title: Acentrosomal spindle assembly and chromosome segregation during oocyte meiosis.
abstract: The ability to reproduce relies in most eukaryotes on specialized cells called gametes. Gametes are formed by the process of meiosis in which, after a single round of replication, two successive cell divisions reduce the ploidy of the genome. Fusion of gametes at fertilization reconstitutes diploidy. In most animal species, chromosome segregation during female meiosis occurs on spindles assembled in the absence of the major microtubule-organizing center, the centrosome. In mammals, oocyte meiosis is error prone and underlies most birth aneuploidies. Here, we review recent work on acentrosomal spindle formation and chromosome alignment/separation during oocyte meiosis in different animal models.
authors.affiliation: Institut Jacques Monod, CNRS, UMR 7592, Université Paris Diderot, Sorbonne Paris Cité, F-75205 Paris, France. dumont@ijm.univ-paris-diderot.fr
authors.forename: Julien
authors.initials: J
authors.lastname: Dumont
authors.forename: Arshad
authors.initials: A
authors.lastname: Desai
mesh_terms: D000818:Animals; D018385:Centrosome; D020090:Chromosome Segregation; D006801:Humans; D008540:Meiosis; D008870:Microtubules; D009865:Oocytes / Q000166:cytology*