title: Repetitive angioscopic observations of a sirolimus-eluting stent deployed in a patient with silent chronic thrombotic occlusion.
abstract: In the era of the drug-eluting stent, very late stent thrombosis has been the most serious issue in the field of interventional cardiology. A sirolimus-eluting stent (SES) was implanted in an in-stent restenotic lesion in the left circumflex artery of a 69-year-old man. Repetitive coronary angiography and angioscopy revealed that stent struts were covered with yellow neointima at 2 years after the SES deployment. At 4 years after the deployment, coronary angiography revealed the total occlusion of the SES. Angioscopy showed massive mural thrombi and yellow atherosclerotic plaques. Dual anti-platelet therapy (DAPT), ticlopidine and aspirin, had been continued since the SES deployment. Interventional cardiologists should heed the risk of silent chronic thrombotic occlusion even if struts of SES are fully covered with neointima under continued DAPT.
authors.affiliation: Department of Cardiology, Higashi-osaka City General Hospital, 3-4-5 Nishi-Iwata, Higashi-osaka, Osaka, 578-8588, Japan. michikawa419@gmail.com
authors.forename: Minoru
authors.initials: M
authors.lastname: Ichikawa
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Kijima
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Mishima
mesh_terms: D000368:Aged; D017546:Angioscopy / Q000379:methods*; D002908:Chronic Disease; D017023:Coronary Angiography / Q000379:methods*; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000473:pathology*; D003328:Coronary Thrombosis / Q000000981:diagnostic imaging / Q000473:pathology*; D003331:Coronary Vessels / Q000473:pathology*; D054855:Drug-Eluting Stents / Q000009:adverse effects*; D006801:Humans; D008297:Male; D020123:Sirolimus / Q000009:adverse effects*
chemical_list: D020123:Sirolimus