title: Distinguishing between polymorphic forms of linezolid by solid-phase electronic and vibrational circular dichroism.
abstract: For the first time two crystalline forms of the same compound (linezolid polymorphs) were investigated by means of the solid-phase ECD and VCD spectra. The ECD spectra show distinct differences and the band at 221 nm serves as a diagnostic one because it is present in form II but absent in form III. The VCD spectra strongly differ in the diagnostic carbonyl absorption range exhibiting two relatively strong bands of opposite signs.
authors.affiliation: Institute of Organic Chemistry of the Polish Academy of Sciences, ul. Kasprzaka 44/52, 01-224 Warsaw, Poland. jadwiga.frelek@icho.edu.pl
authors.forename: Jadwiga
authors.initials: J
authors.lastname: Frelek
authors.forename: Marcin
authors.initials: M
authors.lastname: Górecki
authors.forename: Marta
authors.initials: M
authors.lastname: Laszcz
authors.forename: Agata
authors.initials: A
authors.lastname: Suszczyńska
authors.forename: Elemér
authors.initials: E
authors.lastname: Vass
authors.forename: Wojciech J
authors.initials: WJ
authors.lastname: Szczepek
mesh_terms: D000042:Absorption; D000081:Acetamides / Q000737:chemistry*; D002942:Circular Dichroism; D003460:Crystallization; D007659:Ketones / Q000737:chemistry; D000069349:Linezolid; D023303:Oxazolidinones / Q000737:chemistry*; D011789:Quantum Theory
chemical_list: D000081:Acetamides; D007659:Ketones; D023303:Oxazolidinones; D000069349:Linezolid