title: Regioselective Cu(I)-catalyzed tandem A3-coupling/decarboxylative coupling to 3-amino-1,4-enynes.
abstract: An efficient and novel copper-mediated protocol for the synthesis of 3-amino-1,4-enynes from glyoxylic acid, an amine, and an alkyne was developed. This new reaction involving two sequential C-C bond formations is air and moisture tolerant and proceeds via a tandem A(3)-coupling and a selective decarboxylative coupling.
authors.affiliation: Laboratory for Organic & Microwave-Assisted Chemistry, Department of Chemstry, Katholieke Universiteit Leuven, Celestijnenlaan 200F, B-3001 Leuven, Belgium.
authors.forename: Huangdi
authors.initials: H
authors.lastname: Feng
authors.forename: Denis S
authors.initials: DS
authors.lastname: Ermolat'ev
authors.forename: Gonghua
authors.initials: G
authors.lastname: Song
authors.forename: Erik V
authors.initials: EV
authors.lastname: Van der Eycken
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis* / Q000737:chemistry; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D006038:Glyoxylates / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D000588:Amines; D006038:Glyoxylates; D003300:Copper; C031150:glyoxylic acid