title: Susceptibility testing of Atopobium vaginae for dequalinium chloride.
abstract: BACKGROUND
  Atopobium vaginae and Gardnerella vaginalis are major markers for bacterial vaginosis. We aimed to determine the MIC and MBC range of the broad-spectrum anti-infective and antiseptic dequalinium chloride for 28 strains, belonging to 4 species of the genus Atopobium, i.e. A. vaginae, A. minutum, A. rimae and A. parvulum.
  
  
  METHODS
  The MIC was determined with a broth microdilution assay.
  
  
  RESULTS
  The MIC and MBC for Atopobium spp. for dequalinium chloride ranged between < 0.0625 and 2 μg/ml.
  
  
  CONCLUSIONS
  This study demonstrated that dequalinium chloride inhibits and kills clinical isolates of A. vaginae at concentrations similar to those of clindamycin and lower than those of metronidazole.
authors.affiliation: Laboratory Bacteriology Research, Faculty Medicine & Health Sciences, University of Ghent, Ghent, Belgium. guido.lopesdossantossantiago@ugent.be
authors.forename: Guido
authors.initials: G
authors.lastname: Lopes dos Santos Santiago
authors.forename: Philipp
authors.initials: P
authors.lastname: Grob
authors.forename: Hans
authors.initials: H
authors.lastname: Verstraelen
authors.forename: Florian
authors.initials: F
authors.lastname: Waser
authors.forename: Mario
authors.initials: M
authors.lastname: Vaneechoutte
mesh_terms: D039903:Actinobacteria / Q000187:drug effects* / Q000254:growth & development / Q000302:isolation & purification; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001441:Bacteroides fragilis / Q000187:drug effects* / Q000254:growth & development / Q000302:isolation & purification; D002981:Clindamycin / Q000494:pharmacology; D003470:Culture Media; D003868:Dequalinium / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008795:Metronidazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D014621:Vagina / Q000382:microbiology; D016585:Vaginosis, Bacterial / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D003470:Culture Media; D008795:Metronidazole; D002981:Clindamycin; D003868:Dequalinium