title: Optimization of self-assembling properties of fatty acids grafted to methoxy poly(ethylene glycol) as nanocarriers for etoposide.
abstract: The objective of this work was to study the effect of fatty acid chain length grafted to methoxy poly(ethylene glycol) (mPEG) on self assembling properties of micelles for etoposide delivery. Three amphiphilic copolymers were synthesized using mPEG, myristic acid, stearic acid and behenic acid through an esteric linkage. The particle size and zeta potential of the micelles were determined by the dynamic light scattering method. Etoposide was loaded into micelles by film casting using various drug/polymer ratios. Drug release was studied by the dialysis method. The structure of copolymers was confirmed by (1)H NMR and FTIR. Central micellar concentration (CMC) measurements showed that the longer hydrophobic chains formed more thermodynamically stable micelles. Among the prepared copolymers, etoposide showed the highest solubility in the mPEG-behenic copolymer. Drug loading efficiency depended on the hydrophobic chain length and drug/polymer ratio. The highest drug loading efficiency was found in mPEG-myristic micelles with 1:20 drug/polymer ratio. Micelles released 80 % of loaded drug within about 5 h.
authors.affiliation: Department of Pharmaceutics, Faculty of Pharmacy and Isfahan, Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Iran. varshosaz@pharm.mui.ac.ir
authors.forename: Jaleh
authors.initials: J
authors.lastname: Varshosaz
authors.forename: Farshid
authors.initials: F
authors.lastname: Hasanzadeh
authors.forename: Mojtaba
authors.initials: M
authors.lastname: Eslamdoost
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D003956:Dialysis; D004337:Drug Carriers; D004339:Drug Compounding; D005047:Etoposide / Q000737:chemistry*; D005227:Fatty Acids / Q000737:chemistry*; D057927:Hydrophobic and Hydrophilic Interactions; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D008823:Micelles; D019814:Myristic Acid / Q000737:chemistry; D053758:Nanoparticles; D036103:Nanotechnology; D010316:Particle Size; D011092:Polyethylene Glycols / Q000737:chemistry*; D012995:Solubility; D012997:Solvents / Q000737:chemistry; D017550:Spectroscopy, Fourier Transform Infrared; D013229:Stearic Acids / Q000737:chemistry; D013678:Technology, Pharmaceutical / Q000379:methods; D014867:Water / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004337:Drug Carriers; D005227:Fatty Acids; D008823:Micelles; D012997:Solvents; D013229:Stearic Acids; D014867:Water; D019814:Myristic Acid; D011092:Polyethylene Glycols; C031183:stearic acid; D005047:Etoposide; C028210:monomethoxypolyethylene glycol; C007547:behenic acid