title: Development of hydrocortisone succinic acid/and 5-fluorouracil/chitosan microcapsules for oral and topical drug deliveries.
abstract: Recently, we demonstrated the safety use of calendula oil/chitosan microcapsules as a carrier for both oral and topical deliveries. We also reported the improved biological activity towards skin cells and Staphylococcus aureus of phyllanthin containing chitosan microcapsules. However, the possibility of both oral and topical applications was still necessary to be further studied. Here we investigated that both oral and topical applications of chitosan-based microcapsules were tested using hydrocortisone succinic acid (HSA) and 5-fluorouracil (5-FU), respectively. The drug loading efficiency, particle size, surface morphology and chemical compositions of both drug loaded microcapsules were confirmed by UV-vis spectrophotometer, particle size analyzer, scanning electron microscope and Fourier transform infrared spectroscopy. The in vitro release studies revealed that both HSA and 5-FU could be released form chitosan microcapsules. The mean adrenocorticotropic hormone concentration in HSA loaded microcapsule mice plasma was detected to be lower than that of water control. One hundred micrograms per milliliter of 5-FU containing microcapsules exhibited a stronger growth inhibition towards skin keratinocytes than that of free 5-FU. In vitro drug delivery model demonstrated the delivery of 5-FU from microcapsule treated textiles into nude mice skin. Further uses of the drug loaded microcapsules may provide an efficiency deliverable tool for both oral and topical applications.
authors.affiliation: Institute of Textiles and Clothing, The Hong Kong Polytechnic University, Hong Kong, China.
authors.forename: Pik-Ling
authors.initials: PL
authors.lastname: Lam
authors.forename: Kenneth Ka-Ho
authors.initials: KK
authors.lastname: Lee
authors.forename: Raymond Siu-Ming
authors.initials: RS
authors.lastname: Wong
authors.forename: Gregory Yin Ming
authors.initials: GY
authors.lastname: Cheng
authors.forename: Shuk Yan
authors.initials: SY
authors.lastname: Cheng
authors.forename: Marcus Chun-Wah
authors.initials: MC
authors.lastname: Yuen
authors.forename: Kim-Hung
authors.initials: KH
authors.lastname: Lam
authors.forename: Roberto
authors.initials: R
authors.lastname: Gambari
authors.forename: Stanton Hon-Lung
authors.initials: SH
authors.lastname: Kok
authors.forename: Chung-Hin
authors.initials: CH
authors.lastname: Chui
mesh_terms: D000284:Administration, Oral; D000287:Administration, Topical; D000818:Animals; D002214:Capsules / Q000737:chemistry*; D048271:Chitosan; D016503:Drug Delivery Systems / Q000379:methods*; D005472:Fluorouracil; D006854:Hydrocortisone; D015603:Keratinocytes / Q000166:cytology; D051379:Mice; D012867:Skin / Q000166:cytology / Q000187:drug effects; D013211:Staphylococcus aureus; D019802:Succinic Acid
chemical_list: D002214:Capsules; D048271:Chitosan; D019802:Succinic Acid; D005472:Fluorouracil; D006854:Hydrocortisone