title: Experimental murine model of disseminated infection by Saksenaea vasiformis: successful treatment with posaconazole.
abstract: We have determined the in vitro activity of amphotericin B (AMB) and posaconazole (PSC) against Saksenaea vasiformis using broth microdilution and disk diffusion methods and determined the minimal fungicidal concentration (MFC). PSC was found to have the greatest in vitro activity in all cases and was the most efficacious in prolonging survival and reducing the fungal load in an immunocompetent murine model of disseminated infection caused by four strains of the fungus.
authors.affiliation: Unitat de Microbiologia, Universitat Rovira i Virgili, Reus, Spain.
authors.forename: Valentina
authors.initials: V
authors.lastname: Salas
authors.forename: F Javier
authors.initials: FJ
authors.lastname: Pastor
authors.forename: Enrique
authors.initials: E
authors.lastname: Calvo
authors.forename: Deanna
authors.initials: D
authors.lastname: Sutton
authors.forename: Dea
authors.initials: D
authors.lastname: García-Hermoso
authors.forename: Emilio
authors.initials: E
authors.lastname: Mayayo
authors.forename: Françoise
authors.initials: F
authors.lastname: Dromer
authors.forename: Anette
authors.initials: A
authors.lastname: Fothergill
authors.forename: Eduardo
authors.initials: E
authors.lastname: Alvarez
authors.forename: Josep
authors.initials: J
authors.lastname: Guarro
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D009090:Mucorales / Q000472:pathogenicity*; D009091:Mucormycosis / Q000188:drug therapy* / Q000382:microbiology* / Q000473:pathology*; D016896:Treatment Outcome; D014230:Triazoles / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000935:Antifungal Agents; D014230:Triazoles; C101425:posaconazole; D000666:Amphotericin B