title: Evaluation of the hypocholesterolemic effect and phytochemical screening of the hydroethanolic extract of Crataegus aronia from Jordan.
abstract: Chemical screening of the leaves and flowers of Crataegus aronia resulted in the isolation of hyperoside, quercetin, rutin and beta-sitosterol for the first time from this plant. The effects of the hydroethanolic extract of C. aronia (CAHE) on hypercholesterolemic rats were investigated. The rats, treated orally for four weeks with 400 mg/kg/day CAHE, exhibited significant decreases in serum total cholesterol (TC) and low-density lipoprotein (LDL). The results were compared with those obtained after oral administration of atorvastatin (10 mg/kg/day). Furthermore, 10-week daily co-administration of a high cholesterol diet and CAHE (200 mg/kg/day) prevented the increase in TC and LDL. These observations indicate that CAHE has a hypocholesterolemic effect.
authors.affiliation: Department of Biological Sciences, Faculty of Science, University of Jordan, Amman 11942, Jordan.
authors.forename: Entisar K
authors.initials: EK
authors.lastname: Al-Hallaq
authors.forename: Fatma U
authors.initials: FU
authors.lastname: Afifi
authors.forename: Shtaywy S
authors.initials: SS
authors.lastname: Abdalla
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D027825:Crataegus / Q000737:chemistry*; D005260:Female; D007597:Jordan; D008055:Lipids / Q000097:blood; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000032:analysis / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000924:Anticholesteremic Agents; D008055:Lipids; D010936:Plant Extracts