title: Focal brain cooling terminates the faster frequency components of epileptic discharges induced by penicillin G in anesthetized rats.
abstract: OBJECTIVE
  The goal of the study was to investigate the effects of focal brain cooling on epileptic discharges (EDs) and background rhythms in the sensorimotor cortex of anesthetized rats using spectral analysis of electroencephalography (EEG).
  
  
  METHODS
  Penicillin G was administered intracortically into superficial layers of the left sensorimotor cortex and EDs were induced. Focal brain cooling was achieved using a cooling device attached to the cortical surface. The cortical surface was cooled to 25°C, 20°C and 15°C, and EEG was continuously recorded just beneath the cooling device. EEG spectral powers were determined using fast Fourier transform before and during cooling.
  
  
  RESULTS
  Penicillin G induced EDs and increased the Alpha and Beta power spectra. Cooling suppressed EDs with an effect that depended on the brain temperature. Cooling to 25°C attenuated Beta powers, cooling to 20°C attenuated Alpha and Beta powers, and cooling to 15°C suppressed spectral powers ranging from Delta to Beta bands.
  
  
  CONCLUSIONS
  These results suggest that focal brain cooling can terminate EDs in the cortex and suppress spectral powers with a temperature-dependent effect.
  
  
  CONCLUSIONS
  These findings may contribute to development of a new clinical treatment for patients with epilepsy.
authors.affiliation: Department of Systems Neuroscience, Graduate School of Medicine, Yamaguchi University, Ube, Yamaguchi 755-8505, Japan. h-kida@yamaguchi-u.ac.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kida
authors.forename: Masami
authors.initials: M
authors.lastname: Fujii
authors.forename: Takao
authors.initials: T
authors.lastname: Inoue
authors.forename: Yeting
authors.initials: Y
authors.lastname: He
authors.forename: Yuichi
authors.initials: Y
authors.lastname: Maruta
authors.forename: Sadahiro
authors.initials: S
authors.lastname: Nomura
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Taniguchi
authors.forename: Takuya
authors.initials: T
authors.lastname: Ichikawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Saito
authors.forename: Takeshi
authors.initials: T
authors.lastname: Yamakawa
authors.forename: Michiyasu
authors.initials: M
authors.lastname: Suzuki
mesh_terms: D000777:Anesthetics / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D058256:Brain Waves / Q000187:drug effects / Q000502:physiology; D004195:Disease Models, Animal; D004569:Electroencephalography; D004827:Epilepsy / Q000139:chemically induced* / Q000628:therapy*; D005583:Fourier Analysis; D007036:Hypothermia, Induced / Q000379:methods*; D008297:Male; D010400:Penicillin G / Q000009:adverse effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
chemical_list: D000777:Anesthetics; D000900:Anti-Bacterial Agents; D010400:Penicillin G