title: Bilateral ovarian adenocarcinoma in a mare causing haemoperitoneum and colic.
abstract: METHODS
  A 13-year-old Thoroughbred mare was presented with a history of mild colic over 3 days. This colic had acutely exacerbated and was unresponsive to analgesic treatment, and was referred to Massey University Veterinary Teaching Hospital.
  
  
  RESULTS
  On examination the heart rate was 100 beats per minute, and mucous membranes were pale and tacky. A large mass was detected on transrectal palpation in the caudal abdomen to the left of midline. Explorative laparotomy revealed severe haemoperitoneum and several masses that were associated with the reproductive tract. The mare was then subject to euthanasia. On post-mortem examination, adjacent and attached to each ovary were soft, lobulated dark red masses up to 200 mm in diameter. Similar masses were present in the omentum and on the peritoneal surface of the diaphragm and the serosa of the spleen and liver. Histopathology revealed that the neoplastic component of the masses comprised proliferating cuboidal to columnar cells forming disorganised acini and cords separated by dense collagenous stroma. Immunohistochemistry showed the neoplastic cells were positive for cytokeratin AE1/AE3 and vimentin, but negative for cytokeratin 7 and inhibin α.
  
  
  METHODS
  Bilateral ovarian adenocarcinoma with transcoelomic metastasis and terminal decompensation due to rupture of a neoplastic mass and consequent haemoperitoneum.
  
  
  CONCLUSIONS
  To the authors' knowledge, bilateral ovarian adenocarcinoma has not been previously reported in a horse. Ovarian adenocarcinoma should be considered when horses present with haemoperitoneum and colic. Further research is required on the immunohistochemical differentiation of adenocarcinoma of ovarian and intestinal origin in the horse.
authors.affiliation: Institute of Veterinary, Animal and Biomedical Sciences, Massey University, Palmerston North, New Zealand. f.pauwels@massey.ac.nz
authors.forename: F E T
authors.initials: FE
authors.lastname: Pauwels
authors.forename: S J
authors.initials: SJ
authors.lastname: Wigley
authors.forename: J S
authors.initials: JS
authors.lastname: Munday
authors.forename: W D
authors.initials: WD
authors.lastname: Roe
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D003085:Colic / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D005260:Female; D006465:Hemoperitoneum / Q000209:etiology / Q000662:veterinary*; D006734:Horse Diseases / Q000209:etiology / Q000473:pathology*; D006736:Horses; D010051:Ovarian Neoplasms / Q000150:complications / Q000473:pathology / Q000662:veterinary*