title: Hydrogen peroxide-inducible clone 5 (Hic-5) as a potential therapeutic target for vascular and other disorders.
abstract: Hydrogen peroxide-inducible clone-5 (Hic-5) is a focal adhesion scaffold protein primarily expressed in vascular and visceral smooth muscle cells. We recently generated mice lacking Hic-5, which grew with no apparent abnormality (Kim-Kaneyama J, et al. J Mol Cell Cardiol. 2011;50(1):77-86). However, we discovered that recovery of arterial media following vascular injury is delayed significantly in Hic-5 knockout mice consequent to enhanced apoptosis of cultured vascular smooth muscle cells after mechanical stress; thus, Hic-5 is regarded as a novel factor in vascular remodeling. The Hic-5 gene is also induced by transforming growth factor-β, a well-known accelerator in fibrosis. Hic-5 involvement in various fibrotic disorders, e.g., scar formation, keloid formation and glomerulosclerosis, has been proposed. siRNA silencing of Hic-5 in a breast cancer cell line reduces its invasiveness; moreover, Hic-5 serves as a steroid hormone co-activator and likely participates in endometriosis and prostate cancer. Thus, functional characterization of Hic-5 in various pathophysiological conditions may afford novel mechanistic insights into a wide variety of diseases.
authors.affiliation: Department of Biochemistry, Showa University School of Medicine, Shinagawa-ku, Tokyo, Japan. shuri@pharm.showa-u.ac.jp
authors.forename: Joo-ri
authors.initials: JR
authors.lastname: Kim-Kaneyama
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Lei
authors.forename: Shigeko
authors.initials: S
authors.lastname: Arita
authors.forename: Aya
authors.initials: A
authors.lastname: Miyauchi
authors.forename: Takuro
authors.initials: T
authors.lastname: Miyazaki
authors.forename: Akira
authors.initials: A
authors.lastname: Miyazaki
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003598:Cytoskeletal Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D060588:LIM Domain Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D051379:Mice; D009369:Neoplasms / Q000517:prevention & control*; D014652:Vascular Diseases / Q000517:prevention & control*
chemical_list: D000970:Antineoplastic Agents; D003598:Cytoskeletal Proteins; D004268:DNA-Binding Proteins; D047908:Intracellular Signaling Peptides and Proteins; D060588:LIM Domain Proteins; C490351:TGFB1I1 protein, human; C090090:Tgfb1i1 protein, mouse