title: [Characteristics of pregnancy and delivery of fetuses affected by either central nervous system malformations or chromosomal abnormalities].
abstract: OBJECTIVE
  To determine whether fetuses affected by either chromosomal abnormalities or central nervous system (CNS) malformations are prone to complications during pregnancy and delivery.
  
  
  METHODS
  In this study, 320 singleton pregnancies with CNS malformations and 133 singleton pregnancies with chromosomal abnormaLities were compared with 149,112 singleton births without any known congenital anomalies. Exclusion criteria were: births with other congenital anomalies or malformations, pregnancies Lacking prenatal care and multiple pregnancies. Data was obtained using the computerized birth discharge records. The statistical analysis was performed with the SPSS package.
  
  
  RESULTS
  There were no statistically significant differences in maternal age, ethnicity, uterine anomalies or parity. The ratio of general anesthesia was almost double in the study groups compared to the control group: 25% in the CNS malformation group (RR 2.617, CI 2.031-3.372) and 25.6% in the chromosomal abnormality group (RR 2.696, CI 1.825-3.982) and 11.3% in the control group (p < 0.001). There were nearly double cesarean sections (CS) rates in both study groups: 21.5% in the CNS malformation group, 20.3% in the chromosomal abnormaLity group and 12% in the control group. A logistic regression model that included previous CS, maLpresentation, non-reassuring fetal heart monitor (NRFHR) and presence of a malformation, concluded that the presence of a malformation was not an independent risk factor for CS. However, indirect causes, such as malpresentation (4.34 OR), were independently associated with the malformations.
  
  
  CONCLUSIONS
  Fetuses affected by either CNS malformations or chromosomal abnormalities have a higher rate of pregnancy and delivery complications, including those which increase the risk of maternal morbidity and mortality.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Health Sciences, Soroka University Medical Center, Ben-Gurion University of the Negev, Beer Sheva, Israel.
authors.forename: Jordana Mashiach
authors.initials: JM
authors.lastname: Friedler
authors.forename: Moshe
authors.initials: M
authors.lastname: Mazor
authors.forename: Ilana
authors.initials: I
authors.lastname: Shoham-Vardi
authors.forename: Asher
authors.initials: A
authors.lastname: Bashiri
mesh_terms: D000328:Adult; D000768:Anesthesia, General / Q000706:statistics & numerical data; D002585:Cesarean Section / Q000706:statistics & numerical data; D025063:Chromosome Disorders / Q000453:epidemiology; D000013:Congenital Abnormalities / Q000453:epidemiology*; D036861:Delivery, Obstetric / Q000379:methods*; D005260:Female; D006801:Humans; D016015:Logistic Models; D009421:Nervous System Malformations / Q000453:epidemiology; D007744:Obstetric Labor Complications / Q000453:epidemiology* / Q000209:etiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology* / Q000209:etiology; D011256:Pregnancy Outcome; D012307:Risk Factors; D055815:Young Adult