title: Use of direct thrombin inhibitor for treatment of cerebral venous thrombosis.
abstract: Cerebral venous thrombosis is an uncommon condition with difficulties in diagnosis and treatment. There is limited study on the best treatment option for this disease. The mainstay of treatment remains systemic anticoagulation with a lengthy duration of warfarin, which has a troublesome unpredictable drug effect, various drug and food interactions, and an increased risk of bleeding. Recent availability of direct thrombin inhibitor provides an alternative option of systemic anticoagulation in various thromboembolism conditions. We report 2 cases of cerebral venous thrombosis treated with a direct thrombin inhibitor with good clinical and radiologic results.
authors.affiliation: Department of Medicine, Queen Mary Hospital, Hong Kong. sonnyhon@gmail.com
authors.forename: Sonny Fong Kwong
authors.initials: SF
authors.lastname: Hon
authors.forename: Ho Lun Terrance
authors.initials: HL
authors.lastname: Li
authors.forename: Pui Wai
authors.initials: PW
authors.lastname: Cheng
mesh_terms: D000328:Adult; D000991:Antithrombins / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000627:therapeutic use*; D002533:Cerebral Angiography / Q000379:methods; D000069604:Dabigatran; D006801:Humans; D020767:Intracranial Thrombosis / Q000175:diagnosis / Q000188:drug therapy*; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D056687:Off-Label Use; D010690:Phlebography / Q000379:methods; D016896:Treatment Outcome; D020246:Venous Thrombosis / Q000175:diagnosis / Q000188:drug therapy*; D015091:beta-Alanine / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000991:Antithrombins; D001562:Benzimidazoles; D015091:beta-Alanine; D000069604:Dabigatran