title: Elevated red cell distribution width is associated with impaired reverse ventricular remodeling and increased mortality in patients undergoing cardiac resynchronization therapy.
abstract: Elevated red cell distribution width (RDW) has been associated with poor long-term outcomes in patients with systolic dysfunction. The relationship between baseline RDW and reverse ventricular remodeling in advanced heart failure patients undergoing cardiac resynchronization therapy (CRT) has not been established. The authors reviewed the pre-implant and follow-up echocardiograms of 233 patients undergoing the new implantation of a CRT device at the Cleveland Clinic between December 2001 and November 2006. Patients were included in the final cohort if they had an RDW level within 7 days of CRT implantation, a left ventricular ejection fraction (LVEF) ≤40%, and New York Heart Association class II to IV symptoms. Patients with a reduction in left ventricular end-systolic volume ≥15% following CRT were considered "responders." Multivariate models were created to assess the relationship between baseline RDW elevation with progressive remodeling and all-cause mortality. Of 233 patients, 217 patients met inclusion criteria. Patients in the highest RDW quartile (>16.1) derived significantly less improvement in LVEF (3.5%±9.3% vs 10.1%±10.9%, P=.001) than patients in the lowest quartile (<13.6). In multivariate analysis, elevated RDW was inversely associated with response (odds ratio, 0.83; 95% confidence interval, 0.69-0.99; P=.047). The presence of elevated RDW is associated with less reverse left ventricular remodeling in patients with advanced heart failure undergoing CRT.
authors.affiliation: Department of Cardiovascular Medicine, Cleveland Clinic, Cleveland, OH 44195, USA.
authors.forename: John
authors.initials: J
authors.lastname: Rickard
authors.forename: Dharam J
authors.initials: DJ
authors.lastname: Kumbhani
authors.forename: Eiran Z
authors.initials: EZ
authors.lastname: Gorodeski
authors.forename: David O
authors.initials: DO
authors.lastname: Martin
authors.forename: Richard A
authors.initials: RA
authors.lastname: Grimm
authors.forename: Patrick
authors.initials: P
authors.lastname: Tchou
authors.forename: Bruce D
authors.initials: BD
authors.lastname: Lindsay
authors.forename: W H
authors.initials: WH
authors.lastname: Tang
authors.forename: Bruce L
authors.initials: BL
authors.lastname: Wilkoff
mesh_terms: D058406:Cardiac Resynchronization Therapy / Q000379:methods*; D016001:Confidence Intervals; D004912:Erythrocytes / Q000473:pathology*; D005260:Female; D054143:Heart Failure, Systolic / Q000000981:diagnostic imaging / Q000401:mortality / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D009820:Ohio; D012189:Retrospective Studies; D018570:Risk Assessment / Q000379:methods; D013223:Statistics as Topic; D018709:Statistics, Nonparametric; D013997:Time Factors; D014463:Ultrasonography; D020257:Ventricular Remodeling