title: [Determination of blood markers and inflammation in subjects with impaired glucose tolerance].
abstract: OBJECTIVE
  This study was designed to explore the presence of a prothrombotic state, fibrinolytic dysfunction and inflammation in impaired glucose tolerance subjects, by evaluating serum markers of thrombosis, fibrinolysis and inflammation.
  
  
  METHODS
  In 48 consecutive adults, 25 patients with impaired glucose tolerance (nine men and 16 women, 50.0 ± 9.2 years) were compared with 23 control subjects (six men and 17 women, 48.0 ± 11 years). The markers of thrombotic activation used were D-dimer and fibrinogen. Fibrinolysis dysfunction was evaluated with plasminogen activator inhibitor 1 (PAI-1) and the inflammatory marker studied was hs-C reactive protein (hs-CRP).
  
  
  RESULTS
  The markers of thrombotic state were significantly higher in patients with impaired glucose tolerance (IGT) than in controls: D dimer (489.6 ± 277.3 vs. 345.8 ± 158.9 ng/mL) (p< 0.01) and fibrinogen (317.7 ± 32.1 vs. 266.7 ± 25.4 mg/dL) (p < 0.0001). Fibrinolytic marker PAI-1 also differed significantly between the two study groups (66.4 ± 30.7 vs. 35.5 ± 31.0 ng/mL) (p < 0.006). However, hs-CRP, as inflammation marker, (0.45 ± 0.62 mg/dL vs. 0.38 ± 0.47) did not differ significantly between the two study groups (<0.28).
  
  
  CONCLUSIONS
  This result suggests the presence of a prothrombotic state with fibrinolytic dysfunction in subjects with impaired glucose tolerance.
authors.affiliation: Hospital Centro de Salud Zenón J. Santillán. Facultad de Medicina. Universidad Nacional de Tucumán, Tucumán, Argentina.
authors.forename: Héctor
authors.initials: H
authors.lastname: Lucas-Luciardi
authors.forename: Sofia G
authors.initials: SG
authors.lastname: Berman
authors.forename: Sergio
authors.initials: S
authors.lastname: Chain
authors.forename: Gabriela
authors.initials: G
authors.lastname: Feldman
authors.forename: Ramón N
authors.initials: RN
authors.lastname: Herrera
authors.forename: Juan A
authors.initials: JA
authors.lastname: Muntaner
authors.forename: Enrique J
authors.initials: EJ
authors.lastname: del Pino
authors.forename: Jesús
authors.initials: J
authors.lastname: Martínez-Reding
authors.forename: Carlos R
authors.initials: CR
authors.lastname: Martínez-Sánchez
mesh_terms: D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003430:Cross-Sectional Studies; D005260:Female; D018149:Glucose Intolerance / Q000097:blood* / Q000150:complications; D006801:Humans; D007249:Inflammation / Q000097:blood* / Q000150:complications; D008297:Male; D008875:Middle Aged; D013927:Thrombosis / Q000097:blood* / Q000150:complications
chemical_list: D015415:Biomarkers