title: Small- and wide-angle X-ray scattering (SWAXS) for quantification of aspirin content in a binary powder mixture.
abstract: This article presents a novel application of small and wide angle X-ray scattering (SWAXS) in the assessment of aspirin and lactose content in a binary pharmaceutical powder formulation. It is shown that the content correlates with the intensity of the SAXS signal and the intensity of polymorph fingerprints in the WAXS spectra that are collected from the same samples. Because the polymorph WAXS fingerprints and the SAXS signal are two independent characteristics of the same sample, simultaneous SWAXS analysis provides the basis for a dual independent assessment of the same contents.
authors.affiliation: Research Center Pharmaceutical Engineering GmbH, A-8010 Graz, Austria.
authors.forename: A
authors.initials: A
authors.lastname: Hodzic
authors.forename: M
authors.initials: M
authors.lastname: Llusa
authors.forename: S D
authors.initials: SD
authors.lastname: Fraser
authors.forename: O
authors.initials: O
authors.lastname: Scheibelhofer
authors.forename: D M
authors.initials: DM
authors.lastname: Koller
authors.forename: F
authors.initials: F
authors.lastname: Reiter
authors.forename: P
authors.initials: P
authors.lastname: Laggner
authors.forename: J G
authors.initials: JG
authors.lastname: Khinast
mesh_terms: D001241:Aspirin / Q000737:chemistry*; D007785:Lactose / Q000737:chemistry; D010316:Particle Size; D011208:Powders / Q000737:chemistry*; D053838:Scattering, Small Angle; D014961:X-Ray Diffraction / Q000379:methods*; D014965:X-Rays
chemical_list: D011208:Powders; D007785:Lactose; D001241:Aspirin