title: Tuberculosis: from molecular pathogenesis to effective drug carrier design.
abstract: In the past two decades, tuberculosis has gone from being a forgotten disease to a modern and recrudescent pathology. Tuberculosis is a curable infection and most of the negative therapeutic outcomes are related to poor patient compliance, which could be solved by new drug delivery approaches. By using such approaches the technological drawbacks of the currently used therapeutic agents could be addressed. In addition, optimum effectiveness of the drug by targeting the infection reservoirs could be achieved. In this article we compile the general physiological aspects of the infection along with new research updates especially on novel carriers used in the prevention of tuberculosis which might enhance therapeutic efficacy and patient compliance.
authors.affiliation: Department of Pharmaceutical Sciences, Dr. H S Gour University, Sagar 470 003, MP, India.
authors.forename: Devyani
authors.initials: D
authors.lastname: Dube
authors.forename: Govind P
authors.initials: GP
authors.lastname: Agrawal
authors.forename: Suresh P
authors.initials: SP
authors.lastname: Vyas
mesh_terms: D000818:Animals; D000995:Antitubercular Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004337:Drug Carriers / Q000737:chemistry*; D015195:Drug Design; D006801:Humans; D008823:Micelles; D053758:Nanoparticles; D011108:Polymers / Q000737:chemistry*; D014376:Tuberculosis / Q000188:drug therapy* / Q000382:microbiology*
chemical_list: D000995:Antitubercular Agents; D004337:Drug Carriers; D008823:Micelles; D011108:Polymers