title: Thymoma and solid-organ transplantation.
abstract: Solid-organ-transplant recipients are at high risk of developing cancer, including thoracic malignancies. Herein, we report on two cases of thymoma in solid-organ recipients. One case was a female kidney-transplant recipient who had a type B2, Masaoka stage IVA thymoma that was treated by extended surgical resection followed by postoperative radiation therapy. The second case was type A Masaoka II thymoma that occurred after a liver transplant. The role of EBV in the oncogenesis of thymoma is controversial. We suggest that viruses may induce neoplasms in this specific population, as observed in post-transplant lymphoproliferative disorders. However, Epstein-Barr-encoded RNA (EBER) was negative in both patients.
authors.affiliation: Pulmonology Department, Rangueil-Larrey University Hospital, Toulouse, France. nicolas.guibert@hotmail.fr
authors.forename: Nicolas
authors.initials: N
authors.lastname: Guibert
authors.forename: Laurent
authors.initials: L
authors.lastname: Brouchet
authors.forename: Isabelle
authors.initials: I
authors.lastname: Rouquette
authors.forename: Alain
authors.initials: A
authors.lastname: Didier
authors.forename: Lionel
authors.initials: L
authors.lastname: Rostaing
authors.forename: Nassim
authors.initials: N
authors.lastname: Kamar
authors.forename: Julien
authors.initials: J
authors.lastname: Mazieres
mesh_terms: D000368:Aged; D020031:Epstein-Barr Virus Infections / Q000175:diagnosis / Q000209:etiology; D005260:Female; D006801:Humans; D007668:Kidney / Q000821:virology; D016030:Kidney Transplantation / Q000009:adverse effects*; D008099:Liver / Q000821:virology; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D013945:Thymoma / Q000000981:diagnostic imaging* / Q000209:etiology / Q000628:therapy; D013953:Thymus Neoplasms / Q000000981:diagnostic imaging* / Q000209:etiology / Q000628:therapy