title: Differential relationships of impulsivity or antisocial symptoms on P50, N100, or P200 auditory sensory gating in controls and antisocial personality disorder.
abstract: Limited information is available on the relationship between antisocial personality disorder (ASPD) and early filtering, or gating, of information, even though this could contribute to the repeatedly reported impairment in ASPD of higher-order information processing. In order to investigate early filtering in ASPD, we compared electrophysiological measures of auditory sensory gating assessed by the paired-click paradigm in males with ASPD (n = 37) to healthy controls (n = 28). Stimulus encoding was measured by P50, N100, and P200 auditory evoked potentials; auditory sensory gating (ASG) was measured by a reduction in amplitude of evoked potentials following click repetition. Effects were studied of co-existing past alcohol or drug use disorders, ASPD symptom counts, and trait impulsivity. Controls and ASPD did not differ in P50, N100, or P200 amplitude or ASG. Past alcohol or drug use disorders had no effect. In controls, impulsivity related to improved P50 and P200 gating. In ASPD, P50 or N100 gating was impaired with more symptoms or increased impulsivity, respectively, suggesting impaired early filtering of irrelevant information. In controls the relationship between P50 and P200 gating and impulsivity was reversed, suggesting better gating with higher impulsivity scores. This could reflect different roles of ASG in behavioral regulation in controls versus ASPD.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, University of Texas at Houston, Texas Medical Center, 1941 East Road, Houston, TX 77030, USA. marijn.lijffijt@uth.tmc.edu
authors.forename: Marijn
authors.initials: M
authors.lastname: Lijffijt
authors.forename: Blake
authors.initials: B
authors.lastname: Cox
authors.forename: Michelle D
authors.initials: MD
authors.lastname: Acas
authors.forename: Scott D
authors.initials: SD
authors.lastname: Lane
authors.forename: F Gerard
authors.initials: FG
authors.lastname: Moeller
authors.forename: Alan C
authors.initials: AC
authors.lastname: Swann
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000293:Adolescent; D000328:Adult; D000987:Antisocial Personality Disorder / Q000503:physiopathology*; D001307:Auditory Perception; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D006801:Humans; D007175:Impulsive Behavior / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011930:Reaction Time / Q000502:physiology; D055139:Sensory Gating / Q000502:physiology*; D013223:Statistics as Topic; D055815:Young Adult