title: Glucuronoxylomannan facilitates generation of chondrocytes from bone marrow-derived mononuclear cells.
abstract: Chondrocyte generation is an important process in cartilage and bone repair. Factors facilitating the induction of chondrocyte need to be further investigated. The present study aims to investigate the role of glucuronoxylomannan (Gxm) in the generation of chondrocytes. Human bone marrow cells were prepared using to generate the chondrocytes in the presence of Gxm. The results showed that Gxm has the capacity to facilitate the generation of chondrocytes in which transforming growth factor (TGF)-β played a critical role. The Bmmc-derived CD14+ cells were the major source of TGF-β in the culture. The present study indicates that Gxm is a potential drug candidate to be used in the generation of chondrocyte.
authors.affiliation: Department of Orthopaedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China. zagyi0356@126.com
authors.forename: Aiguo
authors.initials: A
authors.lastname: Zhou
authors.forename: Hong
authors.initials: H
authors.lastname: An
authors.forename: Dianming
authors.initials: D
authors.lastname: Jiang
authors.forename: Jian
authors.initials: J
authors.lastname: Zhang
mesh_terms: D053674:Aggrecans / Q000378:metabolism; D001854:Bone Marrow Cells / Q000187:drug effects*; D018929:Cell Culture Techniques; D002454:Cell Differentiation / Q000187:drug effects*; D019902:Chondrocytes / Q000166:cytology* / Q000378:metabolism; D024043:Collagen Type II / Q000378:metabolism; D003455:Cryptococcus neoformans; D006801:Humans; D018950:Lipopolysaccharide Receptors / Q000378:metabolism; D011134:Polysaccharides / Q000494:pharmacology*; D055758:SOX9 Transcription Factor / Q000378:metabolism; D016212:Transforming Growth Factor beta / Q000378:metabolism
chemical_list: D053674:Aggrecans; D024043:Collagen Type II; D018950:Lipopolysaccharide Receptors; D011134:Polysaccharides; D055758:SOX9 Transcription Factor; C527932:SOX9 protein, human; D016212:Transforming Growth Factor beta; C027478:glucuronoxylomannan