title: Prognostic value of matrix metalloproteinase 9 expression in patients with non-small cell lung cancer.
abstract: BACKGROUND
  The role of matrix metalloproteinase 9 (MMP-9) expression in non-small cell lung cancer (NSCLC) remains controversial. We performed a systematic review of the literature with meta-analysis.
  
  
  METHODS
  Electronic databases were used to identify published studies before December 1, 2011. Pooled hazard ratio (HR) with 95% confidence interval (95% CI) was used to estimate the strength of the association between MMP-9 expression survival of NSCLC patients. Heterogeneity and publication bias were also assessed.
  
  
  RESULTS
  The final analysis of 2029 NSCLC cases from 17 studies is presented. The combined HR of 1.84 (95% CI: 1.62-2.09) suggested that MMP-9 over-expression had a poor prognosis in patients with NSCLC. Subgroup analyses also detected significant association. Heterogeneity and publication bias was absent in current meta-analysis. Sensitivity analyses suggested that the summary statistics obtained should approximate the actual average.
  
  
  CONCLUSIONS
  High MMP-9 expression is associated with a poor prognosis in patients with NSCLC.
authors.affiliation: Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, China.
authors.forename: Wen-Jia
authors.initials: WJ
authors.lastname: Peng
authors.forename: Jun-Qing
authors.initials: JQ
authors.lastname: Zhang
authors.forename: Bing-Xiang
authors.initials: BX
authors.lastname: Wang
authors.forename: Hai-Feng
authors.initials: HF
authors.lastname: Pan
authors.forename: Man-Man
authors.initials: MM
authors.lastname: Lu
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
mesh_terms: D014408:Biomarkers, Tumor / Q000096:biosynthesis* / Q000235:genetics; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis* / Q000201:enzymology* / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000201:enzymology* / Q000235:genetics; D020780:Matrix Metalloproteinase 9 / Q000096:biosynthesis* / Q000235:genetics; D011379:Prognosis; D012680:Sensitivity and Specificity
chemical_list: D014408:Biomarkers, Tumor; D020780:Matrix Metalloproteinase 9