title: Diabetes before and after lung transplantation in patients with cystic fibrosis and other lung diseases.
abstract: OBJECTIVE
  The aims of the study are to investigate the prevalence of diabetes in patients with cystic fibrosis compared with patients without cystic fibrosis, and its impact on the outcome after lung transplantation.
  
  
  METHODS
  Data were reviewed from 77 lung transplantation recipients in our centre between 2001 and 2010; 43 patients had cystic fibrosis and 34 patients had other lung diseases (no cystic fibrosis). To define diabetes, we used the American Diabetes Association definition.
  
  
  RESULTS
  Before lung transplantation, diabetes was diagnosed in 63% of patients with cystic fibrosis and 6% of patients without cystic fibrosis (P<0.001). In both groups, approximately 60% of the patients at risk developed new-onset diabetes after transplantation. The mortality in patients with cystic fibrosis was higher in patients with diabetes diagnosed before lung transplantation compared with those without (44 vs. 6%, P=0.04). Diabetes remained an independent factor in multivariate analyses.
  
  
  CONCLUSIONS
  Diabetes diagnosed before lung transplantation has a negative effect on survival after lung transplantation in patients with cystic fibrosis. Pre-existing diabetes is common in patients with cystic fibrosis, in contrast to patients without cystic fibrosis. Development of new-onset diabetes after transplantation is similar in both groups.
authors.affiliation: Department of Internal Medicine, University Medical Centre Utrecht, Utrecht, The Netherlands. g.vanmeerkerk@umcutrecht.nl
authors.forename: G
authors.initials: G
authors.lastname: Belle-van Meerkerk
authors.forename: E A
authors.initials: EA
authors.lastname: van de Graaf
authors.forename: J M
authors.initials: JM
authors.lastname: Kwakkel-van Erp
authors.forename: D A
authors.initials: DA
authors.lastname: van Kessel
authors.forename: J-W J
authors.initials: JW
authors.lastname: Lammers
authors.forename: D H
authors.initials: DH
authors.lastname: Biesma
authors.forename: H W
authors.initials: HW
authors.lastname: de Valk
mesh_terms: D000328:Adult; D015331:Cohort Studies; D003550:Cystic Fibrosis / Q000150:complications* / Q000401:mortality / Q000601:surgery; D048909:Diabetes Complications / Q000453:epidemiology / Q000401:mortality; D003920:Diabetes Mellitus / Q000175:diagnosis* / Q000401:mortality; D005260:Female; D006801:Humans; D015994:Incidence; D008171:Lung Diseases / Q000150:complications / Q000401:mortality / Q000601:surgery; D016040:Lung Transplantation / Q000706:statistics & numerical data*; D008297:Male; D011183:Postoperative Complications / Q000401:mortality; D057234:Preoperative Period; D015995:Prevalence; D012307:Risk Factors; D016896:Treatment Outcome; D014481:United States / Q000453:epidemiology; D055815:Young Adult