title: Drug susceptibility of Mycobacterium tuberculosis Beijing genotype and association with MDR TB.
abstract: To determine differences in the ability of Mycobacterium tuberculosis strains to withstand antituberculosis drug treatment, we compared the activity of antituberculosis drugs against susceptible Beijing and East-African/Indian genotype M. tuberculosis strains. Beijing genotype strains showed high rates of mutation within a wide range of drug concentrations, possibly explaining this genotype's association with multidrug-resistant tuberculosis.
authors.affiliation: Erasmus University Medical Center, Rotterdam, the Netherlands. j.desteenwinkel@erasmusmc.nl
authors.forename: Jurriaan E M
authors.initials: JE
authors.lastname: de Steenwinkel
authors.forename: Marian T
authors.initials: MT
authors.lastname: ten Kate
authors.forename: Gerjo J
authors.initials: GJ
authors.lastname: de Knegt
authors.forename: Kristin
authors.initials: K
authors.lastname: Kremer
authors.forename: Rob E
authors.initials: RE
authors.lastname: Aarnoutse
authors.forename: Martin J
authors.initials: MJ
authors.lastname: Boeree
authors.forename: Henri A
authors.initials: HA
authors.lastname: Verbrugh
authors.forename: Dick
authors.initials: D
authors.lastname: van Soolingen
authors.forename: Irma A J M
authors.initials: IA
authors.lastname: Bakker-Woudenberg
mesh_terms: D000583:Amikacin / Q000494:pharmacology; D000995:Antitubercular Agents / Q000494:pharmacology*; D001372:Aza Compounds / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D024841:Fluoroquinolones; D005838:Genotype; D007538:Isoniazid / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D000077266:Moxifloxacin; D009154:Mutation; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000235:genetics; D011804:Quinolines / Q000494:pharmacology; D012293:Rifampin / Q000494:pharmacology; D018709:Statistics, Nonparametric; D018088:Tuberculosis, Multidrug-Resistant / Q000382:microbiology*
chemical_list: D000995:Antitubercular Agents; D001372:Aza Compounds; D001426:Bacterial Proteins; D024841:Fluoroquinolones; D011804:Quinolines; D000583:Amikacin; D000077266:Moxifloxacin; D007538:Isoniazid; D012293:Rifampin