title: Prognostic impacts of hypoxic markers in soft tissue sarcoma.
abstract: Background. We aimed to explore the prognostic impact of the hypoxia-induced factors (HIFαs) 1 and 2, the metabolic HIF-regulated glucose transporter GLUT-1, and carbonic anhydrase IX (CAIX) in non-gastrointestinal stromal tumor soft tissue sarcomas (non-GIST STS). Methods. Duplicate cores with viable tumor tissue from 206 patients with non-GIST STS were obtained and tissue microarrays were constructed. Immunohistochemistry (IHC) was used to evaluate expression of hypoxic markers. Results. In univariate analyses, GLUT-1 (P < 0.001) and HIF-2α (P = 0.032) expression correlated significantly with a poor disease-specific survival (DSS). In the multivariate analysis, however, only high expression of GLUT-1 (HR 1.7, CI 95% 1.1-2.7, P = 0.021) was a significant independent prognostic indicator of poor DSS. Conclusion. GLUT-1 is a significant independent negative prognostic factor in non-GIST STS.
authors.affiliation: Institute of Clinical Medicine, University of Tromso, 9037 Tromso, Norway.
authors.forename: Eivind
authors.initials: E
authors.lastname: Smeland
authors.forename: Thomas K
authors.initials: TK
authors.lastname: Kilvaer
authors.forename: Sveinung
authors.initials: S
authors.lastname: Sorbye
authors.forename: Andrej
authors.initials: A
authors.lastname: Valkov
authors.forename: Sigve
authors.initials: S
authors.lastname: Andersen
authors.forename: Roy M
authors.initials: RM
authors.lastname: Bremnes
authors.forename: Lill-Tove
authors.initials: LT
authors.lastname: Busund
authors.forename: Tom
authors.initials: T
authors.lastname: Donnem