title: Comparative efficacy of vertebroplasty, kyphoplasty, and medical therapy for vertebral fractures on survival and prevention of recurrent fractures.
abstract: OBJECTIVE
  To evaluate the efficacy of surgical and medical therapies on recurrent vertebral fracture and mortality rates.
  
  
  METHODS
  A retrospective review of medical records was performed of patients seen at Emory University Spine Center and Hospital (Atlanta, Georgia) for vertebral fracture between 1998 and 2007. Patients with vertebral fracture or who underwent vertebroplasty or kyphoplasty were identified by use of the International Classification of Diseases, Ninth Revision and Current Procedural Terminology codes, respectively. Outcome measures included site and date of recurrent vertebral fractures and mortality.
  
  
  RESULTS
  We identified 250 patients with vertebral fractures and classified them into 4 groups: surgical therapy only, surgical plus medical treatment, medical therapy only, and no treatment. There was no significant difference in the cumulative survival rates among the 4 study groups nor between the treatment groups. There was, however, a significant difference in the cumulative refracture-free rates among the 4 study groups (P<.0001). Recurrent fracture-free rates were highest in the group that received no treatment. The 2-year cumulative refracture-free rates were 95.9%, 84.8%, 81.7%, and 68.5%, respectively, for the no treatment, medical therapy only, surgical treatment only, and medical plus surgical therapy groups. Recurrent fracture-free rates were significantly different for patients who received surgical or medical or surgical plus medical therapy (P=.0007), with patients in the medical plus surgical group having the shortest time to refracture, although these patients may have been sicker and more frail than the other groups.
  
  
  CONCLUSIONS
  We found that surgical treatment with vertebroplasty or kyphoplasty did not decrease recurrent vertebral fractures in patients presenting with an initial vertebral fracture. Medical and surgical therapies together may shorten the time to refracture, but the observed elevated risk may be due to other confounding factors. We found no difference in survival in patients undergoing kyphoplasty or vertebroplasty in comparison with medical or no treatment groups. The relationship between surgical and medical therapy and vertebral refracture rates should be further evaluated with use of a prospective cohort design.
authors.affiliation: Department of Orthopedics and Spine Surgery, Emory University School of Medicine, Atlanta, GA 30322, USA.
authors.forename: Howard
authors.initials: H
authors.lastname: Levy
authors.forename: Shabnam
authors.initials: S
authors.lastname: Seydafkan
authors.forename: John D
authors.initials: JD
authors.lastname: Rice
authors.forename: Kirk A
authors.initials: KA
authors.lastname: Easley
authors.forename: Vin
authors.initials: V
authors.lastname: Tangpricha
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D050071:Bone Density Conservation Agents / Q000009:adverse effects / Q000627:therapeutic use*; D015331:Cohort Studies; D003131:Combined Modality Therapy / Q000009:adverse effects; D057286:Electronic Health Records; D005260:Female; D005500:Follow-Up Studies; D005845:Georgia / Q000453:epidemiology; D006785:Hospitals, University; D006801:Humans; D058498:Kyphoplasty / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D009026:Mortality; D010024:Osteoporosis / Q000188:drug therapy* / Q000401:mortality* / Q000503:physiopathology; D012189:Retrospective Studies; D055502:Secondary Prevention; D016103:Spinal Fractures / Q000209:etiology / Q000517:prevention & control* / Q000601:surgery*; D016019:Survival Analysis; D054854:Vertebroplasty / Q000009:adverse effects
chemical_list: D050071:Bone Density Conservation Agents