title: Peptide geroprotector from the pituitary gland inhibits rapid aging of elderly people: results of 15-year follow-up.
abstract: The paper presents the results of randomized comparative study of the efficiency of peptide geroprotector from the pituitary gland in elderly patients with rapidly aging cardiovascular system. Over three years 39 coronary patients received, in addition to basic therapy, regular courses of epithalamin (peptide drug), while 40 coronary patients (control group) received basic therapy alone. Long-term treatment with epithalamin (6 courses over 3 years) decelerated aging of the cardiovascular system, prevented age-associated impairment of physical endurance, normalized circadian rhythm of melatonin production and carbohydrate and lipid metabolism. A significantly lower mortality in the group of patients treated with epithalamin in parallel with basic therapy also indicated a geroprotective effect of the peptide preparation from the pineal gland.
authors.affiliation: Institute of Gerontology, the National Academy of Medical Sciences of Ukraine, Kiev, Ukraine.
authors.forename: O V
authors.initials: OV
authors.lastname: Korkushko
authors.forename: V Kh
authors.initials: VKh
authors.lastname: Khavinson
authors.forename: V B
authors.initials: VB
authors.lastname: Shatilo
authors.forename: I A
authors.initials: IA
authors.lastname: Antonyk-Sheglova
mesh_terms: D000368:Aged; D000375:Aging / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D001786:Blood Glucose; D050260:Carbohydrate Metabolism / Q000187:drug effects; D002318:Cardiovascular Diseases / Q000188:drug therapy; D002319:Cardiovascular System / Q000187:drug effects* / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D002940:Circadian Rhythm / Q000187:drug effects; D015444:Exercise / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D050356:Lipid Metabolism / Q000187:drug effects; D008297:Male; D008550:Melatonin / Q000096:biosynthesis; D008875:Middle Aged; D010455:Peptides / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D010807:Physical Endurance / Q000187:drug effects; D010870:Pineal Gland / Q000378:metabolism*; D010902:Pituitary Gland / Q000378:metabolism*
chemical_list: D001786:Blood Glucose; D010455:Peptides; C027437:epithalamin; D002784:Cholesterol; D008550:Melatonin