title: Electrophysiological studies in American Quarter horses with neuroaxonal dystrophy.
abstract: OBJECTIVE
  Neuroaxonal dystrophy (NAD) is a disease characterized by the sudden onset of neurologic signs in horses ranging from 4 to 36 months of age. Equine degenerative myeloencephalopathy (EDM), a disease that has been associated with low vitamin E concentrations, is considered a more advanced form of NAD. The objective of this report is to describe the electrophysiological features of NAD/EDM in American Quarter horses (QHs). HORSES: Six NAD/EDM-affected QHs and six unaffected QHs were evaluated by ophthalmic examination and electroretinography. Five of the NAD/EDM-affected QH and five unaffected QHs were also evaluated by electroencephalography (EEG).
  
  
  RESULTS
  Ophthalmic examination, ERGs, and EEGs were unremarkable in NAD/EDM cases.
  
  
  CONCLUSIONS
  Neuroaxonal dystrophy/EDM does not appear to cause clinical signs of ocular disease or functional ERG/EEG deficits in QHs.
authors.affiliation: Population Health and Reproduction, University of California, Davis, CA 95616, USA. cjfinno@ucdavis.edu
authors.forename: Carrie J
authors.initials: CJ
authors.lastname: Finno
authors.forename: Monica
authors.initials: M
authors.lastname: Aleman
authors.forename: Ron
authors.initials: R
authors.lastname: Ofri
authors.forename: Steven R
authors.initials: SR
authors.lastname: Hollingsworth
authors.forename: John E
authors.initials: JE
authors.lastname: Madigan
authors.forename: Laramie
authors.initials: L
authors.lastname: Winfield
authors.forename: Danika L
authors.initials: DL
authors.lastname: Bannasch
mesh_terms: D000818:Animals; D004569:Electroencephalography / Q000662:veterinary*; D004596:Electroretinography / Q000379:methods / Q000662:veterinary*; D005260:Female; D006734:Horse Diseases / Q000503:physiopathology*; D006736:Horses; D008297:Male; D019150:Neuroaxonal Dystrophies / Q000503:physiopathology / Q000662:veterinary*; D014810:Vitamin E / Q000097:blood
chemical_list: D014810:Vitamin E