title: The effects of fever on hormone ghrelins, immunoglobulins, and heat shock protein 70 expression after swine flu vaccinations.
abstract: For analyzing the changes in immunoglobulins, HSP70, ghrelin levels in blood samples were collected from volunteers vaccinated against swine flu before the vaccinations and on days 3, and 15, and 1 and 2 months after the vaccination in the presence or absence of fever associated with the it. The study included 11 subjects having developed a fever, and 13 subjects not having a fever, and 20 control subjects. Immunoglobulins were measured by nephelometry, and HSP70 and ghrelins by appropriate ELISA tests. The level of ghrelin was reduced, while the level of HSP70 was significantly increased in subjects who developed fevers. When temperatures were normalized, both levels were found similar to the control group. These results indicate that the increase in serum immunoglobulins levels associated with vaccinations, along with, elevations in HSP70 and reduced ghrelin levels associated with fever, may be the important parameters in the clinical evaluation and follow-up of treatments with vaccines.
authors.affiliation: Department of Medical Biochemistry and Clinical Biochemistry (Firat Hormones Research Group), Medical School, Firat University, 23119 Elazig, Turkey. saydin1@hotmail.com
authors.forename: Suleyman
authors.initials: S
authors.lastname: Aydin
authors.forename: Tumer
authors.initials: T
authors.lastname: Guven
authors.forename: İbrahim
authors.initials: İ
authors.lastname: Sahin
authors.forename: Aziz
authors.initials: A
authors.lastname: Aksoy
authors.forename: Yalçın
authors.initials: Y
authors.lastname: Kendir
authors.forename: Mustafa N
authors.initials: MN
authors.lastname: İlhan
authors.forename: Cihan
authors.initials: C
authors.lastname: Citil
authors.forename: Zekiye
authors.initials: Z
authors.lastname: Catak
authors.forename: Cemal
authors.initials: C
authors.lastname: Ustun
mesh_terms: D000107:Acetylation; D000328:Adult; D015536:Down-Regulation; D005260:Female; D005334:Fever / Q000097:blood* / Q000453:epidemiology / Q000209:etiology / Q000276:immunology; D054439:Ghrelin / Q000097:blood* / Q000378:metabolism; D018840:HSP70 Heat-Shock Proteins / Q000097:blood*; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007136:Immunoglobulins / Q000097:blood*; D053118:Influenza A Virus, H1N1 Subtype / Q000276:immunology*; D007252:Influenza Vaccines / Q000009:adverse effects* / Q000276:immunology; D007251:Influenza, Human / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D014421:Turkey / Q000453:epidemiology; D015854:Up-Regulation; D014611:Vaccination / Q000009:adverse effects
chemical_list: C515349:GHRL protein, human; D054439:Ghrelin; D018840:HSP70 Heat-Shock Proteins; C490786:HSPA1A protein, human; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D007252:Influenza Vaccines