title: Hepatogenic potential of human bone marrow and umbilical cord blood mesenchymal stem cells.
abstract: Conditions of human BM and umbilical cord blood MSC in vitro differentiation in the hepatogenic direction were studied. Changes in cell morphology, phenotype, acquisition of the capacity to produce albumin and accumulate glycogen, express cytokeratin, alkaline phosphatase, and albumin mRNA indicated that BM and umbilical cord blood MSC differentiated in vitro into immature hepatocyte-like cells.
authors.affiliation: Republican Center of Hematology and Tranfusiology, Minsk, Belarus. 4kosmacheva@mail.ru
authors.forename: S M
authors.initials: SM
authors.lastname: Kosmacheva
authors.forename: I N
authors.initials: IN
authors.lastname: Seviaryn
authors.forename: N V
authors.initials: NV
authors.lastname: Goncharova
authors.forename: N V
authors.initials: NV
authors.lastname: Petyovka
authors.forename: M P
authors.initials: MP
authors.lastname: Potapnev
mesh_terms: D000418:Albumins / Q000096:biosynthesis; D000469:Alkaline Phosphatase / Q000096:biosynthesis; D015703:Antigens, CD / Q000096:biosynthesis; D015415:Biomarkers / Q000378:metabolism; D001854:Bone Marrow Cells / Q000166:cytology* / Q000378:metabolism; D002454:Cell Differentiation / Q000187:drug effects; D002478:Cells, Cultured; D005312:Fetal Blood / Q000166:cytology* / Q000378:metabolism; D005434:Flow Cytometry; D006003:Glycogen / Q000096:biosynthesis; D022781:Hepatocytes / Q000166:cytology* / Q000378:metabolism; D006801:Humans; D016130:Immunophenotyping; D036341:Intercellular Signaling Peptides and Proteins / Q000494:pharmacology; D007633:Keratins / Q000096:biosynthesis; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D012333:RNA, Messenger / Q000096:biosynthesis
chemical_list: D000418:Albumins; D015703:Antigens, CD; D015415:Biomarkers; D036341:Intercellular Signaling Peptides and Proteins; D012333:RNA, Messenger; D007633:Keratins; D006003:Glycogen; D000469:Alkaline Phosphatase