title: Different prognostic value of white blood cell subtypes in patients with acute cerebral infarction.
abstract: OBJECTIVE
  We aimed to investigate the relationship of each white blood cells (WBC) subtype with neurologic severity and outcome in acute stroke.
  
  
  METHODS
  We included 779 patients with first-ever acute cerebral infarction within 72 h after symptom onset. We investigated the association between counts for WBC subtypes in peripheral blood at admission and (1) initial stroke severity; (2) early change in stroke severity within one week; and (3) functional outcome at three months.
  
  
  RESULTS
  Higher total WBC and neutrophil counts were associated with more severe stroke at admission (p<0.001). In contrast, lower lymphocyte counts were associated with a lesser improvement during the first week after admission (p<0.05) and with poor functional outcome at three months (OR=0.706 per 1000 lymphocyte counts/mm(3), p=0.020).
  
  
  CONCLUSIONS
  Our study merits further investigation on the role of each WBC subtype in ischemic injury and different prognostic value of WBC subtypes measured at admission in acute stroke.
authors.affiliation: Department of Neurology, Yonsei University College of Medicine, Seoul, Republic of Korea.
authors.forename: Jinkwon
authors.initials: J
authors.lastname: Kim
authors.forename: Tae-Jin
authors.initials: TJ
authors.lastname: Song
authors.forename: Ji Hye
authors.initials: JH
authors.lastname: Park
authors.forename: Hye Sun
authors.initials: HS
authors.lastname: Lee
authors.forename: Chung Mo
authors.initials: CM
authors.lastname: Nam
authors.forename: Hyo Suk
authors.initials: HS
authors.lastname: Nam
authors.forename: Young Dae
authors.initials: YD
authors.lastname: Kim
authors.forename: Ji Hoe
authors.initials: JH
authors.lastname: Heo
mesh_terms: D000368:Aged; D002544:Cerebral Infarction / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D007962:Leukocytes; D016014:Linear Models; D016015:Logistic Models; D018655:Lymphocyte Count; D008214:Lymphocytes; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009504:Neutrophils; D010343:Patient Admission; D011237:Predictive Value of Tests; D011379:Prognosis; D020127:Recovery of Function; D056910:Republic of Korea; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013997:Time Factors