title: Clinicopathological features of serrated adenocarcinoma defined by Mäkinen in dukes' B colorectal carcinoma.
abstract: OBJECTIVE
  Serrated adenocarcinoma (SAC), proposed as a new pathologic type, arises predominantly in the right side of the colon and has a poorer prognosis than conventional colorectal carcinoma. The prognosis of colorectal carcinoma is variable in Dukes' B, so the aim of this study was to determine whether or not SAC has a poor prognosis in Dukes' B.
  
  
  METHODS
  The study group comprised 64 patients who underwent surgery for colorectal carcinoma. We undertook a statistical analysis of the association of SAC and non-SAC with sex, age, histologic type, depth of tumor, location of tumor, venous invasion and lymphatic invasion.
  
  
  RESULTS
  SACs were encountered in 17.5% of cases (n = 11). SAC had a less favorable 5-year survival than non-SAC (p = 0.0396 log-rank, Kaplan-Meier). The factors that achieved statistical significance in the univariate analysis were subsequently included in a multivariate analysis and we found that SAC was an independent factor (p = 0.027).
  
  
  CONCLUSIONS
  SAC has a poor prognosis and is not affected by other factors confirming that SAC is an independently less favorable prognostic factor.
authors.affiliation: Department of Surgery 1, Dokkyo University School of Medicine, Mibu, Japan.
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Shida
authors.forename: Takahiro
authors.initials: T
authors.lastname: Fujimori
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Tanaka
authors.forename: Yukari
authors.initials: Y
authors.lastname: Fujimori
authors.forename: Ryusuke
authors.initials: R
authors.lastname: Kimura
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Ueda
authors.forename: Kazuhito
authors.initials: K
authors.lastname: Ichikawa
authors.forename: Shigeki
authors.initials: S
authors.lastname: Tomita
authors.forename: Hitoshi
authors.initials: H
authors.lastname: Nagata
authors.forename: Keiichi
authors.initials: K
authors.lastname: Kubota
authors.forename: Masahiro
authors.initials: M
authors.lastname: Tsubaki
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kato
authors.forename: Takashi
authors.initials: T
authors.lastname: Yao
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Sugai
authors.forename: Kenichi
authors.initials: K
authors.lastname: Sugihara
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Ohkura
authors.forename: Johji
authors.initials: J
authors.lastname: Imura
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D015996:Survival Rate