title: Abstinence and 'low-risk' consumption 1 year after the initiation of high-dose baclofen: a retrospective study among 'high-risk' drinkers.
abstract: OBJECTIVE
  The aim of the study was to assess the proportions of 'high-risk' drinkers' abstinent or with 'low-risk' consumption levels 1 year after the initiation of high-dose baclofen.
  
  
  METHODS
  This is a retrospective 'open' study; the outcome of this study was to assess the level of alcohol consumption in the 12th month of treatment.
  
  
  RESULTS
  Of the 181 patients included, a follow-up evaluation was possible in 132 patients. The initial alcohol consumption of the 132 patients analysed averaged 182 ± 92 g/day. After 1 year, 80% of the 132 (i.e. 58% of 181) were either abstinent (n = 78) or drinking at low-risk levels (n = 28) in their 12th month of treatment. The mean baclofen dose at 1 year was 129 ± 71 mg/day.
  
  
  CONCLUSIONS
  High-dose baclofen should be tested in randomized placebo-controlled trials among high-risk drinkers.
authors.affiliation: Département de Médecine Générale, Faculté de Médecine Paris Descartes--Site Cochin, Université Paris Descartes, 24, rue du Faubourg Saint-Jacques, Sorbonne Paris Cité, 75014 Paris, France. laurent.rigal@parisdescartes.fr
authors.forename: Laurent
authors.initials: L
authors.lastname: Rigal
authors.forename: Constance
authors.initials: C
authors.lastname: Alexandre-Dubroeucq
authors.forename: Renaud
authors.initials: R
authors.lastname: de Beaurepaire
authors.forename: Claire
authors.initials: C
authors.lastname: Le Jeunne
authors.forename: Philippe
authors.initials: P
authors.lastname: Jaury
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000188:drug therapy*; D000437:Alcoholism / Q000188:drug therapy*; D001418:Baclofen / Q000627:therapeutic use*; D005260:Female; D058786:GABA-B Receptor Agonists / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012306:Risk; D013695:Temperance / Q000706:statistics & numerical data*
chemical_list: D058786:GABA-B Receptor Agonists; D001418:Baclofen