title: The expanding role of miR-302-367 in pluripotency and reprogramming.
abstract: MicroRNA (miRNA) has been shown to be essential for regulating cell fate and pluripotency; however, our knowledge of miRNA function in stem cells is incomplete due to experimental limitations and difficulties in identifying their physiological targets. Recent studies implicated hESC-expressed miRNAs (miR‑302-367 and miR‑371-373 clusters) in regulating BMP signaling and promoting pluripotency, suggesting that low levels of BMP signaling may promote pluripotency by preventing neural induction. A comprehensive list of miR‑302-367 targets recently identified by genome-wide approaches suggests a number of additional cellular processes and signaling pathways whose regulation by miR‑302-367 may promote pluripotency and reprogramming, such as cell cycle, epigenetic changes, metabolism and vesicular transfer.
authors.affiliation: Developmental Biology Program, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
authors.forename: Inna
authors.initials: I
authors.lastname: Lipchina
authors.forename: Lorenz
authors.initials: L
authors.lastname: Studer
authors.forename: Doron
authors.initials: D
authors.lastname: Betel
mesh_terms: D000818:Animals; D001483:Base Sequence; D019485:Bone Morphogenetic Proteins / Q000378:metabolism; D002454:Cell Differentiation; D019070:Cell Lineage; D065150:Cellular Reprogramming; D053595:Embryonic Stem Cells / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D051379:Mice; D035683:MicroRNAs / Q000378:metabolism*; D009474:Neurons / Q000166:cytology; D015398:Signal Transduction; D016212:Transforming Growth Factor beta / Q000378:metabolism
chemical_list: D019485:Bone Morphogenetic Proteins; D035683:MicroRNAs; D016212:Transforming Growth Factor beta