title: Theoretical aspects of immunity.
abstract: The immune system recognizes a myriad of invading pathogens and their toxic products. It does so with a finite repertoire of antibodies and T cell receptors. We here describe theories that quantify the dynamics of the immune system. We describe how the immune system recognizes antigens by searching the large space of receptor molecules. We consider in some detail the theories that quantify the immune response to influenza and dengue fever. We review theoretical descriptions of the complementary evolution of pathogens that occurs in response to immune system pressure. Methods including bioinformatics, molecular simulation, random energy models, and quantum field theory contribute to a theoretical understanding of aspects of immunity.
authors.affiliation: Department of Bioengineering and Physics, Rice University, Houston, TX 77005, USA. mwdeem@rice.edu
authors.forename: Michael W
authors.initials: MW
authors.lastname: Deem
authors.forename: Pooya
authors.initials: P
authors.lastname: Hejazi
mesh_terms: D000818:Animals; D005075:Biological Evolution; D019295:Computational Biology / Q000379:methods; D003715:Dengue / Q000276:immunology; D003716:Dengue Virus / Q000276:immunology; D006801:Humans; D007107:Immune System / Q000276:immunology*; D007109:Immunity; D009980:Influenza A virus / Q000276:immunology; D007251:Influenza, Human / Q000276:immunology; D008954:Models, Biological; D008958:Models, Molecular