title: 3' Cap-independent translation enhancers of positive-strand RNA plant viruses.
abstract: Positive-strand RNA plant viruses that are neither 5'-capped nor 3'-polyadenylated use nontraditional mechanisms to recruit ribosomes to the 5'-end of their viral genomes. One strategy employed by some of these viruses involves a type of RNA element, termed the 3' cap-independent translation enhancer (3'CITE), located in or near the 3'-untranslated region of viral RNA genomes. 3'CITEs function to mediate efficient translation of 5'-proximally encoded viral proteins and function by recruiting either translation initiation factors or the 60S ribosomal subunit to the viral RNA. Recent mechanistic and structural studies have revealed important new insights and details of how 3'CITEs are able to facilitate viral translation and allow these viruses to compete efficiently against cellular mRNAs for the host translational machinery.
authors.affiliation: Department of Biology, York University, Toronto, Ontario, Canada M3J 1P3.
authors.forename: Beth L
authors.initials: BL
authors.lastname: Nicholson
authors.forename: K Andrew
authors.initials: KA
authors.lastname: White
mesh_terms: D004742:Enhancer Elements, Genetic; D015967:Gene Expression Regulation, Viral; D010935:Plant Diseases / Q000235:genetics / Q000821:virology*; D010942:Plant Viruses / Q000235:genetics* / Q000378:metabolism; D014176:Protein Biosynthesis; D012315:RNA Caps / Q000235:genetics*; D012367:RNA, Viral / Q000235:genetics* / Q000378:metabolism
chemical_list: D012315:RNA Caps; D012367:RNA, Viral