title: [Studying toxicity caused by interaction of caffeine and ketorolac].
abstract: Combined administration of caffeine and ketorolac (NSAID) is accompanied by all possible types of drug interaction. Side effects of the drug combination are mostly due to the action of ketorolac and manifested by decompensated renal failure and progressive endotoxemia within 3 - 7 days after single administration of drugs. Thus, the amplification of ketorolac effects by caffeine must be taken into consideration in prescribing NSAIDs.
authors.forename: M A
authors.initials: MA
authors.lastname: Iudin
authors.forename: A F
authors.initials: AF
authors.lastname: Kurpiakova
authors.forename: V N
authors.initials: VN
authors.lastname: Bykov
authors.forename: S V
authors.initials: SV
authors.lastname: Chepur
authors.forename: A S
authors.initials: AS
authors.lastname: Nikiforov
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D002110:Caffeine / Q000008:administration & dosage / Q000009:adverse effects*; D004344:Drug Incompatibility; D004347:Drug Interactions; D020910:Ketorolac / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D051381:Rats; D051437:Renal Insufficiency / Q000139:chemically induced*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002110:Caffeine; D020910:Ketorolac