title: Investigation on genetic heterogeneity of α-subunit of the epithelial sodium channel in rat renal cortex.
abstract: Genotypic variability of αENaC mRNA in adult rat kidney caused by deletion at the 3'-end of α-subunit DNA was studied by real-time PCR using specific probes with a fluorescent dye (TaqMan). It was found that mRNA deletion forms (a and b), products of alternative splicing of aENaC gene, are absent in the cortex of adult rat kidney.
authors.affiliation: Institute of Cytology and Genetics, Siberian Division of Russian Academy of Sciences, Novosibirsk, Russia. ninlo@bionet.nsc.ru
authors.forename: N S
authors.initials: NS
authors.lastname: Logvinenko
authors.forename: Y E
authors.initials: YE
authors.lastname: Herbeck
authors.forename: L N
authors.initials: LN
authors.lastname: Ivanova
mesh_terms: D017398:Alternative Splicing / Q000235:genetics; D000818:Animals; D053503:Epithelial Sodium Channels / Q000235:genetics*; D018740:Genetic Heterogeneity; D007672:Kidney Cortex / Q000378:metabolism*; D051381:Rats; D060888:Real-Time Polymerase Chain Reaction; D012964:Sodium / Q000378:metabolism
chemical_list: D053503:Epithelial Sodium Channels; D012964:Sodium