title: Two new triterpenoid saponins from the husks of Xanthoceras sorbifolia.
abstract: Two new oleanane triterpenoid saponins, xanthohuskisides A (1) and B (2), were isolated from the husks of Xanthoceras sorbifolia. The structures of these two compounds were established as 3-O-β-D-glucopyranosyl (1→6)-[β-D-glucopyranosyl (1→2)]-β-D-glucopyranosyl, 28-O-β-D-glucopyranosyl (1→6)-[α-L-rhamnopyranosyl (1→2)]-β-D-glucopyranosyl 16-deoxybarringtogenol C (1) and 3-O-β-D-glucopyranosyl (1→6)-[β-D-glucopyranosyl (1→2)]-β-D-glucopyranosyl, 28-O-β-D-glucopyranosyl (1→6)-β-D-glucopyranosyl 16-deoxybarringtogenol C (2), respectively, based on the analysis on their spectral data including NMR and HR-ESI-MS. The growth inhibitory activities of compounds 1 and 2 were assayed, and 2 showed moderate activity against U937 cell line with the IG(50) value of 82.85 ± 1.58 µM.
authors.affiliation: Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China. lizhanlin1030@yahoo.com.cn
authors.forename: Zhan-Lin
authors.initials: ZL
authors.lastname: Li
authors.forename: Dan-Yi
authors.initials: DY
authors.lastname: Li
authors.forename: Xiao-Meng
authors.initials: XM
authors.lastname: He
authors.forename: Hui-Ming
authors.initials: HM
authors.lastname: Hua
mesh_terms: D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry; D029631:Sapindaceae / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry* / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D012503:Saponins; C413246:oleanane; D009828:Oleanolic Acid