title: Recurrence of chronic active Epstein-Barr virus infection from donor cells after achieving complete response through allogeneic bone marrow transplantation.
abstract: We report the case of a 35-year-old woman with chronic active Epstein-Barr virus (EBV) infection (CAEBV). She underwent allogeneic bone marrow transplantation (BMT) from an unrelated male donor and achieved a complete response. However, her CAEBV relapsed one year after BMT. EBV-infected cells proliferated clonally and revealed a 46XY karyotype. In addition, the infecting EBV strain differed from that detected before BMT. These findings indicated that her disease had developed from donor cells. This is the first report of donor cell-derived CAEBV that recurred after transplantation, suggesting that host factors may be responsible for the development of this disease.
authors.affiliation: Department of Hematology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Japan. ara.hema@tmd.ac.jp
authors.forename: Ayako
authors.initials: A
authors.lastname: Arai
authors.forename: Ken-ichi
authors.initials: K
authors.lastname: Imadome
authors.forename: Ludan
authors.initials: L
authors.lastname: Wang
authors.forename: Nan
authors.initials: N
authors.lastname: Wu
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Kurosu
authors.forename: Atsushi
authors.initials: A
authors.lastname: Wake
authors.forename: Hisashi
authors.initials: H
authors.lastname: Yamamoto
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Ota
authors.forename: Masayoshi
authors.initials: M
authors.lastname: Harigai
authors.forename: Shigeyoshi
authors.initials: S
authors.lastname: Fujiwara
authors.forename: Osamu
authors.initials: O
authors.lastname: Miura
mesh_terms: D000328:Adult; D001483:Base Sequence; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D041321:Chromosomes, Human, X / Q000235:genetics; D041322:Chromosomes, Human, Y / Q000235:genetics; D002908:Chronic Disease; D004279:DNA, Viral / Q000235:genetics; D020031:Epstein-Barr Virus Infections / Q000209:etiology* / Q000235:genetics / Q000628:therapy* / Q000821:virology; D005260:Female; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008180:Lupus Erythematosus, Systemic / Q000150:complications; D008232:Lymphoproliferative Disorders / Q000209:etiology / Q000235:genetics / Q000628:therapy / Q000821:virology; D008297:Male; D012008:Recurrence; D013601:T-Lymphocytes / Q000821:virology; D014019:Tissue Donors; D014184:Transplantation, Homologous
chemical_list: D004279:DNA, Viral