title: Evaluation of a midazolam-ketamine-xylazine infusion for total intravenous anesthesia in horses.
abstract: OBJECTIVE
  To evaluate the use of midazolam, ketamine, and xylazine for total IV anesthesia (TIVA) in horses.
  
  
  METHODS
  6 healthy Thoroughbred mares.
  
  
  METHODS
  Horses were sedated with xylazine (1.0 mg/kg, IV). Anesthesia was induced with midazolam (0.1 mg/kg, IV) followed by ketamine (2.2 mg/kg, IV) and was maintained with an IV infusion of midazolam (0.002 mg/kg/min), ketamine (0.03 mg/kg/min), and xylazine (0.016 mg/kg/min). Horses underwent surgical manipulation and injection of the palmar digital nerves; duration of the infusion was 60 minutes. Additional ketamine (0.2 to 0.4 mg/kg, IV) was administered if a horse moved its head or limbs during procedures. Cardiopulmonary and arterial blood variables were measured prior to anesthesia; at 10, 20, 30, 45, and 60 minutes during infusion; and 10 minutes after horses stood during recovery. Recovery quality was assessed by use of a numeric (1 to 10) scale with 1 as an optimal score.
  
  
  RESULTS
  Anesthesia was produced for 70 minutes after induction; supplemental ketamine administration was required in 4 horses. Heart rate, respiratory rate, arterial blood pressures, and cardiac output remained similar to preanesthetic values throughout TIVA. Arterial partial pressure of oxygen and oxygen saturation of arterial hemoglobin were significantly decreased from preanesthetic values throughout anesthesia; oxygen delivery was significantly decreased at 10- to 30-minute time points. Each horse stood on its first attempt, and median recovery score was 2.
  
  
  CONCLUSIONS
  Midazolam, ketamine, and xylazine in combination produced TIVA in horses. Further studies to investigate various dosages for midazolam and ketamine or the substitution of other α(2)-adrenoceptor for xylazine are warranted.
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH 43210, USA. john.hubbell@cvm.osu.edu
authors.forename: John A E
authors.initials: JA
authors.lastname: Hubbell
authors.forename: Turi K
authors.initials: TK
authors.lastname: Aarnes
authors.forename: Phillip
authors.initials: P
authors.lastname: Lerche
authors.forename: Richard M
authors.initials: RM
authors.lastname: Bednarski
mesh_terms: D000762:Anesthesia Recovery Period; D000768:Anesthesia, General / Q000662:veterinary*; D000771:Anesthesia, Intravenous / Q000662:veterinary; D000778:Anesthetics, Dissociative / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004359:Drug Therapy, Combination; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006736:Horses; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000494:pharmacology; D007649:Ketamine / Q000008:administration & dosage / Q000494:pharmacology*; D008874:Midazolam / Q000008:administration & dosage / Q000494:pharmacology*; D010100:Oxygen / Q000097:blood; D056152:Respiratory Rate / Q000187:drug effects; D014991:Xylazine / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000778:Anesthetics, Dissociative; D006993:Hypnotics and Sedatives; D014991:Xylazine; D007649:Ketamine; D008874:Midazolam; D010100:Oxygen