title: Concurrent binding and delivery of proteins and lipophilic small molecules using polymeric nanogels.
abstract: Supramolecular nanoassemblies, which are capable of binding and delivering either lipophilic small molecules or hydrophilic molecules, are of great interest. Concurrently binding and delivering this combination of molecules is cumbersome, because of the opposing supramolecular host requirements. We describe the development of a versatile nanoassembly system that is capable of binding and delivering both, a protein and a lipophilic small molecule, simultaneously inside the cells.
authors.affiliation: Department of Chemistry, University of Massachusetts Amherst, Massachusetts 01003, USA.
authors.forename: Daniella C
authors.initials: DC
authors.lastname: González-Toro
authors.forename: Ja-Hyoung
authors.initials: JH
authors.lastname: Ryu
authors.forename: Reuben T
authors.initials: RT
authors.lastname: Chacko
authors.forename: Jiaming
authors.initials: J
authors.lastname: Zhuang
authors.forename: S
authors.initials: S
authors.lastname: Thayumanavan
mesh_terms: D001665:Binding Sites; D005782:Gels / Q000737:chemistry*; D006367:HeLa Cells; D006801:Humans; D008958:Models, Molecular; D053758:Nanoparticles / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry*; D011506:Proteins / Q000737:chemistry*
chemical_list: D005782:Gels; D011108:Polymers; D011506:Proteins