title: Regulation of GATA4 transcriptional activity in cardiovascular development and disease.
abstract: Transcription factors regulate formation and function of the heart, and perturbation of transcription factor expression and regulation disrupts normal heart structure and function. Multiple mechanisms regulate the level and locus-specific activity of transcription factors, including transcription, translation, subcellular localization, posttranslational modifications, and context-dependent interactions with other transcription factors, chromatin remodeling enzymes, and epigenetic regulators. The zinc finger transcription factor GATA4 is among the best-studied cardiac transcriptional factors. This review focuses on molecular mechanisms that regulate GATA4 transcriptional activity in the cardiovascular system, providing a framework to investigate and understand the molecular regulation of cardiac gene transcription by other transcription factors.
authors.affiliation: Department of Cardiology, Children's Hospital Boston, Boston, Massachusetts, USA.
authors.forename: Pingzhu
authors.initials: P
authors.lastname: Zhou
authors.forename: Aibin
authors.initials: A
authors.lastname: He
authors.forename: William T
authors.initials: WT
authors.lastname: Pu
mesh_terms: D000818:Animals; D002319:Cardiovascular System / Q000196:embryology / Q000254:growth & development / Q000378:metabolism*; D002843:Chromatin; D050991:GATA4 Transcription Factor / Q000235:genetics / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D015533:Transcriptional Activation
chemical_list: D002843:Chromatin; D050991:GATA4 Transcription Factor