title: From spirolactam mixtures to regioisomerically pure 5- and 6-rhodamines: a chemodosimeter-inspired strategy.
abstract: Inspired by the ring-open reaction of rhodamine spriolactams as typical chemodosimeters, a general strategy is proposed to conveniently and efficiently synthesize isomerically pure 5- and 6-R-tetramethylrhodamine on a larger scale.
authors.affiliation: State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, China.
authors.forename: Haibo
authors.initials: H
authors.lastname: Yu
authors.forename: Yi
authors.initials: Y
authors.lastname: Xiao
authors.forename: Haiying
authors.initials: H
authors.lastname: Guo
mesh_terms: D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry; D006801:Humans; D007769:Lactams / Q000737:chemistry*; D015394:Molecular Structure; D012235:Rhodamines / Q000138:chemical synthesis* / Q000737:chemistry; D013141:Spiro Compounds / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D005456:Fluorescent Dyes; D007769:Lactams; D012235:Rhodamines; D013141:Spiro Compounds; C005358:tetramethylrhodamine