title: Effect of compound of gelatin hydrogel microsphere incorporated with platelet-rich-plasma and alginate on sole defect in cattle.
abstract: Platelet-rich plasma (PRP) was administered to cattle with hoof defects (10-mm drill hole) to promote sole defect healing. Two types of gels were prepared. One was a mixed gel [compound of gelatin microspheres (GM) incorporated with PRP and alginate] and was used for the test group, while the other was an alginate gel used for the control group. Each hole was filled with one of these gels. The drill hole depth, pressure pain, and hardness of the regenerated tissue were measured for 3 weeks after treatment. These measurements improved significantly in the test group than in the control group. The results suggest that a compound of GM incorporated with PRP and alginate had a hoof-regenerating effect in cattle.
authors.affiliation: Department of Clinical Veterinary Science, Obihiro University of Agriculture and Veterinary Medicine, Inada, Obihiro, Hokkaido 080-8555, Japan.
authors.forename: Nao
authors.initials: N
authors.lastname: Tsuzuki
authors.forename: Jong-Pil
authors.initials: JP
authors.lastname: Seo
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Yamada
authors.forename: Shingo
authors.initials: S
authors.lastname: Haneda
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Tabata
authors.forename: Naoki
authors.initials: N
authors.lastname: Sasaki
mesh_terms: D000464:Alginates / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000473:pathology / Q000628:therapy; D005260:Female; D005534:Foot Diseases / Q000628:therapy / Q000662:veterinary*; D005780:Gelatin / Q000737:chemistry / Q000494:pharmacology*; D020723:Glucuronic Acid / Q000737:chemistry / Q000494:pharmacology; D006603:Hexuronic Acids / Q000737:chemistry / Q000494:pharmacology; D006724:Hoof and Claw / Q000473:pathology*; D008863:Microspheres; D053657:Platelet-Rich Plasma / Q000737:chemistry*; D023822:Tissue Engineering; D014945:Wound Healing
chemical_list: D000464:Alginates; D006603:Hexuronic Acids; D020723:Glucuronic Acid; D005780:Gelatin