title: Understanding optimal colonic cancer surgery: comparison of Japanese D3 resection and European complete mesocolic excision with central vascular ligation.
abstract: OBJECTIVE
  Over recent years, patient outcomes after colon cancer resection have not improved to the same degree as for rectal cancer. Japanese D3 resection and European complete mesocolic excision (CME) with central vascular ligation (CVL) are both based on sound oncologic principles. Expert surgeons using both techniques report impressive outcomes as compared with standard surgery. We aimed to independently compare the physical appearances and quality of specimens resected using both techniques in major institutions in Japan and Germany.
  
  
  METHODS
  A series of resections for primary colon cancer from one European and two Japanese centers were independently assessed in terms of the plane of surgery, physical characteristics, and lymph node yields.
  
  
  RESULTS
  Mesocolic plane resection rates from both series were high; however, Japanese D3 specimens were significantly shorter (162 v 324 mm, P < .001), resulting in a smaller amount of mesentery (8,309 v 17,957 mm(2), P < .001) and nodal yield (median, 18 v 32, P < .001). The distance from the high vascular tie to the bowel wall (100 v 99 mm, P = .605) was equivalent.
  
  
  CONCLUSIONS
  Both techniques showed high mesocolic plane resection rates and long distances between the high tie and the bowel wall. The extended longitudinal resection after CME with CVL increased the nodal yield but did not increase the number of tumor involved nodes. Both series were oncologically superior to recently reported series from other countries and confirm the wide variation in colonic cancer surgery and the need for further standardization and optimization following the approach undertaken in improving rectal cancer outcomes.
authors.affiliation: Leeds Institute of Molecular Medicine, Leeds, United Kingdom. n.p.west@leeds.ac.uk
authors.forename: Nicholas P
authors.initials: NP
authors.lastname: West
authors.forename: Hirotoshi
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Keiichi
authors.initials: K
authors.lastname: Takahashi
authors.forename: Aristoteles
authors.initials: A
authors.lastname: Perrakis
authors.forename: Klaus
authors.initials: K
authors.lastname: Weber
authors.forename: Werner
authors.initials: W
authors.lastname: Hohenberger
authors.forename: Kenichi
authors.initials: K
authors.lastname: Sugihara
authors.forename: Philip
authors.initials: P
authors.lastname: Quirke
mesh_terms: D000368:Aged; D003082:Colectomy / Q000379:methods*; D003110:Colonic Neoplasms / Q000098:blood supply / Q000473:pathology / Q000601:surgery*; D004210:Dissection; D005260:Female; D005858:Germany; D006801:Humans; D007564:Japan; D010535:Laparoscopy; D008026:Ligation; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology / Q000601:surgery; D008297:Male; D008646:Mesocolon / Q000098:blood supply / Q000473:pathology / Q000601:surgery*; D008875:Middle Aged; D016896:Treatment Outcome; D014656:Vascular Surgical Procedures