title: Tyrosine kinase signaling and the emergence of multicellularity.
abstract: Tyrosine phosphorylation is an essential element of signal transduction in multicellular animals. Although tyrosine kinases were originally regarded as specific to the metazoan lineage, it is now clear that they evolved prior to the split between unicellular and multicellular eukaryotes (≈600million years ago). Genome analyses of choanoflagellates and other protists show an abundance of tyrosine kinases that rivals the most complex animals. Some of these kinases are orthologs of metazoan enzymes (e.g., Src), but others display unique domain compositions not seen in any metazoan. Biochemical experiments have highlighted similarities and differences between the unicellular and multicellular tyrosine kinases. In particular, it appears that the complex systems of kinase autoregulation may have evolved later in the metazoan lineage.
authors.affiliation: Department of Physiology and Biophysics, School of Medcine, Stony Brook University, Stony Brook, NY 11794-8661, USA. todd.miller@stonybrook.edu
authors.forename: W Todd
authors.initials: WT
authors.lastname: Miller
mesh_terms: D000818:Animals; D002477:Cells / Q000201:enzymology*; D006801:Humans; D008954:Models, Biological; D010766:Phosphorylation; D017434:Protein Structure, Tertiary; D011505:Protein-Tyrosine Kinases / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D011505:Protein-Tyrosine Kinases