title: Albendazole and colchicine modulate LPS-induced secretion of inflammatory mediators by liver macrophages.
abstract: Colchicine and albendazole inhibited LPS-induced secretion of TNF-α and NO in a primary culture of rat Kupffer cells. Both agents potentiated the stimulating effect of this toxin on prostaglandin E2 secretion. The amount of prostaglandin D2 remained unchanged under these conditions.
authors.affiliation: Laboratory for Molecular Mechanisms of Infection, Research Institute of Epidemiology, Moscow, Russia. viktorov_av@yahoo.com
authors.forename: A V
authors.initials: AV
authors.lastname: Viktorov
authors.forename: V A
authors.initials: VA
authors.lastname: Yurkiv
mesh_terms: D015766:Albendazole / Q000494:pharmacology*; D000818:Animals; D002478:Cells, Cultured; D003078:Colchicine / Q000494:pharmacology*; D018836:Inflammation Mediators / Q000378:metabolism*; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008264:Macrophages / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D018836:Inflammation Mediators; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha; D015766:Albendazole; D003078:Colchicine