title: Mucosa-associated lymphoid tissue lymphoma of the trachea: case report.
abstract: BACKGROUND
  Mucosa-associated lymphoid tissue (MALT) lymphomas are most commonly found in the stomach, lungs, orbital soft tissue, salivary glands and thyroid. Involvement of the trachea is extremely rare.
  
  
  METHODS
  This report describes a rare case of MALT lymphoma of the trachea in a 71-year-old woman who presented with a one-year history of coughing, dyspnea, hoarseness and weight loss. There was an infiltrative lesion in the mid-trachea. The anatomopathological diagnosis was only made from the fifth endoscopic biopsy attempt. Immunochemotherapy consisting of rituximab, cyclophosphamide, vincristine and prednisone (R-COP) induced complete remission of the symptoms and endoscopic lesion.
  
  
  CONCLUSIONS
  MALT lymphoma of the trachea is extremely rare and indolent disease. It has to be considered in the differential diagnosis of airway lesions. It is crucial to obtain an anatomopathological diagnosis from a specialized pathologist. Immunochemotherapy with R-COP induced complete remission of the disease.
authors.affiliation: Discipline of Internal Medicine, Department of Clinical Medicine, Faculdade de Ciências Médicas, Santa Casa de São Paulo, Brazil. elisamagliari@hotmail.com
authors.forename: Maria Elisa Ruffolo
authors.initials: ME
authors.lastname: Magliari
authors.forename: Renata Telles Rudge de
authors.initials: RT
authors.lastname: Aquino
authors.forename: Anna Luiza Lobão
authors.initials: AL
authors.lastname: Gonçalves
authors.forename: Fábio
authors.initials: F
authors.lastname: Marioni
authors.forename: Fabíola del Carlo
authors.initials: Fdel C
authors.lastname: Bernardi
authors.forename: Sérgio
authors.initials: S
authors.lastname: Brasil
authors.forename: Joaquim Antonio da Fonseca
authors.initials: JA
authors.lastname: Almeida
authors.forename: Benedito Juarez
authors.initials: BJ
authors.lastname: Andrade
authors.forename: Carlos Sérgio
authors.initials: CS
authors.lastname: Chiattone
authors.forename: Carlos Alberto da Conceição
authors.initials: CA
authors.lastname: Lima
mesh_terms: D000368:Aged; D058846:Antibodies, Monoclonal, Murine-Derived / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000008:administration & dosage; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000188:drug therapy / Q000473:pathology*; D011241:Prednisone / Q000008:administration & dosage; D012074:Remission Induction; D000069283:Rituximab; D014134:Tracheal Neoplasms / Q000188:drug therapy / Q000473:pathology*; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D058846:Antibodies, Monoclonal, Murine-Derived; D000970:Antineoplastic Agents; D000069283:Rituximab; D014750:Vincristine; D003520:Cyclophosphamide; D011241:Prednisone