title: Effects of CYP1A2 gene polymorphisms on antipyrine CYP1A2-dependent metabolism.
abstract: The distribution of two CYP1A2 gene polymorphisms, CYP1A2*F and CYP1A2*D, was studied in a group of 38 men. Antipyrine elimination test was carried out and urinary cotinine was measured. The contribution of these CYP1A2 gene polymorphisms, age, and tobacco smoking to accumulation of three main antipyrine metabolites in the urine was evaluated by regression analysis. The impact of both studied polymorphisms was essential for urinary levels of 3-hydroxymethylantipyrine (metabolite most dependent on cytochrome P-4501A2) and hence, for functional activity of this isoform of the enzyme.
authors.affiliation: Angarsk Affiliated Department of East Siberian Center of Human Ecology, Siberian Division of Russian Academy of Medical Sciences, Russia. yuri_chernyak@ang.ru
authors.forename: Yu I
authors.initials: YI
authors.lastname: Chernyak
authors.forename: V B
authors.initials: VB
authors.lastname: Itskovich
authors.forename: S I
authors.initials: SI
authors.lastname: Kolesnikov
mesh_terms: D000328:Adult; D000983:Antipyrine / Q000378:metabolism*; D001483:Base Sequence; D019388:Cytochrome P-450 CYP1A2 / Q000235:genetics*; D017931:DNA Primers; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic
chemical_list: D017931:DNA Primers; C504573:CYP1A2 protein, human; D019388:Cytochrome P-450 CYP1A2; D000983:Antipyrine