title: Chronic histiocytic intervillositis with cytomegalovirus placentitis in a case of hydrops fetalis.
abstract: Chronic histiocytic intervillositis (CHI) is an infrequent inflammatory placental disorder associated with unfavorable pregnancy outcomes and a high rate of recurrence. This disorder is thought to reflect a maternal delayed hypersensitivity response to fetal antigen(s) in placental tissue. We report a case of a 20-week-gestation hydropic fetus in which the placenta showed chronic histiocytic intervillositis with cytomegalovirus placentitis. Immunophenotyping studies supported a delayed hypersensitivity response. This is the first report of these two diseases co-occurring, raising the possibility of a relationship between chronic histiocytic intervillositis and infection. Chronic histiocytic intervillositis may represent an idiosyncratic immune response, in this case to cytomegalovirus.
authors.affiliation: Department of Pathology, Chulalongkorn University, Pathumwan, Bangkok, Thailand. dr.mana4@gmail.com
authors.forename: Mana
authors.initials: M
authors.lastname: Taweevisit
authors.forename: Kornkanok
authors.initials: K
authors.lastname: Sukpan
authors.forename: Sumalee
authors.initials: S
authors.lastname: Siriaunkgul
authors.forename: Paul Scott
authors.initials: PS
authors.lastname: Thorner
mesh_terms: D000328:Adult; D002824:Chorionic Villi / Q000473:pathology*; D002908:Chronic Disease; D003586:Cytomegalovirus Infections / Q000150:complications / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D005865:Gestational Age; D006644:Histiocytes / Q000473:pathology*; D006801:Humans; D015160:Hydrops Fetalis / Q000473:pathology* / Q000821:virology; D007249:Inflammation; D008297:Male; D010922:Placenta Diseases / Q000473:pathology* / Q000821:virology; D011247:Pregnancy; D011248:Pregnancy Complications; D050497:Stillbirth