title: Preparation of Sr-containing carbonate apatite as a bone substitute and its properties.
abstract: Sr-containing carbonate apatite (SrCAp) specimens of varied Sr contents, ranging from 0 to 13.3 mol%, were prepared through a phosphate treatment of set gypsum-and-carbonate mixture at 100°C for 7 days. Effects of Sr content in SrCAp on microstructure, osteoblast-like cell (MC3T3-E1) attachment and proliferation, and alkaline phosphatase (ALP) activity were evaluated. Sr(2+) ion substituted Ca(2+) ion in the apatite lattice. Carbonate content was about 9-13.6 wt%, increasing in content level as Sr content increased. Sr addition benefited cell attachment but had no significant influence on cell proliferation, although the latter was inhibited at the highest Sr content. ALP activity reached a peak in specimen containing 3.4 mol% of Sr. The present study revealed that SrCAp is a promising candidate for use as a bone substitute material with good resorbabilty and osteoconductivity.
authors.affiliation: Section of Bioengineering, Department of Dental Engineering, Fukuoka Dental College, Fukuoka 814-0193, Japan. tonton10@college.fdcnet.ac.jp
authors.forename: Akiko
authors.initials: A
authors.lastname: Sakai
authors.forename: Alireza
authors.initials: A
authors.lastname: Valanezahad
authors.forename: Masao
authors.initials: M
authors.lastname: Ozaki
authors.forename: Kunio
authors.initials: K
authors.lastname: Ishikawa
authors.forename: Shigeki
authors.initials: S
authors.lastname: Matsuya
mesh_terms: D016475:3T3 Cells; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001031:Apatites / Q000138:chemical synthesis / Q000737:chemistry*; D018786:Bone Substitutes / Q000138:chemical synthesis* / Q000737:chemistry; D002254:Carbonates / Q000138:chemical synthesis / Q000737:chemistry*; D002448:Cell Adhesion; D049109:Cell Proliferation; D004305:Dose-Response Relationship, Drug; D051379:Mice; D015394:Molecular Structure; D010006:Osteoblasts / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D013324:Strontium / Q000008:administration & dosage / Q000737:chemistry*; D013718:Tensile Strength
chemical_list: D001031:Apatites; D018786:Bone Substitutes; D002254:Carbonates; C054286:strontium carbonate; C030782:carboapatite; D000469:Alkaline Phosphatase; D013324:Strontium