title: Changes in neurons of medulla oblongata nuclei under conditions of chronic NO-synthase inhibition.
abstract: Nucleus tractus solitarius and giant-cell and lateral reticular nuclei were studied using the reaction to NADPH-diaphorase in 7-, 10-, 14-, 30-, 45-, 60-day-and 3- and 6-month-old rats receiving L-NAME (50 μg/kg, 2 times a day) on days 1-6 of life. In 7-14-day-old rats, the compound reduced NO-synthase activity in the majority of NO-neurons and the total number and to a lesser degree the relative number of these neurons, while cell cross-section areas remained practically unchanged. The differences in the corresponding quantitative parameters between the control (D-NAME administration) and experimental groups decreased with time after the last L-NAME injection and became undetectable starting from the age of 30-45 days. In the nucleus tractus solitarius, the changes in metric parameters after exposure to NO-synthase inhibitor were more pronounced than in the reticular formation nuclei.
authors.affiliation: Department of Human Anatomy, Vladivostok State Medical University, Russia.
authors.forename: V M
authors.initials: VM
authors.lastname: Chertok
authors.forename: A E
authors.initials: AE
authors.lastname: Kotsyuba
mesh_terms: D000367:Age Factors; D000818:Animals; D004791:Enzyme Inhibitors / Q000008:administration & dosage; D007091:Image Processing, Computer-Assisted; D007279:Injections, Subcutaneous; D008853:Microscopy; D009252:NADPH Dehydrogenase / Q000378:metabolism; D019331:NG-Nitroarginine Methyl Ester / Q000008:administration & dosage; D009474:Neurons / Q000187:drug effects / Q000648:ultrastructure*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012154:Reticular Formation / Q000187:drug effects / Q000648:ultrastructure*; D017552:Solitary Nucleus / Q000187:drug effects / Q000648:ultrastructure*; D013237:Stereoisomerism
chemical_list: D004791:Enzyme Inhibitors; D019001:Nitric Oxide Synthase; D009252:NADPH Dehydrogenase; D019331:NG-Nitroarginine Methyl Ester