title: FMS Kinase Inhibitors: Current Status and Future Prospects.
abstract: FMS, first discovered as the oncogene responsible for Feline McDonough Sarcoma, is a type III receptor tyrosine kinase that binds to the macrophage or monocyte colony-stimulating factor (M-CSF or CSF-1). Signal transduction through that binding results in survival, proliferation, and differentiation of monocyte/macrophage lineage. Overexpression of CSF-1 and/or FMS has been implicated in a number of disease states such as the growth of metastasis of certain types of cancer, in promoting osteoclast proliferation in bone osteolysis, and many inflammatory disorders. Inhibition of CSF-1 and/or FMS may help treat these pathological conditions. This article reviews FMS gene, FMS kinase, CSF-1, IL-34, and their roles in bone osteolysis, cancer biology, and inflammation. Monoclonal antibodies, FMS crystal structure, and small molecule FMS kinase inhibitors of different chemical scaffolds are also reviewed.
authors.affiliation: Biomedical Research Institute, Korea Institute of Science and Technology, P.O. Box 131, Cheongryang, Seoul 130-650, Republic of Korea.
authors.forename: Mohammed I
authors.initials: MI
authors.lastname: El-Gamal
authors.forename: Hanan S
authors.initials: HS
authors.lastname: Anbar
authors.forename: Kyung Ho
authors.initials: KH
authors.lastname: Yoo
authors.forename: Chang-Hyun
authors.initials: CH
authors.lastname: Oh
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000737:chemistry / Q000627:therapeutic use; D003460:Crystallization; D016236:Genes, fms / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D007378:Interleukins / Q000502:physiology; D016173:Macrophage Colony-Stimulating Factor / Q000276:immunology / Q000502:physiology; D009369:Neoplasms / Q000503:physiopathology; D010014:Osteolysis / Q000503:physiopathology; D047428:Protein Kinase Inhibitors / Q000737:chemistry / Q000145:classification; D016186:Receptor, Macrophage Colony-Stimulating Factor / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000276:immunology / Q000502:physiology
chemical_list: D000911:Antibodies, Monoclonal; C529076:IL34 protein, human; D007378:Interleukins; D047428:Protein Kinase Inhibitors; D016173:Macrophage Colony-Stimulating Factor; D016186:Receptor, Macrophage Colony-Stimulating Factor