title: Normal and system lupus erythematosus red blood cell interactions studied by double trap optical tweezers: direct measurements of aggregation forces.
abstract: Direct measurements of aggregation forces in piconewton range between two red blood cells in pair rouleau are performed under physiological conditions using double trap optical tweezers. Aggregation and disaggregation properties of healthy and pathologic (system lupus erythematosis) blood samples are analyzed. Strong difference in aggregation speed and behavior is revealed using the offered method which is proposed to be a promising tool for SLE monitoring at single cell level.
authors.affiliation: Lomonosov Moscow State University, Faculty of Physics, Moscow 119991, Russia.
authors.forename: Maria D
authors.initials: MD
authors.lastname: Khokhlova
authors.forename: Eugeny V
authors.initials: EV
authors.lastname: Lyubin
authors.forename: Alexander G
authors.initials: AG
authors.lastname: Zhdanov
authors.forename: Sophia Yu
authors.initials: SY
authors.lastname: Rykova
authors.forename: Irina A
authors.initials: IA
authors.lastname: Sokolova
authors.forename: Andrey A
authors.initials: AA
authors.lastname: Fedyanin
mesh_terms: D002478:Cells, Cultured; D004867:Equipment Design; D019544:Equipment Failure Analysis; D004903:Erythrocyte Aggregation; D004912:Erythrocytes; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000503:physiopathology*; D052898:Optical Tweezers