title: Perspectives on cell reprogramming with RNA.
abstract: Recent advances in cell reprogramming have permitted the development of different stem cell lines and specific differentiated cell types using distinct technologies. Cell reprogramming is largely mediated by DNA and RNA. In this review, we explore the RNA-mediated cell reprogramming to induce specific target cell generation including stem cells, brain cells and cardiac cells. The ability of RNA populations to produce direct cell to cell phenotypic conversion is called Transcriptome Induced PhenotypeRemodeling (TIPeR). The theory and utility of RNA use for cellular reprogramming is explored in this review.
authors.affiliation: Department of Pharmacology, University of Pennsylvania Perelman School of Medicine, John Morgan Building, Room 37, 36th and Hamilton Walk, Philadelphia, PA 19104, USA.
authors.forename: Jai-Yoon
authors.initials: JY
authors.lastname: Sul
authors.forename: Tae Kyung
authors.initials: TK
authors.lastname: Kim
authors.forename: Jae Hee
authors.initials: JH
authors.lastname: Lee
authors.forename: James
authors.initials: J
authors.lastname: Eberwine
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002468:Cell Physiological Phenomena; D004247:DNA / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D012313:RNA / Q000235:genetics* / Q000378:metabolism*
chemical_list: D012313:RNA; D004247:DNA