title: Synthesis, spectroscopic characterization and biological activities of N₄O₂ Schiff base ligand and its metal complexes of Co(II), Ni(II), Cu(II) and Zn(II).
abstract: The Schiff base ligand, bis(indoline-2-one)triethylenetetramine (L) obtained from condensation of triethylenetetramine and isatin was used to synthesize the complexes of type, [ML]Cl(2) [M=Co(II), Ni(II), Cu(II) and Zn(II)]. L was characterized on the basis of the results of elemental analysis, FT-IR, (1)H and (13)C NMR, mass spectroscopic studies. The stoichiometry, bonding and stereochemistries of complexes were ascertained on the basis of results of elemental analysis, magnetic susceptibility values, molar conductance and various spectroscopic studies. EPR, UV-vis and magnetic moments revealed an octahedral geometry for complexes. L and its Cu(II) and Zn(II) complexes were screened for their antibacterial activity. Analgesic activity of Cu(II) and Zn(II) complexes was also tested in rats by tail flick method. Both complexes were found to possess good antibacterial and moderate analgesic activity.
authors.affiliation: Department of Chemistry, Science College, King Saud University, Riyadh, Saudi Arabia.
authors.forename: Saud I
authors.initials: SI
authors.lastname: Al-Resayes
authors.forename: Mohammad
authors.initials: M
authors.lastname: Shakir
authors.forename: Ambreen
authors.initials: A
authors.lastname: Abbasi
authors.forename: Kr Mohammad Yusuf
authors.initials: KM
authors.lastname: Amin
authors.forename: Abdul
authors.initials: A
authors.lastname: Lateef
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D003035:Cobalt / Q000737:chemistry / Q000494:pharmacology; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D003300:Copper / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D008024:Ligands; D009532:Nickel / Q000737:chemistry / Q000494:pharmacology; D009585:Nitrogen Dioxide / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D010146:Pain / Q000188:drug therapy; D051381:Rats; D012545:Schiff Bases / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D013057:Spectrum Analysis; D015032:Zinc / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000700:Analgesics; D000900:Anti-Bacterial Agents; D056831:Coordination Complexes; D008024:Ligands; D012545:Schiff Bases; D003035:Cobalt; D003300:Copper; D009532:Nickel; D015032:Zinc; D009585:Nitrogen Dioxide