title: Reduction in size of renal angiomyolipoma after treatment with everolimus in lung transplantation due to lymphangioleiomyomatosis.
abstract: Lymphangioleiomyomatosis (LAM) is a rare disease characterized by abnormal proliferation of immature smooth muscle cells and cystic lung destruction, which determines the prognosis of the disease. The kidney angiomyolipomas are usually very common in this disease and are usually asymptomatic unless complications arise. In the absence of a curative treatment, recent publications show promising results in molecular therapy to prevent functional decline and to control the size of the angiomyolipomas. These therapies include mTOR complex inhibitors, especially sirolimus. We report a case of a patient diagnosed with LAM who underwent lung transplantation with reduction of renal angiomyolipoma size after treatment with the mTOR inhibitor everolimus.
authors.affiliation: Unidad de Gestión Clínica de Neumología, Hospital Universitario Reina Sofía, Córdoba, España. carlosbujalance@hotmail.com
authors.forename: Carlos
authors.initials: C
authors.lastname: Bujalance-Cabrera
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Vaquero-Barrios
authors.forename: Javier
authors.initials: J
authors.lastname: Redel-Montero
authors.forename: Laura
authors.initials: L
authors.lastname: Caballero-Ballesteros
authors.forename: Antonio
authors.initials: A
authors.lastname: Requejo-Jiménez
authors.forename: Francisco
authors.initials: F
authors.lastname: Santos-Luna
mesh_terms: D000328:Adult; D018207:Angiomyolipoma / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000068338:Everolimus; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000473:pathology*; D016040:Lung Transplantation; D018192:Lymphangioleiomyomatosis / Q000150:complications / Q000601:surgery*; D020123:Sirolimus / Q000031:analogs & derivatives* / Q000627:therapeutic use; D047368:Tumor Burden
chemical_list: D000970:Antineoplastic Agents; D000068338:Everolimus; D020123:Sirolimus