title: Effect of the uncharged imidazolium moiety in adenine on endothelium-independent relaxation in the contracted thoracic aorta of Sprague-Dawley rats.
abstract: Adenine had a concentration-dependent relaxation action on the phenylephrine-contracted aorta ring, with an EC(50) value of 0.40±0.12 mM. This effect was also observed in the endothelium-denuded aorta. Among the adenine analogues, N-methyladenine and benzimidazole still evoked an apparent relaxation effect, while 1-, 3- or 7-methyladenine and imidazole were no longer vasodilators. These findings demonstrate that the imino group from the uncharged imidazolium moiety in adenine played a key role in the relaxation of the contracted aorta.
authors.affiliation: Division of Bioresources and Biosciences, Faculty of Agriculture, Graduate School of Kyushu University, Fukuoka, Japan.
authors.forename: Shinji
authors.initials: S
authors.lastname: Tokuda
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Fukuda
authors.forename: Yutaro
authors.initials: Y
authors.lastname: Kobayashi
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Tanaka
authors.forename: Toshiro
authors.initials: T
authors.lastname: Matsui
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects* / Q000502:physiology; D001562:Benzimidazoles / Q000494:pharmacology; D007093:Imidazoles / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects* / Q000502:physiology; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000502:physiology; D010656:Phenylephrine / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013329:Structure-Activity Relationship; D046509:Tissue Culture Techniques; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D001562:Benzimidazoles; D007093:Imidazoles; D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents; D010656:Phenylephrine; C029899:imidazole; C059225:7-methyladenine; C031000:benzimidazole; D000225:Adenine