title: Antiparasitic and anticancer constituents of the endophytic fungus Aspergillus sp. strain F1544.
abstract: With the combined goal of finding the best anti-parasitic and anti-cancer activities as well as isolating the bioactive agents and studying their structures and biological properties, we proceeded to perform a small-scale cultivation of Aspergillus sp. strain F1544 using Potato Dextrose, Malt Extract, Czapek Dox and Eight Vegetables media. From the more promising extracts (obtaining using potato dextrose and czapek dox media in large scale) of this fungus, we isolated the five compounds: pseurotin A (1), 14-norpseurotin A (2), FD-838 (3), and pseurotin D (4), and fumoquinone B (5). All compounds showed good antileishmanial and moderate anticancer activities.
authors.affiliation: Center for Drug Discovery, Institute for Advanced Scientific Research and High Technology Services, City of Knowledge, PO Box 0843-01103, Panama.
authors.forename: Sergio
authors.initials: S
authors.lastname: Martínez-Luis
authors.forename: Lilia
authors.initials: L
authors.lastname: Cherigo
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Arnold
authors.forename: Carmenza
authors.initials: C
authors.lastname: Spadafora
authors.forename: William H
authors.initials: WH
authors.lastname: Gerwick
authors.forename: Luis
authors.initials: L
authors.lastname: Cubilla-Rios
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000494:pharmacology*; D001230:Aspergillus / Q000737:chemistry*; D001943:Breast Neoplasms / Q000188:drug therapy; D045744:Cell Line, Tumor; D005260:Female; D006801:Humans; D007893:Leishmania donovani / Q000187:drug effects; D015394:Molecular Structure; D010961:Plasmodium / Q000187:drug effects; D014349:Trypanosoma cruzi / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D000981:Antiprotozoal Agents