title: Composite chronic lymphocytic leukemia/small lymphocytic lymphoma and follicular lymphoma are biclonal lymphomas: a report of two cases.
abstract: Composite lymphomas (CLs) consisting of 2 indolent B-cell lymphomas are rare. We present 2 CL cases composed of chronic lymphocytic leukemia (CLL) and follicular lymphoma (FL), each with unique clinicopathologic features. In the first case, the FL was negative for IGH-BCL2 and harbored a novel IGH-associated translocation; in the second case, the CL manifested in the skin. The individual components in both CLs were derived from different B-cell clones. This is the first complete characterization, including molecular analysis, of CLs composed of leukemic CLL and FL and the first report of a cutaneous CL derived from 2 low-grade B cell lymphomas. Our results provide additional supporting evidence that CLs of indolent B-cell lymphomas are biclonal and suggest that they are pathogenetically different from CLs composed of a low-grade B-cell lymphoma and an aggressive B-cell lymphoma or Hodgkin lymphoma, which are usually clonally related.
authors.affiliation: Division of Hematopathology, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065, USA.
authors.forename: Leonardo
authors.initials: L
authors.lastname: Boiocchi
authors.forename: Rosanny Espinal
authors.initials: RE
authors.lastname: Witter
authors.forename: Bing
authors.initials: B
authors.lastname: He
authors.forename: Shivakumar
authors.initials: S
authors.lastname: Subramaniyam
authors.forename: Susan
authors.initials: S
authors.lastname: Mathew
authors.forename: Kui
authors.initials: K
authors.lastname: Nie
authors.forename: Andrea
authors.initials: A
authors.lastname: Cerutti
authors.forename: Morton
authors.initials: M
authors.lastname: Coleman
authors.forename: Daniel M
authors.initials: DM
authors.lastname: Knowles
authors.forename: Attilio
authors.initials: A
authors.lastname: Orazi
authors.forename: Wayne
authors.initials: W
authors.lastname: Tam
mesh_terms: D001402:B-Lymphocytes / Q000473:pathology*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000235:genetics* / Q000473:pathology; D008224:Lymphoma, Follicular / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged