title: Synthesis of heparan sulfate tetrasaccharide as a substrate for human heparanase.
abstract: Regiospecifically sulfated heparan sulfate tetrasaccharide, GlcAβ-GlcN(NS6S)α-GlcAβ-GlcN(NS6S)α was first synthesized as an octyl glycoside. Total synthesis was achieved effectively by coupling the corresponding disaccharide units in short steps.
authors.affiliation: Department of Regional Environment, Tottori University, Tottori 680-8551, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Takeda
authors.forename: Remina
authors.initials: R
authors.lastname: Ikeda-Matsumi
authors.forename: Kaoru
authors.initials: K
authors.lastname: Ebara-Nagahara
authors.forename: Miyuki
authors.initials: M
authors.lastname: Otaki-Nanjo
authors.forename: Kayo
authors.initials: K
authors.lastname: Taniguchi-Morita
authors.forename: Miwa
authors.initials: M
authors.lastname: Nanjo
authors.forename: Jun-ichi
authors.initials: J
authors.lastname: Tamura
mesh_terms: D002240:Carbohydrate Sequence; D005966:Glucuronidase / Q000378:metabolism*; D006497:Heparan Sulfate / Q000737:chemistry*; D006801:Humans; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism*; D013379:Substrate Specificity; D000099175:Heparanase
chemical_list: D005966:Glucuronidase; D006497:Heparan Sulfate; D009844:Oligosaccharides; D000099175:Heparanase