title: Actinic cheilitis and squamous cell carcinoma of the lip: clinical, histopathological and immunogenetic aspects.
abstract: Actinic cheilitis is the main precancerous lesion of the lip. Squamous cell carcinoma of the lip is reported together with oral carcinomas in the Brazilian official statistics. Overall, they account for 40% of the head and neck carcinomas. In general, physicians and dentists know little about what causes oral tumor development and progression. Tumor suppressor genes and cell proliferation regulatory proteins play a role in the progression of actinic cheilitis to squamous cell carcinoma and in its biological behavior. Knowledge on prognostic and diagnostic markers has a positive impact on the follow-up of these patients.
authors.affiliation: Outpatient Clinic of Stomatology, Department of Dermatology and Radiotherapy, Medical School of Botucatu, Universidade Estadual Paulista Júlio de Mesquita Filho, Sao Paulo, SP, Brazil.
authors.forename: Renata Aparecida Martinez Antunes Ribeiro
authors.initials: RA
authors.lastname: Vieira
authors.forename: Eliana Maria
authors.initials: EM
authors.lastname: Minicucci
authors.forename: Mariangela Esther Alencar
authors.initials: ME
authors.lastname: Marques
authors.forename: Silvio Alencar
authors.initials: SA
authors.lastname: Marques
mesh_terms: D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000628:therapy; D002613:Cheilitis / Q000473:pathology* / Q000628:therapy; D018450:Disease Progression; D006801:Humans; D008048:Lip Neoplasms / Q000473:pathology* / Q000628:therapy; D013472:Sunlight / Q000009:adverse effects