title: [The relation of serum paraoxonase-1 activity with isolated coronary artery ectasia: an observational study].
abstract: OBJECTIVE
  Coronary artery ectasia (CAE) is a congenital or acquired anomaly characterized with localized or diffuse dilatations of coronary arteries. Paraoxonase (PON-1) is a high-density lipoprotein-cholesterol (HDLC) associated antioxidant enzyme that prevents atherosclerosis. The aim of this study was to investigate serum paraoxonase-1 enzyme activity (SPA) in patients with CAE in comparison patients with coronary artery disease (CAD) and normal coronary arteries.
  
  
  METHODS
  We have evaluated 44 patients with isolated IKAE, 40 cases with normal coronary arteries (NCA), 40 cases with critical CAD (CAD) and 40 cases with minimal CAD (MCAD) in this cross-sectional observational study. Demographic and biochemical data of patients were collected. SPA was determined spectrophotometrically. Among-group comparisons, ANOVA, Kruskal-Wallis and Chi-square tests were used; Bonferroni test was used for post-hoc analysis, Pearson's correlation analysis to determine the parameters associated with the SPA.
  
  
  RESULTS
  There were no differences among groups with regard to age, sex, presence of diabetes, hypertension and smoking (p>0.05 for all). The highest HDLC was detected in patients with NCA and lowest HDLC was detected in patients with CAD (respectively 52±15 mg/dL; 41±16 mg/d L, p=0.021). CAD and CAE groups were similar with respect to HDLC levels (p>0.05). The highest SPA level was detected in patients with NKA and the lowest SPA level was detected in patients with CAD (respectively 250.78±59.37U/L; 163.39±49.28 U/L, p=0.005). CAD and CAE groups were similar with respect to SPA levels (p>0.05).
  
  
  CONCLUSIONS
  Both decreased SPA and decreased HDLC levels are closely related to the development of the CAE similar to CAD.
authors.affiliation: Şanlıurfa Eğitim ve Araştırma Hastanesi, Kardiyoloji Kliniği, Şanlıurfa, Turkey. ihaltiparmak@gmail.com
authors.forename: Ibrahim Halil
authors.initials: IH
authors.lastname: Altıparmak
authors.forename: Zekeriya
authors.initials: Z
authors.lastname: Kaya
authors.forename: Hatice
authors.initials: H
authors.lastname: Sezen
authors.forename: Mehmet Salih
authors.initials: MS
authors.lastname: Aydın
authors.forename: Recep
authors.initials: R
authors.lastname: Demirbağ
authors.forename: Nurten
authors.initials: N
authors.lastname: Aksoy
mesh_terms: D000368:Aged; D043303:Aryldialkylphosphatase / Q000097:blood*; D003324:Coronary Artery Disease / Q000097:blood / Q000201:enzymology* / Q000473:pathology; D003331:Coronary Vessels / Q000473:pathology*; D003430:Cross-Sectional Studies; D004108:Dilatation, Pathologic / Q000097:blood / Q000201:enzymology* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D043303:Aryldialkylphosphatase