title: [Timing of polyethylene glycol administration is a key factor in the tolerability and efficacy of colon preparation in colorectal cancer screening].
abstract: BACKGROUND
  The quality and tolerability of antegrade gut lavage bowel preparation are key elements in the success of population-based colorectal cancer screening.
  
  
  OBJECTIVE
  To evaluate cleansing quality and tolerability according to the timing of polyethylene glycol administration in persons undergoing colorectal cancer screening.
  
  
  METHODS
  Participants in colorectal cancer screening were randomized to two groups: a) control group (colonoscopy scheduled at 9-12 h); preparation with polyethylene glycol on the previous afternoon; b) study group (colonoscopy scheduled at 12-15 h): preparation with polyethylene glycol on the morning of the colonoscopy, with the option of a split dose. The quality of cleansing was evaluated with the Boston scale and tolerability through a questionnaire.
  
  
  RESULTS
  A total of 282 participants were included: preparation was carried out the day before the procedure in 134 and on the same day in 148, of which 26 received a split dose. Cleansing was adequate in 95% (n=268) of the participants. The quality of cleansing was higher in the study group (P=.045). The interval between the end of administration and the beginning of the procedure was inversely correlated with the Boston scale score (P=.036; r=-0.125). Tolerability was unrelated to the time of administration (P>.2). Acceptance of the timing of administration was lower in the study group than in the control group (26% vs 10%, respectively; P=.001).
  
  
  CONCLUSIONS
  Preparation as close as possible to the colonoscopy improves the quality of cleansing with no detrimental effects on tolerability, although this option is less comfortable.
authors.affiliation: Servicio de Gastroenterología, Institut Clínic de Malalties Digestives i Metabòliques, Hospital Clínic, Barcelona, España.
authors.forename: Cristina
authors.initials: C
authors.lastname: Rodríguez De Miguel
authors.forename: Anna
authors.initials: A
authors.lastname: Serradesanferm
authors.forename: Sabrina
authors.initials: S
authors.lastname: Del Manzano
authors.forename: Andrés
authors.initials: A
authors.lastname: Cárdenas
authors.forename: Gloria
authors.initials: G
authors.lastname: Fernández-Esparrach
authors.forename: Angels
authors.initials: A
authors.lastname: Ginés
authors.forename: Elena
authors.initials: E
authors.lastname: Ricart
authors.forename: Oriol
authors.initials: O
authors.lastname: Sendino
authors.forename: Begoña
authors.initials: B
authors.lastname: González-Suárez
authors.forename: María
authors.initials: M
authors.lastname: López-Cerón
authors.forename: Josep
authors.initials: J
authors.lastname: Llach
authors.forename: Jaume
authors.initials: J
authors.lastname: Grau
authors.forename: Antoni
authors.initials: A
authors.lastname: Castells
authors.forename: María
authors.initials: M
authors.lastname: Pellisé
mesh_terms: D003113:Colonoscopy / Q000009:adverse effects / Q000379:methods*; D015179:Colorectal Neoplasms / Q000473:pathology*; D055088:Early Detection of Cancer; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011092:Polyethylene Glycols / Q000008:administration & dosage*; D011446:Prospective Studies; D007507:Therapeutic Irrigation; D013997:Time Factors
chemical_list: D011092:Polyethylene Glycols