title: Primary breast lymphoma sequentially relapsed in the peripheral and central nervous system.
abstract: Primary breast lymphoma (PBL) is an uncommon extranodal type of lymphoma, exhibiting more aggressive behavior and poorer prognosis. Patients with PBL have a higher incidence to relapse in central nervous system (CNS), which is always leading to a dismal outcome even treating with high intensity chemotherapy plus radiotherapy. Lymphoma involving the peripheral nervous system (PNS), either primarily or secondarily, is also rare. But no PBL with PNS relapse has been reported before. Herein, we reported a case of PBL who presented with subsequent relapse in two discrete sites of the PNS followed by the CNS.
authors.affiliation: Division of Hematology-Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, No. 5, Fu-Shin Street, Linkou, Kweishan, Taoyuan 33305, Taiwan. tzungchih@gmail.com
authors.forename: Tzung-Chih
authors.initials: TC
authors.lastname: Tang
authors.forename: Hung
authors.initials: H
authors.lastname: Chang
authors.forename: Wen-Yu
authors.initials: WY
authors.lastname: Chuang
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000150:complications* / Q000473:pathology; D016543:Central Nervous System Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008223:Lymphoma / Q000150:complications*; D008279:Magnetic Resonance Imaging; D010524:Peripheral Nervous System Neoplasms / Q000175:diagnosis / Q000209:etiology*; D049268:Positron-Emission Tomography