title: Chitosan-based gastroretentive floating drug delivery technology: an updated review.
abstract: BACKGROUND
  Gastroretentive floating drug delivery systems have emerged as efficient approaches for enhancing the bioavailability and controlled delivery of various therapeutic agents. Significant advancements exploiting chitosan have been made worldwide, in order to investigate these systems according to patient requirements, both in terms of therapeutic efficacy as well as patient compliance. Such systems precisely control the release rate of the target drug to a specific site, which facilitates an enormous impact on health care.
  
  
  METHODS
  Different novel strategies have been undertaken for the development of various gastric floating dosage forms utilizing chitosan as a promising excipient. The present paper is an earnest attempt to provide new insights on various physicochemical and biological characteristics of chitosan, along with its potential applications in a wide array of biomedical approaches. Numerous and significant research findings in the vistas of chitosan-based gastroretentive floating drug delivery technology are also discussed.
  
  
  CONCLUSIONS
  Chitosan has been considered as a unique and efficacious agent possessing a myriad spectrum of desired characteristics. It is emphasized that recent scientific advancements in the use of this excipient as a carrier will yield new generation gastroretentive drug delivery systems, with better pharmacotherapeutic interventions. Further studies are required to unveil the hidden beneficial properties of chitosan and its derivatives, to obtain newer delivery systems which may hold tremendous prospects in the near future.
authors.affiliation: Kurukshetra University, Institute of Pharmaceutical Sciences, Kurukshetra-136119, India.
authors.forename: Rakesh
authors.initials: R
authors.lastname: Pahwa
authors.forename: Nidhi
authors.initials: N
authors.lastname: Saini
authors.forename: Vipin
authors.initials: V
authors.lastname: Kumar
authors.forename: Kanchan
authors.initials: K
authors.lastname: Kohli
mesh_terms: D001682:Biological Availability; D002214:Capsules; D002626:Chemistry, Pharmaceutical; D048271:Chitosan / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics*; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics; D004337:Drug Carriers / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics*; D005079:Excipients / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics*; D005753:Gastric Mucosa / Q000378:metabolism; D006801:Humans; D007408:Intestinal Absorption; D015394:Molecular Structure; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D013607:Tablets
chemical_list: D002214:Capsules; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D005079:Excipients; D004364:Pharmaceutical Preparations; D013607:Tablets; D048271:Chitosan