title: The clinical significance of indomethacin-probenecid interaction.
abstract: 1 The effect of the addition of probenecid to oral and rectal regimes of indomethacin was studied in three groups of rheumatoid arthritic patients. 2 The addition of probenecid increases plasma levels of indomethacin given both orally and rectally and significantly reduces the clinical parameters of joint inflammation. 3 The use of probenecid with indomethacin at night may be useful in reducing morning stiffness and pain. 4 Though indomethacin plasma levels are markedly raised during concurrent probenecid therapy remarkably few side effects were observed.
authors.affiliation: Centre for Theumatic Diseases and University Department of Medicine, Royal Infirmary, Glasgow.
authors.forename: P M
authors.initials: PM
authors.lastname: Brooks
authors.forename: M A
authors.initials: MA
authors.lastname: Bell
authors.forename: R D
authors.initials: RD
authors.lastname: Sturrock
authors.forename: J P
authors.initials: JP
authors.lastname: Famaey
authors.forename: W C
authors.initials: WC
authors.lastname: Dick