title: The interaction of the ubiquitin 50-59 fragment with copper(II) ions.
abstract: In the present study, the coordination abilities of ubiquitin 50-59 fragment and its analog containing βAsp residue are discussed. The analysis is provided based on the results of potentiometric and spectroscopic measurements supported by quantum-chemical calculations. Interesting differences in the coordination of the metal cation by modified and unmodified peptides are reported. Moreover, in order to further characterize experimentally observed species, we performed quantum-chemical calculations for structures mimicking ubiquitin 50-59 fragment as a step toward a better understanding of structural and energetical aspects related to the coordination abilities of ubiquitin.
authors.affiliation: Department of Inorganic Chemistry, Wrocław Medical University, Szewska 38, 50-139 Wrocław, Poland.
authors.forename: Hanna
authors.initials: H
authors.lastname: Czapor-Irzabek
authors.forename: Marek
authors.initials: M
authors.lastname: Cebrat
authors.forename: Żaneta
authors.initials: Ż
authors.lastname: Czyżnikowska
authors.forename: Justyna
authors.initials: J
authors.lastname: Brasuń
mesh_terms: D003300:Copper / Q000737:chemistry*; D006801:Humans; D008956:Models, Chemical; D009842:Oligopeptides / Q000737:chemistry*; D025801:Ubiquitin / Q000737:chemistry*
chemical_list: D009842:Oligopeptides; D025801:Ubiquitin; D003300:Copper