title: Inhibition of quorum sensing regulated biofilm formation in Serratia marcescens causing nosocomial infections.
abstract: Serratia marcescens is an opportunistic pathogen causing severe urinary tract infections in hospitalized individuals. Infections of S. marcescens are of great concern because of its increasing resistance towards conventional antibiotics. Quorum sensing (QS)-a cell to cell communication-system of S. marcescens acts as a global regulator of almost all the virulence factors and majorly its biofilm formation. Since, the QS system of S. marcescens directly accords to its pathogenesis, targeting QS system will provide an improved strategy to combat drug resistant pathogens. In the present study, QS system of S. marcescens has been used as target and its inhibition has been studied upon exposure to bioactives from coral associated bacteria (CAB). This study also emphasises the potential of CAB in producing bioactive agents with anti-QS and antibiofilm properties. Two CAB isolates CAB 23 and 41 have shown to inhibit biofilm formation and the production of QS dependent virulence factors like prodigiosin, protease, lipase and swarming motility. The study, on the whole explicates the potential of QS system as a target to treat drug resistant bacterial infections.
authors.affiliation: Department of Biotechnology, Alagappa University, Karaikudi 630 003, India.
authors.forename: Dhamodharan
authors.initials: D
authors.lastname: Bakkiyaraj
authors.forename: Chandran
authors.initials: C
authors.lastname: Sivasankar
authors.forename: Shunmugiah Karutha
authors.initials: SK
authors.lastname: Pandian
mesh_terms: D000818:Animals; D037421:Anthozoa / Q000382:microbiology; D000900:Anti-Bacterial Agents; D018441:Biofilms / Q000187:drug effects; D003428:Cross Infection / Q000188:drug therapy; D053038:Quorum Sensing / Q000187:drug effects*; D016868:Serratia Infections / Q000188:drug therapy; D012706:Serratia marcescens / Q000187:drug effects* / Q000472:pathogenicity; D037521:Virulence Factors
chemical_list: D000900:Anti-Bacterial Agents; D037521:Virulence Factors