title: Risk factors for colonic diverticular hemorrhage: Japanese multicenter study.
abstract: OBJECTIVE
  Diverticular hemorrhage is the common cause of lower gastrointestinal bleeding, and its incidence has been increasing in Japan. However, the exact cause of diverticular hemorrhage is not well understood. We investigated the risk factors for diverticular hemorrhage.
  
  
  METHODS
  We selected 103 patients with diverticular hemorrhage as cases and patients with colonic diverticulosis without a history of bleeding were selected as control subjects, exactly matched for age and gender. We collected the data from the medical records of each of the patients, such as those related to the comorbidities, medications and findings of colonoscopy, and conducted a matched case-control study to analyze the risk factors for diverticular hemorrhage.
  
  
  RESULTS
  Both groups were composed of 75 men and 28 women. The median age of the patients in both groups was 72.0 years (47.0-87.0). The body weight (p = 0.0065), body mass index (p = 0.006), prevalence of hypertension (p = 0.0242), prevalence of ischemic heart disease (p = 0.0015), and frequency of use of low-dose aspirin (p = 0.042) were significantly different between the two groups. The percentage of patients with bilateral diverticula, that is, diverticula on both the right and left hemicolon, was significantly higher in the diverticular hemorrhage group (p = 0.0011). Multiple regression analysis identified only the diverticular location as being significantly associated with the risk of diverticular hemorrhage (p = 0.0021).
  
  
  CONCLUSIONS
  Only the diverticular location (bilateral) was found to be an independent risk factor for diverticular hemorrhage.
authors.affiliation: Department of Gastroenterology, Yokohama Rosai Hospital, Yokohama, Japan.
authors.forename: Kaori
authors.initials: K
authors.lastname: Suzuki
authors.forename: Shiori
authors.initials: S
authors.lastname: Uchiyama
authors.forename: Kento
authors.initials: K
authors.lastname: Imajyo
authors.forename: Wataru
authors.initials: W
authors.lastname: Tomeno
authors.forename: Eiji
authors.initials: E
authors.lastname: Sakai
authors.forename: Eiji
authors.initials: E
authors.lastname: Yamada
authors.forename: Emiko
authors.initials: E
authors.lastname: Tanida
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Akiyama
authors.forename: Seitaro
authors.initials: S
authors.lastname: Watanabe
authors.forename: Hiroki
authors.initials: H
authors.lastname: Endo
authors.forename: Koji
authors.initials: K
authors.lastname: Fujita
authors.forename: Masato
authors.initials: M
authors.lastname: Yoneda
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Takahashi
authors.forename: Tomoko
authors.initials: T
authors.lastname: Koide
authors.forename: Chikako
authors.initials: C
authors.lastname: Tokoro
authors.forename: Yasunobu
authors.initials: Y
authors.lastname: Abe
authors.forename: Minoru
authors.initials: M
authors.lastname: Kawaguchi
authors.forename: Eiji
authors.initials: E
authors.lastname: Gotoh
authors.forename: Shin
authors.initials: S
authors.lastname: Maeda
authors.forename: Atsushi
authors.initials: A
authors.lastname: Nakajima
authors.forename: Masahiko
authors.initials: M
authors.lastname: Inamori
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001241:Aspirin / Q000009:adverse effects*; D015992:Body Mass Index; D016022:Case-Control Studies; D004241:Diverticulum, Colon / Q000150:complications* / Q000453:epidemiology; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000150:complications* / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D006973:Hypertension / Q000150:complications*; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000150:complications*; D010975:Platelet Aggregation Inhibitors / Q000009:adverse effects*; D012044:Regression Analysis; D012307:Risk Factors
chemical_list: D010975:Platelet Aggregation Inhibitors; D001241:Aspirin