title: A new pancreatic lipase inhibitor from Broussonetia kanzinoki.
abstract: A new phenolic compound, broussonone A (1) were isolated from the stem barks of Broussonetia kanzinoki (Moraceae), together with two diphenylpropanes, broussonin A (2), broussonin B (3), two flavans, 7,4'-dihydroxyflavan (4), 3',7-dihydroxy-4'-methoxyflavan (5), and two flavones, 3,7-dihydroxy-4'-methoxyflavone (6), 3,7,3'-trihydroxy-4'-methoxyflavone (7). Compound 1 showed noncompetitive inhibitory activity on pancreatic lipase with an IC(50) of 28.4 μM. In addition, compounds 1-5 significantly inhibited adipocyte differentiation in 3T3-L1 cells as measured fat accumulation using Oil Red O assay.
authors.affiliation: College of Pharmacy, Chungbuk National University, Heungduk-gu, Cheongju, Republic of Korea.
authors.forename: Jong Hoon
authors.initials: JH
authors.lastname: Ahn
authors.forename: Qing
authors.initials: Q
authors.lastname: Liu
authors.forename: Chul
authors.initials: C
authors.lastname: Lee
authors.forename: Mi-Jeong
authors.initials: MJ
authors.lastname: Ahn
authors.forename: Hwan-Soo
authors.initials: HS
authors.lastname: Yoo
authors.forename: Bang Yeon
authors.initials: BY
authors.lastname: Hwang
authors.forename: Mi Kyeong
authors.initials: MK
authors.lastname: Lee
mesh_terms: D041721:3T3-L1 Cells; D017667:Adipocytes / Q000187:drug effects; D000818:Animals; D001667:Binding, Competitive / Q000187:drug effects; D031623:Broussonetia / Q000737:chemistry*; D002454:Cell Differentiation / Q000187:drug effects; D004789:Enzyme Activation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D008049:Lipase / Q000037:antagonists & inhibitors*; D051379:Mice; D015394:Molecular Structure; D010179:Pancreas / Q000201:enzymology*; D010636:Phenols / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D004791:Enzyme Inhibitors; D010636:Phenols; C574926:broussonone A; D008049:Lipase