title: A massive transfusion protocol incorporating a higher FFP/RBC ratio is associated with decreased use of recombinant activated factor VII in trauma patients.
abstract: We implemented a protocol incorporating a higher fresh frozen plasma (FFP)/RBC ratio for the management of trauma patients requiring massive transfusion in 2007. This study aims to identify issues that affected the effective deployment of the massive transfusion protocol (MTP) and compare outcome variables with a historic cohort. Data from 49 trauma patients who received at least 10 units of packed RBCs within 24 hours were analyzed and compared with a historic massively transfused cohort who had received recombinant activated factor VII (rFVIIa). Of the patients, 28 received an FFP/RBC ratio of 1:1 to 1:2; 12 received a lower ratio of 1:2 to 1:4; 3 received more than 1:1 and 6 had less than 1:4. Compared with the historic cohort, the 1:1-1:2 group received significantly fewer blood components and did not require rescue rFVIIa. An MTP incorporating a higher FFP/RBC ratio of 1:1 to 1:2 is associated with decreased use of blood components and may obviate the need for rFVII.
authors.affiliation: Dept of Pathology and Laboratory Medicine, Boston University Medical Center, MA 02118, USA.
authors.forename: Josenia N M
authors.initials: JN
authors.lastname: Tan
authors.forename: Peter A
authors.initials: PA
authors.lastname: Burke
authors.forename: Suresh K
authors.initials: SK
authors.lastname: Agarwal
authors.forename: Nelson
authors.initials: N
authors.lastname: Mantilla-Rey
authors.forename: Karen
authors.initials: K
authors.lastname: Quillen
mesh_terms: D000328:Adult; D001803:Blood Transfusion / Q000379:methods*; D015942:Factor VIIa / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010949:Plasma; D016896:Treatment Outcome; D014947:Wounds and Injuries / Q000628:therapy*
chemical_list: D015942:Factor VIIa