title: Highly efficient synthesis of a class of novel chiral-bridged atropisomeric monophosphine ligands via simple desymmetrization and their applications in asymmetric Suzuki-Miyaura coupling reaction.
abstract: A series of novel chiral-bridged atropisomeric monophosphine ligands were synthesized via convenient and simple pathways. The prepared ligands, especially for ligand 7d, were found to be highly effective in the Pd-catalyzed Suzuki-Miyaura coupling reaction. The steric hindrance and electronic effect of substrates on the reactivity and enantioselectivity were explored preliminarily.
authors.affiliation: School of Chemistry and Chemical Engineering, Guangdong Engineering Research Center of Chiral Drugs, Sun Yat-Sen University, No. 135 Xingangxi Road, Guangzhou 510275, PR China.
authors.forename: Shouliang
authors.initials: S
authors.lastname: Wang
authors.forename: Jinjin
authors.initials: J
authors.lastname: Li
authors.forename: Tingting
authors.initials: T
authors.lastname: Miao
authors.forename: Wenhao
authors.initials: W
authors.lastname: Wu
authors.forename: Qing
authors.initials: Q
authors.lastname: Li
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhuang
authors.forename: Zhongyuan
authors.initials: Z
authors.lastname: Zhou
authors.forename: Liqin
authors.initials: L
authors.lastname: Qiu
mesh_terms: D002384:Catalysis; D008024:Ligands; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry; D010720:Phosphines / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D008024:Ligands; D010720:Phosphines; D010165:Palladium