title: Biologically active C-alkylated flavonoids from Dodonaea viscosa.
abstract: A new C-alkylated flavonoid (5,7-dihydroxy-3'-(4″-acetoxy-3″-methylbutyl)-3,6,4'-trimethoxyflavone (1), along with two known C-alkylated flavonoids (5,7-dihydroxy-3'-(3-hydroxymethylbutyl)-3,6,4'-trimethoxyflavone (2), 5,7,4'-trihydroxy-3'-(3-hyroxymethylbutyl)-3,6-dimethoxyflavone (3) and two new source C-alkylated flavonoids (5,7-dihydroxy-3'-(2-hydroxy-3-methyl-3-butenyl)-3,6,4'-trimethoxyflavone (4), 5,7,4'-trihydroxy-3,6-dimethoxy-3'-isoprenyl-flavone (5) were isolated from the aerial parts of Dodonaea viscosa. The structures of all compounds were established on the basis of 1D and 2D NMR spectroscopy and mass spectrometry. The isolated compounds were evaluated for their inhibitory effect on urease and α-chymotrypsin enzyme. All the compounds (1-5) exhibited mild inhibition against urease but remained recessive in case of α-chymotrypsin.
authors.affiliation: Department of Chemistry, University of Karachi, Karachi 75270, Pakistan.
authors.forename: Akhtar
authors.initials: A
authors.lastname: Muhammad
authors.forename: Itrat
authors.initials: I
authors.lastname: Anis
authors.forename: Ajmal
authors.initials: A
authors.lastname: Khan
authors.forename: Bishnu P
authors.initials: BP
authors.lastname: Marasini
authors.forename: Muhammad Iqbal
authors.initials: MI
authors.lastname: Choudhary
authors.forename: Muhammad Raza
authors.initials: MR
authors.lastname: Shah
mesh_terms: D000478:Alkylation; D002918:Chymotrypsin / Q000037:antagonists & inhibitors; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D035261:Plant Components, Aerial; D029631:Sapindaceae / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D014510:Urease / Q000037:antagonists & inhibitors
chemical_list: D004791:Enzyme Inhibitors; D005419:Flavonoids; D002918:Chymotrypsin; C117608:alpha-chymotrypsin; D014510:Urease