title: Au@SiO2 core-shell nanoparticles for laser desorption/ionization time of flight mass spectrometry.
abstract: In matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF-MS), the analysis capability, especially for small molecules, is often compromised by the addition of organic matrices due to the existence of background signals. Herein we report a new detection method on the utility of core-shell nanoparticles (CSNPs) as energy transfer structure in LDI-TOF-MS. The LDI-TOF-MS based on gold-silica core-shell nanoparticles with ultrathin silica shell of 2-4 nm (Au@utSiO(2) CSNPs) was effectively applied to the analysis of many compounds, especially for small functional molecules and polymers, which was more promising than MALDI-TOF-MS.
authors.affiliation: Department of Polymer Science and Engineering, School of Chemistry and Chemical Engineering, State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, China.
authors.forename: Xiaoqing
authors.initials: X
authors.lastname: Zhu
authors.forename: Lianglan
authors.initials: L
authors.lastname: Wu
authors.forename: Divyesh C
authors.initials: DC
authors.lastname: Mungra
authors.forename: Sijing
authors.initials: S
authors.lastname: Xia
authors.forename: Jin
authors.initials: J
authors.lastname: Zhu
mesh_terms: D004735:Energy Transfer; D006046:Gold / Q000737:chemistry*; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D011092:Polyethylene Glycols / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry*; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
chemical_list: D011108:Polymers; D011092:Polyethylene Glycols; D006046:Gold; D012822:Silicon Dioxide