title: One-year results of vital pulp therapy in permanent molars with irreversible pulpitis: an ongoing multicenter, randomized, non-inferiority clinical trial.
abstract: OBJECTIVE
  Root canal therapy (RCT) and tooth extraction have been conventional treatment options for management of human mature teeth with irreversible pulpitis. Excellent short-term treatment outcomes of vital pulp therapy with calcium-enriched mixture cement (VPT/CEM), as a new treatment option, on postoperative pain relief was demonstrated; if intermediate- and long-term treatment outcomes of the new treatment are also non-inferior compared to RCT, then VPT/CEM may become a viable treatment option for management of mature teeth with irreversible pulpitis.
  
  
  METHODS
  In 23 healthcare centers, 407 9- to 65-year-old patients were randomly allocated into two study arms including one-visit RCT (reference treatment; n = 202) and VPT/CEM (alternative treatment; n = 205). Six- and twelve-month clinical and radiographic successes were assessed.
  
  
  RESULTS
  Mean follow-up times at 6- and 12-month follow-ups were "6.70 ± 0.68 and 6.72 ± 0.71 months" and "12.96 ± 0.67 and 12.90 ± 0.66 months" in the available cases of RCT and VPT/CEM arms, respectively. Favorable clinical success rates in the two study arms did not show statistical difference; however, the radiographic success rate in the VPT/CEM was significantly greater than RCT arm at the two follow-ups (P < 0.001). The patients' age had no effect on the treatment outcomes (P = 0.231).
  
  
  CONCLUSIONS
  Treatment outcomes of VPT/CEM may be superior to RCT in mature molars with irreversible pulpitis. The performance of biomaterials such CEM cement may assist in the shift towards more biologic treatments.
  
  
  CONCLUSIONS
  VPT/CEM may be a realistic alternative treatment for human mature molar teeth with symptoms of irreversible pulpitis; the use of VPT/CEM is highly beneficial for patients as well as general dentists.
authors.affiliation: Iranian Center for Endodontic Research, Shahid Beheshti University of Medical Sciences, Evin, 1983963113 Tehran, Iran. saasgary@yahoo.com
authors.forename: Saeed
authors.initials: S
authors.lastname: Asgary
authors.forename: Mohammad Jafar
authors.initials: MJ
authors.lastname: Eghbal
authors.forename: Jamileh
authors.initials: J
authors.lastname: Ghoddusi
authors.forename: Shahram
authors.initials: S
authors.lastname: Yazdani
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D017610:Calcium Compounds / Q000627:therapeutic use; D002648:Child; D004853:Epoxy Resins / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006171:Gutta-Percha / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D008963:Molar / Q000000981:diagnostic imaging / Q000473:pathology*; D010486:Periapical Tissue / Q000000981:diagnostic imaging / Q000473:pathology; D057872:Pulp Capping and Pulpectomy Agents / Q000627:therapeutic use; D011671:Pulpitis / Q000000981:diagnostic imaging / Q000628:therapy*; D011672:Pulpotomy / Q000379:methods*; D011859:Radiography; D012387:Root Canal Filling Materials / Q000627:therapeutic use; D018915:Root Canal Preparation / Q000295:instrumentation / Q000379:methods; D012390:Root Canal Therapy / Q000379:methods; D016896:Treatment Outcome; D014945:Wound Healing / Q000502:physiology; D055815:Young Adult
chemical_list: D017610:Calcium Compounds; D004853:Epoxy Resins; D057872:Pulp Capping and Pulpectomy Agents; D012387:Root Canal Filling Materials; C534916:epoxy resin-based root canal sealer; D006171:Gutta-Percha