title: Crystal structure of the TLDc domain of oxidation resistance protein 2 from zebrafish.
abstract: The oxidation resistance proteins (OXR) help to protect eukaryotes from reactive oxygen species. The sole C-terminal domain of the OXR, named TLDc is sufficient to perform this function. However, the mechanism by which oxidation resistance occurs is poorly understood. We present here the crystal structure of the TLDc domain of the oxidation resistance protein 2 from zebrafish. The structure was determined by X-ray crystallography to atomic resolution (0.97Å) and adopts an overall globular shape. Two antiparallel β-sheets form a central β-sandwich, surrounded by two helices and two one-turn helices. The fold shares low structural similarity to known structures.
authors.affiliation: Department of Molecular Biology and Genetics, Centre for Carbohydrate Recognition and Signalling, Aarhus University, Aarhus, Denmark. mick@mb.au.dk
authors.forename: Mickaël
authors.initials: M
authors.lastname: Blaise
authors.forename: Husam M A B
authors.initials: HM
authors.lastname: Alsarraf
authors.forename: Jaslyn E M M
authors.initials: JE
authors.lastname: Wong
authors.forename: Søren Roi
authors.initials: SR
authors.lastname: Midtgaard
authors.forename: Fabrice
authors.initials: F
authors.lastname: Laroche
authors.forename: Lotte
authors.initials: L
authors.lastname: Schack
authors.forename: Herman
authors.initials: H
authors.lastname: Spaink
authors.forename: Jens
authors.initials: J
authors.lastname: Stougaard
authors.forename: Søren
authors.initials: S
authors.lastname: Thirup
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D018360:Crystallography, X-Ray; D003545:Cysteine / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D051379:Mice; D024101:Mitochondrial Proteins; D008958:Models, Molecular; D008969:Molecular Sequence Data; D056918:Nuclear Receptor Coactivators / Q000737:chemistry; D010084:Oxidation-Reduction; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D015027:Zebrafish / Q000378:metabolism*; D029961:Zebrafish Proteins / Q000737:chemistry* / Q000378:metabolism
chemical_list: D024101:Mitochondrial Proteins; C455500:NCOA7 protein, human; D056918:Nuclear Receptor Coactivators; C419777:OXR1 protein, human; D011506:Proteins; D029961:Zebrafish Proteins; D003545:Cysteine