title: Cancer morbidity among methyl isocyanate exposed long- term survivors and their offspring: a hospital-based five year descriptive study (2006 - 2011) and future directions to predict cancer risk in the affected population.
abstract: The purpose of this study was to update both researchers and clinicians about the cancer incidence in methyl isocyanate (MIC) exposed long-term survivors and in their offspring, focusing on the etiological plausibility. In the time period 2006-2011, cancer morbidity was evaluated in the population surviving after exposure to (MIC) on December 3rd, 1984, in Bhopal. This descriptive study is based on hospital registration of 1261 cancer patients those are MIC gas victims and their subsequently born offspring. Morbidity status was studied on the basis of gender, age, organ and site with relative percentages. Cancers on specific sites, with special reference to breast (n=231) (18.31%), lung (n=103) (8.16%), tongue (n=103) (8.16%), buccal mucosa (n=94) (7.45%), cervix (n=72) (5.70%), and esophagus (n=68) (5.39%) were found in high proportions. Ovary (n=43) (3.40%), brain (n=42) (3.33%), larynx (n=40) (3.17%), non-Hodgkin's (n=31) (2.45%), gallbladder (n=29) (2.29%), stomach (n=28) (2.22%), head and neck (n=28) (2.22%), liver (n=27) (2.14%), acute lymphoid leukemia (n=24) (1.90%), rectum (n=20) (1.58%), colon (n=20) (1.58%), chronic myeloid leukemia (n=17) (1.34%), alveolus (n=17) (1.34%), Hodgkin's (n=14) (1.11%), uterus (n=14) (1.11%), multiple myeloma (n=14) (1.11%), and prostate (n=11) (0.87%) lesions were observed less frequently. Remarkably, gradual increase of cancers on different organs and sites were observed in the long- term survivors and their offspring. The present study observed some cancers which were not previously reported in this population. In addition, we also present the future research directions with systematic approaches to predict cancer risk in long-term survivors and their future generations. On the basis of this morbidity report, we suggest the need of biological surveillance through immune system biomonitoring and cytogenetic screening to predict the cancer risk in the MIC exposed population and their offspring.
authors.affiliation: Department of Research, Jawaharlal Nehru Cancer Hospital and Research Centre, India. sengenetics@gmail.com
authors.forename: Chinnu Sugavanam
authors.initials: CS
authors.lastname: Senthilkumar
authors.forename: Tahir Mohi-ud-Din
authors.initials: TM
authors.lastname: Malla
authors.forename: Nand Kishore
authors.initials: NK
authors.lastname: Sah
authors.forename: Narayanan
authors.initials: N
authors.lastname: Ganesh
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000986:Antisickling Agents / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D005190:Family; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D017953:Isocyanates / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D009369:Neoplasms / Q000139:chemically induced* / Q000453:epidemiology / Q000401:mortality*; D011379:Prognosis; D015996:Survival Rate; D017741:Survivors / Q000706:statistics & numerical data*; D055815:Young Adult
chemical_list: D000986:Antisickling Agents; D017953:Isocyanates; C008461:methyl isocyanate