title: Relation of bosentan, iloprost, and sildenafil with growth factor levels in monocrotaline-induced pulmonary hypertension.
abstract: It is believed that growth factors play an important role in vascular remodeling that is evident in pulmonary hypertension (PH) pathogenesis. In the present study, the vascular endothelial growth factor (VEGF) levels in serum and pulmonary artery samples of rats have been analyzed with monocrotaline (MCT)-induced PH after treatments with iloprost, bosentan, and sildenafil. Serum VEGF and pulmonary artery VEGF levels were found to be significantly lower in MCT groups compared with control groups and significantly higher in treatment groups compared with MCT groups. In conclusion, treatment strategies directed at increasing VEGF levels may be reasonable in PH management.
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Eskisehir Osmangazi University, Eskisehir, Turkey. scelebi@ogu.edu.tr
authors.forename: Semra
authors.initials: S
authors.lastname: Yigitaslan
authors.forename: Basar
authors.initials: B
authors.lastname: Sirmagul
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D000077300:Bosentan; D005260:Female; D006976:Hypertension, Pulmonary / Q000097:blood* / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D016285:Iloprost / Q000627:therapeutic use*; D016686:Monocrotaline / Q000633:toxicity; D010879:Piperazines / Q000627:therapeutic use*; D011651:Pulmonary Artery / Q000378:metabolism; D011687:Purines / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D000068677:Sildenafil Citrate; D013449:Sulfonamides / Q000627:therapeutic use*; D013450:Sulfones / Q000627:therapeutic use*; D016212:Transforming Growth Factor beta / Q000097:blood / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A / Q000097:blood / Q000378:metabolism; D014665:Vasodilator Agents / Q000627:therapeutic use
chemical_list: D000959:Antihypertensive Agents; D010879:Piperazines; D011687:Purines; D013449:Sulfonamides; D013450:Sulfones; D016212:Transforming Growth Factor beta; D042461:Vascular Endothelial Growth Factor A; D014665:Vasodilator Agents; C467498:vascular endothelial growth factor A, rat; D016686:Monocrotaline; D000068677:Sildenafil Citrate; D016285:Iloprost; D000077300:Bosentan