title: Human gastric cancer development with TNF-α-inducing protein secreted from Helicobacter pylori.
abstract: TNF-α-inducing protein (Tipα) is a unique carcinogenic factor of Helicobacter pylori, which is secreted into culture broth. The biological activities of Tipα and deletion mutant were studied. Tipα protein specifically binds to cell-surface nucleolin and then enters the gastric cancer cells, where TNF-α and chemokine gene expressions are induced by NF-κB activation. Nucleolin localizes on the surface of gastric cancer cells, and interaction between Tipα and cell-surface nucleolin causes a cancer-oriented microenvironment that increases the risk of gastric cancer. This paper discusses a new mechanism of gastric cancer development with H. pylori and provides a new preventive strategy.
authors.affiliation: Research Institute for Clinical Oncology, Saitama Cancer Center, Japan. masami@cancer-c.pref.saitama.jp
authors.forename: Masami
authors.initials: M
authors.lastname: Suganuma
authors.forename: Tatsuro
authors.initials: T
authors.lastname: Watanabe
authors.forename: Kensei
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Takahashi
authors.forename: Hirota
authors.initials: H
authors.lastname: Fujiki
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000378:metabolism*; D002471:Cell Transformation, Neoplastic; D018925:Chemokines / Q000235:genetics; D015870:Gene Expression; D006801:Humans; D008969:Molecular Sequence Data; D058990:Molecular Targeted Therapy; D016328:NF-kappa B / Q000378:metabolism; D010750:Phosphoproteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D016601:RNA-Binding Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D013274:Stomach Neoplasms / Q000209:etiology* / Q000378:metabolism / Q000628:therapy; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics; D000097796:Nucleolin
chemical_list: D001426:Bacterial Proteins; D018925:Chemokines; D016328:NF-kappa B; D010750:Phosphoproteins; D016601:RNA-Binding Proteins; D014409:Tumor Necrosis Factor-alpha; D000097796:Nucleolin; C505332:Tipalpha protein, Helicobacter pylori