title: Predictors of contractile recovery after revascularization in patients with anterior myocardial infarction who received thrombolysis.
abstract: BACKGROUND
  Identification of viable myocardium after myocardial infarction has gained paramount importance with the current progress in coronary revascularization.
  
  
  OBJECTIVE
  To explore the prognostic power of certain patient characteristics to predict myocardial contractile recovery after revascularization in patients presenting with acute anterior ST elevation myocardial infarction (STEMI) who received thrombolytic therapy.
  
  
  METHODS
  Seventy-three consecutive patients presenting with first acute anterior STEMI who had received thrombolytic therapy and had significant coronary stenosis or occlusion of the infarct-related artery amenable for revascularization were enrolled. All patients underwent echocardiographic assessment of regional wall motion and left ventricular ejection fraction. Patients underwent coronary revascularization by either percutaneous angioplasty or surgical bypass. Echocardiography was repeated two to three months following revascularization. Patients were classified into two groups: group 1 had evidence of contractile recovery after revascularization at follow-up echocardiography and group 2 had no such evidence of recovery.
  
  
  RESULTS
  Predictors of contractile recovery after revascularization included a shorter time from symptom onset to the institution of thrombolytic therapy, a lower baseline wall motion score index, the presence of grade 3 collaterals to the infarct-related artery and the use of beta-blockers. Instead, the presence of diabetes mellitus and a totally occluded infarct-related artery predicted poor contractile recovery.
  
  
  CONCLUSIONS
  Myocardial contractile recovery after revascularization in patients presenting with first acute anterior STEMI may be predicted by the absence of diabetes, a shorter time from symptom onset to thrombolytic therapy, the use of beta-blockers, a lower initial wall motion index score and the presence of collaterals to the infarct-related artery.
authors.affiliation: Cardiology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
authors.forename: Walaa
authors.initials: W
authors.lastname: Adel
authors.forename: Wail
authors.initials: W
authors.lastname: Nammas