title: Elimination half-life of intravenously administered equine cardiac troponin I in healthy ponies.
abstract: BACKGROUND
  To date, no information is available on the true biological elimination half-life (T(1/2) ) of cardiac troponin I (cTnI) in the equine species. Such data are required to better evaluate the optimal time to acquire the cTnI sample following acute myocardial injury.
  
  
  OBJECTIVE
  To determine the T(1/2) of equine cTnI.
  
  
  METHODS
  Four healthy ponies received i.v. injections of recombinant equine cTnI. Plasma cTnI concentrations were measured with a point-of-care cTnI analyser at multiple time points after injection. Standard pharmacokinetic analysis was performed to establish the T(1/2) of cTnI.
  
  
  RESULTS
  The average T(1/2) of cTnI was determined to be 0.47 h using a single rate elimination model.
  
  
  CONCLUSIONS
  The elimination of recombinant equine cTnI following i.v. administration is very rapid. Establishing the T(1/2 ) of troponin provides critical information in understanding the clinical application of this cardiac biomarker in equine practice.
authors.affiliation: Department of Clinical Sciences, College of Veterinary Medicine, Cornell University, New York, NY, USA. msk16@cornell.edu
authors.forename: M S
authors.initials: MS
authors.lastname: Kraus
authors.forename: B B
authors.initials: BB
authors.lastname: Kaufer
authors.forename: A
authors.initials: A
authors.lastname: Damiani
authors.forename: N
authors.initials: N
authors.lastname: Osterrieder
authors.forename: M
authors.initials: M
authors.lastname: Rishniw
authors.forename: W
authors.initials: W
authors.lastname: Schwark
authors.forename: A R
authors.initials: AR
authors.lastname: Gelzer
authors.forename: T J
authors.initials: TJ
authors.lastname: Divers
mesh_terms: D000818:Animals; D003001:Cloning, Molecular; D005260:Female; D006207:Half-Life; D006736:Horses / Q000097:blood* / Q000378:metabolism*; D008297:Male; D011994:Recombinant Proteins; D019210:Troponin I / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D011994:Recombinant Proteins; D019210:Troponin I