title: Yohimbine use for physical enhancement and its potential toxicity.
abstract: Yohimbine is a naturally sourced pharmacological agent, which produces hyperadrenergic physiological effects. In excess doses, it may typically cause agitation, anxiety, hypertension, and tachycardia. There is no conclusive evidence for this drug to be of benefit in bodybuilding, exercise tolerance, physical performance, or desirable alterations of body mass. Although tolerated generally well in low doses, the potential for dose-dependent toxicity should be recognized.
authors.affiliation: Department of Pathology and Laboratory Medicine, Faculty of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada. ncimolai@interchange.ubc.ca
authors.forename: Nevio
authors.initials: N
authors.lastname: Cimolai
authors.forename: Tomas
authors.initials: T
authors.lastname: Cimolai
mesh_terms: D018663:Adrenergic Agents / Q000009:adverse effects / Q000494:pharmacology*; D000328:Adult; D000818:Animals; D015444:Exercise; D005260:Female; D006801:Humans; D008297:Male; D010809:Physical Fitness; D010936:Plant Extracts / Q000009:adverse effects / Q000494:pharmacology*; D014891:Weight Lifting; D015431:Weight Loss / Q000187:drug effects; D015016:Yohimbine / Q000009:adverse effects / Q000494:pharmacology*; D055815:Young Adult
chemical_list: D018663:Adrenergic Agents; D010936:Plant Extracts; D015016:Yohimbine