title: Anxiolytic and antidepressant effects of aqueous tincture of the aerial part of Myosotis arvensis.
abstract: Experiments on outbred albino mice showed a significant anxiolytic effect of aqueous tincture of the aerial part of Myosotis arvensis (L.) (Boraginaceae) in a single daily dose of 0.5 ml/kg. In a dose of 2 ml/kg, the tincture of M. arvensis aerial part exhibited an anxiolytic and antidepressant effect. In contrast to phenazepam, aqueous tincture of M. arvensis did not inhibit exploratory and motor activities.
authors.affiliation: Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia.
authors.forename: N Yu
authors.initials: NY
authors.lastname: Polomeyeva
authors.forename: R V
authors.initials: RV
authors.lastname: Gurto
authors.forename: O S
authors.initials: OS
authors.lastname: Bryushinina
authors.forename: V A
authors.initials: VA
authors.lastname: Slepichev
authors.forename: A V
authors.initials: AV
authors.lastname: Kaigorodtsev
authors.forename: V Yu
authors.initials: VY
authors.lastname: Smirnov
authors.forename: N I
authors.initials: NI
authors.lastname: Suslov
authors.forename: V V
authors.initials: VV
authors.lastname: Udut
mesh_terms: D000818:Animals; D021461:Animals, Outbred Strains; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D000928:Antidepressive Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D001569:Benzodiazepines / Q000494:pharmacology; D028082:Boraginaceae / Q000737:chemistry*; D004353:Drug Evaluation, Preclinical; D008297:Male; D051379:Mice; D009068:Movement / Q000187:drug effects; D035261:Plant Components, Aerial / Q000737:chemistry*; D010936:Plant Extracts / Q000494:pharmacology*; D012149:Restraint, Physical; D012997:Solvents / Q000737:chemistry; D018709:Statistics, Nonparametric; D014867:Water / Q000737:chemistry
chemical_list: D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D010936:Plant Extracts; D012997:Solvents; D014867:Water; D001569:Benzodiazepines; C017928:phenazepam