title: Protein S-nitrosylation and cancer.
abstract: Protein S-nitrosylation is a covalent post-translational modification through coupling of a nitric oxide (NO) moiety with the reactive thiol group of a protein cysteine residue to form an S-nitrosothiol (SNO). S-nitrosylation is a key mechanism in the transmission of NO-based cellular signals in the vital cellular processes, including transcription regulation, DNA repair, and apoptosis. Contemporary research has implicated dysregulation of S-nitrosylation in severe pathological events, including cancer onset, progression, and treatment resistance. The S-nitrosylation status may be directly linked to many cancer therapy outcomes as well as therapeutic-resistance, emphasizing the need to develop S-nitrosylation-related anti-cancer therapeutics. The role of S-nitrosylated proteins in the development and progression of cancer are varied, generating a critical need for a thorough review of the current dynamic research in this area.
authors.affiliation: Beijing Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, PR China. clairezqwang@hotmail.com
authors.forename: Zhaoqing
authors.initials: Z
authors.lastname: Wang
mesh_terms: D018450:Disease Progression; D054638:Dual Specificity Phosphatase 1 / Q000737:chemistry; D006801:Humans; D009369:Neoplasms / Q000235:genetics* / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism*; D011499:Protein Processing, Post-Translational; D026403:S-Nitrosothiols / Q000378:metabolism
chemical_list: D026403:S-Nitrosothiols; D009569:Nitric Oxide; C517019:DUSP1 protein, human; D054638:Dual Specificity Phosphatase 1