title: Where does a migraine attack originate? In the brainstem.
abstract: Migraine is a common, paroxysmal, highly disabling primary headache disorder. The origin of migraine attacks is enigmatic. Numerous clinical and experimental results suggest that the activation of distinct brainstem nuclei is crucial in its pathogenesis, but the primary cause of this activation is not fully understood. We conclude that the initialization of a migraine attack can be explained as an altered function of the neuronal elements of the brainstem nuclei. In light of our findings and the literature data, we can assume that migraine is a subcortical disorder of a specific brainstem area.
authors.affiliation: Department of Neurology, Albert Szent-Györgyi Clinical Centre, University of Szeged, Semmelweis u. 6, Szeged 6725, Hungary.
authors.forename: J
authors.initials: J
authors.lastname: Tajti
authors.forename: D
authors.initials: D
authors.lastname: Szok
authors.forename: Á
authors.initials: Á
authors.lastname: Párdutz
authors.forename: B
authors.initials: B
authors.lastname: Tuka
authors.forename: A
authors.initials: A
authors.lastname: Csáti
authors.forename: A
authors.initials: A
authors.lastname: Kuris
authors.forename: J
authors.initials: J
authors.lastname: Toldi
authors.forename: L
authors.initials: L
authors.lastname: Vécsei
mesh_terms: D000818:Animals; D001933:Brain Stem / Q000503:physiopathology*; D006801:Humans; D008881:Migraine Disorders / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D009434:Neural Pathways / Q000503:physiopathology