title: Periodontitis and Alzheimer's disease: oral systemic link still on the rise?
abstract: Over the past few years, there has been a rapid rise in the older segments of the world population, which has brought along with it a major health concern: dementia. Alzheimer's disease, considered to be the most common cause of dementia, has become a prospect feared by the elderly. Inflammation of the brain is strongly implicated in Alzheimer's disease which could be enhanced by systemic inflammation. Periodontitis being a chronic inflammatory condition, which can cause systemic inflammation, the question is whether chronic periodontitis can initiate or hasten the rate of progression of Alzheimer's disease in susceptible individuals. In this article, the authors outline the proposed oral systemic link between periodontitis and Alzheimer's disease.
authors.affiliation: Department of Periodontics, Manipal College of Dental Sciences, Manipal University, Mangalore, Karnataka, India.
authors.forename: Ashita S
authors.initials: AS
authors.lastname: Uppoor
authors.forename: Hima S
authors.initials: HS
authors.lastname: Lohi
authors.forename: Dilip
authors.initials: D
authors.lastname: Nayak
mesh_terms: D000375:Aging / Q000502:physiology; D000544:Alzheimer Disease / Q000150:complications* / Q000235:genetics; D001921:Brain / Q000276:immunology / Q000382:microbiology; D055113:Chronic Periodontitis / Q000150:complications* / Q000235:genetics; D006304:Health Status; D054884:Host-Pathogen Interactions; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D018836:Inflammation Mediators / Q000276:immunology; D002537:Intracranial Arteriosclerosis / Q000150:complications; D009909:Oral Health
chemical_list: D018836:Inflammation Mediators