title: Design and evaluation of moxifloxacin hydrochloride ocular inserts.
abstract: The objective of the present investigation was to prepare and evaluate ocular inserts of moxifloxacin. An ocular insert was made from an aqueous dispersion of moxifloxacin, sodium alginate, polyvinyl alcohol, and dibutyl phthalate by the film casting method. The ocular insert (5.5 mm diameter) was cross-linked by CaCl2 and was coated with Eudragit S-100, RL-100, RS-100, E-100 or L-100. The in vitro drug drainage/permeation studies were carried out using an all-glass modified Franz diffusion cell. The drug concentration and mucoadhesion time of the ocular insert were found satisfactory. Cross-linking and coating with polymers extended the drainage from inserts. The cross-linked ocular insert coated with Eudragit RL-100 showed maximum drug permeation compared to other formulations.
authors.affiliation: Chitkara College of Pharmacy, Chitkara University, Rajpura, Patiala, Punjab, India. pkpawar80@yahoo.com
authors.forename: Pravin K
authors.initials: PK
authors.lastname: Pawar
authors.forename: Rajesh
authors.initials: R
authors.lastname: Katara
authors.forename: Dipak K
authors.initials: DK
authors.lastname: Majumdar
mesh_terms: D000179:Acrylates / Q000737:chemistry; D000180:Acrylic Resins / Q000737:chemistry; D000268:Adhesiveness; D060433:Administration, Ophthalmic; D000464:Alginates / Q000737:chemistry; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D001372:Aza Compounds / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D002122:Calcium Chloride / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D003315:Cornea / Q000378:metabolism; D003432:Cross-Linking Reagents / Q000737:chemistry; D003993:Dibutyl Phthalate / Q000737:chemistry; D004304:Dosage Forms; D004337:Drug Carriers; D004339:Drug Compounding; D004355:Drug Stability; D024841:Fluoroquinolones; D020723:Glucuronic Acid / Q000737:chemistry; D006041:Goats; D006603:Hexuronic Acids / Q000737:chemistry; D066298:In Vitro Techniques; D000077266:Moxifloxacin; D009092:Mucous Membrane / Q000378:metabolism; D010539:Permeability; D011108:Polymers / Q000737:chemistry*; D011109:Polymethacrylic Acids / Q000737:chemistry; D011142:Polyvinyl Alcohol / Q000737:chemistry; D011804:Quinolines / Q000008:administration & dosage* / Q000737:chemistry / Q000493:pharmacokinetics; D011817:Rabbits; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D000179:Acrylates; D000180:Acrylic Resins; D000464:Alginates; D000890:Anti-Infective Agents; D001372:Aza Compounds; D003432:Cross-Linking Reagents; D004304:Dosage Forms; D004337:Drug Carriers; C477020:Eudragit E100; D024841:Fluoroquinolones; D006603:Hexuronic Acids; D011108:Polymers; D011109:Polymethacrylic Acids; D011804:Quinolines; D003993:Dibutyl Phthalate; C038300:methylmethacrylate-methacrylic acid copolymer; C050528:Eudragit RS; D020723:Glucuronic Acid; D011142:Polyvinyl Alcohol; D002122:Calcium Chloride; D000077266:Moxifloxacin