title: Management of asthma in children with long QT syndrome.
abstract: The Long QT syndrome (LQTS) is a rare disorder in which patients are prone to life threatening ventricular arrhythmia and is a leading cause of sudden death in childhood. Asthma is common and its management in those with LQTS presents a number of potential difficulties. The mainstay of therapy in LQTS is beta-blockade, which may worsen symptoms of asthma. Conversely, beta-agonist therapy is the mainstay of asthma management; which, in those with LQTS, may provoke ventricular arrhythmias. We review available data regarding the management of coexistent LQTS and asthma, and provide a summary of the necessary considerations in managing these patients.
authors.affiliation: Department Respiratory Paediatrics, Royal Children's Hospital, 50 Flemington Road, Melbourne, Victoria, 3052, Australia. samacollins@gmail.com
authors.forename: Samuel
authors.initials: S
authors.lastname: Collins
authors.forename: John
authors.initials: J
authors.lastname: Widger
authors.forename: Andrew
authors.initials: A
authors.lastname: Davis
authors.forename: John
authors.initials: J
authors.lastname: Massie
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000318:Adrenergic beta-Agonists / Q000627:therapeutic use*; D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000209:etiology*; D001249:Asthma / Q000150:complications / Q000188:drug therapy*; D002648:Child; D018680:Cholinergic Antagonists / Q000627:therapeutic use*; D016757:Death, Sudden, Cardiac / Q000209:etiology; D006801:Humans; D008133:Long QT Syndrome / Q000150:complications / Q000188:drug therapy*
chemical_list: D000305:Adrenal Cortex Hormones; D000318:Adrenergic beta-Agonists; D000319:Adrenergic beta-Antagonists; D018680:Cholinergic Antagonists