title: A practical preparation of highly versatile N-acylpyrroles from 2,4,4-trimethoxybutan-1-amine.
abstract: A novel method for the preparation of N-acylpyrrole is described. The method involves condensation of carboxylic acids with 2,4,4-trimethoxybutan-1-amine, followed by acid-mediated cyclization to form the pyrrole ring. The preparative procedure is highly tolerant of a variety of functional groups.
authors.affiliation: Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Maehara
authors.forename: Rentaro
authors.initials: R
authors.lastname: Kanno
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yokoshima
authors.forename: Tohru
authors.initials: T
authors.lastname: Fukuyama
mesh_terms: D002082:Butylamines / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D015394:Molecular Structure; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: C572819:2,4,4-trimethoxybutan-1-amine; D002082:Butylamines; D002264:Carboxylic Acids; D011758:Pyrroles