title: The microRNA regulatory network in normal- and HTLV-1-transformed T cells.
abstract: Recent efforts to understand the molecular networks governing normal T cell development and driving the neoplastic transformation of T cells have brought to light the involvement of microRNAs (miRNAs), a class of noncoding RNAs of approximately 22 nucleotides that regulate gene expression at the posttranscriptional level. In the present review, we compare the expression profiles of miRNAs in normal T cell development to that of transformed T cells using as a model adult T cell leukemia/lymphoma, an aggressive malignancy of mature CD4+ T cells that is caused by infection with human T cell leukemia virus type 1.
authors.affiliation: Department of Surgical Sciences, Oncology and Gastroenterology, University of Padova, Padova, Italy.
authors.forename: Donna M
authors.initials: DM
authors.lastname: D'Agostino
authors.forename: Paola
authors.initials: P
authors.lastname: Zanovello
authors.forename: Toshiki
authors.initials: T
authors.lastname: Watanabe
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Ciminale
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism / Q000473:pathology* / Q000821:virology; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002472:Cell Transformation, Viral; D015972:Gene Expression Regulation, Neoplastic; D015490:HTLV-I Infections / Q000235:genetics / Q000473:pathology; D015368:Human T-lymphotropic virus 1 / Q000235:genetics* / Q000378:metabolism / Q000472:pathogenicity*; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000235:genetics / Q000473:pathology / Q000821:virology; D035683:MicroRNAs / Q000235:genetics* / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D059467:Transcriptome
chemical_list: D035683:MicroRNAs; D012333:RNA, Messenger