title: Specific expression of Kcna10, Pxn and Odf2 in the organ of Corti.
abstract: The development of the organ of Corti and the highly specialized cells required for hearing involves a multitude of genes, many of which remain unknown. Here we describe the expression pattern of three genes not previously studied in the inner ear in mice at a range of ages both embryonic and early postnatal. Kcna10, a tetrameric Shaker-like potassium channel, is expressed strongly in the hair cells themselves. Odf2, as its centriolar isoform Cenexin, marks the dendrites extending to and contacting hair cells, and Pxn, a focal adhesion scaffold protein, is most strongly expressed in pillar cells during the ages studied. The roles of these genes are yet to be elucidated, but their specific expression patterns imply potential functional significance in the inner ear.
authors.affiliation: Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
authors.forename: Francesca A
authors.initials: FA
authors.lastname: Carlisle
authors.forename: Karen P
authors.initials: KP
authors.lastname: Steel
authors.forename: Morag A
authors.initials: MA
authors.lastname: Lewis
mesh_terms: D000818:Animals; D020869:Gene Expression Profiling; D006309:Hearing; D006360:Heat-Shock Proteins / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009925:Organ of Corti / Q000378:metabolism*; D051419:Paxillin / Q000235:genetics / Q000378:metabolism*; D051637:Shaker Superfamily of Potassium Channels / Q000235:genetics / Q000378:metabolism*
chemical_list: D006360:Heat-Shock Proteins; C574338:KCNA10 protein, mouse; C490106:Odf2 protein, mouse; D051419:Paxillin; C496062:Pxn protein, mouse; D051637:Shaker Superfamily of Potassium Channels