title: Mechanism of thyrotoxic periodic paralysis.
abstract: The pathogenesis of thyrotoxic periodic paralysis has long been thought related to increased Na(+)-K(+) ATPase activity stimulated by thyroid hormone and/or hyperadrenergic activity and hyperinsulinemia. This mechanism alone, however, cannot adequately explain how hypokalemia occurs during acute attacks or the associated paradoxical depolarization of the resting membrane potential. Recent findings that loss of function mutations of the skeletal muscle-specific inward rectifying K(+) (Kir) channel, Kir2.6, associate with thyrotoxic periodic paralysis provide new insights into how reduced outward K(+) efflux in skeletal muscle, from either channel mutations or inhibition by hormones (adrenalin or insulin), can lead to a vicious cycle of hypokalemia and paradoxical depolarization, which in turn, inactivates Na(+) channels and causes muscle unexcitability and paralysis.
authors.affiliation: Division of Nephrology, Department of Medicine, Tri-Service General Hospital, No. 325 Section 2 Cheng-Kung Road, Taipei, Taiwan, Republic of China. l521116@ndmctsgh.edu.tw
authors.forename: Shih-Hua
authors.initials: SH
authors.lastname: Lin
authors.forename: Chou-Long
authors.initials: CL
authors.lastname: Huang
mesh_terms: D005260:Female; D006801:Humans; D020514:Hypokalemic Periodic Paralysis / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology*; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D011188:Potassium / Q000627:therapeutic use; D024661:Potassium Channels, Inwardly Rectifying / Q000235:genetics; D011379:Prognosis; D018570:Risk Assessment; D012720:Severity of Illness Index; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013960:Thyroid Function Tests; D013963:Thyroid Hormones / Q000378:metabolism*; D013971:Thyrotoxicosis / Q000503:physiopathology*; D016896:Treatment Outcome; D000098854:Kcnj10 Channel
chemical_list: D000098854:Kcnj10 Channel; D024661:Potassium Channels, Inwardly Rectifying; D013963:Thyroid Hormones; D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium