title: Urinalysis-based comparative evaluation of pattern of use of dextropropoxyphene and buprenorphine among opioid-dependent subjects.
abstract: OBJECTIVE
  In view of increasing safety concerns, there is a need to assess benefits of use of dextropropoxyphene as opioid substitution treatment, if any. This study aims at urinalysis-based comparative evaluation of pattern of use of dextropropoxyphene and buprenorphine among opioid-dependent subjects.
  
  
  METHODS
  Laboratory of a tertiary care drug-dependence treatment center.
  
  
  METHODS
  Patients on buprenorphine and dextropropoxyphene therapy and their urinalysis records.
  
  
  METHODS
  Nonexperimental chart review method.
  
  
  METHODS
  "Use," "abuse, "and 'prescribed but not used rates" for buprenorphine and dextropropoxyphene were compared, using chi2-test with level of significance at p < 0.05.
  
  
  RESULTS
  Rate of "use" and "abuse" was significantly high for dextropropoxyphene. Rate of 'prescribed but not used" was significantly high for buprenorphine (p < 0.05).
  
  
  CONCLUSIONS
  Despite apparent benefits of dextropropoxyphene use in terms of better rates of "use" and 'prescribed but not used" as compared to buprenorphine, one needs to review the situation in light of recent reports of adverse effects with dextropropoxyphene and limited resources available.
authors.affiliation: Department of Psychiatry and De-Addiction, Lady Hardinge Medical College and SSK Hospital, New Delhi, India.
authors.forename: Yatan Pal Singh
authors.initials: YP
authors.lastname: Balhara
authors.forename: Raka
authors.initials: R
authors.lastname: Jain
mesh_terms: D000701:Analgesics, Opioid / Q000009:adverse effects / Q000627:therapeutic use / Q000652:urine; D002047:Buprenorphine / Q000627:therapeutic use / Q000652:urine*; D011431:Dextropropoxyphene / Q000627:therapeutic use / Q000652:urine*; D006801:Humans; D055118:Medication Adherence; D058850:Opiate Substitution Treatment / Q000379:methods; D009293:Opioid-Related Disorders / Q000534:rehabilitation*; D015813:Substance Abuse Detection / Q000379:methods*; D016320:Substance Abuse Treatment Centers
chemical_list: D000701:Analgesics, Opioid; D002047:Buprenorphine; D011431:Dextropropoxyphene