title: Copper-free route to triazole-modified peptidomimetic by the combination of two multicomponent reactions in one pot.
abstract: An efficient copper-free protocol for the synthesis of 5-methyl-1H-1,2,3-triazole-modified peptidomimetics through the combination of Ugi four-component reaction with a three-component cycloaddition, has been developed. The copper-free straightforward process is suitable for drug discovery. The chemoselective preparation of 1,4-disubstituted, triazole-modified peptidomimetics by using alkynyl substituted amines may have potential biological and synthetic application. At last, a "Lapinski type" analysis of the physical properties was performed, which is expected to help drug discovery.
authors.affiliation: Chemical Engineering College, Nanjing University of Science and Technology , Nanjing, 210094, P. R. China.
authors.forename: Teng-fei
authors.initials: TF
authors.lastname: Niu
authors.forename: Lin
authors.initials: L
authors.lastname: Gu
authors.forename: Wen-bin
authors.initials: WB
authors.lastname: Yi
authors.forename: Chun
authors.initials: C
authors.lastname: Cai
mesh_terms: D003300:Copper / Q000737:chemistry*; D055808:Drug Discovery; D018716:Molecular Mimicry; D010455:Peptides / Q000737:chemistry*; D014230:Triazoles / Q000737:chemistry*
chemical_list: D010455:Peptides; D014230:Triazoles; D003300:Copper