title: Inter-relationship of plasma markers of oxidative stress and thyroid hormones in schizophrenics.
abstract: BACKGROUND
  The relationship of oxidative stress to thyroid hormones has not been studied in the schizophrenics. The present study determined the status and interrelationship of plasma markers of oxidative stress, nitric oxide and thyroid hormones in thirty (17 males and 13 females) newly diagnosed patients with acute schizophrenia before initiation of chemotherapy. Twenty five (13 males and 12 females) mentally healthy individuals served as controls. Patients and controls with history of hard drugs (including alcohol and cigarette), pre-diagnosis medications (e.g. antiparkinsonian/antipsychotic drugs), chronic infections, liver disease and diabetes mellitus were excluded from the study. Plasma levels of total antioxidant potential (TAP), total plasma peroxides (TPP), nitric oxide (NO), malondialdehyde (MDA), thyroxine (T4), tri-iodothyronine (T3) and thyroid stimulating hormone (TSH) were determined in all participants using spectrophotometric and enzyme linked immunosorbent assay (ELISA) methods respectively. Oxidative stress index (OSI) was calculated as the percent ratio of total plasma peroxides and total antioxidant potential.
  
  
  RESULTS
  Significantly higher plasma levels of MDA (p < 0.01), TPP (p < 0.01), OSI (p < 0.01), T3 (p < 0.01) and T4 (p < 0.05) were observed in schizophrenics when compared with the controls. The mean levels of TAP, NO and TSH were significantly lower in schizophrenics (p < 0.01) when compared with the controls. The result shows that T3 values correlate significantly with MDA (p < 0.05) and TPP (p < 0.01) in schizophrenics.
  
  
  CONCLUSIONS
  Higher level of TPP may enhance thyroid hormogenesis in schizophrenics. Adjuvant antioxidant therapy may be a novel approach in the treatment of schizophrenic patients.
authors.affiliation: Department of Chemical Pathology and Immunology, College of Health Sciences, Olabisi Onabanjo University, Ago-Iwoye, Ogun State, Nigeria. akiibinumoses@yahoo.com
authors.forename: Moses O
authors.initials: MO
authors.lastname: Akiibinu
authors.forename: Omobola A
authors.initials: OA
authors.lastname: Ogundahunsi
authors.forename: Ebenezer O
authors.initials: EO
authors.lastname: Ogunyemi
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D009569:Nitric Oxide / Q000097:blood; D018384:Oxidative Stress; D010545:Peroxides / Q000097:blood; D012559:Schizophrenia / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology; D013961:Thyroid Gland / Q000378:metabolism* / Q000503:physiopathology; D013963:Thyroid Hormones / Q000097:blood*; D013972:Thyrotropin / Q000097:blood
chemical_list: D015415:Biomarkers; D010545:Peroxides; D013963:Thyroid Hormones; D009569:Nitric Oxide; D008315:Malondialdehyde; D013972:Thyrotropin