title: Implication of perturbed axoglial apparatus in early pediatric multiple sclerosis.
abstract: Cerebrospinal fluid samples collected from children during initial presentation of central nervous system inflammation, who may or may not subsequently be diagnosed as having multiple sclerosis (MS), were subjected to large-scale proteomics screening. Unexpectedly, major compact myelin membrane proteins typically implicated in MS were not detected. However, multiple molecules that localize to the node of Ranvier and the surrounding axoglial apparatus membrane were implicated, indicating perturbed axon-glial interactions in those children destined for diagnosis of MS.
authors.affiliation: Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University and McGill University Health Centre, Quebec, Canada.
authors.forename: Ajit Singh
authors.initials: AS
authors.lastname: Dhaunchak
authors.forename: Christopher
authors.initials: C
authors.lastname: Becker
authors.forename: Howard
authors.initials: H
authors.lastname: Schulman
authors.forename: Omar
authors.initials: O
authors.lastname: De Faria
authors.forename: Sathyanath
authors.initials: S
authors.lastname: Rajasekharan
authors.forename: Brenda
authors.initials: B
authors.lastname: Banwell
authors.forename: David R
authors.initials: DR
authors.lastname: Colman
authors.forename: Amit
authors.initials: A
authors.lastname: Bar-Or
mesh_terms: D001324:Autoantigens / Q000134:cerebrospinal fluid; D001369:Axons / Q000378:metabolism* / Q000473:pathology; D015415:Biomarkers / Q000134:cerebrospinal fluid*; D002648:Child; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D015151:Immunoblotting; D008297:Male; D013058:Mass Spectrometry; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid* / Q000473:pathology; D009185:Myelin Proteins / Q000134:cerebrospinal fluid; D009419:Nerve Tissue Proteins / Q000134:cerebrospinal fluid*; D009457:Neuroglia / Q000378:metabolism* / Q000473:pathology; D011901:Ranvier's Nodes / Q000378:metabolism / Q000473:pathology
chemical_list: D001324:Autoantigens; D015415:Biomarkers; D009185:Myelin Proteins; D009419:Nerve Tissue Proteins