title: Anticholinesterase activity of endemic plant extracts from Soqotra.
abstract: A total of 30 chloroform and methanol extracts from the following endemic Soqotran plants Acridocarpus socotranus Olive, Boswellia socotranao Balf.fil, Boswellia elongata Balf. fil., Caralluma socotrana N. Br, Cephalocroton socotranus Balf.f, Croton socotranus Balf. fil.., Dendrosicycos socotrana Balf.f., Dorstenia gigas Schweinf. ex Balf. fil., Eureiandra balfourii Cogn. & Balf. fil., Kalanchoe farinaceae Balf.f, Limonium sokotranum (Vierh) Radcl. Sm), Oldenlandia pulvinata, Pulicaria diversifolia (Balf. and Pulicaria stephanocarpa Balf. were screened for their acetylcholinesterase inhibitory activity by using in vitro Ellman method at 50 and 200 µg/ml concentrations. Chloroform extracts of Croton socotranus, Boswellia socotrana, Dorstenia gigas, and Pulicaria stephanocarpa as well as methanol extracts of Eureiandra balfourii exhibited inhibitory activities higher than 50 % at concentration of 200 µg. At a concentrations of 50 µg, the chloroform extract of Croton socotranus exhibited an inhibition of 40.6 %.
authors.affiliation: Department of Pharmacology and Pharmaceutics, University of Aden, Aden, Yemen.
authors.forename: Hussein
authors.initials: H
authors.lastname: Bakthira
authors.forename: Nasser A
authors.initials: NA
authors.lastname: Awadh Ali
authors.forename: Norbert
authors.initials: N
authors.lastname: Arnold
authors.forename: Axel
authors.initials: A
authors.lastname: Teichert
authors.forename: Ludger
authors.initials: L
authors.lastname: Wessjohann
mesh_terms: D002725:Chloroform; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D020834:Ethnopharmacology; D007195:Indian Ocean Islands; D000432:Methanol; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: D002800:Cholinesterase Inhibitors; D010936:Plant Extracts; D002725:Chloroform; D000432:Methanol