title: Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in the heart.
abstract: Aim of this review is to give an overview and discuss recent findings on the role of Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) in the heart. Special attention is drawn to excitation-contraction coupling (ECC) and excitation-transcription coupling (ETC). Because CaMKII expression and activity are increased in cardiac hypertrophy, heart failure, and during arrhythmias both in animal models as well as in the human heart a clinical significance of CaMKII is implied.
authors.affiliation: Department of Cardiology and Pneumology/Heart Center, Georg-August-University Göttingen, Germany. lmaier@med.uni-goettingen.de
authors.forename: Lars S
authors.initials: LS
authors.lastname: Maier
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000209:etiology; D002118:Calcium / Q000378:metabolism; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2 / Q000502:physiology*; D004789:Enzyme Activation; D056966:Excitation Contraction Coupling; D006801:Humans; D009206:Myocardium / Q000201:enzymology*; D015221:Potassium Channels / Q000502:physiology; D012519:Sarcoplasmic Reticulum / Q000378:metabolism; D015222:Sodium Channels / Q000502:physiology
chemical_list: D015221:Potassium Channels; D015222:Sodium Channels; D054732:Calcium-Calmodulin-Dependent Protein Kinase Type 2; D002118:Calcium