title: Subjective and objective assessment of edema during adjuvant chemotherapy for breast cancer using taxane-containing regimens in a randomized controlled trial: The National Surgical Adjuvant Study of Breast Cancer 02.
abstract: OBJECTIVE
  To elucidate the time course of taxane-induced edema which may affect the patients' quality of life (QOL).
  
  
  METHODS
  Our study included the first 300 Japanese patients assigned to 1 of 4 regimens using docetaxel (DTX) or paclitaxel (PTX) by 1:1:1:1 in a randomized controlled trial to evaluate the efficacy of adjuvant therapies for node-positive breast cancer. Patients' QOL was prospectively assessed by the functional assessment of cancer therapy (FACT)-breast and -taxane (FACT-T) subscale. The scores of FACT items regarding edema and body weight were used as indicators of edema.
  
  
  RESULTS
  The scores for 'anasarca', 'edema of the hands' and 'edema of the legs and feet' of the FACT-T subscale worsened up to 1-2 months after chemotherapy, and body weights increased remarkably until cycle 8 in patients treated with DTX alone (75 mg/m(2), 8 cycles, every 3 weeks). Edema-related symptoms and body weight were relatively stable in the other treatment groups. There were statistically significant differences in the scores of those items and in the changes of body weight both between the DTX-alone group and the other three groups combined, and between the groups using DTX and those using PTX.
  
  
  CONCLUSIONS
  Many patients receiving DTX for >4 cycles suffered significantly from edema.
authors.affiliation: Department of Breast Oncology, NHO Shikoku Cancer Center, Matsuyama, Japan. sosumi@shikoku-cc.go.jp
authors.forename: Shozo
authors.initials: S
authors.lastname: Ohsumi
authors.forename: Kojiro
authors.initials: K
authors.lastname: Shimozuma
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Ohashi
authors.forename: Ayano
authors.initials: A
authors.lastname: Takeuchi
authors.forename: Kimito
authors.initials: K
authors.lastname: Suemasu
authors.forename: Masaru
authors.initials: M
authors.lastname: Kuranami
authors.forename: Shinji
authors.initials: S
authors.lastname: Ohno
authors.forename: Toru
authors.initials: T
authors.lastname: Watanabe
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy*; D017024:Chemotherapy, Adjuvant; D000077143:Docetaxel; D004487:Edema / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage; D011379:Prognosis; D011446:Prospective Studies; D011788:Quality of Life; D043823:Taxoids / Q000008:administration & dosage
chemical_list: D043823:Taxoids; D000077143:Docetaxel; D017239:Paclitaxel