title: Correction of furosemide-induced magnesium deficiency with different stereoisomers of organic magnesium salts: a comparative study.
abstract: We compared the efficiency of different stereoisomers of organic magnesium salts (Mg DL-, Mg D-, and Mg L-aspartate and Mg L- and Mg DL-glutamate) after oral administration under conditions of furosemide-induced magnesium deficiency. The time to complete compensation of erythrocyte magnesium level was 5 days for Mg L-aspartate, 10 and 8 days for Mg L-glutamate and Mg D-aspartate, respectively, and 11 days for Mg DL-aspartate and Mg DL-glutamate. These findings attest to better bioavailability of Mg complex with L-stereoisomer of aspartate in comparison with DL and D-stereoisomers and stereoisomers of Mg glutamate.
authors.affiliation: Department of Pharmacology, Research Institute of Pharmacology, Volgograd State Medical University, Russia. farm@vlpost.ru
authors.forename: A A
authors.initials: AA
authors.lastname: Spasov
authors.forename: A A
authors.initials: AA
authors.lastname: Ozerov
authors.forename: I N
authors.initials: IN
authors.lastname: Iezhitsa
authors.forename: M V
authors.initials: MV
authors.lastname: Kharitonova
authors.forename: M S
authors.initials: MS
authors.lastname: Kravchenko
authors.forename: A A
authors.initials: AA
authors.lastname: Zheltova
mesh_terms: D000818:Animals; D001224:Aspartic Acid / Q000008:administration & dosage / Q000494:pharmacology; D005665:Furosemide / Q000633:toxicity*; D008274:Magnesium / Q000008:administration & dosage / Q000494:pharmacology*; D017616:Magnesium Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D008275:Magnesium Deficiency / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D051381:Rats; D013237:Stereoisomerism
chemical_list: D017616:Magnesium Compounds; D001224:Aspartic Acid; D005665:Furosemide; D008274:Magnesium