title: Apatite formation on nanomaterial calcium phosphate/poly-DL-lactide-co-glycolide in simulated body fluid.
abstract: Simulated body fluid (SBF) is an artificial fluid which has ionic composition and ionic concentration similar to human blood plasma.
  
  
  OBJECTIVE
  This paper compares the interaction between the nanomaterial containing calcium phosphate/poly-dl-lactide-co-glycolide (N-CP/PLGA) and SBF, in order to investigate whether and to what extent inorganic ionic composition of human blood plasma leads to the aforementioned changes in the material.
  
  
  METHODS
  N-CP/PLGA was incubated for 1, 2, 3, and 5 weeks in SBF. The surface of the material was analyzed on SEM-EDS and FTIR spectrometer, while SBF was subjected to pH and electrical conductivity measurement.
  
  
  RESULTS
  Our results indicate that dissolution of the polymer component of the material N-CP/PLGA and precipitation of the material similar to hydroxyapatite on its surface are based on the morphologic changes seen in this material.
  
  
  CONCLUSIONS
  The mechanism of the apatite formation on the bioceramic surface was intensively studied and was considered crucial in designing the new biomaterials. The results obtained in this work indicate that N-CP/PLGA may be a good candidate for application to bone regeneration.
authors.affiliation: Institute of Biology and Human Genetics, Faculty of Medicine, University of Nis, Serbia. marijavukelic@medfak.ni.ac.rs
authors.forename: Marija Ð
authors.initials: MÐ
authors.lastname: Vukelić
authors.forename: Žarko J
authors.initials: ŽJ
authors.lastname: Mitić
authors.forename: Miroslav S
authors.initials: MS
authors.lastname: Miljkovic
authors.forename: Jelena M
authors.initials: JM
authors.lastname: Živković
authors.forename: Nenad L
authors.initials: NL
authors.lastname: Ignjatović
authors.forename: Dragan P
authors.initials: DP
authors.lastname: Uskoković
authors.forename: Jelena Ž
authors.initials: JŽ
authors.lastname: Živanov-Čurlis
authors.forename: Perica J
authors.initials: PJ
authors.lastname: Vasiljevic
authors.forename: Stevo J
authors.initials: SJ
authors.lastname: Najman
mesh_terms: D001031:Apatites / Q000097:blood / Q000737:chemistry*; D004553:Electric Conductivity; D006801:Humans; D006863:Hydrogen-Ion Concentration; D019344:Lactic Acid / Q000097:blood / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D008954:Models, Biological; D049329:Nanostructures / Q000737:chemistry / Q000648:ultrastructure; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D013052:Spectrometry, X-Ray Emission; D013055:Spectrophotometry, Infrared
chemical_list: D001031:Apatites; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid