title: Corticosteroid treatment of idiopathic sudden sensorineural hearing loss:  randomized triple-blind placebo-controlled trial.
abstract: OBJECTIVE
  To compare the effect of Prednisolone and placebo on the recovery of unilateral idiopathic sudden sensorineural hearing loss.
  
  
  METHODS
  Prospective, randomized, triple-blind, placebo-controlled multicenter trial.
  
  
  METHODS
  Four tertiary and 10 secondary referral centers.
  
  
  METHODS
  Of 103 patients randomly assigned, 93 were included in the modified intention-to-treat analysis. The patients, aged 18 to 80 years, were seeking care within 1 week after onset of acute unilateral sensorineural hearing loss with a mean decrease of 30 dB or greater in the 3 most affected contiguous frequencies.
  
  
  METHODS
  Patients were randomly assigned in permuted blocks of 10 to receive Prednisolone or placebo in tapering doses from 60 mg for 3 days and, thereafter, 10 mg less each day until Day 8. If complete recovery, no more medication given, otherwise medication continued at 10 mg per day until Day 30. Final follow-up was after 3 months with audiogram; 47 patients received Prednisolone and 46 placebo.
  
  
  METHODS
  The primary endpoint was efficacy of treatment on recovery at Day 90. Secondary endpoints were prognostic factors for hearing recovery. Analyses were by modified intention-to-treat and per protocol.
  
  
  RESULTS
  Hearing improvement for 47 Prednisolone-treated patients was 25.5 ± 27.1 dB compared to 26.4 ± 26.2 dB for 46 placebo-treated patients at Day 8 and 39 ± 20.1 dB versus 35.1 ± 38.3 dB after 3 months. Vertigo had significant negative effect on hearing improvement and inflammatory signs in the laboratory workup-a positive prognostic effect, irrespective of treatment.
  
  
  CONCLUSIONS
  Prednisolone in customary dosage does not seem to influence recovery of idiopathic sudden sensorineural hearing loss.
authors.affiliation: Division of Otorhinolaryngology, Department of Clinical and Experimental Medicine, Medical Faculty, Linköping University, Linköping, Sweden.
authors.forename: Ramesh
authors.initials: R
authors.lastname: Nosrati-Zarenoe
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Hultcrantz
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use*; D006319:Hearing Loss, Sensorineural / Q000188:drug therapy*; D003639:Hearing Loss, Sudden / Q000188:drug therapy*; D006801:Humans; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D011446:Prospective Studies; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D005938:Glucocorticoids; D011239:Prednisolone