title: Management of hypertension and factors affecting its control in Jordanian renal transplant recipients.
abstract: BACKGROUND
  Hypertension affects 70-90 % of all kidney transplant recipients. It is associated with poor graft survival and is a contributing factor to the increased cardiovascular mortality. The reasons for the insufficient blood pressure control in transplanted patients have not been thoroughly investigated.
  
  
  OBJECTIVE
  To evaluate the extent of blood pressure control in Jordanian hypertensive renal transplant recipients and to assess factors associated with such control.
  
  
  METHODS
  Three outpatient renal transplant clinics in Amman.
  
  
  METHODS
  A cross-sectional observational study including 181 patients. We have considered blood pressure <130/80 mm Hg as controlled hypertension. Bivariate and multivariate logistic regression analyses were used to determine clinical factors associated with achievement of blood pressure control.
  
  
  METHODS
  Proportion of patients who achieved hypertension control and clinical factors associated with good blood pressure control.
  
  
  RESULTS
  Mean systolic blood pressure was 128.6 ± 16.3 mm Hg and mean diastolic blood pressure was 82.8 ± 11.5 mm Hg. Blood pressure control was achieved only in 58 % of patients. The most commonly prescribed antihypertensives were calcium channel blockers (58 %) followed by beta-blockers (44 %). In bivariate analysis, female gender (p = 0.017) and creatinine clearance (p = 0.002) were positively associated, while number of antihypertensive medications was inversely associated (p = 0.04) with achievement of blood pressure control. After including these factors in multivariate logistic regression analysis, only creatinine clearance remained independently associated with hypertension control (odds ratio, OR 1.04; 95 % confidence interval [CI] 1.01-1.06; p = 0.003).
  
  
  CONCLUSIONS
  Blood pressure control among renal transplant recipients in Jordan was found to be inadequate. The only factor found to be independently associated with adequate blood pressure control was creatinine clearance.
authors.affiliation: Department of Biopharmaceutics and Clinical Pharmacy, Faculty of Pharmacy, University of Jordan, PO Box 11942, Amman, Jordan. nyounes@ju.edu.jo
authors.forename: Nailya
authors.initials: N
authors.lastname: Bulatova
authors.forename: Al-Motassem
authors.initials: AM
authors.lastname: Yousef
authors.forename: Hisham
authors.initials: H
authors.lastname: Qusa
authors.forename: Ghada Al
authors.initials: GA
authors.lastname: Khayat
authors.forename: Wadad
authors.initials: W
authors.lastname: Ailabouni
authors.forename: Ayman
authors.initials: A
authors.lastname: Wahbeh
authors.forename: Muhammad
authors.initials: M
authors.lastname: Al-Ulemat
mesh_terms: D000293:Adolescent; D000328:Adult; D000959:Antihypertensive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D003430:Cross-Sectional Studies; D019468:Disease Management; D005260:Female; D006085:Graft Survival / Q000187:drug effects / Q000502:physiology; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000453:epidemiology* / Q000503:physiopathology; D007597:Jordan / Q000453:epidemiology; D016030:Kidney Transplantation / Q000009:adverse effects* / Q000502:physiology; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D000959:Antihypertensive Agents