title: Efficacy of cytidine-5'-diphosp-bocholine combined with compound anisodine in the treatment of early optic nerve contusion.
abstract: OBJECTIVE
  To investigate the efficacy of anisodine combined with cytidine-5'-diphosp-bocholine (citicoline) in the treatment of early optic nerve contusion.
  
  
  METHODS
  A total of 33 subjects eligible for inclusion were selected from 105 patients clinically diagnosed with optic nerve contusion. These patients were subsequently divided into the control group (n=16) and the intervention group (n=17). In the control group, the participants received therapy consisting of glucocorticoids, mannitol, vasodilators and vitamin B. The patients in the intervention group additionally received anisodine in combination with citicoline. The visual acuity was graded on a scale from 0 to 8.
  
  
  RESULTS
  Prior to treatment, the 25th, 50th and 75th percentiles of visual acuity grade were 3, 4 and 6.75 for the controls, and 3, 4 and 6.5 for the patients in the intervention group. (P=0.97). After treatment, the 25th, 50th and 75th percentiles of visual acuity grade were 4, 6 and 7.75 in the control group, and 7, 7 and 8 in the intervention group. (P=0.046). A significant difference was observed in both control (P=0.005) and intervention groups (P=0.001) when comparing presenting visual acuity before and after treatment.
  
  
  CONCLUSIONS
  The combination of anisodine and citicoline with standard steroid and mannitol therapy appears to be effective in the treatment of early optic nerve contusion.
authors.affiliation: Department of Ophthalmology, People's Hospital of Lianjiang, Lianjiang, China. wangwenhua741204@163.com
authors.forename: Wenhua
authors.initials: W
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Huang
authors.forename: Jianli
authors.initials: J
authors.lastname: Zhang
authors.forename: Jiahai
authors.initials: J
authors.lastname: Jiang
authors.forename: Jinxiu
authors.initials: J
authors.lastname: Huang
mesh_terms: D003288:Contusions / Q000188:drug therapy*; D003566:Cytidine Diphosphate Choline / Q000627:therapeutic use*; D004359:Drug Therapy, Combination / Q000379:methods; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008353:Mannitol / Q000627:therapeutic use; D008875:Middle Aged; D020221:Optic Nerve Injuries / Q000188:drug therapy*; D012602:Scopolamine Derivatives / Q000627:therapeutic use*; D016896:Treatment Outcome; D014792:Visual Acuity / Q000187:drug effects / Q000502:physiology
chemical_list: D005938:Glucocorticoids; D012602:Scopolamine Derivatives; D008353:Mannitol; D003566:Cytidine Diphosphate Choline; C012183:anisodine