title: Influence of dendritic cells on B-cell responses during HIV infection.
abstract: Dendritic cells (DCs) modulate B-cell differentiation, activation, and survival mainly through production of growth factors such as B lymphocyte stimulator (BLyS/BAFF). DC populations have been reported to be affected in number, phenotype and function during HIV infection and such alterations may contribute to the dysregulation of the B-cell compartment. Herein, we reflect on the potential impact of DC on the pathogenesis of HIV-related B cell disorders, and how DC status may modulate the outcome of mucosal B cell responses against HIV, which are pivotal to the control of disease. A concept that could be extrapolated to the overall outcome of HIV disease, whereby control versus progression may reside in the host's capacity to maintain DC homeostasis at mucosal sites, where DC populations present an inherent capacity of modulating the balance between tolerance and protection, and are amongst the earliest cell types to be exposed to the virus.
authors.affiliation: Laboratoire d'immunogénétique, Centre de Recherche du Centre Hospitalier de l'Université de Montréal, Hôpital Notre-Dame, 2099 Alexandre De Sève, Montréal, QC, Canada H2L 2W5. johanne.poudrier@crchum.qc.ca
authors.forename: Johanne
authors.initials: J
authors.lastname: Poudrier
authors.forename: Josiane
authors.initials: J
authors.lastname: Chagnon-Choquet
authors.forename: Michel
authors.initials: M
authors.lastname: Roger
mesh_terms: D000818:Animals; D053264:B-Cell Activating Factor / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology* / Q000473:pathology / Q000821:virology; D003713:Dendritic Cells / Q000276:immunology* / Q000473:pathology / Q000821:virology; D018450:Disease Progression; D006678:HIV / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology* / Q000473:pathology / Q000821:virology; D006801:Humans; D007108:Immune Tolerance; D018928:Immunity, Mucosal; D051379:Mice; D008822:Mice, Transgenic; D009092:Mucous Membrane / Q000276:immunology* / Q000473:pathology / Q000821:virology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology / Q000473:pathology / Q000821:virology
chemical_list: D053264:B-Cell Activating Factor