title: Endovascular treatment of in-stent restenosis using excimer laser angioplasty and drug eluting balloons.
abstract: In-stent restenosis after endovascular treatment of stenotic and occlusive disease of the infrainguinal arteries is still a clinical challenge. In this paper an overview of the current status of drug-eluting balloon technology and results of clinical trials with drug-eluting balloon angioplasty is given. Furthermore a case series of 10 patients with in-stent restenosis that were treated with excimer laser angioplasty and drug eluting balloons is described. In this case series the mean lesion length treated was 115 mm, and the mean time to occurrence of restenosis after initial treatment was 7.2 months. At a mean follow-up (of all patients) of 7.6 months no target vessel revascularization was seen. In 7 patients that had Duplex and/or angiographic control (mean follow-up 7 months) no signs of neointimal hyperplasia were demonstrated. These short-term data compare favorable to results obtained with standard balloon angioplasty and cutting-balloon angioplasty. Long-term follow-up is necessary to define the role of combined excimer laser and drug-eluting balloon angioplasty in the treatment of in-stent restenosis further.
authors.affiliation: Service of Interventional Radiology, Ospedale Regionale di Lugano, Lugano, Switzerland. jos.vandenberg@eoc.ch
authors.forename: J C
authors.initials: JC
authors.lastname: Van Den Berg
authors.forename: M
authors.initials: M
authors.lastname: Pedrotti
authors.forename: R
authors.initials: R
authors.lastname: Canevascini
authors.forename: S
authors.initials: S
authors.lastname: Chimchila Chevili
authors.forename: L
authors.initials: L
authors.lastname: Giovannacci
authors.forename: R
authors.initials: R
authors.lastname: Rosso
mesh_terms: D000800:Angioplasty, Balloon / Q000295:instrumentation*; D016342:Angioplasty, Laser / Q000379:methods*; D054855:Drug-Eluting Stents; D057510:Endovascular Procedures / Q000379:methods*; D006083:Graft Occlusion, Vascular / Q000628:therapy*; D006801:Humans; D054018:Lasers, Excimer / Q000627:therapeutic use*