title: Relationship between gastroesophageal junction adenocarcinoma and Helicobacter pylori infection in Japan.
abstract: OBJECTIVE
  The relationship between gastroesophageal junction adenocarcinoma (GEJA) and Helicobacter pylori infection is not well defined; thus, we retrospectively investigated this relationship.
  
  
  METHODS
  We examined 852 cases (646 men) of gastric cancer. GEJA was defined as type II according to the classification system of Siewert and Stein. We compared the prevalence of H. pylori infection and corporal gastritis in GEJA patients with distal gastric cancer.
  
  
  RESULTS
  GEJA was observed in 80 (including 6 cases of Barrett's esophageal cancer) of the 852 cases of gastric cancer examined (9.4%). The rate of H. pylori infection was significantly lower in patients with GEJA than in patients with distal gastric cancer (73.8 vs. 94.1%, p < 0.05). The prevalence of corporal gastritis was also significantly lower in patients with GEJA than in patients with distal gastric cancer (80.7 vs. 94.6%, p < 0.05). Concurrent H. pylori infection and corporal gastritis were not observed in patients with Barrett's esophageal cancer.
  
  
  CONCLUSIONS
  Our study demonstrated that GEJA has 2 etiologic types; one of these types is associated with H. pylori infection and resembles distal gastric cancer, and the other one is not associated with H. pylori infection or Barrett's esophageal cancer.
authors.affiliation: Division of Gastroenterology, Department of Internal Medicine, Okayama Kyoritsu Hospital, Okayama, Japan. tkamada@med.kawasaki-m.ac.jp
authors.forename: Tomoari
authors.initials: T
authors.lastname: Kamada
authors.forename: Hiromichi
authors.initials: H
authors.lastname: Kurose
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Yamanaka
authors.forename: Noriaki
authors.initials: N
authors.lastname: Manabe
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kusunoki
authors.forename: Akiko
authors.initials: A
authors.lastname: Shiotani
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Inoue
authors.forename: Jiro
authors.initials: J
authors.lastname: Hata
authors.forename: Hideo
authors.initials: H
authors.lastname: Matsumoto
authors.forename: Takashi
authors.initials: T
authors.lastname: Akiyama
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Hirai
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Sadahira
authors.forename: Ken
authors.initials: K
authors.lastname: Haruma
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology* / Q000382:microbiology; D000368:Aged; D001471:Barrett Esophagus / Q000453:epidemiology* / Q000382:microbiology; D004943:Esophagogastric Junction; D005260:Female; D016481:Helicobacter Infections / Q000453:epidemiology*; D016480:Helicobacter pylori; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000453:epidemiology* / Q000382:microbiology