title: Cell-penetrating peptides: classes, origin, and current landscape.
abstract: With more than ten new FDA approvals since 2001, peptides are emerging as an important therapeutic alternative to small molecules. However, unlike small molecules, peptides on the market today are limited to extracellular targets. By contrast, cell-penetrating peptides (CPPs) can target intracellular proteins and also carry other cargoes (e.g. other peptides, small molecules or proteins) into the cell, thus offering great potential as future therapeutics. In this review I present a classification scheme for CPPs based on their physical-chemical properties and origin, and I provide a general framework for understanding and discovering new CPPs.
authors.affiliation: Hoffmann-La Roche Inc., pRED Informatics, 340 Kingsland Street, Nutley, NJ, USA. francesca.milletti@roche.com
authors.forename: Francesca
authors.initials: F
authors.lastname: Milletti
mesh_terms: D057846:Cell-Penetrating Peptides / Q000737:chemistry / Q000145:classification*; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D019151:Peptide Library
chemical_list: D057846:Cell-Penetrating Peptides; D019151:Peptide Library