title: Spectral and in vitro antimicrobial properties of 2-oxo-4-phenyl-6-styryl-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid transition metal complexes.
abstract: 2-oxo-4-phenyl-6-styryl-1,2,3,4-tetrahydro-pyrimidine-5-carboxylic acid (ADP) was complexed with acetates of Mn(II), Ni(II), Cu(II) and Zn(II). The structures of the ligand and its metal complexes were characterized by microanalysis, IR, NMR, UV-vis spectroscopy, magnetic susceptibility and TGA-DTA analyses. Octahedral and square planar geometries were suggested for the complexes in which the central metal ion coordinated with O donors of ligand and acetate ions. Each ligand binds the metal using carboxylate oxygens. The ligand and complexes were evaluated for their antimicrobial activities against different species of pathogenic bacteria and fungi. The present novel pyrimidine containing complexes could constitute a new group of antibacterial and antifungal agents.
authors.affiliation: Department of Chemistry, Sardar Patel Mahavidyalaya, Ganjward, Chandrapur 442402, Maharashtra, India.
authors.forename: Raksha P
authors.initials: RP
authors.lastname: Dhankar
authors.forename: Anjali M
authors.initials: AM
authors.lastname: Rahatgaonkar
authors.forename: Mukund S
authors.initials: MS
authors.lastname: Chorghade
authors.forename: Ashutosh
authors.initials: A
authors.lastname: Tiwari
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000188:drug therapy; D002264:Carboxylic Acids / Q000737:chemistry / Q000494:pharmacology; D056831:Coordination Complexes / Q000737:chemistry* / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D009181:Mycoses / Q000188:drug therapy; D011743:Pyrimidines / Q000737:chemistry* / Q000494:pharmacology*; D013053:Spectrophotometry; D013055:Spectrophotometry, Infrared; D013818:Thermogravimetry
chemical_list: D000890:Anti-Infective Agents; D002264:Carboxylic Acids; D056831:Coordination Complexes; D011743:Pyrimidines