title: Late onset renal failure and nephrotic syndrome after autologous stem cell transplant for Al amyloidosis.
abstract: We present a patient with AL amyloidosis who had an autologous stem cell transplant (ASCT) over 9 years ago. She has since then developed slowly progressive renal insufficiency and the nephrotic syndrome. Hematologic evaluation has failed to identify recurrent disease and a renal biopsy demonstrated extensive amyloid deposition and substantial glomerulosclerosis. We suggest that the patient has chronic glomerulosclerosis as a consequence of renal damage associated with her disease process and her treatment.
authors.affiliation: Division of Nephrology and Hypertension, University of South Florida College of Medicine, Tampa, FL, USA. srifkin@health.usf.edu
authors.forename: Stephen I
authors.initials: SI
authors.lastname: Rifkin
authors.forename: Samuel S
authors.initials: SS
authors.lastname: Weinstein
mesh_terms: D000686:Amyloidosis / Q000601:surgery*; D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D000075363:Immunoglobulin Light-chain Amyloidosis; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000175:diagnosis / Q000209:etiology*; D051437:Renal Insufficiency / Q000175:diagnosis / Q000209:etiology*; D033581:Stem Cell Transplantation / Q000009:adverse effects*; D013997:Time Factors; D014182:Transplantation, Autologous