title: Dose-responses from multi-model inference for the non-cancer disease mortality of atomic bomb survivors.
abstract: The non-cancer mortality data for cerebrovascular disease (CVD) and cardiovascular diseases from Report 13 on the atomic bomb survivors published by the Radiation Effects Research Foundation were analysed to investigate the dose-response for the influence of radiation on these detrimental health effects. Various parametric and categorical models (such as linear-no-threshold (LNT) and a number of threshold and step models) were analysed with a statistical selection protocol that rated the model description of the data. Instead of applying the usual approach of identifying one preferred model for each data set, a set of plausible models was applied, and a sub-set of non-nested models was identified that all fitted the data about equally well. Subsequently, this sub-set of non-nested models was used to perform multi-model inference (MMI), an innovative method of mathematically combining different models to allow risk estimates to be based on several plausible dose-response models rather than just relying on a single model of choice. This procedure thereby produces more reliable risk estimates based on a more comprehensive appraisal of model uncertainties. For CVD, MMI yielded a weak dose-response (with a risk estimate of about one-third of the LNT model) below a step at 0.6 Gy and a stronger dose-response at higher doses. The calculated risk estimates are consistent with zero risk below this threshold-dose. For mortalities related to cardiovascular diseases, an LNT-type dose-response was found with risk estimates consistent with zero risk below 2.2 Gy based on 90% confidence intervals. The MMI approach described here resolves a dilemma in practical radiation protection when one is forced to select between models with profoundly different dose-responses for risk estimates.
authors.affiliation: Helmholtz Zentrum München, Department of Radiation Sciences, Institute of Radiation Protection, Neuherberg, Germany. schoellnberger@helmholtz-muenchen.de
authors.forename: H
authors.initials: H
authors.lastname: Schöllnberger
authors.forename: J C
authors.initials: JC
authors.lastname: Kaiser
authors.forename: P
authors.initials: P
authors.lastname: Jacob
authors.forename: L
authors.initials: L
authors.lastname: Walsh
mesh_terms: D020144:Basal Ganglia Cerebrovascular Disease / Q000401:mortality*; D002318:Cardiovascular Diseases / Q000401:mortality*; D003198:Computer Simulation; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D016014:Linear Models; D008297:Male; D009689:Nuclear Warfare; D054043:Nuclear Weapons; D011832:Radiation Injuries / Q000401:mortality*; D018570:Risk Assessment; D017741:Survivors