title: Hyperactivation of right inferior frontal cortex in young binge drinkers during response inhibition: a follow-up study.
abstract: OBJECTIVE
  The objective of this study was to examine brain activity, with particular attention to prefrontal function, during response execution and inhibition in youths who have engaged in binge drinking (BD) for at least 2 years.
  
  
  METHODS
  Event-related potentials (ERPs) were recorded twice within 3 years, during performance of a Go/NoGo task.
  
  
  METHODS
  The study was part of a longitudinal study of the neurocognitive effects of BD.
  
  
  METHODS
  A total of 48 undergraduate students, 25 controls (14 females) and 23 binge drinkers (10 females), with no personal or family history of alcoholism or psychopathological disorders.
  
  
  METHODS
  The Go-P3 and NoGo-P3 components of the ERPs were examined by principal component analysis and exact low-resolution tomography analysis (eLORETA).
  
  
  RESULTS
  Binge drinkers showed larger Go-P3 amplitudes than controls in the first and second evaluations (P = 0.019). They also showed larger NoGo-P3 amplitude in the second evaluation (P = 0.002). eLORETA analyses in the second evaluation revealed significantly greater activation of the right inferior frontal cortex (rIFC) in binge drinkers than in controls during successful inhibition (P < 0.05).
  
  
  CONCLUSIONS
  Young binge drinkers appear to show abnormal brain activity as measured by event-related potentials during response execution and inhibition which may represent a neural antecedent of difficulties in impulse control.
authors.affiliation: Department of Clinical Psychology and Psychobiology, University of Santiago de Compostela, Galicia, Spain. eduardo.lopez@usc.es
authors.forename: Eduardo
authors.initials: E
authors.lastname: López-Caneda
authors.forename: Fernando
authors.initials: F
authors.lastname: Cadaveira
authors.forename: Alberto
authors.initials: A
authors.lastname: Crego
authors.forename: Ana
authors.initials: A
authors.lastname: Gómez-Suárez
authors.forename: Montserrat
authors.initials: M
authors.lastname: Corral
authors.forename: María
authors.initials: M
authors.lastname: Parada
authors.forename: Francisco
authors.initials: F
authors.lastname: Caamaño-Isorna
authors.forename: Socorro
authors.initials: S
authors.lastname: Rodríguez Holguín
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D063425:Binge Drinking / Q000503:physiopathology*; D001927:Brain Diseases / Q000503:physiopathology*; D016022:Case-Control Studies; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D005500:Follow-Up Studies; D005625:Frontal Lobe / Q000503:physiopathology*; D006801:Humans; D007266:Inhibition, Psychological; D008279:Magnetic Resonance Imaging; D008297:Male; D009483:Neuropsychological Tests; D011930:Reaction Time / Q000502:physiology; D055815:Young Adult