title: NecroX-5 prevents hypoxia/reoxygenation injury by inhibiting the mitochondrial calcium uniporter.
abstract: OBJECTIVE
  Preservation of mitochondrial function is essential to limit myocardial damage in ischaemic heart disease. We examined the protective effects and mechanism of a new compound, NecroX-5, on rat heart mitochondria in a hypoxia/reoxygenation (HR) model.
  
  
  RESULTS
  NecroX-5 reduced mitochondrial oxidative stress, prevented the collapse in mitochondrial membrane potential, improved mitochondrial oxygen consumption, and suppressed mitochondrial Ca(2+) overload during reoxygenation in an in vitro rat heart HR model. Furthermore, NecroX-5 reduced the ouabain- or histamine-induced increase in mitochondrial Ca(2+).
  
  
  CONCLUSIONS
  These findings suggest that NecroX-5 may act as a mitochondrial Ca(2+) uniporter inhibitor to protect cardiac mitochondria against HR damage.
authors.affiliation: Department of Physiology, Inje University, Busan 613-735, Republic of Korea.
authors.forename: Vu Thi
authors.initials: VT
authors.lastname: Thu
authors.forename: Hyoung-Kyu
authors.initials: HK
authors.lastname: Kim
authors.forename: Le Thanh
authors.initials: le T
authors.lastname: Long
authors.forename: Sung-Ryul
authors.initials: SR
authors.lastname: Lee
authors.forename: Tran My
authors.initials: TM
authors.lastname: Hanh
authors.forename: Tae Hee
authors.initials: TH
authors.lastname: Ko
authors.forename: Hye-Jin
authors.initials: HJ
authors.lastname: Heo
authors.forename: Nari
authors.initials: N
authors.lastname: Kim
authors.forename: Soon Ha
authors.initials: SH
authors.lastname: Kim
authors.forename: Kyung Soo
authors.initials: KS
authors.lastname: Ko
authors.forename: Byoung Doo
authors.initials: BD
authors.lastname: Rhee
authors.forename: Jin
authors.initials: J
authors.lastname: Han
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism; D015220:Calcium Channels / Q000187:drug effects*; D006321:Heart / Q000187:drug effects / Q000502:physiology; D006576:Heterocyclic Compounds, 4 or More Rings / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D008929:Mitochondria, Heart / Q000187:drug effects* / Q000378:metabolism; D015428:Myocardial Reperfusion Injury / Q000378:metabolism / Q000517:prevention & control*; D009206:Myocardium / Q000378:metabolism*; D018384:Oxidative Stress / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D017382:Reactive Oxygen Species / Q000378:metabolism; D013450:Sulfones / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000975:Antioxidants; D015220:Calcium Channels; D006576:Heterocyclic Compounds, 4 or More Rings; C574766:NecroX-5; D017382:Reactive Oxygen Species; D013450:Sulfones; C034703:mitochondrial calcium uniporter; D002118:Calcium