title: A randomized, placebo controlled study: EMLA in minor breast surgery.
abstract: OBJECTIVE
  Patients undergoing excision for breast lumps prefer general anesthesia or local anesthesia plus sedation, because of the fear of pain for local anesthesia alone. The aim of this study is to show the efficacy of an eutectic mixture of local anesthetic lignocaine and prilocaine (EMLA®) in these patients.
  
  
  METHODS
  This study has been designed randomized, placebo-controlled. Forty five patients undergoing excision for breast lumps were divided into three groups. The first group was administered local EMLA cream preoperatively (Group I, N.=15), the second group (Group II, N.=15) had no preoperative preparation and the third group was placebo group (Group III, N.=15). All groups underwent the operation under local anesthesia. Pain during the local anesthesia and three hours after the operation were assessed using the visual analog scale. The amount of local anesthetic used during the operation and the anesthetic need of patients after the operation were assessed.
  
  
  RESULTS
  When the three groups were compared, it was found that the intensity of pain in the group with EMLA was considerably lower during and after the operation (P<0.05). The amount of local anesthetic used during the operation was lower (P<0.05) and the need for post-operative analgesic was also less than the usual (P<0.05).
  
  
  CONCLUSIONS
  Topical EMLA use decreases the pain, provides per-operative and postoperative patient and physician comfort, improved patient's compliance, and simplifies the surgical procedure. This is the first study demonstrating that a topical anesthetic provides a non-invasive analgesia during benign breast mass excision.
authors.affiliation: Department of General Surgery, Okmeydanı Education and Research Hospital, Istanbul, Turkey. akanarzu@hotmail.com
authors.forename: A
authors.initials: A
authors.lastname: Akan
authors.forename: Y
authors.initials: Y
authors.lastname: Eryavuz
authors.forename: S
authors.initials: S
authors.lastname: Kamali
authors.forename: S
authors.initials: S
authors.lastname: Simşek
authors.forename: S
authors.initials: S
authors.lastname: Hot
authors.forename: R
authors.initials: R
authors.lastname: Bademci
mesh_terms: D000293:Adolescent; D000328:Adult; D000772:Anesthesia, Local; D019162:Anesthetics, Combined / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000601:surgery*; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000627:therapeutic use*; D000077442:Lidocaine, Prilocaine Drug Combination; D008875:Middle Aged; D011318:Prilocaine / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D019162:Anesthetics, Combined; D000077442:Lidocaine, Prilocaine Drug Combination; D011318:Prilocaine; D008012:Lidocaine