title: New encoded single-indicator sequences based on physico-chemical parameters for efficient exon identification.
abstract: The first step in gene identification problem based on genomic signal processing is to convert character strings into numerical sequences. These numerical sequences are then analysed spectrally or using digital filtering techniques for the period-3 peaks, which are present in exons (coding areas) and absent in introns (non-coding areas). In this paper, we have shown that single-indicator sequences can be generated by encoding schemes based on physico-chemical properties. Two new methods are proposed for generating single-indicator sequences based on hydration energy and dipole moments. The proposed methods produce high peak at exon locations and effectively suppress false exons (intron regions having greater peak than exon regions) resulting in high discriminating factor, sensitivity and specificity.
authors.affiliation: Department of Computer Science and Engineering, Vikash College of Engineering for Women, Vikash Enclave, Bargarh, Odisha, India. jk_meher@yahoo.co.in
authors.forename: J K
authors.initials: JK
authors.lastname: Meher
authors.forename: P K
authors.initials: PK
authors.lastname: Meher
authors.forename: G N
authors.initials: GN
authors.lastname: Dash
authors.forename: M K
authors.initials: MK
authors.lastname: Raval
mesh_terms: D001483:Base Sequence; D005091:Exons; D023281:Genomics / Q000379:methods*; D007438:Introns