title: Evaluation of serum oxidant/antioxidant balance in multiple sclerosis.
abstract: The total oxidative status (TOS)/total anti-oxidative status (TAS) ratio can provide information on an individual's absolute oxidative stress index (OSI). We investigated the alterations in the oxidant-antioxidant balance by measuring the oxidant parameters OSI, TOS, and malondialdehyde (MDA) together with the antioxidant parameters such as TAS, and superoxide dismutase (SOD) in patients with relapsing remitting multiple sclerosis (MS). To our knowledge, this is the first study to evaluate OSI in patients with relapsing remitting MS. 35 ambulatory patients with relapsing-remitting MS (35.8 ± 8.7 years) and 32 age- and activity-matched healthy control subjects (35.1 ± 3.7 years) that participated in the study. Serum TAS and TOS levels were determined using new automated methods. MS patients had higher concentrations of MDA (151.5 ± 51.1 vs. 111.3 ± 27.4 nmol/g protein, respectively; p < 0.001), TOS (148.1 ± 162.5 vs. 48.3 ± 46.4 mmol H(2)O(2) Equiv./g protein, respectively; p = 0.002), OSI (21124 ± 32543 vs. 5294 ± 5562, respectively; p = 0.008), and SOD (4.5 ± 0.7 vs. 3.4 ± 0.6 U/L, respectively; p < 0.001) compared with healthy controls. On the other hand, MS patients had lower concentrations of NO (12.3 ± 6.9 vs. 17.4 ± 2.5 μmol/g protein, respectively; p < 0.001) and TAS (0.82 ± 0.27 vs. 0.26 ± 0.15, respectively; p = 0.011) compared with healthy controls. In conclusion, these findings indicate that the oxidative stress plays an important role in the pathogenesis of MS.
authors.affiliation: Department of Neurology, Faculty of Medicine, School of Medicine, Dicle University, 21280 Diyarbakır, Turkey. drabdullahacar@hotmail.com
authors.forename: Abdullah
authors.initials: A
authors.lastname: Acar
authors.forename: M
authors.initials: M
authors.lastname: Ugur Cevik
authors.forename: Osman
authors.initials: O
authors.lastname: Evliyaoglu
authors.forename: Ertugrul
authors.initials: E
authors.lastname: Uzar
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Tamam
authors.forename: Adalet
authors.initials: A
authors.lastname: Arıkanoglu
authors.forename: Yavuz
authors.initials: Y
authors.lastname: Yucel
authors.forename: Sefer
authors.initials: S
authors.lastname: Varol
authors.forename: Hakan
authors.initials: H
authors.lastname: Onder
authors.forename: Nebahat
authors.initials: N
authors.lastname: Taşdemir
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D009103:Multiple Sclerosis / Q000097:blood* / Q000503:physiopathology; D009569:Nitric Oxide / Q000097:blood; D016877:Oxidants / Q000097:blood*; D010084:Oxidation-Reduction; D018384:Oxidative Stress / Q000502:physiology; D013482:Superoxide Dismutase / Q000097:blood; D055815:Young Adult
chemical_list: D000975:Antioxidants; D016877:Oxidants; D009569:Nitric Oxide; D008315:Malondialdehyde; D013482:Superoxide Dismutase