title: GW501516 acts as an efficient PPARα activator in the mouse liver.
abstract: The peroxisome proliferator-activated receptor (PPAR) subtype specificity of GW501516, a well-known PPARδ-specific agonist, was studied by examining its effects on the expression of endogenous genes in primary hepatocytes and the liver of wild-type and PPARα-null mice. GW501516, like the PPARα-specific agonist Wy14,643, induced the expression of several PPAR target genes in a dose-dependent manner but this action was mostly absent in the cells and liver of PPARα-null mice. Results indicated that GW501516 acts as an efficient PPARα activator in the mouse liver.
authors.affiliation: Department of Biochemistry, Meiji Pharmaceutical University, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Terada
authors.forename: M
authors.initials: M
authors.lastname: Araki
authors.forename: B
authors.initials: B
authors.lastname: Ashibe
authors.forename: K
authors.initials: K
authors.lastname: Motojima