title: The perils of pharmacological treatment for obesity: a case of sibutramine-associated cardiomyopathy and malignant arrhythmias.
abstract: A 58-year-old woman presented with severe left ventricular dysfunction and malignant arrhythmias after taking combination drug treatment for weight loss. The combination treatment included sibutramine, liothyronine, hydrochlorothiazide diuretic, metformin and fucus. The effect of these drugs individually and in combination is discussed, with particular reference to it being a malignant combination. The patient showed reversability of the left ventricular dysfunction and negative ventricular stimulation studies after cessation of the drug concoction.
authors.affiliation: Milpark Hospital, Johannesburg, South Africa. cscham@global.co.za
authors.forename: C L
authors.initials: CL
authors.lastname: Schamroth
mesh_terms: D000638:Amiodarone / Q000627:therapeutic use; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D001067:Appetite Depressants / Q000008:administration & dosage / Q000009:adverse effects*; D002312:Cardiomyopathy, Hypertrophic / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D003503:Cyclobutanes / Q000008:administration & dosage / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D004562:Electrocardiography; D004636:Emergency Service, Hospital; D005260:Female; D044645:Fucus; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000188:drug therapy*; D018487:Ventricular Dysfunction, Left / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy*; D018879:Ventricular Premature Complexes / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy
chemical_list: D000889:Anti-Arrhythmia Agents; D001067:Appetite Depressants; D003503:Cyclobutanes; D000638:Amiodarone; C058254:sibutramine