title: Human parvovirus PARV4 in plasma pools of Chinese origin.
abstract: Human parvovirus 4 (PARV4) is present in blood and blood products. As the presence and levels of PARV4 in Chinese source plasma pools have never been determined, we implemented real-time quantitative PCR to investigate the presence of PARV4 in source plasma pools in China. Results showed that 26·15% (51/195) of lots tested positive for PARV4. The amounts of DNA ranged from 2·83 × 10(3) copies/ml to 2·35×10(7) copies/ml plasma. The high level of PARV4 in plasma pools may pose a potential risk to recipients. Further studies on the pathogenesis of PARV4 are urgently required.
authors.affiliation: Laboratory for Viral Safety of National Centre of Biomedical Analysis, Institute of Transfusion Medicine, Academy of Military Medical Sciences, Beijing, China.
authors.forename: Y-Y
authors.initials: YY
authors.lastname: Ma
authors.forename: Y
authors.initials: Y
authors.lastname: Guo
authors.forename: X
authors.initials: X
authors.lastname: Zhao
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
authors.forename: M-M
authors.initials: MM
authors.lastname: Lv
authors.forename: Q-P
authors.initials: QP
authors.lastname: Yan
authors.forename: J-G
authors.initials: JG
authors.lastname: Zhang
mesh_terms: D044466:Asian People; D006801:Humans; D010322:Parvoviridae Infections / Q000097:blood* / Q000235:genetics / Q000821:virology*; D017992:Parvovirus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D060888:Real-Time Polymerase Chain Reaction