title: Chemical composition and in vitro schistosomicidal activity of the essential oil from the flowers of Bidens sulphurea (Asteraceae).
abstract: In this study, the chemical composition and the in vitro schistosomicidal properties of the essential oil obtained from Bidens sulphurea flowers (Bs-EO) were investigated. Its major constituents were identified as being 2,6-di-tert-butyl-4-methylphenol (44.98%), germacrene D (33.70%) and β-caryophyllene (10.23%). Bs-EO at 100 µg mL(-1) caused death of all the adult worms and promoted separation of the couple pairs into individual male and female within 48 h, besides leading to a significant decrease in the motility of the parasites. This oil was also responsible for a remarkable reduction in the number of eggs and the percentage of developed eggs produced by adult worms. These results suggest that the Bs-EO can be considered a promising source for the development of new schistosomicidal agents.
authors.affiliation: Núcleo de Pesquisas em Ciências Exatas e Tecnológicas, Universidade de Franca, Franca, SP, Brazil.
authors.forename: G P
authors.initials: GP
authors.lastname: Aguiar
authors.forename: N I
authors.initials: NI
authors.lastname: Melo
authors.forename: K A L
authors.initials: KA
authors.lastname: Wakabayashi
authors.forename: M H S
authors.initials: MH
authors.lastname: Lopes
authors.forename: A L L
authors.initials: AL
authors.lastname: Mantovani
authors.forename: H J
authors.initials: HJ
authors.lastname: Dias
authors.forename: M J
authors.initials: MJ
authors.lastname: Fukui
authors.forename: L C
authors.initials: LC
authors.lastname: Keles
authors.forename: V
authors.initials: V
authors.lastname: Rodrigues
authors.forename: M
authors.initials: M
authors.lastname: Groppo
authors.forename: A A
authors.initials: AA
authors.lastname: Silva-Filho
authors.forename: W R
authors.initials: WR
authors.lastname: Cunha
authors.forename: L G
authors.initials: LG
authors.lastname: Magalhães
authors.forename: A E M
authors.initials: AE
authors.lastname: Crotti
mesh_terms: D000818:Animals; D019659:Asteraceae / Q000737:chemistry*; D035264:Flowers / Q000737:chemistry*; D009822:Oils, Volatile / Q000737:chemistry* / Q000494:pharmacology*; D000081223:Polycyclic Sesquiterpenes; D012556:Schistosomicides / Q000737:chemistry* / Q000494:pharmacology*; D012717:Sesquiterpenes / Q000737:chemistry / Q000494:pharmacology; D045788:Sesquiterpenes, Germacrane / Q000737:chemistry / Q000494:pharmacology
chemical_list: D009822:Oils, Volatile; D000081223:Polycyclic Sesquiterpenes; D012556:Schistosomicides; D012717:Sesquiterpenes; D045788:Sesquiterpenes, Germacrane; C024714:caryophyllene; C027259:germacrene D