title: Serum cholesterol reduction by feeding a high-cholesterol diet containing a lower-molecular-weight polyphenol fraction from peanut skin.
abstract: Feeding a high-cholesterol diet with a water-soluble peanut skin polyphenol fraction to rats reduced their plasma cholesterol level, with an increase in fecal cholesterol excretion. The hypocholesterolemic effect was greater with the lower-molecular-weight rather than higher-molecular-weight polyphenol fraction. This effect was possibly due to some oligomeric polyphenols which reduced the solubility of dietary cholesterol in intestinal bile acid-emulsified micelles.
authors.affiliation: Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture, Tokyo, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Tamura
authors.forename: Naoko
authors.initials: N
authors.lastname: Inoue
authors.forename: Akiko
authors.initials: A
authors.lastname: Shimizu-Ibuka
authors.forename: Miki
authors.initials: M
authors.lastname: Tadaishi
authors.forename: Toshichika
authors.initials: T
authors.lastname: Takita
authors.forename: Soichi
authors.initials: S
authors.lastname: Arai
authors.forename: Kiyoshi
authors.initials: K
authors.lastname: Mura
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D010367:Arachis / Q000737:chemistry*; D001647:Bile Acids and Salts / Q000378:metabolism; D002791:Cholesterol, Dietary / Q000008:administration & dosage / Q000097:blood; D059305:Diet, High-Fat; D005243:Feces / Q000737:chemistry; D005638:Fruit / Q000737:chemistry*; D007413:Intestinal Mucosa / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D059808:Polyphenols / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D051381:Rats; D012995:Solubility
chemical_list: D000924:Anticholesteremic Agents; D001647:Bile Acids and Salts; D002791:Cholesterol, Dietary; D010936:Plant Extracts; D059808:Polyphenols