title: A highly enantioselective approach towards 2-substituted 3-bromopyrrolidines.
abstract: A facile and highly enantioselective approach towards 2-substituted 3-bromopyrrolidines has been developed. The process involves an amino-thiocarbamate catalyzed bromoaminocyclization of 1,2-disubstituted olefinic amides. The pyrrolidine products could readily be converted into other useful building blocks including a dihydropyrrole and a 2-substituted pyrrolidine.
authors.affiliation: Department of Chemistry, National University of Singapore, Singapore.
authors.forename: Jie
authors.initials: J
authors.lastname: Chen
authors.forename: Ling
authors.initials: L
authors.lastname: Zhou
authors.forename: Ying-Yeung
authors.initials: YY
authors.lastname: Yeung
mesh_terms: D017605:Bromine Compounds / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D008958:Models, Molecular; D015394:Molecular Structure; D011759:Pyrrolidines / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D017605:Bromine Compounds; D011759:Pyrrolidines; C032519:pyrrolidine