title: Endogenous granulocyte colony-stimulating factor: a biomarker in acute ischemic stroke.
abstract: Granulocyte colony-stimulating factor (G-CSF) may protect ischemic brain injury either in animal or human. No studies have reported that endogenous G-CSF (enG-CSF) level is related to the severity of ischemic stroke. This study was designed to assess the severity of ischemic patients correlated with the alteration of enG-CSF on the 1st day after an ischemic event. Patient's plasma enG-CSF and scoring of National Institute of Health Stroke Scale were measured on the 1st day after ischemic stroke. The acute ischemic stroke could significantly induce enG-GCF secretion as compared with healthy control group (16.77 vs. 22.86 μg/L, p = 0.001). Elevated enG-CSF concentration was positively correlated with the severity of stroke patients on day 1 after the event (p = 0.006; Spearman correlation coefficient = 0.268). The enG-CSF is a good biomarker for prediction of severity of acute ischemic stroke.
authors.affiliation: Department of Neurology, Kuang-Tien General Hospital, Taichung, Taiwan.
authors.forename: Shih-Chieh
authors.initials: SC
authors.lastname: Yu
authors.forename: Chen-Ling
authors.initials: CL
authors.lastname: Kuo
authors.forename: Ching-Shan
authors.initials: CS
authors.lastname: Huang
authors.forename: Cheng-Shu
authors.initials: CS
authors.lastname: Chang
authors.forename: Shey-Lin
authors.initials: SL
authors.lastname: Wu
authors.forename: Shih-Li
authors.initials: SL
authors.lastname: Su
authors.forename: Chin-San
authors.initials: CS
authors.lastname: Liu
mesh_terms: D000208:Acute Disease; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D002545:Brain Ischemia / Q000097:blood* / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000097:blood*; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric
chemical_list: D015415:Biomarkers; D016179:Granulocyte Colony-Stimulating Factor