title: "Possible primary antiphospholipid syndrome" with concurrent diffuse alveolar hemorrhaging and Libman-Sacks endocarditis mimicking catastrophic antiphospholipid syndrome.
abstract: Although antiphospholipid antibody syndrome (APS) is an autoimmune condition that is primarily characterized by arterial or venous thrombosis or pregnancy morbidity and the presence of antiphospholipid antibodies (aPL), recent reviews have introduced non-thromboembolic manifestations. We describe the case of a 58-year-old woman with vegetation on the aortic valve, whose initial presentation of APS abruptly developed into diffuse pulmonary hemorrhage. Despite consecutive plasma exchange procedures and the administration of corticosteroids and high-dose intravenous immunoglobulin, multiple brain infarctions developed, and the patient died of pneumonia. Although anecdotal, this case might serve as a useful example of the non-standard complications of fulminant APS.
authors.affiliation: Department of Rheumatology, Kawakita General Hospital, Japan. akitake.suzuki@gmail.com
authors.forename: Akitake
authors.initials: A
authors.lastname: Suzuki
authors.forename: Naoki
authors.initials: N
authors.lastname: Asazuma
authors.forename: Eigo
authors.initials: E
authors.lastname: Kikuchi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Kawanobe
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Horimoto
authors.forename: Ryuichi
authors.initials: R
authors.lastname: Yokobari
authors.forename: Shigeru
authors.initials: S
authors.lastname: Kotake
authors.forename: Takahiro
authors.initials: T
authors.lastname: Okai
mesh_terms: D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000175:diagnosis*; D003937:Diagnosis, Differential; D004696:Endocarditis / Q000150:complications*; D017809:Fatal Outcome; D005260:Female; D006470:Hemorrhage / Q000150:complications*; D006801:Humans; D008171:Lung Diseases / Q000150:complications*; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008875:Middle Aged