title: Syndrome of inappropriate antidiuretic hormone secretion in a patient with large cell neuroendocrine carcinoma.
abstract: The syndrome of inappropriate antidiuretic hormone secretion has only been reported in a few patients with large cell neuroendocrine carcinoma (LCNEC); however, it has never been reported in a patient with LCNEC of the lung, whose serum sodium levels were normalized after surgical resection of the mass. A 63-year-old male presented with a two-day history of dizziness and recent memory loss. On admission, his serum sodium level was 113 mEq/L with a serum osmolality of 236 mosm/kg, a urine osmolality of 441 mosm/kg, and a urine sodium level of 65 mEq/L. His chest computed tomography revealed a 2.7×2.3 cm-sized mass in the left lower lobe. After surgical removal of the mass, his serum sodium concentrations were normalized, and histopathology of the mass revealed LCNEC.
authors.affiliation: Department of Internal Medicine, Division of Nephrology, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Korea.
authors.forename: Hyung Jung
authors.initials: HJ
authors.lastname: Oh
authors.forename: Mi Jung
authors.initials: MJ
authors.lastname: Lee
authors.forename: Seon Jung
authors.initials: SJ
authors.lastname: Jang
authors.forename: Dong Ho
authors.initials: DH
authors.lastname: Shin
authors.forename: Shin-Wook
authors.initials: SW
authors.lastname: Kang
mesh_terms: D018287:Carcinoma, Large Cell / Q000473:pathology*; D018278:Carcinoma, Neuroendocrine / Q000473:pathology*; D006801:Humans; D007177:Inappropriate ADH Syndrome / Q000473:pathology*; D008297:Male; D008875:Middle Aged