title: Simultaneous determination of L-ascorbic acid, dopamine and uric acid with gold nanoparticles-β-cyclodextrin-graphene-modified electrode by square wave voltammetry.
abstract: Graphene decorated with gold nanoparticles (AuNPs-β-CD-Gra) has been synthesized by in situ thermal reduction of graphene oxide and HAuCl(4) with β-cyclodextrin (β-CD) under alkaline condition. The AuNPs-β-CD-Gra product was well characterized by infrared spectroscopy, X-ray powder diffraction, scanning electron microscopy, high-resolution transmission electron microscopy, and selected area electron diffraction. This material was used to fabricate an AuNPs-β-CD-Gra-modified glassy carbon electrode (GCE) which showed excellent electro-oxidation of l-ascorbic acid (AA), dopamine (DA) and uric acid (UA) in 0.10 M NaH(2)PO(4)-HCl buffer solution (pH 2.0) by square wave voltammetry (SWV). Three well-resolved oxidation peaks of AA and DA and UA were obtained. The AuNPs-β-CD-Gra/GCE exhibits linear responses to AA, DA and UA in the ranges 30-2000, 0.5-150 and 0.5-60 μM, respectively. The detection limits (based on S/N=3 and preconcentration time=3.0 min) for AA, DA and UA are 10, 0.15 and 0.21 μM, respectively. The AuNPs-β-CD-Gra/GCE has been successfully applied to determine UA in human urine with satisfactory results. Our work provides a simple, convenient and green route to synthesize AuNPs on Gra which is potentially useful in electroanalysis.
authors.affiliation: College of Chemistry, Sichuan University, 29 Wangjiang Road, Chengdu 610064, PR China.
authors.forename: Xianqing
authors.initials: X
authors.lastname: Tian
authors.forename: Changming
authors.initials: C
authors.lastname: Cheng
authors.forename: Hongyan
authors.initials: H
authors.lastname: Yuan
authors.forename: Juan
authors.initials: J
authors.lastname: Du
authors.forename: Dan
authors.initials: D
authors.lastname: Xiao
authors.forename: Shunping
authors.initials: S
authors.lastname: Xie
authors.forename: Martin M F
authors.initials: MM
authors.lastname: Choi
mesh_terms: D001205:Ascorbic Acid / Q000032:analysis* / Q000737:chemistry / Q000652:urine; D002712:Chlorides / Q000737:chemistry; D004298:Dopamine / Q000032:analysis* / Q000737:chemistry / Q000652:urine; D004563:Electrochemistry / Q000295:instrumentation / Q000379:methods*; D004566:Electrodes; D006046:Gold / Q000737:chemistry*; D017612:Gold Compounds / Q000737:chemistry; D006108:Graphite / Q000737:chemistry*; D055772:Green Chemistry Technology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D053768:Metal Nanoparticles / Q000737:chemistry; D008958:Models, Molecular; D008968:Molecular Conformation; D010084:Oxidation-Reduction; D013696:Temperature; D013997:Time Factors; D014527:Uric Acid / Q000032:analysis* / Q000737:chemistry / Q000652:urine; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D002712:Chlorides; D017612:Gold Compounds; D047392:beta-Cyclodextrins; D014527:Uric Acid; D006046:Gold; D006108:Graphite; C024568:gold tetrachloride, acid; C031215:betadex; D001205:Ascorbic Acid; D004298:Dopamine