title: Mifepristone 2.5 mg versus 5 mg daily in the treatment of leiomyoma before surgery.
abstract: OBJECTIVE
  To evaluate the efficacy and safety of 2.5 mg and 5 mg mifepristone during 3 months for the treatment of uterine fibroids before surgery.
  
  
  METHODS
  Multicenter randomized clinical trial.
  
  
  METHODS
  Eusebio Hernández Hospital, Havana, Cuba and the Alemán Hospital, Managua, Nicaragua.
  
  
  METHODS
  Included in the study were 146 women with symptomatic uterine fibroids.
  
  
  METHODS
  GROUP I: half a tablet of 5 mg (2.5 mg) mifepristone taken orally every 24 hours, and Group II: one tablet of 5 mg mifepristone taken orally every 24 hours over a period of 3 months in both groups. Two endometrial biopsies were performed.  VARIABLES TO EVALUATE EFFICACY: Increase in average hemoglobin, changes in fibroid and uterine volume, and symptomatic improvement.
  
  
  RESULTS
  The average hemoglobin at the end of treatment was 0.6 g/dL greater in the 5 mg mifepristone group (P = 0.033). In both groups there were similar reductions in fibroid volumes. Clinical improvement was more significant in the 5 mg group.
  
  
  CONCLUSIONS
  The dose to be used should be 5 mg.
authors.affiliation: Mediterránea Médica Clinic, Valencia, Spain.
authors.forename: Josep L
authors.initials: JL
authors.lastname: Carbonell Esteve
authors.forename: Ana M
authors.initials: AM
authors.lastname: Riverón
authors.forename: Mariela
authors.initials: M
authors.lastname: Cano
authors.forename: Alma I
authors.initials: AI
authors.lastname: Ortiz
authors.forename: Aleta
authors.initials: A
authors.lastname: Valle
authors.forename: Carlos S
authors.initials: CS
authors.lastname: Texidó
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Tomasi