title: The association of hypertriglyceridemia with cardiovascular events and pancreatitis: a systematic review and meta-analysis.
abstract: BACKGROUND
  Hypertriglyceridemia may be associated with important complications. The aim of this study is to estimate the magnitude of association and quality of supporting evidence linking hypertriglyceridemia to cardiovascular events and pancreatitis.
  
  
  METHODS
  We conducted a systematic review of multiple electronic bibliographic databases and subsequent meta-analysis using a random effects model. Studies eligible for this review followed patients longitudinally and evaluated quantitatively the association of fasting hypertriglyceridemia with the outcomes of interest. Reviewers working independently and in duplicate reviewed studies and extracted data.
  
  
  RESULTS
  35 studies provided data sufficient for meta-analysis. The quality of these observational studies was moderate to low with fair level of multivariable adjustments and adequate exposure and outcome ascertainment. Fasting hypertriglyceridemia was significantly associated with cardiovascular death (odds ratios (OR) 1.80; 95% confidence interval (CI) 1.31-2.49), cardiovascular events (OR, 1.37; 95% CI, 1.23-1.53), myocardial infarction (OR, 1.31; 95% CI, 1.15-1.49), and pancreatitis (OR, 3.96; 95% CI, 1.27-12.34, in one study only). The association with all-cause mortality was not statistically significant.
  
  
  CONCLUSIONS
  The current evidence suggests that fasting hypertriglyceridemia is associated with increased risk of cardiovascular death, MI, cardiovascular events, and possibly acute pancreatitis.Précis: hypertriglyceridemia is associated with increased risk of cardiovascular death, MI, cardiovascular events, and possibly acute pancreatitis.
authors.affiliation: Knowledge and Evaluation Research Unit, Mayo Clinic, Rochester, MN, USA. Murad.mohammad@mayo.edu.
authors.forename: M Hassan
authors.initials: MH
authors.lastname: Murad
authors.forename: Ahmad
authors.initials: A
authors.lastname: Hazem
authors.forename: Fernando
authors.initials: F
authors.lastname: Coto-Yglesias
authors.forename: Svitlana
authors.initials: S
authors.lastname: Dzyubak
authors.forename: Shabnum
authors.initials: S
authors.lastname: Gupta
authors.forename: Irina
authors.initials: I
authors.lastname: Bancos
authors.forename: Melanie A
authors.initials: MA
authors.lastname: Lane
authors.forename: Patricia J
authors.initials: PJ
authors.lastname: Erwin
authors.forename: Lars
authors.initials: L
authors.lastname: Berglund
authors.forename: Tarig
authors.initials: T
authors.lastname: Elraiyah
authors.forename: Victor M
authors.initials: VM
authors.lastname: Montori