title: Cefazolin-induced neutropenia and thrombocytopenia following trauma: a case report.
abstract: Cefazolin, a first generation cephalosporin, is a rare cause of cyclical fevers, neutropenia, and thrombocytopenia following surgical prophylaxis. We present the case of an otherwise healthy 21-year-old male who sustained a 50-cm laceration to his chest and abdomen. He received emergency department prophylaxis with cefazolin and surgical repair. Subsequently, he developed cyclical fevers, neutropenia, and thrombocytopenia, all of which resolved after antibiotic discontinuation. This is the first case report in which the perioperative administration of cefazolin following trauma resulted in significant neutropenia and thrombocytopenia. Also discussed in this report are the etiology, workup, and treatment of cefazolin-induced neutropenia.
authors.affiliation: Department of Surgery, Madigan Army Medical Center, 9040 Jackson Avenue, Tacoma, WA 98431, USA.
authors.forename: Avery S
authors.initials: AS
authors.lastname: Walker
authors.forename: Marlin W
authors.initials: MW
authors.lastname: Causey
authors.forename: James A
authors.initials: JA
authors.lastname: Sebesta
mesh_terms: D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D019072:Antibiotic Prophylaxis; D002437:Cefazolin / Q000009:adverse effects*; D006801:Humans; D022125:Lacerations / Q000601:surgery*; D008297:Male; D009503:Neutropenia / Q000139:chemically induced*; D013530:Surgical Wound Infection / Q000517:prevention & control*; D035441:Thoracic Wall / Q000293:injuries*; D013921:Thrombocytopenia / Q000139:chemically induced*; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D002437:Cefazolin