title: Apolipoproteins a-I and B as components of metabolic syndrome with respect to diabetes status: a factor analysis.
abstract: BACKGROUND
  The aim of the current study was to elucidate the clustering pattern of metabolic syndrome components along with apolipoproteins (Apo) A-I and B in diabetic and nondiabetic subjects.
  
  
  METHODS
  Factor analysis of conventional variables of metabolic syndrome [i.e., waist circumference, homeostasis model assessment of insulin resistance (HOMA-IR), triglycerides (TG), high-density lipoprotein-cholesterol (HDL-C), and systolic blood pressure (SBP)] with or without addition of Apo A-I and B was performed on 567 and 327 diabetic and nondiabetic subjects, respectively. Thereafter, analyses were repeated after substitution of TG and HDL-C by the TG-to-HDL-C ratio (TG/HDL-C).
  
  
  RESULTS
  Regarding conventional variables of metabolic syndrome, one or two underlying factors were identified, depending on whether lipid measures were entered as two distinct variables or as a composite measure. Apolipoproteins were consistent with a one-factor structure model of metabolic syndrome and did not change the loading pattern remarkably in nondiabetics. TG and HDL-C tended to cluster with Apo B and A-I, respectively, in different models.
  
  
  CONCLUSIONS
  The current study confirms that addition of Apo A-I and B is consistent with the one-factor model of metabolic syndrome and does not modify the loading pattern remarkably in nondiabetic subjects.
authors.affiliation: Endocrinology and Metabolism Research Center, Vali-Asr Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. esteghamati@tums.ac.ir
authors.forename: Alireza
authors.initials: A
authors.lastname: Esteghamati
authors.forename: Ali
authors.initials: A
authors.lastname: Zandieh
authors.forename: Abdoulreza
authors.initials: A
authors.lastname: Esteghamati
authors.forename: Mohammad Salehi
authors.initials: MS
authors.lastname: Sadaghiani
authors.forename: Basira
authors.initials: B
authors.lastname: Zandieh
authors.forename: Elham
authors.initials: E
authors.lastname: Rezaeitabar
authors.forename: Manouchehr
authors.initials: M
authors.lastname: Nakhjavani
mesh_terms: D000328:Adult; D000368:Aged; D000886:Anthropometry / Q000379:methods; D016632:Apolipoprotein A-I / Q000378:metabolism*; D001055:Apolipoproteins B / Q000378:metabolism*; D001794:Blood Pressure; D008076:Cholesterol, HDL / Q000378:metabolism; D003920:Diabetes Mellitus / Q000378:metabolism*; D005163:Factor Analysis, Statistical; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008055:Lipids / Q000737:chemistry; D008297:Male; D024821:Metabolic Syndrome / Q000378:metabolism*; D008875:Middle Aged; D014280:Triglycerides / Q000378:metabolism
chemical_list: D016632:Apolipoprotein A-I; D001055:Apolipoproteins B; D008076:Cholesterol, HDL; D008055:Lipids; D014280:Triglycerides