title: The potentials of selected therapeutic targets for inflammation: a snapshot.
abstract: Inflammation is a complex integrated host response to infection and injury. Inflammatory cells respond to foreign substances and inflammatory stimulus by producing various chemical bioactive mediators such as prostanoids, cytokines and chemokines. These mediators have complex, pleiotropic effects and interact with many cell types and cellular pathways to amplify the inflammatory response. Dysregulation of these processes can lead to acute and chronic inflammatory diseases necessitating pharmacological intervention to attenuate cellular inflammation pathways. This review focuses on new targets and alternative approaches to the development of novel therapeutics based on the endogenous chemicals mediators and the regulation of the associated cellular pathways that modulate inflammation leading its resolution and patents relevant to these targets.
authors.affiliation: SPP School of Pharmacy & Technology Management, NMIMS, Vile Parle West, Mumbai, India.
authors.forename: Sneha
authors.initials: S
authors.lastname: Nayadu
authors.forename: Ginpreet
authors.initials: G
authors.lastname: Kaur
authors.forename: Girish
authors.initials: G
authors.lastname: Gudi
authors.forename: Veeranjaneyulu
authors.initials: V
authors.lastname: Addepalli
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D016503:Drug Delivery Systems; D015195:Drug Design; D006801:Humans; D007249:Inflammation / Q000188:drug therapy* / Q000503:physiopathology; D018836:Inflammation Mediators / Q000378:metabolism; D010330:Patents as Topic
chemical_list: D000893:Anti-Inflammatory Agents; D018836:Inflammation Mediators