title: The journey of resveratrol from yeast to human.
abstract: The natural polyphenolic compound resveratrol was first discovered in the 1940s. In the recent years, this compound received renewed interest as several findings implicated resveratrol as a potent SIRT1 activator capable of mimicking the effects of calorie restriction, and regulating longevity in lower organisms. Given the worldwide increase in age-related metabolic diseases the beneficial effects of resveratrol on metabolism and healthy aging in humans are currently a topic of intense investigation.
authors.affiliation: Top Institute Food and Nutrition (TIFN), Wageningen, The Netherlands.
authors.forename: Silvie
authors.initials: S
authors.lastname: Timmers
authors.forename: Johan
authors.initials: J
authors.lastname: Auwerx
authors.forename: Patrick
authors.initials: P
authors.lastname: Schrauwen
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D031204:Caloric Restriction; D004734:Energy Metabolism / Q000187:drug effects*; D004789:Enzyme Activation; D020536:Enzyme Activators / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D019317:Evidence-Based Medicine; D005656:Fungal Proteins / Q000378:metabolism; D006801:Humans; D010726:Phosphodiesterase Inhibitors / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D000077185:Resveratrol; D056564:Sirtuin 1 / Q000378:metabolism; D013267:Stilbenes / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D015003:Yeasts / Q000187:drug effects* / Q000201:enzymology
chemical_list: D020536:Enzyme Activators; D005656:Fungal Proteins; D010726:Phosphodiesterase Inhibitors; D013267:Stilbenes; C447939:SIRT1 protein, human; D056564:Sirtuin 1; D000077185:Resveratrol