title: Increased axonal expression of nectin-1 in multiple sclerosis plaques.
abstract: Nectin-1 is a cell adhesion molecule that plays a role in interneuronal synapse formation, in axonal guidance during development and possibly in neuron-glia interactions. To better understand axonal changes in MS, nectin-1 expression was determined by immunohistochemistry in normal adult human cerebral white matter (n = 4) and in six MS plaques (three active and three inactive). The intensity of axonal nectin-1 expression was scored on a scale of 0 to 4+. In normal adult cerebral white matter, axons showed weak nectin-1 expression with a score of 1.25 ± 0.50. Axonal nectin-1 expression was significantly stronger within both active (score = 3.33 ± 0.289, p = 0.001) and inactive (score = 2.16 ± 0.29, p = 0.038) MS plaques than in normal white matter. Axons in white matter adjacent to MS plaques showed nectin-1 expression (score = 1.5 ± 0.50) that was not statistically different from normal controls (p = 0.542). These findings raise the possibility that increased expression of nectin-1 in MS lesions plays a role in the pathogenesis of MS through participation in axonal responses to injury and mediation of altered neuron-glia interactions relevant to myelination.
authors.affiliation: Department of Pathology, University of Illinois at Chicago, College of Medicine, Chicago, IL, USA.
authors.forename: Karla J
authors.initials: KJ
authors.lastname: Castellanos
authors.forename: Eva
authors.initials: E
authors.lastname: Gagyi
authors.forename: Bernadett
authors.initials: B
authors.lastname: Kormos
authors.forename: Klara
authors.initials: K
authors.lastname: Valyi-Nagy
authors.forename: Andras
authors.initials: A
authors.lastname: Voros
authors.forename: Deepak
authors.initials: D
authors.lastname: Shukla
authors.forename: Szatmar
authors.initials: S
authors.lastname: Horvath
authors.forename: Konstantin V
authors.initials: KV
authors.lastname: Slavin
authors.forename: Tibor
authors.initials: T
authors.lastname: Valyi-Nagy
mesh_terms: D015703:Antigens, CD / Q000378:metabolism; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006801:Humans; D008297:Male; D009103:Multiple Sclerosis / Q000378:metabolism* / Q000473:pathology*; D000075983:Nectins; D016900:Neurofilament Proteins / Q000378:metabolism; D058225:Plaque, Amyloid / Q000473:pathology*; D015854:Up-Regulation / Q000502:physiology; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D015815:Cell Adhesion Molecules; D005904:Glial Fibrillary Acidic Protein; D000075983:Nectins; D016900:Neurofilament Proteins; C067980:CD68 antigen, human; D000097382:CD68 Molecule; C000619010:NECTIN1 protein, human