title: The effects of liver transplantation on the clinical course of colitis in ulcerative colitis patients with primary sclerosing cholangitis.
abstract: BACKGROUND
  The course of ulcerative colitis (UC) following orthotopic liver transplantation (OLT) for primary sclerosing cholangitis (PSC) is unclear.
  
  
  OBJECTIVE
  To investigate the clinical course of UC, before and after OLT for PSC.
  
  
  METHODS
  From a historical cohort of 86 patients with PSC-UC who underwent OLT, 77 patients who were followed up at our institution both before and after OLT from 1985 to 2011 were included.
  
  
  RESULTS
  Ulcerative colitis was diagnosed in 77 (97.5%) patients before OLT. Nineteen of 77 (24.7%) patients underwent colectomy before OLT. In the other 58 patients, the course of UC after OLT when compared to the last 5 years before OLT was quiescent in 48 patients (82.8%) while 9/58 (15.5%) of patients underwent colectomy post-OLT. There was a total of 97 colitis flares over a total of 621 years of follow-up from PSC/UC diagnosis to OLT (0.156 flares per patient year) whereas post-OLT, there were 31 flares over a total of 511 years of post-OLT follow-up (0.061 flares per patient year) (P < 0.001). On univariable analysis, the number of UC flares [Odds ratio (OR) 1.52; 95% Confidence interval (1.02-2.27), P = 0.04] and dysplasia [OR 47.00; 95% CI (6.48-340.66), P < 0.001] increased the risk of colectomy following OLT; the use of corticosteroids [OR 0.07; 95% CI (0.01-0.63), P = 0.008] and 5-aminosalicylate [OR 0.18; 95% CI (0.04-0.83), P = 0.04] was protective.
  
  
  CONCLUSIONS
  Ulcerative colitis in the presence of primary sclerosing cholangitis remains quiescent, and may improve in most patients after orthotopic liver transplantation.
authors.affiliation: Department of Gastroenterology, Digestive disease Institute, The Cleveland Clinic, Cleveland, OH, USA.
authors.forename: U
authors.initials: U
authors.lastname: Navaneethan
authors.forename: M
authors.initials: M
authors.lastname: Choudhary
authors.forename: P G K
authors.initials: PG
authors.lastname: Venkatesh
authors.forename: B A
authors.initials: BA
authors.lastname: Lashner
authors.forename: F H
authors.initials: FH
authors.lastname: Remzi
authors.forename: B
authors.initials: B
authors.lastname: Shen
authors.forename: R P
authors.initials: RP
authors.lastname: Kiran
mesh_terms: D000328:Adult; D000368:Aged; D015209:Cholangitis, Sclerosing / Q000503:physiopathology* / Q000601:surgery; D015331:Cohort Studies; D003082:Colectomy / Q000379:methods; D003093:Colitis, Ulcerative / Q000150:complications / Q000503:physiopathology* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D016031:Liver Transplantation / Q000379:methods*; D008297:Male; D019804:Mesalamine / Q000627:therapeutic use; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D005938:Glucocorticoids; D019804:Mesalamine