title: [Influence of yi nao capsule on epinephrine and norepinephrine during rat ischemia].
abstract: OBJECTIVE
  To investigate the effect of home-made "Yi Nao Capsule" on epinephrine and norepinephrine levels in rat plasma during brain ischemia.
  
  
  METHODS
  Experiments were performed on 180 - 220 g rat under chloral hydrate anesthesia. Brain ischemia was induced by bilateral common carotid ligation for 30 min. HPLC combined with electrochemical detection has been developed for the determination of epinephrine and norepinephrine in plasma samples.
  
  
  RESULTS
  Epinephrine and norepinephrine concentration increased markedly (P<0.05) in brain ischemia rat. While the ischemia animal was fed on "Yi Nao capsule" priors to ischemia 30 min, norepinephrine and epinephrine conecentration decreased markedly (P<0.05).
  
  
  CONCLUSIONS
  Ischemia induced by bilateral common carotid ligation leads to the increase of plasma epinephrine and norepinephrine and "Yi Nao capsule" can prevent this increase.
authors.affiliation: Shangrao Company of Jiangxi Pharmaceutical Group, 334000.
authors.forename: Raohong
authors.initials: R
authors.lastname: Sun
authors.forename: Yu
authors.initials: Y
authors.lastname: Cai
authors.forename: Yanfeng
authors.initials: Y
authors.lastname: Dou
authors.forename: Lan
authors.initials: L
authors.lastname: He
authors.forename: Ronghua
authors.initials: R
authors.lastname: Zhang
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D002214:Capsules; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004837:Epinephrine / Q000097:blood* / Q000378:metabolism; D008297:Male; D009638:Norepinephrine / Q000097:blood* / Q000378:metabolism; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D002214:Capsules; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D009638:Norepinephrine; D004837:Epinephrine