title: Antioxidant and antiangiogenic activities of the essential oils of Myristica fragrans and Morinda citrifolia.
abstract: OBJECTIVE
  Toinvestigate the anti-angiogenic activity and antioxidant properties of Myristica fragrans (M. fragrans) (nutmeg) and Morinda citrifolia (M. citrifolia)(mengkudu) oils.
  
  
  METHODS
  The nutmeg and megkudu essential oils were obtained by steam distillation. The antioxidant activities of both essential oils were determined by beta-carotene/linoleic acid bleaching assay and reducing power while the anti-angiogenic activity was investigated using rat aortic ring assay using various concentrations.
  
  
  RESULTS
  The results showed that nutmeg oil has higher antioxidant activity than mengkudu oil. The nutmeg oil effectively inhibited the oxidation of linoleic acid with (88.68±0.1)% while the inhibition percentage of oxidation of linoleic acid of the mengkudu oil is (69.44±0.4)%. The nutmeg oil and mengkudu oil showed reducing power with an EC(50) value of 181.4 μg/mL and 3 043.0 μg/mL, respectively. The antiangiogenic activity of nutmeg oil showed significant antiangiogenic activity with IC(50) of 77.64 μg/mL comparing to mengkudu oil which exhibits IC(50) of 109.30 μg/mL.
  
  
  CONCLUSIONS
  Bioactive compound(s) will be isolated from the nutmeg essential oil to be developed as antiangiogenic drugs.
authors.affiliation: School of Pharmaceutical Sciences, Universiti Sains Malaysia, 11800 Penang, Malaysia. suthagar_pillai@yahoo.com
authors.forename: Suthagar Pillai
authors.initials: SP
authors.lastname: Piaru
authors.forename: Roziahanim
authors.initials: R
authors.lastname: Mahmud
authors.forename: Amin Malik Shah
authors.initials: AM
authors.lastname: Abdul Majid
authors.forename: Zeyad Daoud
authors.initials: ZD
authors.lastname: Mahmoud Nassar
mesh_terms: D000704:Analysis of Variance; D020533:Angiogenesis Inhibitors / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001011:Aorta / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D032066:Morinda; D026323:Myristica; D009822:Oils, Volatile / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012639:Seeds
chemical_list: D020533:Angiogenesis Inhibitors; D000975:Antioxidants; D009822:Oils, Volatile