title: A new cytotoxic lymphocyte-defined antigen coded by a gene closely linked to the H-3 locus.
abstract: F1 complementation results indicate that a new gene, putatively controlling a minor histocompatibility antigen, is closely linked to the minor histocompatibility gene, H-3, in the fifth linkage group of chromosome 2 of the mouse. This gene controls a product that was capable of inducing as well as acting as a target for cytotoxic lymphocytes (CTL). The lytic activity of CTL developed in B10.LP-H-3D mice specific for the product of the new gene of B10 was restricted to target cells possessing H-2Db antigens. This contrasts to the H-2Kb-restricted activity of H-3.1 specific CTL.
authors.affiliation: Department of Microbiology, University of Minnesota, Minneapolis, Minnesota 55455, USA.
authors.forename: D C
authors.initials: DC
authors.lastname: Roopenian
authors.forename: R E
authors.initials: RE
authors.lastname: Click
mesh_terms: D000818:Animals; D000918:Antibody Specificity / Q000276:immunology; D003429:Cross Reactions / Q000276:immunology; D008040:Genetic Linkage; D006183:H-2 Antigens / Q000235:genetics / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D015778:Minor Histocompatibility Antigens / Q000235:genetics* / Q000276:immunology*; D008912:Minor Histocompatibility Loci / Q000235:genetics* / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014184:Transplantation, Homologous
chemical_list: D006183:H-2 Antigens; D015778:Minor Histocompatibility Antigens