title: IFITM proteins restrict antibody-dependent enhancement of dengue virus infection.
abstract: Interferon-inducible transmembrane (IFITM) proteins restrict the entry processes of several pathogenic viruses, including the flaviviruses West Nile virus and dengue virus (DENV). DENV infects cells directly or via antibody-dependent enhancement (ADE) in Fc-receptor-bearing cells, a process thought to contribute to severe disease in a secondary infection. Here we investigated whether ADE-mediated DENV infection bypasses IFITM-mediated restriction or whether IFITM proteins can be protective in a secondary infection. We observed that IFITM proteins restricted ADE-mediated and direct infection with comparable efficiencies in a myelogenous leukemia cell line. Our data suggest that IFITM proteins can contribute to control of secondary DENV infections.
authors.affiliation: New England Primate Research Center, Department of Microbiology and Immunobiology, Harvard Medical School, Southborough, Massachusetts, United States of America. ykchan@fas.harvard.edu
authors.forename: Ying Kai
authors.initials: YK
authors.lastname: Chan
authors.forename: I-Chueh
authors.initials: IC
authors.lastname: Huang
authors.forename: Michael
authors.initials: M
authors.lastname: Farzan
mesh_terms: D000818:Animals; D019067:Antibody-Dependent Enhancement; D002460:Cell Line; D045744:Cell Line, Tumor; D003715:Dengue / Q000276:immunology* / Q000821:virology; D003716:Dengue Virus / Q000276:immunology*; D006801:Humans; D007372:Interferons / Q000276:immunology*; D008565:Membrane Proteins / Q000276:immunology*; D051379:Mice
chemical_list: D008565:Membrane Proteins; D007372:Interferons