title: Serum levels of selected chemokines in systemic lupus erythematosus patients.
abstract: Chemokines promote leukocyte traffic into the site of inflammation. Serum levels of monocyte chemotactic protein 1 (MCP-1), stromal cell-derived factor-1 (SDF-1), interferon-gamma-inducible protein 10 (IP-10), and interleukin-8 (IL-8) were evaluated in 48 treated women with systemic lupus erythematosus (SLE) and mild-to-moderate disease severity. The results were compared between the whole SLE group and the control (29 women). The relationships between chemokines, their concentrations, and peripheral blood leukocyte count and between the chemokines and individual leukocyte populations (polymorphonuclear leukocytes-PMNs, lymphocytes-Ls, monocytes-Ms, eosinophils) counts were determined. The relationships between the analyzed chemokines were also determined in the control. SLE subjects had significantly higher MCP-1, SDF-1, IP-10, and lower IL-8 concentrations compared to the control. Moderate, positive correlations between MCP-1/SDF-1, SDF-1/IP-10 and a negative correlation between MCP-1/IL8 were observed in the patient group. Moderate, negative correlations were found between SDF-1/total leukocyte count, SDF-1/absolute number of PMNs as well as between IP-10/total leukocyte count, IP-10/absolute PMNs, Ls, and Ms counts in peripheral blood of SLE group. We suggest that the obtained results and correlations observed between the examined parameters might be used to monitor SLE course and progression. However, further randomized clinical studies should be carried out on in untreated and treated patients with SLE.
authors.affiliation: Student Scientific Section at the Department of Internal, Autoimmune, and Metabolic Diseases, Medical University of Silesia, ul. Medyków 14, 40-752 Katowice, Poland.
authors.forename: Eugeniusz
authors.initials: E
authors.lastname: Hrycek
authors.forename: Andrzej
authors.initials: A
authors.lastname: Franek
authors.forename: Edward
authors.initials: E
authors.lastname: Błaszczak
authors.forename: Justyna
authors.initials: J
authors.lastname: Dworak
authors.forename: Antoni
authors.initials: A
authors.lastname: Hrycek
mesh_terms: D000328:Adult; D000368:Aged; D018932:Chemokine CCL2 / Q000097:blood; D054357:Chemokine CXCL10 / Q000097:blood; D054377:Chemokine CXCL12 / Q000097:blood; D018925:Chemokines / Q000097:blood*; D005260:Female; D006801:Humans; D016209:Interleukin-8 / Q000097:blood; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: C114753:CXCL10 protein, human; C515255:CXCL12 protein, human; D018932:Chemokine CCL2; D054357:Chemokine CXCL10; D054377:Chemokine CXCL12; D018925:Chemokines; D016209:Interleukin-8