title: Antioxidant supplementation and serum lipids in patients with Graves' disease: effect on LDL-cholesterol.
abstract: The effect of supplementation with a fixed combination of antioxidants (beta-carotene, selenium, vitamins C and E) on serum lipids was monitored in patients with newly detected Graves' disease. Measurements were made prior to the commencement of therapy and after 30 and 60 days. Patients were randomized into two groups. Test group comprised patients who received antioxidant supplementation in addition to methimazole, while patients treated with methimazole only were in the control group. The concentration of total and HDL-cholesterol increased significantly in test and control groups (p < 0.05) but these groups did not differ significantly. Concentration of LDL-cholesterol increased significantly in the test group only (p < 0.005) and was significantly different from the control group 60 days after the commencement of therapy (p < 0.005). Significant increase in the LDL-cholesterol concentration in the test group requires further investigations.
authors.affiliation: Department of Clinical Pharmacy, Faculty of Pharmacy and Biochemistry, University of Zagreb, Croatia. vesnav@kbd.hr
authors.forename: Vesna Bačić
authors.initials: VB
authors.lastname: Vrca
authors.forename: Ljiljana
authors.initials: L
authors.lastname: Mayer
authors.forename: Franjo
authors.initials: F
authors.lastname: Skreb
authors.forename: Dario
authors.initials: D
authors.lastname: Rahelić
authors.forename: Srećko
authors.initials: S
authors.lastname: Marušić
mesh_terms: D000293:Adolescent; D000328:Adult; D000975:Antioxidants / Q000627:therapeutic use*; D013956:Antithyroid Agents / Q000627:therapeutic use; D001205:Ascorbic Acid / Q000627:therapeutic use; D008078:Cholesterol, LDL / Q000097:blood*; D017523:Croatia; D019587:Dietary Supplements; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D005260:Female; D006111:Graves Disease / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008713:Methimazole / Q000627:therapeutic use; D008875:Middle Aged; D012643:Selenium / Q000627:therapeutic use; D013963:Thyroid Hormones / Q000097:blood; D013997:Time Factors; D016896:Treatment Outcome; D014810:Vitamin E / Q000627:therapeutic use; D055815:Young Adult; D019207:beta Carotene / Q000627:therapeutic use
chemical_list: D000975:Antioxidants; D013956:Antithyroid Agents; D008078:Cholesterol, LDL; D004338:Drug Combinations; D013963:Thyroid Hormones; D019207:beta Carotene; D014810:Vitamin E; D008713:Methimazole; D012643:Selenium; D001205:Ascorbic Acid