title: T cell trafficking and metabolism: novel mechanisms and targets for immunomodulation.
abstract: Coordinated migratory events by naïve and memory T cells are key to effective immunity. Naïve T cells predominantly recirculate through secondary lymphoid tissue until antigen encounter, while primed T cells efficiently localize to antigen-rich lymphoid and non-lymphoid tissue. Tissue-selective targeting by primed T cells is achieved by a combination of inflammatory signals and tissue-selective homing receptors acquired by T cells during activation and differentiation. A large number of molecular mediators and interactions promoting memory T cell migration to non-lymphoid sites of inflammation have been identified. Recently, additional antigen-driven mechanisms have been proposed, which orchestrate the targeted delivery of memory T cells to antigen-rich tissue. Importantly, recent studies have revealed that the T cell metabolic status influences their differentiation and homing patterns. We here summarize these key observations and discuss their relevance for the manipulation of immune anatomy in therapeutic settings.
authors.affiliation: William Harvey Research Institute - Heart Centre, Barts and The London School of Medicine and Dentistry, Queen Mary - University of London, Charterhouse Square, London EC1M 6BQ, UK.
authors.forename: C
authors.initials: C
authors.lastname: Mauro
authors.forename: H
authors.initials: H
authors.lastname: Fu
authors.forename: F M
authors.initials: FM
authors.lastname: Marelli-Berg
mesh_terms: D000818:Animals; D002465:Cell Movement / Q000276:immunology*; D006801:Humans; D056747:Immunomodulation; D019869:Phosphatidylinositol 3-Kinases / Q000276:immunology; D051057:Proto-Oncogene Proteins c-akt / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D058570:TOR Serine-Threonine Kinases / Q000276:immunology
chemical_list: D019869:Phosphatidylinositol 3-Kinases; D051057:Proto-Oncogene Proteins c-akt; D011948:Receptors, Antigen, T-Cell; D058570:TOR Serine-Threonine Kinases