title: Highly efficient disulfide bridging polymers for bioconjugates from radical-compatible dithiophenol maleimides.
abstract: The direct synthesis of dithiophenol maleimide functional polymers by living radical polymerisation is described without the need for protecting group chemistry. The synthesised polymers have been successfully employed as disulfide bridging agents for salmon calcitonin when used in equimolar quantities, negating the requirement for complex purification strategies, traditionally associated with peptide bioconjugation.
authors.affiliation: Department of Chemistry, University of Warwick, Coventry, UK CV4 7AL.
authors.forename: Mathew W
authors.initials: MW
authors.lastname: Jones
authors.forename: Rachel A
authors.initials: RA
authors.lastname: Strickland
authors.forename: Felix F
authors.initials: FF
authors.lastname: Schumacher
authors.forename: Stephen
authors.initials: S
authors.lastname: Caddick
authors.forename: James R
authors.initials: JR
authors.lastname: Baker
authors.forename: Matthew I
authors.initials: MI
authors.lastname: Gibson
authors.forename: David M
authors.initials: DM
authors.lastname: Haddleton
mesh_terms: D000818:Animals; D002116:Calcitonin / Q000737:chemistry*; D004220:Disulfides / Q000138:chemical synthesis / Q000737:chemistry*; D008301:Maleimides / Q000138:chemical synthesis / Q000737:chemistry*; D008958:Models, Molecular; D019800:Phenol / Q000138:chemical synthesis / Q000737:chemistry*; D058105:Polymerization; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry*; D012474:Salmon; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D004220:Disulfides; D008301:Maleimides; D011108:Polymers; D013438:Sulfhydryl Compounds; C043592:maleimide; D019800:Phenol; D002116:Calcitonin