title: Taurine and glutathione levels in plasma before and after ECT treatment.
abstract: Taurine has been shown to be elevated in plasma and lymphocytes of depressed patients, but the level normalises after successful drug therapy. During depression, levels of glutathione (GSH) are decreased in the plasma and blood. This study was performed to examine taurine and GSH levels in depressed patients before and after electroconvulsive therapy (ECT). Fasting blood samples were collected from 23 patients before the first and after the third ECT treatment. The severity of depression was estimated with the Montgomery-Åsberg Depression Rating Scale (MADRS). We analysed GSH in blood and the levels of taurine and total GSH in plasma. After three ECTs, a significant decrease in MADRS scores was found for the entire group. Simultaneously, the decrease in the plasma taurine levels was significant for the seven responders but not for the sixteen non-responders. We observed no differences in blood or plasma GSH levels after three ECT treatments when compared to values before the therapy. Plasma taurine levels decrease significantly after three ECT treatments in patients who respond to treatment. GSH levels were not affected by ECT treatment. The results indicate that taurine may play a role in the pathophysiology of depression.
authors.affiliation: Psychiatry, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköpings University, Linköping, Sweden. martin.samuelsson@lio.se
authors.forename: Martin
authors.initials: M
authors.lastname: Samuelsson
authors.forename: George
authors.initials: G
authors.lastname: Gerdin
authors.forename: Karin
authors.initials: K
authors.lastname: Ollinger
authors.forename: Magnus
authors.initials: M
authors.lastname: Vrethem
mesh_terms: D000328:Adult; D000368:Aged; D002851:Chromatography, High Pressure Liquid; D003863:Depression / Q000097:blood* / Q000628:therapy*; D004565:Electroconvulsive Therapy / Q000379:methods*; D005260:Female; D005978:Glutathione / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018962:Phlebotomy / Q000379:methods; D011569:Psychiatric Status Rating Scales; D018709:Statistics, Nonparametric; D013654:Taurine / Q000097:blood*; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D013654:Taurine; D005978:Glutathione