title: Calcium sensing in exocytosis.
abstract: Neurotransmitters, neuropeptides and hormones are released through regulated exocytosis of synaptic vesicles and large dense core vesicles. This complex and highly regulated process is orchestrated by SNAREs and their associated proteins. The triggering signal for regulated exocytosis is usually an increase in intracellular calcium levels. Besides the triggering role, calcium signaling modulates the precise amount and kinetics of vesicle release. Thus, it is a central question to understand the molecular machineries responsible for calcium sensing in exocytosis. Here we provide an overview of our current understanding of calcium sensing in neurotransmitter release and hormone secretion.
authors.affiliation: Laboratory of Metabolic Medicine, Singapore Bioimaging Consortium, Agency for Science, Technology and Research, Singapore. natalia.neth@gmail.com
authors.forename: Natalia
authors.initials: N
authors.lastname: Gustavsson
authors.forename: Bingbing
authors.initials: B
authors.lastname: Wu
authors.forename: Weiping
authors.initials: W
authors.lastname: Han
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D020013:Calcium Signaling; D005089:Exocytosis; D006728:Hormones / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D009479:Neuropeptides / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000378:metabolism
chemical_list: D006728:Hormones; D009479:Neuropeptides; D018377:Neurotransmitter Agents; D002118:Calcium