title: The effect of galectin-3 genetic variants on the susceptibility and prognosis of gliomas in a Chinese population.
abstract: The aim of this study is to explore the association between the polymorphisms of galectin-3 gene and clinico-pathological characteristics and prognosis of gliomas. We enrolled 190 histologically diagnosed gliomas and 210 healthy controls in this study. Two genetic variants at galectin-3 single nucleotide polymorphism (SNP) sites (galectin-3 +191 A>C and +292 A>C) were determined. We found that the A/A genotype at galectin-3 gene +292 A>C was significantly more prevalent in gliomas patient than in controls (42.1% vs. 29.0%, P=0.021); the A allele frequency was markedly higher in gliomas subjects than in controls (61.8% vs. 45.0%, P=0.008). There was a markedly higher prevalence of AA carriers in high-grade subgroup than in low-grade subgroup (50.5% vs. 31.8%, P=0.012). The Kaplan-Meier analyses showed that the gliomas patients carrying AA genotype of galectin-3 gene +292 A>C had marked shorter overall survival period than those did not (AA vs. AC+CC, 22.2±3.8 months vs. 38.3 months±7.9; P=0.04). The SNPs at +191 A>C of galectin-3 gene did not show positive association with clinico-pathological characteristics and prognosis of gliomas. The results of this study suggest the SNPs at +292 A>C, not SNPs at +191 A>C, of galectin-3 gene were associated with the tumor grade and prognosis of gliomas.
authors.affiliation: Department of Neurosurgery, Fuzhou General Hospital of Nanjing Command, Fuzhou Fujian 350025, China. neurodrclj@yahoo.com.cn
authors.forename: Hong-jie
authors.initials: HJ
authors.lastname: Chen
authors.forename: Zhao-cong
authors.initials: ZC
authors.lastname: Zheng
authors.forename: Bang-qing
authors.initials: BQ
authors.lastname: Yuan
authors.forename: Zheng
authors.initials: Z
authors.lastname: Liu
authors.forename: Junjie
authors.initials: J
authors.lastname: Jing
authors.forename: Shou-Sen
authors.initials: SS
authors.lastname: Wang
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D005260:Female; D037502:Galectin 3 / Q000032:analysis / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D005910:Glioma / Q000175:diagnosis / Q000235:genetics* / Q000401:mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis
chemical_list: D037502:Galectin 3