title: Prevalence of transcranial Doppler abnormalities in Nigerian children with sickle cell disease.
abstract: Transcranial Doppler (TCD) ultrasonography helps to identify children with sickle cell disease (SCD) who are at an increased risk of stroke,making primary stroke prevention a reality. A cross-sectional study of145 Nigerian children aged ≥3 years with SCD was carried out to describe the pattern of cerebral blood flow (CBF) abnormalities. The mean time-averaged mean velocity (TAMV) was 152 ±27.0 cm/sec and122 ±22.0 cm/sec in Hb SS and Hb S1C group, respectively. Abnormal velocities were recorded in six (4.7%) of the Hb SS patients and none of the Hb S1C while conditional risk (CR) velocities were recorded in 19.7% of Hb SS (low conditional 11.0%, high conditional 8.7%) and low conditional in 5.6% of Hb S1C cases. Cerebral flow velocities showed a negative correlation with age and hematocrit. Compared with African-American children, Nigerian children with Hb SS disease have a considerably higher prevalence of CR velocities.
authors.affiliation: Department of Paediatrics, College of Medicine, University of Ibadan, Ibadan, Nigeria. ilagunju@yahoo.co.uk
authors.forename: IkeOluwa
authors.initials: I
authors.lastname: Lagunju
authors.forename: Olugbemiro
authors.initials: O
authors.lastname: Sodeinde
authors.forename: Paul
authors.initials: P
authors.lastname: Telfer
mesh_terms: D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000097:blood / Q000000981:diagnostic imaging / Q000235:genetics / Q000503:physiopathology*; D001772:Blood Cell Count; D001783:Blood Flow Velocity; D001921:Brain / Q000098:blood supply*; D002536:Cerebral Arteries / Q000000981:diagnostic imaging* / Q000473:pathology; D002560:Cerebrovascular Circulation; D002648:Child; D002675:Child, Preschool; D003251:Constriction, Pathologic; D005260:Female; D006400:Hematocrit; D006445:Hemoglobin C Disease / Q000097:blood / Q000000981:diagnostic imaging / Q000235:genetics / Q000503:physiopathology; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008297:Male; D009549:Nigeria / Q000453:epidemiology; D015995:Prevalence; D012306:Risk; D012805:Sickle Cell Trait / Q000097:blood / Q000000981:diagnostic imaging / Q000235:genetics / Q000503:physiopathology; D020521:Stroke / Q000209:etiology / Q000517:prevention & control*; D017585:Ultrasonography, Doppler, Transcranial