title: An antagonist of GABA-B receptors potentiates activity of cortical epileptic foci.
abstract: Cortical epileptic foci elicited by local application of bicuculline methiodide represent a model of interictal epileptic activity with a transition into ictal phases. We studied a role of GABA-B receptors in this model using GABA-B receptor antagonist CGP35348 in adult rats with implanted cortical electrodes and cannula. CGP35348 (100 or 200 mg/kg i.p.) did not affect interictal discharges but it augmented ictal activity. Latency to the first ictal episode was decreased by the lower dose of CGP35348, duration of episodes was increased by the higher dose. GABA-B receptor antagonist did not influence purely cortical epileptic phenomenon but it is proconvulsant in ictal activity generated with participation of subcortical structures.
authors.affiliation: Department of Developmental Epileptology, Institute of Physiology, Academy of Sciences, Prague, Czech Republic. maresp@epilepsy.biomed.cas.cz
authors.forename: P
authors.initials: P
authors.lastname: Mareš
authors.forename: K
authors.initials: K
authors.lastname: Bernášková
authors.forename: H
authors.initials: H
authors.lastname: Kubová
mesh_terms: D000818:Animals; D001640:Bicuculline / Q000031:analogs & derivatives; D058256:Brain Waves / Q000187:drug effects*; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D004827:Epilepsy / Q000139:chemically induced* / Q000378:metabolism / Q000503:physiopathology; D058788:GABA-B Receptor Antagonists / Q000633:toxicity*; D008297:Male; D009943:Organophosphorus Compounds / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects; D018080:Receptors, GABA-B / Q000187:drug effects* / Q000378:metabolism; D013997:Time Factors
chemical_list: D058788:GABA-B Receptor Antagonists; D009943:Organophosphorus Compounds; D018080:Receptors, GABA-B; C017069:bicuculline methiodide; C066430:CGP 35348; D001640:Bicuculline