title: The type II secretion system: biogenesis, molecular architecture and mechanism.
abstract: Many gram-negative bacteria use the sophisticated type II secretion system (T2SS) to translocate a wide range of proteins from the periplasm across the outer membrane. The inner-membrane platform of the T2SS is the nexus of the system and orchestrates the secretion process through its interactions with the periplasmic filamentous pseudopilus, the dodecameric outer-membrane complex and a cytoplasmic secretion ATPase. Here, recent structural and biochemical information is reviewed to describe our current knowledge of the biogenesis and architecture of the T2SS and its mechanism of action.
authors.affiliation: Department of Biochemistry and Biomolecular Structure Center, University of Washington, Seattle, Washington 98195, USA.
authors.forename: Konstantin V
authors.initials: KV
authors.lastname: Korotkov
authors.forename: Maria
authors.initials: M
authors.lastname: Sandkvist
authors.forename: Wim G J
authors.initials: WG
authors.lastname: Hol
mesh_terms: D001426:Bacterial Proteins / Q000737:chemistry / Q000378:metabolism; D058947:Bacterial Secretion Systems; D006090:Gram-Negative Bacteria / Q000737:chemistry* / Q000378:metabolism*; D026901:Membrane Transport Proteins / Q000737:chemistry / Q000378:metabolism; D008954:Models, Biological; D008956:Models, Chemical; D046912:Multiprotein Complexes / Q000737:chemistry / Q000378:metabolism
chemical_list: D001426:Bacterial Proteins; D058947:Bacterial Secretion Systems; D026901:Membrane Transport Proteins; D046912:Multiprotein Complexes