title: Comparison of angiogenic and anti-angiogenic factors in maternal and umbilical cord blood in early- and late-onset pre-eclampsia.
abstract: OBJECTIVE
  The aim of this study was to compare maternal and umbilical cord serum levels of the angiogenic and anti-angiogenic factors in early- and late-onset pre-eclamptic pregnancies as well as in normal pregnancies, which might have significant importance in the etiology of pre-eclampsia.
  
  
  METHODS
  This prospective case-control study was carried out with pre-eclamptic (early-onset, ≤ 34 weeks and late-onset, >34 weeks) and normal pregnant women. VEGF, PIGF, sFlt-1 and sEng levels in maternal and umbilical cord serum were measured before delivery and the findings were compared.
  
  
  RESULTS
  The study was conducted with 15 early- and 15 late-onset pre-eclampsia patients, and 17 patients with normal pregnancies. It was found that sEng levels were higher in the umbilical cord serum in the early-onset and in the maternal serum in the late-onset pre-eclampsia group than the control group (p < 0.05). No significant difference in any factor was observed between the early- and late-onset pre-eclampsia groups.
  
  
  CONCLUSIONS
  In this study, the results showed that angiogenic and anti-angiogenic factor levels in maternal serum and umbilical cord serum may not be related to the time of onset of pre-eclampsia.
authors.affiliation: Department of Obstetrics and Gynecology, Adnan Menderes University, Faculty of Medicine, Aydın, Turkey. sdemircansezer@gmail.com
authors.forename: Selda Demircan
authors.initials: SD
authors.lastname: Sezer
authors.forename: Mert
authors.initials: M
authors.lastname: Küçük
authors.forename: Ciğdem
authors.initials: C
authors.lastname: Yenisey
authors.forename: Hasan
authors.initials: H
authors.lastname: Yüksel
authors.forename: Ali Rıza
authors.initials: AR
authors.lastname: Odabaşı
authors.forename: Münevver Kaynak
authors.initials: MK
authors.lastname: Türkmen
authors.forename: Bilin
authors.initials: B
authors.lastname: Çetinkaya Çakmak
authors.forename: Imran Kurt
authors.initials: IK
authors.lastname: Ömürlü
mesh_terms: D000328:Adult; D020533:Angiogenesis Inhibitors / Q000097:blood*; D042501:Angiogenic Proteins / Q000097:blood*; D015703:Antigens, CD / Q000097:blood / Q000737:chemistry; D016022:Case-Control Studies; D000071063:Endoglin; D005260:Female; D005312:Fetal Blood; D006801:Humans; D008565:Membrane Proteins / Q000097:blood; D011225:Pre-Eclampsia / Q000097:blood* / Q000453:epidemiology / Q000503:physiopathology*; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D011446:Prospective Studies; D011956:Receptors, Cell Surface / Q000097:blood / Q000737:chemistry; D012720:Severity of Illness Index; D012995:Solubility; D014421:Turkey / Q000453:epidemiology; D042461:Vascular Endothelial Growth Factor A / Q000097:blood; D040281:Vascular Endothelial Growth Factor Receptor-1 / Q000097:blood / Q000737:chemistry; D055815:Young Adult
chemical_list: D020533:Angiogenesis Inhibitors; D042501:Angiogenic Proteins; D015703:Antigens, CD; C064206:ENG protein, human; D000071063:Endoglin; D008565:Membrane Proteins; C098069:PIGF protein, human; D011956:Receptors, Cell Surface; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; C501162:FLT1 protein, human; D040281:Vascular Endothelial Growth Factor Receptor-1