title: Effect of vitamin E supplementation on arsenic induced oxidative stress in goats.
abstract: The present study was designed to assess whether supplementation of different levels of vitamin E to long-term arsenic exposed goats affords protection against the oxidative stress caused by the metalloid. Twenty-four crossbred lactating goats were distributed randomly into four groups (control, T(1), T(2) and T(3)) of six in each. The animals in T(1), T(2) and T(3) were given 50 mg/kg DM arsenic daily, while in T(2) and T(3), vitamin E @100 IU and 150 IU/kg DM, respectively, was also supplemented additionally for the period of 12 months. Compared to control, significant (p < 0.05) decline in SOD (45 %), CAT activities of erythrocytes (63 %), plasma total Ig (22 %) and total antioxidant activity (24 %) was observed in only arsenic treated groups and vitamin E supplementation in both doses produced partial mitigation effect against SOD (23 %, 20 %) and CAT (39 %, 48 %) while complete mitigation against total Ig (16 %, 7 %) and antioxidant activity (10 %, 8 %) was found. Average lymphocyte stimulation index at the end of experiment was (p < 0.05) lower in arsenic exposed groups (1.003 ± 0.01) and significant (p < 0.05) recovery was observed in response of vitamin E supplementation at higher doses (1.138 ± 0.03). So, vitamin E is helpful in reducing the burden of arsenic induced oxidative stress and activities of antioxidant enzymes in goats.
authors.affiliation: National Dairy Research Institute, Karnal, 132001, Haryana, India. tapanndri@gmail.com
authors.forename: T K
authors.initials: TK
authors.lastname: Das
authors.forename: V
authors.initials: V
authors.lastname: Mani
authors.forename: H
authors.initials: H
authors.lastname: Kaur
authors.forename: N
authors.initials: N
authors.lastname: Kewalramani
authors.forename: S
authors.initials: S
authors.lastname: De
authors.forename: A
authors.initials: A
authors.lastname: Hossain
authors.forename: D
authors.initials: D
authors.lastname: Banerjee
authors.forename: B K
authors.initials: BK
authors.lastname: Datta
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001151:Arsenic / Q000633:toxicity*; D002374:Catalase / Q000378:metabolism; D019587:Dietary Supplements; D005260:Female; D006041:Goats; D015386:Hazardous Substances / Q000633:toxicity*; D007136:Immunoglobulins / Q000097:blood; D007774:Lactation / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects*; D013482:Superoxide Dismutase / Q000378:metabolism; D014810:Vitamin E / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D015386:Hazardous Substances; D007136:Immunoglobulins; D014810:Vitamin E; D002374:Catalase; D013482:Superoxide Dismutase; D001151:Arsenic