title: Synthesis of 1,8-naphthyridines and their application in the development of anionic fluorogenic chemosensors.
abstract: Two 1,8-naphthyridines were synthesized and found to be fluorescent in solution. These compounds were studied in the presence of Cu(+) and Cu(2+) ions and it was verified that the metal causes the quenching of their fluorescence emission, due to the formation of complexes between the naphthyridine and the metal. A displacement assay was carried out in a DMSO-water mixture with the addition of various anions to the solutions of the complexes, and it was observed that these systems have a high capacity to selectively detect cyanide.
authors.affiliation: Departamento de Química, Universidade Regional de Blumenau, FURB, Blumenau, SC, 89010-971, Brazil.
authors.forename: Celso R
authors.initials: CR
authors.lastname: Nicoleti
authors.forename: Diogo N
authors.initials: DN
authors.lastname: Garcia
authors.forename: Luiz E
authors.initials: LE
authors.lastname: da Silva
authors.forename: Iêda M
authors.initials: IM
authors.lastname: Begnini
authors.forename: Ricardo A
authors.initials: RA
authors.lastname: Rebelo
authors.forename: Antonio C
authors.initials: AC
authors.lastname: Joussef
authors.forename: Vanderlei G
authors.initials: VG
authors.lastname: Machado
mesh_terms: D002623:Chemistry Techniques, Analytical / Q000295:instrumentation*; D060326:Chemistry Techniques, Synthetic; D003300:Copper / Q000737:chemistry; D003486:Cyanides / Q000032:analysis / Q000737:chemistry; D004121:Dimethyl Sulfoxide / Q000737:chemistry; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry*; D009287:Naphthyridines / Q000138:chemical synthesis* / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D003486:Cyanides; D005456:Fluorescent Dyes; D009287:Naphthyridines; D014867:Water; D003300:Copper; D004121:Dimethyl Sulfoxide