title: Delivery of a chromosomally normal child from an oocyte with reciprocal aneuploid polar bodies.
abstract: OBJECTIVE
  To demonstrate that a euploid embryo derived from an oocyte with reciprocal aneuploid polar bodies is capable of producing a chromosomally normal child.
  
  
  METHODS
  A case report of maternal MI error compensation where single nucleotide polymorphism (SNP) microarray based comprehensive chromosome screening (CCS) was performed on the 1st and 2nd polar body, the resulting embryo, and newborn DNA.
  
  
  RESULTS
  CCS performed after embryo transfer identified a chromosomally normal embryo that resulted from an oocyte with reciprocal aneuploid polar bodies. The first polar body was found to be missing a single chromatid derived from chromosome 21 and the second polar body possessed an extra chromatid derived from chromosome 21. Compensation of the maternal meiotic error was verified by CCS analysis of a trophectoderm biopsy from the resulting blastocyst which was euploid for all 23 pairs of chromosomes. DNA fingerprinting and CCS of the resulting newborn confirmed a chromosomally normal child, demonstrating the developmental potential of an oocyte with reciprocal aneuploid polar bodies.
  
  
  CONCLUSIONS
  This is the first case report demonstrating the reproductive potential of a chromosomally normal embryo derived from an oocyte which had undergone meiosis I error. Systematic investigation into the frequency of meiosis I error compensation and the negative predictive value of polar body aneuploidy screening for reproductive potential should be conducted in order to confirm clinical relevance.
authors.affiliation: Reproductive Medicine Associates of New Jersey, 111 Madison Ave, Morristown, NJ 07960, USA.
authors.forename: Richard T
authors.initials: RT
authors.lastname: Scott
authors.forename: Nathan R
authors.initials: NR
authors.lastname: Treff
authors.forename: John
authors.initials: J
authors.lastname: Stevens
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Forman
authors.forename: Kathleen H
authors.initials: KH
authors.lastname: Hong
authors.forename: Mandy G
authors.initials: MG
authors.lastname: Katz-Jaffe
authors.forename: William B
authors.initials: WB
authors.lastname: Schoolcraft
mesh_terms: D000328:Adult; D000782:Aneuploidy; D001755:Blastocyst / Q000502:physiology; D002877:Chromosomes, Human; D002891:Chromosomes, Human, Pair 21; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007231:Infant, Newborn; D008540:Meiosis; D009865:Oocytes / Q000502:physiology*; D020641:Polymorphism, Single Nucleotide; D011247:Pregnancy; D019836:Preimplantation Diagnosis / Q000379:methods*; D012016:Reference Values