title: Screening for metabolic liver diseases crucial to increase SVR to patients with CHC.
abstract: Liver diseases and its complications is common health problem worldwide. The emergence of metabolic disorders as a cause after exclusion of viral hepatitis nowadays is important. This is retrospective study on 200 patient's age range from 6months to 18 years old (50 females and 150 males). The patients divided into 2 groups according to age < 5 years & >5 years and all investigations done was collected and statistically processed. Abdominal enlargement was observed in 166/200 of all patients, 48/166 (67.6%) in patients <5 years old and 118/166 (91.5%) in patients >5 years old with statistical significant, jaundice was present in 34/200 of patients, 23/34 (32.4%) in patients <5 years old and 11/34(8.5%) in patients >5 years old, with statistical significant difference, CBC was normal in 58/200 of all age groups. 10/58 (14.1%) in patients <5 years old, 48/58 (73.2%) in patients <5 years old, with statistical significant difference and abnormal CBC in 142/200 (61/142, 62.8%) in age group > 5 years old, 81/142 (85.9%) in age group <5 years. Metabolic disorders was normal in 124/200 of all age groups, 23/124 (32.4%) in patients <5 years old. Metabolic disorders was abnormal in 76/200 of all, 48/76(67.6%) in patients >5 years old and 28/76 (21.7%) in patients < 5 years old, with statistical significant difference & for both age groups. The sensitivity of modalities used in the diagnosis of liver disease was as follow for US, study of metabolic profile, abnormal liver functions and abnormal CBC, 83.1%, 65.2%, 61.6% and 66.1% consequently.
authors.affiliation: Department of Hepatology, Gastroenterology and infectious diseases, Faculty of Medicine, Benha University, Cairo, Egypt.
authors.forename: Reda M
authors.initials: RM
authors.lastname: El Badawy
authors.forename: Manal
authors.initials: M
authors.lastname: El Defrawy
authors.forename: Ahmed
authors.initials: A
authors.lastname: Elhenawy
authors.forename: Mahmoud M
authors.initials: MM
authors.lastname: Morsy
authors.forename: Ibrahim Ghoneam
authors.initials: IG
authors.lastname: Ramadan
mesh_terms: D000293:Adolescent; D000998:Antiviral Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D008297:Male; D008659:Metabolic Diseases / Q000175:diagnosis / Q000473:pathology*; D012189:Retrospective Studies
chemical_list: D000998:Antiviral Agents