title: Relationship between depression, clinical and biochemical parameters in patients undergoing haemodialysis.
abstract: In this paper, we investigated the incidence of depression and its relation to clinical, laboratory parameters and sleep disorders in 45 haemodialysis (HD) patients. They were divided into two groups. Group A (n = 29) had no depression, whereas Group B (n = 16) had clinically assessed depression. Subjects were compared in terms of socioeconomic, clinical, laboratory parameters and presence of sleep disorders. Groups were matched for age, sex, family status, education, self-esteem, coffee and alcohol consumption, psychiatric history, time on HD and laboratory (serum urea, creatinine, electrolytes, iron, albumin and lipids) parameters. Group B demonstrated significantly lower haemoglobin levels (11.13 ± 1.69 and 12.23 ± 1.31 g/dl, respectively; p < 0.01) and higher C-Reactive Protein (CRP) levels (1.82 ± 1.73 and 0.83 ± 0.6 mg/dl, respectively; p < 0.005) compared to Group A. Additionally, strong correlation was observed when Hamilton Depression Scale scores were related to haemoglobin (r =-0.30, p < 0.05), CRP (r = 0.38, p < 0.001) and AIS scores (r = 0.54, p < 0.0001). In conclusion, depression seems to be related to high CRP, low haemoglobin levels and sleep disorders.
authors.affiliation: Nephrology Department, General Hospital of Rhodes, Agioi Apostoloi, 85100 Rhodes, Greece.
authors.forename: Christina
authors.initials: C
authors.lastname: Bornivelli
authors.forename: Georgios
authors.initials: G
authors.lastname: Aperis
authors.forename: Ioannis
authors.initials: I
authors.lastname: Giannikouris
authors.forename: Christos
authors.initials: C
authors.lastname: Paliouras
authors.forename: Polichronis
authors.initials: P
authors.lastname: Alivanis
mesh_terms: D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism*; D015897:Comorbidity; D003430:Cross-Sectional Studies; D003866:Depressive Disorder / Q000453:epidemiology / Q000451:nursing* / Q000503:physiopathology* / Q000523:psychology; D005260:Female; D006452:Hemoglobinometry / Q000451:nursing*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000453:epidemiology / Q000451:nursing* / Q000503:physiopathology* / Q000523:psychology; D007677:Kidney Function Tests / Q000451:nursing*; D008297:Male; D008875:Middle Aged; D010555:Personality Inventory / Q000706:statistics & numerical data; D011594:Psychometrics; D006435:Renal Dialysis / Q000451:nursing* / Q000523:psychology; D012307:Risk Factors; D007319:Sleep Initiation and Maintenance Disorders / Q000453:epidemiology / Q000451:nursing* / Q000503:physiopathology / Q000523:psychology; D013223:Statistics as Topic
chemical_list: D002097:C-Reactive Protein