title: Angiotensin receptor blockers and tumorigenesis: something to be (or not to be) concerned about?
abstract: The possibility of carcinogenic side effects of antihypertensive therapies due to their chronic administration has been raised multiple times in the past. Recently, the issue has again drawn attention, this time in relation to angiotensin receptor blockers (ARBs). This, among others, caused both American and European drug regulation authorities to review the underlying evidence concerning the relationship between this class of medications and potential adverse carcinogenic outcome. A plethora of both basic science and preclinical evidence has been generated, and three meta-analyses and one nationwide cohort have focused on this specific question. The current review aims to summarize the contemporary multidisciplinary evidence on whether ARBs may be associated with an increased risk of tumorigenesis.
authors.affiliation: Haemostasis, Thrombosis and Vascular Biology Unit, University of Birmingham Centre for Cardiovascular Sciences, City Hospital Birmingham, Birmingham, B18 7QH, England, UK.
authors.forename: Vadim
authors.initials: V
authors.lastname: Tchaikovski
authors.forename: Gregory Y H
authors.initials: GY
authors.lastname: Lip
mesh_terms: D057911:Angiotensin Receptor Antagonists / Q000009:adverse effects*; D000959:Antihypertensive Agents / Q000009:adverse effects*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D006801:Humans; D008175:Lung Neoplasms / Q000139:chemically induced; D009369:Neoplasms / Q000139:chemically induced*; D012307:Risk Factors
chemical_list: D057911:Angiotensin Receptor Antagonists; D000959:Antihypertensive Agents