title: Monoacylglycerols as transmembrane Cl- anion transporters.
abstract: We report that the amphiphilic natural product, monoacylglycerol 1, functions as a transmembrane Cl(-)/NO(3)(-) anion transporter. The 1,2-diol group is crucial for the transport function since diacylglycerol and triacylglycerol analogs are not anion transporters. Furthermore, adding another hydrogen bond donor to the glycerol head-group and perfluorination of the acyl tail gave synthetic analogs with improved Cl(-) membrane transport properties.
authors.affiliation: Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, USA.
authors.forename: Soheila
authors.initials: S
authors.lastname: Bahmanjah
authors.forename: Ning
authors.initials: N
authors.lastname: Zhang
authors.forename: Jeffery T
authors.initials: JT
authors.lastname: Davis
mesh_terms: D001688:Biological Products / Q000378:metabolism; D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism*; D002712:Chlorides / Q000378:metabolism*; D008051:Lipid Bilayers / Q000378:metabolism; D050178:Monoglycerides / Q000378:metabolism*
chemical_list: D001688:Biological Products; D002712:Chlorides; D008051:Lipid Bilayers; D050178:Monoglycerides