title: A double-blind randomized study comparing the efficacy and safety of a composite vs a conventional intravenous fat emulsion in postsurgical gastrointestinal tumor patients.
abstract: BACKGROUND
  Composite intravenous fat emulsion, a fat emulsion composed of soybean oil, medium-chain triglycerides (MCT), olive oil, and fish oil, was evaluated for metabolic efficacy, immune modulation, clinical efficacy, safety, and tolerance in surgical gastrointestinal (GI) tumor patients.
  
  
  METHODS
  In a prospective, randomized, double-blind study, 40 patients were randomized after elective digestive surgery to receive isonitrogenous, isoenergetic parenteral nutrition for 5 days postoperatively with either composite 20% IVFE (composed of soybean, MCT, olive, and fish oils) or a conventional long-chain triglyceride (LCT)/MCT 20% IVFE (LCT/MCT IVFE); IVFE was dosed at 1-2 g/kg body weight. Safety and efficacy parameters were assessed on operation day (day 0) and at the end of study (day 6). Adverse events were documented daily and clinical outcomes were recorded and compared between the groups.
  
  
  RESULTS
  Metabolic parameters, laboratory parameters, proinflammatory cytokine levels, adverse events, and clinical outcomes did not differ between the 2 groups, with the exception that postoperative low-density lipoprotein levels decreased significantly in the composite IVFE group (93.2 ± 24.3 vs 110.5 ± 26.4 mg/dL, P = .038).
  
  
  CONCLUSIONS
  composite IVFE was comparable with conventional LCT/MCT IVFE in efficacy, safety, tolerance, and clinical outcomes in surgical GI tumor patients.
authors.affiliation: Division of Gastrointestinal and General Surgery, Department of Surgery, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors.forename: Cheng-Jen
authors.initials: CJ
authors.lastname: Ma
authors.forename: Li-Chu
authors.initials: LC
authors.lastname: Sun
authors.forename: Fang-Ming
authors.initials: FM
authors.lastname: Chen
authors.forename: Chien-Yu
authors.initials: CY
authors.lastname: Lu
authors.forename: Ying-Ling
authors.initials: YL
authors.lastname: Shih
authors.forename: Hsiang-Lin
authors.initials: HL
authors.lastname: Tsai
authors.forename: Jui-Fen
authors.initials: JF
authors.lastname: Chuang
authors.forename: Jaw-Yuan
authors.initials: JY
authors.lastname: Wang
mesh_terms: D000368:Aged; D003110:Colonic Neoplasms / Q000601:surgery; D004311:Double-Blind Method; D005217:Fat Emulsions, Intravenous / Q000009:adverse effects* / Q000737:chemistry / Q000627:therapeutic use*; D005395:Fish Oils; D005770:Gastrointestinal Neoplasms / Q000601:surgery*; D006801:Humans; D008875:Middle Aged; D000069463:Olive Oil; D010288:Parenteral Nutrition; D010938:Plant Oils; D011182:Postoperative Care / Q000379:methods*; D011446:Prospective Studies; D013024:Soybean Oil; D013274:Stomach Neoplasms; D014280:Triglycerides
chemical_list: D005217:Fat Emulsions, Intravenous; D005395:Fish Oils; D000069463:Olive Oil; D010938:Plant Oils; D014280:Triglycerides; D013024:Soybean Oil