title: Impact of amyloid-β peptide (1-42) on voltage-gated ion currents in molluscan neurons.
abstract: Different types of voltage-gated ion currents were recorded in isolated neurons of snail Helix pomatia using the two-microelectrode voltage-clamp technique. Application of amyloid-β peptide (1-42, 1-10 μM) in the bathing solution did not change delayed rectifier K(+)-current and leakage current, but enhanced inactivation of Ca(2+)-current and blocked Ca(2+)-dependent K(+)-current.
authors.affiliation: Research Center of Neurology, Russian Academy of Medical Sciences, Moscow, Russia. soln@front.ru
authors.forename: E I
authors.initials: EI
authors.lastname: Solntseva
authors.forename: J V
authors.initials: JV
authors.lastname: Bukanova
authors.forename: E V
authors.initials: EV
authors.lastname: Marchenko
authors.forename: V G
authors.initials: VG
authors.lastname: Skrebitsky
mesh_terms: D016229:Amyloid beta-Peptides / Q000494:pharmacology*; D000818:Animals; D015220:Calcium Channels / Q000187:drug effects / Q000378:metabolism; D008974:Mollusca; D009474:Neurons / Q000187:drug effects*; D018408:Patch-Clamp Techniques; D024642:Potassium Channels, Voltage-Gated / Q000187:drug effects / Q000378:metabolism*
chemical_list: D016229:Amyloid beta-Peptides; D015220:Calcium Channels; D024642:Potassium Channels, Voltage-Gated