title: Effect of Quercetin in the 1-Methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-Induced Mouse Model of Parkinson's Disease.
abstract: In this paper, the protective effect of the bioflavonoid quercetin on behaviors, antioxidases, and neurotransmitters in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine-(MPTP-) induced Parkinson's disease (PD) was investigated. Quercetin treatment (50 mg/kg, 100 mg/kg and 200 mg/kg body weight) was orally administered for 14 consecutive days. The results show that quercetin treatment markedly improves the motor balance and coordination of MPTP-treated mice. Significant increases were observed in the activities of glutathione peroxidase (GPx), superoxide dismutase (SOD), and Na(+), K(+)-ATPase, AchE, the content of dopamine (DA) in the quercetin plus MPTP groups compared to those in the MPTP group. Significant reduction the 4-hydroxy-2-nonenal (4-HNE) immunoreactivity in striatum of brains was observed in the quercetin plus MPTP groups in comparison to the MPTP group. Taken together, we propose that quercetin has shown antiparkinsonian properties in our studies. More work is needed to explore detailed mechanisms of action.
authors.affiliation: Department of Pharmacology, School of Pharmacy, Jilin University, Changchun 130021, China.
authors.forename: Chuanfeng
authors.initials: C
authors.lastname: Lv
authors.forename: Tie
authors.initials: T
authors.lastname: Hong
authors.forename: Zhen
authors.initials: Z
authors.lastname: Yang
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Lu
authors.initials: L
authors.lastname: Wang
authors.forename: Man
authors.initials: M
authors.lastname: Dong
authors.forename: Jing
authors.initials: J
authors.lastname: Zhao
authors.forename: Jiaye
authors.initials: J
authors.lastname: Mu
authors.forename: Yixiao
authors.initials: Y
authors.lastname: Meng