title: A study on the effects of covered stents on tissue prolapse.
abstract: Polyvinyl alcohol (PVA) cryogel covered stents may reduce complications from thrombosis and restenosis by decreasing tissue prolapse. Finite element analysis was employed to evaluate the effects of PVA cryogel layers of varying thickness on tissue prolapse and artery wall stress for two common stent geometries and two vessel diameters. Additionally, several PVA cryogel covered stents were fabricated and imaged with an environmental scanning electron microscope. Finite element results showed that covered stents reduced tissue prolapse up to 13% and artery wall stress up to 29% with the size of the reduction depending on the stent geometry, vessel diameter, and PVA cryogel layer thickness. Environmental scanning electron microscope images of expanded covered stents showed the PVA cryogel to completely cover the area between struts without gaps or tears. Overall, this work provides both computational and experimental evidence for the use of PVA cryogels in covered stents.
authors.affiliation: Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, GA 30332, USA. jason.weaver@gatech.edu
authors.forename: Jason D
authors.initials: JD
authors.lastname: Weaver
authors.forename: D N
authors.initials: DN
authors.lastname: Ku
mesh_terms: D059985:Cryogels / Q000009:adverse effects; D020342:Finite Element Analysis; D011142:Polyvinyl Alcohol / Q000009:adverse effects; D011391:Prolapse; D015607:Stents / Q000009:adverse effects*
chemical_list: D059985:Cryogels; D011142:Polyvinyl Alcohol