title: Effect of simultaneous exposure to benzene and ethanol on urinary thioether excretion.
abstract: The toxicity of benzene is not an issue of the past, especially in developing countries. Bone marrow toxicity is demonstrated among workers. In this study, the effect of simultaneous exposure to benzene and ethanol on benzene metabolism in mice was investigated by measuring the excretion of thioethers in urine. Urinary thioether excretion significantly decreased in the mice receiving both benzene and ethanol compared with the animals receiving benzene only. The assay of determining thioethers in urine samples in this study is a simple and low-cost method, thus suitable for routine use, especially in developing countries, not only for benzene, but also for other alkilating agents, which can be found during occupational exposure. Our results suggest that further research is needed to elucidate the mechanisms of decreased urinary excretion of thioether after simultaneous exposure to benzene and ethanol.
authors.affiliation: Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia. driva@eunet.rs
authors.forename: Ivan
authors.initials: I
authors.lastname: Mikov
authors.forename: Karmen
authors.initials: K
authors.lastname: Stankov
authors.forename: Velibor
authors.initials: V
authors.lastname: Vasovic
authors.forename: Aleksandra
authors.initials: A
authors.lastname: Mikov
authors.forename: Svetlana
authors.initials: S
authors.lastname: Golocorbin-Kon
authors.forename: Momir
authors.initials: M
authors.lastname: Mikov
mesh_terms: D000818:Animals; D001554:Benzene / Q000378:metabolism* / Q000633:toxicity*; D001853:Bone Marrow / Q000378:metabolism; D000431:Ethanol / Q000378:metabolism* / Q000633:toxicity*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D016273:Occupational Exposure / Q000009:adverse effects*; D013440:Sulfides / Q000652:urine*
chemical_list: D013440:Sulfides; D000431:Ethanol; D001554:Benzene