title: Bone marrow stem cell abnormality and diabetic complications.
abstract: Long-lasting diabetes impairs the function of multiple organs, which consists of degeneration of various tissues with increasing apoptosis of target cells. Recently, we found that hyperglycemia induced the appearance of abnormal cells in the bone marrow and cell fusion between bone marrow-derived cells and hepatocytes, peripheral neural cells, or renal tubular cells occurred in diabetic animals. Fused cells in these organs expressed TNFα, and accelerated apoptosis, suggesting that these events might be a cause of diabetic complications. In this review, we propose a new concept that bone marrow stem cell abnormality causes diabetic complications, and this concept might provide new strategies for treatment of diabetes-associated tissue damage.
authors.affiliation: Department of Anatomy, Sapporo Medical University School of Medicine, Japan. fujimiya@sapmed.ac.jp
authors.forename: Mineko
authors.initials: M
authors.lastname: Fujimiya
authors.forename: Kanna
authors.initials: K
authors.lastname: Nagaishi
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Yamashita
authors.forename: Koji
authors.initials: K
authors.lastname: Ataka
mesh_terms: D017209:Apoptosis; D002459:Cell Fusion; D048909:Diabetes Complications / Q000378:metabolism / Q000473:pathology*; D006412:Hematopoietic Stem Cells / Q000378:metabolism / Q000473:pathology*; D022781:Hepatocytes / Q000473:pathology / Q000502:physiology; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology / Q000378:metabolism / Q000473:pathology*; D007684:Kidney Tubules / Q000378:metabolism / Q000473:pathology; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D010525:Peripheral Nerves / Q000473:pathology; D055153:Stem Cell Niche / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D014409:Tumor Necrosis Factor-alpha