title: Genome sequence of Staphylococcus aureus VC40, a vancomycin- and daptomycin-resistant strain, to study the genetics of development of resistance to currently applied last-resort antibiotics.
abstract: The increasing emergence of multidrug-resistant Staphylococcus aureus is a problem of global importance. Here, we report the genome of S. aureus VC40, which is resistant to the last-resort antibiotics vancomycin and daptomycin. Its genome sequence will allow insights into the mechanisms that convey full resistance to these compounds.
authors.affiliation: Institute of Medical Microbiology, Immunology and Parasitology (IMMIP), University of Bonn, Bonn, Germany. psass@uni-bonn.de
authors.forename: Peter
authors.initials: P
authors.lastname: Sass
authors.forename: Anne
authors.initials: A
authors.lastname: Berscheid
authors.forename: Andrea
authors.initials: A
authors.lastname: Jansen
authors.forename: Marion
authors.initials: M
authors.lastname: Oedenkoven
authors.forename: Christiane
authors.initials: C
authors.lastname: Szekat
authors.forename: Axel
authors.initials: A
authors.lastname: Strittmatter
authors.forename: Gerhard
authors.initials: G
authors.lastname: Gottschalk
authors.forename: Gabriele
authors.initials: G
authors.lastname: Bierbaum
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001483:Base Sequence; D017576:Daptomycin / Q000494:pharmacology*; D024901:Drug Resistance, Multiple, Bacterial / Q000235:genetics*; D015964:Gene Expression Regulation, Bacterial / Q000187:drug effects; D016680:Genome, Bacterial; D008969:Molecular Sequence Data; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics*; D014640:Vancomycin / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D014640:Vancomycin; D017576:Daptomycin