title: Vulval and perianal intraepithelial neoplasia: response to chemoradiotherapy in a woman with idiopathic CD4 lymphocytopenia.
abstract: Treatment of multicentric or multifocal anogenital intraepithelial neoplasia is challenging, especially if the patient has immunodeficiency. We report the case of a woman with idiopathic CD4 lymphocytopenia and vulval and perianal intraepithelial neoplasia with early invasive disease, who responded well to radiotherapy combined with chemotherapy. Chemoradiotherapy is often used in the primary treatment of anal carcinomas, but has rarely been reported as a treatment for premalignant anogenital conditions.
authors.affiliation: Department of Dermatology, West Suffolk Hospital, Bury St Edmunds, Suffolk, UK. nevtomson@hotmail.com
authors.forename: N
authors.initials: N
authors.lastname: Tomson
authors.forename: J
authors.initials: J
authors.lastname: Sterling
authors.forename: R
authors.initials: R
authors.lastname: Miller
authors.forename: C
authors.initials: C
authors.lastname: Wilson
authors.forename: P
authors.initials: P
authors.lastname: Baldwin
mesh_terms: D001005:Anus Neoplasms / Q000473:pathology / Q000628:therapy*; D002278:Carcinoma in Situ / Q000473:pathology / Q000628:therapy*; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000628:therapy*; D059248:Chemoradiotherapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D018344:T-Lymphocytopenia, Idiopathic CD4-Positive / Q000150:complications*; D016896:Treatment Outcome; D014846:Vulvar Neoplasms / Q000473:pathology / Q000628:therapy*