title: Noninvasive prediction of intra-amniotic infection and/or inflammation in preterm premature rupture of membranes.
abstract: OBJECTIVE
  To develop a model based on noninvasive parameters to predict the probability of intra-amniotic infection and/or inflammation (IAI) in women with preterm premature rupture of membranes (PPROMs).
  
  
  METHODS
  Maternal blood was collected for determination of the C-reactive protein (CRP) level and white blood cell (WBC) count immediately after amniocentesis in 171 consecutive women with PPROMs. Intra-amniotic infection and/or inflammation was defined as a positive amniotic fluid (AF) culture and/or an elevated AF interleukin 6 level (≥2.6 ng/mL).
  
  
  RESULTS
  A risk score based on a model including maternal blood CRP, WBC, parity, and gestational age was calculated for each patient. The model was shown to have an adequate goodness of fit (P = .516), and the area under the receiver-operating characteristic curve was 0.848, indicating very good discrimination.
  
  
  CONCLUSIONS
  The noninvasive model based on maternal blood CRP, WBC, parity, and gestational age is highly predictive of IAI in women with PPROMs.
authors.affiliation: Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam, Korea. pkh0419@snubh.org
authors.forename: Kyo Hoon
authors.initials: KH
authors.lastname: Park
authors.forename: Shi Nae
authors.initials: SN
authors.lastname: Kim
authors.forename: Kyung Joon
authors.initials: KJ
authors.lastname: Oh
authors.forename: Sung Youn
authors.initials: SY
authors.lastname: Lee
authors.forename: Eun Ha
authors.initials: EH
authors.lastname: Jeong
authors.forename: Aeli
authors.initials: A
authors.lastname: Ryu
mesh_terms: D000328:Adult; D000649:Amniocentesis; D000653:Amniotic Fluid / Q000737:chemistry / Q000166:cytology / Q000382:microbiology*; D001424:Bacterial Infections / Q000175:diagnosis*; D002821:Chorioamnionitis / Q000175:diagnosis* / Q000382:microbiology; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000382:microbiology* / Q000473:pathology; D005865:Gestational Age; D006801:Humans; D015850:Interleukin-6 / Q000032:analysis; D007958:Leukocyte Count; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000175:diagnosis*; D012372:ROC Curve
chemical_list: D015850:Interleukin-6