title: Preeclampsia (marker of chronic kidney disease): from genesis to future risks.
abstract: Preeclampsia (PE) is a pregnancy-specific disease which, in addition to other hypertensive disorders, is an important cause of maternal and perinatal morbidity and mortality. With an incidence ranging from 3 to 14% of all pregnancies worldwide, the disease can present in different clinical forms. PE and cardiovascular diseases (CVD) have similar pathophysiological mechanisms, such as endothelial dysfunction, metabolic changes and oxidative stress, and they also share some risk factors such as obesity, kidney disease and diabetes. Although the exact relationship between PE and cardiovascular risk has not been fully elucidated, PE-triggered metabolic stress may cause vascular injury, thus contributing to the development of CVD and/or chronic kidney disease (CKD) in the future. This risk appears to be increased especially in women with a history of recurrent, severe PE and eclampsia. The investigation of a history of PE may assist in assessing the future risk of CVD and CKD, their prevention and early diagnosis.
authors.affiliation: Departamento de Obstetrícia da Escola Paulista de Medicina – EPM da Universidade Federal de São Paulo – UNIFESP, Setor de Hipertensão Arterial e Nefropatias na Gestação.
authors.forename: Thais Alquezar
authors.initials: TA
authors.lastname: Facca
authors.forename: Gianna Mastroianni
authors.initials: GM
authors.lastname: Kirsztajn
authors.forename: Nelson
authors.initials: N
authors.lastname: Sass
mesh_terms: D002318:Cardiovascular Diseases / Q000209:etiology; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia; D011247:Pregnancy; D011379:Prognosis; D011507:Proteinuria / Q000209:etiology; D051436:Renal Insufficiency, Chronic / Q000209:etiology* / Q000517:prevention & control; D012307:Risk Factors