title: Advanced life support and mechanical ventilation.
abstract: OBJECTIVE
  Artificial ventilation is one of the best known resuscitation procedures. It is generally accepted that there must be oxygen delivery to vital organs during cardiac arrest and resuscitation in order to prevent irreversible damage, but there is an increasing number of ventilation concepts for resuscitation. Traditional and alternative methods of ventilation are reviewed.
  
  
  RESULTS
  The need for positive-pressure ventilation during resuscitation as an essential gold standard might be overestimated at least in the first minutes of cardiopulmonary resuscitation (CPR). The co-founders of the concept of cardiocerebral resuscitation could show positive effects of a sole passive oxygenation at the beginning of advanced life support (ALS). Research was published on continuous positive airway pressure (CPAP) ventilation as well as on CPAP plus pressure support ventilation. In addition to positive-pressure ventilation, the use of an impedance threshold device, partly in addition with active compression-decompression CPR, was investigated in both experimental and clinical settings. None of these methods alone could be proven to improve the outcome of cardiac arrest. The role of high oxygen concentration during CPR also remains unclear.
  
  
  CONCLUSIONS
  Positive-pressure ventilation with pure oxygen remains, in clinical practice, the gold standard in ALS. Further research should focus on the role of passive oxygenation during early ALS. The concentration of oxygen needed during resuscitation has to be defined and alternative ventilation patterns, regarding the impact of CPR, should be investigated.
authors.affiliation: Department of Anaesthesiology and Critical Care, Philipps-University, and Department of Emergency Medicine, University Hospital Giessen, Marburg, Germany. killc@staff.uni-marburg.de
authors.forename: Clemens
authors.initials: C
authors.lastname: Kill
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Dersch
authors.forename: Hinnerk
authors.initials: H
authors.lastname: Wulf
mesh_terms: D016887:Cardiopulmonary Resuscitation / Q000379:methods*; D002986:Clinical Trials as Topic; D006323:Heart Arrest / Q000628:therapy*; D006801:Humans; D008020:Life Support Care / Q000379:methods*; D010102:Oxygen Inhalation Therapy / Q000379:methods*; D011175:Positive-Pressure Respiration / Q000379:methods; D012121:Respiration, Artificial / Q000379:methods*