title: Structure-based macrocyclization yields hepatitis C virus NS5B inhibitors with improved binding affinities and pharmacokinetic properties.
authors.affiliation: Janssen Infectious Diseases BVBA, Turnhoutseweg 30, 2340 Beerse, Belgium. mcummin1@its.jnj.com
authors.forename: Maxwell D
authors.initials: MD
authors.lastname: Cummings
authors.forename: Tse-I
authors.initials: TI
authors.lastname: Lin
authors.forename: Lili
authors.initials: L
authors.lastname: Hu
authors.forename: Abdellah
authors.initials: A
authors.lastname: Tahri
authors.forename: David
authors.initials: D
authors.lastname: McGowan
authors.forename: Katie
authors.initials: K
authors.lastname: Amssoms
authors.forename: Stefaan
authors.initials: S
authors.lastname: Last
authors.forename: Benoit
authors.initials: B
authors.lastname: Devogelaere
authors.forename: Marie-Claude
authors.initials: MC
authors.lastname: Rouan
authors.forename: Leen
authors.initials: L
authors.lastname: Vijgen
authors.forename: Jan Martin
authors.initials: JM
authors.lastname: Berke
authors.forename: Pascale
authors.initials: P
authors.lastname: Dehertogh
authors.forename: Els
authors.initials: E
authors.lastname: Fransen
authors.forename: Erna
authors.initials: E
authors.lastname: Cleiren
authors.forename: Liesbet
authors.initials: L
authors.lastname: van der Helm
authors.forename: Gregory
authors.initials: G
authors.lastname: Fanning
authors.forename: Kristof
authors.initials: K
authors.lastname: Van Emelen
authors.forename: Origène
authors.initials: O
authors.lastname: Nyanguile
authors.forename: Kenny
authors.initials: K
authors.lastname: Simmen
authors.forename: Pierre
authors.initials: P
authors.lastname: Raboisson
authors.forename: Sandrine
authors.initials: S
authors.lastname: Vendeville
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001665:Binding Sites; D018360:Crystallography, X-Ray; D003500:Cyclization; D004285:Dogs; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000493:pharmacokinetics*; D016174:Hepacivirus / Q000378:metabolism*; D007211:Indoles / Q000737:chemistry; D008297:Male; D017434:Protein Structure, Tertiary; D051381:Rats; D017207:Rats, Sprague-Dawley; D017361:Viral Nonstructural Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D012324:RNA-Dependent RNA Polymerase
chemical_list: D004791:Enzyme Inhibitors; D007211:Indoles; D017361:Viral Nonstructural Proteins; C030374:indole; C087036:NS-5 protein, hepatitis C virus; D012324:RNA-Dependent RNA Polymerase