title: Clinical applications of imaging biomarkers. Part 2. The neurosurgeon's perspective.
abstract: Advances in imaging, including multivoxel spectroscopy, tractography, functional MRI and positron emission spectroscopy, are being used by neurosurgeons to target aggressive areas in gliomas, and to help identify tumour boundaries, functional areas and tracts. Neuro-oncological surgeons need to understand these techniques to help maximise tumour resection, while minimising morbidity in an attempt to improve the quality of patient outcome. This article reviews the evidence for the practical use of multimodal imaging in modern glioma surgery.
authors.affiliation: The Walton Centre NHS Foundation Trust, University of Liverpool, Liverpool, UK. abrodbelt@doctors.org.uk
authors.forename: A
authors.initials: A
authors.lastname: Brodbelt
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D001931:Brain Mapping / Q000379:methods*; D001932:Brain Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000601:surgery*; D003952:Diagnostic Imaging / Q000379:methods*; D056324:Diffusion Tensor Imaging / Q000379:methods; D005910:Glioma / Q000737:chemistry / Q000175:diagnosis / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D016343:Monitoring, Intraoperative / Q000379:methods; D019635:Neurosurgical Procedures / Q000379:methods; D049268:Positron-Emission Tomography / Q000379:methods; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods
chemical_list: D014408:Biomarkers, Tumor