title: Mechanisms for hepatoprotective effects of hyaluronidase immobilized by the nanotechnology method of electron-beam synthesis.
abstract: Immobilized hyaluronidase (nanotechnology method of electron-beam synthesis) exhibited high hepatoprotective activity on the model of Cl4-induced hepatitis. This agent produced anticholestatic, anti-inflammatory, and antisclerotic effects. These effects were shown to accompany stimulation of multipotent bone marrow precursors, mobilization of these cells into the peripheral blood, and cell migration to the target organ increasing the number of parenchymal progenitor cells in the liver. The mechanisms for targeted migration of progenitor cells suggest a decrease in SDF-1 production by bone marrow stromal cells and increase in the synthesis of this factor by microenvironmental cells of the liver tissue.
authors.affiliation: Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia.
authors.forename: A M
authors.initials: AM
authors.lastname: Dygai
authors.forename: G N
authors.initials: GN
authors.lastname: Zyuzkov
authors.forename: V V
authors.initials: VV
authors.lastname: Zhdanov
authors.forename: E V
authors.initials: EV
authors.lastname: Udut
authors.forename: A V
authors.initials: AV
authors.lastname: Artamonov
authors.forename: A A
authors.initials: AA
authors.lastname: Bekarev
authors.forename: P G
authors.initials: PG
authors.lastname: Madonov
authors.forename: D N
authors.initials: DN
authors.lastname: Kinsht
authors.forename: L A
authors.initials: LA
authors.lastname: Miroshnichenko
authors.forename: T Yu
authors.initials: TY
authors.lastname: Khrichkova
authors.forename: E V
authors.initials: EV
authors.lastname: Simanina
authors.forename: L A
authors.initials: LA
authors.lastname: Stavrova
authors.forename: A V
authors.initials: AV
authors.lastname: Chaikovskiy
authors.forename: T S
authors.initials: TS
authors.lastname: Markova
authors.forename: M Yu
authors.initials: MY
authors.lastname: Minakova
authors.forename: R V
authors.initials: RV
authors.lastname: Gurto
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects; D002251:Carbon Tetrachloride; D002465:Cell Movement / Q000187:drug effects; D060833:Cellular Microenvironment / Q000187:drug effects; D054377:Chemokine CXCL12 / Q000378:metabolism; D019610:Cytoprotection; D004800:Enzymes, Immobilized / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D006520:Hepatitis, Animal / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D006821:Hyaluronoglucosaminidase / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D051379:Mice; D039902:Multipotent Stem Cells / Q000166:cytology / Q000187:drug effects*; D036103:Nanotechnology; D051381:Rats; D017154:Stromal Cells / Q000166:cytology / Q000187:drug effects
chemical_list: D015415:Biomarkers; D054377:Chemokine CXCL12; C515256:Cxcl12 protein, mouse; D004800:Enzymes, Immobilized; D002251:Carbon Tetrachloride; D006821:Hyaluronoglucosaminidase