title: The biosynthetic products of Chinese insect medicine, Aspongopus chinensis.
abstract: A new oxazole (1) was obtained from Chinese insect medicine Aspongopus chinensis, along with three known N-acetyldopamine derivatives (2-4). Their structures were determined on the basis of NMR and ESI-MS analyses. The possible biosynthetic pathways of the isolated compounds are discussed. Cytotoxicities of those compounds against 10 selected cancer cells were measured in vitro.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, PR China.
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Luo
authors.forename: Xiao-Zheng
authors.initials: XZ
authors.lastname: Wang
authors.forename: Hai-Long
authors.initials: HL
authors.lastname: Jiang
authors.forename: Jun-Li
authors.initials: JL
authors.lastname: Yang
authors.forename: Phillip
authors.initials: P
authors.lastname: Crews
authors.forename: Frederick A
authors.initials: FA
authors.lastname: Valeriote
authors.forename: Quan-Xiang
authors.initials: QX
authors.lastname: Wu
mesh_terms: D000818:Animals; D001688:Biological Products / Q000737:chemistry* / Q000494:pharmacology; D053898:Biosynthetic Pathways; D045744:Cell Line, Tumor; D004298:Dopamine / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology; D006430:Hemiptera / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D009369:Neoplasms / Q000188:drug therapy; D010080:Oxazoles / Q000302:isolation & purification* / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D001688:Biological Products; D010080:Oxazoles; C006374:N-acetyldopamine; D004298:Dopamine