title: Copper-mediated aerobic fluoroalkylation of arylboronic acids with fluoroalkyl iodides at room temperature.
abstract: A Cu-mediated ligandless aerobic fluoroalkylation of arylboronic acids under mild conditions is described for the first time. The reaction tolerates a wide range of functional groups, allowing for further transformation. Mechanistic studies suggest that [R(f)Cu] is the active Cu species that forms the desired perfluoroalkylarenes and that [R(f)Cu] is generated from [PhCu] by either an oxidative addition/reductive elimination mechanism or nucleophilic substitution via a halogen "ate" intermediate.
authors.affiliation: Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, PRC.
authors.forename: Qingqing
authors.initials: Q
authors.lastname: Qi
authors.forename: Qilong
authors.initials: Q
authors.lastname: Shen
authors.forename: Long
authors.initials: L
authors.lastname: Lu
mesh_terms: D000478:Alkylation; D001897:Boronic Acids / Q000737:chemistry*; D003300:Copper / Q000737:chemistry; D017611:Fluorine Compounds / Q000737:chemistry; D007454:Iodides / Q000737:chemistry; D010084:Oxidation-Reduction
chemical_list: D001897:Boronic Acids; D017611:Fluorine Compounds; D007454:Iodides; D003300:Copper