title: Management of cutaneous T cell lymphoma: new and emerging targets and treatment options.
abstract: Cutaneous T cell lymphomas (CTCL) clinically and biologically represent a heterogeneous group of non-Hodgkin lymphomas, with mycosis fungoides and Sézary syndrome being the most common subtypes. Over the last decade, new immunological and molecular pathways have been identified that not only influence CTCL phenotype and growth, but also provide targets for therapies and prognostication. This review will focus on recent advances in the development of therapeutic agents, including bortezomib, the histone deacetylase inhibitors (vorinostat and romidepsin), and pralatrexate in CTCL.
authors.affiliation: College of Physicians and Surgeons, Columbia University, New York, NY, USA.
authors.forename: Janet Y
authors.initials: JY
authors.lastname: Li
authors.forename: Steven
authors.initials: S
authors.lastname: Horwitz
authors.forename: Alison
authors.initials: A
authors.lastname: Moskowitz
authors.forename: Patricia L
authors.initials: PL
authors.lastname: Myskowski
authors.forename: Melissa
authors.initials: M
authors.lastname: Pulitzer
authors.forename: Christiane
authors.initials: C
authors.lastname: Querfeld