title: Interaction between debrisoquine and phenylephrine in man.
abstract: 1 The interaction between phenylephrine and debrisoquine was studied using normal and hypertensive human volunteers, measuring blood pressure, pulse rate and pupil diameter. Single doses of phenylephrine were given before, during and after a short course of debrisoquine treatment. 2 The circulatory effects of phenylephrine are potentiated by debrisoquine; in a few subjects this potentiation was marked and a potential hazard. 3 Limited deductions could be made about the effects of debrisoquine on baroceptor responses and adrenergic mechanisms.
authors.affiliation: Department of Pharmacology and Therapeutics, London Hospital Medical College, Turner Street, London.
authors.forename: W
authors.initials: W
authors.lastname: Allum
authors.forename: J
authors.initials: J
authors.lastname: Aminu
authors.forename: T H
authors.initials: TH
authors.lastname: Bloomfield
authors.forename: C
authors.initials: C
authors.lastname: Davies
authors.forename: A H
authors.initials: AH
authors.lastname: Scales
authors.forename: D W
authors.initials: DW
authors.lastname: Vere