title: Implantation of a newly developed direct optic nerve electrode device for artificial vision in rabbits.
abstract: The purpose of this study was to investigate the surgical procedures involved in the implantation of a newly developed direct optic nerve electrode device for inducing artificial vision. The electrode device comprised seven wire stimulation electrodes and a return electrode (diameter 50 μm), one manipulation rod (diameter 100 μm), and a cylindrical silicone board (diameter 2.0 mm). The stimulation electrodes and the manipulation rod protruded through the board to allow implantation of the electrode tips into the optic disc of the rabbit eye. The surgical procedures required to insert the device into the vitreous cavity and implant the device into the optic disc were evaluated. When the electrodes were stimulated, electrically evoked potentials (EEPs) were recorded at the visual cortex. The electrode device was inserted into the vitreous cavity with no damage using a trocar through a scleral incision. The device was easily manipulated using vitreoretinal forceps in the vitreous cavity, and the electrode tips were implanted into the optic disc in a single insertion after vitrectomy. When electrical stimulation was applied, EEPs were recorded from all electrode pairs. The newly developed electrode device was inserted into the eye and implanted into the optic nerve disc smoothly and safely, suggesting that these surgical procedures are useful for our artificial vision system.
authors.affiliation: Department of Ophthalmology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, E-7, Suita, Osaka 565-0871, Japan. sakaguh@ophthal.med.osaka-u.ac.jp
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Sakaguchi
authors.forename: Motohiro
authors.initials: M
authors.lastname: Kamei
authors.forename: Kentaro
authors.initials: K
authors.lastname: Nishida
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Terasawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Fujikado
authors.forename: Motoki
authors.initials: M
authors.lastname: Ozawa
authors.forename: Kohji
authors.initials: K
authors.lastname: Nishida
mesh_terms: D000818:Animals; D004558:Electric Stimulation / Q000295:instrumentation; D004567:Electrodes, Implanted; D005074:Evoked Potentials, Visual / Q000502:physiology*; D009900:Optic Nerve / Q000502:physiology / Q000601:surgery*; D011817:Rabbits; D014785:Vision, Ocular / Q000502:physiology*; D014793:Visual Cortex / Q000502:physiology*