title: A bioabsorbable microclip for laryngeal microsurgery: design and evaluation.
abstract: Epithelial flaps created during laryngeal microsurgery require apposition to facilitate proper healing. Current technologies are restricted by minimal access of the surgical site, posing various limitations in application. In this paper, we propose a novel magnesium-based bioabsorbable microclip, discuss our design considerations and evaluate the microclip's feasibility as a miniature wound closure device. Ex vivo experiments demonstrate that the microclip fastens securely to the vocal fold, while in vivo studies show bioabsorbability and a lack of adverse side effects, suggesting that the microclips are viable as implantable devices.
authors.affiliation: Department of Mechanical Engineering, National University of Singapore, Singapore.
authors.forename: C B
authors.initials: CB
authors.lastname: Chng
authors.forename: D P
authors.initials: DP
authors.lastname: Lau
authors.forename: J Q
authors.initials: JQ
authors.lastname: Choo
authors.forename: C K
authors.initials: CK
authors.lastname: Chui
mesh_terms: D020341:Absorbable Implants; D000818:Animals; D004867:Equipment Design; D006863:Hydrogen-Ion Concentration / Q000187:drug effects; D066298:In Vitro Techniques; D007830:Larynx / Q000187:drug effects / Q000601:surgery*; D008274:Magnesium / Q000494:pharmacology; D008855:Microscopy, Electron, Scanning; D008866:Microsurgery / Q000295:instrumentation*; D055616:Microtechnology; D011091:Polyesters / Q000494:pharmacology; D013499:Surface Properties / Q000187:drug effects; D013524:Surgical Flaps; D034421:Sus scrofa
chemical_list: D011091:Polyesters; C016240:polycaprolactone; D008274:Magnesium