title: Polymorphism in the promoter region of the tumor necrosis factor-alpha gene in cattle herds naturally infected and uninfected with the bovine leukemia virus.
abstract: The objective of this study was to describe and compare the genetic structure (TNF-alpha -position 824) of dairy cattle herds infected and not infected with the bovine leukemia virus (BLV). The results of the present study indicate that BLV-positive herds were characterized by similar genetic structure (TNF-alpha -824A/G). The genetic equilibrium in these herds was preserved, but a tendency to increased frequency of G/G homozygotes was found. The genetic structure of the healthy herd differed considerably from that of leukemic herds.
authors.affiliation: Department of Animal Genetics, University of Warmia and Mazury in Olsztyn Oczapowskiego 5, 10-719 Olsztyn, Poland. b.bojarojc@uwm.edu.pl
authors.forename: B
authors.initials: B
authors.lastname: Bojarojć-Nosowicz
authors.forename: E
authors.initials: E
authors.lastname: Kaczmarczyk
authors.forename: A
authors.initials: A
authors.lastname: Stachura
authors.forename: M
authors.initials: M
authors.lastname: Kotkiewicz
mesh_terms: D000818:Animals; D002417:Cattle; D016583:Enzootic Bovine Leukosis / Q000235:genetics* / Q000821:virology; D020022:Genetic Predisposition to Disease; D001909:Leukemia Virus, Bovine; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D014409:Tumor Necrosis Factor-alpha