title: Genetics of ion-channel disorders.
abstract: OBJECTIVE
  In this article, we summarize the main features of the most common inherited channelopathies, focusing on the findings that advanced the field in the last few years.
  
  
  RESULTS
  The progress in genetics prompted the discovery of several new genes associated with ion-channel disorders, elucidating new molecular pathways and new arrhythmogenic mechanisms. The diffusion and availability of genetic screening gave a new relevance to the application of genetics not only for diagnosis, but also for risk assessment and therapeutic decisions. As a consequence, the present challenge in the field is represented by the need to use genetic data to develop personalized clinical approaches.
  
  
  CONCLUSIONS
  Over a few years, the field of inherited arrhythmogenic diseases has rapidly expanded, thus reshaping clinical management for these conditions. It is now clear that to handle these patients a specialized expertise is needed, able to translate the discoveries derived from basic science studies into the clinical care of the patients.
authors.affiliation: Leon H. Charney Division of Cardiology, New York University, New York, New York, USA.
authors.forename: Marina
authors.initials: M
authors.lastname: Cerrone
authors.forename: Carlo
authors.initials: C
authors.lastname: Napolitano
authors.forename: Silvia G
authors.initials: SG
authors.lastname: Priori
mesh_terms: D053840:Brugada Syndrome / Q000235:genetics; D053447:Channelopathies / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008133:Long QT Syndrome / Q000453:epidemiology / Q000235:genetics*; D032383:Myocytes, Cardiac; D010641:Phenotype; D015221:Potassium Channels / Q000235:genetics*; D018570:Risk Assessment / Q000379:methods; D017180:Tachycardia, Ventricular / Q000235:genetics
chemical_list: D015221:Potassium Channels