title: Chemical and antiviral study on alkaloids from Papaver pseudocanescens M. Pop.
abstract: The phytochemical investigation of the aerial parts of Papaver pseudocanescens M. Pop. of Mongolian origin resulted in the isolation and structural elucidation of 8 alkaloids of the isoquinoline and promorphinane type. 8,14-Dihydroamurine, 8,14-dihydroflavinantine, and flavinantine are promorphinanes. Alborine, mecambridine, and mecambridine methohydroxide are retroprotoberberines. Amurensinine is an isopavine alkaloid and O-methylarmepavine is a benzylisoquinoline alkaloid. O-Methylarmepavine is a new alkaloid for the genus Papaver. Promorphinane-type alkaloids have been found for the first time in the species. All structures were established by physical and spectral analysis. As a first attempt to describe some of the biological activities of these alkaloids, the antiviral effect was tested against the in vitro replication of several viruses which belong to different taxonomic groups and represent significant human pathogens. Based on the results, the conclusion could be drawn that particular alkaloids from P. pseudocanescens possess selective antiviral effects against the replication of poliovirus 1 and human rhinovirus 14, two viruses from the Enterovirus genus of the Picornaviridae family.
authors.affiliation: Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., bl. 9, Sofia 1113, Bulgaria.
authors.forename: Ralitsa
authors.initials: R
authors.lastname: Istatkova
authors.forename: Lubomira
authors.initials: L
authors.lastname: Nikolaeva-Glomb
authors.forename: Angel
authors.initials: A
authors.lastname: Galabov
authors.forename: Gerelt-Od
authors.initials: GO
authors.lastname: Yadamsuren
authors.forename: Javzan
authors.initials: J
authors.lastname: Samdan
authors.forename: Selenge
authors.initials: S
authors.lastname: Dangaa
authors.forename: Stefan
authors.initials: S
authors.lastname: Philipov
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010207:Papaver / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000470:Alkaloids; D000998:Antiviral Agents