title: Self-assembly and paclitaxel loading capacity of cellulose-graft-poly(lactide) nanomicelles.
abstract: A series of amiphiphilic cellulose-based graft copolymers (MCC-g-PLA) with various molecular factors were synthesized in ionic liquid BmimCl and characterized by FT-IR, (1)H NMR, (13)C NMR, XRD, and TGA. Their solubility in a variety of solvents was compared. The prepared MCC-g-PLA copolymers can self-assemble into spherical nanomicelles (10-50 nm) in aqueous solution. The self-assembly behaviors of the MCC-g-PLA copolymers were systematically investigated by fluorescence probe. Furthermore, the hydrophobic antitumor drug paclitaxel (PTX) was successfully encapsulated into the MCC-g-PLA micelles. The drug encapsulation efficiency and loading content were found to be as high as 89.30% (w/w) and 4.97%, respectively. Results in this study not only suggest a promising cellulose-based antitumor drug carrier but also provide information for property-directed synthesis of the cellulose graft PLA copolymers.
authors.affiliation: State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou, China.
authors.forename: Yanzhu
authors.initials: Y
authors.lastname: Guo
authors.forename: Xiaohui
authors.initials: X
authors.lastname: Wang
authors.forename: Xuancai
authors.initials: X
authors.lastname: Shu
authors.forename: Zuguang
authors.initials: Z
authors.lastname: Shen
authors.forename: Run-Cang
authors.initials: RC
authors.lastname: Sun
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry*; D002482:Cellulose / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D017239:Paclitaxel / Q000737:chemistry*; D010316:Particle Size; D011108:Polymers / Q000737:chemistry*; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D011108:Polymers; D002482:Cellulose; D017239:Paclitaxel