title: Combining diffuse optical tomography and spectroscopy to detect and characterize lesions in two-layered tissues.
abstract: We combine diffuse optical tomography for detecting and localizing an inhomogeneity in a two-layered tissue and diffuse optical spectroscopy (DOS) for characterizing the spectrum of that inhomogeneity. For detecting and localizing an inhomogeneity, we reduce the number of unknowns substantially by seeking only the location and size of the inhomogeneity. Then, we seek to recover an unknown specific tumor component of that inhomogeneity from spectral data. In doing so, we develop a method for distinguishing between healthy and tumorous lesions. We demonstrate the utility of this theory with numerical simulations.
authors.affiliation: Gregorio Millán Institute, Universidad Carlos III de Madrid, Leganés, Spain. pgonzale@ing.uc3m.es
authors.forename: Pedro
authors.initials: P
authors.lastname: González-Rodríguez
authors.forename: Diego
authors.initials: D
authors.lastname: Alvarez
authors.forename: Arnold D
authors.initials: AD
authors.lastname: Kim
authors.forename: Miguel
authors.initials: M
authors.lastname: Moscoso
mesh_terms: D000042:Absorption; D014408:Biomarkers, Tumor / Q000378:metabolism; D008954:Models, Biological; D009369:Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology*; D013057:Spectrum Analysis / Q000379:methods*; D041622:Tomography, Optical / Q000379:methods*
chemical_list: D014408:Biomarkers, Tumor