title: Accumulation and depletion kinetics of erythromycin in rainbow trout (Oncorhynchus mykiss).
abstract: Erythromycin is an antimicrobial agent recommended for the control and treatment of diseases caused by gram-positive bacteria. Few studies, however, have determined the metabolic and pharmacokinetic aspects of this antimicrobial agent in fish. The aim of the present study, therefore, was to determine the accumulation and depletion time of erythromycin after administration of medicated feed containing 52 mg kg(-1) body weight day(-1) for 8 days in rainbow trout (Oncorhynchus mykiss). Results were analyzed following the European Agency for Evaluation of Medicinal Products guidelines. We measured a withdrawal time of 187°C-day (°C-day=water temperature×days), lower than the value (500°C-day) recommended by Council Directive 2004/28/EC for veterinary medicinal products. Our results provide data to establish therapeutic regimens for the use of erythromycin in aquaculture.
authors.affiliation: Laboratory of Fish Pathology, Universidad de Zaragoza, c/Miguel Servet 177, 50013 Zaragoza, Spain.
authors.forename: Daniel
authors.initials: D
authors.lastname: Vendrell
authors.forename: Lidia
authors.initials: L
authors.lastname: Serarols
authors.forename: José Luis
authors.initials: JL
authors.lastname: Balcázar
authors.forename: Ignacio
authors.initials: I
authors.lastname: de Blas
authors.forename: Olivia
authors.initials: O
authors.lastname: Gironés
authors.forename: José Luis
authors.initials: JL
authors.lastname: Múzquiz
authors.forename: Imanol
authors.initials: I
authors.lastname: Ruiz-Zarzuela
mesh_terms: D000821:Animal Feed; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000032:analysis / Q000097:blood / Q000493:pharmacokinetics*; D017756:Aquaculture; D002851:Chromatography, High Pressure Liquid; D004350:Drug Residues / Q000032:analysis / Q000493:pharmacokinetics*; D004917:Erythromycin / Q000008:administration & dosage / Q000032:analysis / Q000097:blood / Q000493:pharmacokinetics*; D008460:Meat / Q000032:analysis; D018482:Muscle, Skeletal / Q000737:chemistry / Q000378:metabolism; D017686:Oncorhynchus mykiss / Q000378:metabolism*; D021241:Spectrometry, Mass, Electrospray Ionization; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D004917:Erythromycin