title: Synthesis and herbicidal activity evaluation of novel β-carboline derivatives.
abstract: Based on the original structure of harmine, several novel 1,2,3,4-tetrahydro-β-carboline, β-carboline and 1-substituted-β-carboline derivatives bearing a substituted carbohydrazide group at C-3 were designed and synthesized to investigate the structure-activity relationship of their analogues. All of the compounds were characterized by infrared (IR), proton and carbon nuclear magnetic resonance (1H-NMR, 13C-NMR), and mass spectroscopy (MS). The bioassay tests showed that N'-benzylidene-1-phenyl-β-carboline-3-carbohydrazide (C(25)H(18)N(4)O, m.w. 390.4) (c2) and N'-(4-trifluoromethyl-benzylidene)-1-phenyl-β-carboline-3-carbohydrazide (C(26)H(17)N(4)OF(3), m.w. 458) (d2) exhibited good inhibitory activity against dicotyledonous and monocotyledonous weeds, with EC(50) values of 4.83 µM and 14.25 µM, respectively.
authors.affiliation: Key Laboratory of Pesticide and Chemical Biology, Ministry of Education,Guangzhou 510642, China. huabao@scau.edu.cn
authors.forename: Qunfang
authors.initials: Q
authors.lastname: Weng
authors.forename: Jingfei
authors.initials: J
authors.lastname: Huang
authors.forename: Yong
authors.initials: Y
authors.lastname: Zeng
authors.forename: Yueye
authors.initials: Y
authors.lastname: Deng
authors.forename: Meiying
authors.initials: M
authors.lastname: Hu
mesh_terms: D002243:Carbolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D006247:Harmine / Q000737:chemistry; D006540:Herbicides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D002243:Carbolines; D006540:Herbicides; D006247:Harmine