title: Discoidin discoveries.
abstract: In this issue of Structure, Carafoli et al. investigate the mode of antibody-mediated inhibition of the discoidin domain receptor 1 (DDR1). These studies also provide new insight into activation of the DDRs, which are unique among receptor tyrosine kinases in the composition of their extracellular regions.
authors.affiliation: Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. ferguso2@mail.med.upenn.edu
authors.forename: Kathryn M
authors.initials: KM
authors.lastname: Ferguson