title: Combined treatment of odontogenic keratocysts: initial marsupialization and successive enucleation with peripheral ostectomy plus Carnoy's solution application. A five-year follow-up experience.
abstract: OBJECTIVE
  The odontogenic keratocyst (KCOT) is a locally aggressive, cystic jaw lesion with a high growth potential and a propensity for recurrence. Considering its neoplastic features, treatments of keratocysts are required and they are generally classified as conservative or aggressive. However, although in literature there are several studies, the choice of treatment strategies remains controversial. We report a two-stage protocol based on initial marsupialization and successive enucleation.
  
  
  METHODS
  Three cases of large KCOTs have been treated by initial marsupialization and, after a mean period of six months, successive enucleation with peripheral ostectomy and application of Carnoy's solution was performed.
  
  
  RESULTS
  All patients were instructed in daily irrigation using chlorhexidine 0.2% during the period of marsupialization. After enucleation, good healing was obtained in all cases and from two up to five years of follow-up, there is no evidence of recurrence.
  
  
  CONCLUSIONS
  Two-stage surgical treatment protocol of keratocyst leads to complete healing, preservation of important anatomical structures and absence of recurrence.
authors.affiliation: Department of Oral Surgery, University of Milan Dental Clinic, Fondazione IRCCS Ca'Granda Ospedale Maggiore Policlinico, Milan, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Rossi
authors.forename: A E
authors.initials: AE
authors.lastname: Borgonovo
authors.forename: V
authors.initials: V
authors.lastname: Vavassori
authors.forename: P P
authors.initials: PP
authors.lastname: Poli
authors.forename: F
authors.initials: F
authors.lastname: Santoro
mesh_terms: D019342:Acetic Acid / Q000627:therapeutic use*; D000328:Adult; D002725:Chloroform / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D000431:Ethanol / Q000627:therapeutic use*; D005260:Female; D005404:Fixatives; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008339:Mandibular Neoplasms / Q000188:drug therapy / Q000601:surgery*; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D009807:Odontogenic Cysts / Q000188:drug therapy / Q000601:surgery*; D009808:Odontogenic Tumors / Q000188:drug therapy / Q000601:surgery*; D019647:Oral Surgical Procedures; D011489:Protein Denaturation; D013188:Sri Lanka / Q000208:ethnology
chemical_list: C033474:Carnoy's solution; D005404:Fixatives; D000431:Ethanol; D002725:Chloroform; D019342:Acetic Acid