title: Morphofunctional characteristic of the immune system in BALB/c and C57BL/6 mice.
abstract: Inbred animals serve as an adequate model to study the role of genetic factors in adaptive, disadaptive, and pathological processes. Morphofunctional study of the immune system was performed on intact BALB/c and C57Bl/6 mice. The structural and functional parameters of the immune system in BALB/c and C57Bl/6 mice differ under physiological conditions. In BALB/c mice, volume density of T zone in the spleen and production of IL-2, IL-3, IL-4, IL-10, and TNF-α were much higher than in C57Bl/6 mice. However, IL-12 production in BALB/c mice was lower than in C57Bl/6 mice. C57Bl/6 mice were characterized by higher cytostatic activity of splenic NK cells. The observed interstrain differences are genetically determined and contribute to the type of adaptive processes and different sensitivity of these mice to pathogenic agents.
authors.affiliation: Laboratory for Immunomorphology of Inflammation, Institute of Human Morphology, Russian Academy of Medical Sciences, Moscow, Russia. 7ga-lka7@mail.ru
authors.forename: G V
authors.initials: GV
authors.lastname: Trunova
authors.forename: O V
authors.initials: OV
authors.lastname: Makarova
authors.forename: M E
authors.initials: ME
authors.lastname: Diatroptov
authors.forename: I M
authors.initials: IM
authors.lastname: Bogdanova
authors.forename: L P
authors.initials: LP
authors.lastname: Mikchailova
authors.forename: S O
authors.initials: SO
authors.lastname: Abdulaeva
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D002478:Cells, Cultured; D016207:Cytokines / Q000096:biosynthesis / Q000276:immunology*; D003601:Cytotoxicity Tests, Immunologic; D007107:Immune System; D007694:Killer Cells, Natural / Q000166:cytology / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology*; D008810:Mice, Inbred C57BL / Q000276:immunology*; D013045:Species Specificity; D013154:Spleen / Q000166:cytology* / Q000276:immunology; D058408:Th1-Th2 Balance; D013950:Thymus Gland / Q000166:cytology* / Q000276:immunology
chemical_list: D016207:Cytokines