title: Isolation and structural elucidation of abietic acid as the main adulterant in an herbal drug for the treatment of psoriasis.
abstract: An herbal drug for the treatment of psoriasis showed severe clinical adverse reactions. The main component of adulterant was isolated from the drug and its chemical structure was elucidated as abietic acid using NMR, HR-MS, and HPLC-DAD-MS. Although abietic acid had ever been used in clinical study for the treatment of psoriasis, it is not an approved drug. Its adulteration is very dangerous for the patients.
authors.affiliation: National Institutes for Food and Drug Control, Tiantan Xili 2, Beijing 100050, China.
authors.forename: Yi
authors.initials: Y
authors.lastname: He
authors.forename: Yumei
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Lu
authors.forename: Ruichao
authors.initials: R
authors.lastname: Lin
mesh_terms: D045784:Abietanes / Q000302:isolation & purification*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003879:Dermatologic Agents / Q000009:adverse effects / Q000032:analysis* / Q000592:standards; D004340:Drug Contamination; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D013058:Mass Spectrometry / Q000379:methods; D010936:Plant Extracts / Q000009:adverse effects / Q000032:analysis* / Q000592:standards; D011565:Psoriasis / Q000188:drug therapy
chemical_list: D045784:Abietanes; D003879:Dermatologic Agents; D010936:Plant Extracts; C023710:abietic acid