title: Controlled release of triamcinolone acetonide from polyurethane implantable devices: application for inhibition of inflammatory-angiogenesis.
abstract: The purpose of this study was to develop triamcinolone acetonide-loaded polyurethane implants (TA PU implants) for the local treatment of different pathologies including arthritis, ocular and neuroinflammatory disorders. The TA PU implants were characterized by FTIR, SAXS and WAXS. The in vitro and in vivo release of TA from the PU implants was evaluated. The efficacy of TA PU implants in suppressing inflammatory-angiogenesis in a murine sponge model was demonstrated. FTIR results revealed no chemical interactions between polymer and drug. SAXS results indicated that the incorporation of the drug did not disturb the polymer morphology. WAXS showed that the crystalline nature of the TA was preserved after incorporation into the PU. The TA released from the PU implants efficiently inhibited the inflammatory-angiogenesis induced by sponge discs in an experimental animal model. Finally, TA PU implants could be used as local drug delivery systems because of their controlled delivery of TA.
authors.affiliation: School of Pharmacy, Federal University of São João Del Rei, Chanadour, Divinópolis, Minas Gerais, Brazil.
authors.forename: Flávia Carmo Horta
authors.initials: FC
authors.lastname: Pinto
authors.forename: Armando
authors.initials: A
authors.lastname: Da Silva-Cunha Junior
authors.forename: Rodrigo Lambert
authors.initials: RL
authors.lastname: Oréfice
authors.forename: Eliane
authors.initials: E
authors.lastname: Ayres
authors.forename: Silvia Passos
authors.initials: SP
authors.lastname: Andrade
authors.forename: Luiza Dias C
authors.initials: LD
authors.lastname: Lima
authors.forename: Sandra A Lima
authors.initials: SA
authors.lastname: Moura
authors.forename: Gisele Rodrigues
authors.initials: GR
authors.lastname: Da Silva
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D001672:Biocompatible Materials / Q000737:chemistry; D003692:Delayed-Action Preparations; D004195:Disease Models, Animal; D016503:Drug Delivery Systems; D004343:Drug Implants / Q000737:chemistry; D005260:Female; D007249:Inflammation / Q000517:prevention & control*; D008422:Materials Testing; D051379:Mice; D008855:Microscopy, Electron, Scanning; D009389:Neovascularization, Pathologic / Q000517:prevention & control*; D011140:Polyurethanes / Q000737:chemistry; D053838:Scattering, Small Angle; D017550:Spectroscopy, Fourier Transform Infrared; D014222:Triamcinolone Acetonide / Q000008:administration & dosage*; D014961:X-Ray Diffraction
chemical_list: D000893:Anti-Inflammatory Agents; D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D004343:Drug Implants; D011140:Polyurethanes; D014222:Triamcinolone Acetonide