title: [Chronic stress and epigenetics. Relation between academic sciences and theology].
abstract: The author gives a short account on the principles of Selye's stress theory, and discusses similarities and dissimilarities of acute and chronic stress. Both the external, and the internal environment, as well as the psycho-mental status are involved in the notion of the environment. Basic principles of epigenetics are reviewed: interaction between environment and genes, neuroendocrine and enzymatic mechanisms involved in silencing and activation of genes, notions of phenotypic plasticity, and epigenetic reprogramming are discussed. Epigenetic mechanisms of interrelation between pathological clinical states (diseases) and the characteristic phenotypes, causative role of psycho-mental status in evoking pathological somatic alterations, and the potential therapeutic consequences are briefly discussed. The etiological role of chronic, civilization stress in producing the worldwide increment of cardiovascular morbidity is cited, argumentation and criticism of the current therapeutical practice is discussed. The author concludes that recent advances in epigenetic knowledge seem to solve the controversy between the academic and theological sciences.
authors.affiliation: Siófok Város Kórház-Rendelőintézete Belgyógyászati Osztály Siófok Semmelweis u. 1. 8600. kornelsimon@datatrans.hu
authors.forename: Kornél
authors.initials: K
authors.lastname: Simon
mesh_terms: D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000235:genetics / Q000523:psychology; D002908:Chronic Disease; D044127:Epigenesis, Genetic; D057890:Epigenomics; D020868:Gene Silencing; D006801:Humans; D009017:Morbidity; D010641:Phenotype; D011602:Psychophysiologic Disorders / Q000453:epidemiology / Q000235:genetics / Q000523:psychology; D013315:Stress, Psychological / Q000150:complications* / Q000235:genetics*; D028725:Theology; D015533:Transcriptional Activation