title: Physicochemical performances of indomethacin in cholesteryl cetyl carbonate liquid crystal as a transdermal dosage.
abstract: A transdermal formulation of indomethacin (IMC) was developed by incorporation into cholesteryl cetyl carbonate (CCC). The liquid crystalline phase properties of the IMC-CCC mixture were detected by polarized light microscopy and differential scanning calorimetry. A low drug loading was obtained (1-5 %) similar to that used in conventional topical IMC in a clinical setting. A controlled release of IMC was found over 12 h. A low amount of IMC in 1 % IMC-CCC permeated the stratum corneum. Further formulation development has been carried out by the addition of lauryl alcohol into 5 % IMC-CCC mixture it was found that the permeation of IMC was significantly improved to 45 % within 24 h.
authors.affiliation: Drug Delivery System Excellence Center, Prince of Songkla University, Hat Yai, Songkla, 90112, Thailand.
authors.forename: Nunchanit
authors.initials: N
authors.lastname: Aeinleng
authors.forename: Sarunyou
authors.initials: S
authors.lastname: Songkro
authors.forename: Kusumarn
authors.initials: K
authors.lastname: Noipha
authors.forename: Teerapol
authors.initials: T
authors.lastname: Srichana
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D000831:Animals, Newborn; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism; D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D002788:Cholesterol Esters / Q000737:chemistry*; D003692:Delayed-Action Preparations; D007851:Dodecanol / Q000737:chemistry; D004337:Drug Carriers; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D007213:Indomethacin / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism; D007700:Kinetics; D050866:Liquid Crystals; D008859:Microscopy, Polarization; D010539:Permeability; D012867:Skin / Q000378:metabolism; D012869:Skin Absorption; D012881:Skin Temperature; D012995:Solubility; D013552:Swine; D013678:Technology, Pharmaceutical / Q000379:methods; D044366:Transition Temperature
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002788:Cholesterol Esters; D003692:Delayed-Action Preparations; D004337:Drug Carriers; C575352:cholesteryl cetyl carbonate; D007851:Dodecanol; D007213:Indomethacin