title: Regeneration and outcome of dual grafts in living donor liver transplantation.
abstract: In living donor liver transplantation (LDLT), the essential aims are to provide an adequate graft volume to the recipient and to keep a sufficient remnant liver volume in the donor. In some instances, these aims cannot be met by a single donor and LDLT using dual grafts from two donors is a good solution. From 2002 to 2009, five recipients in our hospital received dual graft LDLT. Two recipients received one right lobe and one left lobe grafts; the other three received two left lobe grafts. The mean final liver regeneration rate was 91.2%. Left lobe graft atrophy in the long term was observed in recipients who received a right and a left lobe grafts. The initial bigger volume graft in all recipients was noted to have better regeneration than the smaller volume grafts. Portal flow and bilateral grafts volume size discrepancy were considered as two major factors influencing graft regeneration in this study. We also noted that the initial graft volume correlated with portal flow in the separate grafts and finally contribute to individual graft regeneration. Because of compensatory hypertrophy of the other graft, recipients who experienced atrophy of one graft did not show signs of liver dysfunction.
authors.affiliation: Liver Transplant Program, Department of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
authors.forename: Chia-Hsun
authors.initials: CH
authors.lastname: Lu
authors.forename: Tai-Yi
authors.initials: TY
authors.lastname: Chen
authors.forename: Tung-Liang
authors.initials: TL
authors.lastname: Huang
authors.forename: Leo Leung-Chit
authors.initials: LL
authors.lastname: Tsang
authors.forename: Hsin-You
authors.initials: HY
authors.lastname: Ou
authors.forename: Chun-Yen
authors.initials: CY
authors.lastname: Yu
authors.forename: Chao-Long
authors.initials: CL
authors.lastname: Chen
authors.forename: Yu-Fan
authors.initials: YF
authors.lastname: Cheng
mesh_terms: D000328:Adult; D006801:Humans; D008102:Liver Circulation; D008115:Liver Regeneration; D016031:Liver Transplantation / Q000009:adverse effects / Q000379:methods*; D019520:Living Donors; D011168:Portal System; D012039:Regional Blood Flow; D020858:Tissue and Organ Harvesting; D055815:Young Adult