title: Glycidipine, a promising hypotensive and cardioprotective agent.
abstract: Toxicological pharmacological study of the molecular complex of nifedipine and glycyrrhizic acid 1:10 (glycidipine) obtained using mechanochemical technique was carried out. High hypotensive and cardioprotective effects of the agent were demonstrated. Chronic administration (45 days) produced no toxic effects in vital organs and systems of Wistar rats and ISIAH rats.
authors.affiliation: N. N. Vorozhtsov Institute of the Organic Chemistry, Russian Academy of Sciences, Novosibirsk, Russia.
authors.forename: T G
authors.initials: TG
authors.lastname: Tolstikova
authors.forename: M V
authors.initials: MV
authors.lastname: Khvostov
authors.forename: A O
authors.initials: AO
authors.lastname: Bryzgalov
authors.forename: I F
authors.initials: IF
authors.lastname: Belenichev
authors.forename: S V
authors.initials: SV
authors.lastname: Pavlov
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology; D000959:Antihypertensive Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000633:toxicity; D002316:Cardiotonic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000633:toxicity; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D004734:Energy Metabolism / Q000187:drug effects; D005260:Female; D019695:Glycyrrhizic Acid / Q000008:administration & dosage* / Q000737:chemistry / Q000633:toxicity; D006973:Hypertension / Q000188:drug therapy; D008297:Male; D017202:Myocardial Ischemia / Q000139:chemically induced / Q000188:drug therapy; D009543:Nifedipine / Q000008:administration & dosage* / Q000737:chemistry / Q000633:toxicity; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012995:Solubility; D014700:Verapamil / Q000494:pharmacology
chemical_list: D000889:Anti-Arrhythmia Agents; D000959:Antihypertensive Agents; D002316:Cardiotonic Agents; D004338:Drug Combinations; C573826:glycidipine; D019695:Glycyrrhizic Acid; D014700:Verapamil; D009543:Nifedipine