title: Management and outcome of salivary duct carcinoma in major salivary glands.
abstract: Salivary duct carcinoma (SDC) is a rare and aggressive malignancy with poor prognosis. Its histomorphology is distinctly reminiscent of the ductal carcinoma of the breast. We reviewed the treatment and outcome of SDCs at a single tertiary care centre. Twenty-five cases of SDC of major salivary gland origin, diagnosed and treated at the Department of Otolaryngology, Head and Neck Surgery, Helsinki University Central Hospital, Helsinki, Finland, during a 14-year period from 1997 to 2011, were reviewed retrospectively. Survival outcome was analyzed for 18 patients with a minimum follow-up of 24 months. There were 16 male (64 %) and 9 female (36 %) patients with a median age of 61 years (range 36-82 years). The majority of the cases occurred in the parotid gland (n = 21, 84 %) followed by the submandibular gland (n = 4, 16 %). The primary treatment consisted of surgical resection in all cases and 17 (68 %) patients also underwent neck dissection. Most of the patients (n = 18, 72 %) were treated with postoperative radiotherapy. Seven patients (28 %) had a disease recurrence within a median follow-up time of 15 months (range 3-27 months). In the group (n = 18) with a minimum follow-up time of 24 months, the 2- and 5-year overall and disease-specific survival rates were 66, 41 % and 75, 55 %, respectively. These results confirm the aggressive nature of SDCs in major salivary glands. Diagnostics and management of these tumours need to be centralized in experienced surgical Head and Neck Oncology Centres, and new treatment strategies should be investigated.
authors.affiliation: Department of Otolaryngology, Head and Neck Surgery, Helsinki University Central Hospital, University of Helsinki, P.O. Box 220, 00029 HUCH, Helsinki, Finland.
authors.forename: Elina
authors.initials: E
authors.lastname: Salovaara
authors.forename: Olli
authors.initials: O
authors.lastname: Hakala
authors.forename: Leif
authors.initials: L
authors.lastname: Bäck
authors.forename: Petri
authors.initials: P
authors.lastname: Koivunen
authors.forename: Kauko
authors.initials: K
authors.lastname: Saarilahti
authors.forename: Fabricio
authors.initials: F
authors.lastname: Passador-Santos
authors.forename: Ilmo
authors.initials: I
authors.lastname: Leivo
authors.forename: Antti A
authors.initials: AA
authors.lastname: Mäkitie
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D012189:Retrospective Studies; D018987:Salivary Ducts / Q000473:pathology; D012468:Salivary Gland Neoplasms / Q000473:pathology / Q000628:therapy*; D015996:Survival Rate; D016896:Treatment Outcome