title: Modification of sulpiride model of benign prostatic hyperplasia for evaluation of the effectiveness of drug therapy.
abstract: Specific effects of ultra-low doses of antibodies to prostate-specific antigen obtained from laboratory rats of late reproductive age with sulpiride model of benign prostatic hyperplasia were compared with the results of clinical application of the preparation. Clinical reproducibility of experimental data was proven, which suggests that the developed model is adequate for pilot testing of the effects of pharmacotherapy of this disease.
authors.affiliation: Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia. igdoca@mail.ru
authors.forename: T G
authors.initials: TG
authors.lastname: Borovskaja
authors.forename: S A
authors.initials: SA
authors.lastname: Sergeeva
authors.forename: V V
authors.initials: VV
authors.lastname: Udut
authors.forename: T I
authors.initials: TI
authors.lastname: Fomina
authors.forename: Z A
authors.initials: ZA
authors.lastname: Jurmazov
authors.forename: A V
authors.initials: AV
authors.lastname: Pahomova
authors.forename: M E
authors.initials: ME
authors.lastname: Poluektova
authors.forename: J A
authors.initials: JA
authors.lastname: Chemerova
authors.forename: O A
authors.initials: OA
authors.lastname: Rumpel'
mesh_terms: D000818:Animals; D000906:Antibodies / Q000008:administration & dosage* / Q000627:therapeutic use; D004195:Disease Models, Animal; D004354:Drug Screening Assays, Antitumor / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011467:Prostate / Q000187:drug effects / Q000473:pathology; D017430:Prostate-Specific Antigen / Q000276:immunology; D011470:Prostatic Hyperplasia / Q000139:chemically induced* / Q000188:drug therapy* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar; D018709:Statistics, Nonparametric; D013469:Sulpiride; D016896:Treatment Outcome
chemical_list: D000906:Antibodies; D013469:Sulpiride; D017430:Prostate-Specific Antigen