title: Identification of porcine rotavirus-like genotype P[6] strains in Taiwanese children.
abstract: The molecular characterization of genotype P[6] rotavirus strains collected from children admitted to hospital with acute dehydrating diarrhoea during a 6-year surveillance period in Taiwan is described in this study. In total, three G4P[6] strains, one G5P[6] and one G12P[6] were characterized by sequencing and phylogenetic analysis of the VP4, VP7, VP6 and NSP4 genes. Whilst all four genes of the single Taiwanese G12P[6] strain clustered with the respective genes of globally common human rotavirus strains, the G4 and G5 strains showed remarkable similarities to porcine rotavirus strains and putative porcine-origin human P[19] strains reported previously from Taiwan. The overall proportion of porcine rotavirus-like strains in Taiwan remains around 1 % among hospitalized children; however, the circulation and sporadic transmission of these heterotypic strains from pigs to humans could pose a public-health concern. Therefore, continuation of strain monitoring is needed in the vaccine era to detect any possible vaccine breakthrough events associated with the introduction of such heterologous rotavirus strains.
authors.affiliation: Division of Pediatric Infectious Disease, Department of Pediatrics, China Medical University Hospital, China Medical University School of Medicine, Taichung, Taiwan ROC.
authors.forename: Kao-Pin
authors.initials: KP
authors.lastname: Hwang
authors.affiliation: Department of Biotechnology and Laboratory Science in Medicine, National Yang-Ming University, Taipei, Taiwan ROC.|Centers for Disease Control, Department of Health, Taiwan ROC.
authors.forename: Fang-Tzy
authors.initials: FT
authors.lastname: Wu
authors.affiliation: Veterinary Medical Research Institute, Budapest, Hungary.
authors.forename: Krisztián
authors.initials: K
authors.lastname: Bányai
authors.affiliation: School of Medical Laboratory Science and Biotechnology, Taipei Medical University, Taipei, Taiwan ROC.|Centers for Disease Control, Department of Health, Taiwan ROC.
authors.forename: Ho-Sheng
authors.initials: HS
authors.lastname: Wu
authors.affiliation: Centers for Disease Control, Department of Health, Taiwan ROC.
authors.forename: Dustin Chen-Fu
authors.initials: DC
authors.lastname: Yang
authors.affiliation: Division of Pediatric Infectious Disease, Chang Gung Children's Hospital, Chang Gung University College of Medicine, Taoyuan, Taiwan ROC.
authors.forename: Yhu-Chering
authors.initials: YC
authors.lastname: Huang
authors.affiliation: Department of Laboratory Medicine, Changhua Christian Hospital, Changhua, Taiwan ROC.
authors.forename: Jen-Shiou
authors.initials: JS
authors.lastname: Lin
authors.affiliation: Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan ROC.
authors.forename: Chao Agnes
authors.initials: CA
authors.lastname: Hsiung
authors.affiliation: Department of Biotechnology and Laboratory Science in Medicine, National Yang-Ming University, Taipei, Taiwan ROC.
authors.forename: Jason C
authors.initials: JC
authors.lastname: Huang
authors.affiliation: Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
authors.forename: Baoming
authors.initials: B
authors.lastname: Jiang
authors.affiliation: Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA, USA.
authors.forename: Jon R
authors.initials: JR
authors.lastname: Gentsch
mesh_terms: D000818:Animals; D002675:Child, Preschool; D016000:Cluster Analysis; D003967:Diarrhea / Q000821:virology*; D005759:Gastroenteritis / Q000821:virology*; D005838:Genotype; D006761:Hospitals; D006801:Humans; D012367:RNA, Viral / Q000235:genetics; D012401:Rotavirus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D012400:Rotavirus Infections / Q000821:virology*; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D013552:Swine; D013553:Swine Diseases / Q000821:virology; D013624:Taiwan; D014764:Viral Proteins / Q000235:genetics; D015047:Zoonoses / Q000821:virology
chemical_list: D012367:RNA, Viral; D014764:Viral Proteins