title: Changes in cytokine expression after electroacupuncture in neuropathic rats.
abstract: The production of proinflammatory cytokines including interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) plays a key role in chronic pain such as neuropathic pain. We investigated changes in cytokine expression in injured peripheral nerves and dorsal root ganglia (DRG) following electroacupuncture (EA) treatment. Neuropathic pain was induced by peripheral nerve injury to the left hind limb of Sprague-Dawley rats under pentobarbital anesthesia. Two weeks later, the nerve-injured rats were treated by EA for 10 minutes. The expression levels of IL-1β, IL-6, and TNF-α in peripheral nerves and DRG of neuropathic rats were significantly increased in nerve-injured rats. However, after EA, the cytokine expression levels were noticeably decreased in peripheral nerves and DRG. These results suggest that EA stimulation can reduce the levels of proinflamtory cytokines elevated after nerve injury.
authors.affiliation: Department of Physiology and Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, P.O. Box 8044, Seoul 120-752, Republic of Korea.
authors.forename: Myeoung Hoon
authors.initials: MH
authors.lastname: Cha
authors.forename: Taick Sang
authors.initials: TS
authors.lastname: Nam
authors.forename: Yongho
authors.initials: Y
authors.lastname: Kwak
authors.forename: Hyejung
authors.initials: H
authors.lastname: Lee
authors.forename: Bae Hwan
authors.initials: BH
authors.lastname: Lee