title: Up-regulation of interleukin-6 and vascular endothelial growth factor-A in the synovial fluid of temporomandibular joints affected by synovial chondromatosis.
abstract: Our aim was to explore important inflammatory mediators for synovial chondromatosis in the temporomandibular joints (TMJs) by analysing synovial fluid. Samples were collected from 10 patients with unilateral synovial chondromatosis of the TMJ. Control samples were obtained from 11 subjects with no symptoms in the TMJ. Concentrations of aggrecan, interleukin (IL)-2, IL-4, IL-5, IL-6, IL-8 (CXCL8), IL-10, interferon (IFN)-γ, tumour necrosis factor (TNF)-α and vascular endothelial growth factor (VEGF)-A were measured in the samples of synovial fluid, and the results in the two groups compared. The tissues from the affected TMJ were examined histologically and immunohistochemically. Of the proteins evaluated, the concentrations of aggrecan, IL-6, and VEGF-A were significantly higher in the group with synovial chondromatosis. The immunohistochemical analysis showed that the synovial cells around the osteocartilaginous nodules were vigorously expressing VEGF-A. IL-6 and VEGF-A are thought to have important roles in the pathology of synovial chondromatosis of the TMJ.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Postgraduate School of Dental Medicine, Tsurumi University, Yokohama, Japan.
authors.forename: Masahiro
authors.initials: M
authors.lastname: Wake
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Hamada
authors.forename: Kenichi
authors.initials: K
authors.lastname: Kumagai
authors.forename: Nobuho
authors.initials: N
authors.lastname: Tanaka
authors.forename: Yasuko
authors.initials: Y
authors.lastname: Ikeda
authors.forename: Yasunori
authors.initials: Y
authors.lastname: Nakatani
authors.forename: Ryuji
authors.initials: R
authors.lastname: Suzuki
authors.forename: Naoshi
authors.initials: N
authors.lastname: Fukui
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D053674:Aggrecans / Q000032:analysis; D001182:Arthroscopy / Q000379:methods; D015838:Chondromatosis, Synovial / Q000473:pathology* / Q000601:surgery / Q000628:therapy; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000032:analysis; D007371:Interferon-gamma / Q000032:analysis; D016753:Interleukin-10 / Q000032:analysis; D007376:Interleukin-2 / Q000032:analysis; D015847:Interleukin-4 / Q000032:analysis; D015848:Interleukin-5 / Q000032:analysis; D015850:Interleukin-6 / Q000032:analysis*; D016209:Interleukin-8 / Q000032:analysis; D007594:Joint Loose Bodies / Q000601:surgery / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011506:Proteins / Q000032:analysis; D013582:Synovial Fluid / Q000737:chemistry*; D013583:Synovial Membrane / Q000737:chemistry / Q000473:pathology; D013704:Temporomandibular Joint / Q000473:pathology; D013705:Temporomandibular Joint Disorders / Q000473:pathology* / Q000601:surgery / Q000628:therapy; D007507:Therapeutic Irrigation / Q000379:methods; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis; D015854:Up-Regulation; D042461:Vascular Endothelial Growth Factor A / Q000032:analysis*
chemical_list: C508319:ACAN protein, human; D053674:Aggrecans; C508606:CXCL8 protein, human; C508609:IL10 protein, human; C508594:IL2 protein, human; C508598:IL4 protein, human; C508599:IL5 protein, human; C508600:IL6 protein, human; D018836:Inflammation Mediators; D007376:Interleukin-2; D015848:Interleukin-5; D015850:Interleukin-6; D016209:Interleukin-8; D011506:Proteins; D014409:Tumor Necrosis Factor-alpha; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D016753:Interleukin-10; D015847:Interleukin-4; D007371:Interferon-gamma