title: Cytotoxic effect of paclitaxel incorporated in nanoparticles based on lactic and glycolic acid copolymer.
abstract: Paclitaxel dosage form on nanoparticles of 200-300 nm based on lactic and glycolic acid copolymer was obtained by the co-precipitation method. The possibility of controlled release of paclitaxel at pH 7.4 for 24 h was studied in vitro. Studies on Jurkat/WT human T-lymphoblastic leukemia cells showed that incorporation of paclitaxel in the nanoparticles led to a 4-fold increase of its cytotoxicity (6.8×10(-6) M) in comparison with paclitaxel solution. The efficiency of compositions containing polysorbate-80 was comparable to that of non-modified nanoparticles containing paclitaxel.
authors.affiliation: Department of Pharmacology, Pharmaceutical Faculty, I. M. Setchenov Moscow Medical University, Russia. vzivkovic@mail.ru
authors.forename: V
authors.initials: V
authors.lastname: Bojat
authors.forename: D S
authors.initials: DS
authors.lastname: Baranov
authors.forename: E A
authors.initials: EA
authors.lastname: Oganesyan
authors.forename: Y M
authors.initials: YM
authors.lastname: Hamdy
authors.forename: V Yu
authors.initials: VY
authors.lastname: Balaban'yan
authors.forename: R N
authors.initials: RN
authors.lastname: Alyautdin
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects / Q000494:pharmacology / Q000633:toxicity; D045744:Cell Line, Tumor; D003692:Delayed-Action Preparations / Q000737:chemistry* / Q000494:pharmacology*; D004327:Drinking Behavior / Q000187:drug effects; D016503:Drug Delivery Systems / Q000379:methods*; D006016:Glycolates / Q000737:chemistry; D006801:Humans; D019169:Jurkat Cells; D019344:Lactic Acid / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry*; D017239:Paclitaxel / Q000009:adverse effects / Q000494:pharmacology* / Q000633:toxicity; D011108:Polymers / Q000737:chemistry / Q000494:pharmacology; D011136:Polysorbates / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D003692:Delayed-Action Preparations; D006016:Glycolates; D011108:Polymers; D011136:Polysorbates; C031149:glycolic acid; D019344:Lactic Acid; D017239:Paclitaxel