title: Mycotic aneurysm and subarachnoid hemorrhage following tubercular meningitis in an infant with congenital tuberculosis and cytomegalovirus disease.
abstract: We describe autopsy findings in a 5-month-old infant with disseminated tuberculosis and congenital cytomegalovirus disease. The infant manifested with tubercular meningitis complicating as ruptured mycotic right middle cerebral artery aneurysm. Infiltrative, proliferative, and necrotizing vascular pathologies have been described; however, the occurrence of these is dependent on the duration of illness. The vessel pathology appears to be a payback of its immersion in the local inflammatory cell-rich exudates. Strokes early in the course of the disease are believed to be a consequence of vasospasm, and those occurring later during the disease course are due to proliferative intimal disease. Intracranial mycotic aneurysm following tubercular meningitis developing at such a young age has not been reported in the literature. The lung lesions in a congenitally transmitted tuberculosis and cytomegalovirus disease have also been elaborated.
authors.affiliation: Departments of Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India. kirtigupta10@yahoo.co.in
authors.forename: Kirti
authors.initials: K
authors.lastname: Gupta
authors.forename: Bishan Dass
authors.initials: BD
authors.lastname: Radotra
authors.forename: Deepti
authors.initials: D
authors.lastname: Suri
authors.forename: Kusum
authors.initials: K
authors.lastname: Sharma
authors.forename: Akshay Kumar
authors.initials: AK
authors.lastname: Saxena
authors.forename: Pratibha
authors.initials: P
authors.lastname: Singhi
mesh_terms: D000785:Aneurysm, Infected / Q000209:etiology* / Q000473:pathology; D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D002540:Cerebral Cortex / Q000473:pathology / Q000821:virology; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000473:pathology; D005260:Female; D006801:Humans; D007223:Infant; D013345:Subarachnoid Hemorrhage / Q000209:etiology* / Q000473:pathology; D014390:Tuberculosis, Meningeal / Q000150:complications* / Q000473:pathology; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; C067980:CD68 antigen, human; D000097382:CD68 Molecule