title: Study of formulation of pharmaceutical solution form of paracetamol in the pediatric clinical practice.
abstract: AIM of the study was selection of 2 different formulations of paracetamol of 2.5% (125 mg/5 mL) in the Pediatric practice. Paracetamol is widely used in the form of the syrup, with usual percentage of acting ingredient of 125 mg/5 mL.
  
  
  METHODS
  Both samples of the paracetamol syrup were monitored each day regarding organoleptic features (potential changes in color, smell, transparency, crystallization, etc.), whilst in monthly intervals (1 month, 2 months, 3 months, 4 months and 5 months) content of the paracetamol was analyzed, with the spectrophotometric method (HPLC).
  
  
  CONCLUSIONS
  Content of the paracetamol in both syrup formulations has not incurred any change even after a period of 6 months of storage, which showed that these two formulations are appropriate ones. From six different formulations of the paracetamol syrup in percentage of 2.5% (125 mg/5 ml) as more appropriate are: fifth formulation which can be considered, without no doubt, as most appropriate one because of its relatively low cost, an stabilized pH, a quite likeable taste and as such also consequently acceptable in the pediatric practice. In some cases, mainly during the winter, the crystallization of the paracetamol in the lid, walls and bottom of the bottle was ascertained also.
  
  
  CONCLUSIONS
  Syrup of paracetamol 2.5% (125 mg/5 mL) as per the formulation 5 experimented by our side can be recommended as most appropriate to be produced in industrial conditions for purposes of pediatric practice.
authors.affiliation: Department of Pharmacy, Faculty of Medicine, University of Prishtina, Clinical Centre, Prishtina, Kosova.
authors.forename: Bedri
authors.initials: B
authors.lastname: Abdullahu
authors.forename: Vehbi
authors.initials: V
authors.lastname: Shehu
authors.forename: Azem
authors.initials: A
authors.lastname: Lajçi
authors.forename: Hilmi
authors.initials: H
authors.lastname: Islami
mesh_terms: D000082:Acetaminophen / Q000737:chemistry*; D018712:Analgesics, Non-Narcotic / Q000737:chemistry*; D058633:Antipyretics / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D002648:Child; D006801:Humans; D019999:Pharmaceutical Solutions / Q000737:chemistry
chemical_list: D018712:Analgesics, Non-Narcotic; D058633:Antipyretics; D019999:Pharmaceutical Solutions; D000082:Acetaminophen