title: Synthesis of novel heterobimetallic copper(I) hydrazone Schiff base complexes: a comparative study on the effect of heterocyclic hydrazides towards interaction with DNA/protein, free radical scavenging and cytotoxicity.
abstract: Two new copper(I) hydrazone complexes have been synthesised from bivalent copper precursor [CuCl(2)(PPh(3))(2)] and ferrocene containing bidentate hydrazone ligands HL(1) (1) or HL(2) (2). Based on the elemental analyses and spectroscopic data, the complexes are best formulated as [CuL(1)(PPh(3))(2)] (3) and [CuL(2)(PPh(3))(2)] (4) of the monovalent copper ion. Solid state structures of ligand 2 and its corresponding complex 4 were also determined. The DNA/albumin interactions of all the synthesised compounds were investigated using absorption, emission and synchronous fluorescence studies. Further, antioxidant properties of all the compounds have also been checked against ABTS, O(2)(-) and OH radicals. Additionally, the in vitro cytotoxic activity of compounds 1-4 was assessed using tumour (HeLa, A431) and non-tumour (NIH 3T3) cell lines.
authors.affiliation: Department of Chemistry, Bharathiar University, Coimbatore 641 046, India.
authors.forename: Palanisamy
authors.initials: P
authors.lastname: Sathyadevi
authors.forename: Paramasivam
authors.initials: P
authors.lastname: Krishnamoorthy
authors.forename: Rachel R
authors.initials: RR
authors.lastname: Butorac
authors.forename: Alan H
authors.initials: AH
authors.lastname: Cowley
authors.forename: Nallasamy
authors.initials: N
authors.lastname: Dharmaraj
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D001667:Binding, Competitive; D002417:Cattle; D002470:Cell Survival / Q000187:drug effects; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D004996:Ethidium / Q000737:chemistry / Q000378:metabolism; D005296:Ferrous Compounds / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D006835:Hydrazones / Q000737:chemistry*; D000075163:Metallocenes; D051379:Mice; D008958:Models, Molecular; D041681:NIH 3T3 Cells; D011485:Protein Binding; D012545:Schiff Bases / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology*; D012710:Serum Albumin, Bovine / Q000737:chemistry / Q000378:metabolism; D013057:Spectrum Analysis
chemical_list: D000975:Antioxidants; D005296:Ferrous Compounds; D006835:Hydrazones; D000075163:Metallocenes; D012545:Schiff Bases; D012710:Serum Albumin, Bovine; D003300:Copper; D004247:DNA; D004996:Ethidium; C004998:ferrocene