title: Potent and selective butyrylcholinesterase inhibitors from Ficus foveolata.
abstract: Four stilbenes (1-4), one inseparable mixture of two alkyl diferulates (5a, 5b), one alkyl ferulate (6) and four flavonoids (7-10) were isolated from Ficus foveolata Wall. Except for quercetin (10), the other ten constituents were isolated from F. foveolata for the first time. In addition, one of the two components in mixture 5 is a new compound identified as (1E,22E)-1,22-docosanediol diferulate (5a). All nine isolated compounds, plus the mixture of 5a and 5b known as 5, exhibited a low or no activity against acetylcholinesterase. However, and interestingly, the stilbenes 1-4 showed a high inhibition towards butyrylcholinesterase. Gnetol (4) had the lowest IC(50) value of 1.3μM towards butyrylcholinesterase and showed a reversible and competitive inhibition in the kinetic study.
authors.affiliation: Natural Products Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, 254 Phayathai Road, Bangkok 10330, Thailand.
authors.forename: Thiendanai
authors.initials: T
authors.lastname: Sermboonpaisarn
authors.forename: Pattara
authors.initials: P
authors.lastname: Sawasdee
mesh_terms: D000818:Animals; D002091:Butyrylcholinesterase / Q000378:metabolism*; D002800:Cholinesterase Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D030681:Ficus / Q000737:chemistry*; D006736:Horses; D020128:Inhibitory Concentration 50; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D013267:Stilbenes / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: C575171:(1E,22E)-1,22-docosanediol diferulate; C476734:2,3',5',6-tetrahydroxy-trans-stilbene; D002800:Cholinesterase Inhibitors; D010936:Plant Extracts; D013267:Stilbenes; D002091:Butyrylcholinesterase