title: Clinical relevance of scaffolds for cartilage engineering.
abstract: The repair of articular cartilage defects in patients' knees presents a particular challenge to the orthopedic surgeon because cartilage lacks the ability to repair or regenerate itself. Various cartilage repair techniques have not produced a superior or uniform outcome, which has led to a new generation of cartilage repair based on tissue-engineering strategies and the use of biological scaffolds. Clinical advances have been made regarding the regeneration of articular cartilage, and continue to be made toward the achievement of a suitable treatment method for resurfacing osteochondral defects, through cartilage tissue engineering and the use of pluripotent cells seeded on bio-scaffolds.
authors.affiliation: Department of Orthopaedics, Long Island Jewish Medical Center, Street 270-05 76th Avenue, New Hyde Park, NY 11040, USA. tlaporta@aecom.yu.edu
authors.forename: Thomas F
authors.initials: TF
authors.lastname: LaPorta
authors.forename: Alexander
authors.initials: A
authors.lastname: Richter
authors.forename: Nicholas A
authors.initials: NA
authors.lastname: Sgaglione
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Grande
mesh_terms: D002358:Cartilage, Articular / Q000473:pathology / Q000601:surgery*; D019902:Chondrocytes / Q000637:transplantation; D005260:Female; D006801:Humans; D007718:Knee Injuries / Q000000981:diagnostic imaging / Q000534:rehabilitation / Q000601:surgery*; D008297:Male; D010147:Pain Measurement; D011859:Radiography; D016059:Range of Motion, Articular / Q000502:physiology*; D012307:Risk Factors; D012680:Sensitivity and Specificity; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds; D014182:Transplantation, Autologous; D016896:Treatment Outcome