title: Pharmacokinetic study of Noni fruit extract.
abstract: Many different products containing Noni (Morinda citrifolia) fruit extracts are sold throughout the world for health restoration and maintenance. Despite a large business enterprise fueling Noni's popularity, there is a lack of standardization of products and no scientific evidence of Noni's clinical efficacy and safety. There is also no evidence to indicate an optimal therapeutic dose or dosing interval. In an initial volunteer, scopoletin was identified as a bioactive marker of Noni exposure and a candidate for product standardization and pharmacokinetic studies. Subsequently, capsules containing the whole freeze-dried fruit of Noni were orally administered to nine healthy volunteers (3 per group) at doses of 1,500 mg (3 × 500 mg), 2,000 mg (4 × 500 mg) and 2,500 mg (5 × 500 mg). Plasma and urine samples were obtained from each subject prior to dosing and at 0.5, 1, 2, 4 and 8 h after dosing. Concentrations of scopoletin were determined by HPLC with PDA (scanning at 200-700 nm) and MS detection. Scopoletin rapidly enters the plasma after Noni ingestion, maintaining levels in the range of 0.5 to 5 ng/mL for at least 8 h after dosing. Scopoletin bioavailability appears to be low, with significant intersubject variability. We conclude that scopoletin can be used as a relatively specific marker of Noni exposure in the blood and particularly in urine when its pharmacokinetics is considered appropriately.
authors.affiliation: University of Hawaii's Cancer Research Center, HI, USA. issell.brian@scrippshealth.org
authors.forename: Brian F
authors.initials: BF
authors.lastname: Issell
authors.forename: Adrian
authors.initials: A
authors.lastname: Franke
authors.forename: Robert M
authors.initials: RM
authors.lastname: Fielding
mesh_terms: D000328:Adult; D001682:Biological Availability; D015415:Biomarkers / Q000097:blood / Q000652:urine; D002851:Chromatography, High Pressure Liquid; D005260:Female; D005612:Freeze Drying; D005638:Fruit / Q000737:chemistry*; D006801:Humans; D008297:Male; D008875:Middle Aged; D032066:Morinda / Q000737:chemistry*; D008517:Phytotherapy; D028321:Plant Preparations / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics* / Q000592:standards; D012015:Reference Standards; D012603:Scopoletin / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics* / Q000592:standards
chemical_list: D015415:Biomarkers; D028321:Plant Preparations; D012603:Scopoletin