title: A case of anti-NMDAR (N-methyl-D-aspartate receptor) encephalitis: a rehabilitation perspective.
abstract: Anti-NMDAR (N-Methyl-D-Aspartate Receptor) Encephalitis is a rare occurring autoimmune disease that is mediated by antibodies against the NR1 subunit of the NMDA receptor. While this condition has a known predilection for young females with ovarian tumors, heightened awareness has led to increasing recognition of this condition in other population groups as well. Afflicted patients typically evolve through a multi-staged course of neurological, behavioral, cognitive and physical deficits. The diverse nature of this condition often necessitates a multi-disciplinary team for management. As the recovery of patients with anti-NMDAR encephalitis is often protracted, the role of the rehabilitation is important particularly beyond its acute stages. We describe a case of anti-NMDAR encephalitis in a 17-year-old girl who presented to our rehabilitation centre for management in the gradual recovery phase of her condition. This case illustrates the multiple challenges faced in the rehabilitation of such a patient.
authors.affiliation: Department of Rehabilitation Medicine, Tan Tock Seng Hospital, Singapore.
authors.forename: Shuen-Loong
authors.initials: SL
authors.lastname: Tham
authors.forename: Keng-He
authors.initials: KH
authors.lastname: Kong
mesh_terms: D000293:Adolescent; D001323:Autoantibodies / Q000096:biosynthesis / Q000097:blood*; D004569:Electroencephalography; D004660:Encephalitis / Q000097:blood* / Q000534:rehabilitation*; D005260:Female; D006801:Humans; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors* / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D016194:Receptors, N-Methyl-D-Aspartate