title: Oxidative stress resistance in Porphyromonas gingivalis.
abstract: Porphyromonas gingivalis, a black-pigmented, Gram-negative anaerobe, is an important etiologic agent of periodontal disease. The harsh inflammatory condition of the periodontal pocket implies that this organism has properties that will facilitate its ability to respond and adapt to oxidative stress. Because the stress response in the pathogen is a major determinant of its virulence, a comprehensive understanding of its oxidative stress resistance strategy is vital. We discuss multiple mechanisms and systems that clearly work in synergy to defend and protect P. gingivalis against oxidative damage caused by reactive oxygen species. The involvement of multiple hypothetical proteins and/or proteins of unknown function in this process may imply other unique mechanisms and potential therapeutic targets.
authors.affiliation: Division of Microbiology & Molecular Genetics, School of Medicine, Loma Linda, CA 92350, USA.
authors.forename: Leroy G
authors.initials: LG
authors.lastname: Henry
authors.forename: Rachelle M E
authors.initials: RM
authors.lastname: McKenzie
authors.forename: Antonette
authors.initials: A
authors.lastname: Robles
authors.forename: Hansel M
authors.initials: HM
authors.lastname: Fletcher
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D018384:Oxidative Stress; D010510:Periodontal Diseases / Q000378:metabolism / Q000382:microbiology*; D016966:Porphyromonas gingivalis / Q000235:genetics / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D017382:Reactive Oxygen Species