title: Controlled generation of singlet oxygen by a water-soluble meso-pyrenylporphyrin photosensitizer through interaction with DNA.
abstract: An electron donor-connecting water-soluble porphyrin, meso-(1-pyrenyl)-tris(N-methyl-p-pyridinio)porphyrin, did not demonstrate singlet oxygen generating activity under photo-irradiation. The interaction with DNA successfully recovered the photosensitized singlet oxygen generation by this porphyrin.
authors.affiliation: Department of Basic Engineering (Chemistry), Faculty of Engineering, Shizuoka University, Johoku 3-5-1, Hamamatsu, Shizuoka 432-8561, Japan. tkhirak@ipc.shizuoka.ac.jp
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Hirakawa
authors.forename: Mari
authors.initials: M
authors.lastname: Harada
authors.forename: Shigetoshi
authors.initials: S
authors.lastname: Okazaki
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Nosaka
mesh_terms: D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D008954:Models, Biological; D016877:Oxidants; D017319:Photosensitizing Agents / Q000737:chemistry*; D011166:Porphyrins / Q000737:chemistry* / Q000378:metabolism; D011721:Pyrenes / Q000737:chemistry* / Q000378:metabolism; D026082:Singlet Oxygen; D012995:Solubility; D014867:Water / Q000737:chemistry*
chemical_list: D016877:Oxidants; D017319:Photosensitizing Agents; D011166:Porphyrins; D011721:Pyrenes; D014867:Water; D026082:Singlet Oxygen; D004247:DNA