title: Stability of vaccinia-vectored recombinant oral rabies vaccine under field conditions: a 3-year study.
abstract: Rabies is an incurable zoonotic disease caused by rabies virus, a member of the rhabdovirus family. It is transmitted through the bite of an infected animal. Control methods, including oral rabies vaccination (ORV) programs, have led to a reduction in the spread and prevalence of the disease in wildlife. This study evaluated the stability of RABORAL, a recombinant vaccinia virus vaccine that is used in oral rabies vaccination programs. The vaccine was studied in various field microenvironments in order to describe its viability and facilitate effective baiting strategies. Field microenvironments influenced the stability of this vaccine in this study. This study emphasizes the importance of understanding how vaccines perform under varying field conditions in order to plan effective baiting strategies.
authors.affiliation: Center for Veterinary Biologics, Animal Plant Health Inspection Service, United States Department of Agriculture, Ames, Iowa 50010, USA.
authors.forename: Joseph R
authors.initials: JR
authors.lastname: Hermann
authors.forename: Alethea M
authors.initials: AM
authors.lastname: Fry
authors.forename: David
authors.initials: D
authors.lastname: Siev
authors.forename: Dennis
authors.initials: D
authors.lastname: Slate
authors.forename: Charles
authors.initials: C
authors.lastname: Lewis
authors.forename: Donna M
authors.initials: DM
authors.lastname: Gatewood
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000835:Animals, Wild; D004355:Drug Stability; D011818:Rabies / Q000517:prevention & control / Q000662:veterinary*; D011819:Rabies Vaccines / Q000008:administration & dosage / Q000737:chemistry / Q000276:immunology*; D014611:Vaccination / Q000379:methods / Q000662:veterinary; D014614:Vaccines, Synthetic / Q000008:administration & dosage / Q000737:chemistry / Q000276:immunology; D014615:Vaccinia
chemical_list: D011819:Rabies Vaccines; D014614:Vaccines, Synthetic