title: Analysis of KIR gene frequencies and HLA class I genotypes in prostate cancer and control group.
abstract: Prostate cancer is the second most common cancer in men, with a significant increase in incidence and mortality in men over 50 years of age. Natural killer cells (NK) are part of the innate immune system recognizing class I HLA molecules on target cells through their membrane receptors, called killer cell immunoglobulin-like receptors (KIR). The aim of our study is to evaluate the association between the KIR genes and HLA alleles in patients with prostate cancer and healthy controls. Two hundred patients with prostate cancer and 185 healthy controls were typed for HLA class I and KIR genes by PCR-SSP. When both groups were compared, no significant differences were found for HLA-C group 1 and group 2, HLA-Bw4, HLA-A3 and A11. No difference was seen either in KIR frequency between patients with prostate cancer and controls. In conclusion, our data suggest no potential role for the KIR gene system in prostate cancer.
authors.affiliation: Department of Immunology, Hospital de Clínicas, Porto Alegre, Brazil.
authors.forename: P
authors.initials: P
authors.lastname: Portela
authors.forename: L F
authors.initials: LF
authors.lastname: Jobim
authors.forename: P H
authors.initials: PH
authors.lastname: Salim
authors.forename: W J
authors.initials: WJ
authors.lastname: Koff
authors.forename: T J
authors.initials: TJ
authors.lastname: Wilson
authors.forename: M R
authors.initials: MR
authors.lastname: Jobim
authors.forename: G
authors.initials: G
authors.lastname: Schwartsmann
authors.forename: R
authors.initials: R
authors.lastname: Roesler
authors.forename: M
authors.initials: M
authors.lastname: Jobim
mesh_terms: D001938:Brazil / Q000453:epidemiology; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005787:Gene Frequency; D005805:Genes, MHC Class I; D056726:Genetic Association Studies / Q000379:methods; D005838:Genotype; D006650:Histocompatibility Testing / Q000379:methods; D006801:Humans; D007694:Killer Cells, Natural; D008024:Ligands; D008297:Male; D016133:Polymerase Chain Reaction / Q000379:methods; D011471:Prostatic Neoplasms / Q000235:genetics*; D054340:Receptors, KIR / Q000235:genetics*
chemical_list: D008024:Ligands; D054340:Receptors, KIR