title: Development of a quercetin-loaded nanostructured lipid carrier formulation for topical delivery.
abstract: The main objective of this study was to evaluate the potential of quercetin-loaded nanostructured lipid carriers (QT-NLCs) as a topical delivery system. QT-NLCs were prepared by the method of emulsion evaporation-solidification at low temperature. The average entrapment efficiency and drug loading of the optimized QT-NLCs were 89.95 ± 0.16% and 3.05 ± 0.01%, respectively. Under the transmission electron microscope, the nanoparticles were spherically shaped. The average particle size was 215.2 nm, the zeta potential was -20.10 ± 1.22 mV and pH value of QT-NLCs system was 4.65. Topical delivery of QT in the form of NLCs was investigated in vitro and in vivo. The results showed that QT-NLCs could promote the permeation of QT, increase the amount of QT retention in epidermis and dermis, and enhance the effect of anti-oxidation and anti-inflammation exerted by QT. Then the mechanism of NLCs for facilitating drug penetration was further investigated through histological sections. In conclusion, NLCs could be a promising vehicle for topical delivery of QT.
authors.affiliation: Department of Pharmaceutics, College of Pharmacy, Shandong University, Jinan 250012, China.
authors.forename: Guo
authors.initials: G
authors.lastname: Chen-yu
authors.forename: Yang
authors.initials: Y
authors.lastname: Chun-fen
authors.forename: Li
authors.initials: L
authors.lastname: Qi-lu
authors.forename: Tan
authors.initials: T
authors.lastname: Qi
authors.forename: Xi
authors.initials: X
authors.lastname: Yan-wei
authors.forename: Liu
authors.initials: L
authors.lastname: Wei-na
authors.forename: Zhai
authors.initials: Z
authors.lastname: Guang-xi
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004195:Disease Models, Animal; D004337:Drug Carriers; D004339:Drug Compounding; D004487:Edema / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D016166:Free Radical Scavengers / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism; D008055:Lipids / Q000737:chemistry*; D008297:Male; D051379:Mice; D046529:Microscopy, Electron, Transmission; D049329:Nanostructures; D036103:Nanotechnology; D010316:Particle Size; D010539:Permeability; D011794:Quercetin / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism; D012867:Skin / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D012869:Skin Absorption; D012995:Solubility; D013481:Superoxides / Q000737:chemistry; D013678:Technology, Pharmaceutical; D013696:Temperature; D014992:Xylenes
chemical_list: D000893:Anti-Inflammatory Agents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D016166:Free Radical Scavengers; D008055:Lipids; D014992:Xylenes; D013481:Superoxides; D011794:Quercetin