title: Asymmetric dimethylarginine: a novel cardiovascular risk factor in end-stage renal disease.
abstract: OBJECTIVE
  This cross-sectional study explored the association between carotid intima-media thickness (CIMT) and the oxidative stress markers asymmetric dimethylarginine (ADMA) and homo cysteine in patients with end-stage renal disease who were on haemodialysis.
  
  
  METHODS
  A total of 30 patients undergoing chronic haemodialysis treatment were recruited to this study. Homocysteine and ADMA levels were determined using a fluorescence polarization immunoassay and an enzyme-linked immunosorbent assay, respectively. CIMT was measured as a marker of atherosclerosis using high-resolution ultrasonography and was performed after haemodialysis.
  
  
  RESULTS
  Significant positive correlations were found between CIMT and ADMA, and CIMT and duration of haemodialysis. Linear regression analysis showed that ADMA level and age were significant independent determinants of CIMT, whereas homo cysteine was not.
  
  
  CONCLUSIONS
  The relationship demonstrated between plasma ADMA and carotid artery thickening suggests that ADMA may be a novel marker of atherosclerosis in patients on haemodialysis.
authors.affiliation: Department of Cardiology and Vascular Medicine, Airlangga University School of Medicine, Jalan Mayjen Prof. Dr Moestopo 6-8, Surabaya 60118, Indonesia. yusuf_505@yahoo.com
authors.forename: M Yusuf
authors.initials: MY
authors.lastname: Alsagaff
authors.forename: M
authors.initials: M
authors.lastname: Thaha
authors.forename: M
authors.initials: M
authors.lastname: Aminuddin
authors.forename: R M
authors.initials: RM
authors.lastname: Yogiarto
authors.forename: M
authors.initials: M
authors.lastname: Yogiantoro
authors.forename: Y
authors.initials: Y
authors.lastname: Tomino
mesh_terms: D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood* / Q000453:epidemiology*; D059168:Carotid Intima-Media Thickness; D003710:Demography; D005260:Female; D006801:Humans; D007214:Indonesia / Q000453:epidemiology; D007676:Kidney Failure, Chronic / Q000097:blood*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D012307:Risk Factors
chemical_list: C018524:N,N-dimethylarginine; D001120:Arginine