title: CD73: a potent suppressor of antitumor immune responses.
abstract: Tumors use several strategies to evade immunosurveillance. One such mechanism is the generation of adenosine within the tumor microenvironment, which potently suppresses antitumor T cell responses. Adenosine within the tumor is generated by CD73, a membrane-bound nucleotidase that is expressed by tumor cells, suppressive immune subsets such as T regulatory cells (Tregs) and myeloid-derived suppressor cells and endothelial cells. Recent evidence suggests that targeted inhibition of CD73 has the potential to reduce tumorigenesis and metastasis, as well as enhancing the potency of T-cell-directed therapies. This review outlines the impact of adenosine on suppressing the antitumor response and the evidence supporting the rationale for CD73 targeting in the treatment of cancer.
authors.affiliation: Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, St. Andrews Place, East Melbourne, Victoria 3002, Australia. paul.beavis@petermac.org
authors.forename: Paul A
authors.initials: PA
authors.lastname: Beavis
authors.forename: John
authors.initials: J
authors.lastname: Stagg
authors.forename: Phillip K
authors.initials: PK
authors.lastname: Darcy
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Smyth
mesh_terms: D015720:5'-Nucleotidase / Q000276:immunology*; D000241:Adenosine / Q000276:immunology; D000818:Animals; D018450:Disease Progression; D006801:Humans; D007108:Immune Tolerance; D009369:Neoplasms / Q000175:diagnosis / Q000276:immunology*
chemical_list: D015720:5'-Nucleotidase; D000241:Adenosine