title: Programmable enantioselective one-pot synthesis of molecules with eight stereocenters.
abstract: We developed an enantioselectively catalyzed tandem synthesis of structurally and stereochemically complex molecules that forms four carbon-carbon bonds and sets eight stereocenters with high regio-, diastereo- and enantioselectivity. It can be programmed to yield different stereoisomers by varying only the order of combination of a common set of reagents and catalysts. We report what is to our knowledge the first synthesis of both enantiomers of a chiral compound using the same chiral catalyst.
authors.affiliation: Max-Planck-Institut für Molekulare Physiologie, Abteilung Chemische Biologie, Dortmund, Germany.
authors.forename: Marco
authors.initials: M
authors.lastname: Potowski
authors.forename: Markus
authors.initials: M
authors.lastname: Schürmann
authors.forename: Hans
authors.initials: H
authors.lastname: Preut
authors.forename: Andrey P
authors.initials: AP
authors.lastname: Antonchick
authors.forename: Herbert
authors.initials: H
authors.lastname: Waldmann
mesh_terms: D001391:Azo Compounds / Q000737:chemistry; D016227:Benzoquinones / Q000138:chemical synthesis*; D002384:Catalysis; D003500:Cyclization; D015394:Molecular Structure; D013237:Stereoisomerism; D013882:Thiosemicarbazones / Q000737:chemistry
chemical_list: D001391:Azo Compounds; D016227:Benzoquinones; D013882:Thiosemicarbazones; C512188:azomethine; C004532:quinone