title: Fc receptor like 3 in Chinese patients of Han nationality with Guillain-Barré syndrome.
abstract: Fc receptor like 3 gene (FcRL3) has been associated with some autoimmune diseases. Here, its role in Guillain-Barré syndrome (GBS) was evaluated by studying nine FcRL3 gene SNPs in a Chinese cohort of GBS patients. The frequencies of FcRL3-3-169C, FcRL3-6 intron3A, and FcRL3-8 exon15G alleles were significantly increased in GBS patients compared with healthy controls. The frequency of FcRL3-1→9 CCTGGAGAA haplotype was significantly increased, and the frequencies of FcRL3-1→9 CCTACAAAA,CCCACGAAA, and CCTGCGGAA haplotypes were significantly decreased compared with healthy controls. These results suggest that FcRL3 is associated with GBS incidence.
authors.affiliation: Department of Neurology, the First Affiliated Hospital of Bengbu Medical College, Changhuai Road 287, Bengbu, Anhui 233004, China. sangdq@sina.com
authors.forename: Daoqian
authors.initials: D
authors.lastname: Sang
authors.forename: Qiming
authors.initials: Q
authors.lastname: Chen
authors.forename: Xiaolin
authors.initials: X
authors.lastname: Liu
authors.forename: Hongdang
authors.initials: H
authors.lastname: Qu
authors.forename: Daoxiang
authors.initials: D
authors.lastname: Wei
authors.forename: Liang
authors.initials: L
authors.lastname: Yin
authors.forename: Lina
authors.initials: L
authors.lastname: Zhang
mesh_terms: D044466:Asian People / Q000208:ethnology / Q000235:genetics; D015536:Down-Regulation / Q000235:genetics / Q000276:immunology; D005787:Gene Frequency; D020275:Guillain-Barre Syndrome / Q000235:genetics* / Q000276:immunology* / Q000378:metabolism; D006239:Haplotypes; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D011971:Receptors, Immunologic / Q000235:genetics*; D015854:Up-Regulation / Q000235:genetics / Q000276:immunology
chemical_list: C457775:FCRL3 protein, human; D011971:Receptors, Immunologic