title: Reaction based fluorescent probes for hydrogen sulfide.
abstract: A reaction based fluorescence turn-on strategy for hydrogen sulfide (H(2)S) was developed. This strategy was based on a H(2)S-specific Michael addition-cyclization sequence. Other biological thiols such as cysteine and glutathione did not pursue the reaction and therefore did not turn on the fluorescence/consume the substrates. The probes showed good selectivity and sensitivity for hydrogen sulfide.
authors.affiliation: Department of Chemistry, Washington State University, Pullman, Washington 99164, USA.
authors.forename: Chunrong
authors.initials: C
authors.lastname: Liu
authors.forename: Bo
authors.initials: B
authors.lastname: Peng
authors.forename: Sheng
authors.initials: S
authors.lastname: Li
authors.forename: Chung-Min
authors.initials: CM
authors.lastname: Park
authors.forename: A Richard
authors.initials: AR
authors.lastname: Whorton
authors.forename: Ming
authors.initials: M
authors.lastname: Xian
mesh_terms: D002384:Catalysis; D003545:Cysteine / Q000737:chemistry; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000737:chemistry*; D005978:Glutathione / Q000737:chemistry; D006862:Hydrogen Sulfide / Q000032:analysis*; D015394:Molecular Structure; D013438:Sulfhydryl Compounds / Q000737:chemistry
chemical_list: D005456:Fluorescent Dyes; D013438:Sulfhydryl Compounds; D005978:Glutathione; D003545:Cysteine; D006862:Hydrogen Sulfide