title: Synthesis of the bridging framework of phragmalin-type limonoids.
abstract: An efficient synthesis of the octahydro-1H-2,4-methanoindene core of phragmalin-type limonoids, such as xyloccensins O and P, is reported. The success of the synthetic route is predicated on the use of network analysis in the retrosynthetic analysis and a Diels-Alder reaction for the synthesis of a key hydrindanone derivative.
authors.affiliation: Department of Chemistry, University of California, Berkeley, California 94720, USA.
authors.forename: Terry P
authors.initials: TP
authors.lastname: Lebold
authors.forename: Gary M
authors.initials: GM
authors.lastname: Gallego
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Marth
authors.forename: Richmond
authors.initials: R
authors.lastname: Sarpong
mesh_terms: D003500:Cyclization; D036701:Limonins / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure
chemical_list: D036701:Limonins; C489298:xyloccensin O; C489299:xyloccensin P