title: Primary systemic amyloidosis associated with multiple myeloma.
abstract: This case report is about a 48-year-old female patient with systemic amyloidosis and multiple myeloma simultaneously. Amyloid cutaneous infiltrative lesions like papules, nodules, or plaques with a serous-hemorrhagic aspect were found in the eyelids, neck and retroauricular region, among others. She had presented intermittent papular lesions on the upper eyelids one year before, which worsened following local trauma. A local skin biopsy showed amorphous and eosinophilic substance in the dermis. Congo red staining confirmed the amyloid deposits. Abnormal exams: proteinuria (570 mg/24h), Bence-Jones proteinuria and clonal plasma cells (70%) found in myelogram. Following the diagnosis of multiple myeloma based on amyloid skin lesions, the patient was referred to the Hematology service and died 5 months after the diagnosis.
authors.affiliation: Medical School, Faculdade de Medicina de São José do Rio Preto, SP, Brazil. edersonvlo@yahoo.com.br
authors.forename: Ederson Valei Lopes de
authors.initials: EV
authors.lastname: Oliveira
authors.forename: Ana Carolina Garcia
authors.initials: AC
authors.lastname: Pozetti
authors.forename: Eurides Maria de Oliveira
authors.initials: EM
authors.lastname: Pozetti
authors.forename: João Roberto
authors.initials: JR
authors.lastname: Antonio
authors.forename: Nilceo Schwery
authors.initials: NS
authors.lastname: Michalany
mesh_terms: D000686:Amyloidosis / Q000150:complications / Q000473:pathology*; D003224:Congo Red; D005143:Eyelids / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008875:Middle Aged; D009101:Multiple Myeloma / Q000209:etiology / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology*
chemical_list: D003224:Congo Red