title: A new metric for quantifying performance impairment on the psychomotor vigilance test.
abstract: We have developed a new psychomotor vigilance test (PVT) metric for quantifying the effects of sleep loss on performance impairment. The new metric quantifies performance impairment by estimating the probability density of response times (RTs) in a PVT session, and then considering deviations of the density relative to that of a baseline-session density. Results from a controlled laboratory study involving 12 healthy adults subjected to 85 h of extended wakefulness, followed by 12 h of recovery sleep, revealed that the group performance variability based on the new metric remained relatively uniform throughout wakefulness. In contrast, the variability of PVT lapses, mean RT, median RT and (to a lesser extent) mean speed showed strong time-of-day effects, with the PVT lapse variability changing with time of day depending on the selected threshold. Our analysis suggests that the new metric captures more effectively the homeostatic and circadian process underlying sleep regulation than the other metrics, both directly in terms of larger effect sizes (4-61% larger) and indirectly through improved fits to the two-process model (9-67% larger coefficient of determination). Although the trend of the mean speed results followed those of the new metric, we found that mean speed yields significantly smaller (∼50%) intersubject performance variance than the other metrics. Based on these findings, and that the new metric considers performance changes based on the entire set of responses relative to a baseline, we conclude that it provides a number of potential advantages over the traditional PVT metrics.
authors.affiliation: DoD Biotechnology High-Performance Computing Software Applications Institute, Telemedicine and Advanced Technology Research Center, US Army Medical Research and Materiel Command, Fort Detrick, MD 21702, USA.
authors.forename: Srinivasan
authors.initials: S
authors.lastname: Rajaraman
authors.forename: Sridhar
authors.initials: S
authors.lastname: Ramakrishnan
authors.forename: David
authors.initials: D
authors.lastname: Thorsley
authors.forename: Nancy J
authors.initials: NJ
authors.lastname: Wesensten
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Balkin
authors.forename: Jaques
authors.initials: J
authors.lastname: Reifman
mesh_terms: D000328:Adult; D001143:Arousal / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests / Q000592:standards; D011597:Psychomotor Performance / Q000502:physiology*; D012892:Sleep Deprivation / Q000503:physiopathology*; D013997:Time Factors