title: Immunogenicity of two adjuvant formulations of an inactivated African horse sickness vaccine in guinea-pigs and target animals.
abstract: Monovalent, inactivated and adjuvanted vaccines against African horse sickness, prepared with serotypes 5 and 9, were tested on guinea-pigs to select the formulation that offered the greatest immunity. The final formulation of the vaccines took into account the immune response in the guinea-pig and the inflammatory properties of two types of adjuvant previously tested on target animals. A pilot study was subsequently conducted on horses using a vaccine prepared with serotype 9. The vaccine stimulated neutralising antibodies from the first administration and, after the booster dose, 28 days later; high antibody levels were recorded for at least 10 months. The guinea-pig appears to be a useful laboratory model for the evaluation of the antigenic properties of African horse sickness vaccines.
authors.affiliation: Istituto Zooprofilattico Sperimentale dell'Abruzzo e del Molise 'G. Caporale', Campo Boario, 64100 Teramo, Italy. f.ronchi@izs.it
authors.forename: Gaetano Federico
authors.initials: GF
authors.lastname: Ronchi
authors.forename: Simonetta
authors.initials: S
authors.lastname: Ulisse
authors.forename: Emanuela
authors.initials: E
authors.lastname: Rossi
authors.forename: Paola
authors.initials: P
authors.lastname: Franchi
authors.forename: Gisella
authors.initials: G
authors.lastname: Armillotta
authors.forename: Sara
authors.initials: S
authors.lastname: Capista
authors.forename: Agostino
authors.initials: A
authors.lastname: Peccio
authors.forename: Mauro
authors.initials: M
authors.lastname: Di Ventura
authors.forename: Attilio
authors.initials: A
authors.lastname: Pini
mesh_terms: D000276:Adjuvants, Immunologic; D000355:African Horse Sickness / Q000517:prevention & control*; D000356:African Horse Sickness Virus / Q000145:classification / Q000276:immunology*; D000818:Animals; D005260:Female; D006168:Guinea Pigs; D006734:Horse Diseases / Q000517:prevention & control; D006736:Horses; D012703:Serotyping; D015164:Vaccines, Inactivated / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D000276:Adjuvants, Immunologic; D015164:Vaccines, Inactivated; D014765:Viral Vaccines