title: Sirenomelia apus after trimethoprim exposure: first-trimester ultrasound diagnosis-a case report.
abstract: We report the early prenatal ultrasound diagnosis of sirenomelia apus at 12+4 weeks in a patient with trimethoprim exposure in the vulnerable period. First-trimester scan revealed a malformed fetus with one femur, one small tibia, no feet, intraabdominal unilocular cystic structure, and two-vessel umbilical cord with allantoic cyst. Ultrasound visualization with two/three/four-dimensions was helpful in the process of parental counseling.
authors.affiliation: Slovak Medical University, Bratislava, III. Department of Gynaecology and Obstetrics, 1st Private Hospital Košice-Šaca Inc., Košice-Šaca, Slovak Republic.
authors.forename: Erik
authors.initials: E
authors.lastname: Dosedla
authors.forename: Michaela
authors.initials: M
authors.lastname: Kalafusová
authors.forename: Pavel
authors.initials: P
authors.lastname: Calda
mesh_terms: D000025:Abortion, Eugenic; D000328:Adult; D000892:Anti-Infective Agents, Urinary / Q000009:adverse effects; D004480:Ectromelia / Q000139:chemically induced* / Q000000981:diagnostic imaging*; D005260:Female; D005315:Fetal Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging*; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D038061:Lower Extremity Deformities, Congenital / Q000139:chemically induced* / Q000000981:diagnostic imaging*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011297:Prenatal Exposure Delayed Effects / Q000000981:diagnostic imaging*; D014295:Trimethoprim / Q000009:adverse effects*; D016216:Ultrasonography, Prenatal / Q000379:methods*
chemical_list: D000892:Anti-Infective Agents, Urinary; D014295:Trimethoprim