title: Biomimetic catalytic enantioselective decarboxylative aldol reaction of β-ketoacids with trifluoromethyl ketones.
abstract: We disclose an organocatalyzed enantioselective decarboxylative ketone aldol reaction of β-ketoacids with trifluoromethyl ketones in the presence of biscinchona alkaloid (DHQD)(2)AQN, affording chiral tertiary alcohols in up to 98% yield and 90% ee.
authors.affiliation: Department of Chemistry, Tianjin University, Tianjin 300072, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zheng
authors.forename: Heng-Ying
authors.initials: HY
authors.lastname: Xiong
authors.forename: Jing
authors.initials: J
authors.lastname: Nie
authors.forename: Ming-Qing
authors.initials: MQ
authors.lastname: Hua
authors.forename: Jun-An
authors.initials: JA
authors.lastname: Ma
mesh_terms: D032701:Biomimetics / Q000379:methods*; D002384:Catalysis; D007651:Keto Acids / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D007651:Keto Acids; D007659:Ketones