title: Pneumatosis intestinalis in pediatric hematopoietic stem cell transplantation patients: an uncommon complication.
abstract: Hematopoietic stem cell transplantation (HSCT) causes many complications including the development of graft-versus-host disease (GVHD). Pneumatosis intestinalis (PI), a rare side affect in patients with post-HSCT GVHD, is uncommonly seen in non-neonatal patients. In neonates, surgical intervention is common, yet in non-neonatal patients, medical management is advisable. We present four pediatric patients who post-HSCT developed GVHD and subsequently PI. Surgery was performed on one patient while the other three were successfully managed conservatively. Although PI is rare in this group of patients, clinicians should be aware of this post-HSCT complication to ensure early diagnosis and proper management.
authors.affiliation: Department of Pathology, Children's Healthcare of Atlanta, Atlanta, Georgia 30322, USA.
authors.forename: Sarah Catherine
authors.initials: SC
authors.lastname: Shulman
authors.forename: Frances
authors.initials: F
authors.lastname: Chiang
authors.forename: Ann E
authors.initials: AE
authors.lastname: Haight
authors.forename: Charlotte Katherine
authors.initials: CK
authors.lastname: Steelman
authors.forename: Kuang-Yueh
authors.initials: KY
authors.lastname: Chiang
authors.forename: Kenneth
authors.initials: K
authors.lastname: Gow
authors.forename: Bahig M
authors.initials: BM
authors.lastname: Shehata
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D013505:Digestive System Surgical Procedures; D005260:Female; D006086:Graft vs Host Disease / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D006801:Humans; D007223:Infant; D011006:Pneumatosis Cystoides Intestinalis / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D011183:Postoperative Complications; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D014184:Transplantation, Homologous; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents