title: A clone of elusive parents: gonadotroph adenoma-female type.
abstract: A 69-year-old woman presented with visual disturbance. Perimetry testing revealed a bitemporal hemianopia. Brain MRI demonstrated a 2.2-cm gadolinium-enhancing pituitary mass. Previously she had been treated for hypothyroidism, hypertension, and dyslipidemia. She had hyperprolactinemia. Endoscopic transsphenoidal debulking improved her visual field defects. Histology showed a chromophobic adenoma. Electron microscopy showed elongated, polar cells with long, slender processes. The small uniform secretory granules were peripherally disposed, collecting heavily within cell processes. Based on electron microscopical characteristics the tumor is consistent with an ACTH-negative female gonadotroph adenoma. The parent cell of this rare variant of a pituitary adenoma is yet unknown.
authors.affiliation: Department of Neuropathology, The Walton Centre for Neurology & Neurosurgery NHS Foundation Trust, Lower Lane, Liverpool L9 7LJ, UK. a.baborie@liv.ac.uk
authors.forename: A
authors.initials: A
authors.lastname: Baborie
authors.forename: C
authors.initials: C
authors.lastname: Daousi
authors.forename: M
authors.initials: M
authors.lastname: Javadpour
authors.forename: K
authors.initials: K
authors.lastname: Das
authors.forename: H
authors.initials: H
authors.lastname: White
authors.forename: I
authors.initials: I
authors.lastname: Macfarlane
authors.forename: K
authors.initials: K
authors.lastname: Kovacs
authors.forename: E
authors.initials: E
authors.lastname: Horvath
mesh_terms: D000236:Adenoma / Q000150:complications / Q000648:ultrastructure*; D000368:Aged; D002478:Cells, Cultured; D005260:Female; D052681:Gonadotrophs / Q000473:pathology; D006423:Hemianopsia / Q000209:etiology; D006801:Humans; D008854:Microscopy, Electron; D010911:Pituitary Neoplasms / Q000150:complications / Q000648:ultrastructure*; D059705:Polar Bodies / Q000648:ultrastructure*