title: The effect of practice on the recall of salient information in obsessive-compulsive disorder.
abstract: Deficits in memory and cognitive inhibition have been proposed as underlying mechanisms of obsessive-compulsive disorder (OCD). To test this hypothesis, an emotional variant of the retrieval-induced forgetting (RIF) paradigm was constructed which investigates whether repeated retrieval of previously learned material (Rp+) leads to enhanced forgetting of related but nonretrieved material (Rp-) in comparison to unrelated material (NRp). Paradigm (involving OCD-relevant, neutral and negative material) was presented to 21 participants with OCD and 22 healthy controls. To compare personally relevant stimuli across groups, salience ratings of the material were included. RIF was not reduced in OCD per se. Tentative evidence was found for a weakened RIF effect for personally salient OCD-relevant material in OCD patients in comparison to healthy controls.
authors.affiliation: University Medical Center Hamburg-Eppendorf, Department of Psychiatry and Psychotherapy, Martinistr. 52, 20246 Hamburg, Germany. l.jelinek@uke.uni-hamburg.de
authors.forename: Lena
authors.initials: L
authors.lastname: Jelinek
authors.forename: Liz
authors.initials: L
authors.lastname: Rietschel
authors.forename: Michael
authors.initials: M
authors.lastname: Kellner
authors.forename: Christoph
authors.initials: C
authors.lastname: Muhtz
authors.forename: Steffen
authors.initials: S
authors.lastname: Moritz
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D008569:Memory Disorders / Q000209:etiology* / Q000523:psychology / Q000534:rehabilitation*; D011939:Mental Recall / Q000502:physiology*; D009483:Neuropsychological Tests; D009771:Obsessive-Compulsive Disorder / Q000150:complications*; D011214:Practice, Psychological; D011569:Psychiatric Status Rating Scales; D013223:Statistics as Topic; D014706:Verbal Learning / Q000502:physiology; D055815:Young Adult