title: Repeated paired-testing impairs extinction of morphine-induced conditioned place preference dependent on the inter-test interval in rats.
abstract: Using exposure to morphine- and saline-paired sides alternatively as the extinction training procedure, we find that post-retrieval extinction training enhances or hinders the extinction of morphine-induced conditioned place preference (CPP) dependent on the retrieval-extinction training intervals. Here, we examine the influence of post-retrieval extinction training with repeated paired testing on extinction of morphine-induced CPP of rats. Our results demonstrate that paired-testing with a 10-min inter-test interval does not influence the extinction of CPP, while post-retrieval extinction training blocks the extinction of CPP with a 3-h retrieval-extinction interval. These results strongly indicate that the interval between exposure trials influences the outcome of exposure therapy in addiction treatment.
authors.affiliation: Neurobiology Laboratory and State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, Peking University, Beijing 100871, PR China.
authors.forename: Jian-Jun
authors.initials: JJ
authors.lastname: Zhang
authors.forename: Xiang
authors.initials: X
authors.lastname: Ma
authors.forename: Long-Chuan
authors.initials: LC
authors.lastname: Yu
mesh_terms: D000818:Animals; D002755:Choice Behavior / Q000187:drug effects* / Q000502:physiology*; D003213:Conditioning, Psychological / Q000187:drug effects* / Q000502:physiology*; D005108:Extinction, Psychological / Q000187:drug effects* / Q000502:physiology*; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D009020:Morphine