title: Role of oxidative stress in the clinical outcome of patients with multiple blunt trauma.
abstract: OBJECTIVE
  This prospective study evaluated serum total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI), along with the Revised Trauma Score (RTS) and Injury Severity Score (ISS), as predictors of clinical outcome in the early post-traumatic period  in patients with multiple blunt trauma (MBT).
  
  
  METHODS
  The study included 52 patients admitted to the emergency department with MBT and 40 age- and sex-matched healthy control subjects.
  
  
  RESULTS
  The overall MBT patient mortality was 32.7% (17/52). There was no significant association between  age and mortality in MBT patients, but there was a negative correlation between mortality and RTS, and a positive correlation between mortality and ISS. TOS levels were significantly higher in nonsurvivors compared with survivors. There was no correlation between TAS or OSI and survival. ISS  and RTS showed positive and negative correlations with TOS level, respectively, but neither was significantly related to TAS or OSI.
  
  
  CONCLUSIONS
  These findings suggest that TOS, as an early oxidative stress biomarker, may be an objective alternative criterion to the ISS and RTS for managing  patients with MBT during the early period following traumatic injury.
authors.affiliation: Department of Emergency Medicine, Faculty of Medicine, Harran University, Sanliurfa, Turkey.
authors.forename: M T
authors.initials: MT
authors.lastname: Gokdemir
authors.forename: O
authors.initials: O
authors.lastname: Sogut
authors.forename: H
authors.initials: H
authors.lastname: Kaya
authors.forename: M B
authors.initials: MB
authors.lastname: Sayhan
authors.forename: M
authors.initials: M
authors.lastname: Cevik
authors.forename: M A
authors.initials: MA
authors.lastname: Dokuzoglu
authors.forename: M E
authors.initials: ME
authors.lastname: Boleken
mesh_terms: D000375:Aging / Q000473:pathology; D016022:Case-Control Studies; D003710:Demography; D004636:Emergency Service, Hospital; D005260:Female; D006801:Humans; D008297:Male; D009104:Multiple Trauma / Q000150:complications* / Q000473:pathology*; D018384:Oxidative Stress; D017741:Survivors; D016896:Treatment Outcome; D014949:Wounds, Nonpenetrating / Q000150:complications* / Q000473:pathology*; D055815:Young Adult