title: Multimodal imaging and detection strategy with 124 I-labeled chimeric monoclonal antibody cG250 for accurate localization and confirmation of extent of disease during laparoscopic and open surgical resection of clear cell renal cell carcinoma.
abstract: Renal cell carcinoma (RCC) accounts for approximately 85% to 90% of all primary kidney malignancies, with clear cell RCC (ccRCC) constituting approximately 70% to 85% of all RCCs. This study describes an innovative multimodal imaging and detection strategy that uses (124)I-labeled chimeric monoclonal antibody G250 ((124)I-cG250) for accurate preoperative and intraoperative localization and confirmation of extent of disease for both laparoscopic and open surgical resection of ccRCC. Two cases presented herein highlight how this technology can potentially guide complete surgical resection and confirm complete removal of all diseased tissues. This innovative (124)I-cG250 (ie, (124)I-girentuximab) multimodal imaging and detection approach, which would be clinically very useful to urologic surgeons, urologic medical oncologists, nuclear medicine physicians, radiologists, and pathologists who are involved in the care of ccRCC patients, holds great potential for improving the diagnostic accuracy, operative planning and approach, verification of disease resection, and monitoring for evidence of disease recurrence in ccRCC patients.
authors.affiliation: Department of Surgery, The Ohio State University Medical Center, Columbus, OH 43210, USA. stephen.povoski@osumc.edu
authors.forename: Stephen P
authors.initials: SP
authors.lastname: Povoski
authors.forename: Nathan C
authors.initials: NC
authors.lastname: Hall
authors.forename: Douglas A
authors.initials: DA
authors.lastname: Murrey
authors.forename: David S
authors.initials: DS
authors.lastname: Sharp
authors.forename: Charles L
authors.initials: CL
authors.lastname: Hitchcock
authors.forename: Cathy M
authors.initials: CM
authors.lastname: Mojzisik
authors.forename: Eamonn E
authors.initials: EE
authors.lastname: Bahnson
authors.forename: Michael V
authors.initials: MV
authors.lastname: Knopp
authors.forename: Edward W
authors.initials: EW
authors.lastname: Martin
authors.forename: Robert R
authors.initials: RR
authors.lastname: Bahnson
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal; D002292:Carcinoma, Renal Cell / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D007680:Kidney Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D010535:Laparoscopy / Q000379:methods; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging / Q000379:methods; D009392:Nephrectomy / Q000379:methods; D049268:Positron-Emission Tomography; D025321:Surgery, Computer-Assisted / Q000379:methods*; D014057:Tomography, X-Ray Computed
chemical_list: D000911:Antibodies, Monoclonal; C106533:G250 monoclonal antibody; D007457:Iodine Radioisotopes