title: Design, synthesis, and miniemulsion polymerization of new phosphonate surfmers and application studies of the resulting nanoparticles as model systems for biomimetic mineralization and cellular uptake.
abstract: Heterophase polymerizations have gained increasing attention in the past decades, especially as the decoration and functionalization of the particle surface for further applications gets more and more into focus. One promising approach for the functionalization exclusively on the particle surface is the use of surfmers (surfactant and monomer). Herein, we present the synthesis of a new family of surfmers and their use for decorating nanoparticles with phosphonate groups through miniemulsion polymerization. Furthermore the synthesis of a dye-labeled functional surfmer provided an elegant manner to evaluate and get deeper insights about its copolymerization. Additionally, potential applications of the synthesized particles in biological studies as well as their use as template for biomimetic mineralization are presented.
authors.affiliation: Max Planck Institute for Polymer Research, Ackermannweg 10, 55128 Mainz, Germany.
authors.forename: Rüdiger
authors.initials: R
authors.lastname: Sauer
authors.forename: Pablo
authors.initials: P
authors.lastname: Froimowicz
authors.forename: Katrin
authors.initials: K
authors.lastname: Schöller
authors.forename: Jens-M
authors.initials: JM
authors.lastname: Cramer
authors.forename: Sandra
authors.initials: S
authors.lastname: Ritz
authors.forename: Volker
authors.initials: V
authors.lastname: Mailänder
authors.forename: Katharina
authors.initials: K
authors.lastname: Landfester
mesh_terms: D017209:Apoptosis; D032701:Biomimetics; D002460:Cell Line; D004655:Emulsions / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D059630:Mesenchymal Stem Cells; D053758:Nanoparticles / Q000737:chemistry*; D010316:Particle Size; D058105:Polymerization; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry*; D013501:Surface-Active Agents / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D004655:Emulsions; D011108:Polymers; D013501:Surface-Active Agents