title: Periodontal status and post-transplantation complications following intensive periodontal treatment in patients underwent allogenic hematopoietic stem cell transplantation conditioned with myeloablative regimen.
abstract: OBJECTIVE
  Evaluation of the periodontal status is necessary prior to management with high-dose chemotherapy before hematopoietic stem cell therapy (HSCT). During medical therapy, pre-existing periodontal conditions may exacerbate and cause local and systemic complications. When possible, maximal oral health should be achieved prior to engraftment. In this study, we aimed to determine the alterations occurred in the periodontal status of the patients after periodontal treatment and allogenic HSCT and evaluate the effect of intensive periodontal approach on the short-term complications of HSCT.
  
  
  METHODS
  The alterations occurred in the periodontal tissues 3-4 weeks after periodontal treatment and after HSCT periods of 3 months for 29 patients treated with full-mouth periodontal treatment completed in 24 h in addition to eradication of dental foci, and oral hygiene status were evaluated using pocket depth measurements, presence of bleeding on probing and plaque and gingival indices. The incidence and severity of acute graft-versus-host disease (GVHD) and oral mucositis (OM) were recorded. Duration of engraftment period and the episode of febrile neutropenia were also evaluated.
  
  
  RESULTS
  There were significant improvements in periodontal status after periodontal treatment (P<0.001). There were 14 (48.3%) patients without acute GVHD and 17 (58.6%) patients with no sign of OM. The majority of OM was at grade II level. There was a negative relation that exists between the percentage of BOP (+) sites and presence of OM (r=-0.518, P<0.05).
  
  
  CONCLUSIONS
  Together with a significant reduction in gingival inflammation and maintenance of the improvement in periodontal health, remarkable decrease in the incidence and severity of OM were observed.
authors.affiliation: Department of Periodontology, Ankara University, Ankara, Turkey. cagurgan@yahoo.com
authors.forename: C A
authors.initials: CA
authors.lastname: Gürgan
authors.forename: M
authors.initials: M
authors.lastname: Özcan
authors.forename: Ö
authors.initials: Ö
authors.lastname: Karakuş
authors.forename: G
authors.initials: G
authors.lastname: Zincircioğlu
authors.forename: M
authors.initials: M
authors.lastname: Arat
authors.forename: E
authors.initials: E
authors.lastname: Soydan
authors.forename: P
authors.initials: P
authors.lastname: Topcuoglu
authors.forename: G
authors.initials: G
authors.lastname: Gürman
authors.forename: H S
authors.initials: HS
authors.lastname: Bostancı
mesh_terms: D000328:Adult; D003774:Dental Plaque Index; D003777:Dental Prophylaxis; D005260:Female; D005500:Follow-Up Studies; D005884:Gingival Hemorrhage / Q000145:classification; D006086:Graft vs Host Disease / Q000209:etiology; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000601:surgery; D008297:Male; D008875:Middle Aged; D019653:Myeloablative Agonists / Q000627:therapeutic use*; D009503:Neutropenia / Q000209:etiology; D009911:Oral Hygiene Index; D057747:Periodontal Debridement; D010510:Periodontal Diseases / Q000628:therapy*; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000145:classification; D011183:Postoperative Complications; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000601:surgery; D013280:Stomatitis / Q000209:etiology; D014081:Tooth Extraction; D019172:Transplantation Conditioning / Q000379:methods*; D014184:Transplantation, Homologous; D055815:Young Adult
chemical_list: D019653:Myeloablative Agonists