title: Genetic variability of enterobacterial resistant integrons.
abstract: Sulfamide-resistant (SulR) natural strains of enterobacteria (11.9% of a total of 797 cultures, isolated with enteric microflora of honeybee gut, bee-fermented pollen, and plant issues) were tested for class 1 antibiotic resistance integrons (MRI). Only 5.3% of SulR strains were MRI-positive. Mutability of weak (wild type) MRI promotor has been shown. A more active hybrid promotor type has been amplified in isolated Klebsiella oxytoca strains. Regulatory genetic modifications in MRI are fraught with the development of multiple drug resistance of opportunistic strains.
authors.affiliation: Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences, Perm, Russia. solomen@iegm.ru
authors.forename: A P
authors.initials: AP
authors.lastname: Solomenny
authors.forename: Ya E
authors.initials: YE
authors.lastname: Lyapunov
authors.forename: R Z
authors.initials: RZ
authors.lastname: Kuzyaev
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001483:Base Sequence; D001516:Bees / Q000382:microbiology; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D004755:Enterobacteriaceae / Q000235:genetics* / Q000302:isolation & purification; D005798:Genes, Bacterial; D014644:Genetic Variation; D032023:Integrons / Q000235:genetics*; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D017422:Sequence Analysis, DNA; D013409:Sulfacetamide / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D013409:Sulfacetamide