title: Pharmacological suppression of corticosterone secretion in response to a physical stressor does not prevent the delayed persistent increase in circulating basal corticosterone concentration.
abstract: Elevated basal plasma corticosterone concentrations have been observed for several days after the cessation of severe stress. In the present study, we examined whether or not the acute plasma corticosterone response to stress is necessary to elicit increased basal plasma corticosterone concentrations the following day. Pretreatment with metyrapone (100 m a g , intraperitoneal)1 h before inescapable stress (40 2mA tail shocks delivered over a 1-h period) (IS)blocked the acute plasma corticosterone response to IS. However, elevated basal plasma corticosterone concentrations still emerged the next day. These results suggest that the corticosterone response to stress, and its attendant feedback, are not necessary to produce persistent hypothalamic-pituitary-adrenal axis (HPAA) activation.
authors.affiliation: Neurobehavioral Unit, Department of Veterans Affairs Medical Center East Orange, NJ, USA.
authors.forename: R L
authors.initials: RL
authors.lastname: Moldow
authors.forename: K D
authors.initials: KD
authors.lastname: Beck
authors.forename: G
authors.initials: G
authors.lastname: Zhug
authors.forename: D
authors.initials: D
authors.lastname: Beldowicz
authors.forename: F X
authors.initials: FX
authors.lastname: Brennan
authors.forename: J E
authors.initials: JE
authors.lastname: Ottenweller
authors.forename: R J
authors.initials: RJ
authors.lastname: Servatius
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D002940:Circadian Rhythm / Q000187:drug effects; D003345:Corticosterone / Q000097:blood*; D004195:Disease Models, Animal; D004558:Electric Stimulation; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000494:pharmacology*; D025461:Feedback, Physiological; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects* / Q000378:metabolism; D007274:Injections, Intraperitoneal; D008297:Male; D008797:Metyrapone / Q000008:administration & dosage / Q000494:pharmacology*; D010913:Pituitary-Adrenal System / Q000187:drug effects* / Q000201:enzymology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013252:Steroid 11-beta-Hydroxylase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013315:Stress, Psychological / Q000097:blood* / Q000201:enzymology / Q000523:psychology; D013997:Time Factors; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D004791:Enzyme Inhibitors; D013252:Steroid 11-beta-Hydroxylase; D003345:Corticosterone; D008797:Metyrapone