title: Effects of amikacin on maturation of the auditory analyzer in rabbits.
abstract: We studied the dynamics of maturation of the hearing function by records of short-term latent brainstem evoked potentials and the effect of amikacin on maturation of the hearing function. The peripheral compartment of the auditory analyzer matures sooner than the central structures. Amikacin in therapeutic doses exhibited an ototoxic effect on the peripheral compartment of the auditory analyzer without impairing its central structures.
authors.affiliation: Research Laboratory of Clinical and Experimental Pediatric Otorhinolaryngology, Russian State Medical University, Ministry of Health Care and Social Development of the Russian Federation, Moscow, Russia.
authors.forename: I N
authors.initials: IN
authors.lastname: D'yakonova
authors.forename: I V
authors.initials: IV
authors.lastname: Rakhmanova
authors.forename: A M
authors.initials: AM
authors.lastname: Tikhomirov
authors.forename: Yu S
authors.initials: YS
authors.lastname: Ishanova
authors.forename: R V
authors.initials: RV
authors.lastname: Kotov
mesh_terms: D000583:Amikacin / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000633:toxicity; D001303:Auditory Cortex / Q000187:drug effects / Q000254:growth & development*; D001304:Auditory Diseases, Central / Q000139:chemically induced; D001307:Auditory Perception / Q000187:drug effects; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects; D005260:Female; D008297:Male; D011817:Rabbits
chemical_list: D000900:Anti-Bacterial Agents; D000583:Amikacin