title: [Pathohistological changes in fetuses with cystic fibrosis].
abstract: BACKGROUND
  Cystic fibrosis or mucoviscidosis is a genetically caused disease. The intensity of disease and histopathological changes grow throughout the life. According to the literature, pathological changes characteristic of cystic fibrosis become noticeable around the sixth month of life.
  
  
  METHODS
  After amniocentesis of a 5-lunar month-old fetus had been done, which confirmed cystic fibrosis, the Ethics Commission approved the preterm labor. The autopsy and histopathological analysis demonstrated the existence of typical histopathological changes in the pancreas and intestines.
  
  
  CONCLUSIONS
  In the late fetal period or during the period around the delivery, cystic fibrosis is usually manifested as meconial cap with or without obstruction of the intestinal lumen. Morphological changes in the exocrine glands usually develop only after birth. In this case, the existence of meconial obstruction, as well as the typical acidofil content in the secretory ducts and acini of the pancreas was confirmed, which is unusual for the fetal age of five months.
authors.affiliation: Klinicki centar Vojvodine, Centar za patblogiju i histologiju, Medicinski fakultet Novi Sad. djolaim@gmail.com
authors.forename: Matilda
authors.initials: M
authors.lastname: Dolai
authors.forename: Tamara
authors.initials: T
authors.lastname: Bosković
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Levakov
authors.forename: Kaćanski Mihaela
authors.initials: KM
authors.lastname: Mocko
authors.forename: Bojana
authors.initials: B
authors.lastname: Andrejić
authors.forename: Sandra
authors.initials: S
authors.lastname: Trivunić
mesh_terms: D003550:Cystic Fibrosis / Q000175:diagnosis / Q000196:embryology* / Q000473:pathology; D005260:Female; D005315:Fetal Diseases / Q000473:pathology*; D005865:Gestational Age; D006801:Humans; D011247:Pregnancy