title: Effects of Chinese Materia Medica-Fubao Danggui Jiao on experimental endometriosis.
abstract: The objective of this paper was to investigate the effects of a Chinese Materia Medica variant -Fubao Danggui Jiao (FDJ)-on experimental endometriosis. An endometriosis model was created by virtue of auto-transplantation of endometrial tissue onto rats' abdominal walls. The implants were allowed to grow for 30 days until the successful completion of the model. After that, forty endometriotic rats were randomly divided into four study groups and given different treatments: (1) negative control group (water, 2ml/kg, per os); (2) FDJ-A group (FDJ, 2ml/kg, per os); (3) FDJ-B group (FDJ, 4ml/kg, per os); (4) Danazol group (70mg/kg, per os). After 30 days with treatments, the volumes of endometriotic implants in each rat were measured. The implants and normal uterine horns were removed for routine histological examination. FDJ caused significant decreases in volumes of the surviving endometriotic implants, with two different doses having statistically equivalent effects. Upon histological examination, FDJ was observed to cause regression of epithelium and stroma of endometriotic implants. FDJ had revealed promising therapeutic effects on endometriosis.
authors.affiliation: Department of Pharmacy, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. sunxing10wy@yahoo.cn
authors.forename: Xing
authors.initials: X
authors.lastname: Sun
authors.forename: Lijue
authors.initials: L
authors.lastname: Chen
authors.forename: Fanbo
authors.initials: F
authors.lastname: Zeng
mesh_terms: D034861:Abdominal Wall / Q000473:pathology; D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004715:Endometriosis / Q000188:drug therapy* / Q000473:pathology; D004717:Endometrium / Q000187:drug effects* / Q000473:pathology; D005260:Female; D008419:Materia Medica / Q000494:pharmacology / Q000627:therapeutic use*; D008516:Medicine, Chinese Traditional; D008517:Phytotherapy; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D016896:Treatment Outcome; D014599:Uterus / Q000473:pathology
chemical_list: D008419:Materia Medica