title: Highly oxygenated stigmastane-type steroids from the aerial parts of Vernonia anthelmintica Willd.
abstract: Nine new highly oxygenated stigmastane-type steroids, vernoanthelcin A-I (1-9), and two new stigmastane-type steroidal glycosides, vernoantheloside A and B (10 and 11) were isolated from the aerial parts of Vernonia anthelmintica Willd. The structures of compounds 1-11 were determined on the basis of IR, MS, 1D-NMR, and 2D-NMR, and their absolute configurations were deduced using single-crystal X-ray diffraction and the CD exciton chirality method. Compounds 1, 5, 7, 9 and 10 were tested for their effects on estrogen biosynthesis in human ovarian granulosa-like cells (KGN cells).
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, People's Republic of China.
authors.forename: Lei
authors.initials: L
authors.lastname: Hua
authors.forename: Wei-Yan
authors.initials: WY
authors.lastname: Qi
authors.forename: Syed Hamid
authors.initials: SH
authors.lastname: Hussain
authors.forename: Kun
authors.initials: K
authors.lastname: Gao
authors.forename: Mohammad
authors.initials: M
authors.lastname: Arfan
mesh_terms: D019659:Asteraceae / Q000737:chemistry*; D002478:Cells, Cultured; D002942:Circular Dichroism; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D013256:Steroids