title: The -2518 A/G polymorphism in the monocyte chemoattractant protein 1 gene is associated with the risk of developing systemic lupus erythematosus in Argentinean patients: a multicenter study.
abstract: Systemic lupus erythematosus (SLE) is a systemic, autoimmune disorder. Monocyte chemoattractant protein 1 (MCP-1), a chemokine involved in the recruitment and migration of monocytes/macrophages, has been shown to be increased in the plasma of SLE patients. The aim of our study was to evaluate the possible association of the polymorphism -2518 of the MCP-1 gene with the risk of developing SLE, manifesting lupus nephritis (LN) and with other clinical features of SLE in an Argentinean population. A group of 171 SLE patients and 120 control subjects were examined. Genotypic and allelic frequencies of the MCP-1 -2518 A/G polymorphism showed significant differences between the SLE and the control groups (p=0.001 and p=0.01, respectively). However, the polymorphism showed no association with LN or with the other clinical variables studied. Our results suggest that the presence of the MCP-1 -2518 A/G polymorphism might be a risk factor for developing SLE in genetically predisposed individuals, but it does not seem to have a role in the evolution of the disease in the Argentinean population.
authors.affiliation: Laboratorio de Hemostasia y Trombosis, Hospital de Infecciosas Dr. F. J. Muñiz, Buenos Aires, Argentina. nanoaranda@hotmail.com
authors.forename: Federico
authors.initials: F
authors.lastname: Aranda
authors.forename: Silvia Perés
authors.initials: SP
authors.lastname: Wingeyer
authors.forename: Sebastián Andrés
authors.initials: SA
authors.lastname: Muñoz
authors.forename: Alberto
authors.initials: A
authors.lastname: Allievi
authors.forename: Alberto
authors.initials: A
authors.lastname: Orden
authors.forename: Rosana
authors.initials: R
authors.lastname: Trobo
authors.forename: Analía
authors.initials: A
authors.lastname: Alvarez
authors.forename: Alicia
authors.initials: A
authors.lastname: Eimon
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Barreira
authors.forename: Emilce
authors.initials: E
authors.lastname: Schneeberger
authors.forename: Judith
authors.initials: J
authors.lastname: Sarano
authors.forename: Julio
authors.initials: J
authors.lastname: Hofman
authors.forename: Gabriela
authors.initials: G
authors.lastname: de Larrañaga
mesh_terms: D000328:Adult; D001118:Argentina / Q000453:epidemiology / Q000208:ethnology; D016022:Case-Control Studies; D018932:Chemokine CCL2 / Q000097:blood / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000235:genetics*; D008181:Lupus Nephritis / Q000097:blood / Q000235:genetics; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: D018932:Chemokine CCL2