title: Proteomic analysis for the study of amniotic fluid protein composition.
abstract: Amniotic fluid (AF), routinely used for prenatal diagnosis, contains large amounts of proteins produced by the amnion epithelial cells, fetal tissues, fetal excretions and placental tissuesAlthough many amniotic fluid proteins have been identified and are currently used to detect potential fetal anomalies, little is known about the functions of these proteins and how they interact with one another. Identification of changes in the protein content of amniotic fluid, therefore, may be used to detect a particular type of pathology, or to ascertain a specific genetic disorder. In the present work we used a proteomic approach, combining 2DE and MS, in order to study the protein composition of AFS.
authors.affiliation: Department of Biochemical Sciences "A. Rossi Fanelli", Sapienza University of Rome, Rome, Italy.
authors.forename: Marzia
authors.initials: M
authors.lastname: Perluigi
authors.forename: Fabio
authors.initials: F
authors.lastname: Di Domenico
authors.forename: Chiara
authors.initials: C
authors.lastname: Cini
authors.forename: Raffaella
authors.initials: R
authors.lastname: Coccia
authors.forename: Francesca Romana
authors.initials: FR
authors.lastname: Giorlandino
authors.forename: Maurizio
authors.initials: M
authors.lastname: Giorlandino
authors.forename: Pietro
authors.initials: P
authors.lastname: Cignini
authors.forename: Alvaro
authors.initials: A
authors.lastname: Mesoraca
authors.forename: Claudio
authors.initials: C
authors.lastname: Giorlandino