title: Efficient construction of fused indolines with a 2-quaternary center via an intramolecular Heck reaction with a low catalyst loading.
abstract: An efficient construction of fused indolines with a 2-quaternary center through a palladium-catalyzed intramolecular Heck reaction of N-(2(2-halobenzoxyl)-2,3-disubstituted indoles is disclosed. This protocol provided a straightforward access to diverse fused indolines with good functional group tolerance.
authors.affiliation: State Key Laboratory of Natural Medicines and Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, PR China.
authors.forename: Lei
authors.initials: L
authors.lastname: Zhao
authors.forename: Ziyuan
authors.initials: Z
authors.lastname: Li
authors.forename: Lin
authors.initials: L
authors.lastname: Chang
authors.forename: Jinyi
authors.initials: J
authors.lastname: Xu
authors.forename: Hequan
authors.initials: H
authors.lastname: Yao
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Wu
mesh_terms: D002384:Catalysis; D003500:Cyclization; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
chemical_list: D007211:Indoles; D010165:Palladium; C057812:indoline