title: Best predictors of survival outcome after tertiary cytoreduction in patients with recurrent platinum-sensitive epithelial ovarian cancer.
abstract: OBJECTIVE
  To evaluate the efficacy of tertiary cytoreduction (TCR) on survival and to determine prognostic factors which may influence surgical and survival outcome.
  
  
  METHODS
  Twenty-three consecutive patients who had recurrent platinum-sensitive epithelial ovarian cancer and underwent TCR between January 1999 and January 2011 were evaluated. Factors which impact on TCR outcome and survival were determined by statistical analysis.
  
  
  RESULTS
  TCR was optimal (< 1cm residual tumor) in 15 of the 23 patients (65.2%) and suboptimal in 8 patients (34.8%). None of the clinicopathologic factors was associated with TCR outcome. On the contrary, TCR outcome (optimal vs suboptimal) was independently associated with survival in univariate analysis (P=0.018).
  
  
  CONCLUSIONS
  There is not a good predictor of TCR outcome but TCR seems to be beneficial for patients in whom optimal surgery can be achieved. Therefore, preoperative assessment of patients and weighing the potential survival benefit against potential surgical risks are very important for patient selection.
authors.affiliation: Etlik Zübeyde Hanım Women's Health Teaching and Research Hospital, Department of Gynecologic Oncology, Ankara, Turkey. denizhizli@yahoo.com
authors.forename: Deniz
authors.initials: D
authors.lastname: Hızlı
authors.forename: Nurettin
authors.initials: N
authors.lastname: Boran
authors.forename: Saynur
authors.initials: S
authors.lastname: Yılmaz
authors.forename: Taner
authors.initials: T
authors.lastname: Turan
authors.forename: Sadıman Kıykaç
authors.initials: SK
authors.lastname: Altınbaş
authors.forename: Bülent
authors.initials: B
authors.lastname: Celik
authors.forename: M Faruk
authors.initials: MF
authors.lastname: Köse
mesh_terms: D000328:Adult; D000368:Aged; D000077216:Carcinoma, Ovarian Epithelial; D005260:Female; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality* / Q000601:surgery; D018365:Neoplasm, Residual; D009375:Neoplasms, Glandular and Epithelial / Q000401:mortality / Q000601:surgery*; D010051:Ovarian Neoplasms / Q000401:mortality / Q000601:surgery*; D010984:Platinum / Q000627:therapeutic use*; D011379:Prognosis; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D010984:Platinum