title: Literature survey on epidemiology and pathology of cardiac fibroma.
abstract: BACKGROUND
  Although cardiac fibroma has been regarded as benign tumor, it presents various symptoms and may lead to death. Unfortunately, only a few studies have reported the epidemiology, embryology, and histopathology of the tumor, and the factors predicting poorer outcome are still obscured.
  
  
  METHODS
  In July 2011 we searched for English and Japanese cases of cardiac fibroma using the PubMed and IgakuChuoZasshi databases. We then extracted and sampled raw data from the selected publications in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) style as much as was possible.
  
  
  RESULTS
  Details of a total of 178 patients with cardiac fibroma were retrieved. The mean age was 11.4 years (median: 2.8 years). Tumor sizes ranged from 8.0 to 150.0 mm (mean 53.1 mm). The left ventricle was found to be the most common site associated with the tumor at a rate of 57.3%, followed by the right ventricle, and interventricular septum. The highest mortality was found in patients with septal involvement (58.6%). In all, 111 patients survived among the 160 patients with a recorded outcome. A younger age of the patient at the time of diagnosis was associated with a decreased survival rate. In addition, a significant positive association was found between ages for patients younger than 17 years of age and the diameter of the tumor at the time of diagnosis (r = 0.341, P = 0.006).
  
  
  CONCLUSIONS
  Both the younger age of patients at the time of diagnosis and septal involvement can be regarded as factors significantly indicating a poor prognosis. Furthermore, our statistical analyses support the following hypotheses. First, the high ratio of tumor-to-heart size may generate low cardiac output and therefore lead to poor outcome. Second, the ratio of the sites where cardiac fibroma occurred corresponds with the ratio of the muscular weight of the cardiac chamber. Third, cardiac fibroma involving the interventricular septum more frequently induces conduction system disease.
authors.affiliation: Department of Surgical Pathology, Toho University School of Medicine, 6-11-1 Omori-Nishi, Ota-Ku, Tokyo 143-8541, Japan.
authors.forename: Suguru
authors.initials: S
authors.lastname: Torimitsu
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Nemoto
authors.forename: Megumi
authors.initials: M
authors.lastname: Wakayama
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Okubo
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Yokose
authors.forename: Kanako
authors.initials: K
authors.lastname: Kitahara
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Ozawa
authors.forename: Haruo
authors.initials: H
authors.lastname: Nakayama
authors.forename: Minoru
authors.initials: M
authors.lastname: Shinozaki
authors.forename: Daisuke
authors.initials: D
authors.lastname: Sasai
authors.forename: Takao
authors.initials: T
authors.lastname: Ishiwatari
authors.forename: Kensuke
authors.initials: K
authors.lastname: Takuma
authors.forename: Kazutoshi
authors.initials: K
authors.lastname: Shibuya
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D002675:Child, Preschool; D016208:Databases, Factual; D005260:Female; D005350:Fibroma / Q000453:epidemiology / Q000473:pathology; D006338:Heart Neoplasms / Q000453:epidemiology / Q000473:pathology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D039781:PubMed; D015996:Survival Rate