title: Meeting the challenge of hematologic malignancies in sub-Saharan Africa.
abstract: Cancer is a leading cause of death and disability in sub-Saharan Africa and will eclipse infectious diseases within the next several decades if current trends continue. Hematologic malignancies, including non-Hodgkin lymphoma, leukemia, Hodgkin lymphoma, and multiple myeloma, account for nearly 10% of the overall cancer burden in the region, and the incidence of non-Hodgkin lymphoma and Hodgkin lymphoma is rapidly increasing as a result of HIV. Despite an increasing burden, mechanisms for diagnosing, treating, and palliating malignant hematologic disorders are inadequate. In this review, we describe the scope of the problem, including the impact of endemic infections, such as HIV, Epstein-Barr virus, malaria, and Kaposi sarcoma-associated herpesvirus. We additionally describe current limitations in hematopathology, chemotherapy, radiotherapy, hematopoietic stem cell transplantation, and supportive care and palliation. We review contemporary treatment and outcomes of hematologic malignancies in the region and outline a clinical service and research agenda, which builds on recent global health successes combating HIV and other infectious diseases. Achieving similar progress against hematologic cancers in sub-Saharan Africa will require the sustained collaboration and advocacy of the entire global cancer community.
authors.affiliation: Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7305, USA. gopal@med.unc.edu
authors.forename: Satish
authors.initials: S
authors.lastname: Gopal
authors.forename: William A
authors.initials: WA
authors.lastname: Wood
authors.forename: Stephanie J
authors.initials: SJ
authors.lastname: Lee
authors.forename: Thomas C
authors.initials: TC
authors.lastname: Shea
authors.forename: Kikkeri N
authors.initials: KN
authors.lastname: Naresh
authors.forename: Peter N
authors.initials: PN
authors.lastname: Kazembe
authors.forename: Corey
authors.initials: C
authors.lastname: Casper
authors.forename: Peter B
authors.initials: PB
authors.lastname: Hesseling
authors.forename: Ronald T
authors.initials: RT
authors.lastname: Mitsuyasu
mesh_terms: D017954:Africa South of the Sahara; D017281:Cost of Illness; D019353:Endemic Diseases; D019337:Hematologic Neoplasms / Q000175:diagnosis / Q000191:economics / Q000453:epidemiology* / Q000469:parasitology / Q000628:therapy* / Q000821:virology; D006801:Humans; D008288:Malaria / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D014777:Virus Diseases / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy