title: Segmentectomy for giant pulmonary sclerosing haemangiomas with high serum KL-6 levels.
abstract: We describe a 61-year old female patient with a giant pulmonary sclerosing haemangioma (PSH) and an extremely high preoperative serum KL-6 level. During an annual health screening, the patient showed a posterior mediastinal mass on chest radiography. Chest computed tomography and magnetic resonance imaging revealed a well-circumscribed 60 mm diameter nodule with a marked contrast enhancement in the left lower lobe. The preoperative serum KL-6 level was elevated to 8204 U/ml. We performed a four-port thoracoscopic basal segmentectomy and lymph node sampling for diagnosis and therapy. The postoperative diagnosis showed PSH. The serum KL-6 level decreased dramatically with tumour resection. To the best of our knowledge, this is the first report of a patient with PSH showing a high serum KL-6 level.
authors.affiliation: Division of Thoracic Surgical Oncology, Japanese Foundation for Cancer Research, Cancer Institute Hospital, Tokyo, Japan. kuroda_kn_hiroaki@ybb.ne.jp
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kuroda
authors.forename: Mingyon
authors.initials: M
authors.lastname: Mun
authors.forename: Sakae
authors.initials: S
authors.lastname: Okumura
authors.forename: Ken
authors.initials: K
authors.lastname: Nakagawa
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D018396:Mucin-1 / Q000097:blood*; D011013:Pneumonectomy / Q000379:methods*; D047868:Pulmonary Sclerosing Hemangioma / Q000097:blood / Q000175:diagnosis / Q000276:immunology / Q000601:surgery*; D003074:Solitary Pulmonary Nodule / Q000097:blood / Q000175:diagnosis / Q000276:immunology / Q000601:surgery*; D013906:Thoracoscopy; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D015854:Up-Regulation
chemical_list: D014408:Biomarkers, Tumor; C060192:MUC1 protein, human; D018396:Mucin-1