title: Homeopathic aggravation with Quinquagintamillesimal potencies.
abstract: BACKGROUND
  Homeopathic aggravation is the exacerbation of some symptoms or the whole pathological situation, followed by improvement of the patient's conditions.
  
  
  OBJECTIVE
  To evaluate the typology, intensity and frequency of homeopathic aggravation, especially with Quinquagintamillesimal (Q, LM) potencies and its prognostic value.
  
  
  METHODS
  The homeopathic prescription strategy evaluated consists in the administration of a single homeopathic medicine in Q dilutions, starting with 6Q, then a progressive scale of Q potencies. Patients whose symptoms could be attributed to a wrong and inappropriate prescription, according to the criteria previously described, were excluded.
  
  
  RESULTS
  Data was collected on 1108 patients consecutively visited from 3rd October 2002 to 31st December 2007, and 441 cases followed for at least 2 months (40% of total cases). 63 of these cases (14%) reported homeopathic aggravation: 7% reported 'slight', 5% 'medium', 2% 'intense' and 0.4% 'very intense' aggravation. Homeopathic aggravation was present in 21% of paediatric patients (≤ 14 years). About 50% of the cases manifested homeopathic aggravation 1 or 2 days after the prescription and for 67% of patients the symptoms lasted 1 week or less. Patients with aggravation of the original disease had significantly greater improvement than those patients showing the aggravation of other, new or different, symptoms or conditions, or no aggravation.
  
  
  CONCLUSIONS
  These data show that homeopathic aggravation with Q potencies is quite frequent in homeopathic clinical practice and seems to be associated with better treatment outcome.
authors.affiliation: Homeopathic Clinic, Local Health Unit n. 2 Lucca, Tuscany Regional Reference Centre, Italy. omeopatia@usl2.toscana.it
authors.forename: Elio
authors.initials: E
authors.lastname: Rossi
authors.forename: Paola
authors.initials: P
authors.lastname: Bartoli
authors.forename: Alba
authors.initials: A
authors.lastname: Bianchi
authors.forename: Cristina
authors.initials: C
authors.lastname: Endrizzi
authors.forename: Monica
authors.initials: M
authors.lastname: Da Frè
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D054796:Drug Dosage Calculations; D005260:Female; D006705:Homeopathy / Q000009:adverse effects*; D006801:Humans; D007558:Italy; D008297:Male; D008419:Materia Medica / Q000008:administration & dosage*; D008875:Middle Aged; D055502:Secondary Prevention; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D008419:Materia Medica