title: A numbers game underpins cytoplasmic mRNA transport.
abstract: Microtubule-based mRNA transport participates in the establishment of cell asymmetries. An in vitro reconstitution assay demonstrates that localization signals present in an mRNA influence motor copy number on single RNA molecule cargoes, ultimately leading to highly polarized distributions of transcripts.
authors.forename: Michael
authors.initials: M
authors.lastname: Doyle
authors.forename: Michael A
authors.initials: MA
authors.lastname: Kiebler
mesh_terms: D000818:Animals; D004331:Drosophila melanogaster; D000072159:Dynactin Complex; D004398:Dyneins / Q000378:metabolism*; D008869:Microtubule-Associated Proteins / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D000072159:Dynactin Complex; D008869:Microtubule-Associated Proteins; D012333:RNA, Messenger; D004398:Dyneins