title: First detection of the equine herpesvirus 1 neuropathogenic variant in Brazil.
abstract: This report describes the first detection of an equine herpesvirus 1 (EHV-1) neuropathogenic variant (G2254/D752) in Brazil from a case of fatal equine herpesvirus myeloencephalopathy (EHM) in a mare. The results of nucleotide sequencing of the EHV-1 ORF30 gene showed that two other Brazilian EHV-1 isolates from EHM cases are representatives of the non-neuropathogenic variant (A2254/N752), suggesting that other unidentified factors are probably also involved in the neuropathogenicity of EHV-1 in horses. These findings will contribute to the epidemiological knowledge of EHV-1 infection in Brazil.
authors.affiliation: Department of Preventive Veterinary Medicine and Animal Health, Faculty of Veterinary Medicine and Animal Science (FMVZ), University of São Paulo (USP), Av. Prof. Dr Orlando Marques de Paiva 87, 05508-270, Sao Paulo, SP, Brazil. enio@usp.br
authors.forename: E
authors.initials: E
authors.lastname: Mori
authors.forename: A S
authors.initials: AS
authors.lastname: Borges
authors.forename: D J Z
authors.initials: DJ
authors.lastname: Delfiol
authors.forename: J P
authors.initials: JP
authors.lastname: Oliveira Filho
authors.forename: R C
authors.initials: RC
authors.lastname: Gonçalves
authors.forename: D Q
authors.initials: DQ
authors.lastname: Cagnini
authors.forename: M C C S H
authors.initials: MC
authors.lastname: Lara
authors.forename: E M S
authors.initials: EM
authors.lastname: Cunha
authors.forename: E M C
authors.initials: EM
authors.lastname: Villalobos
authors.forename: A F C
authors.initials: AF
authors.lastname: Nassar
authors.forename: A M M G
authors.initials: AM
authors.lastname: Castro
authors.forename: P E
authors.initials: PE
authors.lastname: Brandao
authors.forename: L J
authors.initials: LJ
authors.lastname: Richtzenhain
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology; D001938:Brazil / Q000453:epidemiology; D018792:Encephalitis, Viral / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology; D037901:Euthanasia, Animal; D017809:Fatal Outcome; D005260:Female; D006566:Herpesviridae Infections / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology; D004861:Herpesvirus 1, Equid / Q000235:genetics / Q000302:isolation & purification* / Q000472:pathogenicity; D006734:Horse Diseases / Q000453:epidemiology* / Q000473:pathology / Q000821:virology; D006736:Horses; D009187:Myelitis / Q000453:epidemiology / Q000662:veterinary* / Q000821:virology; D013116:Spinal Cord / Q000473:pathology