title: M2 protein from influenza A: from multiple structures to biophysical and functional insights.
abstract: The M2 protein from influenza A is a proton channel as a tetramer, with a single transmembrane helix from each monomer lining the pore. Val27 and Trp41 form gates at either end of the pore and His37 mediates the shuttling of protons across a central barrier between the N-terminal and C-terminal aqueous pore regions. Numerous structures of this transmembrane domain and of a longer construct that includes an amphipathic helix are now in the Protein Data Bank. Many structural differences are apparent from samples obtained in a variety of membrane mimetic environments. High-resolution structural results in lipid bilayers have provided novel insights into the functional mechanism of the unique HxxxW cluster in the M2 proton channel.
authors.affiliation: Department of Chemistry and Biochemistry, Florida State University, Tallahassee, FL 32306, United States. cross@magnet.fsu.edu
authors.forename: Timothy A
authors.initials: TA
authors.lastname: Cross
authors.forename: Hao
authors.initials: H
authors.lastname: Dong
authors.forename: Mukesh
authors.initials: M
authors.lastname: Sharma
authors.forename: David D
authors.initials: DD
authors.lastname: Busath
authors.forename: Huan-Xiang
authors.initials: HX
authors.lastname: Zhou
mesh_terms: D001703:Biophysics; D006801:Humans; D009980:Influenza A virus / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D007251:Influenza, Human / Q000821:virology*; D014763:Viral Matrix Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D000086082:Viroporin Proteins
chemical_list: D014763:Viral Matrix Proteins; C488937:M2 protein, Influenza A virus; D000086082:Viroporin Proteins