title: Lack of association between polymorphisms of thrombogenic genes and disease susceptibility in rheumatoid arthritis.
abstract: Rheumatoid arthritis (RA) is associated with increased mortality due to cardiovascular disease (CVD). Abnormalities in coagulation have been linked with CVD in general and RA population. The aim of our study is to determine whether particular single nucleotide polymorphisms thought to be involved in the regulation of coagulation are over-represented in patients with RA compared to controls. We compared the frequency of atherothrombotic polymorphisms (Factor V Leiden, fibrinogen G455A, prothrombin G20210A and plasminogen activator inhibitor 4G5G) in 322 RA patients [231 females, mean age 61.5 ± 12, median disease duration 10 years (IQR = 14)] with 441 local controls. No significant differences were observed in genotype or allele frequencies either between RA and controls or between the disease subgroups studied. Whereas these polymorphisms may be of importance at the level of individual patients, they are unlikely to be clinically important on a population basis.
authors.affiliation: Department of Rheumatology, Dudley Group of Hospitals NHS Foundation Trust, Russells Hall Hospital, Pensnett Road, Dudley, West Midlands, DY1 2HQ, UK.
authors.forename: Theodoros
authors.initials: T
authors.lastname: Dimitroulas
authors.forename: Karen M J
authors.initials: KM
authors.lastname: Douglas
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Smith
authors.forename: Vasilis F
authors.initials: VF
authors.lastname: Panoulas
authors.forename: George D
authors.initials: GD
authors.lastname: Kitas
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000235:genetics* / Q000276:immunology; D001323:Autoantibodies / Q000097:blood; D005165:Factor V / Q000235:genetics; D005260:Female; D005340:Fibrinogen / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010456:Peptides, Cyclic / Q000276:immunology; D015849:Plasminogen Inactivators / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D011516:Prothrombin / Q000235:genetics
chemical_list: D001323:Autoantibodies; D010456:Peptides, Cyclic; D015849:Plasminogen Inactivators; C487763:cyclic citrullinated peptide; C095381:factor V Leiden; D005165:Factor V; D011516:Prothrombin; D005340:Fibrinogen