title: Histamine: an undercover agent in multiple rare diseases?
abstract: Histamine is a biogenic amine performing pleiotropic effects in humans, involving tasks within the immune and neuroendocrine systems, neurotransmission, gastric secretion, cell life and death, and development. It is the product of the histidine decarboxylase activity, and its effects are mainly mediated through four different G-protein coupled receptors. Thus, histamine-related effects are the results of highly interconnected and tissue-specific signalling networks. Consequently, alterations in histamine-related factors could be an important part in the cause of multiple rare/orphan diseases. Bearing this hypothesis in mind, more than 25 rare diseases related to histamine physiopathology have been identified using a computationally assisted text mining approach. These newly integrated data will provide insight to elucidate the molecular causes of these rare diseases. The data can also help in devising new intervention strategies for personalized medicine for multiple rare diseases.
authors.affiliation: Dpto. Biología Molecular y Bioquímica, Universidad de Málaga, Málaga, Spain.
authors.forename: Almudena
authors.initials: A
authors.lastname: Pino-Ángeles
authors.forename: Armando
authors.initials: A
authors.lastname: Reyes-Palomares
authors.forename: Esther
authors.initials: E
authors.lastname: Melgarejo
authors.forename: Francisca
authors.initials: F
authors.lastname: Sánchez-Jiménez
mesh_terms: D057225:Data Mining; D005750:Gastric Juice / Q000187:drug effects / Q000378:metabolism; D006632:Histamine / Q000378:metabolism*; D006640:Histidine Decarboxylase / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D009422:Nervous System Diseases / Q000503:physiopathology*; D035583:Rare Diseases / Q000378:metabolism / Q000503:physiopathology*; D043562:Receptors, G-Protein-Coupled / Q000187:drug effects / Q000378:metabolism; D011968:Receptors, Histamine / Q000187:drug effects / Q000378:metabolism; D015398:Signal Transduction; D009435:Synaptic Transmission / Q000187:drug effects; D049490:Systems Biology
chemical_list: D043562:Receptors, G-Protein-Coupled; D011968:Receptors, Histamine; D006632:Histamine; D006640:Histidine Decarboxylase