title: Myeloid-derived suppressor cells participate in preventing graft rejection.
abstract: Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of cells and have a tremendous potential to suppress immune responses. MDSCs accumulate during tumor progression, autoimmunity, chronic infection, transplantation, and other pathological conditions and can potently suppress T-cell function. Here, we discuss recent findings that describe the molecular mechanisms of MDSCs suppressing T-cell immune responses as well as recent observations that MDSCs may have roles in transplant tolerance.
authors.affiliation: Department of General Surgery, Huashan Hospital, Fudan University, Shanghai 200040, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Gu
authors.forename: Jianbin
authors.initials: J
authors.lastname: Xiang
authors.forename: Zongyou
authors.initials: Z
authors.lastname: Chen
mesh_terms: D019264:Adoptive Transfer; D000818:Animals; D017951:Antigen Presentation; D015415:Biomarkers / Q000032:analysis; D018414:CD8-Positive T-Lymphocytes / Q000166:cytology / Q000276:immunology; D006084:Graft Rejection / Q000276:immunology / Q000517:prevention & control*; D006098:Granulocytes / Q000166:cytology / Q000276:immunology / Q000637:transplantation; D006801:Humans; D007108:Immune Tolerance; D051379:Mice; D009000:Monocytes / Q000166:cytology / Q000276:immunology / Q000637:transplantation; D022423:Myeloid Cells / Q000166:cytology / Q000276:immunology* / Q000637:transplantation; D016377:Organ Transplantation; D050378:T-Lymphocytes, Regulatory / Q000166:cytology / Q000276:immunology; D014184:Transplantation, Homologous
chemical_list: D015415:Biomarkers