title: Dermatologic manifestations in inflammatory bowel disease in Tunisia.
abstract: BACKGROUND
  Cutaneous manifestations are the most common extra intestinal manifestations associated with inflammatory bowel disease (IBD).
  
  
  OBJECTIVE
  To assess the epidemio-clinical profile of skin manifestations in IBD.
  
  
  METHODS
  A prospective and descriptive study was conducted. We have examined skin, mucosa, hair and nails, of all patients with an IBD during one year.
  
  
  RESULTS
  One hundred-ninety-five patients were included. Crohn's disease (CD) was noted in 154 cases (79.8%), ulcerous rectocolitis (UC) in 39 cases (21.2%) and inclassable IBD in 2 cases. Cutaneous manifestations were found in 91% of Crohn's patients and in 92% of UC patients. Granulomatous perianal skin lesions were the main cutaneous manifestations of CD (53%). The most common affected sites were ano-perineal fistulae, perianal and perineal fissures and oedematous and infiltrated perianal and genital plaques. Reactive lesions (Erythema nodosum, Pyoderma gangrenosum, Aphthous stomatitis) were noted in 14 cases. Skin manifestations due to malabsorption were also frequently observed (101 cases: 51.7%).Other dermatoses implicating various mechanisms such as psoriasis, alopecia areata, vitiligo, rosacea, lichen planus, were also noted. Adverse skin manifestations due to treatment (folliculitis, acne, macula-papular rash and DRESS syndrome) were present in 16 cases.
  
  
  CONCLUSIONS
  Our series is characterized by a high frequency of cutaneous manifestations associated to IBD. A better recognition of these skin manifestations by the physician may improve their management.
authors.affiliation: Dermatology, La Rabta Hospital,Tunis.
authors.forename: Amel
authors.initials: A
authors.lastname: Mebazaa
authors.forename: Amina
authors.initials: A
authors.lastname: Aounallah
authors.forename: Narjess
authors.initials: N
authors.lastname: Naija
authors.forename: Rim
authors.initials: R
authors.lastname: Cheikh Rouhou
authors.forename: Lamia
authors.initials: L
authors.lastname: Kallel
authors.forename: Dalenda
authors.initials: D
authors.lastname: El Euch
authors.forename: Jalel
authors.initials: J
authors.lastname: Boubaker
authors.forename: Mourad
authors.initials: M
authors.lastname: Mokni
authors.forename: Azza
authors.initials: A
authors.lastname: Filali
authors.forename: Amel
authors.initials: A
authors.lastname: Ben Osman
mesh_terms: D000328:Adult; D003424:Crohn Disease / Q000150:complications / Q000453:epidemiology; D004893:Erythema Nodosum / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications* / Q000453:epidemiology*; D008286:Malabsorption Syndromes / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D008297:Male; D008875:Middle Aged; D017511:Pyoderma Gangrenosum / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D012871:Skin Diseases / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology*; D013281:Stomatitis, Aphthous / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D014416:Tunisia / Q000453:epidemiology; D055815:Young Adult