title: DAOA variants on diagnosis and response to treatment in patients with major depressive disorder and bipolar disorder.
abstract: OBJECTIVE
  This study investigated whether selected D-amino acid oxidase activator (DAOA) gene single nucleotide polymorphisms (SNPs; rs3916966, rs3916967, rs2391191, rs3916968, rs7139958, rs9558571, rs778293) are associated with major depressive disorder (MDD) and bipolar disorder  (BD), and whether they can predict clinical outcomes in Korean in-patients treated with antidepressants and mood stabilizers, respectively.
  
  
  METHODS
  In total, 145 patients with MDD, 132 patients with BD and 170 psychiatrically healthy controls were genotyped for the DAOA SNPs. Baseline  and final clinical assessments included the Montgomery-Asberg Depression Rating Scale and Young Mania Rating Scale for patients with MDD and BD, respectively.
  
  
  RESULTS
  There was no association between DAOA SNP genotypes or alleles with diagnosis, clinical improvement, response  rates or remission rates for MDD and BD. Haplotype analyses found no association with MDD or BD diagnosis or clinical outcomes.
  
  
  CONCLUSIONS
  The findings suggest that the DAOA SNPs investigated may not affect MDD or BD phenotype, clinical symptoms or other clinical factors, and are  unlikely to be involved in MDD or BD development and treatment outcomes. Given the study's limitations, further investigation should be carried out.
authors.affiliation: Institute of Psychiatry, University of Bologna, Bologna, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Chiesa
authors.forename: C-U
authors.initials: CU
authors.lastname: Pae
authors.forename: S
authors.initials: S
authors.lastname: Porcelli
authors.forename: C
authors.initials: C
authors.lastname: Han
authors.forename: S-J
authors.initials: SJ
authors.lastname: Lee
authors.forename: A A
authors.initials: AA
authors.lastname: Patkar
authors.forename: M H
authors.initials: MH
authors.lastname: Park
authors.forename: T-Y
authors.initials: TY
authors.lastname: Jun
authors.forename: A
authors.initials: A
authors.lastname: Serretti
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use; D044466:Asian People; D001714:Bipolar Disorder / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D016022:Case-Control Studies; D003865:Major Depressive Disorder / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D056910:Republic of Korea; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents; D002352:Carrier Proteins; C475071:DAOA protein, human; D047908:Intracellular Signaling Peptides and Proteins