title: IDH1 mutation in pediatric gliomas: has it a diagnostic and prognostic value?
abstract: Mutations in IDH1 gene are observed in gliomas with significant differences according to histotype, grade, prognosis, and age. We analyzed the IDH1 gene mutations frequency in 42 gliomas from 40 children (14 pilocytic astrocytomas; 3 pilomyxoid astrocytomas; 3 diffuse astrocytomas; 1 gliomatosi cerebri; 8 subependymal giant cell astrocytomas; 2 anaplastic astrocytomas; 9 glioblastomas). No IDH1 mutation was detected. Our results indicate that there is no IDH1 gene involvement in the onset and progression of pediatric astrocytomas. We argue that it is not useful in children to assess the status of IDH1 gene nor for diagnostic nor prognostic purposes.
authors.affiliation: Pathology Unit, Anna Meyer Children's Hospital, Florence, Italy. ambuccoliero@unifi.it
authors.forename: Anna Maria
authors.initials: AM
authors.lastname: Buccoliero
authors.forename: Francesca
authors.initials: F
authors.lastname: Castiglione
authors.forename: Duccio Rossi
authors.initials: DR
authors.lastname: Degl'Innocenti
authors.forename: Chiara Francesca
authors.initials: CF
authors.lastname: Gheri
authors.forename: Lorenzo
authors.initials: L
authors.lastname: Genitori
authors.forename: Gian Luigi
authors.initials: GL
authors.lastname: Taddei
mesh_terms: D000293:Adolescent; D001254:Astrocytoma / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D001932:Brain Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D004252:DNA Mutational Analysis; D018450:Disease Progression; D006801:Humans; D007223:Infant; D007521:Isocitrate Dehydrogenase / Q000235:genetics* / Q000378:metabolism; D009154:Mutation; D012189:Retrospective Studies
chemical_list: D014408:Biomarkers, Tumor; D007521:Isocitrate Dehydrogenase; C543588:IDH1 protein, human