title: A possible mechanism of renal cell death after ischemia/reperfusion.
abstract: Linkermann et al. provide the first evidence for a possible biochemical mechanism of necrotic kidney cell death associated with renal ischemia/reperfusion-induced acute kidney injury. The mechanisms of several pathways resulting in programmed necrosis were recently elucidated and rely on receptor-interacting protein kinases 1 and 3. Using an inhibitor of one of these kinases, Linkermann et al. were able to ameliorate functional and morphologic kidney damage after ischemia/reperfusion.
authors.affiliation: Department of Internal Medicine and Central Arkansas Veterans Healthcare System, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA. PricePeterM@uams.edu
authors.forename: Peter M
authors.initials: PM
authors.lastname: Price
authors.forename: Rawad
authors.initials: R
authors.lastname: Hodeify
mesh_terms: D000818:Animals; D006801:Humans; D007668:Kidney / Q000293:injuries*; D008297:Male; D053422:Receptor-Interacting Protein Serine-Threonine Kinases / Q000502:physiology*; D015427:Reperfusion Injury / Q000201:enzymology* / Q000473:pathology*
chemical_list: D053422:Receptor-Interacting Protein Serine-Threonine Kinases; C506251:Ripk1 protein, mouse