title: Phenolic constituents from the heartwood of Artocapus altilis and their tyrosinase inhibitory activity.
abstract: From the MeOH extract of the heartwood of Artocapus altilis, thirteen phenolic compounds have been isolated, namely curcumin (1), desmethoxycurcumin (2), retrodihydrochalcone (3), apigenin (4), tangeretin (5), nobiletin (6), O-methyldehydrodieugenol (7), dehydrodieugenol (8), beta-hydroxypropiovanillone (9), p-coumaric acid (10), p-hydroxybenzaldehyde (11), vanillin (12), and vanillic acid (13). This is the first report on the presence of these compounds in the heartwood of A. altilis. Compounds 1, 2, and 10 showed more potent tyrosinase inhibitory activities, with IC50 values ranging from 2.3 to 42.0 microM, than the positive control kojic acid (IC50, 44.6 microM). The most active compound, p-coumaric acid (10) (IC50, 2.3 microM), was 22 times more active in tyrosinase inhibitory activity than kojic acid.
authors.affiliation: Faculty of Chemistry, University of Science, Vietnam National University, HoChiMinh City, Vietnam.
authors.forename: Mai Ha Khoa
authors.initials: MH
authors.lastname: Nguyen
authors.forename: Hai Xuan
authors.initials: HX
authors.lastname: Nguyen
authors.forename: Mai Thanh Thi
authors.initials: MT
authors.lastname: Nguyen
authors.forename: Nhan Trung
authors.initials: NT
authors.lastname: Nguyen
mesh_terms: D015394:Molecular Structure; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D029586:Moraceae / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry* / Q000494:pharmacology*; D014934:Wood / Q000737:chemistry*
chemical_list: D010636:Phenols; D014442:Monophenol Monooxygenase