title: Properties of nanoparticles prepared from NdFeB-based compound for magnetic hyperthermia application.
abstract: Nanoparticles were prepared from a NdFeB-based alloy using the hydrogen decrepitation process together with high-energy ball milling and tested as heating agent for magnetic hyperthermia. In the milling time range evaluated (up to 10 h), the magnetic moment per mass at H = 1.59 MA m(-1) is superior than 70 A m(2) kg(-1); however, the intrinsic coercivity might be inferior than 20 kA m(-1). The material presents both ferromagnetic and superparamagnetic particles constituted by a mixture of phases due to the incomplete disproportionation reaction of Nd(2)Fe(14)BH(x) during milling. Solutions prepared with deionized water and magnetic particles exposed to an AC magnetic field (H(max) ~ 3.7 kA m(-1) and f = 228 kHz) exhibited 26 K ≤ ΔT(max) ≤ 44 K with a maximum estimated specific absorption rate (SAR) of 225 W kg(-1). For the pure magnetic material milled for the longest period of time (10 h), the SAR was estimated as ~2500 W kg(-1). In vitro tests indicated that the powders have acceptable cytotoxicity over a wide range of concentration (0.1-100 µg ml(-1)) due to the coating applied during milling.
authors.affiliation: Center for Process and Product Technology, Institute of Technological Research, São Paulo, SP 05508-901, Brazil. eaperigo@ieee.org
authors.forename: E A
authors.initials: EA
authors.lastname: Périgo
authors.forename: S C
authors.initials: SC
authors.lastname: Silva
authors.forename: E M B
authors.initials: EM
authors.lastname: de Sousa
authors.forename: A A
authors.initials: AA
authors.lastname: Freitas
authors.forename: R
authors.initials: R
authors.lastname: Cohen
authors.forename: L C C M
authors.initials: LC
authors.lastname: Nagamine
authors.forename: H
authors.initials: H
authors.lastname: Takiishi
authors.forename: F J G
authors.initials: FJ
authors.lastname: Landgraf
mesh_terms: D000818:Animals; D001896:Boron Compounds / Q000737:chemistry; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D006979:Hyperthermia, Induced / Q000295:instrumentation; D058085:Iron Compounds / Q000737:chemistry; D060526:Magnetic Fields; D059346:Magnets / Q000737:chemistry* / Q000633:toxicity; D051379:Mice; D053758:Nanoparticles / Q000737:chemistry* / Q000633:toxicity; D036103:Nanotechnology / Q000379:methods*; D009354:Neodymium / Q000737:chemistry* / Q000633:toxicity; D014867:Water / Q000737:chemistry
chemical_list: D001896:Boron Compounds; D058085:Iron Compounds; D014867:Water; D009354:Neodymium