title: [Immune system disorders and their correction in critically ill patients with toxic and hypoxic encephalopathy].
abstract: In this article there are materials, which were received in the process of treatment of 69 patients with azaleptin (leponeks) acute severe poisonings. The immunologic research has shown that the first phase of acute poisonings in patients with toxicohypoxic encephalopathy is accompanied by severe immune alterations. The alterations of proinflammation and antiinflammation cytokines have been investigated and its increase has not been revealed. It was shown, that the employment of citoflavin in intensive therapy of acute poisonings leads to decrease of the level of immunosupression.
authors.affiliation: Djanelidze Research Institute of Emergency medicine, Saint-Petersburg, Russia.
authors.forename: A
authors.initials: A
authors.lastname: Loladze
authors.forename: V
authors.initials: V
authors.lastname: Shilov
authors.forename: B
authors.initials: B
authors.lastname: Batotsyrenov
authors.forename: S
authors.initials: S
authors.lastname: Vasilyev
authors.forename: O
authors.initials: O
authors.lastname: Kuznetsov
mesh_terms: D001772:Blood Cell Count; D003024:Clozapine / Q000627:therapeutic use; D016638:Critical Illness / Q000628:therapy; D004338:Drug Combinations; D005260:Female; D005486:Flavin Mononucleotide / Q000008:administration & dosage*; D006801:Humans; D002534:Hypoxia, Brain / Q000097:blood / Q000139:chemically induced / Q000276:immunology / Q000473:pathology*; D007107:Immune System / Q000473:pathology*; D007290:Inosine Diphosphate / Q000008:administration & dosage*; D008297:Male; D020258:Neurotoxicity Syndromes / Q000097:blood / Q000276:immunology / Q000473:pathology*; D009536:Niacinamide / Q000008:administration & dosage*; D011041:Poisoning / Q000628:therapy*; D013386:Succinates / Q000008:administration & dosage*
chemical_list: D004338:Drug Combinations; D013386:Succinates; C507879:cytoflavin; D009536:Niacinamide; D005486:Flavin Mononucleotide; D007290:Inosine Diphosphate; D003024:Clozapine