title: Verticillosides A-M: Polyoxygenated pregnane glycosides from Asclepias verticillata L.
abstract: As part of our ongoing effort to explore the chemical diversity of plants of the United States Midwest region, the isolation and identification of 13 pregnane glycosides named verticillosides A-M from Asclepias verticillata L. are reported. The structures of these compounds were elucidated by various spectroscopic techniques, including 1D and 2D NMR, IR, UV, and HRMS. The cytotoxicity of the isolates was evaluated against paired breast cell lines Hs578T (cancer) and Hs578Bst (normal), however, no significant growth inhibition was observed.
authors.affiliation: Department of Medicinal Chemistry, University of Kansas, Lawrence, KS 66045, USA.
authors.forename: Juan J
authors.initials: JJ
authors.lastname: Araya
authors.forename: Franklin
authors.initials: F
authors.lastname: Binns
authors.forename: Kelly
authors.initials: K
authors.lastname: Kindscher
authors.forename: Barbara N
authors.initials: BN
authors.lastname: Timmermann
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D031108:Asclepias / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D011278:Pregnanes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014481:United States
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D006027:Glycosides; D011278:Pregnanes