title: Biological availability and in vitro dissolution of oxytetracycline dihydrate tablets.
abstract: 1 The concentration of oxytetracycline in plasma was studied by microbiological assay after oral administration of four different preparations of oxytetracycline dihydrate tablets. 2 There were statistically significant differences in biological availability between the four preparations, as assessed by the peak plasma level, the area under the plasma concentration-time curve, or the cumulative fraction of the dose excreted in urine at 405 minutes. In contrast, differences between the subjects were not statistically significant. 3 The differences in biological availability were not predictably related to the in vitro dissolution of the tablets.
authors.affiliation: Department of Pharmacology and Therapeutics, University of Liverpool, Liverpool.
authors.forename: H E
authors.initials: HE
authors.lastname: Barber
authors.forename: T N
authors.initials: TN
authors.lastname: Calvey
authors.forename: K
authors.initials: K
authors.lastname: Muir
authors.forename: A
authors.initials: A
authors.lastname: Hart