title: Cytotoxic cytochalasins from the endozoic fungus Phoma sp. of the giant jellyfish Nemopilema nomurai.
abstract: Four new cytochalasin derivatives (1-4), together with cytochalasin B (5), were isolated from the fungus Phoma sp. obtained from the giant jellyfish Nemopilema nomurai. The planar structure and relative stereochemistry were established by analysis of 1D and 2D NMR data. The absolute configuration was defined by the modified Mosher's method. The compounds showed significant cytotoxicity against a small panel of human solid tumor cell lines (A549, SK-OV-3, SK-MEL-2, XF 498, and HCT15) with IC(50) values in the range of 0.5-30 μM. The cytochalasin B (5) showed obvious cytotoxicity with IC(50) of 7.9 μM against HeLa human cervical carcinoma cells.
authors.affiliation: College of Pharmacy, Pusan National University, Busan 609-735, Republic of Korea.
authors.forename: Eun La
authors.initials: EL
authors.lastname: Kim
authors.forename: Jian Lin
authors.initials: JL
authors.lastname: Li
authors.forename: Hung The
authors.initials: HT
authors.lastname: Dang
authors.forename: Jongki
authors.initials: J
authors.lastname: Hong
authors.forename: Chong-Ok
authors.initials: CO
authors.lastname: Lee
authors.forename: Dong-Kyoo
authors.initials: DK
authors.lastname: Kim
authors.forename: Won Duk
authors.initials: WD
authors.lastname: Yoon
authors.forename: Euikyung
authors.initials: E
authors.lastname: Kim
authors.forename: Yonghong
authors.initials: Y
authors.lastname: Liu
authors.forename: Jee H
authors.initials: JH
authors.lastname: Jung
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry; D001203:Ascomycota / Q000737:chemistry*; D016923:Cell Death / Q000187:drug effects; D045744:Cell Line, Tumor; D003572:Cytochalasins / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D055088:Early Detection of Cancer; D006801:Humans; D020128:Inhibitory Concentration 50; D015394:Molecular Structure; D037401:Scyphozoa / Q000382:microbiology*
chemical_list: D000970:Antineoplastic Agents; D003572:Cytochalasins