title: Cobalt, nickel, copper and zinc complexes with 1,3-diphenyl-1H-pyrazole-4-carboxaldehyde Schiff bases: antimicrobial, spectroscopic, thermal and fluorescence studies.
abstract: Two new Schiff bases of 1,3-diphenyl-1H-pyrazole-4-carboxaldehyde and 4-amino-5-mercapto-3-methyl/H-1,2,4-triazole [HL(1-2)] and their Cobalt, Nickel, Copper and Zinc complexes have been synthesized and characterized by elemental analyses, spectral (UV-vis, IR, (1)H NMR, Fluorescence) studies, thermal techniques and magnetic measurements. A square planar geometry for Cu(II) and octahedral geometry for Co(II), Ni(II) and Zn(II) complexes have been proposed. In order to evaluate the biological activity of Schiff bases and to assess the role of metal ion on biological activity, the pyrazole Schiff bases and their metal complexes have been studied in vitro antibacterial against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa and antifungal against Aspergillus niger, and Aspergillus flavus. In most of the cases higher activity was exhibited upon coordination with metal ions.
authors.affiliation: Department of Chemistry, Kurukshetra University, Kurukshetra, Haryana 136 119, India. kiransinghkuk@yahoo.co.in
authors.forename: Kiran
authors.initials: K
authors.lastname: Singh
authors.forename: Yogender
authors.initials: Y
authors.lastname: Kumar
authors.forename: Parvesh
authors.initials: P
authors.lastname: Puri
authors.forename: Mahender
authors.initials: M
authors.lastname: Kumar
authors.forename: Chetan
authors.initials: C
authors.lastname: Sharma
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D003035:Cobalt / Q000737:chemistry; D003300:Copper / Q000737:chemistry; D005658:Fungi / Q000187:drug effects; D060328:Magnetic Phenomena; D009532:Nickel / Q000737:chemistry; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D011720:Pyrazoles / Q000737:chemistry*; D012545:Schiff Bases / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D013696:Temperature; D015032:Zinc / Q000737:chemistry
chemical_list: D000890:Anti-Infective Agents; D009942:Organometallic Compounds; D011720:Pyrazoles; D012545:Schiff Bases; D003035:Cobalt; D003300:Copper; D009532:Nickel; D015032:Zinc