title: A molecular doorstop ensures a trickle through translational repression.
abstract: Switching mRNA translation off and on is central to regulated gene expression, but what mechanisms moderate the extent of switch-off? Yao et al. describe how basal expression from interferon-gamma-induced transcripts is maintained during mRNA-specific translational repression. This antagonistic mechanism utilizes a truncated RNA-binding factor generated by a unique alternative polyadenylation event.
authors.affiliation: MRC Centre for Reproductive Health, Queen's Medical Research Institute, University of Edinburgh, Edinburgh EH16 4TJ, Scotland, UK.
authors.forename: Matthew
authors.initials: M
authors.lastname: Brook
authors.forename: Richard W P
authors.initials: RW
authors.lastname: Smith
authors.forename: Nicola K
authors.initials: NK
authors.lastname: Gray