title: Preoperative autologous blood donation and acute normovolemic hemodilution affect intraoperative blood loss during sagittal split ramus osteotomy.
abstract: BACKGROUND
  This study aimed to determine the effects of acute normovolemic hemodilution (ANH) using low-molecular-weight hydroxyethyl starch (LMW-HES) on intraoperative blood loss in patients who had received preoperative autologous blood donation (PABD) and had undergone sagittal split ramus osteotomy (SSRO).
  
  
  METHODS
  Patients who had undergone SSRO were analyzed. All 250 patients received PABD of 400-800 mL until 2 weeks before surgery. ANH was performed by withdrawing whole blood, which was replaced by the same volume of LMW-HES. ANH was performed in 197 cases for 200 mL replacement (ANH-200) and in 5 cases for 400 mL replacement (ANH-400); it was not performed in 48 cases (ANH-0).
  
  
  RESULTS
  Blood loss in ANH-200 was greater than that in ANH-0, despite no differences in hemoglobin concentrations at pre- and post-PABD, prothrombin time, activated partial thromboplastin time, fibrinogen and platelet counts between the groups before surgery. Blood loss increased as the total withdrawn blood (sum of PABD and ANH) increased.
  
  
  CONCLUSIONS
  Increased intraoperative blood loss was associated with total withdrawn blood before the operation as well as ANH.
authors.affiliation: Department of Dental Anesthesia, Kagoshima University Medical and Dental Hospital, Japan.
authors.forename: Yoko
authors.initials: Y
authors.lastname: Iwase
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kohjitani
authors.forename: Akina
authors.initials: A
authors.lastname: Tohya
authors.forename: Kazuna
authors.initials: K
authors.lastname: Sugiyama
mesh_terms: D000293:Adolescent; D000328:Adult; D001782:Blood Donors; D016063:Blood Loss, Surgical; D001804:Blood Transfusion, Autologous; D005260:Female; D006438:Hemodilution; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008297:Male; D059229:Osteotomy, Sagittal Split Ramus; D011300:Preoperative Care
chemical_list: D006454:Hemoglobins