title: Complications after percutaneous endoscopic gastrostomy in a prospective study.
abstract: BACKGROUND
  Insertion of a percutaneous endoscopic gastrostomy (PEG) is an increasingly common procedure in patients with nutritional needs and dysphagia. Better knowledge of rates and patterns of complications after PEG might influence decision-making.
  
  
  METHODS
  The objective was to prospectively evaluate the rate of six pre-defined complications (leakage, diarrhea, constipation, abdominal pain, fever and peristomal infection) and mortality occurring within 2 months after PEG in an unselected sample of patients. All patients (n = 484) who had a PEG inserted at the hospital during the study period were included. Kaplan-Meier curves were used to estimate mortality over the first 60 days following PEG and Fisher's exact test was used to test equality of proportions.
  
  
  RESULTS
  Of the 484 patients included, 85 (18%) died within 2 months after PEG insertion. The risk of early mortality was higher in the group with neurological disease than in the group with a tumor as indication (p < 0.001). After excluding mortality, the overall complication rates at 2 weeks and 2 months were 39% and 27%, respectively. The most common complications within 2 weeks were abdominal pain (13%), peristomal infection (11%), diarrhea (11%) and leakage (10%). At 2 months the most frequent complications were diarrhea (10%), leakage (8%) and peristomal infection (6%).
  
  
  CONCLUSIONS
  In the short-term perspective, there is a substantial risk of complications, including mortality, after PEG insertion. This should be considered during clinical decision-making and when informing the patients and caregivers.
authors.affiliation: Department of Molecular Medicine and Surgery, Karolinska Institutet, Upper Gastrointestinal Research, Stockholm, Sweden. john.blomberg@karolinska.se
authors.forename: John
authors.initials: J
authors.lastname: Blomberg
authors.forename: Jesper
authors.initials: J
authors.lastname: Lagergren
authors.forename: Lena
authors.initials: L
authors.lastname: Martin
authors.forename: Fredrik
authors.initials: F
authors.lastname: Mattsson
authors.forename: Pernilla
authors.initials: P
authors.lastname: Lagergren
mesh_terms: D015746:Abdominal Pain / Q000453:epidemiology / Q000209:etiology; D000368:Aged; D003248:Constipation / Q000453:epidemiology / Q000209:etiology; D003967:Diarrhea / Q000453:epidemiology / Q000209:etiology; D005260:Female; D005334:Fever / Q000453:epidemiology / Q000209:etiology; D005500:Follow-Up Studies; D005773:Gastroscopy; D005774:Gastrostomy / Q000379:methods* / Q000401:mortality; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology*; D011446:Prospective Studies; D013530:Surgical Wound Infection / Q000453:epidemiology / Q000209:etiology