title: Renal manifestations of primary hyperparathyroidism.
abstract: Primary hyperparathyroidism (PHPT) is associated with nephrolithiasis and nephrocalcinosis. Hypercalciuria is one of the multiple factors that is implicated in the complex pathophysiology of stone formation. The presence of a renal stone (symptomatic or asymptomatic) categorizes PHPT as symptomatic and is an indication for parathyroid adenomectomy. Progression of nephrocalcinosis is largely reversible after successful surgery, but the residual risk persists. PHPT is also associated with declining renal function. In case of asymptomatic mild PHPT, annual renal functional assessment is advised. Guidelines suggest that an estimated glomerular filtration rate (eGFR) < 60 ml / minute / 1.73 m(2) is an indication for parathyroid adenomectomy. This article discusses how to monitor and manage renal stones and other related renal parameters in case of PHPT.
authors.affiliation: Department of Endocrinology, Seth G. S. Medical College, Parel, Mumbai, India.
authors.forename: Anurag Ranjan
authors.initials: AR
authors.lastname: Lila
authors.forename: Vijaya
authors.initials: V
authors.lastname: Sarathi
authors.forename: Varsha
authors.initials: V
authors.lastname: Jagtap
authors.forename: Tushar
authors.initials: T
authors.lastname: Bandgar
authors.forename: Padma S
authors.initials: PS
authors.lastname: Menon
authors.forename: Nalini Samir
authors.initials: NS
authors.lastname: Shah