title: Intraperitoneal administration of daptomycin in recurrent peritonitis with suspected biofilm.
abstract: Forms of peritonitis are the most problematic infections in patients undergoing peritoneal dialysis since they can jeopardise the technique. Current treatment includes administering vancomycin, cephalosporins and aminoglycosides empirically until the cause of the infection is known. However, the current situation with regard to emerging bacterial resistances makes it necessary to include new drugs in the therapeutic array for complicated forms of peritonitis that may become recurrent and compromise dialyser efficacy. Daptomycin is a lipopeptide antibiotic used to treat gram-positive bacterial infections. It has not yet been approved for treatment of infections of this type, but it is starting to be used in this area due to being highly effective against methicillin-resistant bacteria with intermediate sensitivity to vancomycin, particularly when the bacteria are associated with biofilm formation.
authors.affiliation: Servicio de Farmacia Hospitalaria, Hospital General de Segovia, Segovia. Spain. laugarcilo@yahoo.es
authors.forename: Laura
authors.initials: L
authors.lastname: García-López
authors.forename: M José
authors.initials: MJ
authors.lastname: Fernández-Reyes Luis
authors.forename: M Teresa
authors.initials: MT
authors.lastname: Criado-Illana
authors.forename: Leonor
authors.initials: L
authors.lastname: Gómez-Sayago
authors.forename: Manuel
authors.initials: M
authors.lastname: Heras-Benito
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D018407:Bacterial Physiological Phenomena; D018441:Biofilms; D017576:Daptomycin / Q000008:administration & dosage*; D006801:Humans; D007274:Injections, Intraperitoneal; D010538:Peritonitis / Q000188:drug therapy* / Q000382:microbiology*; D012008:Recurrence
chemical_list: D000900:Anti-Bacterial Agents; D017576:Daptomycin