title: Tick-borne diseases in cattle: applications of proteomics to develop new generation vaccines.
abstract: Tick-borne diseases (TBDs) affect 80% of the world's cattle population, hampering livestock production throughout the world. Livestock industry is important to rural populations not only as food supply, but also as a source of income. Tick control is usually achieved by using acaricides which are expensive, deleterious to the environment and can induce chemical resistance of vectors; the development of more effective and sustainable control methods is therefore required. Theileriosis, babesiosis, anaplasmosis and heartwater are the most important TBDs in cattle. Immunization strategies are currently available but with variable efficacy. To develop a new generation of vaccines which are more efficient, cheaper and safer, it is first necessary to better understand the mechanisms by which these parasites are transmitted, multiply and cause disease; this becomes especially difficult due to their complex life cycles, in vitro culture conditions and the lack of genetic tools to manipulate them. Proteomics and other complementary post-genomic tools such as transcriptomics and metabolomics in a systems biology context are becoming key tools to increase knowledge on the biology of infectious diseases. Herein, we present an overview of the so called "Omics" studies currently available on these tick-borne pathogens, giving emphasis to proteomics and how it may help to discover new vaccine candidates to control TBDs.
authors.affiliation: IBET, Apartado 12, 2780-901 Oeiras, Portugal. marcelino@itqb.unl.pt
authors.forename: Isabel
authors.initials: I
authors.lastname: Marcelino
authors.forename: André Martinho
authors.initials: AM
authors.lastname: de Almeida
authors.forename: Miguel
authors.initials: M
authors.lastname: Ventosa
authors.forename: Ludovic
authors.initials: L
authors.lastname: Pruneau
authors.forename: Damien F
authors.initials: DF
authors.lastname: Meyer
authors.forename: Dominique
authors.initials: D
authors.lastname: Martinez
authors.forename: Thierry
authors.initials: T
authors.lastname: Lefrançois
authors.forename: Nathalie
authors.initials: N
authors.lastname: Vachiéry
authors.forename: Ana Varela
authors.initials: AV
authors.lastname: Coelho
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000378:metabolism* / Q000517:prevention & control*; D016503:Drug Delivery Systems / Q000662:veterinary*; D020543:Proteome / Q000378:metabolism*; D040901:Proteomics / Q000379:methods*; D016052:Protozoan Vaccines / Q000627:therapeutic use*; D013981:Tic Disorders / Q000378:metabolism / Q000517:prevention & control / Q000662:veterinary*
chemical_list: D020543:Proteome; D016052:Protozoan Vaccines