title: Influence of melatonin or its antagonism on alcohol consumption in ethanol drinking rats: a behavioral and in vivo voltammetric study.
abstract: Melatonin, an indoleamine hormone synthesized in the pinealocytes, has been implicated as influencing the intake of alcohol in rats. It has been shown that this hormone is voltammetrically electroactive at the surface of pretreated carbon fiber microelectrodes in vitro and in vivo, in rat cerebral melatonergic regions such the pineal gland. The aim of this work consisted in the study of the influence of melatonin on spontaneously ethanol drinking or ethanol avoiding rats selected throughout a free choice two bottle test. It appeared that only the water preferring rats were affected by treatment with the hormone and that in vivo voltammetric related levels of melatonin were higher in the pineal gland of ethanol drinking rats versus water preferring rats. In addition, when treated with the melatonin antagonist GR128107 ethanol drinking rats significantly reduced the spontaneous consumption of alcohol.
authors.affiliation: Biology Dept, Neurosciences CEDD GlaxoSmithKline, Medicines Research Centre, Verona, Italy. francesco.m.crespi@gsk.com
authors.forename: Francesco
authors.initials: F
authors.lastname: Crespi
mesh_terms: D000428:Alcohol Drinking; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004327:Drinking Behavior / Q000187:drug effects*; D000431:Ethanol; D007211:Indoles / Q000494:pharmacology; D008297:Male; D008550:Melatonin / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D010880:Piperidines / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
chemical_list: C119151:GR 128107; D007211:Indoles; D010880:Piperidines; D000431:Ethanol; D008550:Melatonin