title: Congenital disorders of glycosylation.
abstract: Congenital disorders of glycosylation (CDG) are a group of disorders involving a defect in the synthesis of oligosaccharides. Oligosaccharides are fundamental for protein stability and cellular communication and are present in almost every cell in the human body. A defect in the synthesis of oligosaccharides can result in multisystemic effects. Congenital disorders of glycosylation are classified into type I and type II disorders, each with subgroup classifications. All CDGs are autosomal recessive disorders, with CDG type I being the most common. This article will explore both types of CDG, their clinical presentation, diagnosis, and management.
authors.affiliation: Women's Hospital, Greensboro, North Carolina 27408, USA. woodsland@yahoo.com
authors.forename: Amanda G
authors.initials: AG
authors.lastname: Woods
authors.forename: Christopher W
authors.initials: CW
authors.lastname: Woods
authors.forename: Timothy M
authors.initials: TM
authors.lastname: Snow
mesh_terms: D018981:Congenital Disorders of Glycosylation / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics / Q000628:therapy; D006801:Humans; D009732:Nursing Care; D009844:Oligosaccharides / Q000378:metabolism*
chemical_list: D009844:Oligosaccharides