title: [Osteoporosis in liver cirrhosis].
abstract: Osteoporosis is a common complication of chronic liver disease, especially in the final stages. This entity is more critical in liver transplant recipients, when bone loss accelerates during the immediate postoperative period. The main mechanism involved in the development of osteoporosis in liver disease is deficient bone formation due to the harmful effects of substances such as bilirubin and bile acids or the toxic effect of alcohol or iron on osteoblasts. To prevent and treat osteoporosis, good nutrition and calcium and vitamin D supplementation are required. There are no specific recommendations on drug treatment but bisphosphonates are effective in increasing bone mass in patients with chronic cholestasis and have a good safety profile.
authors.affiliation: Servicio de Reumatología, Unidad de Hepatología, Centro de Investigación Biomédica en Red de enfermedades hepáticas y digestivas, Insititut d'Investigacions Biomèdiques August Pi i Sunyer, Hospital Clínic, Universidad de Barcelona, España. nguanabens@ub.edu
authors.forename: Núria
authors.initials: N
authors.lastname: Guañabens
authors.forename: Albert
authors.initials: A
authors.lastname: Parés
mesh_terms: D001647:Bile Acids and Salts / Q000378:metabolism / Q000494:pharmacology; D001663:Bilirubin / Q000378:metabolism / Q000494:pharmacology; D050071:Bone Density Conservation Agents / Q000627:therapeutic use; D002118:Calcium / Q000627:therapeutic use; D002478:Cells, Cultured / Q000187:drug effects; D016207:Cytokines / Q000502:physiology; D004967:Estrogens / Q000627:therapeutic use; D005260:Female; D005544:Forecasting; D005598:Fractures, Spontaneous / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications* / Q000503:physiopathology; D008297:Male; D010006:Osteoblasts / Q000187:drug effects; D010012:Osteogenesis / Q000187:drug effects; D010024:Osteoporosis / Q000188:drug therapy / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control; D015995:Prevalence; D014807:Vitamin D / Q000627:therapeutic use
chemical_list: D001647:Bile Acids and Salts; D050071:Bone Density Conservation Agents; D016207:Cytokines; D004967:Estrogens; D014807:Vitamin D; D001663:Bilirubin; D002118:Calcium