title: A novel bioactive vitroceramic presents similar biological responses as autogenous bone grafts.
abstract: Bioactive glasses represent an interesting class of bone substitute's biomaterials. The present study investigated the repair of bone defects filled with a novel bioactive vitroceramic (Biosilicate(®)), alone or in association with particulate autogenous bone grafts in calvaria defects of rabbits. After 7, 14, and 30 days the specimens were retrieved for histological, histomorphometric and immunohistochemistry analysis. Satisfactory bone formation was observed in all groups, and direct bone-biomaterial surface was noted. Histomorphometric assessment did not show statistically significant differences in bone formation among the groups and periods, except for BG group at day 14. Immunoexpression of Runx-2 was similar among the groups containing the graft and the biomaterial, being more intense than in control group. Similar result was observed for VEGF expression, especially in the last experimental period. These results revealed that Biosilicate(®) presented a favorable behavior, comparable to autogenous bone graft.
authors.affiliation: Department of Health Sciences, Universidade Sagrado Coração-USC, Chácara das Flores, Bauru, SP, Brazil. vicmak.blv@terra.com.br
authors.forename: Mariza Akemi
authors.initials: MA
authors.lastname: Matsumoto
authors.forename: Gustavo
authors.initials: G
authors.lastname: Caviquioli
authors.forename: Claudia Cristina
authors.initials: CC
authors.lastname: Biguetti
authors.forename: Leandro de Andrade
authors.initials: Lde A
authors.lastname: Holgado
authors.forename: Patrícia Pinto
authors.initials: PP
authors.lastname: Saraiva
authors.forename: Ana Claudia Muniz
authors.initials: AC
authors.lastname: Rennó
authors.forename: Roberto Yoshio
authors.initials: RY
authors.lastname: Kawakami
mesh_terms: D000818:Animals; D001861:Bone Regeneration / Q000502:physiology; D018786:Bone Substitutes / Q000737:chemistry*; D016025:Bone Transplantation; D002516:Ceramics; D050659:Core Binding Factor Alpha 1 Subunit / Q000378:metabolism; D005898:Glass; D007150:Immunohistochemistry; D008297:Male; D008422:Materials Testing; D011817:Rabbits; D012887:Skull Fractures / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D013997:Time Factors; D014182:Transplantation, Autologous; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism
chemical_list: D018786:Bone Substitutes; D050659:Core Binding Factor Alpha 1 Subunit; D042461:Vascular Endothelial Growth Factor A; C120461:sodium oxide-calcium oxide-silicon dioxide-diphosphorus pentoxide