title: Nickel-mediated inter- and intramolecular reductive cross-coupling of unactivated alkyl bromides and aryl iodides at room temperature.
abstract: A nickel-mediated intermolecular reductive cross-coupling reaction of unactivated alkyl bromides and aryl iodides at room temperature has been developed and successfully extended to less explored intramolecular versions and tandem cyclization-intermolecular cross-coupling. Highly stereoselective (or stereospecific) synthesis of linear-fused perhydrofuro[2,3-b]furan (pyran) and spiroketal skeletons allows rapid access to these useful building blocks, which would be potentially valuable in the synthesis of relevant natural products. A rational explanation for the formation of contiguous stereogenic centers is given.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, PR of China.
authors.forename: Chang-Song
authors.initials: CS
authors.lastname: Yan
authors.forename: Yu
authors.initials: Y
authors.lastname: Peng
authors.forename: Xiao-Bo
authors.initials: XB
authors.lastname: Xu
authors.forename: Ya-Wen
authors.initials: YW
authors.lastname: Wang