title: Cardiac biomarkers and noninvasive predictors of atherosclerosis in chronic peritoneal dialysis patients.
abstract: BACKGROUND
  We investigated the relationship among serum cardiac biomarkers including N-terminal pro-brain natriuretic peptide (NT-pro-BNP), cardiac troponin T (cTnT), uric acid and high-sensitive C-reactive protein (hs-CRP) and noninvasive predictors of atherosclerosis including carotid intima-media thickness (IMT), aortic stiffness (pulse wave velocity (PWV)) and transthoracic coronary flow reserve (CFR) in peritoneal dialysis (PD) patients.
  
  
  METHODS
  37 PD patients were included in the study. We measured (1) carotid IMT, (2) PWV and augmentation index (AIx), and (3) CFR. Simultaneous measurements of serum NT-pro-BNP, cTnT, uric acid and hs-CRP were also performed. Associations among these variables were analyzed.
  
  
  RESULTS
  cTnT was significantly associated with carotid IMT (r = 0.747, p < 0.001), PWV (r = 0.431, p = 0.035) and CFR (r = -0.439, p = 0.007). In multivariate analysis, cTnT was a significant independent predictor of carotid IMT (β = 4.446, p < 0.001) and CFR (β = -2.272, p = 0.013). Patients with high cTnT levels (≥0.01 ng/ml) significantly hadhigher carotid IMT and PWV values. Only the aortic PWV significantly correlated with residual renal function (r = -0.574, p = 0.004).
  
  
  CONCLUSIONS
  Serum cTnT appeared to be a useful clinical biomarker for evaluating noninvasive predictors of atherosclerosis in chronic PD patients. Arterial stiffness as determined by PWV is also correlated with residual renal function.
authors.affiliation: Divisions of Nephrology, Department of Internal Medicine, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey. ykcaliskan@yahoo.com
authors.forename: Yasar
authors.initials: Y
authors.lastname: Caliskan
authors.forename: Abdullah
authors.initials: A
authors.lastname: Ozkok
authors.forename: Tulin
authors.initials: T
authors.lastname: Akagun
authors.forename: Nadir
authors.initials: N
authors.lastname: Alpay
authors.forename: Goksel
authors.initials: G
authors.lastname: Guz
authors.forename: Nihat
authors.initials: N
authors.lastname: Polat
authors.forename: Fatih
authors.initials: F
authors.lastname: Tufan
authors.forename: Tevfik
authors.initials: T
authors.lastname: Ecder
authors.forename: Semra
authors.initials: S
authors.lastname: Bozfakioglu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D050197:Atherosclerosis / Q000097:blood* / Q000175:diagnosis* / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood; D001783:Blood Flow Velocity; D002097:C-Reactive Protein / Q000378:metabolism; D059168:Carotid Intima-Media Thickness; D002648:Child; D002675:Child, Preschool; D003326:Coronary Circulation; D005260:Female; D006801:Humans; D007223:Infant; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D010530:Peritoneal Dialysis; D011237:Predictive Value of Tests; D011673:Pulsatile Flow; D020107:Troponin T / Q000097:blood; D014527:Uric Acid / Q000097:blood; D059289:Vascular Stiffness; D055815:Young Adult
chemical_list: D015415:Biomarkers; D010446:Peptide Fragments; D020107:Troponin T; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D014527:Uric Acid; D002097:C-Reactive Protein