title: Clinical-pathological features of gastrointestinal stromal tumors presenting associated with other neoplasms: a brief report.
abstract: OBJECTIVE
  Over the past 10 years, few authors reported the synchronous detection of gastrointestinal stromal tumors (GISTs) and other neoplasms in the 9-33% of GISTs series. The primary aim of the present study was of investigating the features of GISTs detected in patients with other malignancies.
  
  
  METHODS
  From 1999 to 2010 the GISTs detected at surgical exploration or preoperative assessment for other malignancies plus primary-GISTs, were recorded and reviewed.
  
  
  RESULTS
  All synchronous GISTs were positive for kit/CD34, resulting smaller in size, with a lower mitotic index and occurring in elderly patients, comparing with primary-GISTs (P<0.05). Moreover a prevalence of males and of lower-risk classifications were noted, not reaching, however, a statistical value.
  
  
  CONCLUSIONS
  According with our findings, the synchronous GISTs are mainly asymptomatic/incidentally detected and display some of the low malignant features; we recommend, however, the surgical excision of GISTs occurring in patients with other malignancies in order to define the histology and risk features and since it might result in an incorrect management if misdiagnosed as a metastases.
authors.affiliation: Surgical and Medical Department of Clinical Sciences, La Sapienza University, Rome, Italy. laura.lorenzon@uniroma1.it
authors.forename: L
authors.initials: L
authors.lastname: Lorenzon
authors.forename: V
authors.initials: V
authors.lastname: Ziparo
authors.forename: D
authors.initials: D
authors.lastname: Cavaniglia
authors.forename: E
authors.initials: E
authors.lastname: Pilozzi
authors.forename: E
authors.initials: E
authors.lastname: Iannicelli
authors.forename: S
authors.initials: S
authors.lastname: Caterino
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D046152:Gastrointestinal Stromal Tumors / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D012189:Retrospective Studies