title: LRRK2 as a modulator of lysosomal calcium homeostasis with downstream effects on autophagy.
abstract: Alterations in autophagy are thought to underlie various neurodegenerative diseases including Parkinson disease (PD). Previous studies have indicated that the PD gene leucine rich repeat kinase 2 (LRRK2) is involved in this process, but its mechanism of action has remained unknown. Our recent work describes how LRRK2 acts through calcium-mediated events originating from acidic stores to regulate autophagy and cell survival, which may give rise to novel therapeutic strategies.
authors.affiliation: Institute of Parasitology and Biomedicine López-Neyra, Consejo Superior de Investigaciones Cientificas (CSIC), Granada, Spain.
authors.forename: Patricia
authors.initials: P
authors.lastname: Gómez-Suaga
authors.forename: Sabine
authors.initials: S
authors.lastname: Hilfiker
mesh_terms: D000818:Animals; D001343:Autophagy; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000378:metabolism; D002470:Cell Survival; D004331:Drosophila melanogaster / Q000201:enzymology; D006706:Homeostasis; D008247:Lysosomes / Q000378:metabolism*; D008954:Models, Biological; D009249:NADP / Q000031:analogs & derivatives / Q000378:metabolism; D010588:Phagosomes / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D015220:Calcium Channels; D009249:NADP; C024376:NAADP; D017346:Protein Serine-Threonine Kinases; D002118:Calcium