title: Cascade intermolecular Michael addition-intramolecular azide/internal alkyne 1,3-dipolar cycloaddition reaction in one pot.
abstract: A rapid one-pot protocol for the synthesis of indole-based polyheterocycles via a sequential Lewis acid catalyzed intermolecular Michael addition and an intramolecular azide/internal alkyne 1,3-dipolar cycloaddition reaction has been described. The generality of the method has been demonstrated by treating a series of aromatic/aliphatic 2-alkynyl indoles with substituted (E)-1-azido-2-(2-nitrovinyl)benzenes to furnish annulated tetracyclic indolo[2,3-c][1,2,3]triazolo[1,5-a][1]benzazepines in good yields.
authors.affiliation: Medicinal & Process Chemistry Division, Central Drug Research Institute, CSIR, Lucknow-226001, India.
authors.forename: Rajesh K
authors.initials: RK
authors.lastname: Arigela
authors.forename: Anil K
authors.initials: AK
authors.lastname: Mandadapu
authors.forename: Sudhir K
authors.initials: SK
authors.lastname: Sharma
authors.forename: Brijesh
authors.initials: B
authors.lastname: Kumar
authors.forename: Bijoy
authors.initials: B
authors.lastname: Kundu
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D006576:Heterocyclic Compounds, 4 or More Rings / Q000138:chemical synthesis* / Q000737:chemistry; D058116:Lewis Acids / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D000480:Alkynes; D006576:Heterocyclic Compounds, 4 or More Rings; D058116:Lewis Acids