title: The effect of left ventricular (LV) remodeling on ventricular arrhythmia in cardiac resynchronization therapy (CRT-D) patients (antiarrhythmic effect of CRT).
abstract: BACKGROUND
  In patients with low ejection fraction and ventricular dyssynchrony, cardiac resynchronization therapy (CRT) is an accepted therapeutic modality. In these patients, CRT can improve the quality of life and exercise tolerance in addition to improved survival. On the other hand, antiarrhythmic effects of CRT is a place of debate.
  
  
  METHODS
  In this study, we evaluated the effect of CRT-induced reverse remodeling on ventricular arrhythmia in heart failure patients. Patients with CRT were divided to two groups of responders and nonresponders. Responders were those with reduction of LVESD of more than 10% or increase in LVEF of more than 5%. They were visited and device analysis was performed during the follow-up.
  
  
  RESULTS
  One hundred and nineteen patients were enrolled in this study. Those with reverse remodeling experienced fewer ventricular arrhythmias after two years of follow-up (N = 2 vs 11, P = 0.001).
  
  
  CONCLUSIONS
  Reverse remodeling associated with CRT implantation can result in decreased frequency of ventricular arrhythmias.
authors.affiliation: Electrophysiology Department, Shaheed Rajaei Cardiovascular Medical and Research Center, Tehran, Iran.
authors.forename: Shahab
authors.initials: S
authors.lastname: Shahrzad
authors.forename: Nozad Karim
authors.initials: NK
authors.lastname: Soleiman
authors.forename: Samira
authors.initials: S
authors.lastname: Taban
authors.forename: Abolfath
authors.initials: A
authors.lastname: Alizadeh
authors.forename: Amir
authors.initials: A
authors.lastname: Aslani
authors.forename: Amir
authors.initials: A
authors.lastname: Tavoosi
authors.forename: Zahra
authors.initials: Z
authors.lastname: Emkanjoo
mesh_terms: D000368:Aged; D058406:Cardiac Resynchronization Therapy / Q000706:statistics & numerical data*; D015897:Comorbidity; D005260:Female; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008297:Male; D015995:Prevalence; D018570:Risk Assessment; D012307:Risk Factors; D013318:Stroke Volume; D017180:Tachycardia, Ventricular / Q000453:epidemiology* / Q000517:prevention & control*; D016896:Treatment Outcome; D018487:Ventricular Dysfunction, Left / Q000453:epidemiology* / Q000517:prevention & control*; D020257:Ventricular Remodeling