title: Ileal leiomyosarcoma and lymph node granuloma. Relevance of a rare association.
abstract: Leiomyosarcoma is rare in ileal location. We report the case of a 61 years old female patient presenting with ileal leiomyosarcoma occurring at 14 years after a uterine carcinoma treated by radiotherapy. The ileal tumor was treated by surgical resection. This tumor was peculiar by the macroscopic polypoid appearance and by expression of PDGFRA protein together with muscle differentiation proteins: smooth muscle actin, desmin and h-caldesmon. Lymph node necrotizing granuloma diagnosis on the surgical resection specimen lead to the diagnosis of tuberculosis and the patient was treated accordingly. At 3 years after the diagnosis, the patient was well, without recurrence or metastases. In conclusion, we report the case of a patient diagnosed with ileal leiomyosarcoma occurring 14 years after adjuvant radiotherapy for uterine carcinoma. Analysis of the intestinal resection specimen lead to the diagnosis of associated tuberculosis. Moreover, the leiomyosarcoma was peculiar by PDGFRA expression, feature which might be of clinical relevance since the treatment options in radioinduced tumors associated with other conditions are limited.
authors.affiliation: Service d'Anatomie Pathologique, Hopitaux Universitaires Paris Seine Saint-Denis, AP-HP, Bobigny, France.
authors.forename: Alina
authors.initials: A
authors.lastname: Badescu
authors.forename: Marick
authors.initials: M
authors.lastname: Lae
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Morin
authors.forename: Adriana
authors.initials: A
authors.lastname: Handra-Luca
mesh_terms: D005260:Female; D006099:Granuloma / Q000150:complications*; D006801:Humans; D007078:Ileal Neoplasms / Q000150:complications*; D007890:Leiomyosarcoma / Q000150:complications*; D008206:Lymphatic Diseases / Q000150:complications*; D008875:Middle Aged