title: The PSCA polymorphisms derived from genome-wide association study are associated with risk of gastric cancer: a meta-analysis.
abstract: OBJECTIVE
  Prostate stem cell antigen (PSCA) is a glycosylphosphatidylinositol-anchored 123-aa protein related to the cell-proliferation inhibition and/or cell-death induction activity. Many studies had reported the role of PSCA rs2294008 C > T and rs2976392 G > A polymorphisms on gastric cancer risk.
  
  
  METHODS
  To investigate a more precise estimation of the relationships, we performed a meta-analysis on 9 case-control studies included 10,746 cases and 9,158 controls. Odds ratios (ORs) and 95 % confidence intervals (CIs) were used to assess the strength of the association.
  
  
  RESULTS
  For PSCA rs2294008 C > T polymorphism, there was a significantly increased risk of gastric cancer in all genetic models (TT/TC vs. CC: OR = 1.61, 95 % CI = 1.35-1.91; TT vs.
  OR = 1.33, 95 % CI = 1.24-1.42). Similar results were also observed for PSCA rs2976392 G > A polymorphism (AA/AG vs. GG: OR = 1.69, 95 % CI = 1.24-2.31; AA vs.
  OR = 1.36, 95 % CI = 1.24-1.50). In the stratified analysis by ethnicity of rs2294008, an increased gastric cancer risk was found in both Asians (TT vs.
  OR = 1.31, 95 % CI = 1.22-1.42) and Europeans (TT/TC vs. CC: OR = 1.42, 95 % CI = 1.18-1.71). Furthermore, when stratified by clinicopathologic characteristics of tumor location and histology, a higher risk on non-cardia compared with cardia gastric cancer (TT vs.
  OR = 1.43, 95 % CI = 1.12-1.83) as same as diffused compared with intestinal gastric cancer (TT vs.
  OR = 1.29, 95 % CI = 1.13-1.49) was observed.
  
  
  CONCLUSIONS
  These findings supported that PSCA rs2294008 C > T and rs2976392 G > A polymorphisms may contribute to the susceptibility to gastric cancer, particular in non-cardia or diffused gastric cancer.
authors.affiliation: The Key Laboratory of Modern Toxicology of Ministry of Education, Department of Molecular and Genetic Toxicology, School of Public Health, Nanjing Medical University, Nanjing 210029, China.
authors.forename: Danni
authors.initials: D
authors.lastname: Shi
authors.forename: Shizhi
authors.initials: S
authors.lastname: Wang
authors.forename: Dongying
authors.initials: D
authors.lastname: Gu
authors.forename: Dongmei
authors.initials: D
authors.lastname: Wu
authors.forename: Meilin
authors.initials: M
authors.lastname: Wang
authors.forename: Haiyan
authors.initials: H
authors.lastname: Chu
authors.forename: Na
authors.initials: N
authors.lastname: Tong
authors.forename: Lan
authors.initials: L
authors.lastname: Ma
authors.forename: Dongyan
authors.initials: D
authors.lastname: Zhong
authors.forename: Zhengdong
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000483:Alleles; D000951:Antigens, Neoplasm / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D058851:GPI-Linked Proteins / Q000235:genetics; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000208:ethnology / Q000235:genetics; D055106:Genome-Wide Association Study; D005838:Genotype; D006801:Humans; D009363:Neoplasm Proteins / Q000235:genetics*; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000208:ethnology / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D000951:Antigens, Neoplasm; D058851:GPI-Linked Proteins; D009363:Neoplasm Proteins; C110843:PSCA protein, human