title: Bisphosphonate-related osteonecrosis of the jaw.
abstract: Bisphosphonates (BPs) have been used for the management of bone metabolic diseases. Currently their therapeutic use has increased, as also have their adverse effects, one of the most important being the bisphosphonate-related osteonecrosis of the jaw (BRONJ), a complication of difficult treatment and solution. Until now, the physiopathology of BRONJ remains unclear, and its treatment is uncertain. Although the literature provides several treatment options, there is no defined protocol. We present a review about BRONJ, focusing on its pathogenesis and its reported forms of treatment.
authors.affiliation: Faculdade de Odontologia, Universidade de São Paulo – USP.
authors.forename: Mariana Aparecida
authors.initials: MA
authors.lastname: Brozoski
authors.forename: Andreia Aparecida
authors.initials: AA
authors.lastname: Traina
authors.forename: Maria Cristina Zindel
authors.initials: MC
authors.lastname: Deboni
authors.forename: Márcia Martins
authors.initials: MM
authors.lastname: Marques
authors.forename: Maria da Graça
authors.initials: Mda G
authors.lastname: Naclério-Homem
mesh_terms: D059266:Bisphosphonate-Associated Osteonecrosis of the Jaw / Q000175:diagnosis / Q000209:etiology / Q000628:therapy; D006801:Humans