title: Antiulcer potential of the ethanolic extract of Aerva persica Merrill root in rats.
abstract: The ethanol extract of the roots of Aerva persica (Burm f) Merrill (Amaranthaceae) was investigated to determine its antiulcer and in vivo antioxidant activities in albino Wistar rats. Ulcers were induced by ethanol and pylorus ligation. The extract was administered at the dose of 200mg/kg orally, p.o. for 15 consecutive days. The ulcer index of the ethanol extract was found to be significantly reduced compared with control animals. The effect was also assessed by determining the free acidity, pepsin activity, total carbohydrate (TC), and protein content (PK) in control, standard, and test group animals. The in vivo antioxidant activity was evaluated by determining the reduced glutathione level (GSH) and malondialdehyde (MDA) level in the tissue homogenates. The results reveal the significant reduction in the level of malondialdehyde and the increase in the level of reduced glutathione in the rats that received the ethanolic extract. Furthermore, histopathological studies have shown that pretreatment with the ethanolic extract of the roots of A persica reduces (100%) ethanol- and pylorus ligation-induced hemorrhagic necrosis in rats.
authors.affiliation: Department of Pharmaceutical Sciences, Guru Jambheshwar University of Science and Technology, Hisar, India. neeruvasudeva@gmail.com
authors.forename: Neeru
authors.initials: N
authors.lastname: Vasudeva
authors.forename: Payal
authors.initials: P
authors.lastname: Sethi
authors.forename: Surendra Kr
authors.initials: SK
authors.lastname: Sharma
authors.forename: Suresh
authors.initials: S
authors.lastname: Kumar
authors.forename: Sunil
authors.initials: S
authors.lastname: Sharma
mesh_terms: D000143:Acids / Q000032:analysis; D027703:Amaranthaceae; D000818:Animals; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D002241:Carbohydrates / Q000032:analysis; D000431:Ethanol; D005260:Female; D005750:Gastric Juice / Q000737:chemistry / Q000187:drug effects; D005978:Glutathione / Q000097:blood; D006470:Hemorrhage / Q000517:prevention & control; D006801:Humans; D008026:Ligation; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D009336:Necrosis / Q000517:prevention & control; D010434:Pepsin A / Q000378:metabolism; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D018517:Plant Roots; D011506:Proteins / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D012720:Severity of Illness Index; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology
chemical_list: D000143:Acids; D000897:Anti-Ulcer Agents; D000975:Antioxidants; D002241:Carbohydrates; D010936:Plant Extracts; D011506:Proteins; D000431:Ethanol; D008315:Malondialdehyde; D010434:Pepsin A; D005978:Glutathione