title: Optical mapping in the developing zebrafish heart.
abstract: Understanding the developmental basis of cardiac electrical activity has proven technically challenging, largely as a result of the inaccessible nature of the heart during cardiogenesis in many organisms. The emergence of the zebrafish as a model organism has availed the very earliest stages of heart formation to experimental exploration. The zebrafish also offers a robust platform for genetic and chemical screening. These tools have been exploited in screens for modifiers of cardiac electrophysiologic phenotypes and in screens for novel drugs.
authors.affiliation: Brigham and Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA.
authors.forename: M Khaled
authors.initials: MK
authors.lastname: Sabeh
authors.forename: Hussein
authors.initials: H
authors.lastname: Kekhia
authors.forename: Calum A
authors.initials: CA
authors.lastname: Macrae
mesh_terms: D000818:Animals; D055724:Electrophysiological Phenomena; D006321:Heart / Q000254:growth & development / Q000503:physiopathology*; D023421:Models, Animal; D056969:Voltage-Sensitive Dye Imaging / Q000379:methods*; D015027:Zebrafish / Q000254:growth & development / Q000502:physiology*