title: Acrodermatitis enteropathica.
abstract: OBJECTIVE
  The aim of the work was the presentation of one case with Acrodermatitis enteropathica.
  
  
  METHODS
  Acrodermatitis enteropathica is diagnosed based on the pedigree, typical clinical manifestations on the skin, laboratory results, small bowel biopsy, skin biopsy and kariotype.
  
  
  RESULTS
  The patient was a two years old male toddler, hospitalized due to skin changes, chronic diarrhoea and total alopecia. Skin changes appeared on akral of the limbs, inguinal and perineal region, joints, perioral area and eyes. These changes appeared in different forms (erythematous, squamous, eczematiod, psoriasisforme and crusted). In the eyes were present these changes: blepharitis and conjunctivitis. Also total alopecia was prezent. Diarrhoea was chronic and specific. Laboratory findings showed the existence of sideropenic anemia, hypoproteinemia with hypoalbuminemia and low plasma zinc concentration (7.5 micromol/L). Hystopathological changes on the small bowel and skin biopsy were not typical for this disease. Following the beginning of treatment with zinc sulphate, all clinical skin manifestations disappeared within two months, but the disease itself was characterized with the periods of exarcerbation and remission.
  
  
  CONCLUSIONS
  Acrodermatitis Enteropathica is a rare hereditary autosomal recessive disease. Mandatory clinical manifestations are: skin changes, chronic diarrhoea and alopecia. Treatment with zinc is obligatory for the life time.
authors.affiliation: Paediatrics Clinic, University Clinic Centre of Kosovo, Prishtina, Kosovo. mehmedaliazemi@hotmail.com
authors.forename: Mehmedali
authors.initials: M
authors.lastname: Azemi
authors.forename: Majlinda
authors.initials: M
authors.lastname: Berisha
authors.forename: Selim
authors.initials: S
authors.lastname: Kolgeci
authors.forename: Muharrem
authors.initials: M
authors.lastname: Avdiu
authors.forename: Teuta
authors.initials: T
authors.lastname: Hoxha-Kamberi
authors.forename: Afërdita
authors.initials: A
authors.lastname: Daka
mesh_terms: D000169:Acrodermatitis / Q000175:diagnosis* / Q000473:pathology; D002675:Child, Preschool; D006801:Humans; D008297:Male; D015032:Zinc / Q000172:deficiency
chemical_list: D015032:Zinc