title: A novel antioxidant isobenzofuranone derivative from fungus Cephalosporium sp.AL031.
abstract: Bioassay-guided fractionation of metabolites from the fungus Cephalosporium sp.AL031 isolated from Sinarundinaria nitida led to the discovery of a new isobenzofuranone derivative, 4,6-dihydroxy-5-methoxy-7-methylphthalide (1), together with three known compounds: 4,5,6-trihydroxy-7-methyl-1,3-dihydroisobenzofuran (2), 4,6-dihydroxy-5-methoxy-7-methyl-1,3-dihydroisobenzofuran (3) and 4,5,6-trihydroxy-7-methylphthalide (4). The structure of the new compound 1 was determined based on MS, 1D and 2D NMR spectral data. Compounds 1-4 showed potent antioxidant activity with EC₅₀ values of 10, 7, 22 and 5 μM by 1,1-diphenyl-2-picryhydrazyl (DPPH) radical-scavenging assay.
authors.affiliation: Key Laboratory of Ethnic Medicine Resource Chemistry, State Ethnic Affairs Commission & Ministry of Education, School of Chemistry and Biotechnology, Yunnan University of Nationalities, Kunming 650500, China.
authors.forename: Xiang-Zhong
authors.initials: XZ
authors.lastname: Huang
authors.forename: Yun
authors.initials: Y
authors.lastname: Zhu
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Guan
authors.forename: Kai
authors.initials: K
authors.lastname: Tian
authors.forename: Jun-Ming
authors.initials: JM
authors.lastname: Guo
authors.forename: Hong-Bin
authors.initials: HB
authors.lastname: Wang
authors.forename: Guang-Miao
authors.initials: GM
authors.lastname: Fu
mesh_terms: D000164:Acremonium / Q000737:chemistry*; D000975:Antioxidants / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology*; D001572:Benzofurans / Q000032:analysis / Q000737:chemistry / Q000494:pharmacology*; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: C573596:4,6-dihydroxy-5-methoxy-7-methylphthalide; D000975:Antioxidants; D001572:Benzofurans