title: Drimane-type sesquiterpenes with a dioxabicyclooctane skeleton from the fruiting bodies of Nigrofomes melanoporus and their cytotoxicity.
abstract: Two new drimane-type compounds, nigrofomins A ( 1) and B ( 2), possessing a rare dioxabicyclooctane moiety, were purified from the fruiting bodies of Nigrofomes melanoporus. Their structures were determined using 1D-, 2D-NMR and HR-ESI-MS spectroscopic analyses. In addition, 1 was established by X-ray crystallographic studies. Both nigrofomins A ( 1) and B ( 2) exhibited cytotoxicity on acute T-cell leukemia (Jurkat), human nasopharyngeal carcinoma (NPC-TW01), and lung cancer (NCI-H661) cells with IC (50) values in the range of 99.44-246.32 µM. Furthermore, the effects of 1 and 2 on cell-cycle progression of Jurkat cells displayed a concentration-dependent accumulation in the G (0)/G (1) phase.
authors.affiliation: Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung, Taiwan.
authors.forename: Hsiu-Hui
authors.initials: HH
authors.lastname: Chan
authors.forename: Shin-Hun
authors.initials: SH
authors.lastname: Juang
authors.forename: Tran Dinh
authors.initials: TD
authors.lastname: Thang
authors.forename: Min-Yu
authors.initials: MY
authors.lastname: Chen
authors.forename: Ping-Chung
authors.initials: PC
authors.lastname: Kuo
authors.forename: Mei-Lin
authors.initials: ML
authors.lastname: Yang
authors.forename: Nguyen Thi
authors.initials: NT
authors.lastname: Ngan
authors.forename: Nguyen Ngoc
authors.initials: NN
authors.lastname: Linh
authors.forename: Tian-Shung
authors.initials: TS
authors.lastname: Wu
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects; D045744:Cell Line, Tumor; D055453:Coriolaceae / Q000737:chemistry; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D048690:Fruiting Bodies, Fungal / Q000737:chemistry; D006801:Humans; D020128:Inhibitory Concentration 50; D019169:Jurkat Cells / Q000187:drug effects; D008175:Lung Neoplasms / Q000188:drug therapy; D008968:Molecular Conformation; D009303:Nasopharyngeal Neoplasms / Q000188:drug therapy; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014744:Vietnam
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D012717:Sesquiterpenes; C575485:nigrofomin A; C575486:nigrofomin B