title: 1H chemical shift magnetic resonance imaging probes with high sensitivity for multiplex imaging.
abstract: Proton-based chemical shift imaging probes were encapsulated inside nano-carriers to increase the sensivitity of the reporters. Co-encapsulation with a relaxation agent results in improved sensitivity and suppresses background signals. Simultaneous imaging of different chemical shift reporters allows multiplexed detection.
authors.affiliation: A.A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School 149, 13th Street, Suite 2301, Charlestown, MA 02129, USA.
authors.forename: Yan
authors.initials: Y
authors.lastname: Yang
authors.forename: Daniel T
authors.initials: DT
authors.lastname: Schühle
authors.forename: Guangping
authors.initials: G
authors.lastname: Dai
authors.forename: Jamu K
authors.initials: JK
authors.lastname: Alford
authors.forename: Peter
authors.initials: P
authors.lastname: Caravan
mesh_terms: D008081:Liposomes / Q000737:chemistry; D008279:Magnetic Resonance Imaging / Q000379:methods*; D015335:Molecular Probes; D011522:Protons; D059629:Signal-To-Noise Ratio; D013535:Suspensions; D013997:Time Factors
chemical_list: D008081:Liposomes; D015335:Molecular Probes; D011522:Protons; D013535:Suspensions