title: Associations of childhood trauma with hypothalamic-pituitary-adrenal function in borderline personality disorder and major depression.
abstract: BACKGROUND
  Alterations of the hypothalamus-pituitary-adrenal (HPA) axis are hallmarks in major depressive disorder (MDD) and there is some evidence about similar patterns in borderline personality disorder (BPD). This study examines HPA axis abnormalities with respect to clinical characteristics in both BPD (n=24) and MDD patients (n=33) as well as in healthy control participants (n=41).
  
  
  METHODS
  A 0.5mg dexamethasone suppression test was administered to evaluate basal cortisol release and HPA feedback sensitivity via salivary cortisol. Traumatic experiences in childhood as well as severity of borderline and depressive symptom severity and dissociation were obtained by self-report questionnaires.
  
  
  RESULTS
  Compared to the healthy control group, BPD and MDD patients exhibited both enhanced cortisol concentrations before and after the administration of 0.5mg dexamethasone. Higher cortisol levels were positively correlated to a history of childhood trauma, current dissociative symptoms and severity of borderline and depressive symptoms. Regression analyses revealed that some aspects of early trauma were associated with cortisol release before and after dexamethasone, whereas psychopathology did not contribute to the regression model.
  
  
  CONCLUSIONS
  HPA dysfunctions appear to be related rather to childhood trauma than to psychopathology in adulthood. Exposure to childhood trauma may contribute to long-lasting alterations in HPA activity and might enhance the risk for the development of later mental disorder.
authors.affiliation: Department of Research, Evaluation and Documentation, Clinic of Psychiatry and Psychotherapy Bethel, Ev. Hospital Bielefeld, Bielefeld, Germany.
authors.forename: Silvia
authors.initials: S
authors.lastname: Carvalho Fernando
authors.forename: Thomas
authors.initials: T
authors.lastname: Beblo
authors.forename: Nicole
authors.initials: N
authors.lastname: Schlosser
authors.forename: Kirsten
authors.initials: K
authors.lastname: Terfehr
authors.forename: Christian
authors.initials: C
authors.lastname: Otte
authors.forename: Bernd
authors.initials: B
authors.lastname: Löwe
authors.forename: Oliver Tobias
authors.initials: OT
authors.lastname: Wolf
authors.forename: Carsten
authors.initials: C
authors.lastname: Spitzer
authors.forename: Martin
authors.initials: M
authors.lastname: Driessen
authors.forename: Katja
authors.initials: K
authors.lastname: Wingenfeld
mesh_terms: D000328:Adult; D001883:Borderline Personality Disorder / Q000503:physiopathology*; D002648:Child; D002649:Child Abuse / Q000523:psychology*; D003865:Major Depressive Disorder / Q000503:physiopathology*; D003907:Dexamethasone; D004213:Dissociative Disorders / Q000503:physiopathology / Q000523:psychology; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000032:analysis; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D008297:Male; D010912:Pituitary-Adrenal Function Tests; D010913:Pituitary-Adrenal System / Q000503:physiopathology*; D012463:Saliva / Q000737:chemistry; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D003907:Dexamethasone; D006854:Hydrocortisone