title: Genetic background and 227Thorium as risk factors in biologically based models for induction of bone cancer in mice.
abstract: We explore the potential for the biologically based two-stage clonal expansion model to make statements about the influence of genetic factors on the steps in the model. We find evidence that the different susceptibility of BALB/C and CBA/Ca mice to bone cancer after (227)Thorium injection may be mostly due to different promotional responses to radiation. In BALB/C × CBA/Ca back-crossed mice, we analyzed the specific contribution of two individual loci in the carcinogenic process. This analysis suggests that the two high- or low-risk alleles are acting on promotion or on the background parameters, but not on radiation-induced initiation. Taken together with the comparison of CBA/Ca and BALB/C mice, this hints at the possibility that the two loci are candidates for modifying radiation-induced promotion.
authors.affiliation: Institute for Radiation Protection, Helmholtz Zentrum München, German Research Center for Environmental Health (GmbH), Neuherberg, Germany. heidenreich@helmholtz-muenchen.de
authors.forename: W F
authors.initials: WF
authors.lastname: Heidenreich
authors.forename: M
authors.initials: M
authors.lastname: Rosemann
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000209:etiology* / Q000235:genetics*; D003043:Cocarcinogenesis; D004195:Disease Models, Animal; D005260:Female; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007267:Injections; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D008957:Models, Genetic; D009381:Neoplasms, Radiation-Induced / Q000235:genetics*; D012307:Risk Factors; D013910:Thorium / Q000633:toxicity*
chemical_list: D013910:Thorium