title: A six-month supplementation of mulberry, korean red ginseng, and banaba decreases biomarkers of systemic low-grade inflammation in subjects with impaired glucose tolerance and type 2 diabetes.
abstract: We sought the long-term efficacy of traditionally used antidiabetic herbs in controlling blood glucose homeostasis and low-grade inflammation. Ninety-four subjects with either impaired glucose tolerance or mild T2D were randomized either to treatment arm or placebo arm and received 1 : 1 : 1 mixture of ginseng roots, mulberry leaf water extract, and banaba leaf water extract (6 g/d) for 24 weeks. Oral 75 g glucose tolerance test was performed to measure glucose and insulin responses. Blood biomarkers of low-grade inflammation were also determined. Results found no significant difference in glucose homeostasis control measure changes. However, plasma intracellular adhesion molecule-1 (ICAM-1) concentration was decreased showing a significant between-treatment changes (P = 0.037). The concentrations of vascular cell adhesion molecule-1 (VCAM-1) (P = 0.014) and ICAM-1 (P = 0.048) were decreased in the treatment group at week 24, and the oxidized low-density lipoprotein (ox-LDL) concentration was reduced at week 24 compared to the baseline value in the treatment group (P = 0.003). These results indicate a long-term supplementation of ginseng, mulberry leaf, and banaba leaf suppresses inflammatory responses in T2D.
authors.affiliation: Department of Food and Nutrition, Sookmyung Women's University, Yongsan-gu, Seoul 140-742, Republic of Korea.
authors.forename: H-J
authors.initials: HJ
authors.lastname: Kim
authors.forename: K-H
authors.initials: KH
authors.lastname: Yoon
authors.forename: M-J
authors.initials: MJ
authors.lastname: Kang
authors.forename: H-W
authors.initials: HW
authors.lastname: Yim
authors.forename: K-S
authors.initials: KS
authors.lastname: Lee
authors.forename: V
authors.initials: V
authors.lastname: Vuksan
authors.forename: M-K
authors.initials: MK
authors.lastname: Sung