title: Ultrasonics promoted synthesis of thiazolidinones from 2-aminopyridine and 2-picolilamine.
abstract: The efficient multicomponent synthesis of thiazolidinones from the reaction of arenealdehydes, mercaptoacetic acid and 2-picolilamine or 2-aminopyridine under ultrasound irradiation are reported. The reaction with 2-aminopyridine needs a Lewis acid catalysis to afford the corresponding 2-aryl-3-(pyridin-2-yl)-1,3-thiazolidin-4-ones. All novel compounds were identified and characterized by (1)H and (13)C NMR spectra. Applying the sonochemical methodology, two series of heterocyclic thiazolidinones were synthesized in good yields after short reaction times.
authors.affiliation: Núcleo de Química Aplicada, Universidade Federal de Pelotas - UFPel, Campus Universitário, s/n°, 96010-900 Pelotas, RS, Brazil.
authors.forename: Daniela P
authors.initials: DP
authors.lastname: Gouvêa
authors.forename: Valéria D O
authors.initials: VD
authors.lastname: Bareño
authors.forename: Juliano
authors.initials: J
authors.lastname: Bosenbecker
authors.forename: Bruna B
authors.initials: BB
authors.lastname: Drawanz
authors.forename: Patrícia D
authors.initials: PD
authors.lastname: Neuenfeldt
authors.forename: Geonir M
authors.initials: GM
authors.lastname: Siqueira
authors.forename: Wilson
authors.initials: W
authors.lastname: Cunico
mesh_terms: D000631:Aminopyridines / Q000737:chemistry*; D015394:Molecular Structure; D010848:Picolinic Acids / Q000737:chemistry*; D053778:Thiazolidines / Q000138:chemical synthesis* / Q000737:chemistry; D014465:Ultrasonics
chemical_list: D000631:Aminopyridines; D010848:Picolinic Acids; D053778:Thiazolidines; C032439:alpha-aminopyridine