title: Intestinal healing in rats submitted to ethanol ingestion.
abstract: OBJECTIVE
  To study the effect of alcoholism on intestinal healing and postoperative complications in rats
  
  
  METHODS
  One hundred and sixty rats were divided into two groups: control and treated. The control group received water and the treated group 30% ethanol. After 180 days, colotomy with anastomosis were performed. After, the groups were divided into four subgroups: 20 rats for study at the following moments: 4(th), 7(th), 14(th) and 21(st) postoperative. The analyzed parameters were: weight gain, breaking strength, tissue hydroxyproline, postoperative complications and histopathological study
  
  
  RESULTS
  Weight gain was greater in the control group (p<0.05). When all the subgroups were clustered, breaking strength was significantly greater in the control (p<0.05). Histopathology and hydroxyproline dosage did not show differences. There were five surgical site infections in the treated group while the control group showed two (p>0.05). Nine fistulas occurred in the treated group whereas the control group two (p<0.05). There were three deaths in the control group and seven in the treated group (p>0.05).
  
  
  CONCLUSIONS
  Treated group undergo a malnutrition process that is revealed by lower weight gain. Impaired intestinal healing as indicated by smaller breaking strength. There were a larger number of postoperative complications in the treated animals.
authors.affiliation: Division of Gastroenterology Surgery, Surgery and Orthopedics Department, Botucatu School of Medicine, UNESP, Brazil. rodrigomacarena@yahoo.com.br
authors.forename: Rodrigo Severo de Camargo
authors.initials: RS
authors.lastname: Pereira
authors.forename: Cláudia Nishida
authors.initials: CN
authors.lastname: Hasimoto
authors.forename: Leonardo
authors.initials: L
authors.lastname: Pelafsky
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Llanos
authors.forename: Daniele Cristina
authors.initials: DC
authors.lastname: Cataneo
authors.forename: César Tadeu
authors.initials: CT
authors.lastname: Spadella
authors.forename: José Guilherme
authors.initials: JG
authors.lastname: Minossi
mesh_terms: D000437:Alcoholism / Q000150:complications*; D000714:Anastomosis, Surgical / Q000009:adverse effects; D000818:Animals; D016009:Chi-Square Distribution; D003106:Colon / Q000601:surgery*; D004195:Disease Models, Animal; D000431:Ethanol / Q000008:administration & dosage*; D007412:Intestinal Fistula / Q000209:etiology*; D044342:Malnutrition / Q000209:etiology; D010538:Peritonitis / Q000209:etiology*; D011184:Postoperative Period; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013529:Surgical Wound Dehiscence / Q000503:physiopathology; D013530:Surgical Wound Infection / Q000209:etiology; D013718:Tensile Strength / Q000502:physiology; D015430:Weight Gain / Q000502:physiology; D014945:Wound Healing / Q000502:physiology*
chemical_list: D000431:Ethanol