title: [Hazard assessment of manufactured nanoparticles: association of in vitro and in vivo examinations].
abstract: Nanoparticles are defined as particles whose diameter is 1-100 nm. Many investigations about the toxicology of nanoparticles have been reported recently. The toxicity of nanoparticles has been examined both in vivo and in vitro and many results are being achieved. However, the results of in vivo and in vitro examinations are sometimes different. According to the in vitro examinations, it is suggested that solubility, adsorption ability and surface activity are involved in the cytotoxicity of nanoparticles. On the other hand, in in vivo, clearance is an important factor in the lung toxicity of nanoparticles. In the hazard assessment of nanoparticles, in vivo and in vitro examinations are necessary for an accurate evaluation of their biological influences, including the toxic mechanisms.
authors.affiliation: Department of Occupational Pneumology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Japan.
authors.forename: Masanori
authors.initials: M
authors.lastname: Horie
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Morimoto
mesh_terms: D000327:Adsorption; D000818:Animals; D066298:In Vitro Techniques; D008168:Lung / Q000187:drug effects; D053758:Nanoparticles / Q000009:adverse effects*; D012995:Solubility