title: Susceptibility to cervical cancer: an overview.
abstract: Cervical cancer is the second most common cancer in females worldwide. It is well-established that Human Papillomavirus (HPV) infections play a critical role in the development of cervical cancer. However, a large number of women infected with oncogenic HPV types will never develop cervical cancer. Thus, there are several external environment and genetic factors involved in the progression of a precancerous lesion to invasive cancer. In this review article, we addressed possible susceptible phenotypes to cervical cancer, focusing on host genome and HPV DNA variability, multiple HPV infections, co-infection with other agents, circulating HPV DNA and lifestyle.
authors.affiliation: Laboratory of Molecular Studies and Experimental Therapy, Department of Genetics, Center for Biological Sciences, Federal University of Pernambuco, Recife, Brazil. acf_ufpe@yahoo.com.br
authors.forename: Antonio Carlos
authors.initials: AC
authors.lastname: de Freitas
authors.forename: Ana Pavla Almeida Diniz
authors.initials: AP
authors.lastname: Gurgel
authors.forename: Bárbara Simas
authors.initials: BS
authors.lastname: Chagas
authors.forename: Eliane Campos
authors.initials: EC
authors.lastname: Coimbra
authors.forename: Carolina Maria Medeiros
authors.initials: CM
authors.lastname: do Amaral
mesh_terms: D018450:Disease Progression; D005260:Female; D006801:Humans; D027383:Papillomaviridae / Q000235:genetics; D030361:Papillomavirus Infections / Q000150:complications / Q000235:genetics / Q000821:virology; D012307:Risk Factors; D002583:Uterine Cervical Neoplasms / Q000209:etiology* / Q000235:genetics / Q000473:pathology / Q000821:virology