title: Camptocormia as a clinical manifestation of polymyositis/systemic sclerosis overlap myositis associated with anti-Ku.
abstract: Camptocormia, an abnormal truncal flexion posture that occurs while walking or standing, is usually caused by various hypokinetic movement disorders, mainly Parkinson disease. We describe the case of a man with subacute onset of camptocormia. Quadriceps muscle biopsy showed significant rhabdomyolysis, few isolated inflammatory cells and mild expression of type I MHC in few fibers, a pattern usually found in immune-mediated necrotizing myopathies. Myositis was associated with Raynaud's phenomenon, mild sclerodactyly, and anti-Ku antibodies leading to the diagnosis of polymyositis/systemic sclerosis overlap myositis. The posture showed modest improvement in response to treatment.
authors.affiliation: Department of Internal Medicine, Centre Hospitalier, 179 boulevard Marechal Juin, 26953, Valence Cedex 9, France. tzenone@ch-valence.fr
authors.forename: Thierry
authors.initials: T
authors.lastname: Zenone
authors.forename: Nathalie
authors.initials: N
authors.lastname: Streichenberger
authors.forename: Marie
authors.initials: M
authors.lastname: Puget
mesh_terms: D000368:Aged; D034961:Antigens, Nuclear / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood*; D004268:DNA-Binding Proteins / Q000276:immunology*; D006801:Humans; D000072200:Ku Autoantigen; D008297:Male; D009134:Muscular Atrophy, Spinal / Q000209:etiology*; D017285:Polymyositis / Q000150:complications* / Q000473:pathology; D012595:Scleroderma, Systemic / Q000150:complications* / Q000473:pathology; D013121:Spinal Curvatures / Q000209:etiology*
chemical_list: D034961:Antigens, Nuclear; D001323:Autoantibodies; D004268:DNA-Binding Proteins; C000606509:Xrcc6 protein, human; D000072200:Ku Autoantigen