title: The relative importance of transcription rate, cryptic transcription and mRNA stability on shaping stress responses in yeast.
abstract: It has been recently stated that stress-responding genes in yeast are enriched in cryptic transcripts and that this is the cause of the differences observed between mRNA amount and RNA polymerase occupancy profiles. Other studies have shown that such differences are mainly due to modulation of mRNA stabilities. Here we analyze the relationship between the presence of cryptic transcripts in genes and their stress response profiles. Despite some of the stress-responding gene groups being indeed enriched in specific classes of cryptic transcripts, we found no statistically significant evidence that cryptic transcription is responsible for the differences observed between mRNA and transcription rate profiles.
authors.affiliation: Universitat de València, València, Spain. jose.e.perez@uv.es
authors.forename: José
authors.initials: J
authors.lastname: García-Martínez
authors.forename: Guillermo
authors.initials: G
authors.lastname: Ayala
authors.forename: Vicent
authors.initials: V
authors.lastname: Pelechano
authors.forename: Sebastián
authors.initials: S
authors.lastname: Chávez
authors.forename: Enrique
authors.initials: E
authors.lastname: Herrero
authors.forename: José E
authors.initials: JE
authors.lastname: Pérez-Ortín
mesh_terms: D012319:RNA Polymerase II / Q000235:genetics / Q000378:metabolism; D020871:RNA Stability; D012333:RNA, Messenger / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins / Q000235:genetics / Q000378:metabolism; D013312:Stress, Physiological; D014158:Transcription, Genetic / Q000235:genetics*
chemical_list: D012333:RNA, Messenger; D029701:Saccharomyces cerevisiae Proteins; D012319:RNA Polymerase II