title: Comparative analysis of Japanese and foreign L-type BSE prions.
abstract: L-type bovine spongiform encephalopathy (BSE) is an atypical form of BSE. To characterize the Japanese L-type BSE prion, we conducted a comparative study of the Japanese and foreign L-type BSE isolates. The L-type BSE isolates of Japan, Germany, France and Canada were intracerebrally inoculated into bovinized prion protein-overexpressing transgenic mice (TgBoPrP). All the examined L-type BSE isolates were transmitted to TgBoPrP mice, and no clear differences were observed in their biological and biochemical properties. Here, we present evidence that the Japanese and Canadian L-type BSE prions are identical to those from the European cases.
authors.affiliation: Prion Disease Research Center, National Institute of Animal Health, Tsukuba, Ibaraki, Japan.
authors.forename: Kentaro
authors.initials: K
authors.lastname: Masujin
authors.forename: Ritsuko
authors.initials: R
authors.lastname: Miwa
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Okada
authors.forename: Shirou
authors.initials: S
authors.lastname: Mohri
authors.forename: Takashi
authors.initials: T
authors.lastname: Yokoyama
mesh_terms: D000818:Animals; D015153:Blotting, Western; D001921:Brain / Q000378:metabolism / Q000473:pathology; D002417:Cattle; D016643:Encephalopathy, Bovine Spongiform / Q000453:epidemiology / Q000378:metabolism* / Q000635:transmission; D019286:Endopeptidase K / Q000378:metabolism; D007564:Japan / Q000453:epidemiology; D051379:Mice; D008822:Mice, Transgenic; D011328:Prions / Q000378:metabolism*
chemical_list: D011328:Prions; D019286:Endopeptidase K