title: Oxidative stress in the in vivo DMBA rat model of breast cancer: suppression by a voltage-gated sodium channel inhibitor (RS100642).
abstract: Breast cancer (BCa) was induced in vivo in female rats with 7,12-dimethylbenz(a)anthracene (DMBA). Two main questions were addressed. Firstly, would the carcinogenesis be accompanied by oxidative stress as signalled by superoxide dismutase, glutathione peroxidase, malondialdehyde and total nitrate? Secondly, would treating the rats additionally with a blocker of voltage-gated sodium channel (VGSC) activity, shown previously to promote BCa progression, affect the oxidative responses? The DMBA-induced increases in the antioxidant systems were completely blocked by the VGSC inhibitor RS100642, which also significantly prolonged the lifespan. We conclude that VGSC inhibition in vivo can significantly protect against oxidative stress and improve survival from tumour burden.
authors.affiliation: Division of Biochemistry, Faculty of Pharmacy, Inonu University, Malatya, Turkey.
authors.forename: Kadir
authors.initials: K
authors.lastname: Batcioglu
authors.forename: A Burcin
authors.initials: AB
authors.lastname: Uyumlu
authors.forename: Basri
authors.initials: B
authors.lastname: Satilmis
authors.forename: Battal
authors.initials: B
authors.lastname: Yildirim
authors.forename: Neslihan
authors.initials: N
authors.lastname: Yucel
authors.forename: Hakan
authors.initials: H
authors.lastname: Demirtas
authors.forename: Rustem
authors.initials: R
authors.lastname: Onkal
authors.forename: R Mine
authors.initials: RM
authors.lastname: Guzel
authors.forename: Mustafa B A
authors.initials: MB
authors.lastname: Djamgoz
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity*; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D005979:Glutathione Peroxidase / Q000235:genetics / Q000378:metabolism; D008315:Malondialdehyde / Q000378:metabolism; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy; D008801:Mexiletine / Q000031:analogs & derivatives* / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015398:Signal Transduction; D026941:Sodium Channel Blockers / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000235:genetics / Q000378:metabolism
chemical_list: C475846:RS100642; D026941:Sodium Channel Blockers; D008801:Mexiletine; D008315:Malondialdehyde; D015127:9,10-Dimethyl-1,2-benzanthracene; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase