title: Pluripotent stem cell-based cancer therapy: promise and challenges.
abstract: The development of induced pluripotent stem cell (iPSC) technology has generated enthusiasm about the therapeutic potential of these cells for treating a variety of diseases. However, the evidence that they actually will be clinically useful is limited. Here, we discuss the potential therapeutic applications of iPSCs for treating cancer and other diseases and highlight the current barriers restricting their use.
authors.affiliation: Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
authors.forename: Saul J
authors.initials: SJ
authors.lastname: Sharkis
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Jones
authors.forename: Curt
authors.initials: C
authors.lastname: Civin
authors.forename: Yoon-Young
authors.initials: YY
authors.lastname: Jang
mesh_terms: D053687:Adult Stem Cells / Q000166:cytology; D000818:Animals; D019337:Hematologic Neoplasms / Q000628:therapy; D006801:Humans; D009369:Neoplasms / Q000628:therapy*; D039904:Pluripotent Stem Cells / Q000166:cytology*; D033581:Stem Cell Transplantation; D057170:Translational Research, Biomedical