title: Labdane-type diterpenes and flavones from Dodonaea viscosa.
abstract: A new labdane diterpenoid, 2,18-dihydroxylabda-7,13(E)-dien-15-oic acid (1), together with two known labdane diterpenes (3, 4), a new flavone, 5,7-dihydroxy-3,6,4'-trimethoxy-3'-(4-hydroxy-3-methyl-but-2-enyl)flavone (2) with three known flavones (5-7) were isolated from the aerial parts of Dodonaea viscosa. Their structures were determined by extensive analysis of spectroscopic data (1D and 2D NMR, MS) and by comparison with literature data. The anti-inflammatory activity of five compounds (1-5) was evaluated with a flow cytometry TNF-α secretion assay on human THP-1 cell line.
authors.affiliation: Department of Chemistry, University of Dschang, Dschang, Cameroon.
authors.forename: Hippolyte Kamdem
authors.initials: HK
authors.lastname: Wabo
authors.forename: Philippe
authors.initials: P
authors.lastname: Chabert
authors.forename: Pierre
authors.initials: P
authors.lastname: Tane
authors.forename: Olivier
authors.initials: O
authors.lastname: Noté
authors.forename: Michel Feussi
authors.initials: MF
authors.lastname: Tala
authors.forename: Jean
authors.initials: J
authors.lastname: Peluso
authors.forename: Christian
authors.initials: C
authors.lastname: Muller
authors.forename: Haruhisa
authors.initials: H
authors.lastname: Kikuchi
authors.forename: Yoshiteru
authors.initials: Y
authors.lastname: Oshima
authors.forename: Annelise
authors.initials: A
authors.lastname: Lobstein
mesh_terms: D000893:Anti-Inflammatory Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002460:Cell Line; D006801:Humans; D047348:Hydrolyzable Tannins / Q000494:pharmacology*; D015394:Molecular Structure; D035261:Plant Components, Aerial; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology; D029631:Sapindaceae / Q000737:chemistry*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D047348:Hydrolyzable Tannins; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha; C575149:terchebulin