title: [Study on the inhibitory effect of cepharanthine on herpes simplex type-1 virus (HSV-1) in vitro].
abstract: OBJECTIVE
  To assay the inhibitory effects of cepharanthine on HSV-1 in vitro.
  
  
  METHODS
  Vero cells were infected by HSV-1 and cultured with serial dilutions of cepharanthine. The inhibitory effects of cepharanthine were evaluated with cytopathogenic effects (CPE).
  
  
  RESULTS
  The CPE of cells infected by HSV-1 were inhibited significantly, resulting in higher cell survival rates.
  
  
  CONCLUSIONS
  The results showed that cepharanthine had obvious HSV-1 inhibitory efficacy. Therefore, it may become a potential candidate in drug development and deserves further research on animal experiment and antiviral mechanisms.
authors.affiliation: Jinan University, Guangzhou 510632.
authors.forename: Xinjian
authors.initials: X
authors.lastname: Liu
authors.forename: Yifei
authors.initials: Y
authors.lastname: Wang
authors.forename: Meiying
authors.initials: M
authors.lastname: Zhang
authors.forename: Guisheng
authors.initials: G
authors.lastname: Li
authors.forename: Yingzhou
authors.initials: Y
authors.lastname: Cen
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage / Q000494:pharmacology*; D044182:Benzylisoquinolines / Q000008:administration & dosage / Q000494:pharmacology*; D002470:Cell Survival; D002522:Chlorocebus aethiops; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D006566:Herpesviridae Infections / Q000517:prevention & control; D018259:Herpesvirus 1, Human / Q000187:drug effects* / Q000502:physiology; D020128:Inhibitory Concentration 50; D031607:Stephania / Q000737:chemistry*; D014709:Vero Cells; D014779:Virus Replication / Q000187:drug effects; D052117:Benzodioxoles
chemical_list: D000998:Antiviral Agents; D044182:Benzylisoquinolines; C006947:cepharanthine; D052117:Benzodioxoles