title: In silico prediction of toxic action mechanisms of phenols for imbalanced data with Random Forest learner.
abstract: With an increasing need for the rapid and effective safety assessment of compounds in industrial and civil-use products, in silico toxicity exploration techniques provide an economic way for environmental hazard assessment. The previous in silico researches have developed many quantitative structure-activity relationships models to predict toxicity mechanisms for last decade. Most of these methods benefit from data analysis and machine learning techniques, which rely heavily on the characteristics of data sets. For Tetrahymena pyriformis toxicity data sets, there is a great technical challenge-data imbalance. The skewness of data class distribution would greatly deteriorate the prediction performance on rare classes. Most of the previous researches for phenol mechanisms of toxic action prediction did not consider this practical problem. In this work, we dealt with the problem by considering the difference between the two types of misclassifications. Random Forest learner was employed in cost-sensitive learning framework to construct prediction models based on selected molecular descriptors. In computational experiments, both the global and local models obtained appreciable overall prediction accuracies. Particularly, the performance on rare classes was indeed promoted. Moreover, for practical usage of these models, the balance of the two misclassifications can be adjusted by using different cost matrices according to the application goals.
authors.affiliation: College of Computer Science, Chongqing University, Chongqing 400030, China. chenjingmc@gmail.com
authors.forename: Jing
authors.initials: J
authors.lastname: Chen
authors.forename: Yuan Yan
authors.initials: YY
authors.lastname: Tang
authors.forename: Bin
authors.initials: B
authors.lastname: Fang
authors.forename: Chang
authors.initials: C
authors.lastname: Guo
mesh_terms: D000465:Algorithms; D019540:Area Under Curve; D001185:Artificial Intelligence; D003198:Computer Simulation; D003663:Decision Trees; D004785:Environmental Pollutants / Q000633:toxicity*; D008956:Models, Chemical; D010636:Phenols / Q000633:toxicity*; D021281:Quantitative Structure-Activity Relationship; D012372:ROC Curve
chemical_list: D004785:Environmental Pollutants; D010636:Phenols