title: Response-adaptive designs for continuous treatment responses in phase III clinical trials: A review.
abstract: A variety of response-adaptive randomization procedures have been proposed in literature assuming binary outcomes. However, the list is not so long for continuous outcomes though many real clinical trials deal with continuous treatment responses. In this paper, we attempt to explore the available procedures together with a comparison of their performances. Some real-life adaptive trial is also reviewed.
authors.affiliation: Applied Statistics Unit, Indian Statistical Institute, Kolkata, India atanu@isical.ac.in.
authors.forename: Atanu
authors.initials: A
authors.lastname: Biswas
authors.affiliation: Department of Statistics, West Bengal State University, Kolkata, India.
authors.forename: Rahul
authors.initials: R
authors.lastname: Bhattacharya
mesh_terms: D056808:Biostatistics; D017326:Clinical Trials, Phase III as Topic / Q000706:statistics & numerical data*; D003198:Computer Simulation; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy / Q000635:transmission; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control; D015233:Models, Statistical; D051474:Neuralgia, Postherpetic / Q000188:drug therapy; D000069583:Pregabalin / Q000627:therapeutic use; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy; D016032:Randomized Controlled Trials as Topic / Q000706:statistics & numerical data*; D018709:Statistics, Nonparametric; D015215:Zidovudine / Q000627:therapeutic use
chemical_list: D015215:Zidovudine; D000069583:Pregabalin