title: Apelin, a promising target for type 2 diabetes treatment?
abstract: Insulin resistance is a main feature of obesity and type 2 diabetes mellitus (T2DM). Several mechanisms linking obesity to insulin resistance have been proposed. Adipose tissue modulates metabolism by secreting a variety of factors, which exhibit altered production during obesity. Apelin, a small peptide present in a number of tissues and also produced and secreted by adipocytes, has emerged as a new player with potent functions in energy metabolism, and in insulin sensitivity improvement. In this review, we describe the various metabolic functions that are affected by apelin and we present an integrated overview of recent findings that collectively propose apelin as a promising target for the treatment of T2DM.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM), U1048, Toulouse, France.
authors.forename: Isabelle
authors.initials: I
authors.lastname: Castan-Laurell
authors.forename: Cédric
authors.initials: C
authors.lastname: Dray
authors.forename: Claude
authors.initials: C
authors.lastname: Knauf
authors.forename: Oxana
authors.initials: O
authors.lastname: Kunduzova
authors.forename: Philippe
authors.initials: P
authors.lastname: Valet
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000073861:Apelin; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007333:Insulin Resistance / Q000235:genetics / Q000502:physiology; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics / Q000378:metabolism*; D008954:Models, Biological
chemical_list: C115436:APLN protein, human; D000073861:Apelin; D036341:Intercellular Signaling Peptides and Proteins