title: Novel positron emission tomography/computed tomography of diffuse parenchymal lung disease combining a labeled somatostatin receptor analogue and 2-deoxy-2[18F]fluoro-D-glucose.
abstract: We prospectively investigated the potential of positron emission tomography (PET) using the somatostatin receptor (SSTR) analogue ⁶⁸Ga-DOTATATE and 2-deoxy-2[¹⁸F]fluoro-D-glucose (¹⁸F-FDG) in diffuse parenchymal lung disease (DPLD). Twenty-six patients (mean age 68.9 ± 11.0 years) with DPLD were recruited for ⁶⁸Ga-DOTATATE and ¹⁸F-FDG combined PET/high-resolution computed tomography (HRCT) studies. Ten patients had idiopathic pulmonary fibrosis (IPF), 12 patients had nonspecific interstitial pneumonia (NSIP), and 4 patients had other forms of DPLD. Using PET, the pulmonary tracer uptake (maximum standardized uptake value [SUV(max)]) was calculated. The distribution of PET tracer was compared to the distribution of lung parenchymal changes on HRCT. All patients demonstrated increased pulmonary PET signal with ⁶⁸Ga-DOTATATE and ¹⁸F-FDG. The distribution of parenchymal uptake was similar, with both tracers corresponding to the distribution of HRCT changes. The mean SUV(max) was 2.2 ± 0.7 for ⁶⁸Ga-DOTATATE and 2.8 ± 1.0 (t-test, p  =  .018) for ¹⁸F-FDG. The mean ⁶⁸Ga-DOTATATE SUV(max) in IPF patients was 2.5 ± 0.9, whereas it was 2.0 ± 0.7 (p  =  .235) in NSIP patients. The correlation between ⁶⁸Ga-DOTATATE SUV(max) and gas transfer (transfer factor of the lung for carbon monoxide [TLCO]) was r  =  -.34 (p  =  .127) and r  =  -.49 (p  =  .028) between ¹⁸F-FDG SUV(max) and TLCO. We provide noninvasive in vivo evidence in humans showing that SSTRs may be detected in the lungs of patients with DPLD in a similar distribution to sites of increased uptake of ¹⁸F-FDG on PET.
authors.affiliation: Department of Respiratory Medicine, Lister Hospital, Stevenage, UK.
authors.forename: Thida
authors.initials: T
authors.lastname: Win
authors.forename: Nicholas J
authors.initials: NJ
authors.lastname: Screaton
authors.forename: Joanna
authors.initials: J
authors.lastname: Porter
authors.forename: Raymondo
authors.initials: R
authors.lastname: Endozo
authors.forename: Damian
authors.initials: D
authors.lastname: Wild
authors.forename: Irfan
authors.initials: I
authors.lastname: Kayani
authors.forename: John
authors.initials: J
authors.lastname: Dickson
authors.forename: Robert I
authors.initials: RI
authors.lastname: Shortman
authors.forename: Jean C
authors.initials: JC
authors.lastname: Reubi
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Ell
authors.forename: Ashley M
authors.initials: AM
authors.lastname: Groves
mesh_terms: D000368:Aged; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D054988:Idiopathic Interstitial Pneumonias / Q000000981:diagnostic imaging; D054990:Idiopathic Pulmonary Fibrosis / Q000000981:diagnostic imaging; D017563:Lung Diseases, Interstitial / Q000000981:diagnostic imaging*; D008297:Male; D064847:Multimodal Imaging / Q000379:methods*; D049268:Positron-Emission Tomography; D017481:Receptors, Somatostatin / Q000378:metabolism*; D013194:Staining and Labeling; D014057:Tomography, X-Ray Computed
chemical_list: D017481:Receptors, Somatostatin; D019788:Fluorodeoxyglucose F18