title: Patterns of autobiographical memory in bipolar disorder examined by psychometric and functional neuroimaging methods.
abstract: This is the first study to combine psychometric and functional neuroimaging methods to study altered patterns of autobiographical memory in bipolar disorder (BD). All participants were interviewed with an expanded version of the Bielefelder Autobiographical Memory Inventory (Bielefelder Autobiographisches Gedächtnis Inventar 2004;Lisse: Swets and Zeitlinger). We then acquired functional magnetic resonance imaging data during a task of individually designed autobiographical recall. Compared with healthy controls, BD patients reported a stronger emotionality of autobiographical memories and more frequent recollections of autobiographical events during their everyday life. Furthermore, they failed to deactivate areas in the cuneus and lingual gyrus and showed decreased activation in the inferior frontal and precentral areas compared with the control group. More frequent intrusions from a person's past, which had a neural correlate in the lack of deactivation in some default mode network areas in BD patients, may contribute to manic or depressive symptoms.
authors.affiliation: Laboratory of Neuroscience, Department of Psychiatry, Psychosomatic Medicine and Psychotherapy, Goethe-University, Frankfurt/Main, Germany. Viola.Oertel@kgu.de
authors.forename: Viola
authors.initials: V
authors.lastname: Oertel-Knöchel
authors.forename: Britta
authors.initials: B
authors.lastname: Reinke
authors.forename: Alexandra
authors.initials: A
authors.lastname: Hornung
authors.forename: Christian
authors.initials: C
authors.lastname: Knöchel
authors.forename: Silke
authors.initials: S
authors.lastname: Matura
authors.forename: Monika
authors.initials: M
authors.lastname: Knopf
authors.forename: David
authors.initials: D
authors.lastname: Prvulovic
authors.forename: Laurence
authors.initials: L
authors.lastname: O'Dwyer
authors.forename: Michael
authors.initials: M
authors.lastname: Lindner
authors.forename: Alexandra
authors.initials: A
authors.lastname: Rau
authors.forename: Harald
authors.initials: H
authors.lastname: Hampel
authors.forename: Corinna
authors.initials: C
authors.lastname: Haenschel
authors.forename: David E J
authors.initials: DE
authors.lastname: Linden
mesh_terms: D000328:Adult; D001714:Bipolar Disorder / Q000503:physiopathology* / Q000523:psychology; D004644:Emotions / Q000502:physiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D061212:Memory, Episodic; D011939:Mental Recall / Q000502:physiology; D008875:Middle Aged; D009415:Nerve Net / Q000503:physiopathology*; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D011594:Psychometrics / Q000379:methods