title: Antidiabetic and antioxidant effect of Semecarpus anacardium Linn. nut milk extract in a high-fat diet STZ-induced type 2 diabetic rat model.
abstract: Semecarpus anacardium commonly known as marking nut has been used in the Siddha system of medicine against various ailments. The antidiabetic and antioxidant potential of the drug was evaluated in Type 2 diabetic rats induced by feeding a high-fat diet (HFD) for 2 weeks followed by single intraperitoneal injection of streptozotocin (STZ) 35 mg/kg body weight. Three days after STZ induction, the hyperglycemic rats were treated with Semecarpus anacardium nut milk extract (SA) orally at a dosage of 200 mg/kg body weight daily for 30 days. Metformin (500 mg/kg body weight, orally) was used as a reference drug. The fasting blood glucose, insulin, Hb, HbA1c levels, and HOMA-IR and HOMA-β were measured, and also the levels of lipid peroxidation and antioxidant enzymes were observed. SA significantly (p < .05) reduced and normalized blood glucose levels and also decreased the levels of HbA1c as compared with that of HFD STZ control group. SA treatment also significantly (p < .05) increased the levels of antioxidant enzymes while decreasing the levels of lipid peroxidation. The potential antihyperglycemic action and antioxidant role might be due to the presence of flavonoids in the drug.
authors.affiliation: Department of Medical Biochemistry, University of Madras,   Chennai, Tamil Nadu,   India.
authors.forename: Haseena Banu Hedayathullah
authors.initials: HB
authors.lastname: Khan
authors.forename: Kaladevi Siddhi
authors.initials: KS
authors.lastname: Vinayagam
authors.forename: Ashwini
authors.initials: A
authors.lastname: Sekar
authors.forename: Shanthi
authors.initials: S
authors.lastname: Palanivelu
authors.forename: Sachdanandam
authors.initials: S
authors.lastname: Panchanadham
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D001786:Blood Glucose / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D004032:Diet; D004041:Dietary Fats / Q000009:adverse effects; D005419:Flavonoids / Q000494:pharmacology / Q000627:therapeutic use; D006442:Glycated Hemoglobin / Q000378:metabolism*; D007004:Hypoglycemic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008687:Metformin / Q000494:pharmacology / Q000627:therapeutic use; D009754:Nuts; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D031023:Semecarpus / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D004041:Dietary Fats; D005419:Flavonoids; D006442:Glycated Hemoglobin; D007004:Hypoglycemic Agents; D008687:Metformin; D010936:Plant Extracts