title: Aripiprazole salts. I. Aripiprazole nitrate.
abstract: The crystal structure of aripiprazole nitrate (systematic name: 4-(2,3-dichlorophenyl)-1-{4-[(2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)oxy]butyl}piperazin-1-ium nitrate), C(23)H(28)Cl(2)N(3)O(2)(+)·NO(3)(-) or AripH(+)·NO(3)(-), is presented and the molecule compared with the aripiprazole molecules reported so far in the literature. Bond distances and angles appear very similar, except for a slight lengthening of the C-NH distances involving the protonated N atom, and the main differences are to be found in the molecular spatial arrangement (revealed by the sequence of torsion angles) and the intermolecular interactions (resulting from structural elements specific to this structure, viz. the nitrate counter-ions on one hand and the extra protons on the other hand as hydrogen-bond acceptors and donors, respectively). The result is the formation of [100] strips, laterally linked by weak π-π and C-Cl...π interactions, leading to a family of undulating sheets parallel to (010).
authors.affiliation: Gerencia de Investigación y Aplicaciones, Comisión Nacional de Energía Atómica and Escuela de Ciencia y Tecnología, Universidad Nacional General San Martín, Buenos Aires, Argentina. freire@tandar.cnea.gov.ar
authors.forename: Eleonora
authors.initials: E
authors.lastname: Freire
authors.forename: Griselda
authors.initials: G
authors.lastname: Polla
authors.forename: Ricardo
authors.initials: R
authors.lastname: Baggio