title: The oxysterol-binding protein superfamily: new concepts and old proteins.
abstract: The Kes1 OSBP (oxysterol-binding protein) is a key regulator of membrane trafficking through the TGN (trans-Golgi network) and endosomal membranes. We demonstrated recently that Kes1 acts as a sterol-regulated rheostat for TGN/endosomal phosphatidylinositol 4-phosphate signalling. Kes1 utilizes its dual lipid-binding activities to integrate endosomal lipid metabolism with TORC1 (target of rapamycin complex 1)-dependent proliferative pathways and transcriptional control of nutrient signalling.
authors.affiliation: Department of Cell and Developmental Biology, Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7090, USA.
authors.forename: Michelle L
authors.initials: ML
authors.lastname: Villasmil
authors.forename: Vytas A
authors.initials: VA
authors.lastname: Bankaitis
authors.forename: Carl J
authors.initials: CJ
authors.lastname: Mousley
mesh_terms: D000818:Animals; D011992:Endosomes / Q000378:metabolism; D006801:Humans; D005810:Multigene Family; D011987:Receptors, Steroid / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction; D013261:Sterols / Q000378:metabolism; D021601:trans-Golgi Network / Q000378:metabolism; D000098825:Oxysterol Binding Proteins
chemical_list: D011987:Receptors, Steroid; D013261:Sterols; D000098825:Oxysterol Binding Proteins