title: Safety and efficacy of a quinolone-based regimen for treatment of tuberculosis in renal transplant recipients.
abstract: BACKGROUND
  Rifampin (RFP) is a first-line antituberculosis drug, but it increases the risk of acute rejection (AR) in transplant recipients. This study evaluated whether quinolone (QNL) can replace RFP in renal transplant recipients with tuberculosis.
  
  
  METHODS
  One hundred nine patients with active tuberculosis were included. Patients consisted of RFP (n = 91) and QNL (n = 18) groups based on the initial treatment regimen. Patients with RFP-associated adverse effects were subdivided into RFP-maintenance (RFP-M; n = 18) and QNL-conversion (QNL-C; n = 8) groups. Clinical outcomes were compared between groups.
  
  
  RESULTS
  The incidence of AR was higher in the RFP group than in the QNL group (24.2% vs 5.6%). The QNL group showed significantly higher 10-year graft survival rates than the RFP group (88.1% vs 66.5%; P = .022). The QNL-C group showed significantly higher 10-year graft survival rates than the RFP-M group (87.5% vs 27.8%; P = .011). The rate of complete functional recovery after AR was higher in the QNL-C group than in the RFP-M group (50% vs 22.2%).
  
  
  CONCLUSIONS
  A QNL-based regimen may be safe and effective for treatment of tuberculosis and may lower the risk of graft failure in renal transplant recipients.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Incheon St Mary's Hospital, Catholic University of Korea, Incheon, Korea.
authors.forename: H E
authors.initials: HE
authors.lastname: Yoon
authors.forename: Y J
authors.initials: YJ
authors.lastname: Jeon
authors.forename: H W
authors.initials: HW
authors.lastname: Chung
authors.forename: S J
authors.initials: SJ
authors.lastname: Shin
authors.forename: H S
authors.initials: HS
authors.lastname: Hwang
authors.forename: S J
authors.initials: SJ
authors.lastname: Lee
authors.forename: Y K
authors.initials: YK
authors.lastname: Chang
authors.forename: B S
authors.initials: BS
authors.lastname: Choi
authors.forename: C W
authors.initials: CW
authors.lastname: Park
authors.forename: Y S
authors.initials: YS
authors.lastname: Kim
authors.forename: S Y
authors.initials: SY
authors.lastname: Kim
authors.forename: C W
authors.initials: CW
authors.lastname: Yang
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D015363:Quinolones / Q000627:therapeutic use*; D014376:Tuberculosis / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents; D015363:Quinolones