title: Sensitivity of whole blood clotting time and activated partial thromboplastin time for factor IX: relevance to gene therapy and determination of post-transfusion elimination time of canine factor IX in hemophilia B dogs.
authors.affiliation: The Department of Pathology and Laboratory Medicine, The University of North Carolina, Chapel Hill, NC, USA. tnichols@med.unc.edu
authors.forename: T C
authors.initials: TC
authors.lastname: Nichols
authors.forename: H W G
authors.initials: HW
authors.lastname: Franck
authors.forename: C T
authors.initials: CT
authors.lastname: Franck
authors.forename: N
authors.initials: N
authors.lastname: De Friess
authors.forename: R A
authors.initials: RA
authors.lastname: Raymer
authors.forename: E P
authors.initials: EP
authors.lastname: Merricks
mesh_terms: D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects / Q000235:genetics; D003029:Coagulants / Q000008:administration & dosage* / Q000493:pharmacokinetics; D004195:Disease Models, Animal; D004285:Dogs; D004797:Enzyme-Linked Immunosorbent Assay; D005164:Factor IX / Q000008:administration & dosage* / Q000235:genetics* / Q000493:pharmacokinetics; D015316:Genetic Therapy; D006467:Hemophilia A / Q000097:blood / Q000235:genetics / Q000628:therapy*; D008657:Metabolic Clearance Rate; D010314:Partial Thromboplastin Time; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D014914:Whole Blood Coagulation Time
chemical_list: D003029:Coagulants; D005164:Factor IX