title: Cardiac metastasis of hepatocellular carcinoma in a young non-cirrhotic patient, to the left ventricle.
abstract: Hepatocellular carcinoma (HCC) is the most common primary tumor of the liver.(1,2) The most common extrahepatic metastatic sites are lung, abdominal lymph nodes and bone, while its cardiac metastasis is rare.(2,3) Metastasis of HCC into the cardiac cavity is mostly caused by direct tumor invasion of vena cava inferior with continuous extension into the right cardiac cavity.(4,5) Right heart metastasis without invasion of inferior vena cava, which may be caused by hematogenous spread of cancer cells, is rarely reported.(6,7) This paper announces an unusual case of isolated involvement of left ventricle (LV) together with myocardial invasion of HCC. Our patient is known to be the first case with isolated HCC metastasis to the left ventricle. Strikingly, the patient was young and non-cirrhotic with negative serum HBsAg, and anti-HCV results.
authors.affiliation: Trakya University Medical Faculty, Department of Pathology, Edirne, Turkey. ebrutastekin@hotmail.com
authors.forename: Ebru
authors.initials: E
authors.lastname: Tastekin
authors.forename: Ufuk
authors.initials: U
authors.lastname: Usta
authors.forename: Turan
authors.initials: T
authors.lastname: Ege
authors.forename: Gokhan
authors.initials: G
authors.lastname: Kazindir
authors.forename: Ali Kemal
authors.initials: AK
authors.lastname: Kutlu
mesh_terms: D001707:Biopsy, Needle; D006528:Carcinoma, Hepatocellular / Q000473:pathology*; D017809:Fatal Outcome; D006338:Heart Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary*; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology*; D008297:Male; D009102:Multiple Organ Failure / Q000401:mortality; D014057:Tomography, X-Ray Computed; D055815:Young Adult