title: Clinicopathological features of human brainstem gliomas.
abstract: We describe the clinicopathological features of 25 brainstem gliomas (BSGs). Twenty BSGs located in the pons and were all in children. Four BSGs located in the medulla oblongata were in 2 children and 2 adults. One (in a child) was located in the midbrain. Radiological findings on MR images were low-intensity on T1 weighted images and high-intensity on T2 weighted images. Mean survival when pontine glioma was treated by radiotherapy and/or use of temozolomide was 14 months, although 4 patients (3 cervicomedullary types and one focal type arising from midbrain) are alive. Follow up was from 5 months to 6 years. Histopathological features of 10 cases of the diffuse type were: 4 grade II astrocytomas, 4 grade III astrocytomas, and 2 glioblastomas. MIB-1 index was from 0.8 to 38 %. P53 was positive for 80 % of 15 tumors and there were no negative results. MGMT was positive in 60 % of 15 tumors and negative in 12.4 %. IDH1 was negative in 61.6 %. There was no positive result for IDH1 in this study. Thus, our histopathological results were indicative of high p53 immunoreactivity and no IDH1 immunoreactivity related to secondary malignant change.
authors.affiliation: Department of Neurosurgery, Kitasato University School of Medicine, 1-15-1 Kitasato, Minimi-ku, Sagamihara, Kanagawa 225-318, Japan. okahiro@med.kitasato-u.ac.jp
authors.forename: Hidehiro
authors.initials: H
authors.lastname: Oka
authors.forename: Satoshi
authors.initials: S
authors.lastname: Utsuki
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Tanizaki
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Hagiwara
authors.forename: Yoshiteru
authors.initials: Y
authors.lastname: Miyajima
authors.forename: Kimitoshi
authors.initials: K
authors.lastname: Sato
authors.forename: Mari
authors.initials: M
authors.lastname: Kusumi
authors.forename: Chihiro
authors.initials: C
authors.lastname: Kijima
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Fujii
mesh_terms: D000293:Adolescent; D000328:Adult; D020295:Brain Stem Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D005260:Female; D005910:Glioma / Q000378:metabolism / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D006801:Humans; D007223:Infant; D007521:Isocitrate Dehydrogenase / Q000378:metabolism; D008297:Male; D008526:Medulla Oblongata / Q000378:metabolism / Q000473:pathology*; D008636:Mesencephalon / Q000378:metabolism / Q000473:pathology*; D008875:Middle Aged; D015996:Survival Rate; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
chemical_list: D016159:Tumor Suppressor Protein p53; D007521:Isocitrate Dehydrogenase; C543588:IDH1 protein, human