title: Impact of a resistant dextrin on intestinal ecology: how altering the digestive ecosystem with NUTRIOSE®, a soluble fibre with prebiotic properties, may be beneficial for health.
abstract: OBJECTIVE
  The prebiotic potential of NUTRIOSE®--a sugar-free, digestion-resistant dextrin--was evaluated in two randomized, placebo-controlled trials that included 48 and 40 healthy volunteers, respectively.
  
  
  METHODS
  In study 1, the effect on colonic bacteria of NUTRIOSE® 10, 15 or 20 g/day administered for 14 days was examined; in study 2, gut microbial changes in response to NUTRIOSE® 8 g/day for 14 days were monitored using real-time polymerase chain reaction analysis.
  
  
  RESULTS
  NUTRIOSE® increased proliferation of Bacteroides and inhibited Clostridum perfringens in both studies, increased β-glucosidase activity (at 10 and 15 g/day) and decreased colonic pH (at 20 g/day). The increase in short-chain fatty acid production with NUTRIOSE® consumption was not statistically significant. There were no indications of gastrointestinal intolerance at any dose.
  
  
  CONCLUSIONS
  According to commonly accepted definitions, NUTRIOSE® is a prebiotic soluble fibre that provides a beneficial effect on colonic ecology while preserving digestive comfort.
authors.affiliation: Nutrition Direction, Roquette, 62080 Lestrem, France. catherine.lefranc@roquette.com
authors.forename: C
authors.initials: C
authors.lastname: Lefranc-Millot
authors.forename: L
authors.initials: L
authors.lastname: Guérin-Deremaux
authors.forename: D
authors.initials: D
authors.lastname: Wils
authors.forename: C
authors.initials: C
authors.lastname: Neut
authors.forename: L E
authors.initials: LE
authors.lastname: Miller
authors.forename: M H
authors.initials: MH
authors.lastname: Saniez-Degrave
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001439:Bacteroides / Q000187:drug effects / Q000254:growth & development; D003016:Clostridium perfringens / Q000187:drug effects; D015169:Colony Count, Microbial; D003912:Dextrins / Q000008:administration & dosage / Q000494:pharmacology*; D004043:Dietary Fiber; D005243:Feces / Q000382:microbiology; D005260:Female; D006262:Health; D006801:Humans; D006863:Hydrogen-Ion Concentration / Q000187:drug effects; D007422:Intestines / Q000187:drug effects* / Q000382:microbiology*; D008297:Male; D008875:Middle Aged; D056692:Prebiotics; D012995:Solubility / Q000187:drug effects
chemical_list: D003912:Dextrins; D004043:Dietary Fiber; C573352:NUTRIOSE; D056692:Prebiotics