title: Fos protein-like immunoreactive neurons induced by electrical stimulation in the trigeminal sensory nuclear complex of rats with chronically injured peripheral nerve.
abstract: The rat trigeminal sensory nuclear complex (TSNC) was examined for Fos protein-like immunoreactive (Fos-LI) neurons induced by electrical stimulation (ES) of the lingual nerve (LN) at 2 weeks after injury to the LN or the inferior alveolar nerve (IAN). Intensity-dependent increase in the number of Fos-LI neurons was observed in the subnucleus oralis (Vo) and caudalis (Vc) of the spinal trigeminal tract nucleus irrespective of nerve injury. The number of Fos-LI neurons induced by ES of the chronically injured LN at A-fiber intensity (0.1 mA) was significantly increased in the Vo but not the Vc. On the other hand, in rats with chronically injured IAN, the number of Fos-LI neurons induced by ES of the LN at C-fiber intensity (10 mA) was significantly increased in the Vc but not the Vo. These results indicated that injury of a nerve innervating intraoral structures increased the c-Fos response of Vo neurons to A-fiber intensity ES of the injured nerve. A similar nerve injury enhanced the c-Fos response of Vc neurons to C-fiber intensity ES of a spared uninjured nerve innervating an intraoral territory neighboring that of the injured nerve. The present result show that nerve injury causes differential effects on c-Fos expression in the Vo and Vc, which may explain complexity of neuropathic pain symptoms in clinical cases.
authors.affiliation: Department of Oral Function and Anatomy, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Kita-ku, Okayama 700-8525, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Fujisawa
authors.forename: Ryuji
authors.initials: R
authors.lastname: Terayama
authors.forename: Daisuke
authors.initials: D
authors.lastname: Yamaguchi
authors.forename: Shinji
authors.initials: S
authors.lastname: Omura
authors.forename: Takashi
authors.initials: T
authors.lastname: Yamashiro
authors.forename: Tomosada
authors.initials: T
authors.lastname: Sugimoto
mesh_terms: D000818:Animals; D002908:Chronic Disease; D004558:Electric Stimulation / Q000379:methods; D061222:Lingual Nerve Injuries / Q000378:metabolism* / Q000473:pathology; D008297:Male; D055495:Neurogenesis / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014278:Trigeminal Nuclei / Q000378:metabolism*
chemical_list: D016760:Proto-Oncogene Proteins c-fos