title: The chemistry of the polycyclic polyprenylated acylphloroglucinols.
abstract: With their fascinating biological profiles and stunningly complex molecular architectures, the polycyclic polyprenylated acylphloroglucinols (PPAPs) have long provided a fertile playing field for synthetic organic chemists. In particular, the recent advent of innovative synthetic methods and strategies together with C-C bond-forming reactions and asymmetric catalysis have revitalized this field tremendously. Consequently, PPAP targets which once seemed beyond reach have now been synthesized. This Review aims to highlight the recent achievements in the total synthesis of PPAPs, as well as notable methods developed for the construction of the bicyclo[3.3.1] core of these chemically and biologically intriguing molecules.
authors.affiliation: Chemical Synthesis Laboratory@Biopolis, Institute of Chemical and Engineering Sciences, Agency for Science, Technology and Research (A*STAR), 11 Biopolis Way, The Helios Block, no.03-08, Singapore 138667, Singapore.
authors.forename: Jean-Alexandre
authors.initials: JA
authors.lastname: Richard
authors.forename: Rebecca H
authors.initials: RH
authors.lastname: Pouwer
authors.forename: David Y-K
authors.initials: DY
authors.lastname: Chen
mesh_terms: D001688:Biological Products / Q000138:chemical synthesis / Q000737:chemistry; D002384:Catalysis; D003500:Cyclization; D010696:Phloroglucinol / Q000138:chemical synthesis / Q000737:chemistry*; D054876:Prenylation; D012643:Selenium / Q000737:chemistry
chemical_list: D001688:Biological Products; D010696:Phloroglucinol; D012643:Selenium