalence of significant 1-, 2- and 3-vessel disease (P = 0.006).
  
  
  CONCLUSIONS
  Among individuals referred for the evaluation of CAD, those with DM had a higher risk of coronary stenosis and overall increased CAP burden independent from other cardiovascular risk factors shown by MDCT. Further studies are needed to evaluate the prognostic value of different plaque compositions observed in patients with diabetes.
authors.affiliation: Department of Cardiology, Hacettepe University Faculty of Medicine, Ankara, Turkey. dru_canpolat@yahoo.com
authors.forename: Uğur
authors.initials: U
authors.lastname: Canpolat
authors.forename: Kudret
authors.initials: K
authors.lastname: Aytemir
authors.forename: Hikmet
authors.initials: H
authors.lastname: Yorgun
authors.forename: Tuncay
authors.initials: T
authors.lastname: Hazirolan
authors.forename: Ergün Bariş
authors.initials: EB
authors.lastname: Kaya
authors.forename: Ahmet Hakan
authors.initials: AH
authors.lastname: Ateş
authors.forename: Hamza
authors.initials: H
authors.lastname: Sunman
authors.forename: Muhammet
authors.initials: M
authors.lastname: Dural
authors.forename: Muhammed Ulvi
authors.initials: MU
authors.lastname: Yalçin
authors.forename: Lale
authors.initials: L
authors.lastname: Tokgözoğlu
authors.forename: Giray
authors.initials: G
authors.lastname: Kabakçi
authors.forename: Ali
authors.initials: A
authors.lastname: Oto
mesh_terms: D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000150:complications* / Q000000981:diagnostic imaging* / Q000473:pathology; D048909:Diabetes Complications / Q000000981:diagnostic imaging* / Q000473:pathology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D061330:Multidetector Computed Tomography