title: Allurin, an amphibian sperm chemoattractant having implications for mammalian sperm physiology.
abstract: Eggs of many species are surrounded by extracellular coats that emit ligands to which conspecific sperm respond by undergoing chemotaxis and changes in metabolism, motility, and acrosomal status in preparation for fertilization. Here we review methods used to measure sperm chemotaxis and focus on recent studies of allurin, a 21-kDa protein belonging to the Cysteine-RIch Secretory Protein (CRISP) family that has chemoattraction activity for both amphibian and mammalian sperm. Allurin is unique in being the first extensively characterized Crisp protein found in the female reproductive tract and is the product of a newly discovered amphibian gene within a gene cluster that has been largely conserved in mammals. Study of its expression, function, and tertiary structure could lead to new insights in the role of Crisp proteins in sperm physiology.
authors.affiliation: Department of Animal Science, University of Illinois, Urbana-Champaign, Urbana, Illinois, USA.
authors.forename: Lindsey A
authors.initials: LA
authors.lastname: Burnett
authors.forename: Catherine A
authors.initials: CA
authors.lastname: Washburn
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Sugiyama
authors.forename: Xueyu
authors.initials: X
authors.lastname: Xiang
authors.forename: John H
authors.initials: JH
authors.lastname: Olson
authors.forename: Bader
authors.initials: B
authors.lastname: Al-Anzi
authors.forename: Allan L
authors.initials: AL
authors.lastname: Bieber
authors.forename: Douglas E
authors.initials: DE
authors.lastname: Chandler
mesh_terms: D000595:Amino Acid Sequence; D000663:Amphibians / Q000378:metabolism*; D000818:Animals; D002352:Carrier Proteins / Q000737:chemistry / Q000494:pharmacology*; D002630:Chemotactic Factors / Q000737:chemistry / Q000494:pharmacology*; D002633:Chemotaxis / Q000187:drug effects; D004527:Egg Proteins / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008322:Mammals / Q000502:physiology*; D008969:Molecular Sequence Data; D013094:Spermatozoa / Q000187:drug effects* / Q000502:physiology*
chemical_list: D002352:Carrier Proteins; D002630:Chemotactic Factors; D004527:Egg Proteins; C438377:allurin