title: IKK biology.
abstract: The inhibitor of nuclear factor-κB (IκB) kinase (IKK) complex is the master regulator of the NF-κB signaling pathway. The activation of the IKK complex is a tightly regulated, highly stimulus-specific, and target-specific event that is essential for the plethora of functions attributed to NF-κB. More recently, NF-κB-independent roles of IKK members have brought increased complexity to its biological function. This review highlights some of the major advances in the studies of the process of IKK activation and the biological roles of IKK family members, with a focus on NF-κB-independent functions. Understanding these complex processes is essential for targeting IKK for therapeutics.
authors.affiliation: Laboratory of Genetics, The Salk Institute, La Jolla, CA 92037, USA.
authors.forename: Fei
authors.initials: F
authors.lastname: Liu
authors.forename: Yifeng
authors.initials: Y
authors.lastname: Xia
authors.forename: Aaron S
authors.initials: AS
authors.lastname: Parker
authors.forename: Inder M
authors.initials: IM
authors.lastname: Verma
mesh_terms: D000818:Animals; D004789:Enzyme Activation; D006801:Humans; D051550:I-kappa B Kinase / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D047428:Protein Kinase Inhibitors / Q000737:chemistry / Q000494:pharmacology; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D047428:Protein Kinase Inhibitors; D051550:I-kappa B Kinase