title: Correlations between serum inflammation factors and left ventricular remodeling in acute ST segment elevation myocardial infarction.
abstract: OBJECTIVE
  To investigate the changes and correlations of the serum inflammation factors levels and left ventricular (LV) structure and function in patients with acute ST segment elevation myocardial infarction (STEMI).
  
  
  METHODS
  A prospective study was performed on 70 STEMI patients and 70 control subjects. Serum levels of interleukin-6 (IL-6), soluble CD40 ligand (sCD40L), metalloproteinase- 9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) were measured by sandwich enzyme-linked immunosorbent assay (ELISA), and cardiac structure and function were assessed by echocardiography at admission and 3-year follow-up.
  
  
  RESULTS
  We found that the levels of serum IL-6, sCD40L and MMP-9 increased steadily among control subjects, remote myocardial infarction and acute STEMI patients, and the level of TIMP-1 elevated remarkly at 3-year follow-up visit in STEMI. The admission level of serum MMP-9 positively correlated with LV end-diastolic and end-diastole volume (r=0.294, p=0.022; r=0.269, p=0.036, respectively), and TIMP-1 positively correlated with E/A ratio (r=0.278, p=0.044) at 3-year follow-up.
  
  
  CONCLUSIONS
  The study indicates that admission levels of serum MMP-9 and TIMP-1 closely correlated with left ventricular structure and function, which may be involved in the process of post-infarction remodeling of myocardium.
authors.affiliation: Department of Cardiology, Xuanwu Hospital, Capital Medical University, NO 45 Changchun Ave, Xuanwu district, Beijing 100053, PR China.
authors.forename: Jing
authors.initials: J
authors.lastname: Tan
authors.forename: Qi
authors.initials: Q
authors.lastname: Hua
mesh_terms: D000368:Aged; D023201:CD40 Ligand / Q000097:blood; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000503:physiopathology*; D011446:Prospective Studies; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000097:blood; D020257:Ventricular Remodeling / Q000502:physiology*
chemical_list: D015850:Interleukin-6; D019715:Tissue Inhibitor of Metalloproteinase-1; D023201:CD40 Ligand; D020780:Matrix Metalloproteinase 9