title: Mucoepidermoid carcinoma of the parotid as a secondary malignancy after chemotherapy in a child with neuroblastoma.
abstract: Secondary neoplasms are not reported frequently after neuroblastoma, which until recently was a cancer with limited long-term survival. Although salivary gland tumors in children and adolescents may be idiopathic, they are seen more often after head and neck radiation. We report a child with stage 4 neuroblastoma treated with high-dose multiagent chemotherapy without radiation therapy to his neck who, within 1 year of treatment, developed a low-grade but large and locally aggressive mucoepidermoid carcinoma of his parotid gland further characterized by a t(11;19)(q21;p13.1). Our patient extends the spectrum of secondary neoplasms after neuroblastoma.
authors.affiliation: Department of Pediatrics, University of North Carolina School of Medicine, Chapel Hill, NC 27599-7236, USA. jblat@med.unc.edu
authors.forename: Julie
authors.initials: J
authors.lastname: Blatt
authors.forename: Carlton
authors.initials: C
authors.lastname: Zdanski
authors.forename: Lori
authors.initials: L
authors.lastname: Scanga
authors.forename: Kathleen W
authors.initials: KW
authors.lastname: Rao
authors.forename: David E
authors.initials: DE
authors.lastname: Morris
authors.forename: William W
authors.initials: WW
authors.lastname: Shockley
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D018277:Carcinoma, Mucoepidermoid / Q000473:pathology*; D002675:Child, Preschool; D006801:Humans; D008297:Male; D016609:Neoplasms, Second Primary / Q000473:pathology*; D009447:Neuroblastoma / Q000188:drug therapy / Q000473:pathology*; D010307:Parotid Neoplasms / Q000473:pathology*