title: Chemical composition and in vitro antimicrobial activity of the essential oil of Cyclotrichium leucotrichum from Iran.
abstract: The objective of this study was to investigate in vitro antimicrobial activity and composition of the essential oil of Cyclotrichium leucotrichum growing wild in Iran. The essential oil was obtained by hydro-distillation and analysed by GC-FID and GC/MS. Fifty-nine components representing 98.9% of the total oil were characterised. The essential oil which has 1,8-cineol (14.8%), elemol (12.6%), spathulenol (9.4%), E-caryophyllene (5.7%) and hinesol (5.7%) as its main components, exhibited moderate activity against seven bacteria and a yeast, Candida albicans, with minimum inhibitory concentration values ranging from 0.5 to 64 mg mL(-1) and minimum bactericidal concentration values ranging from 2 to >64 mg mL(-1), respectively. The best inhibitory effects were against three gram-positive bacteria and tested yeast, C. albicans.
authors.affiliation: Department of Agriculture, Medicinal Plants and Drugs Research Institute, Shahid Beheshti University, G.C., Evin, Tehran, Iran. m-mirjalili@sbu.ac.ir
authors.forename: M H
authors.initials: MH
authors.lastname: Mirjalili
authors.forename: J
authors.initials: J
authors.lastname: Hadian
authors.forename: A
authors.initials: A
authors.lastname: Aliahmadi
authors.forename: M R
authors.initials: MR
authors.lastname: Kanani
authors.forename: A
authors.initials: A
authors.lastname: Sonboli
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D007492:Iran; D009822:Oils, Volatile / Q000737:chemistry* / Q000494:pharmacology*; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000737:chemistry / Q000494:pharmacology; D013141:Spiro Compounds / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D009822:Oils, Volatile; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; D013141:Spiro Compounds; C065858:hinesol; C013258:spathulenol; C024714:caryophyllene; C033011:elemol