title: Molecular alterations associated with osteosarcoma development.
abstract: Osteosarcoma is the most frequent malignant primary bone tumor characterized by a high potency to form lung metastases which is the main cause of death. Unfortunately, the conventional chemotherapy is not fully effective on osteosarcoma metastases. The progression of a primary tumor to metastasis requires multiple processes, which are neovascularization, proliferation, invasion, survival in the bloodstream, apoptosis resistance, arrest at a distant organ, and outgrowth in secondary sites. Consequently, recent studies have revealed new insights into the molecular mechanisms of metastasis development. The understanding of the mechanism of molecular alterations can provide the identification of novel therapeutic targets and/or prognostic markers for osteosarcoma treatment to improve the clinical outcome.
authors.affiliation: INSERM, UMR-S 957, 1 Rue Gaston Veil, 44035 Nantes, France.
authors.forename: Kosei
authors.initials: K
authors.lastname: Ando
authors.forename: Kanji
authors.initials: K
authors.lastname: Mori
authors.forename: Franck
authors.initials: F
authors.lastname: Verrecchia
authors.forename: Baud'huin
authors.initials: B
authors.lastname: Marc
authors.forename: Françoise
authors.initials: F
authors.lastname: Rédini
authors.forename: Dominique
authors.initials: D
authors.lastname: Heymann