title: Insight into the rescue of oxidized soluble guanylate cyclase by the activator cinaciguat.
abstract: Nitric oxide (NO) signaling mediates many important physiological processes through the receptor soluble guanylate cyclase (sGC). Under disease conditions sGC heme can be oxidized resulting in NO insensitivity. Here, we show that the therapeutic compound cinaciguat (Cin) rescues dysfunctional sGC by direct displacement of the oxidized heme.
authors.affiliation: QB3 Institute, University of California, Berkeley, CA 94720, USA.
authors.forename: Nur Basak
authors.initials: NB
authors.lastname: Surmeli
authors.forename: Michael A
authors.initials: MA
authors.lastname: Marletta
mesh_terms: D000818:Animals; D001565:Benzoates / Q000737:chemistry*; D020536:Enzyme Activators / Q000737:chemistry*; D006162:Guanylate Cyclase / Q000737:chemistry* / Q000378:metabolism; D006418:Heme / Q000737:chemistry / Q000378:metabolism; D007700:Kinetics; D009569:Nitric Oxide / Q000737:chemistry; D010084:Oxidation-Reduction; D051381:Rats; D018160:Receptors, Cytoplasmic and Nuclear / Q000737:chemistry* / Q000378:metabolism; D015398:Signal Transduction; D000071756:Soluble Guanylyl Cyclase
chemical_list: D001565:Benzoates; D020536:Enzyme Activators; D018160:Receptors, Cytoplasmic and Nuclear; D009569:Nitric Oxide; C480588:BAY 58-2667; D006418:Heme; D006162:Guanylate Cyclase; D000071756:Soluble Guanylyl Cyclase