title: [Clinicopathologic features and prognostic factors of gastric gastrointestinal stromal tumor with synchronous gastric cancer].
abstract: OBJECTIVE
  To evaluated the clinicopathologic features and prognostic factors of gastric gastrointestinal stromal tumor(GIST) with synchronous gastric cancer.
  
  
  METHODS
  The clinicopathologic records of 122 patients with gastric GIST who underwent surgical treatment from April 2000 to June 2010 were analyzed retrospectively. Twenty-six patients presented synchronous gastric cancer(group A), while 96 patients did not(group B). The clinicopathologic features of gastric GIST were compared between the two groups. Potential prognostic factors were evaluated by univariate and multivariate analyses.
  
  
  RESULTS
  Gastric GIST in group A were associated with smaller tumor diameter (P<0.01), lower mitotic count(P<0.05), lower Fletcher classification(P<0.01), and lower rate of pre-operative diagnosis(23.1% vs. 97.9%, P<0.01). On univariate analysis, maximum tumor diameter (P<0.01), mitotic count (P<0.01), Fletcher classification (P<0.01) and synchronous gastric cancer(P<0.05) were the predictive factors of survival. Multivariate analysis showed that Fletcher classification(P<0.05) and synchronous gastric cancer (P<0.01) were independent prognostic factors.
  
  
  CONCLUSIONS
  In patients with synchronous gastric GIST and gastric cancer, Fletcher classification of GIST is usually very low or low invasion risk and has minimal impact on the prognosis. Survival depends primarily on the gastric cancer.
authors.affiliation: Department of Gastric Surgery, Fujian Medical University Union Hospital, Fuzhou 350001, China.
authors.forename: Xiu-li
authors.initials: XL
authors.lastname: Liu
authors.forename: Jia-bin
authors.initials: JB
authors.lastname: Wang
authors.forename: Chang-ming
authors.initials: CM
authors.lastname: Huang
authors.forename: Chao-hui
authors.initials: CH
authors.lastname: Zheng
authors.forename: Ping
authors.initials: P
authors.lastname: Li
authors.forename: Jian-wei
authors.initials: JW
authors.lastname: Xie
authors.forename: Jian-xian
authors.initials: JX
authors.lastname: Lin
mesh_terms: D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000473:pathology* / Q000601:surgery