title: Novel TEMPO-PEG-RGDs conjugates remediate tissue damage induced by acute limb ischemia/reperfusion.
abstract: We have recently developed new Tempo-PEG-RGDs conjugates and have quantitatively examined their antithrombotic and antioxidant capabilities. These compounds were therapeutically beneficial when characterized in both in vitro platelet aggregation assays and a rat model of arterial thrombosis. Moreover, these compounds demonstrated significant protection from organ damage in a rat model of ischemia/reperfusion. Our data indicate that Tempo-PEG-RGDs represent a new class of adjuvants with therapeutic efficacy in acute and transient ischemic damage.
authors.affiliation: Department of Surgery, Second Hospital of HeBei Medical University, HeBei Medical University, Shijiazhuang 050000, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Bi
authors.forename: Xiaoxu
authors.initials: X
authors.lastname: Li
authors.forename: Yue
authors.initials: Y
authors.lastname: Bi
authors.forename: Ping
authors.initials: P
authors.lastname: Xue
authors.forename: Yanrong
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xiang
authors.initials: X
authors.lastname: Gao
authors.forename: Zhibo
authors.initials: Z
authors.lastname: Wang
authors.forename: Meng
authors.initials: M
authors.lastname: Li
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Itagaki
authors.forename: Lanrong
authors.initials: L
authors.lastname: Bi
mesh_terms: D000818:Animals; D003497:Cyclic N-Oxides / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000138:chemical synthesis* / Q000494:pharmacology; D006614:Hindlimb / Q000098:blood supply; D006651:Histocytochemistry; D008315:Malondialdehyde / Q000097:blood; D018482:Muscle, Skeletal / Q000503:physiopathology; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000494:pharmacology; D018384:Oxidative Stress / Q000502:physiology*; D010974:Platelet Aggregation / Q000502:physiology; D011092:Polyethylene Glycols / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D015427:Reperfusion Injury / Q000097:blood / Q000188:drug therapy*; D013482:Superoxide Dismutase / Q000097:blood
chemical_list: D003497:Cyclic N-Oxides; D016166:Free Radical Scavengers; D009842:Oligopeptides; D011092:Polyethylene Glycols; D008315:Malondialdehyde; C047981:arginyl-glycyl-aspartic acid; D013482:Superoxide Dismutase; C003959:TEMPO