title: Influence of surgical resection on plasma endoglin (CD105) level in non‑small cell lung cancer patients.
abstract: OBJECTIVE
  Endoglin is a proliferation-associated antigen on endothelial cells and essential for angiogenesis. Soluble endoglin (s‑endoglin), formed by proteolytic cleavage of ectodomain of membrane receptor could be an indicator of tumor‑activated endothelium. The aim of present study was to analyze changes of s‑endoglin level in plasma of lung cancer patients following surgical resection and to estimate the correlation of s‑endoglin with other soluble receptors, sTie2 and sVEGF R1.
  
  
  METHODS
  The study group consisted of 37 patients with stage I of non-small cell lung cancer. Plasma concentrations of s‑endoglin, sTie2 and sVEGF R1 were evaluated by ELISA, three times: before surgical resection and on postoperative day 7 and 30.
  
  
  RESULTS
  The median of s‑endoglin concentration decreased significantly on postoperative day 7 when compared with preoperative level and next increased on 30(th) day and it was comparable with that before surgery. s-Endoglin correlated with another soluble receptors, with sTie2 both before surgery (r=0.44) and on postoperative day 7 (r=0.52) and on 30(th) day (r=0.58), with sVEGF R1 - only on postoperative day 7 (r=0.75).
  
  
  CONCLUSIONS
  The increased level of serum endoglin in lung cancer patients compared to controls and its changes after surgical treatment suggest potential application of soluble form of endoglin as potential tumor marker.
authors.affiliation: Department of Pathobiochemistry and Clinical Chemistry, Collegium Medicum of Nicolaus Copernicus University, Bydgoszcz, Poland. kopczynska@cm.umk.pl
authors.forename: E
authors.initials: E
authors.lastname: Kopczyńska
authors.forename: M
authors.initials: M
authors.lastname: Dancewicz
authors.forename: J
authors.initials: J
authors.lastname: Kowalewski
authors.forename: R
authors.initials: R
authors.lastname: Makarewicz
authors.forename: H
authors.initials: H
authors.lastname: Kardymowicz
authors.forename: A
authors.initials: A
authors.lastname: Kaczmarczyk
authors.forename: T
authors.initials: T
authors.lastname: Tyrakowski
mesh_terms: D015703:Antigens, CD / Q000097:blood*; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood* / Q000601:surgery*; D000071063:Endoglin; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood* / Q000601:surgery*; D042787:Receptor, TIE-2 / Q000097:blood; D011956:Receptors, Cell Surface / Q000097:blood*; D013997:Time Factors; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000097:blood
chemical_list: D015703:Antigens, CD; C064206:ENG protein, human; D000071063:Endoglin; D011956:Receptors, Cell Surface; D042787:Receptor, TIE-2; D040281:Vascular Endothelial Growth Factor Receptor-1