title: [Aging and the control of the insulin-FOXO signaling pathway].
abstract: Aging is a complex process that is accompanied by the onset of a series of age-related diseases, including Alzheimer's disease. Aging is controlled by a combination of genetic and environmental factors. Among the genes that regulate aging, the insulin-FOXO signaling pathway plays a central role, as this pathway regulates lifespan in multiple species, such as worms, flies, and mice. In humans, exceptional longevity - being a centenarian - is also associated with genetic variation in this insulin-FOXO pathway. Recent evidence indicates that the FOXO family of transcription factors plays a key role in the self-renewal of adult and embryonic stem cells, which could contribute to tissue regeneration. Understanding the mechanisms underlying aging should help better prevent and treat age-dependent diseases.
authors.affiliation: Département de génétique, Stanford University, 94305 Stanford, CA, États-Unis. abrunet1@stanford.edu
authors.forename: Anne
authors.initials: A
authors.lastname: Brunet
mesh_terms: D000263:Adenylate Kinase / Q000502:physiology; D000375:Aging / Q000502:physiology*; D000818:Animals; D017173:Caenorhabditis elegans / Q000502:physiology; D031204:Caloric Restriction; D004198:Disease Susceptibility; D004331:Drosophila melanogaster / Q000502:physiology; D005544:Forecasting; D051858:Forkhead Transcription Factors / Q000502:physiology*; D005786:Gene Expression Regulation / Q000235:genetics / Q000502:physiology*; D006801:Humans; D007328:Insulin / Q000502:physiology*; D007334:Insulin-Like Growth Factor I / Q000502:physiology; D008136:Longevity / Q000235:genetics; D051379:Mice; D008954:Models, Biological; D018384:Oxidative Stress; D012038:Regeneration / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D013234:Stem Cells / Q000166:cytology
chemical_list: D051858:Forkhead Transcription Factors; D007328:Insulin; D007334:Insulin-Like Growth Factor I; D000263:Adenylate Kinase