title: Synthesis and antitumor-evaluation of 1,3,4-thiadiazole-containing benzisoselenazolone derivatives.
abstract: A series of novel 1,3,4-thiadiazole-containing benzisoselenazolone derivatives were prepared by the condensation of 2-chloroselenobenzoyl chloride and 2-amino-5-substituted-1,3,4-thiadiazole. Their in vitro antiproliferative activities were evaluated in SSMC-7721, MCF-7 and A-549 cells. The results suggest that, in different tumor cells, some compounds have good antiproliferative activity, certain selectivity and potential value of further research.
authors.affiliation: Department of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, China.
authors.forename: Zhenhua
authors.initials: Z
authors.lastname: Luo
authors.forename: Baoquan
authors.initials: B
authors.lastname: Chen
authors.forename: Shuangyan
authors.initials: S
authors.lastname: He
authors.forename: Yanping
authors.initials: Y
authors.lastname: Shi
authors.forename: Yuming
authors.initials: Y
authors.lastname: Liu
authors.forename: Caiwen
authors.initials: C
authors.lastname: Li
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001393:Azoles / Q000138:chemical synthesis* / Q000494:pharmacology; D045744:Cell Line, Tumor; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D001393:Azoles; D013830:Thiadiazoles; C058949:1,3,4-thiadiazole