title: Inherited genetic variation and overall survival following follicular lymphoma.
abstract: Follicular lymphoma (FL) has variable progression and survival, and improved identification of patients at high risk for progression would aid in identifying patients most likely to benefit from alternative therapy.In a sample of 244 FL cases identified during a population-based case-control study of non-Hodgkin lymphoma (NHL), we examined 6,679 tag SNPs in 488 gene regions for associations with overall FL survival. Over a median follow-up of 89 months with 65 deaths in this preliminary study, we identified 5 gene regions (BMP7, GALNT12,DUSP2, GADD45B, and ADAM17) that were associated with overall survival from FL. Results did not meet the criteria for statistical significance after adjustment for multiple hypothesis testing. These results,which support a role for host factors in determining the variable progression of FL, serve as an initial examination that can inform future studies of genetic variation and FL survival. However, they require replication in independent populations, as well as assessment in rituximab-treated patients.
authors.affiliation: Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Rockville, Maryland, USA. gibsontm@mail.nih.gov
authors.forename: Todd M
authors.initials: TM
authors.lastname: Gibson
authors.forename: Sophia S
authors.initials: SS
authors.lastname: Wang
authors.forename: James R
authors.initials: JR
authors.lastname: Cerhan
authors.forename: Matthew J
authors.initials: MJ
authors.lastname: Maurer
authors.forename: Patricia
authors.initials: P
authors.lastname: Hartge
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Habermann
authors.forename: Scott
authors.initials: S
authors.lastname: Davis
authors.forename: Wendy
authors.initials: W
authors.lastname: Cozen
authors.forename: Charles F
authors.initials: CF
authors.lastname: Lynch
authors.forename: Richard K
authors.initials: RK
authors.lastname: Severson
authors.forename: Nathaniel
authors.initials: N
authors.lastname: Rothman
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Chanock
authors.forename: Lindsay M
authors.initials: LM
authors.lastname: Morton
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D056726:Genetic Association Studies; D014644:Genetic Variation; D006801:Humans; D008224:Lymphoma, Follicular / Q000097:blood / Q000175:diagnosis* / Q000235:genetics* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D018426:SEER Program; D016019:Survival Analysis; D014481:United States / Q000453:epidemiology; D055815:Young Adult