title: IRIS: the unfortunate rainbow of HIV.
abstract: In this issue of Blood, Mahnke and colleagues identify polyfunctional CD4(+) T-cell responses directed against specific opportunistic pathogens in HIV-infected patients who develop immune reconstitution inflammatory syndrome (IRIS) after initiation of antiretroviral therapy (ART). This work provides a mechanistic advance to our understanding of IRIS pathogenesis.
authors.affiliation: Emory University.
authors.forename: Ann
authors.initials: A
authors.lastname: Chahroudi
authors.forename: Guido
authors.initials: G
authors.lastname: Silvestri
mesh_terms: D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D049109:Cell Proliferation; D005260:Female; D015658:HIV Infections / Q000276:immunology*; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000276:immunology*; D008297:Male