title: Evaluation and differential diagnosis of marked, persistent eosinophilia.
abstract: High-grade eosinophilia can be a diagnostic dilemma, as the etiologies are extensive and varied. Hypereosinophilic syndromes (HES) are a group of heterogeneous disorders, many of which remain poorly defined. By definition, HES must be distinguished from other disorders with persistently elevated eosinophilia with a defined cause. Although marked eosinophilia worldwide is most commonly caused by helminth (worm) infections, non-infectious causes must be considered, and include drug reactions, malignancies, and immunologic, inflammatory and allergic diseases.
authors.affiliation: Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA.
authors.forename: Rojelio
authors.initials: R
authors.lastname: Mejia
authors.forename: Thomas B
authors.initials: TB
authors.lastname: Nutman
mesh_terms: D000818:Animals; D003937:Diagnosis, Differential; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000175:diagnosis* / Q000276:immunology*; D006967:Hypersensitivity / Q000175:diagnosis / Q000276:immunology; D007249:Inflammation / Q000175:diagnosis / Q000276:immunology