title: Variability of morphometric parameters of human trabecular tissue from coxo-arthritis and osteoporotic samples.
abstract: Morphometric and architectural bone parameters change in diseases such as osteoarthritis and osteoporosis.  The mechanical strength of bone is primarily influenced by bone quantity and quality. Bone quality is defined by parameters such as trabecular thickness, trabecular separation, trabecular density and degree of anisotropy that describe the micro-architectural structure of bone.  Recently, many studies have validated microtomography as a valuable investigative technique to assess bone morphometry, thanks to micro-CT non-destructive,  non-invasive and reliability features, in comparison to traditional techniques such as histology. The aim of this study is the analysis by micro-computed tomography of six specimens, extracted from patients affected by osteoarthritis and osteoporosis, in order to observe the tridimensional structure and calculate several morphometric parameters.
authors.affiliation: Dipartimento di Ingegneria Meccanica e Aerospaziale, Sapienza Università di Roma, Rome, Italy. franco.marinozzi@uniroma1.it
authors.forename: Franco
authors.initials: F
authors.lastname: Marinozzi
authors.forename: Andrea
authors.initials: A
authors.lastname: Marinozzi
authors.forename: Fabiano
authors.initials: F
authors.lastname: Bini
authors.forename: Francesca
authors.initials: F
authors.lastname: Zuppante
authors.forename: Raffaella
authors.initials: R
authors.lastname: Pecci
authors.forename: Rossella
authors.initials: R
authors.lastname: Bedini
mesh_terms: D016880:Anisotropy; D000886:Anthropometry / Q000379:methods*; D015519:Bone Density; D005260:Female; D005270:Femur Head / Q000000981:diagnostic imaging* / Q000648:ultrastructure; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008297:Male; D015207:Osteoarthritis, Hip / Q000000981:diagnostic imaging* / Q000473:pathology; D054850:Osteophyte / Q000000981:diagnostic imaging / Q000473:pathology; D010024:Osteoporosis / Q000000981:diagnostic imaging* / Q000473:pathology; D055114:X-Ray Microtomography / Q000379:methods*