title: Report: Combustion Byproducts and Their Health Effects: Summary of the 10th International Congress.
abstract: The 10th International Congress on Combustion Byproducts and their Health Effects was held in Ischia, Italy, from June 17-20, 2007. It is sponsored by the US NIEHS, NSF, Coalition for Responsible Waste Incineration (CRWI), and Electric Power Research Institute (EPRI). The congress focused on: the origin, characterization, and health impacts of combustion-generated fine and ultrafine particles; emissions of mercury and dioxins, and the development/application of novel analytical/diagnostic tools. The consensus of the discussion was that particle-associated organics, metals, and persistent free radicals (PFRs) produced by combustion sources are the likely source of the observed health impacts of airborne PM rather than simple physical irritation of the particles. Ultrafine particle-induced oxidative stress is a likely progenitor of the observed health impacts, but important biological and chemical details and possible catalytic cycles remain unresolved. Other key conclusions were: (1) In urban settings, 70% of airborne fine particles are a result of combustion emissions and 50% are due to primary emissions from combustion sources, (2) In addition to soot, combustion produces one, possibly two, classes of nanoparticles with mean diameters of ~10 nm and ~1 nm. (3) The most common metrics used to describe particle toxicity, viz. surface area, sulfate concentration, total carbon, and organic carbon, cannot fully explain observed health impacts, (4) Metals contained in combustion-generated ultrafine and fine particles mediate formation of toxic air pollutants such as PCDD/F and PFRs. (5) The combination of metal-containing nanoparticles, organic carbon compounds, and PFRs can lead to a cycle generating oxidative stress in exposed organisms.
authors.forename: Barry
authors.initials: B
authors.lastname: Dellinger
authors.forename: Antonio
authors.initials: A
authors.lastname: D'Alessio
authors.forename: Andrea
authors.initials: A
authors.lastname: D'Anna
authors.forename: Anna
authors.initials: A
authors.lastname: Ciajolo
authors.forename: Brian
authors.initials: B
authors.lastname: Gullett
authors.forename: Heather
authors.initials: H
authors.lastname: Henry
authors.forename: Mel
authors.initials: M
authors.lastname: Keener
authors.forename: Joann
authors.initials: J
authors.lastname: Lighty
authors.forename: Slawomir
authors.initials: S
authors.lastname: Lomnicki
authors.forename: Donald
authors.initials: D
authors.lastname: Lucas
authors.forename: Günter
authors.initials: G
authors.lastname: Oberdörster
authors.forename: Demetrio
authors.initials: D
authors.lastname: Pitea
authors.forename: William
authors.initials: W
authors.lastname: Suk
authors.forename: Adel
authors.initials: A
authors.lastname: Sarofim
authors.forename: Kirk R
authors.initials: KR
authors.lastname: Smith
authors.forename: Tobias
authors.initials: T
authors.lastname: Stoeger
authors.forename: Paige
authors.initials: P
authors.lastname: Tolbert
authors.forename: Ron
authors.initials: R
authors.lastname: Wyzga
authors.forename: Ralf
authors.initials: R
authors.lastname: Zimmermann