title: The emerging role of IGF-1 deficiency in cardiovascular aging: recent advances.
abstract: This review focuses on cardiovascular protective effects of insulin-like growth factor (IGF)-1, provides a landscape of molecular mechanisms involved in cardiovascular alterations in patients and animal models with congenital and adult-onset IGF-1 deficiency, and explores the link between age-related IGF-1 deficiency and the molecular, cellular, and functional changes that occur in the cardiovascular system during aging. Microvascular protection conferred by endocrine and paracrine IGF-1 signaling, its implications for the pathophysiology of cardiac failure and vascular cognitive impairment, and the role of impaired cellular stress resistance in cardiovascular aging considered here are based on emerging knowledge of the effects of IGF-1 on Nrf2-driven antioxidant response.
authors.affiliation: Reynolds Oklahoma Center on Aging, Department of Geriatric Medicine, University of Oklahoma Health Sciences Center, 975 NE 10th Street, BRC 1303, Oklahoma City, OK 73104, USA. zoltan-ungvari@ouhsc.edu
authors.forename: Zoltan
authors.initials: Z
authors.lastname: Ungvari
authors.forename: Anna
authors.initials: A
authors.lastname: Csiszar
mesh_terms: D000375:Aging / Q000378:metabolism* / Q000502:physiology; D000818:Animals; D002318:Cardiovascular Diseases / Q000378:metabolism* / Q000503:physiopathology; D003072:Cognition Disorders / Q000378:metabolism / Q000503:physiopathology; D004195:Disease Models, Animal; D005260:Female; D006333:Heart Failure / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000172:deficiency*; D046150:Laron Syndrome / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D051379:Mice; D055806:Microvessels / Q000378:metabolism / Q000503:physiopathology; D051267:NF-E2-Related Factor 2 / Q000378:metabolism / Q000502:physiology; D019899:Paracrine Communication / Q000502:physiology; D051381:Rats
chemical_list: D051267:NF-E2-Related Factor 2; D007334:Insulin-Like Growth Factor I