title: Added value of use of a purified protein derivative-based enzyme-linked immunosorbent spot assay for patients with Mycobacterium bovis BCG infection after intravesical BCG instillations.
abstract: In this case series, we describe four cases in which the use of gamma interferon release assays with purified protein derivative (PPD) as a stimulating antigen was able to demonstrate PPD-specific immune activation. This may help to improve the adequate diagnosis of (systemic) Mycobacterium bovis BCG infections after intravesical BCG instillations for bladder carcinoma.
authors.affiliation: Diakonessenhuis Utrecht, Medical Microbiology and Immunology, Utrecht, The Netherlands. K.A.Heemstra@umcutrecht.nl
authors.forename: Karen A
authors.initials: KA
authors.lastname: Heemstra
authors.forename: Ailko W J
authors.initials: AW
authors.lastname: Bossink
authors.forename: Roan
authors.initials: R
authors.lastname: Spermon
authors.forename: John J M
authors.initials: JJ
authors.lastname: Bouwman
authors.forename: Robert
authors.initials: R
authors.lastname: van der Kieft
authors.forename: Steven F T
authors.initials: SF
authors.lastname: Thijsen
mesh_terms: D000283:Administration, Intravesical; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D059425:Interferon-gamma Release Tests / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009163:Mycobacterium bovis / Q000276:immunology*; D014373:Tuberculin / Q000276:immunology; D014376:Tuberculosis / Q000175:diagnosis* / Q000382:microbiology; D001749:Urinary Bladder Neoplasms / Q000628:therapy*
chemical_list: D014373:Tuberculin