title: Microfluidic generation of acoustically active nanodroplets.
abstract: A microfluidic approach for the generation of perfluorocarbon nanodroplets as the primary emulsion with diameters as small as 300-400 nm is described. The system uses a pressure-controlled delivery of all reagents and increased viscosity in the continuous phase to drive the device into an advanced tip-streaming regime, which results in generation of droplets in the sub-micrometer range. Such nanodroplets may be appropriate for emerging biomedical applications.
authors.affiliation: Curriculum of Applied Science & Engineering - Material Science, University of North Carolina, 310 Taylor Hall, CB 7575, Chapel Hill, NC 27599, USA.
authors.forename: Thomas D
authors.initials: TD
authors.lastname: Martz
authors.forename: David
authors.initials: D
authors.lastname: Bardin
authors.forename: Paul S
authors.initials: PS
authors.lastname: Sheeran
authors.forename: Abraham P
authors.initials: AP
authors.lastname: Lee
authors.forename: Paul A
authors.initials: PA
authors.lastname: Dayton
mesh_terms: D000162:Acoustics; D016503:Drug Delivery Systems; D004867:Equipment Design; D005466:Fluorocarbons / Q000737:chemistry; D005990:Glycerol / Q000737:chemistry; D008208:Lymphatic System / Q000187:drug effects; D046210:Microfluidic Analytical Techniques; D044085:Microfluidics; D008853:Microscopy / Q000379:methods; D046529:Microscopy, Electron, Transmission / Q000379:methods; D036103:Nanotechnology / Q000379:methods; D055095:Optics and Photonics / Q000379:methods; D010316:Particle Size; D011312:Pressure; D014783:Viscosity
chemical_list: D005466:Fluorocarbons; D005990:Glycerol