title: Topical 1% oxytetracycline hydrochloride versus placebo in oral mucosa biopsy.
abstract: BACKGROUND
  Oral surgical procedures produce side effects such as pain and inflammation, the magnitude of which depends on the degree of tissue damage produced.
  
  
  OBJECTIVE
  To explore the effectiveness and safety of the topical application of 1% oxytetracycline hydrochloride after biopsy of the oral mucosa.
  
  
  METHODS
  A randomized, double-blind, placebo- and no treatment-controlled study was conducted in 90 patients with lesions needing histopathologic analysis. The patients were divided into three groups. Group I (control) received no treatment; in group II, the site of surgical intervention was treated topically with 1% oxytetracycline hydrochloride three times a day for 1 week; and in group III, the patients were treated in the same way but with placebo. Using a visual analog scale, we determined the time of maximum postoperative pain.
  
  
  RESULTS
  Maximum pain intensity was recorded in the placebo group, with peak pain occurring 24 hours after surgery. The pain subsequently tended to decrease gradually over the 1-week period of the study. The maximum level of pain was significantly lower in group II than in the controls. No adverse effects were recorded.
  
  
  CONCLUSIONS
  Topical 1% oxytetracycline hydrochloride decreases pain symptoms after oral mucosa biopsy.
authors.affiliation: Department of Oral Medicine, Faculty of Medicine and Odontology, University of Murcia, Murcia, Spain. majornet@um.es
authors.forename: Pia
authors.initials: P
authors.lastname: López-Jornet
authors.forename: Fabio
authors.initials: F
authors.lastname: Camacho-Alonso
authors.forename: Ascensión
authors.initials: A
authors.lastname: Martinez-Canovas
authors.forename: Miriam
authors.initials: M
authors.lastname: Sidrach-Cardona
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001706:Biopsy / Q000009:adverse effects; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000473:pathology* / Q000601:surgery; D010118:Oxytetracycline / Q000627:therapeutic use*; D010149:Postoperative Pain / Q000209:etiology*; D018709:Statistics, Nonparametric; D013530:Surgical Wound Infection / Q000517:prevention & control; D013997:Time Factors; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D010118:Oxytetracycline