title: Involvement of NF-κB-mediated expression of galectin-3-binding protein             in TNF-α-induced breast cancer cell adhesion.
abstract: Galectin-3-binding protein (G3BP) is highly expressed in various types of             cancer and is thought to be involved in cancer malignancy; however, the role of             G3BP in breast cancer cells is not fully understood. In this study, we investigated             the role of NF-κB in the adhesion of breast cancer cells to a substrate by using             (-)-DHMEQ, a specific inhibitor of NF-κB. (-)-DHMEQ inhibited both TNF-α-induced             G3BP expression and cell adhesion in human breast cancer cell lines. We also found             that knockdown of G3BP suppressed the adhesion, while its overexpression increased             the adhesion. These data reveal that (-)-DHMEQ suppresses breast cancer cell adhesion             by inhibiting NF-κB-regulated G3BP expression.
authors.affiliation: Department of Applied Chemistry, Faculty of Science and Technology,                     Keio University, Yokohama 223‑8522, Japan.
authors.forename: Naruto
authors.initials: N
authors.lastname: Noma
authors.forename: Siro
authors.initials: S
authors.lastname: Simizu
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Kambayashi
authors.forename: Yasuaki
authors.initials: Y
authors.lastname: Kabe
authors.forename: Makoto
authors.initials: M
authors.lastname: Suematsu
authors.forename: Kazuo
authors.initials: K
authors.lastname: Umezawa
mesh_terms: D000951:Antigens, Neoplasm / Q000235:genetics / Q000378:metabolism*; D001549:Benzamides / Q000494:pharmacology; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism*; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D002448:Cell Adhesion / Q000187:drug effects; D045744:Cell Line, Tumor; D003512:Cyclohexanones / Q000494:pharmacology; D005260:Female; D006023:Glycoproteins / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000378:metabolism*; D034622:RNA Interference; D034741:RNA, Small Interfering; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*; D016326:Extracellular Matrix Proteins
chemical_list: D000951:Antigens, Neoplasm; D001549:Benzamides; D014408:Biomarkers, Tumor; D002352:Carrier Proteins; D003512:Cyclohexanones; D006023:Glycoproteins; D016328:NF-kappa B; D034741:RNA, Small Interfering; D014409:Tumor Necrosis Factor-alpha; C081856:LGALS3BP protein, human; D016326:Extracellular Matrix Proteins; C464444:dehydroxymethylepoxyquinomicin