title: Investigation of parvovirus B19 seroprevalence, endothelin-1 synthesis, and nitric oxide levels in the etiology of essential hypertension.
abstract: OBJECTIVE
  Many studies have focused on the role of pathogen infection in hypertension (HT). It has been postulated that increased vascular tonus in HT is basically related to the imbalance between vasodilator, such as nitric oxide (NO), and vasoconstrictor, such as endothelin-1 (ET-1), substances secreted by endothelium. The aim of the present study was to investigate the seroprevalence of human parvovirus B19 (HPV B19) in the etiology of essential HT and the effect of HPV B19 on ET-1 and NO levels in this disorder.
  
  
  METHODS
  A total of 135 participants were enrolled in the study (90 patient and 45 controls). Antibodies to HPV B19 and ET-1 were measured by enzyme-linked immunosorbent assay method. Nitric oxide levels were calculated according to the Griess reaction.
  
  
  RESULTS
  Of the total participants, 27 patients (30%) and 7 control subjects (15.6%) had IgM positive (P = .068), whereas 27 patients (30%) and 14 control subjects (31.1%) had IgG positive (P = .895). There was no statistical difference between patients and control subjects in terms of serum ET-1 and NO levels.
  
  
  CONCLUSIONS
  The role of HPV B19 in the etiology of essential HT was not shown in the present study. A larger sample may be needed for the investigation of these relations.
authors.affiliation: Department of Infectious Disease and Clinical Microbiology, Mustafa Kemal University Medical School, Hatay, Turkey. vicdanmotor@mku.edu.tr
authors.forename: Vicdan Koksaldi
authors.initials: VK
authors.lastname: Motor
authors.forename: Secil
authors.initials: S
authors.lastname: Arica
authors.forename: Sedat
authors.initials: S
authors.lastname: Motor
authors.forename: Nigar
authors.initials: N
authors.lastname: Yilmaz
authors.forename: Omer
authors.initials: O
authors.lastname: Evirgen
authors.forename: Melek
authors.initials: M
authors.lastname: Inci
authors.forename: Cumali
authors.initials: C
authors.lastname: Gokce
authors.forename: Yusuf
authors.initials: Y
authors.lastname: Onlen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000914:Antibodies, Viral / Q000097:blood; D016022:Case-Control Studies; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000209:etiology* / Q000821:virology; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood*; D010322:Parvoviridae Infections / Q000150:complications* / Q000453:epidemiology; D016732:Parvovirus B19, Human / Q000276:immunology / Q000472:pathogenicity; D016036:Seroepidemiologic Studies; D014421:Turkey / Q000453:epidemiology
chemical_list: D000914:Antibodies, Viral; D019332:Endothelin-1; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D009569:Nitric Oxide