title: Treatment outcome of HIV-associated tuberculosis in a resource-poor setting.
abstract: Nigeria is among the countries with the world's highest tuberculosis (TB) burden, and HIV/TB co-infection is an important cause of mortality. We evaluate the treatment outcome of HIV-infected TB patients in Abakaliki, Nigeria. A retrospective cohort study of all TB patients registered at a tertiary hospital between January 2006 and December 2010 was conducted. Of 671 TB patients, 189 (28.2%) were HIV co-infected. Of these, 147 (77.8%) had pulmonary TB and 42 (22.2%) had extra-pulmonary TB. The overall treatment success rate was 52.4% (n = 99) and the defaulted in treatment rate was 30.2% (n = 57). Twenty-one (11.1%) died, and one (0.5%) had treatment failure. Younger age group (<15 years; P = 0.0024) and smear-positive status (P = 0.0056) were independent predictors of successful treatment. TB/HIV co-infection is associated with high mortality and alarming default rates during treatment.
authors.affiliation: Department of Medicine, Federal Medical Centre, Abakaliki, Nigeria.
authors.forename: Ngozi A
authors.initials: NA
authors.lastname: Ifebunandu
authors.forename: Kingsley N
authors.initials: KN
authors.lastname: Ukwaja
authors.forename: Samuel N
authors.initials: SN
authors.lastname: Obi
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology; D000293:Adolescent; D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use*; D015331:Cohort Studies; D060085:Coinfection; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006295:Health Resources; D006801:Humans; D008297:Male; D009549:Nigeria / Q000453:epidemiology; D011203:Poverty; D015995:Prevalence; D016896:Treatment Outcome; D014376:Tuberculosis / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000188:drug therapy* / Q000453:epidemiology; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents