title: Plasma adiponectin levels predict cardiovascular events in the observational Arita Cohort Study in Japan: the importance of the plasma adiponectin levels.
abstract: As the plasma level of adiponectin is related to metabolic syndrome and cardiovascular events, a low plasma adiponectin level may either cause or trigger cardiovascular disorders. The purpose of this study was to determine whether a low adiponectin level contributes to cardiovascular events, and to investigate the factors influencing adiponectin in the Japanese Arita-cho cohort study.We followed about 2000 subjects in Arita-cho, Saga, Japan as a cohort study, and we enrolled 637 subjects (205 men; 65.1±8.3 years old) who participated in annual health checks from 2005 to 2008 and underwent measurement of the plasma adiponectin level and an oral glucose tolerance test. We monitored the incidence of cardiovascular or cerebrovascular events in these subjects until the end of 2010, discontinuing follow-up at 3 years after the start of enrollment. Subjects with low plasma adiponectin levels (<10.5 ng ml(-1)) had a higher incidence of newly diagnosed cardiovascular diseases such as acute heart failure or acute myocardial infarction than those with high plasma adiponectin levels (≥10.5 ng ml(-1)) over an average of 2.95 years of follow-up. Multivariate analysis showed that the adiponectin level was predicted by the following parameters in all subjects: age (β=0.16), male gender (β=-0.267), homeostasis model assessment of insulin resistance (β=-0.140) and the plasma levels of high-density lipoprotein cholesterol (β=0.104), uric acid (β=-0.13), triglycerides (β=-0.169) and brain natriuretic peptide (β=0.151). The difference in plasma glucose before and 120 min after the intake of a 75-g glucose load did not influence the plasma adiponectin level. The plasma adiponectin level is useful for predicting cardiovascular events, and is a measure of the risk of lifestyle-related diseases.
authors.affiliation: Department of Cardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan.
authors.forename: Chun-Yen
authors.initials: CY
authors.lastname: Chen
authors.forename: Masanori
authors.initials: M
authors.lastname: Asakura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Asanuma
authors.forename: Takuya
authors.initials: T
authors.lastname: Hasegawa
authors.forename: Jun
authors.initials: J
authors.lastname: Tanaka
authors.forename: Norihisa
authors.initials: N
authors.lastname: Toh
authors.forename: Kyung-Duk
authors.initials: KD
authors.lastname: Min
authors.forename: Hideaki
authors.initials: H
authors.lastname: Kanzaki
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Takahama
authors.forename: Makoto
authors.initials: M
authors.lastname: Amaki
authors.forename: Yumi
authors.initials: Y
authors.lastname: Itoh
authors.forename: Go
authors.initials: G
authors.lastname: Ichien
authors.forename: Yoko
authors.initials: Y
authors.lastname: Okumoto
authors.forename: Toru
authors.initials: T
authors.lastname: Funahashi
authors.forename: Jiyoong
authors.initials: J
authors.lastname: Kim
authors.forename: Masafumi
authors.initials: M
authors.lastname: Kitakaze
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000368:Aged; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000097:blood* / Q000453:epidemiology / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D002561:Cerebrovascular Disorders / Q000097:blood / Q000453:epidemiology; D015331:Cohort Studies; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D007564:Japan / Q000453:epidemiology; D053208:Kaplan-Meier Estimate; D008019:Life Style; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012737:Sex Factors
chemical_list: D052242:Adiponectin; D015415:Biomarkers; D001786:Blood Glucose; D007328:Insulin