title: The rs10830963 variant of melatonin receptor MTNR1B is associated with increased risk for gestational diabetes mellitus in a Greek population.
abstract: OBJECTIVE
  To investigate the association between Gestational Diabetes Mellitus (GDM) and the variants rs10830963 and rs1387153 in the MTNR1B locus in a sample of the Greek population.
  
  
  METHODS
  One hundred seventy-five unrelated pregnant Greek women (77 with GDM and 98 non-diabetic control subjects) were enrolled and the SNaPshot method was employed in order to investigate the association between GDM and the variants rs10830963 and rs1387153 in the MTNR1B locus. Pregnant women were screened for GDM at the 26th week with the 75 g glucose oral glucose tolerance test according to the American Diabetes Association criteria.
  
  
  RESULTS
  The GG genotype and the G-allele of the rs10830963 (C/G) variant was found to be positively associated with a significantly increased risk for GDM (p = 0.047 and p = 0.012, respectively). No differences in fasting glucose and insulin levels were found between GDM patients with and without the studied variants. The MTNR1B locus (rs10830963 C/G) seems to predispose for GDM in Greek pregnant women.
  
  
  CONCLUSIONS
  Our study confirms the association of GDM with the rs10830963 (C/G) variant in a sample of the Greek population. Population based whole genome screening studies and larger studies with detailed phenotypic data in patients with GDM are needed to address the clinical significance of this finding.
authors.affiliation: Endocrine Unit, 2nd Department of Obstetrics and Gynaecology, Aretaieion University Hospital, Athens Medical School, Greece.
authors.forename: Margarita
authors.initials: M
authors.lastname: Vlassi
authors.forename: Maria
authors.initials: M
authors.lastname: Gazouli
authors.forename: George
authors.initials: G
authors.lastname: Paltoglou
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Christopoulos
authors.forename: Lina
authors.initials: L
authors.lastname: Florentin
authors.forename: Georgia
authors.initials: G
authors.lastname: Kassi
authors.forename: George
authors.initials: G
authors.lastname: Mastorakos
mesh_terms: D000328:Adult; D016640:Diabetes, Gestational / Q000235:genetics* / Q000378:metabolism*; D005260:Female; D005786:Gene Expression Regulation / Q000502:physiology*; D014644:Genetic Variation; D005838:Genotype; D006115:Greece / Q000453:epidemiology; D006801:Humans; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D044122:Receptor, Melatonin, MT1 / Q000235:genetics / Q000378:metabolism*; D044123:Receptor, Melatonin, MT2
chemical_list: C573871:MTNR1B protein, human; D044122:Receptor, Melatonin, MT1; D044123:Receptor, Melatonin, MT2