title: Au-catalyzed asymmetric formal [3 + 2] cycloaddition of isocyanoacetates with maleimides.
abstract: An efficient protocol for the Au(I)-catalyzed asymmetric formal [3 + 2] cycloaddition of isocyanoacetates with phenylmaleimide has been developed. In the presence of cationic Au(I)/DTBM-segphos complex, excellent diastereoselectivity and high levels of enantioselectivity (up to 97% ee) have been attained with a variety of α-substituted isocyanoacetates. The synthetic potential of the resulting enantioenriched 1-pyrrolines has been demonstrated by the preparation of highly substituted pyrrolidines bearing a quaternary stereocenter.
authors.affiliation: Departamento de Química Orgánica, Facultad de Ciencias, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.
authors.forename: Silvia
authors.initials: S
authors.lastname: Padilla
authors.forename: Javier
authors.initials: J
authors.lastname: Adrio
authors.forename: Juan C
authors.initials: JC
authors.lastname: Carretero