title: Kidney stone erosion by micro scale hydrodynamic cavitation and consequent kidney stone treatment.
abstract: The objective of this study is to reveal the potential of micro scale hydrodynamic bubbly cavitation for the use of kidney stone treatment. Hydrodynamically generated cavitating bubbles were targeted to the surfaces of 18 kidney stone samples made of calcium oxalate, and their destructive effects were exploited in order to remove kidney stones in in vitro experiments. Phosphate buffered saline (PBS) solution was used as the working fluid under bubbly cavitating conditions in a 0.75 cm long micro probe of 147 μm inner diameter at 9790 kPa pressure. The surface of calcium oxalate type kidney stones were exposed to bubbly cavitation at room temperature for 5 to 30 min. The eroded kidney stones were visually analyzed with a high speed CCD camera and using SEM (scanning electron microscopy) techniques. The experiments showed that at a cavitation number of 0.017, hydrodynamic bubbly cavitation device could successfully erode stones with an erosion rate of 0.31 mg/min. It was also observed that the targeted application of the erosion with micro scale hydrodynamic cavitation may even cause the fracture of the kidney stones within a short time of 30 min. The proposed treatment method has proven to be an efficient instrument for destroying kidney stones.
authors.affiliation: Mechatronics Engineering Program, Faculty of Engineering and Natural Sciences, Sabanci University, Orhanli, Tuzla, Istanbul, Turkey. yavuzperk@sabanciuniv.edu
authors.forename: Osman Yavuz
authors.initials: OY
authors.lastname: Perk
authors.forename: Muhsincan
authors.initials: M
authors.lastname: Şeşen
authors.forename: Devrim
authors.initials: D
authors.lastname: Gozuacik
authors.forename: Ali
authors.initials: A
authors.lastname: Koşar
mesh_terms: D002129:Calcium Oxalate; D057446:Hydrodynamics; D007669:Kidney Calculi / Q000628:therapy* / Q000648:ultrastructure; D008855:Microscopy, Electron, Scanning; D010710:Phosphates
chemical_list: D010710:Phosphates; D002129:Calcium Oxalate