title: Matrix metalloproteinases 2, 7, and 9 in tumors and sera of patients with breast cancer.
abstract: Enzyme immunoassay showed that the content of matrix metalloproteinases (MMP) 2 and 7 in tumors was higher than in the adjacent histologically intact tissue in 91 and 76% patients with breast cancer, respectively, while MMP-9 levels in the tumor and intact tissue were virtually the same. Serum concentrations of MMP-2 and MMP-7 did not correlate with their levels in the tumors, were within the normal range, and virtually did not decrease after removal of the primary tumor. Serum levels of MMP-9 in patients were significantly lower than in the control and increased after surgery in 85% patients. No clear-cut relationship between the studied parameters and clinical morphological prognostic factors of breast cancer was detected.
authors.affiliation: N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: A I
authors.initials: AI
authors.lastname: Katunina
authors.forename: E S
authors.initials: ES
authors.lastname: Gershtein
authors.forename: V D
authors.initials: VD
authors.lastname: Ermilova
authors.forename: I V
authors.initials: IV
authors.lastname: Tereshkina
authors.forename: A Yu
authors.initials: AY
authors.lastname: Nazarenko
authors.forename: A A
authors.initials: AA
authors.lastname: Tyleuova
authors.forename: E K
authors.initials: EK
authors.lastname: Dvorova
authors.forename: Z K
authors.initials: ZK
authors.lastname: Karabekova
authors.forename: M V
authors.initials: MV
authors.lastname: Gritskevich
authors.forename: T T
authors.initials: TT
authors.lastname: Berezov
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000097:blood / Q000201:enzymology*; D005260:Female; D006801:Humans; D020778:Matrix Metalloproteinase 2 / Q000097:blood / Q000378:metabolism*; D020783:Matrix Metalloproteinase 7 / Q000097:blood / Q000378:metabolism*; D020780:Matrix Metalloproteinase 9 / Q000097:blood / Q000378:metabolism*; D008875:Middle Aged
chemical_list: D020783:Matrix Metalloproteinase 7; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9