title: Implantation of orthobiologic, biodegradable scaffolds in osteochondral repair.
abstract: The treatment of articular cartilage lesions is complicated, but novel tissue engineering approaches seem to improve the outcome. A tissue engineering approach is less invasive and reduces surgical time, periosteal hypertrophy, and morbidity. Cell-based therapies using scaffolds have advantages compared with microfracture techniques, but the efficacy and cost-effectiveness need to be investigated. Second-generation cell-based therapies have lower morbidity and the ease of the technique is not significantly different from that of first-generation autologous chondrocyte implantation techniques. Third-generation cell-based therapies such as the use of tissue engineered scaffolds need to be studied in more detail.
authors.affiliation: Division of Paediatric Orthopaedics, National University Hospital, 5, Lower Kent Ridge Road, Kent Ridge Wing 2, Level 3, 119074, Singapore. James_hui@nuhs.edu.sg
authors.forename: James H P
authors.initials: JH
authors.lastname: Hui
authors.forename: Kizher S
authors.initials: KS
authors.lastname: Buhary
authors.forename: Ashwin
authors.initials: A
authors.lastname: Chowdhary
mesh_terms: D020341:Absorbable Implants; D054544:Arthroplasty, Subchondral / Q000191:economics / Q000379:methods; D002358:Cartilage, Articular / Q000473:pathology / Q000601:surgery*; D019902:Chondrocytes / Q000637:transplantation*; D005260:Female; D006801:Humans; D007719:Knee Joint / Q000473:pathology / Q000601:surgery*; D008297:Male; D019637:Orthopedic Procedures / Q000191:economics / Q000379:methods*; D010007:Osteochondritis / Q000473:pathology / Q000601:surgery; D010147:Pain Measurement; D020127:Recovery of Function; D018570:Risk Assessment; D023822:Tissue Engineering / Q000379:methods; D054457:Tissue Scaffolds; D014182:Transplantation, Autologous; D016896:Treatment Outcome