title: Protective effect of extract of chicken meat on restraint stress-induced liver damage in mice.
abstract: In this study, we investigated the protective effects of the extract of chicken meat (EC) on liver damage in mice caused by restraint stress. Our results showed that 18 h of restraint stress-induced liver damage was marked by an increase of plasma alanine aminotransferase (ALT) and aspartate aminotransferase(AST) levels. However, oral administration of EC (0.12 and 0.24 mL/10 g per day, 7 d) was found to reduce the increased plasma ALT and AST levels in stressed mice. Meanwhile, EC significantly decreased the contents of malondialdehyde and increased the activities of superoxide dismutase (SOD) and glutathione peroxidase (GPX) in plasma or liver of stressed mice. The gene expressions of antioxidative enzymes (Cu/Zn-SOD, Mn-SOD and GPX) were also up-regulated in the EC-treated group when compared with the stressed group. In addition, EC administration was found to resist a stress-induced increase of plasma corticosterone levels and down-regulation of liver glucocorticoid receptor gene expression. These results suggested that EC could protect against restraint stress-induced liver damage by smoothing stress and promoting antioxidative processes.
authors.affiliation: Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou, China.
authors.forename: Yu-Jia
authors.initials: YJ
authors.lastname: Zhai
authors.forename: Rong-Rong
authors.initials: RR
authors.lastname: He
authors.forename: Bun
authors.initials: B
authors.lastname: Tsoi
authors.forename: Yi-Fang
authors.initials: YF
authors.lastname: Li
authors.forename: Xiao-Di
authors.initials: XD
authors.lastname: Li
authors.forename: Nobuo
authors.initials: N
authors.lastname: Tsuruoka
authors.forename: Keiichi
authors.initials: K
authors.lastname: Abe
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kurihara
mesh_terms: D000410:Alanine Transaminase / Q000235:genetics / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000235:genetics / Q000378:metabolism; D002645:Chickens; D015870:Gene Expression / Q000187:drug effects; D005979:Glutathione Peroxidase / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008107:Liver Diseases / Q000188:drug therapy* / Q000201:enzymology / Q000235:genetics / Q000503:physiopathology*; D008297:Male; D008460:Meat / Q000032:analysis*; D051379:Mice; D018482:Muscle, Skeletal / Q000737:chemistry*; D020011:Protective Agents / Q000008:administration & dosage*; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000187:drug effects; D013482:Superoxide Dismutase / Q000235:genetics / Q000378:metabolism
chemical_list: D020011:Protective Agents; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase