title: (1)H, (13)C, (15)N backbone and side-chain resonance assignments of rat angiogenin.
abstract: Angiogenin is an unusual member of the pancreatic ribonuclease superfamily that induces formation of new blood vessels and is a promising anti-cancer target. Here we report backbone and side chain (1)H, (13)C, and (15)N resonance assignments for rat angiogenin (residues 24-145), excluding the N-terminal signal peptide. These data allow nuclear magnetic resonance structure and inhibitor-binding studies with the aim of providing angiogenin antagonists as potential therapeutics.
authors.affiliation: Division of Magnetic Resonance, Korea Basic Science Institute, 162 Yeongudanji-Ro, Ochang, Cheongwon, Chungbuk, 363-883, Korea.
authors.forename: Chung-Kyung
authors.initials: CK
authors.lastname: Lee
authors.forename: Kwon Joo
authors.initials: KJ
authors.lastname: Yeo
authors.forename: Eunha
authors.initials: E
authors.lastname: Hwang
authors.forename: Hae-Kap
authors.initials: HK
authors.lastname: Cheong
mesh_terms: D000818:Animals; D019906:Nuclear Magnetic Resonance, Biomolecular; D051381:Rats; D012259:Ribonuclease, Pancreatic / Q000737:chemistry*; D012996:Solutions
chemical_list: D012996:Solutions; C046366:angiogenin; D012259:Ribonuclease, Pancreatic