title: Low-fluence photodynamic treatment modifies functional properties of vascular cell wall.
abstract: We studied the effect of low-fluence photodynamic treatment with Photosence preparation on functional properties of macrophages and endothelium in vitro. It was shown that low-intensity photodynamic treatment did not affect viability of these cells. Exposure (0.25 J/cm(2)) of endothelial cells loaded with Photosence did not change the expression of adhesion molecules, but reduced adhesion of peripheral blood mononuclears to these cells. The same low-intensity exposure inhibited phagocytic activity of macrophages and reduced activity of matrix metalloproteinase-9 produced by them.
authors.affiliation: Institute of Biomedical Problems, Russian Academy of Medical Sciences, Moscow, Russia. olja_udartseva@rambler.ru
authors.forename: O O
authors.initials: OO
authors.lastname: Udartseva
authors.forename: E R
authors.initials: ER
authors.lastname: Andreeva
authors.forename: L B
authors.initials: LB
authors.lastname: Buravkova
authors.forename: A V
authors.initials: AV
authors.lastname: Knizhnik
authors.forename: I N
authors.initials: IN
authors.lastname: Vozovikov
mesh_terms: D002478:Cells, Cultured; D004730:Endothelium, Vascular / Q000187:drug effects*; D006801:Humans; D008264:Macrophages / Q000187:drug effects*; D010778:Photochemotherapy