title: Antiviral activity of Inonotus obliquus fungus extract towards infection caused by hepatitis C virus in cell cultures.
abstract: Fractions of Inonotus obliquus fungus water extract exhibited a virucidal effect towards hepatitis C virus: it 100-fold reduced its infective properties within 10 min. The antiviral effects of fungus extracts manifested after preventive (24 h before infection) and therapeutic use (during infection of porcine embryo kidney cells). Moreover, the data indicate that the birch fungus extracts inhibit production of infective virus by porcine embryo kidney cells.
authors.affiliation: D. I. Ivanovsky Institute of Virology, Ministry of Health Care and Social Development of the Russian Federation, Moscow, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Shibnev
authors.forename: D V
authors.initials: DV
authors.lastname: Mishin
authors.forename: T M
authors.initials: TM
authors.lastname: Garaev
authors.forename: N P
authors.initials: NP
authors.lastname: Finogenova
authors.forename: A G
authors.initials: AG
authors.lastname: Botikov
authors.forename: P G
authors.initials: PG
authors.lastname: Deryabin
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001487:Basidiomycota / Q000737:chemistry*; D002478:Cells, Cultured; D005260:Female; D016174:Hepacivirus / Q000187:drug effects*; D019698:Hepatitis C, Chronic / Q000821:virology; D006801:Humans; D012997:Solvents / Q000737:chemistry; D013552:Swine; D014771:Virion / Q000187:drug effects; D014867:Water / Q000737:chemistry
chemical_list: D000998:Antiviral Agents; D012997:Solvents; D014867:Water