title: Concise synthesis of α-trisubstituted amines from ketones using N-methoxyamines.
abstract: Three-component allylation and cyanation utilizing a ketone and an N-methoxyamine are reported. The high nucleophilicity of the N-methoxyamine and high electrophilicity of the corresponding iminium ion enable the concise synthesis of α-trisubstituted amines in a single step.
authors.affiliation: Department of Applied Chemistry, Faculty of Science and Technology, Keio University, 3-14-1, Hiyoshi, Yokohama 223-8522, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Kurosaki
authors.forename: Kenji
authors.initials: K
authors.lastname: Shirokane
authors.forename: Takeshi
authors.initials: T
authors.lastname: Oishi
authors.forename: Takaaki
authors.initials: T
authors.lastname: Sato
authors.forename: Noritaka
authors.initials: N
authors.lastname: Chida
mesh_terms: D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D007659:Ketones / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D000588:Amines; D007659:Ketones