title: [Relationship of c-kit and platelet-derived growth factor receptor alpha gene mutation features with prognosis of patients with gastrointestinal stromal tumor].
abstract: OBJECTIVE
  To explore the relationship between c-kit and platelet-derived growth factor receptor alpha(PDGFRA) gene mutation features and the prognosis of gastrointestinal stromal tumor(GIST).
  
  
  METHODS
  Clinicopathological, genetic testing and follow-up informations of patients admitted to the Shanxi Tumor Hospital from June 2000 to January 2009 were collected. The survival was calculated and univariate analysis was conducted using the Kaplan-Meier method. Multivariate analysis was conducted by the Cox regression method.
  
  
  RESULTS
  The 5-year disease-free survival rate was 61.5% and the 5-year overall survival rate was 67.4%.  The 5-year disease-free survival rates of patients without disease among those with c-kit exon 11 mutation (n=77), c-kit exon 9 mutation(n=4), and PDGFRA exon 18 mutation (n=2) were 63.4%, 14.3% and 100%, and the 5-year overall survival rates were 70.8%, 50.0% and 100%, respectively. In the patients with c-kit exon 11 mutation, the 5-year disease-free survival rates among those with point mutations(n=26), deletion mutations(n=44), and duplication mutations(n=7) were 87.1%, 44.9% and 80.0%, and the 5-year overall survival rates were 88.1%, 57.0% and 100%, respectively. There were significant differences in overall survival among different factors. Multivariate analysis showed that gene mutation was not the independent factor of prognosis(P=0.492).
  
  
  CONCLUSIONS
  In GIST patients undergoing surgery without imatinib treatment, mutated genotype is better than wild type in terms of prognosis. Gene mutation is not the independent factor of prognosis in GIST patients.
authors.affiliation: Department of Anus and Intestine Surgery, Shanxi Tumor Hospital, Taiyuan 030013, China.
authors.forename: Chao-yi
authors.initials: CY
authors.lastname: Li
authors.forename: Xiao-bo
authors.initials: XB
authors.lastname: Liang
authors.forename: Jun-jie
authors.initials: JJ
authors.lastname: Ma
authors.forename: Hui-yuan
authors.initials: HY
authors.lastname: Jiang
authors.forename: Xue-zhong
authors.initials: XZ
authors.lastname: Hu
authors.forename: Dong
authors.initials: D
authors.lastname: Yan
authors.forename: Sheng-huai
authors.initials: SH
authors.lastname: Hou
authors.forename: Li-ping
authors.initials: LP
authors.lastname: Wang
mesh_terms: D004252:DNA Mutational Analysis; D005260:Female; D005500:Follow-Up Studies; D046152:Gastrointestinal Stromal Tumors / Q000235:genetics / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011379:Prognosis; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics*; D020796:Receptor, Platelet-Derived Growth Factor alpha / Q000235:genetics*
chemical_list: D019009:Proto-Oncogene Proteins c-kit; D020796:Receptor, Platelet-Derived Growth Factor alpha