title: Focused attention, heart rate deceleration, and cognitive development in preterm and full-term infants.
abstract: The majority of children who are born very preterm escape major impairment, yet more subtle cognitive and attention problems are very common in this population. Previous research has linked infant focused attention during exploratory play to later cognition in children born full-term and preterm. Infant focused attention can be indexed by sustained decreases in heart rate (HR). However there are no preterm studies that have jointly examined infant behavioral attention and concurrent HR response during exploratory play in relation to developing cognition. We recruited preterm infants free from neonatal conditions associated with major adverse outcomes, and further excluded infants with developmental delay (Bayley Mental Development Index [MDI < 70]) at 8 months corrected age (CA). During infant exploratory play at 8 months CA, focused attention and concurrent HR response were compared in 83 preterm infants (born 23-32 weeks gestational age [GA]) who escaped major impairment to 46 full-term infants. Focused attention and HR response were then examined in relation to Bayley MDI, after adjusting for neonatal risk. MDI did not differ by group, yet full-term infants displayed higher global focused attention ratings. Among the extremely preterm infants born <29 weeks, fewer days on mechanical ventilation, mean longest focus, and greater HR deceleration during focused attention episodes, accounted for 49% of adjusted variance in predicting concurrent MDI. There were no significant associations for later-born gestational age (29-32 weeks) or full-term infants. Among extremely preterm infants who escape major impairment, our findings suggest unique relationships between focused attention, HR deceleration, and developing cognition.
authors.affiliation: Neonatal Follow-Up Program, Children's and Women's Health Centre of British Columbia, Vancouver, BC, Canada. jpetrie@cw.bc.ca
authors.forename: Julianne H
authors.initials: JH
authors.lastname: Petrie Thomas
authors.forename: Michael F
authors.initials: MF
authors.lastname: Whitfield
authors.forename: Tim F
authors.initials: TF
authors.lastname: Oberlander
authors.forename: Anne R
authors.initials: AR
authors.lastname: Synnes
authors.forename: Ruth E
authors.initials: RE
authors.lastname: Grunau
mesh_terms: D001288:Attention / Q000502:physiology*; D002657:Child Development / Q000502:physiology*; D003071:Cognition / Q000502:physiology*; D005106:Exploratory Behavior / Q000502:physiology; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D010988:Play and Playthings