title: The quest for diagnostic molecular markers for thyroid nodules with indeterminate or suspicious cytology.
abstract: Thyroid nodules are very common and fine needle aspiration (FNA) is a very sensitive means of diagnosis. However, its limitations include the fact that the cytology reports are often indeterminate or suspicious only. The quest for adjunctive measures to improve its specificity has been ongoing for decades, but significant results have remained elusive. The potential use of diagnostic molecular markers appears to be the most promising area of research at this time.
authors.affiliation: Division of Endocrine Surgery, Department of Surgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.
authors.forename: Guennadi
authors.initials: G
authors.lastname: Kouniavsky
authors.forename: Martha A
authors.initials: MA
authors.lastname: Zeiger
mesh_terms: D017398:Alternative Splicing; D014408:Biomarkers, Tumor / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D044963:Biopsy, Fine-Needle; D002869:Chromosome Aberrations; D003937:Diagnosis, Differential; D015972:Gene Expression Regulation, Neoplastic; D015321:Gene Rearrangement; D006801:Humans; D007150:Immunohistochemistry; D035683:MicroRNAs / Q000235:genetics; D009154:Mutation; D015588:Observer Variation; D016133:Polymerase Chain Reaction; D040081:Protein Array Analysis; D016606:Thyroid Nodule / Q000097:blood / Q000175:diagnosis* / Q000201:enzymology / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D057170:Translational Research, Biomedical / Q000639:trends
chemical_list: D014408:Biomarkers, Tumor; D035683:MicroRNAs