title: Implication of conjugated linoleic acid (CLA) in human health.
abstract: Conjugated linoleic acid (CLA) has drawn significant attention in the last two decades for its variety of biologically beneficial effects. CLA reduces body fat, cardiovascular diseases and cancer, and modulates immune and inflammatory responses as well as improves bone mass. It has been suggested that the overall effects of CLA are the results of interactions between two major isomers, cis-9,trans-11 and trans-10,cis-12. This review will primarily focus on current CLA publications involving humans, which are also summarized in the tables. Along with a number of beneficial effects of CLA, there are safety considerations for CLA supplementation in humans, which include effects on liver functions, milk fat depression, glucose metabolism, and oxidative stresses.
authors.affiliation: Department of Food Science, University of Massachusetts, Amherst, Amherst , MA 01003, USA.
authors.forename: Allison
authors.initials: A
authors.lastname: Dilzer
authors.forename: Yeonhwa
authors.initials: Y
authors.lastname: Park
mesh_terms: D000818:Animals; D004032:Diet; D019587:Dietary Supplements; D015444:Exercise; D006801:Humans; D044243:Linoleic Acids, Conjugated / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D009765:Obesity / Q000188:drug therapy
chemical_list: D044243:Linoleic Acids, Conjugated