title: Lack of association between the 8-oxoguanine DNA glycosylase gene Ser326Cys polymorphism and gastric cancer: evidence from a meta-analysis.
abstract: OBJECTIVE
  To evaluate the association of 8-oxoguanine DNA glycosylase gene (OGG1) Ser326Cys polymorphism with gastric cancer via a comprehensive meta-analysis.
  
  
  METHODS
  A total of 12 publications were identified before January 20, 2011 including 1,390 cases and 3,299 controls. A random-effects model was applied irrespective of between-study heterogeneity. Data and study quality were assessed in duplicate.
  
  
  RESULTS
  No significant association was found for either allele or genotype with gastric cancer (odds ratio [OR]=0.96; 95% confidence interval [95% CI]: 0.82-1.13; P=0.66), and this was also the case after combining 326Ser/Cys and 326Ser/Ser genotypes together (OR=0.87; 95% CI: 0.63-1.20; P=0.40), or 326Cys/Cys and 326Ser/Cys together (OR=1.03; 95% CI: 0.87-1.22; P=0.72). Subgroup analysis by ethnicity indicated that comparison of allele 326Ser versus 326Cys generated a weakly and non-significant protective effect on gastric cancer in Asians (OR=0.90; 95% CI: 0.75-1.09; P=0.29) and Turks (OR=0.65; 95% CI: 0.37-1.14; P=0.13), but a non-significant risk effect in Europeans (OR=1.10; 95% CI: 0.78-1.54; P=0.60) and Brazilians (OR=1.13; 95% CI: 0.81-1.58; P=0.48). No publication bias was observed.
  
  
  CONCLUSIONS
  Our results collectively suggest that the OGG1 Ser326Cys polymorphism might not be a potential candidate risk factor for the development of gastric cancer.
authors.affiliation: Department of Gastroenterology, Shanghai Jiaotong University School of Medicine, Shanghai, China.
authors.forename: Zhengting
authors.initials: Z
authors.lastname: Wang
authors.forename: Jiajia
authors.initials: J
authors.lastname: Hu
authors.forename: Wei
authors.initials: W
authors.lastname: Cai
authors.forename: Jie
authors.initials: J
authors.lastname: Zhong
mesh_terms: D016022:Case-Control Studies; D045647:DNA Glycosylases / Q000235:genetics*; D005838:Genotype; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D012307:Risk Factors; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology*
chemical_list: D045647:DNA Glycosylases; C479058:oxoguanine glycosylase 1, human