title: Effects of nanostructurized silicon on proliferation of stem and cancer cell.
abstract: In vitro experiments showed that stem and cancer cells retained their viability on the surface of porous silicon with 10-100 nm nanostructures, but their proliferation was inhibited. Silicon nanoparticles of 100 nm in size obtained by mechanical grinding of porous silicon films or crystal silicon plates in a concentration below 1 mg/ml in solution did not modify viability and proliferation of mouse fibroblast and human laryngeal cancer cells. Additional ultrasonic exposure of cancer cells in the presence of 1 mg/ml silicon nanoparticles added to nutrient medium led to complete destruction of cells or to the appearance of membrane defects blocking their proliferation and initiating their apoptotic death.
authors.affiliation: Physical Faculty, M. V. Lomonosov Moscow University, Moscow, Russia. osminkina@vega.phys.msu.ru
authors.forename: L A
authors.initials: LA
authors.lastname: Osminkina
authors.forename: E N
authors.initials: EN
authors.lastname: Luckyanova
authors.forename: M B
authors.initials: MB
authors.lastname: Gongalsky
authors.forename: A A
authors.initials: AA
authors.lastname: Kudryavtsev
authors.forename: A Kh
authors.initials: AKh
authors.lastname: Gaydarova
authors.forename: R A
authors.initials: RA
authors.lastname: Poltavtseva
authors.forename: P K
authors.initials: PK
authors.lastname: Kashkarov
authors.forename: V Yu
authors.initials: VY
authors.lastname: Timoshenko
authors.forename: G T
authors.initials: GT
authors.lastname: Sukhikh
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D002452:Cell Count; D002453:Cell Cycle / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D055664:Electrochemical Techniques; D005333:Fetus; D006801:Humans; D007822:Laryngeal Neoplasms / Q000378:metabolism / Q000473:pathology; D051379:Mice; D041681:NIH 3T3 Cells; D053758:Nanoparticles / Q000737:chemistry; D010316:Particle Size; D016062:Porosity; D012825:Silicon / Q000737:chemistry / Q000494:pharmacology*; D013010:Sonication; D013234:Stem Cells / Q000166:cytology* / Q000187:drug effects; D014407:Tumor Cells, Cultured
chemical_list: D012825:Silicon