title: Drug-loaded PLGA nanoparticles for oral administration: fundamental issues and challenges ahead.
abstract: Drug-loaded polylactide-co-glycolide (PLGA) nanoparticles have been extensively studied and have a practical impact on drug delivery. Many PLGA-based nanoformulations have reached different stages of preclinical development; however, they present distinct challenges for researchers. This review discusses some of the challenges and issues involved in selecting drug and polymer combinations for encapsulation, aggregation of nanoparticles during characterization in in vitro studies, sterilization, and long-term stability of drug-loaded nanoparticles. We include recommendations to overcome these challenges.
authors.affiliation: Department of Pharmacology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India.
authors.forename: Gaurav
authors.initials: G
authors.lastname: Kumar
authors.forename: Nusrat
authors.initials: N
authors.lastname: Shafiq
authors.forename: Samir
authors.initials: S
authors.lastname: Malhotra
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002626:Chemistry, Pharmaceutical; D004337:Drug Carriers; D004339:Drug Compounding; D006801:Humans; D019344:Lactic Acid / Q000737:chemistry*; D053758:Nanoparticles; D036103:Nanotechnology; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D013678:Technology, Pharmaceutical / Q000379:methods
chemical_list: D004337:Drug Carriers; D004364:Pharmaceutical Preparations; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid