title: Bioactive diterpenes from Callicarpa longissima.
abstract: Investigation of the leaves and twigs of Callicarpa longissima resulted in the isolation of four new compounds (1-4), callilongisins A-D, and five known compounds, ursolic acid, 3-oxoanticopalic acid, (E)-6β-hydroxylabda-8(17),13-dien-15-oic acid, 5-hydroxy-3,6,7,4'-tetramethoxyflavone, and artemetin. Compounds 1-3 are 3,4-seco-abietane-type diterpenoids, and compound 4 is an analogue of a labdenoic-type diterpene. The structure of compound 1 was confirmed by X-ray crystallographic analysis. Cytotoxicity against a human prostate cancer cell line (PC3) and anti-inflammatory activities of the isolated compounds were evaluated.
authors.affiliation: School of Pharmacy, College of Medicine, National Taiwan University, Jen-Ai Road, Section 1, Taipei 100, Taiwan.
authors.forename: Yuan-Wei
authors.initials: YW
authors.lastname: Liu
authors.forename: Yuan-Bin
authors.initials: YB
authors.lastname: Cheng
authors.forename: Chia-Ching
authors.initials: CC
authors.lastname: Liaw
authors.forename: Chung-Hsiung
authors.initials: CH
authors.lastname: Chen
authors.forename: Jih-Hwa
authors.initials: JH
authors.lastname: Guh
authors.forename: Tsong-Long
authors.initials: TL
authors.lastname: Hwang
authors.forename: Ji-Shu
authors.initials: JS
authors.lastname: Tsai
authors.forename: Won-Bo
authors.initials: WB
authors.lastname: Wang
authors.forename: Ya-Ching
authors.initials: YC
authors.lastname: Shen
mesh_terms: D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D032408:Callicarpa / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008297:Male; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018515:Plant Leaves / Q000737:chemistry
chemical_list: D000893:Anti-Inflammatory Agents; D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes