title: Poly(amidoamine) dendrimer-mediated synthesis and stabilization of silver sulfonamide nanoparticles with increased antibacterial activity.
abstract: Silver sulfadiazine (AgSD) is a topical antibiotic with limited aqueous solubility. In this study, it was shown that poly(amido amine) (PAMAM) dendrimer complexes with SD (SDZ) and silver (Ag) could be used for a bottom-up approach to synthesize highly-soluble AgSD nanoparticles (NPs). These NPs were stabilized against crystal growth by electrostatic layer-by-layer (LBL) coating with various PAMAM dendrimers. Additionally, AgNPs can be incorporated in the dendrimer shells that augmented AgSD release. NP formulation in a cream base provided a topical drug-delivery platform with enhanced antibacterial properties against burn-wound infections, comprising three nanostructures i.e., nano-AgSD, AgNPs as well as PAMAM dendrimers, in one efficient, elegant nanosystem.
  
  
  BACKGROUND
  In this paper an elegant silver sulfadiazine-based nanoparticle complex is demonstrated with enhanced antibacterial properties and improved solubility for the treatment of burn-wound infections in a topical crème formulation.
authors.affiliation: School of Pharmacy, University of Wisconsin-Madison, Madison, WI 53705, USA.
authors.forename: Schalk J
authors.initials: SJ
authors.lastname: Strydom
authors.forename: Warren E
authors.initials: WE
authors.lastname: Rose
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Otto
authors.forename: Wilna
authors.initials: W
authors.lastname: Liebenberg
authors.forename: Melgardt M
authors.initials: MM
authors.lastname: de Villiers
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D050091:Dendrimers / Q000138:chemical synthesis*; D053768:Metal Nanoparticles; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D011073:Polyamines / Q000138:chemical synthesis*; D012834:Silver / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D050091:Dendrimers; C531249:Poly(amidoamine); D011073:Polyamines; D012834:Silver