title: Synthesis of ureidomuraymycidine derivatives for structure-activity relationship studies of muraymycins.
abstract: One of the key constituents of the muraymycins is the 6-membered cyclic guanidine,  (2S,3S)-muraymycidine (or epi-capreomycidine). In order to diversify the structure of the oligopeptide moiety of the muraymycins for thorough structure-activity relationship studies, we have developed a highly stereoselective synthesis of ureidomuraymycidine derivatives with the lactone 4a.
authors.affiliation: Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, 881 Madison, Memphis, Tennessee 38163-0001, USA.
authors.forename: Bilal A
authors.initials: BA
authors.lastname: Aleiwi
authors.forename: Christopher M
authors.initials: CM
authors.lastname: Schneider
authors.forename: Michio
authors.initials: M
authors.lastname: Kurosu
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D001120:Arginine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014508:Urea / Q000031:analogs & derivatives* / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D009705:Nucleosides; D010455:Peptides; C463580:capreomycidine; C549119:muraymycin D2; D014508:Urea; D001120:Arginine