title: SERS spectroscopy of kaempferol and galangin under the interaction of human serum albumin with adsorbed silver nanoparticles.
abstract: Raman and surface-enhanced Raman scattering (SERS) spectroscopy were employed to probe the interaction of the flavonol drugs, kaempferol and galangin, with human serum albumin (HSA). SERS spectra of both flavonol derivatives were obtained from a colloidal silver surface in physiological condition, based on the high performance of the enhanced substrate, the most enhanced modes of kaempferol and galangin were those with certain motions perpendicular to the metal surface. The SERS spectra were allowed to predict similar orientation geometry for both of the drugs on the colloidal surface with minor difference. In addition, both flavonols-HSA complexes were prepared in different concentration ratios and the orientated differences between kaempferol and galangin were investigated by SERS.
authors.affiliation: Changchun University of Chinese Medicine, Changchun, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhang
authors.forename: Xueyuan
authors.initials: X
authors.lastname: Bai
authors.forename: Yingping
authors.initials: Y
authors.lastname: Wang
authors.forename: Bing
authors.initials: B
authors.lastname: Zhao
authors.forename: Daqing
authors.initials: D
authors.lastname: Zhao
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000327:Adsorption; D001665:Binding Sites; D004365:Drugs, Chinese Herbal / Q000378:metabolism*; D005419:Flavonoids / Q000378:metabolism*; D006801:Humans; D044949:Kaempferols / Q000378:metabolism*; D053758:Nanoparticles / Q000737:chemistry; D011485:Protein Binding; D012709:Serum Albumin / Q000737:chemistry / Q000378:metabolism*; D012834:Silver / Q000737:chemistry; D013059:Spectrum Analysis, Raman / Q000379:methods
chemical_list: D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D044949:Kaempferols; D012709:Serum Albumin; C037032:galangin; D012834:Silver; C006552:kaempferol