title: Atopic dermatitis causes lipid accumulation in the liver of NC/Nga mouse.
abstract: Various factors have been reported to influence lipid metabolism and cause metabolic syndrome. However, the influence of allergy on the liver that plays important role of lipid metabolism has not been clarified. The aim of this study was to examine the influence of allergy on lipid metabolism of liver. A model of atopic dermatitis was developed in the NC/Nga mouse using picryl chloride to induce allergy. Lipid metabolism parameters were measured and the mechanism of changes in these parameters was examined using DNA microarray analysis and quantitative reverse transcriptase PCR. Triacylglycerol accumulation was promoted in the liver in the mouse atopic dermatitis model despite reductions in food intake, body weight gain, and serum glucose. As this mechanism, it was thought that atopic dermatitis caused the suppression of fatty acid β-oxidation. These results suggest that atopic dermatitis causes lipid accumulation in the liver.
authors.affiliation: Laboratory of Food and Biomolecular Science, Graduate School of Agriculture, Tohoku University, Sendai 981-8555, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Seino
authors.forename: Yurie
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Taro
authors.initials: T
authors.lastname: Honma
authors.forename: Miyuki
authors.initials: M
authors.lastname: Yanaka
authors.forename: Kenta
authors.initials: K
authors.lastname: Sato
authors.forename: Nahoko
authors.initials: N
authors.lastname: Shinohara
authors.forename: Junya
authors.initials: J
authors.lastname: Ito
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Tsuduki
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Nakagawa
authors.forename: Teruo
authors.initials: T
authors.lastname: Miyazawa
authors.forename: Ikuo
authors.initials: I
authors.lastname: Ikeda