title: Progressive multiple cranial nerve palsies as the presenting symptom of meningeal carcinomatosis from occult colon adenocarcinoma.
abstract: We herein describe a rare case of meningeal carcinomatosis in a 77-year-old woman who had bilateral deafness as the initial symptom of a previously undetected colon cancer malignancy. Meningeal carcinomatosis should be considered in the differential diagnosis in cases of abrupt-onset sensorineural deafness. Both MRI scans and cerebrospinal fluid evaluation are necessary diagnostic tools, and should be used in conjunction as each of these procedures could have false-negative results. This should apply even when there is no known primary malignancy.
authors.affiliation: Department of Neurology and Cerebrovascular Medicine, Saitama International Medical Center, Saitama Medical University, Japan. yujik@saitama-med.ac.jp
authors.forename: Yuji
authors.initials: Y
authors.lastname: Kato
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Takeda
authors.forename: Tomohisa
authors.initials: T
authors.lastname: Dembo
authors.forename: Takuya
authors.initials: T
authors.lastname: Fukuoka
authors.forename: Norio
authors.initials: N
authors.lastname: Tanahashi
mesh_terms: D000230:Adenocarcinoma / Q000150:complications* / Q000175:diagnosis*; D000368:Aged; D003110:Colonic Neoplasms / Q000150:complications* / Q000175:diagnosis*; D003389:Cranial Nerve Diseases / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000209:etiology*; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000134:cerebrospinal fluid / Q000209:etiology; D003639:Hearing Loss, Sudden / Q000134:cerebrospinal fluid / Q000209:etiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D055756:Meningeal Carcinomatosis / Q000134:cerebrospinal fluid / Q000150:complications* / Q000175:diagnosis* / Q000556:secondary; D009382:Neoplasms, Unknown Primary / Q000150:complications / Q000175:diagnosis