title: Skin lesions, malaise, and heart failure in a renal transplant recipient.
abstract: A male Caucasian patient developed nodular erythematous skin lesions, malaise, and clinical signs of progressive heart failure 4 months after renal transplantation. Bronchoscopy with bronchoalveolar lavage performed for a small infiltrate seen on a computed tomography scan revealed Trypanosoma, which had at this point not been suspected as a cause. Parasitemia was present, and reactivation rather than transmission of Chagas' disease was established by performing polymerase chain reaction and serology in the donor and recipient. Treatment with benznidazole and allopurinol successfully reduced parasitemia, but the clinical course was fatal owing to progression of severe myocarditis. The patient had never lived in an endemic area, but had an extensive travel history in South America. The last visit was more than 5 years before transplantation. In non-endemic countries (United States, Europe), reactivation after transplantation has only been very rarely reported. Given the rising numbers of transplantations in patients with a migration background and extensive travel histories, specific screening procedures have to be considered.
authors.affiliation: Division of Infectious Diseases and Hospital Epidemiology, University Hospital of Zurich, Zurich, Switzerland.
authors.forename: C
authors.initials: C
authors.lastname: Kocher
authors.forename: S
authors.initials: S
authors.lastname: Segerer
authors.forename: A
authors.initials: A
authors.lastname: Schleich
authors.forename: R
authors.initials: R
authors.lastname: Caduff
authors.forename: L G
authors.initials: LG
authors.lastname: Wyler
authors.forename: V
authors.initials: V
authors.lastname: Müller
authors.forename: B
authors.initials: B
authors.lastname: Beck
authors.forename: J
authors.initials: J
authors.lastname: Blum
authors.forename: J
authors.initials: J
authors.lastname: Kamarachev
authors.forename: N J
authors.initials: NJ
authors.lastname: Mueller
mesh_terms: D000328:Adult; D000913:Antibodies, Protozoan / Q000097:blood; D002598:Chagas Cardiomyopathy / Q000150:complications* / Q000469:parasitology / Q000503:physiopathology; D014355:Chagas Disease / Q000150:complications* / Q000469:parasitology / Q000503:physiopathology; D017809:Fatal Outcome; D006333:Heart Failure / Q000209:etiology*; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D009205:Myocarditis / Q000150:complications / Q000469:parasitology; D018512:Parasitemia / Q000150:complications / Q000469:parasitology; D012867:Skin / Q000469:parasitology / Q000473:pathology; D012876:Skin Diseases, Parasitic / Q000469:parasitology* / Q000503:physiopathology; D014349:Trypanosoma cruzi / Q000235:genetics* / Q000276:immunology
chemical_list: D000913:Antibodies, Protozoan