title: Tumor cell expression of heat shock protein (HSP) 72 is influenced by HSP72 [HSPA1B A(1267)G] polymorphism and predicts survival in small Cell lung cancer (SCLC) patients.
abstract: The inducible heat shock protein (HSP)72 plays a central role in antitumor immunomodulation. HSP72 expression was assessed on tumor samples of 43 patients with advanced and metastatic small cell lung cancer (SCLC) by immunohistochemistry and HSP72 [HSPA1B A(1267)G] polymorphism was determined. HSP72 expression of SCLC cells was significantly decreased in GG as compared to cells of AA or AG genotype patients, and was associated with significantly shorter survival in GG patients as compared to carriers of the A allele. Decreased HSP72 expression of SCLC cells associated with HSP72 GG genotype is a negative prognostic factor for survival in SCLC patients.
authors.affiliation: Department of Pulmonology, Semmelweis University, Budapest, Hungary.
authors.forename: Klara
authors.initials: K
authors.lastname: Szondy
authors.forename: Krisztina
authors.initials: K
authors.lastname: Rusai
authors.forename: Attila J
authors.initials: AJ
authors.lastname: Szabó
authors.forename: Andrea
authors.initials: A
authors.lastname: Nagy
authors.forename: Krisztina
authors.initials: K
authors.lastname: Gal
authors.forename: Andrea
authors.initials: A
authors.lastname: Fekete
authors.forename: Zsuzsanna
authors.initials: Z
authors.lastname: Kovats
authors.forename: Gyorgy
authors.initials: G
authors.lastname: Losonczy
authors.forename: József
authors.initials: J
authors.lastname: Lukacsovits
authors.forename: Veronika
authors.initials: V
authors.lastname: Müller
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D015870:Gene Expression; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics*; D050884:HSP72 Heat-Shock Proteins / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D053208:Kaplan-Meier Estimate; D008175:Lung Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D020641:Polymorphism, Single Nucleotide; D011379:Prognosis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D055752:Small Cell Lung Carcinoma / Q000235:genetics* / Q000378:metabolism / Q000401:mortality
chemical_list: D018840:HSP70 Heat-Shock Proteins; D050884:HSP72 Heat-Shock Proteins; C525621:HSPA1B protein, human