title: Clinical practice recommendations for the treatment of Alport syndrome: a statement of the Alport Syndrome Research Collaborative.
abstract: We present clinical practice recommendations for the treatment of children with Alport syndrome who are not enrolled in clinical trials. Our goal is to promote early initiation of a standard therapeutic approach that will facilitate assessment of the safety and efficacy of the protocol. The treatment protocol is based on the reduction of proteinuria, intraglomerular pressure, and renal fibrosis via interference with the renin-angiotensin-aldosterone system.
authors.affiliation: Department of Pediatrics, Division of Pediatric Nephrology, University of Minnesota Medical School, Minneapolis, MN, USA. kasht001@umn.edu
authors.forename: Clifford E
authors.initials: CE
authors.lastname: Kashtan
authors.forename: Jie
authors.initials: J
authors.lastname: Ding
authors.forename: Martin
authors.initials: M
authors.lastname: Gregory
authors.forename: Oliver
authors.initials: O
authors.lastname: Gross
authors.forename: Laurence
authors.initials: L
authors.lastname: Heidet
authors.forename: Bertrand
authors.initials: B
authors.lastname: Knebelmann
authors.forename: Michelle
authors.initials: M
authors.lastname: Rheault
authors.forename: Christoph
authors.initials: C
authors.lastname: Licht
mesh_terms: D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D009394:Nephritis, Hereditary / Q000188:drug therapy* / Q000235:genetics / Q000503:physiopathology