title: Quality of life following liver transplantation in patients with liver metastases from colorectal carcinoma.
abstract: OBJECTIVE
  To study quality of life (QoL) in patients with liver metastases from colorectal carcinoma (CRC) following liver transplantation (Ltx).
  
  
  METHODS
  Ten patients participated in a prospective explorative pilot study. Inclusion criteria were nonresectable liver-only metastases determined by CT/MRI-, PET/CT- scans and colonoscopy, and ECOG 0-1. Primary outcome was QoL assessed by the EORTC-C30 questionnaires at baseline, and at 3, 6 and 12 months after Ltx.
  
  
  RESULTS
  The patients' age ranged from 50 to 63 years. Nine of 10 patients were observed for 12 months. One patient did not return the form at 6 months and died shortly after because of recurrence of the malignant disease. Compared to baseline, Ltx resulted in sustained excellent global health status scale (score of 100) in one patient, improved scores in 4 and unchanged scores in 3 patients at 12 months. The majority of the patients also reported good functional scores at follow-ups. Although two patients had marked symptoms both before and after Ltx, the patients in general reported low levels of pain and fatigue before and after surgery.
  
  
  CONCLUSIONS
  The present study indicates that CRC patients with liver-only metastases who receive Ltx have good QoL and have mostly minor symptoms the first year after Ltx.
authors.affiliation: Division of Cancer Medicine, Surgery and Transplant, Oslo University Hospital Rikshospitalet, Oslo, Norway. marit.andersen@ous-hf.no
authors.forename: Marit Helen
authors.initials: MH
authors.lastname: Andersen
authors.forename: Svein
authors.initials: S
authors.lastname: Dueland
authors.forename: Morten
authors.initials: M
authors.lastname: Hagness
authors.forename: Tone
authors.initials: T
authors.lastname: Vidnes
authors.forename: Ellen Drolsum
authors.initials: ED
authors.lastname: Finstad
authors.forename: Astrid Klopstad
authors.initials: AK
authors.lastname: Wahl
authors.forename: Aksel
authors.initials: A
authors.lastname: Foss
mesh_terms: D015179:Colorectal Neoplasms / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000503:physiopathology / Q000556:secondary* / Q000601:surgery; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D009664:Norway; D010865:Pilot Projects; D011446:Prospective Studies; D011788:Quality of Life; D011795:Surveys and Questionnaires