title: Inflammasomes: far beyond inflammation.
abstract: Nearly a decade ago, the concept of inflammasomes was introduced. Since then, the biochemical characterization of the inflammasomes has led to a richer understanding of innate immune responses in the context of infection and sterile inflammation. This has provided the rationale for successful clinical therapies for a spectrum of hereditary periodic fever syndromes and potentially for some metabolic pathologies.
authors.affiliation: Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.
authors.forename: Jorge
authors.initials: J
authors.lastname: Henao-Mejia
authors.forename: Eran
authors.initials: E
authors.lastname: Elinav
authors.forename: Till
authors.initials: T
authors.lastname: Strowig
authors.forename: Richard A
authors.initials: RA
authors.lastname: Flavell
mesh_terms: D000818:Animals; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D058847:Inflammasomes / Q000276:immunology*; D007249:Inflammation / Q000276:immunology*
chemical_list: D058847:Inflammasomes