title: Threefold exposure to moderate hypobaric hypoxia decreases the expression of Cu,Zn-superoxide dismutase in some regions of rat hippocampus.
abstract: The effect of moderate hypobaric hypoxia on the expression of a peptide antioxidant Cu,Zn-superoxide dismutase in rat hippocampal neurons was evaluated in an immunocytochemical study. The expression of Cu,Zn-superoxide dismutase decreased significantly in the dorsal hippocampus (CA1 and CA2) and tended to decrease in ventral regions (CA3 and dentate gyrus) by the 24th hour after 3-fold exposure to hypoxia.
authors.affiliation: Laboratory for Regulation of Brain Neuron Functions, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, Russia.
authors.forename: S A
authors.initials: SA
authors.lastname: Stroev
authors.forename: E I
authors.initials: EI
authors.lastname: Tyul'kova
authors.forename: M T
authors.initials: MT
authors.lastname: Pelto-Huikko
authors.forename: M O
authors.initials: MO
authors.lastname: Samoilov
mesh_terms: D000818:Animals; D056547:CA1 Region, Hippocampal / Q000201:enzymology; D056654:CA3 Region, Hippocampal / Q000201:enzymology; D018891:Dentate Gyrus / Q000201:enzymology; D006624:Hippocampus / Q000201:enzymology*; D000860:Hypoxia / Q000201:enzymology*; D008297:Male; D009474:Neurons / Q000201:enzymology*; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism*
chemical_list: D013482:Superoxide Dismutase