title: High prevalence of high grade anal intraepithelial neoplasia in HIV-infected women screened for anal cancer.
abstract: There is no consensus on optimal screening for anal cancer (AC) in HIV+ women. Seven hundred fifteen unique asymptomatic women in a high-prevalence HIV+ community were screened for AC with anal cytology and triage to high-resolution anoscopy after routine screening was implemented in a large urban hospital system. Of these, 75 (10.5%) had an abnormal anal cytology and 29 (38.7%) of those with an abnormality had high-grade anal intraepithelial neoplasia (AIN). Women with poorly controlled HIV were significantly more likely to have high-grade AIN (P = 0.03). Given the high rate of AIN in screened HIV-infected women, routine AC screening in all HIV-infected women should be strongly considered.
authors.affiliation: Department of Obstetrics and Gynecology and Women's Health, Montefiore Medical Center, Bronx, NY 10461, USA.
authors.forename: June Y
authors.initials: JY
authors.lastname: Hou
authors.forename: David
authors.initials: D
authors.lastname: Smotkin
authors.forename: Robert
authors.initials: R
authors.lastname: Grossberg
authors.forename: Mark
authors.initials: M
authors.lastname: Suhrland
authors.forename: Rebecca
authors.initials: R
authors.lastname: Levine
authors.forename: Harriet O
authors.initials: HO
authors.lastname: Smith
authors.forename: Abdissa
authors.initials: A
authors.lastname: Negassa
authors.forename: Thomas C
authors.initials: TC
authors.lastname: McAndrew
authors.forename: Mark H
authors.initials: MH
authors.lastname: Einstein
mesh_terms: D000328:Adult; D001005:Anus Neoplasms / Q000453:epidemiology*; D002278:Carcinoma in Situ / Q000453:epidemiology*; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008875:Middle Aged; D015995:Prevalence