title: Thioglycine and L-thiovaline: biologically active H₂S-donors.
abstract: Thioglycine and l-thiovaline are stable under acidic and basic conditions but in the presence of bicarbonate they liberate the gasotransmitter H(2)S. In cells both thioamino acids were proven to enhance cGMP formation and promote vasorelaxation in mouse aortic rings. Given that H(2)S is known to lower arterial hypertension, reduce oxidative stress and exhibit cardioprotective effects in preclinical models, H(2)S donors hold promise as novel treatments for cardiovascular diseases.
authors.affiliation: Department of Pharmacy, Laboratory of Molecular Pharmacology, University of Patras, Greece.
authors.forename: Zongmin
authors.initials: Z
authors.lastname: Zhou
authors.forename: Margarete
authors.initials: M
authors.lastname: von Wantoch Rekowski
authors.forename: Ciro
authors.initials: C
authors.lastname: Coletta
authors.forename: Csaba
authors.initials: C
authors.lastname: Szabo
authors.forename: Mariarosaria
authors.initials: M
authors.lastname: Bucci
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Cirino
authors.forename: Stavros
authors.initials: S
authors.lastname: Topouzis
authors.forename: Andreas
authors.initials: A
authors.lastname: Papapetropoulos
authors.forename: Athanassios
authors.initials: A
authors.lastname: Giannis
mesh_terms: D000596:Amino Acids / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D001011:Aorta / Q000187:drug effects* / Q000378:metabolism; D006152:Cyclic GMP / Q000096:biosynthesis / Q000378:metabolism; D005998:Glycine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006862:Hydrogen Sulfide / Q000737:chemistry / Q000378:metabolism*; D051379:Mice; D032389:Myocytes, Smooth Muscle / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D014633:Valine / Q000031:analogs & derivatives* / Q000494:pharmacology*
chemical_list: D000596:Amino Acids; D006152:Cyclic GMP; D014633:Valine; D005998:Glycine; D006862:Hydrogen Sulfide