title: Neuroprotective effect of GK-2, a dipeptide mimetic of nerve growth factor, during experimental focal ischemia in middle cerebral artery basin.
abstract: Magnetic resonance tomography, staining with triphenyltetrazolium chloride, and tests for evaluation of functional disturbances "cylinder" and "limb stimulation" showed that daily intraperitoneal injection of dipeptide mimetic of nerve growth factor GK-2 (1 mg/kg) for 6 days to rats with experimental focal ischemia provoked by unilateral intravascular occlusion of a branch of the middle cerebral artery significantly improved neurological deficit and decreased the infarction area.
authors.affiliation: V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: S B
authors.initials: SB
authors.lastname: Seredenin
authors.forename: D N
authors.initials: DN
authors.lastname: Silachev
authors.forename: T A
authors.initials: TA
authors.lastname: Gudasheva
authors.forename: Yu A
authors.initials: YA
authors.lastname: Pirogov
authors.forename: N K
authors.initials: NK
authors.lastname: Isaev
mesh_terms: D020816:Amino Acid Motifs; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000473:pathology; D002545:Brain Ischemia / Q000188:drug therapy*; D004151:Dipeptides / Q000494:pharmacology* / Q000627:therapeutic use; D004195:Disease Models, Animal; D020244:Infarction, Middle Cerebral Artery / Q000188:drug therapy*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D020932:Nerve Growth Factor / Q000737:chemistry; D018696:Neuroprotective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats
chemical_list: D004151:Dipeptides; D018696:Neuroprotective Agents; C572946:bis(N-succinyl-glutamyllysin)hexamethylenediamine; D020932:Nerve Growth Factor