title: Developing an anti-Campylobacter jejuni vaccine.
abstract: The proteomics era allows for the definition of biological organisms at the protein level, offering new opportunities for delimiting the self- and non-self boundaries between microbes and the human host. Here, we apply proteomics to design a vaccine against the major pathogenic factor of Campylobacter jejuni, i.e. cytolethal distending toxin (CDT). We used the scientific rationale that only peptide sequences not represented in the host proteome have the potential to evoke powerful, non-cross-reactive immune responses, thereby guaranteeing effectiveness and safety.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Bari, Italy. guglielmo.lucchese@gmail.com
authors.forename: G
authors.initials: G
authors.lastname: Lucchese
authors.forename: A Pesce
authors.initials: AP
authors.lastname: Delfino
mesh_terms: D001427:Bacterial Toxins / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D001428:Bacterial Vaccines / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D002169:Campylobacter Infections / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000517:prevention & control; D016123:Campylobacter jejuni / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D010455:Peptides / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D040901:Proteomics / Q000379:methods
chemical_list: D001427:Bacterial Toxins; D001428:Bacterial Vaccines; D010455:Peptides; C067044:cytolethal distending toxin