title: Reduction of overall Helicobacter pylori colonization levels in the stomach of Mongolian gerbil by Lactobacillus johnsonii La1 (LC1) and its in vitro activities against H. pylori motility and adherence.
abstract: The effects of Lactobacillus johnsonii La1 (LC1) on Helicobacter pylori colonization in the stomach were investigated. H. pylori colonization and gastritis in LC1-inoculated Mongolian gerbils were significantly less intense than those in the control animals. LC1 culture supernatant (>10-kDa fraction) inhibited H. pylori motility and induced bacterial aggregation in human gastric epithelial cells, suggesting the potential of clinical use of LC1 product.
authors.affiliation: Division of Bacteriology, Department of Infectious Disease Control and International Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Isobe
authors.forename: Akihito
authors.initials: A
authors.lastname: Nishiyama
authors.forename: Tomomi
authors.initials: T
authors.lastname: Takano
authors.forename: Wataru
authors.initials: W
authors.lastname: Higuchi
authors.forename: Saori
authors.initials: S
authors.lastname: Nakagawa
authors.forename: Ikue
authors.initials: I
authors.lastname: Taneike
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Fukushima
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Yamamoto
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001422:Bacterial Adhesion / Q000187:drug effects; D015169:Colony Count, Microbial; D004195:Disease Models, Animal; D005753:Gastric Mucosa / Q000187:drug effects / Q000382:microbiology; D005756:Gastritis / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D005849:Gerbillinae; D016481:Helicobacter Infections / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D016480:Helicobacter pylori / Q000187:drug effects* / Q000254:growth & development / Q000472:pathogenicity; D006801:Humans; D007778:Lactobacillus / Q000502:physiology*; D008297:Male; D050296:Microbial Viability / Q000187:drug effects; D019936:Probiotics / Q000008:administration & dosage / Q000627:therapeutic use*; D012720:Severity of Illness Index; D013270:Stomach / Q000187:drug effects / Q000382:microbiology