title: Activity of mitochondrial ATP-dependent potassium channel in animals with different resistance to hypoxia before and after the course of hypoxic training.
abstract: Activity of mitochondrial ATP-dependent potassium channel in rats with high genetically determined resistance to hypoxia was higher than in sensitive animals. Adaptation of low resistant rats to hypoxia was accompanied by activation of the channel, facilitation of potassium recycling in mitochondria, and a decrease in the rate of H2O2 formation. Our results indicate that mitochondrial ATP-dependent potassium channel plays an important role in the delayed mechanisms of animal's adaptation to hypoxia.
authors.affiliation: Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow region, Russia.
authors.forename: G D
authors.initials: GD
authors.lastname: Mironova
authors.forename: M I
authors.initials: MI
authors.lastname: Shigaeva
authors.forename: E N
authors.initials: EN
authors.lastname: Gritsenko
authors.forename: S V
authors.initials: SV
authors.lastname: Murzaeva
authors.forename: E L
authors.initials: EL
authors.lastname: Germanova
authors.forename: O S
authors.initials: OS
authors.lastname: Gorbacheva
authors.forename: L D
authors.initials: LD
authors.lastname: Lukyanova
mesh_terms: D000064:Acclimatization / Q000502:physiology*; D000255:Adenosine Triphosphate / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D060467:Disease Resistance; D006861:Hydrogen Peroxide / Q000378:metabolism; D000860:Hypoxia / Q000235:genetics / Q000378:metabolism* / Q000503:physiopathology; D054086:KATP Channels / Q000819:agonists / Q000378:metabolism*; D008297:Male; D008929:Mitochondria, Heart / Q000187:drug effects / Q000378:metabolism; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism; D011188:Potassium / Q000378:metabolism*; D051381:Rats
chemical_list: D054086:KATP Channels; D000255:Adenosine Triphosphate; D006861:Hydrogen Peroxide; D011188:Potassium