title: [Clinical characterization of prostate cancer potentially insignificant in the prostate biopsy].
abstract: OBJECTIVE
  The aim of this study was to identify the rate of clinical significant disease (Gleason score>6 or tumor volume>0.5 cc in the RP specimen) among patients who had an insignificant prostate cancer on biopsy, evaluating the presence of prognostic factors.
  
  
  METHODS
  Patients who fulfilled the following criteria were included: PSA ≤ 10ng/ml, T1c disease, biopsy Gleason Score ≤ 6 affecting <5% of only 1 core and who had undergone a radical prostatectomy. The following variables were studied: Age, PSA, dPSA, free/total PSA ratio and prostatic volume assessed by transrectal ultrasound.
  
  
  RESULTS
  In a series of 2424 biopsies, 77 patients completely fulfilled the inclusion criteria, with 66.23% (n=51) of clinical significant disease in the prostatectomy specimen. No differences were observed between these patients and those with insignificant disease in age, PSA, free/total PSA ratio. However, prostatic volume was significantly greater and PSA density significantly lower in those patients with an insignificant disease. Statistical analysis using a logistical regression showed that dPSA was the only prognostic factor (OR: 25067.10, CI 95%: 26.79-2.34×10(7), P=.004).
  
  
  CONCLUSIONS
  These findings suggest that a high rate of patients who have a suspected insignificant prostate cancer on biopsy have a clinical significant disease, being dPSA the only independent prognostic factor.
authors.affiliation: Servicio de Urología, Hospital Clínico Universitario de Valencia, Valencia, España. jahermed@gmail.com
authors.forename: J A
authors.initials: JA
authors.lastname: Hernández-Medina
authors.forename: F
authors.initials: F
authors.lastname: García-Morata
authors.forename: N
authors.initials: N
authors.lastname: Diez-Calzadilla
authors.forename: J M
authors.initials: JM
authors.lastname: Martínez-Jabaloyas
authors.forename: R
authors.initials: R
authors.lastname: Rodriguez-Navarro
authors.forename: P
authors.initials: P
authors.lastname: Soriano-Sarria
authors.forename: P
authors.initials: P
authors.lastname: Chuan-Nuez
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000601:surgery; D000368:Aged; D001706:Biopsy; D006801:Humans; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000473:pathology* / Q000601:surgery; D012189:Retrospective Studies; D047368:Tumor Burden