title: Clinical, dermoscopic and reflectance confocal microscopy features of sebaceous neoplasms in Muir-Torre syndrome.
abstract: BACKGROUND
  Muir-Torre syndrome (MTS) is an autosomal-dominant disorder characterized by the association of sebaceous tumors or keratoacanthomas with an early onset visceral cancer in the spectrum of Lynch syndrome.
  
  
  METHODS
  A total of 20 sebaceous tumors including 18 sebaceous adenoma and two sebaceomas of six patients with MTS were analysed. Two main clinico-dermoscopic features were observed: (1) clinically pink to white papules/nodules with a central crater, dermoscopically characterized by radially arranged, elongated crown vessels surrounding opaque structureless yellow areas at times covered by blood crusts (n = 13) and (2), clinically pink to yellow papules/nodules without a central crater, dermoscopically exhibiting a few, loosely arranged yellow comedo-like globules and branching arborizing vessels (n = 7). Confocal microscopy was available in three sebaceous adenomas and revealed a good histopathologic correlation; sebaceous lobules were composed by clusters of ovoid cells with dark nuclei and bright, highly refractile glistening cytoplasm. They were delimited by a rim of epithelial cells, corresponding to basaloid cells.
  
  
  CONCLUSIONS
  A better characterization of clinical, dermoscopic and confocal microscopy features of sebaceous tumors may improve their recognition and consequently, aid to rise the suspect for MTS.
authors.affiliation: Department of Oncologic Dermatology, San Gallicano Dermatologic Institute, Rome, Italy. uhara@shinshu-u.ac.jp
authors.forename: E
authors.initials: E
authors.lastname: Moscarella
authors.forename: G
authors.initials: G
authors.lastname: Argenziano
authors.forename: C
authors.initials: C
authors.lastname: Longo
authors.forename: C
authors.initials: C
authors.lastname: Cota
authors.forename: M
authors.initials: M
authors.lastname: Ardigò
authors.forename: V
authors.initials: V
authors.lastname: Stigliano
authors.forename: L S
authors.initials: LS
authors.lastname: Mete
authors.forename: P
authors.initials: P
authors.lastname: Donati
authors.forename: S
authors.initials: S
authors.lastname: Piana
authors.forename: V
authors.initials: V
authors.lastname: Silipo
authors.forename: C
authors.initials: C
authors.lastname: Catricalà
authors.forename: G
authors.initials: G
authors.lastname: Albertini
authors.forename: I
authors.initials: I
authors.lastname: Zalaudek
mesh_terms: D000236:Adenoma / Q000150:complications / Q000473:pathology; D000368:Aged; D046169:Dermoscopy; D005260:Female; D006801:Humans; D008297:Male; D018613:Microscopy, Confocal; D008875:Middle Aged; D055653:Muir-Torre Syndrome / Q000150:complications*; D012189:Retrospective Studies; D012626:Sebaceous Gland Neoplasms / Q000150:complications* / Q000473:pathology*