title: Neighborhood deprivation and clinical outcomes among head and neck cancer patients.
abstract: The unique effects of neighborhood-level economic deprivation on survival, recurrence, and second primary malignancy development were examined using adjusted Cox proportional hazards regression models among 1151 incident squamous cell carcinomas of the head and neck patients. Cancer site was examined as a potential moderator. Main analyses yielded null results; however, interaction analyses indicated poorer overall survival [HR=1.59 (1.00-2.53)] and greater second primary malignancy development [HR=2.99 (1.46-6.11)] among oropharyngeal cancer patients from highly deprived neighborhoods relative to less deprived neighborhoods. Results suggest a dual focus on individual and neighborhood risk factors could help improve clinical outcomes among oropharyngeal cancer patients.
authors.affiliation: Department of Health Disparities Research-Unit 1440, PO Box 301402, University of Texas MD Anderson Cancer Center, Houston, Texas 77230-1402, USA. Lrreitze@mdanderson.org
authors.forename: Lorraine R
authors.initials: LR
authors.lastname: Reitzel
authors.forename: Nga
authors.initials: N
authors.lastname: Nguyen
authors.forename: Mark E
authors.initials: ME
authors.lastname: Zafereo
authors.forename: Guojun
authors.initials: G
authors.lastname: Li
authors.forename: Qingyi
authors.initials: Q
authors.lastname: Wei
authors.forename: Erich M
authors.initials: EM
authors.lastname: Sturgis
mesh_terms: D000368:Aged; D016021:Epidemiologic Studies; D005260:Female; D006258:Head and Neck Neoplasms / Q000401:mortality* / Q000473:pathology; D054624:Health Status Disparities; D006801:Humans; D008297:Male; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000401:mortality* / Q000473:pathology; D017063:Outcome Assessment, Health Care; D011203:Poverty; D016016:Proportional Hazards Models; D012111:Residence Characteristics; D012189:Retrospective Studies; D012307:Risk Factors; D012923:Social Class; D016019:Survival Analysis