title: Highly efficient asymmetric Mannich reaction of dialkyl α-diazomethylphosphonates with N-carbamoyl imines catalyzed by chiral Brønsted acids.
abstract: An efficient method involving the first use of chiral phosphoric acids as catalysts in the asymmetric Mannich reaction of dialkyl diazomethylphosphonates and N-carbamoyl imines is developed. With only 0.1 mol % catalyst 1f, the reaction proceeded smoothly and produced the corresponding β-amino-α-diazophosphonate with up to 97% yield and >99% ee.
authors.affiliation: School of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China.
authors.forename: Hui
authors.initials: H
authors.lastname: Zhang
authors.forename: Xiaojing
authors.initials: X
authors.lastname: Wen
authors.forename: Lihua
authors.initials: L
authors.lastname: Gan
authors.forename: Yungui
authors.initials: Y
authors.lastname: Peng