title: Enantioselective synthesis of optically active cis-β-thio-α-amino acid derivatives through an organocatalytic cascade thio-Michael/ring opening process.
abstract: Non-naturally enantioenriched cis-β-thio-α-amino acid derivatives were synthesized through one pot, cascade thio-Michael/ring opening reaction of aromatic thiols with (Z)-olefinic azlactones in good yields with high levels of diastereoselectivities and enantioselectivities, which was catalyzed by a chiral bifunctional thiourea-tertiary amine catalyst.
authors.affiliation: Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, PR China.
authors.forename: Zhi-Cong
authors.initials: ZC
authors.lastname: Geng
authors.forename: Ning
authors.initials: N
authors.lastname: Li
authors.forename: Jian
authors.initials: J
authors.lastname: Chen
authors.forename: Xiao-Fei
authors.initials: XF
authors.lastname: Huang
authors.forename: Bin
authors.initials: B
authors.lastname: Wu
authors.forename: Guo-Gui
authors.initials: GG
authors.lastname: Liu
authors.forename: Xing-Wang
authors.initials: XW
authors.lastname: Wang
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis* / Q000737:chemistry; D001372:Aza Compounds / Q000737:chemistry; D002384:Catalysis; D007783:Lactones / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D013890:Thiourea / Q000737:chemistry
chemical_list: D000596:Amino Acids; D001372:Aza Compounds; D007783:Lactones; D013438:Sulfhydryl Compounds; D013890:Thiourea