title: Treatment of rapid weight loss in a donor with hepatic steatosis in living donor liver transplantation: a case report.
abstract: The use of steatotic livers for transplantation is often associated with increased primary non-function. To reduce the risk of liver injury, steatosis of the donor liver in living donor liver transplantation (LDLT) was treated with restricted diet and exercise. A 21-year-old male donor, 167cm in height and 87kg in body weight, initially received a 1800kcal/day diet for 9 days which was then gradually reduced using a 1600kcal/day diet for 43 days, followed by a 1500kcal/day diet for one day and was finally maintained on a 1400kcal/day diet for 52 days. Daily exercise consumed 500kcal/day. The non-protein respiratory quotient (npRQ) gradually increased while the non-esterified fatty acids (NEFA) decreased during the course of the 105-day treatment. Consequently, the initial 80% steatosis was reduced to 10% and was accompanied by 13% weight loss for 81 days. The npRQ values and NEFA concentrations in the later period of dietary and exercise treatment were higher and lower, respectively, than in the early treatment period, indicating compensation through long-term treatment. Therefore, energy metabolism and NEFA levels represent important biomarkers for short-term intensive treatment by restricted diet and exercise in donors with hepatic steatosis.
authors.affiliation: Department of Clinical Nutrition, University of Tokushina Graduate School, Tokushima, Japan.
authors.forename: Hisami
authors.initials: H
authors.lastname: Yamanaka-Okumura
authors.forename: Eri
authors.initials: E
authors.lastname: Urano
authors.forename: Akihiko
authors.initials: A
authors.lastname: Kawaura
authors.forename: Satoru
authors.initials: S
authors.lastname: Imura
authors.forename: Tohru
authors.initials: T
authors.lastname: Utsunomiya
authors.forename: Mitsuo
authors.initials: M
authors.lastname: Shimada
authors.forename: Eiji
authors.initials: E
authors.lastname: Takeda
mesh_terms: D015415:Biomarkers / Q000097:blood; D031204:Caloric Restriction; D046148:Donor Selection; D004734:Energy Metabolism; D015444:Exercise; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005234:Fatty Liver / Q000097:blood / Q000175:diagnosis / Q000178:diet therapy*; D006498:Hepatectomy; D006801:Humans; D016031:Liver Transplantation / Q000379:methods*; D019520:Living Donors; D008297:Male; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome; D015431:Weight Loss; D055815:Young Adult
chemical_list: D015415:Biomarkers; D005230:Fatty Acids, Nonesterified