title: A genome-wide association study identifies three new risk loci for Kawasaki disease.
abstract: We performed a genome-wide association study (GWAS) of Kawasaki disease in Japanese subjects using data from 428 individuals with Kawasaki disease (cases) and 3,379 controls genotyped at 473,803 SNPs. We validated the association results in two independent replication panels totaling 754 cases and 947 controls. We observed significant associations in the FAM167A-BLK region at 8p22-23 (rs2254546, P = 8.2 × 10(-21)), in the human leukocyte antigen (HLA) region at 6p21.3 (rs2857151, P = 4.6 × 10(-11)) and in the CD40 region at 20q13 (rs4813003, P = 4.8 × 10(-8)). We also replicated the association of a functional SNP of FCGR2A (rs1801274, P = 1.6 × 10(-6)) identified in a recently reported GWAS of Kawasaki disease. Our findings provide new insights into the pathogenesis and pathophysiology of Kawasaki disease.
authors.affiliation: Laboratory for Cardiovascular Diseases, Center for Genomic Medicine, RIKEN, Yokohama, Japan. onouchi@src.riken.jp
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Onouchi
authors.forename: Kouichi
authors.initials: K
authors.lastname: Ozaki
authors.forename: Jane C
authors.initials: JC
authors.lastname: Burns
authors.forename: Chisato
authors.initials: C
authors.lastname: Shimizu
authors.forename: Masaru
authors.initials: M
authors.lastname: Terai
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Hamada
authors.forename: Takafumi
authors.initials: T
authors.lastname: Honda
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Suzuki
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Suenaga
authors.forename: Takashi
authors.initials: T
authors.lastname: Takeuchi
authors.forename: Norishige
authors.initials: N
authors.lastname: Yoshikawa
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Kumi
authors.initials: K
authors.lastname: Yasukawa
authors.forename: Ryota
authors.initials: R
authors.lastname: Ebata
authors.forename: Kouji
authors.initials: K
authors.lastname: Higashi
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Saji
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Kemmotsu
authors.forename: Shinichi
authors.initials: S
authors.lastname: Takatsuki
authors.forename: Kazunobu
authors.initials: K
authors.lastname: Ouchi
authors.forename: Fumio
authors.initials: F
authors.lastname: Kishi
authors.forename: Tetsushi
authors.initials: T
authors.lastname: Yoshikawa
authors.forename: Toshiro
authors.initials: T
authors.lastname: Nagai
authors.forename: Kunihiro
authors.initials: K
authors.lastname: Hamamoto
authors.forename: Yoshitake
authors.initials: Y
authors.lastname: Sato
authors.forename: Akihito
authors.initials: A
authors.lastname: Honda
authors.forename: Hironobu
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Junichi
authors.initials: J
authors.lastname: Sato
authors.forename: Shoichi
authors.initials: S
authors.lastname: Shibuta
authors.forename: Masakazu
authors.initials: M
authors.lastname: Miyawaki
authors.forename: Ko
authors.initials: K
authors.lastname: Oishi
authors.forename: Hironobu
authors.initials: H
authors.lastname: Yamaga
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Aoyagi
authors.forename: Seiji
authors.initials: S
authors.lastname: Iwahashi
authors.forename: Ritsuko
authors.initials: R
authors.lastname: Miyashita
authors.forename: Yuji
authors.initials: Y
authors.lastname: Murata
authors.forename: Kumiko
authors.initials: K
authors.lastname: Sasago
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takahashi
authors.forename: Naoyuki
authors.initials: N
authors.lastname: Kamatani
authors.forename: Michiaki
authors.initials: M
authors.lastname: Kubo
authors.forename: Tatsuhiko
authors.initials: T
authors.lastname: Tsunoda
authors.forename: Akira
authors.initials: A
authors.lastname: Hata
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Tanaka
mesh_terms: D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D056426:Genetic Loci; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D009080:Mucocutaneous Lymph Node Syndrome / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017452:Receptors, IgG / Q000235:genetics
chemical_list: C445323:FCGR2A protein, human; D005819:Genetic Markers; D017452:Receptors, IgG