title: Signalling the end of the line.
abstract: Cellular senescence is a stable proliferation arrest induced by triggers such as short telomeres, activated oncogenes and genotoxic stress. Two studies show that cellular senescence induced by genotoxic stress depends on chronic DNA-damage signalling from irreparable damage to telomeres. Hence, dysfunctional or damaged telomeres are the initiators of multiple modes of senescence.
authors.forename: John
authors.initials: J
authors.lastname: van Tuyn
authors.forename: Peter D
authors.initials: PD
authors.lastname: Adams
mesh_terms: D000818:Animals; D004249:DNA Damage; D006801:Humans; D016615:Telomere / Q000378:metabolism*