title: Antioxidant and antiproliferative activity of Hypericum hircinum L. subsp. majus (Aiton) N. Robson essential oil.
abstract: This study was undertaken to assess the antioxidant and antiproliferative potential of the essential oil of Hypericum hircinum L. subsp. majus (Aiton) N. Robson. Analysis of the oil composition revealed that sesquiterpene hydrocarbons (69.3%) dominate, cis-β-guaiene, δ-selinene and (E)-caryophyllene being the most representative. Significant values of antioxidant activity were found using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) radical scavenging assays. The essential oil revealed antiproliferative activity as evaluated on human glioblastoma (T98G), human prostatic adenocarcinoma (PC3), human squamous carcinoma (A431) and mouse melanoma (B16-F1) tumour cell lines by MTT assay.
authors.affiliation: School of Pharmacy, Drugs and Health Products, University of Camerino, Via Gentile III da Varano, I-62032 Camerino, MC, Italy.
authors.forename: Luana
authors.initials: L
authors.lastname: Quassinti
authors.forename: Giulio
authors.initials: G
authors.lastname: Lupidi
authors.forename: Filippo
authors.initials: F
authors.lastname: Maggi
authors.forename: Gianni
authors.initials: G
authors.lastname: Sagratini
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Papa
authors.forename: Sauro
authors.initials: S
authors.lastname: Vittori
authors.forename: Armandodoriano
authors.initials: A
authors.lastname: Bianco
authors.forename: Massimo
authors.initials: M
authors.lastname: Bramucci
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology*; D052160:Benzothiazoles / Q000737:chemistry; D001713:Biphenyl Compounds / Q000737:chemistry; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D006801:Humans; D020902:Hypericum / Q000737:chemistry*; D051379:Mice; D009822:Oils, Volatile / Q000737:chemistry* / Q000494:pharmacology; D010851:Picrates / Q000737:chemistry; D013451:Sulfonic Acids / Q000737:chemistry
chemical_list: D000975:Antioxidants; D052160:Benzothiazoles; D001713:Biphenyl Compounds; D009822:Oils, Volatile; D010851:Picrates; D013451:Sulfonic Acids; C002502:2,2'-azino-di-(3-ethylbenzothiazoline)-6-sulfonic acid; C004931:1,1-diphenyl-2-picrylhydrazyl