title: Pecularities of prolonged use of moxonidine in patients with hypertension associated with metabolic syndrome.
abstract: A 6-month clinical study with active therapeutic intervention was carried out to evaluate the efficacy of moxonidine for the correction of arterial hypertension in 30 patients with metabolic syndrome. Along with the metabolic neutrality for the lipid and purine metabolism, the drug demonstrated a distinct antihypertensive effect, which against the background of pronounced sympatholytic action after 3 months of therapy tends to disappear, which can be prevented by dosage correction. It was shown that the efficacy of moxonidine in reducing insulin resistance in patients with metabolic syndrome directly depends on the severity of hypersympathicotonia manifesting in heart rate over 80 bpm at rest.
authors.affiliation: Institute of Pharmacology, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia. viksbest@mail.ru
authors.forename: S I
authors.initials: SI
authors.lastname: Kseneva
authors.forename: E V
authors.initials: EV
authors.lastname: Borodulina
authors.forename: T A
authors.initials: TA
authors.lastname: Semiglazova
authors.forename: N V
authors.initials: NV
authors.lastname: Kulakova
authors.forename: I V
authors.initials: IV
authors.lastname: Tarasova
authors.forename: O Ju
authors.initials: OJ
authors.lastname: Trifonova
authors.forename: T D
authors.initials: TD
authors.lastname: Gridneva
authors.forename: V V
authors.initials: VV
authors.lastname: Udut
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006973:Hypertension / Q000188:drug therapy* / Q000209:etiology; D007093:Imidazoles / Q000627:therapeutic use*; D007333:Insulin Resistance; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications*; D008875:Middle Aged
chemical_list: D000959:Antihypertensive Agents; D007093:Imidazoles; D000324:Adrenocorticotropic Hormone; C043482:moxonidine; D006854:Hydrocortisone