title: Relationship between acute chest syndrome and the sympatho-vagal balance in adults with hemoglobin SS disease; a case control study.
abstract: The present study evaluated the relationship between acute chest syndrome (ACS) and autonomic nervous system (ANS) activity in patients with hemoglobin SS disease (Hb SS). Nine patients had suffered ACS were matched by age and gender to patients who had not suffered ACS and ANS activity, pulmonary function and history of painful crisis were compared. Correlations between number of episodes of ACS suffered and these variables were determined. The results demonstrated that 1) patients with a history of ACS ever had lower parasympathetic nervous system (PNS) activity and lower global ANS activity than patients with no ACS ever (p < 0.05), 2) the number of ACS episodes ever negatively correlated (p < 0.05) with PNS activity and global ANS activity and 3) There were no significant associations between lung function or a history of painful crisis in these patients. In conclusion, a history of ACS was associated with ANS dysfunction in adults with Hb SS disease.
authors.affiliation: Tropical Medicine Research Institute, University of the West Indies, Mona, Kingston, Jamaica, West Indies.
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Knight-Madden
authors.forename: Philippe
authors.initials: P
authors.lastname: Connes
authors.forename: Andre
authors.initials: A
authors.lastname: Bowers
authors.forename: Danitza
authors.initials: D
authors.lastname: Nebor
authors.forename: Marie-Dominique
authors.initials: MD
authors.lastname: Hardy-Dessources
authors.forename: Marc
authors.initials: M
authors.lastname: Romana
authors.forename: Harvey
authors.initials: H
authors.lastname: Reid
authors.forename: Aurélien P
authors.initials: AP
authors.lastname: Pichon
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Barthélémy
authors.forename: Vanessa B
authors.initials: VB
authors.lastname: Cumming
authors.forename: Jacques
authors.initials: J
authors.lastname: Elion
authors.forename: Marvin
authors.initials: M
authors.lastname: Reid
mesh_terms: D056586:Acute Chest Syndrome / Q000503:physiopathology*; D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications* / Q000503:physiopathology; D001341:Autonomic Nervous System / Q000503:physiopathology*; D016022:Case-Control Studies; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D008297:Male; D010275:Parasympathetic Nervous System / Q000503:physiopathology; D014630:Vagus Nerve / Q000503:physiopathology