title: Convulsive seizure detection using a wrist-worn electrodermal activity and accelerometry biosensor.
abstract: The special requirements for a seizure detector suitable for everyday use in terms of cost, comfort, and social acceptance call for alternatives to electroencephalography (EEG)-based methods. Therefore, we developed an algorithm for automatic detection of generalized tonic-clonic (GTC) seizures based on sympathetically mediated electrodermal activity (EDA) and accelerometry measured using a novel wrist-worn biosensor. The problem of GTC seizure detection was posed as a supervised learning task in which the goal was to classify 10-s epochs as a seizure or nonseizure event based on 19 extracted features from EDA and accelerometry recordings using a Support Vector Machine. Performance was evaluated using a double cross-validation method. The new seizure detection algorithm was tested on >4,213 h of recordings from 80 patients and detected 15 (94%) of 16 of the GTC seizures from seven patients with 130 false alarms (0.74 per 24 h). This algorithm can potentially provide a convulsive seizure alarm system for caregivers and objective quantification of seizure frequency.
authors.affiliation: Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 75 Amherst St., Cambridge, MA 02139, U.S.A. zher@mit.edu
authors.forename: Ming-Zher
authors.initials: MZ
authors.lastname: Poh
authors.forename: Tobias
authors.initials: T
authors.lastname: Loddenkemper
authors.forename: Claus
authors.initials: C
authors.lastname: Reinsberger
authors.forename: Nicholas C
authors.initials: NC
authors.lastname: Swenson
authors.forename: Shubhi
authors.initials: S
authors.lastname: Goyal
authors.forename: Mangwe C
authors.initials: MC
authors.lastname: Sabtala
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Madsen
authors.forename: Rosalind W
authors.initials: RW
authors.lastname: Picard
mesh_terms: D000293:Adolescent; D015374:Biosensing Techniques / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography / Q000379:methods; D005260:Female; D005712:Galvanic Skin Response / Q000502:physiology*; D006801:Humans; D007702:Kinetocardiography / Q000379:methods*; D008297:Male; D012640:Seizures / Q000175:diagnosis*; D013997:Time Factors; D014953:Wrist / Q000294:innervation*