title: [The oncofetal gene survivin - a possible target gene for regenerative therapy concepts in cartilaginous tissue].
abstract: Survivin, the smallest member of the inhibitor of the apoptosis protein gene family (IAP) is a key molecule for mammalian cell cycle regulation and cellular survival. Of note these functions have been thought to be limited to embryonic and malignant tissues. However, a growing body of evidence indicates a limited expression of survivin in some highly specific adult tissues and cells. In the present study it has been demonstrated that the antiapoptotic protein survivin is re-expressed in osteoarthritic human cartilage and primary human chondrocytes. Furthermore, the data indicated that survivin significantly affects cell cycle regulation and cellular survival. The modulation of survivin expression and function in cartilaginous tissues might be important for understanding osteoarthritis and the development of regenerative strategies.
authors.affiliation: Orthopädische Klinik für die Universität Regensburg, Asklepios Klinikum, Kaiser-Karl-V.-Allee 3, 93077, Bad Abbach, Deutschland. phillechler@aol.co.uk
authors.forename: P
authors.initials: P
authors.lastname: Lechler
authors.forename: M
authors.initials: M
authors.lastname: Handel
authors.forename: S
authors.initials: S
authors.lastname: Anders
authors.forename: S
authors.initials: S
authors.lastname: Balakrishnan
authors.forename: J
authors.initials: J
authors.lastname: Grifka
mesh_terms: D000328:Adult; D000951:Antigens, Neoplasm / Q000235:genetics / Q000378:metabolism*; D018390:Gene Targeting / Q000379:methods*; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D051034:Inhibitor of Apoptosis Proteins / Q000378:metabolism*; D010003:Osteoarthritis / Q000235:genetics / Q000503:physiopathology / Q000628:therapy*; D012038:Regeneration / Q000502:physiology*; D000077022:Survivin
chemical_list: D000951:Antigens, Neoplasm; C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D000077022:Survivin; C031192:oncofetal antigens