title: Biotransformation of gambogenic acid by Chaetomium globosum CICC 2445.
abstract: Microbial transformation of gambogenic acid (1), a caged polyprenylated xanthone isolated from the resin of Garcinia hanburyi, was carried out with Chaetomium globosum CICC 2445, after screening forty-six strains of filamentous fungi. A new caged polyprenylated xanthone, 16,17-dihydroxygambogenic acid (2), was specifically obtained, as a result of hydroxylation at C-16, and C-17. Its structure was elucidated on the basis of spectroscopic methods. The cytotoxicity of compounds 1 and 2 against HeLa tumor cell line was evaluated, with both of them being modestly active.
authors.affiliation: Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
authors.forename: Si-Jia
authors.initials: SJ
authors.lastname: Tao
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.forename: Xing
authors.initials: X
authors.lastname: Zhang
authors.forename: Shu-Hong
authors.initials: SH
authors.lastname: Guan
authors.forename: De-An
authors.initials: DA
authors.lastname: Guo
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D002597:Chaetomium / Q000378:metabolism*; D006367:HeLa Cells; D006801:Humans; D015394:Molecular Structure; D013729:Terpenes / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D014966:Xanthenes; D044004:Xanthones / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*
chemical_list: C571556:16,17-dihydroxygambogenic acid; D000972:Antineoplastic Agents, Phytogenic; D013729:Terpenes; D014966:Xanthenes; D044004:Xanthones; C045863:neo-gambogic acid