title: Study of surface activity of piroxicam at the interface of palm oil esters and various aqueous phases.
abstract: The surface activity of some non-steroidal anti-inflammatory agents like ibuprofen was investigated extensively. This fact has attracted the researchers to extend this behavior to other agents like piroxicam. Piroxicam molecules are expected to orient at the interface of oil and aqueous phase. The aim of this study was, firstly, to assess the surface and interfacial tension behaviour of newly synthesised palm oil esters and various pH phosphate buffers. Furthermore, the surface and interfacial tension activity of piroxicam was studied. All the measurements of surface and interfacial tension were made using the tensiometer. The study revealed that piroxicam has no effect on surface tension values of all pH phosphate buffers and palm oil esters. Similarly, various concentrations of piroxicam did not affect the interfacial tensions between the oil phase and the buffer phases. Accordingly, the interfacial tension values of all mixtures of oil and phosphate buffers were considerably high which indicates the immiscibility. It could be concluded that piroxicam has no surface activity. Additionally, there is no surface pressure activity of piroxicam at the interface of plam oil esters and phosphate buffers in the presence of Tweens and Spans.
authors.affiliation: School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden, Pulau Penang, Malaysia. muthana_albuldawy@yahoo.com
authors.forename: Muthanna Fawzy
authors.initials: MF
authors.lastname: Abdulkarim
authors.forename: Ghassan Zuhair
authors.initials: GZ
authors.lastname: Abdullah
authors.forename: Mallikarjun
authors.initials: M
authors.lastname: Chitneni
authors.forename: Mun Fei
authors.initials: MF
authors.lastname: Yam
authors.forename: Elrashid Saleh
authors.initials: ES
authors.lastname: Mahdi
authors.forename: Ibrahim Muhammad
authors.initials: IM
authors.lastname: Salman
authors.forename: Omar Ziad
authors.initials: OZ
authors.lastname: Ameer
authors.forename: Munavvar Abdul
authors.initials: MA
authors.lastname: Sattar
authors.forename: Mahiran
authors.initials: M
authors.lastname: Basri
authors.forename: Azmin Mohd
authors.initials: AM
authors.lastname: Noor
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D000073878:Palm Oil; D010894:Piroxicam / Q000737:chemistry*; D010938:Plant Oils / Q000737:chemistry; D013500:Surface Tension
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010938:Plant Oils; D010894:Piroxicam; D000073878:Palm Oil