title: Hepatitis E virus-associated aplastic anaemia: the first case of its kind.
abstract: Here we report the case of a 32-year-old Pakistani male, who developed severe aplastic anaemia after a severe attack of acute hepatitis E virus (HEV) infection. His laboratory test values were not in normal ranges. The liver enzymes were elevated. Serologic and/or molecular-based tests for hepatitis A, B, C, D, G, transfusion transmitted virus (TTV) and B19 were negative, whereas anti-HEV IgM and HEV RNA polymerase chain reaction (PCR) was also detected in the patient sample. The patient received immunosuppressive therapy for 6 months; however, he did not show response to this kind of therapy. The results of our case clearly show the causative role of HEV in the development of aplastic anaemia that might not be ignored.
authors.affiliation: Hematology Department, Sheikh Zayed Medical Complex, Lahore, Pakistan.
authors.forename: Shahida Amjad Riaz
authors.initials: SA
authors.lastname: Shah
authors.forename: Amreek
authors.initials: A
authors.lastname: Lal
authors.forename: Muhammad
authors.initials: M
authors.lastname: Idrees
authors.forename: Abrar
authors.initials: A
authors.lastname: Hussain
authors.forename: Charan
authors.initials: C
authors.lastname: Jeet
authors.forename: Fayyaz A
authors.initials: FA
authors.lastname: Malik
authors.forename: Zafar
authors.initials: Z
authors.lastname: Iqbal
authors.forename: Habib ur
authors.initials: Hu
authors.lastname: Rehman
mesh_terms: D000328:Adult; D000741:Anemia, Aplastic / Q000175:diagnosis* / Q000473:pathology; D016751:Hepatitis E / Q000150:complications*; D016752:Hepatitis E virus / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D010154:Pakistan