title: Lack of interaction between sertraline and lamotrigine in psychiatric patients: a retrospective study.
abstract: BACKGROUND
  This study evaluates the pharmacokinetic interaction between sertraline and lamotrigine in psychiatric patients.
  
  
  METHODS
  We identifi ed patients with at least 1 measurement of trough lamotrigine plasma concentration (at steady-state) during lamotrigine therapy and compared dose and plasma concentrations between patients who received lamotrigine with sertraline and patients who received lamotrigine without sertraline.
  
  
  RESULTS
  The dose corrected concentration of lamotrigine in patients receiving lamotrigine in combination with sertraline was 60.4 μmol/L × 1,000/mg/day (SD: 31.1) (N = 7) compared to 51.1 μmol/L × 1 000/mg/day (SD: 27.6) (N = 44) in patients using lamotrigine without sertraline (p = 0.42).
  
  
  CONCLUSIONS
  The slightly slower metabolism of lamotrigine in patients receiving lamotrigine with sertraline compared with those receiving lamotrigine alone is not believed to be of clinical signifi cance. However, due to the limited power, we may have overlooked a diff erence that could be clinically relevant.
authors.affiliation: Department of Neurology, Aarhus University Hospital, Aarhus, Denmark. Jakob@farm.au.dk
authors.forename: J
authors.initials: J
authors.lastname: Christensen
authors.forename: A P
authors.initials: AP
authors.lastname: Sandgaard
authors.forename: P
authors.initials: P
authors.lastname: Sidenius
authors.forename: K
authors.initials: K
authors.lastname: Linnet
authors.forename: R W
authors.initials: RW
authors.lastname: Licht
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D001714:Bipolar Disorder / Q000188:drug therapy*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D000077213:Lamotrigine; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D020280:Sertraline / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D014227:Triazines / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D000927:Anticonvulsants; D000928:Antidepressive Agents; D014227:Triazines; D020280:Sertraline; D000077213:Lamotrigine