title: Synthesis of 4-hydroxy-3,4-dialkyl-2,6-diaryl-piperidine derivatives as potent antimicrobial agent.
abstract: A series of 4-hydroxy-3,4-dialkyl-2,6-diaryl-piperidine (7-12) have been synthesised by reduction of 3-alkyl-2,6-diarylpiperidin-4-one using the Grignard reagent. Structural assignments and conformational analysis of the compounds were established based on the spectral studies. All the piperdin-4-ol derivatives (7-12) were assayed for antibacterial, antifungal and anthelmintic activities and they exhibited significant results.
authors.affiliation: Department of Chemistry, Sona College of Technology, Salem-636005, Tamil Nadu, India.
authors.forename: T
authors.initials: T
authors.lastname: Maruthavanan
authors.forename: P
authors.initials: P
authors.lastname: Venkatesan
mesh_terms: D000871:Anthelmintics / Q000138:chemical synthesis / Q000737:chemistry; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010880:Piperidines / Q000138:chemical synthesis* / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000871:Anthelmintics; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D010880:Piperidines; C032727:piperidine