title: [VIM-2 metallo-ß-lactamase gen detection in a class 1 integron associated to bla(CTX-M-2) in a Pseudomonas aeruginosa clinical isolate in Uruguay: first communication].
abstract: In order to analyze the presence of metallo-ß-lactamase in our country, we included in this study Pseudomonas aeruginosa isolates causing nosocomial infections in a hospital from Uruguay. The presence of a metallo-ß-lactamase VIM-2 in a class 1 integron and of an extended spectrum -lactamase CTX-M-2 was detected in one isolate. This is the first report of both genes, bla(CTX-M-2) and bla(VIM-2),in the same P. aeruginosa isolate. Although carbapenemases have been extensively documented in the world, this is the first report of an acquired metallo-ß-lactamase with carbapenemase activity in pathogenic bacteria in Uruguay.
authors.affiliation: Cátedra de Microbiología, Departamento de Bioquímica Clínica, Facultad de Química, Universidad de la República.
authors.forename: Ana J
authors.initials: AJ
authors.lastname: Ingold
authors.forename: Mercedes
authors.initials: M
authors.lastname: Castro
authors.forename: Adriana
authors.initials: A
authors.lastname: Nabón
authors.forename: Graciela
authors.initials: G
authors.lastname: Borthagaray
authors.forename: Carolina
authors.initials: C
authors.lastname: Márquez
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics*; D015780:Carbapenems / Q000494:pharmacology; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D005798:Genes, Bacterial; D006801:Humans; D032023:Integrons / Q000235:genetics*; D011552:Pseudomonas Infections / Q000453:epidemiology / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000201:enzymology / Q000235:genetics*; D014552:Urinary Tract Infections / Q000453:epidemiology / Q000382:microbiology; D014583:Uruguay / Q000453:epidemiology; D018440:beta-Lactam Resistance / Q000235:genetics*; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D001426:Bacterial Proteins; D015780:Carbapenems; C071167:beta-lactamase CTX-2; C425108:beta-lactamase bla(vim-2); D001618:beta-Lactamases