title: One-pot aqueous phase growth of biocompatible 15-130 nm gold nanoparticles stabilized with bidentate PEG.
abstract: We describe a new, single pot, aqueous phase method for synthesizing water soluble gold nanoparticles (AuNPs) over a size range of 15-130 nm. Poly(ethylene glycol)-appended thioctic acid ligands were used to control the growth rates and stabilize the AuNPs. Critical factors that enable the controlled growth of the AuNPs over this size range include the pH, the choice of reducing agent, the reaction temperature and the sequential addition of gold precursor and ligand with specific ligand-to-gold ratios. We describe the synthetic procedure in detail. Optical and structural characterization of the AuNPs was accomplished using UV-vis absorption spectroscopy, dynamic light scattering, and transmission and scanning electron microscopy.
authors.affiliation: US Naval Research Laboratory, Optical Sciences Division, Washington, DC 20375, USA. eunkeuoh@ccs.nrl.navy.mil
authors.forename: Eunkeu
authors.initials: E
authors.lastname: Oh
authors.forename: Kimihiro
authors.initials: K
authors.lastname: Susumu
authors.forename: Vaibhav
authors.initials: V
authors.lastname: Jain
authors.forename: Mijin
authors.initials: M
authors.lastname: Kim
authors.forename: Alan
authors.initials: A
authors.lastname: Huston
mesh_terms: D001672:Biocompatible Materials / Q000737:chemistry*; D006046:Gold / Q000737:chemistry*; D008024:Ligands; D053758:Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D036103:Nanotechnology / Q000379:methods*; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry*; D019163:Reducing Agents / Q000737:chemistry; D013696:Temperature; D014867:Water / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D008024:Ligands; D019163:Reducing Agents; D014867:Water; D011092:Polyethylene Glycols; D006046:Gold