title: An overview of intracellular interactions between immunodeficiency viruses and their hosts.
abstract: Many studies have documented how extensively HIV-1 and related viruses interact with host cells. Virus-host interactions are of two conceptual types. First, viruses have evolved to make use of numerous host-cell functions to facilitate their own replication. Second, hosts have evolved a number of activities to inhibit virus replication. Understanding the scope and details of HIV-host interactions has been an extraordinary rich scientific endeavor, and in addition to their biomedical importance, studies in this area have established HIV as a model system in virology. Here, I present an overview of how HIV-1 interacts with some key host cell factors during its replication cycle.
authors.affiliation: Laboratory of Retrovirology, Howard Hughes Medical Institute, Aaron Diamond AIDS Research Center, The Rockefeller University, New York, NY 10016, USA. pbienias@adarc.org
authors.forename: Paul D
authors.initials: PD
authors.lastname: Bieniasz
mesh_terms: D015658:HIV Infections / Q000635:transmission / Q000821:virology*; D015497:HIV-1 / Q000235:genetics* / Q000472:pathogenicity; D054884:Host-Pathogen Interactions; D006801:Humans / Q000821:virology; D008954:Models, Biological; D014779:Virus Replication