title: Advances in the chemoprevention of non-melanoma skin cancer in high-risk organ transplant recipients.
abstract: Patients with a history of more than four basal cell carcinomas (BCCs) or squamous cell carcinomas (SCCs) are at high risk for developing further skin cancers. Immunosuppressed patients, especially solid organ transplantation patients, harbor a higher risk of developing SCC. Systemic retinoids have been demonstrated to possess chemoprophylactic properties in the treatment of non-melanoma skin cancer. This article reviews the efficacies of the available oral retinoid agents in the chemoprophylaxis of SCCs in high-risk solid organ transplant recipients.
authors.affiliation: University of South Florida College of Medicine, Department of Dermatology and Cutaneous Surgery, Tampa, FL 33612, USA. mlien@health.usf.edu
authors.forename: Mary H
authors.initials: MH
authors.lastname: Lien
authors.forename: Neil Alan
authors.initials: NA
authors.lastname: Fenske
authors.forename: L Frank
authors.initials: LF
authors.lastname: Glass
mesh_terms: D000818:Animals; D002280:Basal Cell Carcinoma / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control*; D018890:Chemoprevention / Q000379:methods; D004311:Double-Blind Method; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D012176:Retinoids / Q000627:therapeutic use*; D012307:Risk Factors; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control*; D014180:Transplantation
chemical_list: D012176:Retinoids