title: Subcellular organization: change of phase in partitioning the cellular milieu.
abstract: Spatial organization and segregation are essential for the function of a complex and crowded cellular machine. New work demonstrates liquid-gel phase separation, both in vitro and in vivo, driven by the valency of constituent proteins.
authors.affiliation: Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA 19104-6393, USA.
authors.forename: Joe
authors.initials: J
authors.lastname: Swift
authors.forename: Dennis E
authors.initials: DE
authors.lastname: Discher
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000737:chemistry / Q000502:physiology; D005782:Gels; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry / Q000502:physiology; D008954:Models, Biological; D015513:Oncogene Proteins / Q000737:chemistry / Q000502:physiology; D044367:Phase Transition; D011506:Proteins / Q000737:chemistry / Q000502:physiology*; D013347:Subcellular Fractions / Q000502:physiology*; D051317:Wiskott-Aldrich Syndrome Protein, Neuronal / Q000737:chemistry / Q000502:physiology
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D005782:Gels; D008565:Membrane Proteins; C078332:Nck protein; D015513:Oncogene Proteins; D011506:Proteins; C495771:WASL protein, human; D051317:Wiskott-Aldrich Syndrome Protein, Neuronal; C113267:nephrin