title: Synthesis and biological evaluation of truncated α-galactosylceramide derivatives focusing on cytokine induction profile.
abstract: A series of truncated analogs of α-galactosylceramide with altered ceramide moiety was prepared, and evaluated for Th2-biased response in the context of IL-4/IFN-γ ratio. Phytosphingosine-modified analogs including cyclic, aromatic and ethereal compounds as well as the C-glycoside analog of OCH (2) with their cytokine inducing profile are disclosed.
authors.affiliation: Asubio Pharma Co., Ltd, 6-4-3, Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan.
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Toba
authors.forename: Kenji
authors.initials: K
authors.lastname: Murata
authors.forename: Junko
authors.initials: J
authors.lastname: Futamura
authors.forename: Kyoko
authors.initials: K
authors.lastname: Nakanishi
authors.forename: Bitoku
authors.initials: B
authors.lastname: Takahashi
authors.forename: Naohiro
authors.initials: N
authors.lastname: Takemoto
authors.forename: Minako
authors.initials: M
authors.lastname: Tomino
authors.forename: Takashi
authors.initials: T
authors.lastname: Nakatsuka
authors.forename: Seiichi
authors.initials: S
authors.lastname: Imajo
authors.forename: Megumi
authors.initials: M
authors.lastname: Goto
authors.forename: Takashi
authors.initials: T
authors.lastname: Yamamura
authors.forename: Sachiko
authors.initials: S
authors.lastname: Miyake
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Annoura
mesh_terms: D000818:Animals; D055610:Antigens, CD1d / Q000737:chemistry / Q000378:metabolism; D001665:Binding Sites; D003198:Computer Simulation; D005699:Galactosylceramides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D005786:Gene Expression Regulation / Q000187:drug effects*; D007371:Interferon-gamma / Q000378:metabolism*; D015847:Interleukin-4 / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D018418:Th2 Cells / Q000187:drug effects
chemical_list: D055610:Antigens, CD1d; D005699:Galactosylceramides; C493154:alpha-galactosylceramide; D015847:Interleukin-4; D007371:Interferon-gamma