title: Polymorphisms in genes encoding interleukin-10 and drug metabolizing enzymes GSTP1, GSTT1, GSTA1 and UGT1A1 influence risk and outcome in Hodgkin lymphoma.
abstract: We genotyped 224 patients with Hodgkin lymphoma (HL) and 1056 healthy controls and related the risk for HL and outcome of chemotherapy treatment to polymorphisms in genes encoding interleukins and metabolizing enzymes by capillary electrophoresis. Patients with the UGT1A1 TA tandem repeat TA6/6 genotype had a poorer overall survival (OS) (relative risk [RR] 3.63, p = 0.004), and patients above 40 years with the GSTA1 AA genotype had poorer event-free survival (EFS) (RR 4.38, p = 0.003) after chemotherapy. In patients above 40 years, the IL-10 rs1800890 T-allele was associated with lower risk for HL (TT genotype vs. AA, odds ratio [OR] 0.38 [95% confidence interval 0.21-0.69], p = 0.001; AT/TT combined genotypes vs. AA, OR 0.45 [0.27-0.74], p = 0.001). The GSTP1 rs1695 A-allele reduced the risk for HL (GG vs. AG, OR 0.64 [0.42-0.99], p = 0.04; GG vs. AG/AA combined genotypes, OR 0.70 [0.47-1.04], p = 0.07), and the GSTT1 deleted genotype increased the risk for HL (OR 3.17 [1.97-5.09], p < 0.001) regardless of age.
authors.affiliation: Division for Surgery and Cancer Medicine, Institute for Cancer Research, The Norwegian Radium Hospital and Oslo University Hospital, Oslo, Norway. olav.yri@rr-research.no
authors.forename: Olav E
authors.initials: OE
authors.lastname: Yri
authors.forename: Per O
authors.initials: PO
authors.lastname: Ekstrøm
authors.forename: Vera
authors.initials: V
authors.lastname: Hilden
authors.forename: Gustav
authors.initials: G
authors.lastname: Gaudernack
authors.forename: Knut
authors.initials: K
authors.lastname: Liestøl
authors.forename: Erlend B
authors.initials: EB
authors.lastname: Smeland
authors.forename: Harald
authors.initials: H
authors.lastname: Holte
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D014453:Glucuronosyltransferase / Q000235:genetics*; D051549:Glutathione S-Transferase pi / Q000235:genetics*; D005982:Glutathione Transferase / Q000235:genetics*; D006689:Hodgkin Disease / Q000235:genetics* / Q000401:mortality; D006801:Humans; D008658:Inactivation, Metabolic / Q000235:genetics; D016753:Interleukin-10 / Q000235:genetics*; D007527:Isoenzymes / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D012306:Risk; D055815:Young Adult
chemical_list: D007527:Isoenzymes; D016753:Interleukin-10; D014453:Glucuronosyltransferase; C413545:glutathione S-transferase T1; D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase; C119995:glutathione S-transferase alpha