title: [Clinical application of in vitro maturation of human immature oocytes for infertile women with polycystic ovary syndrome].
abstract: OBJECTIVE
  To investigate clinical effect and safety of in vitro maturation (IVM) of human immature oocytes in infertile women with polycystic ovary syndrome by comparing with conventional in vitro fertilization(IVF)and intracytoplasmic sperm injection(ICSI).
  
  
  METHODS
  From Jan. 2003 to Dec. 2009, 157 infertile women with PCOS underwent 162 cycles IVM in Center for Reproductive Medicine, the First Affiliated Hospital of Anhui Medical University. In the mean time, 109 patients with PCOS underwent 114 IVF/ICSI cycles as control group 1 and 106 patients with other factors underwent 106 IVF/ICSI cycles as control group 2. Treatment and outcome of pregnancy and infant were compared among those 3 groups.
  
  
  RESULTS
  No statistically significant difference were found in terms of the positive rate of hCG in urine [35.7% (56/157), 42.2% (46/109), 44.3% (47/106)], the rate of clinical pregnancy [29.3% (46/157), 37.6% (41/109), 41.5% (44/106)], the rate of entopic pregnancy [1.9% (3/157), 1.8% (2/109), 0.9% (1/106)], the rate of miscarriage [18.6% (8/43), 12.8% (5/39), 20.9% (9/43)] and the rate of live-birth [22.3% (35/157), 31.2% (34/109), 32.1% (34/106)] among three groups (IVM group, control group 1, control group 2, P > 0.05). The rate of preterm labor, low weight newborn, mean birth weight, ratio of male to female did not show significantly difference among 3 groups (P > 0.05). The average control ovarian stimulation was 6 days, the median dose of gonadotropin (Gn) was 675 IU, and the total hospital cost was (8392 ± 1328) RMB in IVM group, which were statistically lower than those in the other two control groups (P < 0.01). The rate of multiple pregnancy was 4.7% (2/43) and ovarian hyperstimulation syndrome (OHSS) 0 in IVM group, which were significantly lower than those in the other control group (P < 0.01).
  
  
  CONCLUSIONS
  In vitro maturation is an effective treatment in infertile women with PCOS, it could obtain the similar pregnancy outcome and reduce total cost, the dosage of gonadotropin-releasing hormone and rate of OHSS compared with conventional IVF/ICSI.
authors.affiliation: Center of Reproductive Medicine, the First Affiliated Hospital of Anhui Medical University, Hefei 230061, China.
authors.forename: Yu-ping
authors.initials: YP
authors.lastname: Xu
authors.forename: Hui-fen
authors.initials: HF
authors.lastname: Xiang
authors.forename: Wei-wei
authors.initials: WW
authors.lastname: Zou
authors.forename: Ze-lian
authors.initials: ZL
authors.lastname: Li
authors.forename: Zhi-guo
authors.initials: ZG
authors.lastname: Zhang
authors.forename: Ping
authors.initials: P
authors.lastname: Zhou
authors.forename: Yun-xia
authors.initials: YX
authors.lastname: Cao
mesh_terms: D000328:Adult; D001724:Birth Weight; D016022:Case-Control Studies; D018929:Cell Culture Techniques; D002478:Cells, Cultured; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007231:Infant, Newborn; D007247:Infertility, Female / Q000209:etiology / Q000628:therapy*; D008297:Male; D009865:Oocytes / Q000166:cytology / Q000502:physiology*; D009866:Oogenesis; D010062:Ovulation Induction / Q000379:methods; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000628:therapy*; D011247:Pregnancy; D011256:Pregnancy Outcome; D027724:Reproductive Techniques, Assisted; D012189:Retrospective Studies