title: Evaluation of serum levels of interleukin-6 and interleukin-10 in patients undergoing laparoscopic versus conventional cholecystectomy.
abstract: OBJECTIVE
  To correlate serum preoperative and postoperative interleukin-6 and interleukin-10 levels in patients undergoing laparotomy versus laparoscopic cholecystectomy.
  
  
  METHODS
  From a total of 20 patients, 18 were included in the study, nine underwent cholecystectomy by laparoscopy and the other nine by laparotomy. Serum concentrations of IL-6 and IL-10 were measured in both groups. Blood samples were obtained in the times of 24 hours preoperatively and four, 12 and 24 hours after the procedure. The groups were compared regarding age, gender, body mass index (BMI), duration of anesthesia and operation.
  
  
  RESULTS
  There was no significant statistical differences between groups related to age, gender, BMI, duration of anesthesia and operation. The comparison between the two procedurs demonstrated statistical differences for IL-6 in time 12 hours after operation (218.64 pg/ml laparotomic versus 67.71 pg/ml laparoscopic, p = 0.0003) and for IL-10 in time 24 hours after the procedure (24.46 pg/ml open versus 10.17 pg/qml laparoscopic, p <0.001).
  
  
  CONCLUSIONS
  There was an Increase in plasma levels of interleukin-6 and 10 after surgical trauma with a significant increase in levels of interleukins in the laparotomic group in comparison with the laparoscopic group.
authors.affiliation: Catholic University of Paraná, Brazil.
authors.forename: Fábio Porto
authors.initials: FP
authors.lastname: Silveira
authors.forename: João Eduardo
authors.initials: JE
authors.lastname: Nicoluzzi
authors.forename: Nestor Saucedo
authors.initials: NS
authors.lastname: Saucedo Júnior
authors.forename: Fábio
authors.initials: F
authors.lastname: Silveira
authors.forename: Guilherme Matiolli
authors.initials: GM
authors.lastname: Nicollelli
authors.forename: Bruno Souza De Albuquerque
authors.initials: BS
authors.lastname: Maranhão
mesh_terms: D000328:Adult; D002763:Cholecystectomy; D017081:Cholecystectomy, Laparoscopic; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D011300:Preoperative Care; D011446:Prospective Studies
chemical_list: D015850:Interleukin-6; D016753:Interleukin-10