title: Cerebrospinal fluid cathepsin B and S.
abstract: Cathepsins are increased in the brain of elderly animals. We investigate the presence of cathepsin B and S in human cerebrospinal fluid (CSF) plasma and the associations with cystatin C, age and sex. We measured cathepsin B and S concentrations in CSFs from 118 persons, undergoing elective surgical procedures, with ELISA. Both cathepsin B and cathepsin S were positively correlated with age. No correlation was observed between cathepsin B or S and length, height or body mass index. Both cathepsin B and S were positively correlated to the cystatin C concentration in CSF. Calculated reference intervals were 4,893-17,636 pg/mL for cathepsin B and 2,681-11,459 pg/mL for cathepsin S. Elderly individuals had significantly higher levels of both cathepsin B (r s = 0.38, p = 0.00002) and cathepsin S (r s = 0.35, p = 0.0001) in CSF.
authors.affiliation: Department of Medical Sciences, Clinical Chemistry, Uppsala University Hospital, 751 85 Uppsala, Sweden.
authors.forename: Elin
authors.initials: E
authors.lastname: Nilsson
authors.forename: Constantin
authors.initials: C
authors.lastname: Bodolea
authors.forename: Torsten
authors.initials: T
authors.lastname: Gordh
authors.forename: Anders
authors.initials: A
authors.lastname: Larsson
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002401:Cathepsin B / Q000134:cerebrospinal fluid*; D002403:Cathepsins / Q000134:cerebrospinal fluid*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid*; D013129:Spinal Puncture; D055815:Young Adult
chemical_list: D002403:Cathepsins; D002401:Cathepsin B; C028217:cathepsin S