title: Functional MRI finding by proprioceptive input in patients with thalamic hemorrhage.
abstract: Little is known about the recovery mechanism of somatosensory function in thalamic hemorrhage. We investigated the recovery mechanism of somatosensory function, using functional MRI (fMRI) findings by proprioceptive input in chronic patients with thalamic hemorrhage. Eleven consecutive chronic patients with thalamic hemorrhage who showed severe proprioceptive dysfunction were recruited. The subscale for kinesthetic sensation of the Nottingham Sensory Assessment (NSA) was used for determination of proprioceptive function. fMRI was performed during passive movements of the metacarpophalangeal joint. From fMRI, the laterality index (LI) was calculated for assessment of the relative activity in the ipsilateral versus the contralateral primary sensori-motor cortex (SM1). The average LI for affected and unaffected hand stimulation was 0.89 and 0.90, respectively, and there was no significant difference between LIs (p> 0.05). In addition, LI of the affected hand stimulation was positively related to NSA scores (r=0.790, p< 0.05). Our results for LI suggest that the cortical activation pattern of SM1 was similar in the affected and unaffected hemispheres. Therefore, it appears that the proprioceptive function of the affected hand likely recovered by the normally existing medial lemniscus and its thalamocortical pathway in our patients.
authors.affiliation: Department of Physical Therapy, College of Health and Therapy, Daegu Haany University, Daegu, Republic of Korea.
authors.forename: Mi Young
authors.initials: MY
authors.lastname: Lee
authors.forename: Seong Ho
authors.initials: SH
authors.lastname: Kim
authors.forename: Byung Yun
authors.initials: BY
authors.lastname: Choi
authors.forename: Cheol Hoon
authors.initials: CH
authors.lastname: Chang
authors.forename: Sang Ho
authors.initials: SH
authors.lastname: Ahn
authors.forename: Sung Ho
authors.initials: SH
authors.lastname: Jang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001931:Brain Mapping; D005260:Female; D007839:Functional Laterality; D006470:Hemorrhage / Q000209:etiology / Q000473:pathology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D011434:Proprioception / Q000502:physiology*; D020127:Recovery of Function / Q000502:physiology*; D020521:Stroke / Q000150:complications; D013788:Thalamus / Q000098:blood supply* / Q000503:physiopathology
chemical_list: D010100:Oxygen