title: Veratric acid ameliorates hyperlipidemia and oxidative stress in Wistar rats fed an atherogenic diet.
abstract: An investigation was made to reveal the protective effects of veratric acid (VA), a phenolic acid against atherogenic diet-induced hyperlipidemic rats. Male albino Wistar rats were fed with atherogenic diet (4% cholesterol, 1% cholic acid, and 0.5% 2-thiouracil) daily for 30 days and treated with VA (40 mg/kg body weight) daily for a period of 30 days. Rats fed with atherogenic diet showed significant (P < 0.05) elevation in the level of plasma lipids, systolic and diastolic blood pressure, oxidative stress markers (thiobarbituric acid reactive substances, lipid peroxides) and significant (P < 0.05) reduction in the activities of enzymatic (superoxide dismutase, catalase, glutathione peroxidase) and non-enzymatic (vitamin C, vitamin E, and reduced glutathione) antioxidants in erythrocytes, plasma, and tissues (liver, kidney, and aorta). Oral administration of VA (40 mg/kg body weight) for 30 days to atherogenic diet fed rats markedly attenuates systolic, diastolic blood pressure and lipid peroxidation products. Further, VA treatment significantly improved enzymatic and non-enzymatic antioxidants levels and showed beneficial effects on lipid profile in atherogenic diet rats. All the above alterations were supported by histopathological observations. These results indicate that oral administration of VA ameliorates atherogenic diet-induced hyperlipidemia in rats by its free radical scavenging; improving the antioxidants and lipid lowering properties.
authors.affiliation: Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai Nagar, 608 002 Tamil Nadu, India. drrajaau@gmail.com
authors.forename: Boobalan
authors.initials: B
authors.lastname: Raja
authors.forename: Murugesan
authors.initials: M
authors.lastname: Saravanakumar
authors.forename: Gopal
authors.initials: G
authors.lastname: Sathya
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001013:Aorta, Thoracic / Q000201:enzymology / Q000378:metabolism; D001205:Ascorbic Acid / Q000097:blood / Q000378:metabolism; D001794:Blood Pressure; D001835:Body Weight; D002374:Catalase / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D004036:Diet, Atherogenic; D004734:Energy Metabolism; D004912:Erythrocytes / Q000201:enzymology; D005978:Glutathione / Q000097:blood / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D006937:Hypercholesterolemia / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D007668:Kidney / Q000201:enzymology / Q000378:metabolism; D015227:Lipid Peroxidation; D008055:Lipids / Q000097:blood; D008099:Liver / Q000201:enzymology / Q000378:metabolism / Q000473:pathology; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014641:Vanillic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D014810:Vitamin E / Q000097:blood / Q000378:metabolism
chemical_list: D000924:Anticholesteremic Agents; D008055:Lipids; D017392:Thiobarbituric Acid Reactive Substances; D014810:Vitamin E; C009333:veratric acid; D002784:Cholesterol; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione; D014641:Vanillic Acid; D001205:Ascorbic Acid