title: Ocular findings in a patient with virus-associated hemophagocytic syndrome.
abstract: OBJECTIVE
  To describe a case of virus-associated hemophagocytic syndrome with ocular changes resembling Vogt-Koyanagi-Harada disease prior to the systemic changes.
  
  
  METHODS
  A 51-year-old man presented with a sudden decline in vision. The patient was examined by fluorescein angiography, bone marrow biopsy, abdominal ultrasound, ocular examinations, and laboratory examinations.
  
  
  RESULTS
  Fluorescein angiography revealed uveitis resembling Vogt-Koyanagi-Harada disease. Bone marrow biopsy specimen demonstrated histiocytic hyperplasia and some hemophagocytes. Abdominal ultrasound findings indicated hepato-splenomegaly. And ocular examinations revealed hematocytopenia and hypoproteinemia.
  
  
  CONCLUSIONS
  The ocular changes resembling Vogt-Koyanagi-Harada disease observed in this study could be a kind of manifestation of virus-associated hemophagocytic syndrome in retina.
authors.forename: Huiping
authors.initials: H
authors.lastname: Yao
authors.forename: Yan
authors.initials: Y
authors.lastname: Liu
authors.forename: Weizu
authors.initials: W
authors.lastname: Ding
authors.forename: Yudong
authors.initials: Y
authors.lastname: Xu
authors.forename: Yu
authors.initials: Y
authors.lastname: Cheng
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D003586:Cytomegalovirus Infections / Q000175:diagnosis / Q000188:drug therapy; D003907:Dexamethasone / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D017809:Fatal Outcome; D005451:Fluorescein Angiography; D015774:Ganciclovir / Q000627:therapeutic use; D006529:Hepatomegaly / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology; D006801:Humans; D051359:Lymphohistiocytosis, Hemophagocytic / Q000175:diagnosis* / Q000188:drug therapy / Q000821:virology; D008297:Male; D008875:Middle Aged; D015242:Ofloxacin / Q000627:therapeutic use; D013163:Splenomegaly / Q000175:diagnosis / Q000188:drug therapy / Q000821:virology; D014463:Ultrasonography; D014607:Uveomeningoencephalitic Syndrome / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000821:virology; D014792:Visual Acuity / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D003907:Dexamethasone; D015242:Ofloxacin; D015774:Ganciclovir