title: The relationship between rebleeding after spontaneous SAH and APOE polymorphisms in a Chinese population.
abstract: Rebleeding leads to lots of patients' disability and mortality after spontaneous subarachnoid hemorrhage (SAH), but the risk factors of rebleeding have not been fully understood. More evidence showed apolipoprotein E (apoE protein, APOE gene) influenced the outcome of spontaneous SAH. In this study, we aimed to investigate the relationship of APOE polymorphisms with rebleeding after spontaneous SAH. A total of 185 patients with spontaneous SAH were involved in the current study. Genomic DNA was extracted from venous blood samples to identify the APOE genotype by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Rebleeding was defined as acute clinical deterioration that was accompanied by computed tomography (CT) evidence of rebleeding in the subarachnoid space. A total of 21 patients occurred rebleeding in 185 patients with spontaneous SAH in the hospital. Data were analyzed by χ(2)-test and logistic regression analyses. The statistical analysis indicated no significant association between APOE genotype and rebleeding in a Chinese population.
authors.affiliation: Department of Neurosurgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, PR China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Yin
authors.forename: Jian
authors.initials: J
authors.lastname: Ruan
authors.forename: Li
authors.initials: L
authors.lastname: Jiang
authors.forename: Shuai
authors.initials: S
authors.lastname: Zhou
authors.forename: Xiaochuan
authors.initials: X
authors.lastname: Sun
mesh_terms: D000367:Age Factors; D000368:Aged; D001057:Apolipoproteins E / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D016009:Chi-Square Distribution; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length / Q000235:genetics*; D012008:Recurrence; D012307:Risk Factors; D013345:Subarachnoid Hemorrhage / Q000000981:diagnostic imaging / Q000235:genetics*; D013346:Subarachnoid Space / Q000000981:diagnostic imaging / Q000503:physiopathology; D014057:Tomography, X-Ray Computed
chemical_list: D001057:Apolipoproteins E