title: The role of gene expression profiling in the management of breast cancer patients.
abstract: Breast cancer specialists often find it difficult to decide whether or not to recommend on chemotherapy in women with presumed low risk for future development of metastatic disease. This decision is usually based on well-established clinical and histopathological scoring tools. During recent years, an additional way to estimate the risk for advanced disease comes from gene expression profiling of the breast cancer tumor cells. Such diagnostic tests are already in the market and relevant data are quickly accumulating. This article reviews the principles of this innovative prognostic system and brings data from the latest clinical trials.
authors.affiliation: Tel-Aviv University Sackler School of Medicine, Tel Aviv, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Pines
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents; D001943:Breast Neoplasms / Q000145:classification / Q000235:genetics* / Q000628:therapy*; D017024:Chemotherapy, Adjuvant; D005260:Female; D020869:Gene Expression Profiling; D006801:Humans; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis; D012307:Risk Factors
chemical_list: D000970:Antineoplastic Agents; D018719:Erb-b2 Receptor Tyrosine Kinases; C508053:ERBB2 protein, human