title: Endovascular stent provides more effective early relief of SVC obstruction compared to balloon angioplasty.
abstract: OBJECTIVE
  To determine whether superior vena cava (SVC) stent implantation is superior to balloon angioplasty for relieving SVC stenosis.
  
  
  BACKGROUND
  SVC stent and balloon dilation have been used as treatment for SVC stenosis. Although safe and effective, outcome data comparing the two methods are limited.
  
  
  METHODS
  A Pediatric Cardiac Care Consortium review identified SVC stenosis. Patients who required SVC intervention were divided into two subgroups-balloon dilation (Group A) and stent implantation (Group B). Logistic regression and the log-rank test were used to test the need for re-intervention within 6 months after the initial procedure.
  
  
  RESULTS
  SVC intervention was performed on 210/637 patients with SVC stenosis (33%). There were 108/210 (51%) patients with balloon dilation (Group A) and 102/210 (49%) with stent implantation (Group B). Re-intervention within 6 months of the initial intervention was more common in Group A compared to Group B [Group A = 31/40 (77.5%); Group B = 5/22 (22.7%)]. The odds-ratio for re-intervention within 6 months of the initial procedure for balloon vs. stent, is 7.3 [95% CI: (2.91, 22.3), P < 0.0001]. In addition, during the first 6 months after an intervention for SVC stenosis the proportion of patients with stent implantation that remained free of re-intervention was significantly higher than after balloon angioplasty (log-rank test, P < 0.0001). Neither age nor weight was significantly associated with the need for re-intervention.
  
  
  CONCLUSIONS
  SVC stent implantation is more effective than angioplasty in relief of SVC obstruction. Weight and age are not risk factors for early re-intervention.
authors.affiliation: Division of Pediatric Cardiology, Department of Pediatrics, University of Minnesota Amplatz Children's Hospital, Minneapolis, Minnesota.
authors.forename: Osamah
authors.initials: O
authors.lastname: Aldoss
authors.forename: Nofil
authors.initials: N
authors.lastname: Arain
authors.forename: Jeremiah
authors.initials: J
authors.lastname: Menk
authors.forename: Lazaros
authors.initials: L
authors.lastname: Kochilas
authors.forename: Daniel
authors.initials: D
authors.lastname: Gruenstein
mesh_terms: D000293:Adolescent; D000328:Adult; D000792:Angiography; D000800:Angioplasty, Balloon / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D057510:Endovascular Procedures / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012189:Retrospective Studies; D015607:Stents; D013479:Superior Vena Cava Syndrome / Q000175:diagnosis / Q000601:surgery*; D013997:Time Factors; D016896:Treatment Outcome; D055815:Young Adult