title: Bioactive carbazole alkaloids from Clausena wallichii roots.
abstract: Four new carbazole alkaloids, clausenawallines C-F (1-4), along with 18 known compounds (5-22) were isolated from the roots of Clausena wallichii. Compounds 3, 9, and 22 exhibited significant antibacterial activity against methicillin-resistant Staphylococcus aureus SK1 (MRSA SK1) and Staph. aureus TISTR 1466 with MIC values in the range 4-16 μg/mL, whereas compound 4 showed the highest cytotoxicity against oral cavity cancer (KB) and small-cell lung cancer (NCI-H187) with IC(50) values of 10.2 and 4.5 μM, respectively.
authors.affiliation: Natural Products Research Laboratory, School of Science, Mae Fah Luang University, Tasud, Muang, Chiang Rai 57100, Thailand.
authors.forename: Wisanu
authors.initials: W
authors.lastname: Maneerat
authors.forename: Thunwadee
authors.initials: T
authors.lastname: Ritthiwigrom
authors.forename: Sarot
authors.initials: S
authors.lastname: Cheenpracha
authors.forename: Trinop
authors.initials: T
authors.lastname: Promgool
authors.forename: Kulsiri
authors.initials: K
authors.lastname: Yossathera
authors.forename: Suwanna
authors.initials: S
authors.lastname: Deachathai
authors.forename: Wong
authors.initials: W
authors.lastname: Phakhodee
authors.forename: Surat
authors.initials: S
authors.lastname: Laphookhieo
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification*; D002227:Carbazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D054700:Clausena / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D018517:Plant Roots / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects; D013785:Thailand
chemical_list: D000470:Alkaloids; D000900:Anti-Bacterial Agents; D000972:Antineoplastic Agents, Phytogenic; D002227:Carbazoles