title: Clinical, biometric and ultrasound assessment of the effects of daily use of a nutraceutical composed of lycopene, acerola extract, grape seed extract and Biomarine Complex in photoaged human skin.
abstract: BACKGROUND
  The use of nutraceuticals has become frequent in the cutaneous approach to photoaging.
  
  
  OBJECTIVE
  To assess the clinical efficacy of a nutraceutical product composed of lycopene, acerola extract, grape seed extract and Biomarine ComplexT in photoaged human skin.
  
  
  METHODS
  50 women, from 35 to 60 years of age, phototypes I to III, were assessed. For 120 days, they associated the nutraceutical product with the use of a sunscreen FPS15. On days 0 (D0), 30 (D30), 60 (D60), 90 (D90) and 120 (D120) they were evaluated and underwent Medical Assessments and Self-Assessment and cutaneous biometric analyses (corneometry, sebumetry and pH-metry) in the skin of the left zygomatic region and the upper medial side region of the left arm; on days 0 (D0), 30 (D30) and 120 (D120) the skin of the same regions was analyzed by ultrasound. On days 0 (D0) and 120 (D120) skin biopsies were performed in the areas where instrumental evaluation was performed (to evaluate collagen and elastic fibers).
  
  
  RESULTS
  There was an improvement of the general status of the skin of all volunteers by the Medical and Volunteer Self- Assessments; increased parameters of cutaneous hydration, reduction of pH, increasing of ultrasound density and a histological increment of collagen and elastic fibers (both on the face and arm); there was a reduction of seborrhea (only on the face)
  
  
  CONCLUSIONS
  The daily use of a nutraceutical product containing lycopene, acerola extract, grape seed extract and Biomarine ComplexT showed an important adjuvant effect to counteract skin photoaging.
authors.affiliation: Universidade Federal de São Paulo, Brazil. adilson_costa@hotmail.com
authors.forename: Adilson
authors.initials: A
authors.lastname: Costa
authors.forename: Lars
authors.initials: L
authors.lastname: Lindmark
authors.forename: Lúcia Helena Fávaro
authors.initials: LH
authors.lastname: Arruda
authors.forename: Elvira Cancio
authors.initials: EC
authors.lastname: Assumpção
authors.forename: Fernanda Sayuri
authors.initials: FS
authors.lastname: Ota
authors.forename: Margareth de Oliveira
authors.initials: Mde O
authors.lastname: Pereira
authors.forename: Stéphanie Selma Barros
authors.initials: SS
authors.lastname: Langen
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000627:therapeutic use*; D001205:Ascorbic Acid / Q000627:therapeutic use; D001938:Brazil; D002338:Carotenoids / Q000627:therapeutic use; D019587:Dietary Supplements; D005260:Female; D056604:Grape Seed Extract / Q000627:therapeutic use; D006801:Humans; D008137:Longitudinal Studies; D000077276:Lycopene; D029581:Malpighiaceae / Q000737:chemistry; D008875:Middle Aged; D012647:Self-Assessment; D015595:Skin Aging / Q000187:drug effects*
chemical_list: D000975:Antioxidants; D056604:Grape Seed Extract; D002338:Carotenoids; D001205:Ascorbic Acid; D000077276:Lycopene