title: Turning Dicer on its head.
abstract: Recent structural analysis of full-length human Dicer supports a new model of the enzyme's domain arrangement and provides a structural basis for many of Dicer's biochemical attributes.
authors.forename: Ahilya N
authors.initials: AN
authors.lastname: Sawh
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Duchaine
mesh_terms: D000818:Animals; D053487:DEAD-box RNA Helicases / Q000737:chemistry*; D006801:Humans; D043244:Ribonuclease III / Q000737:chemistry*
chemical_list: C408087:DICER1 protein, human; D043244:Ribonuclease III; D053487:DEAD-box RNA Helicases