title: Inhibin α gene promoter polymorphisms in Korean women with idiopathic premature ovarian failure.
abstract: BACKGROUND
  It has been suggested that variations in the inhibin α gene (INHA) may affect the ovarian function of women. This study was performed to investigate whether the genetic polymorphisms of the INHA gene are associated with idiopathic premature ovarian failure (POF) in a Korean population.
  
  
  METHODS
  The subjects consisted of 159 idiopathic POF patients and 233 post-menopausal controls. Genotyping for the -16C>T polymorphism was performed by an minor groove binder (MGB) primer/probe Taqman assay, and the -124A>G polymorphism was identified using PCR restriction fragment length polymorphism analysis. Haplotypes were deduced by using the Haploview version 4.1.
  
  
  RESULTS
  There were no significant differences in the genotype distributions or allele frequencies of the INHA gene -16C>T and -124A>G polymorphisms between the POF and the control group. Haplotype analysis also showed no significant difference between groups.
  
  
  CONCLUSIONS
  The distribution of the INHA gene promoter polymorphisms in a Korean POF population was not significantly different from controls, implying that the INHA gene polymorphisms may not be associated with the risk of idiopathic POF.
authors.affiliation: Department of Obstetrics and Gynecology, Dongguk University, Seoul, Republic of Korea.
authors.forename: Sang Ho
authors.initials: SH
authors.lastname: Yoon
authors.forename: Young Min
authors.initials: YM
authors.lastname: Choi
authors.forename: Min A
authors.initials: MA
authors.lastname: Hong
authors.forename: Jin Ju
authors.initials: JJ
authors.lastname: Kim
authors.forename: Hyoung June
authors.initials: HJ
authors.lastname: Im
authors.forename: Gyoung Hoon
authors.initials: GH
authors.lastname: Lee
authors.forename: Byung Moon
authors.initials: BM
authors.lastname: Kang
authors.forename: Shin Yong
authors.initials: SY
authors.lastname: Moon
mesh_terms: D000328:Adult; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D007265:Inhibins / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length / Q000235:genetics; D016649:Primary Ovarian Insufficiency / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000235:genetics*; D056910:Republic of Korea
chemical_list: C094377:inhibin-alpha subunit; D007265:Inhibins