title: Maternally-derived antibody to fibroblast growth factor-23 reduced dietary phosphate requirements in growing chicks.
abstract: Phosphate in manure of monogastric animals pollutes the environment if improperly applied to soil. Strategies that reduce phosphate inputs into animal production systems reduce environmental pollution. Using a novel vaccine to fibroblast growth factor-23 (FGF-23), we induced neutralizing antibodies that reduced the phosphate requirement of growing chickens. Breeding hens were injected with a FGF-23 peptide (AFLPGMNP) conjugate. Antibody was passively transferred from hen to chick and chick response to deficient dietary phosphate intake was determined. Chicks without passive anti-FGF-23 antibody had a 43% and 21% reduction in blood phosphate and bone ash, respectively, when fed a phosphate deficient diet and compared to chicks fed a phosphate replete diet (P<0.05). Chicks with circulating anti-FGF-23 antibodies fed the phosphate deficient diet had plasma phosphate and bone ash that did not differ from chicks fed the phosphate replete diet (P>0.05). Neutralization of FGF-23 offers a new approach to reduce phosphate requirements of farmed animals and may provide a new means to reduce phosphate pollution related to animal farming.
authors.affiliation: Animal Sciences Department, 1675 Observatory Drive, University of Wisconsin-Madison, Madison, WI 53706, USA.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Bobeck
authors.forename: Kimberly S
authors.initials: KS
authors.lastname: Burgess
authors.forename: Taylor R
authors.initials: TR
authors.lastname: Jarmes
authors.forename: Michelle L
authors.initials: ML
authors.lastname: Piccione
authors.forename: Mark E
authors.initials: ME
authors.lastname: Cook
mesh_terms: D000821:Animal Feed; D000824:Animal Nutritional Physiological Phenomena / Q000276:immunology*; D000818:Animals; D000906:Antibodies / Q000276:immunology*; D002645:Chickens / Q000097:blood / Q000254:growth & development* / Q000378:metabolism; D004785:Environmental Pollutants / Q000032:analysis*; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000737:chemistry / Q000276:immunology*; D006801:Humans; D008372:Manure / Q000032:analysis*; D009751:Nutritional Requirements; D010710:Phosphates / Q000032:analysis* / Q000097:blood / Q000378:metabolism; D017433:Protein Structure, Secondary
chemical_list: D000906:Antibodies; D004785:Environmental Pollutants; C000717427:FGF23 protein, human; D008372:Manure; D010710:Phosphates; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23