title: Non-Helicobacter pylori gastritis is common among paediatric patients with inflammatory bowel disease.
abstract: BACKGROUND
  Helicobacter-negative gastritis and duodenitis occur more often in patients with inflammatory bowel disease (IBD) than in non-IBD controls. Preliminary evidence suggests that they are particularly common among children.
  
  
  OBJECTIVE
  To study the age-specific occurrence of gastritis and duodenitis among paediatric IBD patients.
  
  
  METHODS
  From a computerised database of surgical pathology reports, we selected 344 IBD patients and 4241 non-IBD controls between the age 0 and 21 years, who underwent colonoscopy and oesophago-gastro-duodenoscopy with biopsy results from both procedures.
  
  
  RESULTS
  Helicobacter-negative chronic active gastritis was found in 2% of controls and 20% of IBD patients (Crohn's disease (CD) 26%, ulcerative colitis (UC) 13%). Duodenitis was found in 2% of controls and 17% of IBD patients (Crohn's disease 28%, UC 8%). Similar prevalence rates were observed in male and female patients. The most striking age-specific patterns were seen in Crohn's disease, with chronic active gastritis being highest in the 5-9 years age-group and declining in all subsequent age-groups. The age-specific rise and fall of duodenitis appeared more protracted, reaching a peak at age 10-14 years and then gradually declining.
  
  
  CONCLUSIONS
  Helicobacter-negative gastritis and duodenitis occur significantly more often in paediatric IBD patients than in non-IBD controls, as well as in adult IBD patients. Such upper gastrointestinal inflammation appears to be particularly common in patients with Crohn's disease.
authors.affiliation: Miraca Life Sciences, Irving, TX, USA.
authors.forename: R M
authors.initials: RM
authors.lastname: Genta
authors.forename: A
authors.initials: A
authors.lastname: Sonnenberg
mesh_terms: D000293:Adolescent; D000367:Age Factors; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003424:Crohn Disease / Q000150:complications; D004382:Duodenitis / Q000209:etiology*; D005260:Female; D005756:Gastritis / Q000209:etiology* / Q000382:microbiology; D016481:Helicobacter Infections / Q000209:etiology* / Q000382:microbiology; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D007223:Infant; D015212:Inflammatory Bowel Diseases / Q000150:complications*; D008297:Male; D055815:Young Adult