title: Fecal transplant against relapsing Clostridium difficile-associated diarrhea in 32 patients.
abstract: Clostridium difficile-associated disease (CDAD) with frequent watery stools, sometimes with painful bowel movements, fever and sickness, is probably the major known cause of antibiotic-associated diarrhea and colitis, most probably depending on a disruption of the normal intestinal balance in the microbiome. In this study, we have inoculated a mixture of fecal microbes--as an enema--originating from a healthy Scandinavian middle-aged donor, regularly re-cultivated under strict anaerobic conditions for more than 10 years, to 32 patients. Twenty-two patients (69%) were durably cured. In those patients receiving the transplant by colonoscopy, four out of five were cured. To the best of our knowledge, this is the first time a fecal culture of microbes has retained the possibility for years to cure a substantial number of patients with CDAD.
authors.affiliation: Stockholm South General Hospital, Sjukhusbacken 10, Stockholm, Sweden.
authors.forename: Christina
authors.initials: C
authors.lastname: Jorup-Rönström
authors.forename: Anders
authors.initials: A
authors.lastname: Håkanson
authors.forename: Staffan
authors.initials: S
authors.lastname: Sandell
authors.forename: Ove
authors.initials: O
authors.lastname: Edvinsson
authors.forename: Tore
authors.initials: T
authors.lastname: Midtvedt
authors.forename: Anna-Karin
authors.initials: AK
authors.lastname: Persson
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Norin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use; D001421:Bacteria, Anaerobic; D001691:Biological Therapy; D016360:Clostridioides difficile; D003015:Clostridium Infections / Q000150:complications / Q000188:drug therapy; D003106:Colon / Q000382:microbiology; D003113:Colonoscopy; D003967:Diarrhea / Q000382:microbiology* / Q000628:therapy*; D004733:Enema; D005243:Feces / Q000382:microbiology*; D005260:Female; D006801:Humans; D008297:Male; D054892:Metagenome / Q000187:drug effects; D008875:Middle Aged; D012007:Rectum / Q000382:microbiology; D012008:Recurrence
chemical_list: D000900:Anti-Bacterial Agents