title: Increased risk for CRC in diabetic patients with the nonrisk allele of SNPs at 8q24.
abstract: BACKGROUND
  Colorectal cancer (CRC) oncogenesis was considered to be determined by interactions between genetic and environmental factors. Specific interacting factors that influence CRC morbidity have yet to be fully investigated.
  
  
  METHODS
  A multi-institutional collaborative study with 1511 CRC patients and 2098 control subjects was used to compare the odds ratios for the occurrence of polymorphisms at 11 known single nucleotide polymorphisms (SNPs). TaqMan PCR and questionnaires were used to evaluate the effects of environmental exposures.
  
  
  RESULTS
  Variants of rs6983267 on 8q24 were the most significant markers of risk for CRC (odds ratio 1.16, 95% confidence interval 1.06-1.27, P = 0.0015). Non-insulin-dependent diabetes mellitus (DM), a higher body mass index at age 20, and meat consumption were environmental risk factors, whereas a tuna-rich diet and vitamin intake were protective factors. The cohort of rs6983267 SNP major (T) allele at 8q24 and DM had a 1.66-fold higher risk ratio than the cohort of major allele patients without DM.
  
  
  CONCLUSIONS
  We confirmed that interactions between the genetic background and environmental factors are associated with increased risk for CRC. There is a robust risk of the minor G allele at the 8q24 rs6983267 SNP; however, a major T allele SNP could more clearly reveal a correlation with CRC specifically when DM is present.
authors.affiliation: Department of Surgery, Kyushu University Beppu Hospital, Beppu, Japan.
authors.forename: Shinya
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authors.lastname: Ishimaru
authors.forename: Koshi
authors.initials: K
authors.lastname: Mimori
authors.forename: Ken
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Inoue
authors.forename: Seiya
authors.initials: S
authors.lastname: Imoto
authors.forename: Shuichi
authors.initials: S
authors.lastname: Kawano
authors.forename: Rui
authors.initials: R
authors.lastname: Yamaguchi
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Sato
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Toh
authors.forename: Hisae
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authors.lastname: Iinuma
authors.forename: Toyoki
authors.initials: T
authors.lastname: Maeda
authors.forename: Hideshi
authors.initials: H
authors.lastname: Ishii
authors.forename: Sadao
authors.initials: S
authors.lastname: Suzuki
authors.forename: Shinkan
authors.initials: S
authors.lastname: Tokudome
authors.forename: Masahiko
authors.initials: M
authors.lastname: Watanabe
authors.forename: Jun-ichi
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authors.lastname: Tanaka
authors.forename: Shin-ei
authors.initials: SE
authors.lastname: Kudo
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Sugihara
authors.forename: Kazuo
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authors.lastname: Hase
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Mochizuki
authors.forename: Masato
authors.initials: M
authors.lastname: Kusunoki
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Yamada
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Shimada
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Moriya
authors.forename: Graham F
authors.initials: GF
authors.lastname: Barnard
authors.forename: Satoru
authors.initials: S
authors.lastname: Miyano
authors.forename: Masaki
authors.initials: M
authors.lastname: Mori
mesh_terms: D000367:Age Factors; D000483:Alleles; D000818:Animals; D015992:Body Mass Index; D016022:Case-Control Studies; D002898:Chromosomes, Human, Pair 8; D015179:Colorectal Neoplasms / Q000453:epidemiology* / Q000235:genetics* / Q000473:pathology; D016001:Confidence Intervals; D048909:Diabetes Complications / Q000453:epidemiology*; D005260:Female; D020022:Genetic Predisposition to Disease / Q000453:epidemiology; D006801:Humans; D016015:Logistic Models; D008297:Male; D008460:Meat / Q000009:adverse effects; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D011795:Surveys and Questionnaires; D014413:Tuna; D014815:Vitamins
chemical_list: D014815:Vitamins