title: Effect of locomotor training on muscle performance in the context of nerve-muscle communication dysfunction.
abstract: BACKGROUND
  The effects of locomotor training (LT) on skeletal muscle after peripheral nerve injury and acetylcholinesterase deficiency are not well documented.
  
  
  METHODS
  We determined the effects of LT on mouse soleus muscle performance after sciatic nerve transection with excision (full and permanent denervation), nerve transection (partial functional reinnervation), nerve crush (full denervation with full functional reinnervation), and acetylcholinesterase deficiency (alteration in neuromuscular junction functioning).
  
  
  RESULTS
  We found no significant effect of LT on the recovery of soleus muscle weight, maximal force in response to muscle stimulation, and fatigue resistance after nerve transection with or without excision. However, LT significantly increased soleus muscle fatigue resistance after nerve crush and acetylcholinesterase deficiency. Moreover, hindlimb immobilization significantly aggravated the deficit in soleus muscle maximal force production and atrophy after nerve crush.
  
  
  CONCLUSIONS
  LT is beneficial, and reduced muscle use is detrimental for intrinsic muscle performance in the context of disturbed nerve-muscle communication.
authors.affiliation: Université Pierre et Marie Curie-Paris, UMR-S974, Paris F-75013, France.
authors.forename: Wahiba
authors.initials: W
authors.lastname: Hadj-Saïd
authors.forename: Marie
authors.initials: M
authors.lastname: Bangratz
authors.forename: Alban
authors.initials: A
authors.lastname: Vignaud
authors.forename: Arnaud
authors.initials: A
authors.lastname: Chatonnet
authors.forename: Gillian
authors.initials: G
authors.lastname: Butler-Browne
authors.forename: Sophie
authors.initials: S
authors.lastname: Nicole
authors.forename: Onnick
authors.initials: O
authors.lastname: Agbulut
authors.forename: Arnaud
authors.initials: A
authors.lastname: Ferry
mesh_terms: D000110:Acetylcholinesterase / Q000172:deficiency; D000818:Animals; D001284:Atrophy; D004558:Electric Stimulation; D005081:Exercise Therapy; D019417:Hindlimb Suspension / Q000502:physiology; D066298:In Vitro Techniques; D007537:Isometric Contraction; D008124:Locomotion / Q000502:physiology*; D008297:Male; D051379:Mice; D009046:Motor Neurons / Q000473:pathology / Q000502:physiology*; D009119:Muscle Contraction / Q000502:physiology; D009121:Muscle Denervation; D018763:Muscle Fatigue / Q000502:physiology; D018482:Muscle, Skeletal / Q000294:innervation* / Q000473:pathology / Q000503:physiopathology*; D009409:Nerve Crush; D009468:Neuromuscular Diseases / Q000473:pathology / Q000503:physiopathology*; D009929:Organ Size; D010807:Physical Endurance / Q000502:physiology; D012584:Sciatic Nerve / Q000473:pathology
chemical_list: D000110:Acetylcholinesterase