title: The effect of prednisone treatment on the half-life of intravenous hydrocortisone.
abstract: 1 The half-life of hydrocortisone (cortisol) has been measured in six patients before and after a three-week course of prednisone given for asthma. 2 There was considerable variation in peak plasma level of cortisol both within and between patients, but on both occasions the plasma half-lives were the same. 3 It was concluded that short courses of prednisone have no effect on the handling of hydrocortisone.
authors.affiliation: Asthma Research Concil Clinical Pharmacology Unit, Departmet of Medicine, Cardiothoracic Institute, Fulham Road, London.
authors.forename: G M
authors.initials: GM
authors.lastname: Shenfield
authors.forename: J W
authors.initials: JW
authors.lastname: Paterson
authors.forename: J F
authors.initials: JF
authors.lastname: Costello
authors.forename: O
authors.initials: O
authors.lastname: Ijaduola