title: Bayesian inference of the fully specified subdistribution model for survival data with competing risks.
abstract: Competing risks data are routinely encountered in various medical applications due to the fact that patients may die from different causes. Recently, several models have been proposed for fitting such survival data. In this paper, we develop a fully specified subdistribution model for survival data in the presence of competing risks via a subdistribution model for the primary cause of death and conditional distributions for other causes of death. Various properties of this fully specified subdistribution model have been examined. An efficient Gibbs sampling algorithm via latent variables is developed to carry out posterior computations. Deviance information criterion (DIC) and logarithm of the pseudomarginal likelihood (LPML) are used for model comparison. An extensive simulation study is carried out to examine the performance of DIC and LPML in comparing the cause-specific hazards model, the mixture model, and the fully specified subdistribution model. The proposed methodology is applied to analyze a real dataset from a prostate cancer study in detail.
authors.affiliation: Clinical Bio Statistics, Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877, USA.
authors.forename: Miaomiao
authors.initials: M
authors.lastname: Ge
authors.forename: Ming-Hui
authors.initials: MH
authors.lastname: Chen
mesh_terms: D000465:Algorithms; D001499:Bayes Theorem; D003198:Computer Simulation; D006801:Humans; D016013:Likelihood Functions; D008297:Male; D008390:Markov Chains; D015233:Models, Statistical; D009010:Monte Carlo Method; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000276:immunology; D012306:Risk
chemical_list: D017430:Prostate-Specific Antigen