title: The effects of selenium and vitamin E on lung tissue in rats with sepsis.
abstract: OBJECTIVE
  In this study we examined the ability of selenium and vitamin E to prevent sepsis-induced changes in lung tissue.
  
  
  METHODS
  Fifty rats were divided into five groups: Group 1: Control group; Group 2: Sepsis group. In this group only cecal ligation and perforation (CLP) was performed. Group 3: Selenium group. An intraperitoneal dose of 100 µg selenium was given for the first two days followed by a daily dose of 40 µg for the next five days. CLP was performed the following day. Group 4: Selenium and vitamin E group. In addition to selenium, vitamin E was given intramuscularly in a dose of 250 mg/kg/day for seven days. CLP was performed the following day. Group 5: Vitamin E group. Vitamin E was given intramuscularly in a dose of 250 mg/kg/day for seven days. CLP was performed the following day.
  
  
  RESULTS
  There were significant differences between Group 2 and all other groups in terms of blood gas values (pH, pCO2, SaO2), and leukocyte, C-reactive protein (CRP) and glutathione peroxidase levels (p < 0.005). There was no statistically significant difference between groups 3, 4 and 5 in terms of histopathological changes in lung tissue (p > 0.05), but all groups were significantly different compared with Group 2 (p < 0.05).
  
  
  CONCLUSIONS
  Sepsis-induced lung tissue damage can be reduced or prevented by pre-treatment with of selenium and/or vitamin E in a rat model.
authors.affiliation: Konya Numune Hospital General Surgery.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Atli
authors.forename: Mehmet
authors.initials: M
authors.lastname: Erikoglu
authors.forename: Adnan
authors.initials: A
authors.lastname: Kaynak
authors.forename: Haci H
authors.initials: HH
authors.lastname: Esen
authors.forename: Sevil
authors.initials: S
authors.lastname: Kurban
mesh_terms: D000818:Animals; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D008168:Lung / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012643:Selenium / Q000627:therapeutic use*; D018805:Sepsis / Q000188:drug therapy* / Q000378:metabolism / Q000517:prevention & control*; D014810:Vitamin E / Q000627:therapeutic use*
chemical_list: D014810:Vitamin E; D005979:Glutathione Peroxidase; D012643:Selenium