title: Glutathione S-transferase gene polymorphisms and risk of gastric cancer in a Chinese population.
abstract: OBJECTIVE
  The potential role of GSTM1, GSTT1 and GSTP1 polymorphisms in risk of gastric cancer in Chinese was studied.
  
  
  METHODS
  We collected 194 gastric cancers by pathologic examination and 412 controls from southern China during January 2007 to January 2011. Genotyping was based upon duplex polymerase-chain-reaction with the PCR-CTPP method.
  
  
  RESULTS
  Individuals carrying null GSTM1 and GSTT1 had 1.49 and 1.96 fold risk sof gastric cancer when compared with respective non-null genotypes. We also found a non-significant 37% excess risk of gastric cancer among carriers of GSTP1 1b/1b genotype when compared with 1a/1a genotype (OR=1.37, 95% CI=0.81-2.25). The combination of null/null GSTM1 and GSTT1 genotypes showed higher increased risk of gastric cancer (OR=3.17, 95% CI=1.68-4.21). Moreover, cancers in ever smokers and ever drinkers were observed to be strongly associated with null GSTM1 and GSTT1, and a significant cancer risk was observed in positive H.pylori infection individuals with null GSTT1.
  
  
  CONCLUSIONS
  Our study provided evidence that genetic deletion of GSTM1 and GSTT1 may contribute to increased susceptibility to gastric cancer in our Chinese population, while the GSTP1a/b polymorphism may not.
authors.affiliation: Department of General Surgery, Third Military Medical University, Guangzhou, China.
authors.forename: An-Ping
authors.initials: AP
authors.lastname: Zhang
authors.forename: Bao-Hua
authors.initials: BH
authors.lastname: Liu
authors.forename: Li
authors.initials: L
authors.lastname: Wang
authors.forename: Yu
authors.initials: Y
authors.lastname: Gao
authors.forename: Fan
authors.initials: F
authors.lastname: Li
authors.forename: Su-Xia
authors.initials: SX
authors.lastname: Sun
mesh_terms: D000328:Adult; D000368:Aged; D000428:Alcohol Drinking; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D004247:DNA / Q000235:genetics; D004198:Disease Susceptibility; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D051549:Glutathione S-Transferase pi / Q000235:genetics*; D005982:Glutathione Transferase / Q000235:genetics*; D016998:Helicobacter / Q000378:metabolism; D016481:Helicobacter Infections / Q000235:genetics / Q000378:metabolism / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D012307:Risk Factors; D012907:Smoking; D013274:Stomach Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000821:virology
chemical_list: D004247:DNA; D051549:Glutathione S-Transferase pi; D005982:Glutathione Transferase; C413545:glutathione S-transferase T1; C496556:GSTP1 protein, human