title: Formation of supramolecular systems via directed Nucleoside-Lipid recognition.
abstract: We report the synthesis of a new series of Ketal Nucleoside Lipids (KNLs) featuring saturated hydrophobic double chains and either adenosine or uridine as nucleosides (KNL(A) and KNL(U), respectively). Physicochemical studies (differential scanning calorimetry, small angle X ray scattering, transmission electronic microscopy, atomic force microscopy, Langmuir isotherm, infrared spectroscopy) show that the KNLs form hydrogels below the main phase transition temperature (Tm), whereas fluid lamellar phases are obtained above T(m). Mixing complementary KNLs affords a new stable Combined Supramolecular Systems (CSSs) due to complementary A-U recognition. Molecular modeling calculations of the bilayers in a fluid state exhibit a merging of the bilayers partially due to base-base interactions.
authors.affiliation: Université de Bordeaux, Bordeaux F-33076, France.
authors.forename: Nada
authors.initials: N
authors.lastname: Taib
authors.forename: Ahissan
authors.initials: A
authors.lastname: Aimé
authors.forename: Louis
authors.initials: L
authors.lastname: Moreau
authors.forename: Michel
authors.initials: M
authors.lastname: Camplo
authors.forename: Said
authors.initials: S
authors.lastname: Houmadi
authors.forename: Bernard
authors.initials: B
authors.lastname: Desbat
authors.forename: Michel
authors.initials: M
authors.lastname: Laguerre
authors.forename: Mark W
authors.initials: MW
authors.lastname: Grinstaff
authors.forename: Isabelle
authors.initials: I
authors.lastname: Bestel
authors.forename: Philippe
authors.initials: P
authors.lastname: Barthélémy
mesh_terms: D008055:Lipids / Q000138:chemical synthesis* / Q000737:chemistry; D046911:Macromolecular Substances / Q000138:chemical synthesis / Q000737:chemistry; D008958:Models, Molecular; D015394:Molecular Structure; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry; D010316:Particle Size; D013499:Surface Properties
chemical_list: D008055:Lipids; D046911:Macromolecular Substances; D009705:Nucleosides