title: First ruthenium(II) polypyridyl complex as a true molecular "light switch" for triplex RNA structure: [Ru(phen)2(mdpz)]2+ enhances the stability of Poly(U)·Poly(A)*Poly(U).
abstract: Stabilization of triple helical structures is extremely important for carrying out their biological  functions. Nucleic acid triple helices may be formed with DNA or RNA strands. In contrast to many studies in DNA, little has been reported concerning the recognition of the RNA triplex by transition-metal complexes. In this article, [Ru(phen)(2)(mdpz)](2+) (Ru1) is the first metal complex able to enhance the stability of the RNA triplex Poly(U)·Poly(A)*Poly(U) and serve as a prominent molecular "light switch" for the RNA triplex.
authors.affiliation: Key Lab of Environment-friendly Chemistry and Application in Ministry of Education, Xiangtan University, Xiangtan 411105, People's Republic of China. lfwyxh@yahoo.com.cn
authors.forename: Li-Feng
authors.initials: LF
authors.lastname: Tan
authors.forename: Jing
authors.initials: J
authors.lastname: Liu
authors.forename: Jian-Liang
authors.initials: JL
authors.lastname: Shen
authors.forename: Xiao-hua
authors.initials: XH
authors.lastname: Liu
authors.forename: Le-Li
authors.initials: LL
authors.lastname: Zeng
authors.forename: Lian-He
authors.initials: LH
authors.lastname: Jin
mesh_terms: D009690:Nucleic Acid Conformation; D009942:Organometallic Compounds / Q000737:chemistry*; D011131:Polyribonucleotides / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D012313:RNA / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*; D013696:Temperature
chemical_list: D009942:Organometallic Compounds; D011131:Polyribonucleotides; D011725:Pyridines; C063025:poly(U).poly(A).poly(U); D012313:RNA; D012428:Ruthenium; C023666:pyridine