title: PIWIL4 regulates cervical cancer cell line growth and is involved in down-regulating the expression of p14ARF and p53.
abstract: Recently, PIWIL4 has been identified as a functional protein involved in tumorigenesis. Cervical cancer is the second most prevalent form of cancer worldwide. The relationship between PIWIL4 and cervical cancer is still unknown. Here, we found that PIWIL4 is up-regulated in human cervical cancer tissues in comparison to adjacent normal tissues, and it promotes cell growth and proliferation by inhibiting apoptosis through the p14ARF/p53 pathway. PIWIL4 can also promote the invasion of cervical cancer cells. These results suggest that PIWIL4 might play an oncogenic role in cervical cancer and be useful as a new therapeutic target in the future.
authors.affiliation: Tianjin Life Science Research Center and Basic Medical School, Tianjin Medical University, Tianjin 300070, China.
authors.forename: Chang
authors.initials: C
authors.lastname: Su
authors.forename: Zhong-Jie
authors.initials: ZJ
authors.lastname: Ren
authors.forename: Fang
authors.initials: F
authors.lastname: Wang
authors.forename: Min
authors.initials: M
authors.lastname: Liu
authors.forename: Xin
authors.initials: X
authors.lastname: Li
authors.forename: Hua
authors.initials: H
authors.lastname: Tang
mesh_terms: D017209:Apoptosis; D060565:Argonaute Proteins / Q000378:metabolism*; D002453:Cell Cycle; D049109:Cell Proliferation; D015536:Down-Regulation; D005260:Female; D006367:HeLa Cells; D006801:Humans; D009361:Neoplasm Invasiveness; D016601:RNA-Binding Proteins; D015398:Signal Transduction; D025803:Tumor Suppressor Protein p14ARF / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*; D002583:Uterine Cervical Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology*
chemical_list: D060565:Argonaute Proteins; C556795:PIWIL4 protein, human; D016601:RNA-Binding Proteins; D025803:Tumor Suppressor Protein p14ARF; D016159:Tumor Suppressor Protein p53