title: Antioxidant SMe1EC2 may attenuate the disbalance of sodium homeostasis in the organism induced by higher intake of cholesterol.
abstract: The study was focused to the influence of higher intake of cholesterol on properties of the renal Na,K-ATPase, a key system in maintaining the homeostasis of sodium in the organism. Feeding for 4 weeks with cholesterol-enriched food for rats afflicted with hereditary hypertriglyceridemia by itself enhanced the activity of Na,K-ATPase, probably as a consequence of higher number of active enzyme molecules as suggested by 32 % increase of V (max) value. This may be hypothesized as a reason for the increased retention of sodium. Three-week-lasting treatment of animals kept on high cholesterol diet with antioxidant SMe1EC2 in a dose of 10 mg kg(-1) day(-1) normalized the function of renal Na,K-ATPase to the level comparable in hypertriglyceridemic rats fed with the standard diet. Therefore, our results suggest that the antioxidant SMe1EC2 in the applied dose seems to be effective in the attenuation of cholesterol-induced retention of sodium. Treatment for 3 weeks with Fenofibrate in a dose of 100 mg kg(-1) day(-1) reversed the function of renal Na,K-ATPase only slightly.
authors.affiliation: Institute for Heart Research, Department of Biochemistry, Slovak Academy of Sciences, Dúbravská cesta 9, P.O. Box 104, 840 05, Bratislava 45, Slovak Republic.
authors.forename: Lucia
authors.initials: L
authors.lastname: Mézešová
authors.forename: Veronika
authors.initials: V
authors.lastname: Jendruchová-Javorková
authors.forename: Jana
authors.initials: J
authors.lastname: Vlkovičová
authors.forename: Zuzana
authors.initials: Z
authors.lastname: Kyselova
authors.forename: Jana
authors.initials: J
authors.lastname: Navarová
authors.forename: Stefan
authors.initials: S
authors.lastname: Bezek
authors.forename: Norbert
authors.initials: N
authors.lastname: Vrbjar
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000009:adverse effects*; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006706:Homeostasis / Q000187:drug effects*; D006953:Hyperlipoproteinemia Type IV / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D007211:Indoles / Q000494:pharmacology* / Q000627:therapeutic use; D007668:Kidney / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D007700:Kinetics; D008297:Male; D009929:Organ Size; D018384:Oxidative Stress; D011506:Proteins / Q000378:metabolism; D011725:Pyridines / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D012964:Sodium / Q000378:metabolism*; D000254:Sodium-Potassium-Exchanging ATPase; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014280:Triglycerides / Q000097:blood
chemical_list: D000975:Antioxidants; D002791:Cholesterol, Dietary; D007211:Indoles; D011506:Proteins; D011725:Pyridines; C534359:SMe1EC2; D017392:Thiobarbituric Acid Reactive Substances; D014280:Triglycerides; D002784:Cholesterol; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase