title: Comparison of preoperative images with gross and histopathological findings of liver slices in patients with liver metastases from colorectal cancer after chemotherapy.
abstract: OBJECTIVE
  Since there is a difference in the slice thickness between preoperative images of liver metastases (1-3mm slices) and surgical liver pathology specimens (5mm slices), micrometastases may not be detected in these specimens. In addition, the accuracy of preoperative imaging for the detection of metastases degenerated by chemotherapy is unclear.
  
  
  METHODS
  Five patients with liver metastases from colorectal cancer who had received adjuvant chemotherapy and undergone hepatectomy were included. The whole resected liver was sliced at approximately 1mm intervals and the slices were examined carefully for gross lesions. The preoperative CT and EOB-MRI findings of each lesion were compared with gross and histopathological findings.
  
  
  RESULTS
  The accuracy of EOB-MRI was higher than that of CT for the detection of liver metastases. The number of lesions detected on EOB-MRI was in agreement with that of histopathologically proven liver metastases in 4 of the 5 patients. All lesions that were grossly identified but turned out to be non-neoplastic were regenerative nodules associated with drug-induced liver injury or lobular nodules associated with marked fatty change, measuring about 1mm in diameter.
  
  
  CONCLUSIONS
  EOB-MRI was the most accurate method for the preoperative detection of liver metastases, enabling the visualization of almost all liver metastases.
authors.affiliation: Department of Digestive Surgery, Tokyo Medical University, Tokyo, Japan. kasuya-k@jcom.home.ne.jp
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Kasuya
authors.forename: Hisashi
authors.initials: H
authors.lastname: Oshiro
authors.forename: Kazuhiiro
authors.initials: K
authors.lastname: Saito
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Satoru
authors.initials: S
authors.lastname: Kikuchi
authors.forename: Bunso
authors.initials: B
authors.lastname: Kyo
authors.forename: Takaaki
authors.initials: T
authors.lastname: Matsudo
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Nagakawa
authors.forename: Takao
authors.initials: T
authors.lastname: Itoi
authors.forename: Akihiko
authors.initials: A
authors.lastname: Tsuchida
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D015179:Colorectal Neoplasms / Q000188:drug therapy / Q000473:pathology*; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology*; D008113:Liver Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed
chemical_list: D000970:Antineoplastic Agents