title: RAMPs as drug targets.
abstract: The receptor activity-modifying protein (RAMP) family of membrane proteins regulates G protein-coupled receptor (GPCR) function in several ways. RAMPs can alter their pharmacology and signalling as well as the trafficking of these receptors to and from the cell surface. Accordingly, RAMPs may be exploited as drug targets, offering new opportunities for regulating the function of therapeutically relevant RAMP-interacting GPCRs. For example, several small molecule antagonists of RAMP1/ calcitonin receptor-like receptor complexes, which block the actions of the neuropeptide calcitonin gene-related peptide are in development for the treatment of migraine headache.
authors.affiliation: Department of Pharmacology, Monash University, Victoria, Australia.
authors.forename: Patrick M
authors.initials: PM
authors.lastname: Sexton
authors.forename: David R
authors.initials: DR
authors.lastname: Poyner
authors.forename: John
authors.initials: J
authors.lastname: Simms
authors.forename: Arthur
authors.initials: A
authors.lastname: Christopoulos
authors.forename: Debbie L
authors.initials: DL
authors.lastname: Hay
mesh_terms: D058261:Receptor Activity-Modifying Proteins / Q000187:drug effects*; D043562:Receptors, G-Protein-Coupled / Q000187:drug effects; D015398:Signal Transduction
chemical_list: D058261:Receptor Activity-Modifying Proteins; D043562:Receptors, G-Protein-Coupled