title: Synthesis of 2,5-disubstituted oxazoles and oxazolines catalyzed by ruthenium(II) porphyrin and simple copper salts.
abstract: A novel and moderate synthesis of 2,5-disubstituted oxazoles and oxazolines involving ruthenium(II) porphyrin-copper chloride catalyzed cyclization was developed. These reactions using readily available benzene carboxylic acids and phenylethenes or phenylacetylenes are performed under mild conditions. The reactions proceed in series, giving rise to the formation of an intermolecular C-N bond and an intramolecular C-O bond, which yield oxazole or oxazoline derivatives simultaneously.
authors.affiliation: Key Laboratory of Drug-Targeting and Drug-Delivery Systems of the Ministry of Education, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan, 610041, P. R. China.
authors.forename: Chuan Long
authors.initials: CL
authors.lastname: Zhong
authors.forename: Bo Yang
authors.initials: BY
authors.lastname: Tang
authors.forename: Ping
authors.initials: P
authors.lastname: Yin
authors.forename: Yue
authors.initials: Y
authors.lastname: Chen
authors.forename: Ling
authors.initials: L
authors.lastname: He
mesh_terms: D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D008665:Metalloporphyrins / Q000737:chemistry*; D015394:Molecular Structure; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry; D012428:Ruthenium; D012492:Salts / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D008665:Metalloporphyrins; D010080:Oxazoles; D012492:Salts; D003300:Copper; D012428:Ruthenium