title: IL-36 a new member of the IL-1 family cytokines.
abstract: Interleukin-36 (IL-36) is a pro-inflammatory cytokine which plays an important role in innate and adaptive immunity. IL-36 activates MAPK and NF-kB pathways and is produced by many different cells. This cytokine is a family member of interleukin-1 (IL-1) and plays an important role in the pathophysiology of several diseases. Here we summarise and review the new aspects of this important pro-inflammatory cytokine.
authors.forename: D
authors.initials: D
authors.lastname: Tripodi
authors.forename: F
authors.initials: F
authors.lastname: Conti
authors.forename: M
authors.initials: M
authors.lastname: Rosati
authors.forename: G
authors.initials: G
authors.lastname: Maccauro
authors.forename: A
authors.initials: A
authors.lastname: Saggini
authors.forename: E
authors.initials: E
authors.lastname: Cianchetti
authors.forename: D
authors.initials: D
authors.lastname: Angelucci
authors.forename: M
authors.initials: M
authors.lastname: Fulcheri
authors.forename: S
authors.initials: S
authors.lastname: Tetè
authors.forename: V
authors.initials: V
authors.lastname: Salini
authors.forename: A
authors.initials: A
authors.lastname: Caraffa
authors.forename: P
authors.initials: P
authors.lastname: Antinolfi
authors.forename: E
authors.initials: E
authors.lastname: Toniato
authors.forename: M L
authors.initials: ML
authors.lastname: Castellani
authors.forename: P
authors.initials: P
authors.lastname: Conti
authors.forename: T C
authors.initials: TC
authors.lastname: Theoharides
mesh_terms: D016207:Cytokines / Q000502:physiology*; D006801:Humans; D007113:Immunity, Innate; D007249:Inflammation / Q000276:immunology; D007375:Interleukin-1 / Q000737:chemistry / Q000276:immunology / Q000502:physiology*; D007674:Kidney Diseases / Q000276:immunology; D018123:Receptors, Interleukin / Q000378:metabolism; D012867:Skin / Q000276:immunology / Q000378:metabolism
chemical_list: D016207:Cytokines; D007375:Interleukin-1; D018123:Receptors, Interleukin; C572887:interleukin 36, human; C571244:interleukin-36 receptor, human