title: Number of persistent organic pollutants detected at high concentrations in a general population.
abstract: BACKGROUND
  Surveys of human exposure to environmental chemicals do not integrate the number of compounds detected per person and the concentration of each compound. This leaves untested relevant exposure scenarios, such as whether individuals with low concentrations of some compounds have high concentrations of the other compounds.
  
  
  OBJECTIVE
  To analyze the number of persistent organic pollutants (POPs) detected at high concentrations.
  
  
  METHODS
  Serum concentrations of 19 POPs were analyzed by gas chromatography with electron-capture detection in a representative sample of the general population of Catalonia, Spain (N=919).
  
  
  RESULTS
  Over 58% of participants had concentrations in the top quartile of ≥1 of the eight most prevalent POPs, and 34% of ≥3 POPs. 83% of women 60 to 74 years old had concentrations of ≥3 POPs in the top quartile; 56% of women 60 to 74 years had p,p'-DDE, HCB and β-HCH all in their respective top quartiles, and 48% had concentrations of ≥6 POPs in the top quartile. Over 30% of subjects had concentrations in the top decile of 1 to 5 of the eight most prevalent POPs. Half of the population had levels of 1 to 5 POPs >500 ng/g. Less than 4% had all eight POPs in the lowest quartile.
  
  
  CONCLUSIONS
  More than half of the study population had concentrations in the top quartile of ≥1 POPs. Significant subgroups of the population accumulate POP mixtures at high concentrations. POP concentrations appear low in most of the population only when each individual compound is looked at separately.
authors.affiliation: Hospital del Mar Research Institute-IMIM, Barcelona, Spain; School of Medicine, Universitat Autònoma de Barcelona, Spain. mporta@imim.es
authors.forename: Miquel
authors.initials: M
authors.lastname: Porta
authors.forename: José
authors.initials: J
authors.lastname: Pumarega
authors.forename: Magda
authors.initials: M
authors.lastname: Gasull
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003633:Dichlorodiphenyl Dichloroethylene / Q000032:analysis / Q000097:blood; D004781:Environmental Exposure / Q000032:analysis / Q000706:statistics & numerical data*; D004785:Environmental Pollutants / Q000032:analysis / Q000097:blood*; D004787:Environmental Pollution / Q000706:statistics & numerical data*; D005260:Female; D006581:Hexachlorobenzene / Q000032:analysis / Q000097:blood; D001556:Hexachlorocyclohexane / Q000032:analysis / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D013030:Spain; D055815:Young Adult
chemical_list: D004785:Environmental Pollutants; D003633:Dichlorodiphenyl Dichloroethylene; D006581:Hexachlorobenzene; D001556:Hexachlorocyclohexane; C023888:beta-hexachlorocyclohexane