title: [Lipid peroxidation in different tissues of rats treated with 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine].
abstract: OBJECTIVE
  To study the effects of 2-amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine (PhIP) (a kind of heterocyclic amines) on lipid peroxidation in the heart, lung, liver and kidney of rats.
  
  
  METHODS
  Rats were divided into a normal control group and three PhIP groups exposed to different doses of PhIP (5, 10 and 15 mg/kg body weight) by gavage. The indexes of lipid peroxidation were measured 24 hours after gavaging.
  
  
  RESULTS
  In comparison with the control group, the activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) were increased in hearts and lungs while were significantly inhibited in livers of rats in PhIP groups at the doses of 10 and 15 mg/kg body weight (P < 0.05 or P < 0.01). There was no significant change in kidneys. Moreover, malondialdehyde (MDA) levels in the tissues of rats increased with a dose-dependent manner for PhIP exposure.
  
  
  CONCLUSIONS
  PhIP could cause lipid peroxidation in the heart, lung, liver and kidney of rats, and such effects were varied in different organs.
authors.affiliation: Research Center of Environmental Science and Engineering, Shanxi University, Taiyuan 030006, China. lirj@sxu.edu.cn
authors.forename: Ruijin
authors.initials: R
authors.lastname: Li
authors.forename: Wanqing
authors.initials: W
authors.lastname: Li
authors.forename: Jingfang
authors.initials: J
authors.lastname: Xie
authors.forename: Yuexia
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000818:Animals; D002374:Catalase / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D006321:Heart / Q000187:drug effects; D007093:Imidazoles / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008168:Lung / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D007093:Imidazoles; C049584:2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase