title: Formation of monoethylglycinexylidide (MEGX) in clinically healthy dogs.
abstract: Liver function tests help to investigate actual liver function. In dogs, only a few tests are available. We evaluated the formation of monoethylglycinexylidide (MEGX) in clinically healthy dogs to assess the usefulness of this liver function test in dogs. Twenty-five healthy dogs were used in this study. The MEGX test was done according to human protocols. The results of our study showed that dogs synthesize MEGX after the administration of lidocaine. There was no age dependence of this test in dogs and no significant difference between measurements obtained at 15 and 30 min after administration of lidocaine. Female dogs had significantly (P < 0.05) higher concentrations of MEGX 15 min after administration. The reference interval for dogs after 15 min is 34 to 79 μg/L and after 30 min 39 to 89 μg/L. In conclusion, the MEGX test may be an additional liver function test in dogs.
authors.affiliation: Institute of Veterinary Medicine, University of Goettingen, Goettingen, Germany. sneuman@gwdg.de
authors.forename: Stephan
authors.initials: S
authors.lastname: Neumann
authors.forename: Meike
authors.initials: M
authors.lastname: Frenz
authors.forename: Frank
authors.initials: F
authors.lastname: Streit
authors.forename: Michael
authors.initials: M
authors.lastname: Oellerich
mesh_terms: D000779:Anesthetics, Local / Q000493:pharmacokinetics; D000818:Animals; D004285:Dogs / Q000502:physiology*; D005260:Female; D008012:Lidocaine / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism / Q000493:pharmacokinetics; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008111:Liver Function Tests / Q000662:veterinary*; D008297:Male
chemical_list: D000779:Anesthetics, Local; D008012:Lidocaine; C001173:monoethylglycinexylidide