title: Serum anti-Müllerian hormone levels are lower in reproductive-age women with Crohn's disease compared to healthy control women.
abstract: OBJECTIVE
  Crohn's disease (CD) decreases fertility both directly, by inducing inflammation in the fallopian tubes and ovaries, and indirectly, through the surgical interventions and tubal adhesions associated with disease treatment. Anti-müllerian hormone (AMH) is a reliable indicator of ovarian reserve in women. We aimed to compare serum AMH levels between reproductive-age women with CD and healthy controls.
  
  
  METHODS
  Serum AMH levels were measured by ELISA in 35 women with CD and 35 age-matched healthy women controls.
  
  
  RESULTS
  CD patients and controls were similar in terms of age, height, weight and BMI. Mean CD duration was 60 months. CRP, ESR and leukocyte counts were significantly higher in CD patients compared to the controls (p<0.001, p=0.004 and p=0.04, respectively). AMH levels in CD patients (1.02 ± 0.72) were significantly lower compared to the controls (1.89 ± 1.80) (p = 0.009). Serum AMH levels in CD patients with active disease (0.33 ± 0.25) were significantly lower compared to CD patients who were in remission (1.53 ± 0.49) (p = 0.001). Serum AMH levels were similar in CD patients with a disease duration of less than 5 years (17 patients) and CD patients with a disease duration of greater than 5 years (18 patients) (p = 0.8). In CD patients, a negative correlation between CDAI and serum AMH levels was found (r = -0.718, p < 0.001). Serum AMH levels were similar in CD patients who had (6 patients) and had not undergone (29 patients) surgical treatment (p = 0.2).
  
  
  CONCLUSIONS
  Serum AMH levels of reproductive-age women with CD were significantly lower compared to the controls. CDAI and AMH are inversely correlated.
authors.affiliation: Haydarpaşa Numune Education and Research Hospital, Department of Gastroenterology, Turkey. ebubekirsenates@yahoo.com
authors.forename: Ebubekir
authors.initials: E
authors.lastname: Şenateş
authors.forename: Yaşar
authors.initials: Y
authors.lastname: Çolak
authors.forename: Emrullah Düzgün
authors.initials: ED
authors.lastname: Erdem
authors.forename: Atakan
authors.initials: A
authors.lastname: Yeşil
authors.forename: Ender
authors.initials: E
authors.lastname: Coşkunpınar
authors.forename: Önder
authors.initials: Ö
authors.lastname: Şahin
authors.forename: Mustafa Erhan
authors.initials: ME
authors.lastname: Altunöz
authors.forename: Ilyas
authors.initials: I
authors.lastname: Tuncer
authors.forename: Ayşe O
authors.initials: AO
authors.lastname: Kurdaş Övünç
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000378:metabolism; D016022:Case-Control Studies; D003424:Crohn Disease / Q000097:blood* / Q000601:surgery; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D010053:Ovary / Q000503:physiopathology; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D013997:Time Factors; D055815:Young Adult
chemical_list: D054304:Anti-Mullerian Hormone; D002097:C-Reactive Protein