title: Triterpene glycosides from Astragalus angustifolius.
abstract: Six new cycloartane-type (1- 6) and four new oleanane-type (7- 10) triterpene glycosides were isolated from Astragalus angustifolius Lam., together with five known triterpene glycosides. Their structures were established by the extensive use of 1D and 2D-NMR experiments along with ESIMS and HRMS analysis. Compounds 1- 3 are glycosides of cycloastragenol, while compounds 4- 6 show the C-24 epimer of cycloastragenol as aglycone, encountered for the first time in nature. All compounds were evaluated for their antiproliferative activity in Hela, H-446, HT-29, and U937 cell lines. Only compound 8 displayed a weak activity with IC (50) values of 36 and 50 µM against Hela and HT-29 cell lines, respectively.
authors.affiliation: Department of Chemistry, Faculty of Science, Ege University, Bornova, Izmir, Turkey.
authors.forename: Derya
authors.initials: D
authors.lastname: Gülcemal
authors.forename: Milena
authors.initials: M
authors.lastname: Masullo
authors.forename: Erdal
authors.initials: E
authors.lastname: Bedir
authors.forename: Michela
authors.initials: M
authors.lastname: Festa
authors.forename: Tamer
authors.initials: T
authors.lastname: Karayıldırım
authors.forename: Ozgen
authors.initials: O
authors.lastname: Alankus-Caliskan
authors.forename: Sonia
authors.initials: S
authors.lastname: Piacente
mesh_terms: D027883:Astragalus Plant / Q000737:chemistry*; D049109:Cell Proliferation / Q000187:drug effects; D054697:Cytostatic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019073:HT29 Cells; D006367:HeLa Cells; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D014421:Turkey; D020298:U937 Cells
chemical_list: D054697:Cytostatic Agents; D006027:Glycosides; D010936:Plant Extracts; D014315:Triterpenes