title: An ORS-ICP-MS method for monitoring trace levels of cobalt and chromium in whole blood samples from hip arthroplasty patients with metal-on-metal prostheses.
abstract: OBJECTIVE
  To develop a rapid and reliable method, using an octopole reaction system (ORS) ICP-MS, capable of monitoring trace levels of Co and Cr in whole blood samples from hip arthroplasty patients with metal-on-metal prostheses.
  
  
  METHODS
  Whole blood is diluted 10-fold with an alkaline diluent and analyzed using an Agilent 7500 CE ORS-ICP-MS.
  
  
  RESULTS
  Limit of quantification of 0.03 μg/L Co and 0.20 μg/L Cr in patient samples. <6% covariance obtained for quality control materials analyzed over 10 runs.
  
  
  CONCLUSIONS
  This method is capable of monitoring trace levels of Co and Cr in diluted whole blood samples with a vial to vial run time of approximately 2 min. Results are comparable to those obtained using high resolution (HR) ICP-MS with sample digestion.
authors.affiliation: Alberta Centre for Toxicology, University of Calgary, Calgary, AB, Canada.
authors.forename: K L
authors.initials: KL
authors.lastname: Pei
authors.forename: D W
authors.initials: DW
authors.lastname: Kinniburgh
authors.forename: L
authors.initials: L
authors.lastname: Butlin
authors.forename: P
authors.initials: P
authors.lastname: Faris
authors.forename: D
authors.initials: D
authors.lastname: Lee
authors.forename: D A
authors.initials: DA
authors.lastname: Marshall
authors.forename: M C
authors.initials: MC
authors.lastname: Oliver
authors.forename: R
authors.initials: R
authors.lastname: Parker
authors.forename: J N
authors.initials: JN
authors.lastname: Powell
authors.forename: P
authors.initials: P
authors.lastname: Railton
authors.forename: J
authors.initials: J
authors.lastname: Smith
mesh_terms: D000497:Alloys / Q000737:chemistry; D019643:Arthroplasty, Replacement / Q000379:methods*; D002857:Chromium / Q000097:blood* / Q000737:chemistry; D003035:Cobalt / Q000097:blood* / Q000737:chemistry; D006622:Hip Prosthesis; D006801:Humans; D015203:Reproducibility of Results; D013057:Spectrum Analysis / Q000295:instrumentation / Q000379:methods*; D014131:Trace Elements / Q000097:blood
chemical_list: D000497:Alloys; D014131:Trace Elements; D002857:Chromium; D003035:Cobalt