title: Nutraceutical preparations in childhood migraine prophylaxis: effects on headache outcomes including disability and behaviour.
abstract: Migraine is common in children, but few specific drugs are available. We performed an open-label comparison of effects of two nutraceutical preparations (ginkgolide B vs. Griffonia simplicifolia extract) on outcomes in 374 school-age children (mean 10.7 years) with migraine without aura. Half of them received ginkgolide B; and half, Griffonia simplicifolia. Both preparations were given orally twice a day for 6 months. Patients kept a headache diary. Outcomes at the beginning and end of treatment were compared. Both preparations reduced all outcome measures after 6 months of treatment. However, reductions in headache frequency, duration and intensity, PedMIDAS score and behavioural reactions to headache were significantly greater in the ginkgolide B group. Both nutraceutical treatments appear promising in paediatric migraine without aura, particularly because of their lack of side effects. However, the ginkgolide B preparation was significantly more effective in the medium-term (6 months).
authors.affiliation: Department of Child and Adolescent Neuropsychiatry, Center for Childhood Headache, Second University of Naples, Via Sergio Pansini 5, PAD 11, 80131, Naples, Italy.
authors.forename: Maria
authors.initials: M
authors.lastname: Esposito
authors.forename: Maria
authors.initials: M
authors.lastname: Ruberto
authors.forename: Antonio
authors.initials: A
authors.lastname: Pascotto
authors.forename: Marco
authors.initials: M
authors.lastname: Carotenuto
mesh_terms: D002648:Child; D002652:Child Behavior / Q000523:psychology*; D019587:Dietary Supplements; D004185:Disability Evaluation; D005260:Female; D046934:Ginkgolides / Q000008:administration & dosage*; D031295:Griffonia; D006801:Humans; D007783:Lactones / Q000008:administration & dosage*; D008297:Male; D008881:Migraine Disorders / Q000453:epidemiology / Q000517:prevention & control* / Q000523:psychology*; D010865:Pilot Projects; D037121:Plant Lectins / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D046934:Ginkgolides; C045475:Griffonia simplicifolia lectins; D007783:Lactones; D037121:Plant Lectins; C045856:ginkgolide B