title: T-cell chronic lymphocytic leukemia in a double yellow-headed Amazon parrot (Amazona ochrocephala oratrix).
abstract: An adult, male double yellow-headed Amazon parrot (Amazona ochrocephala oratrix) was diagnosed with chronic lymphocytic leukemia based on results of a complete blood cell count and cytologic examination of a bone marrow aspirate. Treatment with oral chlorambucil was attempted, but no response was evident after 40 days. The bird was euthanatized, and the diagnosis of chronic lymphocytic leukemia was confirmed on gross and microscopic examination of tissues. Neoplastic lymphocytes were found in the bone marrow, liver, kidney, testes, and blood vessels. Based on CD3-positive immunocytochemical and immunohistochemical immunophenotyping, the chronic lymphocytic leukemia was determined to be of T-cell origin.
authors.affiliation: William R Pritchard Veterinary Medical Teaching Hospital, One Shields Ave, Davis, CA 95616, USA.
authors.forename: Anna
authors.initials: A
authors.lastname: Osofsky
authors.forename: Michelle G
authors.initials: MG
authors.lastname: Hawkins
authors.forename: Oded
authors.initials: O
authors.lastname: Foreman
authors.forename: Michael S
authors.initials: MS
authors.lastname: Kent
authors.forename: William
authors.initials: W
authors.lastname: Vernau
authors.forename: Linda J
authors.initials: LJ
authors.lastname: Lowenstine
mesh_terms: D046708:Amazona; D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D002699:Chlorambucil / Q000627:therapeutic use; D002908:Chronic Disease; D015458:Leukemia, T-Cell / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D008297:Male
chemical_list: D018906:Antineoplastic Agents, Alkylating; D002699:Chlorambucil