title: Efficacy of 20-OH-ecdysone on hepatic key enzymes of carbohydrate metabolism in streptozotocin induced diabetic rats.
abstract: The aim of the present investigation was to evaluate the anti-diabetic activity of 20-OH-ecdysone on glucose metabolic key enzymes in control and streptozotocin induced diabetic rats. On oral administration of 20-OH-ecdysone at a dose of 5mg/kg body weight per day to diabetic rats for 30 days resulted in a significant decrease in the levels of plasma glucose, glycosylated hemoglobin (HbA1c) and an increase in the levels of insulin and hemoglobin. Administration of 20-OH-ecdysone showed significant increase in the levels of glycolytic enzyme (hexokinase) and hepatic shunt enzyme (glucose-6-phosphate dehydrogenase) whereas significant decrease in the levels of gluconeogenic enzymes (glucose-6-phosphatase and fructose-1,6-bisphosphatase) in diabetic treated rats. Furthermore, protection against body weight loss of diabetic animals also observed. This study indicates that the administration of 20-OH-ecdysone to diabetic rats resulted in alterations in the metabolism of glucose with subsequent reduction in plasma glucose levels. A comparison was made between the action of 20-OH-ecdysone and antidiabetic drug-glibenclamide. The effects produced by the 20-OH-ecdysone were comparable to that of glibenclamide.
authors.affiliation: Department of Medical Biochemistry, Dr ALM P-G, Institute of Basic Medical Sciences, University of Madras, Taramani Campus, Chennai, Tamil Nadu 600113, India.
authors.forename: Ramalingam
authors.initials: R
authors.lastname: Sundaram
authors.forename: Rajendran
authors.initials: R
authors.lastname: Naresh
authors.forename: Palanivelu
authors.initials: P
authors.lastname: Shanthi
authors.forename: Panchanatham
authors.initials: P
authors.lastname: Sachdanandam
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D050260:Carbohydrate Metabolism / Q000187:drug effects*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy / Q000378:metabolism*; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D004441:Ecdysterone / Q000494:pharmacology*; D004798:Enzymes / Q000378:metabolism; D006597:Fructose-Bisphosphatase / Q000378:metabolism; D005952:Glucose-6-Phosphatase / Q000378:metabolism; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006442:Glycated Hemoglobin / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D006593:Hexokinase / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000494:pharmacology; D051381:Rats; D013311:Streptozocin; D020950:Vitex / Q000737:chemistry
chemical_list: D001786:Blood Glucose; D004441:Ecdysterone; D004798:Enzymes; D006597:Fructose-Bisphosphatase; D005952:Glucose-6-Phosphatase; D005954:Glucosephosphate Dehydrogenase; D006442:Glycated Hemoglobin; D006003:Glycogen; D006593:Hexokinase; D007004:Hypoglycemic Agents; D013311:Streptozocin