title: Vapor-induced phase transformations in docetaxel.
abstract: Vapor-induced transformations of docetaxel anhydrous (form D(A)) under ambient conditions have been studied using methanol, ethanol, and water as the solvent media. The online vapor-induced transformations were monitored by powder X-ray diffractometry. New solid forms (solvates/hydrates/anhydrous) of docetaxel anhydrous were obtained in stoichiometric ratios which were characterized completely using powder X-ray diffraction, differential scanning calorimeter, thermogravimetric analysis, and spectroscopic ((13)C solid-state nuclear magnetic spectroscopy, solution (1)H NMR, and Fourier transform infrared) techniques. The new forms namely methanol solvate (D(M)), ethanol solvate (D(E)), monohydrate (D(MH)), trihydrate (D(TH)), and anhydrous (D(AN-I) and D(AN-II)) were identified through structural analysis.
authors.affiliation: Analytical Development, Aptuit Laurus Pvt. Ltd., ICICI Knowledge Park, Turkapally, Shameerpet, Hyderabad, 500 078, India. kumarltatini@gmail.com
authors.forename: Lakshmi Kumar
authors.initials: LK
authors.lastname: Tatini
authors.forename: K V S R
authors.initials: KV
authors.lastname: Krishna Reddy
authors.forename: N
authors.initials: N
authors.lastname: Someswara Rao
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D018360:Crystallography, X-Ray; D000077143:Docetaxel; D000431:Ethanol / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D000432:Methanol / Q000737:chemistry; D015394:Molecular Structure; D044367:Phase Transition; D033362:Powder Diffraction; D012997:Solvents / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D043823:Taxoids / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods; D013818:Thermogravimetry; D014835:Volatilization; D014867:Water / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D012997:Solvents; D043823:Taxoids; D014867:Water; D000077143:Docetaxel; D000431:Ethanol; D000432:Methanol