title: Chemistry and biological activities of terpenoids from copaiba (Copaifera spp.) oleoresins.
abstract: Copaiba oleoresins are exuded from the trunks of trees of the Copaifera species (Leguminosae-Caesalpinoideae). This oleoresin is a solution of diterpenoids, especially, mono- and di-acids, solubilized by sesquiterpene hydrocarbons. The sesquiterpenes and diterpenes (labdane, clerodane and kaurane skeletons) are different for each Copaifera species and have been linked to several reported biological activities, ranging from anti-tumoral to embriotoxic effects. This review presents all the substances already described in this oleoresin, together with structures and activities of its main terpenoids.
authors.affiliation: Chemistry Department, Amazonas Federal University, Av. Gal. Rodrigo Octávio, 6.200, Japiim, Manaus-AM 69080-900, Brazil.
authors.forename: Lidiam Maia
authors.initials: LM
authors.lastname: Leandro
authors.forename: Fabiano de Sousa
authors.initials: Fde S
authors.lastname: Vargas
authors.forename: Paula Cristina Souza
authors.initials: PC
authors.lastname: Barbosa
authors.forename: Jamilly Kelly Oliveira
authors.initials: JK
authors.lastname: Neves
authors.forename: José Alexsandro
authors.initials: JA
authors.lastname: da Silva
authors.forename: Valdir Florêncio
authors.initials: VF
authors.lastname: da Veiga-Junior
mesh_terms: D000818:Animals; D007887:Fabaceae / Q000737:chemistry*; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D013729:Terpenes / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D010936:Plant Extracts; D013729:Terpenes