title: Preventive and curative effects of Achyranthes aspera Linn. extract in experimentally induced nephrolithiasis.
abstract: The present study was undertaken to evaluate the efficacy of Achyranthes aspera in preventing and reducing the growth of calcium oxalate stones in ethylene glycol induced nephrolithiatic model. Hyperoxaluria was induced in rats using ethylene glycol (EG, 0.4%) and ammonium chloride (1%) for 15 days and was then replaced with EG (0.4%) only. Upon administration of cystone (750 mg/kg body wt.), aqueous extract of A. aspera (500 and 1000 mg/kg body wt.), levels of renal injury markers (lactate dehydrogenase and alkaline phosphatase) were normalized with a decrease in serum urea and serum creatinine. Concurrent treatment reduced changes in the architecture of renal tissue and also decreased the size of crystals thereby helping in quick expulsion of the crystals. The present results indicated that Achyranthes aspera had an ability to maintain renal functioning and reduced renal injury.
authors.affiliation: Department of Biotechnology and Bioinformatics, Jaypee University of Information Technology, Waknaghat 173 234, Solan, India.
authors.forename: Anshu
authors.initials: A
authors.lastname: Aggarwal
authors.forename: Surinder K
authors.initials: SK
authors.lastname: Singla
authors.forename: Manish
authors.initials: M
authors.lastname: Gandhi
authors.forename: Chanderdeep
authors.initials: C
authors.lastname: Tandon
mesh_terms: D029044:Achyranthes / Q000737:chemistry*; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D004195:Disease Models, Animal; D019855:Ethylene Glycol / Q000494:pharmacology*; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008297:Male; D053040:Nephrolithiasis / Q000139:chemically induced* / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control*; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D015415:Biomarkers; D010936:Plant Extracts; D019855:Ethylene Glycol