title: Response of carcinoma in situ (actinic keratosis) to green tea concentrate plus capsicum.
abstract: A single case of carcinoma in situ (actinic keratosis) was treated topically with a patch consisting of an aqueous paste of a commercially available mixture (50:1) of green tea concentrate plus Capsicum (Capsol-T®) for approximately 14 days. The carcinoma responded by the formation of apoptotic blisters whereas surrounding normal tissue showed no response. A second untreated carcinoma 17 cm distant from the treated area also responded indicative of a systemic action of the substance.
authors.affiliation: Department of Medicinal Chemistry and Molecular Pharmacology, Purdue University, West Lafayette, IN 47907, USA. morred@purdue.edu
authors.forename: D James
authors.initials: DJ
authors.lastname: Morré
authors.forename: Christoph C
authors.initials: CC
authors.lastname: Geilen
authors.forename: Anna M
authors.initials: AM
authors.lastname: Welch
authors.forename: Dorothy M
authors.initials: DM
authors.lastname: Morré
mesh_terms: D000287:Administration, Topical; D000368:Aged; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology / Q000627:therapeutic use; D017209:Apoptosis / Q000187:drug effects; D028241:Camellia sinensis; D002212:Capsicum; D002278:Carcinoma in Situ / Q000188:drug therapy*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D006801:Humans; D055623:Keratosis, Actinic / Q000188:drug therapy*; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D012878:Skin Neoplasms / Q000188:drug therapy*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts