title: Fibrillisation of ring-closed amyloid peptides.
abstract: Ring-closing olefin metathesis reactions are used to create intra-molecularly ring closed peptides or inter-molecularly ring-closed peptide dimers based on a designed amyloid peptide sequence. The uncrosslinked peptide self-assembles into high aspect ratio nanotubes, however ring-closing leads to the formation of fibrillar and twisted/helical ribbon structures.
authors.affiliation: Dept of Chemistry, University of Reading, Whiteknights Reading RG6 6AD, UK. I.W.Hamley@reading.ac.uk
authors.forename: Ian W
authors.initials: IW
authors.lastname: Hamley
authors.forename: Ge
authors.initials: G
authors.lastname: Cheng
authors.forename: Valeria
authors.initials: V
authors.lastname: Castelletto
authors.forename: Stephan
authors.initials: S
authors.lastname: Handschin
authors.forename: Raffaele
authors.initials: R
authors.lastname: Mezzenga
mesh_terms: D000475:Alkenes / Q000737:chemistry; D000682:Amyloid / Q000737:chemistry*; D003500:Cyclization; D046529:Microscopy, Electron, Transmission; D045333:Nanotubes, Peptide / Q000737:chemistry* / Q000648:ultrastructure; D009842:Oligopeptides / Q000737:chemistry*
chemical_list: D000475:Alkenes; D000682:Amyloid; D045333:Nanotubes, Peptide; D009842:Oligopeptides