title: A role for the NLRP3 inflammasome in metabolic diseases--did Warburg miss inflammation?
abstract: The inflammasome is a protein complex that comprises an intracellular sensor (typically a Nod-like receptor), the precursor procaspase-1 and the adaptor ASC. Inflammasome activation leads to the maturation of caspase-1 and the processing of its substrates, interleukin 1β (IL-1β) and IL-18. Although initially the inflammasome was described as a complex that affects infection and inflammation, subsequent evidence has suggested that inflammasome activation influences many metabolic disorders, including atherosclerosis, type 2 diabetes, gout and obesity. Another feature of inflammation in general and the inflammasome specifically is that the activation process has a profound effect on aerobic glycolysis (the 'Warburg effect'). Here we explore how the Warburg effect might be linked to inflammation and inflammasome activation.
authors.affiliation: Department of Microbiology and Immunology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
authors.forename: Haitao
authors.initials: H
authors.lastname: Wen
authors.forename: Jenny P-Y
authors.initials: JP
authors.lastname: Ting
authors.forename: Luke A J
authors.initials: LA
authors.lastname: O'Neill
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000276:immunology / Q000378:metabolism; D006019:Glycolysis / Q000276:immunology*; D006801:Humans; D058847:Inflammasomes / Q000276:immunology* / Q000378:metabolism*; D008659:Metabolic Diseases / Q000276:immunology* / Q000378:metabolism*; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein
chemical_list: D002352:Carrier Proteins; D058847:Inflammasomes; D000071199:NLR Family, Pyrin Domain-Containing 3 Protein; C453881:NLRP3 protein, human