title: Comparative evaluation of guided tissue regeneration with use of collagen-based barrier freeze-dried dura mater allograft for mandibular class 2 furcation defects (a comparative controlled clinical study).
abstract: OBJECTIVE
  The aim of periodontal surgery is complete regeneration. The present study was designed to evaluate and compare clinically soft tissue changes in form of probing pocket depth, gingival shrinkage, attachment level and hard tissue changes in form of horizontal and vertical bone level using resorbable membranes.
  
  
  METHODS
  Twelve subjects with bilateral class 2 furcation defects were selected. After initial phase one treatment, open debridement was performed in control site while freezedried dura mater allograft was used in experimental site. Soft and hard tissue parameters were registered intrasurgically. Nine months reentry ensured better understanding and evaluation of the final outcome of the study.
  
  
  RESULTS
  Guided tissue regeneration is a predictable treatment modality for class 2 furcation defect. There was statistically significant reduction in pocket depth as compared to control (p < 0.01). There is statistically significant increase in periodontal attachment level within control and experimental sites showed better results (p < 0.01). For hard tissue parameter, significant defect fill resulted in experimental group, while in control group, less significant defect fill was found in horizontal direction and nonsignificant defect fill was found in vertical direction.
  
  
  CONCLUSIONS
  The results showed statistically significant improvement in soft and hard tissue parameters and less gingival shrinkage in experimental sites compared to control site.
  
  
  CONCLUSIONS
  The use of FDDMA in furcation defects helps us to achieve predictable results. This cross-linked collagen membrane has better handling properties and ease of procurement as well as economic viability making it a logical material to be used in regenerative surgeries.
authors.affiliation: Department of Periodontology, Narsinbhai Patel Dental College, Visnagar, Gujarat, India. docsandip@yahoo.com
authors.forename: Sandeep
authors.initials: S
authors.lastname: Patel
authors.forename: Ajay
authors.initials: A
authors.lastname: Kubavat
authors.forename: Brijesh
authors.initials: B
authors.lastname: Ruparelia
authors.forename: Arvind
authors.initials: A
authors.lastname: Agarwal
authors.forename: Anup
authors.initials: A
authors.lastname: Panda
mesh_terms: D020341:Absorbable Implants; D000328:Adult; D000539:Alveolar Process / Q000473:pathology; D001861:Bone Regeneration / Q000502:physiology; D003094:Collagen; D003646:Debridement; D004388:Dura Mater; D005260:Female; D005612:Freeze Drying; D017823:Furcation Defects / Q000145:classification / Q000601:surgery*; D005889:Gingival Recession / Q000145:classification / Q000601:surgery; D016557:Guided Tissue Regeneration, Periodontal / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D008297:Male; D008336:Mandibular Diseases / Q000145:classification / Q000473:pathology / Q000601:surgery*; D008567:Membranes, Artificial; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000145:classification / Q000601:surgery; D010514:Periodontal Pocket / Q000145:classification / Q000601:surgery; D013524:Surgical Flaps; D014184:Transplantation, Homologous; D016896:Treatment Outcome
chemical_list: D008567:Membranes, Artificial; D003094:Collagen