title: Sodium 1-naphthalenesulfonate-functionalized reduced graphene oxide stabilizes silver nanoparticles with lower cytotoxicity and long-term antibacterial activity.
abstract: Silver nanoparticles (AgNPs) are increasingly used in daily life for their antibacterial properties, but their low stability and high cytotoxicity hamper practical applications. In this work, sodium 1-naphthalenesulfonate-functionalized reduced graphene oxide (NA-rGO) was used as a substrate for AgNPs to produce a AgNP-NA-rGO hybrid. This hybrid showed substantially higher antibacterial activity than polyvinyl pyrrolidone (PVP)-stabilized AgNPs, and the AgNPs on NA-rGO were more stable than the AgNPs on PVP, resulting in long-term antibacterial effects. More importantly, this hybrid showed excellent water solubility and low cytotoxicity, suggesting the great potential application as sprayable reduced graphene oxide based antibacterial solutions.
authors.affiliation: Department of Chemistry, Jinan University, Guangzhou 510632, PR China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Cai
authors.forename: Shaozao
authors.initials: S
authors.lastname: Tan
authors.forename: Aili
authors.initials: A
authors.lastname: Yu
authors.forename: Jinglin
authors.initials: J
authors.lastname: Zhang
authors.forename: Jiahao
authors.initials: J
authors.lastname: Liu
authors.forename: Wenjie
authors.initials: W
authors.lastname: Mai
authors.forename: Zhenyou
authors.initials: Z
authors.lastname: Jiang
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004355:Drug Stability; D004926:Escherichia coli / Q000187:drug effects; D004927:Escherichia coli Infections / Q000188:drug therapy; D006108:Graphite / Q000737:chemistry* / Q000494:pharmacology; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D009282:Naphthalenesulfonates / Q000737:chemistry* / Q000494:pharmacology; D010084:Oxidation-Reduction; D010087:Oxides / Q000737:chemistry* / Q000494:pharmacology; D012834:Silver / Q000737:chemistry* / Q000494:pharmacology; D012995:Solubility; D013203:Staphylococcal Infections / Q000188:drug therapy; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D009282:Naphthalenesulfonates; D010087:Oxides; D012834:Silver; D006108:Graphite