title: Bark extract of Bathysa cuspidata attenuates extra-pulmonary acute lung injury induced by paraquat and reduces mortality in rats.
abstract: This study investigated the effect of the bark extract of Bathysa cuspidata on paraquat (PQ)-induced extra-pulmonary acute lung injury (ALI) and mortality in rats. ALI was induced with a single dose of PQ (30 mg/kg, i.p.), and animals were treated with B. cuspidata extract (200 and 400 mg/kg). Analyses were conducted of survival, cell migration, lung oedema, malondialdehyde, proteins carbonyls, catalase, superoxide dismutase, histopathology and the stereology of lung tissue. Rats exposed to PQ and treated with 200 and 400 mg of the extract presented lower mortality (20% and 30%), compared with PQ alone group (50%). Furthermore, lung oedema, septal thickening, alveolar collapse, haemorrhage, cell migration, malondialdehyde and proteins carbonyl levels decreased, and catalase and superoxide dismutase activity were maintained. These results show that the bark extract of B. cuspidata reduced PQ-induced extra-pulmonary ALI and mortality in rats and suggest that these effects may be associated with the inhibition of oxidative damage.
authors.affiliation: Department of General Biology, Federal University of Viçosa, Viçosa, Minas Gerais, Brazil. romuonovaes@yahoo.com.br
authors.forename: Rômulo D
authors.initials: RD
authors.lastname: Novaes
authors.forename: Reggiani V
authors.initials: RV
authors.lastname: Gonçalves
authors.forename: Marli C
authors.initials: MC
authors.lastname: Cupertino
authors.forename: Daiane C S
authors.initials: DC
authors.lastname: Marques
authors.forename: Damiana D
authors.initials: DD
authors.lastname: Rosa
authors.forename: Maria do Carmo G
authors.initials: Mdo C
authors.lastname: Peluzio
authors.forename: Clóvis A
authors.initials: CA
authors.lastname: Neves
authors.forename: João Paulo V
authors.initials: JP
authors.lastname: Leite
mesh_terms: D055371:Acute Lung Injury / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000401:mortality; D000818:Animals; D002374:Catalase / Q000378:metabolism; D002465:Cell Movement / Q000187:drug effects; D006540:Herbicides / Q000633:toxicity*; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D010269:Paraquat / Q000633:toxicity*; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D011654:Pulmonary Edema / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism / Q000401:mortality; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D006540:Herbicides; D010936:Plant Extracts; D008315:Malondialdehyde; D002374:Catalase; D013482:Superoxide Dismutase; D010269:Paraquat