title: Comparative study of the expression of ATF-3 and ATF-4 genes in vessels involved into atherosclerosis process and in psoriatic skin.
abstract: Expression of ATF-3 and ATF-4 genes was examined quantitatively by real-time PCR and changes in the expression of these genes in atherosclerotic lesions and in psoriatic skin were demonstrated. It was found that concomitant pathologies do not affect the expression of these genes. Opposite changes in the expression of ATF-3 and ATF-4 genes in atherosclerotic and psoriatic samples were revealed and a hypothesis was put forward that this parameter could be a criterion of pathological process in both diseases.
authors.affiliation: N. I. Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia. sobolev_vl@mail.ru
authors.forename: V V
authors.initials: VV
authors.lastname: Sobolev
authors.forename: N L
authors.initials: NL
authors.lastname: Starodubtseva
authors.forename: A L
authors.initials: AL
authors.lastname: Piruzyan
authors.forename: M T
authors.initials: MT
authors.lastname: Minnibaev
authors.forename: M E
authors.initials: ME
authors.lastname: Sautin
authors.forename: V P
authors.initials: VP
authors.lastname: Tumanov
authors.forename: S A
authors.initials: SA
authors.lastname: Bruskin
mesh_terms: D051700:Activating Transcription Factor 3 / Q000235:genetics*; D051701:Activating Transcription Factor 4 / Q000235:genetics*; D050197:Atherosclerosis / Q000235:genetics*; D006801:Humans; D066298:In Vitro Techniques; D011565:Psoriasis / Q000235:genetics*; D060888:Real-Time Polymerase Chain Reaction; D012867:Skin / Q000378:metabolism*
chemical_list: C490449:ATF3 protein, human; C497109:ATF4 protein, human; D051700:Activating Transcription Factor 3; D051701:Activating Transcription Factor 4