title: Association study of early-immediate genes in childhood-onset mood disorders and suicide attempt.
abstract: Childhood-onset mood disorders (COMD) are serious affective disorders with deleterious developmental sequelae including interpersonal dysfunction, psychotic symptoms and suicidal behavior. The current study examines 10 markers from two early-immediate genes for association with COMD and suicide attempt (SA) - HOMER1 and human neuronal pentraxin II (NPTX2). We examined individuals diagnosed with COMD versus matched controls, as well as individuals with COMD and a history of at least one lifetime SA versus COMD participants with no history of SA. No significant genotypic association was noted between any of the single nucleotide polymorphisms (SNPs) and COMD. Our sample yielded a nominally significant allelic association between the HOMER1 rs7713917 SNP and COMD. We report significant genotype associations between HOMER1 rs2290639 and SA , and between NPTX2 markers rs705315 and rs1681248 and SA, findings that remained statistically significant after multiple test correction. A three-way interaction was observed among HOMER1 rs4704560, rs2290639 and NPTX2 rs705318. The associations we describe for HOMER1 and NPTX2 with SA should be considered preliminary until replicated.
authors.affiliation: Centre for Addiction and Mental Health, University of Toronto, Toronto, ON, Canada. john_strauss@camh.net
authors.forename: John
authors.initials: J
authors.lastname: Strauss
authors.forename: Stuart
authors.initials: S
authors.lastname: McGregor
authors.forename: Natalie
authors.initials: N
authors.lastname: Freeman
authors.forename: Arun
authors.initials: A
authors.lastname: Tiwari
authors.forename: Charles J
authors.initials: CJ
authors.lastname: George
authors.forename: Maria
authors.initials: M
authors.lastname: Kovacs
authors.forename: James L
authors.initials: JL
authors.lastname: Kennedy
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D016009:Chi-Square Distribution; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D000072233:Homer Scaffolding Proteins; D006801:Humans; D008297:Male; D019964:Mood Disorders / Q000235:genetics* / Q000523:psychology; D009419:Nerve Tissue Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D013406:Suicide, Attempted / Q000523:psychology*; D055815:Young Adult; D000099153:Pentraxins
chemical_list: D002097:C-Reactive Protein; D002352:Carrier Proteins; D000072233:Homer Scaffolding Proteins; D009419:Nerve Tissue Proteins; D000099153:Pentraxins; C000606614:HOMER1 protein, human