title: The young brain and concussion: imaging as a biomarker for diagnosis and prognosis.
abstract: Concussion (mild traumatic brain injury (mTBI)) is a significant pediatric public health concern. Despite increased awareness, a comprehensive understanding of the acute and chronic effects of concussion on central nervous system structure and function remains incomplete. Here we review the definition, epidemiology, and sequelae of concussion within the developing brain, during childhood and adolescence, with current data derived from studies of pathophysiology and neuroimaging. These findings may contribute to a better understanding of the neurological consequences of traumatic brain injuries, which in turn, may lead to the development of brain biomarkers to improve identification, management and prognosis of pediatric patients suffering from concussion.
authors.affiliation: Center for Pain and the Brain, Children's Hospital Boston, Harvard Medical School, United States.
authors.forename: Esteban
authors.initials: E
authors.lastname: Toledo
authors.forename: Alyssa
authors.initials: A
authors.lastname: Lebel
authors.forename: Lino
authors.initials: L
authors.lastname: Becerra
authors.forename: Anna
authors.initials: A
authors.lastname: Minster
authors.forename: Clas
authors.initials: C
authors.lastname: Linnman
authors.forename: Nasim
authors.initials: N
authors.lastname: Maleki
authors.forename: David W
authors.initials: DW
authors.lastname: Dodick
authors.forename: David
authors.initials: D
authors.lastname: Borsook
mesh_terms: D015415:Biomarkers; D001921:Brain / Q000503:physiopathology*; D001924:Brain Concussion / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D059906:Neuroimaging / Q000379:methods*; D011379:Prognosis
chemical_list: D015415:Biomarkers