title: Antiproliferative activity of polygonaceae species from the Carpathian Basin against human cancer cell lines.
abstract: Aqueous and organic extracts of 27 selected species from five genera (Fallopia, Oxyria, Persicaria, Polygonum and Rumex) of the family Polygonaceae occurring in the Carpathian Basin were screened in vitro for antiproliferative activity against HeLa (cervix epithelial adenocarcinoma), A431 (skin epidermoid carcinoma) and MCF7 (breast epithelial adenocarcinoma) cells, using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. A total of 196 n-hexane, chloroform, 50% methanol or water extracts of different plant parts were investigated. It was found that extracts of Polygonum hydropiper, Rumex acetosa, Rumex alpinus, Rumex aquaticus, Rumex scutatus and Rumex thyrsiflorus at 10 or 30 µg/mL demonstrated substantial cell growth inhibitory activity (at least 50% inhibition of cell proliferation) against one or more cell lines. R. acetosa and R. thyrsiflorus proved to be the most active and are considered worthy of activity-guided phytochemical investigations.
authors.affiliation: Department of Pharmacognosy, University of Szeged, Eötvös u. 6, H-6720 Szeged, Hungary.
authors.forename: Ildikó
authors.initials: I
authors.lastname: Lajter
authors.forename: István
authors.initials: I
authors.lastname: Zupkó
authors.forename: Judit
authors.initials: J
authors.lastname: Molnár
authors.forename: Gusztáv
authors.initials: G
authors.lastname: Jakab
authors.forename: Lajos
authors.initials: L
authors.lastname: Balogh
authors.forename: Andrea
authors.initials: A
authors.lastname: Vasas
authors.forename: Judit
authors.initials: J
authors.lastname: Hohmann
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D006367:HeLa Cells; D006801:Humans; D010936:Plant Extracts / Q000494:pharmacology*; D019664:Polygonaceae / Q000737:chemistry*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts