title: α-Synuclein BAC transgenic mice as a model for Parkinson's disease manifested decreased anxiety-like behavior and hyperlocomotion.
abstract: α-Synuclein (α-syn), the main component of Lewy bodies, was identified as a genetic risk factor for idiopathic Parkinson's disease (PD). As a model for PD, we generated human α-syn bacterial artificial chromosome transgenic mice (BAC tg mice) harboring the entire human α-syn gene and its gene expression regulatory regions. The α-syn BAC tg mice manifested decreased anxiety-like behaviors which may reflect non-motor symptoms of early PD, and they exhibited increased SERT expression that may be responsible for decreased anxiety-like behaviors. Our α-syn BAC tg mice could be a valuable tool to evaluate α-syn gene dosage effects in vivo.
authors.affiliation: Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
authors.forename: Hodaka
authors.initials: H
authors.lastname: Yamakado
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Moriwaki
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Yamasaki
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Miyakawa
authors.forename: Junko
authors.initials: J
authors.lastname: Kurisu
authors.forename: Kengo
authors.initials: K
authors.lastname: Uemura
authors.forename: Haruhisa
authors.initials: H
authors.lastname: Inoue
authors.forename: Makio
authors.initials: M
authors.lastname: Takahashi
authors.forename: Ryosuke
authors.initials: R
authors.lastname: Takahashi
mesh_terms: D000818:Animals; D001007:Anxiety / Q000235:genetics* / Q000517:prevention & control / Q000523:psychology; D022202:Chromosomes, Artificial, Bacterial / Q000235:genetics* / Q000378:metabolism; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D009043:Motor Activity / Q000235:genetics; D010300:Parkinson Disease / Q000235:genetics* / Q000378:metabolism / Q000523:psychology; D011595:Psychomotor Agitation / Q000235:genetics* / Q000378:metabolism / Q000523:psychology; D051844:alpha-Synuclein / Q000096:biosynthesis / Q000235:genetics*
chemical_list: D051844:alpha-Synuclein