title: Comparative clinical evaluation of efficacy and safety of a formulation containing ciclopirox 8% in the form of a therapeutic nail lacquer in two different posologies for the treatment of onychomycosis of the toes.
abstract: BACKGROUND
  The use of topical antifungal agents in the treatment of onychomycosis is of great value in clinical practice as there are different limitations regarding the use of systemic treatment.
  
  
  OBJECTIVE
  To evaluate the efficacy and safety of a nail lacquer formulation containing ciclopirox 8% in two different posologies: the traditional regimen (3/2/1) and a regimen of weekly use.
  
  
  METHODS
  A blind, randomized, comparative trial which included 41 patients divided into 02 groups, with Group I using the nail lacquer once weekly and Group II using the traditional regimen (3/2/1). Both groups applied the medication for 06 months.
  
  
  RESULTS
  The species most frequently found in groups I and II were Trichophyton rubrum (55% and 61.9%) and Trichophyton mentagrophytes (30% and 19%). There was a tendency to a higher level of treatment resistance by T. mentagrophytes infection in both groups, without any predilection for sex, age, proportion of the nail affected at the beginning of the study, duration of the clinical disease and quantity of nails affected per person. Both groups had significant levels of mycological cure, clinical response and therapeutic success and there was no statistically significant difference between groups I and II (p >0.05).
  
  
  CONCLUSIONS
  The nail lacquer containing ciclopirox 8% was equally effective at a weekly dose when compared to the traditional dosing (3/2/1), allowing a more comfortable regimen.
authors.affiliation: Medical School of the Universidade de São Paulo, Brazil. sergio@medcinonline.com.br
authors.forename: Sergio
authors.initials: S
authors.lastname: Schalka
authors.forename: Samanta
authors.initials: S
authors.lastname: Nunes
authors.forename: Antonio
authors.initials: A
authors.lastname: Gomes Neto
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D000077768:Ciclopirox; D005260:Female; D005533:Foot Dermatoses / Q000188:drug therapy*; D006801:Humans; D007764:Lacquer; D008297:Male; D008875:Middle Aged; D014009:Onychomycosis / Q000188:drug therapy*; D011728:Pyridones / Q000008:administration & dosage* / Q000627:therapeutic use; D016037:Single-Blind Method; D016896:Treatment Outcome; D014249:Trichophyton / Q000187:drug effects; D055815:Young Adult
chemical_list: D000935:Antifungal Agents; D011728:Pyridones; D000077768:Ciclopirox