title: Neighborhood socioeconomic status modifies the association between individual smoking status and PAH-DNA adduct levels in prostate tissue.
abstract: Interactions between smoking and neighborhood-level socioeconomic status (SES) as risk factors for higher polycyclic aromatic hydrocarbon (PAH) DNA adduct levels in prostate tissue were investigated. PAH-DNA adducts were measured by immunohistochemistry with staining intensity measured in optical density units by semiquantitative absorbance image analysis in tumor adjacent tissue from 400 prostatectomy specimens from the Henry Ford Health System in Detroit. For each subject, their U.S. Census tract of residence was classified as being of higher or lower SES using the median value of the distribution of the proportion of tract residents with a high-school education. Generalized estimating equation models were used to assess interactions between neighborhood-level SES and smoking status, adjusting for race, age, education level, tumor volume, primary Gleason grade and prostate specific antigen (PSA) at diagnosis. There was a statistical interaction (P = 0.004) between tract-level SES and smoking status. In lower SES tracts smoking status was not associated with adduct staining, but in higher SES tracts adduct staining intensity was 13% (P = 0.01) higher in ever-smokers as compared to never-smokers. Among never-smokers, living in a lower SES tract was associated with a 25% higher mean staining intensity (P < 0.001). Neighborhood SES modifies the association between individual smoking status and PAH-DNA adduct levels in prostate tissue.
authors.affiliation: Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10032, USA. agr3@columbia.edu
authors.forename: Andrew
authors.initials: A
authors.lastname: Rundle
authors.forename: Catherine
authors.initials: C
authors.lastname: Richards
authors.forename: Christine
authors.initials: C
authors.lastname: Neslund-Dudas
authors.forename: Deliang
authors.initials: D
authors.lastname: Tang
authors.forename: Benjamin A
authors.initials: BA
authors.lastname: Rybicki
mesh_terms: D016022:Case-Control Studies; D018736:DNA Adducts / Q000378:metabolism*; D006801:Humans; D008297:Male; D011084:Polycyclic Aromatic Hydrocarbons / Q000378:metabolism*; D011467:Prostate / Q000378:metabolism*; D012907:Smoking; D012923:Social Class
chemical_list: D018736:DNA Adducts; D011084:Polycyclic Aromatic Hydrocarbons; C095911:polycyclic aromatic hydrocarbons-DNA adduct