title: Focus issue: TOR signaling, a tale of two complexes.
abstract: Through its association with two distinct protein complexes, target of rapamycin (TOR) complex 1 (TORC1) and TOR complex 2 (TORC2), the kinase TOR coordinates cellular growth with cell cycles, growth factors, and nutrients. The interconnected TOR signaling network participates in various physiological and pathophysiological conditions, such as aging, stem cell renewal, cell specification, and carcinogenesis; therefore, understanding the details of this system may yield new ways to promote longer, healthier living. This issue provides an overview of research on TOR signaling that has emerged since the issue Science Signaling devoted to this topic in 2009.
authors.forename: Nancy R
authors.initials: NR
authors.lastname: Gough
mesh_terms: D002468:Cell Physiological Phenomena; D006801:Humans; D046912:Multiprotein Complexes / Q000378:metabolism; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism
chemical_list: C500984:CRTC1 protein, human; C493245:CRTC2 protein, human; D046912:Multiprotein Complexes; D014157:Transcription Factors; D058570:TOR Serine-Threonine Kinases