title: Core-shell Fe3O4@NaLuF4:Yb,Er/Tm nanostructure for MRI, CT and upconversion luminescence tri-modality imaging.
abstract: Core-shell Fe(3)O(4)@NaLuF(4):Yb,Er/Tm nanostructure (MUCNP) with multifunctional properties has been developed using a step-wise synthetic method. The successful fabrication of MUCNP has been confirmed by transmission electron microscopy, powder X-ray diffraction, energy-dispersive X-ray analysis and X-ray photoelectron spectroscopy. The MUCNP exhibits superparamagnetic property with saturation magnetization of 15 emu g(-1), and T(2)-enhanced magnetic resonance (MR) effect with an r(2) value of 21.63 s(-1) mM(-1) at 0.5 T, resulting from the Fe(3)O(4) cores. Moreover, the NaLuF(4)-based MUCNP provides excellent X-ray attenuation and upconversion luminescence (UCL) emission under excitation at 980 nm. In vivo MR, computed tomography (CT) and UCL images of tumor-bearing mice show that the MUCNP can be successfully used in multimodal imaging. In vitro tests reveal that the MUCNP is non-cytotoxic. These results suggest that the developed MUCNP could be served as an MR, CT and UCL probe for tri-modality imaging.
authors.affiliation: Department of Chemistry & Institute of Biomedicine Science & State Key Laboratory of Molecular Engineering of Polymers, Fudan University, 220 Handan Road, Shanghai 200433, PR China.
authors.forename: Xingjun
authors.initials: X
authors.lastname: Zhu
authors.forename: Jing
authors.initials: J
authors.lastname: Zhou
authors.forename: Min
authors.initials: M
authors.lastname: Chen
authors.forename: Mei
authors.initials: M
authors.lastname: Shi
authors.forename: Wei
authors.initials: W
authors.lastname: Feng
authors.forename: Fuyou
authors.initials: F
authors.lastname: Li
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D005260:Female; D005290:Ferric Compounds / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D049449:Luminescence; D008187:Lutetium / Q000737:chemistry*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051379:Mice; D008819:Mice, Nude; D046529:Microscopy, Electron, Transmission; D049329:Nanostructures / Q000009:adverse effects / Q000737:chemistry* / Q000648:ultrastructure; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D005290:Ferric Compounds; C000499:ferric oxide; D008187:Lutetium