title: The diagnostic value of a multivariate logistic regression analysis model with transvaginal power Doppler ultrasonography for the prediction of ectopic pregnancy.
abstract: OBJECTIVE
  A multivariate logistic regression analysis model for predicting ectopic pregnancy in women with pregnancy of unknown location was designed and evaluated clinically.
  
  
  METHODS
  Endometrial thickness, symmetry, resonance, pattern of echogenicity, helicine artery blood flow and blood flow resistance index (RI) in 129 patients with suspected early ectopic pregnancy were assessed by transvaginal power Doppler ultrasonography. Variables significant in univariate logistic regression analysis were included in a multivariate predictive logistic regression analysis model.
  
  
  RESULTS
  The final predictive model included three factors: endometrial thickness≤9 mm; a multilayered endometrial echogenicity pattern with prominent outer and midline hyperechogenic lines and an inner hypoechogenic region; and visible endometrial arterial blood flow. The area under the receiver operating characteristic curve of the model was 0.980. When RI was >0.65 and the predictive probability>0.50, diagnostic accuracy was high. The model correctly diagnosed 52/55 (94.5%) clinically confirmed ectopic pregnancy cases.
  
  
  CONCLUSIONS
  This multivariate predictive logistic regression analysis model has clinical value for the differential diagnosis of early ectopic pregnancy when the pregnancy location is unknown.
authors.affiliation: Department of Medical Ultrasound, Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.
authors.forename: Z-Y
authors.initials: ZY
authors.lastname: Chen
authors.forename: J-H
authors.initials: JH
authors.lastname: Liu
authors.forename: K
authors.initials: K
authors.lastname: Liang
authors.forename: W-X
authors.initials: WX
authors.lastname: Liang
authors.forename: S-H
authors.initials: SH
authors.lastname: Ma
authors.forename: G-J
authors.initials: GJ
authors.lastname: Zeng
authors.forename: S-Y
authors.initials: SY
authors.lastname: Xiao
authors.forename: J-G
authors.initials: JG
authors.lastname: He
mesh_terms: D000328:Adult; D019540:Area Under Curve; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D016015:Logistic Models; D008954:Models, Biological; D015999:Multivariate Analysis; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000000981:diagnostic imaging*; D012372:ROC Curve; D018608:Ultrasonography, Doppler / Q000379:methods*; D014621:Vagina / Q000000981:diagnostic imaging*; D055815:Young Adult