title: Cardiovascular baroreceptor activity and selective inhibition of monoamine oxidase.
abstract: Cardiovascular baroreceptor responsiveness of conscious rats treated with selective inhibitors of monoamine oxidase (MAO) types A and B was determined by measurement of blood pressure (BP) and heart rate (HR) responses to intravenous injection of phenylephrine and sodium nitroprusside. Treatment with selegiline (1 or 5 mg/kg p.o. daily for 7 days) did not significantly modify resting levels of BP and HR, lower or upper HR plateau levels, or HR/BP gain. Treatment with clorgyline (2 mg/kg p.o. daily for 7 days) increased HR/BP gain but also did not modify resting BP or HR, or lower and upper plateau levels of HR. The results are compatible with an effect of MAO-A inhibition to modify monoamine levels in medullary areas participating in CNS control of blood pressure.
authors.affiliation: Dept of Molecular Pharmacology, Rappaport Faculty of Medicine, Technion, POB 9649, Haifa 31096, Israel.
authors.forename: Orit
authors.initials: O
authors.lastname: Bar-Am
authors.forename: Aviva
authors.initials: A
authors.lastname: Gross
authors.forename: Rachel
authors.initials: R
authors.lastname: Friedman
authors.forename: John P M
authors.initials: JP
authors.lastname: Finberg
mesh_terms: D000818:Animals; D017704:Baroreflex / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D003010:Clorgyline / Q000009:adverse effects / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate / Q000187:drug effects; D006973:Hypertension / Q000139:chemically induced; D007022:Hypotension / Q000139:chemically induced; D007275:Injections, Intravenous; D007527:Isoenzymes / Q000037:antagonists & inhibitors / Q000378:metabolism; D008297:Male; D008995:Monoamine Oxidase / Q000737:chemistry / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D011311:Pressoreceptors / Q000737:chemistry / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012642:Selegiline / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology; D014662:Vasoconstrictor Agents / Q000008:administration & dosage / Q000494:pharmacology; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D007527:Isoenzymes; D008996:Monoamine Oxidase Inhibitors; D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents; D012642:Selegiline; D008995:Monoamine Oxidase; D003010:Clorgyline