title: Physiological regulation of cardiac contractility by endogenous reactive oxygen species.
abstract: Increased production of reactive oxygen species (ROS) has been linked to the pathogenesis of congestive heart failure. However, emerging evidence suggests the involvement of ROS in the regulation of various physiological cellular processes in the myocardium. In this review, we summarize the latest findings regarding the role of ROS in the acute regulation of cardiac contractility. We discuss ROS-dependent modulation of the inotropic responses to G protein-coupled receptor agonists (e.g. β-adrenergic receptor agonists and endothelin-1), the potential cellular sources of ROS (e.g. NAD(P)H oxidases and mitochondria) and the proposed end-targets and signalling pathways by which ROS affect contractility. Accumulating new data supports the fundamental role of endogenously generated ROS to regulate cardiac function under physiological conditions.
authors.affiliation: Heart Institute, Medical School, University of Pécs, Hungary.
authors.forename: A
authors.initials: A
authors.lastname: Perjés
authors.forename: A M
authors.initials: AM
authors.lastname: Kubin
authors.forename: A
authors.initials: A
authors.lastname: Kónyi
authors.forename: S
authors.initials: S
authors.lastname: Szabados
authors.forename: A
authors.initials: A
authors.lastname: Cziráki
authors.forename: R
authors.initials: R
authors.lastname: Skoumal
authors.forename: H
authors.initials: H
authors.lastname: Ruskoaho
authors.forename: I
authors.initials: I
authors.lastname: Szokodi
mesh_terms: D000818:Animals; D019332:Endothelin-1 / Q000378:metabolism; D006321:Heart / Q000502:physiology*; D006801:Humans; D009200:Myocardial Contraction / Q000502:physiology*; D009206:Myocardium / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism*; D011943:Receptors, Adrenergic, beta / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
chemical_list: D019332:Endothelin-1; D017382:Reactive Oxygen Species; D011943:Receptors, Adrenergic, beta