title: Octanoic acid suppresses harmaline-induced tremor in mouse model of essential tremor.
abstract: Recent work exploring the use of high-molecular weight alcohols to treat essential tremor (ET) has identified octanoic acid as a potential novel tremor-suppressing agent. We used an established harmaline-based mouse model of ET to compare tremor suppression by 1-octanol and octanoic acid. The dose-related effect on digitized motion power within the tremor bandwidth as a fraction of overall motion power was analyzed. Both 1-octanol and octanoic acid provided significant reductions in harmaline tremor. An 8-carbon alkyl alcohol and carboxylic acid each suppress tremor in a pre-clinical mouse model of ET. Further studies are warranted to determine the safety and efficacy of such agents in humans with ET.
authors.affiliation: Department of Neurology, University of Miami Miller School of Medicine, Miami, FL 33136, USA. fnahab@med.miami.edu
authors.forename: Fatta B
authors.initials: FB
authors.lastname: Nahab
authors.forename: Adrian
authors.initials: A
authors.lastname: Handforth
authors.forename: Tyler
authors.initials: T
authors.lastname: Brown
authors.forename: Christopher
authors.initials: C
authors.lastname: Shin
authors.forename: Arnulfo
authors.initials: A
authors.lastname: Quesada
authors.forename: Chuanhui
authors.initials: C
authors.lastname: Dong
authors.forename: Dietrich
authors.initials: D
authors.lastname: Haubenberger
authors.forename: Mark
authors.initials: M
authors.lastname: Hallett
mesh_terms: D000818:Animals; D002210:Caprylates / Q000627:therapeutic use*; D000697:Central Nervous System Stimulants / Q000633:toxicity*; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D020329:Essential Tremor / Q000139:chemically induced* / Q000188:drug therapy*; D006246:Harmaline / Q000633:toxicity*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR
chemical_list: D002210:Caprylates; D000697:Central Nervous System Stimulants; D006246:Harmaline; C031492:octanoic acid