title: Study on the expression of co-stimulatory marker CD134 on CD4+ T cells in HIV-1-infected individuals.
abstract: CD4+CD25+CD134+ T cells play an important role in suppressing T cell responses to foreign pathogens, including human immunodeficiency virus (HIV). Thus, we aimed to investigate an increase in these populations in HIV-1-infected individuals. In this study, we used a panel of monoclonal antibodies staining of CD3/CD4/CD25/CD134. Without antigen stimulation, the expression of CD4+CD25+CD134+ T cells in 14 HIV-1-infected and 24 healthy individuals were 4.01% and 3.21%, respectively. However, there was an increase in the expression of CD4 + CD25+CD134+ T cells in HIV-1-infected individuals (6.85%) when stimulated with gag peptide. The upregulation of CD4+CD25+CD134+ T cells in HIV-1-infected individuals may result from activation of naturally occurring or by disease-associated antigen stimulation.
authors.affiliation: Department of Transfusion Medicine, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, Thailand.
authors.forename: Ammaranond
authors.initials: A
authors.lastname: Palanee
authors.forename: Thantiworasit
authors.initials: T
authors.lastname: Pattarawat
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology; D015415:Biomarkers / Q000032:analysis; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism*; D015658:HIV Infections / Q000276:immunology*; D006801:Humans; D053262:Receptors, OX40 / Q000032:analysis / Q000276:immunology / Q000378:metabolism*
chemical_list: D000911:Antibodies, Monoclonal; D015415:Biomarkers; D053262:Receptors, OX40; C505716:TNFRSF4 protein, human