title: The mechanism of carvedilol in experimental viral myocarditis.
abstract: Carvedilol is a nonselective β-blocker with α1-adrenergic blocking and antioxidant properties. A number of preclinical experiments and clinical trials have demonstrated that carvedilol provides prominent benefit in heart failure. However, less research has been done in the area of animal models of viral myocarditis. This paper reviews the use of carvedilol in animal models of viral myocarditis. The experimental evidence strongly suggests that carvedilol, but not metoprolol (a selective β1-adrenergic blocking agent), protects against viral myocarditis and the superior cardioprotection effect of carvedilol to metoprolol may be due to its upregulating the production of antiinflammatory cytokines, downregulating the production of proinflammatory cytokines, antioxidative effects, the suppression of matrix metalloproteinases production, and positive hemodynamic effects.
authors.affiliation: Department of Cardiology, Second Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, China. liyuechun1980@sina.com.cn
authors.forename: Li
authors.initials: L
authors.lastname: Yue-Chun
authors.forename: Ge
authors.initials: G
authors.lastname: Li-Sha
authors.forename: Guan
authors.initials: G
authors.lastname: Xue-Qiang
authors.forename: Lin
authors.initials: L
authors.lastname: Jia-Feng
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D002227:Carbazoles / Q000494:pharmacology* / Q000627:therapeutic use; D000077261:Carvedilol; D004195:Disease Models, Animal; D051379:Mice; D009205:Myocarditis / Q000517:prevention & control* / Q000821:virology*; D011412:Propanolamines / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D000319:Adrenergic beta-Antagonists; D002227:Carbazoles; D011412:Propanolamines; D000077261:Carvedilol