title: Genetic variant rs4982958 at 14q11.2 is associated with allergic rhinitis in a Chinese Han population running title: 14q11.2 is a susceptibility locus for allergic rhinitis.
abstract: BACKGROUND
  Allergic rhinitis (AR) is one of the most common diseases caused by the combined effects of intrinsic factors (susceptibility genes and immunological status) and the external environment. Analyses of ascendant family history of atopic disease suggest that AR and atopic dermatitis might share a similar genetic background.
  
  
  OBJECTIVE
  To conduct a case-control study in a Chinese Han population to evaluate the potential influence of single nucleotide polymorphisms (SNPs) at FLG, 5q22.1, 11q13.5, 14q11.2 and 20q13.33 on AR.
  
  
  METHODS
  Ten SNPs--rs11204971 and rs3126085 at FLG, rs10067777, rs7701890, rs13360927, and rs13361382 at 5q22.1, rs6010620 at 20q13.33, rs7936562 and rs7124842 at 11q13.5, and rs4982958 at 14q11.2 were genotyped in 363 cases and 668 controls using the Sequenom MassArray system. Data were analyzed with PLINK 1.07 software.
  
  
  RESULTS
  The T allele of rs4982958 at 14q11.2 was observed to be significantly associated with AR (P = .002, OR = 0.73, P(Bonferront) = .02). Genotype-based association testing revealed that the recessive model might provide the best fit for rs4982958 (P(Bonferroni) = .01). In subphenotype analyses, the rs4982958 T allele was also significantly associated with persistent AR (P = .01) and more than 2 positive skin prick tests (P = .038).
  
  
  CONCLUSIONS
  We identified a novel susceptibility locus 14q11.2 for AR that might bear candidate genes conferring susceptibility to AR and affecting disease phenotypes.
authors.affiliation: Institute of Dermatology, Department of Dermatology, No.1 Hospital, Anhui Medical University, Hefei, Anhui, China.
authors.forename: X F
authors.initials: XF
authors.lastname: Tang
authors.forename: H Y
authors.initials: HY
authors.lastname: Tang
authors.forename: L D
authors.initials: LD
authors.lastname: Sun
authors.forename: F L
authors.initials: FL
authors.lastname: Xiao
authors.forename: Z
authors.initials: Z
authors.lastname: Zhang
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.forename: X B
authors.initials: XB
authors.lastname: Zuo
authors.forename: F S
authors.initials: FS
authors.lastname: Zhou
authors.forename: K L
authors.initials: KL
authors.lastname: Yang
authors.forename: P
authors.initials: P
authors.lastname: Fang
authors.forename: Y H
authors.initials: YH
authors.lastname: Liu
authors.forename: W D
authors.initials: WD
authors.lastname: Du
authors.forename: S
authors.initials: S
authors.lastname: Yang
authors.forename: M L
authors.initials: ML
authors.lastname: Duan
authors.forename: X J
authors.initials: XJ
authors.lastname: Zhang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D001483:Base Sequence; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002681:China; D003876:Dermatitis, Atopic / Q000235:genetics* / Q000276:immunology; D005260:Female; D000091344:Filaggrin Proteins; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000235:genetics; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D006255:Rhinitis, Allergic, Seasonal / Q000208:ethnology / Q000235:genetics* / Q000276:immunology; D017422:Sequence Analysis, DNA; D012882:Skin Tests