title: Photosensitizer and vancomycin-conjugated novel multifunctional magnetic particles as photoinactivation agents for selective killing of pathogenic bacteria.
abstract: Novel multifunctional magnetic particles (MMPs) conjugated with photosensitizer and vancomycin were fabricated by surface modification of Fe(3)O(4) particles. The capacities to target, capture and inactivate pathogenic bacteria and good biocompatibility suggest that the MMPs have great potentials as photodynamic inactivation agents for serious bacterial contamination.
authors.affiliation: Photon Applied Functional Molecule Research Laboratory, Department of Chemistry, Yonsei University, Seoul 120-749, Republic of Korea.
authors.forename: Kyong-Hoon
authors.initials: KH
authors.lastname: Choi
authors.forename: Hye-Jin
authors.initials: HJ
authors.lastname: Lee
authors.forename: Bong Joo
authors.initials: BJ
authors.lastname: Park
authors.forename: Kang-Kyun
authors.initials: KK
authors.lastname: Wang
authors.forename: Eon Pil
authors.initials: EP
authors.lastname: Shin
authors.forename: Jong-Chul
authors.initials: JC
authors.lastname: Park
authors.forename: Young Keun
authors.initials: YK
authors.lastname: Kim
authors.forename: Min-Kyu
authors.initials: MK
authors.lastname: Oh
authors.forename: Yong-Rok
authors.initials: YR
authors.lastname: Kim
mesh_terms: D000818:Animals; D001419:Bacteria / Q000187:drug effects*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D052203:Ferrosoferric Oxide / Q000737:chemistry; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D058185:Magnetite Nanoparticles / Q000737:chemistry / Q000382:microbiology*; D051379:Mice; D017319:Photosensitizing Agents / Q000737:chemistry* / Q000494:pharmacology*; D013499:Surface Properties; D014640:Vancomycin / Q000737:chemistry*
chemical_list: D058185:Magnetite Nanoparticles; D017319:Photosensitizing Agents; D014640:Vancomycin; D052203:Ferrosoferric Oxide