title: Adolescent hyperactivity of offspring after maternal protein restriction during the second half of gestation and lactation periods in rats.
abstract: To clarify the effect of systemic growth retardation on behavior, pregnant rats were fed a synthetic diet with either a normal (20% casein) or low (10% casein) protein concentration from gestational day 10 to postnatal day (PND) 21 at weaning. Offspring were examined for sensory and reflex functions, detailed clinical observations, manipulative test, grip strength, motor activity and water-filled multiple T-maze test. Lowering trend in the air righting reflex index during lactation period and a decrease in grip strength on PND 72 were observed in the low protein diet group showing suppression of systemic growth. However, they were simply the reflection of delayed systemic growth, because parameters on impaired reflex function, disturbance of motor function and paralysis were unaffected. On the other hand, low protein diet resulted in increased motor activity in female offspring. Thus, malnutrition due to maternal protein restriction may cause adolescent hyperactivity.
authors.affiliation: Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, Tokyo, Japan.
authors.forename: Takumi
authors.initials: T
authors.lastname: Ohishi
authors.forename: Liyun
authors.initials: L
authors.lastname: Wang
authors.forename: Hirotoshi
authors.initials: H
authors.lastname: Akane
authors.forename: Ayako
authors.initials: A
authors.lastname: Shiraki
authors.forename: Akira
authors.initials: A
authors.lastname: Sato
authors.forename: Masanobu
authors.initials: M
authors.lastname: Uematsu
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Suzuki
authors.forename: Kunitoshi
authors.initials: K
authors.lastname: Mitsumori
authors.forename: Makoto
authors.initials: M
authors.lastname: Shibutani
mesh_terms: D000818:Animals; D018753:Diet, Protein-Restricted; D004195:Disease Models, Animal; D005260:Female; D005317:Fetal Growth Retardation / Q000503:physiopathology*; D018737:Hand Strength; D007774:Lactation / Q000502:physiology; D008297:Male; D009043:Motor Activity; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D012018:Reflex; D013216:Reflex, Startle