title: The influence of initial peritoneal transport characteristics, inflammation, and high glucose exposure on prognosis for peritoneal membrane function.
abstract: BACKGROUND
  Fast transport status, acquired with time on peritoneal dialysis (PD), is a pathology induced by peritoneal exposure to bioincompatible solutions. Fast transport has important clinical consequences and should be prevented.
  
  
  OBJECTIVE
  We analyzed the repercussions of initial peritoneal transport characteristics on the prognosis for peritoneal membrane function, and also whether the influence of peritonitis and high exposure to glucose are different according to the initial peritoneal transport characteristics or the moment when such events occur.
  
  
  METHODS
  The study included 275 peritoneal dialysis patients with at least 2 peritoneal function studies (at baseline and 1 year). Peritoneal kinetic studies were performed at baseline and annually. Those studies consist of a 4-hour dwell with glucose (1.5% during 1981 - 1990, and 2.27% during 1991 - 2002) to calculate the peritoneal mass transfer coefficients of urea and creatinine (milliliters per minute) using a previously described mathematical model.
  
  
  RESULTS
  Membrane prognosis and technique survival were independent of baseline transport characteristics. Fast transport and ultrafiltration (UF) failure are reversible conditions, provided that peritonitis and high glucose exposure are avoided during the early dialysis period. The first year on PD is a main determining factor for the membrane's future, and the mass transfer coefficient of creatinine at year 1 is the best functional predictor of future PD history. After 5 years on dialysis, permeability frequently increases, and UF decreases. Icodextrin is associated with peritoneal protection.
  
  
  CONCLUSIONS
  Peritoneal membrane prognosis is independent of baseline transport characteristics. Intrinsic fast transport and low UF are reversible conditions when peritonitis and high glucose exposure are avoided during the early dialysis period. Icodextrin helps in glucose avoidance and is associated with peritoneal protection.
authors.affiliation: IdiPAZ, Hospital Universitario La Paz, Madrid, Spain. jfernandezre@saludcastillayleon.es
authors.forename: M José
authors.initials: MJ
authors.lastname: Fernández-Reyes
authors.forename: M Auxiliadora
authors.initials: MA
authors.lastname: Bajo
authors.forename: Gloria
authors.initials: G
authors.lastname: Del Peso
authors.forename: Marta
authors.initials: M
authors.lastname: Ossorio
authors.forename: Raquel
authors.initials: R
authors.lastname: Díaz
authors.forename: Beatriz
authors.initials: B
authors.lastname: Carretero
authors.forename: Rafael
authors.initials: R
authors.lastname: Selgas
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D003404:Creatinine / Q000032:analysis; D015314:Dialysis Solutions / Q000627:therapeutic use*; D005260:Female; D005936:Glucans / Q000627:therapeutic use; D005947:Glucose / Q000627:therapeutic use; D006801:Humans; D000077607:Icodextrin; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis / Q000009:adverse effects; D010538:Peritonitis / Q000453:epidemiology; D011379:Prognosis; D016016:Proportional Hazards Models; D014462:Ultrafiltration
chemical_list: D001786:Blood Glucose; D015314:Dialysis Solutions; D005936:Glucans; D000077607:Icodextrin; D003404:Creatinine; D005947:Glucose