title: An evaluation on the neuropsychological tests used in the assessment of postchemotherapy cognitive changes in breast cancer survivors.
abstract: OBJECTIVE
  The choice of appropriate neuropsychological tests is important in evaluating the onset, severity, duration, and site of cognitive changes in postchemotherapy breast cancer survivors. This literature review is designed to evaluate and provide a summary of suitable neuropsychological tests to determine cognitive changes in breast cancer survivors.
  
  
  METHODS
  A literature search restricted to publications in English before June 2011 was performed using the following combination of keywords: "neuropsychological assessments," "breast cancer," "chemotherapy," and "cognitive impairment." Only observational studies that performed cognitive assessments on breast cancer survivors were included. The neuropsychological assessments were grouped as "objective" (traditional batteries and screening tests), "subjective," or "computerized."
  
  
  RESULTS
  Of the 43 studies extracted, memory (88 %) and attention/concentration (88 %) are the two most commonly assessed domains. A majority (63 %) employed the use of Wechsler Adult Intelligent Scale (an objective test), while only 49 % incorporated subjective assessments to assess perceived cognitive impairment. Computerized tests received low popularity (28 %) despite their numerous advantages, which include overcoming the language- and cultural-dependent limitations of traditional objective tests.
  
  
  CONCLUSIONS
  In the selection of a suitable neuropsychological tool to determine the onset, severity, site, and duration of cognitive changes in breast cancer survivors, incorporation of both subjective and objective tests is essential to facilitate a comprehensive assessment. With more validation work performed in future studies, it may be feasible to employ computerized neuropsychological assessments in both clinical and research settings.
authors.affiliation: Department of Pharmacy, National University of Singapore, 18 Science Drive 4, Blk S4, Singapore 117543, Singapore.
authors.forename: Yin Ting
authors.initials: YT
authors.lastname: Cheung
authors.forename: Earl Hsien-Jie
authors.initials: EH
authors.lastname: Tan
authors.forename: Alexandre
authors.initials: A
authors.lastname: Chan
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy / Q000523:psychology*; D003072:Cognition Disorders / Q000139:chemically induced*; D003936:Diagnosis, Computer-Assisted; D005260:Female; D006801:Humans; D009483:Neuropsychological Tests / Q000592:standards*; D012720:Severity of Illness Index; D017741:Survivors; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents