title: [Evaluation of antiepileptic effects of cortexin in a model of convulsions].
abstract: We studied antiepileptic effects of cortexin administered in doses 0,015, 0,15 and 1,0 mg/kg intraperitoneally in solution or intranasally in the complex with nanoparticles in a model of acute and chronic convulsions in rats induced by pentylenetetrazole. In the model of epileptic status, the long-term preliminary administration of cortexin had no effect on convulsions while in the model of chronic convulsions (temporal epilepsy), cortexin had a marked dose-dependent antiepileptic effect. The influence of cortexin on neuroplasticity and its clinical potential are discussed.
authors.forename: V A
authors.initials: VA
authors.lastname: Aniol
authors.forename: Iu
authors.initials: Iu
authors.lastname: Novitskaia
authors.forename: T N
authors.initials: TN
authors.lastname: Borodina
authors.forename: T V
authors.initials: TV
authors.lastname: Bukreeva
authors.forename: N A
authors.initials: NA
authors.lastname: Lazareva
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Moiseeva
authors.forename: M V
authors.initials: MV
authors.lastname: Onufriev
authors.forename: M Iu
authors.initials: MIu
authors.lastname: Stepanichev
authors.forename: A A
authors.initials: AA
authors.lastname: Iakovlev
authors.forename: A B
authors.initials: AB
authors.lastname: Gekht
authors.forename: O K
authors.initials: OK
authors.lastname: Granstrem
authors.forename: N V
authors.initials: NV
authors.lastname: Guliaeva
mesh_terms: D000281:Administration, Intranasal; D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage*; D004195:Disease Models, Animal; D036341:Intercellular Signaling Peptides and Proteins; D059413:Intraabdominal Infections; D008297:Male; D010455:Peptides / Q000008:administration & dosage*; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000188:drug therapy*
chemical_list: D000927:Anticonvulsants; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; C056590:cortexin