title: Systemic mastocytosis with skeletal involvement: a case report and review of the literature.
abstract: Systemic Mastocytosis (SM) comprises a heterogeneous group of disorders of mast cell proliferation. Infiltration, including skin and bone, of multiple mast cells may occur as cutaneous and systemic variants. A rare form of osteoporosis has been also described as expression of the skeletal involvement. Here, we describe a case of a 57-years-old woman with SM and, according to the clinical diagnosis, evaluate the possible mechanism underlying osteoporosis. Moreover, a review of the literature, particularly regarding the use of bisphosphonates in this rare disease is also presented.
authors.affiliation: Section of Rheumatology Department of Internal Medicine, Nuovo Ospedale di S. Giovanni di Dio, Azienda Sanitaria di Firenze, Italy.
authors.forename: Maurizio
authors.initials: M
authors.lastname: Benucci
authors.forename: Catia
authors.initials: C
authors.lastname: Bettazzi
authors.forename: Stefania
authors.initials: S
authors.lastname: Bracci
authors.forename: Plinio
authors.initials: P
authors.lastname: Fabiani
authors.forename: Laura
authors.initials: L
authors.lastname: Monsacchi
authors.forename: Carlo
authors.initials: C
authors.lastname: Cappelletti
authors.forename: Mariangela
authors.initials: M
authors.lastname: Manfredi
authors.forename: Stefania
authors.initials: S
authors.lastname: Ciolli