title: The HVEM network: new directions in targeting novel costimulatory/co-inhibitory molecules for cancer therapy.
abstract: The regulation of the immune system is controlled by many cell surface receptors. A prominent representative is the 'molecular switch' HVEM (herpes virus entry mediator) that can activate either proinflammatory or inhibitory signaling pathways. HVEM ligands belong to two distinct families: the TNF-related cytokines LIGHT and lymphotoxin-α, and the Ig-related membrane proteins BTLA and CD160. HVEM and its ligands have been involved in the pathogenesis of various autoimmune and inflammatory diseases, but recent reports indicate that this network may also be involved in tumor progression and resistance to immune response. Here we summarize the recent advances made regarding the knowledge on HVEM and its ligands in cancer cells, and their potential roles in tumor progression and escape to immune responses. Blockade or enhancement of these pathways may help improving cancer therapy.
authors.affiliation: Aix-Marseille Université, F-13284, Marseille, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Pasero
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Speiser
authors.forename: Laurent
authors.initials: L
authors.lastname: Derré
authors.forename: Daniel
authors.initials: D
authors.lastname: Olive
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000276:immunology; D058851:GPI-Linked Proteins / Q000276:immunology; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000276:immunology*; D011971:Receptors, Immunologic / Q000276:immunology; D053240:Receptors, Tumor Necrosis Factor, Member 14 / Q000276:immunology*; D053326:Tumor Necrosis Factor Ligand Superfamily Member 14 / Q000276:immunology
chemical_list: D015703:Antigens, CD; C482586:BTLA protein, human; C114505:CD160 protein, human; D058851:GPI-Linked Proteins; D011971:Receptors, Immunologic; D053240:Receptors, Tumor Necrosis Factor, Member 14; D053326:Tumor Necrosis Factor Ligand Superfamily Member 14