title: Inflammation-induced alterations in the skin barrier function: implications in atopic dermatitis.
abstract: The pathogenesis of atopic dermatitis (AD) is very complex, but best characterized by an inflammatory reaction in the skin and a disrupted skin barrier. Until recently, these two factors have been studied as separate entities; however, it has been shown that inflammatory cytokines can regulate filaggrin, a very important component of the skin barrier, as well as proteins involved in the processing and maturation of filaggrin. Therefore, inflammation itself may be able to induce a functional skin barrier dysfunction and thereby aggravate the eczematous reaction in AD.
authors.forename: Christian
authors.initials: C
authors.lastname: Vestergaard
authors.forename: Malene
authors.initials: M
authors.lastname: Hvid
authors.forename: Claus
authors.initials: C
authors.lastname: Johansen
authors.forename: Kaare
authors.initials: K
authors.lastname: Kemp
authors.forename: Bent
authors.initials: B
authors.lastname: Deleuran
authors.forename: Mette
authors.initials: M
authors.lastname: Deleuran
mesh_terms: D016207:Cytokines / Q000378:metabolism; D003876:Dermatitis, Atopic / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D000091344:Filaggrin Proteins; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000473:pathology*; D007381:Intermediate Filament Proteins / Q000378:metabolism; D012867:Skin / Q000503:physiopathology*
chemical_list: D016207:Cytokines; C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins