title: Termitomycesphins G and H, additional cerebrosides from the edible Chinese mushroom Termitomyces albuminosus.
abstract: Two new cerebrosides, termitomycesphins G and H, were isolated from the edible Chinese mushroom, Termitomyces albuminosus (Berk.) Herm., and exhibited neuritogenic activity against PC12 cells. Their structures and absolute stereochemistry were elucidated by spectroscopic methods and by a comparison of the specific rotation of the hydrogenated products from termitomycesphins H and C. These cerebrosides possessed a unique modification by a hydroxyl group at the middle of the long-chain base, like earlier congeners termitomycesphins A-F. Termitomycesphin G with a 16-carbon-chain fatty acid showed higher neuritogenic activity than that of termitomycesphin H with an 18-carbon-chain fatty acid. This effect was observed within the termitomycesphins, suggesting that the chain length of the fatty acyl moiety played a key role in the neuritogenic activity.
authors.affiliation: College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
authors.forename: Yuan
authors.initials: Y
authors.lastname: Qu
authors.forename: Kaiyue
authors.initials: K
authors.lastname: Sun
authors.forename: Lijuan
authors.initials: L
authors.lastname: Gao
authors.forename: Youji
authors.initials: Y
authors.lastname: Sakagami
authors.forename: Hirokazu
authors.initials: H
authors.lastname: Kawagishi
authors.forename: Makoto
authors.initials: M
authors.lastname: Ojika
authors.forename: Jianhua
authors.initials: J
authors.lastname: Qi
mesh_terms: D000818:Animals; D048708:Cell Growth Processes / Q000187:drug effects* / Q000502:physiology; D002554:Cerebrosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002681:China; D005227:Fatty Acids / Q000494:pharmacology; D005963:Glucosylceramides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008858:Microscopy, Phase-Contrast; D016501:Neurites / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D016716:PC12 Cells; D051381:Rats; D055434:Termitomyces / Q000737:chemistry*
chemical_list: D002554:Cerebrosides; D005227:Fatty Acids; D005963:Glucosylceramides; C576238:termitomycesphin G; C576239:termitomycesphin H