title: Synthesis of the bacteriocin glycopeptide sublancin 168 and S-glycosylated variants.
abstract: The synthesis of sublancin 168, a unique S-glucosylated bacteriocin antibiotic, is described. The natural product and two S-glycosylated variants were successfully prepared via native chemical ligation followed by folding. The synthetic glycopeptides were shown to possess primarily an α-helical secondary structure by CD and NMR studies.
authors.affiliation: School of Chemistry, The University of Sydney, NSW 2006, Australia.
authors.forename: Yves S Y
authors.initials: YS
authors.lastname: Hsieh
authors.forename: Brendan L
authors.initials: BL
authors.lastname: Wilkinson
authors.forename: Mitchell R
authors.initials: MR
authors.lastname: O'Connell
authors.forename: Joel P
authors.initials: JP
authors.lastname: Mackay
authors.forename: Jacqueline M
authors.initials: JM
authors.lastname: Matthews
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Payne
mesh_terms: D000595:Amino Acid Sequence; D001430:Bacteriocins / Q000138:chemical synthesis* / Q000737:chemistry; D002942:Circular Dichroism; D006020:Glycopeptides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D001430:Bacteriocins; D006020:Glycopeptides; C114602:sublancin 168