title: Tanycytes of the hypothalamic median eminence form a diet-responsive neurogenic niche.
abstract: Adult hypothalamic neurogenesis has recently been reported, but the cell of origin and the function of these newborn neurons are unknown. Using genetic fate mapping, we found that median eminence tanycytes generate newborn neurons. Blocking this neurogenesis altered the weight and metabolic activity of adult mice. These findings reveal a previously unreported neurogenic niche in the mammalian hypothalamus with important implications for metabolism.
authors.affiliation: Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Lee
authors.forename: Joseph L
authors.initials: JL
authors.lastname: Bedont
authors.forename: Thomas
authors.initials: T
authors.lastname: Pak
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
authors.forename: Juan
authors.initials: J
authors.lastname: Song
authors.forename: Ana
authors.initials: A
authors.lastname: Miranda-Angulo
authors.forename: Vani
authors.initials: V
authors.lastname: Takiar
authors.forename: Vanessa
authors.initials: V
authors.lastname: Charubhumi
authors.forename: Francesca
authors.initials: F
authors.lastname: Balordi
authors.forename: Hirohide
authors.initials: H
authors.lastname: Takebayashi
authors.forename: Susan
authors.initials: S
authors.lastname: Aja
authors.forename: Eric
authors.initials: E
authors.lastname: Ford
authors.forename: Gordon
authors.initials: G
authors.lastname: Fishell
authors.forename: Seth
authors.initials: S
authors.lastname: Blackshaw
mesh_terms: D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001426:Bacterial Proteins / Q000235:genetics; D001835:Body Weight / Q000502:physiology; D001973:Bromodeoxyuridine / Q000378:metabolism; D002452:Cell Count; D049109:Cell Proliferation; D059305:Diet, High-Fat; D051959:ELAV Proteins / Q000378:metabolism; D005260:Female; D018507:Gene Expression Regulation, Developmental / Q000187:drug effects / Q000502:physiology*; D006657:Histones / Q000378:metabolism; D007381:Intermediate Filament Proteins / Q000378:metabolism; D008164:Luminescent Proteins / Q000235:genetics; D009682:Magnetic Resonance Spectroscopy; D008473:Median Eminence / Q000166:cytology* / Q000254:growth & development; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009419:Nerve Tissue Proteins / Q000378:metabolism; D064231:Nestin; D055495:Neurogenesis / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D011247:Pregnancy; D011506:Proteins / Q000235:genetics / Q000378:metabolism; D022661:RNA, Untranslated; D011827:Radiation; D011960:Receptors, Estrogen / Q000819:agonists / Q000235:genetics; D055748:SOXB1 Transcription Factors / Q000378:metabolism; D055153:Stem Cell Niche / Q000502:physiology*; D013629:Tamoxifen / Q000031:analogs & derivatives / Q000494:pharmacology
chemical_list: D001426:Bacterial Proteins; D001973:Bromodeoxyuridine; D051959:ELAV Proteins; D006657:Histones; D007381:Intermediate Filament Proteins; D008164:Luminescent Proteins; D009419:Nerve Tissue Proteins; D064231:Nestin; D011506:Proteins; D022661:RNA, Untranslated; D011960:Receptors, Estrogen; D055748:SOXB1 Transcription Factors; D013629:Tamoxifen; C110853:Gt(ROSA)26Sor non-coding RNA, mouse; C577485:Nes protein, mouse; C527783:Sox2 protein, mouse; C054562:yellow fluorescent protein, Bacteria; C016601:afimoxifene; C475961:gamma-H2AX protein, mouse