title: Dynamic asymmetric hemithioacetal transformation by lipase-catalyzed γ-lactonization: in situ tandem formation of 1,3-oxathiolan-5-one derivatives.
abstract: Dynamic hemithioacetal systems were efficiently generated in organic solvents and subsequently allowed to react with a range of lipases. This resulted in direct, dynamic asymmetric transformation of the systems, leading to optically active 1,3-oxathiolan-5-one products. The tandem process identified lipase-catalyzed lactonization as a useful method for the resolution of optimal constituents with high chemo- and stereoselectivities.
authors.affiliation: KTH Royal Institute of Technology, Department of Chemistry, Teknikringen 30, 10044 Stockholm, Sweden.
authors.forename: Morakot
authors.initials: M
authors.lastname: Sakulsombat
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Olof
authors.initials: O
authors.lastname: Ramström
mesh_terms: D002384:Catalysis; D003500:Cyclization; D007783:Lactones / Q000737:chemistry*; D008049:Lipase / Q000378:metabolism*; D015394:Molecular Structure; D013237:Stereoisomerism; D013876:Thiophenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: C574242:1,3-oxathiolan-5-one; D007783:Lactones; D013876:Thiophenes; D008049:Lipase