title: CdS nanoparticles-enhanced chemiluminescence and determination of baicalin in pharmaceutical preparations.
abstract: CdS nanoparticles (CdS NPs) of different sizes were synthesized by the citrate reduction method. It was found that CdS NPs could enhance the chemiluminescence (CL) of the luminol-potassium ferricyanide system and baicalin could inhibit CdS NPs-enhanced luminol-potassium ferricyanide CL signals in alkaline solution. Based on this inhibition, a flow-injection CL method was established for determination of baicalin in pharmaceutical preparations and human urine samples. Under optimized conditions, the linear range for determination of baicalin was 5.0 x 10(-6) to 1.0 x 10(-3) g/L. The detection limit at a signal-to-noise ratio of 3 was 1.7 x 10(-6) g/L. CL spectra, UV-visible spectra and transmission electron microscopy (TEM) were used to investigate the CL mechanism. The method described is simple, selective and obviates the need of extensive sample pretreatment.
authors.affiliation: College of Chemistry and Chemical Engineering, Central South University, Changsha, Hunan, People's Republic of China. chenxiaolan@xtu.edu.cn
authors.forename: Xiaolan
authors.initials: X
authors.lastname: Chen
authors.forename: Xinmei
authors.initials: X
authors.lastname: Tan
authors.forename: Jianxiu
authors.initials: J
authors.lastname: Wang
mesh_terms: D019187:Cadmium Compounds / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry* / Q000652:urine; D017022:Flow Injection Analysis / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D049449:Luminescence; D008163:Luminescent Measurements / Q000295:instrumentation / Q000379:methods*; D053758:Nanoparticles / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000032:analysis*; D013440:Sulfides / Q000737:chemistry*
chemical_list: D019187:Cadmium Compounds; D005419:Flavonoids; D004364:Pharmaceutical Preparations; D013440:Sulfides; C034939:cadmium sulfide; C038044:baicalin