title: Impact of intensive upper limb rehabilitation on quality of life: a randomized trial in children with unilateral cerebral palsy.
abstract: OBJECTIVE
  The aim of this study was to determine whether constraint-induced movement therapy is more effective than bimanual training in improving the quality of life of children with unilateral cerebral palsy (CP).
  
  
  METHODS
  Sixty-three children (mean age 10y 2mo [SD 2y 6mo]; 33 males, 30 females) with CP of the spastic motor type (n=59) or with spasticity and dystonia (n=4) were randomly allocated to two groups. The children were assessed as Manual Ability Classification System level I (n=16), II (n=46), or III (n=1). Each group received 6 hours of daily intervention (either constraint-induced movement therapy [CIMT] or bimanual training [BIM]) for 10 days over a 2-week period (total intervention time 60h). Children aged 9 years and older completed the Cerebral Palsy Quality of Life Questionnaire for Children (CPQOL-Child) and those aged 8 years and older completed the KIDSCREEN-52. All parents completed proxy versions of each measure. Assessments were made at baseline and at 3, 26, and 52 weeks after the end of the intervention.
  
  
  RESULTS
  Thirty-five children completed the CPQOL-Child and 41 completed the KIDSCREEN-52. No changes in social or emotional well-being were reported by children in either group. Children and parents from both groups reported a significant improvement in their or their child's feelings about functioning as well as participation and physical health on the CPQOL-Child. The parents of children receiving CIMT reported positive and sustained changes in their child's social well-being (CPQOL-Child). The CIMT group showed significant improvements in physical well-being, psychological well-being, and moods and emotions (KIDSCREEN-52) at 3 weeks post intervention, which were maintained over the study period.
  
  
  CONCLUSIONS
  Intensive goal-directed upper limb training programmes using either CIMT or BIM achieved domain-specific changes in quality of life relating to feelings about functioning and participation and physical health. A condition-specific quality of life compared with a generic measure may be better able to detect changes in quality of life in children with unilateral CP.
authors.affiliation: Queensland Cerebral Palsy and Rehabilitation Research Centre, The University of Queensland, Brisbane, QLD, Australia. leanne.sakzewski@uqconnect.edu.au
authors.forename: Leanne
authors.initials: L
authors.lastname: Sakzewski
authors.forename: Stacey
authors.initials: S
authors.lastname: Carlon
authors.forename: Nora
authors.initials: N
authors.lastname: Shields
authors.forename: Jenny
authors.initials: J
authors.lastname: Ziviani
authors.forename: Robert S
authors.initials: RS
authors.lastname: Ware
authors.forename: Roslyn N
authors.initials: RN
authors.lastname: Boyd
mesh_terms: D000203:Activities of Daily Living / Q000145:classification; D000293:Adolescent; D002165:Camping; D016022:Case-Control Studies; D002547:Cerebral Palsy / Q000523:psychology / Q000534:rehabilitation*; D002648:Child; D003631:Day Care, Medical; D004185:Disability Evaluation; D005260:Female; D005500:Follow-Up Studies; D007839:Functional Laterality; D006429:Hemiplegia / Q000534:rehabilitation*; D006801:Humans; D008297:Male; D009788:Occupational Therapy; D026741:Physical Therapy Modalities; D011788:Quality of Life / Q000523:psychology; D011793:Queensland; D012149:Restraint, Physical; D016037:Single-Blind Method