title: Variation in the HIF1A gene in elite rowers.
abstract: The transcription factor hypoxia-inducible factor 1 (HIF1) is one of the key regulators of cellular metabolism. The aim of this study was to analyze the possible importance of the HIF1A Pro582Ser polymorphisms in rowing. One hundred twenty-seven male Polish rowers (both former and current competitors) were recruited for this study. Genotyping was carried out by polymerase chain reaction. Significance was assessed by Chi-square (χ(2)) analysis. The results obtained revealed that frequency of the HIF1A Pro/Ser genotype (32.28 vs. 18.91%; p = 0.006) and Ser allele (16.93 vs. 10.00%; p = 0.01) were significantly higher in the rowers compared with those in controls. The results obtained confirm the significance of the HIF1A gene as a useful genetic marker in rowing. This kind of information would presumably be applicable in a program to search for the most predisposed individuals and also in the planning of training programs.
authors.affiliation: Department of Physical Culture and Health Promotion, University of Szczecin, Szczecin, Poland. cieszczyk@poczta.onet.pl
authors.forename: Pawel
authors.initials: P
authors.lastname: Cięszczyk
authors.forename: Michael
authors.initials: M
authors.lastname: Kalinski
authors.forename: Magdalena
authors.initials: M
authors.lastname: Ostanek
authors.forename: Nijole
authors.initials: N
authors.lastname: Jascaniene
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Krupecki
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Ficek
authors.forename: Marek
authors.initials: M
authors.lastname: Sawczuk
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Maciejewska
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D016009:Chi-Square Distribution; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010807:Physical Endurance / Q000235:genetics*; D011044:Poland; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D013177:Sports
chemical_list: D051795:Hypoxia-Inducible Factor 1, alpha Subunit