title: Hemin/G-quadruplex simultaneously acts as NADH oxidase and HRP-mimicking DNAzyme for simple, sensitive pseudobienzyme electrochemical detection of thrombin.
abstract: For the first time, hemin/G-quadruplex was employed to simultaneously serve as NADH oxidase and an HRP-mimicking DNAzyme for constructing a simple and sensitive pseudobienzyme-amplifying electrochemical aptasensor for thrombin detection.
authors.affiliation: Key Laboratory on Luminescence and Real-Time Analysis, Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China.
authors.forename: Yali
authors.initials: Y
authors.lastname: Yuan
authors.forename: Ruo
authors.initials: R
authors.lastname: Yuan
authors.forename: Yaqin
authors.initials: Y
authors.lastname: Chai
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhuo
authors.forename: Xiaoya
authors.initials: X
authors.lastname: Ye
authors.forename: Xianxue
authors.initials: X
authors.lastname: Gan
authors.forename: Lijuan
authors.initials: L
authors.lastname: Bai
mesh_terms: D055162:Biocatalysis; D040761:Biomimetic Materials / Q000378:metabolism; D021881:DNA, Catalytic / Q000378:metabolism*; D055664:Electrochemical Techniques; D054856:G-Quadruplexes; D006427:Hemin / Q000737:chemistry*; D006735:Horseradish Peroxidase / Q000378:metabolism; D009097:Multienzyme Complexes / Q000378:metabolism; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism; D013917:Thrombin / Q000032:analysis*
chemical_list: D021881:DNA, Catalytic; D009097:Multienzyme Complexes; D006427:Hemin; D006735:Horseradish Peroxidase; C023107:NADH oxidase; D009247:NADH, NADPH Oxidoreductases; D013917:Thrombin