title: The role of thrombomodulin lectin-like domain in inflammation.
abstract: Thrombomodulin (TM) is a cell surface glycoprotein which is widely expressed in a variety of cell types. It is a cofactor for thrombin binding that mediates protein C activation and inhibits thrombin activity. In addition to its anticoagulant activity, recent evidence has revealed that TM, especially its lectin-like domain, has potent anti-inflammatory function through a variety of molecular mechanisms. The lectin-like domain of TM plays an important role in suppressing inflammation independent of the TM anticoagulant activity. This article makes an extensive review of the role of TM in inflammation. The molecular targets of TM lectin-like domain have also been elucidated. Recombinant TM protein, especially the TM lectin-like domain may play a promising role in the management of sepsis, glomerulonephritis and arthritis. These data demonstrated the potential therapeutic role of TM in the treatment of inflammatory diseases.
authors.affiliation: Department of Internal Medicine, National Cheng Kung University Hospital and College of Medicine, Tainan, Taiwan.
authors.forename: Yi-Heng
authors.initials: YH
authors.lastname: Li
authors.forename: Cheng-Hsiang
authors.initials: CH
authors.lastname: Kuo
authors.forename: Guey-Yueh
authors.initials: GY
authors.lastname: Shi
authors.forename: Hua-Lin
authors.initials: HL
authors.lastname: Wu
mesh_terms: D001168:Arthritis / Q000188:drug therapy; D001777:Blood Coagulation; D005921:Glomerulonephritis / Q000188:drug therapy; D024243:HMGB1 Protein / Q000494:pharmacology; D006801:Humans; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism*; D011486:Protein C / Q000378:metabolism; D017434:Protein Structure, Tertiary / Q000235:genetics*; D018805:Sepsis / Q000188:drug therapy; D013917:Thrombin / Q000378:metabolism*; D018180:Thrombomodulin / Q000235:genetics / Q000378:metabolism* / Q000627:therapeutic use*
chemical_list: D024243:HMGB1 Protein; D011486:Protein C; C546931:THBD protein, human; D018180:Thrombomodulin; D013917:Thrombin