title: Epimerization free synthesis of O-acyl isodipeptides employing COMU.
abstract: O-Acyl isodipeptides are prepared by coupling Boc-Ser/Thr-OBzl with Fmoc-Xaa-OH employing COMU, well known third generation peptide coupling agent. The reaction proceeds with high yield and the chemical homogeneity of the synthesized molecules were established via chiral HPLC analyses. The O-acyl isodipeptide units play crucial role in the success of ' click peptide'  protocol employed for assembling ' difficult sequence'  peptides.
authors.affiliation: Department of Studies in Chemistry, Central College Campus, Bangalore University, Dr. B. R. Ambedkar Veedhi, Bangalore -560 001, India.
authors.forename: M
authors.initials: M
authors.lastname: Samarasimhareddy
authors.forename: Hosahalli P
authors.initials: HP
authors.lastname: Hemantha
authors.forename: Kuppanna
authors.initials: K
authors.lastname: Ananda
authors.forename: Vommina V
authors.initials: VV
authors.lastname: Sureshbabu
mesh_terms: D000595:Amino Acid Sequence; D016229:Amyloid beta-Peptides; D002851:Chromatography, High Pressure Liquid; D057930:Click Chemistry / Q000379:methods*; D004151:Dipeptides / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010446:Peptide Fragments
chemical_list: D016229:Amyloid beta-Peptides; D004151:Dipeptides; D010446:Peptide Fragments