title: Assessment of the alkaline phosphatase level in gingival crevicular fluid, as a biomarker to evaluate the effect of scaling and root planing on chronic periodontitis: An in vivo study.
abstract: BACKGROUND
  Clinical evaluation of gingivitis and/or periodontitis does not predict the progression or remission of the disease. Due to this diagnostic constraint, clinicians assume that the pathology has an increased risk of progression and plan treatments, despite the knowledge that all inflamed sites are not necessarily progressing. Extensive research has been carried out on gingival crevicular fluid (GCF) components that might serve as potential diagnostic markers for periodontitis. Among them alkaline phosphatase (ALP) levels in GCF has shown promise as a diagnostic marker.
  
  
  OBJECTIVE
  This study compares the levels of GCF alkaline phosphatase in patients with chronic periodontitis before and after scaling and root planing.
  
  
  METHODS
  This study is an in vivo longitudinal study conducted on twenty patients with localized periodontitis. The GCF was collected from the affected site prior to scaling and root planing and ALP level estimated. The probing depth and plaque index at the site were also measured for correlation. Patients were recalled after 7, 30, and 60 days for reassessment.
  
  
  RESULTS
  The GCF ALP values showed a sustained, statistically significant decrease after treatment. There was a positive correlation with probing depth but not with plaque index measured at each interval.
  
  
  CONCLUSIONS
  The assessment of level of periodontal disease and effect of mechanical plaque control on the progression and regression of the disease can be evaluated precisely by the corresponding GCF ALP levels. Thus, alkaline phosphatase level is not only a biomarker for the pathology but also an indicator of prognosis of periodontitis.
authors.affiliation: Department of Periodontics, Narayana Dental College, Chinthareddypalem, Nellore, Andhra Pradesh, India.
authors.forename: Jimly James
authors.initials: JJ
authors.lastname: Kunjappu
authors.forename: Vinod Babu
authors.initials: VB
authors.lastname: Mathew
authors.forename: Shashikanth
authors.initials: S
authors.lastname: Hegde
authors.forename: Rajesh
authors.initials: R
authors.lastname: Kashyap
authors.forename: Rajesh
authors.initials: R
authors.lastname: Hosadurga