title: Analgesic and antipyretic activities of ethanol extract of Stereospermum suaveolens.
abstract: Ethanol extract from the stem bark of Stereospermum suaveolens (Roxb.) DC (Bignoniaceae), given orally at the doses of 200 and 400 mg/kg body weight, was assessed for analgesic and antipyretic properties on different experimental animal models. Administration of ethanol extract of Stereospermum suaveolens (EESS) produced significant (p < .05, p < .001) dose-dependent analgesic effect in the tail flick, hot plate, and tail clip (central) as well as in acetic acid-induced writhing (peripheral) nociceptive tests in mice, suggesting the involvement of both central and peripheral mechanisms in alleviating the pain response. In the current study, indomethacin, aspirin, and morphine were used as the standard analgesic drugs. In addition, EESS also exhibited a significant (p < .05, p < .001) dose-dependent antipyretic response in Brewer's yeast-induced pyrexia in rats and the results were comparable with that of paracetamol, a standard antipyretic agent. These results showed that the EESS possesses potent analgesic and antipyretic activity by dose-dependent manner, in various experimental animal models.
authors.affiliation: Division of Pharmacology, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, India. tbaluenandhi@rediffmail.com
authors.forename: T Balasubramanian
authors.initials: TB
authors.lastname: Mpharm
authors.forename: Chatterjee Tapan
authors.initials: CT
authors.lastname: Kumar
mesh_terms: D000082:Acetaminophen / Q000494:pharmacology / Q000627:therapeutic use; D019342:Acetic Acid; D000700:Analgesics / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D058633:Antipyretics / Q000494:pharmacology / Q000627:therapeutic use*; D001522:Behavior, Animal / Q000187:drug effects; D029402:Bignoniaceae; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D005334:Fever / Q000188:drug therapy*; D006358:Hot Temperature; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009420:Nervous System / Q000187:drug effects; D010146:Pain / Q000188:drug therapy*; D008517:Phytotherapy; D024301:Plant Bark; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D018547:Plant Stems; D051381:Rats; D017208:Rats, Wistar; D012441:Saccharomyces cerevisiae
chemical_list: D000700:Analgesics; D058633:Antipyretics; D010936:Plant Extracts; D000082:Acetaminophen; D019342:Acetic Acid