title: The relationship of clinical, cognitive and social measures in schizophrenia: a preliminary finding combining measures in probands and relatives.
abstract: This study examines performance of schizophrenia patients, unaffected relatives and controls in social cognition, cognitive and psychiatric scales looking for possible markers of vulnerability in schizophrenia. Performance of schizophrenia patients from multiplex families, first-degree relatives, and matched controls was compared and, subsequently, discriminant analysis method was used for identifying the best predictors for group membership. By using Multigroup Discriminant Analyses on the three groups, the best predictors were PANSS, Premorbid Adjustment Scale, Faux Pas test, and a face/emotion categorizing task. This model obtained 82% correct global classification, suggesting that the combination of psychiatric scales and neuropsychological/social cognition tasks are the best approach for characterizing this disease. Although preliminary, our results suggest that social cognition tasks are robust markers of schizophrenia family impairments, and that combining clinical, social and neuropsychological measures is the best approach to asses patients and relatives vulnerability.
authors.affiliation: Laboratory of Cognitive Neuroscience and Sociocognition, Universidad Diego Portales, Santiago, Chile.
authors.forename: David
authors.initials: D
authors.lastname: Huepe
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Riveros
authors.forename: Facundo
authors.initials: F
authors.lastname: Manes
authors.forename: Blas
authors.initials: B
authors.lastname: Couto
authors.forename: Esteban
authors.initials: E
authors.lastname: Hurtado
authors.forename: Marcelo
authors.initials: M
authors.lastname: Cetkovich
authors.forename: Maria
authors.initials: M
authors.lastname: Escobar
authors.forename: Viviana
authors.initials: V
authors.lastname: Vergara
authors.forename: Teresa
authors.initials: T
authors.lastname: Parrao
authors.forename: Agustin
authors.initials: A
authors.lastname: Ibañez
mesh_terms: D000293:Adolescent; D000328:Adult; D003071:Cognition; D003072:Cognition Disorders / Q000175:diagnosis / Q000453:epidemiology*; D015897:Comorbidity; D004644:Emotions / Q000502:physiology; D005190:Family / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D012559:Schizophrenia / Q000175:diagnosis / Q000453:epidemiology*; D012565:Schizophrenic Psychology; D012720:Severity of Illness Index; D012919:Social Behavior