title: Accelerating the multifunctionalization of therapeutic nanoparticles by using a multicomponent reaction.
abstract: Simpler and faster! Multifunctionalized nanoparticles are crucial for nanobiomedical applications, but their syntheses are tedious and time-consuming. A multicomponent reaction on nanostructures is an excellent way to prepare such nanomaterials. The gold nanosystem illustrated in the scheme was built and shown to enhance cancer cell targeting and killing by combining the effects of a therapeutic drug with X-ray radiation.
authors.affiliation: Department of Chemical Biology and Therapeutics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
authors.forename: Hongyu
authors.initials: H
authors.lastname: Zhou
authors.forename: Gaoxing
authors.initials: G
authors.lastname: Su
authors.forename: Peifu
authors.initials: P
authors.lastname: Jiao
authors.forename: Bing
authors.initials: B
authors.lastname: Yan
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D004317:Doxorubicin / Q000008:administration & dosage* / Q000494:pharmacology; D016503:Drug Delivery Systems / Q000379:methods*; D006046:Gold / Q000737:chemistry* / Q000627:therapeutic use; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D036103:Nanotechnology / Q000379:methods*; D009369:Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D014965:X-Rays
chemical_list: D000970:Antineoplastic Agents; D006046:Gold; D004317:Doxorubicin