title: Cardiovascular effects of treatment with taxanes.
abstract: Taxanes are cytotoxic drugs that stabilize cellular microtubules and are among the most active of the antineoplastic agents being widely used in the treatment of cancer patients. Furthermore, taxanes comprise a valuable tool in interventional cardiology. Following treatment with taxanes, in many patients, the risk of cardiovascular complications has recently been noted. This review examines the cardiac toxicity of treatment with taxanes and their use in cardiology and analyzes issues in clinical practice.
authors.affiliation: Department of Medical Oncology, School of Medicine, University of Patras, Patras, Greece. panio@upatras.gr
authors.forename: Stavros
authors.initials: S
authors.lastname: Peroukides
authors.forename: Alexandros
authors.initials: A
authors.lastname: Alexopoulos
authors.forename: Haralabos
authors.initials: H
authors.lastname: Kalofonos
authors.forename: Helen
authors.initials: H
authors.lastname: Papadaki
mesh_terms: D018943:Anthracyclines / Q000009:adverse effects; D000903:Antibiotics, Antineoplastic / Q000009:adverse effects; D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects*; D002317:Cardiovascular Agents / Q000009:adverse effects*; D002318:Cardiovascular Diseases / Q000139:chemically induced*; D004357:Drug Synergism; D006801:Humans; D018570:Risk Assessment; D012307:Risk Factors; D043823:Taxoids / Q000009:adverse effects*; D050257:Tubulin Modulators / Q000009:adverse effects*
chemical_list: D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; D000972:Antineoplastic Agents, Phytogenic; D002317:Cardiovascular Agents; D043823:Taxoids; D050257:Tubulin Modulators