title: Twists and turns of invasion.
abstract: The transcription factor Twist1 is overexpressed in tumours and can induce the epithelial-mesenchymal transition, resulting in increased invasiveness. Twist1 is now shown to regulate cancer cell migration and invasion in three-dimensional environments by activating the RAC1 GTPase through suppression of a let-7 microRNA family member.
authors.forename: Geoffrey
authors.initials: G
authors.lastname: Childs
authors.forename: Jeffrey E
authors.initials: JE
authors.lastname: Segall
mesh_terms: D002465:Cell Movement; D006801:Humans; D009369:Neoplasms / Q000378:metabolism* / Q000473:pathology*; D009687:Nuclear Proteins / Q000378:metabolism*; D051879:Twist-Related Protein 1 / Q000378:metabolism*; D020830:rac1 GTP-Binding Protein / Q000378:metabolism*
chemical_list: D009687:Nuclear Proteins; C107953:RAC1 protein, human; C103173:TWIST1 protein, human; D051879:Twist-Related Protein 1; D020830:rac1 GTP-Binding Protein