title: Immunogenicity of HIV virus-like particles in rhesus macaques by intranasal administration.
abstract: Female rhesus macaques were immunized with HIV virus-like particles (HIV-VLPs) or HIV DNA administered as sequential combinations of mucosal (intranasal) and systemic (intramuscular) routes, according to homologous or heterologous prime-boost schedules. The results show that in rhesus macaques only the sequential intranasal and intramuscular administration of HIV-VLPs, and not the intranasal alone, is able to elicit humoral immune response at the systemic as well as the vaginal level.
authors.affiliation: Laboratory of Molecular Biology and Viral Oncogenesis, Istituto Nazionale Tumori Fond. G. Pascale, Naples, Italy. lbuonaguro@tin.it
authors.forename: Luigi
authors.initials: L
authors.lastname: Buonaguro
authors.forename: Maria
authors.initials: M
authors.lastname: Tagliamonte
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Visciano
authors.forename: Hanne
authors.initials: H
authors.lastname: Andersen
authors.forename: Mark
authors.initials: M
authors.lastname: Lewis
authors.forename: Ranajit
authors.initials: R
authors.lastname: Pal
authors.forename: Maria Lina
authors.initials: ML
authors.lastname: Tornesello
authors.forename: Ulf
authors.initials: U
authors.lastname: Schroeder
authors.forename: Jorma
authors.initials: J
authors.lastname: Hinkula
authors.forename: Britta
authors.initials: B
authors.lastname: Wahren
authors.forename: Franco M
authors.initials: FM
authors.lastname: Buonaguro
mesh_terms: D016915:AIDS Vaccines / Q000008:administration & dosage* / Q000276:immunology*; D000281:Administration, Intranasal; D000818:Animals; D001769:Blood / Q000276:immunology; D005260:Female; D006678:HIV / Q000276:immunology*; D015483:HIV Antibodies / Q000032:analysis / Q000097:blood; D007273:Injections, Intramuscular; D008253:Macaca mulatta; D014611:Vaccination / Q000379:methods; D019444:Vaccines, DNA / Q000008:administration & dosage* / Q000276:immunology*; D022721:Vaccines, Virosome / Q000008:administration & dosage / Q000276:immunology; D014621:Vagina / Q000276:immunology
chemical_list: D016915:AIDS Vaccines; D015483:HIV Antibodies; D019444:Vaccines, DNA; D022721:Vaccines, Virosome