title: Vitamin C improves the quality of somatic cell reprogramming.
abstract: The reprogramming of somatic cells to a pluripotent state is prone to errors that could hamper the use of this technology. A new study now shows that vitamin C enhances the quality of somatic cell reprogramming in mice, highlighting the possibility that further manipulation of culture conditions could improve this technology for regenerative medicine.
authors.affiliation: Stem Cell and Cancer Biology Group at the Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China. esteban@gibh.org
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Esteban
authors.forename: Duanqing
authors.initials: D
authors.lastname: Pei
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D001402:B-Lymphocytes / Q000166:cytology* / Q000378:metabolism*; D002135:Calcium-Binding Proteins; D018392:Genomic Imprinting; D057026:Induced Pluripotent Stem Cells; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics*
chemical_list: D002135:Calcium-Binding Proteins; C512925:Dlk1 protein, mouse; D036341:Intercellular Signaling Peptides and Proteins; D001205:Ascorbic Acid