title: Administration of vincristine in a patient with Machado-Joseph disease.
abstract: Chemotherapy-induced peripheral neurotoxicity is a major problem because it represents the dose-limiting side effect of a significant number of antineoplastic drugs, such as vinca alkaloids. Hereditary neuropathies usually predispose to severe vincristine neurotoxicity. Here, we report the case of a 56-year-old man with Machado-Joseph disease, also known as spinocerebellar ataxia type 3, treated with a vinca alkaloid without exacerbation of neurological symptoms.
authors.affiliation: Department of Medicine, Haematology and Clinical Immunology, University of Padua School of Medicine, Padua, Italy.
authors.forename: Anna
authors.initials: A
authors.lastname: Colpo
authors.forename: Frederick H
authors.initials: FH
authors.lastname: Wilson
authors.forename: Valentina
authors.initials: V
authors.lastname: Nardi
authors.forename: Ephraim
authors.initials: E
authors.lastname: Hochberg
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage*; D006801:Humans; D017827:Machado-Joseph Disease / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D011379:Prognosis; D014057:Tomography, X-Ray Computed; D014750:Vincristine / Q000008:administration & dosage*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D014750:Vincristine