title: Tellurium-nanowire-coated glassy carbon electrodes for selective and sensitive detection of dopamine.
abstract: Tellurium-nanowire-coated glassy carbon electrodes (TNGCEs) have been fabricated and employed for selective and sensitive detection of dopamine (DA). TNGCEs were prepared by direct deposition of tellurium nanowires, 600 ± 150 nm in length and 16 ± 3 nm in diameter, onto glassy carbon electrodes, which were further coated with Nafion to improve their selectivity and stability. Compared to the GCE, the TNGCE is more electroactive (by approximately 1.9-fold) for DA, and its selectivity toward DA over ascorbic acid (AA) and uric acid (UA) is also greater. By applying differential pulse voltammetry, at a signal-to-noise ratio of 3, the TNGCE provides a limit of detection of 1 nM for DA in the presence of 0.5mM AA and UA. Linearity (R(2)=0.9955) of the oxidation current at 0.19 V against the concentration of DA is found over the range 5 nM-1 μM. TNGCEs have been applied to determine the concentration of dopamine to be 0.59 ± 0.07 μM in PC12 cells.
authors.affiliation: Department of Chemistry, National Taiwan University, Taipei, Taiwan.
authors.forename: Hsiang-Yu
authors.initials: HY
authors.lastname: Tsai
authors.affiliation: Department of Chemistry, National Taiwan University, Taipei, Taiwan.
authors.forename: Zong-Hong
authors.initials: ZH
authors.lastname: Lin
authors.affiliation: Department of Chemistry, National Taiwan University, Taipei, Taiwan. Electronic address: changht@ntu.edu.tw.
authors.forename: Huan-Tsung
authors.initials: HT
authors.lastname: Chang
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000032:analysis; D015374:Biosensing Techniques / Q000379:methods* / Q000706:statistics & numerical data; D002244:Carbon; D004298:Dopamine / Q000032:analysis* / Q000378:metabolism; D055664:Electrochemical Techniques; D005465:Fluorocarbon Polymers; D005898:Glass; D057230:Limit of Detection; D053768:Metal Nanoparticles; D053770:Nanowires; D016716:PC12 Cells; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D012680:Sensitivity and Specificity; D013691:Tellurium; D014527:Uric Acid / Q000032:analysis
chemical_list: D005465:Fluorocarbon Polymers; D014527:Uric Acid; C040402:perfluorosulfonic acid; D002244:Carbon; D013691:Tellurium; D001205:Ascorbic Acid; D011188:Potassium; D004298:Dopamine