title: Rice APC/C(TE) controls tillering by mediating the degradation of MONOCULM 1.
abstract: Rice MONOCULM 1 (MOC1) and its orthologues LS/LAS (lateral suppressor in tomato and Arabidopsis) are key promoting factors of shoot branching and tillering in higher plants. However, the molecular mechanisms regulating MOC1/LS/LAS have remained elusive. Here we show that the rice tiller enhancer (te) mutant displays a drastically increased tiller number. We demonstrate that TE encodes a rice homologue of Cdh1, and that TE acts as an activator of the anaphase promoting complex/cyclosome (APC/C) complex. We show that TE coexpresses with MOC1 in the axil of leaves, where the APC/C(TE) complex mediates the degradation of MOC1 by the ubiquitin-26S proteasome pathway, and consequently downregulates the expression of the meristem identity gene Oryza sativa homeobox 1, thus repressing axillary meristem initiation and formation. We conclude that besides having a conserved role in regulating cell cycle, APC/C(TE) has a unique function in regulating the plant-specific postembryonic shoot branching and tillering, which are major determinants of plant architecture and grain yield.
authors.affiliation: National Key Facility for Crop Gene Resources and Genetic Improvement, Institute of Crop Science, Chinese Academy of Agricultural Sciences, Beijing 100081, China.
authors.forename: Qibing
authors.initials: Q
authors.lastname: Lin
authors.forename: Dan
authors.initials: D
authors.lastname: Wang
authors.forename: Hui
authors.initials: H
authors.lastname: Dong
authors.forename: Suhai
authors.initials: S
authors.lastname: Gu
authors.forename: Zhijun
authors.initials: Z
authors.lastname: Cheng
authors.forename: Jie
authors.initials: J
authors.lastname: Gong
authors.forename: Ruizhen
authors.initials: R
authors.lastname: Qin
authors.forename: Ling
authors.initials: L
authors.lastname: Jiang
authors.forename: Gang
authors.initials: G
authors.lastname: Li
authors.forename: Jiu Lin
authors.initials: JL
authors.lastname: Wang
authors.forename: Fuqing
authors.initials: F
authors.lastname: Wu
authors.forename: Xiuping
authors.initials: X
authors.lastname: Guo
authors.forename: Xin
authors.initials: X
authors.lastname: Zhang
authors.forename: Cailin
authors.initials: C
authors.lastname: Lei
authors.forename: Haiyang
authors.initials: H
authors.lastname: Wang
authors.forename: Jianmin
authors.initials: J
authors.lastname: Wan
mesh_terms: D064173:Anaphase-Promoting Complex-Cyclosome; D017360:Arabidopsis / Q000235:genetics / Q000378:metabolism; D059447:Cell Cycle Checkpoints / Q000235:genetics; D018797:Cell Cycle Proteins / Q000235:genetics* / Q000378:metabolism*; D002455:Cell Division / Q000235:genetics; D018506:Gene Expression Regulation, Plant; D018398:Homeodomain Proteins / Q000096:biosynthesis / Q000235:genetics; D018519:Meristem / Q000235:genetics / Q000254:growth & development / Q000378:metabolism; D009154:Mutation; D012275:Oryza / Q000235:genetics* / Q000254:growth & development / Q000378:metabolism*; D010940:Plant Proteins / Q000096:biosynthesis / Q000235:genetics* / Q000378:metabolism*; D018520:Plant Shoots / Q000235:genetics / Q000378:metabolism; D046988:Proteasome Endopeptidase Complex / Q000378:metabolism; D012568:Schizosaccharomyces / Q000235:genetics / Q000378:metabolism; D015534:Trans-Activators / Q000096:biosynthesis / Q000235:genetics; D043743:Ubiquitin-Protein Ligase Complexes / Q000378:metabolism*
chemical_list: D018797:Cell Cycle Proteins; D018398:Homeodomain Proteins; C099194:OSH1 protein, Oryza sativa; D010940:Plant Proteins; D015534:Trans-Activators; D043743:Ubiquitin-Protein Ligase Complexes; D064173:Anaphase-Promoting Complex-Cyclosome; D046988:Proteasome Endopeptidase Complex; C061553:ATP dependent 26S protease