title: Phenomenological analysis of ATP dependence of motor proteins.
abstract: In this study, through phenomenological comparison of the velocity-force data of processive motor proteins, including conventional kinesin, cytoplasmic dynein and myosin V, I found that, the ratio between motor velocities of two different ATP concentrations is almost invariant for any substall, superstall or negative external loads. Therefore, the velocity of motors can be well approximated by a Michaelis-Menten like formula V = [ATP]k(F)L([ATP] + K(M)), with L the step size, and k(F) the external load F dependent rate of one mechanochemical cycle of motor motion in saturated ATP solution. The difference of Michaelis-Menten constant K(M) for substall, superstall and negative external load indicates, the configurations at which ATP molecule can bind to motor heads for these three cases might be different, though the expression of k(F) as a function of F might be unchanged for any external load F. Verifications of this Michaelis-Menten like formula has also been done by fitting to the recent experimental data.
authors.affiliation: Laboratory of Mathematics for Nonlinear Science, Shanghai Key Laboratory for Contemporary Applied Mathematics, Centre for Computational Systems Biology, School of Mathematical Sciences, Fudan University, Shanghai, China. xyz@fudan.edu.cn
authors.forename: Yunxin
authors.initials: Y
authors.lastname: Zhang
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism*; D004398:Dyneins / Q000378:metabolism; D007700:Kinetics; D020409:Molecular Motor Proteins / Q000378:metabolism*; D024701:Myosin Type V / Q000378:metabolism
chemical_list: D020409:Molecular Motor Proteins; D000255:Adenosine Triphosphate; D024701:Myosin Type V; D004398:Dyneins