title: The impact in older women of ovarian FMR1 genotypes and sub-genotypes on ovarian reserve.
abstract: We recently associated ovarian FMR1genotypes and sub-genotypes with distinct ovarian aging patterns. How they impact older females is, however, unknown. We, therefore, investigated 217 consecutive first in vitro fertilization (IVF) cycles in women >40 assessing oocyte yields, stratified for better (anti-Müllerian hormone, AMH >1.05 ng/mL) or poorer (AMH ≤ 1.05 ng/mL) functional reserve (FOR)). Mean age was 42.4 ± 2.0 years, mean AMH 0.76 ± 0.92 ng/mL and mean oocyte yield 5.3 ± 5.4. Overall, and in women with better FOR, FMR1 did not affect oocyte yields. With poorer FOR (AMH ≤ 1.05 ng/mL) women with het-norm/high, however, demonstrated higher oocyte yields (5.0 ± 3.8) than those with het-norm/low sub-genotype 3.1 ± 2.5; P = 0.03), confirmed after log conversion. Known associated with low FOR at young age, het-norm/high, thus, appears to preserve FOR into older age, and both het sub-genotypes appear to expand female reproductive lifespan into opposite directions.
authors.affiliation: Center for Human Reproduction and Foundation for Reproductive Medicine, New York, New York, United States of America. ngleicher@thechr.com
authors.forename: Norbert
authors.initials: N
authors.lastname: Gleicher
authors.forename: Andrea
authors.initials: A
authors.lastname: Weghofer
authors.forename: Ann
authors.initials: A
authors.lastname: Kim
authors.forename: David H
authors.initials: DH
authors.lastname: Barad
mesh_terms: D000328:Adult; D000375:Aging / Q000235:genetics* / Q000502:physiology*; D054304:Anti-Mullerian Hormone / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro; D051860:Fragile X Messenger Ribonucleoprotein 1 / Q000235:genetics*; D005838:Genotype; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D009865:Oocytes / Q000166:cytology; D010050:Ovarian Function Tests; D010053:Ovary / Q000166:cytology / Q000502:physiology*; D011247:Pregnancy
chemical_list: D054304:Anti-Mullerian Hormone; D051860:Fragile X Messenger Ribonucleoprotein 1; C497683:FMR1 protein, human