title: High-sensitivity C reactive protein: associations with cardiovascular risk factors and tracking in female adolescents and young adults.
abstract: Objective. We assessed adolescent anthropometry, lipids, insulin, glucose, and blood pressures to identify factors associated with high-sensitivity C-reactive protein (hsCRP) and its tracking in young adults. Methods. Ten-year prospective study of 589 schoolgirls, 321 black, 268 white. Results. HsCRP did not differ (P > .08) by race or oral contraceptive use. HsCRP tracked from age 16 to 25 (r = 0.77), 16 to 26 (r = 0.50), 24 to 26 (r = 0.66), and 25 to 26 (r = 0.71), all P ≤ .02. By stepwise regression, at age 16, waist circumference accounted for 44.8% of hsCRP variance; BMI accounted for 33.1%, 34.4%, and 31.1% at ages 24, 25, and 26, P < .0001 for all. Changes in cholesterol and BMI were associated with change in hsCRP from age 24-26 (partial R(2) = 12.3%  P < .0001, 6.6%  P = .0012). Changes in BMI and triglyceride (partial R(2) = 8.5%  P = .0001, 3.3%, P = .0045) were associated with change in hsCRP from age 25 to 26. Conclusions. HsCRP tracks from age 16 to 26, with BMI, waist circumference, and cholesterol as major determinants.
authors.affiliation: Division of Cardiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229-3039, USA.
authors.forename: John A
authors.initials: JA
authors.lastname: Morrison
authors.forename: Charles J
authors.initials: CJ
authors.lastname: Glueck
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Daniels
authors.forename: Ping
authors.initials: P
authors.lastname: Wang
authors.forename: Davis M
authors.initials: DM
authors.lastname: Stroop
authors.forename: Paul S
authors.initials: PS
authors.lastname: Horn