title: Nanomedicine for intracellular therapy.
abstract: Intracellular pathogens like Salmonella evade host phagocytic killing by various mechanisms. Classical antimicrobial therapy requires multiple dosages and frequent administration of drugs for a long duration. Intracellular delivery of antimicrobials using nanoparticle may effectively devise therapies for bacterial infections. This review will address the mechanisms used by Salmonella to avoid host pathogenic killing, reasons for therapeutic failure and advances in nanoparticle drug delivery technology for efficient intracellular bacterial clearance.
authors.affiliation: Department of Radiology and Imaging Sciences, National Institutes of Health, Bethesda, MD 20892, USA. ashishvet06@gmail.com
authors.forename: Ashish
authors.initials: A
authors.lastname: Ranjan
authors.forename: Nikorn
authors.initials: N
authors.lastname: Pothayee
authors.forename: Mohamed N
authors.initials: MN
authors.lastname: Seleem
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Boyle
authors.forename: Ramanathan
authors.initials: R
authors.lastname: Kasimanickam
authors.forename: Judy S
authors.initials: JS
authors.lastname: Riffle
authors.forename: Nammalwar
authors.initials: N
authors.lastname: Sriranganathan
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D016503:Drug Delivery Systems / Q000379:methods*; D054884:Host-Pathogen Interactions; D006801:Humans; D042541:Intracellular Space / Q000378:metabolism / Q000382:microbiology; D050997:Nanomedicine / Q000379:methods*; D053758:Nanoparticles / Q000008:administration & dosage; D012475:Salmonella / Q000502:physiology*; D012480:Salmonella Infections / Q000188:drug therapy* / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents