title: Comparison of the efficacy of alpha-lactalbumin from equine, bovine, and human milk in the growth of intestinal IEC-6 cells.
abstract: Native alpha-lactalbumins (α-LA) from equine, bovine, and human milk were not cytotoxic. However, after treatment with trifluoroethanol (TFE), all three α-LAs exhibited cytotoxicity. Toxic potencies were distinctly different among them. Equine α-LA was the most robust, bovine α-LA was moderate, and human α-LA was weak. There were no significant structural changes as between the native and the TFE-treated α-LAs.
authors.affiliation: United Graduate School of Agricultural Science, Gifu University, Gifu, Japan.
authors.lastname: Xijier
authors.forename: Yuki
authors.initials: Y
authors.lastname: Mori
authors.forename: Mayuko
authors.initials: M
authors.lastname: Fukuoka
authors.lastname: Cairangzhuoma
authors.forename: Mizuho
authors.initials: M
authors.lastname: Inagaki
authors.forename: Satoshi
authors.initials: S
authors.lastname: Iwamoto
authors.forename: Tomio
authors.initials: T
authors.lastname: Yabe
authors.forename: Yoshihiro
authors.initials: Y
authors.lastname: Kanamaru
mesh_terms: D000818:Animals; D002417:Cattle; D002460:Cell Line; D049109:Cell Proliferation / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002850:Chromatography, Gel; D003956:Dialysis; D004847:Epithelial Cells / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006736:Horses; D006801:Humans; D007422:Intestines / Q000166:cytology / Q000187:drug effects; D007768:Lactalbumin / Q000737:chemistry* / Q000494:pharmacology; D008892:Milk / Q000737:chemistry*; D008895:Milk, Human / Q000737:chemistry*; D011487:Protein Conformation; D051381:Rats; D014270:Trifluoroethanol / Q000737:chemistry / Q000633:toxicity*
chemical_list: D014270:Trifluoroethanol; D007768:Lactalbumin