title: Antiepileptic drugs and vitamin B6 plasma levels in adult patients.
abstract: Treatment with several antiepileptic drugs (AED) is associated with lower serum concentrations of folate or vitamin B12. This prospective monocenter study analyzed vitamin B6 blood levels in 400 serial patients with epilepsy, AED-treated (n=385), untreated (n=15) and healthy controls (n=233). The mean plasma vitamin B6 levels of the AED-treated (12.1±10.1; p=0.093) and the untreated patients (15.6±12.4; p=0.664) were not significantly different from the controls (13.9±15.2). These observations do not support the hypothesis that vitamin B6 blood levels are influenced by AED treatment.
authors.affiliation: Department of Neurology, University Hospital Zurich, Frauenklinikstrasse 26, Zurich, Switzerland. michael.linnebank@usz.ch
authors.forename: Michael
authors.initials: M
authors.lastname: Linnebank
authors.forename: Susanna
authors.initials: S
authors.lastname: Moskau
authors.forename: Alexander
authors.initials: A
authors.lastname: Semmler
authors.forename: Guido
authors.initials: G
authors.lastname: Widman
authors.forename: Michael
authors.initials: M
authors.lastname: Weller
authors.forename: Ulf
authors.initials: U
authors.lastname: Kallweit
authors.forename: Christian E
authors.initials: CE
authors.lastname: Elger
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D004827:Epilepsy / Q000097:blood / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D025101:Vitamin B 6 / Q000097:blood*
chemical_list: D000927:Anticonvulsants; D025101:Vitamin B 6