title: B cells in allergic diseases: bad or better?
abstract: IgE-producing B cells are always considered as 'bad' guys in allergic diseases, as they play a direct role in promoting inflammatory responses against inhaled or ingested allergens and contribute to the development of subsequent clinical symptoms. During the past decade, mouse studies have shown that B cells may also have a 'better' side, producing IL-10 and suppressing inflammatory responses; those cells are called regulatory B (Breg) cells. There is evidence now that impairment of Breg cell activity may play a role in the development of inflammatory diseases. New transgenic models and renewed interest have expanded our knowledge on different B cell phenotypes, signals to promote their activity and their function in health and disease. This review will highlight the current knowledge on disease-promoting or disease-protecting activities of B cells and discuss its potential for therapeutic applications in allergies.
authors.affiliation: Department of Parasitology, Leiden University Medical Center, Leiden, The Netherlands. h.h.smits@lumc.nl
authors.forename: Hermelijn H
authors.initials: HH
authors.lastname: Smits
mesh_terms: D000818:Animals; D015551:Autoimmunity; D016175:B-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism; D001402:B-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D060151:B-Lymphocytes, Regulatory / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology* / Q000378:metabolism / Q000628:therapy; D008213:Lymphocyte Activation / Q000276:immunology