title: Successful treatment of acyclovir-resistant herpes simplex virus type 2 proctitis with leflunomide in an HIV-infected man.
abstract: Human herpes simplex virus infections are very common and represent significant morbidity in the immunocompromised host. Patients with acyclovir resistant strains of HSV based on viral thymidine kinase gene mutations need alternative therapeutic approaches. Leflunomide has been shown to possess antiviral activity against several viruses. Herein we describe a case of acyclovir resistant HSV-2 proctitis in an HIV patient successfully treated with leflunomide without significant side effects.
authors.affiliation: University of Colorado Denver, Aurora, CO 80045, USA. andres.henaomartinez@ucdenver.edu
authors.forename: Andrés F
authors.initials: AF
authors.lastname: Henao-Martínez
authors.forename: Adriana
authors.initials: A
authors.lastname: Weinberg
authors.forename: W James
authors.initials: WJ
authors.lastname: Waldman
authors.forename: Marilyn E
authors.initials: ME
authors.lastname: Levi
mesh_terms: D000212:Acyclovir / Q000494:pharmacology*; D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage* / Q000494:pharmacology*; D024882:Drug Resistance, Viral; D015658:HIV Infections / Q000150:complications; D006558:Herpes Genitalis / Q000188:drug therapy* / Q000821:virology; D018258:Herpesvirus 2, Human / Q000302:isolation & purification*; D006801:Humans; D007555:Isoxazoles / Q000008:administration & dosage*; D000077339:Leflunomide; D008297:Male; D011349:Proctitis / Q000188:drug therapy* / Q000821:virology; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D007555:Isoxazoles; D000077339:Leflunomide; D000212:Acyclovir