title: Repetitive exposure to a 7 Tesla static magnetic field of mice in utero does not cause alterations in basal emotional and cognitive behavior in adulthood.
abstract: In the past three decades, magnetic resonance imaging (MRI) has been increasingly used in obstetrics to aid diagnostics of maternal and fetal conditions and has generally been considered a safe imaging method. However, the development of higher-performance systems employing, for example, stronger fields to improve the technique's diagnostic potential, necessitates on-going safety evaluation. Rodent studies provide an excellent opportunity to investigate not only acute but also long-term effects of magnetic field exposure in a systematic manner, and a behavioral analysis might help to uncover subtler effects which might result from magnetic field exposure of the vulnerable developing brain. We conducted a comprehensive investigation of emotional and cognitive behavior in adult mice which had been repeatedly exposed to a 7 Tesla static magnetic field in utero. Using well-validated tests, we did not observe any adverse behavioral alterations regarding emotional behavior as well as spatial and emotional learning.
authors.affiliation: Research Group Animal Models in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Germany. carolin.hoyer@zi-mannheim.de
authors.forename: Carolin
authors.initials: C
authors.lastname: Hoyer
authors.forename: Miriam A
authors.initials: MA
authors.lastname: Vogt
authors.forename: S Helene
authors.initials: SH
authors.lastname: Richter
authors.forename: Gregor
authors.initials: G
authors.lastname: Zaun
authors.forename: Yasmin
authors.initials: Y
authors.lastname: Zahedi
authors.forename: Stefan
authors.initials: S
authors.lastname: Maderwald
authors.forename: Mark E
authors.initials: ME
authors.lastname: Ladd
authors.forename: Elke
authors.initials: E
authors.lastname: Winterhager
authors.forename: Ruth
authors.initials: R
authors.lastname: Grümmer
authors.forename: Peter
authors.initials: P
authors.lastname: Gass
mesh_terms: D000818:Animals; D001362:Avoidance Learning; D001522:Behavior, Animal; D003071:Cognition; D004644:Emotions; D005260:Female; D060526:Magnetic Fields; D008279:Magnetic Resonance Imaging; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011247:Pregnancy