title: CCL3L gene copy number and survival in an HIV-1 infected Zimbabwean population.
abstract: The C-C motif chemokine ligand 3-like (CCL3L) protein is a potent chemoattractant which by binding to C-C chemokine receptor type 5 (CCR5) inhibits human immunodeficiency virus (HIV) entry. Copy number variation (CNV) of the CCL3L has been shown to be associated with HIV susceptibility and progression to AIDS, but these results have been inconsistent. We examined a Zimbabwean study population for an association of CCL3L CNV with HIV status, progression (CD4 T-cells and viral load), and survival. Another aim was to investigate the possible effects of CCL3L CNV on CCL3 protein concentration. A treatment-naïve cohort, which included 153 HIV infected and 159 HIV uninfected individuals, was followed for up to 4.3 years. The CNV of the CCL3L was determined by duplex real-time polymerase chain reaction. We found no association between four CCL3L CNV strata and HIV status (P=0.7), CD4 T-cell count (P=0.9), viral load (P=0.9), or CCL3 protein levels (P=1.0). Survival among the HIV infected individuals did not differ according to CCL3L copy number. In this cohort, CCL3L CNV did not affect HIV status, pathogenesis, or survival.
authors.affiliation: Department of Clinical Immunology, Copenhagen University Hospital, Denmark. margit.h.larsen@rh.regionh.dk
authors.forename: Margit Hørup
authors.initials: MH
authors.lastname: Larsen
authors.forename: Lise Wegner
authors.initials: LW
authors.lastname: Thørner
authors.forename: Rutendo
authors.initials: R
authors.lastname: Zinyama
authors.forename: Janne
authors.initials: J
authors.lastname: Amstrup
authors.forename: Per
authors.initials: P
authors.lastname: Kallestrup
authors.forename: Jan
authors.initials: J
authors.lastname: Gerstoft
authors.forename: Exnevia
authors.initials: E
authors.lastname: Gomo
authors.forename: Christian
authors.initials: C
authors.lastname: Erikstrup
authors.forename: Henrik
authors.initials: H
authors.lastname: Ullum
mesh_terms: D018791:CD4 Lymphocyte Count; D019742:Chemokines, CC / Q000235:genetics*; D015331:Cohort Studies; D056915:DNA Copy Number Variations; D015658:HIV Infections / Q000453:epidemiology / Q000235:genetics*; D015497:HIV-1; D006801:Humans; D053208:Kaplan-Meier Estimate; D015996:Survival Rate; D019562:Viral Load; D015030:Zimbabwe / Q000453:epidemiology
chemical_list: C492767:CCL3L1 protein, human; D019742:Chemokines, CC