title: Intravesical application of lidocaine and sodium bicarbonate in the treatment of obstructive idiopathic lower urinary tract disease in cats.
abstract: BACKGROUND
  In human patients with interstitial cystitis, intravesical instillation of alkalinized lidocaine sometimes is associated with sustained amelioration of symptoms beyond the acute treatment phase. Interstitial cystitis shares many features in common with feline idiopathic cystitis.
  
  
  OBJECTIVE
  To evaluate whether intravesical instillation of alkalinized lidocaine decreases recurrence of urethral obstruction and severity of clinical signs in cats with obstructive idiopathic LUTD.
  
  
  METHODS
  Twenty-six cats with obstructive idiopathic LUTD. Twelve cats in case group (treatment with alkalinized lidocaine) and 14 control cats (treatment with placebo or standard treatment).
  
  
  METHODS
  Cats were randomly assigned to treatment (2 or 4 mg/kg lidocaine and sodium bicarbonate) or placebo groups (0.2 mL/kg saline solution and sodium bicarbonate). The intravesical instillation was done once a day for 3 days. Some cats underwent standard treatment only (indwelling urinary catheter for 3 days without intravesical instillations). A 2-week, 1-month, and 2-month follow-up after treatment was made using a questionnaire. The recurrence rate and amelioration scores of clinical signs were assessed and compared.
  
  
  RESULTS
  Recurrence of urethral obstruction was 58% (7/12) in the case group and 57% (8/14) in the control group. Amelioration scores were similar between the 2 groups.
  
  
  CONCLUSIONS
  Intravesical administration of lidocaine for up to 3 consecutive days had no apparent beneficial effect on decreasing recurrence rate and severity of clinical signs in cats with obstructive idiopathic LUTD.
authors.affiliation: Clinic of Small Animal Internal Medicine, University of Zurich, Zurich, Switzerland.
authors.forename: L
authors.initials: L
authors.lastname: Zezza
authors.forename: C E
authors.initials: CE
authors.lastname: Reusch
authors.forename: B
authors.initials: B
authors.lastname: Gerber
mesh_terms: D000283:Administration, Intravesical; D000779:Anesthetics, Local / Q000008:administration & dosage*; D000818:Animals; D002371:Cat Diseases / Q000188:drug therapy* / Q000473:pathology; D002415:Cats; D003556:Cystitis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D005260:Female; D008012:Lidocaine / Q000008:administration & dosage*; D059411:Lower Urinary Tract Symptoms / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D008297:Male; D011446:Prospective Studies; D017693:Sodium Bicarbonate / Q000008:administration & dosage*; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires; D014524:Urethral Obstruction / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*
chemical_list: D000779:Anesthetics, Local; D017693:Sodium Bicarbonate; D008012:Lidocaine