title: Forkhead family transcription factor FoxO and neural differentiation.
abstract: The Forkhead Box subgroup O (FoxO) transcription factor family is one of the most important downstream targets of the phosphatidylinositol 3-kinase/protein kinase B signaling pathway playing an important role in many biological functions including transcriptional regulation of cellular differentiation. Neuronal differentiation is a complex process which involves many signaling pathways and molecular mechanisms. Interestingly, recent studies indicate that the FoxO family is involved in a number of signaling pathways regulating cell differentiation. The actions occur at different stages in the differentiation process and by differing mechanisms. This review will focus on FoxO as a novel transcription factor in neural differentiation.
authors.affiliation: Neuropharmacology, School of Pharmaceutical Sciences, Sun Yat-sen University, Higher Education Mega Center, Guangzhou 510006, Guangdong, People's Republic of China.
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wen
authors.forename: Haitao
authors.initials: H
authors.lastname: Wang
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Little
authors.forename: Remi
authors.initials: R
authors.lastname: Quirion
authors.forename: Wenhua
authors.initials: W
authors.lastname: Zheng
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D051858:Forkhead Transcription Factors / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation; D006801:Humans; D009474:Neurons / Q000166:cytology* / Q000378:metabolism*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D051858:Forkhead Transcription Factors; D019869:Phosphatidylinositol 3-Kinases