title: Invasive pulmonary aspergillosis due to a multi-azole resistant Aspergillus fumigatus.
abstract: A patient with invasive pulmonary aspergillosis due to an azole-resistant Aspergillus fumigatus is described. Despite treatment change from voriconazole to amphotericin B as soon as the resistance data were available, the patient died. Azole resistance is an emerging problem, which significantly complicates the management of A. fumigatus infections. It should be considered in every patient with an invasive A. fumigatus infection who is not responding to voriconazole therapy.
authors.affiliation: Department of Microbiology, GZA St. Augustinus, Wilrijk, Belgium.
authors.forename: A
authors.initials: A
authors.lastname: Jeurissen
authors.forename: S
authors.initials: S
authors.lastname: Cooreman
authors.forename: W
authors.initials: W
authors.lastname: Van Kerckhoven
authors.forename: J
authors.initials: J
authors.lastname: Van Leemput
authors.forename: P
authors.initials: P
authors.lastname: Vanhove
authors.forename: K
authors.initials: K
authors.lastname: Lagrou
authors.forename: L
authors.initials: L
authors.lastname: Heytens
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use*; D001232:Aspergillus fumigatus; D001393:Azoles / Q000627:therapeutic use*; D026141:Drug Resistance, Multiple, Fungal; D006801:Humans; D055744:Invasive Pulmonary Aspergillosis / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology*; D008297:Male; D008875:Middle Aged
chemical_list: D000935:Antifungal Agents; D001393:Azoles