title: Novel phytonutrient contributors to antioxidant protection against cardiovascular disease.
abstract: The associations linking endothelial inflammation, endothelial oxidative stress, and atherogenesis and the potential for dietary phytonutrients to decrease the impact of these associations were assessed. A detailed literature review was conducted and summarized. A large body of scientific evidence describes the interactions among endothelial inflammation, endothelial oxidative stress, and atherogenesis. A growing body of research indicates that several dietary phytonutrients (astaxanthin, lycopene, lutein, and glabridin) can decrease the risk for atherosclerosis by decreasing endothelial inflammation and oxidative stress. The consumption of foods or dietary supplements that provide astaxanthin, lycopene, lutein, and glabridin can ameliorate endothelial inflammation and oxidative stress, retard atherogenesis, and decrease the risk for atherogenic cardiovascular disease.
authors.affiliation: Cardiology Unit, San Camillo de Lellis Hospital, Manfredonia, Foggia, Italy. griccioni@hotmail.com
authors.forename: Graziano
authors.initials: G
authors.lastname: Riccioni
authors.forename: Lorenza
authors.initials: L
authors.lastname: Speranza
authors.forename: Mirko
authors.initials: M
authors.lastname: Pesce
authors.forename: Salvatore
authors.initials: S
authors.lastname: Cusenza
authors.forename: Nicolantonio
authors.initials: N
authors.lastname: D'Orazio
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Glade
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D050197:Atherosclerosis / Q000517:prevention & control*; D002338:Carotenoids / Q000494:pharmacology / Q000627:therapeutic use*; D004032:Diet; D004730:Endothelium, Vascular / Q000187:drug effects*; D006801:Humans; D007529:Isoflavones / Q000494:pharmacology / Q000627:therapeutic use*; D010636:Phenols / Q000494:pharmacology / Q000627:therapeutic use*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D007529:Isoflavones; D010636:Phenols; D010936:Plant Extracts; D002338:Carotenoids; C107601:glabridin