title: Influence of rescrubbing before laparotomy closure on abdominal wound infection after colorectal cancer surgery: results of a multicenter randomized clinical trial.
abstract: OBJECTIVE
  To test the hypothesis that strict asepsis in closing wounds following laparotomy reduces the risk for surgical wound infection in elective colorectal cancer surgery.
  
  
  METHODS
  Multicenter randomized clinical trial conducted from June 1, 2009, through June 1, 2010.
  
  
  METHODS
  Colorectal surgery units of 9 Spanish hospitals.
  
  
  METHODS
  A total of 969 patients who underwent elective colorectal cancer surgery were eligible for randomization. In closing the laparotomy wound, the patients were randomized to 2 groups: conventional (n=516) and new operation (n=453). In the conventional group, a new set of instruments was used, surgical staff changed their gloves, and the surgical drapes surrounding the laparotomy were covered by a new set of drapes. The new operation group involved removing all drapes, the surgical staff scrubbed again, and a new set of drapes and instruments was used.
  
  
  METHODS
  Incisional (superficial and deep) surgical site infection 30 days after the operation and risk factors for postoperative wound infections.
  
  
  RESULTS
  A total of 146 incisional surgical site infections (15.1%) were diagnosed. Of these, 96 (9.9%) were superficial and 50 (5.1%) were deep infections. On an intent-to-treat basis, significant differences were found between both groups (66 [12.8%] in the conventional group vs 80 [17.7%] in the new operation group [P=.04]).
  
  
  CONCLUSIONS
  This study does not support the use of rescrubbing to reduce the incidence of incisional surgical site infection.
  
  
  BACKGROUND
  isrctn.org Identifier: ISRCTN19463413
authors.affiliation: Department of Surgery, Colorectal Unit, Virgen del Camino University Hospital, Pamplona, Spain.
authors.forename: Hector
authors.initials: H
authors.lastname: Ortiz
authors.forename: Pedro
authors.initials: P
authors.lastname: Armendariz
authors.forename: Esther
authors.initials: E
authors.lastname: Kreisler
authors.forename: Eduardo
authors.initials: E
authors.lastname: Garcia-Granero
authors.forename: Eloy
authors.initials: E
authors.lastname: Espin-Basany
authors.forename: Jose V
authors.initials: JV
authors.lastname: Roig
authors.forename: Adán
authors.initials: A
authors.lastname: Martín
authors.forename: Alberto
authors.initials: A
authors.lastname: Parajo
authors.forename: Graciela
authors.initials: G
authors.lastname: Valero
authors.forename: Marta
authors.initials: M
authors.lastname: Martínez
authors.forename: Sebastiano
authors.initials: S
authors.lastname: Biondo
mesh_terms: D000368:Aged; D000985:Antisepsis / Q000379:methods*; D016009:Chi-Square Distribution; D015179:Colorectal Neoplasms / Q000601:surgery*; D003107:Colorectal Surgery; D005260:Female; D005932:Gloves, Surgical; D006235:Hand Disinfection; D006801:Humans; D015994:Incidence; D007813:Laparotomy; D008297:Male; D012044:Regression Analysis; D013030:Spain / Q000453:epidemiology; D018709:Statistics, Nonparametric; D058636:Surgical Drapes; D013525:Surgical Instruments; D013530:Surgical Wound Infection / Q000453:epidemiology / Q000517:prevention & control*