title: Effects of afobazole on cognitive behavior of the offspring of rats exposed to tobacco smoke during gestation period.
abstract: Experiments on the model of foraging behavior formation under conditions of free choice (T-maze) revealed learning failure against the background of reduced motor activity in the offspring of rats exposed to tobacco smoke on gestation days 1-20. Afobazole administered to pregnant rats orally in doses of 1 or 10 mg/kg daily during the whole gestation and/or entering rat pup body with breast milk from mothers receiving 200 mg/kg to day 20 of their life normalized their learning capacity. The formation of short-term and long-term memory in animals receiving afobazole did not differ from the control. Hence, afobazole corrects cognitive disorders in rats exposed to tobacco smoke during prenatal development.
authors.affiliation: V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia. olga_shreder@list.ru.
authors.forename: O V
authors.initials: OV
authors.lastname: Shreder
authors.forename: A S
authors.initials: AS
authors.lastname: Solomina
authors.forename: I B
authors.initials: IB
authors.lastname: Tsorin
authors.forename: S S
authors.initials: SS
authors.lastname: Trofimov
authors.forename: A D
authors.initials: AD
authors.lastname: Durnev
authors.forename: S B
authors.initials: SB
authors.lastname: Seredenin
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000831:Animals, Newborn; D014151:Anti-Anxiety Agents / Q000008:administration & dosage*; D001522:Behavior, Animal / Q000187:drug effects*; D001562:Benzimidazoles / Q000008:administration & dosage*; D003071:Cognition / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D057567:Memory, Long-Term / Q000187:drug effects; D008570:Memory, Short-Term / Q000187:drug effects; D009025:Morpholines / Q000008:administration & dosage*; D009043:Motor Activity / Q000187:drug effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000503:physiopathology / Q000517:prevention & control*; D051381:Rats; D012906:Smoke / Q000009:adverse effects
chemical_list: C410924:2-((2-morpholino)ethylthio)-5-ethoxybenzimidazole; D014151:Anti-Anxiety Agents; D001562:Benzimidazoles; D009025:Morpholines; D012906:Smoke