title: Heart rate is associated with markers of fatty acid desaturation: the GOCADAN study.
abstract: OBJECTIVE
  To determine if heart rate (HR) is associated with desaturation indexes as HR is associated with arrhythmia and sudden death.
  
  
  METHODS
  A community based cross-sectional study of 1214 Alaskan Inuit.
  
  
  METHODS
  Data of FA concentrations from plasma and red blood cell membranes from those ≥35 years of age (n = 819) were compared to basal HR at the time of examination. Multiple linear regression with backward stepwise selection was employed to analyze the effect of the desaturase indexes on HR, after adjustment for relevant covariates.
  
  
  RESULTS
  The Δ(5) desaturase index (Δ(5)-DI) measured in serum has recently been associated with a protective role for cardiovascular disease. This index measured here in plasma and red blood cells showed a negative correlation with HR. The plasma stearoyl-CoA-desaturase (SCD) index, previously determined to be related to cardiovascular disease (CVD) mortality, on the other hand, was positively associated with HR, while the Δ(6) desaturase index (Δ(6)-DI) had no significant effect on HR.
  
  
  CONCLUSIONS
  Endogenous FA desaturation is associated with HR and thereby, in the case of SCD, possibly with arrhythmia and sudden death, which would at least partially explain the previously observed association between cardiovascular mortality and desaturase activity.
authors.affiliation: GOCADAN Department, Norton Sound Health Corporation, Nome, AK 99762, USA. soebbesson@alaska.edu
authors.forename: Sven O E
authors.initials: SO
authors.lastname: Ebbesson
authors.forename: Juan C
authors.initials: JC
authors.lastname: Lopez-Alvarenga
authors.forename: Peter M
authors.initials: PM
authors.lastname: Okin
authors.forename: Richard B
authors.initials: RB
authors.lastname: Devereux
authors.forename: Maria Elizabeth
authors.initials: ME
authors.lastname: Tejero
authors.forename: William S
authors.initials: WS
authors.lastname: Harris
authors.forename: Lars O E
authors.initials: LO
authors.lastname: Ebbesson
authors.forename: Jean W
authors.initials: JW
authors.lastname: MacCluer
authors.forename: Charlotte
authors.initials: C
authors.lastname: Wenger
authors.forename: Sandra
authors.initials: S
authors.lastname: Laston
authors.forename: Richard R
authors.initials: RR
authors.lastname: Fabsitz
authors.forename: John
authors.initials: J
authors.lastname: Kennish
authors.forename: William J
authors.initials: WJ
authors.lastname: Howard
authors.forename: Barbara V
authors.initials: BV
authors.lastname: Howard
authors.forename: Jason
authors.initials: J
authors.lastname: Umans
authors.forename: Anthony G
authors.initials: AG
authors.lastname: Comuzzie
mesh_terms: D000328:Adult; D000413:Alaska; D015415:Biomarkers / Q000097:blood; D002318:Cardiovascular Diseases / Q000201:enzymology / Q000401:mortality; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D044943:Fatty Acid Desaturases / Q000097:blood*; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D004930:Inuit; D008297:Male
chemical_list: D015415:Biomarkers; D044943:Fatty Acid Desaturases