title: Synthesis of biodegradable polymers using biocatalysis with Yarrowia lipolytica lipase.
abstract: Yarrowia lipolytica lipase (YLL) was used as catalyst in the enzymatic ring-opening polymerization (ROP) of ε-caprolactone. This low-cost solid-state lipase produces low-molecular-weight polyesters with unique multiphase morphology as determined by carbon-13 NMR. YLL attaches sugar head groups to polycaprolactone in a one-pot biocatalytic pathway. Synthesis of α-ω-telechelic (polymer with two reactive hydroxyl end groups) PCL diols is achieved by enzymatic ROP with YLL immobilized on the macroporous resin Lewatit VPOC 1026, and in the presence of diethylene glycol or poly(ethylene glycol). Biodegradable linear polyester urethanes are prepared by polycondensation between synthesized PCL diols and hexamethylene-diisocyanate.
authors.affiliation: División de Ciencias Naturales y Exactas, Departamento de Química, Universidad de Guanajuato, Guanajuato, Mexico. fionita@ugto.mx
authors.forename: Karla A
authors.initials: KA
authors.lastname: Barrera-Rivera
authors.forename: Arturo
authors.initials: A
authors.lastname: Flores-Carreón
authors.forename: Antonio
authors.initials: A
authors.lastname: Martínez-Richa
mesh_terms: D055162:Biocatalysis; D001672:Biocompatible Materials / Q000138:chemical synthesis*; D001673:Biodegradation, Environmental; D002208:Caproates / Q000737:chemistry; D003485:Cyanates / Q000737:chemistry; D005026:Ethylene Glycols / Q000737:chemistry; D005656:Fungal Proteins / Q000737:chemistry* / Q000302:isolation & purification; D055767:Immobilized Proteins / Q000737:chemistry / Q000302:isolation & purification; D017953:Isocyanates; D007783:Lactones / Q000737:chemistry; D008049:Lipase / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D008970:Molecular Weight; D011091:Polyesters / Q000138:chemical synthesis* / Q000737:chemistry; D011092:Polyethylene Glycols / Q000737:chemistry; D025062:Yarrowia / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D002208:Caproates; D003485:Cyanates; D005026:Ethylene Glycols; D005656:Fungal Proteins; D055767:Immobilized Proteins; D017953:Isocyanates; D007783:Lactones; D011091:Polyesters; C015262:1,6-hexamethylene diisocyanate; C016240:polycaprolactone; D011092:Polyethylene Glycols; C121056:caprolactone; C013484:diethylene glycol; D008049:Lipase