title: Insights into the mechanism of electron transfer and sodium translocation of the Na(+)-pumping NADH:quinone oxidoreductase.
abstract: Na(+)-NQR is a unique energy-transducing complex, widely distributed among marine and pathogenic bacteria. It converts the energy from the oxidation of NADH and the reduction of quinone into an electrochemical Na(+)-gradient that can provide energy for the cell. Na(+)-NQR is not homologous to any other respiratory protein but is closely related to the RNF complex. In this review we propose that sodium pumping in Na(+)-NQR is coupled to the redox reactions by a novel mechanism, which operates at multiple sites, is indirect and mediated by conformational changes of the protein. This article is part of a Special Issue entitled: 17th European Bioenergetics Conference (EBEC 2012).
authors.affiliation: Department of Biology, Rensselaer Polytechnic Institute, Troy, NY, USA. juareo@rpi.edu
authors.forename: Oscar
authors.initials: O
authors.lastname: Juárez
authors.forename: Blanca
authors.initials: B
authors.lastname: Barquera
mesh_terms: D020134:Catalytic Domain; D009247:NADH, NADPH Oxidoreductases / Q000737:chemistry / Q000378:metabolism; D009249:NADP / Q000737:chemistry / Q000378:metabolism; D010084:Oxidation-Reduction; D000254:Sodium-Potassium-Exchanging ATPase / Q000737:chemistry / Q000378:metabolism
chemical_list: D009249:NADP; D009247:NADH, NADPH Oxidoreductases; D000254:Sodium-Potassium-Exchanging ATPase