title: Audiological monitoring for ototoxic tuberculosis, human immunodeficiency virus and cancer therapies in a developing world setting.
abstract: Ototoxic drugs are widely used in the developing world, without audiological monitoring. Epidemiological data on ototoxic deafness are lacking for developing countries. The public health aspect of ototoxicity is often overlooked, to the detriment of the individual patient. This paper reviews ototoxic hearing loss, particularly in sub-Saharan Africa, and also assesses the impact of treatments for tuberculosis, cancer and human immunodeficiency virus (the latter including highly active antiretroviral therapy) on ototoxic hearing loss. The paper also discusses obstacles to audiological monitoring for ototoxicity in the developing world, and the potential of audiology screening using applications for mobile devices.
authors.affiliation: Department of Otolaryngology, Kimberley Hospital Complex, University of Cape Town, South Africa. harristasneem@yahoo.com
authors.forename: T
authors.initials: T
authors.lastname: Harris
authors.forename: S
authors.initials: S
authors.lastname: Peer
authors.forename: J J
authors.initials: JJ
authors.lastname: Fagan
mesh_terms: D017954:Africa South of the Sahara / Q000453:epidemiology; D000617:Aminoglycosides / Q000009:adverse effects*; D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects*; D000995:Antitubercular Agents / Q000009:adverse effects*; D001298:Audiology / Q000458:organization & administration* / Q000592:standards; D001301:Audiometry, Pure-Tone / Q000379:methods; D040421:Cell Phone; D003906:Developing Countries; D004357:Drug Synergism; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology; D034381:Hearing Loss / Q000139:chemically induced* / Q000453:epidemiology / Q000517:prevention & control; D006801:Humans; D008403:Mass Screening / Q000458:organization & administration*; D008507:Medically Underserved Area; D009369:Neoplasms / Q000188:drug therapy / Q000453:epidemiology; D014376:Tuberculosis / Q000188:drug therapy / Q000453:epidemiology
chemical_list: D000617:Aminoglycosides; D000970:Antineoplastic Agents; D000995:Antitubercular Agents