title: Subungual melanoma of the great toe in a Hispanic male with Down syndrome: a case report and review of the literature.
abstract: Solid mass tumors are not as common as leukemia in individuals with Down syndrome. In this report, we describe the rare case of an adult Hispanic male with Down syndrome who developed advanced subungual melanoma in the hallux. We also describe the course of treatment, which involved hallux amputation along with metastatic work-up and sentinel lymph node biopsy with eventual resection.
authors.affiliation: Resident, Department of Podiatry, New York College of Podiatric Medicine/Metropolitan Hospital, New York, NY, USA.
authors.forename: Christina
authors.initials: C
authors.lastname: Kwok-Oleksy
authors.forename: Manijeh
authors.initials: M
authors.lastname: Berenji
authors.forename: Nicholas G
authors.initials: NG
authors.lastname: Argerakis
authors.forename: Michael
authors.initials: M
authors.lastname: Trepal
authors.forename: Marc K
authors.initials: MK
authors.lastname: Wallack
mesh_terms: D000671:Amputation, Surgical; D004314:Down Syndrome / Q000150:complications*; D005500:Follow-Up Studies; D006214:Hallux / Q000601:surgery*; D006801:Humans; D008198:Lymph Nodes / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008545:Melanoma / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D008875:Middle Aged; D011877:Radionuclide Imaging; D021701:Sentinel Lymph Node Biopsy; D014034:Toes