title: An aromatase polymorphism (g.132810C>T) predicts risk of bisphosphonate-related osteonecrosis of the jaw.
abstract: BACKGROUND
  Bisphosphonate (BP)-related osteonecrosis of the jaw (ONJ) is an unpredictable, debilitating adverse effect. Recently, genetic polymorphisms have arisen as promising tools to identify patients with a higher risk of drug-related adverse events.
  
  
  OBJECTIVE
  We aimed to examine the association between the aromatase polymorphism g.132810C>T, and the estrogen receptor polymorphisms g.156705T>C and g.156751A>G, and the risk of BP-related ONJ.
  
  
  METHODS
  Eighty-three subjects were included in the study. A clinical and radiological examination was conducted on oncologic subjects treated with zoledronic acid. Subjects with histologically confirmed ONJ were included in the test group (n = 30) whereas subjects with good oral health were included in control group (n = 53). Aromatase and estrogen receptor polymorphisms from blood samples were analyzed.
  
  
  RESULTS
  The aromatase g.132810C>T polymorphism displayed an over-representation of the TT genotype in the test group (36.67 vs 16.98%; p < 0.05). There was no significant difference in either estrogen receptor polymorphism genotype frequency between the test and control groups.
  
  
  CONCLUSIONS
  Our data suggest a role for the g.132810C>T polymorphism in predicting ONJ risk. These results can pave the way to the personalization of BP therapy, based on individual genotype.
authors.affiliation: Department of Surgery, Section of Oral Surgery, University of Pisa, Italy.
authors.forename: Fabio
authors.initials: F
authors.lastname: La Ferla
authors.forename: Elisa
authors.initials: E
authors.lastname: Paolicchi
authors.forename: Francesco
authors.initials: F
authors.lastname: Crea
authors.forename: Silvia
authors.initials: S
authors.lastname: Cei
authors.forename: Filippo
authors.initials: F
authors.lastname: Graziani
authors.forename: Mario
authors.initials: M
authors.lastname: Gabriele
authors.forename: Romano
authors.initials: R
authors.lastname: Danesi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001141:Aromatase / Q000235:genetics* / Q000378:metabolism; D016022:Case-Control Studies; D004164:Diphosphonates / Q000009:adverse effects*; D047628:Estrogen Receptor alpha / Q000235:genetics / Q000378:metabolism; D005260:Female; D005838:Genotype; D006801:Humans; D007568:Jaw / Q000187:drug effects / Q000201:enzymology; D007571:Jaw Diseases / Q000139:chemically induced / Q000201:enzymology* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010020:Osteonecrosis / Q000139:chemically induced / Q000201:enzymology* / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors
chemical_list: D004164:Diphosphonates; C506487:ESR1 protein, human; D047628:Estrogen Receptor alpha; D001141:Aromatase