title: Fully-branched hyperbranched polymers with a diselenide core as glutathione peroxidase mimics.
abstract: A novel glutathione peroxidase (GPx) mimic has been prepared by incorporation of a selenium-based catalytic unit into the focal point of a fully-branched hyperbranched polymer. First, an AB(2) monomer consisting of isatin and an electron rich aromatic moiety was polycondensed in the presence of 5-nitroisatin as a core reagent, resulting in a polymer with 100% degree of branching. The latter was coupled to the catalytically active moiety, Br(CH(2))(5) SeSe(CH(2))(5) Br, by nucleophilic substitution of the bromides by the residual amide groups of the incorporated nitroisatin core. The obtained polymer has demonstrated prominent GPx activity as desired, which could be attributed to the hydrophobic, densely branched and core-shell structure of the polymer surrounding the catalytic center.
authors.affiliation: The Research Centre for Molecular Science and Engineering, Northeastern University, Shenyang, 110004, P R China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Fu
authors.forename: Junyi
authors.initials: J
authors.lastname: Chen
authors.forename: Huaping
authors.initials: H
authors.lastname: Xu
authors.forename: Chantal
authors.initials: C
authors.lastname: Van Oosterwijck
authors.forename: Xi
authors.initials: X
authors.lastname: Zhang
authors.forename: Wim
authors.initials: W
authors.lastname: Dehaen
authors.forename: Mario
authors.initials: M
authors.lastname: Smet
mesh_terms: D001966:Bromine; D002384:Catalysis; D020134:Catalytic Domain; D005979:Glutathione Peroxidase / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D006878:Hydroxides / Q000737:chemistry; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D016566:Organoselenium Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D010084:Oxidation-Reduction; D058105:Polymerization; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D006878:Hydroxides; D007211:Indoles; D016566:Organoselenium Compounds; D011108:Polymers; D005979:Glutathione Peroxidase; D001966:Bromine