title: [Hormonal and inflammatory biomarkers in a group of overweight and obese women].
abstract: OBJECTIVE
  The aim of this study was to describe the hormonal and inflammatory status of a group of overweight/obese women.
  
  
  METHODS
  The sample studied was a crosssectional cohort of women > 18 years of age, BMI ≥ 25 < 40 kg/m², prior to starting a weight control program. Data collected were: demographic characteristics, blood pressure, anthropometric parameters, physical activity data, and biochemical, hormonal and inflammatory biomarkers.
  
  
  RESULTS
  The study involved 104 women with a mean age of 48.4 ± 9 years and a BMI of 29.8 ± 3.5 kg/m². Some 48% of the women studied were in menopause. Some 8.9% had hyperinsulinemia. The mean ghrelin value was 38.8 ± 33.6 pg/ml; there was no correlation between ghrelin levels and anthropometric and biochemical variables. CRP, leptin, adiponectin, resistin, IL6, IL10, and PAI1 were 3.0 ± 2.7 mg/dl, 36.3 ± 19.5 ng/ml, 8.3 ± 4.5 mg/ml, 24.3 ± 23.2 ng/ml, 51.6 ± 93.6 pg/ml, 10.0 ± 34.2 pg/ml and 22.3 ± 30.6 ng/ml, respectively. Obese patients had significantly higher mean values of resistin and PAI 1 than those who were overweight. These levels correlated significantly with anthropometric and biochemical variables; however, the correlations were weak. Age, menopause or the regular practice of physical activity had no effect on mean values.
  
  
  CONCLUSIONS
  The group of women studied had altered inflammatory biomarkers in relation to people of normal weight. The study shows the inflammatory status of overweight/ obese individuals, and the values obtained may help to establish standard ranges for these markers.
authors.affiliation: Unidad de Nutrición Clínica y Dietética, Hospital Universitario La Paz, IdiPAZ, Madrid, España. vloria@hotmail.com
authors.forename: V
authors.initials: V
authors.lastname: Loria Kohen
authors.forename: C
authors.initials: C
authors.lastname: Gómez Candela
authors.forename: C
authors.initials: C
authors.lastname: Fernández Fernández
authors.forename: L
authors.initials: L
authors.lastname: Zurita Rosa
authors.forename: S
authors.initials: S
authors.lastname: Palma Milla
authors.forename: M
authors.initials: M
authors.lastname: Urbieta
authors.forename: L M
authors.initials: LM
authors.lastname: Bermejo López
mesh_terms: D000328:Adult; D000368:Aged; D000886:Anthropometry; D015415:Biomarkers / Q000097:blood*; D001823:Body Composition / Q000502:physiology; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D003430:Cross-Sectional Studies; D005260:Female; D006728:Hormones / Q000097:blood*; D006801:Humans; D007249:Inflammation / Q000097:blood*; D007333:Insulin Resistance / Q000502:physiology; D008875:Middle Aged; D009752:Nutritional Status; D009765:Obesity / Q000097:blood*; D050177:Overweight / Q000097:blood*
chemical_list: D015415:Biomarkers; D006728:Hormones; D002097:C-Reactive Protein