title: Pathogenic and regulatory roles for B cells in experimental autoimmune encephalomyelitis.
abstract: A dual role of B cells in experimental autoimmune encephalomyelitis (EAE), the animal model of the human autoimmune disease multiple sclerosis (MS), has been established. In the first role, B cells contribute to the pathogenesis of EAE through the production of anti-myelin antibodies that contribute to demyelination. On the contrary, B cells have also been shown to have protective functions in that they play an essential role in the spontaneous recovery from EAE. In this review, we summarize studies conducted in a number of species demonstrating the conditions under which B cells are pathogenic in EAE. We also discuss the phenotype and anti-inflammatory mechanisms of regulatory B cells.
authors.affiliation: Blood Research Institute, BloodCenter of Wisconsin, Milwaukee, Wisconsin 53201-2178, USA.
authors.forename: Monica K
authors.initials: MK
authors.lastname: Mann
authors.forename: Avijit
authors.initials: A
authors.lastname: Ray
authors.forename: Sreemanti
authors.initials: S
authors.lastname: Basu
authors.forename: Christopher L
authors.initials: CL
authors.lastname: Karp
authors.forename: Bonnie N
authors.initials: BN
authors.lastname: Dittel
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology; D016175:B-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism; D001402:B-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D060151:B-Lymphocytes, Regulatory / Q000276:immunology / Q000378:metabolism; D016207:Cytokines / Q000096:biosynthesis / Q000276:immunology; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000209:etiology / Q000276:immunology*; D006801:Humans; D007136:Immunoglobulins / Q000276:immunology
chemical_list: D000906:Antibodies; D016207:Cytokines; D007136:Immunoglobulins