title: Cytokine reporter mice: the special case of IL-10.
abstract: IL-10 is one of the key cytokines preventing inflammation-mediated tissue damage. In an attempt to identify IL-10-producing cells in vivo, several groups have recently developed IL-10 reporter mouse strains. Up until now, in total, eight IL-10 reporter strains have been published. This incomparable interest in IL-10 reporter mice emphasizes the importance and difficulties in tracking and subsequently investigating the role of IL-10-producing cells in infectious, inflammatory, autoimmune and cancer diseases. In this review, I summarize and compare the properties of those published IL-10 reporter mouse models. I also discuss the necessity to develop new strategies to generate 'multi-cytokine' reporter mouse models enabling highly sensitive in/ex vivo detection of many cytokines in the same single cell. Such 'multi-cytokine' reporter mice will enable to reconsider the dichotomy 'T-effector versus T-regulatory' paradigm and to provide an accurate revised model for cellular sources of cytokines. Finally, I propose to launch cooperative, international initiatives to promote and coordinate the generation of accurate, combinatorial, reporter mice for every individual murine cytokine.
authors.affiliation: Department of Bacteriology, Max von Pettenkofer Institute, Munich, Germany. hicham.bouabe@babraham.ac.uk
authors.forename: H
authors.initials: H
authors.lastname: Bouabe
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D017930:Genes, Reporter / Q000276:immunology*; D016753:Interleukin-10 / Q000235:genetics / Q000276:immunology*; D051379:Mice
chemical_list: C556062:IL10 protein, mouse; D016753:Interleukin-10