title: Lack of association between factor V Leiden and prothrombin G20210A polymorphisms in Tunisian subjects with a history of myocardial infarction.
abstract: BACKGROUND
  Myocardial infarction is a multifactorial disease. It is provoked by occlusions in the coronary arteries resulting from exposure to multiple risk factors.
  
  
  OBJECTIVE
  To study the risk of myocardial infarction associated with the gene polymorphisms of factor V Leiden and factor II (G20210A).
  
  
  METHODS
  Cases consisted of 100 myocardial infarction patients who were hospitalized in the Principal Military Hospital of Tunis and 200 control subjects with no history of myocardial infarction.
  
  
  RESULTS
  The prevalence of the factor V Leiden was higher in myocardial infarction patients (9%) than in control subjects (6%) with an OR=1.55 (95% CI=0.58-4.12), whereas the prevalence of prothrombin G20210A mutation was 3% and 2.5% in the patient and control groups, respectively [OR=1.21 (95% CI=0.22-5.94)].
  
  
  CONCLUSIONS
  Our results indicate that neither factor V Leiden nor the prothrombin G20210A contributed to the risk factors for myocardial infarction.
authors.affiliation: Laboratory of Molecular Biology, Department of Hematology, Military Hospital of Tunis, Tunis, Tunisia. dhouha.berredjeb.benslama@gmail.com
authors.forename: Dhouha
authors.initials: D
authors.lastname: Berredjeb Ben Slama
authors.forename: Najiba
authors.initials: N
authors.lastname: Fekih-Mrissa
authors.forename: Abdeddayem
authors.initials: A
authors.lastname: Haggui
authors.forename: Brahim
authors.initials: B
authors.lastname: Nsiri
authors.forename: Nadia
authors.initials: N
authors.lastname: Baraket
authors.forename: Habib
authors.initials: H
authors.lastname: Haouala
authors.forename: Nasreddine
authors.initials: N
authors.lastname: Gritli
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D004252:DNA Mutational Analysis; D005165:Factor V / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006772:Hospitals, Military; D006801:Humans; D008875:Middle Aged; D009154:Mutation; D009203:Myocardial Infarction / Q000235:genetics*; D016017:Odds Ratio; D010641:Phenotype; D011110:Polymorphism, Genetic; D011516:Prothrombin / Q000235:genetics*; D012307:Risk Factors; D014416:Tunisia; D055815:Young Adult
chemical_list: C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin