title: A potential role for zinc alterations in the pathogenesis of Alzheimer's disease.
abstract: Alzheimer's disease (AD), one of the major causes of disability and mortality in Western societies, is a progressive age-related neurodegenerative disorder. Increasing evidence suggests that the etiology of AD may involve disruptions of zinc (Zn) homeostasis. This review discusses current evidence supporting a potential role of Zn and zinc transporters (ZnTs) in processing of the amyloid beta protein precursor (APP) and amyloid beta (Aβ) peptide generation and aggregation.
authors.affiliation: Department of Chemistry and Physics, Southern Arkansas University, Magnolia, AR 71753, USA. gannalyubartseva@saumag.edu
authors.forename: Ganna
authors.initials: G
authors.lastname: Lyubartseva
authors.forename: Mark A
authors.initials: MA
authors.lastname: Lovell
mesh_terms: D000544:Alzheimer Disease / Q000209:etiology* / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000378:metabolism; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D006801:Humans; D015032:Zinc / Q000378:metabolism*
chemical_list: D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D002352:Carrier Proteins; C017800:zinc-binding protein; D015032:Zinc