title: ALK and MYCN: when two oncogenes are better than one.
abstract: Mutations of ALK are frequently observed in MYCN-amplified neuroblastomas and correlate with poor clinical outcome, but how these oncogenes cooperate in neuroblastoma development remains unclear. In this issue of Cancer Cell, Zhu et al. describe a mechanism by which ALK and MYCN synergistically induce neuroblastoma in the zebrafish model system.
authors.affiliation: Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, 9000 Rockville Pike, Bethesda, MD 20892, USA.
authors.forename: Zhihui
authors.initials: Z
authors.lastname: Liu
authors.forename: Carol J
authors.initials: CJ
authors.lastname: Thiele