title: Control of sleep by cyclin A and its regulator.
abstract: How and why the brain reversibly switches from a waking to a sleep state remain among the most intriguing questions in biology. We show that cyclin A (CycA) and regulator of cyclin A1, essential cell cycle factors, function in postmitotic neurons to promote sleep in Drosophila melanogaster. Reducing the abundance of CycA in neurons delayed the wake-sleep transition, caused multiple arousals from sleep, and reduced the homeostatic response to sleep deprivation. CycA is expressed in ~40 to 50 neurons in the adult brain, most of which are intermingled with circadian clock neurons, suggesting functional interactions among neurons controlling sleep and circadian behavior.
authors.affiliation: Laboratory of Genetics, The Rockefeller University, New York, NY 10065, USA.
authors.forename: Dragana
authors.initials: D
authors.lastname: Rogulja
authors.forename: Michael W
authors.initials: MW
authors.lastname: Young
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology / Q000378:metabolism; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism*; D057906:Circadian Clocks; D019925:Cyclin A / Q000235:genetics / Q000378:metabolism*; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000235:genetics / Q000502:physiology*; D005260:Female; D017344:Genes, Insect; D006706:Homeostasis; D008297:Male; D009474:Neurons / Q000378:metabolism*; D009479:Neuropeptides / Q000235:genetics / Q000378:metabolism; D056950:Period Circadian Proteins / Q000235:genetics / Q000378:metabolism; D010641:Phenotype; D034622:RNA Interference; D012890:Sleep / Q000502:physiology*; D012892:Sleep Deprivation
chemical_list: D018797:Cell Cycle Proteins; D019925:Cyclin A; D029721:Drosophila Proteins; D009479:Neuropeptides; C539040:PER protein, Drosophila; D056950:Period Circadian Proteins; C491136:Rca1 protein, Drosophila; C113883:pdf protein, Drosophila