title: Development of tropical spastic paraparesis in human T-lymphotropic virus type 1 carriers is influenced by interleukin 28B gene polymorphisms.
abstract: Interleukin 28B (IL28B) rs12979860 polymorphisms were examined in 41 individuals with human T-lymphotrophic virus type 1 (HTLV-1). The alleles CT/TT were more frequent in 12 individuals with HTLV-1-associated myelopathy/tropical spastic paraparesis than in 29 asymptomatic carriers (80% vs 20%; P = .03), and median HTLV-1 proviral load was greater in CT/TT than CC carriers (P = .01). Thus, IL28B testing and closer follow-up of HTLV-1 asymptomatic CT/TT carriers is warranted.
authors.affiliation: Hospital Carlos III, Madrid, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Treviño
authors.forename: Mariola
authors.initials: M
authors.lastname: Lopez
authors.forename: Eugenia
authors.initials: E
authors.lastname: Vispo
authors.forename: Antonio
authors.initials: A
authors.lastname: Aguilera
authors.forename: Jose M
authors.initials: JM
authors.lastname: Ramos
authors.forename: Rafael
authors.initials: R
authors.lastname: Benito
authors.forename: Lourdes
authors.initials: L
authors.lastname: Roc
authors.forename: Jose M
authors.initials: JM
authors.lastname: Eiros
authors.forename: Carmen
authors.initials: C
authors.lastname: de Mendoza
authors.forename: Vincent
authors.initials: V
authors.lastname: Soriano
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D002353:Carrier State / Q000276:immunology / Q000821:virology; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D015368:Human T-lymphotropic virus 1; D006801:Humans; D007372:Interferons; D007378:Interleukins / Q000235:genetics*; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000276:immunology / Q000821:virology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D015493:Paraparesis, Tropical Spastic / Q000235:genetics* / Q000276:immunology* / Q000821:virology; D011110:Polymorphism, Genetic; D013030:Spain; D000095022:Interferon Lambda
chemical_list: D007372:Interferons; D007378:Interleukins; C000624353:interferon-lambda, human; D000095022:Interferon Lambda