title: Chemical constituents and bioactivities of the plants of genus Flemingia Roxb. et Ait. (Leguminosae).
abstract: The genus Flemingia Roxb. et Ait. (Leguminosae) has been used for disease prevention and therapy in China since ancient times. So the material basis of the pharmacological activity in the genus Flemingia should be clear for how to use this kind of traditional Chinese medicines more reasonably in pharmacology. Therefore, this review gives an account of the current knowledge on the chemical constituents, biological activities and pharmacological properties of the plants of the genus. Several different classes of compounds were previously isolated, which the main groups are flavones, particularly prenylated flavones, and triterpenes accompanied with sterols, anthraquinones, and others. The names and structures of the chemical constituents are given in this review. In addition, the pharmacological effects of the extracts and individual compounds (mainly for flavones) derived from the genus plants have been found, including neuroprotection, anti-inflammation, anti-oxidation, cytotoxicity, hormone-like effects, antimicrobial activities, and so on.
authors.affiliation: Department of Food Science, Henan University of Technology, Lianhua Street, Gaoxin District, Zhengzhou 450001, Henan, China. lixian78101@163.com
authors.forename: Hua
authors.initials: H
authors.lastname: Li
authors.forename: Fengyan
authors.initials: F
authors.lastname: Zhai
authors.forename: Zhongdong
authors.initials: Z
authors.lastname: Liu
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000494:pharmacology*; D007887:Fabaceae / Q000737:chemistry*; D047309:Flavones / Q000737:chemistry* / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects; D006801:Humans; D009181:Mycoses / Q000188:drug therapy; D009369:Neoplasms / Q000188:drug therapy
chemical_list: D000890:Anti-Infective Agents; D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D047309:Flavones