title: Factor V Leiden: how great is the risk of venous thromboembolism?
abstract: The factor V Leiden mutation, the most common inherited cause of thrombophilia, causes a mild hypercoagulable state. We describe a 29-year-old man, heterozygous for factor V Leiden, who developed extensive pulmonary emboli with concomitant bilateral deep venous thrombosis, likely provoked by prolonged immobility during a car trip. We then review the diagnosis, therapy, screening, and prognosis of venous thromboembolism related to factor V Leiden.
authors.affiliation: Department of Medicine, Case Western Reserve University-St. Vincent Charity Medical Center, Cleveland, OH 44115, USA. Khaldoon.Shaheen@stvincentcharity.com
authors.forename: Khaldoon
authors.initials: K
authors.lastname: Shaheen
authors.forename: M Chadi
authors.initials: MC
authors.lastname: Alraies
authors.forename: Abdul Hamid
authors.initials: AH
authors.lastname: Alraiyes
authors.forename: Richard
authors.initials: R
authors.lastname: Christie
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D005165:Factor V / Q000235:genetics*; D005820:Genetic Testing; D006801:Humans; D008297:Male; D011379:Prognosis; D011655:Pulmonary Embolism / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D019851:Thrombophilia / Q000235:genetics*; D014463:Ultrasonography; D054556:Venous Thromboembolism / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D020246:Venous Thrombosis / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy
chemical_list: D000925:Anticoagulants; C095381:factor V Leiden; D005165:Factor V