title: The recombinant hepatitis B surface antigen vaccine in persons with HIV: is seroconversion sufficient for long-term protection?
abstract: A cohort of human immunodeficiency virus (HIV)-infected individuals with documented vaccine-induced hepatitis B surface antibody (HBsAb) seroconversion was evaluated retrospectively to determine factors associated with loss of protective levels of HBsAb. After a median follow-up of 43 months, 111 of the 152 participants (73%) maintained protective levels of HBsAb. HIV RNA suppression at vaccination was associated with persistence of protective levels of HBsAb (odds ratio, 3.83; P < .01). Booster doses were provided for those with loss of protective antibody levels, and hepatitis B virus-specific immune memory, as evaluated with T-cell proliferation assays, was poor despite the observation that boosters successfully reinduced protective levels of HBsAb.
authors.affiliation: Department of Medicine, University of Toronto, Ontario, Canada. jpowi@tegh.on.ca
authors.forename: Jeff E
authors.initials: JE
authors.lastname: Powis
authors.forename: Janet
authors.initials: J
authors.lastname: Raboud
authors.forename: Mario
authors.initials: M
authors.lastname: Ostrowski
authors.forename: Mona R
authors.initials: MR
authors.lastname: Loutfy
authors.forename: Colin
authors.initials: C
authors.lastname: Kovacs
authors.forename: Sharon L
authors.initials: SL
authors.lastname: Walmsley
mesh_terms: D000328:Adult; D049109:Cell Proliferation; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D015658:HIV Infections / Q000150:complications* / Q000821:virology; D015497:HIV-1; D015498:HIV-2; D006509:Hepatitis B / Q000517:prevention & control* / Q000821:virology; D006510:Hepatitis B Antibodies / Q000097:blood*; D006514:Hepatitis B Surface Antigens / Q000032:analysis / Q000276:immunology*; D017325:Hepatitis B Vaccines / Q000276:immunology*; D006515:Hepatitis B virus / Q000276:immunology*; D006801:Humans; D007117:Immunization, Secondary; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014611:Vaccination; D014614:Vaccines, Synthetic / Q000276:immunology
chemical_list: D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines; D014614:Vaccines, Synthetic