title: [Drug-induced liver injury].
abstract: Drug-induced liver injury represents the principal cause of acute liver failure and orthotopic liver transplantation in western country. A very large number of different drugs and medicinal herbs has been associated with liver injury but just for few of them we know the process that causes liver disease. All the people which ingest a large number of drugs present a risk of developing liver injury. Diagnosis is very difficult because a specific biomarker of damage is absent and the clinical picture is common to other liver diseases. A therapeutic approach is efficacy only in few cases. When a drug-induced liver injury is suspected, cessation of the drug is the first step in their management.
authors.affiliation: Dipartmento di Scienze Della Salute, Università Magna Græcia, Catanzaro. l.abenavoli@unicz.it
authors.forename: Ludovico
authors.initials: L
authors.lastname: Abenavoli
authors.forename: Emanuela
authors.initials: E
authors.lastname: Libri
authors.forename: Domenico
authors.initials: D
authors.lastname: Bosco
authors.forename: Dionisio
authors.initials: D
authors.lastname: Gallo
authors.forename: Francesco
authors.initials: F
authors.lastname: Luzza
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects*; D000465:Algorithms; D000658:Amoxicillin / Q000009:adverse effects; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects; D018685:Anesthetics, Inhalation / Q000009:adverse effects; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D000995:Antitubercular Agents / Q000009:adverse effects; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis; D006221:Halothane / Q000009:adverse effects; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects; D007538:Isoniazid / Q000009:adverse effects; D020901:Kava / Q000009:adverse effects; D017114:Liver Failure, Acute / Q000139:chemically induced* / Q000175:diagnosis; D012307:Risk Factors; D012720:Severity of Illness Index; D013449:Sulfonamides / Q000009:adverse effects
chemical_list: D018712:Analgesics, Non-Narcotic; D018685:Anesthetics, Inhalation; D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000995:Antitubercular Agents; D006993:Hypnotics and Sedatives; D013449:Sulfonamides; D000082:Acetaminophen; D000658:Amoxicillin; D006221:Halothane; C012655:nimesulide; D007538:Isoniazid