title: Semisyngeneic hybrid resistance to murine teratocarcinoma cells.
abstract: Resistance to two cultured lines of murine embryonal carcinoma was studied in F1 hybrids constructed between the tumor-syngeneic mouse strain 129/J and several allogeneic strains. Three of four such hybrid strains were significantly more resistant to the multipotent embryonal carcinoma line PCC3 than the tumor-syngeneic 129/J parent strain. All hybrid strains tested showed significantly higher resistance to the nullipotent embryonal carcinoma line F9 than the syngeneic strain. Hybrid resistance to embryonal carcinoma lines does not require a hybrid H-2 complex. Several kinds of evidence indicate that this hybrid resistance has an immunological basis.
authors.affiliation: McArdle Laboratory for Cancer Research, The University of Wisconsin. Madison, Wisconsin 53706, USA.
authors.forename: G A
authors.initials: GA
authors.lastname: Bishop
authors.forename: W F
authors.initials: WF
authors.lastname: Dove
mesh_terms: D000818:Animals; D018236:Carcinoma, Embryonal / Q000276:immunology*; D002460:Cell Line; D045744:Cell Line, Tumor; D002678:Chimera / Q000276:immunology; D004307:Dose-Response Relationship, Radiation; D006183:H-2 Antigens / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018243:Teratocarcinoma / Q000276:immunology*; D014916:Whole-Body Irradiation
chemical_list: D006183:H-2 Antigens