title: Anti-H-2 antibodies induced by syngeneic immunization.
abstract: Abstract. Alloreactive cytotoxic antibodies were induced in BALB/c mice by syngeneic immunization with normal lymphoid cells. Sixteen out of 41 mice produced antibodies with distinct anti-H-2 specificity. Anti-Kk antibodies were present in all positive sera, but the individual sera produced different reactivity patterns when tested on a panel of H-2 haplotypes. Absorption and immunoprecipitation experiments confirmed the H-2 specificity of the syngeneic sera. We hypothesize that virus-modified H-2d structures have triggered alloreactive B-cell clones to produce anti-H-2 antibodies.
authors.affiliation: Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: P
authors.initials: P
authors.lastname: Iványi
authors.forename: P
authors.initials: P
authors.lastname: van Mourik
authors.forename: M
authors.initials: M
authors.lastname: Breuning
authors.forename: C J
authors.initials: CJ
authors.lastname: Melief
mesh_terms: D000818:Animals; D000918:Antibody Specificity / Q000276:immunology*; D000920:Antibody-Dependent Cell Cytotoxicity / Q000276:immunology*; D000961:Antilymphocyte Serum / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D003429:Cross Reactions; D006183:H-2 Antigens / Q000276:immunology*; D006239:Haplotypes; D007114:Immunization / Q000379:methods*; D007518:Isoantibodies / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C
chemical_list: D000961:Antilymphocyte Serum; D006183:H-2 Antigens; D007518:Isoantibodies; C030036:anti-H-2 antibodies