title: Regulation of GPCR trafficking by RAMPs.
abstract: AM and CGRP receptors undergo differential intracellular receptor trafficking upon ligand stimulation. Intracellular trafficking of CLR/RAMP receptor complexes is regulated by posttranslational modifications and protein-protein interactions that differ for each cell type. Recent evidence is accumulating to suggest that the RAMP isoform in complex with CLR may play a role in determining the intracellular trafficking and fate of ligand-stimulated receptor complexes. In this chapter, we will review the current literature on mechanisms of regulating receptor trafficking and roles that have been demonstrated for RAMPs in this regulation.
authors.affiliation: Department of Physiology, Michigan State University, East Lansing, MI, USA. jennifer.m.bomberger@dartmouth.edu
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Bomberger
authors.forename: Narayanan
authors.initials: N
authors.lastname: Parameswaran
authors.forename: William S
authors.initials: WS
authors.lastname: Spielman
mesh_terms: D006801:Humans; D021381:Protein Transport; D059748:Proteolysis; D058261:Receptor Activity-Modifying Proteins / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*
chemical_list: D058261:Receptor Activity-Modifying Proteins; D043562:Receptors, G-Protein-Coupled