title: I-region linked complementing loci in resistance to viral leukemogenesis in the mouse.
abstract: A-RadLV, a variant of the radiation leukemia virus, inoculated intrathymically into adult mice, causes a high frequency of leukemia in haplotypes b, f, k, d, p and j on the B10 background, whereas H-2s mice are resistant. Resistance is dominant and segregates with H-2s in the offspring of (b x s)b and (b x t2)b backcrosses. Analysis of recombinant strains revealed that resistance is associated with I-A and I-B. B10.A(5R), a recombinant of two sensitive haplotypes, was found to be resistant, suggesting intra-H-2-gene complementation. The resistance of such complementing loci was demonstrated also in the trans position by testing F1 mice bred from sensitive parents. These data are taken to suggest that I-region linked complementing loci, similar to classical Ir genes, may be involved in resistance to murine leukemia.
authors.affiliation: Department of Chemical Immunology, The Weizmann Institute of Science, Rehovot, Israel.
authors.forename: P
authors.initials: P
authors.lastname: Lonai
authors.forename: E
authors.initials: E
authors.lastname: Katz
authors.forename: N
authors.initials: N
authors.lastname: Haran-Ghera
mesh_terms: D000818:Animals; D003433:Crosses, Genetic; D060467:Disease Resistance / Q000235:genetics* / Q000276:immunology; D005802:Genes, MHC Class II / Q000276:immunology; D008040:Genetic Linkage; D006183:H-2 Antigens / Q000235:genetics* / Q000276:immunology; D015235:HLA-B Antigens / Q000235:genetics / Q000276:immunology; D006239:Haplotypes; D000949:Histocompatibility Antigens Class II / Q000235:genetics* / Q000276:immunology; D007938:Leukemia / Q000276:immunology / Q000821:virology*; D051379:Mice; D016721:Radiation Leukemia Virus / Q000276:immunology / Q000472:pathogenicity*
chemical_list: D006183:H-2 Antigens; D015235:HLA-B Antigens; D000949:Histocompatibility Antigens Class II