title: In vitro activities of clindamycin, imipenem, metronidazole, and piperacillin-tazobactam against susceptible and resistant isolates of Bacteroides fragilis evaluated by kill kinetics.
abstract: The aim of the present study was to investigate the activities of clindamycin, imipenem, metronidazole, and piperacillin-tazobactam against 12 Bacteroides fragilis isolates (resistant and susceptible strains) by kill kinetics over 24 h. In contrast to the other antimicrobial agents, clindamycin did not affect strains with MICs of >8.0 μg/ml. For those strains with MICs of ≤ 8.0 μg/ml, all employed antibiotics except clindamycin showed nearly bactericidal activity. Metronidazole proved to be the most active antimicrobial agent.
authors.affiliation: Institute for Medical Microbiology and Epidemiology of Infectious Diseases, University of Leipzig, Leipzig, Germany. reiner.schaumann@medizin
authors.forename: Reiner
authors.initials: R
authors.lastname: Schaumann
authors.forename: Matthias
authors.initials: M
authors.lastname: Funke
authors.forename: Eva
authors.initials: E
authors.lastname: Janssen
authors.forename: Arne C
authors.initials: AC
authors.lastname: Rodloff
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D001441:Bacteroides fragilis / Q000187:drug effects*; D002981:Clindamycin / Q000494:pharmacology*; D015378:Imipenem / Q000494:pharmacology*; D008795:Metronidazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010397:Penicillanic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D010878:Piperacillin / Q000494:pharmacology*; D000078142:Tazobactam
chemical_list: D000890:Anti-Infective Agents; D008795:Metronidazole; D002981:Clindamycin; D015378:Imipenem; D010397:Penicillanic Acid; D000078142:Tazobactam; D010878:Piperacillin