title: Antiparkinsonian properties of a nerve growth factor dipeptide mimetic GK-2 in in vivo experiments.
abstract: An intraperitoneal injection of GK-2 (dipeptide mimetic of nerve growth factor, 0.01-5.00 mg/kg) 24 h before the adverse exposure reduced the severity of haloperidol-induced catalepsy in rats. This agent retained the activity after oral administration in a dose of 10 mg/kg. An intraperitoneal injection of GK-2 in a dose of 1 mg/kg reduced the severity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonian syndrome in mice. Administration of GK-2 45 min after haloperidol treatment was also followed by a decrease in the degree of catalepsy. The repeated intraperitoneal treatment with GK-2 in a dose of 1 mg/kg after intrastriatal injection of 6-hydroxydopamine was shown to prevent the development of apomorphine-induced rotations in rats.
authors.affiliation: V. V. Zakusov Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: P Yu
authors.initials: PY
authors.lastname: Povarnina
authors.forename: T A
authors.initials: TA
authors.lastname: Gudasheva
authors.forename: O N
authors.initials: ON
authors.lastname: Vorontsova
authors.forename: N A
authors.initials: NA
authors.lastname: Bondarenko
authors.forename: S B
authors.initials: SB
authors.lastname: Seredenin
mesh_terms: D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000494:pharmacology*; D000818:Animals; D000978:Antiparkinson Agents / Q000627:therapeutic use*; D002375:Catalepsy / Q000139:chemically induced / Q000188:drug therapy*; D004151:Dipeptides / Q000627:therapeutic use*; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D016627:Oxidopamine / Q000494:pharmacology*; D020734:Parkinsonian Disorders / Q000139:chemically induced / Q000188:drug therapy*; D051381:Rats
chemical_list: D000978:Antiparkinson Agents; D004151:Dipeptides; C572946:bis(N-succinyl-glutamyllysin)hexamethylenediamine; D016627:Oxidopamine; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D006220:Haloperidol