title: Recurrent pregnancy loss and thrombophilia.
abstract: Emerging data seem to be available also on the role of active thromboprophylaxis with heparin and pregnancy outcome. In the last decades we found many data concerning the association between a hypercoagulable state and its causes and adverse pregnancy outcome, in particular recurrent pregnancy loss (RPL). First studies which focused on the association between thrombophilia and RPL underlined the role of reduced clotting inhibitors and RPL, and subsequent studies underlined a pathogenetic role of gene variant associated to hypercoagulable state in the occurrence of RPL. On the other hand, acquired thrombophilic abnormalities as antiphipsholipid syndrome are a well known cause of RPL and should be considered for a screening. These data are relevant because recent studies suggested a role of an extensive thromprophilaxis in women with RPL that should be addressed only in case of known thrombophilia and high risk of venous thromboembolism.
  
  
  BACKGROUND
  Thrombophilia; Recurrent pregnancy loss; Factor V Leiden; Hyperhomocysteinemia; Antiphospholipid antibodies; PAI 4G\4G.
authors.affiliation: Department of Obstetrics and Gynecology and Human Reproduction, Federico II University of Naples, Naples, Italy.
authors.forename: Maristella
authors.initials: M
authors.lastname: D'Uva
authors.forename: Pierpaolo Di
authors.initials: PD
authors.lastname: Micco
authors.forename: Ida
authors.initials: I
authors.lastname: Strina
authors.forename: Giuseppe De
authors.initials: GD
authors.lastname: Placido