title: Changes in cyclooxygenase-2 immunoreactivity in the hippocampus in a model of streptozotocin-induced type 1 diabetic rats.
abstract: In this study, we investigated diabetic stage dependent cyclooxygenase-2 (COX-2) immunoreactivity in the dentate gyrus in streptozotocin (STZ)-induced type 1 diabetic rats. The animals were sacrificed at 2, 3 and 4 weeks after STZ treatment. Blood glucose levels were increased after STZ treatment. COX-2 immunoreactivity in dentate gyrus was significantly increased in these regions 3 weeks after STZ treatment and restored to its basal level to 4 weeks after STZ treatment. In contrast, COX-2 immunoreactivity was not changed in CA3 region in all groups. These results suggest that STZ-induced type 1 diabetes transiently, but not permanently, decreased synaptic transmission and plasticity 3 weeks after STZ treatment in the dentate gyrus.
authors.affiliation: Department of Anatomy and Cell Biology, College of Veterinary Medicine, and Research Institute for Veterinary Science, Seoul National University, Seoul 151-742, South Korea.
authors.forename: Sung Min
authors.initials: SM
authors.lastname: Nam
authors.forename: Sun Shin
authors.initials: SS
authors.lastname: Yi
authors.forename: Dae Young
authors.initials: DY
authors.lastname: Yoo
authors.forename: Woosuk
authors.initials: W
authors.lastname: Kim
authors.forename: Jung Hoon
authors.initials: JH
authors.lastname: Choi
authors.forename: In Koo
authors.initials: IK
authors.lastname: Hwang
authors.forename: Je Kyung
authors.initials: JK
authors.lastname: Seong
authors.forename: Yeo Sung
authors.initials: YS
authors.lastname: Yoon
mesh_terms: D000818:Animals; D001786:Blood Glucose; D051546:Cyclooxygenase 2 / Q000235:genetics / Q000378:metabolism*; D018891:Dentate Gyrus / Q000201:enzymology*; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology*; D009473:Neuronal Plasticity / Q000187:drug effects; D051381:Rats; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D051546:Cyclooxygenase 2