title: Comparison of oral robenacoxib and ketoprofen for the treatment of acute pain and inflammation associated with musculoskeletal disorders in cats: a randomised clinical trial.
abstract: The objective of the study was to evaluate the efficacy and tolerability of robenacoxib, a selective cyclooxygenase-2 inhibitor, for the treatment of acute pain and inflammation associated with musculoskeletal disorders in cats. The study was a prospective, multi-centre, randomised, blinded, non-inferiority design clinical trial comparing robenacoxib to ketoprofen. A total of 68 cats presenting with pain and inflammation associated with acute musculoskeletal disorders were recruited and allocated randomly to receive, orally once daily for 5-6 days, either 1.0-2.4 mg/kg robenacoxib (n=47) or 1mg/kg ketoprofen (n=21). The primary efficacy endpoint was the total clinician score, which was the sum of clinician numerical rating scale scores for pain, inflammation and mobility. Assessments were made at baseline, on day 2, and day 4 or 5. For the total clinician score, non-inferior efficacy of robenacoxib was demonstrated with a relative efficacy of 1.151 (95% confidence interval 0.872-1.494). Non-inferior efficacy of robenacoxib was also demonstrated for the secondary endpoint of the total owner score. Robenacoxib was superior (P<0.05) to ketoprofen for the owner's assessment of activity and human/animal relationship. The tolerability of both treatments was good as assessed by monitoring adverse events, clinical signs and haematology and serum biochemistry variables.
authors.affiliation: Laboratory of Comprehensive Veterinary Clinical Studies, College of Bioresource Sciences, NIHON University, Kanagawa 252-0880, Japan. tsano@brs.nihon-u.ac.jp
authors.forename: Tadashi
authors.initials: T
authors.lastname: Sano
authors.forename: Jonathan N
authors.initials: JN
authors.lastname: King
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Seewald
authors.forename: Nobuhiro
authors.initials: N
authors.lastname: Sakakibara
authors.forename: Masahiro
authors.initials: M
authors.lastname: Okumura
mesh_terms: D059787:Acute Pain / Q000188:drug therapy / Q000662:veterinary*; D000284:Administration, Oral; D000818:Animals; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D052246:Cyclooxygenase 2 Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D004159:Diphenylamine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D007249:Inflammation / Q000188:drug therapy / Q000662:veterinary*; D007660:Ketoprofen / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D009140:Musculoskeletal Diseases / Q000188:drug therapy / Q000662:veterinary; D010648:Phenylacetates / Q000009:adverse effects / Q000627:therapeutic use*; D011446:Prospective Studies; D016037:Single-Blind Method; D013607:Tablets
chemical_list: D052246:Cyclooxygenase 2 Inhibitors; D010648:Phenylacetates; D013607:Tablets; D007660:Ketoprofen; D004159:Diphenylamine; C551524:robenacoxib