title: Using non-steroidal anti-inflammatory drugs around calving: maximizing comfort, productivity and fertility.
abstract: Non-steroidal anti-inflammatory drugs (NSAIDs) have analgesic, anti-inflammatory, anti-endotoxic and anti-pyretic effects in cattle. As such, they could be expected to have significant effects in cows and calves in the post-calving period. This review evaluates the published data on the use of NSAIDs in the dam and its calf after dystocia, the impact of NSAIDs on uterine involution, the restoration of ovarian function and prevention and treatment of the metritis complex, and the benefits of using NSAIDs in the recumbent cow. Overall, the published data are very limited, despite frequent use of NSAIDs by veterinarians in the post-calving cow, and the small number of published studies focus on blanket treatment of calving cows rather than targeted treatment after dystocia. Blanket treatment had no economic benefit; indeed, some studies reported adverse effects, such as pyrexia and increased risk of metritis. There is even less information on the value of treating calves with NSAIDs after dystocia, despite significant tissue damage which may benefit from NSAID use. Appreciably more studies have evaluated the influence of NSAIDs on uterine and ovarian function, but clinical relevance is limited. In cows with a normal puerperium, prolonged treatment with NSAIDs may slow the restoration of normal function, but most reported studies are small and use NSAIDs more frequently and for longer periods than is common in general practice. The evidence of a clinical benefit in cows with puerperal disease is limited and equivocal, and the evidence base for the use of NSAIDs in the treatment of recumbent cows is also small, even though an expert panel concluded that NSAIDs were a key aspect of veterinary treatment of downer cows. The lack of evidence identified by this review supports the contention that NSAIDs are likely to be under-used and sub-optimally prescribed in the post calving period. Further research on the use of NSAIDs in the post-calving cow and calf is required.
authors.affiliation: Institute of Veterinary, Animal, Biomedical Sciences, Massey University, Palmerston North, New Zealand. r.laven@massey.ac.nz
authors.forename: Richard
authors.initials: R
authors.lastname: Laven
authors.forename: Paul
authors.initials: P
authors.lastname: Chambers
authors.forename: Kevin
authors.initials: K
authors.lastname: Stafford
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000276:immunology / Q000502:physiology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy* / Q000503:physiopathology; D004420:Dystocia / Q000188:drug therapy / Q000503:physiopathology / Q000662:veterinary*; D005260:Female; D036801:Parturition / Q000187:drug effects; D058725:Peripartum Period / Q000187:drug effects; D049590:Postpartum Period / Q000187:drug effects; D011247:Pregnancy; D011644:Puerperal Disorders / Q000188:drug therapy / Q000503:physiopathology / Q000662:veterinary*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal