title: Structural and functional aspects of winged-helix domains at the core of transcription initiation complexes.
abstract: The winged helix (WH) domain is found in core components of transcription systems in eukaryotes and prokaryotes. It represents a sub-class of the helix-turn-helix motif. The WH domain participates in establishing protein-DNA and protein-protein-interactions. Here, we discuss possible explanations for the enrichment of this motif in transcription systems.
authors.affiliation: Université de Bordeaux, Institut Européen de Chimie et Biologie, Pessac, France.
authors.forename: Martin
authors.initials: M
authors.lastname: Teichmann
authors.forename: Hélène
authors.initials: H
authors.lastname: Dumay-Odelot
authors.forename: Sébastien
authors.initials: S
authors.lastname: Fribourg
mesh_terms: D004247:DNA / Q000737:chemistry / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000737:chemistry* / Q000378:metabolism; D012321:DNA-Directed RNA Polymerases / Q000737:chemistry* / Q000378:metabolism; D019077:Helix-Turn-Helix Motifs; D006801:Humans; D017434:Protein Structure, Tertiary; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins / Q000737:chemistry / Q000378:metabolism; D014157:Transcription Factors / Q000737:chemistry* / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D004268:DNA-Binding Proteins; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; D004247:DNA; D012321:DNA-Directed RNA Polymerases