title: Emergence of unusual G6P[6] rotaviruses in children, Burkina Faso, 2009-2010.
abstract: To obtain more information about rotavirus (ROTAV) genotypes in Burkina Faso, we characterized 100 ROTAVs isolated from fecal samples of children with acute gastroenteritis in the capital city of Ouagadougou, during December 2009-March 2010. Of note, 13% of the ROTAV-positive samples, including those with mixed infections, were positive for the unusual G6 genotype ROTAV strain. The genotypes identified were G9P[8], G6P[6], G1P[6], G3P[6], G1P[8], and G2P[4]. G9P[8] subgroup (SG)II strains dominated during the beginning of the ROTAV season, but later in the season, other G types associated with P[6] and SGI specificity emerged. This emergence was related to a shift in the overall age of infected children; ROTAV SGII infected younger children and induced more severe symptoms. The finding of a high incidence of G6P[6] strains highlights the need for long-term surveillance of ROTAV strains in Burkina Faso, especially when ROTAV vaccination is being considered in several African countries.
authors.affiliation: Linköping University, Linköping, Sweden. johan.nordgren@liu.se
authors.forename: Johan
authors.initials: J
authors.lastname: Nordgren
authors.forename: Leon W
authors.initials: LW
authors.lastname: Nitiema
authors.forename: Sumit
authors.initials: S
authors.lastname: Sharma
authors.forename: Djeneba
authors.initials: D
authors.lastname: Ouermi
authors.forename: Alfred S
authors.initials: AS
authors.lastname: Traore
authors.forename: Jacques
authors.initials: J
authors.lastname: Simpore
authors.forename: Lennart
authors.initials: L
authors.lastname: Svensson
mesh_terms: D001483:Base Sequence; D002050:Burkina Faso / Q000453:epidemiology; D002675:Child, Preschool; D003967:Diarrhea / Q000453:epidemiology / Q000821:virology*; D005759:Gastroenteritis / Q000453:epidemiology / Q000821:virology*; D005814:Genes, Viral; D005838:Genotype; D006801:Humans; D015994:Incidence; D008957:Models, Genetic; D008969:Molecular Sequence Data; D058889:Molecular Typing / Q000592:standards; D060885:Multiplex Polymerase Chain Reaction / Q000592:standards; D010802:Phylogeny; D012015:Reference Standards; D012401:Rotavirus / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D012400:Rotavirus Infections / Q000453:epidemiology / Q000821:virology*; D017422:Sequence Analysis, DNA