title: Organocatalytic asymmetric synthesis of trifluoromethyl-substituted diarylpyrrolines: enantioselective conjugate cyanation of β-aryl-β-trifluoromethyl-disubstituted enones.
abstract: Ether way: the cinchona-alkaloid-catalyzed title reaction was achieved in high yields with high to excellent ee values for the first time, and affords key intermediates for the biologically important 2 having a trifluoromethylated all-carbon quaternary chiral center. Ether-type catalysts (1) are more efficient in this transformation than the conventional hydroxy analogues.
authors.affiliation: Department of Frontier Materials, Graduate School of Engineering, Nagoya Institute of Technology, Gokiso, Showa-ku, Japan.
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kawai
authors.forename: Satoshi
authors.initials: S
authors.lastname: Okusu
authors.forename: Etsuko
authors.initials: E
authors.lastname: Tokunaga
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Sato
authors.forename: Motoo
authors.initials: M
authors.lastname: Shiro
authors.forename: Norio
authors.initials: N
authors.lastname: Shibata
mesh_terms: D002384:Catalysis; D018360:Crystallography, X-Ray; D003485:Cyanates / Q000737:chemistry; D006845:Hydrocarbons, Fluorinated / Q000737:chemistry*; D007555:Isoxazoles / Q000737:chemistry; D015394:Molecular Structure; D011758:Pyrroles / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D003485:Cyanates; D006845:Hydrocarbons, Fluorinated; D007555:Isoxazoles; D011758:Pyrroles; C013231:pyrroline