title: Bortezomib-associated fatal liver failure in a haemodialysis patient with multiple myeloma.
abstract: BACKGROUND
  Bortezomib is a proteasome inhibitor with excellent antimyeloma activity. The most frequent toxic side effects are gastrointestinal, neuropathy and thrombocytopenia. The liver was not considered an important target organ for toxicity until one case of bortezomib-induced severe hepatitis was reported in a patient with multiple myeloma.
  
  
  METHODS
  We describe a patient developing acute cholestatic and parenchymal hepatitis complicated by fatal liver failure after bortezomib therapy for multiple myeloma.
  
  
  CONCLUSIONS
  The importance of being aware of this potential fatal complication is emphasized considering that this drug is increasingly prescribed and in order to discontinue this drug if liver adverse reaction is suspected.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Maastricht University Medical Center, Maastricht, The Netherlands. tom.cornelis@mumc.nl
authors.forename: Tom
authors.initials: T
authors.lastname: Cornelis
authors.forename: Erik A M
authors.initials: EA
authors.lastname: Beckers
authors.forename: Ann L C
authors.initials: AL
authors.lastname: Driessen
authors.forename: Frank M
authors.initials: FM
authors.lastname: van der Sande
authors.forename: Ger H
authors.initials: GH
authors.lastname: Koek
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001897:Boronic Acids / Q000009:adverse effects* / Q000627:therapeutic use; D000069286:Bortezomib; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D002779:Cholestasis / Q000139:chemically induced; D017809:Fatal Outcome; D006801:Humans; D017093:Liver Failure / Q000139:chemically induced*; D008297:Male; D009101:Multiple Myeloma / Q000188:drug therapy; D011719:Pyrazines / Q000009:adverse effects* / Q000627:therapeutic use; D006435:Renal Dialysis
chemical_list: D000970:Antineoplastic Agents; D001897:Boronic Acids; D011719:Pyrazines; D000069286:Bortezomib