title: Treatment of adult soft tissue sarcoma: old concepts, new insights, and potential for drug discovery.
abstract: Soft tissue sarcomas are a heterogeneous group of mesenchymal tumors that vary in their behavior as well as treatment. Certain histologic subtypes predict for response to particular chemotherapy drugs, while molecular genetics not only increasingly aid in the diagnosis but also has an emerging role in the identification of potential targets for drug therapy. Herein we review the varying soft tissue sarcoma subtypes, their staging, and management. Furthermore, improvement in the understanding of novel mechanisms involved in soft tissue sarcomas lends insight into the compelling role of the use of newer agents with promising results that are discussed.
authors.affiliation: Division of Hematology and Oncology, Department of Medicine, George Washington University Medical Center, Washington, District of Columbia 20037, USA. jaragonching@mfa.gwu.edu
authors.forename: Jeanny B
authors.initials: JB
authors.lastname: Aragon-Ching
authors.forename: Robert G
authors.initials: RG
authors.lastname: Maki
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D006801:Humans; D009367:Neoplasm Staging; D012509:Sarcoma / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology*; D012983:Soft Tissue Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology*
chemical_list: D000970:Antineoplastic Agents