title: Total synthesis of the terpenoid buddledone A: 11-membered ring-closing metathesis.
abstract: The first total synthesis of buddledone A was accomplished in seven steps from methyl ethyl ketone (MEK). The key step in the sequence featured an 11-membered ring formation by ring-closing metathesis.
authors.affiliation: Department of Chemistry, University of Missouri-Columbia, Columbia, Missouri 65211, USA.
authors.forename: Zhengxin
authors.initials: Z
authors.lastname: Cai
authors.forename: Nattawut
authors.initials: N
authors.lastname: Yongpruksa
authors.forename: Michael
authors.initials: M
authors.lastname: Harmata
mesh_terms: D032861:Buddleja / Q000737:chemistry; D002074:Butanones / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D002074:Butanones; D012717:Sesquiterpenes; C572468:buddledone A; C005222:methylethyl ketone