title: Types of maternal hypertensive disease and their association with pathologic lesions and clinical factors.
abstract: Hypertensive disease (HD) during pregnancy includes chronic hypertension (HTN), gestational hypertension (GH), and preeclampsia/eclampsia (PEC). Differences between types of HD have not been well studied. Clinicopathologic features were compared between the HD groups and controls. HD was associated with lower Apgar scores, intrauterine growth restriction, IUGR, and delivery at an earlier gestational age (GA). IUGR was less common in the GH group, gestational age was lowest in the PEC. As expected, HD is associated with placental lesions of malperfusion, younger GA, and increased incidence of IUGR and controls showed less chronic and more "acute" lesions (ACA, MEC). Finally, comparisons of the HD groups showed differences only in GA and IUGR in the GH group as compared to the HTN and PEC groups. This suggests that GH may be associated with less severe clinical disease while showing similar pathologic features.
authors.affiliation: Department of Pathology and Laboratory Medicine, Weill Cornell Medical College - New York Presbyterian Hospital, New York, New York, USA.
authors.forename: Katherine F
authors.initials: KF
authors.lastname: Maloney
authors.forename: Debra
authors.initials: D
authors.lastname: Heller
authors.forename: Rebecca N
authors.initials: RN
authors.lastname: Baergen
mesh_terms: D000328:Adult; D001034:Apgar Score; D002908:Chronic Disease; D015897:Comorbidity; D004461:Eclampsia / Q000453:epidemiology / Q000473:pathology*; D005260:Female; D005317:Fetal Growth Retardation / Q000453:epidemiology / Q000473:pathology; D005865:Gestational Age; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000473:pathology*; D007231:Infant, Newborn; D009519:New York City / Q000453:epidemiology; D007752:Obstetric Labor, Premature / Q000453:epidemiology; D010920:Placenta / Q000473:pathology*; D010922:Placenta Diseases / Q000453:epidemiology / Q000473:pathology*; D011225:Pre-Eclampsia / Q000453:epidemiology / Q000473:pathology*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000453:epidemiology / Q000473:pathology*; D047928:Premature Birth / Q000453:epidemiology