title: Progression of cataracts following photodynamic therapy combined with intravitreous triamcinolone injection in cases of age-related macular degeneration.
abstract: BACKGROUND
  To present long-term data on the progression of cataracts following photodynamic therapy (PDT) combined with 4 mg intravitreal triamcinolone acetonide (IVTA) for age-related macular degeneration (AMD).
  
  
  METHODS
  Fifty-seven phakic eyes of 56 patients underwent the treatment between October 2004 and November 2006. The follow-up period ranged from 12 to 38 months with 3 months interval of observation and repeated treatment at recurrence.
  
  
  RESULTS
  Cataract progression was noted in 40 eyes 5-21 months after treatment, consisting of 4 eyes between 3 and < 6 months after treatment, 22 eyes between 6 and < 12 months, 8 eyes between 12 and < 18 months, and 6 eyes between 18 and < 24 months. The percentage of the eyes with cataract progression began to decrease 5 months after treatment and, occurred most frequently during the period from 6 months to 12 months after treatment. There was no significant difference in age, follow-up period, or the frequency of the treatment between the cataract progression group and the non progression group. Twenty four eyes underwent surgery 10-31 months after treatment, showing significant improvement in visual acuity.
  
  
  CONCLUSIONS
  This study showed high incidence of cataract during a long-term follow-up after PDT combined with IVTA and significant reduction of visual acuity due to cataract.
authors.affiliation: Department of Ophthalmology and Visual Sciences, Osaka City University, Graduate School of Medicine, Japan. iwami-oss@umin.ac.jp
authors.forename: Hisashi
authors.initials: H
authors.lastname: Iwami
authors.forename: Takeya
authors.initials: T
authors.lastname: Kohno
authors.forename: Manabu
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Mayumi
authors.initials: M
authors.lastname: Kaida
authors.forename: Norito
authors.initials: N
authors.lastname: Miki
authors.forename: Shinsuke
authors.initials: S
authors.lastname: Ataka
authors.forename: Kunihiko
authors.initials: K
authors.lastname: Shiraki
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002386:Cataract / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D002387:Cataract Extraction; D018450:Disease Progression; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage* / Q000009:adverse effects*; D006801:Humans; D058449:Intravitreal Injections; D008268:Macular Degeneration / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy / Q000009:adverse effects*; D012189:Retrospective Studies; D013997:Time Factors; D016896:Treatment Outcome; D014221:Triamcinolone / Q000008:administration & dosage* / Q000009:adverse effects*; D014792:Visual Acuity / Q000187:drug effects
chemical_list: D005938:Glucocorticoids; D014221:Triamcinolone