title: Oral lesions associated with hydroxyurea treatment.
abstract: Hydroxyurea (HU) is an antimetabolic agent commonly used in myeloproliferative disorders and hematological diseases as well as in severe psoriasis. Despite of usually be well tolerated, sometimes it can induce immunosuppression and mucocutaneous adverse effects associated with discomfort or pain. Nevertheless, oral mucosal adverse reactions are extremely uncommon and present as ulcers, tongue depapilation and dyschromia. Complete remission of adverse effects is usually observed after withdrawal of the medication. The aim of this paper is to report two patients with oral lesions related to HU treatment. T0 he patients were adequately managed by changing hydroxyurea with imatinib mesilate. Oral lesions are rare complications of long-term hydroxyurea treatment and may be an indication of stopping therapy and substitution with imatinib mesilate.
authors.affiliation: Department of Oral Diagnosis, Piracicaba Dental School, Campinas State University (UNICAMP), Sao Paulo, Brazil.
authors.forename: Regina
authors.initials: R
authors.lastname: Mendonça
authors.forename: Luiz Alcino
authors.initials: LA
authors.lastname: Gueiros
authors.forename: Kátia
authors.initials: K
authors.lastname: Capellaro
authors.forename: Vitória Régia Pereira
authors.initials: VR
authors.lastname: Pinheiro
authors.forename: Márcio Ajudarte
authors.initials: MA
authors.lastname: Lopes
mesh_terms: D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001549:Benzamides; D005882:Gingival Diseases / Q000139:chemically induced; D006801:Humans; D006918:Hydroxyurea / Q000009:adverse effects*; D000068877:Imatinib Mesylate; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy; D008047:Lip Diseases / Q000139:chemically induced; D008297:Male; D009059:Mouth Diseases / Q000139:chemically induced*; D009060:Mouth Floor / Q000187:drug effects; D009061:Mouth Mucosa / Q000187:drug effects; D019226:Oral Ulcer / Q000139:chemically induced; D010879:Piperazines / Q000627:therapeutic use; D011743:Pyrimidines / Q000627:therapeutic use; D014060:Tongue Diseases / Q000139:chemically induced
chemical_list: D000970:Antineoplastic Agents; D001549:Benzamides; D010879:Piperazines; D011743:Pyrimidines; D000068877:Imatinib Mesylate; D006918:Hydroxyurea