title: Functional imaging techniques in hepatocellular carcinoma.
abstract: Novel biological therapies, including tyrosine kinase inhibitors such as sorafenib, improve the survival of patients with unresectable hepatocellular carcinoma. However, assessment of therapeutic efficacy remains challenging with conventional imaging techniques such as ultrasonography, CT or MRI that predominantly rely on size change to detect a treatment response. A beneficial tumour effect may go unrecognized in some patients who do not show tumour shrinkage and conversely, some patients may be maintained on treatment that is not active. This paper explores the use of functional imaging methods that are showing promise in the assessment of hepatocellular carcinoma.
authors.affiliation: Division of Imaging Sciences and Biomedical Engineering, Kings College London, London, UK.
authors.forename: V
authors.initials: V
authors.lastname: Goh
authors.forename: D
authors.initials: D
authors.lastname: Sarker
authors.forename: S
authors.initials: S
authors.lastname: Osmany
authors.forename: G J R
authors.initials: GJ
authors.lastname: Cook
mesh_terms: D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000098:blood supply / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000628:therapy; D003952:Diagnostic Imaging / Q000379:methods*; D006801:Humans; D008113:Liver Neoplasms / Q000098:blood supply / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000628:therapy; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging; D011859:Radiography; D011877:Radionuclide Imaging; D014463:Ultrasonography