title: Allogeneic hematopoietic stem cell transplant for adults over 40 years old with acquired aplastic anemia.
abstract: Although younger age is associated with favorable prognosis in adults undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT) for aplastic anemia (AA), other pretransplantation factors may be more important than age. We retrospectively analyzed the impact of older age on transplantation outcomes and survival in a total of 225 adult patients with AA who underwent allo-HSCT: 57 patients >40 years old (older patient group [OPG]) and 168 patients ≤40 years old (younger patient group [YPG]). Age at allo-HSCT ≤40 years, time from diagnosis to allo-HSCT ≤6 months, and matched related donor (MRD) were favorable prognostic factors in all study patients. Risk analysis of survival in the OPG showed that age >50 years was the only poor prognostic factor. Survival did not differ significantly between the YPG and patients <50 years old in the OPG. In conclusion, patients between the ages of 41 and 50 years with severe AA and MRDs should undergo allo-HSCT as early as possible to optimize survival.
authors.affiliation: Ulsan University Hospital, Korea.
authors.forename: Hawk
authors.initials: H
authors.lastname: Kim
authors.forename: Kyoo-Hyung
authors.initials: KH
authors.lastname: Lee
authors.forename: Sung-Soo
authors.initials: SS
authors.lastname: Yoon
authors.forename: Sang Kyun
authors.initials: SK
authors.lastname: Sohn
authors.forename: Young Don
authors.initials: YD
authors.lastname: Joo
authors.forename: Sung Hyun
authors.initials: SH
authors.lastname: Kim
authors.forename: Byung Soo
authors.initials: BS
authors.lastname: Kim
authors.forename: Jung Hye
authors.initials: JH
authors.lastname: Choi
authors.forename: Jae Youg
authors.initials: JY
authors.lastname: Kwak
authors.forename: Myung Soo
authors.initials: MS
authors.lastname: Hyun
authors.forename: Sung Hwa
authors.initials: SH
authors.lastname: Bae
authors.forename: Ho Jin
authors.initials: HJ
authors.lastname: Shin
authors.forename: Jong Ho
authors.initials: JH
authors.lastname: Won
authors.forename: Sukjoong
authors.initials: S
authors.lastname: Oh
authors.forename: Won Sik
authors.initials: WS
authors.lastname: Lee
authors.forename: Jae-Hoo
authors.initials: JH
authors.lastname: Park
authors.forename: Chul Won
authors.initials: CW
authors.lastname: Jung
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000741:Anemia, Aplastic / Q000276:immunology / Q000401:mortality / Q000628:therapy*; D018572:Disease-Free Survival; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006648:Histocompatibility; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors; D014019:Tissue Donors; D014184:Transplantation, Homologous; D016896:Treatment Outcome