title: The link between angiotensin II-mediated anxiety and mood disorders with NADPH oxidase-induced oxidative stress.
abstract: The renin-angiotensin system (RAS) and its active peptide angiotensin II (AngII) have major involvements not only in hypertension but also in mood and anxiety disorders. Substantial evidence supports the notion that AngII acts as a neuromodulator in the brain. In this review, we provide an overview of the link between the RAS and anxiety or mood disorders, and focus on recent advances in the understanding of AngII-linked, NADPH oxidase-derived oxidative stress in the central nervous system, which may underlie pathogenesis of mood and anxiety disorders.
authors.forename: Feng
authors.initials: F
authors.lastname: Liu
authors.forename: Jennifer
authors.initials: J
authors.lastname: Havens
authors.forename: Qi
authors.initials: Q
authors.lastname: Yu
authors.forename: Gang
authors.initials: G
authors.lastname: Wang
authors.forename: Robin L
authors.initials: RL
authors.lastname: Davisson
authors.forename: Virginia M
authors.initials: VM
authors.lastname: Pickel
authors.forename: Costantino
authors.initials: C
authors.lastname: Iadecola