title: Serum myeloperoxidase activity and oxidative stress in patients with acute brucellosis.
abstract: OBJECTIVE
  The role of infection in the pathogenesis of atherosclerosis has been increasingly discussed. Previous studies have suggested that increased myeloperoxidase activity plays an important role in the pathogenesis of atherosclerosis. The aim of this study was to investigate the serum myeloperoxidase activity and catalase activity along with lipid hydroperoxide (LOOH) levels in patients with acute brucellosis.
  
  
  METHODS
  Thirty-two patients with brucellosis and 33 healthy controls were enrolled. Serum myeloperoxidase activity, catalase activity and LOOH levels were determined.
  
  
  RESULTS
  Serum myeloperoxidase activity and LOOH levels were significantly higher in patients with brucellosis than controls (p<0.05, p<0.001), while catalase activity were significantly lower (p<0.001). LOOH levels were found to be significantly positively correlated with MPO activity (r=0.297, p=0.016) in patients.
  
  
  CONCLUSIONS
  These results indicate that increased myeloperoxidase activity and decreased catalase activity is associated with increased oxidative stress, which may have a role in atherosclerotic processes in brucellosis patients.
authors.affiliation: Yuzuncu Yıl University, Medical Faculty, Department of Infectious Disease and Clinical Microbiology, Van, Turkey.
authors.forename: Mustafa Kasım
authors.initials: MK
authors.lastname: Karahocagil
authors.forename: Mehmet
authors.initials: M
authors.lastname: Aslan
authors.forename: Mehmet Resat
authors.initials: MR
authors.lastname: Ceylan
authors.forename: Aytekin
authors.initials: A
authors.lastname: Cıkman
authors.forename: Mahmut
authors.initials: M
authors.lastname: Sunnetcioglu
authors.forename: Mehmet Emin
authors.initials: ME
authors.lastname: Kucukoglu
authors.forename: Abdullah
authors.initials: A
authors.lastname: Taskın
mesh_terms: D000208:Acute Disease; D000328:Adult; D050197:Atherosclerosis / Q000097:blood / Q000209:etiology; D002006:Brucellosis / Q000097:blood* / Q000150:complications; D002374:Catalase / Q000097:blood*; D005260:Female; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D018384:Oxidative Stress; D009195:Peroxidase / Q000097:blood*
chemical_list: D008054:Lipid Peroxides; D002374:Catalase; D009195:Peroxidase