title: Fully automated synthesis of PET TSPO radioligands [11C]DAA1106 and [18F]FEDAA1106.
abstract: [(11)C]DAA1106 was prepared by O-[(11)C]methylation of DAA1123 with [(11)C]CH(3)OTf and NaH in CH(3)CN at 80°C and isolated by HPLC combined with SPE purification in 60-70% decay corrected radiochemical yield. [(18)F]FEDAA1106 was synthesized by the nucleophilic substitution of tosyloxy-FEDAA1106 in DMSO with K[(18)F]F/Kryptofix 2.2.2 at 140°C and isolated by HPLC combined with SPE purification in 30-60% decay corrected radiochemical yield. The specific activity for [(11)C]DAA1106 and [(18)F]FEDAA1106 was 370-740GBq/μmol and 37-222GBq/μmol at EOB, respectively.
authors.affiliation: Department of Radiology and Imaging Sciences, Indiana University School of Medicine, Indianapolis, IN 46202-2111, USA.
authors.forename: Min
authors.initials: M
authors.lastname: Wang
authors.forename: Mingzhang
authors.initials: M
authors.lastname: Gao
authors.forename: Qi-Huang
authors.initials: QH
authors.lastname: Zheng
mesh_terms: D000081:Acetamides / Q000138:chemical synthesis*; D002250:Carbon Radioisotopes / Q000737:chemistry; D003287:Contrast Media / Q000138:chemical synthesis; D005462:Fluorine Radioisotopes / Q000737:chemistry*; D007553:Isotope Labeling / Q000295:instrumentation / Q000379:methods*; D010647:Phenyl Ethers / Q000138:chemical synthesis*; D049268:Positron-Emission Tomography / Q000379:methods*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*; D012371:Robotics / Q000295:instrumentation / Q000379:methods*
chemical_list: D000081:Acetamides; D002250:Carbon Radioisotopes; D003287:Contrast Media; C118942:DAA 1106; D005462:Fluorine Radioisotopes; D010647:Phenyl Ethers; D019275:Radiopharmaceuticals