title: [Chronic renal failure causes bone fragility and blood vessel stiffening].
abstract: Chronic renal failure results in disturbances of bone formation, degradation and mineralization and changes in bone volume. These bone changes as well as biochemical abnormalities of the blood have also been found to be associated with soft-tissue and blood vessel calcification. In fact, the patients suffer not only from skeletal problems but also from rapidly progressing arterial stiffening, which leads to early cardiovascular morbidity and mortality. Essential therapy consists of early management of hyperphosphatemia and supplementation of active vitamin D.
authors.affiliation: Porvoon sairaala, sisätautien klinikka.
authors.forename: Satu
authors.initials: S
authors.lastname: Keronen
authors.forename: Leena
authors.initials: L
authors.lastname: Martola
authors.forename: Eero
authors.initials: E
authors.lastname: Honkanen
mesh_terms: D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000209:etiology* / Q000517:prevention & control*; D006801:Humans; D054559:Hyperphosphatemia / Q000209:etiology* / Q000517:prevention & control*; D007676:Kidney Failure, Chronic / Q000150:complications*; D059289:Vascular Stiffness; D014807:Vitamin D / Q000627:therapeutic use*
chemical_list: D014807:Vitamin D