title: [Midtrimester pregnancy termination--contemporary methods and techniques. Review].
abstract: The improvement in the diagnostic procedures for early detection of fetal abnormalities has led to an increase in the number of induced mid-trimester pregnancy terminations. Hence, the total number of pregnancies terminated in the second trimester comprises somewhere between 10 and 15% of all terminations, but they are responsible for 2/3 of the complications and half of the deaths. These simple facts draw our attention to the procedure. There are two main types of mid-trimester termination- surgical and medical. Surgical methods require special skills and qualification, while medical methods are considered safer and are more common. The latter group includes Oxytocin i.v., prostaglandin preparations Pg E2, Pg F2alpha, Pg E1 and their synthetic analogues, antiprogesteron drugs and etc. We have reviewed Bulgarian and foreign scientific resources and articles. We have outlined the recommendations of The Royal College of Obstetricians and Gynaecologists and William's Obstetrics. Also we have cited some relevant trials and we have made a short review of the available on the Bulgarian market prostaglandin preparations for mid-trimester pregnancy termination.
authors.forename: A
authors.initials: A
authors.lastname: Andreeva
authors.forename: B
authors.initials: B
authors.lastname: Marinov
mesh_terms: D000019:Abortifacient Agents / Q000627:therapeutic use*; D000028:Abortion, Induced / Q000379:methods*; D005260:Female; D006801:Humans; D010121:Oxytocin / Q000627:therapeutic use; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011453:Prostaglandins / Q000627:therapeutic use
chemical_list: D000019:Abortifacient Agents; D011453:Prostaglandins; D010121:Oxytocin