title: Correlation between visual sensitivity loss and years affected for eyes with retinitis pigmentosa.
abstract: OBJECTIVE
  To determine the best clinical measures of visual sensitivity for monitoring disease progression in eyes with retinitis pigmentosa (RP).
  
  
  METHODS
  This survey retrospectively studied results from the Humphrey perimetry central 10-2 program for 123 eyes with RP with regard to the correlation between years affected by RP and clinical measures of visual dysfunction, including mean deviation (MD), average sensitivity of 12 test points (CENT12), average sensitivity of 4 central points (CEN4), foveal threshold (FT), and logarithm of the minimum angle of resolution (LogMAR).
  
  
  RESULTS
  All these value correlated more highly with years of symptoms (P < 0.001 for all) than with years since diagnosis. The correlation coefficient with years of symptoms decreased in the order MD, CENT12, CENT4, FT, and LogMAR. The order differed for a subset of 66 eyes with advanced RP having -15 dB or lower MD, and decreased in the order FT, CENT4, LogMAR and CENT12.
  
  
  CONCLUSIONS
  Progression in eyes with RP could be well assessed by use of the MD of the Humphrey central 10-2 program in general and by use of FT, CENT4, and CENT12 in cases of advanced RP.
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, 409-3898, Japan. hiijimar@yamanashi.ac.jp
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Iijima
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012174:Retinitis Pigmentosa / Q000503:physiopathology*; D012189:Retrospective Studies; D013997:Time Factors; D014786:Vision Disorders / Q000503:physiopathology*; D014792:Visual Acuity / Q000502:physiology; D058609:Visual Field Tests; D014794:Visual Fields / Q000502:physiology*; D055815:Young Adult