title: Neuroendocrinology-based therapy for Alzheimer's disease.
abstract: The nervous system interacts directly with the endocrine system to control a plethora of central nervous system (CNS) functions. Metabolic and reproductive hormones are known to be important in the maintenance of neuronal health and their fluctuations are important for CNS aspects ranging from sleep and appetite regulation to cognitive function. This review will summarize and critically evaluate how age-related changes in sex and metabolic hormones modulate affect cognitive function and the implications of targeting the neuroendocrinological system as a therapeutic strategy in Alzheimer's disease.
authors.affiliation: Department of Neurosciences, Case Western Reserve University, Cleveland, OH, USA.
authors.forename: Russell
authors.initials: R
authors.lastname: Palm
authors.forename: Nilmarie
authors.initials: N
authors.lastname: Ayala-Fontanez
authors.forename: Yoelvis
authors.initials: Y
authors.lastname: Garcia
authors.forename: Hyoung-Gon
authors.initials: HG
authors.lastname: Lee
authors.forename: Mark A
authors.initials: MA
authors.lastname: Smith
authors.forename: Gemma
authors.initials: G
authors.lastname: Casadesus
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000378:metabolism*; D003071:Cognition / Q000187:drug effects / Q000502:physiology; D006728:Hormones / Q000378:metabolism*; D006801:Humans; D009452:Neuroendocrinology / Q000379:methods*
chemical_list: D006728:Hormones