title: Elf5, hormones and cell fate.
abstract: Recent elucidation of the stem and progenitor cell hierarchies that operate during normal tissue and organ development has provided a foundation for the development of new insights into the disease process. These hierarchies are established by genetic mechanisms, which specify and determine cell fate and act as cell-clade gatekeepers, upon which all multicellular organisms depend for viability. Perturbation of this gatekeeper function characterizes developmentally based diseases, such as cancer. Here, the emerging gatekeeper and master regulatory roles of the ETS transcription factor Elf5 in several diverse developmental scenarios is reviewed, and how this function intersects with hormonal and growth factor mediated regulation of these processes is shown.
authors.affiliation: Cancer Research Program, Garvan Institute of Medical Research, 384 Victoria St., Darlinghurst, NSW 2010, Australia.
authors.forename: Heather J
authors.initials: HJ
authors.lastname: Lee
authors.forename: Christopher J
authors.initials: CJ
authors.lastname: Ormandy
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology*; D002471:Cell Transformation, Neoplastic; D004268:DNA-Binding Proteins / Q000502:physiology; D005260:Female; D006728:Hormones / Q000502:physiology*; D006801:Humans; D008321:Mammary Glands, Animal / Q000166:cytology / Q000196:embryology / Q000254:growth & development; D051379:Mice; D023421:Models, Animal; D050783:Proto-Oncogene Proteins c-ets / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology
chemical_list: D004268:DNA-Binding Proteins; C116038:ELF5 protein, human; C500759:Elf5 protein, mouse; D006728:Hormones; D050783:Proto-Oncogene Proteins c-ets; D014157:Transcription Factors