title: Serial 3-dimensional volumetric computed tomography evaluation of lung cancer growth rate in patients with chronic obstructive pulmonary disease findings.
abstract: OBJECTIVE
  The objectives of this study were to compare volume doubling time (VDT) of lung cancer with chronic obstructive pulmonary disease (COPD) findings with that without COPD findings using serial 3-dimensional (3D) volumetric computed tomography (CT) and to investigate the association between VDT and COPD findings.
  
  
  METHODS
  This study included 45 patients with surgically diagnosed non-small cell lung cancer with serial preoperative follow-up CT. Volume doubling time of the nodule was calculated by using 3D volumetric computer software.
  
  
  RESULTS
  Volume doubling time of lung cancer with COPD findings (n = 26) tended to be shorter than that without COPD findings (n = 19) (998 ± 2178 vs 2226 ± 6748 days; P = 0.066). Among COPD findings, severity and pattern of emphysema were significantly correlated with VDT (P < 0.001).
  
  
  CONCLUSIONS
  Volume doubling time of lung cancer with COPD findings on 3D volumetric CT tended to be shorter than that of lung cancer without COPD findings. Severe or paraseptal emphysema may be associated with short VDT of lung cancer with COPD findings.
authors.affiliation: Department of Radiology, Kawasaki Medical School, Kurashiki City, Okayama, Japan. daigoro@med.kawasaki-m.ac.jp
authors.forename: Daigo
authors.initials: D
authors.lastname: Tanimoto
authors.forename: Katsuyoshi
authors.initials: K
authors.lastname: Ito
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Tamada
authors.forename: Atsushi
authors.initials: A
authors.lastname: Higaki
authors.forename: Akihiko
authors.initials: A
authors.lastname: Kanki
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Sato
authors.forename: Yashufumi
authors.initials: Y
authors.lastname: Noda
authors.forename: Hiroki
authors.initials: H
authors.lastname: Higashi
authors.forename: Masao
authors.initials: M
authors.lastname: Nakata
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002289:Carcinoma, Non-Small-Cell Lung / Q000150:complications* / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D016009:Chi-Square Distribution; D018450:Disease Progression; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008175:Lung Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000150:complications* / Q000000981:diagnostic imaging* / Q000473:pathology; D013902:Radiography, Thoracic; D012189:Retrospective Studies; D012720:Severity of Illness Index; D012984:Software; D018709:Statistics, Nonparametric; D014057:Tomography, X-Ray Computed / Q000379:methods*