title: Cohesin in determining chromosome architecture.
abstract: Cells use ring-like structured protein complexes for various tasks in DNA dynamics. The tripartite cohesin ring is particularly suited to determine chromosome architecture, for it is large and dynamic, may acquire different forms, and is involved in several distinct nuclear processes. This review focuses on cohesin's role in structuring chromosomes during mitotic and meiotic cell divisions and during interphase.
authors.affiliation: Cell Biology & Biophysics Unit, European Molecular Biology Laboratory, Heidelberg, Germany. christian.haering@embl.de
authors.forename: Christian H
authors.initials: CH
authors.lastname: Haering
authors.forename: Rolf
authors.initials: R
authors.lastname: Jessberger
mesh_terms: D000818:Animals; D018797:Cell Cycle Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D002467:Cell Nucleus / Q000235:genetics / Q000378:metabolism / Q000648:ultrastructure; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D002875:Chromosomes / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism / Q000648:ultrastructure; D006801:Humans; D007399:Interphase / Q000235:genetics / Q000502:physiology; D008540:Meiosis / Q000235:genetics / Q000502:physiology; D008938:Mitosis / Q000235:genetics / Q000502:physiology; D008954:Models, Biological; D009690:Nucleic Acid Conformation; D012854:Sister Chromatid Exchange / Q000235:genetics / Q000502:physiology; D000097722:Cohesins
chemical_list: D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D000097722:Cohesins