title: Structure-function relationships between spectral-domain OCT and standard achromatic perimetry.
abstract: OBJECTIVE
  To explore structure-function relationships in early glaucoma with spectral-domain optical coherence tomography (SD-OCT) and standard achromatic perimetry.
  
  
  METHODS
  One hundred thirty-six eyes of 97 patients with suspected or early glaucoma were enrolled from the clinical database at UCLA's Glaucoma Division. All patients had good-quality peripapillary retinal nerve fiber layer (RNFL)/optic disc measurements and a reliable 24-2 SITA-Standard Humphrey visual field (VF) within a 6-month period. Correlations of global and sectoral RNFL thickness and rim area (RA) measurements, with corresponding global and regional VF sensitivities (both in logarithmic [dB] and 1/Lambert scales [1/L]), were investigated with components of variance models.
  
  
  RESULTS
  The average RNFL thickness, RA, and mean deviation (MD) were 85.6 ± 5.7 μ, 1.0 ± 0.3 mm(2), and -1.3 ± 1.9 dB, respectively. Global RA demonstrated a stronger correlation with MD compared to average RNFL thickness (P = 0.002). The highest correlations were observed between superonasal VF cluster (in dB scale) and inferotemporal RA (R(2) = 0.26, 95% CI: 0.15-0.40) or inferotemporal RNFL thickness (R(2) = 0.24, 95% CI: 0.13-0.37). In glaucoma suspects, the highest correlations were seen between superonasal VF cluster and inferotemporal RA (R(2) = 0.16) in dB scale or RNFL thickness (R(2) = 0.10) in 1/L scale. Correlations were slightly greater with dB scale than 1/L scale and tended to be linear with both scales.
  
  
  CONCLUSIONS
  Structure-function relationships can be detected in early glaucoma with SD-OCT. Correlations of RA with VF thresholds tended to be higher compared to those of RNFL. Structure-function relationships were well described with a linear model.
authors.affiliation: Glaucoma Division, Jules Stein Eye Institute, UCLA, Los Angeles, California 90095, USA.
authors.forename: Naveed
authors.initials: N
authors.lastname: Nilforushan
authors.forename: Nariman
authors.initials: N
authors.lastname: Nassiri
authors.forename: Sasan
authors.initials: S
authors.lastname: Moghimi
authors.forename: Simon K
authors.initials: SK
authors.lastname: Law
authors.forename: JoAnn
authors.initials: J
authors.lastname: Giaconi
authors.forename: Anne L
authors.initials: AL
authors.lastname: Coleman
authors.forename: Joseph
authors.initials: J
authors.lastname: Caprioli
authors.forename: Kouros
authors.initials: K
authors.lastname: Nouri-Mahdavi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D003430:Cross-Sectional Studies; D005260:Female; D005901:Glaucoma / Q000175:diagnosis / Q000503:physiopathology*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D009798:Ocular Hypertension / Q000175:diagnosis / Q000503:physiopathology; D009901:Optic Nerve Diseases / Q000175:diagnosis / Q000503:physiopathology*; D012165:Retinal Ganglion Cells / Q000473:pathology*; D012189:Retrospective Studies; D041623:Tomography, Optical Coherence / Q000379:methods*; D014065:Tonometry, Ocular; D014786:Vision Disorders / Q000503:physiopathology; D058609:Visual Field Tests / Q000379:methods*; D014794:Visual Fields / Q000502:physiology*