title: Targeting β-catenin in CML: leukemia stem cells beware!
abstract: In this issue of Cell Stem Cell, Heidel et al. (2012) use genetic and pharmacological approaches to reveal that Wnt/β-catenin signaling is required for leukemic stem cell (LSC) maintenance in chronic myeloid leukemia. They demonstrate that β-catenin inactivation targets imanitib-resistant LSCs in vivo.
authors.affiliation: Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
authors.forename: Maria
authors.initials: M
authors.lastname: Kleppe
authors.forename: Ross L
authors.initials: RL
authors.lastname: Levine