title: Rapid and Selective Crystallization of Acetaminophen using Metal-Assisted and Microwave-Accelerated Evaporative Crystallization.
abstract: In this paper, we demonstrate the application of Metal-Assisted and Microwave-Accelerated Evaporative Crystallization (MA-MAEC) technique to rapid and selective crystallization of a small drug compound. i.e. acetaminophen. Subsequent characterization of the crystals by optical microscopy, powder X-ray diffraction (PXRD) and Raman spectroscopy showed quantitatively selective growth of different crystal forms at various experimental conditions. Acetaminophen crystals were grown predominantly as Form I (99%) on blank glass slides at room temperature. Form II crystals with 39% purity grown on SIFs using microwave energy.
authors.affiliation: Morgan State University, Department of Chemistry, 1700 East Cold Spring Lane, Baltimore, MD 21251.
authors.forename: Muzaffer
authors.initials: M
authors.lastname: Mohammed
authors.forename: Maleeha F
authors.initials: MF
authors.lastname: Syed
authors.forename: Mona J
authors.initials: MJ
authors.lastname: Bhatt
authors.forename: Eugene J
authors.initials: EJ
authors.lastname: Hoffman
authors.forename: Kadir
authors.initials: K
authors.lastname: Aslan