title: Postgenomic Mycobacterium leprae antigens for cellular and serological diagnosis of M. leprae exposure, infection and leprosy disease.
abstract: Due to changes in leprosy control programs and the special expertise required for diagnosis, the need for simple rapid diagnostic tests that could be applied in non-expert settings may now be greater than ever before. Since the sequencing of the M. leprae genome, many research groups have investigated the potential of M. leprae antigens in either serologic or cell mediated assays. Here we provide an overview of the nearly 200 recombinant single proteins that were investigated during the last decade for their potential to be applied in field-friendly tests for the early diagnosis of leprosy.
authors.affiliation: Department of Infectious Diseases, Leiden University Medical Center, The Netherlands. a.geluk@lumc.nl
authors.forename: Annemieke
authors.initials: A
authors.lastname: Geluk
authors.forename: Malcolm S
authors.initials: MS
authors.lastname: Duthie
authors.forename: John S
authors.initials: JS
authors.lastname: Spencer
mesh_terms: D000818:Animals; D000942:Antigens, Bacterial / Q000235:genetics* / Q000276:immunology; D001426:Bacterial Proteins / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007918:Leprosy / Q000175:diagnosis* / Q000276:immunology / Q000382:microbiology; D009166:Mycobacterium leprae / Q000235:genetics* / Q000276:immunology / Q000302:isolation & purification; D012698:Serologic Tests
chemical_list: D000942:Antigens, Bacterial; D001426:Bacterial Proteins