title: Biomarker discovery by novel sensors based on nanoproteomics approaches.
abstract: During the last years, proteomics has facilitated biomarker discovery by coupling high-throughput techniques with novel nanosensors. In the present review, we focus on the study of label-based and label-free detection systems, as well as nanotechnology approaches, indicating their advantages and applications in biomarker discovery. In addition, several disease biomarkers are shown in order to display the clinical importance of the improvement of sensitivity and selectivity by using nanoproteomics approaches as novel sensors.
authors.affiliation: Centro de Investigación del Cáncer/IBMCC (USAL/CSIC), Departamento de Medicina and Servicio General de Citometría, University of Salamanca, Salamanca 37007, Spain. noeliadf@usal.es
authors.forename: Noelia
authors.initials: N
authors.lastname: Dasilva
authors.forename: Paula
authors.initials: P
authors.lastname: Díez
authors.forename: Sergio
authors.initials: S
authors.lastname: Matarraz
authors.forename: María
authors.initials: M
authors.lastname: González-González
authors.forename: Sara
authors.initials: S
authors.lastname: Paradinas
authors.forename: Alberto
authors.initials: A
authors.lastname: Orfao
authors.forename: Manuel
authors.initials: M
authors.lastname: Fuentes
mesh_terms: D015415:Biomarkers / Q000032:analysis*; D015374:Biosensing Techniques; D004867:Equipment Design; D019544:Equipment Failure Analysis; D036103:Nanotechnology / Q000295:instrumentation*; D040081:Protein Array Analysis / Q000295:instrumentation*; D040901:Proteomics / Q000295:instrumentation*; D014159:Transducers
chemical_list: D015415:Biomarkers