title: Report of the TFOS/ARVO Symposium on global treatments for dry eye disease: an unmet need.
abstract: In September 2010, a Symposium in Florence, Italy, was held to address the unmet need for global treatments for dry eye disease (DED). It was sponsored by The Tear Film & Ocular Surface Society (TFOS; www.TearFilm.org) and co-sponsored by the Association for Research in Vision & Ophthalmology (www.arvo.org). The Symposium objectives were two-fold: first, to discuss accepted and emerging clinical endpoints of DED with regulatory experts from around the world; and second, to consider how to improve clinical trials of treatments for DED. The Symposium focused on the personal and collective burden of DED, as well as the developmental and regulatory challenges associated with generating new DED therapeutics. This article provides a synopsis of many of the presentations, discussions and recommendations of this Symposium.
authors.affiliation: Schepens Eye Research Institute, Massachusetts Eye and Ear Infirmary and Department of Ophthalmology, Harvard Medical School, Boston, MA, USA. david.sullivan@schepens.harvard.edu
authors.forename: David A
authors.initials: DA
authors.lastname: Sullivan
authors.forename: Katherine M
authors.initials: KM
authors.lastname: Hammitt
authors.forename: Debra A
authors.initials: DA
authors.lastname: Schaumberg
authors.forename: Benjamin D
authors.initials: BD
authors.lastname: Sullivan
authors.forename: Carolyn G
authors.initials: CG
authors.lastname: Begley
authors.forename: Per
authors.initials: P
authors.lastname: Gjorstrup
authors.forename: Jean-Sébastien
authors.initials: JS
authors.lastname: Garrigue
authors.forename: Masatsugu
authors.initials: M
authors.lastname: Nakamura
authors.forename: Yann
authors.initials: Y
authors.lastname: Quentric
authors.forename: Stefano
authors.initials: S
authors.lastname: Barabino
authors.forename: Michelle
authors.initials: M
authors.lastname: Dalton
authors.forename: Gary D
authors.initials: GD
authors.lastname: Novack
mesh_terms: D015352:Dry Eye Syndromes / Q000628:therapy*; D014943:Global Health; D006301:Health Services Needs and Demand; D006801:Humans; D020380:Needs Assessment