title: [Dynamic change study of dermatitis medicamentosa-like of trichloroethylene patients with liver damage].
abstract: OBJECTIVE
  Observing the dynamic change characteristics of serum liver function indexes in occupational dermatitis medicamentosa-like of trichloroethylene patients with liver damage, we can underlie for guiding therapy, prognosis and mechanism of dermatitis medicamentosa-like of trichloroethylene patients with liver damage.
  
  
  METHODS
  We collected serum of 10 cases of occupational dermatitis medicamentosa-like of trichloro-ethylene patients with liver damage from different time points since they were hospitalized, using automatic biochemistry analyzer to detect total protein (TP), albumin (ALB), total bilirubin (TBIL), direct bilirubin (DBIL), indirect bilirubin (IBIL), alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transpeptidase (GGT), alkaline phosphatase (ALP), albumin/globulin ratio etc 11 liver function biochemical indicators. We used Excel to establish database, professional drawing software gnuplot to draw dynamic variation diagram of each index.
  
  
  RESULTS
  The variation range of 11 liver function indexes of 10 cases was TP 43.2-74.2 g/L, ALB 24.6-44.6 g/L, A/G 0.77-2.10, TBIL 3.7-268.2 umol/L, DBIL 1.0-166.0 umol/L, IBIL 2.4 -167.5 umol/L, ALT 11-5985 U/L, AST 14-5586 U/L, GGT 15-1500 U/L, ALP 35-309 U/L, S/L 0.07-1.94, respectively. TBIL, DBIL, ALT, AST, GGT, ALP concentration significantly increased, especially ALT, AST, GGT, ALT topped 5985 U/L, AST topped 5586 U/L, GGT topped 1500 U/L. But TP, ALB and S/L significantly decreased, TP lowest to 43.2 g/L, S/L lowest to 0.07. A/G basically remained unchanged, but IBIL didn't change regularly.
  
  
  CONCLUSIONS
  The early liver damage in dermatitis medicamentosa-like of trichloroethylene patients was serious, and repeatedly attacked, so we should lead to enough attention to the clinical work and prevention. This also provided the basis for studying the mechanism of trichloroethylene poisoning.
authors.affiliation: School of Medicine, Hunan Normal University, Changsha 410006, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Yan-fang
authors.initials: YF
authors.lastname: Zhang
authors.forename: Zhi-min
authors.initials: ZM
authors.lastname: Zhang
authors.forename: Pei-mao
authors.initials: PM
authors.lastname: Li
authors.forename: Xiao-dong
authors.initials: XD
authors.lastname: Jiang
authors.forename: Gui-feng
authors.initials: GF
authors.lastname: Zhou
authors.forename: Jian-jun
authors.initials: JJ
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000328:Adult; D001663:Bilirubin / Q000097:blood*; D009783:Dermatitis, Occupational / Q000097:blood / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008099:Liver / Q000201:enzymology / Q000503:physiopathology*; D008111:Liver Function Tests; D008297:Male; D014241:Trichloroethylene; D055815:Young Adult
chemical_list: D014241:Trichloroethylene; D001663:Bilirubin