title: Effects of clinoptilolite treatment on oxidative stress after partial hepatectomy in rats.
abstract: OBJECTIVE
  Clinoptilolite is a natural zeolite crystal. Cytoprotective effects of clinoptilolite have been reported. However, so far there are no data about the effects of clinoptilolite treatment on oxidative stress after partial hepatectomy. In this experimental study, the effects of clinoptilolite treatment after partial hepatectomy on oxidative stress were evaluated.
  
  
  METHODS
  There were four experimental groups (n=8): Group S, the sham group; Group H, the hepatectomy group; Group HC, the clinoptilolite treatment after partial hepatectomy group; and Group CS, the clinoptilolite-treated sham group. A 70% partial hepatectomy was performed for Group H and HC. Clinoptilolite (5mg/kg) was given to the rats orally (via gavage tube) twice a day for 10 days after hepatectomy. Malondialdehyde (MDA), Cu-Zn super oxide dismutase (SOD), and glutathione (GSH) levels were assessed to evaluate oxidative stress.
  
  
  RESULTS
  Plasma and liver tissue MDA levels of Group HC were significantly lower than the H group (p=0.018 and p=0.000, respectively). Liver tissue Cu-Zn SOD activity and GSH levels of Group HC were significantly higher than Group H (p=0.003, p=0.007, respectively).
  
  
  CONCLUSIONS
  Clinoptilolite administration reduces oxidant activity and supports antioxidant response after partial hepatectomy.
authors.affiliation: Istanbul University, Department of General Surgery, Istanbul, Turkey. kayasaribeyoglu@gmail.com
authors.forename: Kaya
authors.initials: K
authors.lastname: Saribeyoglu
authors.forename: Erman
authors.initials: E
authors.lastname: Aytac
authors.forename: Salih
authors.initials: S
authors.lastname: Pekmezci
authors.forename: Seha
authors.initials: S
authors.lastname: Saygili
authors.forename: Hafize
authors.initials: H
authors.lastname: Uzun
authors.forename: Gulsen
authors.initials: G
authors.lastname: Ozbay
authors.forename: Seval
authors.initials: S
authors.lastname: Aydin
authors.forename: Hakki Oktay
authors.initials: HO
authors.lastname: Seymen
mesh_terms: D000284:Administration, Oral; D000818:Animals; D015415:Biomarkers / Q000378:metabolism; D004334:Drug Administration Schedule; D005978:Glutathione / Q000378:metabolism; D006498:Hepatectomy; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism; D017641:Zeolites / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D015415:Biomarkers; C083175:clinoptilolite; D017641:Zeolites; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D005978:Glutathione