title: A novel anticancer diterpenoid from Jatropha gossypifolia.
abstract: Jatropha gossypifolia root bark is used in ethnomedicine for bacterial infections and cancer of the lungs. Phytochemical investigation resulted in the isolation and characterization of a potent anticancer and novel lathyrane diterpenoid compound, abiodone, with an unusual methylene group. The structure of this novel compound was established by 1D, and 2D NMR spectroscopic experiments a nd confirmed by X-ray analysis.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Benin, Benin City, Nigeria, Edo State 30001. faloabi@uniben.edu
authors.forename: Abiodun
authors.initials: A
authors.lastname: Falodun
authors.forename: Udo
authors.initials: U
authors.lastname: Kragl
authors.forename: Serge-Mitherand Tengho
authors.initials: SM
authors.lastname: Touem
authors.forename: Alexander
authors.initials: A
authors.lastname: Villinger
authors.forename: Thomas
authors.initials: T
authors.lastname: Fahrenwaldt
authors.forename: Peter
authors.initials: P
authors.lastname: Langer
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry*; D006801:Humans; D031286:Jatropha / Q000737:chemistry*; D008175:Lung Neoplasms / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D024301:Plant Bark / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; C571547:abiodone; D002945:Cisplatin