title: Polymer-based restoration of left ventricular mechanics.
abstract: Heart failure continues to be a major health care concern with relatively few options for severely advanced heart failure patients. The hallmark of heart failure is the progressive dilatation of the left ventricle, thinning of the left ventricular wall leading to increased wall stress and increased myocardial oxygen consumption. Applying Laplace's law to the failing dilated ventricle, left ventricular augmentation utilizes a tissue engineering strategy to increase wall thickness and reduce chamber diameter, resulting in a decrease in wall stress and improved left ventricular function. A review of the rationale for an in situ tissue engineering approach for this treatment of heart failure and early clinical results of the Algisyl-LVR™ program are presented.
authors.affiliation: Cardiovascular Research Institute, University of California-San Francisco, San Francisco, CA, USA. lee@medicine.ucsf.edu
authors.forename: Randall J
authors.initials: RJ
authors.lastname: Lee
authors.forename: Andy
authors.initials: A
authors.lastname: Hinson
authors.forename: Sam
authors.initials: S
authors.lastname: Helgerson
authors.forename: Robert
authors.initials: R
authors.lastname: Bauernschmitt
authors.forename: Hani N
authors.initials: HN
authors.lastname: Sabbah
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000464:Alginates / Q000737:chemistry; D002311:Cardiomyopathy, Dilated / Q000601:surgery / Q000628:therapy; D001026:Coronary Artery Bypass; D020723:Glucuronic Acid / Q000737:chemistry; D006333:Heart Failure / Q000628:therapy*; D006352:Heart Ventricles / Q000503:physiopathology*; D006603:Hexuronic Acids / Q000737:chemistry; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry / Q000627:therapeutic use; D008875:Middle Aged; D010865:Pilot Projects; D011108:Polymers / Q000737:chemistry* / Q000627:therapeutic use; D012720:Severity of Illness Index; D023822:Tissue Engineering; D016277:Ventricular Function, Left / Q000502:physiology*; D055815:Young Adult
chemical_list: D000464:Alginates; D006603:Hexuronic Acids; D011108:Polymers; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D020723:Glucuronic Acid