title: [Risk factors for anastomotic leakage following colorectal resection for cancer].
abstract: OBJECTIVE
  To identify the risk and prognosis factors and their predictive value for anastomotic leakage after colorectal resections following cancer.
  
  
  METHODS
  1743 consecutive patients who underwent colic resections or rectal resections for colo-rectal cancer between 1996-2005 in Surgical Clinic no. 3 (Cluj-Napoca, Romania) were retrospectively analysed.
  
  
  RESULTS
  A total of 54 (3.09 percent) anastomotic leaks were confirmed. Univariate analisys showed that the preoperative variables significantly associated with anastomotic leakage included weight loss, smoking, cardiovascular disease, lung disease, hypoproteinemia, diabetes, anemia, leukocitosis, presence of two or more underlying diseases. Use of alcohol, cerebrovascular disease, bowel preparation, mode of antibiotic prophylaxis, type of handsewn anastomosis, tumor location, tumor stage and tumor histology were nonsignificant variables. Hipoproteniemia (S - proteins < 60g/dl) and anemia (S Hb < 11) remained significant in logistic regression model.
  
  
  CONCLUSIONS
  Our study shows that a value of S-proteins lower than 60 g/l and s-Hb lower than 99 g/l can be consider as predictive marker for anastomotik leak deshiscence.
authors.affiliation: Clinica Chirurgie III, Universitatea de Medicină si Farmacie "Iuliu Haţieganu", Cluj-Napoca, România.
authors.forename: F
authors.initials: F
authors.lastname: Zaharie
authors.forename: L
authors.initials: L
authors.lastname: Mocan
authors.forename: C
authors.initials: C
authors.lastname: Tomuş
authors.forename: T
authors.initials: T
authors.lastname: Mocan
authors.forename: R
authors.initials: R
authors.lastname: Zaharie
authors.forename: D
authors.initials: D
authors.lastname: Bartoş
authors.forename: A
authors.initials: A
authors.lastname: Bartoş
authors.forename: L
authors.initials: L
authors.lastname: Vlad
authors.forename: C
authors.initials: C
authors.lastname: Iancu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D057868:Anastomotic Leak / Q000209:etiology*; D014408:Biomarkers, Tumor / Q000097:blood*; D003082:Colectomy / Q000009:adverse effects*; D015179:Colorectal Neoplasms / Q000097:blood / Q000473:pathology / Q000601:surgery*; D013505:Digestive System Surgical Procedures; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D011379:Prognosis; D017293:Protein S / Q000378:metabolism; D012189:Retrospective Studies; D012307:Risk Factors; D012680:Sensitivity and Specificity; D013529:Surgical Wound Dehiscence / Q000209:etiology* / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor; D006454:Hemoglobins; D017293:Protein S