title: [Expression and clinical significance of tumor-associated macrophages and microvessel density in ameloblastomas].
abstract: OBJECTIVE
  To investigate the expression and clinical significance of tumor-associated macrophages (TAMs) and microvessel density (MVD) in ameloblastomas (ABs).
  
  
  METHODS
  The expression of TAMs (CD68) and MVD (CD34) was examined in 101 ABs and 26 oral mucosa by streptavidin-peroxidase (SP) immunohistochemical technique and then quantified. The data were analyzed by Student's t test and Pearson correlation test using SPSS 11.5 software package.
  
  
  RESULTS
  TAMs and MVD were mainly distributed within the stroma of ABS. TAMs count and MVD count were significantly higher in ABs compared with normal oral mucosa (P<0.05). Linear correlation analysis revealed a positive correlation between TAMs count and MVD count in ABs (r=0.428, P<0.05).
  
  
  CONCLUSIONS
  Increased TAMs is associated with angiogenesis and may play an important role in invasive growth of ABs.
authors.affiliation: Department of Pathology, China Medical University, Shenyang, Liaoning Province, China. chinarenms@163.com
authors.forename: Mei-si
authors.initials: MS
authors.lastname: Ren
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Yan
authors.initials: Y
authors.lastname: Guo
authors.forename: Ming
authors.initials: M
authors.lastname: Zhong
mesh_terms: D000564:Ameloblastoma; D006801:Humans; D008264:Macrophages; D055806:Microvessels; D009389:Neovascularization, Pathologic