title: Solitary, multifocal and generalized myofibromas: clinicopathological and immunohistochemical features of 114 cases.
abstract: OBJECTIVE
  To report a large series of solitary and multiple myofibromas with systematic clinicopathological correlations.
  
  
  RESULTS
  We report on 114 patients with myofibromas, 97 of which were solitary and 17 multifocal. The age at presentation ranged from newborn to 70 years. All multifocal myofibromas and 91% of solitary myofibromas occurred in children. The head and neck region was the most common site (n = 43), followed by the trunk (n = 24), lower limbs (n = 14), upper limbs (n = 11), and viscera (n = 4). Solitary and multifocal myofibromas stained positively for smooth muscle actin (SMA) in 95% and 92% of cases, muscle-specific actin (MSA) in 75% and 50% of cases, and desmin in 10% and 14% of cases, respectively. Regressive features were seen in 34 solitary myofibromas and in nine multifocal myofibromas. Most patients were treated with complete excision (n = 79) or partial excision (n = 12). There were no recurrences after treatment.
  
  
  CONCLUSIONS
  Solitary and multiple myofibromas are benign tumours that predominantly occur in infancy and childhood. Myofibromas occur especially in the head and neck region, and are characterized by SMA and, to a lesser extent, MSA expression. The clinical course is self-limiting, and local excision appears to be sufficient.
authors.affiliation: Department of Pathology, Josephine Nefkens Institute, Erasmus MC, Rotterdam, The Netherlands.
authors.forename: Lindsey
authors.initials: L
authors.lastname: Oudijk
authors.forename: Michael A
authors.initials: MA
authors.lastname: den Bakker
authors.forename: Wim C J
authors.initials: WC
authors.lastname: Hop
authors.forename: Marta
authors.initials: M
authors.lastname: Cohen
authors.forename: Adrian K
authors.initials: AK
authors.lastname: Charles
authors.forename: Rita
authors.initials: R
authors.lastname: Alaggio
authors.forename: Cheryl M
authors.initials: CM
authors.lastname: Coffin
authors.forename: Ronald R
authors.initials: RR
authors.lastname: de Krijger
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D005260:Female; D006258:Head and Neck Neoplasms / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D047708:Myofibroma / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor