title: The leucocyte β2 (CD18) integrins: the structure, functional regulation and signalling properties.
abstract: Leucocytes are highly motile cells. Their ability to migrate into tissues and organs is dependent on cell adhesion molecules. The integrins are a family of heterodimeric transmembrane cell adhesion molecules that are also signalling receptors. They are involved in many biological processes, including the development of metazoans, immunity, haemostasis, wound healing and cell survival, proliferation and differentiation. The leucocyte-restricted β2 integrins comprise four members, namely αLβ2, αMβ2, αXβ2 and αDβ2, which are required for a functional immune system. In this paper, the structure, functional regulation and signalling properties of these integrins are reviewed.
authors.affiliation: Division of Molecular Genetics and Cell Biology, School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore.
authors.forename: Suet-Mien
authors.initials: SM
authors.lastname: Tan
mesh_terms: D000818:Animals; D018821:CD18 Antigens / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D015815:Cell Adhesion Molecules / Q000378:metabolism; D006801:Humans; D007113:Immunity, Innate; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism; D007962:Leukocytes / Q000378:metabolism; D054730:Protein Interaction Domains and Motifs; D017433:Protein Structure, Secondary; D015398:Signal Transduction
chemical_list: D018821:CD18 Antigens; D015815:Cell Adhesion Molecules; D047908:Intracellular Signaling Peptides and Proteins