title: SPRIX (ketorolac tromethamine) nasal spray: a novel nonopioid alternative for managing moderate to moderately severe dental pain.
abstract: In summary, SPRIX is a nonopioid alternative for the management of moderate to moderately severe pain. SPRIX offers dentists, physicians, and patients a new non-opioid option to control acute moderate to moderately severe pain in situations in which use of an IM or IV access is not feasible or not wanted. SPRIX is a valuable treatment option for patients with nausea or vomiting, those unable to take oral medications, and those unable to tolerate the side effects of opioids. In ambulatory acute pain settings, use of SPRIX will allow patients who need to remain alert to receive effective pain control. Currently, there are no nonopioid alternatives for the treatment of moderate to moderately severe pain other than ketorolac. In patients with more severe pain states, the combination of opioids and SPRIX provides unique advantages in maximizing analgesia while minimizing the unwanted adverse effects of both classes of drugs (referred to as multimodal or "balanced analgesia").
authors.affiliation: Department of Periodontics, University of Pennsyvania School of Dental Medicine, Philadelphia, Pennsylvania, USA.
authors.forename: Mark B
authors.initials: MB
authors.lastname: Snyder
authors.forename: David B
authors.initials: DB
authors.lastname: Bregmen
mesh_terms: D000005:Abdomen / Q000601:surgery; D000281:Administration, Intranasal; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000009:adverse effects / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D015195:Drug Design; D004347:Drug Interactions; D013509:Gynecologic Surgical Procedures; D006801:Humans; D007273:Injections, Intramuscular; D020911:Ketorolac Tromethamine / Q000008:administration & dosage* / Q000009:adverse effects / Q000737:chemistry; D008964:Molar, Third / Q000601:surgery; D009294:Narcotics / Q000009:adverse effects; D014663:Nasal Decongestants / Q000494:pharmacology; D009293:Opioid-Related Disorders / Q000517:prevention & control; D019647:Oral Surgical Procedures; D019637:Orthopedic Procedures; D010149:Postoperative Pain / Q000188:drug therapy* / Q000517:prevention & control; D011292:Premedication; D016032:Randomized Controlled Trials as Topic; D014095:Tooth, Impacted / Q000601:surgery
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D009294:Narcotics; D014663:Nasal Decongestants; D020911:Ketorolac Tromethamine