title: Warfarin-induced leukocytoclastic vasculitis: a case report and review of literature.
abstract: Warfarin is widely prescribed for patients with atrial fibrillation. In addition to unexpected bleeding, allergic skin reaction is one of its uncommon adverse effects. We herein report an 89-year-old man who, after taking warfarin for 4 years, suffered extensive skin eruptions. The skin biopsy disclosed leukocytoclastic vasculitis. The causal relationship between skin lesions and warfarin was confirmed after re-challenge of warfarin. A literature review revealed only 13 such cases reported from 1980 to 2011. Clinicians should be aware of this potential adverse effect of warfarin.
authors.affiliation: Division of Cardiology, Taipei Veterans General Hospital, Taiwan.
authors.forename: Chien-Yi
authors.initials: CY
authors.lastname: Hsu
authors.forename: Wei-Sheng
authors.initials: WS
authors.lastname: Chen
authors.forename: Shih-Hsien
authors.initials: SH
authors.lastname: Sung
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000009:adverse effects* / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000150:complications; D003327:Coronary Disease / Q000150:complications; D003875:Drug Eruptions / Q000209:etiology*; D006333:Heart Failure / Q000150:complications; D006801:Humans; D006973:Hypertension / Q000150:complications; D008297:Male; D011507:Proteinuria / Q000139:chemically induced; D013624:Taiwan; D019851:Thrombophilia / Q000188:drug therapy / Q000209:etiology; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000139:chemically induced* / Q000175:diagnosis; D014859:Warfarin / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000925:Anticoagulants; D014859:Warfarin