title: Repeated administration of amitriptyline reduces oxaliplatin-induced mechanical allodynia in rats.
abstract: Oxaliplatin is a key drug in the treatment of colorectal cancer, but it causes acute and chronic neuropathies in patients. Amitriptyline has widely been used in patients with painful neuropathy. In this study, we investigated the effect of amitriptyline on the oxaliplatin-induced neuropathy in rats. Repeated administration of amitriptyline (5 and 10 mg/kg, p.o., once a day) reduced the oxaliplatin-induced mechanical allodynia but not cold hyperalgesia and reversed the oxaliplatin-induced increase in the expression of NR2B protein and mRNA in rat spinal cord. These results suggest that amitriptyline is useful for the treatment of oxaliplatin-induced neuropathy clinically.
authors.affiliation: Department of Pharmacy, Kyushu University Hospital, Fukuoka, Japan.
authors.forename: Hikaru
authors.initials: H
authors.lastname: Sada
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Egashira
authors.forename: Soichiro
authors.initials: S
authors.lastname: Ushio
authors.forename: Takehiro
authors.initials: T
authors.lastname: Kawashiri
authors.forename: Masafumi
authors.initials: M
authors.lastname: Shirahama
authors.forename: Ryozo
authors.initials: R
authors.lastname: Oishi
mesh_terms: D000639:Amitriptyline / Q000008:administration & dosage*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006930:Hyperalgesia / Q000139:chemically induced* / Q000188:drug therapy*; D008297:Male; D009944:Organoplatinum Compounds / Q000037:antagonists & inhibitors / Q000633:toxicity*; D000077150:Oxaliplatin; D010147:Pain Measurement / Q000187:drug effects / Q000379:methods; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D000639:Amitriptyline