title: Infection of specific strains of Streptococcus mutans, oral bacteria, confers a risk of ulcerative colitis.
abstract: Although oral bacteria-associated systemic diseases have been reported, association between Streptococcus mutans, pathogen of dental caries, and ulcerative colitis (UC) has not been reported. We investigated the effect of various S. mutans strains on dextran sodium sulfate (DSS)-induced mouse colitis. Administration of TW295, the specific strain of S. mutans, caused aggravation of colitis; the standard strain, MT8148 did not. Localization of TW295 in hepatocytes in liver was observed. Increased expression of interferon-γ in liver was also noted, indicating that the liver is target organ for the specific strain of S. mutans-mediated aggravation of colitis. The detection frequency of the specific strains in UC patients was significantly higher than in healthy subjects. Administration of the specific strains of S. mutans isolated from patients caused aggravation of colitis. Infection with highly-virulent specific types of S. mutans might be a potential risk factor in the aggravation of UC.
authors.affiliation: Department of Pediatric Dentistry, Graduate School of Dentistry, Osaka University, Osaka, 565-0871, Japan.
authors.forename: Ayuchi
authors.initials: A
authors.lastname: Kojima
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Nakano
authors.forename: Koichiro
authors.initials: K
authors.lastname: Wada
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Takahashi
authors.forename: Kazufumi
authors.initials: K
authors.lastname: Katayama
authors.forename: Masato
authors.initials: M
authors.lastname: Yoneda
authors.forename: Takuma
authors.initials: T
authors.lastname: Higurashi
authors.forename: Ryota
authors.initials: R
authors.lastname: Nomura
authors.forename: Kazuya
authors.initials: K
authors.lastname: Hokamura
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Muranaka
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Matsuhashi
authors.forename: Kazuo
authors.initials: K
authors.lastname: Umemura
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Kamisaki
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nakajima
authors.forename: Takashi
authors.initials: T
authors.lastname: Ooshima
mesh_terms: D000818:Animals; D003093:Colitis, Ulcerative / Q000382:microbiology*; D016207:Cytokines / Q000096:biosynthesis; D006801:Humans; D008099:Liver / Q000382:microbiology; D051379:Mice; D009055:Mouth / Q000382:microbiology*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012307:Risk Factors; D013295:Streptococcus mutans / Q000472:pathogenicity*
chemical_list: D016207:Cytokines