title: Dental enamel defects in Italian children with cystic fibrosis: an observational study.
abstract: OBJECTIVE
  The relationship between cystic fibrosis (CF) and caries experience has already been explored, but relatively little information is available on dental enamel defects prevalence among children affected by cystic fibrosis. The aim of this study was to investigate this issue in deciduous and permanent teeth of children with CF resident in southern Italy.
  
  
  METHODS
  This cross sectional observational study was undertaken between October 2009 and March 2010.
  
  
  METHODS
  88 CF patients and 101 healthy age-matched participated in this study.
  
  
  METHODS
  The prevalence of dental enamel defects was calculated using a modified Developmental Defects of Enamel (DDE) index. The comparison of dental enamel defects prevalence among groups was carried out using regression binary logistic analysis.
  
  
  RESULTS
  In the CF subjects there was a higher prevalence (56%) of enamel defects in comparison to the healthy group (22%). The most prevalent enamel defect was hypoplasia with loss of enamel (23% of CF patients vs 1 1/2% of control group) in permanent teeth.
  
  
  CONCLUSIONS
  This study confirms that children with cystic fibrosis are at increased risk of developing hypoplastic defects on their permanent teeth.
authors.affiliation: Department of Paediatric Dentistry, University of Naples Federico II, Naples, Italy. gianmariafabrizio@yahoo.it
authors.forename: G F
authors.initials: GF
authors.lastname: Ferrazzano
authors.forename: G
authors.initials: G
authors.lastname: Sangianantoni
authors.forename: T
authors.initials: T
authors.lastname: Cantile
authors.forename: I
authors.initials: I
authors.lastname: Amato
authors.forename: S
authors.initials: S
authors.lastname: Orlando
authors.forename: A
authors.initials: A
authors.lastname: Ingenito
mesh_terms: D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D003550:Cystic Fibrosis / Q000453:epidemiology; D003743:Dental Enamel / Q000002:abnormalities*; D003744:Dental Enamel Hypoplasia / Q000453:epidemiology; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D015995:Prevalence; D014075:Tooth Discoloration / Q000453:epidemiology