title: Liver failure caused by light chain deposition disease associated with multiple myeloma.
abstract: Acute liver failure is an unusual complication in multiple myeloma. Here, we report a case of multiple myeloma with light chain deposition disease (LCDD) that presented with progressive jaundice due to intrahepatic cholestasis. Diagnosis was made after liver biopsy that showed deposition of kappa light chains occupying perisinusoidal spaces. The patient developed encephalopathy and liver failure and died despite prompt initiation of dexamethasone therapy. The current prognosis of multiple myeloma patients with liver failure due to LCDD is dismal. New therapeutic strategies might improve this condition.
authors.affiliation: Hematology Department, La Plana Hospital, Catholic University of Valencia, Spain.
authors.forename: Armando
authors.initials: A
authors.lastname: Mena-Durán
authors.forename: Elia
authors.initials: E
authors.lastname: Muñoz Vicente
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Pareja Llorens
authors.forename: José
authors.initials: J
authors.lastname: Sanchis Cervera
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002780:Cholestasis, Intrahepatic / Q000209:etiology; D017809:Fatal Outcome; D006501:Hepatic Encephalopathy / Q000209:etiology; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000378:metabolism*; D017114:Liver Failure, Acute / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D008297:Male; D009101:Multiple Myeloma / Q000150:complications* / Q000276:immunology; D010265:Paraproteinemias / Q000150:complications / Q000276:immunology
chemical_list: D007145:Immunoglobulin kappa-Chains