title: Recent developments in the management of T-cell precursor acute lymphoblastic leukemia/lymphoma.
abstract: T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma are uncommon disorders classified together by the World Health Organization classification as "T-lymphoblastic leukemia/lymphoma." This review gives an overview on the treatment of these aggressive but curable T cell malignancies in adult patients, in order to highlight current developments. The most interesting and relevant developments are in our understanding of the genetics of T-ALL/LBL and how the genetics relate to clinical outcome. These studies will inform clinicians as to which targeted novel agents may be of value and how patients may be best risk-stratified to receive them.
authors.affiliation: Department of Hematology, University College London, Royal Free Campus, London, UK. a.fielding@ucl.ac.uk
authors.forename: Adele K
authors.initials: AK
authors.lastname: Fielding
authors.forename: Lalita
authors.initials: L
authors.lastname: Banerjee
authors.forename: David I
authors.initials: DI
authors.lastname: Marks
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D019468:Disease Management; D004791:Enzyme Inhibitors / Q000627:therapeutic use; D006801:Humans; D010641:Phenotype; D054218:Precursor T-Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics / Q000276:immunology / Q000628:therapy*; D011379:Prognosis; D033581:Stem Cell Transplantation / Q000379:methods; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors