title: Standard guidelines for the chromosome-centric human proteome project.
abstract: The objective of the international Chromosome-Centric Human Proteome Project (C-HPP) is to map and annotate all proteins encoded by the genes on each human chromosome. The C-HPP consortium was established to organize a collaborative network among the research teams responsible for protein mapping of individual chromosomes and to identify compelling biological and genetic mechanisms influencing colocated genes and their protein products. The C-HPP aims to foster the development of proteome analysis and integration of the findings from related molecular -omics technology platforms through collaborations among universities, industries, and private research groups. The C-HPP consortium leadership has elicited broad input for standard guidelines to manage these international efforts more efficiently by mobilizing existing resources and collaborative networks. The C-HPP guidelines set out the collaborative consensus of the C-HPP teams, introduce topics associated with experimental approaches, data production, quality control, treatment, and transparency of data, governance of the consortium, and collaborative benefits. A companion approach for the Biology and Disease-Driven HPP (B/D-HPP) component of the Human Proteome Project is currently being organized, building upon the Human Proteome Organization's organ-based and biofluid-based initiatives (www.hupo.org/research). The common application of these guidelines in the participating laboratories is expected to facilitate the goal of a comprehensive analysis of the human proteome.
authors.affiliation: Yonsei Proteome Research Center and Department of Integrated Omics for Biomedical Science, World Class University Program, Yonsei University, Seoul, Korea. paikyk@yonsei.ac.kr
authors.forename: Young-Ki
authors.initials: YK
authors.lastname: Paik
authors.forename: Gilbert S
authors.initials: GS
authors.lastname: Omenn
authors.forename: Mathias
authors.initials: M
authors.lastname: Uhlen
authors.forename: Samir
authors.initials: S
authors.lastname: Hanash
authors.forename: György
authors.initials: G
authors.lastname: Marko-Varga
authors.forename: Ruedi
authors.initials: R
authors.lastname: Aebersold
authors.forename: Amos
authors.initials: A
authors.lastname: Bairoch
authors.forename: Tadashi
authors.initials: T
authors.lastname: Yamamoto
authors.forename: Pierre
authors.initials: P
authors.lastname: Legrain
authors.forename: Hyoung-Joo
authors.initials: HJ
authors.lastname: Lee
authors.forename: Keun
authors.initials: K
authors.lastname: Na
authors.forename: Seul-Ki
authors.initials: SK
authors.lastname: Jeong
authors.forename: Fuchu
authors.initials: F
authors.lastname: He
authors.forename: Pierre-Alain
authors.initials: PA
authors.lastname: Binz
authors.forename: Toshihide
authors.initials: T
authors.lastname: Nishimura
authors.forename: Paul
authors.initials: P
authors.lastname: Keown
authors.forename: Mark S
authors.initials: MS
authors.lastname: Baker
authors.forename: Jong Shin
authors.initials: JS
authors.lastname: Yoo
authors.forename: Jerome
authors.initials: J
authors.lastname: Garin
authors.forename: Alexander
authors.initials: A
authors.lastname: Archakov
authors.forename: John
authors.initials: J
authors.lastname: Bergeron
authors.forename: Ghasem Hosseini
authors.initials: GH
authors.lastname: Salekdeh
authors.forename: William S
authors.initials: WS
authors.lastname: Hancock
mesh_terms: D002877:Chromosomes, Human; D030562:Databases, Protein / Q000592:standards*; D017408:Guidelines as Topic; D016045:Human Genome Project; D006801:Humans; D013058:Mass Spectrometry; D020543:Proteome / Q000032:analysis*; D040901:Proteomics / Q000379:methods* / Q000592:standards*; D012107:Research Design
chemical_list: D020543:Proteome