title: Conservative surgery in patients with malignant ovarian germ cell tumours.
abstract: Conservative surgery with adjuvant chemotherapy has made the preservation of fertility even in patient with advanced disease. The increase in cure rate has shifted to research for the long term menstrual reproductive and gynecologic outcome in these patients. The current study is retrospective for 25 cases of ovarian malignant germ cell tumor from January 2006 to January 2011, at El Hussian and Sayed Galal University Hospitals. The uterus and contralateral ovary were retained to preserve ovarian function with or without chemotherapy, followed up for two years. The mean age of most patients ranged from 15-28 years (average 21.5 years). According to International Federation of Gynecology and Obstetrics, the histological subtypes were ten dysgerminoma (40%). Five immature teratoma (20%), three endodermal sinus tumor (12%), four mixed germ cell tumor (16%) three embryonic cell tumours (12%). Stage I: tumors 15 cases (60%), Stage II: tumors one case (4%), Stage III tumors 6 cases (24%), Stage IV tumors 3 cases (12%). Adjuvant chemotherapy was administered to 15 cases 60% and followed up for two years. There were two recurrences, one died at 7th day postoperative of massive pulmonary embolism with past history of D.V.T, five healthy live births in the chemotherapy group without birth defects, and one infertility case 4%.
authors.affiliation: Department of Oncology, Faculty of Medicine, Al Azhar University, Cairo, Egypt.
authors.forename: Magedy Mohamad
authors.initials: MM
authors.lastname: Al-Sayed
authors.forename: Ali Abd El-Fattah
authors.initials: AA
authors.lastname: El-Sayed
authors.forename: Taher Mostafa
authors.initials: TM
authors.lastname: El-Barbary
authors.forename: Osama
authors.initials: O
authors.lastname: Hamad
mesh_terms: D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D005260:Female; D005298:Fertility; D006801:Humans; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D009373:Neoplasms, Germ Cell and Embryonal / Q000188:drug therapy / Q000601:surgery*; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000601:surgery*; D010052:Ovariectomy / Q000379:methods*; D010053:Ovary / Q000502:physiology; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D000970:Antineoplastic Agents