title: Contribution of cytokines to pathology and protection in virus infection.
abstract: Acute and chronic viral infections greatly contribute to global health burden. While concerted action of multiple elements of the immune system help the host cope with most viruses, some infections lead to host damage or death. Cytokines are central drivers and controllers of both immune-mediated virus elimination and of immunopathology. Here, we review recent progress in understanding the protective and damaging roles in viral infections of cytokines and chemokines associated with innate, regulatory, and Th1, Th2 and Th17 responses.
authors.affiliation: Division of Immunoregulation, The MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK.
authors.forename: Andreas
authors.initials: A
authors.lastname: Wack
authors.forename: Peter
authors.initials: P
authors.lastname: Openshaw
authors.forename: Anne
authors.initials: A
authors.lastname: O'Garra
mesh_terms: D000818:Animals; D018925:Chemokines / Q000276:immunology*; D016207:Cytokines / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D014777:Virus Diseases / Q000276:immunology* / Q000473:pathology / Q000517:prevention & control; D014780:Viruses / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity*
chemical_list: D018925:Chemokines; D016207:Cytokines