title: Blood component support in acquired coagulopathic conditions: is there a method to the madness?
abstract: Acquired coagulopathies are often detected by laboratory investigation in clinical practice. There is a poor correlation between mild to moderate abnormalities of laboratory test and bleeding tendency. Patients who are bleeding due to coagulopathy are often managed with various blood components including plasma, platelets, and cryoprecipitate. However, prophylactic transfusion of these products in a nonbleeding patient to correct mild to moderate abnormality of a coagulation test especially preprocedure is not evidence-based. This article reviews the management of bleeding due to oral anticoagulants and antiplatelet agents, disseminated intravascular coagulation, chronic liver disease, and trauma.
authors.affiliation: Division of Transfusion Medicine and Hemostasis, Department of Pathology, UT Southwestern Medical Center, Dallas, Texas 75390-9073, USA.
authors.forename: Trailokya Nath
authors.initials: TN
authors.lastname: Pandit
authors.forename: Ravindra
authors.initials: R
authors.lastname: Sarode
mesh_terms: D000925:Anticoagulants / Q000009:adverse effects; D001780:Blood Coagulation Tests / Q000379:methods; D016913:Blood Component Transfusion; D002908:Chronic Disease; D004211:Disseminated Intravascular Coagulation / Q000097:blood / Q000150:complications / Q000628:therapy*; D006470:Hemorrhage / Q000097:blood / Q000139:chemically induced / Q000209:etiology / Q000628:therapy*; D006801:Humans; D008107:Liver Diseases / Q000150:complications / Q000628:therapy; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects; D014947:Wounds and Injuries / Q000150:complications / Q000628:therapy
chemical_list: D000925:Anticoagulants; D010975:Platelet Aggregation Inhibitors