title: Effect of small for gestational age on hemodynamic parameters in the neonatal period.
abstract: OBJECTIVE
  The time course over which hypertension develops in children with a history of growth restriction has not been fully elucidated. The purpose of this study was to determine whether commonly obtained hemodynamic parameters were different between small for gestational age (SGA) and appropriate for gestational age (AGA) neonates.
  
  
  METHODS
  This was a retrospective case-control study matching 24 SGA neonates in a 1:2 fashion with 48 AGA neonates delivered during the same gestational week. Hemodynamic parameters were evaluated during the first week of life and the week prior to discharge.
  
  
  RESULTS
  There were no differences in blood pressure (BP) parameters during the first week of life. Compared to AGA controls, SGA neonates had a significantly lower heart rate (HR) at birth (148.2 ± 19.2 vs. 159.2 ± 17.1, p < 0.001), and a greater need for vasopressor support (OR 5.66; 95% CI 2.28, 14.04). The SGA neonates had a lower systolic BP during the week prior to discharge (68.3 ± 1.2 vs. 73.5 ± 1.2 mmHg, p < 0.001).
  
  
  CONCLUSIONS
  SGA newborns had a lower HR at birth and greater need for vasopressor support during the first week of life despite similar BP parameters. SGA newborns had a lower systolic BP prior to discharge. Further studies are needed to understand the progression to adult hypertension.
authors.affiliation: Department of Obstetrics and Gynecology, Department of Pediatrics, University of Colorado Denver, Aurora, Colorado, USA. torri.metz@hsc.utah.edu
authors.forename: Torri D
authors.initials: TD
authors.lastname: Metz
authors.forename: Anne M
authors.initials: AM
authors.lastname: Lynch
authors.forename: Pamela
authors.initials: P
authors.lastname: Wolfe
authors.forename: James S
authors.initials: JS
authors.lastname: Barry
authors.forename: Henry L
authors.initials: HL
authors.lastname: Galan
mesh_terms: D001794:Blood Pressure; D016022:Case-Control Studies; D005260:Female; D005317:Fetal Growth Retardation / Q000503:physiopathology; D006339:Heart Rate; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007236:Infant, Small for Gestational Age / Q000502:physiology*; D008297:Male; D012189:Retrospective Studies