title: Central nervous system drug consumption depending on the time between symptom onset and the diagnosis of Alzheimer's disease: an analysis by the Registry of Dementias of Girona.
abstract: OBJECTIVE
  To describe central nervous system (CNS) drug consumption patterns depending on the time to diagnosis of Alzheimer's disease (AD), and to check whether the cases diagnosed later are associated with greater severity and consuming more CNS drugs.
  
  
  METHODS
  Cross-sectional study using 952 cases of the Registry of Dementias of Girona. A binary logistic regression was used to detect variables associated with the use of CNS drugs depending on the time to diagnosis.
  
  
  RESULTS
  CNS drugs were consumed by 95.8% of the AD patients. Only antipsychotics presented a statistically significant increase in the frequency of prescription to patients with longer time elapsed from symptom onset to AD diagnosis.
  
  
  CONCLUSIONS
  Longer time elapsed from the onset of symptoms to the diagnosis resulted in increased probability of antipsychotic consumption.
authors.affiliation: Research Unit, Institut d'Assistència Sanitària, Hospital Universitari Dr. Josep Trueta, Girona, Spain.
authors.forename: Laia
authors.initials: L
authors.lastname: Calvó-Perxas
authors.forename: Secundino
authors.initials: S
authors.lastname: López-Pousa
authors.forename: Joan
authors.initials: J
authors.lastname: Vilalta-Franch
authors.forename: Oriol
authors.initials: O
authors.lastname: Turró-Garriga
authors.forename: Michael
authors.initials: M
authors.lastname: Blankenburg
authors.forename: Laia
authors.initials: L
authors.lastname: Febrer
authors.forename: Margarida
authors.initials: M
authors.lastname: Flaqué
authors.forename: Natàlia
authors.initials: N
authors.lastname: Vallmajó
authors.forename: Maria
authors.initials: M
authors.lastname: Aguirregomozcorta
authors.forename: David
authors.initials: D
authors.lastname: Genís
authors.forename: Isabel
authors.initials: I
authors.lastname: Casas
authors.forename: Héctor
authors.initials: H
authors.lastname: Perkal
authors.forename: Joan
authors.initials: J
authors.lastname: Coromina
authors.forename: Josep
authors.initials: J
authors.lastname: Garre-Olmo
mesh_terms: D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000175:diagnosis / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects; D002490:Central Nervous System / Q000187:drug effects*; D003430:Cross-Sectional Studies; D011307:Drug Prescriptions / Q000706:statistics & numerical data; D042241:Early Diagnosis; D005260:Female; D015577:Geriatric Assessment / Q000379:methods; D006306:Health Surveys / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D012042:Registries / Q000706:statistics & numerical data; D012959:Socioeconomic Factors; D013030:Spain / Q000453:epidemiology; D013997:Time Factors
chemical_list: D014150:Antipsychotic Agents