title: Pattern of urinary albumin excretion in normotensive young and adolescent Indian women with polycystic ovary syndrome.
abstract: OBJECTIVE
  Polycystic ovarian syndrome (PCOS) is a clinically heterogeneous endocrine disorder affecting up to 4-8% of women of reproductive age. The aim of this study was to evaluate the presence of microalbuminuria in women with PCOS and study its correlation with the various metabolic, clinical, and hormonal parameters.
  
  
  METHODS
  A cross-sectional study involving 69 PCOS women was carried out in a tertiary care center hospital. The diagnosis of PCOS was made according to the Rotterdam criteria. Blood samples were collected in the follicular phase of the menstrual cycle and analyzed for fasting luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin (PRL), 17-hydroxyprogesterone (17-OHP), total testosterone (T), glucose, insulin, and lipid profile. Urinary albumin was measured in the first void spot urine sample.
  
  
  RESULTS
  The mean age of the subjects was 22.0 ± 4.1 years and 21.8 ± 4.7 years in normoalbuminuric and microalbuminuric groups, respectively. Urinary albumin excretion (UAE) varied from 5 mg/l to 100 mg/ml, with a median of 5 mg/l. Microalbuminuria was observed in 17/69 (24.6%) of subjects. The mean UAE was 3.65 ± 4.44 mg/l in the normoalbuminuria group versus 45.29 ± 22.74 mg/l in the microalbuminuria group. Upon univariate analysis, hip circumference, diastolic blood pressure, and fasting blood glucose showed significant correlations with urinary albumin concentration (r = 0.264, 0.264, and 0.551, respectively; P = 0.028, 0.029, and 0.000, respectively). No association between UAE and the usual cardiovascular risk factors could be found upon regression analysis.
  
  
  CONCLUSIONS
  About 24.6% of women with PCOS showed presence of microalbuminuria in the first void spot urine sample. Screening for the presence of microalbuminuria can help in early identification of a subset of PCOS women with a high risk for future CVD, who can be subjected to preventive strategies at the earliest. However, further studies are needed before recommending routine use of UAE in PCOS cases for the detection of CVD risk.
authors.affiliation: Departments of Endocrinology, Nephrology, and Immunology and Molecular Medicine, Sheri-Kashmir Institute of Medical Sciences, Soura, Srinagar, Jammu and Kashmir, India.
authors.forename: Mohd Ashraf
authors.initials: MA
authors.lastname: Ganie
authors.forename: Khalid Jamal
authors.initials: KJ
authors.lastname: Farooqui
authors.forename: Mohd Ashraf
authors.initials: MA
authors.lastname: Bhat
authors.forename: Mohammad Muzzafar
authors.initials: MM
authors.lastname: Mir
authors.forename: Zaffar Amin
authors.initials: ZA
authors.lastname: Shah
authors.forename: Syed
authors.initials: S
authors.lastname: Douhath
authors.forename: Syed Hussain
authors.initials: SH
authors.lastname: Mir
authors.forename: Fouzia
authors.initials: F
authors.lastname: Rashid
authors.forename: Shazia
authors.initials: S
authors.lastname: Naqshi
authors.forename: Mohd Ibrahim
authors.initials: MI
authors.lastname: Masoodi
authors.forename: S A
authors.initials: SA
authors.lastname: Zargar
authors.forename: Abdul Hamid
authors.initials: AH
authors.lastname: Zargar