title: Anti-obesity properties of a Sasa quelpaertensis extract in high-fat diet-induced obese mice.
abstract: This study explores the anti-obesity properties of a Sasa quelpaertensis leaf extract (SQE) in high-fat diet (HFD)-induced obese C57BL/6 mice and mature 3T3-L1 adipocytes. SQE administration with HFD for 70 d significantly decreased the body weight gain, adipose tissue weight, and serum total cholesterol and triglyceride levels in comparison with the HFD group. SQE administration also reduced the serum levels of glutamic oxaloacetic transaminase, glutamic pyruvic transaminase and lactate dehydrogenase, and the accumulation of lipid droplets in the liver, suggesting a protective effect against HFD-induced hepatic steatosis. SQE administration restored the HFD-induced decreases with phosphorylation of AMP-activated protein kinase (AMPK) and acetyl-CoA carboxylase (ACC) in epididymal adipose tissue. SQE also induced AMPK phosphorylation in mature 3T3-L1 adipocytes. These results suggest that SQE exerted an anti-obesity effect on HFD-induced obese mice by activating AMPK in adipose tissue and reducing lipid droplet accumulation in the liver.
authors.affiliation: Department of Biology, Jeju National University, Jejusi, Jeju, Republic of Korea.
authors.forename: Seong-Il
authors.initials: SI
authors.lastname: Kang
authors.forename: Hye-Sun
authors.initials: HS
authors.lastname: Shin
authors.forename: Hyo-Min
authors.initials: HM
authors.lastname: Kim
authors.forename: Youn-Suk
authors.initials: YS
authors.lastname: Hong
authors.forename: Seon-A
authors.initials: SA
authors.lastname: Yoon
authors.forename: Seung-Woo
authors.initials: SW
authors.lastname: Kang
authors.forename: Jeong-Hwan
authors.initials: JH
authors.lastname: Kim
authors.forename: Hee-Chul
authors.initials: HC
authors.lastname: Ko
authors.forename: Se-Jae
authors.initials: SJ
authors.lastname: Kim
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000378:metabolism; D017667:Adipocytes / Q000187:drug effects* / Q000473:pathology; D000273:Adipose Tissue / Q000187:drug effects / Q000473:pathology; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D019440:Anti-Obesity Agents / Q000302:isolation & purification / Q000494:pharmacology; D001219:Aspartate Aminotransferases / Q000097:blood; D002460:Cell Line; D059305:Diet, High-Fat / Q000009:adverse effects; D005234:Fatty Liver / Q000188:drug therapy* / Q000201:enzymology / Q000209:etiology / Q000503:physiopathology; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D051379:Mice; D008820:Mice, Obese; D009765:Obesity / Q000188:drug therapy* / Q000201:enzymology / Q000209:etiology / Q000503:physiopathology; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage* / Q000302:isolation & purification / Q000627:therapeutic use; D018515:Plant Leaves / Q000737:chemistry; D031787:Sasa / Q000737:chemistry*; D015430:Weight Gain / Q000187:drug effects
chemical_list: D019440:Anti-Obesity Agents; D010936:Plant Extracts; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D055372:AMP-Activated Protein Kinases