title: Netrin-1 improves spatial memory and synaptic plasticity impairment following global ischemia in the rat.
abstract: Cerebral ischemia, which is the second and most common cause of mortality, affects millions of individuals worldwide. The present study was performed to investigate whether intrahippocampal administration of netrin-1 could improve spatial memory impairment in radial arm maze task and restore long-term potentiation (LTP) in 4-vessel occlusion model of global ischemia. The results showed that intrahippocampal infusion of nerin-1 24 h after ischemia (at both doses of 400 and 800 ng) significantly ameliorated spatial memory impairment and at a dose of 800 ng was capable to improve synaptic dysfunction as observed by recovery of population spike component of basal evoked potential and LTP through enhancement of excitability and normalization of paired pulse response. Taken together, the present study shows that netrin-1 dose-dependently ameliorates spatial memory impairment and improves synaptic dysfunction as observed by recovery of population spike component of basal evoked potential and LTP in rats with global ischemia.
authors.affiliation: Dept. Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Mahnaz
authors.initials: M
authors.lastname: Bayat
authors.forename: Tourandokht
authors.initials: T
authors.lastname: Baluchnejadmojarad
authors.forename: Mehrdad
authors.initials: M
authors.lastname: Roghani
authors.forename: Fatemeh
authors.initials: F
authors.lastname: Goshadrou
authors.forename: Abdolaziz
authors.initials: A
authors.lastname: Ronaghi
authors.forename: Mehdi
authors.initials: M
authors.lastname: Mehdizadeh
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000503:physiopathology*; D004305:Dose-Response Relationship, Drug; D017774:Long-Term Potentiation / Q000187:drug effects*; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D008568:Memory / Q000187:drug effects*; D009414:Nerve Growth Factors / Q000494:pharmacology*; D000075388:Netrin-1; D051381:Rats; D017208:Rats, Wistar; D013569:Synapses / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects; D025521:Tumor Suppressor Proteins / Q000494:pharmacology*
chemical_list: D009414:Nerve Growth Factors; C000617354:Ntn1 protein, rat; D025521:Tumor Suppressor Proteins; D000075388:Netrin-1