title: Preventive effect of embelin from embelia ribes on lipid metabolism and oxidative stress in high-fat diet-induced obesity in rats.
abstract: A high-fat diet (HFD) results in hyperlipidemia and an increase in oxidative stress. The purpose of this study was to investigate the preventive effect of embelin against hyperlipidemia and oxidative stress in HFD-induced obesity in rats. Male Wistar rats aged 12 weeks (150-200 g) were fed with an HFD for a period of 28 days to induce experimental obesity. HFD-induced obese rats were treated with embelin (50 mg/kg) or orlistat (10 mg/kg) for 21 days. A range of parameters were tested including body weight gain, body mass index (BMI), blood pressure, visceral fat pad weights, serum levels of glucose, insulin, leptin, apolipoprotein B (ApoB), total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), hepatic thiobarbituric acid-reactive substances (TBARS), superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH). Twenty-one days of embelin (50 mg/kg) treatment produced effects similar to orlistat in reducing body weight gain, blood pressure, visceral fat pad weight, serum lipid levels, as well as coronary artery risk and atherogenic indices of HFD-fed rats. Embelin treatment also lowered the serum levels of glucose by 24.77 %, insulin by 35.03 %, and leptin by 43.39 %. Furthermore, embelin treatment significantly (p < 0.01) decreased the hepatic TBARS levels, while increasing the SOD, CAT, and GSH levels in obese rats. The present study indicated the preventive effect of embelin in HFD-induced obesity and its related complications. Embelin could be valuable in the development of new drug therapies to prevent obesity, hyperlipidemia, and oxidative stress.
authors.affiliation: Department of Pharmacology, Faculty of Pharmacy, Jamia Hamdard (Hamdard University), New Delhi, India.
authors.forename: Hemantkumar Somabhai
authors.initials: HS
authors.lastname: Chaudhari
authors.forename: Uma
authors.initials: U
authors.lastname: Bhandari
authors.forename: Geetika
authors.initials: G
authors.lastname: Khanna
mesh_terms: D000818:Animals; D019440:Anti-Obesity Agents / Q000627:therapeutic use*; D000975:Antioxidants / Q000627:therapeutic use; D016227:Benzoquinones / Q000627:therapeutic use*; D059305:Diet, High-Fat; D031645:Embelia / Q000737:chemistry; D005638:Fruit / Q000737:chemistry; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications / Q000188:drug therapy; D007783:Lactones / Q000627:therapeutic use; D008049:Lipase / Q000037:antagonists & inhibitors; D050356:Lipid Metabolism / Q000187:drug effects*; D008297:Male; D009765:Obesity / Q000150:complications / Q000378:metabolism* / Q000517:prevention & control*; D000077403:Orlistat; D018384:Oxidative Stress / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar
chemical_list: D019440:Anti-Obesity Agents; D000975:Antioxidants; D016227:Benzoquinones; D007783:Lactones; D010936:Plant Extracts; D000077403:Orlistat; D008049:Lipase; C010945:embelin