title: Sialoadhesin in recognition of self and non-self.
abstract: The immune system is tightly regulated to maintain an appropriate balance between immune activation and tolerance. Macrophages play a key role in this process since they express many pathogen recognition molecules as well as receptors for 'self'. Sialoadhesin is a major macrophage receptor that specifically recognizes sialic acid, an abundant component of host glycoconjugates but which can also be found on several human pathogens. In recent years, several studies have demonstrated that sialoadhesin can contribute to the uptake and processing of sialylated pathogens as well as playing an important role in regulating inflammatory and autoimmune responses via recognition of self.
authors.affiliation: Division of Cell Signalling and Immunology, College of Life Sciences, University of Dundee, Dundee, UK.
authors.forename: Mariliis
authors.initials: M
authors.lastname: Klaas
authors.forename: Paul R
authors.initials: PR
authors.lastname: Crocker
mesh_terms: D000818:Animals; D017951:Antigen Presentation; D015551:Autoimmunity; D006801:Humans; D007108:Immune Tolerance; D007249:Inflammation / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D051379:Mice; D019158:N-Acetylneuraminic Acid / Q000276:immunology; D051381:Rats; D063267:Sialic Acid Binding Ig-like Lectin 1 / Q000276:immunology* / Q000378:metabolism*; D013552:Swine
chemical_list: D063267:Sialic Acid Binding Ig-like Lectin 1; D019158:N-Acetylneuraminic Acid