title: Pre-diagnostic acrylamide exposure and survival after breast cancer among postmenopausal Danish women.
abstract: Acrylamide is a probable human carcinogen, with industrial contact, tobacco smoking and foods processed at high temperatures as the main routes of exposure. In animal studies oral intake of acrylamide has been related to cancer development, with indications that the increased cancer occurrence especially regards endocrine related tumors. In human epidemiological studies, dietary exposure to acrylamide has also been suggested related to higher risk of endocrine related tumors, like estrogen sensitive breast cancer. The aim of the present study was to evaluate if pre-diagnostic acrylamide exposure, measured by acrylamide and glycidamide hemoglobin adducts (AA-Hb and GA-Hb), were associated to mortality in breast cancer cases. Among 24,697 postmenopausal women included into a Danish cohort between 1993 and 1997, 420 developed breast cancer before 2001 and 110 died before 2009. AA-Hb and GA-Hb concentrations measured in blood samples were related to mortality by Cox proportional hazard models. Estimates are given per 25 pmol/g globin higher levels. Among non-smokers, higher concentrations of GA-Hb were associated to a higher hazard rate of breast cancer specific mortality (HR (95% CI): 1.63 (1.06-2.51)), the hazard rate among women diagnosed with estrogen receptor positive tumors was (HR (95% CI): 2.23 (1.38-3.61)). For AA-Hb the tendency was similar, but only statistically significant among those with estrogen receptor positive tumors (HR (95% CI): 1.31 (1.02-1.69)). In conclusion, the present study indicates that pre-diagnostic exposure to acrylamide may be related to mortality among breast cancer patients and that this may especially concern the most endocrine related type of breast cancer.
authors.affiliation: Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark. anja@cancer.dk
authors.forename: Anja
authors.initials: A
authors.lastname: Olsen
authors.forename: Jane
authors.initials: J
authors.lastname: Christensen
authors.forename: Malene
authors.initials: M
authors.lastname: Outzen
authors.forename: Pelle Thonning
authors.initials: PT
authors.lastname: Olesen
authors.forename: Henrik
authors.initials: H
authors.lastname: Frandsen
authors.forename: Kim
authors.initials: K
authors.lastname: Overvad
authors.forename: Jytte
authors.initials: J
authors.lastname: Halkjær
mesh_terms: D020106:Acrylamide / Q000097:blood*; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000378:metabolism; D003718:Denmark / Q000453:epidemiology; D004781:Environmental Exposure; D004785:Environmental Pollutants / Q000097:blood*; D004852:Epoxy Compounds / Q000097:blood*; D005260:Female; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause / Q000097:blood; D012307:Risk Factors
chemical_list: D015415:Biomarkers; D004785:Environmental Pollutants; D004852:Epoxy Compounds; D006454:Hemoglobins; D020106:Acrylamide; C071834:glycidamide