title: Histone-modifying enzymes: regulators of developmental decisions and drivers of human disease.
abstract: Precise transcriptional networks drive the orchestration and execution of complex developmental processes. Transcription factors possessing sequence-specific DNA binding properties activate or repress target genes in a step-wise manner to control most cell lineage decisions. This regulation often requires the interaction between transcription factors and subunits of massive protein complexes that bear enzymatic activities towards histones. The functional coupling of transcription proteins and histone modifiers underscores the importance of transcriptional regulation through chromatin modification in developmental cell fate decisions and in disease pathogenesis.
authors.affiliation: Department of Molecular Carcinogenesis at The Virginia Harris Cockrell Cancer Research Center, University of Texas MD Anderson Cancer Center Science Park, PO Box 389, Smithville, TX 78957, USA.
authors.forename: Jill S
authors.initials: JS
authors.lastname: Butler
authors.forename: Evangelia
authors.initials: E
authors.lastname: Koutelou
authors.forename: Andria C
authors.initials: AC
authors.lastname: Schibler
authors.forename: Sharon Y R
authors.initials: SY
authors.lastname: Dent
mesh_terms: D002843:Chromatin / Q000378:metabolism; D019175:DNA Methylation; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D006655:Histone Deacetylases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D056466:Histone Demethylases / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D006657:Histones / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D056484:Jumonji Domain-Containing Histone Demethylases / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism*; D009154:Mutation; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology / Q000473:pathology; D000099186:Histone Deacetylase 3
chemical_list: D002843:Chromatin; D004791:Enzyme Inhibitors; D006655:Histone Deacetylases; D056466:Histone Demethylases; D006657:Histones; D056484:Jumonji Domain-Containing Histone Demethylases; D000099186:Histone Deacetylase 3