title: Limbic encephalitis and type 1 diabetes with glutamic acid decarboxylase 65 (GAD65) autoimmunity: improvement with high-dose intravenous immunoglobulin therapy.
abstract: Glutamic acid decarboxylase antibodies (GAD-abs) are an immunological factor involved in type 1 diabetes and other diseases involving the central nervous system. This report is of a patient with type 1 diabetes and a rare case of non-paraneoplastic limbic encephalitis mediated by anti-GAD65 antibodies that improved with the use of immunosuppressive drugs.
authors.affiliation: Post-Emergency Unit, Department of Internal Medicine, Hôpital Avicenne, 125, route de Stalingrad, 93009 Bobigny cedex, France. marilucy.lopez-sublet@avc.aphp.fr
authors.forename: M
authors.initials: M
authors.lastname: Lopez-Sublet
authors.forename: H
authors.initials: H
authors.lastname: Bihan
authors.forename: G
authors.initials: G
authors.lastname: Reach
authors.forename: S
authors.initials: S
authors.lastname: Dupont
authors.forename: A
authors.initials: A
authors.lastname: Didelot
authors.forename: J-J
authors.initials: JJ
authors.lastname: Mourad
authors.forename: A
authors.initials: A
authors.lastname: Krivitzky
authors.forename: R
authors.initials: R
authors.lastname: Dhote
mesh_terms: D000328:Adult; D015551:Autoimmunity; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000188:drug therapy / Q000276:immunology*; D005260:Female; D005968:Glutamate Decarboxylase / Q000276:immunology*; D006801:Humans; D007116:Immunization, Passive / Q000379:methods*; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage*; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D020363:Limbic Encephalitis / Q000188:drug therapy / Q000276:immunology*; D008279:Magnetic Resonance Imaging; D009483:Neuropsychological Tests; D016896:Treatment Outcome
chemical_list: D016756:Immunoglobulins, Intravenous; D007166:Immunosuppressive Agents; D005968:Glutamate Decarboxylase; C401141:glutamate decarboxylase 2