title: Defining and detecting malaria epidemics in south-east Iran.
abstract: BACKGROUND
  A lack of consensus on how to define malaria epidemics has impeded the evaluation of early detection systems. This study aimed to develop local definitions of malaria epidemics in a known malarious area of Iran, and to use that definition to evaluate the validity of several epidemic alert thresholds.
  
  
  METHODS
  Epidemic definition variables generated from surveillance data were plotted against weekly malaria counts to assess which most accurately labelled aberrations. Various alert thresholds were then generated from weekly counts or log counts. Finally, the best epidemic definition was used to calculate and compare sensitivities, specificities, detection delays, and areas under ROC curves of the alert thresholds.
  
  
  RESULTS
  The best epidemic definition used a minimum duration of four weeks and week-specific and overall smoothed geometric means plus 1.0 standard deviation. It defined 13 epidemics. A modified C-SUM alert of untransformed weekly counts using a threshold of mean+0.25 SD had the highest combined sensitivity and specificity. Untransformed C-SUM alerts also had the highest area under the ROC curve.
  
  
  CONCLUSIONS
  Defining local malaria epidemics using objective criteria facilitated the evaluation of alert thresholds. This approach needs further study to refine epidemic definitions and prospectively evaluate epidemic alerts.
authors.affiliation: Diocese of Hyderabad, Ashraf Goth, Rattanabad, PO Box 21, Mirpur Khas 69000, Sindh, Pakistan.
authors.forename: William R
authors.initials: WR
authors.lastname: McKelvie
authors.forename: Ali Akbar
authors.initials: AA
authors.lastname: Haghdoost
authors.forename: Ahmad
authors.initials: A
authors.lastname: Raeisi
mesh_terms: D058872:Epidemics; D004812:Epidemiologic Methods; D006801:Humans; D015994:Incidence; D007492:Iran / Q000453:epidemiology; D008288:Malaria / Q000453:epidemiology*; D012372:ROC Curve; D012680:Sensitivity and Specificity