title: The T29C polymorphism of the transforming growth factor-β1 (TGF-β1) gene is associated with genetic susceptibility to acute coronary syndrome in Mexican patients.
abstract: Inflammation plays an essential role in the development and progression of atherosclerotic lesions, and plaque disruption. The TGF-β1 plays an important role in the anti-inflammatory process. The aim of the present study was to evaluate the role of TGF-β1 gene polymorphisms as susceptibility markers for acute coronary syndrome (ACS). Two polymorphisms (TGF-β -509T>C and TGF-β T29C) of the TGF-β gene were analyzed by 5' exonuclease TaqMan genotyping assays in a group of 426 patients with coronary acute syndrome and 551 healthy unrelated controls. A significant difference was observed in the distribution of TGF-β T29C polymorphism between ACS patients and healthy controls (P<10(-3)). According to the co-dominant model, individuals with the TGF-β 29 TT genotype have a 2.5-fold increased risk of developing ACS (P<10(-3)). Multiple logistic analysis showed that the largest risk factor for developing ACS was given by smoking habit, diabetes, hypertension, dyslipidemia, and the TGF-β1 29 TT genotype. The analysis of linkage disequilibrium showed one haplotype (TT) with increased frequency and one haplotype (CC) with decreased frequency in ACS patients when compared to healthy controls. The results suggest that TGF-β1 T29C gene polymorphism could be involved in the risk of developing ACS in Mexican individuals.
authors.affiliation: Department of Molecular Biology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico. mfragoso1275@yahoo.com.mx
authors.forename: José Manuel
authors.initials: JM
authors.lastname: Fragoso
authors.forename: Marco Antonio
authors.initials: MA
authors.lastname: Martínez-Ríos
authors.forename: Edith
authors.initials: E
authors.lastname: Alvarez-León
authors.forename: Maite
authors.initials: M
authors.lastname: Vallejo
authors.forename: Marco Antonio
authors.initials: MA
authors.lastname: Peña-Duque
authors.forename: Rosalinda
authors.initials: R
authors.lastname: Posadas-Sánchez
authors.forename: Carlos
authors.initials: C
authors.lastname: Posadas-Romero
authors.forename: Janette
authors.initials: J
authors.lastname: Furuzawa-Carballeda
authors.forename: Guadalupe
authors.initials: G
authors.lastname: Lima
authors.forename: Luis
authors.initials: L
authors.lastname: Llorente
authors.forename: Gilberto
authors.initials: G
authors.lastname: Vargas-Alarcón
mesh_terms: D054058:Acute Coronary Syndrome / Q000235:genetics*; D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D011110:Polymorphism, Genetic; D020133:Reverse Transcriptase Polymerase Chain Reaction; D053773:Transforming Growth Factor beta1 / Q000235:genetics*
chemical_list: D053773:Transforming Growth Factor beta1