title: Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis.
abstract: To find new candidate loci predisposing individuals to Kawasaki disease, an acute vasculitis that affects children, we conducted a genome-wide association study in 622 individuals with Kawasaki disease (cases) and 1,107 controls in a Han Chinese population residing in Taiwan, with replication in an independent Han Chinese sample of 261 cases and 550 controls. We report two new loci, one at BLK (encoding B-lymphoid tyrosine kinase) and one at CD40, that are associated with Kawasaki disease at genome-wide significance (P < 5 × 10(-8)). Our findings may lead to a better understanding of the role of immune activation and inflammation in Kawasaki disease pathogenesis.
authors.affiliation: Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
authors.forename: Yi-Ching
authors.initials: YC
authors.lastname: Lee
authors.forename: Ho-Chang
authors.initials: HC
authors.lastname: Kuo
authors.forename: Jeng-Sheng
authors.initials: JS
authors.lastname: Chang
authors.forename: Luan-Yin
authors.initials: LY
authors.lastname: Chang
authors.forename: Li-Min
authors.initials: LM
authors.lastname: Huang
authors.forename: Ming-Ren
authors.initials: MR
authors.lastname: Chen
authors.forename: Chi-Di
authors.initials: CD
authors.lastname: Liang
authors.forename: Hsin
authors.initials: H
authors.lastname: Chi
authors.forename: Fu-Yuan
authors.initials: FY
authors.lastname: Huang
authors.forename: Meng-Luen
authors.initials: ML
authors.lastname: Lee
authors.forename: Yhu-Chering
authors.initials: YC
authors.lastname: Huang
authors.forename: Betau
authors.initials: B
authors.lastname: Hwang
authors.forename: Nan-Chang
authors.initials: NC
authors.lastname: Chiu
authors.forename: Kao-Pin
authors.initials: KP
authors.lastname: Hwang
authors.forename: Pi-Chang
authors.initials: PC
authors.lastname: Lee
authors.forename: Li-Ching
authors.initials: LC
authors.lastname: Chang
authors.forename: Yi-Min
authors.initials: YM
authors.lastname: Liu
authors.forename: Ying-Ju
authors.initials: YJ
authors.lastname: Chen
authors.forename: Chien-Hsiun
authors.initials: CH
authors.lastname: Chen
authors.forename: Yuan-Tsong
authors.initials: YT
authors.lastname: Chen
authors.forename: Fuu-Jen
authors.initials: FJ
authors.lastname: Tsai
authors.forename: Jer-Yuarn
authors.initials: JY
authors.lastname: Wu
mesh_terms: D016022:Case-Control Studies; D056426:Genetic Loci; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D009080:Mucocutaneous Lymph Node Syndrome / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D013624:Taiwan
chemical_list: D005819:Genetic Markers