title: The role of FK506-binding proteins 12 and 12.6 in regulating cardiac function.
abstract: Specifically, FK506-binding proteins 12 (FKBP12) and 12.6 (FKBP12.6) are cis-trans peptidyl prolyl isomerases that are expressed in the heart. Both FKBP12 and FKBP12.6 were previously known to interact with ryanodine receptors in striated muscles. Although FKBP12 is abundantly present in the heart, its function in the heart is largely uncertain. Recently, by generating FKBP12 transgenic overexpression and cardiac-restricted knockout mice, we showed that FKBP12 is critically important in regulating trans-sarcolemmal ionic currents, predominately the voltage-gated Na+ current, I(Na), but it appears to be less important for regulating cardiac ryanodine receptor function. Similar genetic approaches also confirm the role of FKBP12.6 in regulating cardiac ryanodine receptors. The current study demonstrated that FKBP12 and FKBP12.6 have very different physiologic functions in the heart.
authors.affiliation: Department of Pharmacology, Harbin Medical University, 157 Bao Jian Rd, Harbin, 150081, People's Republic of China.
authors.forename: Bai-Yan
authors.initials: BY
authors.lastname: Li
authors.forename: Hanying
authors.initials: H
authors.lastname: Chen
authors.forename: Mitsunori
authors.initials: M
authors.lastname: Maruyama
authors.forename: Wenjun
authors.initials: W
authors.lastname: Zhang
authors.forename: Jin
authors.initials: J
authors.lastname: Zhang
authors.forename: Zhen-Wei
authors.initials: ZW
authors.lastname: Pan
authors.forename: Michael
authors.initials: M
authors.lastname: Rubart
authors.forename: Peng-Sheng
authors.initials: PS
authors.lastname: Chen
authors.forename: Weinian
authors.initials: W
authors.lastname: Shou
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D006321:Heart / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D032383:Myocytes, Cardiac / Q000378:metabolism*; D019837:Ryanodine Receptor Calcium Release Channel / Q000378:metabolism*; D022021:Tacrolimus Binding Proteins / Q000378:metabolism*
chemical_list: D019837:Ryanodine Receptor Calcium Release Channel; D022021:Tacrolimus Binding Proteins; D002118:Calcium