title: SLEEVEPASS: a randomized prospective multicenter study comparing laparoscopic sleeve gastrectomy and gastric bypass in the treatment of morbid obesity: preliminary results.
abstract: BACKGROUND
  The long-term efficacy of laparoscopic Roux-en-Y gastric bypass (RYGB) in the treatment of morbid obesity has been demonstrated. Laparoscopic sleeve gastrectomy (SG) as a single procedure has shown promising short-term results, but the long-term efficacy of SG has not yet been demonstrated. The aim of this study was to determine the preliminary 30-day morbidity and mortality of RYGB and SG in a prospective multicenter randomized setting.
  
  
  METHODS
  A total of 240 morbidly obese (BMI = 35-66 kg/m²) patients evaluated by a multidisciplinary team were randomized to undergo either RYGB or SG. There were 117 patients in the RYGB group and 121 in the SG group; two patients had to be excluded after randomization. Both study groups were comparable regarding age, gender, BMI, and comorbidities.
  
  
  RESULTS
  There was no 30-day mortality. The median operating time was significantly shorter in the SG group (66 min vs. 94 min, p < 0.001). All complications were recorded thoroughly. There were 7 (5.8 %) major complications following SG and 11 (9.4 %) after RYGB (p = 0.292). Nine (7.4 %) SG patients and 20 (17.1 %) RYGB patients had minor complications (p = 0.023). The overall morbidity was 13.2 % after SG and 26.5 % after RYGB (p = 0.010). There were three (2.5 %) early reoperations after SG and four (3.3 %) after RYGB (p = 0.719).
  
  
  CONCLUSIONS
  At 30-day analysis SG is associated with a shorter operating time and fewer early minor complications compared to RYGB. There were no significant differences in major complications or early reoperations. Long-term follow-up is required to determine the effect on weight loss, resolution of obesity-related comorbidities, and improvement of quality of life.
authors.affiliation: Department of Surgery, Turku University Hospital, PL 52, 20521 Turku, Finland. mika.helmio@tyks.fi
authors.forename: Mika
authors.initials: M
authors.lastname: Helmiö
authors.forename: Mikael
authors.initials: M
authors.lastname: Victorzon
authors.forename: Jari
authors.initials: J
authors.lastname: Ovaska
authors.forename: Marja
authors.initials: M
authors.lastname: Leivonen
authors.forename: Anne
authors.initials: A
authors.lastname: Juuti
authors.forename: Nabil
authors.initials: N
authors.lastname: Jaser
authors.forename: Pipsa
authors.initials: P
authors.lastname: Peromaa
authors.forename: Pekka
authors.initials: P
authors.lastname: Tolonen
authors.forename: Saija
authors.initials: S
authors.lastname: Hurme
authors.forename: Paulina
authors.initials: P
authors.lastname: Salminen
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005743:Gastrectomy / Q000379:methods*; D015390:Gastric Bypass / Q000379:methods*; D006801:Humans; D010535:Laparoscopy; D008297:Male; D008875:Middle Aged; D009767:Obesity, Morbid / Q000150:complications / Q000601:surgery*; D011446:Prospective Studies; D011788:Quality of Life; D055815:Young Adult