title: Large granular lymphocyte leukemia as a complication of rheumatoid arthritis.
abstract: Large granular lymphocyte leukemia is a rare entity belonging to same spectrum of diseases than Felty's syndrome, which might occur in patients with long-standing rheumatoid arthritis. It is clinically characterized by persistent neutropenia and recurrent bacterial infections associated with the presence in both peripheral blood and bone marrow of clonal expansion of atypic lymphocytes with a cytotoxic T cell phenotype, or less frequently an NK-cell phenotype, as well as splenomegaly. It is more frequently diagnosed in seropositive rheumatoid arthritis, with significant structural damage, extra-articular manifestations and persistently elevated values of ESR, despite them havubg low inflammatory joint activity. We report the case of a 70 year old male with a long-standing rheumatoid arthritis, who developed septic shock secondary to prosthetic hip infection by Salmonella spp. He showed persistent neutropenia, and an aberrant monoclonal T cell population was detected in both peripheral blood and bone marrow, consistent with large granular lymphocyte leukemia.
authors.affiliation: Servicio de Reumatología, Hospital Universitario Ramón y Cajal, Madrid, España. aloisiglesias@gmail.com
authors.forename: Ana
authors.initials: A
authors.lastname: Lois Iglesias
authors.forename: Walter Alberto
authors.initials: WA
authors.lastname: Sifuentes Giraldo
authors.forename: Javier
authors.initials: J
authors.lastname: Bachiller Corral
authors.forename: Ana
authors.initials: A
authors.lastname: Saiz González
authors.forename: Elia
authors.initials: E
authors.lastname: Brito Brito
authors.forename: Antonio
authors.initials: A
authors.lastname: Zea Mendoza
mesh_terms: D000368:Aged; D001172:Arthritis, Rheumatoid / Q000150:complications*; D006801:Humans; D054066:Leukemia, Large Granular Lymphocytic / Q000175:diagnosis* / Q000209:etiology; D008297:Male