title: Investigation and management of hypercalcaemia in children.
abstract: Hypercalcaemia is a far less common finding in children than in adults. It may present with characteristic symptoms or may be identified as a coincidental finding in children investigated for a variety of complaints. Assessment of hypercalcaemia requires an understanding of the normal physiological regulation of plasma calcium by the combined actions of parathyroid hormone, 1,25-dihydroxyvitamin D(3) and the calcium sensing receptor. Hypercalcaemia will usually require treatment using a number of different modalities but occasionally it can be due to a benign asymptomatic condition that requires no intervention. This article presents a logical approach to the investigation and subsequent management of this condition.
authors.affiliation: Department of Paediatric Endocrinology, University Hospital Southampton, Tremona Road, Southampton SO16 6YD, UK.
authors.forename: Justin H
authors.initials: JH
authors.lastname: Davies
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Shaw
mesh_terms: D000328:Adult; D002118:Calcium / Q000097:blood / Q000378:metabolism*; D002648:Child; D006706:Homeostasis; D006801:Humans; D006934:Hypercalcemia / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D010281:Parathyroid Hormone / Q000097:blood / Q000502:physiology*; D014807:Vitamin D / Q000031:analogs & derivatives / Q000502:physiology
chemical_list: D010281:Parathyroid Hormone; D014807:Vitamin D; C097949:1,25-dihydroxyvitamin D; D002118:Calcium