title: Enantioselective activation of stable carboxylate esters as enolate equivalents via N-heterocyclic carbene catalysts.
abstract: The first N-Heterocyclic Carbene (NHC) mediated activation of stable carboxylate esters to generate enolate intermediates is disclosed. The catalytically generated arylacetic ester enolates undergo enantioselective reactions with α,β-unsaturated imines.
authors.affiliation: Division of Chemistry & Biological Chemistry, School of Physical & Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore.
authors.forename: Lin
authors.initials: L
authors.lastname: Hao
authors.forename: Yu
authors.initials: Y
authors.lastname: Du
authors.forename: Hui
authors.initials: H
authors.lastname: Lv
authors.forename: Xingkuan
authors.initials: X
authors.lastname: Chen
authors.forename: Huishen
authors.initials: H
authors.lastname: Jiang
authors.forename: Yaling
authors.initials: Y
authors.lastname: Shao
authors.forename: Yonggui Robin
authors.initials: YR
authors.lastname: Chi
mesh_terms: D002264:Carboxylic Acids / Q000737:chemistry*; D002384:Catalysis; D004952:Esters; D006571:Heterocyclic Compounds / Q000737:chemistry*; D007097:Imines / Q000737:chemistry*; D008697:Methane / Q000031:analogs & derivatives* / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D002264:Carboxylic Acids; D004952:Esters; D006571:Heterocyclic Compounds; D007097:Imines; C030011:carbene; D008697:Methane