title: Immunoglobulin A nephropathy associated with Plasmodium falciparum malaria.
abstract: Glomerulonephritis occurs as a rare form of renal manifestation in Plasmodium falciparum malaria. Herein, we report a case of falciparum malaria-associated IgA nephropathy for the first time. A 49-yr old male who had been to East Africa was diagnosed with Plasmodium falciparum malaria. Microhematuria and proteinuria along with acute kidney injury developed during the course of the disease. Kidney biopsy showed mesangial proliferation and IgA deposits with tubulointerstitial inflammation. Laboratory tests after recovery from malaria showed disappearance of urinary abnormalities and normalization of kidney function. Our findings suggest that malaria infection might be associated with IgA nephropathy.
authors.affiliation: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: Dong Eun
authors.initials: DE
authors.lastname: Yoo
authors.forename: Jeong Ho
authors.initials: JH
authors.lastname: Kim
authors.forename: Jeong Hae
authors.initials: JH
authors.lastname: Kie
authors.forename: Yoonseon
authors.initials: Y
authors.lastname: Park
authors.forename: Tae Ik
authors.initials: TI
authors.lastname: Chang
authors.forename: Hyung Jung
authors.initials: HJ
authors.lastname: Oh
authors.forename: Seung Jun
authors.initials: SJ
authors.lastname: Kim
authors.forename: Tae-Hyun
authors.initials: TH
authors.lastname: Yoo
authors.forename: Kyu Hun
authors.initials: KH
authors.lastname: Choi
authors.forename: Shin-Wook
authors.initials: SW
authors.lastname: Kang
authors.forename: Seung Hyeok
authors.initials: SH
authors.lastname: Han
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology / Q000473:pathology; D000962:Antimalarials / Q000627:therapeutic use; D003404:Creatinine / Q000097:blood; D005922:Glomerulonephritis, IGA / Q000175:diagnosis* / Q000209:etiology*; D006417:Hematuria / Q000209:etiology; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism*; D008288:Malaria / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010963:Plasmodium falciparum / Q000302:isolation & purification*; D011507:Proteinuria / Q000209:etiology; D011803:Quinine / Q000627:therapeutic use
chemical_list: D000962:Antimalarials; D007070:Immunoglobulin A; D011803:Quinine; D003404:Creatinine