title: [Inhibitory activity of hydrosols prepared from 18 Japanese herbs of weak aromatic flavor against filamentous formation and growth of Candida albicans].
abstract: Leaf hydrosols prepared from 18 weakly aromatic Japanese herbs used traditionally were tested on the filamentation-inhibitory activity of Candida albicans. These hydrosols were divided into two classes, A and B. The inhibitory activity of 13 hydrosols belonging to class A was markedly altered depending on the drying process of the parent herbs. On the other hand, the remaining 5 hydrosols belonging to class B showed no significant change on the composition and inhibitory activity upon drying. The change of the bioactivity was correlated with the change and concentration of the respective major constituents. Especially strong bioactivity shown by hydrosols of dried Houttuynia cordata and fresh Prunus pendula was ascribed to n-capric acid and cyanide, respectively. Eight hydrosols exhibited weak or moderate activity against the growth of C. albicans.
authors.affiliation: Teikyo University Institute of Medical Mycology.
authors.forename: Shigeharu
authors.initials: S
authors.lastname: Inouye
authors.forename: Miki
authors.initials: M
authors.lastname: Takahashi
authors.forename: Shigeru
authors.initials: S
authors.lastname: Abe
mesh_terms: D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development; D002208:Caproates / Q000302:isolation & purification / Q000494:pharmacology*; D003486:Cyanides / Q000302:isolation & purification / Q000494:pharmacology*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D025141:Drug Resistance, Fungal; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves; D010946:Plants, Medicinal / Q000737:chemistry; D014867:Water
chemical_list: D002208:Caproates; D003486:Cyanides; D010936:Plant Extracts; D014867:Water; C037652:hexanoic acid