title: Cytotoxic dimeric indole alkaloids from Catharanthus roseus.
abstract: Three new dimeric indole alkaloids (1-3), together with five known ones (4-8), were isolated from the whole plants of Catharanthus roseus. The structures and absolute configurations of new compounds were elucidated by means of NMR and CD analyses. All these compounds were evaluated for their in vitro cytotoxic activities against human breast cancer cell line MDA-MB-231.
authors.affiliation: Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, PR China.
authors.forename: Chun-Hua
authors.initials: CH
authors.lastname: Wang
authors.forename: Guo-Cai
authors.initials: GC
authors.lastname: Wang
authors.forename: Ying
authors.initials: Y
authors.lastname: Wang
authors.forename: Xiao-Qi
authors.initials: XQ
authors.lastname: Zhang
authors.forename: Xiao-Jun
authors.initials: XJ
authors.lastname: Huang
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Zhang
authors.forename: Min-Feng
authors.initials: MF
authors.lastname: Chen
authors.forename: Wen-Cai
authors.initials: WC
authors.lastname: Ye
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy*; D030008:Catharanthus / Q000737:chemistry*; D045744:Cell Line, Tumor; D005260:Female; D006801:Humans; D026121:Indole Alkaloids / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D015394:Molecular Structure; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: C575167:14',15'-didehydrocyclovinblastine; C575168:17-deacetoxycyclovinblastine; C575169:17-deacetoxyvinamidine; D000972:Antineoplastic Agents, Phytogenic; D026121:Indole Alkaloids; D010936:Plant Extracts