title: Casein hydrolysate for uterine infection treatment: a patent evaluation (WO2011132191).
abstract: Metritis, endometritis and pyometra are common uterus inflammatory diseases, occurring mainly in the early postpartum period of livestock and farm animals. These infections are primarily associated with contamination of the reproductive tract, in particular uterine. Uterine infections bring to uterine and cervical involution as well as sub-fertility; the high economic loss, due to costs for treatment, milk withdrawal, reduced reproductive performance and premature culling, clearly demonstrate that uterine health in the postpartum period requires substantial medical veterinary attention. A wide variety of therapies for endometritis have been reported, including mainly antibiotics administered either by systemic or local somministration. Here, the patent application WO/2011/132191, which describes an alternative treatment for uterine infection, using casein peptides, is evaluated and discussed.
authors.affiliation: University of Padova, Department of Biomedical Science, Viale G. Colombo 5 35131 Padova, Italy. giorgio.cozza@unipd.it
authors.forename: Giorgio
authors.initials: G
authors.lastname: Cozza
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000009:adverse effects / Q000737:chemistry / Q000191:economics / Q000627:therapeutic use*; D002364:Caseins / Q000009:adverse effects / Q000737:chemistry / Q000191:economics / Q000627:therapeutic use; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy* / Q000191:economics / Q000382:microbiology / Q000503:physiopathology; D003362:Cost-Benefit Analysis; D003612:Dairying / Q000191:economics; D016527:Drug Costs; D024881:Drug Resistance, Bacterial; D004716:Endometritis / Q000188:drug therapy / Q000191:economics / Q000382:microbiology / Q000503:physiopathology / Q000662:veterinary*; D005260:Female; D005298:Fertility / Q000187:drug effects; D007880:Legislation, Drug; D010330:Patents as Topic; D049590:Postpartum Period; D055112:Pyometra / Q000188:drug therapy / Q000191:economics / Q000382:microbiology / Q000503:physiopathology / Q000662:veterinary*; D016896:Treatment Outcome; D014599:Uterus / Q000187:drug effects* / Q000382:microbiology / Q000503:physiopathology
chemical_list: D000890:Anti-Infective Agents; D002364:Caseins; C475729:casein hydrolysate