title: Evaluation of a generic multi-analyte method for detection of >100 representative compounds correlated to emergency events in 19 food types by ultrahigh-pressure liquid chromatography-tandem mass spectrometry.
abstract: A generic extraction procedure combined with triple quadrupole mass spectrometric detection was evaluated for multi-residue analysis in 19 different foods. Measurable peaks could be obtained at relevant concentrations for 108 out of a total of 127 targeted compounds representing a wide range of physicochemical properties and compound classes related to emergency situations. Recoveries were determined for all 19 foods spiked with the 108 compounds. Seventy-five percent of the compounds had extraction recoveries of 70% or higher, with no compound below 46%. Suppression or enhancement effects on the MS response of the compounds dissolved in the extracts were low, as more than 80% of them had matrix effects between -35% and +20% and no compound was below -44% compared to matrix-free standard. In a validation, all compounds could be quantified at 200 μg/kg and 400 μg/kg food sample and 81% of the compounds at 40 μg/kg. It is concluded that the method is useful for the detection of various types of organic chemical toxicants at levels generally well below concentration thresholds for severe acute intoxication.
authors.affiliation: National Food Agency, Box 622, S-751 26 Uppsala, Sweden. andh@slv.se
authors.forename: Anders
authors.initials: A
authors.lastname: Herrmann
authors.forename: Johan
authors.initials: J
authors.lastname: Rosén
authors.forename: Daniel
authors.initials: D
authors.lastname: Jansson
authors.forename: Karl-Erik
authors.initials: KE
authors.lastname: Hellenäs
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D005504:Food Analysis / Q000379:methods*; D005506:Food Contamination / Q000032:analysis*; D009930:Organic Chemicals / Q000032:analysis; D012680:Sensitivity and Specificity; D053719:Tandem Mass Spectrometry / Q000379:methods*
chemical_list: D009930:Organic Chemicals