title: Protective effect of triphala on radiation induced acute intestinal mucosal damage in Sprague Dawley rats.
abstract: Aim of the study was to determine protective effect of triphala on radiation-induced rectal mucosal damage. Male Sprague Dawley rats (30) were divided into 5 groups. Rats in group A were sham irradiated and rats in group B underwent only irradiation. Rats in group C were administered triphala 1 g/kg/day orally for 5 consecutive days before irradiation. Rats in group D and E were administered triphala 1 and 1.5 g/kg/day orally for 10 consecutive days, respectively. Rectal mucosal damage was induced by a single fraction of 12.5Gy gamma irradiation (Ir-192) on 5th day. All the rats were autopsied on 11th day and histological changes in surface epithelium, glands, and lamina propria were assessed. Proctitis showed significant improvement in surface epithelium (P < 0.024), glands (P < 0.000) and lamina propria (P < 0.002) in group E compared to group B. Rats in group E showed significantly less change in glands (P < 0.000) compared to rats in group D, All histological variables (surface epithelium, P < 0.001; glands, P < 0.000; lamina propria, P < 0.003) compared to rats in group C. In a Tukey-b test, group E had a significantly recovered grade for glands (P < 0.000) compared to groups B, C and D. Results of the present study showed that high-dose triphala improved radiation-induced damage of glands.
authors.affiliation: Department of Radiation Oncology, Korea University College of Medicine, 5th-ga Anam-dong, Seongbuk-gu, Seoul, Republic of Korea.
authors.forename: Won Sup
authors.initials: WS
authors.lastname: Yoon
authors.forename: Chul Yong
authors.initials: CY
authors.lastname: Kim
authors.forename: Dae Sik
authors.initials: DS
authors.lastname: Yang
authors.forename: Young Je
authors.initials: YJ
authors.lastname: Park
authors.forename: Won
authors.initials: W
authors.lastname: Park
authors.forename: Yong Chan
authors.initials: YC
authors.lastname: Ahn
authors.forename: Seok-Hyung
authors.initials: SH
authors.lastname: Kim
authors.forename: Ghee Young
authors.initials: GY
authors.lastname: Kwon
mesh_terms: D000818:Animals; D005260:Female; D007413:Intestinal Mucosa / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D011833:Radiation Injuries, Experimental / Q000188:drug therapy / Q000473:pathology; D011837:Radiation-Protective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D012007:Rectum / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects
chemical_list: D010936:Plant Extracts; D011837:Radiation-Protective Agents; C520904:triphala