title: [Association study of brain-derived neurotrophic factor Val66Met polymorphism and clinical characteristics of first episode schizophrenia].
abstract: OBJECTIVE
  To assess the association between brain-derived neurotrophic factor (BDNF) gene Val66Met polymorphism and clinical characteristics of first episode schizophrenia in a Chinese Han population.
  
  
  METHODS
  Genotyping of BDNF Val66Met polymorphism was carried out for 135 schizophrenic patients and 483 healthy controls with TaqMan probe technology. The patients' psychotic symptoms were assessed using the positive and negative syndrome scale (PANSS).
  
  
  RESULTS
  A significant difference was found in genotype distribution and allelic frequency of the Val66Met polymorphism between the two groups (P< 0.01). In patients, Met homozygotes had a significantly higher score in anxiety/depression factor, cognitive factor and total score of PANSS than Val carriers.
  
  
  CONCLUSIONS
  BDNF gene Val66Met polymorphism is associated with the pathogenesis of schizophrenia. The Met/Met genotype of BDNF Val66Met variant may be a risk factor for symptoms in first episode schizophrenia patients.
authors.affiliation: School of Medicine, Shandong University, Jinan, Shandong, People's Republic of China.
authors.forename: Meng-meng
authors.initials: MM
authors.lastname: Sun
authors.forename: Lan-fen
authors.initials: LF
authors.lastname: Liu
authors.forename: Li-min
authors.initials: LM
authors.lastname: Yang
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Kai-yan
authors.initials: KY
authors.lastname: Cui
authors.forename: Li-na
authors.initials: LN
authors.lastname: Wang
authors.forename: Cui-luan
authors.initials: CL
authors.lastname: Li
authors.forename: Dong-dong
authors.initials: DD
authors.lastname: Qiao
authors.forename: Ru-zhan
authors.initials: RZ
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D002681:China; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*; D055815:Young Adult
chemical_list: D019208:Brain-Derived Neurotrophic Factor