title: Lisuride reduces involuntary periodic leg movements in spinocerebellar ataxia type 2 patients.
abstract: Periodic leg movements (PLMs) are a common sleep disorder in spinocerebellar ataxia type 2 (SCA2) being associated to higher disease severity and altered sleep patterns. To assess the efficacy and safety of lisuride for the treatment of PLMs in SCA2 patients, an open-label clinical trial was conducted in 12 SCA2 patients suffering from PLMs associated to other subjective sleep complaints. All subjects received 0.1 mg of oral lisuride daily for 4 weeks. Primary outcome measure was the change of PLMs index. Changes in the subjective sleep quality, other polysomnographical sleep parameters, Scale for the Assessment and Rating of Ataxia score, and saccadic velocity were assessed as secondary outcome parameters. Safety assessments included hemoglobin, hematocrit, cholesterol, creatinine, and TGP. A significant decrease in both the PLMs index and R stage latency were observed during the treatment, associated to subjective improvement of frequent awakenings, early insomnia, restless leg syndrome, and nocturnal limb paresthesias in most cases. Ataxia score and saccadic pathology were unchanged. No significantly adverse events were observed. Our study suggests the efficacy of dopamine agonist therapy in the treatment of PLMs in SCA2, improving various subjective sleep complaints. These findings serve to promote the adequate management of sleep-related disorders in SCA2, which could improve the life quality of the patients.
authors.affiliation: Centre for the Research and Rehabilitation of Hereditary Ataxias, Carretera Central Km 5 1/2 Reparto Edecio Pérez, 80100, Holguín, Cuba. cirahsca2@cristal.hlg.sld.cu
authors.forename: Luis
authors.initials: L
authors.lastname: Velázquez-Pérez
authors.forename: Roberto
authors.initials: R
authors.lastname: Rodríguez-Labrada
authors.forename: Lázaro
authors.initials: L
authors.lastname: Álvarez-González
authors.forename: Raúl
authors.initials: R
authors.lastname: Aguilera-Rodríguez
authors.forename: Mario
authors.initials: M
authors.lastname: Álvarez Sánchez
authors.forename: Nalia
authors.initials: N
authors.lastname: Canales-Ochoa
authors.forename: Lourdes
authors.initials: L
authors.lastname: Galicia Polo
authors.forename: Reyes
authors.initials: R
authors.lastname: Haro-Valencia
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Medrano-Montero
authors.forename: Yaimeé
authors.initials: Y
authors.lastname: Vázquez-Mojena
authors.forename: Arnoy
authors.initials: A
authors.lastname: Peña-Acosta
authors.forename: Annelié
authors.initials: A
authors.lastname: Estupiñán-Rodríguez
authors.forename: Noemí
authors.initials: N
authors.lastname: Rodríguez Pupo
mesh_terms: D000328:Adult; D018491:Dopamine Agonists / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007866:Leg / Q000503:physiopathology*; D008090:Lisuride / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D017286:Polysomnography / Q000379:methods; D012148:Restless Legs Syndrome / Q000188:drug therapy* / Q000209:etiology; D012890:Sleep / Q000502:physiology; D020754:Spinocerebellar Ataxias / Q000150:complications / Q000188:drug therapy*
chemical_list: D018491:Dopamine Agonists; D008090:Lisuride