title: The STF2p hydrophilin from Saccharomyces cerevisiae is required for dehydration stress tolerance.
abstract: The yeast Saccharomyces cerevisiae is able to overcome cell dehydration; cell metabolic activity is arrested during this period but restarts after rehydration. The yeast genes encoding hydrophilin proteins were characterised to determine their roles in the dehydration-resistant phenotype, and STF2p was found to be a hydrophilin that is essential for survival after the desiccation-rehydration process. Deletion of STF2 promotes the production of reactive oxygen species and apoptotic cell death during stress conditions, whereas the overexpression of STF2, whose gene product localises to the cytoplasm, results in a reduction in ROS production upon oxidative stress as the result of the antioxidant capacity of the STF2p protein.
authors.affiliation: Department of Biochemistry and Biotechnology, University Rovira i Virgili, Tarragona, Spain.
authors.forename: Gema
authors.initials: G
authors.lastname: López-Martínez
authors.forename: Boris
authors.initials: B
authors.lastname: Rodríguez-Porrata
authors.forename: Mar
authors.initials: M
authors.lastname: Margalef-Català
authors.forename: Ricardo
authors.initials: R
authors.lastname: Cordero-Otero
mesh_terms: D000975:Antioxidants / Q000378:metabolism*; D017209:Apoptosis / Q000235:genetics; D003593:Cytoplasm / Q000235:genetics / Q000378:metabolism*; D003681:Dehydration / Q000235:genetics / Q000378:metabolism*; D017353:Gene Deletion; D017382:Reactive Oxygen Species / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species; C469353:STF2 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins