title: Scolicidal effects of Olea europaea and Satureja khuzestanica extracts on protoscolices of hydatid cysts.
abstract: Treatment of hydatid disease is mainly surgical, with medical treatment being reserved as a coadjuvant treatment. Use of effective scolicidal agents during surgery of cystic echinococcosis is essential to reduce the recurrence rate. The goal of this study was to evaluate the in vitro scolicidal effects of hydroalcoholic extracts of Satureja khuzestanica leaves and aqueous extracts of Olea europaea leaves on hydatid cyst protoscolices. Echinococcus granulosus protoscolices were collected from the liver of sheep infected with the hydatid cyst. Various concentrations of plant extracts were used in different exposure times for viability assay of protoscolices. Among the olive leaf extracts tested, 0.1% and 0.01% concentrations had strong scolicidal effects in 120 min. S. khuzestanica 0.1% had very strong scolicidal effects in 30, 60, and 120 min of exposure times and the mortality rate decreased with the lower concentration. The finding have shown that the scolicidal activity of S. khuzestanica against cystic echinococosis protoscolices were more effective, while the O. europaea extract showed less effects.
authors.affiliation: Division of Parasitology, Razi Herbal Medicines Research Center, Lorestan University of Medical Sciences, Khorram Abad, Iran. zibaeim@sums.ac.ir
authors.forename: Mohammad
authors.initials: M
authors.lastname: Zibaei
authors.forename: Amanallah
authors.initials: A
authors.lastname: Sarlak
authors.forename: Bahram
authors.initials: B
authors.lastname: Delfan
authors.forename: Behrouz
authors.initials: B
authors.lastname: Ezatpour
authors.forename: Alireza
authors.initials: A
authors.lastname: Azargoon
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004443:Echinococcosis / Q000188:drug therapy / Q000469:parasitology*; D048209:Echinococcus granulosus / Q000187:drug effects / Q000502:physiology; D006801:Humans; D031658:Olea / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D031362:Satureja / Q000737:chemistry*
chemical_list: D000871:Anthelmintics; D010936:Plant Extracts