title: MicroRNA regulation in experimental autoimmune encephalomyelitis in mice and marmosets resembles regulation in human multiple sclerosis lesions.
abstract: Here we demonstrate that miRNA regulation in marmoset (Callithrix jacchus) and C57/BL6 mouse EAE lesions largely resembles miRNA regulation in active human MS lesions. Detailed quantitative PCR analyses of the most up- and downregulated miRNAs of active human MS lesions in dissected lesions from marmoset EAE brains and inflamed spinal cords of EAE mice revealed that the conserved and highly regulated miRNAs, miRNA-155, miRNA-142-3p, miRNA-146a, miRNA-146b and miRNA-21, turned out to be similarly upregulated in marmoset and mouse EAE lesions.
authors.affiliation: Department of Neuropathology, University of Göttingen, Göttingen, Germany.
authors.forename: Juliane
authors.initials: J
authors.lastname: Lescher
authors.forename: Franziska
authors.initials: F
authors.lastname: Paap
authors.forename: Verena
authors.initials: V
authors.lastname: Schultz
authors.forename: Laura
authors.initials: L
authors.lastname: Redenbach
authors.forename: Uta
authors.initials: U
authors.lastname: Scheidt
authors.forename: Hendrik
authors.initials: H
authors.lastname: Rosewich
authors.forename: Stefan
authors.initials: S
authors.lastname: Nessler
authors.forename: Eberhard
authors.initials: E
authors.lastname: Fuchs
authors.forename: Jutta
authors.initials: J
authors.lastname: Gärtner
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Brück
authors.forename: Andreas
authors.initials: A
authors.lastname: Junker
mesh_terms: D000818:Animals; D002144:Callithrix; D015536:Down-Regulation / Q000276:immunology; D006801:Humans; D018836:Inflammation Mediators / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D035683:MicroRNAs / Q000037:antagonists & inhibitors* / Q000096:biosynthesis* / Q000494:pharmacology; D009103:Multiple Sclerosis / Q000235:genetics* / Q000378:metabolism / Q000473:pathology*; D015854:Up-Regulation / Q000276:immunology
chemical_list: D018836:Inflammation Mediators; C524940:MIRN21 microRNA, human; D035683:MicroRNAs