title: Undecaprenyl diphosphate synthase, a cis-prenyltransferase synthesizing lipid carrier for bacterial cell wall biosynthesis.
abstract: A group of prenyltransferases produce linear lipids by catalyzing consecutive condensation reactions of farnesyl diphosphate (FPP) with specific numbers of isopentenyl diphosphate (IPP), a common building block of isoprenoid compounds. Depending on the stereochemistry of the double bonds formed during IPP condensation, these prenyltransferases are categorized as cis- and trans-types. Undecaprenyl diphosphate synthase (UPPS) that catalyzes chain elongation of FPP by consecutive condensation reactions with eight IPP, to form C₅₅ lipid carrier for bacterial cell wall biosynthesis, serves as a model for understanding cis-prenyltransferases. In this review, the current knowledge in UPPS kinetics, mechanisms, structures, and inhibitors is summarized.
authors.affiliation: Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan.
authors.forename: Kuo-Hsun
authors.initials: KH
authors.lastname: Teng
authors.forename: Po-Huang
authors.initials: PH
authors.lastname: Liang
mesh_terms: D019883:Alkyl and Aryl Transferases / Q000737:chemistry / Q000378:metabolism; D001419:Bacteria / Q000737:chemistry / Q000378:metabolism*; D001426:Bacterial Proteins / Q000737:chemistry / Q000378:metabolism; D002473:Cell Wall / Q000378:metabolism*; D004122:Dimethylallyltranstransferase / Q000737:chemistry / Q000378:metabolism; D045782:Hemiterpenes / Q000096:biosynthesis / Q000737:chemistry; D009943:Organophosphorus Compounds / Q000737:chemistry; D011106:Polyisoprenyl Phosphates / Q000096:biosynthesis / Q000737:chemistry; D017434:Protein Structure, Tertiary; D012717:Sesquiterpenes / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D001426:Bacterial Proteins; D045782:Hemiterpenes; D009943:Organophosphorus Compounds; D011106:Polyisoprenyl Phosphates; D012717:Sesquiterpenes; C004809:isopentenyl pyrophosphate; C004808:farnesyl pyrophosphate; D019883:Alkyl and Aryl Transferases; D004122:Dimethylallyltranstransferase; C023266:undecaprenyl pyrophosphate synthetase