title: Porencephaly in a cynomolgus monkey ( macaca fascicularis ).
abstract: Porencephaly was observed in a female cynomolgus monkey (Macaca fascicularis) aged 5 years and 7 months. The cerebral hemisphere exhibited diffuse brownish excavation with partial defects of the full thickness of the hemispheric wall, and it constituted open channels between the lateral ventricular system and arachnoid space. In addition, the bilateral occipital lobe was slightly atrophied. Histopathologically, fibrous gliosis was spread out around the excavation area and its periphery. In the roof tissue over the cavity, small round cells were arranged in the laminae. They seemed to be neural or glial precursor cells because they were positive for Musashi 1 and negative for NeuN and GFAP. In the area of fibrous gliosis, hemosiderin or lipofuscin were deposited in the macrophages, and activated astroglias were observed extensively around the excavation area.
authors.forename: Chika
authors.initials: C
authors.lastname: Hirowatari
authors.forename: Rinya
authors.initials: R
authors.lastname: Kodama
authors.forename: Yuji
authors.initials: Y
authors.lastname: Sasaki
authors.forename: Yohei
authors.initials: Y
authors.lastname: Tanigawa
authors.forename: Junko
authors.initials: J
authors.lastname: Fujishima
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Yoshikawa
authors.forename: Kaori
authors.initials: K
authors.lastname: Yabuuchi
authors.forename: Yuki
authors.initials: Y
authors.lastname: Kuwamura
authors.forename: Kimiaki
authors.initials: K
authors.lastname: Hirakawa
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Kamimura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Maeda