title: Influence of dihydroergotoxine, bromocriptine, and ergotamine on penile erection in Wistar rats.
abstract: The pilot study presented was conducted to determine as to whether ergot  alkaloids (alpha-adrenergic blockers) have a potential effect on penile  erectile function. The influence of dihydroergotoxine, bromocriptine, and  ergotamine was studied on the erection ability in intact, two-grade outbred  male Wistar albino rats that were out of their estrous phase. The experimental  animals were injected intrapenially with the substances under examination:  dihydroergotoxine mesylate (0.1 mg/0.1 mL, 0.3 mg/0.1 mL, and 1 mg/0.1 mL),  bromocriptine mesylate (0.3 mg/0.1 mL, 1 mg/0.1 mL, and 3 mg/0.1 mL), and  ergotamine tartrate (0.1 mg/0.1 mL, 0.3 mg/0.1 mL, and 1mg/0.1 mL). Every dose  was tested on a pattern of 30 rats. These mentioned substances were injected  in the amount of 1 mm to the left of the proximal part of the superficial  dorsal vein of the penis, in the region of the penis root. After injection,  the animals were then observed within the next 90 minutes. In the trial, the  following was observed: the number of rats with an erection achieved, the  period of time from intrapenial application to the appearance of the first  erection, and the duration of the erection. Ultimately, the research results  confirm the efficiency of dihydroergotoxine and bromocriptine as erectogenic  agents, as well as ergotamine as a detumescent compared with saline  solutions.
authors.affiliation: Department of Forensic Medicine, Clinical Centre of Montenegro, 2000 Podgorica, Ljubljanska 1, Montenegro.
authors.forename: Milovan
authors.initials: M
authors.lastname: Radosavljevic
authors.forename: Bogdan
authors.initials: B
authors.lastname: Pajovic
authors.forename: Miodrag
authors.initials: M
authors.lastname: Radunovic
authors.forename: Nemanja
authors.initials: N
authors.lastname: Radojevic
authors.forename: Bojana
authors.initials: B
authors.lastname: Bjelogrlic
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001971:Bromocriptine / Q000008:administration & dosage / Q000494:pharmacology*; D004088:Dihydroergotoxine / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004878:Ergotamine / Q000008:administration & dosage / Q000494:pharmacology*; D007275:Injections, Intravenous; D008297:Male; D010410:Penile Erection / Q000187:drug effects*; D010413:Penis / Q000098:blood supply / Q000187:drug effects*; D010865:Pilot Projects; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time; D013997:Time Factors
chemical_list: D000317:Adrenergic alpha-Antagonists; D004088:Dihydroergotoxine; D001971:Bromocriptine; D004878:Ergotamine