title: Incarvilleatone, a new cyclohexylethanoid dimer from Incarvillea younghusbandii and its inhibition against nitric oxide (NO) release.
abstract: Incarvilleatone (1), an unprecedented dimeric cyclohexylethanoid analog with a racemic nature, was isolated from the whole plant of Incarvillea younghusbandii. HPLC chiral separation of 1 gave two enantiomers (-)-incarvilleatone and (+)-incarvilleatone. The structure of 1 was established by spectroscopic methods and single crystal X-ray diffraction. The absolute configurations of enantiomers were determined by quantum mechanical calculation. (-)-Incarvilleatone exhibited a potent inhibitory effect against NO production in LPS-induced RAW264.7 macrophages.
authors.affiliation: Department of Phytochemistry, School of Pharmacy, Second Military Medical University, 325 Guohe Road, Shanghai 200433, PR China.
authors.forename: Yan-Ping
authors.initials: YP
authors.lastname: Gao
authors.forename: Yun-Heng
authors.initials: YH
authors.lastname: Shen
authors.forename: Shou-De
authors.initials: SD
authors.lastname: Zhang
authors.forename: Jun-Mian
authors.initials: JM
authors.lastname: Tian
authors.forename: Hua-Wu
authors.initials: HW
authors.lastname: Zeng
authors.forename: Ji
authors.initials: J
authors.lastname: Ye
authors.forename: Hui-Liang
authors.initials: HL
authors.lastname: Li
authors.forename: Lei
authors.initials: L
authors.lastname: Shan
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Zhang
mesh_terms: D000818:Animals; D029402:Bignoniaceae / Q000737:chemistry*; D018360:Crystallography, X-Ray; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000276:immunology / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D019906:Nuclear Magnetic Resonance, Biomolecular; D013237:Stereoisomerism
chemical_list: D006576:Heterocyclic Compounds, 4 or More Rings; D008070:Lipopolysaccharides; C572693:incarvilleatone; D009569:Nitric Oxide