title: Association among retinol-binding protein 4, small dense LDL cholesterol and oxidized LDL levels in dyslipidemia subjects.
abstract: OBJECTIVE
  To investigate retinol-binding protein 4 (RBP4), small dense low-density lipoprotein cholesterol (sdLDL-C) and oxidized low-density lipoprotein (ox-LDL) levels and their associations in dyslipidemia subjects.
  
  
  METHODS
  We determined RBP4, sdLDL-C, ox-LDL levels in 150 various dyslipidemia subjects and 50 controls. The correlation analysis and multiple linear regression analysis were performed.
  
  
  RESULTS
  The RBP4, sdLDL-C and ox-LDL levels were found increased in various dyslipidemia subjects. The sdLDL-C levels were positively correlated with RBP4 (r=0.273, P=0.001) and ox-LDL (r=0.273, P=0.001). RBP4 levels were also correlated with ox-LDL (r=0.167, P=0.043). The multiple regression analysis showed that only sdLDL-C was a significant independent predictor for RBP4 (β coefficient=0.219, P=0.009; adjusted R(2)=0.041) and ox-LDL (β coefficient=0.253, P=0.003; adjusted R(2)=0.057) levels, respectively.
  
  
  CONCLUSIONS
  The independent associations of sdLDL-C with RBP4 and ox-LDL were observed in dyslipidemia subjects. RBP4 may play an important role in lipid metabolism of atherosclerosis, particularly in formation of sdLDL.
authors.affiliation: Department of Biochemistry, Jinling Hospital, Clinical School of Medicine, Nanjing University, 210002, Nanjing, PR China.
authors.forename: Jia
authors.initials: J
authors.lastname: Wu
authors.forename: Yong-hui
authors.initials: YH
authors.lastname: Shi
authors.forename: Dong-mei
authors.initials: DM
authors.lastname: Niu
authors.forename: Han-qing
authors.initials: HQ
authors.lastname: Li
authors.forename: Chun-ni
authors.initials: CN
authors.lastname: Zhang
authors.forename: Jun-jun
authors.initials: JJ
authors.lastname: Wang
mesh_terms: D000328:Adult; D050197:Atherosclerosis / Q000097:blood / Q000150:complications; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D008078:Cholesterol, LDL / Q000097:blood*; D050171:Dyslipidemias / Q000097:blood* / Q000150:complications; D006801:Humans; D050356:Lipid Metabolism; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012044:Regression Analysis; D054839:Retinol-Binding Proteins, Plasma / Q000032:analysis*; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D008078:Cholesterol, LDL; D008077:Lipoproteins, LDL; C101326:RBP4 protein, human; D054839:Retinol-Binding Proteins, Plasma; C099252:oxidized low density lipoprotein