title: [Extensive mesenteric ischemia related to naratriptan overuse associated with grapefruit juice absorption].
abstract: We reported the case of a 61-year-old woman, who has been hospitalized in ICU because of an extensive mesenteric ischaemia, involving the small bowel, secondary to a naratriptan overuse. This mesenteric ischaemia was complicated by multiple organ failure and was responsible for extensive small bowel resection and left colectomy. A concomitant abundant absorption of grapefruit juice, a well-known P450 inhibitor, may have enhanced this naratriptan toxicity. This case underscore that an abdominal pain occurring in the context of headache treatment may be related to a mesenteric ischaemia.
authors.affiliation: Pôle d'anesthésie-réanimation, université d'Angers, CHU d'Angers, 4, rue Larrey, 49000 Angers, France.
authors.forename: S
authors.initials: S
authors.lastname: Gergaud
authors.forename: E
authors.initials: E
authors.lastname: Lermite
authors.forename: F
authors.initials: F
authors.lastname: Butel
authors.forename: C
authors.initials: C
authors.lastname: Soltner
authors.forename: S
authors.initials: S
authors.lastname: Lasocki
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D032083:Citrus paradisi; D003082:Colectomy; D004562:Electrocardiography; D005260:Female; D018565:Food-Drug Interactions; D006801:Humans; D007422:Intestines / Q000601:surgery; D007511:Ischemia / Q000139:chemically induced* / Q000601:surgery; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000150:complications; D010880:Piperidines / Q000009:adverse effects*; D018490:Serotonin Agents / Q000009:adverse effects*; D012769:Shock / Q000188:drug therapy / Q000209:etiology; D013152:Splanchnic Circulation / Q000502:physiology*; D014363:Tryptamines / Q000009:adverse effects*
chemical_list: D010880:Piperidines; D018490:Serotonin Agents; D014363:Tryptamines; C106783:naratriptan