title: Multidisciplinary intervention with sibutramine: assessing successful weight loss predictors in military adolescent dependents.
abstract: OBJECTIVE
  Assess body mass index (BMI) reduction through a multidisciplinary intervention with sibutramine in adolescents of military parents and examine characteristics and behavioral traits as predictors of successful weight loss.
  
  
  METHODS
  A prospective study where participants received sibutramine daily for 6 months. Adolescents ages 12 to 18 with BMI-for-age and sex greater than 95 percentile and good health were enrolled. Outcome variables are BMI, biochemical indices, and clinical measurements. Predictor variables are participant demographics, family history, lifestyle changes, and behavioral traits assessed with behavioral assessment for children.
  
  
  RESULTS
  One hundred participants were recruited with 81% completion. In those participants who completed the 6-month intervention, a mean participant BMI reduction of 3.1 kg/m2 (-9.3%) (p < 0.001; 95% CI: -10.5% to -7.9%) was obtained with 79% successfully meeting the weight loss goal. Sibutramine dose was increased from 10 to 15 mg at 3 months for participant with <2.5% BMI reduction from baseline. Sibutramine dose at 3 months (p < 0.001) and participants perception of relationship with parents (p = 0.05) were statistically significant predictors of successful weight loss (> or =10% reduction in BMI).
  
  
  CONCLUSIONS
  Sibutramine was effective at promoting minimum beneficial BMI reduction of 5% in adolescents with service-connected parents; however, increasing dosage at 3 months did not improve the likelihood of being successful.
authors.affiliation: Family Medicine, Madigan Army Medical Center, 9040 Fitzsimmons Drive, Lewis McChord, WA 98431, USA.
authors.forename: Jorge L
authors.initials: JL
authors.lastname: Cabrera
authors.forename: Edward G
authors.initials: EG
authors.lastname: Wilks
authors.forename: Jenna E
authors.initials: JE
authors.lastname: Symons
authors.forename: Kwabena L
authors.initials: KL
authors.lastname: Blankson
authors.forename: Renee E
authors.initials: RE
authors.lastname: Cole
mesh_terms: D000293:Adolescent; D019440:Anti-Obesity Agents / Q000627:therapeutic use*; D001067:Appetite Depressants / Q000627:therapeutic use*; D015992:Body Mass Index; D002648:Child; D003131:Combined Modality Therapy; D003376:Counseling; D003503:Cyclobutanes / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008019:Life Style; D008297:Male; D008889:Military Personnel; D050177:Overweight / Q000517:prevention & control*; D011446:Prospective Studies; D015431:Weight Loss / Q000187:drug effects*
chemical_list: D019440:Anti-Obesity Agents; D001067:Appetite Depressants; D003503:Cyclobutanes; C058254:sibutramine