title: Diagnostic challenges in chronic antibody-mediated rejection.
abstract: Measurement of glomerular and peritubular capillaritis in kidney transplant biopsy samples identifies allograft dysfunction associated with alloantibodies. Sis et al. show that this technique has a higher sensitivity but lower specificity than the current diagnostic criteria using peritubular capillary C4d deposition, and that capillaritis is an independent predictor of progression to graft failure.
authors.affiliation: Department of Pathology, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, Boston, MA 02114, USA.
authors.forename: Evan A
authors.initials: EA
authors.lastname: Farkash
authors.forename: Robert B
authors.initials: RB
authors.lastname: Colvin
mesh_terms: D015704:CD4 Antigens / Q000276:immunology; D002908:Chronic Disease; D004730:Endothelium, Vascular / Q000276:immunology / Q000473:pathology; D006084:Graft Rejection / Q000175:diagnosis* / Q000276:immunology* / Q000473:pathology; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology*; D007684:Kidney Tubules / Q000276:immunology; D012680:Sensitivity and Specificity; D014184:Transplantation, Homologous
chemical_list: D015704:CD4 Antigens