title: Variations in the number of CCL3L1 gene copies and Kawasaki disease in Korean children.
abstract: High-dose intravenous immunoglobulin (IVIG) therapy is the highly effective and standard treatment for Kawasaki disease (KD). However, ~20 % of KD patients have persistent fever or recurrence of fever after the initial IVIG treatment, which increases the risk for coronary artery lesions (CALs). Furthermore, the mechanism of IVIG resistance in KD patients still is unknown. The number of CC chemokine ligand 3-like 1 (CCL3L1) gene copies is reported to be associated with KD and IVIG resistance in Japanese patients. In addition, the authors observed significant upregulation of the CCL3L1 gene expression after in vitro immunoglobulin treatment in B cell lines derived from KD patients. Therefore, this study of 459 KD patients and 496 healthy control subjects tested whether the number of CCL3L1 gene copies is associated with a risk of KD, CALs, and/or IVIG resistance in Korean KD patients. However, the number of CCL3L1 gene copies was not associated with KD (P = 0.18), CAL formation (P = 0.062), or the IVIG resistance (P = 0.90). Therefore, the results indicate that the number of CCL3L1 gene copies does not have a role in susceptibility to KD or CALs nor with IVIG resistance in Korean KD patients.
authors.affiliation: Asan Institute for Life Sciences, University of Ulsan College of Medicine, 388-1 Pungnap-2-Dong, Songpa-Gu, Seoul, Korea.
authors.forename: Hye-Eun
authors.initials: HE
authors.lastname: Kim
authors.forename: Jae-Jung
authors.initials: JJ
authors.lastname: Kim
authors.forename: Myung Ki
authors.initials: MK
authors.lastname: Han
authors.forename: Kyung-Yil
authors.initials: KY
authors.lastname: Lee
authors.forename: Min Seob
authors.initials: MS
authors.lastname: Song
authors.forename: Hyoung-Doo
authors.initials: HD
authors.lastname: Lee
authors.forename: Dong Soo
authors.initials: DS
authors.lastname: Kim
authors.forename: Jeong Jin
authors.initials: JJ
authors.lastname: Yu
authors.forename: In-Sook
authors.initials: IS
authors.lastname: Park
authors.forename: Sin Weon
authors.initials: SW
authors.lastname: Yun
authors.forename: Young Mi
authors.initials: YM
authors.lastname: Hong
authors.forename: Gi Young
authors.initials: GY
authors.lastname: Jang
authors.forename: Jong-Keuk
authors.initials: JK
authors.lastname: Lee
mesh_terms: D016022:Case-Control Studies; D019742:Chemokines, CC / Q000235:genetics*; D016009:Chi-Square Distribution; D002648:Child; D004351:Drug Resistance / Q000187:drug effects*; D004452:Echocardiography; D005260:Female; D015870:Gene Expression; D020022:Genetic Predisposition to Disease; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000235:genetics*; D056910:Republic of Korea; D015854:Up-Regulation
chemical_list: C492767:CCL3L1 protein, human; D019742:Chemokines, CC; D016756:Immunoglobulins, Intravenous