title: Ewing sarcoma with 7;22 translocation: three new cases and clinicopathological characterization.
abstract: Ewing sarcoma (ES) is the second most common primary bone malignancy in children and is typically characterized by a translocation involving the EWS gene on chromosome 22 and a member of the ETS family of genes: FLI1 (90%), ERG1 (5%), ETV1 (1%), ETV4 (1%), and FEV (1%). We identified three new cases of t(7;22) (p22;q12) (EWS-ETV1) ES and a literature search revealed an additional six cases. In comparison to conventional ES with t(11;22) (q24;q12) (EWS-FLI1), the t(7;22) ES variant has a higher propensity for females and children in a younger age group and it occurs more commonly in extraosseous locations.
authors.affiliation: Department of Pathology, Children's Healthcare of Atlanta, Atlanta, Georgia 30322, USA.
authors.forename: Sarah Catherine
authors.initials: SC
authors.lastname: Shulman
authors.forename: Howard
authors.initials: H
authors.lastname: Katzenstein
authors.forename: Julia
authors.initials: J
authors.lastname: Bridge
authors.forename: Lucas L
authors.initials: LL
authors.lastname: Bannister
authors.forename: Muna
authors.initials: M
authors.lastname: Qayed
authors.forename: Shervin
authors.initials: S
authors.lastname: Oskouei
authors.forename: Bahig M
authors.initials: BM
authors.lastname: Shehata
mesh_terms: D059786:Abnormal Karyotype; D014408:Biomarkers, Tumor / Q000378:metabolism; D001859:Bone Neoplasms / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D002648:Child; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics*; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics*; D003131:Combined Modality Therapy; D004273:DNA, Neoplasm / Q000032:analysis; D018572:Disease-Free Survival; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D015514:Oncogene Proteins, Fusion / Q000235:genetics / Q000378:metabolism; D012512:Sarcoma, Ewing / Q000235:genetics* / Q000473:pathology / Q000628:therapy; D014178:Translocation, Genetic
chemical_list: D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm; C122140:EWS-ETV1 fusion protein, human; D015514:Oncogene Proteins, Fusion