title: Gen-2 hand-held optical imager towards cancer imaging: reflectance and transillumination phantom studies.
abstract: Hand-held near-infrared (NIR) optical imagers are developed by various researchers towards non-invasive clinical breast imaging. Unlike these existing imagers that can perform only reflectance imaging, a generation-2 (Gen-2) hand-held optical imager has been recently developed to perform both reflectance and transillumination imaging. The unique forked design of the hand-held probe head(s) allows for reflectance imaging (as in ultrasound) and transillumination or compressed imaging (as in X-ray mammography). Phantom studies were performed to demonstrate two-dimensional (2D) target detection via reflectance and transillumination imaging at various target depths (1-5 cm deep) and using simultaneous multiple point illumination approach. It was observed that 0.45 cc targets were detected up to 5 cm deep during transillumination, but limited to 2.5 cm deep during reflectance imaging. Additionally, implementing appropriate data post-processing techniques along with a polynomial fitting approach, to plot 2D surface contours of the detected signal, yields distinct target detectability and localization. The ability of the gen-2 imager to perform both reflectance and transillumination imaging allows its direct comparison to ultrasound and X-ray mammography results, respectively, in future clinical breast imaging studies.
authors.affiliation: Optical Imaging Laboratory, Department of Biomedical Engineering, Florida International University, 10555 W. Flagler St., Miami, FL 33174, USA. jgonz007@fiu.edu
authors.forename: Jean
authors.initials: J
authors.lastname: Gonzalez
authors.forename: Manuela
authors.initials: M
authors.lastname: Roman
authors.forename: Michael
authors.initials: M
authors.lastname: Hall
authors.forename: Anuradha
authors.initials: A
authors.lastname: Godavarty
mesh_terms: D001943:Breast Neoplasms / Q000175:diagnosis*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D007089:Image Enhancement / Q000295:instrumentation*; D007090:Image Interpretation, Computer-Assisted / Q000295:instrumentation*; D007259:Infrared Rays; D008029:Lighting / Q000295:instrumentation*; D008327:Mammography / Q000295:instrumentation*; D008904:Miniaturization; D019047:Phantoms, Imaging; D010783:Photometry / Q000295:instrumentation*; D014159:Transducers