title: Effect of weight loss on inflammatory biomarkers in obese dogs.
abstract: The objective of this study was to evaluate the effects of weight loss on selected serum inflammatory biomarkers in obese dogs. An experimentally induced bodyweight reduction of approximately 2.5%/week was accompanied by significant decreases in metabolic markers of obesity (lipidic profile, fructosamine, and insulin-like growth factor-1). The concentrations of acute phase proteins and of selected cytokines remained within reference ranges in obese dogs during weight loss, suggesting that significant inflammation was not a major component of this experimental model. However, adiponectin concentrations increased following the period of weight loss suggesting reduced susceptibility of these animals to obesity-related inflammation.
authors.affiliation: Department of Animal Medicine and Surgery, Faculty of Veterinary Medicine, University of Murcia, 30100 Espinardo, Murcia, Spain.
authors.forename: Asta
authors.initials: A
authors.lastname: Tvarijonaviciute
authors.forename: Fernando
authors.initials: F
authors.lastname: Tecles
authors.forename: Silvia
authors.initials: S
authors.lastname: Martínez-Subiela
authors.forename: José J
authors.initials: JJ
authors.lastname: Cerón
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D001774:Blood Chemical Analysis / Q000662:veterinary; D004283:Dog Diseases / Q000178:diet therapy*; D004285:Dogs; D005260:Female; D007249:Inflammation / Q000097:blood / Q000662:veterinary*; D009765:Obesity / Q000178:diet therapy / Q000662:veterinary*; D015431:Weight Loss
chemical_list: D015415:Biomarkers