title: Phospholipase D and mTORC1: nutrients are what bring them together.
abstract: Mammalian target of rapamycin (mTOR) complex 1 (mTORC1) plays a central role in translating nutrient abundance into cell growth and proliferation. Although specific proteins have been described as mediators of this nutrient input, their mechanistic linkage remains incomplete. Two studies have added phospholipase D (PLD) as a mediator of nutrients to mTORC1. Furthermore, these studies link PLD and its product phosphatidic acid to previously identified activators of mTORC1 signaling, including the class III phosphoinositide-3 kinase, and provide evidence of the existence of two parallel nutrient-regulated pathways that converge on mTORC1 at late endosomes and/or lysosomes.
authors.affiliation: Department of Internal Medicine, Division of Hematology/Oncology, Metabolic Diseases Institute, University of Cincinnati, Cincinnati, OH 45237, USA.
authors.forename: Brian M
authors.initials: BM
authors.lastname: Wiczer
authors.forename: George
authors.initials: G
authors.lastname: Thomas
mesh_terms: D000818:Animals; D058546:Class III Phosphatidylinositol 3-Kinases / Q000378:metabolism; D006801:Humans; D000076222:Mechanistic Target of Rapamycin Complex 1; D008954:Models, Biological; D046912:Multiprotein Complexes / Q000378:metabolism; D009747:Nutritional Physiological Phenomena; D010739:Phospholipase D / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: C500984:CRTC1 protein, human; D046912:Multiprotein Complexes; D011506:Proteins; D014157:Transcription Factors; C546842:MTOR protein, human; D058546:Class III Phosphatidylinositol 3-Kinases; D000076222:Mechanistic Target of Rapamycin Complex 1; D058570:TOR Serine-Threonine Kinases; D010739:Phospholipase D; C106801:phospholipase D1