title: Models of the aging brain structure and individual decline.
abstract: The aging brain's structural development constitutes a spatiotemporal process that is accessible by MR-based computational morphometry. Here we introduce basic concepts and analytical approaches to quantify age-related differences and changes in neuroanatomical images of the human brain. The presented models first address the estimation of age trajectories, then we consider inter-individual variations of structural decline, using a repeated measures design. We concentrate our overview on preprocessed neuroanatomical images of the human brain to facilitate practical applications to diverse voxel- and surface-based structural markers. Together these methods afford analysis of aging brain structure in relation to behavioral, health, or cognitive parameters.
authors.affiliation: Structural Brain Mapping Group, Department of Psychiatry, Jena University Hospital Jena, Germany.
authors.forename: Gabriel
authors.initials: G
authors.lastname: Ziegler
authors.forename: Robert
authors.initials: R
authors.lastname: Dahnke
authors.forename: Christian
authors.initials: C
authors.lastname: Gaser