title: Activation procedures in the electroencephalograms of healthy and epileptic cats under propofol anaesthesia.
abstract: The current study evaluated the diagnostic value of electroencephalographic recordings (EEG) in cats with epilepsy under special consideration of photic stimulation and hyperventilation. EEGs in six healthy cats were recorded under light (mean dose of 0.23 mg/kg/min) and deep (mean dose of 0.7 mg/kg/min) propofol anaesthesia, whereas EEGs in 13 diseased cats were recorded under a propofol anaesthesia which was kept as light as possible (mean dose of 0.39 mg/kg/min). Paroxysmal discharges were detected in six of 13 cats suffering from seizures (two cats with idiopathic epilepsy and four cats with symptomatic epilepsy). Activation techniques did not enhance the diagnostic value of the EEGs. Photic driving was detected in one of six healthy cats under light, in five of six healthy cats under deep propofol anaesthesia and in 11 of 13 cats with seizures. Systematic use of activation techniques does not seem to increase the diagnostic yield of the recorded EEGs and should not be used in a clinical setting until future studies indicate value. Further investigations into the origin of photic driving under propofol anaesthesia are needed and could lead to the development of a reliable animal model to research into drug effects on the EEG.
authors.affiliation: Department of Small Animal Medicine and Surgery, University of Veterinary Medicine Hannover, Germany, Bünteweg 9, D - 30559 Hannover, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Brauer
authors.forename: S B R
authors.initials: SB
authors.lastname: Kästner
authors.forename: A M
authors.initials: AM
authors.lastname: Kulka
authors.forename: A
authors.initials: A
authors.lastname: Tipold
mesh_terms: D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D000818:Animals; D002371:Cat Diseases / Q000175:diagnosis*; D002415:Cats; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography / Q000187:drug effects / Q000662:veterinary*; D004827:Epilepsy / Q000175:diagnosis / Q000662:veterinary*; D005260:Female; D006985:Hyperventilation / Q000662:veterinary; D008297:Male; D010775:Photic Stimulation; D015742:Propofol / Q000494:pharmacology*
chemical_list: D018686:Anesthetics, Intravenous; D015742:Propofol