title: Effects on (neuro)developmental and behavioral outcome at 2 years of age of induced labor compared with expectant management in intrauterine growth-restricted infants: long-term outcomes of the DIGITAT trial.
abstract: OBJECTIVE
  We sought to study long-term (neuro)developmental and behavioral outcome of pregnancies complicated by intrauterine growth restriction at term in relation to induction of labor or an expectant management.
  
  
  METHODS
  Parents of 2-year-old children included in the Disproportionate Intrauterine Growth Intervention Trial at Term (DIGITAT) answered the Ages and Stages Questionnaire (ASQ) and Child Behavior Checklist (CBCL).
  
  
  RESULTS
  We approached 582 (89.5%) of 650 parents. The response rate was 50%. Of these children, 27% had an abnormal score on the ASQ and 13% on the CBCL. Results of the ASQ and the CBCL for the 2 policies were comparable. Low birthweight, positive Morbidity Assessment Index score, and admission to intermediate care increased the risk of an abnormal outcome of the ASQ. This effect was not seen for the CBCL.
  
  
  CONCLUSIONS
  In women with intrauterine growth restriction at term, neither a policy of induction of labor nor expectant management affect developmental and behavioral outcome when compared to expectant management.
authors.affiliation: Leiden University Medical Center, Leiden, The Netherlands. lvwyk@xs4all.nl
authors.forename: Linda
authors.initials: L
authors.lastname: van Wyk
authors.forename: Kim E
authors.initials: KE
authors.lastname: Boers
authors.forename: Joris A M
authors.initials: JA
authors.lastname: van der Post
authors.forename: Maria G
authors.initials: MG
authors.lastname: van Pampus
authors.forename: Aleid G
authors.initials: AG
authors.lastname: van Wassenaer
authors.forename: Anneloes L
authors.initials: AL
authors.lastname: van Baar
authors.forename: Marc E A
authors.initials: ME
authors.lastname: Spaanderdam
authors.forename: Jeroen H
authors.initials: JH
authors.lastname: Becker
authors.forename: Anneke
authors.initials: A
authors.lastname: Kwee
authors.forename: Johannes J
authors.initials: JJ
authors.lastname: Duvekot
authors.forename: Henk A
authors.initials: HA
authors.lastname: Bremer
authors.forename: Friso M C
authors.initials: FM
authors.lastname: Delemarre
authors.forename: Kitty W M
authors.initials: KW
authors.lastname: Bloemenkamp
authors.forename: Christianne J M
authors.initials: CJ
authors.lastname: de Groot
authors.forename: Christine
authors.initials: C
authors.lastname: Willekes
authors.forename: Frans J M E
authors.initials: FJ
authors.lastname: Roumen
authors.forename: Jan M M
authors.initials: JM
authors.lastname: van Lith
authors.forename: Ben W J
authors.initials: BW
authors.lastname: Mol
authors.forename: Saskia
authors.initials: S
authors.lastname: le Cessie
authors.forename: Sicco A
authors.initials: SA
authors.lastname: Scherjon
mesh_terms: D000328:Adult; D002653:Child Behavior Disorders / Q000175:diagnosis / Q000209:etiology*; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D005317:Fetal Growth Retardation; D005500:Follow-Up Studies; D006801:Humans; D007751:Labor, Induced; D016015:Logistic Models; D011247:Pregnancy; D011795:Surveys and Questionnaires; D047929:Term Birth; D057832:Watchful Waiting