title: Diffuse large B-cell lymphoma arising primarily at the stoma after bladder reconstruction using ileal conduit.
abstract: A 76-year-old man suffered from swelling stoma for several weeks. A biopsy sample revealed the diffuse infiltration of large lymphoid cells which were positive for CD20, bcl-6, and MUM1. The patient was diagnosed with diffuse large B-cell lymphoma, with a non-germinal center B-cell pattern. A whole-body PET-CT scan revealed that the lymphoma was restricted to the stomal site. Bladder reconstruction was undertaken using the ileal conduit: this is the first reported case of lymphoma that developed primarily at the stoma. During the long-term maintenance after bladder reconstruction, clinicians should consider the possibility of lymphoma at the stomal site.
authors.affiliation: Department of Internal Medicine, Chihaya Hospital, Japan. muta0621@gmail.com
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Muta
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakaike
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Fujisaki
authors.forename: Takeshi
authors.initials: T
authors.lastname: Shiraishi
authors.forename: Koichi
authors.initials: K
authors.lastname: Ohshima
mesh_terms: D000368:Aged; D018951:Antigens, CD20 / Q000032:analysis; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D002295:Carcinoma, Transitional Cell / Q000601:surgery; D003520:Cyclophosphamide / Q000008:administration & dosage; D004268:DNA-Binding Proteins / Q000032:analysis; D004317:Doxorubicin / Q000008:administration & dosage / Q000031:analogs & derivatives; D006801:Humans; D050835:Interferon Regulatory Factors / Q000032:analysis; D016403:Lymphoma, Large B-Cell, Diffuse / Q000737:chemistry / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D016609:Neoplasms, Second Primary / Q000737:chemistry / Q000209:etiology*; D011183:Postoperative Complications / Q000188:drug therapy / Q000209:etiology*; D011239:Prednisolone / Q000008:administration & dosage; D051560:Proto-Oncogene Proteins c-bcl-6; D012074:Remission Induction; D054047:Surgical Stomas / Q000473:pathology*; D001749:Urinary Bladder Neoplasms / Q000601:surgery; D014547:Urinary Diversion; D014750:Vincristine / Q000008:administration & dosage; D000099218:Interferon Regulatory Factor-4
chemical_list: D018951:Antigens, CD20; D014408:Biomarkers, Tumor; D003520:Cyclophosphamide; D004268:DNA-Binding Proteins; D004317:Doxorubicin; D050835:Interferon Regulatory Factors; D011239:Prednisolone; D051560:Proto-Oncogene Proteins c-bcl-6; D014750:Vincristine; D000099218:Interferon Regulatory Factor-4; C084103:BCL6 protein, human