title: In vitro effect of combined hybrid molecules from vitamin E analogues and betulinic acid on macrophage activity.
abstract: Macrophage activity was studied after treatment with hybrid molecules obtained by condensation of terpenic acid residues (betulinic and betulonic acids) and α-tocopherol analogues (α-tocopherol hemisuccinate and Trolox acid). As distinct from betulinic acid and α-tocopherol hemisuccinate, hybrid molecules did not exhibit cytotoxicity in relation to mouse peritoneal macrophages in the MTT test. Test substances inhibited the production of NO by mouse peritoneal macrophages. However, hybrid molecules had no effect on activity of macrophage arginase. Our results indicate that new molecules have anti-inflammatory activity. It can be hypothesized that these substances have immunomodulatory properties.
authors.affiliation: Institute of Pharmacology, Siberian Division of Russian Academy of Medical Sciences, Tomsk, Russia.
authors.forename: A N
authors.initials: AN
authors.lastname: Ivanova
authors.forename: Y P
authors.initials: YP
authors.lastname: Belsky
authors.forename: A Yu
authors.initials: AY
authors.lastname: Spivak
authors.forename: M G
authors.initials: MG
authors.lastname: Danilets
authors.forename: N V
authors.initials: NV
authors.lastname: Belska
authors.forename: R R
authors.initials: RR
authors.lastname: Chalitova
authors.forename: A A
authors.initials: AA
authors.lastname: Ligatcheva
authors.forename: E G
authors.initials: EG
authors.lastname: Uchasova
mesh_terms: D000818:Animals; D001119:Arginase / Q000378:metabolism; D002839:Chromans / Q000494:pharmacology; D005260:Female; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009569:Nitric Oxide / Q000378:metabolism; D053978:Pentacyclic Triterpenes; D014315:Triterpenes / Q000494:pharmacology*; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000494:pharmacology*; D024502:alpha-Tocopherol / Q000494:pharmacology; D000094062:Betulinic Acid
chemical_list: D002839:Chromans; D053978:Pentacyclic Triterpenes; D014315:Triterpenes; D014810:Vitamin E; D009569:Nitric Oxide; D001119:Arginase; D024502:alpha-Tocopherol; C010643:6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid; D000094062:Betulinic Acid