title: A highly sensitive two-photon fluorescent probe for mitochondrial zinc ions in living tissue.
abstract: We report a highly sensitive two-photon probe (SZn2-Mito) which shows a 70-fold two-photon excited fluorescence enhancement in response to Zn(2+) and can selectively detect mitochondrial Zn(2+) in a rat hippocampal slice at a depth of 100-200 μm by using two-photon microscopy.
authors.affiliation: Division of Energy Systems Research and Molecular Science & Technology Research Center, Ajou University, Suwon, 443-749, Korea.
authors.forename: Na Young
authors.initials: NY
authors.lastname: Baek
authors.forename: Cheol Ho
authors.initials: CH
authors.lastname: Heo
authors.forename: Chang Su
authors.initials: CS
authors.lastname: Lim
authors.forename: Goutam
authors.initials: G
authors.lastname: Masanta
authors.forename: Bong Rae
authors.initials: BR
authors.lastname: Cho
authors.forename: Hwan Myung
authors.initials: HM
authors.lastname: Kim
mesh_terms: D000818:Animals; D005456:Fluorescent Dyes / Q000737:chemistry*; D006367:HeLa Cells; D006624:Hippocampus / Q000378:metabolism; D006801:Humans; D007259:Infrared Rays; D007477:Ions / Q000737:chemistry; D008856:Microscopy, Fluorescence; D008928:Mitochondria / Q000378:metabolism*; D017785:Photons; D051381:Rats; D015032:Zinc / Q000032:analysis*
chemical_list: D005456:Fluorescent Dyes; D007477:Ions; D015032:Zinc