title: Enantiospecific kinking of DNA by a partially intercalating metal complex.
abstract: Opposite enantiomers of [Ru(phenanthroline)(3)](2+) affect the persistence length of DNA differently, a long speculated effect of helix kinking. Our molecular dynamics simulations confirm a substantial change of duplex secondary structure produced by wedge-intercalation of one but not the other enantiomer. This effect is exploited by several classes of DNA operative proteins.
authors.affiliation: Department of Chemical and Biological Engineering, Physical Chemistry, Chalmers University of Technology, Gothenburg, Sweden. reymer@chalmers.se norden@chalmers.se
authors.forename: Anna
authors.initials: A
authors.lastname: Reymer
authors.forename: Bengt
authors.initials: B
authors.lastname: Nordén
mesh_terms: D056831:Coordination Complexes / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D007364:Intercalating Agents / Q000737:chemistry*; D056004:Molecular Dynamics Simulation; D009690:Nucleic Acid Conformation; D010618:Phenanthrolines / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D056831:Coordination Complexes; D007364:Intercalating Agents; D010618:Phenanthrolines; D012428:Ruthenium; D004247:DNA