title: [Effects of organic selenium supplement on glutathione peroxidase activities: a meta-analysis of randomized controlled trials].
abstract: OBJECTIVE
  To study the effects of organic selenium supplementation on glutathione peroxidase (GPx) activities.
  
  
  METHODS
  Randomized controlled trials (RCT) published from January 1988 to December 2010 on the relationship between organic selenium supplementation and GPx activities were collected. Meta-analysis was applied to estimate the combined standardized mean difference (SMD) and 95% confidence interval (95% CI).
  
  
  RESULTS
  A total of 10 RCTs were included. The number of studies observing GPx activities in plasma, erythrocyte and platelet was 8, 5 and 5, respectively. Compared with the controls, the combined SMD (95% CI) of GPx activities in plasma, erythrocyte and platelet of subjects supplemented with organic selenium was 0.46 (0.09 - 0.83), 0.36 (0.02 - 0.69) and 0.56 (-0.02 - 1.15).
  
  
  CONCLUSIONS
  Supplementation with organic selenium increases GPx activities in healthy adults.
authors.affiliation: Department of Nutrition and Food Hygiene, School of Radiation Medicine and Public Health, Soochow University, Suzhou 215123, China. whojx@126.com
authors.forename: Xia
authors.initials: X
authors.lastname: Jiang
authors.forename: Jiayi
authors.initials: J
authors.lastname: Dong
authors.forename: Bo
authors.initials: B
authors.lastname: Wang
authors.forename: Xuebin
authors.initials: X
authors.lastname: Yin
authors.forename: Liqiang
authors.initials: L
authors.lastname: Qin
mesh_terms: D019587:Dietary Supplements; D005979:Glutathione Peroxidase / Q000097:blood / Q000378:metabolism*; D006801:Humans; D009930:Organic Chemicals / Q000008:administration & dosage; D016032:Randomized Controlled Trials as Topic; D012643:Selenium / Q000008:administration & dosage*
chemical_list: D009930:Organic Chemicals; D005979:Glutathione Peroxidase; D012643:Selenium