title: De novo daptomycin-nonsusceptible enterococcal infections.
abstract: Potential emergence of enterococcal daptomycin nonsusceptibility among patients with no prior exposure to daptomycin poses clinical and public health challenges. We found that development of infections with daptomycin-nonsusceptible enterococci in these patients could be associated with sporadic emergence and clonal spread.
authors.affiliation: David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA. tkelesidis@mednet.ucla.edu
authors.forename: Theodoros
authors.initials: T
authors.lastname: Kelesidis
authors.forename: Romney
authors.initials: R
authors.lastname: Humphries
authors.forename: Daniel Z
authors.initials: DZ
authors.lastname: Uslan
authors.forename: David
authors.initials: D
authors.lastname: Pegues
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D017576:Daptomycin / Q000494:pharmacology* / Q000627:therapeutic use; D024901:Drug Resistance, Multiple, Bacterial; D013293:Enterococcus faecalis / Q000187:drug effects* / Q000302:isolation & purification; D016984:Enterococcus faecium / Q000187:drug effects* / Q000302:isolation & purification; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology / Q000401:mortality; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged
chemical_list: D000900:Anti-Bacterial Agents; D017576:Daptomycin