title: Synthesis, cytotoxicity and apoptosis of cyclotriphosphazene compounds as anti-cancer agents.
abstract: In the present study, a number of new dispirobino and dispiroansa spermine derivatives of cyclotriphosphazene (8-10, 13) were synthesized and characterized by elemental analysis, mass spectrometry, (1)H and (31)P NMR spectroscopy. At first, in vitro cytotoxic activity of cyclotriphosphazene compounds (1-14) against HT-29 (human colon adenocarcinoma), Hep2 (Human epidermoid larynx carcinoma), and Vero (African green monkey kidney) cell lines was investigated. Our study showed that most of these compounds stimulate apoptosis and they have cytotoxic effects for HT-29 and Hep2 cells. Additionally, these compounds (1-14) were investigated for their antibacterial activity against gram-positive (Staphylococcus aureus), gram-negative (Escherichia coli, Pseudomonas aeruginosa) bacteria and for their antifungal activity against Candida albicans, and were shown to be inactive.
authors.affiliation: Department of Biology, Faculty of Art and Science, Amasya University, 05100 Amasya, Turkey. yildirimt55@gmail.com
authors.forename: Tuba
authors.initials: T
authors.lastname: Yıldırım
authors.forename: Kemal
authors.initials: K
authors.lastname: Bilgin
authors.forename: Gönül Yenilmez
authors.initials: GY
authors.lastname: Çiftçi
authors.forename: Esra Tanrıverdi
authors.initials: ET
authors.lastname: Eçik
authors.forename: Elif
authors.initials: E
authors.lastname: Şenkuytu
authors.forename: Yıldız
authors.initials: Y
authors.lastname: Uludağ
authors.forename: Leman
authors.initials: L
authors.lastname: Tomak
authors.forename: Adem
authors.initials: A
authors.lastname: Kılıç
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D017209:Apoptosis / Q000187:drug effects*; D001419:Bacteria / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D002460:Cell Line; D060326:Chemistry Techniques, Synthetic; D006801:Humans; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D017553:Phosphorus Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity
chemical_list: D000970:Antineoplastic Agents; D017553:Phosphorus Compounds