title: Potent divalent inhibitors with rigid glucose click spacers for Pseudomonas aeruginosa lectin LecA.
abstract: The synthesis of a new rigid spacer based on carbohydrate-triazole repeating units and their incorporation into divalent systems is described. Inhibition studies showed that a well-matched system with a rigid spacer with flexible ends leads to the most potent inhibition of Pseudomonas aeruginosa lectin LecA.
authors.affiliation: Department of Medicinal Chemistry and Chemical Biology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, P.O. Box 80082, 3508 TB Utrecht, The Netherlands.
authors.forename: Francesca
authors.initials: F
authors.lastname: Pertici
authors.forename: Roland J
authors.initials: RJ
authors.lastname: Pieters
mesh_terms: D018829:Adhesins, Bacterial / Q000378:metabolism*; D057930:Click Chemistry; D015195:Drug Design; D005947:Glucose / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D011550:Pseudomonas aeruginosa
chemical_list: D018829:Adhesins, Bacterial; C102929:LecA protein, bacteria; D005947:Glucose