title: Iron sulfur cluster proteins and microbial regulation: implications for understanding tuberculosis.
abstract: All pathogenic and nonpathogenic microbes are continuously exposed to environmental or endogenous reactive oxygen and nitrogen species, which can critically effect survival and disease. Iron-sulfur [Fe-S] cluster containing prosthetic groups provide the microbial cell with a unique capacity to sense and transcriptionally respond to diatomic gases (e.g. NO and O2) and redox-cycling agents. Recent advances in our understanding of the mechanisms for how the FNR and SoxR [Fe-S] cluster proteins respond to NO and O2 have provided new insights into the biochemical mechanism of action of the Mycobacterium tuberculosis (Mtb) family of WhiB [Fe-S] cluster proteins. These insights have provided the basis for establishing a unifying paradigm for the Mtb WhiB family of proteins. Mtb is the etiological agent for tuberculosis (TB), a disease that affects nearly one-third of the world's population.
authors.affiliation: Department of Microbiology, University of Alabama at Birmingham, AL 35294, USA.
authors.forename: Vikram
authors.initials: V
authors.lastname: Saini
authors.forename: Aisha
authors.initials: A
authors.lastname: Farhana
authors.forename: Joel N
authors.initials: JN
authors.lastname: Glasgow
authors.forename: Adrie J C
authors.initials: AJ
authors.lastname: Steyn
mesh_terms: D001426:Bacterial Proteins / Q000378:metabolism; D006801:Humans; D007506:Iron-Sulfur Proteins / Q000235:genetics / Q000378:metabolism*; D005810:Multigene Family; D010084:Oxidation-Reduction; D013385:Succinate Dehydrogenase / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism; D014376:Tuberculosis / Q000378:metabolism* / Q000382:microbiology*
chemical_list: D001426:Bacterial Proteins; D007506:Iron-Sulfur Proteins; D014157:Transcription Factors; C070724:SoxR protein, Bacteria; D013385:Succinate Dehydrogenase