title: Light-chain deposition disease of the kidney: a case report.
abstract: A 41-year-old man was admitted for evaluation of nephrotic syndrome associated with microhematuria, hypertension, and moderate renal failure. In serum and urine samples, monoclonal IgG-lambda was detected. Bone marrow examination showed normal representation of all cell lines with normal range of plasma cells. Renal biopsy demonstrated diabetes-like nodular glomerulosclerosis. Immunofluorescence failed to demonstrate the presence of kappa or lambda light chains in the kidney. Electron microcopy showed granular electron-dense deposits along the glomerular basement membranes and in the mesangial nodules. The patient was diagnosed as having light-chain deposition disease (LCDD) without evidence of plasma cell dyscrasia. This report was designed to stress the significant challenges that remain in the diagnosis of LCDD-related glomerulopathy. The salient morphological features that help in making an accurate diagnosis are discussed.
authors.affiliation: Electron Microscopy Laboratory, Faculty of Medicine of Tunis, Tunis, Tunisia.
authors.forename: Sihem
authors.initials: S
authors.lastname: Darouich
authors.forename: Rym
authors.initials: R
authors.lastname: Goucha
authors.forename: Mohamed Habib
authors.initials: MH
authors.lastname: Jaafoura
authors.forename: Semy
authors.initials: S
authors.lastname: Zekri
authors.forename: Adel
authors.initials: A
authors.lastname: Kheder
authors.forename: Hedi Ben
authors.initials: HB
authors.lastname: Maiz
mesh_terms: D000328:Adult; D001706:Biopsy; D005455:Fluorescent Antibody Technique; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000276:immunology*; D007668:Kidney / Q000473:pathology* / Q000648:ultrastructure*; D008297:Male; D046529:Microscopy, Electron, Transmission; D009404:Nephrotic Syndrome / Q000276:immunology / Q000473:pathology*
chemical_list: D007147:Immunoglobulin Light Chains