title: Synthesis of carotenoid-cysteine conjugates.
abstract: Isozeaxanthin under acidic conditions forms an allylic cation which reacts readily with thiol nucleophiles. With N-acetylcysteine as a nucleophile the products obtained are carotenoid-cysteine conjugates in which the amino acid moiety is attached to the carotenoid via sulphur in position 4. The water solubility of the products can be increased by deprotection of the amino group. The antioxidant activity of the products were examined on human liver cells under conditions of hydrogen-peroxide induced oxidative stress.
authors.affiliation: Department of Biochemistry and Medical Chemistry, Medical School, University of Pécs, Hungary.
authors.forename: Afshin
authors.initials: A
authors.lastname: Zand
authors.forename: Attila
authors.initials: A
authors.lastname: Agócs
authors.forename: József
authors.initials: J
authors.lastname: Deli
authors.forename: Veronika
authors.initials: V
authors.lastname: Nagy
mesh_terms: D002338:Carotenoids / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D002460:Cell Line; D003545:Cysteine / Q000737:chemistry*; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D015394:Molecular Structure; D018384:Oxidative Stress / Q000187:drug effects; D012995:Solubility
chemical_list: D002338:Carotenoids; D006861:Hydrogen Peroxide; D003545:Cysteine