title: Elemental concentrations in scalp hair, nutritional status and health-related quality of life in hemodialysis patients.
abstract: Elemental concentrations in hair from hemodialysis (HD) patients have not been well investigated. We examined the relationships between the elemental concentrations in scalp hair and health-related quality of life (HRQOL) and nutritional status in HD patients. Twenty six elemental concentrations were measured in scalp hair samples from 60 male HD patients using inductively-coupled plasma mass spectrometry. To evaluate HRQOL, the Short Form 36 item health survey (SF36) was used. As indices of nutritional status, body mass index, serum parameters, and geriatric nutritional risk index (GNRI) were used. Phosphorus correlated positively with serum creatinine, blood urea nitrogen (BUN), GNRI and the physical domains of the SF36. Zinc correlated positively with serum creatinine, BUN and the physical domains of the SF36. Mercury and arsenic correlated positively with BUN. Cadmium correlated negatively with serum albumin, BUN and GNRI. Copper correlated positively with the physical domains of the SF36. Iodine correlated negatively with the physical domains of the SF36. Selenium correlated negatively with the mental domains of the SF36. In conclusion, phosphorus and zinc concentrations in scalp hair can be additional biomarkers of HRQOL and/or nutritional status in HD patients. Cadmium accumulation correlated with malnutrition. Iodine and selenium accumulation may adversely affect HRQOL. Further investigation is necessary to determine precisely how these elements affect these measures.
authors.affiliation: Metabolism, Endocrinology, Molecular Medicine and Nephrology, Osaka City University Graduate School of Medicine, Osaka, Japan.
authors.forename: Akinobu
authors.initials: A
authors.lastname: Ochi
authors.forename: Eiji
authors.initials: E
authors.lastname: Ishimura
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Tsujimoto
authors.forename: Ryusuke
authors.initials: R
authors.lastname: Kakiya
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Tabata
authors.forename: Katsuhito
authors.initials: K
authors.lastname: Mori
authors.forename: Hideki
authors.initials: H
authors.lastname: Tahara
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Shoji
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Yasuda
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Nishizawa
authors.forename: Masaaki
authors.initials: M
authors.lastname: Inaba
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000032:analysis; D001823:Body Composition; D015992:Body Mass Index; D006197:Hair / Q000737:chemistry*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy*; D008297:Male; D013058:Mass Spectrometry; D008875:Middle Aged; D009752:Nutritional Status; D011788:Quality of Life; D006435:Renal Dialysis / Q000523:psychology*; D012535:Scalp; D011795:Surveys and Questionnaires
chemical_list: D015415:Biomarkers