title: The biocompatibility of metal-organic framework coatings: an investigation on the stability of SURMOFs with regard to water and selected cell culture media.
abstract: Highly porous thin films based on a [Cu(bdc)(2)](n) (bdc = benzene-1,4-dicarboxylic acid) metal-organic framework, MOF, grown using liquid-phase epitaxy (LPE) show remarkable stability in pure water as well as in artificial seawater. This opens the possibility to use these highly porous coatings for environmental and life science applications. Here we characterize in detail the stability of these SURMOF 2 thin films under aqueous and cell culture conditions. We find that the material degrades only very slowly in water and artificial seawater (ASW) whereas in typical cell culture media (PBS and DMEM) a rapid dissolution is observed. The release of Cu(2+) ions resulting from the dissolution of the SURMOF 2 in the liquids exhibits no adverse effect on the adhesion of fibroblasts, prototype eukaryotic cells, to the substrate and their subsequent proliferation, thus demonstrating the biocompatibility of SURMOF 2 surface coatings. Thus, the results are an important step toward application of these porous materials as a slow release matrix, for example, for pharmaceuticals and growth factors.
authors.affiliation: Institute of Functional Interfaces (IFG), Karlsruhe Institute of Technology, Karlsruhe, Germany.
authors.forename: Maximilian
authors.initials: M
authors.lastname: Hanke
authors.forename: Hasan K
authors.initials: HK
authors.lastname: Arslan
authors.forename: Stella
authors.initials: S
authors.lastname: Bauer
authors.forename: Olexandra
authors.initials: O
authors.lastname: Zybaylo
authors.forename: Christof
authors.initials: C
authors.lastname: Christophis
authors.forename: Hartmut
authors.initials: H
authors.lastname: Gliemann
authors.forename: Axel
authors.initials: A
authors.lastname: Rosenhahn
authors.forename: Christof
authors.initials: C
authors.lastname: Wöll
mesh_terms: D000327:Adsorption; D000818:Animals; D002460:Cell Line; D020099:Coated Materials, Biocompatible / Q000737:chemistry* / Q000633:toxicity; D003300:Copper / Q000737:chemistry; D003470:Culture Media / Q000737:chemistry*; D004355:Drug Stability; D005340:Fibrinogen / Q000737:chemistry / Q000378:metabolism; D049452:Green Fluorescent Proteins / Q000378:metabolism; D009942:Organometallic Compounds / Q000737:chemistry* / Q000633:toxicity; D051381:Rats; D014867:Water / Q000737:chemistry*
chemical_list: D020099:Coated Materials, Biocompatible; D003470:Culture Media; D009942:Organometallic Compounds; D014867:Water; D049452:Green Fluorescent Proteins; D003300:Copper; D005340:Fibrinogen