title: Study of the role of interleukin-6 and highly sensitive C-reactive protein in diabetic nephropathy in type 1 diabetic patients.
abstract: BACKGROUND
  Diabetes Mellitus (DM) is becoming an increasingly common disease which is the leading cause of chronic renal failure. The pathogenesis of diabetic nephropathy is still a matter of debate. There are conflicting results regarding the relation of C reactive protein (CRP), interleukin-6 (IL-6) and diabetic nephropathy in type 1 diabetes.
  
  
  OBJECTIVE
  This study was aiming to determine the association between higly sensitive (Hs)-CRP and IL6 with nephropathy in a sample of type 1 diabetic Egyptian patients.
  
  
  METHODS
  The study was conducted on forty type-1 diabetic patients (Group I), who subdivided into three subgroups according to their urine albumin excretion rate (AER); Group IA: 10 patients with AER <20 microg/min, Group IB: 15 patients with AER ranges from 20-200 microg/min. Group IC: 15 patients with AER is > 200 microg/min and 10 healthy subjects as a control (Group II).
  
  
  RESULTS
  There were high statistical significant difference (p < 0.001) between group I with group II regarding HsCRP (4.39 +/- 1.94, 1.32 +/- 0.39), and IL-6 (2.82 +/- 0.76, 1.95 +/- 0.35). In group I, we found a positive significant correlation (p < 0 .001) between UAE and levels of Hs-CRP (r = 0.927), and IL-6 (r = 0.838), respectively. Also, a positive significant correlation between Hs-CRP and IL-6 (r = 0.728, p < 0.001) was found. Fasting plasma glucose (FPG) level and HbA1c showed a significant positive correlation (p < 0.001) with Hs-CRP (r = 0.531) (r = 0.750), and IL-6 (r = 0. 490) (r = 0.680) respectively.
  
  
  CONCLUSIONS
  Hs-CRP and IL-6 are sensitive markers for diabetic nephropathy predicting its progression and severity in type 1 diabetics.
authors.affiliation: Department of Internal Medicine, Endocrine Unit, School of Medicine, Ain Shams University, Cairo, Egypt.
authors.forename: S
authors.initials: S
authors.lastname: Shelbaya
authors.forename: H
authors.initials: H
authors.lastname: Amer
authors.forename: S
authors.initials: S
authors.lastname: Seddik
authors.forename: A A
authors.initials: AA
authors.lastname: Allah
authors.forename: I M
authors.initials: IM
authors.lastname: Sabry
authors.forename: T
authors.initials: T
authors.lastname: Mohamed
authors.forename: M
authors.initials: M
authors.lastname: El Mosely
mesh_terms: D000293:Adolescent; D000328:Adult; D000419:Albuminuria / Q000378:metabolism; D001786:Blood Glucose / Q000032:analysis; D002097:C-Reactive Protein / Q000378:metabolism / Q000502:physiology*; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism*; D003929:Diabetic Neuropathies / Q000378:metabolism*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D015850:Interleukin-6 / Q000502:physiology*; D008055:Lipids / Q000097:blood; D008297:Male; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D002097:C-Reactive Protein; D006442:Glycated Hemoglobin; D015850:Interleukin-6; D008055:Lipids