title: A flow system for the on-line quantitative measurement of the retention of dosage forms on biological surfaces using spectroscopy and image analysis.
abstract: Measuring the retention, or residence time, of dosage forms to biological tissue is commonly a qualitative measurement, where no real values to describe the retention can be recorded. The result of this is an assessment that is dependent upon a user's interpretation of visual observation. This research paper outlines the development of a methodology to quantitatively measure, both by image analysis and by spectrophotometric techniques, the retention of material to biological tissues, using the retention of polymer solutions to ocular tissue as an example. Both methods have been shown to be repeatable, with the spectrophotometric measurement generating data reliably and quickly for further analysis.
authors.affiliation: Reading School of Pharmacy, University of Reading, Reading, Berkshire RG6 6AD, UK.
authors.forename: Richard A
authors.initials: RA
authors.lastname: Cave
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Cook
authors.forename: Che J
authors.initials: CJ
authors.lastname: Connon
authors.forename: Vitaliy V
authors.initials: VV
authors.lastname: Khutoryanskiy
mesh_terms: D000818:Animals; D002417:Cattle; D019411:Clinical Laboratory Techniques / Q000379:methods; D003315:Cornea / Q000378:metabolism; D004304:Dosage Forms; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D009092:Mucous Membrane / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D013057:Spectrum Analysis / Q000379:methods*; D013678:Technology, Pharmaceutical / Q000379:methods*; D000267:Tissue Adhesions / Q000175:diagnosis* / Q000378:metabolism
chemical_list: D004304:Dosage Forms; D004364:Pharmaceutical Preparations; D011108:Polymers