title: New perspectives on endothelin-1 in atherosclerosis and diabetes mellitus.
abstract: Endothelin-1 (ET-1) is a vasoconstrictor, proinflammatory and proliferative endothelial cell-derived peptide that is of significant importance in the regulation of vascular function. It is involved in the development of endothelial dysfunction including important interactions with nitric oxide. The expression and functional effects of ET-1 and its receptors are markedly altered during development of cardiovascular disease. Increased production of ET-1 and its receptors mediate many pathophysiological events contributing to the development of atherosclerosis and vascular complications in diabetes mellitus. The present review focuses on the pathophysiological role of ET-1 and the potential importance of ET receptors as a therapeutic target for treatment of these conditions.
authors.affiliation: Karolinska Institutet, Cardiology Unit, Department of Medicine, Karolinska University Hospital, 171 76 Stockholm, Sweden. john.pernow@ki.se
authors.forename: John
authors.initials: J
authors.lastname: Pernow
authors.forename: Alexey
authors.initials: A
authors.lastname: Shemyakin
authors.forename: Felix
authors.initials: F
authors.lastname: Böhm
mesh_terms: D000818:Animals; D001161:Arteriosclerosis / Q000188:drug therapy* / Q000503:physiopathology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D019332:Endothelin-1 / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000502:physiology / Q000503:physiopathology; D006801:Humans; D009569:Nitric Oxide / Q000378:metabolism; D017466:Receptors, Endothelin / Q000378:metabolism; D014661:Vasoconstriction
chemical_list: D019332:Endothelin-1; D017466:Receptors, Endothelin; D009569:Nitric Oxide