title: Stability of extemporaneously prepared 0.5-percent caspofungin eye drops: a potential cost-savings exercise.
abstract: While the successful use of topical caspofungin for patients has been reported, topical caspofungin is not commercially available and its stability is unknown, limiting its usefulness in treating fungal keratitis. Caspofungin (0.5%) eye drops were aseptically prepared, and the concentrations were measured using a validated high-performance liquid chromatography (HPLC) analysis. The preparations remained stable for 28 days under refrigerated condition but not at 25.0 °C. Our study supports the cost-saving use of caspofungin eye drops in the clinical setting.
authors.affiliation: Centre for Medicine Use and Safety, Faculty of Pharmacy and Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
authors.forename: Chin Fen
authors.initials: CF
authors.lastname: Neoh
authors.forename: Jovan
authors.initials: J
authors.lastname: Jacob
authors.forename: Lok
authors.initials: L
authors.lastname: Leung
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.forename: Angela
authors.initials: A
authors.lastname: Stathopoulos
authors.forename: Kay
authors.initials: K
authors.lastname: Stewart
authors.forename: David C M
authors.initials: DC
authors.lastname: Kong
mesh_terms: D000077336:Caspofungin; D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D004356:Drug Storage / Q000191:economics / Q000379:methods; D054714:Echinocandins; D055666:Lipopeptides; D009883:Ophthalmic Solutions
chemical_list: D054714:Echinocandins; D055666:Lipopeptides; D009883:Ophthalmic Solutions; D000077336:Caspofungin