title: Influence of vitamin D supplementation on plasma lipid profiles: a meta-analysis of randomized controlled trials.
abstract: Observational studies have shown that low serum levels of vitamin D have been associated with an atherogenic lipid profile. However, the intervention studies gave divergent results. We conducted a meta-analysis of randomized controlled trials that evaluated the effects of vitamin D supplementation on blood lipids. A systematic literature search was conducted via MEDLINE, Cochrane library, and EMBASE for randomized controlled clinical trials assessing the effects of vitamin D supplementation on lipids. The mean change in total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG) from baseline was treated as a continuous variable. In all, 12 clinical trials consisting of 1346 participants were included in the analysis. The pooled estimate of effect for vitamin D supplementation on LDL-C was 3.23 mg/dl (95% confidence interval, 0.55 to 5.90 mg/dl). No statistically significant effects for vitamin D supplementation were observed for TC, HDL-C and TG (differences in means were 1.52 mg/dl (-1.42 to 4.46 mg/dl), -0.14 mg/dl (-0.99 to 0.71 mg/dl) and -1.92 mg/dl (-7.72 to 3.88 mg/dl) respectively). The lipid modulating effects of vitamin D supplementation should be further investigated though large-scale, randomized trials with adequate doses which can effectively elevated the active form of vitamin D in plasma and with proper population which has hyperlipemia as an inclusion criterion.
authors.affiliation: Department of Cardiology, the Second Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
authors.forename: Hao
authors.initials: H
authors.lastname: Wang
authors.forename: Ning
authors.initials: N
authors.lastname: Xia
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.forename: Dao-Quan
authors.initials: DQ
authors.lastname: Peng
mesh_terms: D050171:Dyslipidemias / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D000960:Hypolipidemic Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D008055:Lipids / Q000097:blood*; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome; D014807:Vitamin D / Q000493:pharmacokinetics / Q000627:therapeutic use*
chemical_list: D000960:Hypolipidemic Agents; D008055:Lipids; D014807:Vitamin D