title: Regulation of calcium sensing receptor trafficking by RAMPs.
abstract: As mentioned earlier in this book, RAMPs were identified as proteins escorting the Calcitonin Receptor-Like Receptor (CRLR) to the plasma membrane (PM) to generate either CGRP (when associated with RAMP1), or adrenomedullin receptors (when associated with RAMP2 or RAMP3). Some years after this initial discovery, it was established that RAMPs can accompany four additional class B G Protein-Coupled Receptors-GPCRs- (PTH1, PTH2, glucagon receptor and VPAC1) to the PM.(1) By demonstrating that the sorting traffic of the Calcium Sensing Receptor (CaSR), a class C GPCR, is positively modulated by RAMP1 and RAMP3,(2) our data extended the concept of RAMPs as escorting molecules to another class of GPCRs.
authors.affiliation: Institut de Génomique Fonctionnelle, INSERM U661-CNRS UMR5203, Montpellier, France.
authors.forename: Tristan
authors.initials: T
authors.lastname: Bouschet
authors.forename: Stéphane
authors.initials: S
authors.lastname: Martin
authors.forename: Jeremy M
authors.initials: JM
authors.lastname: Henley
mesh_terms: D000818:Animals; D002460:Cell Line; D006801:Humans; D021381:Protein Transport; D058261:Receptor Activity-Modifying Proteins / Q000502:physiology*; D044169:Receptors, Calcium-Sensing / Q000378:metabolism*
chemical_list: D058261:Receptor Activity-Modifying Proteins; D044169:Receptors, Calcium-Sensing