title: Itch and eczema.
abstract: Eczema/dermatitis belongs to the most pruritic of skin diseases. Pruritogenic mediators in the skin are still mostly unknown. Recent studies, however, have shown that the histamine 4 receptor plays an important role in itch pathophysiology; tryptase and IL-31 are also involved in atopic eczema itch. Differences in itch perception and itch kinetics between healthy volunteers and eczema patients point towards ongoing central nervous inhibitory activity in patients. Questionnaire studies reported comparatively higher loads in affective items chosen by patients with atopic eczema. In the concept of eczema patient management, the therapy of clinical pruritus has to consider pathophysiology and perception by combining topical and systemic treatment.
authors.forename: Ulf
authors.initials: U
authors.lastname: Darsow
authors.forename: Florian
authors.initials: F
authors.lastname: Pfab
authors.forename: Michael
authors.initials: M
authors.lastname: Valet
authors.forename: Thomas R
authors.initials: TR
authors.lastname: Tölle
authors.forename: Johannes
authors.initials: J
authors.lastname: Ring
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging; D003876:Dermatitis, Atopic / Q000378:metabolism / Q000473:pathology; D004485:Eczema / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism*; D006633:Histamine Antagonists / Q000627:therapeutic use; D006801:Humans; D007378:Interleukins / Q000378:metabolism; D049268:Positron-Emission Tomography; D011537:Pruritus / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism*; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism; D011968:Receptors, Histamine / Q000378:metabolism; D000074040:Receptors, Histamine H4; D011795:Surveys and Questionnaires; D053802:Tryptases / Q000378:metabolism
chemical_list: C418607:HRH4 protein, human; D006633:Histamine Antagonists; C502187:IL31 protein, human; D007378:Interleukins; D043562:Receptors, G-Protein-Coupled; D011968:Receptors, Histamine; D000074040:Receptors, Histamine H4; D053802:Tryptases