title: How the Hodgkin-Huxley equations inspired the Cardiac Physiome Project.
abstract: Early modelling of cardiac cells (1960-1980) was based on extensions of the Hodgkin-Huxley nerve axon equations with additional channels incorporated, but after 1980 it became clear that processes other than ion channel gating were also critical in generating electrical activity. This article reviews the development of models representing almost all cell types in the heart, many different species, and the software tools that have been created to facilitate the cardiac Physiome Project.
authors.affiliation: Department of Physiology, Anatomy & Genetics, University of Oxford, Oxford OX1 3PT, UK. denis.noble@dpag.ox.ac.uk
authors.forename: Denis
authors.initials: D
authors.lastname: Noble
authors.forename: Alan
authors.initials: A
authors.lastname: Garny
authors.forename: Penelope J
authors.initials: PJ
authors.lastname: Noble
mesh_terms: D000818:Animals; D006321:Heart / Q000502:physiology*; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D008954:Models, Biological