title: ALOX5AP gene variants show differential association with coronary artery disease in different populations.
abstract: Coronary artery disease (CAD) is a complex disease with various components, genetic as well as environmental. Previous reports correlating ALOX5AP gene variants and CAD showed conflicting results depending on the population studied. In this study, we examined the contribution of ALOX5AP genetic predisposition to CAD in a group of CAD patients and controls carefully selected from the Lebanese population. We genotyped SNPs for ALOX5AP variants in 289 catheterized patients aged ≤52 years with >50% stenosis in at least one main coronary artery and 227 catheterized control subjects aged 60 years and above with 0% stenosis. Chi-square (χ                         (2)) tests and logistic regression showed no significant difference in the allele and genotype frequencies between the CAD or myocardial infarction (MI) cases and the healthy controls. Haplotype analysis using PHASE showed that the distribution of the risk haplotypes among cases and controls were not significantly different and had no attributable risk to CAD (P = 1.00 and P = 0.5, respectively) or MI (P = 0.2 and P = 0.5, respectively). Our data revealed that ALOX5AP gene variants are not predictors of CAD risk or MI risk among Lebanese patients.
authors.affiliation: The Lebanese American University, Chouran, Beirut, 1102 2801, Lebanon.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Alwan
authors.forename: Sonia C
authors.initials: SC
authors.lastname: Youhanna
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Platt
authors.forename: Mirvat
authors.initials: M
authors.lastname: El-Sibai
authors.forename: Joumana S
authors.initials: JS
authors.lastname: Yerezian
authors.forename: Mary E
authors.initials: ME
authors.lastname: Deeb
authors.forename: Georges
authors.initials: G
authors.lastname: Khazen
authors.forename: Stephanie
authors.initials: S
authors.lastname: Saadé
authors.forename: Tony G
authors.initials: TG
authors.lastname: Zreik
authors.forename: Hamid
authors.initials: H
authors.lastname: El Bayeh
authors.forename: Assaad
authors.initials: A
authors.lastname: Maalouf
authors.forename: Antoine
authors.initials: A
authors.lastname: Abchee
authors.forename: Pierre A
authors.initials: PA
authors.lastname: Zalloua