title: [Primary leiomyosarcoma of the kidney: a clinicopathological study of 13 cases at a high-volume institution].
abstract: OBJECTIVE
  To analyze the clinical characteristics, treatment, and survival of adult patients with renal leiomyosarcoma treated at our institution during the past 13 years.
  
  
  METHODS
  A retrospective review was performed to collect the demographic distribution, clinical manifestation, treatment, and outcome data about 13 adult patients of renal leiomyosarcoma treated at our institution from January 1996 to January 2008. The clinical parameters were analyzed to determine the effects on survival by logistic regression.
  
  
  RESULTS
  Mean age at diagnosis was 45.7 years (range 20 to 71), and 61.5% (8/13) were female. Mean tumor diameter was (11.1 +/- 10.2) cm (range 3 to 34 cm), 53.9% (7/13) had direct invasion of renal capsule, and 23.1% (3/13) had lymphovascular invasion. The follow-up information of 11 cases was available, and duration of follow-up was an average of 39.2 (range 9-81) months. The overall survival (OS) rate at 1, 3, and 5 years was 81.8%, 54.5%, and 16.2% respectively. 8 (72.7%) patients developed metastasis, and 9 (81.8%) patients eventually died. The survival of the patients did not show correlations with age, pathologic grade, extrarenal component, lymphovascular invasion, complete resection or not and chemotherapy or not.
  
  
  CONCLUSIONS
  Primary renal leiomyosarcoma has a poor survival prognosis regardless of the underlying histological and clinical features.
authors.affiliation: Department of Urology, West China Hospital, Sichuan University, Chengdu 610041, China.
authors.forename: Zi-Bing
authors.initials: ZB
authors.lastname: Xiong
authors.forename: Ming
authors.initials: M
authors.lastname: Shi
authors.forename: Ashok
authors.initials: A
authors.lastname: Kunwar
authors.forename: Ni
authors.initials: N
authors.lastname: Chen
authors.forename: Peng
authors.initials: P
authors.lastname: Zhang
authors.forename: Hao
authors.initials: H
authors.lastname: Zeng
authors.forename: Xiang
authors.initials: X
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D002681:China / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007680:Kidney Neoplasms / Q000401:mortality / Q000473:pathology*; D007890:Leiomyosarcoma / Q000401:mortality / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D015996:Survival Rate; D055815:Young Adult