title: Effects of afobazole on the content of neurotransmitter amino acids in the striatum in global transient ischemia.
abstract: Anxiolytic agent afobazole (10 mg/kg intraperitoneally) 24 h after ischemia restores impaired balance of excitatory and inhibitory amino acids in the striatum of mongrel rats, normalizes their content to control levels, and activates endogenous taurine-dependent system of neuroprotection.
authors.affiliation: V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia. veronica_xc@mail.ru
authors.forename: V S
authors.initials: VS
authors.lastname: Baykova
authors.forename: I A
authors.initials: IA
authors.lastname: Kadnikov
authors.forename: M V
authors.initials: MV
authors.lastname: Voronin
authors.forename: T S
authors.initials: TS
authors.lastname: Ganshina
authors.forename: A V
authors.initials: AV
authors.lastname: Gnezdilova
authors.forename: A A
authors.initials: AA
authors.lastname: Gorbunov
authors.forename: P C
authors.initials: PC
authors.lastname: Mirzoyan
authors.forename: S B
authors.initials: SB
authors.lastname: Seredenin
mesh_terms: D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology*; D001794:Blood Pressure; D002340:Carotid Artery Diseases / Q000188:drug therapy / Q000378:metabolism*; D017536:Carotid Artery, Common / Q000473:pathology; D004353:Drug Evaluation, Preclinical; D018846:Excitatory Amino Acids / Q000378:metabolism; D005998:Glycine / Q000378:metabolism; D002546:Ischemic Attack, Transient / Q000188:drug therapy / Q000378:metabolism*; D008297:Male; D009025:Morpholines / Q000494:pharmacology*; D017072:Neostriatum / Q000098:blood supply / Q000378:metabolism*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D018377:Neurotransmitter Agents / Q000378:metabolism*; D051381:Rats; D013654:Taurine / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: C410924:2-((2-morpholino)ethylthio)-5-ethoxybenzimidazole; D001562:Benzimidazoles; D018846:Excitatory Amino Acids; D009025:Morpholines; D018696:Neuroprotective Agents; D018377:Neurotransmitter Agents; D013654:Taurine; D005680:gamma-Aminobutyric Acid; D005998:Glycine