title: A classic twin study of isolated gastroschisis.
abstract: The etiology of gastroschisis remains elusive. A classic twin study was used to assess the relative contribution of environmental and genetic factors in its development. Screening of 4872 twin pregnancies identified three unreported twin pairs comprising two monozygous and one dizygous discordant pair of twins. Review of the literature identified an additional 21 twin pairs. We observed lower pair- and proband-wise concordance rates for monozygotic compared to dizygotic twin pairs, pair- and proband-wise concordance ratios below 1.0. Our results suggest environmental to play a greater role than genetic factors in the development of gastroschisis.
authors.affiliation: University of Bonn, Neonatology, Bonn, Germany.
authors.forename: Anna Carina
authors.initials: AC
authors.lastname: Schulz
authors.forename: Rüdiger
authors.initials: R
authors.lastname: Stressig
authors.forename: Jochen
authors.initials: J
authors.lastname: Ritgen
authors.forename: Soyhan
authors.initials: S
authors.lastname: Bagci
authors.forename: Andreas
authors.initials: A
authors.lastname: Müller
authors.forename: Ulrich
authors.initials: U
authors.lastname: Gembruch
authors.forename: Annegret
authors.initials: A
authors.lastname: Geipel
authors.forename: Christoph
authors.initials: C
authors.lastname: Berg
authors.forename: Peter
authors.initials: P
authors.lastname: Bartmann
authors.forename: Heiko Martin
authors.initials: HM
authors.lastname: Reutter
mesh_terms: D000328:Adult; D004200:Diseases in Twins / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D020139:Gastroschisis / Q000453:epidemiology / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005858:Germany / Q000453:epidemiology; D005865:Gestational Age; D006801:Humans; D008297:Male; D011247:Pregnancy; D011256:Pregnancy Outcome; D059285:Pregnancy, Twin; D012042:Registries; D014429:Twins, Dizygotic / Q000235:genetics; D014430:Twins, Monozygotic / Q000235:genetics