title: Effectiveness of the Novel Herbal Medicine, KIOM-MA, and Its Bioconversion Product, KIOM-MA128, on the Treatment of Atopic Dermatitis.
abstract: This study was conducted to determine if oral administration of the novel herbal medicine, KIOM-MA, and its Lactobacillus acidophilus-fermented product, KIOM-MA128, has therapeutic properties for the treatment of atopic dermatitis (AD). Using AD-induced BALB/c mice by Ovalbumin and aluminum hydroxide, the effectiveness of KIOM-MA and KIOM-MA128 on AD was evaluated. Oral administration of KIOM-MA and KIOM-MA128 reduced major clinical signs of AD including erythema/darkening, edema/papulation, excoriations, lichenification/prurigo, and dryness. Interestingly, KIOM-MA128 more significantly improved AD-related symptoms including decrease of IgE level in the plasma as well as reduction of scratching behavior, skin severity in the AD BALB/c model. HPLC analysis showed the significant changes in the constituent patterns between KIOM-MA and KIOM-MA128. Our results suggest that both KIOM-MA and KIOM-MA128 have potential for therapeutic reagent for the treatment of AD, and further, the efficacy is significantly enhanced by L. acidophilus fermentation via increases in its indicator molecule.
authors.affiliation: Center for Herbal Medicine Improvement Research, Korea Institute of Oriental Medicine (KIOM), 483 Expo-ro, Yuseong-gu, Daejeon 305-811, Republic of Korea.
authors.forename: Tae Ho
authors.initials: TH
authors.lastname: Chung
authors.forename: Tae Jin
authors.initials: TJ
authors.lastname: Kang
authors.forename: Won-Kyung
authors.initials: WK
authors.lastname: Cho
authors.forename: Ga Young
authors.initials: GY
authors.lastname: Im
authors.forename: Geum Seon
authors.initials: GS
authors.lastname: Lee
authors.forename: Min Cheol
authors.initials: MC
authors.lastname: Yang
authors.forename: Chang-Won
authors.initials: CW
authors.lastname: Cho
authors.forename: Jin Yeul
authors.initials: JY
authors.lastname: Ma