title: Absorption, disposition and pharmacokinetics of nanoemulsions.
abstract: Nanoemulsions are composed of nanoscale droplets of one immiscible liquid dispersed within another, which have been the focus of extensive research worldwide due to their solubilization and transportation capacity of both hydrophobic and hydrophilic active compounds with unique physical properties. In a broad sense, submicron-emulsion, microemulsion, self-microemulsifing drug delivery system, lipid emulsion and cholesterol-rich microemulsion (LDE) all belong to nanoemulsions. The review starts with a brief introduction to the definition, formulation rationale, and types of nanoemulaions, and focused on, by different administration routes such as the oral, intravenous, transdermal, ocular nasal and rectal routes, the absorption, disposition, pharmacokinetics properties of nanoemulsions.
authors.affiliation: Department of Pharmaceutics, School of Pharmacy, Fudan University, Zhangheng Road 826, Shanghai, PR China. wuwei@shmu.edu.cn
authors.forename: Yi
authors.initials: Y
authors.lastname: Lu
authors.forename: Jianping
authors.initials: J
authors.lastname: Qi
authors.forename: Wei
authors.initials: W
authors.lastname: Wu
mesh_terms: D000042:Absorption; D000818:Animals; D004337:Drug Carriers / Q000493:pharmacokinetics*; D004655:Emulsions / Q000493:pharmacokinetics*; D006801:Humans; D049329:Nanostructures; D004364:Pharmaceutical Preparations / Q000378:metabolism; D014018:Tissue Distribution
chemical_list: D004337:Drug Carriers; D004655:Emulsions; D004364:Pharmaceutical Preparations