title: Long-range-projecting GABAergic neurons modulate inhibition in hippocampus and entorhinal cortex.
abstract: The hippocampus and entorhinal cortex play a pivotal role in spatial learning and memory. The two forebrain regions are highly interconnected via excitatory pathways. Using optogenetic tools, we identified and characterized long-range γ-aminobutyric acid-releasing (GABAergic) neurons that provide a bidirectional hippocampal-entorhinal inhibitory connectivity and preferentially target GABAergic interneurons. Activation of long-range GABAergic axons enhances sub- and suprathreshold rhythmic theta activity of postsynaptic neurons in the target areas.
authors.affiliation: Department of Clinical Neurobiology of the Medical Faculty of Heidelberg University and German Cancer Research Center (DKFZ), Heidelberg, Germany.
authors.forename: Sarah
authors.initials: S
authors.lastname: Melzer
authors.forename: Magdalena
authors.initials: M
authors.lastname: Michael
authors.forename: Antonio
authors.initials: A
authors.lastname: Caputi
authors.forename: Marina
authors.initials: M
authors.lastname: Eliava
authors.forename: Elke C
authors.initials: EC
authors.lastname: Fuchs
authors.forename: Miles A
authors.initials: MA
authors.lastname: Whittington
authors.forename: Hannah
authors.initials: H
authors.lastname: Monyer
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology; D056547:CA1 Region, Hippocampal / Q000166:cytology / Q000502:physiology; D018891:Dentate Gyrus / Q000166:cytology / Q000502:physiology; D018728:Entorhinal Cortex / Q000502:physiology*; D059330:GABAergic Neurons / Q000502:physiology*; D006624:Hippocampus / Q000166:cytology / Q000502:physiology*; D007395:Interneurons / Q000502:physiology*; D051379:Mice; D009433:Neural Inhibition; D009434:Neural Pathways; D018408:Patch-Clamp Techniques; D013004:Somatostatin / Q000378:metabolism; D013569:Synapses / Q000502:physiology; D055366:Synaptic Potentials; D013826:Theta Rhythm
chemical_list: D013004:Somatostatin