title: Severe central sleep apnea in a child with leukemia on chronic methadone therapy.
abstract: We describe a child with acute myeloid leukemia (AML) who developed severe central sleep apnea (CSA) on methadone therapy for chronic pain management. His chemotherapy-related cerebral atrophy and renal insufficiency with impaired methadone clearance may have also contributed to the severity of his sleep-disordered breathing. Maintenance methadone treatment is not a common pediatric practice; therefore, the adverse effects of methadone therapy, including CSA, are rarely reported in children.
authors.affiliation: Department of Pediatrics, Medical College of Wisconsin, Children’s Hospital of Wisconsin, Milwaukee, WI 53226, USA. lamos@mcw.edu
authors.forename: Louella B
authors.initials: LB
authors.lastname: Amos
authors.forename: Lynn A
authors.initials: LA
authors.lastname: D'Andrea
mesh_terms: D000701:Analgesics, Opioid / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications; D008297:Male; D008691:Methadone / Q000009:adverse effects* / Q000627:therapeutic use; D010146:Pain / Q000209:etiology; D012720:Severity of Illness Index; D020182:Sleep Apnea, Central / Q000139:chemically induced*
chemical_list: D000701:Analgesics, Opioid; D008691:Methadone