title: Lack of association of polymorphism in miRNA-196a2 with Parkinson's disease risk in a Chinese population.
abstract: MicroRNAs (miRNAs) are a new class of non-protein coding RNA molecules, which participate in diverse biological pathways. We hypothesized that miRNA-196a2 polymorphism is associated with the risk of Parkinson's disease (PD) in a Chinese population. In a case-control study of 549 PD patients and 736 control subjects frequency matched by age and gender, we genotyped the single-nucleotide polymorphism (SNP) rs11614913 (T>C) in miRNA-196a2, whose target mRNA was alpha-synuclein, and assessed its association with risk of PD by TaqMan Genotyping method. No association was found for the miR-196a2 rs11614913 CT/CC genotype (odds ratio (OR), 0.879, 95% confidence interval (CI), 0.681-1.135 for CT genotype; OR, 1.085, 95% CI, 0.793-1.484 for CC genotype) with risk of PD, compared with the TT genotype. These results suggest that SNP rs11614913 in miRNA-196a2 may not contribute to the susceptibility to PD.
authors.affiliation: Department of Geriatric, Nanjing Medical University First Affiliated Hospital, No. 300, Guangzhou Road, Nanjing, Jiangsu Province 210029, PR China.
authors.forename: Ding
authors.initials: D
authors.lastname: Haixia
authors.forename: Dong
authors.initials: D
authors.lastname: Hairong
authors.forename: Chen
authors.initials: C
authors.lastname: Weixian
authors.forename: Ye
authors.initials: Y
authors.lastname: Min
authors.forename: Wang
authors.initials: W
authors.lastname: Qiang
authors.forename: Xiao
authors.initials: X
authors.lastname: Hang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D002681:China; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D012333:RNA, Messenger; D012306:Risk
chemical_list: C542543:MIRN196 microRNA, human; D035683:MicroRNAs; D012333:RNA, Messenger