title: Intra-arterial thrombolysis as an ideal treatment for inflammatory bowel disease related thromboembolic stroke: a case report and review.
abstract: Thromboembolism, both venous and arterial, is a well-known complication of inflammatory bowel disease, with the risk of stroke highest when patients are less than 50 years of age. Because inflammatory bowel disease patients often have gastrointestinal bleeding, it is a challenge to treat their thromboembolic events with systemic therapy. In this case, a 42-year-old woman with Crohn's disease developed a thromboembolism in her middle cerebral artery and was successfully treated with local intra-arterial thrombolysis. There is a growing trend to treat thromboembolic events in inflammatory bowel disease patients with local thrombolysis as it leads to better outcomes with regards to both the resolution of the thromboembolism and decreased secondary gastrointestinal bleeding.
authors.affiliation: Department of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA. jbrosch@iupui.edu
authors.forename: Jared R
authors.initials: JR
authors.lastname: Brosch
authors.forename: Mark J
authors.initials: MJ
authors.lastname: Janicki
mesh_terms: D000328:Adult; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000150:complications / Q000628:therapy; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications*; D010446:Peptide Fragments / Q000008:administration & dosage; D020521:Stroke / Q000150:complications*; D013923:Thromboembolism / Q000150:complications*; D015912:Thrombolytic Therapy / Q000379:methods*; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage
chemical_list: D010446:Peptide Fragments; C550736:arginyl-asparagyl-prolyl-aspartyl-glycyl-aspartyl-alanyl-lysyl-prolyl-tryptophan; D010959:Tissue Plasminogen Activator