title: Quinolinyl- and phenantridinyl-acetamides as bradykinin B1 receptor antagonists.
abstract: A new series of quinolinyl- and phenantridinyl-acetamides were synthesizer and evaluated against bradykinin B1 receptor. In vitro metabolic stability data were reported for the key compounds.The analgesic effect of compound 20 from the phenantridine series was proved in-vivo.
authors.affiliation: Gedeon Richter Plc., Budapest 10. POB 27, H-1475, Hungary. j.eles@richter.hu
authors.forename: János
authors.initials: J
authors.lastname: Eles
authors.forename: Gyula
authors.initials: G
authors.lastname: Beke
authors.forename: István
authors.initials: I
authors.lastname: Vágó
authors.forename: Eva
authors.initials: E
authors.lastname: Bozó
authors.forename: József
authors.initials: J
authors.lastname: Huszár
authors.forename: Akos
authors.initials: A
authors.lastname: Tarcsay
authors.forename: Sándor
authors.initials: S
authors.lastname: Kolok
authors.forename: Eva
authors.initials: E
authors.lastname: Schmidt
authors.forename: Mónika
authors.initials: M
authors.lastname: Vastag
authors.forename: Katalin
authors.initials: K
authors.lastname: Hornok
authors.forename: Sándor
authors.initials: S
authors.lastname: Farkas
authors.forename: György
authors.initials: G
authors.lastname: Domány
authors.forename: György M
authors.initials: GM
authors.lastname: Keserű
mesh_terms: D000081:Acetamides / Q000138:chemical synthesis* / Q000494:pharmacology; D000700:Analgesics / Q000138:chemical synthesis / Q000494:pharmacology; D065169:Bradykinin B1 Receptor Antagonists; D002460:Cell Line; D006801:Humans; D008660:Metabolism; D010616:Phenanthrenes / Q000138:chemical synthesis* / Q000494:pharmacology; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000081:Acetamides; D000700:Analgesics; D065169:Bradykinin B1 Receptor Antagonists; D010616:Phenanthrenes; D011804:Quinolines