title: Myxoid liposarcoma: a case report of a sentinel metastasis to the parotid gland with molecular confirmation.
abstract: Myxoid liposarcoma is a subtype of liposarcoma with a predilection for the deep soft tissues of the extremities that accounts approximately for 10% of all adult soft tissue sarcomas. We report a case of a metastatic myxoid liposarcoma to the parotid gland, with fine-needle aspiration cytology correlation and molecular characterization. The lesion was diagnosed in a 53-year-old Hispanic male who presented with a left posterior thigh mass. A core needle biopsy established the diagnosis of myxoid liposarcoma. The patient underwent limb-sparing, wide local excision of the malignancy and later presented with an initial metastatic lesion to the parotid gland. The diagnosis of metastatic myxoid liposarcoma was rendered by fine-needle aspiration cytology with cell block preparation, and molecular confirmation. Although myxoid/round cell liposarcomas are classically described as having minimal pleomorphism on cytologic material, we encountered significant pleomorphism in our case. Therefore, a diagnosis of myxoid/round cell liposarcoma should still be a diagnostic consideration even if markedly pleomorphic cells are seen in fine-needle aspiration biopsies.
authors.affiliation: Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA.
authors.forename: Laura
authors.initials: L
authors.lastname: Been
authors.forename: Adriana
authors.initials: A
authors.lastname: Olar
authors.forename: Martin P
authors.initials: MP
authors.lastname: Powers
authors.forename: Dolores
authors.initials: D
authors.lastname: López-Terrada
authors.forename: Rodolfo
authors.initials: R
authors.lastname: Lauririca
mesh_terms: D001483:Base Sequence; D044963:Biopsy, Fine-Needle; D004252:DNA Mutational Analysis; D006801:Humans; D018208:Liposarcoma, Myxoid / Q000175:diagnosis / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D010306:Parotid Gland / Q000473:pathology*; D015203:Reproducibility of Results; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012468:Salivary Gland Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology / Q000556:secondary*