title: Medium to high throughput screening: microfabrication and chip-based technology.
abstract: Medium to high throughput screening for toxicity testing can provide a wealth of information with significant time and cost savings. New technologies, such as microfabrication, microfluidics and chip-based technology, combined with advanced cell culture and detection techniques, open up new opportunities in toxicity testing. In this chapter, fundamentals of microfabrication and microfluidics are discussed with a focus on the broad and novel applications on toxicity studies enabled by these technologies. Emphasis is placed on microscale cell and tissue culture models for medium and high throughput systemic toxicity studies in vitro.
authors.affiliation: William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio, USA.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Wen
authors.forename: Xudong
authors.initials: X
authors.lastname: Zhang
authors.forename: Shang-Tian
authors.initials: ST
authors.lastname: Yang
mesh_terms: D000818:Animals; D055664:Electrochemical Techniques; D057166:High-Throughput Screening Assays / Q000379:methods*; D006801:Humans; D046210:Microfluidic Analytical Techniques / Q000379:methods*; D055616:Microtechnology / Q000379:methods*; D018675:Toxicity Tests / Q000379:methods*