title: Iatrogenic hyperadrenocorticism, calcinosis cutis, and myocardial infarction in a dog treated for IMT.
abstract: An 8 yr old male English bulldog receiving treatment for immune-mediated thrombocytopenia was diagnosed with calcinosis cutis 90 days after initiation of corticosteroid therapy. Twenty-four days later, the patient presented in a comatose state after collapsing and was euthanized. Postmortem examination revealed coronary arteriosclerosis and myocardial infarction leading to congestive heart failure. Calcinosis cutis and myocardial necrosis were most likely complications associated with administration of corticosteroids in this dog. Important implications regarding the classification of calcinosis cutis and the use of immunosuppressive doses of corticosteroids are discussed.
authors.affiliation: Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, Saskatoon, Saskatchewan, Canada.
authors.forename: Kimberly
authors.initials: K
authors.lastname: Hsu
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Snead
authors.forename: Jennifer
authors.initials: J
authors.lastname: Davies
authors.forename: Anthony
authors.initials: A
authors.lastname: Carr
mesh_terms: D000305:Adrenal Cortex Hormones / Q000009:adverse effects* / Q000627:therapeutic use; D000308:Adrenocortical Hyperfunction / Q000139:chemically induced / Q000662:veterinary*; D000818:Animals; D002114:Calcinosis / Q000139:chemically induced / Q000662:veterinary*; D004283:Dog Diseases / Q000139:chemically induced*; D004285:Dogs; D017809:Fatal Outcome; D008297:Male; D009203:Myocardial Infarction / Q000139:chemically induced / Q000662:veterinary*; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000188:drug therapy / Q000662:veterinary*
chemical_list: D000305:Adrenal Cortex Hormones