title: Bilateral Epstein-Barr virus-associated adrenal leiomyomas in a child without an established immunodeficiency.
abstract: Adrenal leiomyomas are rare, bilateral ones being rarer. Literature available on these rare tumors documents only 4 cases in children less than 12 years of age. Each case has been associated with acquired immune deficiency syndrome or some other immunodeficiency state. Here we present a rare case of large, bilateral, adrenal leiomyomas in a child with no known immunodeficiency. An 11-year-old girl with a past history of herpes zoster (1 year before the present complaints) was admitted with abdominal pain of 2 months' duration. Radiology revealed bilateral adrenal neoplasms, probably bilateral pheochromocytoma. Histology showed bilateral adrenal leiomyomas that were Epstein-Barr virus associated. We report this case to draw attention to the occurrence of a common pathologic entity at an uncommon site in a setting of no definite known immunodeficiency.
authors.affiliation: Department of Pathology, Seth G. S. Medical College, Mumbai, India. pragativk@yahoo.com
authors.forename: Pragati A
authors.initials: PA
authors.lastname: Sathe
authors.forename: Hardik U
authors.initials: HU
authors.lastname: Shah
authors.forename: Kanchan S
authors.initials: KS
authors.lastname: Kothari
authors.forename: Sarangarajan
authors.initials: S
authors.lastname: Ranganathan
authors.forename: Bhuvaneshwari M
authors.initials: BM
authors.lastname: Kandalkar
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000276:immunology / Q000473:pathology / Q000821:virology*; D000315:Adrenalectomy; D002648:Child; D003131:Combined Modality Therapy; D020031:Epstein-Barr Virus Infections / Q000276:immunology / Q000473:pathology / Q000821:virology*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007121:Immunocompetence; D007889:Leiomyoma / Q000276:immunology / Q000473:pathology / Q000821:virology*; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D005938:Glucocorticoids