title: Kinetics of single and dual infection of calves with an Asian atypical bovine pestivirus and a highly virulent strain of bovine viral diarrhoea virus 1.
abstract: Atypical bovine pestiviruses related to bovine viral diarrhoea virus (BVDV) have recently been detected in cattle from South America, Asia and Europe. The purpose of this study was to compare the clinical and virological aspects of dual infection with BVDV-1 (Horton 916) and an Asian atypical bovine pestivirus (Th/04_KhonKaen) in naïve calves, in comparison to single infections. Milder clinical signs were observed in the animals infected with single Th/04_KhonKaen strain. Leukocytopenia and lymphocytopenia were observed in all infected groups at a similar level which correlated with the onset of viraemia. Co-infection with both viruses led to prolonged fever in comparison to single strain inoculated groups and simultaneous replication of concurrent viruses in blood and in the upper respiratory tract. Following the infections all the calves seroconverted against homologous strains. Atypical pestiviruses pose a serious threat to livestock health and BVDV eradication, since they may have the potential to be widely spread in cattle populations without being detected and differentiated from other BVDV infections.
authors.affiliation: Department of Clinical Sciences, Swedish University of Agricultural Sciences (SLU), BOX 7054, SE-750 07 Uppsala, Sweden. m.larska@piwet.pulawy.pl
authors.forename: Magdalena
authors.initials: M
authors.lastname: Larska
authors.forename: Mirosław P
authors.initials: MP
authors.lastname: Polak
authors.forename: Victor
authors.initials: V
authors.lastname: Riitho
authors.forename: Rebecca
authors.initials: R
authors.lastname: Strong
authors.forename: Sándor
authors.initials: S
authors.lastname: Belák
authors.forename: Stefan
authors.initials: S
authors.lastname: Alenius
authors.forename: Åse
authors.initials: Å
authors.lastname: Uttenthal
authors.forename: Lihong
authors.initials: L
authors.lastname: Liu
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology*; D001208:Asia; D001912:Bovine Virus Diarrhea-Mucosal Disease / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology; D002417:Cattle; D060085:Coinfection; D001908:Diarrhea Viruses, Bovine Viral / Q000235:genetics* / Q000302:isolation & purification / Q000472:pathogenicity; D005060:Europe; D008297:Male; D012720:Severity of Illness Index; D014766:Viremia / Q000175:diagnosis* / Q000235:genetics / Q000276:immunology
chemical_list: D000914:Antibodies, Viral