title: [Biochemical, structural and biomechanical features of human scleral matrix in primary open-angle glaucoma].
abstract: The goal of the investigation was to study the changes of scleral matrix collagen in progressing primary open-angle glaucoma (POAG). In scleral samples of 16 patients aged 52-81 years with different stages of POAG amino acid composition, collagen content and cross-linking ratio characterizing tissue rigidity were estimated. Collagen I was found to be the dominant type in sclera of glaucomatous and normal eyes, though as POAG progressing the content and cross-linking increase, that underlies the scleral rigidity increase and permeability decrease. Similar ratio of collagen cross-linking with age and glaucoma progression give evidence of specific pathologic changes of the dominant matrix component, that may be one of significant pathogenic factor of POAG.
authors.forename: E N
authors.initials: EN
authors.lastname: Iomdina
authors.forename: N Iu
authors.initials: NIu
authors.lastname: Ignat'eva
authors.forename: N A
authors.initials: NA
authors.lastname: Danilov
authors.forename: L L
authors.initials: LL
authors.lastname: Arutiunian
authors.forename: O A
authors.initials: OA
authors.lastname: Kiseleva
authors.forename: L A
authors.initials: LA
authors.lastname: Nazarenko
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000596:Amino Acids / Q000032:analysis / Q000378:metabolism; D003094:Collagen / Q000032:analysis / Q000378:metabolism*; D005260:Female; D005902:Glaucoma, Open-Angle / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012590:Sclera / Q000737:chemistry / Q000378:metabolism* / Q000473:pathology
chemical_list: D000596:Amino Acids; D003094:Collagen