title: Contribution of cerebellar sensorimotor adaptation to hippocampal spatial memory.
abstract: Complementing its primary role in motor control, cerebellar learning has also a bottom-up influence on cognitive functions, where high-level representations build up from elementary sensorimotor memories. In this paper we examine the cerebellar contribution to both procedural and declarative components of spatial cognition. To do so, we model a functional interplay between the cerebellum and the hippocampal formation during goal-oriented navigation. We reinterpret and complete existing genetic behavioural observations by means of quantitative accounts that cross-link synaptic plasticity mechanisms, single cell and population coding properties, and behavioural responses. In contrast to earlier hypotheses positing only a purely procedural impact of cerebellar adaptation deficits, our results suggest a cerebellar involvement in high-level aspects of behaviour. In particular, we propose that cerebellar learning mechanisms may influence hippocampal place fields, by contributing to the path integration process. Our simulations predict differences in place-cell discharge properties between normal mice and L7-PKCI mutant mice lacking long-term depression at cerebellar parallel fibre-Purkinje cell synapses. On the behavioural level, these results suggest that, by influencing the accuracy of hippocampal spatial codes, cerebellar deficits may impact the exploration-exploitation balance during spatial navigation.
authors.affiliation: Laboratory of Neurobiology of Adaptive Processes, UMR 7102, CNRS - University Pierre and Marie Curie, Paris, France.
authors.forename: Jean-Baptiste
authors.initials: JB
authors.lastname: Passot
authors.forename: Denis
authors.initials: D
authors.lastname: Sheynikhovich
authors.forename: Éléonore
authors.initials: É
authors.lastname: Duvelle
authors.forename: Angelo
authors.initials: A
authors.lastname: Arleo
mesh_terms: D000223:Adaptation, Psychological; D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal; D002531:Cerebellum / Q000502:physiology*; D003198:Computer Simulation; D006624:Hippocampus / Q000502:physiology*; D036881:Long-Term Synaptic Depression / Q000235:genetics; D018782:Maze Learning; D008568:Memory; D051379:Mice; D008822:Mice, Transgenic; D008959:Models, Neurological; D009419:Nerve Tissue Proteins / Q000235:genetics; D011493:Protein Kinase C / Q000235:genetics
chemical_list: D009419:Nerve Tissue Proteins; C091104:Purkinje cell protein L7; D011493:Protein Kinase C