title: Asymmetric Michael addition of N-boc-protected oxindoles to nitroalkenes catalyzed by a chiral secondary amine.
abstract: New mission for prolinol ethers: A secondary-amine-catalyzed Michael addition of N-Boc-protected oxindoles to nitroalkenes through a Brønsted base activation mode has been developed, furnishing the products in excellent yields (88-98 %), diastereoselectivities (d.r.=98:2->99:1) and high to excellent enantioselectivities (82->99 % ee; see scheme).
authors.affiliation: Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52074 Aachen, Germany.
authors.forename: Chuan
authors.initials: C
authors.lastname: Wang
authors.forename: Xuena
authors.initials: X
authors.lastname: Yang
authors.forename: Dieter
authors.initials: D
authors.lastname: Enders