title: Lack of associations of polymorphisms of IL-7R, IL-13 and IL-15 with NSCLCs in non-smoking Chinese.
abstract: Studies have shown that immune cells play a key role in lung cancer development. Five SNPs (rs1494555, rs7737000, rs20541, rs1057972 and rs2857261) are associated with lung cancer risk among Caucasians and/or African-Americans, but the polymorphisms may be implicated in different susceptibilities for lung cancer across different populations because of underlying genetic heterogeneity. We therefore conducted a study to examine this relationship in non-smoking Chinese. As a result , no significant associations were observed between SNPs and NSCLCs, whetehr of squamous cell or adenocarcinoma type. Results indicated polymorphisms of IL-7R, IL-13 and IL-15 are not major contributors to NSCLC susceptibility, although we can not rule out synergistic effects with cigarette smoke in NSCLC development in smoking Chinese.
authors.affiliation: Department of Integration of Traditional Chinese and Western Medicine, Zhejiang cancer hospital, Hangzhou, China.
authors.forename: Wen-Long
authors.initials: WL
authors.lastname: Bao
authors.forename: Hua
authors.initials: H
authors.lastname: Shi
authors.forename: Ai-Qin
authors.initials: AQ
authors.lastname: Zhang
authors.forename: Xiang-Ming
authors.initials: XM
authors.lastname: Kong
authors.forename: De-Hou
authors.initials: DH
authors.lastname: Deng
authors.forename: Yong-Jun
authors.initials: YJ
authors.lastname: Zhang
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics; D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics*; D002294:Carcinoma, Squamous Cell / Q000235:genetics; D016022:Case-Control Studies; D002648:Child; D004247:DNA / Q000235:genetics; D005260:Female; D005500:Follow-Up Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D018793:Interleukin-13 / Q000235:genetics*; D019409:Interleukin-15 / Q000235:genetics*; D008175:Lung Neoplasms / Q000235:genetics; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D060888:Real-Time Polymerase Chain Reaction; D020395:Receptors, Interleukin-7 / Q000235:genetics*; D012307:Risk Factors; D012907:Smoking / Q000235:genetics*; D055815:Young Adult
chemical_list: D018793:Interleukin-13; D019409:Interleukin-15; D020395:Receptors, Interleukin-7; D004247:DNA