title: Clinical characteristics and genetic variability of human rhinovirus in Mexico.
abstract: Human rhinovirus (HRV) is a leading cause of acute respiratory infection (ARI) in young children and infants worldwide and has a high impact on morbidity and mortality in this population. Initially, HRV was classified into two species: HRV-A and HRV-B. Recently, a species called HRV-C and possibly another species, HRV-D, were identified. In Mexico, there is little information about the role of HRV as a cause of ARI, and the presence and importance of species such as HRV-C are not known. The aim of this study was to determine the clinical characteristics and genetic variability of HRV in Mexican children. Genetic characterization was carried out by phylogenetic analysis of the 5'-nontranslated region (5'-NTR) of the HRV genome. The results show that the newly identified HRV-C is circulating in Mexican children more frequently than HRV-B but not as frequently as HRV-A, which was the most frequent species. Most of the cases of the three species of HRV were in children under 2 years of age, and all species were associated with very mild and moderate ARI.
authors.affiliation: Instituto de Salud Pública, Universidad Veracruzana, Av. Luis Castelazo Ayala s/n, Col. Industrial Ánimas, 91190, Xalapa, Veracruz, México. nita_18lc@hotmail.com
authors.forename: Adriana
authors.initials: A
authors.lastname: Landa-Cardeña
authors.forename: Jaime
authors.initials: J
authors.lastname: Morales-Romero
authors.forename: Rebeca
authors.initials: R
authors.lastname: García-Roman
authors.forename: Ana Georgina
authors.initials: AG
authors.lastname: Cobián-Güemes
authors.forename: Ernesto
authors.initials: E
authors.lastname: Méndez
authors.forename: Cristina
authors.initials: C
authors.lastname: Ortiz-Leon
authors.forename: Felipe
authors.initials: F
authors.lastname: Pitalúa-Cortés
authors.forename: Silvia Ivonne
authors.initials: SI
authors.lastname: Mora
authors.forename: Hilda
authors.initials: H
authors.lastname: Montero
mesh_terms: D020121:5' Untranslated Regions; D017677:Age Distribution; D002648:Child; D002675:Child, Preschool; D016000:Cluster Analysis; D003139:Common Cold / Q000453:epidemiology / Q000473:pathology* / Q000821:virology*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008800:Mexico / Q000453:epidemiology; D017720:Molecular Epidemiology; D008969:Molecular Sequence Data; D010802:Phylogeny; D012367:RNA, Viral / Q000235:genetics*; D012229:Rhinovirus / Q000145:classification* / Q000235:genetics* / Q000472:pathogenicity; D017422:Sequence Analysis, DNA
chemical_list: D020121:5' Untranslated Regions; D012367:RNA, Viral