title: Characteristics and treatment of seizures in patients with high-grade glioma: a review.
abstract: High-grade gliomas (HGGs), including anaplastic astrocytoma and glioblastoma multiforme, are the most common primary brain tumors, and are often associated with seizures. Seizure control is a critical but often underappreciated goal in the treatment of patients harboring these malignant lesions. Patients with HGG who also have medically intractable seizures should be considered for a palliative resection guided by electrocorticography and functional mapping. Antiepileptic drugs remain the mainstay of seizure treatment in HGG, and antiepileptic medication should be started after a tumor-related seizure, but should not be used prophylactically in the absence of seizure activity.
authors.affiliation: UCSF Epilepsy Center, University of California, San Francisco, 505 Parnassus Avenue, Box 0138, San Francisco, CA 94143, USA. EnglotDJ@neurosurg.ucsf.edu
authors.forename: Dario J
authors.initials: DJ
authors.lastname: Englot
authors.forename: Mitchel S
authors.initials: MS
authors.lastname: Berger
authors.forename: Edward F
authors.initials: EF
authors.lastname: Chang
authors.forename: Paul A
authors.initials: PA
authors.lastname: Garcia
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000150:complications*; D005910:Glioma / Q000150:complications*; D006801:Humans; D012307:Risk Factors; D012640:Seizures / Q000188:drug therapy* / Q000209:etiology*
chemical_list: D000927:Anticonvulsants