title: Hepatoblastoma in a mosaic trisomy 18 patient.
abstract: We report a case of hepatoblastoma in a 10-year-old girl with mosaic-type trisomy 18. A comprehensive literature review reveals only 2 cases involving mosaic trisomy 18 patients. Our patient underwent an abbreviated chemotherapy course before complete surgical resection. Her hepatoblastoma did not contain cells with trisomy 18. The conservative management approach resulted in a successful outcome; she remains disease free >2 years after surgery. Along with presenting a literature review, this report demonstrates a favorable outcome in a mosaic trisomy 18 child with hepatoblastoma where tumor cells lacked a trisomy 18 karyotype.
authors.affiliation: Departments of Genetics, Montefiore Medical Center, Bronx, NY, USA.
authors.forename: Elaine Maria
authors.initials: EM
authors.lastname: Pereira
authors.forename: Robert
authors.initials: R
authors.lastname: Marion
authors.forename: K H
authors.initials: KH
authors.lastname: Ramesh
authors.forename: Jane S
authors.initials: JS
authors.lastname: Kim
authors.forename: Michelle
authors.initials: M
authors.lastname: Ewart
authors.forename: Rosanna
authors.initials: R
authors.lastname: Ricafort
mesh_terms: D002648:Child; D002887:Chromosomes, Human, Pair 18 / Q000235:genetics*; D005260:Female; D018197:Hepatoblastoma / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis / Q000235:genetics / Q000628:therapy; D009030:Mosaicism; D012074:Remission Induction; D014314:Trisomy