title: [PAIR-gynaecology: multi/interdisciplinary for gynecologic cancer research. Problems needed to be resolved].
abstract: Each year, 13,000 newly gynecologic cancers are diagnosed in France. Gynecologic cancers were specifically heterogeneous (localisations, histologic subgroups, age class, etc). This work was delineated for a national call dedicated to gynecologic cancers. This review reports the major needs in terms of scientific research dedicated to gynecologic cancers in the biologic, epidemiology, human and sociologic fields. For example, medico-economic strategies adapted to ethnosociologic context, specifically for cervix cancer, took important part of the epidemiologic research. Impact of gynecologic cancer in terms of symptoms and late effects, quality of life after treatments and fertility needs to be specifically explored. For fundamental research, molecular characterisation, biologic markers, impact of immunology and genetics represent the major part of the field need to be explored. Finally, therapeutic and diagnosis innovations, optimization of treatments strategies and development of predictive models in order to perform individual prediction taking into account several risk factors (clinical and molecular) to offer help in management of gynecologic cancers are required.
authors.affiliation: Université Lyon-I, centre Léon-Bérard, France. isabelle.ray-coquard@lyon.unicancer.fr
authors.forename: Isabelle
authors.initials: I
authors.lastname: Ray-Coquard
authors.forename: Franck
authors.initials: F
authors.lastname: Chauvin
authors.forename: Eric
authors.initials: E
authors.lastname: Leblanc
authors.forename: Christophe
authors.initials: C
authors.lastname: Caux
authors.forename: Hélène
authors.initials: H
authors.lastname: Hoarau
authors.forename: Franck
authors.initials: F
authors.lastname: Bonnetain
authors.forename: Véronique
authors.initials: V
authors.lastname: Christophe
authors.forename: Xavier
authors.initials: X
authors.lastname: Sastre-Garau
authors.forename: Gwendal
authors.initials: G
authors.lastname: Lazennec
authors.forename: Laurent
authors.initials: L
authors.lastname: Poulain
authors.forename: Christine
authors.initials: C
authors.lastname: Haie-Meder
authors.forename: Eric
authors.initials: E
authors.lastname: Pujade-Lauraine
authors.forename: Michel
authors.initials: M
authors.lastname: Salzet
authors.forename: Eric
authors.initials: E
authors.lastname: Deutsch
authors.forename: Mojgan
authors.initials: M
authors.lastname: Devouassoux
authors.forename: Frédérique
authors.initials: F
authors.lastname: Penault Llorca
authors.forename: Fabrice
authors.initials: F
authors.lastname: Lecuru
authors.forename: Sophie
authors.initials: S
authors.lastname: Taieb
authors.forename: Patrick
authors.initials: P
authors.lastname: Arveux
authors.forename: Charles
authors.initials: C
authors.lastname: Theillet
authors.forename: Florence
authors.initials: F
authors.lastname: Joly
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood; D035843:Biomedical Research; D004273:DNA, Neoplasm / Q000097:blood; D055088:Early Detection of Cancer; D016889:Endometrial Neoplasms / Q000473:pathology; D005260:Female; D005298:Fertility; D005602:France / Q000453:epidemiology; D005833:Genital Neoplasms, Female / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics / Q000276:immunology / Q000523:psychology / Q000628:therapy; D006801:Humans; D007157:Immunologic Surveillance / Q000276:immunology; D035683:MicroRNAs / Q000032:analysis; D010051:Ovarian Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000276:immunology / Q000473:pathology / Q000523:psychology / Q000628:therapy; D011788:Quality of Life; D012307:Risk Factors; D019529:Sexuality; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000276:immunology / Q000523:psychology / Q000628:therapy
chemical_list: D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm; D035683:MicroRNAs