title: Connectomics signatures of prenatal cocaine exposure affected adolescent brains.
abstract: Recent in vivo neuroimaging studies revealed that several brain networks are altered in prenatal cocaine exposure (PCE) affected adolescent brains. However, due to a lack of dense and corresponding cortical landmarks across individuals, the systematical alterations of functional connectivities in large-scale brain networks and the alteration of structural brain architecture in PCE affected brain are largely unknown. In this article, we adopted a newly developed data-driven strategy to build a large set of cortical landmarks that are consistent and corresponding across PCE adolescents and their matched controls. Based on these landmarks, we constructed large-scale functional connectomes and applied the well-established approaches of deriving genomics signatures in genome-wide gene expression studies to discover functional connectomics signatures for the characterization of PCE adolescent brains. Results derived from experimental data demonstrated that 10 structurally disrupted landmarks were identified in PCE, and more importantly, the discovered informative functional connectomics signatures among consistent landmarks distinctively differentiate PCE brains from their matched controls.
authors.affiliation: Department of Automatic Control, School of Automation, Northwestern Polytechnic University, Xi'an, China; Department of Computer Science and Bioimaging Research Center, The University of Georgia, Athens, Georgia.
authors.forename: Kaiming
authors.initials: K
authors.lastname: Li
authors.forename: Dajiang
authors.initials: D
authors.lastname: Zhu
authors.forename: Lei
authors.initials: L
authors.lastname: Guo
authors.forename: Zhihao
authors.initials: Z
authors.lastname: Li
authors.forename: Mary Ellen
authors.initials: ME
authors.lastname: Lynch
authors.forename: Claire
authors.initials: C
authors.lastname: Coles
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Hu
authors.forename: Tianming
authors.initials: T
authors.lastname: Liu
mesh_terms: D000293:Adolescent; D000465:Algorithms; D059925:Anatomic Landmarks / Q000473:pathology*; D001921:Brain / Q000187:drug effects* / Q000196:embryology / Q000254:growth & development; D016022:Case-Control Studies; D003042:Cocaine / Q000009:adverse effects*; D019970:Cocaine-Related Disorders / Q000503:physiopathology; D063132:Connectome; D005260:Female; D005500:Follow-Up Studies; D020869:Gene Expression Profiling; D006801:Humans; D008297:Male; D008431:Maternal-Fetal Exchange; D009419:Nerve Tissue Proteins / Q000096:biosynthesis / Q000235:genetics; D059906:Neuroimaging / Q000379:methods*; D010296:Parietal Lobe / Q000187:drug effects / Q000196:embryology / Q000254:growth & development; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology; D011297:Prenatal Exposure Delayed Effects / Q000473:pathology*
chemical_list: D009419:Nerve Tissue Proteins; D003042:Cocaine