title: Anxiety and predisposition to audiogenic epilepsy in rats of different genotypes.
abstract: We studied plus-maze behavior of inbred Krushinskii-Molodkina, Wistar, and black-hooded rats (originating from the Long-Evans outbred strain) differing by predisposition to audiogenic seizures. The severity of audiogenic seizures partially correlated with anxiety and negatively correlated with the total level of locomotor activity in the elevated plus-maze. The anxiety parameters in Krushinskii-Molodkina rats were evaluated after injection of anticonvulsant levetiracetam and anxiolytic afobazol. Levetiracetam and afobazol somewhat stimulated locomotor activity.
authors.affiliation: Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia. opera_ghost@inbox.ru
authors.forename: N M
authors.initials: NM
authors.lastname: Surina
authors.forename: T S
authors.initials: TS
authors.lastname: Kalinina
authors.forename: A V
authors.initials: AV
authors.lastname: Volkova
authors.forename: L A
authors.initials: LA
authors.lastname: Malikova
authors.forename: I I
authors.initials: II
authors.lastname: Poletaeva
authors.forename: K S
authors.initials: KS
authors.lastname: Rayevsky
authors.forename: I B
authors.initials: IB
authors.lastname: Fedotova
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000927:Anticonvulsants / Q000008:administration & dosage / Q000627:therapeutic use*; D001007:Anxiety / Q000150:complications / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology*; D001562:Benzimidazoles / Q000008:administration & dosage / Q000627:therapeutic use; D020195:Epilepsy, Reflex / Q000150:complications / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology*; D020022:Genetic Predisposition to Disease; D007274:Injections, Intraperitoneal; D000077287:Levetiracetam; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D009025:Morpholines / Q000008:administration & dosage / Q000627:therapeutic use; D009043:Motor Activity / Q000187:drug effects; D010889:Piracetam / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains; D020318:Rats, Long-Evans; D017208:Rats, Wistar; D012720:Severity of Illness Index
chemical_list: C410924:2-((2-morpholino)ethylthio)-5-ethoxybenzimidazole; D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D001562:Benzimidazoles; D009025:Morpholines; D000077287:Levetiracetam; D010889:Piracetam