title: Prior exercise training alleviates the lung inflammation induced by subsequent exposure to environmental cigarette smoke.
abstract: OBJECTIVE
  Environmental cigarette smoke (CS) contains many compounds that are harmful to the respiratory system and lead to chronic lung inflammation and other lung diseases. Exercise training is known to confer protection against diseases with chronic inflammation by reducing inflammatory response in human or experimental animals. In this study, we investigated the preventive effect of exercise training against lung inflammation induced by environmental CS.
  
  
  RESULTS
  In this study, two groups of mice received air exposure with (the exercise group) or without (the control group) exercise training for 8 weeks and another two groups received air exposure for the first 4 weeks and CS exposure for the following 4 weeks with (the exercise+CS group) or without (the CS group) exercise training for 8 weeks. As compared with lung tissues of control and exercise groups, those of the CS group showed significantly increased bronchoalveolar-capillary permeability, inflammatory cell infiltration, epithelial thickening, expression of proliferating cell nuclear antigen, mucin 2, cytokines, chemokines, adhesion molecules and activation of NF-κB. These CS-induced pathophysiologic consequences were largely prevented in the exercise + CS group.
  
  
  CONCLUSIONS
  Collectively, prior exercise training may protect against lung inflammation induced by environmental CS in mice by attenuating the activation of NF-κB and the production of inflammatory mediators.
authors.affiliation: Department of Physiology, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
authors.forename: Y-B
authors.initials: YB
authors.lastname: Yu
authors.forename: Y-W
authors.initials: YW
authors.lastname: Liao
authors.forename: K-H
authors.initials: KH
authors.lastname: Su
authors.forename: T-M
authors.initials: TM
authors.lastname: Chang
authors.forename: S-K
authors.initials: SK
authors.lastname: Shyue
authors.forename: Y R
authors.initials: YR
authors.lastname: Kou
authors.forename: T-S
authors.initials: TS
authors.lastname: Lee
mesh_terms: D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry / Q000166:cytology; D007249:Inflammation / Q000139:chemically induced; D008171:Lung Diseases / Q000139:chemically induced*; D051379:Mice; D009093:Mucus / Q000378:metabolism; D010805:Physical Conditioning, Animal; D020545:Respiratory Mucosa / Q000187:drug effects / Q000473:pathology; D012907:Smoking; D014028:Tobacco Smoke Pollution / Q000009:adverse effects*
chemical_list: D014028:Tobacco Smoke Pollution