title: Multileaf collimator tracking integrated with a novel x-ray imaging system and external surrogate monitoring.
abstract: We have previously developed a tumour tracking system, which adapts the aperture of a Siemens 160 MLC to electromagnetically monitored target motion. In this study, we exploit the use of a novel linac-mounted kilovoltage x-ray imaging system for MLC tracking. The unique in-line geometry of the imaging system allows the detection of target motion perpendicular to the treatment beam (i.e. the directions usually featuring steep dose gradients). We utilized the imaging system either alone or in combination with an external surrogate monitoring system. We equipped a Siemens ARTISTE linac with two flat panel detectors, one directly underneath the linac head for motion monitoring and the other underneath the patient couch for geometric tracking accuracy assessments. A programmable phantom with an embedded metal marker reproduced three patient breathing traces. For MLC tracking based on x-ray imaging alone, marker position was detected at a frame rate of 7.1 Hz. For the combined external and internal motion monitoring system, a total of only 85 x-ray images were acquired prior to or in between the delivery of ten segments of an IMRT beam. External motion was monitored with a potentiometer. A correlation model between external and internal motion was established. The real-time component of the MLC tracking procedure then relied solely on the correlation model estimations of internal motion based on the external signal. Geometric tracking accuracies were 0.6 mm (1.1 mm) and 1.8 mm (1.6 mm) in directions perpendicular and parallel to the leaf travel direction for the x-ray-only (the combined external and internal) motion monitoring system in spite of a total system latency of ~0.62 s (~0.51 s). Dosimetric accuracy for a highly modulated IMRT beam--assessed through radiographic film dosimetry--improved substantially when tracking was applied, but depended strongly on the respective geometric tracking accuracy. In conclusion, we have for the first time integrated MLC tracking with x-ray imaging in the in-line geometry and demonstrated highly accurate respiratory motion tracking.
authors.affiliation: Department of Medical Physics in Radiation Oncology, German Cancer Research Center-DKFZ, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.
authors.forename: Andreas
authors.initials: A
authors.lastname: Krauss
authors.forename: Martin F
authors.initials: MF
authors.lastname: Fast
authors.forename: Simeon
authors.initials: S
authors.lastname: Nill
authors.forename: Uwe
authors.initials: U
authors.lastname: Oelfke
mesh_terms: D019583:Dose Fractionation, Radiation; D057918:Fiducial Markers; D006801:Humans; D009068:Movement; D009369:Neoplasms / Q000000981:diagnostic imaging* / Q000503:physiopathology / Q000532:radiotherapy*; D011881:Radiotherapy, Computer-Assisted / Q000379:methods* / Q000592:standards; D012119:Respiration; D018511:Systems Integration; D014057:Tomography, X-Ray Computed / Q000379:methods* / Q000592:standards