title: Meta-analysis of the cystatin C(CST3) gene G73A polymorphism and susceptibility to Alzheimer's disease.
abstract: BACKGROUND
  The association between cystatin C(CST3) gene (rs1064039) G73A polymorphism and Alzheimer's disease (AD) is controversial. The objective of the study was to investigate the possible association between CST3 G73A polymorphism and AD.
  
  
  METHODS
  We performed a meta-analysis pooling data from all relevant studies including 2,410 cases and 2,539 controls. We applied a random-effects or fixed-effects model to combine odds ratio (OR) and 95% confidence intervals (95% CI).
  
  
  RESULTS
  Positive associations of the CST3 G73A polymorphism with AD risk were found in allele comparison A versus G (OR = 1.61, 95% CI = 1.19-2.18), dominant model AG + GG versus AA (OR = 0.63, 95% CI = 0.47-0.86), and homozygote comparison AA versus GG (OR = 1.61, 95% CI = 1.19-2.18). In subgroup analysis stratified by ethnicity, significant associations were also demonstrated in Caucasians under allele comparison (OR = 1.17, 95% CI = 1.02-1.33), dominant genetic (OR = 0.59, 95% CI = 0.40-0.86) model, and homozygote comparison (OR = 1.73, 95% CI = 1.18-2.54), but not in Asians. In subgroup analysis according to the age of onset, 73A allele (A versus G) was significantly associated with susceptibility to AD in Caucasians (OR = 1.26, 95% CI = 1.06-1.50), However, no association was found in Asians.
  
  
  CONCLUSIONS
  The CST3 G73A polymorphism is associated with AD in Caucasian populations, but not in Asians.
authors.affiliation: Department of Neurology, The Affiliated Wuxi Second Hospital, Nanjing Medical University, Wuxi, Jiangsu, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Hua
authors.forename: Hui
authors.initials: H
authors.lastname: Zhao
authors.forename: Xiaojie
authors.initials: X
authors.lastname: Lu
authors.forename: Yuenan
authors.initials: Y
authors.lastname: Kong
authors.forename: Huihan
authors.initials: H
authors.lastname: Jin
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D002681:China; D016001:Confidence Intervals; D055316:Cystatin C / Q000235:genetics*; D016206:Databases, Bibliographic / Q000706:statistics & numerical data; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008297:Male; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D055316:Cystatin C