title: Correlation of anti-Pru p 3 IgE levels with severity of peach allergy reactions in children.
abstract: BACKGROUND
  Peach allergy is regarded as one of the most important fresh fruit allergies. Data are available on the state-of-the-art diagnosis, including food challenges, and a component-resolved diagnosis. However, the roles played by different peach allergens with respect to symptom severity are not completely understood.
  
  
  OBJECTIVE
  To evaluate the role of serum specific IgE to peach and recombinant allergens in the diagnosis of peach allergies in Italian children.
  
  
  METHODS
  Forty-four children with peach allergy confirmed by a placebo-controlled food challenge were divided into 2 groups based on their symptom severity: patients with mild oral allergy syndrome (OAS) and patients with systemic symptoms (SS). The presence of specific IgE to peach and rPru p 1, rPru p 3, and rPru p 4 was determined.
  
  
  RESULTS
  The presence of specific IgE to Pru p 4 and Pru p 1 was found significantly more frequently in patients with OAS, whereas specific IgE to Pru p 3 was not found significantly more frequently in patients with SS. Only anti-rPru p 4 IgE levels were significantly higher in patients with OAS, whereas no significant differences were found in anti-rPru p 1 and anti-rPru p 3 IgE levels between patients with OAS compared with patients with SS.
  
  
  CONCLUSIONS
  In Italian children with peach allergies, the presence of specific IgE to Pru p 3 is not associated with SS, and the levels of specific IgE to Pru p 3 do not correlate with the severity of the reactions.
authors.affiliation: Allergy Unit, A. Meyer Children's Hospital, Department of Pediatrics, University of Florence, Florence, Italy.
authors.forename: Elio
authors.initials: E
authors.lastname: Novembre
authors.forename: Francesca
authors.initials: F
authors.lastname: Mori
authors.forename: Simona
authors.initials: S
authors.lastname: Contestabile
authors.forename: Maria Elisabetta
authors.initials: ME
authors.lastname: Rossi
authors.forename: Neri
authors.initials: N
authors.lastname: Pucci
mesh_terms: D000284:Administration, Oral; D000485:Allergens / Q000009:adverse effects / Q000276:immunology*; D052179:Antigens, Plant / Q000009:adverse effects / Q000276:immunology*; D002352:Carrier Proteins / Q000009:adverse effects / Q000276:immunology; D002648:Child; D018450:Disease Progression; D005260:Female; D005512:Food Hypersensitivity / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology* / Q000503:physiopathology*; D006801:Humans; D007114:Immunization; D007073:Immunoglobulin E / Q000097:blood*; D007558:Italy / Q000453:epidemiology; D008297:Male; D010940:Plant Proteins / Q000009:adverse effects / Q000276:immunology; D027861:Prunus / Q000009:adverse effects*; D011994:Recombinant Proteins / Q000009:adverse effects / Q000276:immunology
chemical_list: D000485:Allergens; D052179:Antigens, Plant; D002352:Carrier Proteins; D010940:Plant Proteins; C403252:Pru p 1 allergen; C463181:Pru p 3 allergen; C572509:Pru p 4 allergen, Prunus persica; D011994:Recombinant Proteins; D007073:Immunoglobulin E