title: High beam current operation of a PETtrace™ cyclotron for 18F- production.
abstract: Upgrades and optimisation achieved 160 μA total target current operation of a GE PETtrace cyclotron in dual target mode for the routine production of [(18)F]FDG for >2 years. Approximately 900 GBq of (18)F(-) and >500 GBq of [(18)F]FDG can be produced routinely in a single production run, meeting the routine [(18)F]FDG requirements with our customer base and achieving economies of scale. Production of >1 TBq of (18)F(-) in a single run was achieved. Reliability, saturation and synthesis yields were not adversely affected.
authors.affiliation: Department of PET and Nuclear Medicine, Royal Prince Alfred Hospital, Camperdown, NSW 2050, Australia. eberl@staff.usyd.edu.au
authors.forename: S
authors.initials: S
authors.lastname: Eberl
authors.forename: T
authors.initials: T
authors.lastname: Eriksson
authors.forename: O
authors.initials: O
authors.lastname: Svedberg
authors.forename: J
authors.initials: J
authors.lastname: Norling
authors.forename: D
authors.initials: D
authors.lastname: Henderson
authors.forename: P
authors.initials: P
authors.lastname: Lam
authors.forename: M
authors.initials: M
authors.lastname: Fulham
mesh_terms: D017357:Cyclotrons; D004867:Equipment Design; D019544:Equipment Failure Analysis; D019788:Fluorodeoxyglucose F18 / Q000138:chemical synthesis* / Q000528:radiation effects; D007553:Isotope Labeling / Q000295:instrumentation*; D008422:Materials Testing; D049268:Positron-Emission Tomography / Q000295:instrumentation*; D011829:Radiation Dosage; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18