title: Adhesion molecules close homolog of L1 and tenascin-C affect blood-spinal cord barrier repair.
abstract: Mice deficient in the recognition molecules, close homolog of L1 (CHL1) and tenascin-C, show improved and reduced functional recovery, respectively, after spinal cord injury compared with wild-type littermates. In this study, we addressed the question whether the differential functional outcome was paralleled by differences in blood-spinal cord barrier (BSCB) repair in the two mouse strains. We conducted spinal cord compression injuries in knock-out and wild-type mice. BSCB permeability was assessed by measuring the Evans blue spread within the spinal cord tissue at 14-21 days after injury. Results show that CHL1 reduces and tenascin-C enhances BSCB permeability, suggesting a correlation between functional outcome and BSCB repair.
authors.affiliation: Department of Cell Biology and Neuroscience, W.M. Keck Center for Collaborative Neuroscience, Rutgers, The State University of New Jersey, New Jersey, USA.
authors.forename: Nicole R
authors.initials: NR
authors.lastname: Peter
authors.forename: Ronak T
authors.initials: RT
authors.lastname: Shah
authors.forename: Jian
authors.initials: J
authors.lastname: Chen
authors.forename: Andrey
authors.initials: A
authors.lastname: Irintchev
authors.forename: Melitta
authors.initials: M
authors.lastname: Schachner
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D015815:Cell Adhesion Molecules / Q000172:deficiency / Q000378:metabolism*; D004195:Disease Models, Animal; D005070:Evans Blue; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D055806:Microvessels / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D010539:Permeability; D020127:Recovery of Function / Q000235:genetics*; D013116:Spinal Cord / Q000378:metabolism; D013119:Spinal Cord Injuries / Q000473:pathology / Q000503:physiopathology*; D058630:Spinal Cord Regeneration / Q000235:genetics*; D019063:Tenascin / Q000172:deficiency / Q000378:metabolism*; D013997:Time Factors
chemical_list: D015815:Cell Adhesion Molecules; C490649:Chl1 protein, mouse; D019063:Tenascin; D005070:Evans Blue