title: Synthesis of chlorin-based unsaturated fatty acid conjugates: their in vitro phototoxicity on TC-1 cancer cell line.
abstract: Chlorin-based photosensitizers in photodynamic therapy are the promising anticancer agents, but some of their properties such as specific-targeting to tumor need to be improved. The aim of this study was to synthesize chlorin-based unsaturated fatty acid conjugates to obtain an optimal photosensitizers. Thus four chlorin-based fatty acid conjugates were successfully synthesized through an esterification reaction using carbodiimide coupling reagents in enough yields. Then, structures of these conjugates were confirmed by (1)H NMR, MALDI-MS, and UV-vis spectroscopy. Furthermore, their in vitro phototoxicity and cellular uptake were evaluated on TC-1 lung cancer cell line and HeLa cell line.
authors.affiliation: Cancer Research Institute, Catholic Research Institute of Medical Science, The Catholic University of Korea, Republic of Korea.
authors.forename: Gantumur
authors.initials: G
authors.lastname: Battogtokh
authors.forename: Hai-Bo
authors.initials: HB
authors.lastname: Liu
authors.forename: Su-Mi
authors.initials: SM
authors.lastname: Bae
authors.forename: Pankaj Kumar
authors.initials: PK
authors.lastname: Chaturvedi
authors.forename: Yong-Wan
authors.initials: YW
authors.lastname: Kim
authors.forename: In-Wook
authors.initials: IW
authors.lastname: Kim
authors.forename: Woong Shick
authors.initials: WS
authors.lastname: Ahn
mesh_terms: D045744:Cell Line, Tumor; D005231:Fatty Acids, Unsaturated / Q000737:chemistry* / Q000627:therapeutic use; D006367:HeLa Cells; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy; D019906:Nuclear Magnetic Resonance, Biomolecular; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D011166:Porphyrins / Q000138:chemical synthesis* / Q000627:therapeutic use
chemical_list: D005231:Fatty Acids, Unsaturated; D017319:Photosensitizing Agents; D011166:Porphyrins; C006969:chlorin