title: Acid-labile δ-ketal-β-hydroxy esters by asymmetric hydrogenation of corresponding δ-ketal-β-keto esters in the presence of CaCO3.
abstract: A series of acid-labile, optically pure ε-substituted δ-ketal-β-hydroxy esters were obtained by a Ru-SunPhos catalyzed asymmetric hydrogenation of the corresponding ε-substituted δ-ketal-β-keto esters. CaCO(3) played a dual role in the hydrogenation reaction--removing the acid generated during the formation of the catalyst and maintaining the activity of the catalyst.
authors.affiliation: School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.
authors.forename: Weizheng
authors.initials: W
authors.lastname: Fan
authors.forename: Wanfang
authors.initials: W
authors.lastname: Li
authors.forename: Xin
authors.initials: X
authors.lastname: Ma
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Tao
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Li
authors.forename: Ying
authors.initials: Y
authors.lastname: Yao
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Xie
authors.forename: Zhaoguo
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D002119:Calcium Carbonate / Q000737:chemistry*; D002384:Catalysis; D056831:Coordination Complexes / Q000737:chemistry; D004952:Esters; D006865:Hydrogenation; D006880:Hydroxy Acids / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry
chemical_list: D056831:Coordination Complexes; D004952:Esters; D006880:Hydroxy Acids; D012428:Ruthenium; D002119:Calcium Carbonate