title: [Characteristics of the severe fetalanomalies terminated in general obstetrics department for 4,5 years period].
abstract: The most common reason for interruption in second trimester is: Foetus mortus, malformations, severe intrauterine retardation, oligohydramnios, PPOM, cervical insufficiency, incomplete abortion. The aim of this study was to evaluate and analyze the distribution of incidence and type of severe fetal malformations, terminated at the end of first and second trimester in General obstetrical department in University hospital "Maichin dom"- Sofia for a period of 4 years and 5 months - retrospectively and prospectively.
  
  
  CONCLUSIONS
  Patients were aged between 16 and 42 years. The termination of pregnancies was in gestational period between 11.5 and 28 weeks. The study period is from the beginning of 2007 until May 2011. In the department have been terminated a total number of 907 pregnancies, 219 cases in second trimester and 61 of them due to fetal malformation, diagnozed between 11.5 to 28 weeks The incidence of fetal abnormalities was 27.8% (61 cases) of all terminated pregnancies in second trimester (219 cases). The results showed the highest rate of malformations in the age group 21-35 years - 62.3%. The highest percentage of malformations are in gestational age: 18-22 weeks - 59%. The highest incidence are as followed: neural tube defects (24.59%) and central nervous system (21.29%), followed by chromosomal defects confirmed by amniocentesis (11.47%), cardiac defects (9.83%), facial clefts (6.54%). The most common gestational age in which the anomalies are diagnosed and terminated is 18-22 weeks. The upper limit for termination of pregnancy on legislation is 22 weeks (globally 22-24 weeks). Ethical and social considerations in all cases of severe abnormalities and possible variations in physical and mental and intellectual development of the infant are discussed, these pregnancies, either diagnosed late and/or after karyotiping require termination of the pregnancy in late pregnancy
authors.forename: M
authors.initials: M
authors.lastname: Tsankova
authors.forename: B
authors.initials: B
authors.lastname: Marinov
mesh_terms: D000028:Abortion, Induced / Q000941:ethics; D000293:Adolescent; D000328:Adult; D002031:Bulgaria / Q000453:epidemiology; D005260:Female; D005315:Fetal Diseases / Q000453:epidemiology; D005333:Fetus / Q000002:abnormalities*; D006801:Humans; D009775:Obstetrics and Gynecology Department, Hospital; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011446:Prospective Studies; D012189:Retrospective Studies; D055815:Young Adult