title: One-pot synthesis of 4-substituted isoquinolinium zwitterionic salts by metal-free C-H bond activation.
abstract: The unprecedented isoquinolinium zwitterionic salts with an unusual C-4 substitution pattern were efficiently prepared via the multicomponent reaction of in situ formed N-benzylisoquinolinium bromide with aromatic aldehydes and cyclic 1,3-dicarbonyl compounds.
authors.affiliation: College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Hou
authors.forename: Yuan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Chao-Guo
authors.initials: CG
authors.lastname: Yan
mesh_terms: D002244:Carbon / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D006859:Hydrogen / Q000737:chemistry*; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry; D008958:Models, Molecular; D008968:Molecular Conformation; D012492:Salts / Q000737:chemistry*
chemical_list: D007546:Isoquinolines; D007659:Ketones; D012492:Salts; D002244:Carbon; D006859:Hydrogen; C039109:isoquinoline