title: RAMP like proteins : RTP and REEP family of proteins.
abstract: Mammalian odorant receptors (ORs) are typically retained in the endoplasmic reticulum (ER) when expressed in heterologous cells. The RTP (Receptor-Transporting Protein) and REEP (Receptor Expression Enhancing Protein) family of proteins were first identified as partners for ORs, promoting cell-surface expression and leading to functional responses in heterologous cell systems. Like RAMPs, the RTP and REEP proteins appear to partner with GPCRs to promote cell-surface expression. Unlike RAMPs, they do not appear to alter the pharmacology of the partner receptor.
authors.affiliation: Department of Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC, USA.
authors.forename: Joel
authors.initials: J
authors.lastname: Mainland
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Matsunami
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008969:Molecular Sequence Data; D018035:Receptors, Odorant / Q000737:chemistry / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid
chemical_list: D018035:Receptors, Odorant