title: Age of recipient and number of doses differentially impact human B and T cell immune memory responses to HPV vaccination.
abstract: Vaccination is one of the most effective medical interventions. However, optimization of existing as well as design of new vaccines is still mostly conducted empirically; a rational approach to vaccine design is largely prohibited by the lack of insight into the relevant mechanisms underlying immune-mediated protection. To delineate the impact of variables on immune memory formation following vaccination, we took advantage of a trial assessing the role of the age of the recipient and the number of administered doses of the quadrivalent HPV vaccine in a well-characterized longitudinal cohort of girls and young women. We found that age of the recipient and the number of doses administered differentially impact the development of B and T cell memory. Specifically, age of the recipient significantly impacted generation of HPV 18-specific B cell memory, while the number of vaccine doses displayed a significant effect on the development of HPV-specific T cell memory. Our data indicate that rational design of vaccines has to be tailored according to the desired induction of B and/or T cell memory.
authors.affiliation: Experimental Medicine Program, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
authors.forename: Kinga K
authors.initials: KK
authors.lastname: Smolen
authors.forename: Laura
authors.initials: L
authors.lastname: Gelinas
authors.forename: Lisa
authors.initials: L
authors.lastname: Franzen
authors.forename: Simon
authors.initials: S
authors.lastname: Dobson
authors.forename: Meena
authors.initials: M
authors.lastname: Dawar
authors.forename: Gina
authors.initials: G
authors.lastname: Ogilvie
authors.forename: Mel
authors.initials: M
authors.lastname: Krajden
authors.forename: Edgardo S
authors.initials: ES
authors.lastname: Fortuno
authors.forename: Tobias R
authors.initials: TR
authors.lastname: Kollmann
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001402:B-Lymphocytes / Q000276:immunology*; D002648:Child; D015331:Cohort Studies; D005260:Female; D000068857:Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18; D006801:Humans; D008137:Longitudinal Studies; D030361:Papillomavirus Infections / Q000276:immunology* / Q000517:prevention & control*; D053918:Papillomavirus Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D014611:Vaccination / Q000379:methods*; D055815:Young Adult
chemical_list: D000068857:Human Papillomavirus Recombinant Vaccine Quadrivalent, Types 6, 11, 16, 18; D053918:Papillomavirus Vaccines