title: Reference ranges for thromboelastography (TEG(®) ) and traditional coagulation tests in term parturients undergoing caesarean section under spinal anaesthesia*.
abstract: There has been little published work defining 'normal' thromboelastography (TEG(®) ) values in healthy parturients, and few large studies defining reference ranges for traditional coagulation tests in this patient group. Our aim was to establish peri-operative reference ranges for TEG and for standard laboratory coagulation tests in our pregnant population. Fifty healthy term parturients presenting for elective caesarean section under spinal anaesthesia had blood samples taken pre-operatively, on arrival in the recovery room and, in a subset of 33 women, 4 h after routine thromboprophylaxis with enoxaparin 40 mg. All three samples had TEG analysis, the first and second having standard laboratory coagulation tests in addition. Reference ranges for our pregnant population were established, demonstrating a hypercoagulable state in term parturients and a significant effect of enoxaparin. The standard coagulation reference ranges were within 98% of the local non-pregnant ranges. These reference ranges provide a useful comparator for peri-operative TEG and routine coagulation analysis in term parturients.
authors.affiliation: Chelsea and Westminster Hospital, London, UK. bemacafee@doctors.org.uk
authors.forename: B
authors.initials: B
authors.lastname: Macafee
authors.forename: J P
authors.initials: JP
authors.lastname: Campbell
authors.forename: K
authors.initials: K
authors.lastname: Ashpole
authors.forename: M
authors.initials: M
authors.lastname: Cox
authors.forename: F
authors.initials: F
authors.lastname: Matthey
authors.forename: L
authors.initials: L
authors.lastname: Acton
authors.forename: S M
authors.initials: SM
authors.lastname: Yentis
mesh_terms: D000293:Adolescent; D000328:Adult; D000773:Anesthesia, Obstetrical / Q000379:methods*; D000775:Anesthesia, Spinal / Q000379:methods*; D000925:Anticoagulants / Q000494:pharmacology / Q000627:therapeutic use; D001777:Blood Coagulation / Q000187:drug effects; D001780:Blood Coagulation Tests; D002585:Cesarean Section; D017984:Enoxaparin / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods; D019990:Perioperative Care / Q000379:methods; D011183:Postoperative Complications / Q000517:prevention & control; D011247:Pregnancy; D012016:Reference Values; D013916:Thrombelastography / Q000379:methods*; D013923:Thromboembolism / Q000517:prevention & control; D055815:Young Adult
chemical_list: D000925:Anticoagulants; D017984:Enoxaparin