title: Case report: Post-traumatic memories triggered by donepezil in a dose-dependent pattern.
abstract: BACKGROUND
  This case report describes a new adverse drug event due to use of donepezil in a patient with probable Alzheimer's Disease.
  
  
  METHODS
  While receiving a 10-mg dose of donepezil nightly, an 87-year old veteran of World War II experienced irrepressible memories of a kamikaze strike. This symptom did not occur at a 5-mg dose of donepezil and resolved with downward titration of this agent.
  
  
  CONCLUSIONS
  This sequence of dosage and symptoms suggests acetylcholinesterase inhibition was the trigger for release of these memories, which are otherwise mostly chronically repressed in this individual.
authors.affiliation: Albany Medical College, Department of Internal Medicine, Division of Geriatric Medicine, Alden March Bioethics Institute, New York, USA. mwolff@communitycare.com
authors.forename: Michael L
authors.initials: ML
authors.lastname: Wolff
mesh_terms: D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000188:drug therapy*; D002800:Cholinesterase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D000077265:Donepezil; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007189:Indans / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D061212:Memory, Episodic; D010880:Piperidines / Q000009:adverse effects* / Q000627:therapeutic use; D013313:Stress Disorders, Post-Traumatic / Q000139:chemically induced*
chemical_list: D002800:Cholinesterase Inhibitors; D007189:Indans; D010880:Piperidines; D000077265:Donepezil