title: Papillary tumor of the pineal region: a case involving isocitrate dehydrogenase (IDH) genotyping.
abstract: Papillary tumor of the pineal region (PTPR) is a recently described neoplasm. Several studies have been published on this tumor, but its pathological features and the appropriate treatment remain unclear. PTPR is reported to originate from ependymal cells in the subcommissural organ. Isocitrate dehydrogenase 1 and 2 (IDH1/2) mutations have been a focus area in glioma research as promising predictors. We report a case of PTPR that was characterized by local recurrence, although subtotal removal and radiotherapy seemed effective for many months. Histological examination showed ependymal features in the surgical specimens. As far as we are aware, this case study is the first to show that the IDH1/2 genotypes in PTPR cells are wild-type genotypes, which is consistent with the negative immunoreactivity that was observed for the IDH1 mutant antibody in this study.
authors.affiliation: Department of Neurosurgery, Moriyama Memorial Hospital, 7-12-7 Nishikasai, Edogawa-ku, Tokyo 134-8608, Japan. danyonatsushi@gmail.com
authors.forename: Atsushi
authors.initials: A
authors.lastname: Ishida
authors.forename: Makoto
authors.initials: M
authors.lastname: Shibuya
authors.forename: Takashi
authors.initials: T
authors.lastname: Komori
authors.forename: Sumihito
authors.initials: S
authors.lastname: Nobusawa
authors.forename: Kaku
authors.initials: K
authors.lastname: Niimura
authors.forename: Seigo
authors.initials: S
authors.lastname: Matsuo
authors.forename: Tomokatsu
authors.initials: T
authors.lastname: Hori
mesh_terms: D001932:Brain Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D002291:Carcinoma, Papillary / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D005838:Genotype; D006801:Humans; D007521:Isocitrate Dehydrogenase / Q000235:genetics*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000235:genetics / Q000473:pathology / Q000601:surgery; D010870:Pineal Gland / Q000473:pathology* / Q000601:surgery; D010871:Pinealoma / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D055815:Young Adult
chemical_list: D007521:Isocitrate Dehydrogenase