title: Exercise training and impaired glucose tolerance in obese humans.
abstract: Individuals with impaired glucose tolerance (IGT) are at greater risk of developing diabetes than in normoglycaemia. The aim of this study was to examine the effects of 12-weeks exercise training in obese humans with IGT. Eleven participants (6 males and 5 females; 49±9 years; mean Body Mass Index (BMI) 32.4 kg · m(-2)), completed a 12-week brisk walking intervention (30 min per day, five days a week (d · wk(-1)), at 65% of age-predicted maximal heart rate (HR(max)). Anthropometric measurements, dietary intake, pulse wave velocity (PWV, to determine arterial stiffness) and blood pressure (BP) were examined at baseline and post intervention. Fasting blood glucose, glycosylated haemoglobin, insulin, blood lipids, indices of oxidative stress and inflammation (lipid hydroperoxides; superoxide dismutase; multimeric adiponectin concentration and high-sensitivity C-reactive protein) were also determined. Post intervention, PWV (9.08±1.27 m · s(-1) vs. 8.39±1.21 m · s(-1)), systolic BP (145.4±14.5 vs. 135.8±14.9 mmHg), triglycerides (1.52±0.53 mmol · L(-1) vs. 1.31±0.54 mmol · L(-1)), lipid hydroperoxides (1.20±0.47 μM · L(-1) vs. 0.79±0.32 μM · L(-1)) and anthropometric measures decreased significantly (P < 0.05). Moderate intensity exercise training improves upper limb vascular function in obese humans with IGT, possibly by improving triglyceride metabolism, which may subsequently reduce oxidative stress. These changes were independent of multimeric adiponectin modification and alterations in other blood biomarkers.
authors.affiliation: Sport and Exercise Sciences Research Institute, University of Ulster, Co. Antrim, United Kingdom.
authors.forename: Andrea Margaret
authors.initials: AM
authors.lastname: McNeilly
authors.forename: Conor
authors.initials: C
authors.lastname: McClean
authors.forename: Marie
authors.initials: M
authors.lastname: Murphy
authors.forename: Jane
authors.initials: J
authors.lastname: McEneny
authors.forename: Tom
authors.initials: T
authors.lastname: Trinick
authors.forename: George
authors.initials: G
authors.lastname: Burke
authors.forename: Ellie
authors.initials: E
authors.lastname: Duly
authors.forename: James
authors.initials: J
authors.lastname: McLaughlin
authors.forename: Gareth
authors.initials: G
authors.lastname: Davison
mesh_terms: D052242:Adiponectin / Q000097:blood / Q000502:physiology; D000328:Adult; D000886:Anthropometry; D001786:Blood Glucose / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis / Q000502:physiology; D005260:Female; D018149:Glucose Intolerance / Q000097:blood / Q000503:physiopathology*; D006442:Glycated Hemoglobin / Q000032:analysis / Q000502:physiology; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D007328:Insulin / Q000097:blood / Q000502:physiology; D008054:Lipid Peroxides / Q000097:blood / Q000502:physiology; D008055:Lipids / Q000097:blood / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000503:physiopathology*; D018384:Oxidative Stress / Q000502:physiology; D013482:Superoxide Dismutase / Q000097:blood / Q000502:physiology; D034941:Upper Extremity / Q000098:blood supply / Q000502:physiology; D059289:Vascular Stiffness / Q000502:physiology; D016138:Walking / Q000502:physiology*
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D002097:C-Reactive Protein; D006442:Glycated Hemoglobin; D007328:Insulin; D008054:Lipid Peroxides; D008055:Lipids; D013482:Superoxide Dismutase; C517652:hemoglobin A1c protein, human