title: Synthesis and in vitro anticancer and antitubercular activity of diarylpyrazole ligated dihydropyrimidines possessing lipophilic carbamoyl group.
abstract: A series of dihydropyrimidine derivatives were synthesized by utilizing Biginelli reaction and evaluated for their in vitro anticancer activity against MCF-7 human breast cancer (HBC) cell line using sulforhodamine B (SRB) assay and antitubercular activity against Mycobacterium tuberculosis (MTB) H(37)Rv using Microplate Alamar Blue Assay (MABA). Compounds 13p, 13t were exhibited 70.6% and 63.7% of HBC cell growth inhibition at 10 μM concentration. Interestingly compound 13p was also found to be the most potent in the series against MTB H(37)Rv with MIC value of 0.125 μg/mL.
authors.affiliation: Department of Chemistry, Dr. Harisingh Gour University (A Central University), Sagar, MP, India.
authors.forename: Rama Krishna
authors.initials: RK
authors.lastname: Yadlapalli
authors.forename: O P
authors.initials: OP
authors.lastname: Chourasia
authors.forename: Kiranmayi
authors.initials: K
authors.lastname: Vemuri
authors.forename: Manjula
authors.initials: M
authors.lastname: Sritharan
authors.forename: Ramu Sridhar
authors.initials: RS
authors.lastname: Perali
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D000995:Antitubercular Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001943:Breast Neoplasms / Q000188:drug therapy; D002219:Carbamates / Q000737:chemistry; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008055:Lipids / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D011720:Pyrazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D011743:Pyrimidines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D012995:Solubility
chemical_list: D000970:Antineoplastic Agents; D000995:Antitubercular Agents; D002219:Carbamates; D008055:Lipids; D011720:Pyrazoles; D011743:Pyrimidines