title: Translational advances in pain and anesthesia for cancer patients.
abstract: Effective cancer pain management requires multidisciplinary approaches for multimodal analgesia. Although opioids have been the cornerstone, developments such as regional anesthesia and interventional pain techniques, complementary and alternative medicine, and new pharmaceuticals also have shown promise to relieve cancer pain. This overview of relevant clinical efforts and the modern day state of the science will afford a better understanding of pain mechanisms and multimodal approaches beneficial in optimizing analgesia for cancer patients.
authors.affiliation: Department of Anesthesia, United States Army Institute of Surgical Research, Fort Sam Houston, Texas, USA. christopher.maani@us.army.mil
authors.forename: Christopher V
authors.initials: CV
authors.lastname: Maani
authors.forename: Mohammad A
authors.initials: MA
authors.lastname: Shah
authors.forename: Jacob J
authors.initials: JJ
authors.lastname: Hansen
authors.forename: Marcie
authors.initials: M
authors.lastname: Fowler
authors.forename: Elizabeth V
authors.initials: EV
authors.lastname: Maani
authors.forename: Laura L
authors.initials: LL
authors.lastname: McGhee
mesh_terms: D000700:Analgesics / Q000494:pharmacology / Q000627:therapeutic use; D000758:Anesthesia / Q000379:methods* / Q000639:trends; D002908:Chronic Disease; D018389:Codon, Nonsense / Q000187:drug effects; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics; D015507:Drugs, Investigational / Q000494:pharmacology / Q000627:therapeutic use; D005838:Genotype; D006801:Humans; D062556:NAV1.7 Voltage-Gated Sodium Channel; D009369:Neoplasms / Q000150:complications* / Q000601:surgery*; D010146:Pain / Q000188:drug therapy* / Q000209:etiology / Q000235:genetics*; D059408:Pain Management / Q000379:methods* / Q000639:trends; D020641:Polymorphism, Single Nucleotide / Q000187:drug effects; D011788:Quality of Life; D015222:Sodium Channels / Q000235:genetics; D057170:Translational Research, Biomedical / Q000639:trends*
chemical_list: D000700:Analgesics; D018389:Codon, Nonsense; D015507:Drugs, Investigational; D062556:NAV1.7 Voltage-Gated Sodium Channel; C486866:SCN9A protein, human; D015222:Sodium Channels; D019389:Cytochrome P-450 CYP2D6