title: Relationship between the expression of VEGF signal components and matrix metalloproteinases in ovarian tumors.
abstract: The content of vascular endothelium growth factor is significantly increased, while the level of matrix metalloproteinase-2 is 2-fold reduced in ovarian cancer tissue compared to benign tumors. A trend to an increase in the levels of matrix metalloproteinases 7 and 9 and reduction of vascular endothelial growth factor type 2 receptors in tumor tissue was also detected. A highly significant negative correlation between the levels of vascular endothelial growth factor and matrix metalloproteinase 2 and positive correlations between vascular endothelial growth factor and matrix metalloproteinase 7, vascular endothelial growth factor and matrix metalloproteinase 9, matrix metalloproteinase 2 and vascular endothelial growth factor type 2 receptors were revealed. In the tumors assayed after preoperative therapy, relative normalization of the studied parameters was observed: the level of vascular endothelial growth factor decreased significantly, while the levels of matrix metalloproteinase 2 and vascular endothelial growth factor type 2 receptors increased. The levels of the markers differed significantly in ovarian tumors of different histological types, and the levels of vascular endothelial growth factor type 2 receptors were higher in patients with stage III compared to stage I and the content of matrix metalloproteinase 7 was higher in stage III compared to stage II cancer.
authors.affiliation: N. N. Blokhin Russian Cancer Research Center, Russian Academy of Medical Sciences, Moscow, Russia. esgershtein@gmail.com
authors.forename: E S
authors.initials: ES
authors.lastname: Gershtein
authors.forename: D N
authors.initials: DN
authors.lastname: Kushlinsky
authors.forename: N V
authors.initials: NV
authors.lastname: Levkina
authors.forename: I V
authors.initials: IV
authors.lastname: Tereshkina
authors.forename: V B
authors.initials: VB
authors.lastname: Nosov
authors.forename: K P
authors.initials: KP
authors.lastname: Laktionov
authors.forename: L V
authors.initials: LV
authors.lastname: Adamyan
mesh_terms: D005260:Female; D006801:Humans; D020782:Matrix Metalloproteinases / Q000378:metabolism*; D010051:Ovarian Neoplasms / Q000201:enzymology*; D015398:Signal Transduction; D042461:Vascular Endothelial Growth Factor A / Q000378:metabolism*
chemical_list: D042461:Vascular Endothelial Growth Factor A; D020782:Matrix Metalloproteinases