title: Balloon-expandable stent placement in patients with immediate reocclusion after initial successful thrombolysis of acute middle cerebral arterial obstruction.
abstract: We present the results of our approach for treating 12 consecutive cases of acute middle cerebral artery (MCA) stroke by performing balloon-expandable stent (BES) placement after immediate reocclusion due to the underlying stenosis after intra-arterial thrombolysis (IAT).  We retrospectively reviewed the clinical outcomes of 12 patients with acute MCA stroke who underwent recanalization by BES placement in an underlying stenosis after IAT. The time to treatment, urokinase dose, duration of the procedure, recanalization rates and symptomatic hemorrhage were analyzed. Clinical outcome measures were assessed on admission and at discharge (the National Institutes of Health stroke scores [NIHSS]) as well as three months after treatment (modified Rankin scales [mRS]).  The median NIHSS score on admission was 8.6. Four patients received IV rtPA. The median time from symptom onset to IAT was 236 minutes and the median duration of IAT was 62 minutes. The median dose of urokinase was 140,000 units. Initial recanalization after stent deployment (thrombolysis in cerebral ischemia attack grade of II or III) was achieved in all patients. Two patients died in the hospital due to aspiration pneumonia during medical management. In two patients, in-stent reocclusion occurred within 48 hours after stent deployment. At discharge, the median NIHSS score in ten patients (including the patients with reobstruction) was 2.4. The three-month outcome was excellent (mRS, 0-1) in eight patients.  In this study, BES deployment was safe and effective in patients with an immediately reoccluded MCA after successful IAT.
authors.affiliation: Department of Radiology, Chonbuk National University Medical School and Hospital, Jeonju, Jeonbuk, Korea.
authors.forename: H K
authors.initials: HK
authors.lastname: Lee
authors.forename: H S
authors.initials: HS
authors.lastname: Kwak
authors.forename: G H
authors.initials: GH
authors.lastname: Chung
authors.forename: S B
authors.initials: SB
authors.lastname: Hwang
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000800:Angioplasty, Balloon / Q000379:methods; D002548:Cerebral Revascularization / Q000379:methods* / Q000401:mortality; D003131:Combined Modality Therapy; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D011859:Radiography; D012189:Retrospective Studies; D055502:Secondary Prevention; D015607:Stents; D014568:Urokinase-Type Plasminogen Activator / Q000627:therapeutic use*
chemical_list: D005343:Fibrinolytic Agents; D014568:Urokinase-Type Plasminogen Activator