title: Biological properties and regulation of IL-10 related cytokines and their contribution to autoimmune disease and tissue injury.
abstract: The IL-10 cytokine family has nine members, four of which are located in the IL10 cluster on chromosome 1q32. These cytokines are the immune regulatory cytokine IL-10 itself, and the IL-20 subfamily members IL-19, IL-20, and IL-24. IL-10 instructs innate and adaptive immune responses and limits pro-inflammatory responses in order to prevent tissue damage. The IL-20 subfamily members are involved in host defense mechanisms, particularly from epithelial cells and seem essential for tissue integrity. Dysregulation of IL-10 family cytokines results in inflammation and autoimmune disease. Here, we discuss cellular source, gene regulation, and receptor complexes of cytokines in the IL10 cluster and their contribution to autoimmune disease and tissue damage.
authors.affiliation: Klinik und Poliklinik für Kinder- und Jugendmedizin, Universitätsklinikum Carl Gustav Carus, Technische Universität Dresden, Germany.
authors.forename: S R
authors.initials: SR
authors.lastname: Hofmann
authors.forename: A
authors.initials: A
authors.lastname: Rösen-Wolff
authors.forename: G C
authors.initials: GC
authors.lastname: Tsokos
authors.forename: C M
authors.initials: CM
authors.lastname: Hedrich
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology; D016207:Cytokines / Q000235:genetics / Q000276:immunology*; D006801:Humans; D014947:Wounds and Injuries / Q000276:immunology
chemical_list: D016207:Cytokines