title: Cluster analysis of rat olfactory bulb responses to diverse odorants.
abstract: In an effort to deepen our understanding of mammalian olfactory coding, we have used an objective method to analyze a large set of odorant-evoked activity maps collected systematically across the rat olfactory bulb to determine whether such an approach could identify specific glomerular regions that are activated by related odorants. To that end, we combined fuzzy c-means clustering methods with a novel validity approach based on cluster stability to evaluate the significance of the fuzzy partitions on a data set of glomerular layer responses to a large diverse group of odorants. Our results confirm the existence of glomerular response clusters to similar odorants. They further indicate a partial hierarchical chemotopic organization wherein larger glomerular regions can be subdivided into smaller areas that are rather specific in their responses to particular functional groups of odorants. These clusters bear many similarities to, as well as some differences from, response domains previously proposed for the glomerular layer of the bulb. These data also provide additional support for the concept of an identity code in the mammalian olfactory system.
authors.affiliation: Department of Chemistry and Physics, University of Brescia and CNR-IDASC, Via Valotti 9, 25133 Brescia, Italy.
authors.forename: Matteo
authors.initials: M
authors.lastname: Falasconi
authors.forename: Agustin
authors.initials: A
authors.lastname: Gutierrez-Galvez
authors.forename: Michael
authors.initials: M
authors.lastname: Leon
authors.forename: Brett A
authors.initials: BA
authors.lastname: Johnson
authors.forename: Santiago
authors.initials: S
authors.lastname: Marco
mesh_terms: D000818:Animals; D016000:Cluster Analysis; D003847:Deoxyglucose / Q000494:pharmacology; D009830:Olfactory Bulb / Q000187:drug effects / Q000502:physiology*; D025341:Principal Component Analysis; D051381:Rats; D012903:Smell
chemical_list: D003847:Deoxyglucose