title: [Sickle-cell retinopathy: Retrospective study of 730 patients followed in a referral center].
abstract: BACKGROUND
  Sickle-cell disease is the most common genetic disease in the world, frequently complicated by potentially blinding retinal complications. The prevalence of sickle-cell retinopathy in patients followed in a referral center is presented in this study.
  
  
  METHODS
  The prevalence of proliferative sickle-cell retinopathy by Goldberg classification was determined via a retrospective study of primarily adult SS and SC sickle-cell disease patients and AS sickle trait patients followed in a single referral center for a mean period of 13 years. All patients underwent slit lamp examination and complete fundus examination.
  
  
  RESULTS
  Seven hundred and thirty patients (mean age 32.5±10 years), consisting of 492 SS patients (67.4%), 229 SC patients (31.4%) and nine AS patients (1.2%), were included in the study. 54.6% of SC patients and 18.1% of SS patients had grade 3 to 5 proliferative sickle-cell retinopathy. The prevalence of severe forms of sickle-cell retinopathy was higher among SS men than among SS women (21.7% versus 15.5% ; P<0.05).
  
  
  CONCLUSIONS
  The high prevalence of sickle-cell retinopathy and the potentially severe complications associated with this disease justify screening and therapeutic management by a multidisciplinary team in the setting of a referral center.
authors.affiliation: Service d'ophtalmologie, centre hospitalier intercommunal de Créteil, 40, avenue Verdun, 94000 Créteil, France. nicolas.leveziel@yahoo.fr
authors.forename: N
authors.initials: N
authors.lastname: Leveziel
authors.forename: F
authors.initials: F
authors.lastname: Lalloum
authors.forename: S
authors.initials: S
authors.lastname: Bastuji-Garin
authors.forename: M
authors.initials: M
authors.lastname: Binaghi
authors.forename: D
authors.initials: D
authors.lastname: Bachir
authors.forename: F
authors.initials: F
authors.lastname: Galacteros
authors.forename: E
authors.initials: E
authors.lastname: Souied
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000755:Anemia, Sickle Cell / Q000150:complications*; D003941:Diagnostic Techniques, Ophthalmological; D005260:Female; D006450:Hemoglobin SC Disease / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012164:Retinal Diseases / Q000209:etiology*; D012189:Retrospective Studies; D012720:Severity of Illness Index; D055815:Young Adult