title: Design, synthesis, molecular docking and biological evaluation of new dithiocarbamates substituted benzimidazole and chalcones as possible chemotherapeutic agents.
abstract: A series of novel dithiocarbamates with benzimidazole and chalcone scaffold have been designed synthesised and evaluated for their antimitotic activity. Compounds 4c and 9d display the most promising antimitotic activity with IC(50) of 1.66 μM and 1.52 μM respectively.
authors.affiliation: Sarojini Naidu Vanitha Pharmacy Maha Vidyalaya, Osmania University, Hyderabad 500001, Andhra Pradesh, India.
authors.forename: Keerthana
authors.initials: K
authors.lastname: Bacharaju
authors.forename: Swathi Reddy
authors.initials: SR
authors.lastname: Jambula
authors.forename: Sreekanth
authors.initials: S
authors.lastname: Sivan
authors.forename: Saritha
authors.initials: S
authors.lastname: Jyostnatangeda
authors.forename: Vijjulatha
authors.initials: V
authors.lastname: Manga
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D001562:Benzimidazoles / Q000737:chemistry* / Q000494:pharmacology; D002219:Carbamates; D047188:Chalcones / Q000737:chemistry* / Q000494:pharmacology; D003198:Computer Simulation; D015195:Drug Design; D020128:Inhibitory Concentration 50; D011485:Protein Binding; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D001562:Benzimidazoles; D002219:Carbamates; D047188:Chalcones