title: Serum thioredoxin-1 as a diagnostic marker for malignant peritoneal mesothelioma.
abstract: BACKGROUND
  Diffuse malignant peritoneal mesothelioma (DMPM) is an aggressive malignant tumor of mesothelial origin that shows a limited response to cytoreductive surgery along with intraperitoneal chemotherapy. Therefore, diagnosing DMPM early is very important. Reactive oxygen species play an important role in asbestos toxicity, which is associated with the pathogenesis of DMPM growth. Thioredoxin-1 (TRX) is a small redox-active protein that demonstrates antioxidative activity associated with tumor growth. Here, we investigated the serum levels of TRX in patients with DMPM and compared them with those of a population that had been exposed to asbestos but did not have DMPM.
  
  
  METHODS
  The serum concentrations of TRX were measured in 15 DMPM patients and 34 individuals with benign asbestos-related diseases.
  
  
  RESULTS
  We demonstrated that the patients with DMPM had significantly higher serum levels of TRX than the population that had been exposed to asbestos but did not have DMPM.
  
  
  CONCLUSIONS
  Our data suggest that serum TRX concentration is a useful serum marker for DMPM.
authors.affiliation: Department of Internal Medicine, Division of Respiratory Medicine, Hyogo College of Medicine, Hyogo, Japan. ctabata@hyo-med.ac.jp
authors.forename: Chiharu
authors.initials: C
authors.lastname: Tabata
authors.forename: Takayuki
authors.initials: T
authors.lastname: Terada
authors.forename: Rie
authors.initials: R
authors.lastname: Tabata
authors.forename: Shusai
authors.initials: S
authors.lastname: Yamada
authors.forename: Ryoji
authors.initials: R
authors.lastname: Eguchi
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Fujimori
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakano
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D055088:Early Detection of Cancer; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008654:Mesothelioma / Q000097:blood / Q000175:diagnosis*; D008875:Middle Aged; D010534:Peritoneal Neoplasms / Q000097:blood* / Q000175:diagnosis*; D011237:Predictive Value of Tests; D012372:ROC Curve; D012494:Sampling Studies; D012680:Sensitivity and Specificity; D013879:Thioredoxins / Q000097:blood*
chemical_list: D014408:Biomarkers, Tumor; D013879:Thioredoxins