title: Host-pathogen interactions revealed by human genome-wide surveys.
abstract: Genome-wide association studies (GWAS) have now convincingly shown that the diverse outcomes (such as the resolution of infection, clinical deterioration to severe disease, or progression from acute infection to persistent infection) that occur following microbial infection can be at least partly explained by human genetic variation. Unbiased whole-genome approaches have revealed unprecedentedly robust associations between genetic markers and susceptibility to disease, providing clear insights into our understanding of infectious disease biology by revealing the crucial host-pathogen interaction sites. Further work characterizing both the host causative variations and pathogenic microbial strains with distinct host interactions and disease outcomes is now required to provide potential new intervention strategies.
authors.affiliation: Infectious Diseases, Genome Institute of Singapore, Singapore.
authors.forename: Chiea Chuen
authors.initials: CC
authors.lastname: Khor
authors.forename: Martin L
authors.initials: ML
authors.lastname: Hibberd
mesh_terms: D003141:Communicable Diseases / Q000235:genetics*; D003625:Data Collection; D020022:Genetic Predisposition to Disease; D015894:Genome, Human / Q000502:physiology; D055106:Genome-Wide Association Study / Q000379:methods; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology / Q000378:metabolism; D054884:Host-Pathogen Interactions / Q000235:genetics*; D006801:Humans; D008954:Models, Biological; D012307:Risk Factors
chemical_list: D006680:HLA Antigens