title: The characteristics of remnant lipoproteins in the fasting and postprandial plasma.
abstract: BACKGROUND
  Remnant-like lipoprotein particles (RLP) have been measured by cholesterol as RLP-C for CHD risk assessment in the fasting plasma. However, RLP-triglyceride (TG) is a better marker of the characteristics of remnant lipoproteins in the postprandial plasma, especially in plasma with TG concentrations <150 mg/dl.
  
  
  METHODS
  The RLP-TG and RLP-C concentrations in subjects undergoing a health check-up and in volunteers receiving an oral fat load were determined in the fasting and postprandial plasma. TC, TG, HDL-C, LDL-C, apoB 100, apoB48, RLP apoB-100 and RLP apoB48 were also determined.
  
  
  RESULTS
  When fasting TG concentrations were <150 mg/dl, the 95th percentile of RLP-TG was 20mg/dl and the RLP-C 7.5 mg/dl in healthy subjects. The prevalence of RLP-TG and RLP-C above the cut-off values with a TG concentration <150 mg/dl was significantly higher in the metabolic syndrome cases than in the controls. RLP-TG increased significantly in plasma to >20mg/dl after an oral fat load in cases with TG concentrations >80 mg/dl. Further, RLP apoB100, but not RLP apoB48 was highly correlated with the increase of TG in the postprandial plasma.
  
  
  CONCLUSIONS
  RLP-TG and RLP-C were increased significantly above the cut-off values in the postprandial plasma in healthy volunteers from a TG concentration >80 mg/dl. RLP apoB100, but not RLP apoB48, increased significantly when the plasma TG increased after an oral fat load despite the increase of plasma apoB48. The results show that the major lipoproteins which were increased in postprandial plasma were VLDL remnants, not CM remnants.
authors.affiliation: Graduate School of Health Sciences, Gunma University, Maebashi, Gunma, Japan. nakajimak05@ybb.ne.jp
authors.forename: Katsuyuki
authors.initials: K
authors.lastname: Nakajima
authors.forename: Takamitsu
authors.initials: T
authors.lastname: Nakano
authors.forename: Yoshiharu
authors.initials: Y
authors.lastname: Tokita
authors.forename: Takeaki
authors.initials: T
authors.lastname: Nagamine
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Yatsuzuka
authors.forename: Younosuke
authors.initials: Y
authors.lastname: Shimomura
authors.forename: Akira
authors.initials: A
authors.lastname: Tanaka
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Sumino
authors.forename: Makoto
authors.initials: M
authors.lastname: Nara
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Machida
authors.forename: Masami
authors.initials: M
authors.lastname: Murakami
mesh_terms: D000328:Adult; D002784:Cholesterol / Q000737:chemistry; D005215:Fasting / Q000097:blood*; D005260:Female; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood*; D008875:Middle Aged; D019518:Postprandial Period; D015203:Reproducibility of Results
chemical_list: D008074:Lipoproteins; D002784:Cholesterol