title: Neural connectivity of the pedunculopontine nucleus in relation to walking ability in chronic patients with intracerebral hemorrhage.
abstract: OBJECTIVE
  As the mesencephalic locomotor center, the pedunculopontine nucleus (PPN) is known to be involved in control of locomotor function. We investigated neural connectivity of the PPN in relation to walking ability in chronic patients with spontaneous intracerebral hemorrhage.
  
  
  METHODS
  Forty-three consecutive chronic patients with subcortical hemorrhage and 20 healthy control subjects were recruited. A seed region of interest was manually drawn on the PPN and connectivity of the PPN was measured.
  
  
  RESULTS
  In the affected hemisphere, connectivity with the ipsilesional cerebellar locomotor center and connectivity with the contralesional pontine locomotor center were decreased in patients who could not walk, compared with patients who could walk and normal controls (p < 0.05).
  
  
  CONCLUSIONS
  Connectivity between the PPN and ipsi-lesional cerebellum locomotor center and contralesional pontine locomotor center in the affected hemisphere appears to be related to walking ability.
authors.affiliation: Department of Physical Medicine and Rehabilitation, College of Medicine, Yeungnam University, Taegu, Republic of Korea.
authors.forename: Sang Seok
authors.initials: SS
authors.lastname: Yeo
authors.forename: Dong Gyu
authors.initials: DG
authors.lastname: Lee
authors.forename: Byung Yeon
authors.initials: BY
authors.lastname: Choi
authors.forename: Chul Hoon
authors.initials: CH
authors.lastname: Chang
authors.forename: Young Jin
authors.initials: YJ
authors.lastname: Jung
authors.forename: Seong Ho
authors.initials: SH
authors.lastname: Kim
authors.forename: Min Cheol
authors.initials: MC
authors.lastname: Chang
authors.forename: Sung Ho
authors.initials: SH
authors.lastname: Jang
mesh_terms: D000328:Adult; D000368:Aged; D001931:Brain Mapping; D002543:Cerebral Hemorrhage / Q000473:pathology* / Q000503:physiopathology*; D002908:Chronic Disease; D056324:Diffusion Tensor Imaging; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000473:pathology*; D045042:Pedunculopontine Tegmental Nucleus / Q000473:pathology*; D012720:Severity of Illness Index; D016138:Walking / Q000502:physiology*; D055815:Young Adult