title: Local delivery of nitric oxide: targeted delivery of therapeutics to bone and connective tissues.
abstract: Non-invasive treatment of injuries and disorders affecting bone and connective tissue remains a significant challenge facing the medical community. A treatment route that has recently been proposed is nitric oxide (NO) therapy. Nitric oxide plays several important roles in physiology with many conditions lacking adequate levels of NO. As NO is a radical, localized delivery via NO donors is essential to promoting biological activity. Herein, we review current literature related to therapeutic NO delivery in the treatment of bone, skin and tendon repair.
authors.affiliation: Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. snichols@unc.edu
authors.forename: Scott P
authors.initials: SP
authors.lastname: Nichols
authors.forename: Wesley L
authors.initials: WL
authors.lastname: Storm
authors.forename: Ahyeon
authors.initials: A
authors.lastname: Koh
authors.forename: Mark H
authors.initials: MH
authors.lastname: Schoenfisch
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000378:metabolism / Q000473:pathology; D003238:Connective Tissue / Q000378:metabolism / Q000473:pathology; D016503:Drug Delivery Systems; D006801:Humans; D009569:Nitric Oxide / Q000008:administration & dosage* / Q000378:metabolism / Q000627:therapeutic use; D020030:Nitric Oxide Donors / Q000008:administration & dosage* / Q000627:therapeutic use; D012867:Skin / Q000378:metabolism / Q000473:pathology; D013710:Tendons / Q000378:metabolism / Q000473:pathology; D014945:Wound Healing / Q000187:drug effects
chemical_list: D020030:Nitric Oxide Donors; D009569:Nitric Oxide