title: Weight loss improves renal hemodynamics in patients with metabolic syndrome.
abstract: OBJECTIVE
  We investigated the impact of weight loss on urinary albumin excretion (UAE) and creatinine clearance in obese patients with metabolic syndrome.
  
  
  METHODS
  Thirty-five obese patients undertook a 12-week calorie-restricted diet. The patients underwent a metabolic (oral glucose tolerance test, plasma lipids, and uric acid) and renal hemodynamic evaluations (creatinine clearance and urinary albumin excretion) before (phase 1), and after the 12-week diet (phase 2).
  
  
  RESULTS
  After the dietary intervention, the subjects were divided into two groups: patients who achieved the target weight reduction (R: responders, n = 14), and patients who did not (NR: non-responders, n = 21). The patients in Group R showed an improvement in lipid profile, a decrease in UAE (median = 162.5 mg/24 hours, range: 0.8 to 292 mg/24 hours, at phase 1 versus 10.4 mg/24 hours, range: 1.6 to 22.4 mg/24 hours, at phase 2), and a significant reduction in creatinine clearance (121.4 ± 66.5 mL/min. in phase 1 to 92.9 ± 35.6 mL/min. at the end of phase 2, p = 0.001). In Group NR, no statistically significant differences were observed between phases 1 and 2.
  
  
  CONCLUSIONS
  Body weight reduction has a positive impact on renal hemodynamics, decreasing urinary albumin excretion as well as glomerular hyperfiltration in obese patients with metabolic syndrome.
authors.affiliation: Universidade Federal de Juiz de Fora – UFJF. daniezequiel@ hotmail.com
authors.forename: Danielle Guedes Andrade
authors.initials: DG
authors.lastname: Ezequiel
authors.forename: Monica Barros
authors.initials: MB
authors.lastname: Costa
authors.forename: Alfredo
authors.initials: A
authors.lastname: Chaoubah
authors.forename: Rogerio Baumgratz
authors.initials: RB
authors.lastname: de Paula
mesh_terms: D000328:Adult; D000419:Albuminuria / Q000517:prevention & control / Q000628:therapy; D031204:Caloric Restriction; D003404:Creatinine / Q000097:blood; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000378:metabolism / Q000503:physiopathology*; D009765:Obesity / Q000150:complications / Q000178:diet therapy / Q000378:metabolism / Q000503:physiopathology; D011446:Prospective Studies; D015431:Weight Loss
chemical_list: D003404:Creatinine