title: Intermediate term outcomes with bifurcation coronary stenting using the paclitaxel drug-eluting stent: a single centre experience.
abstract: BACKGROUND
  Percutaneous treatment of bifurcation coronary artery disease (BCD) is complex and, in the era of bare metal stents (BMS), was reported to have a high rate of repeat target lesion revascularization (TLR). Paclitaxel drug-eluting stents (PES) have been used in the treatment of BCD, with better overall outcomes than BMS. Also, acute stent thrombosis (AST), with an incidence ranging from 2.7% to 4.3%, has been reported with the use of bifurcation PES, and remains a concern in treating these patients. In the present report, intermediate term outcomes with BCD stenting using TAXUS Express (Boston Scientific, USA) PES are presented from the Genesis Medical Center.
  
  
  METHODS
  In the present retrospective study, 518 consecutive de novo bifurcation stenting procedures are reported. They were performed in 2005 at the present institution using the TAXUS Express PES. Follow-up data on 312 patients (60.2%) was achieved through telephone interviews and reviews of medical records after a mean of 6.7 months. The primary end point of the present study was the combined end points of cardiac death, nonfatal myocardial infarction (MI) and TLR. Secondary outcomes included the individual end points of death, cardiac death, AST, target vessel revascularization (TVR), TLR, ST elevation MI and non-ST elevation MI on intermediate term follow-up.
  
  
  RESULTS
  The mean (± SD) age of the patients was 66±12 years. Acute procedural success was 95% (main branch, 99%; side branch, 95.9%). The following intermediate term outcomes with bifurcation drug-eluting stents were: TLR, 6.7%; TVR, 12.2%; definite and probable AST, 1.6%; death, 6.7%; cardiac death, 2.9%; non-ST elevation MI, 0.7%; ST elevation MI, 2.0%; and the combined primary end point, 9.9%. The outcomes for patients who underwent main branch stenting were not statistically different from those with bifurcation stenting, with an overall combined end point favouring main branch stenting alone (5.8% versus 10.8%, P not significant).
  
  
  CONCLUSIONS
  The TAXUS Express PES carry acceptable intermediate term outcomes in the treatment of BCD compared with historic controls with BMS, with low TLR, TVR and overall primary combined end point. Main branch stenting alone is safe, with a trend toward fewer adverse events than bifurcation stenting.
authors.affiliation: Midwest Cardiovascular Research Foundation, Davenport, Iowa, USA.
authors.forename: Nicolas W
authors.initials: NW
authors.lastname: Shammas
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Dippel
authors.forename: Gail A
authors.initials: GA
authors.lastname: Shammas
authors.forename: Leslie
authors.initials: L
authors.lastname: Farland
authors.forename: Stephanie
authors.initials: S
authors.lastname: Brosius
authors.forename: Michael
authors.initials: M
authors.lastname: Jerin
authors.forename: Amber
authors.initials: A
authors.lastname: Avila
authors.forename: Lauren
authors.initials: L
authors.lastname: Gehbauer
authors.forename: Matthew
authors.initials: M
authors.lastname: Winter
authors.forename: Penny
authors.initials: P
authors.lastname: Stoakes
authors.forename: Jeannette
authors.initials: J
authors.lastname: Byrd
authors.forename: Peter
authors.initials: P
authors.lastname: Sharis
authors.forename: Jon
authors.initials: J
authors.lastname: Robken