title: B-cell activation induced microRNA-21 is elevated in circulating B cells preceding the diagnosis of AIDS-related non-Hodgkin lymphomas.
abstract: We show that microRNA-21 is significantly elevated in peripheral B cells of HIV-infected individuals who go on to develop AIDS-related non-Hodgkin lymphoma (n=13, <3 years prior to diagnosis) when compared with HIV-negative (n=18) or HIV-positive controls (n=21) (P<0.01). Moreover, miR-21 is overexpressed in activated B cells and can be induced by interleukin 4 alone, or with CD40 or immunoglobulin M co-stimulation, and lipopolysaccharides, suggesting that miR-21 may help maintain B-cell hyperactivation, contributing to lymphomagenesis.
authors.affiliation: Department of Obstetrics & Gynecology, David Geffen School of Medicine at UCLA, University of California Los Angeles, Los Angeles, California 90095-7365, USA.
authors.forename: Dharma R
authors.initials: DR
authors.lastname: Thapa
authors.forename: Kishor
authors.initials: K
authors.lastname: Bhatia
authors.forename: Jay H
authors.initials: JH
authors.lastname: Bream
authors.forename: Gypsyamber
authors.initials: G
authors.lastname: DʼSouza
authors.forename: Charles R
authors.initials: CR
authors.lastname: Rinaldo
authors.forename: Steven
authors.initials: S
authors.lastname: Wolinsky
authors.forename: Roger
authors.initials: R
authors.lastname: Detels
authors.forename: Otoniel
authors.initials: O
authors.lastname: Martínez-Maza
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology*; D014408:Biomarkers, Tumor; D019013:CD40 Antigens / Q000502:physiology; D016022:Case-Control Studies; D015658:HIV Infections / Q000276:immunology*; D006679:HIV Seropositivity; D006801:Humans; D007075:Immunoglobulin M / Q000502:physiology; D015847:Interleukin-4 / Q000502:physiology; D008070:Lipopolysaccharides / Q000502:physiology; D016483:Lymphoma, AIDS-Related / Q000276:immunology*; D008297:Male; D035683:MicroRNAs / Q000378:metabolism*; D014066:Palatine Tonsil / Q000276:immunology; D011446:Prospective Studies
chemical_list: D014408:Biomarkers, Tumor; D019013:CD40 Antigens; D007075:Immunoglobulin M; D008070:Lipopolysaccharides; D035683:MicroRNAs; D015847:Interleukin-4