title: Corticosteroids provoke acute endothelial injury -- an ideal ground for thrombosis in multiple sclerosis.
abstract: Despite the effect corticosteroids exert on blood clotting and the irrefutable impact of intracranial sure decreasing shortly after lumbar puncture, a certain number of intracranial thromboses remain unexplained. Corticosteroids are useful in reducing the severity and duration of relapses of multiple sclerosis. Several questions emerge concerning the reasons behind thrombosis occurring so sporadically, not pertaining to any rule, the most important of which regard the location and timing. We developed this hypothesis as an obverse to chronic endothelial injury theory which, only partially explains atherosclerosis development. We followed Virchows classical triad of conditions which are believed to be connected to the development of thrombosis. Although corticosteroids affect more than vessel wall injury, component of Virchows triad that has been our narrowest interest is exactly vessel wall injury.
authors.forename: I
authors.initials: I
authors.lastname: Sosa
authors.forename: I
authors.initials: I
authors.lastname: Strenja Linic
authors.forename: S
authors.initials: S
authors.lastname: Stifter
authors.forename: S
authors.initials: S
authors.lastname: Bajek
authors.forename: D
authors.initials: D
authors.lastname: Cuculic
authors.forename: Z
authors.initials: Z
authors.lastname: Crncevic-Orlic
authors.forename: A
authors.initials: A
authors.lastname: Grubesic
authors.forename: O
authors.initials: O
authors.lastname: Cvijanovic
authors.forename: A
authors.initials: A
authors.lastname: Bosnar
mesh_terms: D000305:Adrenal Cortex Hormones / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use*; D050197:Atherosclerosis / Q000209:etiology; D001808:Blood Vessels / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004730:Endothelium, Vascular / Q000187:drug effects*; D005260:Female; D006801:Humans; D020767:Intracranial Thrombosis / Q000139:chemically induced / Q000209:etiology*; D008297:Male; D009103:Multiple Sclerosis / Q000150:complications / Q000188:drug therapy*
chemical_list: D000305:Adrenal Cortex Hormones