title: Age-specific dynamics of human thymus immune cell differentiation.
abstract: The expression of markers of undifferentiated CD5+ cells, B cells, T-killer/suppressors, and T-helpers was verified by immunohistochemical methods in the thymuses of elderly, senile, and long-lived humans. The counts of CD5+ cells in the thymus progressively decreased with age. Positive correlations between the counts of CD5+ cells and differentiated T cells were detected. The capacity of CD5+ thymocytes to differentiate into T-killer/suppressors decreased with age.
authors.affiliation: St. Petersburg Institute of Bioregulation and Gerontology, North-Western Division of the Russian Academy of Medical Sciences, Russia.
authors.forename: V Kh
authors.initials: VKh
authors.lastname: Khavinson
authors.forename: N S
authors.initials: NS
authors.lastname: Linkova
authors.forename: V O
authors.initials: VO
authors.lastname: Polyakova
authors.forename: A V
authors.initials: AV
authors.lastname: Dudnov
authors.forename: I M
authors.initials: IM
authors.lastname: Kvetnoy
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000378:metabolism; D002452:Cell Count; D002454:Cell Differentiation; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism / Q000502:physiology; D008875:Middle Aged; D060168:Thymocytes / Q000378:metabolism / Q000502:physiology*; D013950:Thymus Gland / Q000166:cytology*
chemical_list: D015703:Antigens, CD