title: Chromium picolinate modulates serotonergic properties and carbohydrate metabolism in a rat model of diabetes.
abstract: Chromium picolinate (CrPic) has shown both antidepressant and antidiabetic properties. In this study, the effects of CrPic on serotonergic properties and carbohydrate metabolism in diabetic rats were evaluated. Sixty male Sprague-Dawley rats were divided into four groups. (1) The control group received only standard diet (8 % fat). (2) The CrPic group was fed standard diet and CrPic (80 μg CrPic per kilogram body mass (b.m.)/day), for 10 weeks (microgram/kilogram b.m./day). (3) The HFD/STZ group fed a high-fat diet (HFD, 40 % fat) for 2 weeks and then received streptozotocin (STZ, 40 mg/kg, i.p.) (i.v.) HFD-STZ-CrPic group treated as the previous group and then were administered CrPic. CrPic administration to HFD/STZ-treated rats increased brain chromium levels and improved all measurements of carbohydrate metabolism and serotonergic properties (P<0.001). CrPic also significantly increased levels of insulin, tryptophan, and serotonin (P<0.001) in the serum and brain, and decreased cortisol levels in the serum (P<0.01). Except chromium levels, no significant effect of CrPic supplementation was detected on the overall measured parameters in the control group. CrPic administration was well tolerated without any adverse events. The results support the use of CrPic supplementation which improves serotonergic properties of brain in diabetes.
authors.affiliation: Technical Services and Scientific Affairs, Nutrition 21, Inc., Purchase, NY, USA.
authors.forename: James R
authors.initials: JR
authors.lastname: Komorowski
authors.forename: Mehmet
authors.initials: M
authors.lastname: Tuzcu
authors.forename: Nurhan
authors.initials: N
authors.lastname: Sahin
authors.forename: Vijaya
authors.initials: V
authors.lastname: Juturu
authors.forename: Cemal
authors.initials: C
authors.lastname: Orhan
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ulas
authors.forename: Kazim
authors.initials: K
authors.lastname: Sahin
mesh_terms: D000818:Animals; D001835:Body Weight; D001921:Brain / Q000378:metabolism; D050260:Carbohydrate Metabolism; D002857:Chromium / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism*; D059305:Diet, High-Fat / Q000009:adverse effects; D019587:Dietary Supplements; D004353:Drug Evaluation, Preclinical; D006854:Hydrocortisone / Q000097:blood; D007328:Insulin / Q000097:blood / Q000378:metabolism; D008297:Male; D010848:Picolinic Acids / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D012701:Serotonin / Q000097:blood / Q000378:metabolism; D018490:Serotonin Agents / Q000494:pharmacology*; D013311:Streptozocin / Q000009:adverse effects; D014364:Tryptophan / Q000097:blood / Q000378:metabolism
chemical_list: D007328:Insulin; D010848:Picolinic Acids; D018490:Serotonin Agents; D002857:Chromium; D012701:Serotonin; D013311:Streptozocin; D014364:Tryptophan; C030614:picolinic acid; D006854:Hydrocortisone