title: [The estimation of clinical efficacy of eurespal in the postoperative period following surgical intervention on paranasal sinuses].
abstract: The objective of the present study was to estimate the influence of Eurespal (Fenspiride) on the changes of fibrous coating in the nasal cavities, transport function of ciliated epithelium, and dynamics of electrochemical properties of the nasal secretion by means of direct joulemetry following surgical intervention on paranasal sinuses (PNS). The study included 30 patients aged from 18 to 65 years presenting with chronic purulent sinusitis in the phase of exacerbation, polypous rhinosinusitis, and acute pyogenic process in PNS. The results of the study indicate that the use of Eurespal significantly accelerates the recovery of the transport function of intranasal mucociliated epithelium which results in a faster regression of the fibrous coat on intranasal mucosa and mucosal oedema. These changes lead to the improvement of drainage and aeration of the paranasal sinuses.
mesh_terms: D000281:Administration, Intranasal; D000293:Adolescent; D000328:Adult; D000368:Aged; D002908:Chronic Disease; D006801:Humans; D008875:Middle Aged; D009297:Nasal Mucosa / Q000187:drug effects* / Q000503:physiopathology*; D010256:Paranasal Sinuses / Q000187:drug effects / Q000601:surgery*; D011184:Postoperative Period; D012852:Sinusitis / Q000145:classification / Q000188:drug therapy / Q000601:surgery*; D013141:Spiro Compounds / Q000008:administration & dosage* / Q000494:pharmacology; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D013141:Spiro Compounds; C084775:fenspiride