title: Stronger association of common variants in TCF7L2 gene with nonobese type 2 diabetes in the Latvian population.
abstract: Polymorphisms in the gene coding for transcription factor 7 like 2 (TCF7L2) are recognized as the strongest common genetic risk factors for type 2 diabetes (T2D) across multiple ethnicities. This study was conducted to evaluate an association between TCF7L2 variants and diabetes susceptibility in the population of Latvia. We genotyped 4 single nucleotide polymorphisms (SNP) rs7901695, rs7903146, rs11196205 and rs12255372 in 1 093 controls and 1 043 diabetic subjects. Association with T2D was found for 3 SNPs rs7901695, rs7903146 and rs12255372 in the whole sample (under an additive genetic model, the adjusted odds ratios (OR) were 1.26, 95% CI [1.08-1.48], P=0.003; OR=1.32, 95% CI [1.12-1.55], P=0.001 and OR=1.35, 95% CI [1.15-1.60], P=0.0004 respectively). In addition observed effects on T2D susceptibility for analysed SNPs were higher among subjects with BMI under 30 kg/m². The impact of TCF7L2 variation on T2D risk in Latvian population is compatible with that demonstrated by a range of studies conducted in various ethnic groups.
authors.affiliation: Latvian Biomedical Research and Study Centre, Riga, Latvia.
authors.forename: I
authors.initials: I
authors.lastname: Kalnina
authors.forename: K
authors.initials: K
authors.lastname: Geldnere
authors.forename: L
authors.initials: L
authors.lastname: Tarasova
authors.forename: L
authors.initials: L
authors.lastname: Nikitina-Zake
authors.forename: R
authors.initials: R
authors.lastname: Peculis
authors.forename: D
authors.initials: D
authors.lastname: Fridmanis
authors.forename: V
authors.initials: V
authors.lastname: Pirags
authors.forename: J
authors.initials: J
authors.lastname: Klovins
mesh_terms: D015992:Body Mass Index; D016022:Case-Control Studies; D030541:Databases, Genetic; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000235:genetics* / Q000378:metabolism; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D007844:Latvia; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications; D020641:Polymorphism, Single Nucleotide; D058118:Transcription Factor 7-Like 2 Protein / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism
chemical_list: C544894:TCF7L2 protein, human; D058118:Transcription Factor 7-Like 2 Protein