title: Effect of granulocyte colony-stimulating factor administration on tissue regeneration due to carbon tetrachloride-induced liver damage in experimental model.
abstract: The mechanism by which granulocyte colony-stimulating factor (G-CSF) could lead to the protection from liver injury is not well known. Therefore, the resolution of this role needs further basic and clinical experimental investigation. Acute liver injury was induced in rats by single intraperitoneal injection of a 0.50-mL/kg dose of carbon tetrachloride (CCl4 ). Granulocyte colony-stimulating factor or vehicle of 150 µg/kg was given immediately after intoxicating the liver by CCl4 . The animals were divided into four groups of twelve each. Administration of G-CSF caused a decrease in the activity of liver enzymes,  aminotransferases, compared with the untreated group.
authors.affiliation: 1Cellular and Molecular Biology Research Center (CMBRC), Babol University of Medical Sciences, Babol, Iran. dqujeq@hotmail.com
authors.forename: Durdi
authors.initials: D
authors.lastname: Qujeq
authors.forename: Roya
authors.initials: R
authors.lastname: Abassi
authors.forename: Farideh
authors.initials: F
authors.lastname: Faeizi
authors.forename: Hadi
authors.initials: H
authors.lastname: Parsian
authors.forename: Alieh Sohan
authors.initials: AS
authors.lastname: Faraji
authors.forename: Hassan
authors.initials: H
authors.lastname: Taheri
authors.forename: Mohsen
authors.initials: M
authors.lastname: Tatar
authors.forename: Marym M
authors.initials: MM
authors.lastname: Elmi
authors.forename: Sohhrab
authors.initials: S
authors.lastname: Halalkhor
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity*; D002252:Carbon Tetrachloride Poisoning / Q000097:blood / Q000188:drug therapy*; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D020011:Protective Agents / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
chemical_list: D020011:Protective Agents; D016179:Granulocyte Colony-Stimulating Factor; D002251:Carbon Tetrachloride; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase