title: A VLSI field-programmable mixed-signal array to perform neural signal processing and neural modeling in a prosthetic system.
abstract: A very-large-scale integration field-programmable mixed-signal array specialized for neural signal processing and neural modeling has been designed. This has been fabricated as a core on a chip prototype intended for use in an implantable closed-loop prosthetic system aimed at rehabilitation of the learning of a discrete motor response. The chosen experimental context is cerebellar classical conditioning of the eye-blink response. The programmable system is based on the intimate mixing of switched capacitor analog techniques with low speed digital computation; power saving innovations within this framework are presented. The utility of the system is demonstrated by the implementation of a motor classical conditioning model applied to eye-blink conditioning in real time with associated neural signal processing. Paired conditioned and unconditioned stimuli were repeatedly presented to an anesthetized rat and recordings were taken simultaneously from two precerebellar nuclei. These paired stimuli were detected in real time from this multichannel data. This resulted in the acquisition of a trigger for a well-timed conditioned eye-blink response, and repetition of unpaired trials constructed from the same data led to the extinction of the conditioned response trigger, compatible with natural cerebellar learning in awake animals.
authors.affiliation: Istituto Superiore di Sanità, Rome, Italy. simeon.bamford@iss.infn.it
authors.forename: Simeon A
authors.initials: SA
authors.lastname: Bamford
authors.forename: Roni
authors.initials: R
authors.lastname: Hogri
authors.forename: Andrea
authors.initials: A
authors.lastname: Giovannucci
authors.forename: Aryeh H
authors.initials: AH
authors.lastname: Taub
authors.forename: Ivan
authors.initials: I
authors.lastname: Herreros
authors.forename: Paul F M J
authors.initials: PF
authors.lastname: Verschure
authors.forename: Matti
authors.initials: M
authors.lastname: Mintz
authors.forename: Paolo
authors.initials: P
authors.lastname: Del Giudice
mesh_terms: D000818:Animals; D001767:Blinking / Q000502:physiology*; D002531:Cerebellum / Q000502:physiology*; D003198:Computer Simulation; D003214:Conditioning, Classical / Q000502:physiology; D004558:Electric Stimulation / Q000295:instrumentation*; D004569:Electroencephalography / Q000295:instrumentation*; D004867:Equipment Design; D019544:Equipment Failure Analysis; D008959:Models, Neurological; D019736:Prostheses and Implants; D051381:Rats; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation*; D014584:User-Computer Interface