title: [With the scalpel against the immune system: HIV infection complicated by an unclear colitis].
abstract: A 35-year-old Kenian lady with advanced immunodeficiency due to HIV infection started on an antiretroviral therapy. Five months later, a severe colitis was diagnosed, however, no causal pathogen could be found. In order to avoid imminent perforation, a hemicolectomy became necessary, and immediately the symptoms and inflammation markers normalized rapidly. M. tuberculosis could be proven in culture in a draining abdominal lymph node. We assume that the severe inflammation was caused by an immune restoration inflammatory syndrome (IRIS). Essentials in diagnosis, pathogenesis and therapy of IRIS are discussed.
authors.affiliation: I. Med. Klinik und Poliklinik, Universitätsmedizin Mainz.
authors.forename: P
authors.initials: P
authors.lastname: Ploch
authors.forename: C C
authors.initials: CC
authors.lastname: Schimanski
authors.forename: M
authors.initials: M
authors.lastname: Goetz
authors.forename: C
authors.initials: C
authors.lastname: Orth
authors.forename: H
authors.initials: H
authors.lastname: Lang
authors.forename: P R
authors.initials: PR
authors.lastname: Galle
authors.forename: M
authors.initials: M
authors.lastname: Schuchmann
authors.forename: J M
authors.initials: JM
authors.lastname: Kittner
mesh_terms: D000328:Adult; D003092:Colitis / Q000175:diagnosis* / Q000628:therapy*; D005260:Female; D015658:HIV Infections / Q000175:diagnosis* / Q000628:therapy*; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000175:diagnosis* / Q000628:therapy*; D016896:Treatment Outcome