title: Co-infection with Toxoplasma gondii and Clostridium perfringens in a postpartum woman with uterine gas gangrene: a case report.
abstract: Toxoplasmosis is a protozoan infection caused by Toxoplasma gondii. We report a case of Toxoplasma gondii and Clostridium perfringens co-infection complicating uterine gas gangrene following a term pregnancy. The histological examination of the necrotic uterine tissues and uterine swab cultures obtained at laparotomy revealed T. gondii and C. perfringens, respectively. Treatment was administered with bactericidal activity against both pathogens and the patient had an uneventful post-operative recovery. Although there have been some cases that have documented an association between toxoplasmosis and non-uterine C. perfringens infection, such a relationship has not been established. It is of interest to determine if the presence of both organisms can explain the severe myonecrosis that occurs in some cases of uterine gas gangrene.
authors.affiliation: Department of Obstetrics and Gynecology, College of Medicine, Qassim University, Buraidah, Saudi Arabia. m_sammani@yahoo.com
authors.forename: Mohamed Alkhatim
authors.initials: MA
authors.lastname: Alsammani
authors.forename: Salah Roshdy
authors.initials: SR
authors.lastname: Ahmed
authors.forename: Muneera A
authors.initials: MA
authors.lastname: Alsheeha
authors.forename: Zaheera
authors.initials: Z
authors.lastname: Saadia
authors.forename: Somia A
authors.initials: SA
authors.lastname: Khairi
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003016:Clostridium perfringens / Q000302:isolation & purification*; D003049:Coccidiostats / Q000627:therapeutic use; D060085:Coinfection / Q000188:drug therapy* / Q000382:microbiology / Q000469:parasitology; D004359:Drug Therapy, Combination; D005260:Female; D005738:Gas Gangrene / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D006801:Humans; D009336:Necrosis; D011644:Puerperal Disorders / Q000188:drug therapy* / Q000382:microbiology / Q000469:parasitology / Q000473:pathology; D060737:Reproductive Tract Infections / Q000188:drug therapy / Q000382:microbiology / Q000469:parasitology; D014122:Toxoplasma / Q000302:isolation & purification*; D014123:Toxoplasmosis / Q000188:drug therapy* / Q000469:parasitology / Q000473:pathology; D016896:Treatment Outcome; D014599:Uterus / Q000382:microbiology / Q000469:parasitology / Q000473:pathology*; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents; D003049:Coccidiostats