title: Synthesis, characterization, and anticancer activity of ruthenium-pyrazole complexes.
abstract: A series of new water soluble Ru(III) pyrazole complexes mer-[RuCl(3)(DMSO-S)(pyz)(2)] 1, mer-[RuCl(3)(DMSO-S)(DMSO-O)(pyz)] 2, mer-[RuCl(3)(bpy)(dmpyz)] 3, and mer-[RuCl(3)(DMSO-S)(dmpyz)(2)] 4 (pyz=pyrazole; dmpyz=3,5-dimethylpyrazole, bpy=2,2'-bipyridine) have been synthesized and characterized by use of a combination of spectroscopy (IR and UV-visible), X-ray diffraction, and cyclic voltammetry. The molecular X-ray structure of all reported compounds (1-4) revealed distorted octahedral coordination around ruthenium. The cytotoxicity assay on human breast cancer cells (MCF7) demonstrated that compounds 1 and 4 affect cell viability, whereas compounds 2 and 3 do not show appreciable activity. The IC(50) values for 1 and 4 lie within the range of 71-32μM in MCF7 cells.
authors.affiliation: Department of Chemistry, University of Louisiana at Lafayette, LA 70504, USA. .
authors.forename: Solene
authors.initials: S
authors.lastname: David
authors.forename: Richard S
authors.initials: RS
authors.lastname: Perkins
authors.forename: Frank R
authors.initials: FR
authors.lastname: Fronczek
authors.forename: Sahba
authors.initials: S
authors.lastname: Kasiri
authors.forename: Subhrangsu S
authors.initials: SS
authors.lastname: Mandal
authors.forename: Radhey S
authors.initials: RS
authors.lastname: Srivastava
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D055664:Electrochemical Techniques; D006801:Humans; D020128:Inhibitory Concentration 50; D008958:Models, Molecular; D015394:Molecular Structure; D011720:Pyrazoles / Q000737:chemistry*; D012428:Ruthenium / Q000737:chemistry*; D013053:Spectrophotometry; D014961:X-Ray Diffraction
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D011720:Pyrazoles; C031280:pyrazole; D012428:Ruthenium