title: Trends and distribution of oral and pharyngeal lymphoma in Israel.
abstract: OBJECTIVE
  To describe the distribution and trends of oral and pharyngeal lymphoma cases in Israel.
  
  
  METHODS
  Incidence rates were derived from the Israel National Cancer Registry and included all registered data from 1970 to 2006. Oral lymphoma included the tongue, mouth, salivary glands, tonsils, and pharynx. Morphological description was according to WHO classification of lymphoid neoplasms.
  
  
  RESULTS
  A total of 670 cases were diagnosed, mean age 59.5 years, half were over 65 years old. Tonsils were the most prevalent site of involvement (36.0%), followed by the pharyngeal region and salivary glands. Over the years, the prevalence of lymphoma in salivary glands increased by 49%, whereas in tonsils lymphoma decreased by 28.6%. The overall 5-year survival rate was 57% with best rates among young people.
  
  
  CONCLUSIONS
  The correlation of survival, type of lymphoma and age, was similar to extra-oral lymphoma. A trend of increased cases in the parotid region, dissimilar to other oral sites, raises a question of possible external factors or an increase in autoimmune diseases. Head and neck clinicians should be aware of different sites, types, and prognoses for the different age groups.
authors.affiliation: Department of Community Dentistry, University-Hadassah School of Dental Medicine, Jerusalem, Israel. aviz@hadassah.org.il
authors.forename: A
authors.initials: A
authors.lastname: Zini
authors.forename: D
authors.initials: D
authors.lastname: Atia-Joachim
authors.forename: H D
authors.initials: HD
authors.lastname: Sgan-Cohen
authors.forename: D
authors.initials: D
authors.lastname: Lavie
authors.forename: R
authors.initials: R
authors.lastname: Czerninski
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000704:Analysis of Variance; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D015994:Incidence; D007557:Israel / Q000453:epidemiology; D053208:Kaplan-Meier Estimate; D016015:Logistic Models; D008223:Lymphoma / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000453:epidemiology*; D010610:Pharyngeal Neoplasms / Q000453:epidemiology*; D015995:Prevalence; D055815:Young Adult