title: Alternative mitochondrial fuel extends life span.
abstract: In this issue of Cell Metabolism, Ristow and colleagues (Zarse et al., 2012) elucidate a conserved mechanism through which reduced insulin-IGF1 signaling activates an AMP-kinase-driven metabolic shift toward oxidative proline metabolism. This, in turn, produces an adaptive mitochondrial ROS signal that extends worm life span. These findings further bolster the concept of mitohormesis as a critical component of conserved aging and longevity pathways.
authors.affiliation: Departments of Pathology and Genetics, Yale University School of Medicine, New Haven, CT 06520-8023, USA.
authors.forename: Elizabeth A
authors.initials: EA
authors.lastname: Schroeder
authors.forename: Gerald S
authors.initials: GS
authors.lastname: Shadel