title: Relationship of ECG findings to phenotypic expression in patients with hypertrophic cardiomyopathy: a cardiac magnetic resonance study.
abstract: BACKGROUND
  The 12-lead electrocardiogram (ECG) is considered an essential screening tool for hypertrophic cardiomyopathy (HCM). A vast array of ECG abnormalities has been described in HCM, although their relationship to left ventricle (LV) morphology and degree of hypertrophy appears elusive. Aim of this study was to assess the relationship of ECG patterns with the HCM phenotype assessed according to the novel opportunities offered by cardiac magnetic imaging (CMR).
  
  
  METHODS
  CMR and 12-lead ECG were performed in 257 HCM patients. Severity of ECG abnormalities was defined by the sum of 9 criteria: abnormal cardiac rhythm, QRS duration ≥ 100 ms, Romhilt-Estes score ≥ 5, fascicular block (LAHB) and/or bundle-branch block (LBBB or RBBB), ST-T abnormalities, ST-T segment elevation ≥ 0.2 mV, prolonged QTc interval, pathological Q waves, absence of normal Q wave. Four ECG groups were identified: normal (0 criteria); mildly abnormal (1-3 criteria); moderately abnormal (4-6 criteria); markedly abnormal (7-9 criteria).
  
  
  RESULTS
  There was a direct relationship between severity of ECG abnormalities and HCM phenotype. LV mass index was normal in most patients with normal ECG and progressively increased with each class of ECG score, from 70.9 ± 18.6g/m(2) in patients with normal ECG to 107.1 ± 55.1g/m(2) among those with markedly abnormal ECG (p=<0.0001). Likewise, the prevalence and extent of late gadolinium enhancement (LGE) increased significantly with the ECG score, from 37% in patients with normal ECG to 93% in patients with markedly abnormal ECG (overall p=0.0012). A normal ECG had a negative predictive accuracy of 96% for markedly increased LV mass (>91 g/m(2) for men and >69 g/m(2) for women), and of 100% for maximum LV thickness ≥ 30 mm.
  
  
  CONCLUSIONS
  In a large HCM cohort, the number and severity of ECG abnormalities were directly related to phenotypic expression as revealed by CMR. Although false negative ECG findings remain a challenge in population screenings for HCM, a normal ECG proved effective in ruling out severe LV hypertrophy, suggesting potential implications for long-term follow-up of HCM patients and family members. A simple score for quantification of ECG abnormalities in HCM patients is proposed.
authors.affiliation: Division of Cardiology, Cardinal Massaia Hospital of Asti and Faculty of Medicine University of Turin, Asti, Italy. SDelcre@asl.at.it
authors.forename: Sara Dalila Luisella
authors.initials: SD
authors.lastname: Delcrè
authors.forename: Paolo
authors.initials: P
authors.lastname: Di Donna
authors.forename: Stefano
authors.initials: S
authors.lastname: Leuzzi
authors.forename: Salvatore
authors.initials: S
authors.lastname: Miceli
authors.forename: Marta
authors.initials: M
authors.lastname: Bisi
authors.forename: Marco
authors.initials: M
authors.lastname: Scaglione
authors.forename: Domenico
authors.initials: D
authors.lastname: Caponi
authors.forename: Maria Rosa
authors.initials: MR
authors.lastname: Conte
authors.forename: Franco
authors.initials: F
authors.lastname: Cecchi
authors.forename: Iacopo
authors.initials: I
authors.lastname: Olivotto
authors.forename: Fiorenzo
authors.initials: F
authors.lastname: Gaita
mesh_terms: D000328:Adult; D000368:Aged; D002312:Cardiomyopathy, Hypertrophic / Q000175:diagnosis* / Q000503:physiopathology*; D015331:Cohort Studies; D004562:Electrocardiography / Q000379:methods*; D005260:Female; D006801:Humans; D019028:Magnetic Resonance Imaging, Cine / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010641:Phenotype