title: The role of micro-RNAs in the female reproductive tract.
abstract: Proper development and function of the female reproductive tract are essential for successful reproduction. Regulation of the differentiated functions of the organs that make up the female reproductive tract is well established to occur at multiple levels including transcription, translation, and posttranslational modifications. Micro-RNA (miRNA)-mediated posttranscriptional gene regulation has emerged as a fundamental mechanism controlling normal tissue development and function. Emerging evidence indicates that miRNAs are expressed within the organs of the female reproductive tract where they function to regulate cellular pathways necessary for proper function of these organs. In this review, the functional significance of miRNAs in the development and function of the organs of the female reproductive tract is discussed. Initial discussion focuses on the role of miRNAs in the development of the organs of the female reproductive tract highlighting recent studies that clearly demonstrate that mice with disrupted Dicer1 expression are sterile, fail to develop uterine glands, and have muted estrogen responsiveness. Next, emphasis moves to discussion on our current knowledge on the characterization of miRNA expression in each of the organs of the female reproductive tract. When possible, information is presented and discussed with respect to regulation, function, and/or functional targets of these miRNA within each specific organ of the female reproductive tract.
authors.affiliation: Departments of Obstetrics and Gynecology and Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas 66160, USA. wnothnic@kumc.edu
authors.forename: Warren B
authors.initials: WB
authors.lastname: Nothnick
mesh_terms: D000818:Animals; D005187:Fallopian Tubes / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D005786:Gene Expression Regulation; D005836:Genitalia, Female / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D007247:Infertility, Female / Q000235:genetics* / Q000503:physiopathology; D035683:MicroRNAs / Q000378:metabolism*; D010053:Ovary / Q000378:metabolism / Q000503:physiopathology; D010057:Oviducts / Q000378:metabolism / Q000503:physiopathology; D012098:Reproduction / Q000235:genetics*; D043244:Ribonuclease III / Q000378:metabolism; D014599:Uterus / Q000378:metabolism / Q000503:physiopathology
chemical_list: D035683:MicroRNAs; D043244:Ribonuclease III