title: Active control of silver nanoparticles spacing using dielectrophoresis for surface-enhanced Raman scattering.
abstract: We demonstrate an active microfluidic platform that integrates dielectrophoresis for the control of silver nanoparticles spacing, as they flow in a liquid channel. By careful control of the nanoparticles spacing, we can effectively increase the surface-enhanced Raman scattering (SERS) signal intensity based on augmenting the number of SERS-active hot-spots, while avoiding irreversible aggregation of the particles. The system is benchmarked using dipicolinate (2,6-pyridinedicarboxylic acid) (DPA), which is a biomarker of Bacillus anthracis. The validity of the results is discussed using several complementing characterization scenarios.
authors.affiliation: School of Electrical and Computer Engineering, RMIT University, Melbourne, Victoria, Australia. af.chrimes@ieee.org
authors.forename: Adam F
authors.initials: AF
authors.lastname: Chrimes
authors.forename: Khashayar
authors.initials: K
authors.lastname: Khoshmanesh
authors.forename: Paul R
authors.initials: PR
authors.lastname: Stoddart
authors.forename: Aminuddin A
authors.initials: AA
authors.lastname: Kayani
authors.forename: Arnan
authors.initials: A
authors.lastname: Mitchell
authors.forename: Hemant
authors.initials: H
authors.lastname: Daima
authors.forename: Vipul
authors.initials: V
authors.lastname: Bansal
authors.forename: Kourosh
authors.initials: K
authors.lastname: Kalantar-zadeh
mesh_terms: D001408:Bacillus anthracis / Q000302:isolation & purification; D046209:Electrophoresis, Microchip / Q000295:instrumentation*; D004867:Equipment Design; D053758:Nanoparticles / Q000737:chemistry*; D010848:Picolinic Acids; D011725:Pyridines / Q000032:analysis*; D012680:Sensitivity and Specificity; D012834:Silver / Q000737:chemistry*; D013059:Spectrum Analysis, Raman / Q000295:instrumentation*
chemical_list: D010848:Picolinic Acids; D011725:Pyridines; D012834:Silver; C004860:dipicolinic acid