title: Changes in serum lipids and blood glucose in non diabetic patients with metabolic syndrome after mixed meals of different composition.
abstract: Aims. To investigate the postprandial changes in serum lipoproteins and blood glucose and to verify whether different nutrient composition of the meal elicits different response in patients with (MetS+) and without (MetS-) metabolic syndrome. Research Design and Methods. 50 MetS+ patients and 50 age- and sex-matched MetS- consumed a regular lunch chosen among those more similar to their usual diet. Blood was drawn in the morning after 12-hour fasting and 2 and 4:30 hours after the meal. Results. Serum triglycerides increased more in MetS+ (35%, 4:30 hours after the meal) than in MetS- (29%), HDL-cholesterol decreased 2 hours after the meal in both groups (-4% and -5%, resp.). Blood sugar similarly increased in both groups (19%, 2 hours after the meal in MetS+ and 17% in MetS-) and plasma insulin increased more and remained high longer in MetS+ (73.5 and 52.3 μU/mL, 2 and 4:30 hours after the meal) than in MetS- (46.7 and 21.6 μU/mL). Difference in nutrient composition of the meal (carbohydrate 57%, fat 28% versus carbohydrate 45%, fat 35%) was not associated with differences in postprandial levels of triglycerides, HDL-cholesterol, glucose, and insulin within each group. Conclusions. As compared with MetS-, MetS+ patients show a greater hypertriglyceridemic and hyperinsulinemic response to a regular lunch whatever the carbohydrate or fat content of the meal.
authors.affiliation: Centro per lo Studio e la Prevenzione dell'Aterosclerosi, Department of Internal Medicine, Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico, University of Milan, via F. Sforza 35, 20122 Milan, Italy.
authors.forename: Adriana
authors.initials: A
authors.lastname: Branchi
authors.forename: Adriana
authors.initials: A
authors.lastname: Torri
authors.forename: Cristina
authors.initials: C
authors.lastname: Berra
authors.forename: Emanuela
authors.initials: E
authors.lastname: Colombo
authors.forename: Domenico
authors.initials: D
authors.lastname: Sommariva