title: The effect of thyroid disorders on lipid levels and metabolism.
abstract: Thyroid hormones regulate cholesterol and lipoprotein metabolism, whereas thyroid disorders, including overt and subclinical hypothyroidism, considerably alter lipid profile and promote cardiovascular disease. Good evidence shows that high thyroid-stimulating hormone (TSH) is associated with a nonfavorable lipid profile, although TSH has no cutoff threshold for its association with lipids. Thyromimetics represent a new class of hypolipidemic drugs: their imminent application in patients with severe dyslipidemias, combined or not with statins, will improve the lipid profile, potentially accelerate energy expenditure and, as a consequence, vitally lessen the risk of cardiovascular disease.
authors.affiliation: Endocrine Unit, Evgenidion Hospital, University of Athens, 20 Papadiamantopoulou Street, 11528 Athens, Greece. ledunt@otenet.gr
authors.forename: Leonidas H
authors.initials: LH
authors.lastname: Duntas
authors.forename: Gabriela
authors.initials: G
authors.lastname: Brenta
mesh_terms: D002784:Cholesterol / Q000378:metabolism*; D008078:Cholesterol, LDL / Q000378:metabolism; D003327:Coronary Disease / Q000209:etiology / Q000378:metabolism* / Q000517:prevention & control; D006801:Humans; D007037:Hypothyroidism / Q000150:complications / Q000378:metabolism; D050356:Lipid Metabolism; D008075:Lipoproteins, HDL / Q000378:metabolism; D018716:Molecular Mimicry; D012307:Risk Factors; D013959:Thyroid Diseases / Q000150:complications* / Q000378:metabolism*; D013963:Thyroid Hormones / Q000378:metabolism* / Q000627:therapeutic use; D013972:Thyrotropin / Q000378:metabolism; D013974:Thyroxine / Q000378:metabolism; D014280:Triglycerides / Q000378:metabolism
chemical_list: D008078:Cholesterol, LDL; D008075:Lipoproteins, HDL; D013963:Thyroid Hormones; D014280:Triglycerides; D013972:Thyrotropin; D002784:Cholesterol; D013974:Thyroxine