title: Effects of amino acid combinations on the development of organotypic culture of the myocardium from young and old rats.
abstract: Effects of 20 L-amino acids in concentration of 0.05 ng/ml on the development of myocardium of young (3-month-old) and old (24-month-old) rats in organotypic tissue culture were investigated. Stimulation of cell proliferation in the myocardium of young animals appeared under the influence of asparagine, histidine, serine, lysine, arginine, glutamic acid, and isoleucine. In the myocardium of old rats, proliferative effects remained only for two amino acids, lysine and arginine. Combinations of one stimulating and one inactive amino acids effectively increase the stimulating effect in both young and old rats. Modulating properties of amino acids and their combinations provide the basis for the synthesis of peptides regulating regenerative processes in the myocardium, particularly during aging.
authors.affiliation: St. Petersburg Institute of Bioregulation and Gerontology, Northwestern Division of Russian Academy of Medical Sciences, Russia. ni_chalisova@mail.ru
authors.forename: N I
authors.initials: NI
authors.lastname: Chalisova
authors.forename: A V
authors.initials: AV
authors.lastname: Smirnoff
mesh_terms: D000367:Age Factors; D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D006321:Heart / Q000187:drug effects*; D009206:Myocardium / Q000166:cytology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000596:Amino Acids