title: Effects of Pro-Gly-Pro tripeptide on the dopamine system.
abstract: Tripeptide Pro-Gly-Pro interacted with dopamine receptors in vitro and reduced behavioral manifestations of apomorphine-induced hyperfunction of the dopamine system in verticalization, stereotypy, and yawning tests. Presumably, the behavioral effects of Pro-Gly-Pro tripeptide were mediated through post- and presynaptic D(2)and D(3)receptors.
authors.affiliation: Laboratory of Pathophysiology, Center of Mental Health, Russian Academy of Medical Sciences, Moscow, Russia. meshavkin@yandex.ru
authors.forename: V K
authors.initials: VK
authors.lastname: Meshavkin
authors.forename: E Yu
authors.initials: EY
authors.lastname: Batishcheva
authors.forename: N V
authors.initials: NV
authors.lastname: Kost
authors.forename: O Yu
authors.initials: OY
authors.lastname: Sokolov
authors.forename: A V
authors.initials: AV
authors.lastname: Trufanova
authors.forename: G E
authors.initials: GE
authors.lastname: Samonina
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D008297:Male; D051379:Mice; D009842:Oligopeptides / Q000494:pharmacology*; D011392:Proline / Q000031:analogs & derivatives* / Q000494:pharmacology; D017448:Receptors, Dopamine D2 / Q000187:drug effects* / Q000378:metabolism; D050637:Receptors, Dopamine D3 / Q000187:drug effects* / Q000378:metabolism; D013569:Synapses / Q000187:drug effects / Q000378:metabolism
chemical_list: D009842:Oligopeptides; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; C113164:prolyl-glycyl-proline; D011392:Proline