title: University of Kentucky Sanders-Brown healthy brain aging volunteers: donor characteristics, procedures and neuropathology.
abstract: Cognitively intact elderly research volunteers at the University of Kentucky have been recruited, followed longitudinally, and autopsied with extensive neuropathological evaluations since 1989. To date, the cohort has recruited 1,030 individuals with 552 participants being actively followed, 363 deceased, and 273 autopsied. An extensive database has been constructed with continuous updates that include textured clinical, neuropsychological, neuroimaging, and pathological information. The history, demographics, clinical observations, and pathological features of this research cohort are described. We also explain some of the evolving methodologies and the academic contributions that have been made due to this motivated group of older Kentuckians.
authors.affiliation: Department of Neurology and the Sanders-Brown Center on Aging, 303 Sanders-Brown Building, 800 S. Limestone, University of Kentucky, Lexington, USA. fascom@uky.edu
authors.forename: Frederick A
authors.initials: FA
authors.lastname: Schmitt
authors.forename: Peter T
authors.initials: PT
authors.lastname: Nelson
authors.forename: Erin
authors.initials: E
authors.lastname: Abner
authors.forename: Stephen
authors.initials: S
authors.lastname: Scheff
authors.forename: Gregory A
authors.initials: GA
authors.lastname: Jicha
authors.forename: Charles
authors.initials: C
authors.lastname: Smith
authors.forename: Gregory
authors.initials: G
authors.lastname: Cooper
authors.forename: Marta
authors.initials: M
authors.lastname: Mendiondo
authors.forename: Deborah D
authors.initials: DD
authors.lastname: Danner
authors.forename: Linda J
authors.initials: LJ
authors.lastname: Van Eldik
authors.forename: Allison
authors.initials: A
authors.lastname: Caban-Holt
authors.forename: Mark A
authors.initials: MA
authors.lastname: Lovell
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Kryscio
mesh_terms: D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology*; D001344:Autopsy; D001921:Brain / Q000473:pathology*; D016208:Databases, Factual; D005260:Female; D006801:Humans; D007629:Kentucky; D008297:Male; D014019:Tissue Donors