title: Directing lung endoderm differentiation in pluripotent stem cells.
abstract: The lung is composed of numerous epithelial lineages that arise from the anterior foregut endoderm. This review discusses how insights into the signaling mechanisms that regulate lung endoderm specification and subsequent differentiation have recently been exploited to direct differentiation of hESCs/iPSCs into expandable lung progenitors.
authors.affiliation: Department of Cell and Developmental Biology, University of Pennsylvania, Philadelphia, 19104, USA.
authors.forename: Rachel S
authors.initials: RS
authors.lastname: Kadzik
authors.forename: Edward E
authors.initials: EE
authors.lastname: Morrisey
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D004707:Endoderm / Q000166:cytology / Q000196:embryology*; D006801:Humans; D008168:Lung / Q000166:cytology / Q000196:embryology*; D039904:Pluripotent Stem Cells / Q000166:cytology / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*