title: [Pregabalin--a drug with abuse potential?].
abstract: A case of pregabalin misuse associated with delusional ideas in a drug addict is reported. Pregabalin has been approved as an adjunct therapy for epilepsy, but also for neuropathic pain and generalized anxiety disorders and is widely used today. It has also been used in clinical trials to study its potential utility as a treatment for tobacco, alcohol and benzodiazepine addiction. Web sites, case reports and an epidemiological study (Swedish National Register of Adverse Drug Reactions) suggest that the drug may be abused, especially by substance-dependent individuals. Pregabalin was analyzed by LC/MS/MS following precipitation of serum proteins. Vigabatrin was used as internal standard. The concentration of 25 pg pregabalin/mL serum determined in the present case is the second highest value published so far after misuse of the substance. Due to paradoxical agitation, anxiety attacks and abnormal thinking, the man was exculpated. Further studies are required to assess the actual abuse potential of pregabalin.
authors.affiliation: Institut für Rechtsmedizin und Verkehrsmedizin am Universitätsklinikum Heidelberg.
authors.forename: Gisela
authors.initials: G
authors.lastname: Skopp
authors.forename: Gisela
authors.initials: G
authors.lastname: Zimmer
mesh_terms: D000328:Adult; D000700:Analgesics / Q000737:chemistry / Q000493:pharmacokinetics; D000927:Anticonvulsants / Q000737:chemistry / Q000493:pharmacokinetics; D003702:Delusions / Q000097:blood / Q000139:chemically induced*; D003937:Diagnosis, Differential; D004335:Drug and Narcotic Control / Q000331:legislation & jurisprudence*; D006801:Humans; D008297:Male; D000069583:Pregabalin; D011595:Psychomotor Agitation / Q000097:blood / Q000175:diagnosis*; D015813:Substance Abuse Detection / Q000331:legislation & jurisprudence*; D019966:Substance-Related Disorders / Q000097:blood / Q000175:diagnosis*; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics
chemical_list: D000700:Analgesics; D000927:Anticonvulsants; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid