title: A double-blind, randomized, clinical trial on the antileishmanial activity of a Morinda citrifolia (Noni) stem extract and its major constituents.
abstract: A controlled study was conducted to determine the efficiency of a topical ointment prepared from the stem extract of Morinda citrifolia against cutaneous leishmaniasis. Similarly, the in vitro antileishmanial activity of morindicone and morinthone isolated from the extract were investigated against Leishmania major. These compounds displayed good activity. Out of 40 patients, 50% showed an excellent response and 30% exhibited good improvement.
authors.affiliation: Balochistan University of Information Technology, Engineering and Management Sciences, Quetta, Pakistan. fouzia.sattar@buitms.edu.pk
authors.forename: Fouzia A
authors.initials: FA
authors.lastname: Sattar
authors.forename: Fayaz
authors.initials: F
authors.lastname: Ahmed
authors.forename: Nadeem
authors.initials: N
authors.lastname: Ahmed
authors.forename: Samina A
authors.initials: SA
authors.lastname: Sattar
authors.forename: Muhammad A K
authors.initials: MA
authors.lastname: Malghani
authors.forename: Muhammad I
authors.initials: MI
authors.lastname: Choudhary
mesh_terms: D000293:Adolescent; D000328:Adult; D000880:Anthraquinones / Q000737:chemistry / Q000494:pharmacology; D000981:Antiprotozoal Agents / Q000737:chemistry / Q000627:therapeutic use*; D002648:Child; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D018320:Leishmania major / Q000187:drug effects; D016773:Leishmaniasis, Cutaneous / Q000188:drug therapy* / Q000469:parasitology; D008297:Male; D008875:Middle Aged; D015394:Molecular Structure; D032066:Morinda / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry / Q000627:therapeutic use*; D018547:Plant Stems / Q000737:chemistry*; D044004:Xanthones / Q000737:chemistry / Q000494:pharmacology; D055815:Young Adult
chemical_list: D000880:Anthraquinones; D000981:Antiprotozoal Agents; D010936:Plant Extracts; D044004:Xanthones; C523370:morindicone; C523371:morinthone