title: Association of ADIPOQ variants, total and high molecular weight adiponectin levels with coronary artery disease in diabetic and non-diabetic Brazilian subjects.
abstract: OBJECTIVE
  To investigate the association of ADIPOQ variants, total and high molecular weight adiponectin (HMW) adiponectin levels with the prevalence of diabetes mellitus and coronary artery disease (CAD) diagnosed by coronary angiography in Brazilian subjects with high cardiovascular risk.
  
  
  METHODS
  603 subjects undergoing coronary angiography were studied in regard to their glycemic status and presence of CAD (lesions >0%). We evaluated baseline concentrations of total and HMW adiponectin and three ADIPOQ variants: -11391G>A (rs17300539), +45T>G (rs2241766) and+276G>T (rs1501299).
  
  
  RESULTS
  The G-allele of rs2241766 was associated with higher levels of total and HMW adiponectin, and the A-allele of rs17300539 was associated with higher levels of HMW adiponectin. Lower levels of total and HMW adiponectin were independently associated with CAD. The G-allele of rs2241766 (OR 2.45, 95% C.I. 1.05-6.04, p=0.04) and the G-allele of rs1501299 (OR 1.89, 95% C.I. 1.04-3.45, p=0.03) were associated with CAD, and these associations were independent of circulating levels of adiponectin.
  
  
  CONCLUSIONS
  In Brazilian subjects with high cardiovascular risk, CAD was associated with lower total and HMW adiponectin levels. The rs2241766 and rs1501299 polymorphisms were associated with CAD. The rs2241766 variant was associated with total and HMW adiponectin levels, while rs17300539 was associated with HMW adiponectin levels.
authors.affiliation: Federal University of São Paulo (UNIFESP), Endocrinology Unit, São Paulo, Brazil.
authors.forename: Carolina S V
authors.initials: CS
authors.lastname: Oliveira
authors.forename: Pedro
authors.initials: P
authors.lastname: Saddi-Rosa
authors.forename: Felipe
authors.initials: F
authors.lastname: Crispim
authors.forename: Luis H
authors.initials: LH
authors.lastname: Canani
authors.forename: Fernando
authors.initials: F
authors.lastname: Gerchman
authors.forename: Fernando M A
authors.initials: FM
authors.lastname: Giuffrida
authors.forename: José G H
authors.initials: JG
authors.lastname: Vieira
authors.forename: Gilberto
authors.initials: G
authors.lastname: Velho
authors.forename: André F
authors.initials: AF
authors.lastname: Reis
mesh_terms: D052242:Adiponectin / Q000097:blood / Q000235:genetics*; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D001938:Brazil / Q000453:epidemiology; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D058065:Diabetic Cardiomyopathies / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D015995:Prevalence
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007328:Insulin; D008055:Lipids; C499918:ADIPOQ protein, human; C517652:hemoglobin A1c protein, human