title: PARP1 parylation promotes silent locus transmission in the nucleolus: the suspicion confirmed.
abstract: Parylation modulates various processes, including transcription. In this issue of Molecular Cell, Guetg et al. (2012) show that, in the nucleolus, PARP1-mediated parylation of TIP5 promotes the silencing of rDNA chromatin during replication, uncovering the mechanism by which PARP1 ensures that silent rDNA regions are properly inherited.
authors.affiliation: Centre de recherche du CHUQ-Pavillon CHUL, Cancer Axis, Québec, Canada.
authors.forename: Maxim
authors.initials: M
authors.lastname: Isabelle
authors.forename: Imed-Eddine
authors.initials: IE
authors.lastname: Gallouzi
authors.forename: Guy G
authors.initials: GG
authors.lastname: Poirier