title: Epidemiology of Escherichia coli, Klebsiella species, and Proteus mirabilis strains producing extended-spectrum β-lactamases from clinical samples in the Kinki Region of Japan.
abstract: In the present study, nonduplicate, clinical isolates of extended-spectrum β-lactamase (ESBL)-producing Escherichia coli, Klebsiella spp, and Proteus mirabilis were collected during a 10-year period from 2000 to 2009 at several hospitals in the Kinki region, Japan. The detection rate of E coli markedly increased from 0.24% to 7.25%. The detection rate of Klebsiella pneumoniae increased from 0% to 2.44% and that of P mirabilis from 6.97% to 12.85%. The most frequently detected genotypes were the CTX-M9 group for E coli, the CTX-M2 group for K pneumoniae, and the CTX-M2 group for P mirabilis. E coli clone O25:H4-ST131 producing CTX-M-15, which is spreading worldwide, was first detected in 2007. The most common replicon type of E coli was the IncF type, particularly FIB, detected in 466 strains (69.7%). Of the K pneumoniae strains, 47 (55.3%) were of the IncN type; 77 P mirabilis strains (96.3%) were of the IncT type. In the future, the surveillance of various resistant bacteria, mainly ESBL-producing Enterobacteriaceae, should be expanded to prevent their spread.
authors.affiliation: Department of Clinical Laboratory, Kansai Medical University Hirakata Hospital, Osaka, Japan.
authors.forename: Tatsuya
authors.initials: T
authors.lastname: Nakamura
authors.forename: Masaru
authors.initials: M
authors.lastname: Komatsu
authors.forename: Katsutoshi
authors.initials: K
authors.lastname: Yamasaki
authors.forename: Saori
authors.initials: S
authors.lastname: Fukuda
authors.forename: Yugo
authors.initials: Y
authors.lastname: Miyamoto
authors.forename: Takeshi
authors.initials: T
authors.lastname: Higuchi
authors.forename: Tamotsu
authors.initials: T
authors.lastname: Ono
authors.forename: Hisaaki
authors.initials: H
authors.lastname: Nishio
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Sueyoshi
authors.forename: Kenji
authors.initials: K
authors.lastname: Kida
authors.forename: Kaori
authors.initials: K
authors.lastname: Satoh
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Toda
authors.forename: Masahiro
authors.initials: M
authors.lastname: Toyokawa
authors.forename: Isao
authors.initials: I
authors.lastname: Nishi
authors.forename: Masako
authors.initials: M
authors.lastname: Sakamoto
authors.forename: Masahiro
authors.initials: M
authors.lastname: Akagi
authors.forename: Isako
authors.initials: I
authors.lastname: Nakai
authors.forename: Tomomi
authors.initials: T
authors.lastname: Kofuku
authors.forename: Tamaki
authors.initials: T
authors.lastname: Orita
authors.forename: Yasunao
authors.initials: Y
authors.lastname: Wada
authors.forename: Takuya
authors.initials: T
authors.lastname: Zikimoto
authors.forename: Chihiro
authors.initials: C
authors.lastname: Koike
authors.forename: Shohiro
authors.initials: S
authors.lastname: Kinoshita
authors.forename: Itaru
authors.initials: I
authors.lastname: Hirai
authors.forename: Hakuo
authors.initials: H
authors.lastname: Takahashi
authors.forename: Nariaki
authors.initials: N
authors.lastname: Matsuura
authors.forename: Yoshimasa
authors.initials: Y
authors.lastname: Yamamoto
mesh_terms: D015373:Bacterial Typing Techniques; D004269:DNA, Bacterial / Q000235:genetics; D004926:Escherichia coli / Q000235:genetics* / Q000302:isolation & purification; D004927:Escherichia coli Infections / Q000453:epidemiology* / Q000235:genetics / Q000382:microbiology; D006801:Humans; D007564:Japan / Q000453:epidemiology; D007709:Klebsiella / Q000235:genetics* / Q000302:isolation & purification; D007710:Klebsiella Infections / Q000453:epidemiology* / Q000235:genetics / Q000382:microbiology; D017720:Molecular Epidemiology; D011512:Proteus Infections / Q000453:epidemiology* / Q000235:genetics / Q000382:microbiology; D011513:Proteus mirabilis / Q000235:genetics* / Q000302:isolation & purification; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D004269:DNA, Bacterial; D001618:beta-Lactamases