title: Bowel preparation with polyethylene glycol electrolyte solution: optimizing the splitting regimen.
abstract: OBJECTIVE
  Quality of bowel cleansing significantly increases the shorter the time between bowel solution intake and endoscopic examination. We tested the efficacy and patient tolerability following a modified polyethylene glycol electrolyte (PEG) splitting regimen.
  
  
  METHODS
  This was a prospective, single-blind, randomized, study. Patients were assigned to receive either PEG 4 L the afternoon before colonoscopy or PEG 3 L the day before and 1 L 3h before the procedure the day of colonoscopy.
  
  
  RESULTS
  The study population consisted of 336 patients, including 168 participants in each study arm. Although the bowel preparation quality was similarly quoted as excellent/good following the split and full regimen (95.2% vs 92.8%; p=0.3), a significant (p<0.0001) shift from good towards an excellent preparation (26.8% vs 68.4%) was observed following the split regimen as compared to the full regimen (55.4% vs 37.5%). The incidence of side-effects did not differ. When patients were asked about a future preparation if needed, 69% and 31% following the split and full regimen, respectively, declared to accept again the same preparation, the difference being statistically significant (p<0.001).
  
  
  CONCLUSIONS
  Our data found that an excellent bowel cleansing could be frequently achieved by simply modifying the split regimen from the standard PEG 2 plus 2 L to 3 plus 1 L.
authors.affiliation: Gastroenterology and Digestive Endoscopy Unit, Nuovo Ospedale Civile S.Agostino-Estense - Baggiovara di Modena, Modena, Italy. m.manno@ausl.mo.it
authors.forename: Mauro
authors.initials: M
authors.lastname: Manno
authors.forename: Flavia
authors.initials: F
authors.lastname: Pigò
authors.forename: Raffaele
authors.initials: R
authors.lastname: Manta
authors.forename: Carmelo
authors.initials: C
authors.lastname: Barbera
authors.forename: Helga
authors.initials: H
authors.lastname: Bertani
authors.forename: Vincenzo Giorgio
authors.initials: VG
authors.lastname: Mirante
authors.forename: Emanuele
authors.initials: E
authors.lastname: Dabizzi
authors.forename: Angelo
authors.initials: A
authors.lastname: Caruso
authors.forename: Gianpiero
authors.initials: G
authors.lastname: Olivetti
authors.forename: Cesare
authors.initials: C
authors.lastname: Hassan
authors.forename: Angelo
authors.initials: A
authors.lastname: Zullo
authors.forename: Rita
authors.initials: R
authors.lastname: Conigliaro
mesh_terms: D000368:Aged; D002400:Cathartics / Q000008:administration & dosage* / Q000009:adverse effects; D016009:Chi-Square Distribution; D003113:Colonoscopy / Q000379:methods*; D004573:Electrolytes / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D057240:Patient Preference; D011092:Polyethylene Glycols / Q000008:administration & dosage* / Q000009:adverse effects; D016037:Single-Blind Method; D013997:Time Factors
chemical_list: D002400:Cathartics; D004573:Electrolytes; D011092:Polyethylene Glycols