title: The value of eliminating foods according to food-specific immunoglobulin G antibodies in irritable bowel syndrome with diarrhoea.
abstract: OBJECTIVE
  This study investigated the role of food intolerance in irritable bowel syndrome with diarrhoea (D-IBS).
  
  
  METHODS
  Specific immunoglobulin G (IgG) antibodies against 14 common food antigens in the serum were measured in 77 patients with D-IBS and 26 healthy controls. Food-specific  IgG antibodies were identified in 39 (50.65%) patients with D-IBS patients compared with four (15.38%) controls. For 12 weeks following the serological testing, 35 patients with D-IBS and food intolerance consumed diets that excluded the identified food. Changes in the main symptoms of D-IBS  were evaluated before treatment and regularly during treatment in these patients.
  
  
  RESULTS
  After 4 weeks' dietary therapy, most symptoms of D-IBS had improved. By 12 weeks, all symptom scores had decreased significantly compared with the baseline scores.
  
  
  CONCLUSIONS
  The 12-week specific-food  exclusion diets resulted in significant improvements in abdominal pain (bloating level and frequency), diarrhoea frequency, abdominal distension, stool shape, general feelings of distress and total symptom score compared with baseline in patients with D-IBS.
authors.affiliation: Department of Gastroenterology, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Guo
authors.forename: Tao
authors.initials: T
authors.lastname: Jiang
authors.forename: Jinliang
authors.initials: J
authors.lastname: Wang
authors.forename: Yongchao
authors.initials: Y
authors.lastname: Chang
authors.forename: Hai
authors.initials: H
authors.lastname: Guo
authors.forename: Weihong
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000918:Antibody Specificity / Q000276:immunology*; D016022:Case-Control Studies; D003967:Diarrhea / Q000097:blood / Q000150:complications / Q000276:immunology*; D004032:Diet; D005260:Female; D005502:Food / Q000009:adverse effects*; D005512:Food Hypersensitivity / Q000097:blood / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D043183:Irritable Bowel Syndrome / Q000097:blood / Q000150:complications / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D007074:Immunoglobulin G