title: Association of polymorphisms in the estrogen receptor β (ESR2) with unexplained recurrent spontaneous abortion (URSA) in Chinese population.
abstract: OBJECTIVE
  To investigate the association of 1082G > A(RsaI) (rs1256049) and 1730A > G(AluI) (rs4986938) single nucleotide polymorphisms(SNPs), respectively - located on estrogen receptor β (ESR2) gene with recurrent spontaneous abortion (RSA) in Chinese population.
  
  
  METHODS
  The study group consisted of 196 patients with RSA and 182 fertile women as control. Two functional polymorphisms 1082G > A (a silent mutation in exon 5) and 1730A > G (3' nontranslated region of the exon 8) of ESR2 were studied by association analysis.
  
  
  RESULTS
  There were no significant differences between ESR2 gene polymorphisms and RSA (χ(2) =1.793, P=0.408; χ(2) =.432, P=0.489, respectively).
  
  
  CONCLUSIONS
  The present data indicate that the studied SNPs on ESR2 gene may not be associated with RSA in Chinese population.
authors.affiliation: Center of Reproductive Medicine, The First Affiliated Hospital of Anhui Medical University, AnHui, China.
authors.forename: Jingjing
authors.initials: J
authors.lastname: Hu
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Huifeng
authors.initials: H
authors.lastname: Xiang
authors.forename: Zelian
authors.initials: Z
authors.lastname: Li
authors.forename: Binbin
authors.initials: B
authors.lastname: Wang
authors.forename: Yunxia
authors.initials: Y
authors.lastname: Cao
authors.forename: Xu
authors.initials: X
authors.lastname: Ma
mesh_terms: D000026:Abortion, Habitual / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics*; D000328:Adult; D044466:Asian People / Q000235:genetics / Q000706:statistics & numerical data; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D047629:Estrogen Receptor beta / Q000235:genetics*; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000502:physiology; D011153:Population; D011247:Pregnancy; D055815:Young Adult
chemical_list: D047629:Estrogen Receptor beta