title: A case of isoniazid-induced thrombocytopenia: recovery with immunoglobulin therapy.
abstract: Treatment for a 51-year-old man with pulmonary tuberculosis was initiated with isoniazid, rifampicin, ethambutol, and pyrazinamide, and discontinued after 3 weeks because of skin rash and itchiness. Isoniazid monotherapy was restarted after 2 weeks. Two days later, the platelet count decreased from 150 to 4×10(3)/mm(3). Despite platelet transfusion and oral corticosteroid treatment, the platelet count did not recover. However, after a 2-day administration of intravenous immunoglobulin, the platelet count recovered to 209×10(3)/mm(3). This report describes a case of isoniazid-induced thrombocytopenia that was reversed with intravenous immunoglobulin, thus highlighting the efficacy of this treatment for this rare condition.
authors.affiliation: Department of Internal Medicine, College of Medicine, Gyeongsang National University, Korea.
authors.forename: Eun Ju
authors.initials: EJ
authors.lastname: Lee
authors.forename: Seung Hun
authors.initials: SH
authors.lastname: Lee
authors.forename: You Eun
authors.initials: YE
authors.lastname: Kim
authors.forename: Seung Jun
authors.initials: SJ
authors.lastname: Lee
authors.forename: Yu Ji
authors.initials: YJ
authors.lastname: Cho
authors.forename: Yi Yeong
authors.initials: YY
authors.lastname: Jeong
authors.forename: Ho Cheol
authors.initials: HC
authors.lastname: Kim
authors.forename: Jong Deog
authors.initials: JD
authors.lastname: Lee
authors.forename: Young Sil
authors.initials: YS
authors.lastname: Hwang
mesh_terms: D000995:Antitubercular Agents / Q000009:adverse effects*; D006801:Humans; D007116:Immunization, Passive; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D007538:Isoniazid / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D013921:Thrombocytopenia / Q000097:blood / Q000139:chemically induced* / Q000628:therapy*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy
chemical_list: D000995:Antitubercular Agents; D016756:Immunoglobulins, Intravenous; D007538:Isoniazid