title: Diagnosis, clinical features and treatment outcome of microsporidial keratoconjunctivitis.
abstract: OBJECTIVE
  To report the clinical and microbiological profile of patients with microsporidial keratoconjunctivitis in a tertiary eye care centre in India.
  
  
  METHODS
  A retrospective analysis of medical records of all cases of microbiologically confirmed microsporidial keratoconjunctivitis, who presented between March 2007 and October 2010, was done. In a single-centre, institutional setting, 278 eyes of 277 apparently healthy patients were analysed.
  
  
  RESULTS
  The mean age was 36 ± 14 years (range 6-80). The mean duration of symptoms was 7.7 ± 6.2 days (range 1-60). Keratic precipitates were present in 20.1% patients. A superficial scar was present in 39.2% patients. Majority (26.6%) of the patients reported in the month of August. Microscopic examination of corneal scraping, using potassium hydroxide with calcofluor white and Gram stain, demonstrated microsporidial spores in 98.9% and 89.7% cases, respectively. Patients received either topical 0.02% polyhexamethylene biguanide or lubricants. The mean time for resolution was 6.0 ± 2.9 days (range 2-18). Final visual acuity was ≥ 20/30 in 75.1% cases.
  
  
  CONCLUSIONS
  Microsporidial keratoconjunctivitis is common in India. It is seasonal, can occur in healthy individuals and can be diagnosed using simple microbiological methods. Treatment outcome is generally satisfactory.
authors.affiliation: Cornea and Anterior Segment Service, L. V. Prasad Eye Institute, Patia, Bhubaneswar, Odisha 751024, India. sujatadas@lvpei.org
authors.forename: Sujata
authors.initials: S
authors.lastname: Das
authors.forename: Savitri
authors.initials: S
authors.lastname: Sharma
authors.forename: Srikant K
authors.initials: SK
authors.lastname: Sahu
authors.forename: Shyam S
authors.initials: SS
authors.lastname: Nayak
authors.forename: Sarita
authors.initials: S
authors.lastname: Kar
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001645:Biguanides / Q000627:therapeutic use; D002648:Child; D004202:Disinfectants / Q000627:therapeutic use; D015821:Eye Infections, Fungal / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology*; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D007637:Keratoconjunctivitis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology*; D054327:Lubricants / Q000008:administration & dosage; D008297:Male; D016814:Microsporidia / Q000302:isolation & purification*; D016881:Microsporidiosis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology*; D008875:Middle Aged; D012189:Retrospective Studies; D012621:Seasons; D016896:Treatment Outcome
chemical_list: D001645:Biguanides; D004202:Disinfectants; D054327:Lubricants; C031233:polihexanide