title: The pathogenesis of measles.
abstract: Measles is an important cause of childhood morbidity and mortality in developing countries. Measles virus (MV) is transmitted via the respiratory route and causes systemic disease. Over the last decade, identification of new cellular receptors and studies in animal models have challenged the historic concepts of measles pathogenesis. It is thought that MV enters the host by infection of alveolar macrophages and/or dendritic cells in the airways, and is amplified in local lymphoid tissues. Viremia mediated by infected CD150+ lymphocytes results in systemic dissemination. Infection of lymphocytes and dendritic cells in the respiratory submucosa facilitates basolateral infection of epithelial cells via the newly identified receptor Nectin-4. Concomitant and extensive epithelial damage may contribute to efficient transmission to the next host.
authors.affiliation: Department of Virology, Erasmus MC, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
authors.forename: Rory D
authors.initials: RD
authors.lastname: de Vries
authors.forename: Annelies W
authors.initials: AW
authors.lastname: Mesman
authors.forename: Teunis B H
authors.initials: TB
authors.lastname: Geijtenbeek
authors.forename: W Paul
authors.initials: WP
authors.lastname: Duprex
authors.forename: Rik L
authors.initials: RL
authors.lastname: de Swart
mesh_terms: D000818:Animals; D003713:Dendritic Cells / Q000821:virology; D004195:Disease Models, Animal; D004847:Epithelial Cells / Q000821:virology; D006801:Humans; D008198:Lymph Nodes / Q000821:virology; D008214:Lymphocytes / Q000821:virology; D008264:Macrophages / Q000821:virology; D008457:Measles / Q000473:pathology* / Q000821:virology*; D008459:Measles virus / Q000472:pathogenicity*; D011991:Receptors, Virus / Q000378:metabolism; D012137:Respiratory System / Q000821:virology; D014766:Viremia; D053586:Virus Internalization
chemical_list: D011991:Receptors, Virus