title: Clinical epidemiology, management and outcome of acute coronary syndromes in the Italian network on acute coronary syndromes (IN-ACS Outcome study).
abstract: BACKGROUND
  The Italian network on acute coronary syndromes outcome (IN-ACS Outcome) study is a nationwide observational, multicenter study with the aim to describe clinical epidemiology, management, 30-days and one-year outcomes of ACS in Italy.
  
  
  METHODS
  All consecutive patients admitted for ACS to 38 hospitals, between December 2005 and February 2007, were enrolled in the study. Patient in-hospital details and follow-up data at 30-days and one-year were collected using a web-based CRF and stored in a central database.
  
  
  RESULTS
  A total of 6045 patients (age 68 ± 13 years) were enrolled: 2313 patients (38.3%) had ST elevation myocardial infarction (STEMI) and 3732 (61.7%) patients had NSTE-ACS. Primary PCI was performed in 1085 (46.9%) STEMI patients, thrombolysis in 590 (25.5%) patients, whereas 638 (27.6%) patients were not reperfused. Among patients with NSTE-ACS, coronary angiography was performed in 2797 (75%) patients, PCI in 1797 (48.2%) patients and CABG in 213 (5.7%) patients. Thirty-days and one-year mortality rates were 5.8% and 9.8%, in STEMI patients and 3.1% and 8.6%, in NSTE-ACS patients.
  
  
  CONCLUSIONS
  The IN-ACS Outcome study showed that the management of ACS is still suboptimal. Although 30-days mortality is low, the one-year mortality is still substantial.
authors.affiliation: San Giovanni-Addolorata Hospital, Department of Cardiology, Rome, Italy. centrostudi@anmco.it
authors.forename: Vittoria
authors.initials: V
authors.lastname: Rizzello
authors.forename: Donata
authors.initials: D
authors.lastname: Lucci
authors.forename: Aldo P
authors.initials: AP
authors.lastname: Maggioni
authors.forename: Simona
authors.initials: S
authors.lastname: Giampaoli
authors.forename: Cesare
authors.initials: C
authors.lastname: Greco
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Di Pasquale
authors.forename: Maria Giovanna
authors.initials: MG
authors.lastname: Pallotti
authors.forename: Gian Francesco
authors.initials: GF
authors.lastname: Mureddu
authors.forename: Antonio
authors.initials: A
authors.lastname: Di Chiara
authors.forename: Alessandro
authors.initials: A
authors.lastname: Boccanelli
mesh_terms: D054058:Acute Coronary Syndrome / Q000175:diagnosis / Q000401:mortality* / Q000628:therapy; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D015906:Angioplasty, Balloon, Coronary; D001026:Coronary Artery Bypass; D019468:Disease Management; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007558:Italy / Q000453:epidemiology; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000401:mortality* / Q000628:therapy; D015425:Myocardial Reperfusion / Q000706:statistics & numerical data*; D019370:Observation; D016016:Proportional Hazards Models; D012042:Registries; D012306:Risk; D016896:Treatment Outcome