title: Proteinase 3 anti-neutrophil cytoplasmic antibody (PR3-ANCA) positive IgG4-related retroperitoneal fibrosis: utility of PET-CT with 18F-fluorodeoxy glucose (FDG).
abstract: A 55-year-old man showed a serum creatinine level of 1.51 mg/dL, CRP of 0.79 mg/dL, and proteinase 3 anti-neutrophil cytoplasmic antibody (PR3-ANCA) of 43.9 EU (normal range: below 10). The serum levels and ratios of IgG1, IgG2, IgG3, and IgG4 to total IgG were 1,570 mg/dL (49%), 1,190 mg/dL (37%), 82 mg/dL (3%), and 351 mg/dL (11%), respectively. Positron emission tomography and CT with (18)F-fluorodeoxyglucose (PET-CT) demonstrated retroperitoneal fibrosis. After a diagnosis of IgG4-related retroperitoneal fibrosis with PR3-ANCA was made, oral prednisolone improved serum creatinine and the titer of PR3-ANCA to normal levels, with no abnormal findings on PET-CT.
authors.affiliation: Department of Nephrology and Endocrinology, Kizawa Memorial Hospital, Japan.
authors.forename: Shie
authors.initials: S
authors.lastname: Kotani
authors.forename: Ryo
authors.initials: R
authors.lastname: Wakamatsu
authors.forename: Ayano
authors.initials: A
authors.lastname: Itoh
authors.forename: Kanyu
authors.initials: K
authors.lastname: Miyamoto
authors.forename: Masabumi
authors.initials: M
authors.lastname: Yoshino
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Takami
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ishihara
authors.forename: Naoto
authors.initials: N
authors.lastname: Miura
authors.forename: Shogo
authors.initials: S
authors.lastname: Banno
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Imai
mesh_terms: D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D003404:Creatinine / Q000097:blood; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male; D008875:Middle Aged; D064847:Multimodal Imaging; D053146:Myeloblastin / Q000276:immunology*; D049268:Positron-Emission Tomography; D011239:Prednisolone / Q000627:therapeutic use; D019275:Radiopharmaceuticals; D012185:Retroperitoneal Fibrosis / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000276:immunology*; D014057:Tomography, X-Ray Computed
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic; D007074:Immunoglobulin G; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D011239:Prednisolone; D003404:Creatinine; D053146:Myeloblastin