title: Body mass index across midlife and cognitive change in late life.
abstract: BACKGROUND
  High midlife body mass index (BMI) has been linked to a greater risk of dementia in late life, but few have studied the effect of BMI across midlife on cognitive abilities and cognitive change in a dementia-free sample.
  
  
  METHODS
  We investigated the association between BMI, measured twice across midlife (mean age 40 and 61 years, respectively), and cognitive change in four domains across two decades in the Swedish Adoption/Twin Study of Aging.
  
  
  RESULTS
  Latent growth curve models fitted to data from 657 non-demented participants showed that persons who were overweight/obese in early midlife had significantly lower cognitive performance across domains in late life and significantly steeper decline in perceptual speed, adjusting for cardio-metabolic factors. Both underweight and overweight/obesity in late midlife were associated with lower cognitive abilities in late life. However, the association between underweight and low cognitive abilities did not remain significant when weight decline between early and late midlife was controlled for.
  
  
  CONCLUSIONS
  There is a negative effect on cognitive abilities later in life related to being overweight/obese across midlife. Moreover, weight decline across midlife rather than low weight in late midlife per se was associated with low cognitive abilities. Weight patterns across midlife may be prodromal markers of late life cognitive health.
authors.affiliation: Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. anna.dahl@ki.se
authors.forename: A K
authors.initials: AK
authors.lastname: Dahl
authors.forename: L B
authors.initials: LB
authors.lastname: Hassing
authors.forename: E I
authors.initials: EI
authors.lastname: Fransson
authors.forename: M
authors.initials: M
authors.lastname: Gatz
authors.forename: C A
authors.initials: CA
authors.lastname: Reynolds
authors.forename: N L
authors.initials: NL
authors.lastname: Pedersen
mesh_terms: D000328:Adult; D000375:Aging; D000704:Analysis of Variance; D015992:Body Mass Index; D003071:Cognition; D003072:Cognition Disorders / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D050177:Overweight / Q000150:complications / Q000453:epidemiology*; D012307:Risk Factors; D011795:Surveys and Questionnaires; D013548:Sweden / Q000453:epidemiology; D013851:Thinness / Q000150:complications / Q000453:epidemiology*