title: Anaemia and prognosis in acute coronary syndromes: a systematic review and meta-analysis.
abstract: OBJECTIVE
  This meta-analysis was conducted to summarize the association between anaemia and outcomes in patients with acute coronary syndromes (ACS).
  
  
  METHODS
  MEDLINE®, Cochrane Library, OVID and EMBASE databases were searched to identify studies that examined the effect of anaemia on mortality or other adverse events (heart failure, cardiogenic shock or major bleeding).
  
  
  RESULTS
  Nineteen studies met the final inclusion criteria (total number of patients 241 293). The risks of shortterm mortality (odds ratio [OR] 2.77; 95% confidence interval [CI] 2.09, 3.65), long-term mortality (OR 2.03; 95% CI 1.52, 2.71), heart failure (OR 1.96; 95% CI 1.47, 2.62), cardiogenic shock (OR 1.95; 95% CI 1.04, 2.64) and major bleeding (OR 4.28; 95% CI 1.05, 17.14) were increased in patients with anaemia, compared with patients without anaemia. Anaemia was also associated with a higher risk of mortality (adjusted hazard ratio 1.49, 95% CI 1.24, 1.79).
  
  
  CONCLUSIONS
  These study findings suggest that anaemia can be used to identify patients with ACS who are at a high risk of death or adverse events, and it may become a promising risk stratification factor in ACS.
authors.affiliation: Emergency Centre of Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.forename: Y M
authors.initials: YM
authors.lastname: Yang
authors.forename: J
authors.initials: J
authors.lastname: Zhu
authors.forename: H Q
authors.initials: HQ
authors.lastname: Tan
authors.forename: Y
authors.initials: Y
authors.lastname: Liang
authors.forename: J D
authors.initials: JD
authors.lastname: Li
mesh_terms: D054058:Acute Coronary Syndrome / Q000150:complications* / Q000175:diagnosis*; D000740:Anemia / Q000150:complications*; D006801:Humans; D011379:Prognosis; D012307:Risk Factors