title: [Successful management of liver metastasis from gastric adenosquamous carcinoma with adjuvant chemotherapy and radiofrequency ablation].
abstract: A 70-year-old man was given a diagnosis of advanced type 3 gastric cancer and underwent surgery. In addition to total gastrectomy and D2 lymph node resection, partial liver resection was performed due to detection of a solitary liver metastasis which was initially overlooked on preoperative CT. Histopathologically, the tumor was diagnosed as gastric adenosquamous carcinoma (Int, INFβ, pT2 (ss), H1, ly1, v2 (mp), EVG, n (-), pPM (-), pDM (-)). Three metastasic lesions appeared in the liver on abdominal CT scan performed 3 months after the operation. The patient underwent adjuvant chemotherapy with S-1. Since enlargement of the liver metastases was observed following 2 courses of treatment, the patient received combination chemotherapy of irinotecan and cisplatin. Of 3 metastatic lesions, 1 disappeared and 2 decreased to less than 2 cm in diameter after 8 courses of 2nd line treatment. Radiofrequency ablation (RFA) was successfully performed to treat the remaining liver metastases. The patient has been free of recurrence for 41 months.
authors.affiliation: Department of Internal Medicine, Nagasaki Municipal Medical Center. y-fukuda@ngs2.cncm.ne.jp
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Fukuda
authors.forename: Fuminao
authors.initials: F
authors.lastname: Takeshima
authors.forename: Kumi
authors.initials: K
authors.lastname: Ogihara
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Shoji
authors.forename: Yuko
authors.initials: Y
authors.lastname: Akazawa
authors.forename: Takuya
authors.initials: T
authors.lastname: Tsutsumi
authors.forename: Kuniko
authors.initials: K
authors.lastname: Abe
authors.forename: Youhei
authors.initials: Y
authors.lastname: Mizuta
authors.forename: Hajime
authors.initials: H
authors.lastname: Isomoto
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Nakao
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives; D018196:Carcinoma, Adenosquamous / Q000473:pathology*; D017115:Catheter Ablation; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D006801:Humans; D000077146:Irinotecan; D008113:Liver Neoplasms / Q000556:secondary* / Q000628:therapy*; D008297:Male; D013274:Stomach Neoplasms / Q000473:pathology*
chemical_list: D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D000077146:Irinotecan; D002945:Cisplatin; D002166:Camptothecin