title: Failure of noninvasive prediction of pulmonary hypertension in patients with idiopathic pulmonary fibrosis.
abstract: BACKGROUND
  Pulmonary hypertension (PH) in patients with advanced idiopathic pulmonary fibrosis (IPF) is a complication connected with unfavorable prognosis. Great efforts have been made in attempting to establish a reliable non-invasive method which would enable detection of this complication. In this context a formula using pulmonary function parameters was published with outstanding results.
  
  
  METHODS
  We tested the formula in 27 IPF patients who underwent a lung function examination, cardiac ultrasonography and catheterisation on the same day.
  
  
  RESULTS
  Pulmonary hypertension was detected by catheterisation in 17 patients (63%). In our group, contrary to the published data, the aforementioned formula was neither useful for detecting patients with a high probability of PH nor as a means of calculating the mean pulmonary artery pressure in individual patients (p = 0.502 and p = 0.833, respectively). Ultrasound examination reached borderline correlation with the values measured by catheterisation when we compare patients with relevant results (r = 0.531, p = 0.051). However, the examination gave no usable results in 13 patients (48%).
  
  
  CONCLUSIONS
  Our data suggests that no reliable, noninvasive method is currently available for detecting and confirming PH in IPF patients. We did not confirm the usefulness of the published formula. Further carefully organised studies will be necessary to verify or refute it.
authors.affiliation: Department of Pneumology, University Hospital and Charles University Faculty of Medicine, Hradec Kralove, Czech Republic. salajka@fnhk.cz
authors.forename: F
authors.initials: F
authors.lastname: Salajka
authors.forename: V
authors.initials: V
authors.lastname: Bartos
authors.forename: J
authors.initials: J
authors.lastname: Novosad
authors.forename: J
authors.initials: J
authors.lastname: St'ásek
authors.forename: J
authors.initials: J
authors.lastname: Bis
authors.forename: M
authors.initials: M
authors.lastname: Brtko
authors.forename: P
authors.initials: P
authors.lastname: Polanský
authors.forename: V
authors.initials: V
authors.lastname: Koblízek
authors.forename: V
authors.initials: V
authors.lastname: Sedlák
mesh_terms: D000368:Aged; D006328:Cardiac Catheterization; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D011658:Pulmonary Fibrosis / Q000150:complications / Q000503:physiopathology; D015203:Reproducibility of Results; D012129:Respiratory Function Tests; D012680:Sensitivity and Specificity; D014463:Ultrasonography