title: Copaiba oil-resin treatment is neuroprotective and reduces neutrophil recruitment and microglia activation after motor cortex excitotoxic injury.
abstract: The oil-resin of Copaifera reticulata Ducke is used in the Brazilian folk medicine as an anti-inflammatory and healing agent. However, there are no investigations on the possible anti-inflammatory and neuroprotective roles of copaiba oil-resin (COR) after neural disorders. We have investigated the anti-inflammatory and neuroprotective effects of COR following an acute damage to the motor cortex of adult rats. Animals were injected with the neurotoxin N-Methyl-D-Aspartate (NMDA) (n = 10) and treated with a single dose of COR (400 mg/kg, i.p.) soon after surgery (Group 1) or with two daily doses (200 mg/kg, i.p.) during 3 days (Group 2) alter injury. Control animals were treated with vehicle only. COR treatment induced tissue preservation and decreased the recruitment of neutrophils and microglial activation in the injury site compared to vehicle animals. The results suggest that COR treatment induces neuroprotection by modulating inflammatory response following an acute damage to the central nervous system.
authors.affiliation: Laboratory of Experimental Neuroprotection and Neuroregeneration, Institute of Biological Sciences, Federal University of Pará, 66075-900 Belém, PA, Brazil.
authors.forename: Adriano
authors.initials: A
authors.lastname: Guimarães-Santos
authors.forename: Diego Siqueira
authors.initials: DS
authors.lastname: Santos
authors.forename: Ijair Rogério
authors.initials: IR
authors.lastname: Santos
authors.forename: Rafael Rodrigues
authors.initials: RR
authors.lastname: Lima
authors.forename: Antonio
authors.initials: A
authors.lastname: Pereira
authors.forename: Lucinewton Silva
authors.initials: LS
authors.lastname: de Moura
authors.forename: Raul Nunes
authors.initials: RN
authors.lastname: Carvalho
authors.forename: Osmar
authors.initials: O
authors.lastname: Lameira
authors.forename: Walace
authors.initials: W
authors.lastname: Gomes-Leal