title: Second trimester maternal plasma levels of cytokines IL-1Ra, Il-6 and IL-10 and preterm birth.
abstract: OBJECTIVE
  To examine the interaction of the cytokines interleukin-1 receptor antagonist (IL)-1Ra, IL-6 and IL-10 to predict preterm birth (PTB) in pregnant Hispanic women (n=470).
  
  
  METHODS
  In this prospective study, demographic data were obtained prenatally and birth outcome data were obtained from the medical chart. Cytokines were measured from plasma obtained at 22 to 24 weeks gestation. Data analysis utilized logistic regression.
  
  
  RESULTS
  PTB was predicted by level of IL-1Ra (odds ratio (OR)=2.55; 95% confidence interval (CI)=1.24, 5.24). The interaction between IL-1Ra and IL-6 and between IL-1Ra and IL-10 was significant (Wald=4.01, P=0.04 and Wald=8.84, P<0.003, respectively) and was also predictive of PTB. As IL-1Ra levels increased while IL-10 levels were low, the probability of PTB greatly increased.
  
  
  CONCLUSIONS
  The interactions of select cytokines and cytokine receptor antagonists were associated with PTB. Future research should focus on the changes in cytokines during pregnancy to identify critical periods of change, and examine predictors of the cytokine response.
authors.affiliation: School of Nursing, The University of Texas at Austin, Austin, TX, USA. jruiz@austin.utexas.edu
authors.forename: R J
authors.initials: RJ
authors.lastname: Ruiz
authors.forename: N
authors.initials: N
authors.lastname: Jallo
authors.forename: C
authors.initials: C
authors.lastname: Murphey
authors.forename: C N
authors.initials: CN
authors.lastname: Marti
authors.forename: E
authors.initials: E
authors.lastname: Godbold
authors.forename: R H
authors.initials: RH
authors.lastname: Pickler
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D006630:Hispanic or Latino; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein / Q000097:blood*; D016753:Interleukin-10 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011262:Pregnancy Trimester, Second / Q000208:ethnology*; D047928:Premature Birth / Q000175:diagnosis / Q000208:ethnology*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D053590:Interleukin 1 Receptor Antagonist Protein; D015850:Interleukin-6; D016753:Interleukin-10