title: Usefulness of serum lipid peroxide as a diagnostic test for hypoxic ischemic encephalopathy in the full-term neonate.
abstract: OBJECTIVE
  To evaluate the usefulness of serum lipid peroxide (LPO) for hypoxic ischemic encephalopathy (HIE) in full-term neonates.
  
  
  METHODS
  Diagnostic test evaluation forming three groups: (1) healthy full-term neonates (n=59), (2) at-risk full-term neonates without HIE (n=57) and (3) at-risk full-term neonates with HIE (n=57). HIE diagnosis was made using the Finer clinical classification at 48 h after birth. Serum LPO was taken at 4 h after birth and determined by spectrophotometry.
  
  
  RESULTS
  One hundred seventy-three full-term neonates were studied. Fifty-one of the at-risk full-term neonates with HIE (51/57) had high serum LPO and two of the at-risk full-term neonates without HIE (2/57) (P<0.001). Serum LPO level had 89% sensitivity, 96% specificity, 96% positive predictive value, 90% negative predictive value, 24 positive probability ratio, 0.11 negative probability ratio and 92% diagnostic usefulness.
  
  
  CONCLUSIONS
  Serum LPO level could be a useful test for early diagnosis of HIE in full-term neonates.
authors.affiliation: UMAE Hospital de Pediatría CMNO, Instituto Mexicano del Seguro Social, Hospital Materno Infantil Esperanza López Mateos, Secretaria de Salud Jalisco, Guadalajara, Mexico. jcbarrer@hotmail.com
authors.forename: J C
authors.initials: JC
authors.lastname: Barrera-de León
authors.forename: R
authors.initials: R
authors.lastname: Cervantes-Munguía
authors.forename: C
authors.initials: C
authors.lastname: Vásquez
authors.forename: M A
authors.initials: MA
authors.lastname: Higareda-Almaraz
authors.forename: A
authors.initials: A
authors.lastname: Bravo-Cuellar
authors.forename: L
authors.initials: L
authors.lastname: González-López
mesh_terms: D001034:Apgar Score; D001238:Asphyxia Neonatorum / Q000097:blood* / Q000175:diagnosis*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000097:blood* / Q000175:diagnosis*; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal; D008054:Lipid Peroxides / Q000097:blood*; D008297:Male; D011237:Predictive Value of Tests; D012307:Risk Factors; D013053:Spectrophotometry
chemical_list: D008054:Lipid Peroxides