title: Case of anti-glomerular basement membrane antibody-induced glomerulonephritis with cytomegalovirus-induced thrombotic microangiopathy.
abstract: Although the involvement of cytomegalovirus (CMV) infections in the development of thrombotic microangiopathy (TMA) in HIV patients and transplant recipients has been reported, it is still controversial whether CMV itself can cause TMA. We report herein a rare case with rapid improvement of TMA by ganciclovir treatment in a patient who is neither HIV-positive nor a transplant recipient, suggesting a pathogenic role for CMV in TMA.
authors.affiliation: Department of Nephrology, Kumamoto University Graduate School of Life Sciences, Kumamoto, Japan. naokis@kumamoto-u.ac.jp
authors.forename: N
authors.initials: N
authors.lastname: Shiraishi
authors.forename: K
authors.initials: K
authors.lastname: Kitamura
authors.forename: M
authors.initials: M
authors.lastname: Hayata
authors.forename: T
authors.initials: T
authors.lastname: Ogata
authors.forename: M
authors.initials: M
authors.lastname: Adachi
authors.forename: K
authors.initials: K
authors.lastname: Kajiwara
authors.forename: H
authors.initials: H
authors.lastname: Ikeda
authors.forename: T
authors.initials: T
authors.lastname: Miyoshi
authors.forename: K
authors.initials: K
authors.lastname: Tomita
mesh_terms: D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use; D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D003404:Creatinine / Q000097:blood; D003587:Cytomegalovirus / Q000472:pathogenicity*; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000188:drug therapy; D005260:Female; D005334:Fever / Q000209:etiology; D015774:Ganciclovir / Q000627:therapeutic use; D050533:Glomerular Basement Membrane / Q000276:immunology*; D005921:Glomerulonephritis / Q000150:complications* / Q000276:immunology; D006801:Humans; D008775:Methylprednisolone / Q000627:therapeutic use; D011239:Prednisolone / Q000627:therapeutic use; D006435:Renal Dialysis; D057049:Thrombotic Microangiopathies / Q000097:blood / Q000209:etiology*; D014766:Viremia / Q000150:complications* / Q000188:drug therapy
chemical_list: D000998:Antiviral Agents; D001323:Autoantibodies; C051951:antiglomerular basement membrane antibody; D011239:Prednisolone; D003404:Creatinine; D015774:Ganciclovir; D008775:Methylprednisolone