title: [Pluripotent stem cells: a cell model for early cardiac development].
abstract: Mouse embryonic stem cell lines were derived three decades ago and allow the process of transgenesis and in turn the generation of transgenic mice. In the past and still nowadays, these mice as well as more primitive organisms have provided models to study the first cell decisions in the embryo. Derivation of human embryonic stem cells more than a decade ago has provided a similar cell model for human early embryonic development, an issue that could not be addressed for obvious ethical reasons which limit research on human embryos. These cells allow investigating the genetic and epigenetic mechanisms underlying the first cell decisions in the human embryo. Herein, we use cardiogenesis as an example to reveal the potential of these cells to better understand the first steps of cardiac development.
authors.affiliation: INSERM-UMR 633, Université Paris-Descartes, Sorbonne Paris Cité, 75015 Paris, France. michel.puceat@inserm.fr
authors.forename: Michel
authors.initials: M
authors.lastname: Pucéat
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D047108:Embryonic Development; D053595:Embryonic Stem Cells / Q000166:cytology; D005347:Fibroblasts / Q000166:cytology; D006321:Heart / Q000196:embryology*; D006351:Heart Valves / Q000166:cytology / Q000196:embryology; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D008955:Models, Cardiovascular; D009024:Morphogenesis; D032383:Myocytes, Cardiac / Q000166:cytology; D039904:Pluripotent Stem Cells / Q000166:cytology*; D013045:Species Specificity; D057905:Stem Cell Research