title: A wireless handheld probe with spectrally constrained evolution strategies for diffuse optical imaging of tissue.
abstract: We present a low-cost, portable, wireless diffuse optical imaging device. The handheld device is fast, portable, and can be applied to a wide range of both static and dynamic imaging applications including breast cancer, functional brain imaging, and peripheral artery disease. The continuous-wave probe has four near-infrared wavelengths and uses digital detection techniques to perform measurements at 2.3 Hz. Using a multispectral evolution algorithm for chromophore reconstruction, we can measure absolute oxygenated and deoxygenated hemoglobin concentration as well as scattering in tissue. Performance of the device is demonstrated using a series of liquid phantoms comprised of Intralipid(®), ink, and dye.
authors.affiliation: Department of Biomedical Engineering, Columbia University, New York, New York 10027, USA. mlf2129@columbia.edu
authors.forename: M L
authors.initials: ML
authors.lastname: Flexman
authors.forename: H K
authors.initials: HK
authors.lastname: Kim
authors.forename: R
authors.initials: R
authors.lastname: Stoll
authors.forename: M A
authors.initials: MA
authors.lastname: Khalil
authors.forename: C J
authors.initials: CJ
authors.lastname: Fong
authors.forename: A H
authors.initials: AH
authors.lastname: Hielscher
mesh_terms: D007091:Image Processing, Computer-Assisted; D057054:Molecular Imaging / Q000295:instrumentation*; D055620:Optical Phenomena; D019047:Phantoms, Imaging; D013997:Time Factors; D059015:Wireless Technology