title: Four new sesquiterpenes from Commiphora myrrha and their neuroprotective effects.
abstract: Four new sesquiterpenes, myrrhterpenoids K-N (1-4) have been isolated from the resin of Commiphora myrrha. Their structures and relative configurations were elucidated by spectroscopic methods (IR, ESIMS, HR-ESIMS, 1D and 2D NMR). Compounds 1 and 4 showed neuroprotective effects against MPP(+)-induced neuronal cell death in SH-SY5Y cells.
authors.affiliation: College of Pharmacy, State Key Laboratory of Medicinal Chemical Biology and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Xu
authors.forename: Yuanqiang
authors.initials: Y
authors.lastname: Guo
authors.forename: Peng
authors.initials: P
authors.lastname: Zhao
authors.forename: Ping
authors.initials: P
authors.lastname: Guo
authors.forename: Yonggang
authors.initials: Y
authors.lastname: Ma
authors.forename: Chunfeng
authors.initials: C
authors.lastname: Xie
authors.forename: Da-qing
authors.initials: DQ
authors.lastname: Jin
authors.forename: Liping
authors.initials: L
authors.lastname: Gui
mesh_terms: D016923:Cell Death / Q000187:drug effects*; D002460:Cell Line; D029744:Commiphora / Q000737:chemistry*; D006801:Humans; D015394:Molecular Structure; D018696:Neuroprotective Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D012116:Resins, Plant; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: C518724:CML-1 plant extract; D018696:Neuroprotective Agents; D010936:Plant Extracts; D012116:Resins, Plant; D012717:Sesquiterpenes