title: Dihydrochalcone glucosides and antioxidant activity from the roots of Anneslea fragrans var. lanceolata.
abstract: Bioassay-guided fractionation of the roots of Anneslea fragrans var. lanceolata led to the isolation of four dihydrochalcone glucosides, davidigenin-2'-O-(6″-O-4″'-hydroxybenzoyl)-β-glucoside (1), davidigenin-2'-O-(2″-O-4″'-hydroxybenzoyl)-β-glucoside (2), davidigenin-2'-O-(3″-O-4″'-hydroxybenzoyl)-β-glucoside (3), and davidigenin-2'-O-(6″-O-syringoyl)-β-glucoside (4), and 13 known compounds. The structures were identified by means of spectroscopic analysis. Davidigenin-2'-O-(6″-O-syringoyl)-β-glucoside (4), 1-O-3,4-dimethoxy-5-hydroxyphenyl-6-O-(3,5-di-O-methylgalloyl)-β-glucopyranoside (5), lyoniresinol (10), and syringic acid (13) showed ABTS [2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid)] cation radical scavenging activity, with SC(50) values of 52.6 ± 5.5, 26.0 ± 0.7, 6.0 ± 0.2, and 27.5 ± 0.6 μg/mL in 20 min, respectively. Lyoniresinol (10), isofraxidin (12), and syringic acid (13) also showed DPPH [1,1-diphenyl-2-picrylhydrazyl] radical scavenging activity, with SC(50) values of 8.4 ± 1.8, 51.6 ± 2.2, and 4.3 ± 0.7 μg/mL in 30 min, respectively.
authors.affiliation: Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, 807 Taiwan, ROC.
authors.forename: Hung-Yi
authors.initials: HY
authors.lastname: Huang
authors.forename: Horng-Huey
authors.initials: HH
authors.lastname: Ko
authors.forename: Yu-Jin
authors.initials: YJ
authors.lastname: Jin
authors.forename: Sheng-Zehn
authors.initials: SZ
authors.lastname: Yang
authors.forename: You-An
authors.initials: YA
authors.lastname: Shih
authors.forename: Ih-Sheng
authors.initials: IS
authors.lastname: Chen
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000494:pharmacology; D002599:Chalcone / Q000031:analogs & derivatives; D047188:Chalcones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D015394:Molecular Structure; D010851:Picrates / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D013624:Taiwan; D028242:Theaceae / Q000737:chemistry*
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D047188:Chalcones; D016166:Free Radical Scavengers; D005960:Glucosides; D010851:Picrates; C553221:davidigenin; D002599:Chalcone; C004931:1,1-diphenyl-2-picrylhydrazyl; C015812:dihydrochalcone