title: Mesenchymal stromal cell-based treatment of jaw osteoradionecrosis in Swine.
abstract: Jaw osteoradionecrosis (ORN) is a common and serious complication of radiation therapy for head and neck cancers. Bone marrow mesenchymal stromal cells (BMMSCs) are multipotent postnatal stem cells and have been widely used in clinical therapies. In the present study, we generated the  mandibular ORN model in swine using a combination of single-dose 25-Gy irradiation and tooth extraction. A typical ORN phenotype, including loss of bone regeneration capacity and collagen collapse with the obliteration of vessels, gradually appeared after irradiation. After autologous BMMSC  transplantation, new bone and vessels were regenerated, and the advanced mandibular ORN was treated successfully. In summary, we developed a swine model of jaw ORN, and our results indicate that autologous BMMSC transplantation may be a promising therapeutic approach for ORN.
authors.affiliation: Molecular Laboratory for Gene Therapy and Tooth Regeneration, Capital Medical University School of Stomatology, Beijing, China.
authors.forename: Junji
authors.initials: J
authors.lastname: Xu
authors.forename: Zongmei
authors.initials: Z
authors.lastname: Zheng
authors.forename: Dianji
authors.initials: D
authors.lastname: Fang
authors.forename: Runtao
authors.initials: R
authors.lastname: Gao
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
authors.forename: Zhipeng
authors.initials: Z
authors.lastname: Fan
authors.forename: Chunmei
authors.initials: C
authors.lastname: Zhang
authors.forename: Songtao
authors.initials: S
authors.lastname: Shi
authors.forename: Songlin
authors.initials: S
authors.lastname: Wang
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000166:cytology; D001861:Bone Regeneration / Q000502:physiology; D016371:Cranial Irradiation / Q000009:adverse effects; D004195:Disease Models, Animal; D008336:Mandibular Diseases / Q000000981:diagnostic imaging / Q000209:etiology / Q000628:therapy*; D045164:Mesenchymal Stem Cell Transplantation; D059630:Mesenchymal Stem Cells / Q000166:cytology*; D010025:Osteoradionecrosis / Q000000981:diagnostic imaging / Q000209:etiology / Q000628:therapy*; D013552:Swine; D014057:Tomography, X-Ray Computed; D014081:Tooth Extraction / Q000009:adverse effects