title: Ten paths to the discovery of antivirally active nucleoside and nucleotide analogues.
abstract: Nucleoside and nucleotide analogues have proven to be an effective approach toward the development of antiviral compounds. This approach has so far yielded a number of clinically useful antiviral drugs, such as BVDU (brivudin), (val)aciclovir, cidofovir, adefovir dipivoxil, and tenofovir disoproxil fumarate, and current perspectives justify the further development of other nucleoside analogues, such as FV-100, and that of the DAPy-based nucleotide analogues, the 5-aza analogue of cidofovir, and prodrug derivatives thereof.
authors.affiliation: Rega Institute for Medical Research, Katholieke Universiteit Leuven, Leuven, Belgium. erik.declercq@rega.kuleuven.be
authors.forename: Erik
authors.initials: E
authors.lastname: De Clercq
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000266:history*; D055808:Drug Discovery / Q000266:history* / Q000639:trends; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D009705:Nucleosides / Q000737:chemistry / Q000266:history*; D009711:Nucleotides / Q000737:chemistry / Q000266:history*
chemical_list: D000998:Antiviral Agents; D009705:Nucleosides; D009711:Nucleotides