title: A histopathologic study of fatal paediatric cerebral malaria caused by mixed Plasmodium falciparum/Plasmodium vivax infections.
abstract: Microvascular sequestration of Plasmodium falciparum underlies cerebral malaria. Despite suggestive ex vivo evidence, this phenomenon has not been convincingly demonstrated in coma complicating Plasmodium vivax malaria. Severely-ill Papua New Guinean children with mixed P. falciparum/P. vivax infections are more likely to develop cerebral malaria and die than those with P. falciparum alone, possibly reflecting P. vivax sequestration. Nested PCR was performed on post mortem brain tissue from three such children dying from cerebral malaria due to mixed-species infections. No P. vivax DNA was detected. These findings do not support the hypothesis that P. vivax sequestration occurs in human brain.
authors.affiliation: School of Medicine and Pharmacology, University of Western Australia, Fremantle Hospital, PO Box 480, Fremantle 6959, Western Australia, Australia.
authors.forename: Laurens
authors.initials: L
authors.lastname: Manning
authors.forename: Anna
authors.initials: A
authors.lastname: Rosanas-Urgell
authors.forename: Moses
authors.initials: M
authors.lastname: Laman
authors.forename: Henry
authors.initials: H
authors.lastname: Edoni
authors.forename: Catriona
authors.initials: C
authors.lastname: McLean
authors.forename: Ivo
authors.initials: I
authors.lastname: Mueller
authors.forename: Peter
authors.initials: P
authors.lastname: Siba
authors.forename: Timothy M E
authors.initials: TM
authors.lastname: Davis
mesh_terms: D000818:Animals; D001921:Brain / Q000469:parasitology; D002648:Child; D002675:Child, Preschool; D060085:Coinfection / Q000175:diagnosis / Q000469:parasitology* / Q000473:pathology; D003128:Coma / Q000209:etiology; D016054:DNA, Protozoan / Q000235:genetics; D005260:Female; D006801:Humans; D016779:Malaria, Cerebral / Q000150:complications / Q000175:diagnosis* / Q000469:parasitology / Q000473:pathology*; D016778:Malaria, Falciparum / Q000175:diagnosis* / Q000469:parasitology / Q000473:pathology*; D016780:Malaria, Vivax / Q000175:diagnosis* / Q000469:parasitology / Q000473:pathology*; D008297:Male; D010219:Papua New Guinea; D010963:Plasmodium falciparum / Q000302:isolation & purification; D010966:Plasmodium vivax / Q000302:isolation & purification; D016133:Polymerase Chain Reaction
chemical_list: D016054:DNA, Protozoan