title: Recurrent diplopia over a 30-year period: natural history of a Lewis and Sumner syndrome.
abstract: We described the case of a patient with recurrent episodes of isolated diplopia over the last 30 years. On her last event, neurological examination revealed not only a right third and sixth cranial nerves involvement, but also a right peripheral facial palsy and a motor weakness on the left ulnar territory. Electrophysiological nerves motor conduction study revealed a conduction block on the left ulnar nerve and a less severe on the right ulnar nerve. Asymmetrical upper limb sensorimotor weakness combined with conduction block and cranial nerves palsy led to a diagnosis of Lewis and Sumner syndrome (LSS). This case is unusual by the presentation of the disease and is, to our knowledge the longer natural disease course of LSS reported. Moreover, it suggests that the recurrent diplopia variant may represent a separate entity with a good prognosis even in absence of invasive treatment.
authors.affiliation: Department of Neurology, Rouen University Hospital and University of Rouen, 76031 Rouen Cedex, France. romain.lefaucheur@chu-rouen.fr
authors.forename: Romain
authors.initials: R
authors.lastname: Lefaucheur
authors.forename: Jean Paul
authors.initials: JP
authors.lastname: Bouwyn
authors.forename: David
authors.initials: D
authors.lastname: Wallon
authors.forename: Anne-Laure
authors.initials: AL
authors.lastname: Bedat-Millet
authors.forename: Patrick
authors.initials: P
authors.lastname: Ahtoy
authors.forename: Guillaume
authors.initials: G
authors.lastname: Perot
authors.forename: Didier
authors.initials: D
authors.lastname: Hannequin
authors.forename: David
authors.initials: D
authors.lastname: Maltête
mesh_terms: D004172:Diplopia / Q000209:etiology* / Q000473:pathology; D019054:Evoked Potentials, Motor; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009431:Neural Conduction / Q000502:physiology; D011129:Polyradiculoneuropathy / Q000150:complications*; D014459:Ulnar Nerve / Q000503:physiopathology