title: The effect of age on the hydroxylation of amylobarbitone sodium in man.
abstract: 1 Following a single oral dose of amylobarbitone sodium it has been shown that a group of young subjects convert a higher proportion of the dose to 3'-hydroxyamylobarbitone than a group of elderly subjects. 2 Twenty-four hours after the administration of the drug, the mean plasma level of amylobarbitone in the elderly group is significantly higher than in the group of young subjects. 3 It is concluded that the rate of hydroxylation of amylobarbitone sodium decreases with age.
authors.affiliation: St Helen's Hospital, Hastings.
authors.forename: R E
authors.initials: RE
authors.lastname: Irvine
authors.forename: J
authors.initials: J
authors.lastname: Grove
authors.forename: P A
authors.initials: PA
authors.lastname: Toseland
authors.forename: J R
authors.initials: JR
authors.lastname: Trounce