title: Facial and axillary apocrine chromhidrosis.
abstract: Apocrine chromhidrosis is a rare, chronic, idiopathic disorder, characterized by the excretion of pigmented sweat. A 26-year-old woman presented with a 3-year history of dark blue secretions on bilateral malar cheeks. On examination, upon pressure on the cheeks, a dark blue fluid was expressed, which appeared to arise primarily from the follicle. The patient had not appreciated it, but on examination of her axillae, a very subtle blue coloring was observed. Histopathologic examination revealed apocrine glands in the deep reticular dermis. Bluish cytoplasmic granules were observed in the apocrine epithelium lining, which correspond to lipofuscin granules. The diagnosis of apocrine cromhidrosis was made. We began treatment with 20 percent aluminum chloride hexahydrate solution and capsaicin cream with poor tolerance. Finally, we treated with botulinum toxin type A with a successful response. We report a case of facial and axillary apocrine cromhidrosis with good response to botulinum toxin type A.
authors.affiliation: Department of Dermatology, Hospital Universitario de Móstoles, Madrid, Spain.
authors.forename: Berta
authors.initials: B
authors.lastname: Pérez Tato
authors.forename: Elena
authors.initials: E
authors.lastname: Zamora Martínez
authors.forename: Begoña
authors.initials: B
authors.lastname: Sánchez Albisua
authors.forename: Yosmar C
authors.initials: YC
authors.lastname: Pérez González
authors.forename: Isabel
authors.initials: I
authors.lastname: Polimón Olabarrieta
authors.forename: Silvia
authors.initials: S
authors.lastname: Marinero Escobedo
authors.forename: Paloma
authors.initials: P
authors.lastname: Fernández López
mesh_terms: D000328:Adult; D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000627:therapeutic use; D001050:Apocrine Glands / Q000473:pathology*; D019274:Botulinum Toxins, Type A / Q000627:therapeutic use; D002211:Capsaicin / Q000627:therapeutic use; D002610:Cheek / Q000473:pathology; D002712:Chlorides / Q000627:therapeutic use; D003879:Dermatologic Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008062:Lipofuscin / Q000032:analysis; D010859:Pigmentation Disorders / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D013542:Sweat / Q000187:drug effects; D013543:Sweat Gland Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D017607:Aluminum Compounds; D002712:Chlorides; D003879:Dermatologic Agents; D008062:Lipofuscin; D000077410:Aluminum Chloride; D019274:Botulinum Toxins, Type A; D002211:Capsaicin