title: Impact of tacrolimus on bone metabolism after kidney transplantation.
abstract: Bone disease is a common clinical problem after kidney transplantation. To date, studies investigating the effects of tacrolimus (TAC) on bone metabolism in vivo or vitro yielded conflicting data. This study was carried out to discuss the relationship between TAC blood concentrations and bone metabolism status in kidney transplant recipients. 72 kidney recipients whose time since transplantation more than 5 months (5-51 months) were divided into two groups by the TAC blood concentrations, high TAC group (TAC≥6 ng/mL) and low TAC group(TAC<6 ng/mL), respectively. Bone mineral density (BMD) of lumbar vertebrae L1-L4 and neck of the femur and allied biochemical markers (TRAP-5b, B-ALP, 25-(OH)D, PTH, beta-CrossLaps, N-MID Osteocalcin, Ca, PO4) were measured simultaneously. Our results showed that 27.78% of our patients had bone loss and the loss rates were statistical different between the high TAC group and low TAC group in kidney recipients (45.5% vs 20.0%, P=0.026). Correlation analysis showed that TAC concentrations were positively correlated with tartrate-resistant acid phosphatase-5b (TRAP-5b) in male recipients (r=0.287, P<0.05). In conclusion, kidney transplant recipients with high TAC blood concentrations are at risk of bone loss, and TAC may cause bone disorders involved in accelerated bone resorption.
authors.affiliation: Department of Clinical Immunological Laboratory, West China Hospital, Sichuan University, Chengdu, PR China.
authors.forename: Limei
authors.initials: L
authors.lastname: Luo
authors.forename: Yunying
authors.initials: Y
authors.lastname: Shi
authors.forename: Yangjuan
authors.initials: Y
authors.lastname: Bai
authors.forename: Yuangao
authors.initials: Y
authors.lastname: Zou
authors.forename: Bei
authors.initials: B
authors.lastname: Cai
authors.forename: Ye
authors.initials: Y
authors.lastname: Tao
authors.forename: Tao
authors.initials: T
authors.lastname: Lin
authors.forename: Lanlan
authors.initials: L
authors.lastname: Wang
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D015415:Biomarkers / Q000097:blood; D015519:Bone Density / Q000187:drug effects*; D001862:Bone Resorption / Q000139:chemically induced / Q000378:metabolism; D003430:Cross-Sectional Studies; D005260:Female; D005272:Femur Neck / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D007677:Kidney Function Tests; D016030:Kidney Transplantation; D008111:Liver Function Tests; D008159:Lumbar Vertebrae / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D012737:Sex Factors; D016559:Tacrolimus / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use
chemical_list: D015415:Biomarkers; D007166:Immunosuppressive Agents; D016559:Tacrolimus