title: Our capricious vessels: The influence of stent design and vessel geometry on the mechanics of intracranial aneurysm stent deployment.
abstract: There is a growing interest in virtual tools to assist clinicians in evaluating different procedures and devices for endovascular treatment. In the present study we use finite element analysis to investigate the influence of stent design and vessel geometry for stent assisted coiling of intracranial aneurysms. Nine virtual stenting procedures were performed: three nitinol stent designs ((i) an open cell stent resembling the Neuroform, (ii) a generic stiff and (iii) a more flexible closed cell design), were deployed in three patient-specific cerebral aneurysmatic vessels. We investigated the percentage of strut area covering the aneurysm neck, the straightening induced on the cerebrovasculature by the stent placement (quantified by the reduction in tortuosity), and stent apposition to the wall (quantified as the percentage of struts within 0.2mm of the vessel). The results suggest that the open cell design better covers the aneurysm neck (11.0±1.1%) compared to both the stiff (7.8±1.6%) and flexible (8.7±1.6%) closed cell stents, and induces less straightening of the vessel (-5.1±1.6% vs. -42.9±9.8% and -26.9±11.9% ). The open cell design has, however, less struts apposing well to the vessel wall (56.0±6.4%) compared to the flexible (73.4±4.6%) and stiff (70.4±5.1%) closed cell design. With the presented study, we hope to contribute to and improve aneurysm treatment, using a novel patient specific environment as a possible pre-operative tool to evaluate mechanical stent behavior in different vascular geometries.
authors.affiliation: Institute Biomedical Technology (IBiTech), Ghent University, De Pintelaan 185-Block B, BE-9000 Ghent, Belgium.
authors.forename: S
authors.initials: S
authors.lastname: De Bock
authors.forename: F
authors.initials: F
authors.lastname: Iannaccone
authors.forename: G
authors.initials: G
authors.lastname: De Santis
authors.forename: M
authors.initials: M
authors.lastname: De Beule
authors.forename: P
authors.initials: P
authors.lastname: Mortier
authors.forename: B
authors.initials: B
authors.lastname: Verhegghe
authors.forename: P
authors.initials: P
authors.lastname: Segers
mesh_terms: D001783:Blood Flow Velocity; D001794:Blood Pressure; D001807:Blood Vessel Prosthesis; D002536:Cerebral Arteries / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery*; D002560:Cerebrovascular Circulation; D003198:Computer Simulation; D017076:Computer-Aided Design; D019544:Equipment Failure Analysis; D006801:Humans; D002532:Intracranial Aneurysm / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery*; D008955:Models, Cardiovascular; D011474:Prosthesis Design; D015607:Stents; D016896:Treatment Outcome