title: Glutathione S-transferase polymorphisms and bone tumor risk in China.
abstract: OBJECTIVE
  We aimed to study the potential role of GSTM1 and GSTT1 in the risk of osteosarcoma in Chinese population.
  
  
  METHODS
  We collected 110 osteosarcomas by pathologic examination and 226 controls from the First Affiliated Hospital of Harbin Medical University during December 2008 to December 2010. Genotyping was based upon duplex polymerase-chain-reaction with the PCR-CTPP method.
  
  
  RESULTS
  Individuals carrying null GSTM1 and GSTT1 had 1.50 and 2.07 fold risks of osteosarcoma when compared with non-null genotypes, respectively. The increased risk associated with the GSTT1 polymorphism seemed more evident among males (Null GSTT1 genotype vs. non-null genotype, adjusted OR= 2.43, 95% CI: 1.29-3.30) than females (adjusted OR =1.66, 95% CI: 1.02-2.78). The increased risk was also more evident among individuals aged 15 years or less (adjusted OR for null GSTT1 genotype vs. non-null genotype = 2.24, 95% CI: 1.20-3.24) than those aged more than 15 years (adjusted OR = 1.82, 95% CI: 1.07-2.95).
  
  
  CONCLUSIONS
  Our study of the association between polymorphisms in GSTM1 and GSTTI and the risk of osteosarcoma in a Chinese population provided evidence that null GSTTI might be a useful marker of susceptibility to osteosarcoma development, especially for male sand young age individuals.
authors.affiliation: The First Affiliated Hospital of Harbin Medical University, Harbin, China. shellylu2001@126.com
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Lu
authors.forename: Wei-Liang
authors.initials: WL
authors.lastname: Yang
authors.forename: Zhen-Hai
authors.initials: ZH
authors.lastname: Wan
authors.forename: Jia
authors.initials: J
authors.lastname: Li
authors.forename: Zheng-Gang
authors.initials: ZG
authors.lastname: Bi
mesh_terms: D000293:Adolescent; D044466:Asian People / Q000235:genetics*; D001859:Bone Neoplasms / Q000235:genetics* / Q000401:mortality; D016022:Case-Control Studies; D004247:DNA / Q000235:genetics; D004198:Disease Susceptibility; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D008297:Male; D012516:Osteosarcoma / Q000235:genetics* / Q000401:mortality; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D012307:Risk Factors; D015996:Survival Rate
chemical_list: D004247:DNA; D005982:Glutathione Transferase; C413545:glutathione S-transferase T1