title: [Expressions of BNP and NPR-A in rat models of chronic nonbacterial prostatitis and their significance].
abstract: OBJECTIVE
  To investigate the expressions of brain natriuretic peptide (BNP) and natriuretic peptide receptor (NPR-A) in the cord dorsal horn ganglion (DRG) of rat models of chronic nonbacterial prostatitis (CNP) and the relation of BNP and NPR-A with CNP-induced chronic pain.
  
  
  METHODS
  We established CNP models in 30 healthy clean SD rats using Freund's complete adjuvant, and included another 10 in a sham-operation group. The prostate tissues were subjected to HE staining, and the expressions of BNP and NPR-A in the L5-S2 DRGs were detected by real-time PCR.
  
  
  RESULTS
  Higher degree of inflammation was related to longer modeling time. At 3, 7 and 10 days, the expressions of BNP in the CNP models were 2.16 +/- 0.35, 1.61 +/- 0.21 and 1.32 +/- 0.36, and those of NPR-A were 2.75 +/- 0.06, 2.15 +/- 0.15 and 1.04 +/- 0.13, respectively, significantly higher at 3 and 7 days as compared with the sham-operation group (P<0.05), but with no statistically significant difference at 10 days.
  
  
  CONCLUSIONS
  BNP and NPR-A are expressed in the L5-S2 DRGs of SD rats and their expressions can be upregulated by CNP. BNP and NPR-A may be involved in the mechanisms of CNP-induced pain.
authors.affiliation: Department of Urology, The First Hospital Affiliated to Nanchnag University, Nanchang, Jiangxi 330006, China. 33571473@qq.com
authors.forename: Wen-Jie
authors.initials: WJ
authors.lastname: Xie
authors.forename: Ting
authors.initials: T
authors.lastname: Sun
authors.forename: Xiao-Rong
authors.initials: XR
authors.lastname: Yang
authors.forename: Ming
authors.initials: M
authors.lastname: Ma
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005727:Ganglia, Spinal / Q000378:metabolism; D008297:Male; D020097:Natriuretic Peptide, Brain / Q000378:metabolism*; D011472:Prostatitis / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017461:Receptors, Atrial Natriuretic Factor / Q000378:metabolism*
chemical_list: D020097:Natriuretic Peptide, Brain; D017461:Receptors, Atrial Natriuretic Factor