title: Treating depression in coronary artery disease and chronic heart failure: what's new in using selective serotonin re-uptake inhibitors?
abstract: Depression is a common co-morbidity in patients with cardiovascular diseases such as chronic coronary artery disease, acute coronary syndromes, post by-pass surgery and chronic heart failure. The presence of depression is independently associated with a decline in health status and an increase in the risk of hospitalization and death for patients with coronary artery disease or congestive heart failure. Novel treatment modalities such as selective serotonin re-uptake inhibitors (SSRIs) may improve depressive symptoms and prognosis of post-myocardial infarction and heart failure patients interacting with the common pathophysiological mechanisms of depression and cardiovascular disease. This review summarizes current experimental and clinical evidence regarding the effects of SSRIs on platelet functions, immune and neurohormonal activation, and cardiac rhythm disturbances in patients with cardiovascular disease.
authors.affiliation: 2nd Department of Cardiology, "Attikon" University Hospital of Athens, Athens, Greece. ioannispalios@hotmail.com
authors.forename: Ioannis
authors.initials: I
authors.lastname: Paraskevaidis
authors.forename: John
authors.initials: J
authors.lastname: Palios
authors.forename: John
authors.initials: J
authors.lastname: Parissis
authors.forename: Gerasimos
authors.initials: G
authors.lastname: Filippatos
authors.forename: Maria
authors.initials: M
authors.lastname: Anastasiou-Nana
mesh_terms: D001792:Blood Platelets / Q000187:drug effects; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D003324:Coronary Artery Disease / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology / Q000523:psychology*; D003863:Depression / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology / Q000523:psychology; D004347:Drug Interactions; D004730:Endothelium, Vascular / Q000187:drug effects; D006333:Heart Failure / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology / Q000523:psychology*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*
chemical_list: D017367:Selective Serotonin Reuptake Inhibitors