title: From fracture risk prediction to evaluating fracture patterns: recent advances in the epidemiology of osteoporosis.
abstract: Understanding the factors associated with fracture is one of the main research objective of the osteoporosis epidemiology field. Tools such as FRAX have overall improved the ability of clinicians and researchers to identify individuals at high risk of fragility fractures. However, the performance of these tools in specific subpopulations needs further examination. We highlight recent studies that have shown under- or overestimation of fractures using FRAX in subpopulations, as well as recently proposed modifications to this important algorithm. We also discuss recent evaluations of secular trends in fracture incidence.
authors.affiliation: Department of Epidemiology, University of Alabama at Birmingham, 35294, USA. ncwright@uab.edu
authors.forename: Nicole C
authors.initials: NC
authors.lastname: Wright
authors.forename: Kenneth G
authors.initials: KG
authors.lastname: Saag
mesh_terms: D000465:Algorithms; D015519:Bone Density / Q000502:physiology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D004305:Dose-Response Relationship, Drug; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D010024:Osteoporosis / Q000453:epidemiology; D058866:Osteoporotic Fractures / Q000453:epidemiology / Q000209:etiology*; D018570:Risk Assessment / Q000379:methods
chemical_list: D005938:Glucocorticoids