title: Effect of surface-functionalized nanoparticles on the elongation phase of beta-amyloid (1-40) fibrillogenesis.
abstract: The influence of nanoparticles of various sizes and surface functionalities on the self-assembling fibrillogenesis of beta-amyloid (1-40) peptide was investigated. Functionalized nanoparticles including quantum dots and gold nanoparticles were co-incubated with monomeric Aβ(1-40) peptides under seed-mediated growth method to study their influences on the elongation phase of the fibrillogenesis. It is observed that charge-to-surface area ratio of the nanoparticles and the functional moiety and electrostatic charges of the conjugated ligands on the particle surfaces took crucial regulatory role in the Aβ(1-40) fibrillogenesis.
authors.affiliation: Department of Chemistry, Hong Kong Baptist University, Kowloon Tong, Hong Kong, PR China.
authors.forename: Ho-Man
authors.initials: HM
authors.lastname: Chan
authors.forename: Lehui
authors.initials: L
authors.lastname: Xiao
authors.forename: Kai-Ming
authors.initials: KM
authors.lastname: Yeung
authors.forename: See-Lok
authors.initials: SL
authors.lastname: Ho
authors.forename: Dan
authors.initials: D
authors.lastname: Zhao
authors.forename: Wing-Hong
authors.initials: WH
authors.lastname: Chan
authors.forename: Hung-Wing
authors.initials: HW
authors.lastname: Li
mesh_terms: D016229:Amyloid beta-Peptides / Q000737:chemistry* / Q000648:ultrastructure; D053768:Metal Nanoparticles / Q000737:chemistry* / Q000648:ultrastructure; D046529:Microscopy, Electron, Transmission; D010446:Peptide Fragments / Q000737:chemistry* / Q000648:ultrastructure; D045663:Quantum Dots
chemical_list: D016229:Amyloid beta-Peptides; D010446:Peptide Fragments; C078592:amyloid beta-protein (1-40)