title: Percutaneous valve replacement in a young adult for radiation-induced aortic stenosis.
abstract: A 46-year-old woman known with relapsing Hodgkin's lymphoma diagnosed at age 5, treated with repeated cycles of radiotherapy and chemotherapy, presented with severe symptomatic radiation-induced aortic stenosis. She also had other late sequelae of radiotherapy including thyroid cancer, mediastinal fribrosis and left pulmonary fibrosis with severe restrictive lung disease and a newly diagnosed renal carcinoma. Due to the prohibitively high surgical risk and need for urgent treatment, she underwent successful transcatheter aortic valve replacement with transfemoral implantation of a 23 mm Edwards SAPIEN-XT prosthesis, which was performed without valvuloplasty of the noncalcified fibrotic valve. The final result was excellent with reduction of the transaortic gradient and no residual aortic regurgitation.
authors.affiliation: Interventional Cardiology Unit, San Raffaele Scientific Institute, 48 Via M.Buonarroti, Milan, Italy. info@emocolumbus.it
authors.forename: Azeem
authors.initials: A
authors.lastname: Latib
authors.forename: Matteo
authors.initials: M
authors.lastname: Montorfano
authors.forename: Filippo
authors.initials: F
authors.lastname: Figini
authors.forename: Francesco
authors.initials: F
authors.lastname: Maisano
authors.forename: Alaide
authors.initials: A
authors.lastname: Chieffo
authors.forename: Stefano
authors.initials: S
authors.lastname: Benussi
authors.forename: Raimondo
authors.initials: R
authors.lastname: Bellanca
authors.forename: Chiara
authors.initials: C
authors.lastname: Gerli
authors.forename: Pietro
authors.initials: P
authors.lastname: Spagnolo
authors.forename: Ottavio
authors.initials: O
authors.lastname: Alfieri
authors.forename: Antonio
authors.initials: A
authors.lastname: Colombo
mesh_terms: D001021:Aortic Valve / Q000528:radiation effects*; D001024:Aortic Valve Stenosis / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery*; D059248:Chemoradiotherapy; D005260:Female; D019918:Heart Valve Prosthesis Implantation; D006689:Hodgkin Disease / Q000628:therapy; D006801:Humans; D008875:Middle Aged; D011832:Radiation Injuries / Q000000981:diagnostic imaging / Q000209:etiology / Q000601:surgery*; D011878:Radiotherapy / Q000009:adverse effects*; D014057:Tomography, X-Ray Computed