title: Cyclooxygenase inhibitory properties of nor-neolignans from Styrax pohlii.
abstract: Chemical investigation of the n-hexane and EtOAc fractions of the ethanolic extract from Styrax pohlii (Styracaceae) aerial parts resulted in the isolation of the benzofuran nor-neolignan derivatives egonol (1), homoegonol (2), homoegonol gentiobioside (3), homoegonol glucoside (4) and egonol gentiobioside (5). This is the first report of compounds 1-5 in S. pohlii. Compounds 1-5, the acetyl derivatives 1 a and 2 a, the ethanolic extract (EE), the n-hexane fraction (HF) and EtOAc fraction (EF) were tested for their inhibitory activities against COX-1 and COX-2. The results showed that EE, HF, EF and compounds 1-5 and 1 a-2 a shown weak to moderate inhibition of COX-1 and COX-2. Among the assayed nor-neolignans, 4 gave a COX-1 inhibition of 35.7% at 30 µM. Compound 5 displayed a COX-2 inhibition of 19.7% at 30 µM.
authors.affiliation: Núcleo de Pesquisa em Ciências Exatas e Tecnológicas, Universidade de Franca, Franca, Brazil.
authors.forename: Camila S
authors.initials: CS
authors.lastname: Bertanha
authors.forename: Caio G
authors.initials: CG
authors.lastname: Braguine
authors.forename: Ana C G
authors.initials: AC
authors.lastname: Moraes
authors.forename: Valéria M M
authors.initials: VM
authors.lastname: Gimenez
authors.forename: Milton
authors.initials: M
authors.lastname: Groppo
authors.forename: Márcio L A
authors.initials: ML
authors.lastname: Silva
authors.forename: Wilson R
authors.initials: WR
authors.lastname: Cunha
authors.forename: Ana H
authors.initials: AH
authors.lastname: Januário
authors.forename: Patrícia M
authors.initials: PM
authors.lastname: Pauletti
mesh_terms: D001572:Benzofurans / Q000302:isolation & purification / Q000494:pharmacology; D001938:Brazil; D016861:Cyclooxygenase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004187:Disaccharides / Q000302:isolation & purification / Q000494:pharmacology; D000431:Ethanol; D005960:Glucosides / Q000302:isolation & purification / Q000494:pharmacology; D006586:Hexanes; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D032362:Styrax / Q000737:chemistry*
chemical_list: D001572:Benzofurans; D016861:Cyclooxygenase Inhibitors; D004187:Disaccharides; D005960:Glucosides; D006586:Hexanes; D017705:Lignans; D010936:Plant Extracts; C576931:egonol gentiobioside; C026385:n-hexane; D000431:Ethanol