title: Naucline, a new indole alkaloid from the bark of Nauclea officinalis.
abstract: A new indole alkaloid, naucline (1) together with four known alkaloids, angustine (2), angustidine (3), nauclefine (4) and naucletine (5), were isolated from the bark of Nauclea officinalis. The structures of all isolated compounds were elucidated with various spectroscopic methods such as 1D- and 2D- NMR, IR, UV and LCMS-IT-TOF. In addition to that of alkaloid 1, the complete 13C-NMR data of naucletine (5) were also reported. Naucline (1) showed a moderate vasorelaxant activity (90% relaxation at 1 × 10(-5) M) whereas, angustine (2), nauclefine (4), and naucletine (5) showed potent vasorelaxant activity (more than 90% relaxation at 1 × 10(-5) M) on an isolated rat aorta.
authors.affiliation: Department of Chemistry, Faculty of Science, University of Malaya, 50603 Kuala Lumpur, Malaysia. khalijah@um.edu.my.
authors.forename: Sook Yee
authors.initials: SY
authors.lastname: Liew
authors.forename: Mat Ropi
authors.initials: MR
authors.lastname: Mukhtar
authors.forename: A Hamid A
authors.initials: AH
authors.lastname: Hadi
authors.forename: Khalijah
authors.initials: K
authors.lastname: Awang
authors.forename: Mohd Rais
authors.initials: MR
authors.lastname: Mustafa
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Zaima
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Morita
authors.forename: Marc
authors.initials: M
authors.lastname: Litaudon
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D066298:In Vitro Techniques; D026121:Indole Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D008297:Male; D008958:Models, Molecular; D019906:Nuclear Magnetic Resonance, Biomolecular; D024301:Plant Bark / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar; D019666:Rubiaceae / Q000737:chemistry*; D014665:Vasodilator Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D026121:Indole Alkaloids; D014665:Vasodilator Agents