title: Linear-stapled versus circular-stapled laparoscopic gastrojejunal anastomosis in morbid obesity: meta-analysis.
abstract: BACKGROUND
  The study aims to provide a pooled analysis of individual small trials comparing linear-stapled versus circular-stapled laparoscopic gastrojejunal (GJ) anastomosis in morbid obesity surgery.
  
  
  METHODS
  A systematic literature search of Medline, Embase, and Cochrane library databases was performed. Primary outcomes were GJ leak and stricture. Secondary outcomes were operative time, length of hospital stay, postoperative bleeding, wound infection, marginal ulcers, and estimated weight loss. Pooled odds ratios were calculated for categorical outcomes and weighted mean differences for continuous outcomes.
  
  
  RESULTS
  Nine trials were included comprising 9374 patients (2946 linear vs. 6428 circular). Primary outcome analysis revealed a statistically significant increase in the rate of GJ stricture associated with circular-stapled anastomosis. A significantly reduced rate of wound infection, bleeding, and operative time associated with linear stapling was also found. No significant differences appeared for the other outcomes.
  
  
  CONCLUSIONS
  This pooled analysis recommends the preferential use of the linear stapling technique over circular stapling.
authors.affiliation: UCLH Department of Weight Loss, Metabolic and Endocrine Surgery, University College London Hospital, London, UK. m.penna@nhs.net
authors.forename: Marta
authors.initials: M
authors.lastname: Penna
authors.forename: Sheraz R
authors.initials: SR
authors.lastname: Markar
authors.forename: Vishal
authors.initials: V
authors.lastname: Venkat-Raman
authors.forename: Alan
authors.initials: A
authors.lastname: Karthikesalingam
authors.forename: Majid
authors.initials: M
authors.lastname: Hashemi
mesh_terms: D000328:Adult; D002986:Clinical Trials as Topic; D005260:Female; D015390:Gastric Bypass / Q000379:methods*; D006801:Humans; D010535:Laparoscopy / Q000379:methods*; D007902:Length of Stay; D008297:Male; D009767:Obesity, Morbid / Q000601:surgery*; D011183:Postoperative Complications / Q000209:etiology; D017792:Surgical Stapling / Q000379:methods*; D016896:Treatment Outcome; D015431:Weight Loss