title: Quantitative magnetic analysis reveals ferritin-like iron as the most predominant iron-containing species in the murine Hfe-haemochromatosis.
abstract: Quantitative analysis of the temperature dependent AC magnetic susceptibility of freeze-dried mouse tissues from an Hfe hereditary haemochromatosis disease model indicates that iron predominantly appears biomineralised, like in the ferritin cores, in the liver, the spleen and duodenum. The distribution of the amount of ferritin-like iron between genders and genotypes coincides with that of elemental iron and nonheme iron. Importantly, the so-called paramagnetic iron, a quantity also determined from the magnetic data and indicative of nonmineralised iron forms, appears only marginally increased when iron overload takes place.
authors.affiliation: School of Physics, M013, The University of Western Australia, 6009, Crawley, Australia. lucia.gutierrez@uwa.edu.au
authors.forename: Lucía
authors.initials: L
authors.lastname: Gutiérrez
authors.forename: Maja
authors.initials: M
authors.lastname: Vujić Spasić
authors.forename: Martina U
authors.initials: MU
authors.lastname: Muckenthaler
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Lázaro
mesh_terms: D000818:Animals; D003627:Data Interpretation, Statistical; D004386:Duodenum / Q000737:chemistry / Q000378:metabolism; D005260:Female; D005293:Ferritins / Q000032:analysis* / Q000378:metabolism; D006432:Hemochromatosis / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007501:Iron / Q000032:analysis* / Q000378:metabolism; D007668:Kidney / Q000737:chemistry / Q000378:metabolism; D008099:Liver / Q000737:chemistry / Q000378:metabolism; D060328:Magnetic Phenomena; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009206:Myocardium / Q000737:chemistry / Q000378:metabolism; D053758:Nanoparticles / Q000737:chemistry; D009928:Organ Specificity; D013054:Spectrophotometry, Atomic; D013154:Spleen / Q000737:chemistry / Q000378:metabolism; D013696:Temperature; D014018:Tissue Distribution
chemical_list: D006454:Hemoglobins; D005293:Ferritins; D007501:Iron