title: Chemical and bioactivity evaluation of the bark of Neonauclea purpurea.
abstract: Bioassay-guided fractionation of the MeOH extract from the stem bark of Neonauclea purpurea used in traditional medicine, resulted in the isolation of 2 indole alkaloids, cadambine (1) and alpha-dihydrocadambine (2), as well as a quinolic compound, 2,6-dimethoxy-1,4-benzoquinone (3). Antimalarial activity evaluation showed that compounds 2 and 3 exhibited mild in vitro antimalarial activity against Plasmodium falciparum, the chloroquine-resistant strain K1 with IC50 values of 6.6 and 11.3 microM, respectively. Compounds 1 and 2 showed no cytotoxicity to monkey (Vero) cells, but compound 3 showed weak cytotoxicity with an IC50 value of 1.19 microM.
authors.affiliation: Department of Biotechnology, Faculty of Science, Mahidol University, Bangkok 10400, Thailand.
authors.forename: Netiya
authors.initials: N
authors.lastname: Karaket
authors.forename: Kanyaratt
authors.initials: K
authors.lastname: Supaibulwatana
authors.forename: Supatsara
authors.initials: S
authors.lastname: Ounsuk
authors.forename: Valérie
authors.initials: V
authors.lastname: Bultel-Poncé
authors.forename: Van Cuong
authors.initials: VC
authors.lastname: Pham
authors.forename: Bernard
authors.initials: B
authors.lastname: Bodo
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology; D002522:Chlorocebus aethiops; D026121:Indole Alkaloids / Q000737:chemistry* / Q000494:pharmacology*; D024301:Plant Bark / Q000737:chemistry*; D018547:Plant Stems / Q000737:chemistry; D010963:Plasmodium falciparum / Q000187:drug effects; D019666:Rubiaceae / Q000737:chemistry*; D014709:Vero Cells
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D000962:Antimalarials; D026121:Indole Alkaloids