title: Role of hydrogen sulfide in the regulation of cell apoptosis.
abstract: We studied the effect of a gas transmitter hydrogen sulfide (H(2)S) on the realization of apoptosis in Jurkat cells and mononuclear leukocytes from healthy donors. Treatment with H(2)S donor NaHS was accompanied by a dose-dependent intensification of cell death via apoptosis and necrosis. T-cell leukemia cells were more sensitive to H2S than mononuclear leukocytes from healthy donors. H(2)S-induced cell apoptosis was accompanied by activation of caspase-3 and caspase-9.
authors.affiliation: Siberian State Medical University, Russian Ministry of Health Care and Social Development, Tomsk, Russia.
authors.forename: N V
authors.initials: NV
authors.lastname: Ryazantseva
authors.forename: V V
authors.initials: VV
authors.lastname: Novitsky
authors.forename: E G
authors.initials: EG
authors.lastname: Starikova
authors.forename: L A
authors.initials: LA
authors.lastname: Kleptsova
authors.forename: V D
authors.initials: VD
authors.lastname: Jakushina
authors.forename: E V
authors.initials: EV
authors.lastname: Kaigorodova
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D020169:Caspases / Q000378:metabolism; D002478:Cells, Cultured; D006801:Humans; D006862:Hydrogen Sulfide / Q000378:metabolism*; D013440:Sulfides / Q000494:pharmacology*
chemical_list: D013440:Sulfides; D020169:Caspases; C025451:sodium bisulfide; D006862:Hydrogen Sulfide