title: Intrapleural injection of OK-432 as the primary in-utero treatment for fetal chylothorax.
abstract: Chylothorax is a rare congenital condition associated with significant perinatal mortality and morbidity. Previous treatments with repeated thoracocentesis or thoracoamniotic shunting were technically demanding, and associated with significant procedure-related complications and neonatal complications. Here we report the first successful case in Hong Kong treated by a simple and effective intervention, namely pleurodesis with OK-432, in a fetus presenting at 20 weeks of gestation with bilateral pleural effusion.
authors.affiliation: Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong. kittongl@cuhk.edu.hk
authors.forename: Viola K T
authors.initials: VK
authors.lastname: Leung
authors.forename: Stephen S H
authors.initials: SS
authors.lastname: Suen
authors.forename: Y H
authors.initials: YH
authors.lastname: Ting
authors.forename: L W
authors.initials: LW
authors.lastname: Law
authors.forename: T K
authors.initials: TK
authors.lastname: Lau
authors.forename: T Y
authors.initials: TY
authors.lastname: Leung
mesh_terms: D002916:Chylothorax / Q000188:drug therapy*; D005260:Female; D005315:Fetal Diseases / Q000188:drug therapy*; D006801:Humans; D010844:Picibanil / Q000008:administration & dosage*; D018700:Pleurodesis; D011247:Pregnancy
chemical_list: D010844:Picibanil