title: [Expression and clinical significance of CD3,  CD4 and COX-2 in non-small cell lung cancer].
abstract: OBJECTIVE
  To study expression and clinical significance of CD3,  CD4 and COX-2 in non-small cell lung cancer (NSCLC).
  
  
  METHODS
  Expression of COX-2,  CD3 and CD4 was detected by immunohistochemical staining in 37 cases of NSCLC. The correlation of CD3,  CD4,  COX-2 expressions and overall survival(OS)  was evaluated with spearman rank correlation analysis.
  
  
  RESULTS
  The average surface density of CD3 and the average optical density of CD4 were significantly associated with OS of NSCLC patients after surgery (P<0.05). However,  both two densities of COX-2 were correlated with survival time of patients (P>0.05).
  
  
  CONCLUSIONS
  The expressions of CD3,  CD4 were significantly associated with OS of NSCLC patients.
authors.affiliation: Department of Medical Oncology,  PLA General Hospital,   Beijing 100853,  China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Zhao
authors.forename: Xiang
authors.initials: X
authors.lastname: Yan
authors.forename: Yan-Fang
authors.initials: YF
authors.lastname: Ju
authors.forename: Hai-Ming
authors.initials: HM
authors.lastname: Yu
authors.forename: Shun-Chang
authors.initials: SC
authors.lastname: Jiao
mesh_terms: D000328:Adult; D000368:Aged; D017252:CD3 Complex / Q000096:biosynthesis*; D015704:CD4 Antigens / Q000096:biosynthesis*; D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D051546:Cyclooxygenase 2 / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D016019:Survival Analysis
chemical_list: D017252:CD3 Complex; D015704:CD4 Antigens; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human