title: Hemodynamic disturbances and activation of lipid peroxidation in the pathogenesis of acute myocardial injury induced by propranolol in toxic doses.
abstract: We studied the dose-dependent cardiotoxic effect of propranolol. Intraperitoneal injection of propranolol in doses of 1 and 2 mg/100 g body weight produced a potent effect on central hemodynamics and myocardial contractility, impaired diastolic relaxation, and caused damage to cardiomyocyte membranes due to activation of free radical oxidation.
authors.affiliation: Khanty-Mansiysk State Medical Academy, Russia. tocsboris@mail.ru
authors.forename: B B
authors.initials: BB
authors.lastname: Yatsinyuk
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D054715:Cardiotoxins / Q000633:toxicity*; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism; D032383:Myocytes, Cardiac / Q000187:drug effects*; D011433:Propranolol / Q000633:toxicity*; D051381:Rats
chemical_list: D054715:Cardiotoxins; D011433:Propranolol