title: [Ear, nose and throat manifestations of Wegener's granulomatosis (granulomatosis with polyangiitis)].
abstract: OBJECTIVE
  Granulomatosis with polyangiitis (GPA), previously called Wegener's granulomatosis, is a small vessel vasculitis often associated with clinical head and neck manifestations, which are sometimes the presenting symptoms of the disease. The aim of our study was to identify ear, nose and throat (ENT) manifestations associated with GPA and propose a work-up for the management and diagnosis for patients with suspicion or confirmed diagnosis of this ENT pathology.
  
  
  METHODS
  Retrospective review of the medical records of all patients diagnosed with GPA who were seen at the Department of Otolaryngology from a tertiary public hospital in Cantabria (Spain) over a 20-year period. Clinical and laboratory data, in particular those concerning ENT manifestations, were retrieved from the patients' medical records.
  
  
  RESULTS
  Twenty-five patients (age range: 30-81 years) were included in the study. Of these, 88% had ENT manifestations at some point in the course of the disease. In 28% of the cases, ENT features were the presenting manifestations. The most frequent ENT manifestations were sinonasal symptoms (52%), followed by otological manifestations (32%).
  
  
  CONCLUSIONS
  Patients with GPA often present with clinical ENT manifestations. Consequently, routine ENT physical examination must be performed in patients with suspected vasculitis to establish a diagnosis of GPA or to better determine the degree of organ system involvement in patients with GPA.
authors.affiliation: Otorrinolaringología, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, España.
authors.forename: Carmelo
authors.initials: C
authors.lastname: Morales-Angulo
authors.forename: Roberto
authors.initials: R
authors.lastname: García-Zornoza
authors.forename: Sergio
authors.initials: S
authors.lastname: Obeso-Agüera
authors.forename: Jaime
authors.initials: J
authors.lastname: Calvo-Alén
authors.forename: Miguel A
authors.initials: MA
authors.lastname: González-Gay
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood; D001324:Autoantigens / Q000276:immunology; D018450:Disease Progression; D005260:Female; D005921:Glomerulonephritis / Q000453:epidemiology / Q000209:etiology; D014890:Granulomatosis with Polyangiitis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000276:immunology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D053146:Myeloblastin / Q000276:immunology; D010038:Otorhinolaryngologic Diseases / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D009195:Peroxidase / Q000276:immunology; D010808:Physical Examination; D012189:Retrospective Studies; D013030:Spain / Q000453:epidemiology
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D001324:Autoantigens; D007166:Immunosuppressive Agents; D009195:Peroxidase; D053146:Myeloblastin