title: Effector and regulatory roles for B cells in HIV infection?
abstract: Toll-like receptor (TLR) signaling has been implicated in the genesis of HIV driven chronic immune activation and inflammation. In other inflammatory diseases, TLR driven B cell regulatory functions have been described, yet in HIV pathogenesis the focus has been on an antibody-dependent role for B cells. In this review, we discuss possible effector and regulatory functions exerted by (TLR) activated B cells during HIV infection.
authors.affiliation: St. Cohn Research Building, Chicago, Illinois 60612, USA. basile.siewe@rush.edu
authors.forename: Basile
authors.initials: B
authors.lastname: Siewe
authors.forename: Alan
authors.initials: A
authors.lastname: Landay
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology*; D060151:B-Lymphocytes, Regulatory / Q000276:immunology; D002450:Cell Communication / Q000276:immunology; D018925:Chemokines / Q000276:immunology / Q000378:metabolism; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D015658:HIV Infections / Q000276:immunology*; D006801:Humans; D018836:Inflammation Mediators / Q000276:immunology
chemical_list: D018925:Chemokines; D016207:Cytokines; D018836:Inflammation Mediators