title: Putative multifunctional signature of lung metastases in dedifferentiated chondrosarcoma.
abstract: Chondrosarcomas are among the most malignant skeletal tumors. Dedifferentiated chondrosarcoma is a highly aggressive subtype of chondrosarcoma, with lung metastases developing within a few months of diagnosis in 90% of patients. In this paper we performed comparative analyses of the transcriptomes of five individual metastatic lung lesions that were surgically resected from a patient with dedifferentiated chondrosarcoma. We document for the first time a high heterogeneity of gene expression profiles among the individual lung metastases. Moreover, we reveal a signature of "multifunctional" genes that are expressed in all metastatic lung lesions. Also, for the first time, we document the occurrence of massive macrophage infiltration in dedifferentiated chondrosarcoma lung metastases.
authors.affiliation: Cancer Biology and Epigenomics Program, Children's Memorial Research Center, and Department of Pediatrics, Northwestern University Feinberg School of Medicine, 2430 N. Halstead Street, Chicago, IL 60614, USA.
authors.forename: Sergey
authors.initials: S
authors.lastname: Malchenko
authors.forename: Elisabeth A
authors.initials: EA
authors.lastname: Seftor
authors.forename: Yuri
authors.initials: Y
authors.lastname: Nikolsky
authors.forename: Susan L
authors.initials: SL
authors.lastname: Hasegawa
authors.forename: Sean
authors.initials: S
authors.lastname: Kuo
authors.forename: Jeff W
authors.initials: JW
authors.lastname: Stevens
authors.forename: Stas
authors.initials: S
authors.lastname: Poyarkov
authors.forename: Tatiana
authors.initials: T
authors.lastname: Nikolskaya
authors.forename: Tamara
authors.initials: T
authors.lastname: Kucaba
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.forename: Hakim
authors.initials: H
authors.lastname: Abdulkawy
authors.forename: Thomas
authors.initials: T
authors.lastname: Casavant
authors.forename: Jose
authors.initials: J
authors.lastname: Morcuende
authors.forename: Joseph
authors.initials: J
authors.lastname: Buckwalter
authors.forename: Raymond
authors.initials: R
authors.lastname: Hohl
authors.forename: Barry
authors.initials: B
authors.lastname: Deyoung
authors.forename: Kemp
authors.initials: K
authors.lastname: Kernstine
authors.forename: Maria de Fatima
authors.initials: Mde F
authors.lastname: Bonaldo
authors.forename: Mary J C
authors.initials: MJ
authors.lastname: Hendrix
authors.forename: Marcelo B
authors.initials: MB
authors.lastname: Soares
authors.forename: Vera Maria F C
authors.initials: VM
authors.lastname: Soares