title: Reductive N-alkylation of nitroarenes: a green approach for the N-alkylation of natural products.
abstract: A simple, mild, cost-effective, and green approach for the reductive mono-N-alkylation of nitroarenes has been developed. HOAc/Zn are utilized as the reducing system together with a carbonyl compound as an alkyl source in methanol. Excellent yields were obtained with stoichiometric control of mono- over dialkylated products. Application to five complex natural products demonstrated the practical utility of the method.
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, The University of Mississippi, University, Mississippi 38677, United States.
authors.forename: Amir E
authors.initials: AE
authors.lastname: Wahba
authors.forename: Mark T
authors.initials: MT
authors.lastname: Hamann
mesh_terms: D000478:Alkylation; D001688:Biological Products / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D009574:Nitro Compounds / Q000737:chemistry*
chemical_list: D001688:Biological Products; D009574:Nitro Compounds