title: Podocyte biology in segmental sclerosis and progressive glomerular injury.
abstract: During the past 2 decades, progress has been made in understanding the biology and mechanisms of podocyte injury and the relationship of these processes to glomerulosclerosis. In addition, studies of human biopsies and animal models have provided insights into the mechanisms of glomerular disease progression and repair. These new developments are critical for establishing better therapeutic guidelines that target specific pathways, which otherwise would lead to irreversible injury.
authors.affiliation: Division of Nephrology, New York University Langone Medical Center, New York, NY 10016, USA. barisl0@med.nyu.edu
authors.forename: Laura
authors.initials: L
authors.lastname: Barisoni
mesh_terms: D000818:Animals; D016922:Cellular Senescence; D018450:Disease Progression; D005260:Female; D005923:Glomerulosclerosis, Focal Segmental / Q000473:pathology*; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology*; D008297:Male; D051379:Mice; D050199:Podocytes / Q000473:pathology* / Q000502:physiology*; D051381:Rats