title: Pharmacokinetics and disposition of nanomedicine using biodegradable PEG/PCL polymers as drug carriers.
abstract: Micelles assembled from amphiphilic poly(ethylene glycol)/poly(-caprolactone) (PEG/PCL) copolymers are promised as safe and effective drug delivery systems. They offer the potential to achieve high solubility of hydrophobic drugs, long blood circulation time and effective delivery to target organs. These advantages contribute to their application as vehicles of a broad variation of therapeutic compounds. In this review, we discussed the safety of the copolymers, release behavior of PEG/PCL micelles in vitro, and pharmacokinetic profiles referring to the optimized fate in vascular system and targeting biodistribution.
authors.affiliation: State Key Lab of Biotherapy, West China Hospital, Sichuan University, Chengdu, PR China.
authors.forename: YuJun
authors.initials: Y
authors.lastname: Wang
authors.forename: MaLing
authors.initials: M
authors.lastname: Gou
authors.forename: ChangYang
authors.initials: C
authors.lastname: Gong
authors.forename: Cheng
authors.initials: C
authors.lastname: Wang
authors.forename: ZhiYong
authors.initials: Z
authors.lastname: Qian
authors.forename: Yun Feng
authors.initials: YF
authors.lastname: Lin
authors.forename: Feng
authors.initials: F
authors.lastname: Luo
mesh_terms: D000818:Animals; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000493:pharmacokinetics* / Q000633:toxicity; D006801:Humans; D008823:Micelles; D050997:Nanomedicine; D011091:Polyesters / Q000493:pharmacokinetics* / Q000633:toxicity; D011092:Polyethylene Glycols / Q000493:pharmacokinetics* / Q000633:toxicity
chemical_list: D003692:Delayed-Action Preparations; D004337:Drug Carriers; D008823:Micelles; D011091:Polyesters; C016240:polycaprolactone; D011092:Polyethylene Glycols