title: Cross-species ChIP-seq studies provide insights into regulatory strategies of PPARγ in adipocytes.
abstract: Three recent studies have investigated interspecies retention of binding sites of peroxisome proliferator-activated receptor γ (PPARγ), the master regulator of adipocyte differention, between mouse and human adipocytes. Here we discuss the major findings and demonstrate that retention of binding events is highly context-dependent.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark.
authors.forename: Søren F
authors.initials: SF
authors.lastname: Schmidt
authors.forename: Mette
authors.initials: M
authors.lastname: Jørgensen
authors.forename: Albin
authors.initials: A
authors.lastname: Sandelin
authors.forename: Susanne
authors.initials: S
authors.lastname: Mandrup
mesh_terms: D041721:3T3-L1 Cells; D017667:Adipocytes / Q000378:metabolism*; D000818:Animals; D001665:Binding Sites; D022762:CCAAT-Enhancer-Binding Proteins / Q000378:metabolism; D047369:Chromatin Immunoprecipitation; D006657:Histones / Q000378:metabolism; D006801:Humans; D051379:Mice; D047495:PPAR gamma / Q000378:metabolism*; D011485:Protein Binding
chemical_list: D022762:CCAAT-Enhancer-Binding Proteins; D006657:Histones; D047495:PPAR gamma