title: Novel molecular screening approaches in colorectal cancer.
abstract: Traditional methods for colorectal cancer (CRC) screening have reduced rates of malignancy and death; however, low compliance and morbidities associated with invasive techniques have encouraged efforts for establishing equally effective, less invasive novel screening approaches. We review the current state of novel screening approaches in CRC to include CT colonography, fecal DNA, DNA methylation, micro-RNA, and protein and molecular markers.
authors.affiliation: Department of General Surgery, Madigan Army Medical Center, Tacoma, Washington 98431, USA.
authors.forename: Seth
authors.initials: S
authors.lastname: Miller
authors.forename: Scott
authors.initials: S
authors.lastname: Steele
mesh_terms: D023881:Colonography, Computed Tomographic; D003113:Colonoscopy / Q000009:adverse effects; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics*; D019175:DNA Methylation; D004273:DNA, Neoplasm / Q000032:analysis; D015536:Down-Regulation; D055088:Early Detection of Cancer; D044127:Epigenesis, Genetic; D005243:Feces / Q000737:chemistry; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008403:Mass Screening / Q000009:adverse effects / Q000379:methods*; D035683:MicroRNAs / Q000378:metabolism; D009367:Neoplasm Staging; D009780:Occult Blood; D012680:Sensitivity and Specificity; D057170:Translational Research, Biomedical / Q000639:trends; D014481:United States / Q000453:epidemiology
chemical_list: D004273:DNA, Neoplasm; D035683:MicroRNAs