title: Necrobiotic xanthogranuloma of the extremities with paraproteinemia and without periorbital involvement at presentation.
abstract: We report a rare case of necrobiotic xanthogranuloma (NXG) of the extremities with paraproteinemia and without periorbital involvement at presentation in a 58-year-old white woman. A combination of oral cyclophosphamide and oral dexamethasone was attempted, but the patient then developed a left intraorbital lesion. Treatment was not successful in that the gammopathy did not improve and the patient continued to develop more lesions.
authors.affiliation: Ackerman Academy of Dermatopathology, New York, New York, USA.
authors.forename: Pantea
authors.initials: P
authors.lastname: Hashemi
authors.forename: Armin
authors.initials: A
authors.lastname: Rashidi
authors.forename: Anne M
authors.initials: AM
authors.lastname: Chapas
authors.forename: Erika M
authors.initials: EM
authors.lastname: Balfour
mesh_terms: D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D001132:Arm / Q000473:pathology*; D003520:Cyclophosphamide / Q000627:therapeutic use; D003907:Dexamethasone / Q000627:therapeutic use; D018450:Disease Progression; D005128:Eye Diseases / Q000209:etiology; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D058252:Necrobiotic Xanthogranuloma / Q000150:complications* / Q000473:pathology*; D010265:Paraproteinemias / Q000150:complications* / Q000188:drug therapy; D013848:Thigh / Q000473:pathology*
chemical_list: D018906:Antineoplastic Agents, Alkylating; D005938:Glucocorticoids; D003907:Dexamethasone; D003520:Cyclophosphamide