title: Association between recurrent metastasis from stage II and III primary colorectal tumors and moderate microsatellite instability.
abstract: Colorectal cancer cells frequently have low levels of microsatellite instability (MSI-L) and elevated microsatellite alterations at selected tetranucleotide repeats (EMAST), but little is known about the clinicopathologic significance of these features. We observed that patients with stage II or III colorectal cancer with MSI-L and/or EMAST had shorter times of recurrence-free survival than patients with high levels of MSI (P = .0084) or with highly stable microsatellites P = .0415), based on Kaplan-Meier analysis. MSI-L and/or EMAST were independent predictors of recurrent distant metastasis from primary stage II or III colorectal tumors (Cox proportional hazard analysis: hazard ratio, 1.83; 95% confidence interval, 1.06-3.15; P = .0301).
authors.affiliation: Gastrointestinal Cancer Research Laboratory, Baylor University Medical Center, Dallas, Texas 75246, USA.
authors.forename: Melissa
authors.initials: M
authors.lastname: Garcia
authors.forename: Chan
authors.initials: C
authors.lastname: Choi
authors.forename: Hyeong-Rok
authors.initials: HR
authors.lastname: Kim
authors.forename: Yahya
authors.initials: Y
authors.lastname: Daoud
authors.forename: Yuji
authors.initials: Y
authors.lastname: Toiyama
authors.forename: Masanobu
authors.initials: M
authors.lastname: Takahashi
authors.forename: Ajay
authors.initials: A
authors.lastname: Goel
authors.forename: C Richard
authors.initials: CR
authors.lastname: Boland
authors.forename: Minoru
authors.initials: M
authors.lastname: Koi
mesh_terms: D015179:Colorectal Neoplasms / Q000235:genetics* / Q000473:pathology*; D006801:Humans; D053208:Kaplan-Meier Estimate; D053842:Microsatellite Instability; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000235:genetics*