title: Free-radical degradation of high-molar-mass hyaluronan induced by ascorbate plus cupric ions: testing of stobadine and its two derivatives in function as antioxidants.
abstract: Stobadine·2HCl and its two hydrophilic derivatives SM1dM9dM10·2HCl and SME1i-ProC2·HCl were tested in the function of antioxidants on hyaluronan (HA) degradation induced by the Weissberger oxidative system [ascorbate plus Cu(II)]. As a primary method, rotational viscometry was applied, where the substance tested was added before or 1 h after the initiation of HA degradation. The most effective scavengers of •OH and peroxy-type radicals were recorded to be stobadine·2HCl and SME1i-ProC2·HCl, respectively. The most effective scavenger, determined by applying the ABTS assay, was stobadine·2HCl.
authors.affiliation: Institute of Experimental Pharmacology and Toxicology, Slovak Academy of Sciences, Bratislava, Slovak Republic.
authors.forename: Lubica
authors.initials: L
authors.lastname: Surovcikova-Machova
authors.forename: Katarina
authors.initials: K
authors.lastname: Valachova
authors.forename: Maria
authors.initials: M
authors.lastname: Banasova
authors.forename: Vladimir
authors.initials: V
authors.lastname: Snirc
authors.forename: Elena
authors.initials: E
authors.lastname: Priesolova
authors.forename: Milan
authors.initials: M
authors.lastname: Nagy
authors.forename: Ivo
authors.initials: I
authors.lastname: Juranek
authors.forename: Ladislav
authors.initials: L
authors.lastname: Soltes
mesh_terms: D000975:Antioxidants / Q000737:chemistry*; D001205:Ascorbic Acid / Q000737:chemistry*; D002243:Carbolines / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D005609:Free Radicals / Q000737:chemistry; D006820:Hyaluronic Acid / Q000737:chemistry*; D008970:Molecular Weight
chemical_list: D000975:Antioxidants; D002243:Carbolines; D005609:Free Radicals; D003300:Copper; D006820:Hyaluronic Acid; D001205:Ascorbic Acid; C100106:dicarbine