title: Melan-A/Mart-1- or HMB-45-positive melanocytes are not present in calcifying cystic odontogenic tumors (calcifying odontogenic cysts): a study in 13 Caucasian patients.
abstract: Melanin pigment and melanocytes may be found in odontogenic cysts and tumors, particularly calcifying cystic odontogenic tumor (CCOT). In the present study we investigated the immunohistochemical expression of the Melan-A/Mart-1 and HMB-45 antigens in 13 Caucasians patients with CCOT. Melan-A/Mart-1- and HMB-45-positive melanocytes were not seen in any of the cases. Our findings are in agreement with the assumption that pigmentation in odontogenic lesions may be a racial phenomenon.
authors.affiliation: Department of Oral Pathology, Dental School, University of Athens, Greece. ktosios@dent.uoa.gr
authors.forename: Konstantinos I
authors.initials: KI
authors.lastname: Tosios
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Prountzos
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Katsoulas
authors.forename: Ioannis G
authors.initials: IG
authors.lastname: Koutlas
authors.forename: Alexandra
authors.initials: A
authors.lastname: Sklavounou-Andrikopoulou
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D005260:Female; D006801:Humans; D007573:Jaw Neoplasms / Q000208:ethnology* / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D058965:MART-1 Antigen / Q000096:biosynthesis* / Q000235:genetics; D008297:Male; D008543:Melanins / Q000235:genetics; D008544:Melanocytes / Q000378:metabolism*; D058950:Melanoma-Specific Antigens / Q000096:biosynthesis* / Q000235:genetics; D008875:Middle Aged; D018333:Odontogenic Cyst, Calcifying / Q000208:ethnology* / Q000378:metabolism / Q000473:pathology*; D044465:White People / Q000235:genetics*; D055815:Young Adult; D058951:gp100 Melanoma Antigen
chemical_list: D058965:MART-1 Antigen; D008543:Melanins; D058950:Melanoma-Specific Antigens; C548637:PMEL protein, human; D058951:gp100 Melanoma Antigen