title: Mucin-rich salivary duct carcinoma with signet-ring cell feature ex pleomorphic adenoma of the submandibular gland: a case report of an unusual histology with immunohistochemical analysis and review of the literature.
abstract: Salivary duct carcinoma (SDC) is a highly aggressive salivary gland carcinoma, and the mucin-rich variant of SDC (mSDC) is extremely rare. We report herein one case of salivary mSDC, showing predominantly signet-ring cell features. The patient was an 84-year-old Japanese woman, who noticed swelling in the left submandibular region. The tumor consisted of two components: one was of mSDC, which contained numerous signet-ring cells in large mucinous lakes, whereas the other was of preexisting pleomorphic adenoma (PA), which showed a hyalinized nodule. mSDC was markedly positive for mucin staining. Signetring cells in the mSDC component were immunopositive for androgen receptor, gross cystic disease fluid protein-15, MUC1, MUC2, MUC5AC, MUC5B, and MUC6, but negative for Her-2 and myoepithelial markers. This case was diagnosed as mSDC with the signet-ring cell feature ex PA. We discuss herein the significance of the signet-ring cell feature in mSDC and the mucin pattern of mSDC.
authors.affiliation: Pathology Division, Shizuoka Cancer Center Hospital and Research Institute, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka, 411-8777, Japan. k.kusafuka@scchr.jp
authors.forename: Kimihide
authors.initials: K
authors.lastname: Kusafuka
authors.forename: Matsuyoshi
authors.initials: M
authors.lastname: Maeda
authors.forename: Masatake
authors.initials: M
authors.lastname: Honda
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakajima
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000473:pathology*; D008949:Adenoma, Pleomorphic / Q000473:pathology*; D000369:Aged, 80 and over; D044584:Carcinoma, Ductal / Q000473:pathology*; D018279:Carcinoma, Signet Ring Cell / Q000473:pathology*; D005260:Female; D006801:Humans; D009077:Mucins / Q000378:metabolism*; D018987:Salivary Ducts / Q000378:metabolism / Q000473:pathology; D012468:Salivary Gland Neoplasms / Q000473:pathology*; D013365:Submandibular Gland Neoplasms / Q000473:pathology*
chemical_list: D009077:Mucins