title: Xanthones with antiproliferative effects on prostate cancer cells from the stem bark of Garcinia xanthochymus.
abstract: Investigations of the constituents of the stem barks of Garcinia xanthochymus have yielded two new compounds, garcinenones X (1) and Y (2), along with five known xanthones, 1,4,5,6-tetrahydroxy-7-(3-methylbut-2-enyl)xanthone (3), 1,4,6-trihydroxy-5-methoxy-7-(3-methylbut-2-enyl)xanthone (4), 1,4,5,6-tetrahydroxy-7,8-di(3-methylbut-2-enyl)xanthone (5), 1,3,5,6-tetrahydroxy-4,7,8-tri(3-methylbut-2-enyl)xanthone (6), and 1,5,6-trihydroxy-7,8-di(3-methylbut-2-enyl)-6',6'dimethylpyrano(2',3':3,4)xanthone (7). The structures of the compounds were determined by spectroscopic methods. The cell growth inhibitory activity of the isolated compounds against the PC-3 cell line was measured. Among them, compounds 2, 3, 5, and 6 exhibited significant inhibitory effects with IG50 values of 14.3, 15.5, 11.1, and 6.8 microM, respectively.
authors.affiliation: Key Laborarory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China.
authors.forename: Feng
authors.initials: F
authors.lastname: Ji
authors.forename: Zhanlin
authors.initials: Z
authors.lastname: Lia
authors.forename: Gaofeng
authors.initials: G
authors.lastname: Liu
authors.forename: Shengli
authors.initials: S
authors.lastname: Niu
authors.forename: Nan
authors.initials: N
authors.lastname: Zhao
authors.forename: Xiaoqiu
authors.initials: X
authors.lastname: Liu
authors.forename: Huiming
authors.initials: H
authors.lastname: Hua
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D045744:Cell Line, Tumor; D029760:Garcinia / Q000737:chemistry*; D006801:Humans; D008297:Male; D024301:Plant Bark / Q000737:chemistry*; D018547:Plant Stems / Q000737:chemistry*; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D044004:Xanthones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D044004:Xanthones