title: Ugi reaction-assisted rapid assembly of affinity-based probes against potential protein tyrosine phosphatases.
abstract: The multi-component Ugi reaction has been employed to assemble a small library of affinity-based probes (AfBPs) that target potential protein tyrosine phosphatases. The probes showed good labelling of PTP1B and MptpB, and were subsequently used to label endogenous PTP1B in MCF-7 cell lysates.
authors.affiliation: Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Singapore.
authors.forename: Jingyan
authors.initials: J
authors.lastname: Ge
authors.forename: Xiamin
authors.initials: X
authors.lastname: Cheng
authors.forename: Lay Pheng
authors.initials: LP
authors.lastname: Tan
authors.forename: Shao Q
authors.initials: SQ
authors.lastname: Yao
mesh_terms: D000345:Affinity Labels / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D045744:Cell Line, Tumor; D015195:Drug Design; D006801:Humans; D007700:Kinetics; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism*
chemical_list: D000345:Affinity Labels; D017027:Protein Tyrosine Phosphatases