title: Prognostic factors in malignant pleural mesothelioma: a retrospective study.
abstract: OBJECTIVE
  The incidence of malignant pleural mesothelioma (MPM) in Japan is predicted to increase over the next few decades. Prognostic factors remain unclear although several studies have reported this disease. In this study, we examined the prognostic factors of MPM from single institution practice data and tested the scoring systems of past reports.
  
  
  METHODS
  We retrospectively obtained clinical data from the medical records of patients who were diagnosed with MPM from 1991 to 2010. The European Organization for Research and Treatment of Cancer prognostic score (EPS) was calculated.
  
  
  RESULTS
  We surveyed the records of 68 patients. Univariate analysis showed that significant prognostic factors were histological type, stage, performance status (PS), chemotherapy, and lactate dehydrogenase (LD). Multivariate analysis identified stage, PS and LD as independent prognostic factors. Low-risk group (EPS ≤1.27) survival was significantly better than that of the high-risk group (EPS >1.27) (17.0 months vs. 8.0 months; p=0.002).
  
  
  CONCLUSIONS
  Stage, PS and LD were demonstrated to be independent prognostic factors. An EPS >1.27 was still considered a poor prognosis indicator in the practice data of MPM.
authors.affiliation: Department of Thoracic Malignancy, Osaka Prefectural Medical Center for Respiratory and Allergic Diseases, Japan. suzukih@opho.jp
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Suzuki
authors.forename: Tomonori
authors.initials: T
authors.lastname: Hirashima
authors.forename: Masashi
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Norio
authors.initials: N
authors.lastname: Okamoto
authors.forename: Yuka
authors.initials: Y
authors.lastname: Matsuura
authors.forename: Motohiro
authors.initials: M
authors.lastname: Tamiya
authors.forename: Naoko
authors.initials: N
authors.lastname: Morishita
authors.forename: Kohei
authors.initials: K
authors.lastname: Okafuji
authors.forename: Takayuki
authors.initials: T
authors.lastname: Shiroyama
authors.forename: Osamu
authors.initials: O
authors.lastname: Morimura
authors.forename: Satomu
authors.initials: S
authors.lastname: Morita
authors.forename: Ichiro
authors.initials: I
authors.lastname: Kawase
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D007564:Japan / Q000453:epidemiology; D053208:Kaplan-Meier Estimate; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D008654:Mesothelioma / Q000188:drug therapy / Q000401:mortality* / Q000473:pathology / Q000503:physiopathology; D015999:Multivariate Analysis; D009367:Neoplasm Staging; D010997:Pleural Neoplasms / Q000188:drug therapy / Q000401:mortality* / Q000473:pathology / Q000503:physiopathology; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D007770:L-Lactate Dehydrogenase