title: Comparison of nitroethane, 2-nitro-1-propanol, lauric acid, Lauricidin® and the Hawaiian marine algae, Chaetoceros, for potential broad-spectrum control of anaerobically grown lactic acid bacteria.
abstract: The gastrointestinal tract of bovines often contains bacteria that contribute to disorders of the rumen, and may also contain foodborne or opportunistic human pathogens as well as bacteria capable of causing mastitis in cows. Thus there is a need to develop broad-spectrum therapies that are effective while not leading to unacceptably long antibiotic withdrawal times. The effects of the CH(4)-inhibitors nitroethane (2 mg/mL), 2-nitro-1-propanol (2 mg/mL), lauric acid (5 mg/mL), the commercial product Lauricidin® (5 mg/mL), and a finely ground product of the Hawaiian marine algae, Chaetoceros (10 mg/mL), were compared in pure cultures of Streptococcus agalactia, Enterococcus faecium, Streptococcus bovis, and in a mixed lactic acid rumen bacterial culture. Lauricidin® and lauric acid exhibited the most bactericidal acidity against all bacteria. These results suggest potential animal health benefits from supplementing cattle diets with lauric acid or Lauricidin® to improve the health of the rumen and help prevent shedding of human pathogens.
authors.affiliation: Department of Animal Science, Faculty of Agriculture, University of Novi Sad, Republic of Serbia.
authors.forename: Aleksandar K
authors.initials: AK
authors.lastname: Božic
authors.forename: Robin C
authors.initials: RC
authors.lastname: Anderson
authors.forename: Steven C
authors.initials: SC
authors.lastname: Ricke
authors.forename: Philip G
authors.initials: PG
authors.lastname: Crandall
authors.forename: Corliss A
authors.initials: CA
authors.lastname: O'Bryan
mesh_terms: D000693:Anaerobiosis; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy / Q000382:microbiology / Q000517:prevention & control; D017377:Diatoms / Q000737:chemistry; D016984:Enterococcus faecium / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D004980:Ethane / Q000031:analogs & derivatives* / Q000494:pharmacology; D019344:Lactic Acid / Q000378:metabolism; D007848:Laurates / Q000494:pharmacology*; D007850:Lauric Acids / Q000494:pharmacology*; D050296:Microbial Viability / Q000187:drug effects; D050178:Monoglycerides / Q000494:pharmacology*; D009574:Nitro Compounds / Q000494:pharmacology*; D009595:Nitroparaffins / Q000494:pharmacology*; D020005:Propanols / Q000494:pharmacology*; D012417:Rumen / Q000187:drug effects / Q000382:microbiology*; D013291:Streptococcus / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism
chemical_list: C496417:2-nitropropanol; D000900:Anti-Bacterial Agents; D007848:Laurates; D007850:Lauric Acids; D050178:Monoglycerides; D009574:Nitro Compounds; D009595:Nitroparaffins; D020005:Propanols; C030358:lauric acid; C020777:monolaurin; D019344:Lactic Acid; C014705:nitroethane; D004980:Ethane