title: Juvenile Huntington's disease presenting as difficult-to-treat seizure and the first episode of psychosis.
abstract: OBJECTIVE
  The objective was to describe a case of juvenile Huntington's disease that first presented with seizures and psychosis.
  
  
  METHODS
  A male patient with no history of epilepsy and psychiatric disorder had his first seizure at the age of 20 years, which was followed by 3 years of psychotic disorder.
  
  
  RESULTS
  Laboratory investigations were normal, and mild diffuse cortical atrophy was detected using magnetic resonance imaging. Both the seizures and psychosis were difficult to treat. Three years later, chorea and personality changes appeared. Genetic tests revealed an expanded allele with 60 CAG repeats, confirming the typical Huntington's disease characteristic.
  
  
  CONCLUSIONS
  Patients with difficult-to-treat seizures and the first episode of psychosis should be considered for the diagnosis of juvenile Huntington's disease.
authors.affiliation: Department of Psychiatry, Taichung Veterans General Hospital, Taichung City, Taiwan.
authors.forename: Yi-Ping
authors.initials: YP
authors.lastname: Chuo
authors.forename: Po-Hsun
authors.initials: PH
authors.lastname: Hou
authors.forename: Chin-Hong
authors.initials: CH
authors.lastname: Chan
authors.forename: Chih-Chien
authors.initials: CC
authors.lastname: Lin
authors.forename: Yi-Chu
authors.initials: YC
authors.lastname: Liao
mesh_terms: D003937:Diagnosis, Differential; D005820:Genetic Testing; D006801:Humans; D006816:Huntington Disease / Q000150:complications* / Q000175:diagnosis; D008297:Male; D011618:Psychotic Disorders / Q000209:etiology*; D012640:Seizures / Q000209:etiology*; D013624:Taiwan; D016896:Treatment Outcome; D055815:Young Adult