title: Synthesis of water-soluble phosphine oxides by Pd/C-catalyzed P-C coupling in water.
abstract: Cross-coupling between diphenylphosphine oxide and halogenated benzoic acids catalyzed by Pd/C in water is a green, simple, and fast protocol to obtain water-soluble tertiary phosphine oxides without the addition of ligands and additives. Low reaction times and microwave irradiation make this method general and excellent for laboratory and large-scale synthesis without the need to use organic solvents in reactions and workup.
authors.affiliation: ETH Zurich, Department of Chemistry and Applied Biosciences, 8093 Zürich, Switzerland.
authors.forename: Stephan M
authors.initials: SM
authors.lastname: Rummelt
authors.forename: Marco
authors.initials: M
authors.lastname: Ranocchiari
authors.forename: Jeroen A
authors.initials: JA
authors.lastname: van Bokhoven