title: Iron status and fibroblast growth factor-23 in Gambian children.
abstract: A relationship between iron and fibroblast growth factor-23 (FGF23) metabolic pathways has been proposed. Iron deficiency anaemia is prevalent in The Gambia and concentrations of fibroblast growth factor-23 FGF23 are elevated in a large percentage of Gambian children with rickets-like bone deformity. We speculate that low iron status may be involved in the aetiology of Gambian rickets. The aim of this study was to determine if there was a relationship between haemoglobin, as a marker of iron status, and FGF23 in samples from children with and without a history of rickets-like bone deformities in The Gambia. We conducted a retrospective analysis of studies carried out from 2006 to 2008 in children from a rural community in The Gambia where iron deficiency anaemia is endemic and where elevated circulating concentrations of FGF23 have been found. To investigate the relationship between circulating FGF23 and haemoglobin concentrations we used an age-adjusted linear regression model on data from children <18y of age with a family or personal history of rickets-like bone deformity (BD) (n=108) and from the local community (LC) (n=382). We found that circulating concentration of FGF23 was inversely correlated with haemoglobin concentration. This effect was more pronounced in BD children compared with LC children (interaction: P≤0.0001). Anaemia and elevated FGF23 were more prevalent in BD children compared to LC children (P=0.0003 and P=0.0001 respectively). In conclusion, there is a stronger relationship between FGF23 and haemoglobin in Gambian children with a history of rickets compared to local community children. This study provides support for the contention that iron may be involved in FGF23 metabolic pathways.
authors.affiliation: Medical Research Council (MRC) Human Nutrition Research, Cambridge, UK. Vickie.braithwaite@mrc-hnr.cam.ac.uk
authors.forename: Vickie
authors.initials: V
authors.lastname: Braithwaite
authors.forename: Landing M A
authors.initials: LM
authors.lastname: Jarjou
authors.forename: Gail R
authors.initials: GR
authors.lastname: Goldberg
authors.forename: Ann
authors.initials: A
authors.lastname: Prentice
mesh_terms: D000293:Adolescent; D018798:Anemia, Iron-Deficiency / Q000097:blood / Q000150:complications / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D000089703:Fibroblast Growth Factor-23; D005346:Fibroblast Growth Factors / Q000097:blood*; D005714:Gambia / Q000453:epidemiology; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007501:Iron / Q000097:blood*; D016014:Linear Models; D008297:Male; D053858:Metabolic Networks and Pathways; D015995:Prevalence; D012189:Retrospective Studies; D012279:Rickets / Q000097:blood / Q000453:epidemiology / Q000209:etiology
chemical_list: C000717427:FGF23 protein, human; D006454:Hemoglobins; D005346:Fibroblast Growth Factors; D000089703:Fibroblast Growth Factor-23; D007501:Iron