title: [Effects of multi-nutrients supplementation on the nutritional status and antioxidant capability of healthy adults].
abstract: OBJECTIVE
  To determine whether daily multivitamins/minerals supplement can improve nutrient status, plasma, antioxidant enzymes activity and total antioxidant capacity in healthy adults.
  
  
  METHODS
  One hundred and fifty-one healthy adults living in a normal lifestyle with a mean age of 28 (20 - 50) years were recruited from Guangzhou. The subjects were divided into the supplement group and the control ineral supplements.
  
  
  METHODS
  One hundred and fifty-one healthy adults living in a normal lifestyle with a mean age of 28 (20 - 50) years were recruited from Guangzhou. The subjects were divided into the supplement group and the control group carefully matched with age and gender. Supplement pellets (consisted of multivitamins/minerals, including VitA, VitC, VitE,Ca, Zn, Fe, Se, etc.) and placebo pellets (consisted of only dextrin with the same color, shape and size as the supplement pellets) were administrated in a double-blinded manner for 8 week. The nutrients intake data of the research subjects were collected daily by a 24-hour dietary recall method. Blood samples were collected at the beginning and the end of the intervention period for determining the nutritional status, the activities of antioxidant enzymes and the products of oxidative damage.
  
  
  RESULTS
  The dietary intake of nutrients was insufficient in these subjects. The levels of plasma VitC, alpha-tocopherol, beta-carotene, Zn, Fe and Se in the supplement group were increased in comparison with the control group by 46%, 28%, 116%, 7%, 30% and 28% respectively (P < 0.05), indicating that the nutritional status regarding antioxidant nutrients had largely been improved. But levels of plasma gamma-tocopherol were decreased by 25% in comparison with the control group (P < 0.05). The activities of GPX, CAT and T-AOC were increased in comparison with the control group and before the supplementation (P < 0.05), while the activities of SOD and the level of 8-isoprostanes remained steady.
  
  
  CONCLUSIONS
  Supplementation of multiple micronutrients could effectively increase the levels of plasma VitC, alpha-tocopherol, beta-carotene, Zn, Fe and Se and the activities of GPX, CAT and T-AOC.
authors.affiliation: College of Food Science, South China Agricultural University, Guangzhou 510642, China. lmy1982@scau.edu.cn
authors.forename: Meiying
authors.initials: M
authors.lastname: Li
authors.forename: Yanfang
authors.initials: Y
authors.lastname: Li
authors.forename: Zhaoyan
authors.initials: Z
authors.lastname: Wu
authors.forename: Wenjing
authors.initials: W
authors.lastname: Huang
authors.forename: Zhuoqin
authors.initials: Z
authors.lastname: Jiang
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000097:blood; D002374:Catalase / Q000097:blood; D019587:Dietary Supplements; D004311:Double-Blind Method; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D009752:Nutritional Status; D012643:Selenium / Q000008:administration & dosage; D014131:Trace Elements / Q000008:administration & dosage*; D014810:Vitamin E / Q000008:administration & dosage; D014815:Vitamins / Q000008:administration & dosage*; D055815:Young Adult; D015032:Zinc / Q000008:administration & dosage
chemical_list: D000975:Antioxidants; D014131:Trace Elements; D014815:Vitamins; D014810:Vitamin E; D002374:Catalase; D005979:Glutathione Peroxidase; D012643:Selenium; D015032:Zinc; D001205:Ascorbic Acid