title: Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease.
abstract: Interleukin 10 (IL-10) is a cytokine with potent anti-inflammatory properties that plays a central role in limiting host immune response to pathogens, thereby preventing damage to the host and maintaining normal tissue homeostasis. Dysregulation of IL-10 is associated with enhanced immunopathology in response to infection as well as increased risk for development of many autoimmune diseases. Thus a fundamental understanding of IL-10 gene expression is critical for our comprehension of disease progression and resolution of host inflammatory response. In this review, we discuss modes of regulation of IL-10 gene expression in immune effector cell types, including signal transduction, epigenetics, promoter architecture, and post-transcriptional regulation, and how aberrant regulation contributes to immunopathology and disease progression.
authors.affiliation: Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA.
authors.forename: Shankar Subramanian
authors.initials: SS
authors.lastname: Iyer
authors.forename: Gehong
authors.initials: G
authors.lastname: Cheng
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D007249:Inflammation / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D016753:Interleukin-10 / Q000235:genetics / Q000276:immunology*; D015398:Signal Transduction; D014158:Transcription, Genetic
chemical_list: D016753:Interleukin-10