title: Diarylprolinol in an asymmetric aldol reaction of an α-alkyl-α-oxo aldehyde as an electrophile.
abstract: The direct aldol reaction of an α-alkyl-α-oxo aldehyde was catalyzed by trifluoromethyl-substituted diarylprolinol 1 to afford a γ-oxo-β-hydroxy-α-substituted aldehyde in good yield with excellent anti-selectivity and excellent enantioselectivity.
authors.affiliation: Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo 162-8601, Japan. hayashi@ci.kagu.tus.ac.jp
authors.forename: Yujiro
authors.initials: Y
authors.lastname: Hayashi
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Yasui
authors.forename: Masahiro
authors.initials: M
authors.lastname: Kojima
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Kawamura
authors.forename: Hayato
authors.initials: H
authors.lastname: Ishikawa