title: Melanogenesis inhibitory bisabolane-type sesquiterpenoids from the roots of Angelica koreana.
abstract: Bioactivity-guided isolation of the methanolic extract of the roots of Angelica koreana led to the isolation of four new bisabolane-type sesquiterpenoids, osterivolones A-D (1-4) together with four known compounds, bisabolangelone (5), decursinol angelate (6), psoralen (7), and falcarindiol (8). Their structures were elucidated on the basis of spectroscopic data interpretation, especially 2D NMR spectra such as HMQC, HMBC, and NOESY. All compounds were evaluated for their inhibitory effects of the melanogenesis against α-melanocyte stimulating hormone (α-MSH)-activated B16 melanoma cells.
authors.affiliation: College of Pharmacy, Chungbuk National University, Cheongju 361-763, Republic of Korea.
authors.forename: Jin Woo
authors.initials: JW
authors.lastname: Lee
authors.forename: Cheong-Yong
authors.initials: CY
authors.lastname: Yun
authors.forename: Eunmiri
authors.initials: E
authors.lastname: Roh
authors.forename: Chul
authors.initials: C
authors.lastname: Lee
authors.forename: Qinghao
authors.initials: Q
authors.lastname: Jin
authors.forename: Kwon Ki
authors.initials: KK
authors.lastname: Bang
authors.forename: Sang-Hun
authors.initials: SH
authors.lastname: Jung
authors.forename: Dongho
authors.initials: D
authors.lastname: Lee
authors.forename: Mi Kyeong
authors.initials: MK
authors.lastname: Lee
authors.forename: Youngsoo
authors.initials: Y
authors.lastname: Kim
authors.forename: Bang Yeon
authors.initials: BY
authors.lastname: Hwang
mesh_terms: D029969:Angelica / Q000737:chemistry*; D045744:Cell Line, Tumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008543:Melanins / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D015394:Molecular Structure; D010936:Plant Extracts / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D008543:Melanins; D010936:Plant Extracts; D012717:Sesquiterpenes; C455067:bisabolangelone