title: Antidepressant activity of diterpene alkaloids of Aconitum baicalense Turcz.
abstract: Course treatment with diterpene alkaloids of Aconitum baicalense in mice reduced the time of immobilization in the tail suspension test and produced an antiexudative effect in mouse model of serotonin-induced edema. In the open field test, application of alkaloids did not change the total motor activity, orientation and exploratory behavior, and emotional reactions of animals. Experimental data suggest that diterpene alkaloids of Aconitum baicalensis exhibit antidepressant properties, possibly due to modulation of sensitivity to serotonin.
authors.affiliation: Laboratory of Phytopharmacology, Institute of Pharmacology, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia. nesyuliya@yandex.ru
authors.forename: Yu V
authors.initials: YV
authors.lastname: Nesterova
authors.forename: T N
authors.initials: TN
authors.lastname: Povetieva
authors.forename: N I
authors.initials: NI
authors.lastname: Suslov
authors.forename: A A
authors.initials: AA
authors.lastname: Semenov
authors.forename: S V
authors.initials: SV
authors.lastname: Pushkarskiy
mesh_terms: D031841:Aconitum / Q000737:chemistry*; D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D004224:Diterpenes / Q000494:pharmacology*; D005260:Female; D051379:Mice; D012701:Serotonin / Q000008:administration & dosage
chemical_list: D000470:Alkaloids; D000928:Antidepressive Agents; D004224:Diterpenes; D012701:Serotonin