title: [Monitoring of implementation of international programs of poliomyelitis eradication and measles and rubella elimination in the Republic of Belarus].
abstract: OBJECTIVE
  Monitoring of implementation of international programs of poliomyelitis eradication, and measles and rubella elimination in the Republic of Belarus based on results of molecular-epidemiologic studies of 2009 - 2010.
  
  
  METHODS
  271 viral agents isolated from children with acute flaccid paralysis syndrome, other diseases, healthy children and from sewage water within the framework of poliomyelitis control implementation were identified by serological and molecular methods. Blood sera of 528 patients with fever and rash were examined for the presence of IgM to measles and rubella virus, 418 - for the presence of IgM to parvovirus B19 and parvovirus DNA. Blood sera of 33 pregnant women and 64 children with signs of intrauterine infection were studied for IgM and IgG antibodies to rubella virus. Measles virus was isolated, N-gene sequence and phylogenetic analysis carried out.
  
  
  RESULTS
  The studies performed confirmed that indigenous wild polioviruses in the country do not circulate, imported wild or vaccine-related polioviruses were also not detected. Measles and rubella morbidity in the Republic of Belarus was less than 1 in 1 000 000. 2 cases of rubella (2009) and 1 case of measles (2010) was detected during adequate control level: the rate of detection of patients with fever and rash, in whom measles and rubella diagnosis was excluded by the results of laboratory examination, was more than 2 in 100 000 of the population. The etiologic agent in more than 20% of diseases with fever and rash was parvovirus B19. A single case of measles was caused by genotype D8 virus imported from India.
  
  
  CONCLUSIONS
  The data obtained give evidence to conformance of the poliomyelitis, measles, rubella, innate rubella syndrome control implemented in the Republic of Belarus to WHO recommendations; maintenance of status of country as free from poliomyelitis and achievement of main criteria of elimination of both measles and rubella by 2010.
mesh_terms: D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood; D002648:Child; D002675:Child, Preschool; D060740:Disease Eradication / Q000458:organization & administration; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D007223:Infant; D008457:Measles / Q000097:blood / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D008459:Measles virus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D010322:Parvoviridae Infections / Q000097:blood / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D016732:Parvovirus B19, Human / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D010802:Phylogeny; D011051:Poliomyelitis / Q000097:blood / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D017955:Poliovirus / Q000276:immunology; D011159:Population Surveillance; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000517:prevention & control* / Q000821:virology; D002094:Republic of Belarus / Q000453:epidemiology; D012409:Rubella / Q000097:blood / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D012412:Rubella virus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D014611:Vaccination; D014765:Viral Vaccines / Q000008:administration & dosage*
chemical_list: D000914:Antibodies, Viral; D007075:Immunoglobulin M; D014765:Viral Vaccines