title: Cognitive performance related to HIV-1-infected monocytes.
abstract: The effect that HIV type 1 (HIV) has on neurocognition is a dynamic process whereby peripheral events are likely involved in setting the stage for clinical findings. In spite of antiretroviral therapy (ART), patients continue to be at risk for HIV-associated neurocognitive disorders (HAND), which might be related to persistence of inflammation. In a yearly assessment of HIV DNA levels in activated monocytes, increased HIV DNA copies were found in patients with persistent HAND. Furthermore, activated monocytes from patients with high HIV DNA copies secreted more inflammatory cytokines. Since these activated monocytes traffic to the CNS and enter the brain, they may contribute to an inflammatory environment in the CNS that leads to HAND.
authors.affiliation: Hawaii Center for AIDS, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI, USA.
authors.forename: Ian
authors.initials: I
authors.lastname: Kusao
authors.forename: Bruce
authors.initials: B
authors.lastname: Shiramizu
authors.forename: Chin-Yuan
authors.initials: CY
authors.lastname: Liang
authors.forename: John
authors.initials: J
authors.lastname: Grove
authors.forename: Melissa
authors.initials: M
authors.lastname: Agsalda
authors.forename: David
authors.initials: D
authors.lastname: Troelstrup
authors.forename: Van-Nicholas
authors.initials: VN
authors.lastname: Velasco
authors.forename: Andrew
authors.initials: A
authors.lastname: Marshall
authors.forename: Nicholas
authors.initials: N
authors.lastname: Whitenack
authors.forename: Cecilia
authors.initials: C
authors.lastname: Shikuma
authors.forename: Victor
authors.initials: V
authors.lastname: Valcour
mesh_terms: D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000378:metabolism; D000945:Antigens, Differentiation, T-Lymphocyte / Q000378:metabolism; D003072:Cognition Disorders / Q000209:etiology* / Q000821:virology*; D015331:Cohort Studies; D004267:DNA Viruses / Q000378:metabolism; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000473:pathology*; D054298:Human Immunodeficiency Virus Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D009483:Neuropsychological Tests
chemical_list: D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; C062279:CD6 antigen; D054298:Human Immunodeficiency Virus Proteins