title: [Expression   and     significance    of CEACAM1 and HBx in HBV related hepatocellular carcinoma].
abstract: OBJECTIVE
  To investigate the expression and clinical significance of CEACAM1 and HBx in HBV related hepatocellular carcinoma.
  
  
  METHODS
  The expression of CEACAM1 and HBx in 81 HBV related hepatocellular carcinoma were detected by immunohistochemistry,  and the relationship with clinicopathological features was analyzed. The expression of CEACAM1 in the human normal hepatocyte cell line QZG,  HepG2 and HepG2-X were detected by Western blot.
  
  
  RESULTS
  The positive rate of CEACAM1 and HBx in 81 HBV related hepatocellular carcinoma tissues were 71.60%(58/81) and 74.07%(60/81) respectively. The expression of CEACAM1 and HBx were correlated with  portal vein invasion, nodal metastasis and TNM staging. The expression of CEACAM1 was negative correlated with HBx(r(s);=-0.310, P<0.01).  CEACAM1 protein was significantly down regulated in HepG2-X than in HepG2-PC and human normal hepatocyte cell line QZG.
  
  
  CONCLUSIONS
  The higher expression of HBx and lower expression of CEACAM1  are  correlated with invasion and metastasis of HBV related hepatocelular carcinoma,  CEACAM1 may be a  effect  molecule in HBV related hepatocarcinogenesis.
authors.affiliation: Department of Digestion, The First Affiliated Hospital of Xi'an Medical University, Xi'an 710077, China. kaigeliu@gmail.com
authors.forename: Kai-Ge
authors.initials: KG
authors.lastname: Liu
authors.forename: Gang-Zhu
authors.initials: GZ
authors.lastname: Xu
authors.forename: Yang
authors.initials: Y
authors.lastname: Yao
authors.forename: Wei
authors.initials: W
authors.lastname: Wu
authors.forename: Ya-Jun
authors.initials: YJ
authors.lastname: Li
authors.forename: Ting-Ting
authors.initials: TT
authors.lastname: Ren
authors.forename: Guang-Hua
authors.initials: GH
authors.lastname: Xu
authors.forename: Lin
authors.initials: L
authors.lastname: Ye
mesh_terms: D015703:Antigens, CD / Q000096:biosynthesis*; D015153:Blotting, Western; D006528:Carcinoma, Hepatocellular / Q000378:metabolism* / Q000473:pathology / Q000821:virology; D015815:Cell Adhesion Molecules / Q000096:biosynthesis*; D002460:Cell Line; D005260:Female; D056945:Hep G2 Cells; D006509:Hepatitis B / Q000378:metabolism* / Q000473:pathology / Q000821:virology; D006515:Hepatitis B virus / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000821:virology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D015534:Trans-Activators / Q000096:biosynthesis*; D054334:Viral Regulatory and Accessory Proteins
chemical_list: D015703:Antigens, CD; C069847:CD66 antigens; D015815:Cell Adhesion Molecules; D015534:Trans-Activators; D054334:Viral Regulatory and Accessory Proteins; C057628:hepatitis B virus X protein