title: No evidence for infection of UK prostate cancer patients with XMRV, BK virus, Trichomonas vaginalis or human papilloma viruses.
abstract: The prevalence of specific infections in UK prostate cancer patients was investigated. Serum from 84 patients and 62 controls was tested for neutralisation of xenotropic murine leukaemia virus-related virus (XMRV) Envelope. No reactivity was found in the patient samples. In addition, a further 100 prostate DNA samples were tested for XMRV, BK virus, Trichomonas vaginalis and human papilloma viruses by nucleic acid detection techniques. Despite demonstrating DNA integrity and assay sensitivity, we failed to detect the presence of any of these agents in DNA samples, bar one sample that was weakly positive for HPV16. Therefore we conclude that these infections are absent in this typical cohort of men with prostate cancer.
authors.affiliation: Division of Virology, MRC National Institute for Medical Research, London, United Kingdom.
authors.forename: Harriet C T
authors.initials: HC
authors.lastname: Groom
authors.forename: Anne Y
authors.initials: AY
authors.lastname: Warren
authors.forename: David E
authors.initials: DE
authors.lastname: Neal
authors.forename: Kate N
authors.initials: KN
authors.lastname: Bishop
mesh_terms: D057134:Antibodies, Neutralizing / Q000276:immunology; D001739:BK Virus / Q000235:genetics; D015331:Cohort Studies; D004247:DNA / Q000032:analysis; D004266:DNA Virus Infections / Q000150:complications; D006801:Humans; D008297:Male; D027383:Papillomaviridae / Q000235:genetics; D016133:Polymerase Chain Reaction; D027601:Polyomavirus Infections / Q000150:complications; D011471:Prostatic Neoplasms / Q000097:blood / Q000150:complications / Q000821:virology*; D014245:Trichomonas Infections / Q000150:complications; D014246:Trichomonas vaginalis / Q000235:genetics; D014412:Tumor Virus Infections / Q000150:complications; D006113:United Kingdom; D058008:Xenotropic murine leukemia virus-related virus / Q000235:genetics
chemical_list: D057134:Antibodies, Neutralizing; D004247:DNA