title: Trehalose glycolipids--synthesis and biological activities.
abstract: A variety of trehalose glycolipids have been isolated from natural sources, and several of these glycolipids exhibit important biological properties. These molecules also represent challenging synthetic targets due to their highly amphiphilic character, their large number of functional groups and additional chiral centres. This review highlights some of the recent advances made in the synthesis of trehalose glycolipids, and their associated biological activities.
authors.affiliation: School of Chemical and Physical Sciences, Victoria University of Wellington, PO Box 600, Wellington, New Zealand.
authors.forename: Ashna A
authors.initials: AA
authors.lastname: Khan
authors.forename: Bridget L
authors.initials: BL
authors.lastname: Stocker
authors.forename: Mattie S M
authors.initials: MS
authors.lastname: Timmer
mesh_terms: D000818:Animals; D001419:Bacteria; D017173:Caenorhabditis elegans; D002236:Carbohydrate Conformation; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D016207:Cytokines / Q000096:biosynthesis; D004952:Esters; D006017:Glycolipids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism; D009569:Nitric Oxide / Q000096:biosynthesis; D013501:Surface-Active Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014199:Trehalose / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D016207:Cytokines; D004952:Esters; D006017:Glycolipids; D013501:Surface-Active Agents; C011117:sulfoglycolipids; D009569:Nitric Oxide; D014199:Trehalose