title: Platelet-rich plasma improves wound healing in multiple myeloma bisphosphonate-associated osteonecrosis of the jaw patients.
abstract: Bisphosphonates are drugs used to treat various metabolic and malignant bone diseases. In the past 10 years intravenous bisphosphonates have been associated with increased risk of osteonecrosis of the jaw (ONJ). The aim of the present study is to evaluate platelet-rich plasma (PRP) wound healing benefits in multiple myeloma (MM) patients who developed ONJ after surgical tooth extraction. The study included 7 patients, 2 males and 5 females. All individuals had been taking zoledronate or pamidronate followed by zoledronate for an average of 5 years. Four subjects had only standard surgical debridement and sequestrectomy to treat the ONJ and three had additional autologous PRP. The patients were followed-up for 3 months. The use of PRP to enhance wound healing and reduce bone exposure seems to be a good treatment protocol in ONJ MM subjects.
authors.forename: V
authors.initials: V
authors.lastname: Coviello
authors.forename: F
authors.initials: F
authors.lastname: Peluso
authors.forename: S Z
authors.initials: SZ
authors.lastname: Dehkhargani
authors.forename: F
authors.initials: F
authors.lastname: Verdugo
authors.forename: L
authors.initials: L
authors.lastname: Raffaelli
authors.forename: P F
authors.initials: PF
authors.lastname: Manicone
authors.forename: A
authors.initials: A
authors.lastname: D' Addona
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000628:therapy*; D001804:Blood Transfusion, Autologous; D004164:Diphosphonates / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D007093:Imidazoles / Q000009:adverse effects / Q000627:therapeutic use; D009101:Multiple Myeloma / Q000150:complications*; D000077268:Pamidronate; D053657:Platelet-Rich Plasma; D014081:Tooth Extraction / Q000009:adverse effects*; D014945:Wound Healing; D000077211:Zoledronic Acid
chemical_list: D004164:Diphosphonates; D007093:Imidazoles; D000077211:Zoledronic Acid; D000077268:Pamidronate