title: Nanostructured oxygen sensor--using micelles to incorporate a hydrophobic platinum porphyrin.
abstract: Hydrophobic platinum(II)-5,10,15,20-tetrakis-(2,3,4,5,6-pentafluorophenyl)-porphyrin (PtTFPP) was physically incorporated into micelles formed from poly(ε-caprolactone)-block-poly(ethylene glycol) to enable the application of PtTFPP in aqueous solution. Micelles were characterized using dynamic light scattering (DLS) and atomic force microscopy (AFM) to show an average diameter of about 140 nm. PtTFPP showed higher quantum efficiency in micellar solution than in tetrahydrofuran (THF) and dichloromethane (CH₂Cl₂). PtTFPP in micelles also exhibited higher photostability than that of PtTFPP suspended in water. PtTFPP in micelles exhibited good oxygen sensitivity and response time. This study provided an efficient approach to enable the application of hydrophobic oxygen sensors in a biological environment.
authors.affiliation: Center for Biosignatures Discovery Automation, Biodesign Institute, Arizona State University, Tempe, Arizona, United States of America.
authors.forename: Fengyu
authors.initials: F
authors.lastname: Su
authors.forename: Ruhaniyah
authors.initials: R
authors.lastname: Alam
authors.forename: Qian
authors.initials: Q
authors.lastname: Mei
authors.forename: Yanqing
authors.initials: Y
authors.lastname: Tian
authors.forename: Cody
authors.initials: C
authors.lastname: Youngbull
authors.forename: Roger H
authors.initials: RH
authors.lastname: Johnson
authors.forename: Deirdre R
authors.initials: DR
authors.lastname: Meldrum
mesh_terms: D008823:Micelles; D018625:Microscopy, Atomic Force; D049329:Nanostructures; D010100:Oxygen / Q000032:analysis*; D055668:Photochemical Processes; D010984:Platinum / Q000737:chemistry*; D011166:Porphyrins / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D008823:Micelles; D011166:Porphyrins; D010984:Platinum; D010100:Oxygen