title: Enterobacteriaceae producing the KPC-2 carbapenemase from hospital sewage.
abstract: Fifteen isolates with reduced susceptibility to meropenem were obtained from hospital sewage. They contained bla(KPC-2) and belonged to multiple clones of Citrobacter freundii or Enterobacter cloacae. bla(KPC-2) was commonly carried by self-transmissible plasmids with different EcoRI-restricted patterns. Tn2 was identified upstream of bla(KPC-2), while ISKpn6 lay downstream. Hospital sewage could be an important reservoir of bla(KPC-2) and warrants more studies.
authors.affiliation: Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China.
authors.forename: Xinzhuo
authors.initials: X
authors.lastname: Zhang
authors.forename: Xiaoju
authors.initials: X
authors.lastname: Lü
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Zong
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000096:biosynthesis* / Q000235:genetics; D016971:Citrobacter freundii / Q000187:drug effects / Q000201:enzymology / Q000235:genetics / Q000302:isolation & purification*; D024881:Drug Resistance, Bacterial; D016972:Enterobacter cloacae / Q000187:drug effects / Q000201:enzymology / Q000235:genetics / Q000302:isolation & purification*; D006761:Hospitals; D000077731:Meropenem; D012722:Sewage / Q000382:microbiology*; D013845:Thienamycins / Q000494:pharmacology; D001618:beta-Lactamases / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D012722:Sewage; D013845:Thienamycins; C491478:beta-lactamase KPC-2; D001618:beta-Lactamases; D000077731:Meropenem