title: Cognitex supplementation in elderly adults with memory complaints: an uncontrolled open label trial.
abstract: BACKGROUND
  The components of the nutritional supplement Cognitex have been individually shown to have beneficial effects on cognitive function. We evaluated the efficacy of the nutritional supplement in improving cognitive function in elderly with memory complaints.
  
  
  METHODS
  Thirty participants received three capsules of the nutritional supplement per day for 12 weeks in an open label study. Efficacy and safety measures, assessed at baseline, 2 weeks, and 12 weeks of treatment, included cognitive evaluation using a computerized cognitive assessment tool, vital signs measurements, and physical examination.
  
  
  RESULTS
  Twenty-six participants completed the 12-week study. A significant improvement in memory abilities (recall, recognition, and spatial short term) was observed following 2 weeks of Cognitex treatment (mean change from baseline: 11.15 ± 2.90, 8.68 ± 2.50, and 19.85 ± 6.19, respectively). Attention (sustained and focused), visual learning, and activities of daily living (executive functions and mental flexibility) were improved as well following this short supplementation period (mean change from baseline: 9.46 ± 3.80, 3.76 ± 1.50, 17.31 ± 5.33, 9.45 ± 3.73, and 9.92 ± 4.08, respectively). After 10 additional treatment weeks, activities of daily living demonstrated an additional statistically significant improvement while the beneficial effect observed for the rest of the tested parameters remained unchanged.
  
  
  CONCLUSIONS
  The results indicate that the nutritional supplement may improve cognitive performance in elderly with memory complaints; however, further blinded and placebo-controlled studies are needed.
  
  
  BACKGROUND
  Clinicaltrials.gov, Identifier: NCT00719953.
authors.affiliation: Department of Research & Development, Enzymotec Ltd., Migdal HaEmek, Israel. yaelr@enzymotec.com
authors.forename: Yael
authors.initials: Y
authors.lastname: Richter
authors.forename: Yael
authors.initials: Y
authors.lastname: Herzog
authors.forename: Inbal
authors.initials: I
authors.lastname: Eyal
authors.forename: Tzafra
authors.initials: T
authors.lastname: Cohen
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D001288:Attention / Q000187:drug effects; D003071:Cognition / Q000187:drug effects*; D019587:Dietary Supplements; D056344:Executive Function / Q000187:drug effects; D015525:Fatty Acids, Omega-3 / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D020404:Glycerophospholipids / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008055:Lipids / Q000627:therapeutic use*; D019684:Magnoliopsida; D008297:Male; D008568:Memory / Q000187:drug effects; D008569:Memory Disorders / Q000188:drug therapy*; D018697:Nootropic Agents / Q000494:pharmacology / Q000627:therapeutic use; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D014542:Uridine Monophosphate / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D015525:Fatty Acids, Omega-3; D020404:Glycerophospholipids; D008055:Lipids; D018697:Nootropic Agents; D010936:Plant Extracts; D014542:Uridine Monophosphate