title: Rage signalling promotes intestinal tumourigenesis.
abstract: Development of colon cancer is a multistep process that is regulated by intrinsic and extrinsic cellular signals. Extrinsic factors include molecular patterns that are derived from either pathogens (PAMPs) or cellular damage (DAMPs). These molecules can promote tumourigenesis by activation of the innate immune system, but the individual contribution of ligands and their receptors remains elusive. The receptor for advanced glycation end products (Rage) is a pattern recognition receptor that binds multiple ligands derived from a damaged cell environment such as Hmgb1 and S100 protein. Here we show that Rage signalling has a critical role in sporadic development of intestinal adenomas, as Apc(Min/+) Rage(-/-) mice are protected against tumourigenesis.
authors.affiliation: Tytgat Institute for Liver & Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: Heijmans
authors.forename: N V J A
authors.initials: NV
authors.lastname: Büller
authors.forename: E
authors.initials: E
authors.lastname: Hoff
authors.forename: A A
authors.initials: AA
authors.lastname: Dihal
authors.forename: T
authors.initials: T
authors.lastname: van der Poll
authors.forename: M A D
authors.initials: MA
authors.lastname: van Zoelen
authors.forename: A
authors.initials: A
authors.lastname: Bierhaus
authors.forename: I
authors.initials: I
authors.lastname: Biemond
authors.forename: J C H
authors.initials: JC
authors.lastname: Hardwick
authors.forename: D W
authors.initials: DW
authors.lastname: Hommes
authors.forename: V
authors.initials: V
authors.lastname: Muncan
authors.forename: G R
authors.initials: GR
authors.lastname: van den Brink
mesh_terms: D000236:Adenoma / Q000378:metabolism*; D000818:Animals; D007414:Intestinal Neoplasms / Q000378:metabolism*; D051379:Mice; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000378:metabolism*; D051192:Receptors, Pattern Recognition / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic; D051192:Receptors, Pattern Recognition