title: Multiscale model of fibrin accumulation on the blood clot surface and platelet dynamics.
abstract: A multiscale computational model of thrombus (blood clot) development is extended by incorporating a submodel describing formation of fibrin network through "fibrin elements" representing regions occupied by polymerized fibrin. Simulations demonstrate that fibrin accumulates on the surface of the thrombus and that fibrin network limits growth by reducing thrombin concentrations on the thrombus surface and decreasing adhesivity of resting platelets in blood near thrombus surface. These results suggest that fibrin accumulation may not only increase the structural integrity of the thrombus but also considerably contribute toward limiting its growth. Also, a fast Graphics Processing Unit implementation is described for a multiscale computational model of the platelet-blood flow interaction.
authors.affiliation: Department of Applied and Computational Mathematics, University of Notre Dame, Notre Dame, Indiana, USA.
authors.forename: Zhiliang
authors.initials: Z
authors.lastname: Xu
authors.forename: Scott
authors.initials: S
authors.lastname: Christley
authors.forename: Joshua
authors.initials: J
authors.lastname: Lioi
authors.forename: Oleg
authors.initials: O
authors.lastname: Kim
authors.forename: Cameron
authors.initials: C
authors.lastname: Harvey
authors.forename: Wenzhao
authors.initials: W
authors.lastname: Sun
authors.forename: Elliot D
authors.initials: ED
authors.lastname: Rosen
authors.forename: Mark
authors.initials: M
authors.lastname: Alber
mesh_terms: D000818:Animals; D001777:Blood Coagulation / Q000502:physiology*; D001779:Blood Coagulation Factors / Q000378:metabolism; D001792:Blood Platelets / Q000166:cytology* / Q000378:metabolism; D003198:Computer Simulation; D005337:Fibrin / Q000378:metabolism; D005456:Fluorescent Dyes; D018056:Hemorheology; D008432:Mathematical Computing; D051379:Mice; D036641:Microscopy, Fluorescence, Multiphoton; D008954:Models, Biological; D008958:Models, Molecular; D010973:Platelet Adhesiveness; D013499:Surface Properties; D013917:Thrombin / Q000378:metabolism
chemical_list: D001779:Blood Coagulation Factors; D005456:Fluorescent Dyes; D005337:Fibrin; D013917:Thrombin