title: Binaural interactions develop in the auditory brainstem of children who are deaf: effects of place and level of bilateral electrical stimulation.
abstract: Bilateral cochlear implants (CIs) might promote development of binaural hearing required to localize sound sources and hear speech in noise for children who are deaf. These hearing skills improve in children implanted bilaterally but remain poorer than normal. We thus questioned whether the deaf and immature human auditory system is able to integrate input delivered from bilateral CIs. Using electrophysiological measures of brainstem activity that include the Binaural Difference (BD), a measure of binaural processing, we showed that a period of unilateral deprivation before bilateral CI use prolonged response latencies but that amplitudes were not significantly affected. Tonotopic organization was retained to some extent as evidenced by an elimination of the BD with large mismatches in place of stimulation between the two CIs. Smaller place mismatches did not affect BD latency or amplitude, indicating that the tonotopic organization of the auditory brainstem is underdeveloped and/or not well used by CI stimulation. Finally, BD amplitudes decreased when the intensity of bilateral stimulation became weighted to one side and this corresponded to a perceptual shift of sound away from midline toward the side of increased intensity. In summary, bilateral CI stimulation is processed by the developing human auditory brainstem leading to perceptual changes in sound location and potentially improving hearing for children who are deaf.
authors.affiliation: Archie's Cochlear Implant Laboratory, Hospital for Sick Children, Toronto, Ontario, Canada. karen.gordon@utoronto.ca
authors.forename: Karen A
authors.initials: KA
authors.lastname: Gordon
authors.forename: Claire
authors.initials: C
authors.lastname: Salloum
authors.forename: Gurvinder S
authors.initials: GS
authors.lastname: Toor
authors.forename: Richard
authors.initials: R
authors.lastname: van Hoesel
authors.forename: Blake C
authors.initials: BC
authors.lastname: Papsin
mesh_terms: D000161:Acoustic Stimulation; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D019929:Cochlear Implantation / Q000379:methods; D003265:Contingent Negative Variation / Q000502:physiology; D003638:Deafness / Q000503:physiopathology*; D004558:Electric Stimulation / Q000379:methods; D004569:Electroencephalography; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D007223:Infant; D008297:Male; D011571:Psychoacoustics; D013017:Sound Localization / Q000502:physiology*; D013067:Speech Perception / Q000502:physiology*