title: [Our experience with management of inherited thrombophilia during pregnancy. Preliminary report].
abstract: The physiologic mechanism that results in the occurrence of premenstrual syndrome (PMS) is not well understood.
  
  
  OBJECTIVE
  Effective treatment in premenstrual syndrome with vitex agnus castus--femicur N in adolescent girls. [corrected].
  
  
  METHODS
  We have investigated 45 adolescent girls 14-16 years old for a 3 years period from march 2009 to march 2011. The first group of 23 girls were prescribed Femicur N 4 mg once daily for 3 month--90 capsules per course. The second group of 22 girls were given 40 mg of the study drug (Femicur N) twice a day, from the 19th day of the first day of the cycle for 10 days 3 month as the dose is 60 capsules per course.
  
  
  RESULTS
  Our investigation showed that therapy with VAC-Femicur N in adolescents suffering from PMS was effective and the results were good. From 45 girls 20 girls (44.4%) were without any complaints and 13 girls (28.8%) had reduction of all premenstrual symptoms. In both groups premenstrual mastodynia in 13 girls (28.8%) has disappeard and with 4 girls (8.8%) complaints were redused.
authors.forename: B
authors.initials: B
authors.lastname: Marinov
authors.forename: T
authors.initials: T
authors.lastname: Pramatarova
authors.forename: A
authors.initials: A
authors.lastname: Andreeva
authors.forename: N
authors.initials: N
authors.lastname: Larukova
authors.forename: A
authors.initials: A
authors.lastname: Slavov
mesh_terms: D000293:Adolescent; D005260:Female; D006801:Humans; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D011247:Pregnancy; D011293:Premenstrual Syndrome / Q000175:diagnosis / Q000188:drug therapy*; D020950:Vitex / Q000737:chemistry*
chemical_list: D010936:Plant Extracts; C526687:femicur N