title: Phosphorylation meets proteolysis.
abstract: Phosphorylation is a reversible post-translational modification that regulates many proteins and enzymes, including proteases, as shown by two recent publications. Huang and colleagues and Velázquez-Delgado and Hardy (this issue of Structure) describe how phosphorylation activates the protease activity of the deubiquitinating enzyme DUBA and how it inhibits caspase-6, respectively.
authors.affiliation: Novartis Institutes for BioMedical Research, Forum 1, Novartis Campus, CH-4002 Basel, Switzerland. martin.renatus@novartis.com
authors.forename: Martin
authors.initials: M
authors.lastname: Renatus
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Farady