title: Pathological effects of dichlorvos and fenitrothion in mice.
abstract: Seeds of faba and soybeans were treated with dichlorvos (12 mg/kg) and fenitrothion (5 mg/kg) insecticides and stored for 30 weeks. The total internal residues of dichlorvos and fenitrothion amounted to about 69%, 73% and 67%, 74% in the applied doses in faba and soybeans, respectively. The pathological potential of dichlorvos and fenitrothion residues was studied by feeding mice for 90 days with the treated seeds. Parallel studies were conducted in two control groups. Liver and kidney were taken for histological examinations. The results of blood biochemistry are supported by the histopathological changes observed in the liver and kidney of treated mice. Dichlorvos and fenitrothion insecticides caused degenerative changes in the liver and kidney of mice. Changes were more intense in mice which were given beans treated with dichlorvos than in mice fed on beans treated with fenitrothion. The livers of both treated groups showed an abnormal size and shape of hepatic cells. The kidneys of treated mice showed tubular vascular degeneration and lumen dilatation in both groups as compared with the control group.
authors.affiliation: Department of Applied Organic Chemistry, National Research Centre, Dokki, Giza, Egypt. somiaibrahem@yahoo.com
authors.forename: El-Maghraby
authors.initials: el-M
authors.lastname: Somia
authors.forename: Farghaly
authors.initials: F
authors.lastname: Madiha
mesh_terms: D000284:Administration, Oral; D000821:Animal Feed / Q000032:analysis; D000818:Animals; D004006:Dichlorvos / Q000032:analysis / Q000633:toxicity*; D005278:Fenitrothion / Q000032:analysis / Q000633:toxicity*; D005506:Food Contamination / Q000032:analysis*; D022781:Hepatocytes / Q000187:drug effects / Q000473:pathology; D007306:Insecticides / Q000032:analysis / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D007684:Kidney Tubules / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D051379:Mice; D010573:Pesticide Residues / Q000032:analysis; D010936:Plant Extracts / Q000737:chemistry; D012639:Seeds / Q000737:chemistry; D013025:Glycine max / Q000737:chemistry; D018675:Toxicity Tests; D031307:Vicia faba / Q000737:chemistry
chemical_list: D007306:Insecticides; D010573:Pesticide Residues; D010936:Plant Extracts; D004006:Dichlorvos; D005278:Fenitrothion