title: Topiramate-induced acute myopia with MRI contrast enhancement.
abstract: Topiramate is a sulfamate-substituted monosaccharide mainly used to treat epilepsy in children and adults and prophylaxis of migraine. This article describes a case of topiramate-induced acute transient myopia. The underlying mechanism and management is discussed. A 13-year-old female complained of sudden onset of blurred vision; 7 days prior to this she had commenced topiramate therapy for migraine prophylaxis. Visual acuity was reduced in both eyes. Examination revealed myopic refractive changes which resolved quickly following discontinuation of the drug. An MRI showed uveoscleral and subcutaneous cellular tissue abnormalities in the T1 contrasted images.
authors.affiliation: Neurology Department, Hospital Privado de Comunidad, Mar del Plata, Argentina. latinifacundo@gmail.com
authors.forename: Manuel Facundo
authors.initials: MF
authors.lastname: Latini
authors.forename: Lucas Martín
authors.initials: LM
authors.lastname: Romano
mesh_terms: D000293:Adolescent; D003287:Contrast Media; D005260:Female; D005632:Fructose / Q000009:adverse effects / Q000031:analogs & derivatives*; D006261:Headache / Q000188:drug therapy; D006801:Humans; D008279:Magnetic Resonance Imaging; D009216:Myopia / Q000139:chemically induced* / Q000175:diagnosis*; D018696:Neuroprotective Agents / Q000009:adverse effects*; D000077236:Topiramate
chemical_list: D003287:Contrast Media; D018696:Neuroprotective Agents; D000077236:Topiramate; D005632:Fructose