title: Radiobiologically guided optimisation of the prescription dose and fractionation scheme in radiotherapy using BioSuite.
abstract: OBJECTIVE
  Radiobiological models provide a means of evaluating treatment plans. Keeping in mind their inherent limitations, they can also be used prospectively to design new treatment strategies which maximise therapeutic ratio. We propose here a new method to customise fractionation and prescription dose.
  
  
  METHODS
  To illustrate our new approach, two non-small cell lung cancer treatment plans and one prostate plan from our archive are analysed using the in-house software tool BioSuite. BioSuite computes normal tissue complication probability and tumour control probability using various radiobiological models and can suggest radiobiologically optimal prescription doses and fractionation schemes with limited toxicity.
  
  
  RESULTS
  Dose-response curves present varied aspects depending on the nature of each case. The optimisation process suggests doses and fractionation schemes differing from the original ones. Patterns of optimisation depend on the degree of conformality, the behaviour of the normal tissue (i.e. "serial" or "parallel"), the volume of the tumour and the parameters of clonogen proliferation.
  
  
  CONCLUSIONS
  Individualising the prescription dose and number of fractions with the help of BioSuite results in improved therapeutic ratios as evaluated by radiobiological models.
authors.affiliation: Physics Department, Clatterbridge Cancer Centre, Bebington, UK. Julien.Uzan@clatterbridgecc.nhs.uk
authors.forename: J
authors.initials: J
authors.lastname: Uzan
authors.forename: A E
authors.initials: AE
authors.lastname: Nahum
mesh_terms: D003198:Computer Simulation; D019583:Dose Fractionation, Radiation; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000532:radiotherapy*; D011859:Radiography; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D061089:Radiotherapy, Image-Guided / Q000379:methods*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012984:Software