title: HLA tissue typing has no effect on the outcome of patients undergoing a living-donor liver transplant: a single-center experience in Egypt.
abstract: OBJECTIVE
  To analyze the effect of human leukocyte antigen tissue typing on outcome of live-donor liver transplant.
  
  
  METHODS
  Fifty recipients underwent live-donor liver transplant in the Dar Al-Fouad Hospital in Egypt and were retrospectively evaluated. Patients were classified into 2 groups: those with human leukocyte antigen +ve, and those with human leukocyte antigen -ve and donors. Hepatitis C virus-related end-stage liver disease was the main indication for transplant. Demographic data, preoperative laboratory data, results of human leukocyte antigen tissue typing, Child score, model for end-stage liver disease score, graft/recipient weight-ratio, ischemia times, surgical complications, postoperative laboratory data, liver biopsy, immunosuppression, and pulse steroids were collected. Graft and patient survivals were studied using Kaplan-Meier curves.
  
  
  RESULTS
  The mean model end-stage liver disease score was 18 ± 3.61 in group 1 and 17.73 ± 3.72 in group 2, with no significant difference. Graft/recipient weight ratio, ischemia times, and postoperative complications showed P = NS. Cyclosporine and tacrolimus were used in 5/9, 8/41, and 4/9 in group 1, and 32/41 in group 2 (P = NS). Rejection and pulse steroids were reported in 3/9 and 12/41 of group 1, and 3/12 and 11/41 of group 2 (P = NS). Hepatitis C virus-recurrence was diagnosed in 5/9 of patients (55%) and 8/41 of patients (29.5%) in groups 1 and 2 (P < .05). No statistical difference was found regarding mortality; 5-year patient and graft survival was 35/50 (70% in group 1 [human leukocyte antigen +ve]), 7/9 (77.8%), and 28/41 in group 2 (68.3%) (human leukocyte antigen -ve).
  
  
  CONCLUSIONS
  Positive human leukocyte antigen typing before live-donor liver transplant has no effect on the incidence of postoperative complications, rejection episodes, and patient or graft survival. Recipients with positive human leukocyte antigen typing may have increased risk of hepatitis C virus-recurrence after live-donor liver transplant.
authors.affiliation: Department of Endemic Medicine and Hepatology, Cairo University, Giza, Egypt.
authors.forename: Ayman
authors.initials: A
authors.lastname: Yosry
authors.forename: Mohamed
authors.initials: M
authors.lastname: Said
authors.forename: Gamal
authors.initials: G
authors.lastname: Esmat
authors.forename: Magdy
authors.initials: M
authors.lastname: Al-Serafy
authors.forename: Ashraf
authors.initials: A
authors.lastname: Omar
authors.forename: Wahid
authors.initials: W
authors.lastname: Doss
authors.forename: Dalia
authors.initials: D
authors.lastname: Omran
authors.forename: Yasmin
authors.initials: Y
authors.lastname: Saad
authors.forename: Sanna
authors.initials: S
authors.lastname: Kamel
authors.forename: Akram
authors.initials: A
authors.lastname: Abdel-Bary
authors.forename: Yaser
authors.initials: Y
authors.lastname: Hatata
authors.forename: Adel
authors.initials: A
authors.lastname: Hosny
mesh_terms: D000328:Adult; D004534:Egypt / Q000453:epidemiology; D058625:End Stage Liver Disease / Q000401:mortality* / Q000601:surgery*; D005260:Female; D006084:Graft Rejection / Q000401:mortality*; D006085:Graft Survival; D019698:Hepatitis C, Chronic / Q000401:mortality; D006650:Histocompatibility Testing; D006801:Humans; D015994:Incidence; D053208:Kaplan-Meier Estimate; D016031:Liver Transplantation / Q000401:mortality*; D019520:Living Donors / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000401:mortality; D015427:Reperfusion Injury / Q000401:mortality; D012189:Retrospective Studies; D055815:Young Adult