title: A randomized, placebo-controlled study of pregabalin for postoperative pain intensity after laparoscopic cholecystectomy.
abstract: OBJECTIVE
  To determine the efficacy of two different doses (150 mg and 300 mg) of preoperative pregabalin on pain relief and total opioid consumption after laparoscopic cholecystectomy.
  
  
  METHODS
  Prospective, randomized, placebo-controlled, double-blinded study.
  
  
  METHODS
  Training and research hospital.
  
  
  METHODS
  90 adult, ASA physical status 1 and 2 patients.
  
  
  METHODS
  Patients were randomly assigned to three groups to receive orally one hour before surgery, a placebo (Group 1), pregabalin 150 mg (Group 2), or pregabalin 300 mg (Group 3). Patients were observed for pregabalin side effects, somnolence via Ramsay Sedation Scale, dizziness, confusion, and ataxia.
  
  
  METHODS
  In the operating room, heart rate and noninvasive systolic and diastolic blood pressures were measured. Visual analog scale (VAS), Ramsay Sedation Scale, and Aldrete scores were also recorded on arrival at the Postanesthesia Care Unit (time 0), 15, 30, 60, 120 minutes and 3, 4, 6, 8, 10, 12 and 24 hours after surgery. Additional doses of drugs (fentanyl and/or metoclopramide) were also recorded.
  
  
  RESULTS
  Preemptive pregabalin decreased pain scores and postoperative fentanyl consumption in patients after laparoscopic cholecystectomy in a dose-dependent manner. There were no differences between the groups in side effects.
  
  
  CONCLUSIONS
  Preoperative pregabalin may be a useful analgesic for patients after laparoscopic cholecystectomy, as it lowers pain intensity and opiod consumption, and does not increase the frequency of side effects.
authors.affiliation: Department of Anesthesiology and Reanimation, Türkiye Yüksek dIhtisas Education and Research Hospital, Sıhhıye 06100, Ankara, Turkey.
authors.forename: Fatih
authors.initials: F
authors.lastname: Balaban
authors.forename: Seyhan
authors.initials: S
authors.lastname: Yağar
authors.forename: Ayşegül
authors.initials: A
authors.lastname: Özgök
authors.forename: Mihrican
authors.initials: M
authors.lastname: Koç
authors.forename: Hayriye
authors.initials: H
authors.lastname: Güllapoğlu
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000700:Analgesics / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000627:therapeutic use; D017081:Cholecystectomy, Laparoscopic / Q000379:methods*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*; D000069583:Pregabalin; D011446:Prospective Studies; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000700:Analgesics; D000701:Analgesics, Opioid; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid; D005283:Fentanyl