title: Abdominal venous thrombosis presenting in myeloproliferative neoplasm with JAK2 V617F mutation: a case report.
abstract: BACKGROUND
  An unprovoked thombotic event in a patient is cause for further evaluation of an underlying hypercoaguable state. The investigation should include a thorough search, including checking for a variety of known inherited and acquired hypercoaguble states (protein C or S deficiency, anti-phospholipid antibodies, and anti-thrombin III deficiency) and gene mutations that predispose patients to an increased risk of clotting (for example, prothrombin gene 20210 mutation, factor V Leiden, and the JAK2 V617F mutation).
  
  
  METHODS
  We report the case of a 38-year-old Caucasian woman with spontaneous, unprovoked abdominal venous thrombosis and demonstrate how testing for the JAK2 V617F mutation was useful in unmasking an underlying hypercoaguable state.
  
  
  CONCLUSIONS
  JAK2 V617F-positive myeloproliferative neoplasm was diagnosed. This case illustrates the importance of testing for JAK2 V617F in patients presenting with Budd-Chiari syndrome, even in the absence of overt hematologic abnormalities, in order to establish a diagnosis of underlying myeloproliferative neoplasm.
authors.affiliation: MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA. npemmaraju@mdanderson.org.
authors.forename: Naveen
authors.initials: N
authors.lastname: Pemmaraju
authors.forename: James Peter
authors.initials: JP
authors.lastname: Hamilton
authors.forename: Andrew M
authors.initials: AM
authors.lastname: Cameron
authors.forename: Stephen
authors.initials: S
authors.lastname: Sisson
authors.forename: Alison R
authors.initials: AR
authors.lastname: Moliterno