title: Novel roles of SUMO in pancreatic β-cells: thinking outside the nucleus.
abstract: The endocrine pancreas is critically important in the regulation of energy metabolism, with defective insulin secretion from pancreatic islet β-cells a major contributing factor to the development of type 2 diabetes. Small ubiquitin-like modifier (SUMO) proteins have been demonstrated to covalently modify a wide range of target proteins, mediating a broad range of cellular processes. While the effects of SUMOylation on β-cell gene transcription have been previously reviewed, recent reports indicate roles for SUMO outside of the nucleus. In this review we shall focus on the reported non-nuclear roles of SUMOylation in the regulation of β-cells, including SUMOylation as a novel signaling pathway in the acute regulation of insulin secretion.
authors.affiliation: Department of Pharmacology and Alberta Diabetes Institute, Li Ka Shing Centre, University of Alberta, Edmonton, AB T6G 2E1, Canada. jm33@ualberta.ca
authors.forename: Jocelyn E
authors.initials: JE
authors.lastname: Manning Fox
authors.forename: Catherine
authors.initials: C
authors.lastname: Hajmrle
authors.forename: Patrick E
authors.initials: PE
authors.lastname: Macdonald
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D007328:Insulin / Q000235:genetics / Q000378:metabolism; D050417:Insulin-Secreting Cells / Q000378:metabolism / Q000502:physiology*; D025842:SUMO-1 Protein / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction
chemical_list: D007328:Insulin; D025842:SUMO-1 Protein