title: [Increase of intraepithelial lymphocytes in patients with irritable bowel syndrome].
abstract: Several studies have shown increased numbers of intraepithelial lymphocytes (IEL), mast cells, enterochromaffin cells in colonic mucosa of patients with Irritable Bowel Syndrome (IBS). Many of these findings are based is based on immunohistochemistry results, which is not available in general hospitals. Our objective is to study the histological findings observed in colon biopsies from patients with IBS compared with a group without IBS, using only histochemistry. Twenty five (25) patients were included: 16 with IBS and 9 without IBS. We found increased numbers of IEL in patients with IBS (p=0,002). A group of patients with IBS (41.9%) who fulfilled histological criteria for lymphocytic colitis were excluded. There was no significant difference in mast cells, enterochromaffin cells or eosinophils.
authors.affiliation: Hospital Nacional Daniel Alcides Carrión-Callao.
authors.forename: F
authors.initials: F
authors.lastname: Arévalo
authors.forename: V
authors.initials: V
authors.lastname: Aragon
authors.forename: P
authors.initials: P
authors.lastname: Montes
authors.forename: E
authors.initials: E
authors.lastname: Guzmán
authors.forename: E
authors.initials: E
authors.lastname: Monge
mesh_terms: D000328:Adult; D001706:Biopsy; D016022:Case-Control Studies; D003106:Colon / Q000276:immunology / Q000473:pathology*; D003113:Colonoscopy; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000276:immunology / Q000473:pathology*; D043183:Irritable Bowel Syndrome / Q000276:immunology / Q000473:pathology*; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000473:pathology*