title: Efficacy of Rhipicephalus (Boophilus) microplus Bm86 against Hyalomma dromedarii and Amblyomma cajennense tick infestations in camels and cattle.
abstract: The recombinant Bm86-based tick vaccines have shown their efficacy for the control of cattle ticks, Rhipicephalus (Boophilus) microplus and R. annulatus infestations. However, cattle ticks often co-exist with multi-host ticks such as Hyalomma and Amblyomma species, thus requiring the control of multiple tick infestations for cattle and other hosts. Vaccination trials using a R. microplus recombinant Bm86-based vaccine were conducted in cattle and camels against Hyalomma dromedarii and in cattle against Amblyomma cajennense immature and adult ticks. The results showed an 89% reduction in the number of H. dromedarii nymphs engorging on vaccinated cattle, and a further 32% reduction in the weight of the surviving adult ticks. In vaccinated camels, a reduction of 27% and 31% of tick engorgement and egg mass weight, respectively was shown, while egg hatching was reduced by 39%. However, cattle vaccination with Bm86 did not have an effect on A. cajennense tick infestations. These results showed that Bm86 vaccines are effective against R. microplus and other tick species but improved vaccines containing new antigens are required to control multiple tick infestations.
authors.affiliation: Centro de Ingenieria Genetic and Biotecnologia, Habana, Cuba. m.rodriguezvalle@uq.edu.au
authors.forename: Manuel
authors.initials: M
authors.lastname: Rodríguez-Valle
authors.forename: Amar
authors.initials: A
authors.lastname: Taoufik
authors.forename: Mario
authors.initials: M
authors.lastname: Valdés
authors.forename: Carlos
authors.initials: C
authors.lastname: Montero
authors.forename: Hassan
authors.initials: H
authors.lastname: Ibrahin
authors.forename: Shawgi Mohammed
authors.initials: SM
authors.lastname: Hassan
authors.forename: Frans
authors.initials: F
authors.lastname: Jongejan
authors.forename: Jose
authors.initials: J
authors.lastname: de la Fuente
mesh_terms: D000818:Animals; D002162:Camelus; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology / Q000517:prevention & control*; D005260:Female; D026863:Ixodidae / Q000276:immunology* / Q000472:pathogenicity*; D008297:Male; D008562:Membrane Glycoproteins / Q000008:administration & dosage / Q000276:immunology*; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000276:immunology*; D013984:Tick Infestations / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D014612:Vaccines / Q000008:administration & dosage / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000008:administration & dosage / Q000276:immunology
chemical_list: C085065:BM86 protein, Boophilus; D008562:Membrane Glycoproteins; D011994:Recombinant Proteins; D014612:Vaccines; D014614:Vaccines, Synthetic