title: Proliferation and metabolism: it's as easy as APC.
abstract: Proliferating cells must generate both ATP and biosynthetic precursors for macromolecular synthesis. While proliferative signals have long been known to regulate metabolism, Garedew et al. now demonstrate that the proliferation apparatus itself, in the form of the ubiquitin ligase anaphase-promoting complex/cyclosome (APC/C), directly controls mitochondrial biogenesis, morphology, and respiratory activity.
authors.affiliation: Department of Pathology, University of Utah School of Medicine, Salt Lake City, UT 84112, USA.
authors.forename: Dean
authors.initials: D
authors.lastname: Tantin
authors.forename: Jared
authors.initials: J
authors.lastname: Rutter