title: [Screening and confirmation of psychotropic drugs in blood and urine by HPLC-LTQ Orbitrap MS].
abstract: OBJECTIVE
  To establish a screening and confirmation method for psychotropic drugs and their metabolites in human blood and urine by HPLC-LTQ Orbitrap MS.
  
  
  METHODS
  The samples were pretreated with Sirocco protein precipitation plate, and then analyzed by HPLC-LTQ Orbitrap MS. The method was validated in terms of the limit of detection (LOD). An accurate mass database was created for psychotropic drugs screening.
  
  
  RESULTS
  The LOD for most of 56 determined compounds was < or = 0.1 ng/mL. The accurate mass database included the accurate mass information of 61 psychotropic drugs.
  
  
  CONCLUSIONS
  The method is accurate, rapid, sensitive and the database is suitable for psychotropic drugs screening and confirmation.
authors.affiliation: Department of Forensic Medicine, Shanghai Medical College, Fudan University, Shanghai 200032, China. 09211010055@fudan.edu.cn
authors.forename: Xiao-Wen
authors.initials: XW
authors.lastname: Li
authors.forename: Bao-Hua
authors.initials: BH
authors.lastname: Shen
authors.forename: Zheng
authors.initials: Z
authors.lastname: Jiang
authors.forename: Xian-Yi
authors.initials: XY
authors.lastname: Zhuo
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D053593:Forensic Toxicology; D006801:Humans; D013058:Mass Spectrometry / Q000379:methods*; D015394:Molecular Structure; D008970:Molecular Weight; D011619:Psychotropic Drugs / Q000097:blood* / Q000737:chemistry / Q000506:poisoning / Q000652:urine*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D015813:Substance Abuse Detection / Q000379:methods
chemical_list: D011619:Psychotropic Drugs