title: Immunostimulatory effect of gold nanoparticles conjugated with transmissible gastroenteritis virus.
abstract: Animals were immunized with transmissible gastroenteritis virus conjugated with gold nanoparticles. The resultant antibodies had a higher titer than antibodies produced in response to native virus. Immunization with the antigen-colloidal gold complex led to a significant increase of the peritoneal macrophages respiratory activity and of plasma IFN-γ level in immunized animals.
authors.affiliation: Institute of Plant and Microorganism Biochemistry and Physiology, Russian Academy of Sciences, Saratov, Russia.
authors.forename: S A
authors.initials: SA
authors.lastname: Staroverov
authors.forename: I V
authors.initials: IV
authors.lastname: Vidyasheva
authors.forename: K P
authors.initials: KP
authors.lastname: Gabalov
authors.forename: O A
authors.initials: OA
authors.lastname: Vasilenko
authors.forename: V N
authors.initials: VN
authors.lastname: Laskavyi
authors.forename: L A
authors.initials: LA
authors.lastname: Dykman
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D006046:Gold / Q000737:chemistry*; D007371:Interferon-gamma / Q000097:blood; D017737:Macrophages, Peritoneal / Q000276:immunology*; D053768:Metal Nanoparticles; D051379:Mice; D011817:Rabbits; D005760:Transmissible gastroenteritis virus / Q000276:immunology*; D014765:Viral Vaccines / Q000008:administration & dosage* / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D014765:Viral Vaccines; D006046:Gold; D007371:Interferon-gamma