title: A case of type 2 diabetes and metastatic liver cancer exhibiting hypercholesterolemia with abnormal lipoproteins.
abstract: Although the appearance of abnormal lipoproteins in liver diseases is well known, the precise analyses of abnormal lipoproteins remain elusive. Here, we report a 71-year-old woman with type 2 diabetes whose serum cholesterol levels were elevated to 560 mg/dL over a 4-month period. High-performance liquid chromatography demonstrated the presence of lipoprotein-X and lipoprotein-Y and sigmoid colon cancer and multiple liver metastases were found by colonoscopy and computed tomography. Remission of the primary colon cancer and liver lesions was achieved by chemotherapy with oxaliplatin and fluorouracil and her serum cholesterol went back to basal levels associated with the disappearance of abnormal lipoproteins.
authors.affiliation: Department of Medicine and Clinical Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Japan.
authors.forename: Motoko
authors.initials: M
authors.lastname: Kanzaki
authors.forename: Jun
authors.initials: J
authors.lastname: Wada
authors.forename: Atsuko
authors.initials: A
authors.lastname: Nakatsuka
authors.forename: Sanae
authors.initials: S
authors.lastname: Teshigawara
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Murakami
authors.forename: Kentaro
authors.initials: K
authors.lastname: Inoue
authors.forename: Takahiro
authors.initials: T
authors.lastname: Terami
authors.forename: Akihiro
authors.initials: A
authors.lastname: Katayama
authors.forename: Junichiro
authors.initials: J
authors.lastname: Nasu
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Makino
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000150:complications / Q000556:secondary*; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002851:Chromatography, High Pressure Liquid; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D050171:Dyslipidemias / Q000097:blood / Q000150:complications; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D006937:Hypercholesterolemia / Q000209:etiology*; D006973:Hypertension / Q000150:complications; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D008073:Lipoprotein-X / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008113:Liver Neoplasms / Q000097:blood / Q000150:complications / Q000556:secondary*; D009944:Organoplatinum Compounds / Q000008:administration & dosage; D000077150:Oxaliplatin; D012074:Remission Induction; D012811:Sigmoid Neoplasms / Q000097:blood* / Q000150:complications
chemical_list: D007004:Hypoglycemic Agents; D008073:Lipoprotein-X; D008074:Lipoproteins; D009944:Organoplatinum Compounds; C574294:lipoprotein-Y, human; D000077150:Oxaliplatin; D005472:Fluorouracil