title: The APOL1 genotype of African American kidney transplant recipients does not impact 5-year allograft survival.
abstract: Apolipoprotein L-1 (APOL1) gene variants are associated with end-stage renal disease in African Americans (AAs). Here we investigate the impact of recipient APOL1 gene distributions on kidney allograft outcomes. We conducted a retrospective analysis of 119 AA kidney transplant recipients, and found that 58 (48.7%) carried two APOL1 kidney disease risk variants. Contrary to the association seen in native kidney disease, there is no difference in allograft survival at 5-year posttransplant for recipients with high-risk APOL1 genotypes. Thus, we were able to conclude that APOL1 genotypes do not increase risk of allograft loss after kidney transplantations, and carrying 2 APOL1 risk alleles should not be an impediment to transplantation.
authors.affiliation: Department of Medicine, Division of Nephrology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: B T
authors.initials: BT
authors.lastname: Lee
authors.forename: V
authors.initials: V
authors.lastname: Kumar
authors.forename: T A
authors.initials: TA
authors.lastname: Williams
authors.forename: R
authors.initials: R
authors.lastname: Abdi
authors.forename: A
authors.initials: A
authors.lastname: Bernhardy
authors.forename: C
authors.initials: C
authors.lastname: Dyer
authors.forename: S
authors.initials: S
authors.lastname: Conte
authors.forename: G
authors.initials: G
authors.lastname: Genovese
authors.forename: M D
authors.initials: MD
authors.lastname: Ross
authors.forename: D J
authors.initials: DJ
authors.lastname: Friedman
authors.forename: R
authors.initials: R
authors.lastname: Gaston
authors.forename: E
authors.initials: E
authors.lastname: Milford
authors.forename: M R
authors.initials: MR
authors.lastname: Pollak
authors.forename: A
authors.initials: A
authors.lastname: Chandraker
mesh_terms: D000328:Adult; D000075944:Apolipoprotein L1; D001053:Apolipoproteins / Q000235:genetics*; D044383:Black People / Q000235:genetics*; D005838:Genotype; D006085:Graft Survival / Q000235:genetics*; D006801:Humans; D016030:Kidney Transplantation; D008075:Lipoproteins, HDL / Q000235:genetics*; D008875:Middle Aged; D001741:Black or African American
chemical_list: C108666:APOL1 protein, human; D000075944:Apolipoprotein L1; D001053:Apolipoproteins; D008075:Lipoproteins, HDL