title: Comparison of bioconcentration and biomagnification factors for poorly water-soluble chemicals using common carp (Cyprinus carpio L.).
abstract: Existing regulatory criteria for bioaccumulation assessment of chemicals are mainly based on a bioconcentration factors (BCF) not a biomagnification factors (BMF). We performed dietary exposure tests for nine poorly water-soluble chemicals and developed a linear regression between the 5 % lipid normalized BCF (BCF(L)) and the lipid-corrected BMF (BMF(L)). The BMF(L) of substances with BCF(L) = 5,000 was 0.31 (95 % CI 0.11-0.87), whereas the BCF(L) of substances with BMF(L) = 1 was 13,000 (95 % CI 5,600-30,000). Five substances can be considered very bioaccumulative (vB) according to the BCF end point (BCF > 5,000), but only two substances were recognized to biomagnify according to the BMF end point (BMF ≥ 1). Although our results are highly suggestive of a relationship between BCF and BMF, additional BMF and trophic magnification factor data for chemicals are required to support this relationship, and new techniques (e.g., fugacity approach) may help in resolving the apparent contradiction in hazard categorization.
authors.affiliation: CERI Kurume, Chemicals Evaluation and Research Institute, Kurume-shi, Fukuoka, 839-0801, Japan. inoue-yoshiyuki@ceri.jp
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Inoue
authors.forename: Naoki
authors.initials: N
authors.lastname: Hashizume
authors.forename: Tomohiko
authors.initials: T
authors.lastname: Yoshida
authors.forename: Hidekazu
authors.initials: H
authors.lastname: Murakami
authors.forename: Yasuyuki
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Yuka
authors.initials: Y
authors.lastname: Koga
authors.forename: Ryoko
authors.initials: R
authors.lastname: Takeshige
authors.forename: Erina
authors.initials: E
authors.lastname: Kikushima
authors.forename: Naoaki
authors.initials: N
authors.lastname: Yakata
authors.forename: Masanori
authors.initials: M
authors.lastname: Otsuka
mesh_terms: D000818:Animals; D002347:Carps / Q000378:metabolism*; D004784:Environmental Monitoring / Q000379:methods*; D020387:Food Chain; D005506:Food Contamination; D016014:Linear Models; D012995:Solubility; D014874:Water Pollutants, Chemical / Q000493:pharmacokinetics*
chemical_list: D014874:Water Pollutants, Chemical