title: Myocardial preservation: controlled reperfusion.
abstract: Reperfusion injury after reestablishing coronary flow by releasing the aortic cross clamp after cardiac surgery with cardioplegic arrest causes myocardial damage and even death. Attenuation of this reperfusion response by controlling the biochemical and physical environment can avoid morbidity and mortality. Use of a warm reperfusate with addition of drugs that are known to decrease reperfusion injury with manipulation of coronary vascular resistance and the physical parameters of the reperfusion environment helps the heart to reestablish coronary perfusion while decreasing the harm produced by the period of ischemia that occurs during cardiac surgery with intermittent cardioplegic arrest.
authors.affiliation: Department of Cardiothoracic and Vascular Surgery, Sri Jayadeva Institute of Cardiovascular Sciences and Research, Bangalore, Karnataka, India. prasannasimha@gmail.com
authors.forename: Prasanna Simha
authors.initials: PS
authors.lastname: Mohan Rao
authors.forename: Parimala Prasanna
authors.initials: PP
authors.lastname: Simha
mesh_terms: D006348:Cardiac Surgical Procedures / Q000009:adverse effects; D002314:Cardioplegic Solutions / Q000008:administration & dosage*; D006324:Heart Arrest, Induced / Q000009:adverse effects; D006801:Humans; D015425:Myocardial Reperfusion / Q000009:adverse effects / Q000379:methods*; D015428:Myocardial Reperfusion Injury / Q000209:etiology / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D002314:Cardioplegic Solutions