title: Pyrrole aminoimidazole alkaloid metabiosynthesis with marine sponges Agelas conifera and Stylissa caribica.
abstract: Game-SET-match: Pyrrole aminoimidazole alkaloids (PAIs) are metabiosynthesized from chlorinated analogues of oroidin by cell-free enzyme preparations from PAI-producing sponges. Evidence and implications for the biosynthesis of PAIs include putative single-electron transfers (SETs) that promote C-C bond-forming reactions of precursors.
authors.affiliation: Department of Chemistry and Biochemistry, Skaggs School of Pharmacy and Pharmaceutical Science, University of California, San Diego, La Jolla, 92093, USA.
authors.forename: E Paige
authors.initials: EP
authors.lastname: Stout
authors.forename: Yong-Gang
authors.initials: YG
authors.lastname: Wang
authors.forename: Daniel
authors.initials: D
authors.lastname: Romo
authors.forename: Tadeusz F
authors.initials: TF
authors.lastname: Molinski
mesh_terms: D047230:Agelas / Q000737:chemistry / Q000378:metabolism*; D000470:Alkaloids / Q000096:biosynthesis* / Q000138:chemical synthesis; D000818:Animals; D007093:Imidazoles / Q000138:chemical synthesis / Q000378:metabolism*; D011161:Porifera / Q000737:chemistry / Q000378:metabolism*; D011758:Pyrroles / Q000138:chemical synthesis / Q000378:metabolism*
chemical_list: D000470:Alkaloids; D007093:Imidazoles; D011758:Pyrroles