title: Bexsero: a multicomponent vaccine for prevention of meningococcal disease.
abstract: Serogroup B meningococcal (MenB) disease remains a serious public health problem for which a cross-protective vaccine effective against a wide range of MenB isolates has not been available. Novartis Vaccines has developed a vaccine for the prevention of MenB disease that contains four antigenic components: factor H binding protein (fHbp), neisserial adhesin A (NadA), Neisseria heparin binding antigen (NHBA) and outer membrane vesicles from a New Zealand epidemic strain (which provides PorA). This vaccine has been submitted for regulatory review in Europe so it is timely to review the design of the vaccine, results to date in clinical studies and the potential strain coverage provided by the vaccine. It is also critical to discuss the key issues for the long-term success of the vaccine which include strain coverage, potential persistence of protection, potential effects on carriage of MenB strains, potential for escape mutants and cost effectiveness.
authors.affiliation: Health Protection Agency, Porton Down, Salisbury UK. Andrew.gorringe@hpa.org.uk
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Gorringe
authors.forename: Rolando
authors.initials: R
authors.lastname: Pajón
mesh_terms: D018829:Adhesins, Bacterial / Q000276:immunology; D000942:Antigens, Bacterial / Q000276:immunology; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology; D001426:Bacterial Proteins / Q000276:immunology; D056738:Cross Protection; D006801:Humans; D008585:Meningitis, Meningococcal / Q000276:immunology* / Q000517:prevention & control*; D022401:Meningococcal Vaccines / Q000276:immunology*; D018272:Porins / Q000276:immunology; D016032:Randomized Controlled Trials as Topic
chemical_list: D018829:Adhesins, Bacterial; D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D022401:Meningococcal Vaccines; C501982:NadA protein, Neisseria meningitidis; D018272:Porins; C484699:factor H-binding protein, Neisseria meningitidis; C057699:porin protein, Neisseria