title: Development of a novel composite material with carbon nanotubes assisted by self-assembled peptides designed in conjunction with β-sheet formation.
abstract: A novel composite material is developed with single-walled carbon nanotubes (SWCNTs) and artificially designed peptides, and its chemical and physicochemical characteristics are evaluated with an aim toward biomedical application. The peptides were designed to form a β-sheet structure that would be suitable for wrapping SWCNTs. The complex of SWCNTs and peptide (SWCNT-peptide) showed good dispersibility in aqueous media and was considerably stable even in the absence of an excess amount of peptide in the media. The formation of SWCNT-peptide was confirmed by its performance in water, atomic force microscopy and transmission electron microscopy observation, and molecular modeling. The possibility of introducing various functions to SWCNT-peptide was also demonstrated by several methods, such as introduction of special amino acids, chemical modification, and additional complex formation based on electrostatic interaction. These results suggest the potential of the SWCNT-peptide complex as a molecular platform on which a desirable structure and/or function can be constructed for biomedical and industrial application.
authors.affiliation: Institute for Integrated Cell-Material Sciences (iCeMS), Kyoto University, Kyoto 606-8501, Japan.
authors.forename: Yasuhiko
authors.initials: Y
authors.lastname: Hashida
authors.forename: Tomokazu
authors.initials: T
authors.lastname: Umeyama
authors.forename: Junya
authors.initials: J
authors.lastname: Mihara
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Imahori
authors.forename: Masahiko
authors.initials: M
authors.lastname: Tsujimoto
authors.forename: Seiji
authors.initials: S
authors.lastname: Isoda
authors.forename: Mikio
authors.initials: M
authors.lastname: Takano
authors.forename: Mitsuru
authors.initials: M
authors.lastname: Hashida
mesh_terms: D002942:Circular Dichroism; D018625:Microscopy, Atomic Force; D046529:Microscopy, Electron, Transmission; D008958:Models, Molecular; D053761:Nanocomposites; D036103:Nanotechnology / Q000379:methods; D037742:Nanotubes, Carbon / Q000737:chemistry*; D010455:Peptides / Q000737:chemistry*; D011485:Protein Binding; D017433:Protein Structure, Secondary; D055672:Static Electricity; D013329:Structure-Activity Relationship; D013499:Surface Properties
chemical_list: D037742:Nanotubes, Carbon; D010455:Peptides