title: Angiography with a multifunctional line scanning ophthalmoscope.
abstract: A multifunctional line scanning ophthalmoscope (mLSO) was designed, constructed, and tested on human subjects. The mLSO could sequentially acquire wide-field, confocal, near-infrared reflectance, fluorescein angiography (FA), and indocyanine green angiography (ICGA) retinal images. The system also included a retinal tracker (RT) and a photodynamic therapy laser treatment port. The mLSO was tested in a pilot clinical study on human subjects with and without retinal disease. The instrument exhibited robust retinal tracking and high-contrast line scanning imaging. The FA and ICGA angiograms showed a similar appearance of hyper- and hypo-pigmented disease features and a nearly equivalent resolution of fine capillaries compared to a commercial flood-illumination fundus imager. An mLSO-based platform will enable researchers and clinicians to image human and animal eyes with a variety of modalities and deliver therapeutic beams from a single automated interface. This approach has the potential to improve patient comfort and reduce imaging session times, allowing clinicians to better diagnose, plan, and conduct patient procedures with improved outcomes.
authors.affiliation: Physical Sciences Inc., 20 New England Business Center, Andover, Massachusetts 01810, USA. hammer@psicorp.com
authors.forename: Daniel X
authors.initials: DX
authors.lastname: Hammer
authors.forename: R Daniel
authors.initials: RD
authors.lastname: Ferguson
authors.forename: Ankit H
authors.initials: AH
authors.lastname: Patel
authors.forename: Vanessa
authors.initials: V
authors.lastname: Vazquez
authors.forename: Deeba
authors.initials: D
authors.lastname: Husain
mesh_terms: D000792:Angiography / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D006801:Humans; D018613:Microscopy, Confocal / Q000295:instrumentation*; D019721:Ophthalmoscopes; D015203:Reproducibility of Results; D012161:Retinal Artery / Q000473:pathology* / Q000601:surgery*; D012164:Retinal Diseases / Q000473:pathology* / Q000601:surgery*; D012680:Sensitivity and Specificity; D016896:Treatment Outcome