title: Thyrotoxicosis.
abstract: Hyperthyroidism describes the sustained increase in thyroid hormone biosynthesis and secretion by a thyroid gland with increased metabolism. Although the use of radioiodine scanning serves as a useful surrogate that may help characterize the cause of thyrotoxicosis, it only indirectly addresses the underlying physiologic mechanism driving the increase in serum thyroid hormones. In this article, thyrotoxic states are divided into increased or decreased thyroid metabolic function. In addition to the diagnosis, clinical presentation, and treatment of the various causes of hyperthyroidism, a section on functional imaging and appropriate laboratory testing is included.
authors.affiliation: Division of Endocrinology and Metabolism, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.
authors.forename: Stuart C
authors.initials: SC
authors.lastname: Seigel
authors.forename: Steven P
authors.initials: SP
authors.lastname: Hodak
mesh_terms: D006801:Humans; D006980:Hyperthyroidism / Q000175:diagnosis / Q000628:therapy; D012307:Risk Factors; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000503:physiopathology*; D013971:Thyrotoxicosis / Q000175:diagnosis* / Q000628:therapy*; D013972:Thyrotropin / Q000378:metabolism
chemical_list: D013972:Thyrotropin