title: Design and synthesis of new 4-pyrazolin-3-yl-1,2,3-triazoles and 1,2,3-triazol-4-yl-pyrazolin-1-ylthiazoles as potential antimicrobial agents.
abstract: New pyrazolyl-1,2,3-triazoles and 1,2,3-triazol-4-yl-pyrazolylthiazoles were synthesized through multi step reactions using 1-tolylyl-4-acetyl-5-methyl-1,2,3-triazole as a precursor. All the newly synthesized compounds were characterized by spectral and elemental analyses. The structure of 11b was evidenced by X-ray crystallographic study. The newly synthesized compounds were evaluated for their antimicrobial activities and also their minimum inhibitory concentration (MIC) against most of test organisms was performed. Amongst the tested compounds 5a, 5c, 11b and 11c displayed excellent antimicrobial activity.
authors.affiliation: Applied Organic Chemistry Department, National Research Centre, Dokki, 12622 Giza, Egypt. bakrfatehy@yahoo.com
authors.forename: Bakr F
authors.initials: BF
authors.lastname: Abdel-Wahab
authors.forename: Ehab
authors.initials: E
authors.lastname: Abdel-Latif
authors.forename: Hanan A
authors.initials: HA
authors.lastname: Mohamed
authors.forename: Ghada E A
authors.initials: GE
authors.lastname: Awad
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D060326:Chemistry Techniques, Synthetic; D015195:Drug Design; D008826:Microbial Sensitivity Tests; D013844:Thiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D013844:Thiazoles; D014230:Triazoles