title: Effect of fat pad ablation on the spatial and temporal stability of complex fractionated atrial electrogram in acetylcholine-induced atrial fibrillation.
abstract: OBJECTIVE
  The objective of this study was to investigate the effect of selective fat pad ablation on the spatial and temporal stability of the complex fractionated atrial electrogram (CFAE) in acetylcholine (ACh)-induced atrial fibrillation (AF).
  
  
  RESULTS
  ACh was applied to fat pads in 10 dogs. Effective refractory periods (ERPs) at 5 different sites, AF inducibility and AF duration were obtained before and after fat pad ablation. During the first two induced AFs, the number of sites with continuous CFAEs and the duration of continuous CFAEs at every site were measured before and after fat pad ablation. The average ERP was shortened by ACh application (138 14 vs 100 15 ms, P < 0.001) and increased after fat pad ablation (100 +/- 15 vs. 115 +/- 14 ms, P < 0.001). AF inducibility (76 +/- 9% vs. 4 +/- 6%, P < 0.001) and AF duration (56 +/- 11 vs. 187 +/- 56 s, P = 0.01) increased after ACh application compared to baseline; while fat pad ablation reduced AF inducibility (76% +/- 9% vs. 54% +/- 6%, P < 0.001) and AF duration (187 +/- 56 vs. 144% +/- 35 s, P = 0.015). The percentage of sites with continuous CFAE decreased after fat pad ablation compared with that before fat pad ablation (24% vs. 82%, P < 0.001). On average, fat pad ablation reduced the duration of continuous CFAEs (188 +/- 63 vs. 139 +/- 31 s, P < 0.001).
  
  
  CONCLUSIONS
  Selective fat pad ablation can affect the spatial and temporal stability of CFAEs in ACh-induced atrial fibrillation in dogs.
authors.affiliation: Center for Arrhythmia Diagnosis and Treatment, Fu Wai Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China.
authors.forename: Sen
authors.initials: S
authors.lastname: Lei
authors.forename: Pi-hua
authors.initials: PH
authors.lastname: Fang
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.forename: Yu
authors.initials: Y
authors.lastname: Hou
mesh_terms: D055011:Ablation Techniques; D000109:Acetylcholine / Q000008:administration & dosage; D000273:Adipose Tissue / Q000503:physiopathology* / Q000601:surgery*; D000818:Animals; D001281:Atrial Fibrillation / Q000139:chemically induced / Q000503:physiopathology*; D004285:Dogs; D022062:Electrophysiologic Techniques, Cardiac; D005260:Female; D008297:Male
chemical_list: D000109:Acetylcholine