title: Preparation of quinazolino[3,2-a]quinazolines via a palladium-catalyzed three-component reaction of carbodiimide, isocyanide, and amine.
abstract: A palladium-catalyzed three-component reaction of bis-(2-iodoaryl)carbodiimide, isocyanide, and amine gives rise to quinazolino[3,2-a]quinazolines and related compounds in good yields. Multi-bonds are formed in one pot through nucleophilic attack, isocyanide insertion, and C-N coupling during the reaction process.
authors.affiliation: Department of Chemistry, Fudan University, 220 Handan Road, Shanghai 200433, China.
authors.forename: Guanyinsheng
authors.initials: G
authors.lastname: Qiu
authors.forename: Yaohua
authors.initials: Y
authors.lastname: He
authors.forename: Jie
authors.initials: J
authors.lastname: Wu
mesh_terms: D000588:Amines / Q000737:chemistry*; D002234:Carbodiimides / Q000737:chemistry*; D002384:Catalysis; D003486:Cyanides / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry*; D011799:Quinazolines / Q000138:chemical synthesis / Q000737:chemistry*
chemical_list: D000588:Amines; D002234:Carbodiimides; D003486:Cyanides; D011799:Quinazolines; D010165:Palladium