title: Modifier genetics in neuropsychiatric disease: challenges and opportunities.
abstract: A new study focuses attention on multigenic interactions influencing the risk of autism spectrum disorders.
authors.affiliation: Center for Human Genome Variation, Duke University School of Medicine, Durham, North Carolina 27708, USA.
authors.forename: Elizabeth K
authors.initials: EK
authors.lastname: Ruzzo
authors.forename: Andrea L
authors.initials: AL
authors.lastname: Pappas
authors.forename: David B
authors.initials: DB
authors.lastname: Goldstein
mesh_terms: D002648:Child; D002659:Child Development Disorders, Pervasive / Q000235:genetics* / Q000523:psychology; D004843:Epistasis, Genetic; D060045:Genes, Modifier; D058685:Genetic Pleiotropy; D020022:Genetic Predisposition to Disease; D006801:Humans; D010641:Phenotype; D012307:Risk Factors