title: Double-blind, within-patient, randomized, clinical trial comparing fluorine-synthetic fiber socks with standard cotton socks in improving plantar psoriasis.
abstract: BACKGROUND
  Rubbing the skin and trauma may influence the persistence of psoriasis over time.
  
  
  OBJECTIVE
  To assess the impact of a new fabric made with a special fluorine-synthetic fiber in improving plantar psoriasis.
  
  
  METHODS
  A total of 20 patients with symmetrical lesions were randomized to receive on one side a sock made of fluorine-synthetic fiber and on the other side a sock made of cotton fabric for 4 weeks. The main outcome was the percentage reduction of lesional area.
  
  
  RESULTS
  In an intention-to-treat analysis, the median lesion reduction was 11.95% in fluorine-synthetic fiber arm and 11.89% in cotton arm (p = 0.776). Among secondary outcomes, patient global satisfaction showed a statistically significant median score of 32 toward fluorine-synthetic fiber arm (p = 0.011).
  
  
  CONCLUSIONS
  In spite of our main negative results, it is important to continue investigating on the relation between textiles and skin disorders to improve patient well-being.
authors.affiliation: Centro Studi GISED, Fondazione per la Ricerca Ospedale Maggiore , Bergamo , Italy.
authors.forename: Simone
authors.initials: S
authors.lastname: Cazzaniga
authors.forename: Giovanni
authors.initials: G
authors.lastname: Lo Scocco
authors.forename: Emiliano
authors.initials: E
authors.lastname: Schincaglia
authors.forename: Santo Raffaele
authors.initials: SR
authors.lastname: Mercuri
authors.forename: Sergio
authors.initials: S
authors.lastname: Chimenti
authors.forename: Rosita
authors.initials: R
authors.lastname: Saraceno
authors.forename: Luigi
authors.initials: L
authors.lastname: Naldi
mesh_terms: D000328:Adult; D003020:Clothing; D032561:Cotton Fiber; D004311:Double-Blind Method; D005260:Female; D005461:Fluorine / Q000627:therapeutic use; D017611:Fluorine Compounds; D005533:Foot Dermatoses / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D011565:Psoriasis / Q000473:pathology / Q000628:therapy*; D013784:Textiles; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D017611:Fluorine Compounds; D005461:Fluorine