title: Noble metal nanoparticles for biosensing applications.
abstract: In the last decade the use of nanomaterials has been having a great impact in biosensing. In particular, the unique properties of noble metal nanoparticles have allowed for the development of new biosensing platforms with enhanced capabilities in the specific detection of bioanalytes. Noble metal nanoparticles show unique physicochemical properties (such as ease of functionalization via simple chemistry and high surface-to-volume ratios) that allied with their unique spectral and optical properties have prompted the development of a plethora of biosensing platforms. Additionally, they also provide an additional or enhanced layer of application for commonly used techniques, such as fluorescence, infrared and Raman spectroscopy. Herein we review the use of noble metal nanoparticles for biosensing strategies--from synthesis and functionalization to integration in molecular diagnostics platforms, with special focus on those that have made their way into the diagnostics laboratory.
authors.affiliation: CIGMH, Departamento de Ciências da Vida, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Campus de Caparica, 2829-516 Caparica, Portugal. doria_go@fct.unl.pt
authors.forename: Gonçalo
authors.initials: G
authors.lastname: Doria
authors.forename: João
authors.initials: J
authors.lastname: Conde
authors.forename: Bruno
authors.initials: B
authors.lastname: Veigas
authors.forename: Leticia
authors.initials: L
authors.lastname: Giestas
authors.forename: Carina
authors.initials: C
authors.lastname: Almeida
authors.forename: Maria
authors.initials: M
authors.lastname: Assunção
authors.forename: João
authors.initials: J
authors.lastname: Rosa
authors.forename: Pedro V
authors.initials: PV
authors.lastname: Baptista
mesh_terms: D015374:Biosensing Techniques; D004867:Equipment Design; D019544:Equipment Failure Analysis; D053768:Metal Nanoparticles / Q000737:chemistry*; D036103:Nanotechnology / Q000295:instrumentation*; D013059:Spectrum Analysis, Raman / Q000295:instrumentation*; D020349:Surface Plasmon Resonance / Q000295:instrumentation*