title: New bronchodilators.
abstract: Bronchodilators are central in the treatment of airway diseases including chronic obstructive pulmonary disease (COPD). Bronchodilators in COPD aim to improve lung function, reduce symptoms, prevent exacerbation, and enhance quality of life. The majority of programs in development for novel bronchodilators are focused on enhancing existing targets to once daily dosing and improving their safety profiles. However, just as important are other programs that aim to discover novel pharmacologic targets such as EP4 receptor agonists, bitter taste receptors, and selective PDE inhibitors. Furthermore, existing and novel bronchodilators have become vital components of multiple combination therapies targeting COPD. This review will discuss emerging bronchodilators highlighting preclinical data and available clinical trials.
authors.affiliation: Section of Pulmonary, Critical Care and Sleep Medicine, Baylor College of Medicine, Houston, TX, United States.
authors.forename: Garbo
authors.initials: G
authors.lastname: Mak
authors.forename: Nicola A
authors.initials: NA
authors.lastname: Hanania
mesh_terms: D058666:Adrenergic beta-2 Receptor Agonists / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D001993:Bronchodilator Agents / Q000494:pharmacology / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D015507:Drugs, Investigational / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D058990:Molecular Targeted Therapy; D018727:Muscarinic Antagonists / Q000494:pharmacology / Q000627:therapeutic use; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy* / Q000378:metabolism; D043562:Receptors, G-Protein-Coupled / Q000037:antagonists & inhibitors / Q000378:metabolism; D058309:Receptors, Prostaglandin E, EP4 Subtype / Q000037:antagonists & inhibitors / Q000378:metabolism; D000098706:Taste Receptors, Type 2
chemical_list: D058666:Adrenergic beta-2 Receptor Agonists; D001993:Bronchodilator Agents; D015507:Drugs, Investigational; D018727:Muscarinic Antagonists; D010726:Phosphodiesterase Inhibitors; D043562:Receptors, G-Protein-Coupled; D058309:Receptors, Prostaglandin E, EP4 Subtype; C431926:taste receptors, type 1; D000098706:Taste Receptors, Type 2