title: A new heart: somatic stem cells and myocardial regeneration.
abstract: End-stage heart failure is a global scourge. Current therapies merely delay its inexorable progression. Heart transplantation is resource-intensive and limited by organ availability. Bone marrow-derived and cardiac-specific stem cells have demonstrated potential for cardiac regeneration and repair, but the magnitude and durability of these promising findings are inconsistent. The purpose of this review is to (1) describe cells currently being investigated, (2) outline the status of current trials, and (3) discuss key objectives of future research.
authors.affiliation: Department of Surgery, Veterans Affairs Medical Center, Washington, District of Columbia, Washington, District of Columbia 20307, USA. philip.mullenix@va.gov
authors.forename: Philip S
authors.initials: PS
authors.lastname: Mullenix
authors.forename: Steven J
authors.initials: SJ
authors.lastname: Huddleston
authors.forename: Alexander
authors.initials: A
authors.lastname: Stojadinovic
authors.forename: Gregory D
authors.initials: GD
authors.lastname: Trachiotis
authors.forename: Edmund P
authors.initials: EP
authors.lastname: Alexander
mesh_terms: D053687:Adult Stem Cells / Q000637:transplantation*; D015906:Angioplasty, Balloon, Coronary; D000818:Animals; D016026:Bone Marrow Transplantation; D002986:Clinical Trials as Topic; D001026:Coronary Artery Bypass; D006333:Heart Failure / Q000209:etiology* / Q000503:physiopathology / Q000601:surgery*; D016027:Heart Transplantation / Q000266:history / Q000639:trends; D049673:History, 20th Century; D006801:Humans; D009203:Myocardial Infarction / Q000150:complications / Q000503:physiopathology; D009206:Myocardium / Q000473:pathology; D012038:Regeneration; D033581:Stem Cell Transplantation; D013318:Stroke Volume; D057170:Translational Research, Biomedical / Q000639:trends; D016896:Treatment Outcome