title: Highly relaxing gadolinium based MRI contrast agents responsive to Mg2+ sensing.
abstract: A Gd complex based on a polyphosphonated pyridyl ligand shows a very high stability in aqueous solution (log K(EuL) = 25.7), a high relaxivity (8.5 mM(-1) s(-1) at 25 °C and 20 MHz) and a marked and selective relaxivity enhancement (37%) in the presence of Mg(2+), opening interesting perspectives for the design of cation responsive contrast agents.
authors.affiliation: Laboratoire d'Ingénierie Moléculaire Appliquée à l'Analyse, IPHC, UMR 7178 CNRS/UdS, ECPM 25 rue Becquerel, 67087 Strasbourg Cedex 2, France.
authors.forename: Sabah
authors.initials: S
authors.lastname: Abada
authors.forename: Alexandre
authors.initials: A
authors.lastname: Lecointre
authors.forename: Mourad
authors.initials: M
authors.lastname: Elhabiri
authors.forename: David
authors.initials: D
authors.lastname: Esteban-Gómez
authors.forename: Carlos
authors.initials: C
authors.lastname: Platas-Iglesias
authors.forename: Gaylord
authors.initials: G
authors.lastname: Tallec
authors.forename: Marinella
authors.initials: M
authors.lastname: Mazzanti
authors.forename: Loïc J
authors.initials: LJ
authors.lastname: Charbonnière
mesh_terms: D003287:Contrast Media / Q000737:chemistry*; D056831:Coordination Complexes / Q000737:chemistry; D005682:Gadolinium / Q000737:chemistry*; D008024:Ligands; D008274:Magnesium / Q000032:analysis*; D008279:Magnetic Resonance Imaging; D008958:Models, Molecular; D011725:Pyridines / Q000737:chemistry
chemical_list: D003287:Contrast Media; D056831:Coordination Complexes; D008024:Ligands; D011725:Pyridines; D005682:Gadolinium; D008274:Magnesium; C023666:pyridine