title: The relationship of epicardial adipose tissue thickness to clinical and biochemical features in women with polycystic ovary syndrome.
abstract: The amount of epicardial adipose tissue (EAT), a component of body visceral adiposity, has been linked to the presence and severity of cardiovascular disease through multiple mechanisms. Polycystic ovary syndrome (PCOS) is characterized by insulin resistance and subclinical inflammation, which participate in the mechanism of atherosclerosis. We searched if the patients with PCOS have increased EAT thickness (EATT), along with its relation to the measures of adiposity and insulin sensitivity. A total of 41 subjects with PCOS and 46 age and body mass index (BMI) matched healthy controls were enrolled. EAT was measured by echocardiography above the free wall of the right ventricle. Insulin resistance was assessed by homeostasis model assessment of insulin resistance (HOMA-IR) formula, and plasma adiponectin level was measured by ELISA. Compared to healthy controls EATT and HOMA-IR score were significantly higher (p=0.0001 for both) while plasma adiponectin concentration was significantly lower (p=0.048) in women with PCOS. EATT correlated positively with total cholesterol, triglyceride, luteinizing hormone (LH) and negatively with sex hormon binding globuline (p<0.05 for all), whereas it displayed no correlation to plasma adiponectin level (p=0.924). Triglyceride level was the significant determinant of EATT in logistic regression analysis (p=0.035). Thickness of the EAT is increased in patients with PCOS in conjunction with hyperandrogenity. Prospective studies are required to identify the relation of EAT and cardiovascular risk in patients with PCOS.
authors.affiliation: Department of Endocrinology and Metabolism, Gulhane School of Medicine, Ankara, Turkey. draydoganaydogdu@gmail.com
authors.forename: Aydogan
authors.initials: A
authors.lastname: Aydogdu
authors.forename: Gokhan
authors.initials: G
authors.lastname: Uckaya
authors.forename: Ilker
authors.initials: I
authors.lastname: Tasci
authors.forename: Oben
authors.initials: O
authors.lastname: Baysan
authors.forename: Serkan
authors.initials: S
authors.lastname: Tapan
authors.forename: Baris
authors.initials: B
authors.lastname: Bugan
authors.forename: Muhittin
authors.initials: M
authors.lastname: Serdar
authors.forename: Halil
authors.initials: H
authors.lastname: Akbulut
authors.forename: Umit
authors.initials: U
authors.lastname: Aydogan
authors.forename: Alper
authors.initials: A
authors.lastname: Sonmez
authors.forename: Sebnem
authors.initials: S
authors.lastname: Aydogdu
authors.forename: Mustafa
authors.initials: M
authors.lastname: Kutlu
mesh_terms: D052242:Adiponectin / Q000097:blood; D000273:Adipose Tissue / Q000000981:diagnostic imaging*; D000293:Adolescent; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000209:etiology; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D004452:Echocardiography; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D016015:Logistic Models; D007986:Luteinizing Hormone / Q000097:blood; D010496:Pericardium / Q000000981:diagnostic imaging*; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D012307:Risk Factors; D012738:Sex Hormone-Binding Globulin / Q000032:analysis; D014280:Triglycerides / Q000097:blood; D055815:Young Adult
chemical_list: D052242:Adiponectin; D012738:Sex Hormone-Binding Globulin; D014280:Triglycerides; D007986:Luteinizing Hormone; D002784:Cholesterol