title: Lewis acid-mediated radical cyclization: stereocontrol in cascade radical addition-cyclization-trapping reactions.
abstract: An efficient approach for achieving radical cyclizations by using hydroxamate ester as a coordination tether with Lewis acid was studied. The chiral Lewis acid-mediated cascade radical addition-cyclization-trapping reaction proceeded smoothly with good enantio- and diastereoselectivities, providing various chiral γ-lactams.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kyoto University, Yoshida, Sakyo-ku, Kyoto 606-8501, Japan. miyabe@huhs.ac.jp
authors.forename: Hideto
authors.initials: H
authors.lastname: Miyabe
authors.forename: Ryuta
authors.initials: R
authors.lastname: Asada
authors.forename: Yoshiji
authors.initials: Y
authors.lastname: Takemoto
mesh_terms: D002384:Catalysis; D003500:Cyclization; D005609:Free Radicals / Q000737:chemistry*; D058116:Lewis Acids / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D005609:Free Radicals; D058116:Lewis Acids