title: Over-expression of MAGED4B increases cell migration and growth in oral squamous cell carcinoma and is associated with poor disease outcome.
abstract: MAGE proteins have been shown to be good targets for cancer immunotherapy. We demonstrate that MAGED4B is over-expressed in more than 50% of Oral Squamous Cell Carcinoma (OSCC) tissues and the expression of MAGED4B is associated with lymph node metastasis and poor disease specific survival. OSCC cell lines that over-express MAGED4B promote migration in vitro, exhibit an increase in cell growth both in vitro and in vivo, and are more resistant to apoptosis compared to control cells. Our data suggest that MAGED4B over-expression is a driver in oral carcinogenesis and argues strongly that this protein may represent a potential therapeutic target in OSCC.
authors.affiliation: Oral Cancer Research Team, Cancer Research Initiatives Foundation (CARIF), 2nd Floor Outpatient Centre, Sime Darby Medical Centre, Selangor, Malaysia.
authors.forename: Chan Eng
authors.initials: CE
authors.lastname: Chong
authors.forename: Kue Peng
authors.initials: KP
authors.lastname: Lim
authors.forename: Chai Phei
authors.initials: CP
authors.lastname: Gan
authors.forename: Christina A
authors.initials: CA
authors.lastname: Marsh
authors.forename: Rosnah Binti
authors.initials: RB
authors.lastname: Zain
authors.forename: Mannil Thomas
authors.initials: MT
authors.lastname: Abraham
authors.forename: Stephen S
authors.initials: SS
authors.lastname: Prime
authors.forename: Soo-Hwang
authors.initials: SH
authors.lastname: Teo
authors.forename: J
authors.initials: J
authors.lastname: Silvio Gutkind
authors.forename: Vyomesh
authors.initials: V
authors.lastname: Patel
authors.forename: Sok Ching
authors.initials: SC
authors.lastname: Cheong
mesh_terms: D000368:Aged; D000951:Antigens, Neoplasm; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology*; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation; D002945:Cisplatin / Q000627:therapeutic use; D019008:Drug Resistance, Neoplasm; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000473:pathology*; D011379:Prognosis; D011836:Radiation Tolerance; D015854:Up-Regulation
chemical_list: D000951:Antigens, Neoplasm; C430404:MAGE-E1 antigen, human; D002945:Cisplatin