title: Lethal mutagenesis of viruses.
abstract: Lethal mutagenesis aims at extinguishing viruses by increased mutagenesis prompted by virus-specific mutagenic agents, mainly nucleoside analogues. It is derived from the error threshold relationship of quasispecies theory, and it is slowly finding its way towards a clinical application. We summarize the current situation of research in this field of antiviral therapy.
authors.affiliation: Centro de Biología Molecular Severo Ochoa (CSIC-UAM), Consejo Superior de Investigaciones Científicas, Campus de Cantoblanco, 28049, Madrid, Spain.
authors.forename: Celia
authors.initials: C
authors.lastname: Perales
authors.forename: Verónica
authors.initials: V
authors.lastname: Martín
authors.forename: Esteban
authors.initials: E
authors.lastname: Domingo
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000633:toxicity*; D006801:Humans; D016296:Mutagenesis; D009153:Mutagens / Q000633:toxicity*; D014777:Virus Diseases / Q000188:drug therapy / Q000821:virology*; D014780:Viruses / Q000187:drug effects / Q000235:genetics*
chemical_list: D000998:Antiviral Agents; D009153:Mutagens