title: The enduring enigma of nuclear translation.
abstract: Although the physical separation of transcription in the nucleus and translation in the cytoplasm has presided as a fundamental tenet of cell biology for decades, it has not done so without recurring challenges and contentious debate. In this issue, David et al. (2012. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201112145) rekindle the controversy by providing convincing experimental evidence for nuclear translation.
authors.affiliation: Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: David W
authors.initials: DW
authors.lastname: Reid
authors.forename: Christopher V
authors.initials: CV
authors.lastname: Nicchitta
mesh_terms: D002467:Cell Nucleus / Q000378:metabolism*; D006801:Humans; D014176:Protein Biosynthesis; D011691:Puromycin / Q000378:metabolism*; D012270:Ribosomes / Q000378:metabolism*
chemical_list: D011691:Puromycin