title: Antiviral furanosesquiterpenes from Commiphora erythraea.
abstract: The crude methanolic extract obtained from C. erythraea resin was chromatographed on silica gel with solvent of increasing polarity. The extract and fractions were evaluated for cytotoxicity and antiviral activity [parainfluenza type 3 virus (PIV3)] by plaque forming units (PFU) reduction assay using HEp-2 cells (human larynx epidermoid carcinoma cell line). From the active fraction, five compounds were isolated and tested. Only two of these showed anti-PIV3 activity with a selectivity index (SI) of 66.6 and 17.5, respectively. Both the compounds are furanosesquiterpenoids.
authors.affiliation: Dipartimento di Medicina Sperimentale e Scienze Biochimiche- Sez. Microbiologia, Università degli Studi di Perugia, via del Giochetto, 06122 Perugia, Italy.
authors.forename: Elio
authors.initials: E
authors.lastname: Cenci
authors.forename: Federica
authors.initials: F
authors.lastname: Messina
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Rossi
authors.forename: Francesco
authors.initials: F
authors.lastname: Epifano
authors.forename: Maria Carla
authors.initials: MC
authors.lastname: Marcotullio
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D029744:Commiphora / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D010224:Parainfluenza Virus 3, Human / Q000187:drug effects*; D012717:Sesquiterpenes / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D012717:Sesquiterpenes