title: [The diversity of aging models].
abstract: Most of the signalling pathways involved in aging regulation have been recently found well conserved at various levels throughout the evolution. Taking this into account, a diversity of model organisms, including worms, rodents, and lemurs as well, allows to address different questions: how to understand the interactions between genetic and environmental factors while challenging theories of aging, to preserve hearing integrity, to fight against senescence of neural stem cells, or to explore brain fitness from gene expression to cognitive and social behavior? Here are the main issues that can be considered, stressing the complementarities of the models. The differentiation of aging physiological aspects from those induced by age-related pathologies will also be specified. By emphasizing recent ability of technologies to promote new aging insights, we discuss towards a better understanding of mechanisms governing aging.
authors.affiliation: Université Montpellier 1, CNRS UMR 5237, équipe biotechnologies du vieillissement, 1919 route de Mende, 34293 Montpellier Cedex 5, France. simon.galas@univ-montp1.fr
authors.forename: Simon
authors.initials: S
authors.lastname: Galas
authors.forename: Marie-Thérèse
authors.initials: MT
authors.lastname: Château
authors.forename: Pascal
authors.initials: P
authors.lastname: Pomiès
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Julien
authors.initials: J
authors.lastname: Menardo
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Puel
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Hugnot
authors.forename: Jean-Michel
authors.initials: JM
authors.lastname: Verdier
authors.forename: Gina
authors.initials: G
authors.lastname: Devau
mesh_terms: D000375:Aging / Q000502:physiology*; D000544:Alzheimer Disease / Q000235:genetics / Q000503:physiopathology; D000818:Animals; D001921:Brain / Q000254:growth & development / Q000503:physiopathology; D017173:Caenorhabditis elegans / Q000166:cytology / Q000502:physiology; D016922:Cellular Senescence; D016565:Cheirogaleidae; D003051:Cochlea / Q000254:growth & development / Q000503:physiopathology; D004195:Disease Models, Animal; D020869:Gene Expression Profiling; D020022:Genetic Predisposition to Disease; D006801:Humans; D008136:Longevity / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D008818:Mice, Neurologic Mutants; D008954:Models, Biological; D058953:Neural Stem Cells / Q000502:physiology; D019636:Neurodegenerative Diseases / Q000503:physiopathology; D011304:Presbycusis / Q000235:genetics / Q000503:physiopathology