title: Sudden death in Leigh syndrome: an autopsy case.
abstract: The present report describes the sudden death of a 3-year-old female child who had been clinically diagnosed with Leigh syndrome.Leigh syndrome is a heterogeneous progressive neurodegenerative disorder, which is characterized by focal or bilateral lesions in the thalamus, basal ganglia, brainstem, cerebellum, and spinal cord. Affected patients exhibit a variable clinical picture that frequently includes psychomotor retardation or regression, recurrent episodes of vomiting, failure to thrive, and signs of brainstem and basal ganglia dysfunction.The child was found dead in bed. Autopsy described the presence of symmetrical, necrotizing lesions scattered within the basal ganglia, thalamus, diencephalon, brainstem, and spinal-cord gray matter and revealed the presence of gastric contents in the upper and lower airways. We report the results of genetic investigations and describe the histological and immunohistochemical features that confirmed the diagnosis. These findings suggest that Leigh syndrome should be regarded as predisposing children to sudden death, especially by asphyxia secondary to the neurological disorder.
authors.affiliation: Department of Legal Medicine, University of Genova, Genova, Italy. ventura@unige.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Ventura
authors.forename: Gabriele
authors.initials: G
authors.lastname: Rocca
authors.forename: Raffaella
authors.initials: R
authors.lastname: Gentile
authors.forename: Francesco
authors.initials: F
authors.lastname: De Stefano
mesh_terms: D001921:Brain / Q000473:pathology; D002675:Child, Preschool; D003645:Death, Sudden / Q000209:etiology*; D005260:Female; D049429:Forensic Pathology; D017353:Gene Deletion; D006801:Humans; D007888:Leigh Disease / Q000150:complications* / Q000235:genetics; D008168:Lung / Q000473:pathology; D008565:Membrane Proteins / Q000235:genetics; D024101:Mitochondrial Proteins / Q000235:genetics; D009154:Mutation; D009336:Necrosis; D011654:Pulmonary Edema / Q000473:pathology; D063466:Respiratory Aspiration of Gastric Contents / Q000473:pathology
chemical_list: D008565:Membrane Proteins; D024101:Mitochondrial Proteins; C092928:Surf-1 protein