title: Role of microparticles in dengue virus infection and its impact on medical intervention strategies.
abstract: Dengue virus (DV) is one of the most important vector-borne diseases in the world. It causes a disease that manifests as a spectrum of clinical symptoms, including dengue hemorrhagic fever. DV is proficient at diverting the immune system to facilitate transmission through its vector host, Aedes spp. mosquito. Similar to other vector-borne parasites, dengue may also require a second structural form, a virus of alternative morphology (VAM), to complete its life cycle. DV can replicate to high copy numbers in patient plasma, but no classical viral particles can be detected by ultra-structural microscopy analysis. A VAM appearing as a microparticle has been recapitulated with in vitro cell lines Meg01 and K562, close relatives to the cells harboring dengue virus in vivo. VAMs are likely to contribute to the high viremia levels observed in dengue patients. This review discusses the possible existence of a VAM in the DV life cycle.
authors.affiliation: Department of Pathology and Laboratory Medicine, Emory Vaccine Center, Emory University School of Medicine, Atlanta, GA, USA.
authors.forename: Kristina
authors.initials: K
authors.lastname: Bargeron Clark
authors.forename: Hui-Mien
authors.initials: HM
authors.lastname: Hsiao
authors.forename: Sansanee
authors.initials: S
authors.lastname: Noisakran
authors.forename: Jih-Jin
authors.initials: JJ
authors.lastname: Tsai
authors.forename: Guey Chuen
authors.initials: GC
authors.lastname: Perng
mesh_terms: D000818:Animals; D055252:Cell-Derived Microparticles / Q000378:metabolism*; D003715:Dengue / Q000276:immunology / Q000628:therapy* / Q000635:transmission / Q000821:virology*; D053059:Dengue Vaccines / Q000276:immunology; D003716:Dengue Virus / Q000502:physiology* / Q000648:ultrastructure; D004199:Disease Vectors; D015195:Drug Design; D006801:Humans
chemical_list: D053059:Dengue Vaccines