title: Novel human umbilical vein endothelial cells (HUVEC)-apoptosis inhibitory phytosterol analogues: insight into their structure-activity relationships.
abstract: Design, synthesis and insight into the structure-activity relationships (SAR) of phytosterol analogues as novel antiapoptotic agents are described. In particular, the non-branched alkyl chain at C24 and the pseudosugar moiety at C3 hydroxyl group turned out crucial for the inhibition of human umbilical vein endothelial cells (HUVEC) apoptosis.
authors.affiliation: College of Pharmacy, Seoul National University, Seoul 151-742, Korea.
authors.forename: Sujin
authors.initials: S
authors.lastname: Lee
authors.forename: Sony
authors.initials: S
authors.lastname: Marharjan
authors.forename: Jong-Wha
authors.initials: JW
authors.lastname: Jung
authors.forename: Nam-Jung
authors.initials: NJ
authors.lastname: Kim
authors.forename: Kyeojin
authors.initials: K
authors.lastname: Kim
authors.forename: Young Taek
authors.initials: YT
authors.lastname: Han
authors.forename: Changjin
authors.initials: C
authors.lastname: Lim
authors.forename: Hyun-Jung
authors.initials: HJ
authors.lastname: Choi
authors.forename: Young-Geun
authors.initials: YG
authors.lastname: Kwon
authors.forename: Young-Ger
authors.initials: YG
authors.lastname: Suh
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D061307:Human Umbilical Vein Endothelial Cells / Q000187:drug effects* / Q000473:pathology; D006801:Humans; D006865:Hydrogenation; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010840:Phytosterols / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D010840:Phytosterols