title: Perinatal characteristics and risk of polio among Swedish twins.
abstract: Prenatal exposure to adverse environmental conditions is related to increased adult mortality in regions where infections are highly prevalent, yet there is little evidence of the impact of perinatal conditions on the risk of severe infections throughout life. Using prospectively collected data from 21 604 like-sexed Swedish twins of known zygosity born in 1926-1958, we examined the risk of polio in relation to perinatal characteristics using cohort and nested co-twin case-control analyses. Polio incidence was determined through an interview in 1998, and linkage with the Swedish national inpatient and death registries. There were 133 cases of polio. In the cohort analysis, birth length, birthweight and head circumference were positively associated with polio risk. After adjustment for sex, birth year, gestational age at birth and within-twin pair correlations, twins of shortest length (<44 cm) had a 67% ([95% CI: 6%, 88%]; P=0.04) lower risk of polio compared with the reference group (47-49 cm). After additional adjustment for birth length, every 100-g increase in birthweight was related to a 34% increased risk of polio ([95% CI: -1%, 82%]; P=0.06), and every 10-mm increase in head circumference was related to a 17% greater risk of polio ([95% CI: 5%, 31%]; P=0.004). In co-twin control analyses among 226 disease-discordant twins, birth length, birthweight and head circumference were 0.3 cm (P=0.19), 84 g (P=0.07) and 3 mm (P=0.08) higher in cases than controls, respectively. Similar associations were observed among monozygotic (n=84) and dizygotic (n=142) twins. These findings suggest that early intrauterine growth restriction may be inversely related to the incidence of polio.
authors.affiliation: Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA. perngwei@umich.edu
authors.forename: Wei
authors.initials: W
authors.lastname: Perng
authors.forename: Sven
authors.initials: S
authors.lastname: Cnattingius
authors.forename: Anastasia
authors.initials: A
authors.lastname: Iliadou
authors.forename: Eduardo
authors.initials: E
authors.lastname: Villamor
mesh_terms: D001724:Birth Weight; D004200:Diseases in Twins / Q000453:epidemiology*; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D008297:Male; D008423:Maternal Age; D011051:Poliomyelitis / Q000453:epidemiology*; D012307:Risk Factors; D012959:Socioeconomic Factors; D013548:Sweden / Q000453:epidemiology; D014427:Twins / Q000706:statistics & numerical data*