title: Steady-state pharmacokinetics of lopinavir plus ritonavir when administered under different meal conditions in HIV-infected Ugandan adults.
abstract: We investigated the effect of food on the steady-state pharmacokinetics of lopinavir and ritonavir in 12 Ugandan patients receiving lopinavir coformulated with ritonavir (LPV/r) tablets using a crossover design. Intensive pharmacokinetic sampling was performed 7 days apart after LPV/r dosing under moderate fat, high fat, and fasted meal conditions. Lopinavir and ritonavir concentrations were determined by liquid chromatography and tandem mass spectrometry. Compared with the fasted state, a high fat meal reduced lopinavir and ritonavir area under the curve by 14% and 29%, respectively. With a moderate fat meal, area under the curve for both drugs was similar to the fasted state.
authors.affiliation: Research Department, Infectious Diseases Institute, Makerere University College of Health Sciences, Kampala, Uganda. mlamorde@idi.co.ug
authors.forename: Mohammed
authors.initials: M
authors.lastname: Lamorde
authors.forename: Pauline
authors.initials: P
authors.lastname: Byakika-Kibwika
authors.forename: Marta
authors.initials: M
authors.lastname: Boffito
authors.forename: Lillian
authors.initials: L
authors.lastname: Nabukeera
authors.forename: Jonathan
authors.initials: J
authors.lastname: Mayito
authors.forename: Jasper
authors.initials: J
authors.lastname: Ogwal-Okeng
authors.forename: John
authors.initials: J
authors.lastname: Tjia
authors.forename: David
authors.initials: D
authors.lastname: Back
authors.forename: Saye
authors.initials: S
authors.lastname: Khoo
authors.forename: Mairin
authors.initials: M
authors.lastname: Ryan
authors.forename: Concepta
authors.initials: C
authors.lastname: Merry
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D018592:Cross-Over Studies; D004041:Dietary Fats / Q000008:administration & dosage; D004334:Drug Administration Schedule; D004435:Eating; D005215:Fasting; D005260:Female; D015658:HIV Infections / Q000097:blood* / Q000188:drug therapy*; D006801:Humans; D061466:Lopinavir / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D008875:Middle Aged; D019438:Ritonavir / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*; D014454:Uganda
chemical_list: D019380:Anti-HIV Agents; D004041:Dietary Fats; D061466:Lopinavir; D019438:Ritonavir