title: Biological activity of some derivatives of β-cyclodextrin.
abstract: New compounds of β-cyclodextrin containing covalently bound (conjugated) residues of acetylsalicylic and 1-(4-isobutylphenyl)-propionic acids were synthesized in the reaction of chlorides of the corresponding acids with β-cyclodextrin. We studied antiplatelet and antiphlogistic properties of these substances. It was shown that new compounds are comparable and in some cases are superior to the reference drugs acetylsalicylic acid and ibuprofen by anti-inflammatory and antiaggregant activities.
authors.affiliation: Amur State Medical Academy, Blagoveshchensk, Russia. batalova_ta@mail.ru
authors.forename: T A
authors.initials: TA
authors.lastname: Batalova
authors.forename: V A
authors.initials: VA
authors.lastname: Dorovskich
authors.forename: G I
authors.initials: GI
authors.lastname: Kurochkina
authors.forename: M K
authors.initials: MK
authors.lastname: Grachev
authors.forename: M L
authors.initials: ML
authors.lastname: Plastinin
authors.forename: A A
authors.initials: AA
authors.lastname: Sergievich
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use*; D001241:Aspirin / Q000737:chemistry; D004487:Edema / Q000188:drug therapy; D007052:Ibuprofen / Q000627:therapeutic use; D051379:Mice; D015394:Molecular Structure; D010974:Platelet Aggregation / Q000187:drug effects; D011422:Propionates / Q000737:chemistry; D013329:Structure-Activity Relationship; D047392:beta-Cyclodextrins / Q000737:chemistry*
chemical_list: D000893:Anti-Inflammatory Agents; D011422:Propionates; D047392:beta-Cyclodextrins; D001241:Aspirin; D007052:Ibuprofen