title: Gene classification using parameter-free semi-supervised manifold learning.
abstract: A new manifold learning method, called parameter-free semi-supervised local Fisher discriminant analysis (pSELF), is proposed to map the gene expression data into a low-dimensional space for tumor classification. Motivated by the fact that semi-supervised and parameter-free are two desirable and promising characteristics for dimension reduction, a new difference-based optimization objective function with unlabeled samples has been designed. The proposed method preserves the global structure of unlabeled samples in addition to separating labeled samples in different classes from each other. The semi-supervised method has an analytic form of the globally optimal solution, which can be computed efficiently by eigen decomposition. Experimental results on synthetic data and SRBCT, DLBCL, and Brain Tumor gene expression data sets demonstrate the effectiveness of the proposed method.
authors.affiliation: Key Laboratory on Opto-Electronic Technique and Systems, Ministry of Education, Chongqing University, Chongqing 400044, China. hhuang.cqu@gmail.com
authors.forename: Hong
authors.initials: H
authors.lastname: Huang
authors.forename: Hailiang
authors.initials: H
authors.lastname: Feng
mesh_terms: D000465:Algorithms; D015870:Gene Expression; D005796:Genes; D009369:Neoplasms / Q000145:classification / Q000235:genetics*; D010363:Pattern Recognition, Automated