title: Ozonized autohemotransfusion does not affect arterial vasodilation in patients with peripheral arterial disease.
abstract: Ozonized autohemotransfusion has been used as a complementary therapy in patients with peripheral arterial disease (PAD). To determine whether ozone therapy could acutely modify artery vasodilatory capacity, a flow-mediated dilation test was performed at the brachial artery level before and after an ozonized autohemotransfusion in 16 patients with PAD, mean (± SD) age 55±1.8 years, and 14 healthy volunteers matched for age, sex and body mass index. Before ozonized autohemotransfusion, the mean baseline diameter of the brachial artery was higher in PAD patients than in healthy subjects (4.6±0.54 mm versus 3.6±0.54 mm, P<0.001) while mean flow-mediated brachial artery dilation and percentage of increase in flow were significantly lower in PAD patients than in controls (6.3±6.1% versus 11.8±2.4%, P<0.02; 433±61% versus 580±46%, P<0.02, respectively). No significant changes were observed after ozonized autohemotransfusion, indicating that ozonized autohemotransfusion does not modify endothelium-dependent ischemia-induced vascular reactivity.
authors.affiliation: Department of Geriatrics and Metabolic Diseases.
authors.forename: Antonino
authors.initials: A
authors.lastname: Coppola
authors.forename: Ludovico
authors.initials: L
authors.lastname: Coppola
authors.forename: Carlo
authors.initials: C
authors.lastname: Luongo
authors.forename: Alessandro
authors.initials: A
authors.lastname: Arciello
authors.forename: Federico
authors.initials: F
authors.lastname: Cacciapuoti
authors.forename: Diana
authors.initials: D
authors.lastname: Lama
authors.forename: Margherita
authors.initials: M
authors.lastname: Luongo
authors.forename: Luigi
authors.initials: L
authors.lastname: Ruggiero
authors.forename: Agostino
authors.initials: A
authors.lastname: Pastore
authors.forename: Giorgio
authors.initials: G
authors.lastname: Gombos