title: Gómez-López-Hernández syndrome: another consideration in corneal neurotrophic ulcers.
abstract: OBJECTIVE
  To report a case of a Gómez-López-Hernández syndrome (GLHS) variant with corneal neurotrophic ulcer.
  
  
  METHODS
  Case report and review of the literature.
  
  
  RESULTS
  A 6-year-old child presented with watering in the right eye for 3 days without ocular inflammation or pain. He had a peculiar facial phenotype and scalp alopecia in the right side. Slit-lamp examination showed an epithelial defect in the right eye and a corneal scar around the defect. Belmonte noncontact esthesiometry showed reduced corneal mechanosensory and thermal sensitivity. In vivo confocal microscopy revealed the absence of innervation in the right cornea. There was also an evident insensitivity in the alopecic region. Despite normal magnetic resonance imaging, the phenotypic manifestations along with ocular features suggested the diagnosis of a GLHS variant.
  
  
  CONCLUSIONS
  Patients with GLHS remain asymptomatic even when they develop a corneal ulcer. Parents should be advised regarding the susceptibility of an affected child to the development of corneal lesions and the importance of regular follow-up and prompt treatment to prevent vision-threatening abnormalities.
authors.affiliation: Hospital Clínico Universitario de Valladolid, Valladolid, Spain. salva_pastor@hotmail.com
authors.forename: Salvador
authors.initials: S
authors.lastname: Pastor-Idoate
authors.forename: Ester
authors.initials: E
authors.lastname: Carreño
authors.forename: Marisa
authors.initials: M
authors.lastname: Tesón
authors.forename: José M
authors.initials: JM
authors.lastname: Herreras
mesh_terms: D000015:Abnormalities, Multiple / Q000175:diagnosis / Q000209:etiology*; D000505:Alopecia / Q000175:diagnosis / Q000209:etiology*; D000506:Alopecia Areata / Q000175:diagnosis / Q000209:etiology; D002531:Cerebellum / Q000002:abnormalities; D002648:Child; D003315:Cornea / Q000294:innervation*; D003320:Corneal Ulcer / Q000175:diagnosis / Q000209:etiology*; D003389:Cranial Nerve Diseases / Q000175:diagnosis / Q000209:etiology*; D019465:Craniofacial Abnormalities / Q000175:diagnosis / Q000209:etiology*; D006130:Growth Disorders / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D018613:Microscopy, Confocal; D020752:Neurocutaneous Syndromes / Q000175:diagnosis / Q000209:etiology*; D009882:Ophthalmic Nerve / Q000002:abnormalities*; D012249:Rhombencephalon