title: Inflammation augments the development of experimental glomerulonephritis by accelerating proteinuria and enhancing mortality.
abstract: Proteinuria represents a parameter for a damaged filtration capacity of the kidney. We investigated how inflammation influences the development of experimental, immune complex-mediated glomerulonephritis by monitoring proteinuria. Mice pre-treated with LPS or TNF, one day before induction of glomerulonephritis, excreted high levels of protein in the urine immediately after the induction of glomerulonephritis, in contrast to non-treated mice where proteinuria increased steadily after day 3. Protein levels in the urine of pre-treated mice remained elevated over the 15-day observation time. The severity of proteinuria at later times correlated with the degree of tissue pathology and mortality in individual mice. Pre-treatment with inflammatory agents accelerated the development of proteinuria and induced more severe kidney damage.
authors.affiliation: Department of Immunology, University of Regensburg, F.-J.-Strauss-Allee 11, Regensburg, Germany.
authors.forename: Eva
authors.initials: E
authors.lastname: Pfeifer
authors.forename: Johannes
authors.initials: J
authors.lastname: Polz
authors.forename: Daniela N
authors.initials: DN
authors.lastname: Männel
authors.forename: Sven
authors.initials: S
authors.lastname: Mostböck
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000906:Antibodies / Q000009:adverse effects; D003404:Creatinine / Q000097:blood / Q000652:urine; D050533:Glomerular Basement Membrane / Q000276:immunology; D005921:Glomerulonephritis / Q000139:chemically induced / Q000276:immunology* / Q000378:metabolism; D007668:Kidney / Q000473:pathology*; D008070:Lipopolysaccharides / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D011507:Proteinuria / Q000652:urine*; D011817:Rabbits; D011994:Recombinant Proteins; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology* / Q000378:metabolism
chemical_list: D000906:Antibodies; D008070:Lipopolysaccharides; D011994:Recombinant Proteins; C439524:TNF protein, human; D014409:Tumor Necrosis Factor-alpha; D003404:Creatinine