title: NDM-1-producing Klebsiella pneumoniae resistant to colistin in a French community patient without history of foreign travel.
abstract: A carbapenem-resistant Klebsiella pneumoniae strain, Kp5196, was responsible for an uncomplicated cystitis in a patient living at home and without history of foreign travel. This isolate produced the metallocarbapenemase NDM-1 and was resistant to all antibiotics except tetracyclines and colistin. The K. pneumoniae strain belonged to sequence type ST15, and bla(NDM-1) was carried by a nontypeable conjugative plasmid. Two months later, a similar ST15 isolate, Kp5241, was present in the patient but was additionally colistin resistant.
authors.affiliation: Université de Bordeaux, Microbiologie Fondamentale et Pathogénicité UMR 5234, Bordeaux, France. corinne.arpin@u-bordeaux2.fr
authors.forename: Corinne
authors.initials: C
authors.lastname: Arpin
authors.forename: Patrick
authors.initials: P
authors.lastname: Noury
authors.forename: Delphine
authors.initials: D
authors.lastname: Boraud
authors.forename: Laure
authors.initials: L
authors.lastname: Coulange
authors.forename: Alain
authors.initials: A
authors.lastname: Manetti
authors.forename: Catherine
authors.initials: C
authors.lastname: André
authors.forename: Fatima
authors.initials: F
authors.lastname: M'Zali
authors.forename: Claudine
authors.initials: C
authors.lastname: Quentin
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003091:Colistin / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics; D006801:Humans; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000201:enzymology*; D010957:Plasmids / Q000235:genetics; D013754:Tetracyclines / Q000494:pharmacology; D001618:beta-Lactamases / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D013754:Tetracyclines; D001618:beta-Lactamases; C552864:beta-lactamase NDM-1; D003091:Colistin