title: The genetic code and its optimization for kinetic energy conservation in polypeptide chains.
abstract: Why is the genetic code the way it is? Concepts from fields as diverse as molecular evolution, classical chemistry, biochemistry and metabolism have been used to define selection pressures most likely to be involved in the shaping of the genetic code. Here minimization of kinetic energy disturbances during protein evolution by mutation allows an optimization of the genetic code to be highlighted. The quadratic forms corresponding to the kinetic energy term are considered over the field of rational numbers. Arguments are given to support the introduction of notions from basic number theory within this context. The observations found to be consistent with this minimization are statistically significant. The genetic code may well have been optimized according to energetic criteria so as to improve folding and dynamic properties of polypeptide chains.
authors.affiliation: Analyse algébrique, Institut de Mathématique de Jussieu, Université Pierre et Marie Curie, Paris VI, France. aguillou@math.jussieu.fr
authors.forename: Antonin
authors.initials: A
authors.lastname: Guilloux
authors.forename: Jean-Luc
authors.initials: JL
authors.lastname: Jestin
mesh_terms: D005815:Genetic Code; D007700:Kinetics; D010455:Peptides / Q000737:chemistry* / Q000235:genetics
chemical_list: D010455:Peptides