title: First detection of VIM-4 metallo-β-lactamase-producing Escherichia coli in Russia.
abstract: An Escherichia coli isolate co-producing VIM-4 metallo-β-lactamase and CTX-M-15 extended spectrum β-lactamase was recovered from the urine of a patient with head trauma in Moscow, Russia. The bla(VIM-4) and bla(CTX-M-15) genes were carried, respectively, by transmissible plasmids of IncW and IncI1 groups. The nucleotide sequence of the VIM-4-encoding integron was nearly identical to that of In416, which represent a large group of structurally related integrons previously found in Enterobacteriaceae all around the Mediterranean basin. This is the first report of a metallo-β-lactamase-producing E. coli in Russia.
authors.affiliation: Institute of Antimicrobial Chemotherapy, Smolensk State Medical Academy, Smolensk, Russia.
authors.forename: O V
authors.initials: OV
authors.lastname: Shevchenko
authors.forename: D Y
authors.initials: DY
authors.lastname: Mudrak
authors.forename: E Y
authors.initials: EY
authors.lastname: Skleenova
authors.forename: V K
authors.initials: VK
authors.lastname: Kozyreva
authors.forename: E N
authors.initials: EN
authors.lastname: Ilina
authors.forename: L N
authors.initials: LN
authors.lastname: Ikryannikova
authors.forename: I A
authors.initials: IA
authors.lastname: Alexandrova
authors.forename: S V
authors.initials: SV
authors.lastname: Sidorenko
authors.forename: M V
authors.initials: MV
authors.lastname: Edelstein
mesh_terms: D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D004926:Escherichia coli / Q000201:enzymology* / Q000235:genetics / Q000302:isolation & purification*; D004927:Escherichia coli Infections / Q000382:microbiology*; D005798:Genes, Bacterial; D006801:Humans; D009031:Moscow; D010957:Plasmids; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D014552:Urinary Tract Infections / Q000382:microbiology; D014556:Urine / Q000382:microbiology; D014947:Wounds and Injuries / Q000150:complications; D001618:beta-Lactamases / Q000235:genetics* / Q000378:metabolism*
chemical_list: D004269:DNA, Bacterial; D001618:beta-Lactamases