title: Correlation and agreement between contrast-enhanced ultrasonography and perfusion computed tomography for assessment of liver metastases from endocrine tumors: normalization enhances correlation.
abstract: We studied correlation and agreement between perfusion parameters derived from contrast-enhanced ultrasonography (CEUS) and computed tomography (CT). Both techniques were performed in 16 patients with proven liver metastases from endocrine tumor. Replenishment study after ultrasound-induced destruction of microbubbles was used for CEUS quantification. CEUS-derived relative values of blood flow, blood volume and mean transit time were compared with perfusion CT-derived parameters measured in the same tumors. Significant correlation was observed between CEUS normalized values and CT absolute tumor values for blood flow (r = 0.58; p = 0.018), blood volume (r = 0.61; p = 0.012) and mean transit time (r = 0.52; p = 0.037). Correlation was not significant for non-normalized values. Agreement between CEUS normalized values and perfusion CT relative values was significant (p < 0.04). Estimated bias between CEUS and CT for relative perfusion values was -1.38 (-5.02; 2.27) for blood flow, +0.26 (-0.79; 1.31) for blood volume and +0.21 (-0.46; 0.87) for mean transit time. We conclude that normalization markedly increased correlation between CEUS- and CT-derived perfusion values and allowed agreement assessment.
authors.affiliation: Abdominal Imaging Unit, Edouard Herriot Hospital, Hospices Civils de Lyon, Lyon, France.
authors.forename: Thibaud
authors.initials: T
authors.lastname: Lefort
authors.forename: Frank
authors.initials: F
authors.lastname: Pilleul
authors.forename: Sébastien
authors.initials: S
authors.lastname: Mulé
authors.forename: S Lori
authors.initials: SL
authors.lastname: Bridal
authors.forename: Frédérique
authors.initials: F
authors.lastname: Frouin
authors.forename: Catherine
authors.initials: C
authors.lastname: Lombard-Bohas
authors.forename: Thomas
authors.initials: T
authors.lastname: Walter
authors.forename: Olivier
authors.initials: O
authors.lastname: Lucidarme
authors.forename: Aymeric
authors.initials: A
authors.lastname: Guibal
mesh_terms: D000328:Adult; D000368:Aged; D001810:Blood Volume; D003287:Contrast Media; D004701:Endocrine Gland Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D007472:Iohexol / Q000031:analogs & derivatives; D008113:Liver Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D010743:Phospholipids; D018709:Statistics, Nonparametric; D013459:Sulfur Hexafluoride; D014057:Tomography, X-Ray Computed / Q000379:methods*; D014463:Ultrasonography
chemical_list: D003287:Contrast Media; D010743:Phospholipids; C420843:contrast agent BR1; C093233:iobitridol; D007472:Iohexol; D013459:Sulfur Hexafluoride