title: DNA structure, nucleosome placement and chromatin remodelling: a perspective.
abstract: A major question in chromatin biology is to what extent the sequence of DNA directly determines the genetic and chromatin organization of a eukaryotic genome? We consider two aspects to this question: the DNA sequence-specified positioning of nucleosomes and the determination of NDRs (nucleosome-depleted regions) or barriers. We argue that, in budding yeast, while DNA sequence-specified nucleosome positioning may contribute to positions flanking the regions lacking nucleosomes, DNA thermodynamic stability is a major component determinant of the genetic organization of this organism.
authors.affiliation: MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, U.K. aat@mrc-lmb.cam.ac.uk
authors.forename: Andrew A
authors.initials: AA
authors.lastname: Travers
authors.forename: Cédric
authors.initials: C
authors.lastname: Vaillant
authors.forename: Alain
authors.initials: A
authors.lastname: Arneodo
authors.forename: Georgi
authors.initials: G
authors.lastname: Muskhelishvili
mesh_terms: D042002:Chromatin Assembly and Disassembly; D045584:Chromosome Positioning; D004247:DNA / Q000737:chemistry*; D005796:Genes / Q000235:genetics; D009707:Nucleosomes / Q000378:metabolism*
chemical_list: D009707:Nucleosomes; D004247:DNA