title: Molecular logic underlying chromosomal translocations, random or non-random?
abstract: Chromosomal translocations serve as essential diagnostic markers and therapeutic targets for leukemia, lymphoma, and many types of solid tumors. Understanding the mechanisms of chromosomal translocation generation has remained a central biological question for decades. Rather than representing a random event, recent studies indicate that chromosomal translocation is a non-random event in a spatially regulated, site-specific, and signal-driven manner, reflecting actions involved in transcriptional activation, epigenetic regulation, three-dimensional nuclear architecture, and DNA damage-repair. In this review, we will focus on the progression toward understanding the molecular logic underlying chromosomal translocation events and implications of new strategies for preventing chromosomal translocations.
authors.affiliation: Howard Hughes Medical Institute, University of California, San Diego, School of Medicine, La Jolla, California, USA.
authors.forename: Chunru
authors.initials: C
authors.lastname: Lin
authors.forename: Liuqing
authors.initials: L
authors.lastname: Yang
authors.forename: Michael G
authors.initials: MG
authors.lastname: Rosenfeld
mesh_terms: D014408:Biomarkers, Tumor / Q000235:genetics; D002869:Chromosome Aberrations; D053903:DNA Breaks, Double-Stranded; D004260:DNA Repair; D004251:DNA Transposable Elements / Q000235:genetics; D042822:Genomic Instability / Q000235:genetics*; D006801:Humans; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic
chemical_list: D014408:Biomarkers, Tumor; D004251:DNA Transposable Elements