title: Transcatheter aortic valve replacement: outcomes of patients with moderate or severe mitral regurgitation.
abstract: OBJECTIVE
  The aim of this study was to evaluate the impact of mitral regurgitation (MR) on outcomes after transcatheter aortic valve replacement (TAVR) and the impact of TAVR on MR.
  
  
  BACKGROUND
  Little is known of the influence of MR on outcomes after TAVR.
  
  
  METHODS
  The outcomes of patients with mild or less (n = 319), moderate (n = 89), and severe (n = 43) MR were evaluated after TAVR at 2 Canadian centers.
  
  
  RESULTS
  Patients with moderate or severe MR had a higher mortality rate than those with mild or less MR during the 30 days after TAVR (adjusted hazard ratio: 2.10; 95% confidence interval: 1.12 to 3.94; p = 0.02). However, the mortality rates after 30 days were similar (adjusted hazard ratio: 0.82; 95% confidence interval: 0.50 to 1.34; p = 0.42). One year after TAVR, moderate MR had improved in 58%, remained moderate in 17%, and worsened to severe in 1%, and 24% of patients had died. Severe MR had improved in 49% and remained severe in 16%, and 35% of patients had died. Multivariate predictors of improved MR at 1 year (vs. unchanged MR, worse MR, or death) were a mean transaortic gradient ≥ 40 mm Hg, functional (as opposed to structural) MR, the absence of pulmonary hypertension, and the absence of atrial fibrillation.
  
  
  CONCLUSIONS
  Moderate or severe MR in patients undergoing TAVR is associated with a higher early, but not late, mortality rate. At 1-year follow-up, MR was improved in 55% of patients with moderate or severe MR at baseline. Improvement was more likely in patients with high transaortic gradients, with functional MR, without pulmonary hypertension and without atrial fibrillation.
authors.affiliation: St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada.
authors.forename: Stefan
authors.initials: S
authors.lastname: Toggweiler
authors.forename: Robert H
authors.initials: RH
authors.lastname: Boone
authors.forename: Josep
authors.initials: J
authors.lastname: Rodés-Cabau
authors.forename: Karin H
authors.initials: KH
authors.lastname: Humphries
authors.forename: May
authors.initials: M
authors.lastname: Lee
authors.forename: Luis
authors.initials: L
authors.lastname: Nombela-Franco
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Bagur
authors.forename: Alexander B
authors.initials: AB
authors.lastname: Willson
authors.forename: Ronald K
authors.initials: RK
authors.lastname: Binder
authors.forename: Ronen
authors.initials: R
authors.lastname: Gurvitch
authors.forename: Jasmine
authors.initials: J
authors.lastname: Grewal
authors.forename: Robert
authors.initials: R
authors.lastname: Moss
authors.forename: Brad
authors.initials: B
authors.lastname: Munt
authors.forename: Christopher R
authors.initials: CR
authors.lastname: Thompson
authors.forename: Melanie
authors.initials: M
authors.lastname: Freeman
authors.forename: Jian
authors.initials: J
authors.lastname: Ye
authors.forename: Anson
authors.initials: A
authors.lastname: Cheung
authors.forename: Eric
authors.initials: E
authors.lastname: Dumont
authors.forename: David A
authors.initials: DA
authors.lastname: Wood
authors.forename: John G
authors.initials: JG
authors.lastname: Webb
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001024:Aortic Valve Stenosis / Q000150:complications / Q000000981:diagnostic imaging / Q000401:mortality* / Q000628:therapy*; D001705:Bioprosthesis; D001955:British Columbia; D006328:Cardiac Catheterization / Q000379:methods; D015331:Cohort Studies; D015150:Echocardiography, Doppler; D005260:Female; D005500:Follow-Up Studies; D006350:Heart Valve Prosthesis; D019918:Heart Valve Prosthesis Implantation / Q000379:methods* / Q000401:mortality*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D019060:Minimally Invasive Surgical Procedures / Q000379:methods / Q000401:mortality; D008944:Mitral Valve Insufficiency / Q000150:complications / Q000000981:diagnostic imaging / Q000401:mortality* / Q000628:therapy*; D016017:Odds Ratio; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D011475:Prosthesis Failure; D012189:Retrospective Studies; D018570:Risk Assessment; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D016019:Survival Analysis; D013997:Time Factors; D016896:Treatment Outcome