title: Peptidolipins B-F, antibacterial lipopeptides from an ascidian-derived Nocardia sp.
abstract: A marine Nocardia sp. isolated from the ascidian Trididemnum orbiculatum was found to produce five new lipopeptides, peptidolipins B-F (1-5), which show distinct similarities to the previously reported L-Val(6) analog of peptidolipin NA. Synthetic modification of peptidolipin E (4) was used to determine the location of an olefin within the lipid chain. The advanced Marfey's method was used to determine the absolute configurations of the amino acids. Peptidolipins B (1) and E (4) demonstrated moderate antibacterial activity against methicillin-resistant Staphylococcus aureus and methicillin-sensitive Staphylococcus aureus.
authors.affiliation: Pharmaceutical Sciences Division, University of Wisconsin-Madison, 777 Highland Avenue, Madison, Wisconsin 53705, USA.
authors.forename: Thomas P
authors.initials: TP
authors.lastname: Wyche
authors.forename: Yanpeng
authors.initials: Y
authors.lastname: Hou
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Vazquez-Rivera
authors.forename: Doug
authors.initials: D
authors.lastname: Braun
authors.forename: Tim S
authors.initials: TS
authors.lastname: Bugni
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D055666:Lipopeptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D008386:Marine Biology; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009615:Nocardia / Q000737:chemistry*; D014561:Urochordata / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents; D055666:Lipopeptides; C025801:peptidolipin NA