title: Live-cell monitoring of the glutathione-triggered release of the anticancer drug topotecan on gold nanoparticles in serum-containing media.
abstract: The intracellular glutathione-triggered release of the anticancer drug topotecan from gold nanoparticles in serum-containing media was directly monitored in real time using a label-free fluorescence live-cell imaging technique.
authors.affiliation: Department of Soongsil University, Seoul 156-743, Korea.
authors.forename: Mira
authors.initials: M
authors.lastname: Kim
authors.forename: Kwangsu
authors.initials: K
authors.lastname: Ock
authors.forename: Keunchang
authors.initials: K
authors.lastname: Cho
authors.forename: Sang-Woo
authors.initials: SW
authors.lastname: Joo
authors.forename: So Yeong
authors.initials: SY
authors.lastname: Lee
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism* / Q000627:therapeutic use; D045744:Cell Line, Tumor; D003470:Culture Media; D005978:Glutathione / Q000737:chemistry / Q000378:metabolism*; D006046:Gold / Q000737:chemistry*; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry*; D051379:Mice; D018613:Microscopy, Confocal; D009369:Neoplasms / Q000188:drug therapy; D019772:Topotecan / Q000378:metabolism* / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D003470:Culture Media; D006046:Gold; D019772:Topotecan; D005978:Glutathione