title: Synthesis, biological activity and docking study of imidazol-5-one as novel non-nucleoside HIV-1 reverse transcriptase inhibitors.
abstract: A novel series of substituted imidazol-5-ones were designed, synthesized and evaluated for in vitro reverse transcriptase (RT) inhibition activity using reverse transcriptase assay kit (Roche, Colorimetric). It has been observed from in vitro screening that newly synthesized compounds possess RT inhibitory activity. Docking study was performed to study the binding orientation and affinity of synthesized compounds for RT enzyme.
authors.affiliation: Dr. Rafiq Zakaria Campus, YB Chavan College of Pharmacy, Aurangabad, Maharashtra, India.
authors.forename: Santosh N
authors.initials: SN
authors.lastname: Mokale
authors.forename: Deepak
authors.initials: D
authors.lastname: Lokwani
authors.forename: Devanand B
authors.initials: DB
authors.lastname: Shinde
mesh_terms: D001665:Binding Sites; D003198:Computer Simulation; D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D015497:HIV-1 / Q000187:drug effects; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D017434:Protein Structure, Tertiary; D018894:Reverse Transcriptase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D007093:Imidazoles; D018894:Reverse Transcriptase Inhibitors; C029899:imidazole; C514824:reverse transcriptase, Human immunodeficiency virus 1; D054303:HIV Reverse Transcriptase