title: Complete valvular heart apparatus model from 4D cardiac CT.
abstract: The cardiac valvular apparatus, composed of the aortic, mitral, pulmonary and tricuspid valves, is an essential part of the anatomical, functional and hemodynamic characteristics of the heart and the cardiovascular system as a whole. Valvular heart diseases often involve multiple dysfunctions and require joint assessment and therapy of the valves. In this paper, we propose a complete and modular patient-specific model of the cardiac valvular apparatus estimated from 4D cardiac CT data. A new constrained Multi-linear Shape Model (cMSM), conditioned by anatomical measurements, is introduced to represent the complex spatio-temporal variation of the heart valves. The cMSM is exploited within a learning-based framework to efficiently estimate the patient-specific valve parameters from cine images. Experiments on 64 4D cardiac CT studies demonstrate the performance and clinical potential of the proposed method. Our method enables automatic quantitative evaluation of the complete valvular apparatus based on non-invasive imaging techniques. In conjunction with existent patient-specific chamber models, the presented valvular model enables personalized computation modeling and realistic simulation of the entire cardiac system.
authors.affiliation: Image Analytics and Medical Informatics, Siemens Corporate Research, Princeton, New Jersey 08540, USA. sasa.grbic@siemens.com
authors.forename: Sasa
authors.initials: S
authors.lastname: Grbic
authors.forename: Razvan
authors.initials: R
authors.lastname: Ionasec
authors.forename: Dime
authors.initials: D
authors.lastname: Vitanovski
authors.forename: Ingmar
authors.initials: I
authors.lastname: Voigt
authors.forename: Yang
authors.initials: Y
authors.lastname: Wang
authors.forename: Bogdan
authors.initials: B
authors.lastname: Georgescu
authors.forename: Nassir
authors.initials: N
authors.lastname: Navab
authors.forename: Dorin
authors.initials: D
authors.lastname: Comaniciu
mesh_terms: D055424:Cardiac-Gated Imaging Techniques / Q000379:methods*; D017023:Coronary Angiography / Q000379:methods; D006349:Heart Valve Diseases / Q000000981:diagnostic imaging* / Q000473:pathology*; D006351:Heart Valves / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008953:Models, Anatomic; D008955:Models, Cardiovascular; D009068:Movement; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods*