title: Oxidative stress markers in hemodialysis and peritoneal dialysis patients, including coenzyme Q10 and ischemia-modified albumin.
abstract: OBJECTIVE
  Oxidative stress results from an imbalance between the production of free radicals and antioxidant activity. There is wide agreement that patients undergoing regular dialysis treatment experience increased oxidative stress. The aim of this study was to investigate serum total antioxidant status (TAS), total oxidant status (TOS), ischemia-modified albumin (IMA), and coenzyme Q10 (CoQ10) levels in hemodialysis (HD) and continuous ambulatory peritoneal dialysis (CAPD) patients, compared with controls.
  
  
  METHODS
  This study was performed on 41 (21 men, 20 women) CAPD patients, 38 (20 men,18 women) HD patients, and 43 (23 men, 20 women) healthy control subjects. CoQ10 levels were standardized using blood lipids.
  
  
  RESULTS
  Serum TAS levels and CoQ10/total cholesterol values of the HD and CAPD patients were significantly lower, whereas serum IMA and TOS levels were significantly higher, than those of controls. Furthermore, CoQ10/LDL, CoQ10/triglycerides, and CoQ10/total cholesterol + triglycerides values of the CAPD patients were significantly lower than those of controls. No differences were found between serum IMA, TAS, TOS, CoQ10 levels, and adjusted CoQ10 values of the CAPD and HD patients.
  
  
  CONCLUSIONS
  Our results suggest that oxidative stress is increased in HD and CAPD patients compared with controls, as proven by decreased TAS and adjusted CoQ10 levels and increased TOS and IMA levels. Therefore, an antioxidant supplementation to these patients may be suggested.
authors.affiliation: Department of Biochemistry, Meram Faculty of Medicine, University of Selcuk, Konya, Turkey.
authors.forename: Idris
authors.initials: I
authors.lastname: Mehmetoglu
authors.forename: F Hümeyra
authors.initials: FH
authors.lastname: Yerlikaya
authors.forename: Sevil
authors.initials: S
authors.lastname: Kurban
authors.forename: S Sami
authors.initials: SS
authors.lastname: Erdem
authors.forename: Zeki
authors.initials: Z
authors.lastname: Tonbul
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D010530:Peritoneal Dialysis; D006435:Renal Dialysis; D012709:Serum Albumin; D000075462:Serum Albumin, Human; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D015415:Biomarkers; D012709:Serum Albumin; C561522:ischemia-modified albumin; D014451:Ubiquinone; C024989:coenzyme Q10; D000075462:Serum Albumin, Human