title: Hippocampal novelty activations in schizophrenia: disease and medication effects.
abstract: We examined hippocampal activation in schizophrenia (SZ) with fMRI BOLD in response to the presentation of novel and familiar scenes. Voxel-wise analysis showed no group differences. However, anatomical region-of-interest analyses contrasting normal (NL), SZ-on-medication (SZ-ON), SZ-off-medication (SZ-OFF) showed substantial differences in MTL-based novelty responding, accounted for by the reduction in novelty responses in the SZ-OFF predominantly in the anterior hippocampus and parahippocampal cortex. These differences in novelty-based activation in the SZ-OFF group represent disease characteristics of schizophrenia without confounding effects of antipsychotic medication and illustrate the tendency of antipsychotic drug treatment to improve memory functions in schizophrenia.
authors.affiliation: Department of Psychiatry, University of Texas Southwestern Medical School, Dallas, TX, United States. Carol.tamminga@utsouthwestern.edu
authors.forename: Carol A
authors.initials: CA
authors.lastname: Tamminga
authors.forename: Binu P
authors.initials: BP
authors.lastname: Thomas
authors.forename: Ronald
authors.initials: R
authors.lastname: Chin
authors.forename: Perry
authors.initials: P
authors.lastname: Mihalakos
authors.forename: Kenneth
authors.initials: K
authors.lastname: Youens
authors.forename: Anthony D
authors.initials: AD
authors.lastname: Wagner
authors.forename: Alison R
authors.initials: AR
authors.lastname: Preston
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D016022:Case-Control Studies; D005260:Female; D059907:Functional Neuroimaging; D006624:Hippocampus / Q000187:drug effects / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020534:Parahippocampal Gyrus / Q000187:drug effects / Q000503:physiopathology*; D021641:Recognition, Psychology; D012559:Schizophrenia / Q000188:drug therapy / Q000503:physiopathology*
chemical_list: D014150:Antipsychotic Agents