title: Prevalence of noncardiac structural anomalies in twin-twin transfusion syndrome.
abstract: OBJECTIVE
  Compared to singleton pregnancies, monochorionic twins have increased rates of perinatal morbidity and mortality, believed due in part to both twin-twin transfusion syndrome and an increased risk of congenital anomalies. Here we describe the prevalence of noncardiac structural anomalies in monochorionic twins with twin-twin transfusion syndrome who underwent laser surgery.
  
  
  METHODS
  In a retrospective study of 221 consecutive cases of twin-twin transfusion syndrome treated with laser surgery, noncardiac anomalies were identified by review of antepartum and neonatal medical records.
  
  
  RESULTS
  Of 377 live-born twins, 19 (5.0%) had a noncardiac anomaly. This rate was increased for donor versus recipient twins (8.5% versus 2.0%; P < .01). The presence of an anomaly was unrelated to the Quintero stage, the presence of donor intrauterine growth restriction, or 30-day survival of the donor or recipient.
  
  
  CONCLUSIONS
  The prevalence of noncardiac anomalies in pregnancies complicated by twin-twin transfusion syndrome who underwent laser surgery was higher in donors versus recipients.
authors.affiliation: Department of Obstetrics and Gynecology, University of Southern California, Los Angeles, CA 90027, USA.
authors.forename: Shivani
authors.initials: S
authors.lastname: Patel
authors.forename: Linda M
authors.initials: LM
authors.lastname: Randolph
authors.forename: Kurt
authors.initials: K
authors.lastname: Benirschke
authors.forename: Arlyn
authors.initials: A
authors.lastname: Llanes
authors.forename: Larisa
authors.initials: L
authors.lastname: Yedigarova
authors.forename: Ramen H
authors.initials: RH
authors.lastname: Chmait
mesh_terms: D000015:Abnormalities, Multiple / Q000000981:diagnostic imaging* / Q000453:epidemiology*; D015897:Comorbidity; D005260:Female; D005330:Fetofetal Transfusion / Q000000981:diagnostic imaging* / Q000453:epidemiology*; D006801:Humans; D007231:Infant, Newborn; D015141:Los Angeles / Q000453:epidemiology; D008297:Male; D015995:Prevalence; D018570:Risk Assessment; D012307:Risk Factors; D014463:Ultrasonography