title: Surface acoustic wave nebulization produces ions with lower internal energy than electrospray ionization.
abstract: Surface acoustic wave nebulization (SAWN) has recently been reported as a novel method to transfer non-volatile analytes directly from solution to the gas phase for mass spectrometric analysis. Here we present a comparison of the survival yield of SAWN versus electrospray ionization (ESI) produced ions. A series of substituted benzylpyridinium (BzPy) compounds were utilized to measure ion survival yield from which ion energetics were inferred. We also estimated bond dissociation energies using higher level quantum chemical calculations than previously reported for BzPy ions. Additionally, the effects on BzPy precursor ion survival of SAWN operational parameters such as inlet capillary temperature and solution flow-rate were investigated. Under all conditions tested, SAWN-generated BzPy ions displayed a higher tendency for survival and thus have lower internal energies than those formed by ESI.
authors.affiliation: Department of Chemistry, University of Washington, Seattle, WA 98195-1700, USA.
authors.forename: Yue
authors.initials: Y
authors.lastname: Huang
authors.forename: Sung Hwan
authors.initials: SH
authors.lastname: Yoon
authors.forename: Scott R
authors.initials: SR
authors.lastname: Heron
authors.forename: Christophe D
authors.initials: CD
authors.lastname: Masselon
authors.forename: J Scott
authors.initials: JS
authors.lastname: Edgar
authors.forename: František
authors.initials: F
authors.lastname: Tureček
authors.forename: David R
authors.initials: DR
authors.lastname: Goodlett
mesh_terms: D001593:Benzyl Compounds / Q000737:chemistry; D055598:Chemical Phenomena; D003508:Cycloheptanes / Q000737:chemistry; D005740:Gases / Q000737:chemistry*; D007477:Ions / Q000737:chemistry*; D056656:Lab-On-A-Chip Devices; D009330:Nebulizers and Vaporizers; D011726:Pyridinium Compounds / Q000737:chemistry; D013016:Sound; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D013696:Temperature
chemical_list: D001593:Benzyl Compounds; D003508:Cycloheptanes; D005740:Gases; D007477:Ions; D011726:Pyridinium Compounds; C430852:tropylium