title: Micelles based on gold-glycopolymer complexes as new chemotherapy drug delivery agents.
abstract: Polymeric versions of deacetylated auranofin, a gold complex with a sugar ligand, were prepared by post-modifying RAFT glycopolymers. Micellisation of a block copolymer containing pendant Au(I) units produced nanoparticles with an increased anti-proliferative effect against OVCAR-3 human ovarian carcinoma cells.
authors.affiliation: Centre for Advanced Macromolecular Design, University of New South Wales, Sydney, Australia.
authors.forename: Samuel
authors.initials: S
authors.lastname: Pearson
authors.forename: Wei
authors.initials: W
authors.lastname: Scarano
authors.forename: Martina H
authors.initials: MH
authors.lastname: Stenzel
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry; D001310:Auranofin / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D016503:Drug Delivery Systems; D005260:Female; D006046:Gold / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008823:Micelles; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry; D010051:Ovarian Neoplasms / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents; D008823:Micelles; D009942:Organometallic Compounds; D001310:Auranofin; D006046:Gold