title: JPEG2000 compression of CT images used for measuring coronary artery calcification score: assessment of optimal compression threshold.
abstract: OBJECTIVE
  The purpose of our study was to assess the acceptable compression threshold for JPEG2000 compression of CT images used for measuring coronary artery calcification scores (CACS) in terms of variability.
  
  
  METHODS
  In a retrospective review, 80 patients who had undergone CT for determination of the CACS were compiled in four subsets (20 scans each) according to CACS: 0, subset A; > 0 to ≥ 100, subset B; > 100 to ≤ 400, subset C; and > 400, subset D. Each scan was compressed using eight compression ratios (CRs). We measured the CACS on all 720 CT scans (80 original and 640 compressed scans). For each compressed scan, the variability in CACS was evaluated by comparing with the CACS of the corresponding original CT scan.
  
  
  RESULTS
  For each subset and each CR, we determined whether the upper limit of the one-sided 95% CI of the variability in CACS exceeded 5%. The variability in CACS tended to increase as the CR increased and tended to decrease in the order of increasing CACSs at each CR (i.e., subset B > subset C > subset D). With 5% as the limit of variability, acceptable compression CRs were between 20:1 and 25:1 for subset B; between 40:1 and 60:1 for subset C; and > 100:1 for subset D.
  
  
  CONCLUSIONS
  A level of 20:1 could be a potentially acceptable threshold for JPEG2000 compression of CT images used for measuring CACS, with 5% of the variability in CACS as the acceptable limit of variability.
authors.affiliation: Medical Information Center, Seoul National University Bundang Hospital, Gyeonggi-do, Korea.
authors.forename: Tae Ki
authors.initials: TK
authors.lastname: Kim
authors.forename: Kil Joong
authors.initials: KJ
authors.lastname: Kim
authors.forename: Sang Il
authors.initials: SI
authors.lastname: Choi
authors.forename: Kyoung Ho
authors.initials: KH
authors.lastname: Lee
authors.forename: Suyoung
authors.initials: S
authors.lastname: Kim
authors.forename: Jae Hwa
authors.initials: JH
authors.lastname: Cho
authors.forename: Jong Hoar
authors.initials: JH
authors.lastname: Yoon
mesh_terms: D002114:Calcinosis / Q000000981:diagnostic imaging*; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging*; D044962:Data Compression / Q000592:standards*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011857:Radiographic Image Interpretation, Computer-Assisted / Q000379:methods*; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed