title: Vitamin B-complex initiates growth and development of human embryonic brain cells in vitro.
abstract: We studied a combined effect of subcomponents of vitamin B complex on the growth, development, and death of human embryonic brain-derived cells (E90) cultured using a modified method of Matson. Cell death was detected by trypan blue staining. According to our results, vitamin B-complex in low-doses promote the development, maturation, and enlargement of human embryonic brain cells, on the one hand, and increases the percent of cell death, which attests to accelerated maturation and metabolism, on the other.
authors.affiliation: G. Bunyatyan Institute of Biochemistry, National Academy of Sciences of Armenia, Yerevan, Armenia. Kristine_danielyan@biochem.sci.am
authors.forename: K E
authors.initials: KE
authors.lastname: Danielyan
authors.forename: R A
authors.initials: RA
authors.lastname: Abramyan
authors.forename: A A
authors.initials: AA
authors.lastname: Galoyan
authors.forename: G A
authors.initials: GA
authors.lastname: Kevorkian
mesh_terms: D001921:Brain / Q000166:cytology*; D016923:Cell Death / Q000187:drug effects; D049108:Cell Enlargement / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D004622:Embryo, Mammalian / Q000166:cytology*; D058732:Embryoid Bodies / Q000166:cytology / Q000187:drug effects; D006801:Humans; D009474:Neurons / Q000502:physiology*; D009536:Niacinamide / Q000494:pharmacology; D011736:Pyridoxine / Q000494:pharmacology; D012256:Riboflavin / Q000494:pharmacology; D013831:Thiamine / Q000494:pharmacology; D014803:Vitamin B Complex / Q000494:pharmacology*
chemical_list: D014803:Vitamin B Complex; D009536:Niacinamide; D011736:Pyridoxine; D012256:Riboflavin; D013831:Thiamine