title: Triazine dendrimers as drug delivery systems: from synthesis to therapy.
abstract: The use of triazine dendrimers as drug delivery systems benefits from their synthetic versatility and well-defined structure. Triazine dendrimers can be designed and readily synthesized to display orthogonally functional surfaces that facilitate post-synthetic manipulation such as attachment of drug, PEGylation, and/or the installation of ligands or reporting groups. The synthesis is scalable, and large generations can be accessed. To date, triazine dendrimers have been probed for a variety of medicinal applications including drug delivery with an emphasis on cancer, nonviral DNA and RNA delivery systems, in sensing applications, and as bioactive materials. Specifically, triazine adducts with paclitaxel, camptothecin, brefeldin A, and desferrioxamine have been prepared and assessed. Paclitaxel constructs show promising activity in vivo. The use of these materials in fluorescence-based glucose sensors is being pursued. Glycosylated triazine dendrimers interfere with signal transduction in the Toll-4 receptor pathway.
authors.affiliation: Department of Chemistry, Texas Christian University, Fort Worth, TX 76129, USA.
authors.forename: Jongdoo
authors.initials: J
authors.lastname: Lim
authors.forename: Eric E
authors.initials: EE
authors.lastname: Simanek
mesh_terms: D000818:Animals; D050091:Dendrimers / Q000737:chemistry* / Q000494:pharmacology*; D016503:Drug Delivery Systems / Q000379:methods*; D018014:Gene Transfer Techniques; D006801:Humans; D051197:Toll-Like Receptor 4 / Q000378:metabolism; D014227:Triazines / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D050091:Dendrimers; D051197:Toll-Like Receptor 4; D014227:Triazines