title: Tec family kinases in inflammation and disease.
abstract: Over the last decade, the Tec family of nonreceptor tyrosine kinases (Btk, Tec, Bmx, Itk, and Rlk) have been shown to play a key role in inflammation and bone destruction. Bruton's tyrosine kinase (Btk) has been the most widely studied due to the critical role of this kinase in B-cell development and recent evidence showing that blocking Btk signaling is effective in ameliorating lymphoma progression and experimental arthritis. This review will examine the role of TFK in myeloid cell function and the potential of targeting these kinases as a therapeutic intervention in autoimmune disorders such as rheumatoid arthritis.
authors.affiliation: Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Kennedy Institute of Rheumatology, University of Oxford, London, UK. nicole.horwood@kennedy.ox.ac.uk
authors.forename: Nicole J
authors.initials: NJ
authors.lastname: Horwood
authors.forename: Ania M
authors.initials: AM
authors.lastname: Urbaniak
authors.forename: Lynett
authors.initials: L
authors.lastname: Danks
mesh_terms: D000818:Animals; D001172:Arthritis, Rheumatoid / Q000188:drug therapy / Q000378:metabolism*; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D051379:Mice; D022423:Myeloid Cells / Q000166:cytology / Q000378:metabolism*; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors* / Q000145:classification / Q000378:metabolism
chemical_list: D004791:Enzyme Inhibitors; C089848:Tec protein-tyrosine kinase; D011505:Protein-Tyrosine Kinases