title: Understanding the sexome: measuring and reporting sex differences in gene systems.
abstract: The current male bias in biomedical research should be eliminated. The large sex differences in incidence and progression of diseases mean that sex-biased factors are an untapped source of factors that protect from disease. Greater understanding will come from intensified study of the "sexome," which is the sum of sex-biased effects on gene networks and cell systems. The global search for sites and mechanisms of sex-specific regulation in diverse tissues will provide unanticipated insights into physiological regulation and targets for novel therapies.
authors.affiliation: Department of Integrative Biology and Physiology, University of California, Los Angeles, California 90095-7239, USA. arnold@ucla.edu
authors.forename: Arthur P
authors.initials: AP
authors.lastname: Arnold
authors.forename: Aldons J
authors.initials: AJ
authors.lastname: Lusis
mesh_terms: D005260:Female; D053263:Gene Regulatory Networks / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D008297:Male; D008957:Models, Genetic; D012737:Sex Factors; D059467:Transcriptome / Q000235:genetics*