title: Silver(I) complexes of 9-anthracenecarboxylic acid and imidazoles: synthesis, structure and antimicrobial activity.
abstract: [Ag(2)(9-aca)(2)] (1) (9-acaH = 9-anthracenecarboxylic acid) reacts with a series of imidazoles to give [Ag(imidH)(2.3)(CH(3)CN)(0.7)](9-aca) (3), [Ag(6)(imidH)(4)(9-aca)(6)(MeOH)(2)] (4), {[Ag(1-Me-imid)(2)](2)[Ag(4)(9-aca)(6)]} (5), {[Ag(1-Bu-imid)(2)](2)[Ag(4)(9-aca)(6)]} (6) and [Ag(apim)](9-aca)·H(2)O (7) (imidH = imidazole; 1-Me-imid = 1-methylimidazole; 1-Bu-imid = 1-butylimidazole; apim = 1-(3-aminopropyl)imidazole). The mononuclear complex 3, hexanuclear 4-6, and polymeric 7, were all characterised using X-ray crystallography. While many of the complexes possess excellent in vitro antifungal and antibacterial activities they are, unanimously, more effective against fungal cells. The insect, Galleria mellonella, can survive high doses of the Ag(i) complexes administered in vivo, and a number of the complexes offer significant protection to larvae infected with a lethal dose of pathogenic Candida albicans cells.
authors.affiliation: Department of Chemistry, National University of Ireland, Maynooth, Co. Kildare, Ireland.
authors.forename: Malachy
authors.initials: M
authors.lastname: McCann
authors.forename: Robert
authors.initials: R
authors.lastname: Curran
authors.forename: Marcia
authors.initials: M
authors.lastname: Ben-Shoshan
authors.forename: Vickie
authors.initials: V
authors.lastname: McKee
authors.forename: Asif Ali
authors.initials: AA
authors.lastname: Tahir
authors.forename: Michael
authors.initials: M
authors.lastname: Devereux
authors.forename: Kevin
authors.initials: K
authors.lastname: Kavanagh
authors.forename: Bernadette S
authors.initials: BS
authors.lastname: Creaven
authors.forename: Andrew
authors.initials: A
authors.lastname: Kellett
mesh_terms: D000818:Animals; D000873:Anthracenes / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D002176:Candida albicans / Q000187:drug effects; D060326:Chemistry Techniques, Synthetic; D004926:Escherichia coli / Q000187:drug effects; D007093:Imidazoles / Q000737:chemistry*; D007915:Lepidoptera / Q000187:drug effects; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D012834:Silver / Q000737:chemistry*
chemical_list: D000873:Anthracenes; D000890:Anti-Infective Agents; D007093:Imidazoles; D009942:Organometallic Compounds; D012834:Silver; C010030:9-anthroic acid