title: Biopsy from the base and edge of gastric ulcer healing or complete healing may lead to detection of gastric cancer earlier: an 8 years endoscopic follow-up study.
abstract: OBJECTIVE
  To assess the incidence of gastric cancer development in gastric benign ulcer patients and to evaluate the value of biopsy by taking specimens from both the base and edges of ulcers in contrast to the traditional biopsy which takes specimens from the edges of ulcers only.
  
  
  METHODS
  An endoscopic followup of more than 1 year was conducted on 456 gastric ulcer patients in our hospital for a duration over 8 years. We collected clinical, endoscopic and pathological data and obtained at least 6 biopsies from both the edges and the bases of ulcers healing or complete healing, respectively and assessed H. pylori infection.
  
  
  RESULTS
  Gastric cancers developed in 11 (2.41%) of 456 GU patients. In the experimental group, 3 cases that were diagnosed by histology showed adenocarcinoma with specimens taken from the ulcer bases and in the other 5 cases the specimens were taken from the ulcer edges. The detection rate of gastric cancer from gastric ulcer between experimental group and control group was statistically significant (4.57% vs. 1.07%, p<0.05).
  
  
  CONCLUSIONS
  Gastric ulcer may develop into gastric cancer over a certain period of time in patients infected with H. pylori. Biopsies from ulcer bases and edges at the second or subsequent endoscopies may lead to defection of gastric cancer earlier and more effectively than the biopsies which take specimens from the edges of ulcers only.
authors.affiliation: Department of Hepatology and Gastroenterology, Soochow University, Soochow, People's Republic of China.
authors.forename: Sheng-Xiang
authors.initials: SX
authors.lastname: Lv
authors.forename: Jian-He
authors.initials: JH
authors.lastname: Gan
authors.forename: Xing-Gang
authors.initials: XG
authors.lastname: Ma
authors.forename: Chang-Cheng
authors.initials: CC
authors.lastname: Wang
authors.forename: Hong-Mei
authors.initials: HM
authors.lastname: Chen
authors.forename: Er-Ping
authors.initials: EP
authors.lastname: Luo
authors.forename: Xiao-Ping
authors.initials: XP
authors.lastname: Huang
authors.forename: Shao-Hong
authors.initials: SH
authors.lastname: Wu
authors.forename: Ai-Lan
authors.initials: AL
authors.lastname: Qin
authors.lastname: Ke-Chen
authors.forename: Xiao-Hong
authors.initials: XH
authors.lastname: Wang
authors.lastname: Wei-Sun
authors.lastname: Li-Chen
authors.lastname: Ying-Xie
authors.forename: Feng-Xia
authors.initials: FX
authors.lastname: Hu
authors.lastname: Dan-Niu
authors.forename: Sarika
authors.initials: S
authors.lastname: Walia
authors.forename: Jian
authors.initials: J
authors.lastname: Zhu
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology / Q000382:microbiology / Q000473:pathology*; D000368:Aged; D001706:Biopsy; D002681:China / Q000453:epidemiology; D055088:Early Detection of Cancer; D005500:Follow-Up Studies; D005773:Gastroscopy; D016481:Helicobacter Infections / Q000453:epidemiology / Q000382:microbiology / Q000473:pathology; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions / Q000453:epidemiology / Q000382:microbiology / Q000473:pathology*; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000382:microbiology / Q000473:pathology*; D013276:Stomach Ulcer / Q000453:epidemiology / Q000382:microbiology / Q000473:pathology*; D013997:Time Factors; D014945:Wound Healing