title: The effect of hydrogel injection on cardiac function and myocardial mechanics in a computational post-infarction model.
abstract: An emerging therapy to limit adverse heart remodelling following myocardial infarction (MI) is the injection of polymers into the infarcted left ventricle (LV). In the few numerical studies carried out in this field, the definition and distribution of the hydrogel in the infarcted myocardium were simplified. In this computational study, a more realistic biomaterial distribution was simulated after which the effect on cardiac function and mechanics was studied. A validated finite element heart model was used in which an antero-apical infarct was defined. Four infarct models were created representing different temporal phases in the progression of a MI. Hydrogel layers were simulated in the infarcted myocardium in each model. Biomechanical and functional improvement of the LV was found after hydrogel inclusion in the ischaemic models representing the early phases of MI. In contrast, only functional but no mechanical restitution was shown in the scar model due to hydrogel presence.
authors.affiliation: a Cardiovascular Research Unit, Chris Barnard Division of Cardiothoracic Surgery, University of Cape Town , Cape Town , South Africa.
authors.forename: Jeroen
authors.initials: J
authors.lastname: Kortsmit
authors.forename: Neil H
authors.initials: NH
authors.lastname: Davies
authors.forename: Renee
authors.initials: R
authors.lastname: Miller
authors.forename: Jesse R
authors.initials: JR
authors.lastname: Macadangdang
authors.forename: Peter
authors.initials: P
authors.lastname: Zilla
authors.forename: Thomas
authors.initials: T
authors.lastname: Franz
mesh_terms: D001672:Biocompatible Materials / Q000008:administration & dosage*; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000008:administration & dosage*; D015552:Injections, Intralesional; D008955:Models, Cardiovascular; D009203:Myocardial Infarction / Q000503:physiopathology* / Q000628:therapy*; D009206:Myocardium / Q000378:metabolism; D013314:Stress, Mechanical; D020257:Ventricular Remodeling / Q000187:drug effects
chemical_list: D001672:Biocompatible Materials; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate