title: Lactate-induced IL-8 pathway in endothelial cells--letter.
abstract: Végran and colleagues proposed a model in which the lactate released from tumor cells through MCT4 would be taken up by endothelial cells via the MCT1 transporter and stimulate angiogenesis, using human umbilical vein endothelial cells (HUVECs) as model of tumor endothelial cells. By analyzing a total of 505 cases of human tumor samples immunostained for MCT1, we do not confirm plasma membrane expression of MCT1 in the endothelial cells of tumor-associated vessels.
authors.forename: Céline
authors.initials: C
authors.lastname: Pinheiro
authors.forename: Adhemar
authors.initials: A
authors.lastname: Longatto-Filho
authors.forename: Rosete
authors.initials: R
authors.lastname: Nogueira
authors.forename: Fernando
authors.initials: F
authors.lastname: Schmitt
authors.forename: Fátima
authors.initials: F
authors.lastname: Baltazar
mesh_terms: D001943:Breast Neoplasms / Q000098:blood supply*; D015179:Colorectal Neoplasms / Q000098:blood supply*; D006801:Humans; D016209:Interleukin-8 / Q000378:metabolism*; D019344:Lactic Acid / Q000493:pharmacokinetics*; D027501:Monocarboxylic Acid Transporters / Q000378:metabolism*; D016328:NF-kappa B / Q000378:metabolism*; D027981:Symporters / Q000378:metabolism*
chemical_list: D016209:Interleukin-8; D027501:Monocarboxylic Acid Transporters; D016328:NF-kappa B; D027981:Symporters; D019344:Lactic Acid