title: Synthesis and antiviral activity of a series of 1'-substituted 4-aza-7,9-dideazaadenosine C-nucleosides.
abstract: A series of 1'-substituted analogs of 4-aza-7,9-dideazaadenosine C-nucleoside were prepared and evaluated for the potential as antiviral agents. These compounds showed a broad range of inhibitory activity against various RNA viruses. In particular, the whole cell potency against HCV when R=CN was attributed to inhibition of HCV NS5B polymerase and intracellular concentration of the corresponding nucleoside triphosphate.
authors.affiliation: Gilead Sciences, 333 Lakeside Drive, Foster Cit, CA 94044, USA. acho@gilead.com
authors.forename: Aesop
authors.initials: A
authors.lastname: Cho
authors.forename: Oliver L
authors.initials: OL
authors.lastname: Saunders
authors.forename: Thomas
authors.initials: T
authors.lastname: Butler
authors.forename: Lijun
authors.initials: L
authors.lastname: Zhang
authors.forename: Jie
authors.initials: J
authors.lastname: Xu
authors.forename: Jennifer E
authors.initials: JE
authors.lastname: Vela
authors.forename: Joy Y
authors.initials: JY
authors.lastname: Feng
authors.forename: Adrian S
authors.initials: AS
authors.lastname: Ray
authors.forename: Choung U
authors.initials: CU
authors.lastname: Kim
mesh_terms: D000241:Adenosine / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001372:Aza Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D016174:Hepacivirus / Q000187:drug effects*; D006801:Humans; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D017361:Viral Nonstructural Proteins / Q000037:antagonists & inhibitors / Q000187:drug effects; D012324:RNA-Dependent RNA Polymerase
chemical_list: D000241:Adenosine; D000998:Antiviral Agents; D001372:Aza Compounds; D009705:Nucleosides; D017361:Viral Nonstructural Proteins; C087036:NS-5 protein, hepatitis C virus; D012324:RNA-Dependent RNA Polymerase