title: Increasing materials' response to two-photon NIR light via self-immolative dendritic scaffolds.
abstract: Photoactivation using two photons of NIR allows non-invasive biological manipulation. We applied the principle of dendritic amplification to improve the materials' sensitivity to NIR light. Light induced uncaging or release of L-glutamic acid was 2.8 fold higher when incorporating 4-bromo-7-hydroxycoumarin (Bhc) with self-immolative dendrimers compared with Bhc directly conjugated to L-glutamic acid.
authors.affiliation: Skaggs School Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, California 92093, USA.
authors.forename: Nadezda
authors.initials: N
authors.lastname: Fomina
authors.forename: Cathryn L
authors.initials: CL
authors.lastname: McFearin
authors.forename: Adah
authors.initials: A
authors.lastname: Almutairi
mesh_terms: D003374:Coumarins / Q000138:chemical synthesis / Q000737:chemistry*; D050091:Dendrimers / Q000138:chemical synthesis / Q000737:chemistry*; D004337:Drug Carriers / Q000138:chemical synthesis / Q000737:chemistry*; D018698:Glutamic Acid / Q000008:administration & dosage* / Q000737:chemistry; D008027:Light; D055668:Photochemical Processes; D017785:Photons
chemical_list: D003374:Coumarins; D050091:Dendrimers; D004337:Drug Carriers; D018698:Glutamic Acid