title: Does BDNF genotype influence creative output in bipolar I manic patients?
abstract: BACKGROUND
  Creativity is a complex human ability influenced by affective and cognitive components but little is known about its underlying neurobiology. Bipolar Disorder (BD) is highly prevalent among creative individuals. Brain-derived neurotrophic factor (BDNF) is the most widely distributed neurotrophic factor, and has been implicated in the pathophysiology of BD. In contrast to the better functioning of the BDNF polymorphism (Val(66)Met) Val allele, the Met allele decreases BDNF transport and has been associated with worsened performance on several cognitive domains in euthymic BD subjects and controls. We hypothesized that the Val allele is associated with increased creativity in bipolar disorder.
  
  
  METHODS
  Sixty-six subjects with BD (41 in manic and 25 in depressive episodes) and 78 healthy volunteers were genotyped for BDNF Val(66)Met and tested for creativity using the Barrow Welsh Art Scale (BWAS) and neuropsychological tests.
  
  
  RESULTS
  Manic patients with the Val allele (Met-) had higher BWAS scores than Met+ carriers. This relationship was not observed among patients in depressive episodes or among control subjects. BDNF Met allele status showed no association with cognitive function in any of the groups.
  
  
  CONCLUSIONS
  As postulated, these findings suggest that the better functioning allele of BDNF may selectively facilitate creative thinking in subjects with manic episodes, but not in controls or depressives. Further studies exploring the role of BDNF in the neurobiology of creativity in BD and in euthymic phases are warranted.
authors.affiliation: Mood Disorders Unit GRUDA, Department and Institute of Psychiatry, School of Medicine, University of Sao Paulo (IPq HC-FMUSP), Brazil. mgss@usp.br
authors.forename: Márcio Gerhardt
authors.initials: MG
authors.lastname: Soeiro-de-Souza
authors.forename: Robert M
authors.initials: RM
authors.lastname: Post
authors.forename: Mario Lucio
authors.initials: ML
authors.lastname: de Sousa
authors.forename: Giovani
authors.initials: G
authors.lastname: Missio
authors.forename: Carolina Martins
authors.initials: CM
authors.lastname: do Prado
authors.forename: Wagner F
authors.initials: WF
authors.lastname: Gattaz
authors.forename: Ricardo A
authors.initials: RA
authors.lastname: Moreno
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Machado-Vieira
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D001714:Bipolar Disorder / Q000235:genetics* / Q000503:physiopathology / Q000523:psychology; D019208:Brain-Derived Neurotrophic Factor / Q000235:genetics*; D003405:Creativity; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D055815:Young Adult
chemical_list: D019208:Brain-Derived Neurotrophic Factor