title: Enhanced delivery of chemotherapy to tumors using a multicomponent nanochain with radio-frequency-tunable drug release.
abstract: While nanoparticles maximize the amount of chemotherapeutic drug in tumors relative to normal tissues, nanoparticle-based drugs are not accessible to the majority of cancer cells because nanoparticles display patchy, near-perivascular accumulation in tumors. To overcome the limitations of current drugs in their molecular or nanoparticle form, we developed a nanoparticle based on multicomponent nanochains to deliver drug to the majority of cancer cells throughout a tumor while reducing off-target delivery. The nanoparticle is composed of three magnetic nanospheres and one doxorubicin-loaded liposome assembled in a 100 nm long chain. These nanoparticles display prolonged blood circulation and significant intratumoral deposition in tumor models in rodents. Furthermore, the magnetic particles of the chains serve as a mechanical transducer to transfer radio frequency energy to the drug-loaded liposome. The defects on the liposomal walls trigger the release of free drug capable of spreading throughout the entire tumor, which results in a widespread anticancer effect.
authors.affiliation: Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106, USA.
authors.forename: Pubudu M
authors.initials: PM
authors.lastname: Peiris
authors.forename: Lisa
authors.initials: L
authors.lastname: Bauer
authors.forename: Randall
authors.initials: R
authors.lastname: Toy
authors.forename: Emily
authors.initials: E
authors.lastname: Tran
authors.forename: Jenna
authors.initials: J
authors.lastname: Pansky
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Doolittle
authors.forename: Erik
authors.initials: E
authors.lastname: Schmidt
authors.forename: Elliott
authors.initials: E
authors.lastname: Hayden
authors.forename: Aaron
authors.initials: A
authors.lastname: Mayer
authors.forename: Ruth A
authors.initials: RA
authors.lastname: Keri
authors.forename: Mark A
authors.initials: MA
authors.lastname: Griswold
authors.forename: Efstathios
authors.initials: E
authors.lastname: Karathanasis
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D004195:Disease Models, Animal; D006801:Humans; D036103:Nanotechnology; D009369:Neoplasms / Q000188:drug therapy*; D011846:Radio Waves; D051381:Rats
chemical_list: D000970:Antineoplastic Agents