title: Palladium-catalyzed direct arylation of imidazolone N-oxides with aryl bromides and its application in the synthesis of GSK2137305.
abstract: The palladium-catalyzed direct arylation of imidazolone N-oxides with aryl bromides to afford the corresponding 4-aryl imidazolone N-oxides is described. This method has been successfully used for the synthesis of GSK2137305.
authors.affiliation: Medicinal Chemistry Department, AMRI, 26 Corporate Circle, P.O. Box 15098, Albany, New York 12212-5098, USA. He.Zhao@amriglobal.com
authors.forename: He
authors.initials: H
authors.lastname: Zhao
authors.forename: Ruifang
authors.initials: R
authors.lastname: Wang
authors.forename: Ping
authors.initials: P
authors.lastname: Chen
authors.forename: Brian T
authors.initials: BT
authors.lastname: Gregg
authors.forename: Ming Min
authors.initials: MM
authors.lastname: Hsia
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D006842:Hydrocarbons, Brominated / Q000737:chemistry*; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: C572692:GSK2137305; D006842:Hydrocarbons, Brominated; D007093:Imidazoles; D013141:Spiro Compounds; C117197:imidazolone; D010165:Palladium