title: Generation of transplantable striatal projection neurons from human ESCs.
abstract: In this issue of Cell Stem Cell, Ma et al. (2012) report a differentiation protocol for generating striatal projection neurons from human embryonic stem cells with high efficiency. The cells survive transplantation, reconnect striatal circuitry, and restore motor function in a mouse model of striatal neurodegeneration that mimics the central pathohology of Huntington's disease.
authors.affiliation: Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Sweden.
authors.forename: Malin
authors.initials: M
authors.lastname: Parmar
authors.forename: Anders
authors.initials: A
authors.lastname: Björklund