title: Increased prospective memory interference in normal and pathological aging: different roles of motor and verbal processing speed.
abstract: This is a study on prospective memory (PM) and the PM interference effect in normal and pathological aging. One hundred and seven subjects, including 41 healthy young adults, 40 non-demented older adults and 26 patients with mild Alzheimer's disease (AD) participated in this study using a laboratory event-based PM task. PM task performance was comparable between the non-demented older and young adults, but impaired in the AD patients. The PM interference effect increased progressively from the healthy young adults, the non-demented older adults, to the AD patients. Path analysis revealed that the possible mechanism mediating the increased PM interference was the slow motor processing speed in normal aging, while it was the slow verbal speed in pathological aging. It is suggested that different neuropsychological mechanisms may underpin the affected performance of PM task in normal and pathological aging.
authors.affiliation: Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong.
authors.forename: J L
authors.initials: JL
authors.lastname: Gao
authors.forename: R T F
authors.initials: RT
authors.lastname: Cheung
authors.forename: Y S
authors.initials: YS
authors.lastname: Chan
authors.forename: L W
authors.initials: LW
authors.lastname: Chu
authors.forename: T M C
authors.initials: TM
authors.lastname: Lee
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D000544:Alzheimer Disease / Q000150:complications*; D000704:Analysis of Variance; D003210:Concept Formation / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D061212:Memory, Episodic; D008960:Models, Psychological; D009483:Neuropsychological Tests; D011597:Psychomotor Performance / Q000502:physiology*; D011930:Reaction Time; D012044:Regression Analysis; D014705:Verbal Behavior / Q000502:physiology*; D055815:Young Adult