title: Potential effects of dietary folate supplementation on oral carcinogenesis, development and progression.
abstract: Folates are associated with a variety of human health benefits, while folate deficiency has been identified as a potential risk factor for many health problems and cancers, due to its role in dysregulation of DNA synthesis, repair and methylation. The US Food and Drug Administration adopted requirements for folate fortification in some food products, which has resulted in an increase in mean dietary folate intake and a concomitant reduction in the incidence of adverse health effects associated with folate deficiency. This includes a significant reduction in the incidence of folate deficiency-associated birth defects, such as spina bifida.
authors.affiliation: University of Nevada, Las Vegas, School of Dental Medicine, 1001 Shadow Lane, B315, Las Vegas, NV 89106, USA. Karl.Kingsley@unlv.edu
authors.forename: Karl
authors.initials: K
authors.lastname: Kingsley
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000013:Congenital Abnormalities / Q000209:etiology; D004247:DNA; D019587:Dietary Supplements; D018450:Disease Progression; D005492:Folic Acid / Q000494:pharmacology / Q000627:therapeutic use*; D005494:Folic Acid Deficiency / Q000150:complications / Q000188:drug therapy; D006801:Humans; D009062:Mouth Neoplasms / Q000188:drug therapy* / Q000209:etiology; D014777:Virus Diseases; D014803:Vitamin B Complex / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D014803:Vitamin B Complex; D004247:DNA; D005492:Folic Acid