title: Effect of magnetite nanoparticles on living rate of MCF-7 human breast cancer cells.
abstract: Superparamagnetic and ferromagnetic magnetite nanoparticles, with diameters of approximately 13 and 44 nm, respectively, were synthesized and their uptake amount and heating efficiency were evaluated for application to magnetic hyperthermia. Both nanoparticles had almost the same zeta-potential (+10.2 mV) and hydrodynamic size (∼1 μm) and there was no significant difference in their uptake amount 18 h after they were added to the medium. After internalization, the ferromagnetic nanoparticles incorporated in human breast cancer cells (MCF-7) showed a higher heating efficiency than the superparamagnetic nanoparticles when an external magnetic field (4 kW, 250 kHz) high enough to produce heat by hysteresis loss was applied, followed by cellular death of MCF-7 with high ferromagnetic nanoparticle content.
authors.affiliation: School of Advanced Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan.
authors.forename: Daisuke
authors.initials: D
authors.lastname: Baba
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Seiko
authors.forename: Takuya
authors.initials: T
authors.lastname: Nakanishi
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Atsushi
authors.initials: A
authors.lastname: Arakaki
authors.forename: Tadashi
authors.initials: T
authors.lastname: Matsunaga
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Osaka
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D049109:Cell Proliferation / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005260:Female; D052203:Ferrosoferric Oxide / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D013329:Structure-Activity Relationship; D013499:Surface Properties; D013696:Temperature; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D052203:Ferrosoferric Oxide