title: Essential oil from the leaves of Annona vepretorum: chemical composition and bioactivity.
abstract: The essential oil from the leaves of Annona vepretorun was obtained by hydrodistillation using a Clevenger-type apparatus and analyzed by GC-MS and GC-FID. Eighteen compounds representing 98.1% of the crude essential oil were identified. The major compounds identified were bicyclogermacrene (43.7%), spathulenol (11.4%), alpha-felandrene (10.0%), alpha-pinene (7.1%), (E)-beta-ocimene (6.8%), germacrene D (5.8%), and p-cymene (4.2%). The trypanocidal activity against Trypanosoma cruzi epimastigote forms, as well as, the antimicrobial and antioxidant proprieties was investigated. The essential oil showed a potent trypanocidal activity with IC50 value of 31.9 +/-1.3 microg x mL(-1). For antimicrobial activity, the best result was observed against Candida tropicalis with a MIC value of 100 microg x mL(-1). For antioxidant capacity the essential oil showed weak activity.
authors.affiliation: Department of Chemistry, Federal University of Sergipe, São Cristóvão, Sergipe, Brazil 49100-000. emmanoelvilaca@yahoo.com.br
authors.forename: Emmanoel Vilaça
authors.initials: EV
authors.lastname: Costa
authors.forename: Lívia Macedo
authors.initials: LM
authors.lastname: Dutra
authors.forename: Paulo Cesar de Lima
authors.initials: PC
authors.lastname: Nogueira
authors.forename: Valéria Regina de Souza
authors.initials: VR
authors.lastname: Moraes
authors.forename: Marcos José
authors.initials: MJ
authors.lastname: Salvador
authors.forename: Luis Henrique Gonzaga
authors.initials: LH
authors.lastname: Ribeiro
authors.forename: Fernanda Ramos
authors.initials: FR
authors.lastname: Gadelha
mesh_terms: D031041:Annona / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology*; D009822:Oils, Volatile / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry*; D010938:Plant Oils / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D009822:Oils, Volatile; D010938:Plant Oils