title: Comparative analysis of the impact of α1-and α2-adrenoreceptor blockade on cardiac function in rats during postnatal ontogeny.
abstract: We compared the effects of α1-and α2-adrenoreceptor blockade on cardiac function in rats aged 1, 3, 6 and 20 weeks. Administration of α1-adrenoblocker prazosin decreased heart rate in 20- and 6-week-old rats; in 3-week-old rats, this decrease was insignificant and in 1-week-old rats was absent. Blockade of α2-adrenoreceptors with yohimbine did not change heart rate in 6- and 20-week-old rats and induced bradycardia in 1- and 3-week old rats.
authors.affiliation: Department of Anatomy, Physiology, and Human Health Protection, State Pedagogical University, Kazan, Russia. zefirovtl@mail.ru
authors.forename: T L
authors.initials: TL
authors.lastname: Zefirov
authors.forename: N I
authors.initials: NI
authors.lastname: Ziatdinova
authors.forename: L I
authors.initials: LI
authors.lastname: Khisamieva
authors.forename: A L
authors.initials: AL
authors.lastname: Zefirov
mesh_terms: D058668:Adrenergic alpha-1 Receptor Antagonists / Q000494:pharmacology*; D058647:Adrenergic alpha-2 Receptor Agonists / Q000494:pharmacology*; D000818:Animals; D006339:Heart Rate / Q000187:drug effects; D011224:Prazosin / Q000494:pharmacology*; D051381:Rats; D018340:Receptors, Adrenergic, alpha-1 / Q000378:metabolism*; D018341:Receptors, Adrenergic, alpha-2 / Q000378:metabolism*; D015016:Yohimbine / Q000494:pharmacology*
chemical_list: D058668:Adrenergic alpha-1 Receptor Antagonists; D058647:Adrenergic alpha-2 Receptor Agonists; D018340:Receptors, Adrenergic, alpha-1; D018341:Receptors, Adrenergic, alpha-2; D015016:Yohimbine; D011224:Prazosin