title: Selective turn-on fluorescent probes for imaging hydrogen sulfide in living cells.
abstract: Hydrogen sulfide (H(2)S) is an important biological messenger but few biologically-compatible methods are available for its detection. Here we report two bright fluorescent probes that are selective for H(2)S over cysteine, glutathione and other reactive sulfur, nitrogen, and oxygen species. Both probes are demonstrated to detect H(2)S in live cells.
authors.affiliation: Department of Chemistry, University of Oregon, 1253 University of Oregon, Eugene, OR 97403, USA.
authors.forename: Leticia A
authors.initials: LA
authors.lastname: Montoya
authors.forename: Michael D
authors.initials: MD
authors.lastname: Pluth
mesh_terms: D003545:Cysteine / Q000737:chemistry; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D005978:Glutathione / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D006862:Hydrogen Sulfide / Q000032:analysis*; D015394:Molecular Structure; D053644:Naphthalimides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D005456:Fluorescent Dyes; D053644:Naphthalimides; D005978:Glutathione; D003545:Cysteine; D006862:Hydrogen Sulfide