title: Correlation of clinical outcomes with β-glucan levels in patients with invasive candidiasis.
abstract: The correlation of β-glucan (BG) levels with clinical outcomes in invasive candidiasis (IC) remains unknown. Patients with proven IC were followed prospectively from diagnosis to outcome with twice-weekly serum BG sampling. Correlation of BG with clinical outcome was assessed in each patient. BG levels tend to decrease in successfully treated patients and increase in treatment failures. BG levels may be useful as surrogates for outcome evaluation of IC.
authors.affiliation: Laboratory of Mycology Research, Division of Infectious Diseases, University of Texas Health Science Center at Houston, Houston, Texas, USA.
authors.forename: Charles R
authors.initials: CR
authors.lastname: Sims
authors.forename: Siraya
authors.initials: S
authors.lastname: Jaijakul
authors.forename: John
authors.initials: J
authors.lastname: Mohr
authors.forename: Jose
authors.initials: J
authors.lastname: Rodriguez
authors.forename: Malcolm
authors.initials: M
authors.lastname: Finkelman
authors.forename: Luis
authors.initials: L
authors.lastname: Ostrosky-Zeichner
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000008:administration & dosage; D058365:Candidiasis, Invasive / Q000188:drug therapy / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D044967:Serum / Q000737:chemistry; D016896:Treatment Outcome; D055815:Young Adult; D047071:beta-Glucans / Q000097:blood*
chemical_list: D000935:Antifungal Agents; D047071:beta-Glucans