title: Identification of a macro-alkaline phosphatase complex in a patient with inflammatory bowel disease.
abstract: We report the rare finding of a macro-alkaline phosphatase (macroALP) complex in a patient with a previously unexplained raised alkaline phosphatase activity. The clinical symptoms were persistent, daily diarrhoea for two months with blood in the stool. The patient was subsequently diagnosed with inflammatory bowel disease, specifically ulcerative colitis, following a rectal biopsy and colonoscopy. Two cases of macroALP associated with ulcerative colitis have been reported before, suggesting there could be an increased prevalence of macroALP in these patients.
authors.affiliation: Department of Clinical Biochemistry, East Kent Hospitals University NHS Foundation Trust, Canterbury, Kent CT1 3NG, UK. m.mctaggart@nhs.net
authors.forename: Malcolm P
authors.initials: MP
authors.lastname: McTaggart
authors.forename: Catherine
authors.initials: C
authors.lastname: Rawson
authors.forename: David
authors.initials: D
authors.lastname: Lawrence
authors.forename: Barbara S
authors.initials: BS
authors.lastname: Raney
authors.forename: Linnet
authors.initials: L
authors.lastname: Jaundrill
authors.forename: Lorna A
authors.initials: LA
authors.lastname: Miller
authors.forename: Joseph
authors.initials: J
authors.lastname: Murtinho-Braga
authors.forename: Edward M
authors.initials: EM
authors.lastname: Kearney
mesh_terms: D000328:Adult; D000469:Alkaline Phosphatase / Q000378:metabolism*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000201:enzymology*; D008297:Male
chemical_list: D000469:Alkaline Phosphatase