title: Synthesis and antibacterial activity against ralstonia solanacearum for novel hydrazone derivatives containing a pyridine moiety.
abstract: BACKGROUND
  Ralstonia solanacearum, one of the most important bacterial diseases on plants, is a devastating, soil-borne plant pathogen with a global distribution and an unusually wide host range. In order to discover new bioactive molecules and pesticides acting on tobacco bacterial wilt, we sought to combine the active structure of hydrazone and pyridine together to design and synthesize a series of novel hydrazone derivatives containing a pyridine moiety.
  
  
  RESULTS
  A series of hydrazone derivatives containing a pyridine moiety were synthesized. Their structures were characterized by 1 H-NMR, 13 C-NMR, IR, and elemental analysis. The preliminary biological activity tests showed that compound 3e and 3g exhibited more than 80% activity against Ralstonia solanacearum at 500 mg/L, especially compound 3g displayed relatively good activity to reach 57.0% at 200 mg/L.
  
  
  CONCLUSIONS
  A practical synthetic route to hydrazone derivatives containing a pyridine moiety by the reaction of intermediates 2 with different aldehydes in ethanol at room temperature using 2-chloronicotinic acid and 2-amino-5-chloro-3-methylbenzoic acid as start materials is presented. This study suggests that the hydrazone derivatives containing a substituted pyridine ring could inhibit the growth of Ralstonia solanacearum.
authors.affiliation: State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Guizhou University, Guiyang, China. basong@gzu.edu.cn.
authors.forename: Jian
authors.initials: J
authors.lastname: Wu
authors.forename: Shenghong
authors.initials: S
authors.lastname: Kang
authors.forename: Baoan
authors.initials: B
authors.lastname: Song
authors.forename: Deyu
authors.initials: D
authors.lastname: Hu
authors.forename: Ming
authors.initials: M
authors.lastname: He
authors.forename: Linhong
authors.initials: L
authors.lastname: Jin
authors.forename: Song
authors.initials: S
authors.lastname: Yang