title: P-bodies and mitochondria: which place in RNA interference?
abstract: Micro-RNAs (miRNAs) are major actors of RNA interference (RNAi), a regulation pathway which leads to translational repression and/or degradation of specific mRNAs. They provide target specificity by incorporating into the RISC complex and guiding its binding to mRNA. Since the discovery of RNAi, many progresses have been made on the mechanism of action of the RISC complex and on the identification of target mRNAs. However, the regulation of RNAi has been poorly investigated so far. Recently, various studies have revealed physical and functional relationships between RNAi, P-bodies and mitochondria. This review intends to recapitulate these data and discuss their potential importance in cell metabolism.
authors.affiliation: UPMC Univ Paris 06, CNRS-FRE 3402, 9 quai Saint Bernard, Paris, France.
authors.forename: Michèle
authors.initials: M
authors.lastname: Ernoult-Lange
authors.forename: Marianne
authors.initials: M
authors.lastname: Bénard
authors.forename: Michel
authors.initials: M
authors.lastname: Kress
authors.forename: Dominique
authors.initials: D
authors.lastname: Weil
mesh_terms: D000818:Animals; D002460:Cell Line; D003594:Cytoplasmic Granules / Q000235:genetics*; D003600:Cytosol / Q000378:metabolism; D006801:Humans; D035683:MicroRNAs / Q000235:genetics; D008928:Mitochondria / Q000235:genetics*; D034622:RNA Interference
chemical_list: D035683:MicroRNAs