title: Angiopoietin-like protein 4: health effects, modulating agents and structure-function relationships.
abstract: Angiopoietin-like protein 4 (ANGPTL4) has been identified as a multifunctional signal protein. It is produced by a variety of tissues, and is secreted into the bloodstream in glycosylated, oligomerized, native and cleaved isoforms to modulate physiological events such as angiogenesis, cell differentiation and the crosstalk between liver, brain, adipose and muscle tissue in lipid and glucose metabolism. In addition, the expression and isoform appearance of ANGPTL4 are modified by the intestinal microbiota. With an eye on an effective strategy to improve health using ANGPTL4, we will focus on: health issues associated with ANGPTL4 expression, including obesity, Type 2 diabetes, cardiovascular diseases and cancer; several modulators of ANGPTL4 of chemical, microbiological, food and host origin; and the correlation of the specific ANGPTL4 isoforms with these modulators and their health effects.
authors.affiliation: Laboratory of Microbial Ecology & Technology (LabMET), Ghent University, Ghent, Belgium. charlotte.grootaert@ugent.be
authors.forename: Charlotte
authors.initials: C
authors.lastname: Grootaert
authors.forename: Tom
authors.initials: T
authors.lastname: Van de Wiele
authors.forename: Willy
authors.initials: W
authors.lastname: Verstraete
authors.forename: Marc
authors.initials: M
authors.lastname: Bracke
authors.forename: Barbara
authors.initials: B
authors.lastname: Vanhoecke
mesh_terms: D000075803:Angiopoietin-Like Protein 4; D042682:Angiopoietins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D002318:Cardiovascular Diseases / Q000378:metabolism; D004734:Energy Metabolism; D041981:Gastrointestinal Tract / Q000378:metabolism / Q000382:microbiology; D006801:Humans; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism; D008659:Metabolic Diseases; D009369:Neoplasms / Q000378:metabolism; D009928:Organ Specificity; D047492:Peroxisome Proliferator-Activated Receptors / Q000819:agonists / Q000378:metabolism; D020033:Protein Isoforms / Q000378:metabolism / Q000502:physiology
chemical_list: C474772:ANGPTL4 protein, human; D000075803:Angiopoietin-Like Protein 4; D042682:Angiopoietins; D047492:Peroxisome Proliferator-Activated Receptors; D020033:Protein Isoforms