title: Patient-specific respiratory models using dynamic 3D MRI: preliminary volunteer results.
abstract: Organ and tumour motion has a significant impact on the planning and delivery of radiotherapy treatment. At present imaging modality such as four-dimensional computer tomography (4DCT) cannot be used to measure the variability of motion between different respiratory cycles. To create reliable motion models, one needs to acquire volumetric data sets of the lungs with sufficient sampling of the breathing cycle. In this paper we investigate the use of highly parallel MRI to acquire such data. A 32 channel coil in conjunction with a balanced SSFP sequence and a SENSE factor of 6 were used to acquire volumetric data sets in five healthy volunteers. The acquisition was repeated for seven series of different breathing patterns. The data acquired was of sufficient spatial resolution (5 × 5 × 5 mm(3)) and image quality to carry out automated non-rigid registration. The acquisition rate (c.a. 2 volumes per second) allowed for a meaningful sampling of the different respiratory curves that were automatically obtained from the skin surface motion. This acquisition technique should provide images of high enough quality to create statistical respiratory models.
authors.affiliation: Clinical Physics, Barts and the London NHS Trust, London, UK. m.e.miquel@qmul.ac.uk
authors.forename: M E
authors.initials: ME
authors.lastname: Miquel
authors.forename: J M
authors.initials: JM
authors.lastname: Blackall
authors.forename: S
authors.initials: S
authors.lastname: Uribe
authors.forename: D J
authors.initials: DJ
authors.lastname: Hawkes
authors.forename: T
authors.initials: T
authors.lastname: Schaeffter
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008297:Male; D008954:Models, Biological; D009068:Movement; D057285:Precision Medicine; D012119:Respiration; D013909:Thorax / Q000502:physiology; D013997:Time Factors