title: Mice deficient in CD38 develop an attenuated form of collagen type II-induced arthritis.
abstract: CD38, a type II transmembrane glycoprotein expressed in many cells of the immune system, is involved in cell signaling, migration and differentiation. Studies in CD38 deficient mice (CD38 KO mice) indicate that this molecule controls inflammatory immune responses, although its involvement in these responses depends on the disease model analyzed. Here, we explored the role of CD38 in the control of autoimmune responses using chicken collagen type II (col II) immunized C57BL/6-CD38 KO mice as a model of collagen-induced arthritis (CIA). We demonstrate that CD38 KO mice develop an attenuated CIA that is accompanied by a limited joint induction of IL-1β and IL-6 expression, by the lack of induction of IFNγ expression in the joints and by a reduction in the percentages of invariant NKT (iNKT) cells in the spleen. Immunized CD38 KO mice produce high levels of circulating IgG1 and low of IgG2a anti-col II antibodies in association with reduced percentages of Th1 cells in the draining lymph nodes. Altogether, our results show that CD38 participates in the pathogenesis of CIA controlling the number of iNKT cells and promoting Th1 inflammatory responses.
authors.affiliation: Departmento de Biología Molecular, Instituto de Formación e Investigación Marqués de Valdecilla, Universidad de Cantabria, Santander, Spain.
authors.forename: Jorge
authors.initials: J
authors.lastname: Postigo
authors.forename: Marcos
authors.initials: M
authors.lastname: Iglesias
authors.forename: Daniela
authors.initials: D
authors.lastname: Cerezo-Wallis
authors.forename: Antonio
authors.initials: A
authors.lastname: Rosal-Vela
authors.forename: Sonia
authors.initials: S
authors.lastname: García-Rodríguez
authors.forename: Mercedes
authors.initials: M
authors.lastname: Zubiaur
authors.forename: Jaime
authors.initials: J
authors.lastname: Sancho
authors.forename: Ramón
authors.initials: R
authors.lastname: Merino
authors.forename: Jesús
authors.initials: J
authors.lastname: Merino
mesh_terms: D051997:ADP-ribosyl Cyclase 1 / Q000172:deficiency* / Q000235:genetics / Q000276:immunology; D000818:Animals; D000910:Antibodies, Heterophile / Q000097:blood; D001169:Arthritis, Experimental / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D002645:Chickens; D024043:Collagen Type II / Q000276:immunology; D016207:Cytokines / Q000235:genetics; D015870:Gene Expression; D007074:Immunoglobulin G / Q000097:blood; D007371:Interferon-gamma / Q000096:biosynthesis / Q000235:genetics; D053583:Interleukin-1beta / Q000235:genetics; D015850:Interleukin-6 / Q000235:genetics; D008297:Male; D008562:Membrane Glycoproteins / Q000172:deficiency* / Q000235:genetics / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D055611:Natural Killer T-Cells / Q000276:immunology; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D013154:Spleen / Q000276:immunology; D018417:Th1 Cells / Q000276:immunology; D058504:Th17 Cells / Q000276:immunology
chemical_list: D000910:Antibodies, Heterophile; D024043:Collagen Type II; D016207:Cytokines; D007074:Immunoglobulin G; D053583:Interleukin-1beta; D015850:Interleukin-6; D008562:Membrane Glycoproteins; D012333:RNA, Messenger; D007371:Interferon-gamma; C498155:Cd38 protein, mouse; D051997:ADP-ribosyl Cyclase 1