title: A model study for constructing the DEF-benzoxocin ring system of menogaril and nogalamycin via a reductive Heck cyclization.
abstract: A novel reductive Heck cyclization approach was developed in order to construct a model DEF-benzoxocin ring system that is present in nogalamycin, menogaril, and related anthracycline antitumor antibiotics.
authors.affiliation: Department of Chemistry, 800 East Kirkwood Avenue, Bloomington, Indiana 47405-7102, USA.
authors.forename: Ruogu
authors.initials: R
authors.lastname: Peng
authors.forename: Michael S
authors.initials: MS
authors.lastname: VanNieuwenhze
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis* / Q000737:chemistry; D003500:Cyclization; D017290:Menogaril / Q000138:chemical synthesis* / Q000737:chemistry; D008956:Models, Chemical; D015394:Molecular Structure; D009621:Nogalamycin / Q000138:chemical synthesis* / Q000737:chemistry; D013302:Streptomyces / Q000737:chemistry
chemical_list: D000903:Antibiotics, Antineoplastic; D017290:Menogaril; D009621:Nogalamycin