title: Evidence for a link between locus R-R sequence type and outcome of infection with Entamoeba histolytica.
abstract: The results of Entamoeba histolytica infections range from asymptomatic colonization to variable disease outcomes. However, markers that may predict infection outcomes are not known. Here, we investigated sequence types of a non-coding tRNA-linked locus R-R to identify surrogate markers that may show association with infection outcomes. Among 112 clinical samples--21 asymptomatic, 20 diarrhoea/dysentery and 71 liver abscesses--we identified 11 sequence types. Sequence type 5RR was mostly associated with asymptomatic samples, and sequence type 10RR was predominantly associated with the symptomatic (diarrhoea/dysentery and liver abscess) samples. This is the first report that identifies markers that may predict disease outcomes in E. histolytica infection.
authors.affiliation: Division of Infectious Disease and International Health, University of Virginia Health System, Charlottesville, VA 22908, USA. ika3t@virginia.edu
authors.forename: I K M
authors.initials: IK
authors.lastname: Ali
authors.forename: R
authors.initials: R
authors.lastname: Haque
authors.forename: F
authors.initials: F
authors.lastname: Alam
authors.forename: M
authors.initials: M
authors.lastname: Kabir
authors.forename: A
authors.initials: A
authors.lastname: Siddique
authors.forename: W A
authors.initials: WA
authors.lastname: Petri
mesh_terms: D000328:Adult; D002648:Child; D016054:DNA, Protozoan / Q000737:chemistry / Q000235:genetics*; D004748:Entamoeba histolytica / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity*; D004749:Entamoebiasis / Q000469:parasitology* / Q000473:pathology*; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D017422:Sequence Analysis, DNA; D014774:Virulence
chemical_list: D016054:DNA, Protozoan; D005819:Genetic Markers