title: Phenotypic plasticity of retinal pigment epithelial cells from adult human eye in vitro.
abstract: Phenotypic plasticity of retinal pigment epithelial cells from adult human eye was studied by immunohistochemical methods under different culturing conditions. It was found that retinal pigment epithelium in adult human eye is a heterogeneous population of cells demonstrating different behavior in vitro. Some cells retain epithelial morphology for a long time in culture, while others are rapidly transformed into fibroblast-like cells and synthesize proteins typical of proneural, neural, glial, and photoreceptor cells. However, irrespective of initial morphological features differentiation of retinal pigment cells can be modulated by varying culturing conditions.
authors.affiliation: N. K. Kol'tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, Russia.
authors.forename: L A
authors.initials: LA
authors.lastname: Milyushina
authors.forename: A V
authors.initials: AV
authors.lastname: Kuznetsova
authors.forename: E N
authors.initials: EN
authors.lastname: Grigoryan
authors.forename: M A
authors.initials: MA
authors.lastname: Aleksandrova
mesh_terms: D000328:Adult; D000368:Aged; D002454:Cell Differentiation; D006801:Humans; D066298:In Vitro Techniques; D008875:Middle Aged; D009473:Neuronal Plasticity; D055213:Retinal Pigment Epithelium / Q000166:cytology*