title: [Association between rs6658835 polymorphism of transforming growth factor beta 2 gene and congenital heart diseases in Chinese Han population].
abstract: OBJECTIVE
  To assess the association between a tag single nucleotide polymorphism (rs6658835) of transforming growth factor beta 2 (TGF beta2) gene and congenital heart disease (CHD) in Chinese Han population.
  
  
  METHODS
  A total of 324 CHD cases including 144 atrial septal defects (ASD), 88 patent ductus arteriosus (PDA), 92 ventricular septal defects (VSD) and 158 healthy controls were enrolled. The genotype of rs6658835 was determined by polymerase chain reaction-restriction fragment length polymorphism assay.
  
  
  RESULTS
  The genotypic and allelic frequencies of rs6658835 were associated with VSD (P< 0.05), but not with ASD or PDA (P> 0.05).
  
  
  CONCLUSIONS
  The rs6658835 polymorphism of TGF beta 2 gene is associated with the susceptibility of VSD in Chinese Han population.
authors.affiliation: Department of Cardiology, Sichuan University, Chengdu, Sichuan, People's Republic of China.
authors.forename: Jun
authors.initials: J
authors.lastname: Xie
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.forename: Hui
authors.initials: H
authors.lastname: Li
authors.forename: Bin
authors.initials: B
authors.lastname: Zhou
authors.forename: Li
authors.initials: L
authors.lastname: Rao
mesh_terms: D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000235:genetics; D002648:Child; D005260:Female; D020022:Genetic Predisposition to Disease; D006330:Heart Defects, Congenital / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D053781:Transforming Growth Factor beta2 / Q000235:genetics*; D055815:Young Adult
chemical_list: D053781:Transforming Growth Factor beta2