title: [The role of congenital immunity components in the protection of the intranasal mucous membrane under normal conditions and in the case of hypertrophy of adenoid vegetation].
abstract: The objective of the present work was to evaluate expression of the genes recognizing receptors of congenital immunity (Toll-like receptors) and human antimicrobial peptide HBD-2 in the cells of nasal cavity mucosa of the children aged from 2 to 8 years and suffering hypertrophy of adenoid vegetations. A total of 49 patients at the age from 2 to 8 years were included in the study. The control group was comprised of 12 age-matched healthy children. The level of gene expression in epithelial cells was measured in the samples obtained from nasal cavity mucosa using the real-time polymerase chain reaction technique. It is concluded that the proposed approach makes it possible to estimate the state of the congenital immunity system at the level of nasal cavity mucosa in the patients with a variety of ENT organ diseases and to choose the most adequate strategy for their treatment.
mesh_terms: D000234:Adenoids / Q000276:immunology* / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D005786:Gene Expression Regulation / Q000276:immunology; D006801:Humans; D006984:Hypertrophy; D009297:Nasal Mucosa / Q000276:immunology / Q000473:pathology*; D012720:Severity of Illness Index; D051193:Toll-Like Receptors / Q000235:genetics; D023083:beta-Defensins / Q000235:genetics
chemical_list: D051193:Toll-Like Receptors; D023083:beta-Defensins