title: Regioselectivity switch achieved in the palladium catalyzed α-arylation of enones by employing the modified Kuwajima-Urabe conditions.
abstract: A new regioselective approach to the synthesis of α-aryl enones is reported. This represents an important application of the Kuwajima-Urabe protocol toward the synthesis of this simple albeit complex functional array. Several α-aryl enones were synthesized by the palladium catalyzed arylation of triethylsilylenol ethers of enones with high regioselectivity and broad scope, utilizing sterically encumbered electron-rich phosphine ligands to drive the reaction.
authors.affiliation: Department of Chemistry, Indian Institute of Science Education and Research Bhopal, ITI (Gas Rahat) Building, Raisen Road, Bhopal 462023, India.
authors.forename: Ajit Prabhakar
authors.initials: AP
authors.lastname: Kale
authors.forename: Govind Goroba
authors.initials: GG
authors.lastname: Pawar
authors.forename: Manmohan
authors.initials: M
authors.lastname: Kapur