title: THE PAPWORTH PLUG - successful use of high dose fibrinogen concentrate and platelet concentrate in potential life-threatening complication after cardiopulmonary bypass surgery in a patient with Type 2M Vicenza von Willebrand Disease.
abstract: Anecdotally, fibrinogen concentrate (FC) has been used as a "universal" haemostatic agent in complex post-cardiopulmonary bypass (CPB) coagulopathy. We present a case where FC and two pools of platelets prevented life-threatening bleeding in a patient with moderate von Willebrand Disease (vWD) immediately post CPB.
authors.affiliation: Department of Cardiothoracic Surgery, Papworth Hospital, Cambridge, Cambs, UK.
authors.forename: R
authors.initials: R
authors.lastname: Amerikanou
authors.forename: S
authors.initials: S
authors.lastname: MacDonald
authors.forename: K
authors.initials: K
authors.lastname: Lawrence
authors.forename: S
authors.initials: S
authors.lastname: Large
authors.forename: M W
authors.initials: MW
authors.lastname: Besser
mesh_terms: D000368:Aged; D001281:Atrial Fibrillation / Q000601:surgery; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D005340:Fibrinogen / Q000008:administration & dosage*; D006333:Heart Failure / Q000601:surgery; D006801:Humans; D008297:Male; D017713:Platelet Transfusion; D056728:von Willebrand Disease, Type 2
chemical_list: D005340:Fibrinogen