title: Synthesis and anti-HIV activity of novel 2,4-disubstituted-7-methyl-1,1,3-trioxo-2H,4H-pyrazolo[4,5-e][1,2,4]thiadiazine derivatives.
abstract: A series of novel 2,4-disubstituted-7-methyl-1,1,3-trioxo-2H,4H-pyrazolo[4,5-e][1,2,4]thiadiazines (PTDs) was prepared starting from a ring of pyrazolo[4,5-e][1,2,4]thiadiazine nuclei with two different alkyl halides obtained by a facile one-pot reaction. The structures of all synthesized compounds were confirmed by1H- and13C-NMR, infrared spectra (IR), and mass spectra (MS) spectroscopic analysis. Anti-HIV activity was evaluated and none of the compounds were found to inhibit HIV replication in human T-lymphocyte (MT-4) cell culture.
authors.affiliation: Institute of Medicinal Chemistry, School of Pharmaceutical Sciences, Shandong University, Ji'nan, China.
authors.forename: P
authors.initials: P
authors.lastname: Zhan
authors.forename: R Z
authors.initials: RZ
authors.lastname: Yan
authors.forename: X Y
authors.initials: XY
authors.lastname: Liu
authors.forename: C
authors.initials: C
authors.lastname: Pannecouque
authors.forename: M
authors.initials: M
authors.lastname: Witvrouw
authors.forename: E
authors.initials: E
authors.lastname: De Clercq
authors.forename: M T
authors.initials: MT
authors.lastname: Molina
authors.forename: S
authors.initials: S
authors.lastname: Vega