title: Comparison of magnesium sulfate and mannitol in treatment of eclamptic women with posterior reversible encephalopathy syndrome.
abstract: OBJECTIVE
  To evaluate and compare the effectiveness of magnesium sulfate (MgSO(4)) and mannitol in the treatment of posterior reversible encephalopathy syndrome (PRES) in eclamptic women.
  
  
  METHODS
  This retrospective analysis includes 62 eclamptic women between 22 and 40 weeks of gestation who were diagnosed with PRES in a tertiary care center. To treat neurological symptoms, 34 women received magnesium sulfate (Group 1) and the remaining 28 received 20% mannitol (Group 2) at the discretion of treating physician.
  
  
  RESULTS
  Ten patients from both Group 1 (29%) and Group 2 (35.7%) were normotensive at admission. 59 of 62 patients presented with seizure. All patients underwent fluid attenuated inversion recovery (FLAIR) magnetic resonance imaging (MRI). Parietooccipital region and cerebellum were the most commonly affected areas. The duration of treatment was significantly shorter in Group 1 than Group 2 (p < 0.001). Neurological examinations and the recovery after treatment were significantly better in favor of MgSO(4) group (p = 0.039).
  
  
  CONCLUSIONS
  Mannitol is not superior to magnesium sulfate in achieving neurological recovery. Magnesium sulfate seems to be the agent of choice for treatment of PRES.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Uludag University, Nilufer, 16059 Bursa, Turkey. bilgecd@uludag.edu.tr
authors.forename: Bilge Cetinkaya
authors.initials: BC
authors.lastname: Demir
authors.forename: Kemal
authors.initials: K
authors.lastname: Ozerkan
authors.forename: Sevda Erer
authors.initials: SE
authors.lastname: Ozbek
authors.forename: Nalan
authors.initials: N
authors.lastname: Yıldırım Eryılmaz
authors.forename: Gokhan
authors.initials: G
authors.lastname: Ocakoglu
mesh_terms: D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use*; D004461:Eclampsia / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008278:Magnesium Sulfate / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D008353:Mannitol / Q000627:therapeutic use*; D054038:Posterior Leukoencephalopathy Syndrome / Q000188:drug therapy*; D011247:Pregnancy; D012189:Retrospective Studies; D012640:Seizures / Q000188:drug therapy; D055815:Young Adult
chemical_list: D000927:Anticonvulsants; D008353:Mannitol; D008278:Magnesium Sulfate