title: Mutagenic effect of gold nanoparticles in the micronucleus assay.
abstract: Mutagenic activity of gold nanoparticles of different sizes were studied by micronucleus assay. Karyological analysis was performed and the count of micronucleoli in interphase bone marrow polychromatic erythrocytes in white outbred rats was determined. The animals orally received gold nanoparticles 16 and 55 nm in diameter and gold nanoshells 160 nm in diameter once a day for 7 days in a dose of 0.25 mg gold/kg. To ensure stability and biocompatibility, the surface of nanoparticles was functionalized with polyethylene glycol molecules. There were no significant differences in the number of micronucleoli in comparison with the control group, which suggests that gold nanoparticles of the specified size administered orally in the specified doses do not exhibit mutagenic activity.
authors.affiliation: V. I. Razumovsky Saratov State Medical University, Saratov, Russia.
authors.forename: D S
authors.initials: DS
authors.lastname: Jumagazieva
authors.forename: G N
authors.initials: GN
authors.lastname: Maslyakova
authors.forename: L V
authors.initials: LV
authors.lastname: Suleymanova
authors.forename: A B
authors.initials: AB
authors.lastname: Bucharskaya
authors.forename: S S
authors.initials: SS
authors.lastname: Firsova
authors.forename: B N
authors.initials: BN
authors.lastname: Khlebtsov
authors.forename: G S
authors.initials: GS
authors.lastname: Terentyuk
authors.forename: S M
authors.initials: SM
authors.lastname: Kong
authors.forename: N G
authors.initials: NG
authors.lastname: Khlebtsov
mesh_terms: D000818:Animals; D006046:Gold / Q000737:chemistry*; D008297:Male; D053768:Metal Nanoparticles / Q000009:adverse effects* / Q000737:chemistry*; D015162:Micronucleus Tests / Q000379:methods*; D009153:Mutagens; D051381:Rats
chemical_list: D009153:Mutagens; D006046:Gold