title: Synthesis of oxovanadium complexes and their apoptosis-inducing activity in leukemia cells.
abstract: Vanadium complexes with different ligands were synthesized and evaluated for antiproliferative activity on U937 cells. The alkyl chain length of the ligands affected the antiproliferative activity, and two complexes-3b and 4-exhibited strong activities with IC(50) values of 6.02 and 3.90 μM respectively. Annexin V staining and DNA ladder formation indicated that these complexes induced apoptosis in U937 cells.
authors.affiliation: Department of Materials and Life Science, Faculty of Science and Technology, Seikei University, 3–3–1 Kichijojikitamachi, Musashino, Tokyo.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: Shinya
authors.initials: S
authors.lastname: Watanabe
authors.forename: Yuriko
authors.initials: Y
authors.lastname: Matsumura
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Tokuoka
authors.forename: Akihiro
authors.initials: A
authors.lastname: Yokoyama
mesh_terms: D017209:Apoptosis / Q000187:drug effects*; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D053938:DNA Fragmentation / Q000187:drug effects; D006801:Humans; D007938:Leukemia / Q000473:pathology; D020298:U937 Cells; D014639:Vanadium / Q000737:chemistry*
chemical_list: D056831:Coordination Complexes; D014639:Vanadium