title: The potential of stem cell therapy for stroke: is PISCES the sign?
abstract: Substantial developments in the field of stem cell research point toward novel therapies for the treatment of diseases such as stroke. This review covers the establishment of tissue damage in stroke and the status of current therapies. We evaluate stem cell therapy with respect to other treatments, including clinical, preclinical, and failed, and provide a comprehensive account of stem cell clinical trials for stroke therapy currently underway. Finally, we describe mechanisms through which stem cells improve outcome in experimental stroke as well as potential pitfalls this basic research has identified.
authors.affiliation: Wolfson Neuroscience Laboratories, Department of Medicine, Imperial College London, London, UK.
authors.forename: Helen K
authors.initials: HK
authors.lastname: Smith
authors.forename: Felicity N E
authors.initials: FN
authors.lastname: Gavins
mesh_terms: D000818:Animals; D017321:Clinical Trials, Phase I as Topic; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000637:transplantation; D045164:Mesenchymal Stem Cell Transplantation; D055495:Neurogenesis; D015427:Reperfusion Injury / Q000503:physiopathology; D033581:Stem Cell Transplantation / Q000379:methods; D020521:Stroke / Q000473:pathology / Q000628:therapy*; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use
chemical_list: D010959:Tissue Plasminogen Activator