title: [Lipid, lipoproteins and atherogenesis profiles in sickle cell disease among Central African patients].
abstract: Lipid and lipopproteins disorders are well established in sera from sickle cell disease (SCD) patients out of Central Africa. The present case-control study was conducted to compare serum levels of total cholesterol (TC), HDL-C, triglycerides (TG), LDL-C and TC/HDL-C ratio (atherogenic index) from SCD homozygotes (SS) in steady state, SCD heterozygotes (AS) and controls (AA) in Brazzaville, Congo. Significant reductions of TC and LDL-C vs. increase in TG were reported in SS. However, significant decrease in HDL-C and increase in atherogenic index were observed in AS. We recommend prevention of oxidative stress, dyslipidemia and atherosclerosis in SCD using hygiene-diet measures. Only longitudinal studies in large populations will provide pathophysiological basis of lipid and lipoproteins disorders in SCD.
authors.affiliation: Laboratoire de biochimie-pharmacologie, Faculté des sciences de la santé, Brazzaville, Congo. mmobet@yahoo.fr
authors.forename: Etienne
authors.initials: E
authors.lastname: Mokondjimobe
authors.forename: Benjamin
authors.initials: B
authors.lastname: Longo-Mbenza
authors.forename: Felix
authors.initials: F
authors.lastname: Ovono-Abessolo
authors.forename: Thierry
authors.initials: T
authors.lastname: Gombet
authors.forename: Guenole
authors.initials: G
authors.lastname: Guie
authors.forename: Edouard
authors.initials: E
authors.lastname: Ngou-Milama
authors.forename: Henri Joseph
authors.initials: HJ
authors.lastname: Parra
mesh_terms: D000293:Adolescent; D000328:Adult; D000350:Africa, Central / Q000453:epidemiology; D000755:Anemia, Sickle Cell / Q000097:blood* / Q000150:complications* / Q000453:epidemiology; D050197:Atherosclerosis / Q000097:blood / Q000209:etiology*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D055442:Metabolome / Q000502:physiology; D008875:Middle Aged; D012307:Risk Factors; D055815:Young Adult
chemical_list: D008055:Lipids; D008074:Lipoproteins