title: PCOS and peripheral AMH levels in relation to FSH receptor gene single nucleotide polymorphisms.
abstract: OBJECTIVE
  To determine if an association exists between the follicle-stimulating hormone receptor (FSHR) gene p.Asn680Ser polymorphism and polycystic ovary syndrome (PCOS) or with high anti-mullerian hormone (AMH) levels without PCOS.
  
  
  METHODS
  Fifty-eight women with PCOS, 24 women with high AMH (>44.5 pmol/L) without PCOS and 80 healthy ethnically matched female controls.
  
  
  METHODS
  Prevalence of the FSHR p.Asn680Ser polymorphism, baseline serum AMH levels and response to ovulation induction with clomiphene citrate.
  
  
  RESULTS
  The frequency of FSHR p.Asn680Ser genotypes were not significantly different between PCOS patients, patients with high AMH without PCOS and controls (p = 0.88). Of the women with PCOS, 34/58 were on clomiphene citrate treatment and 12/34 were resistant. There was no association between sensitivity or resistance to clomiphene and p.Asn680Ser genotypes (p = 0.38).
  
  
  CONCLUSIONS
  There is no evidence that FSHR p.Asn680Ser genotypes are associated with PCOS, high AMH levels or response to clomiphene citrate.
authors.affiliation: Department of Reproductive Medicine, St.Mary's Hospital, Manchester, UK.
authors.forename: Lamiya
authors.initials: L
authors.lastname: Mohiyiddeen
authors.forename: Serena
authors.initials: S
authors.lastname: Salim
authors.forename: Betselot
authors.initials: B
authors.lastname: Mulugeta
authors.forename: Helen
authors.initials: H
authors.lastname: McBurney
authors.forename: William G
authors.initials: WG
authors.lastname: Newman
authors.forename: Phil
authors.initials: P
authors.lastname: Pemberton
authors.forename: Luciano G
authors.initials: LG
authors.lastname: Nardo
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D010865:Pilot Projects; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011446:Prospective Studies; D011962:Receptors, FSH / Q000235:genetics*
chemical_list: D011962:Receptors, FSH; D054304:Anti-Mullerian Hormone