title: Lack of association of ACP1 gene with inflammatory bowel disease: a case-control study.
abstract: The red cell acid phosphatease (ACP1) gene, which encodes a low molecular weight phosphotyrosine phosphatase (LMW-PTP), has been suggested as a common genetic factor of autoimmunity. In the present study, we aimed to investigate the possible influence of ACP1 polymorphisms in the susceptibility of inflammatory bowel disease (IBD). A total of 1271 IBD Spanish patients [720 Crohn's disease (CD) and 551 ulcerative colitis (UC)] and 1877 healthy subjects were included. Four single-nucleotide polymorphisms (SNPs), rs10167992, rs11553742, rs7576247 and rs3828329, were genotyped using TaqMan SNP genotyping assays. Common ACP1 alleles (i.e. ACP1*A, ACP1*B and ACP1*C) were determined by two of these SNPs. After the analysis, no evidence of association of the ACP1 genetic variants was found with CD or UC. Therefore, our results suggest that the ACP1 gene may not play a relevant role in the development of IBD.
authors.affiliation: Instituto de Parasitología y Biomedicina López-Neyra, IPBLN-CSIC, Armilla, Granada, Spain. mteruel@ipb.csic.es
authors.forename: M
authors.initials: M
authors.lastname: Teruel
authors.forename: J E
authors.initials: JE
authors.lastname: Martin
authors.forename: M
authors.initials: M
authors.lastname: Gómez-García
authors.forename: C
authors.initials: C
authors.lastname: Cardeña
authors.forename: L
authors.initials: L
authors.lastname: Rodrigo
authors.forename: A
authors.initials: A
authors.lastname: Nieto
authors.forename: G
authors.initials: G
authors.lastname: Alcain
authors.forename: I
authors.initials: I
authors.lastname: Cueto
authors.forename: M A
authors.initials: MA
authors.lastname: López-Nevot
authors.forename: J
authors.initials: J
authors.lastname: Martin
mesh_terms: D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000235:genetics*; D008297:Male; D020641:Polymorphism, Single Nucleotide; D017027:Protein Tyrosine Phosphatases / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D013030:Spain
chemical_list: D011518:Proto-Oncogene Proteins; C490429:ACP1 protein, human; D017027:Protein Tyrosine Phosphatases