title: Renal denervation in human hypertension: mechanisms, current findings, and future prospects.
abstract: Denervating the human kidney to improve blood pressure control is an old therapeutic concept first applied on a larger scale by surgeons in the 1920s. With the advent of modern pharmacology and the development of powerful drugs to lower blood pressure, approaches to directly target the sympathetic nerves were more or less abandoned. Over the past 2-3 years, however, we have witnessed enormous renewed interest in novel and minimally invasive device-based approaches to specifically target the renal nerves. The enthusiasm is fueled by promising results from proof-of-concept studies and clinical trials demonstrating convincing blood pressure-lowering effects in the majority of treated patients, and perhaps even more so by observations indicating potential additional benefits relating to common comorbidities of hypertension, such as impaired glucose metabolism, renal impairment, left ventricular hypertrophy, and others. Herein we review the current findings and assess whether these high hopes are justified.
authors.affiliation: Neurovascular Hypertension and Kidney Disease Laboratory, Baker IDI Heart and Diabetes Institute, P.O. Box 6492, St. Kilda Road Central, Melbourne, Victoria, 8008, Australia. markus.schlaich@bakeridi.edu.au
authors.forename: Markus P
authors.initials: MP
authors.lastname: Schlaich
authors.forename: Dagmara
authors.initials: D
authors.lastname: Hering
authors.forename: Paul A
authors.initials: PA
authors.lastname: Sobotka
authors.forename: Henry
authors.initials: H
authors.lastname: Krum
authors.forename: Murray D
authors.initials: MD
authors.lastname: Esler
mesh_terms: D003714:Denervation / Q000379:methods*; D006801:Humans; D006973:Hypertension / Q000601:surgery*; D007668:Kidney / Q000294:innervation* / Q000601:surgery; D013562:Sympathectomy / Q000379:methods*