title: Lapacho tea (Tabebuia impetiginosa) extract inhibits pancreatic lipase and delays postprandial triglyceride increase in rats.
abstract: Earlier work in our laboratory indicated that ethanolic extracts of Tabebuia impetiginosa, Arctium lappa L., Calendula officinalis, Helianthus annuus, Linum usitatissimum and L. propolis, inhibit pancreatic lipase in vitro. In a follow-up study we assessed their effects on plasma triglycerides in rats fed on a fatty meal. Extracts, orlistat or only ethanol were given orally to the rats together with the test meal and the rate of increase of postprandial triglycerides was assessed over 4 h. Clearing of the triglycerides from the blood compartment was abolished by inhibiting lipoprotein lipase with Triton WR-1339. Our results showed that out of all the extracts, the bark of Tabebuia impetiginosa led to a significant delay in the postprandial increase of plasma triglycerides. However, lapachol, which is contained in the bark of Tabebuia impetiginosa and soluble in ethanol, had no lipase inhibitory effect in vitro and hence this substance did not seem to mediate the pertinent effect.
authors.affiliation: Max Rubner-Institute, Federal Research Institute of Nutrition and Food, Department of Microbiology and Biotechnology, Kiel, Germany.
authors.forename: Beatrice Nyanchama
authors.initials: BN
authors.lastname: Kiage-Mokua
authors.forename: Nils
authors.initials: N
authors.lastname: Roos
authors.forename: Jürgen
authors.initials: J
authors.lastname: Schrezenmeir
mesh_terms: D000818:Animals; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D008049:Lipase / Q000037:antagonists & inhibitors*; D008071:Lipoprotein Lipase / Q000037:antagonists & inhibitors; D008297:Male; D009285:Naphthoquinones / Q000494:pharmacology; D024301:Plant Bark / Q000737:chemistry; D010936:Plant Extracts / Q000494:pharmacology*; D019518:Postprandial Period / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D029663:Tabebuia / Q000737:chemistry*; D014280:Triglycerides / Q000097:blood
chemical_list: D004791:Enzyme Inhibitors; D009285:Naphthoquinones; D010936:Plant Extracts; D014280:Triglycerides; C008252:lapachol; D008049:Lipase; D008071:Lipoprotein Lipase