title: Hepatosplenic candidiasis in the era of new antifungal drugs: a study in Paris 2000-2007.
abstract: We report a retrospective study of 24 patients with haematological malignancy and hepatosplenic candidiasis. Clinical and biological features were similar to previous reports. No patient previously received antifungal prophylaxis. Liver or spleen histological examination revealed yeasts in 6/24 patients (25%) on direct examination but all cultures were negative. After a median duration of 7 months, antifungal treatment was discontinued in 58% of the patients with no relapse. Eleven (46%) patients died during follow up. After multivariate analysis, independent factors associated with death were the duration of neutropenia (p 0.022) and relapsing haematological malignancy (p 0.015).
authors.affiliation: Department of Infectious Diseases, AP-HP Hôpital Saint-Louis, Denis Diderot - Paris 7 University, France. nathalie.de-castro@sls.aphp.fr
authors.forename: N
authors.initials: N
authors.lastname: De Castro
authors.forename: E
authors.initials: E
authors.lastname: Mazoyer
authors.forename: R
authors.initials: R
authors.lastname: Porcher
authors.forename: E
authors.initials: E
authors.lastname: Raffoux
authors.forename: F
authors.initials: F
authors.lastname: Suarez
authors.forename: P
authors.initials: P
authors.lastname: Ribaud
authors.forename: O
authors.initials: O
authors.lastname: Lortholary
authors.forename: J-M
authors.initials: JM
authors.lastname: Molina
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000627:therapeutic use*; D058365:Candidiasis, Invasive / Q000188:drug therapy* / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D016469:Fungemia / Q000188:drug therapy* / Q000453:epidemiology*; D019337:Hematologic Neoplasms / Q000150:complications; D006651:Histocytochemistry; D006801:Humans; D008099:Liver / Q000473:pathology; D008107:Liver Diseases / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D010297:Paris / Q000453:epidemiology; D012189:Retrospective Studies; D013154:Spleen / Q000473:pathology; D013158:Splenic Diseases / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology; D016019:Survival Analysis; D055815:Young Adult
chemical_list: D000935:Antifungal Agents