title: A stochastic markov model of cellular response to radiation.
abstract: A stochastic model based on the Markov Chain Monte Carlo process is used to describe responses to ionizing radiation in a group of cells. The results show that where multiple relationships linearly depending on the dose are introduced, the overall reaction shows a threshold, and, generally, a non-linear response. Such phenomena have been observed and reported in a number of papers. The present model permits the inclusion of adaptive responses and bystander effects that can lead to hormetic effects. In addition, the model allows for incorporating various time-dependent phenomena. Essentially, all known biological effects can be reproduced using the proposed model.
authors.affiliation: The Andrzej Soltan Institute for Nuclear Studies, Poland.
authors.forename: Krzysztof Wojciech
authors.initials: KW
authors.lastname: Fornalski
authors.forename: Ludwik
authors.initials: L
authors.lastname: Dobrzyński
authors.forename: Marek Krzysztof
authors.initials: MK
authors.lastname: Janiak