title: Conformationally restricted novel pyrazole derivatives: synthesis of 1,8-disubstituted 5,5-dimethyl-4,5-dihydro-1H-benzo[g]indazoles as a new class of PDE4 inhibitors.
abstract: A number of novel 1,8-disubstituted 5,5-dimethyl-4,5-dihydro-1H-benzo[g]indazoles based on a conformationally restricted pyrazole framework have been designed as potential inhibitors of PDE4. All these compounds were readily prepared by using simple chemistry strategy. The in vitro PDE4B inhibitory properties and molecular modeling studies of some of the compounds synthesized along with the X-ray single crystal data of a representative compound is presented.
authors.affiliation: CiVentiChem (India) Private Limited, Plot No. 72/A, Part 2 Phase-1, IDA Jeedimetla, Hyderabad 500 055, India.
authors.forename: T Shyamsunder
authors.initials: TS
authors.lastname: Reddy
authors.forename: K Shiva
authors.initials: KS
authors.lastname: Kumar
authors.forename: Chandana L T
authors.initials: CL
authors.lastname: Meda
authors.forename: Ajit
authors.initials: A
authors.lastname: Kandale
authors.forename: D
authors.initials: D
authors.lastname: Rambabu
authors.forename: G Rama
authors.initials: GR
authors.lastname: Krishna
authors.forename: C
authors.initials: C
authors.lastname: Hariprasad
authors.forename: V Venugopala
authors.initials: VV
authors.lastname: Rao
authors.forename: S
authors.initials: S
authors.lastname: Venkataiah
authors.forename: C Malla
authors.initials: CM
authors.lastname: Reddy
authors.forename: A
authors.initials: A
authors.lastname: Naidu
authors.forename: P K
authors.initials: PK
authors.lastname: Dubey
authors.forename: Kishore V L
authors.initials: KV
authors.lastname: Parsa
authors.forename: Manojit
authors.initials: M
authors.lastname: Pal
mesh_terms: D018360:Crystallography, X-Ray; D015195:Drug Design; D007191:Indazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008958:Models, Molecular; D008968:Molecular Conformation; D058988:Phosphodiesterase 4 Inhibitors / Q000138:chemical synthesis / Q000737:chemistry*; D011720:Pyrazoles / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D007191:Indazoles; D058988:Phosphodiesterase 4 Inhibitors; D011720:Pyrazoles