title: Activities of proline-specific peptidases in brain structures of rats with experimental anxiety-depressive state caused by administration of dipeptidyl peptidase IV inhibitor in the early postnatal period.
abstract: We studied the dynamics of activity of dipeptidyl peptidase IV (DP-IV) and prolyl endopeptidase (PEP) in the frontal cortex, hypothalamus, striatum, nucleus accumbens, and hippocampus of rats with experimental anxiety-depression state induced by administration of methionyl-2(s)-cyano-pyrrolidine, an inhibitor of DPP-IV, in the early postnatal period. In 1-month-old experimental males, PEP and DP-IV activities increased in the frontal cortex and hypothalamus, while in 1-month-old experimental females PEP activity increased in the hippocampus and DP-IV activity increased in all studied brain structures. At the age of 3 months, increased PEP activity in the hypothalamus and nucleus accumbens was detected in males and decreased DP-IV activity in the nucleus accumbens and decreased PEP activity in the hippocampus were detected in females. At the age of 7 months, PEP activity increased in the frontal cortex and striatum and DP-IV activity increased in all studied brain structures in males; in 7-months-old females, activity of both enzymes increased in the striatum.
authors.affiliation: Laboratory for General Pathophysiology of Nervous System, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow, Russia.
authors.forename: E Yu
authors.initials: EY
authors.lastname: Kushnareva
authors.forename: N A
authors.initials: NA
authors.lastname: Krupina
authors.forename: N N
authors.initials: NN
authors.lastname: Khlebnikova
authors.forename: N N
authors.initials: NN
authors.lastname: Zolotov
authors.forename: G N
authors.initials: GN
authors.lastname: Kryzhanovskii
mesh_terms: D000818:Animals; D001007:Anxiety; D003863:Depression / Q000188:drug therapy* / Q000201:enzymology*; D054873:Dipeptidyl-Peptidase IV Inhibitors / Q000627:therapeutic use*; D005260:Female; D008297:Male; D000085822:Prolyl Oligopeptidases; D051381:Rats; D012697:Serine Endopeptidases / Q000378:metabolism*
chemical_list: D054873:Dipeptidyl-Peptidase IV Inhibitors; D012697:Serine Endopeptidases; D000085822:Prolyl Oligopeptidases