title: Sector laser photocoagulation for the prevention of macular edema after plaque radiotherapy for uveal melanoma: a pilot study.
abstract: OBJECTIVE
  To investigate the role of sector laser photocoagulation for prevention of macular edema after plaque radiotherapy for uveal melanoma.
  
  
  METHODS
  Noncomparative, pilot interventional case series. The main outcome measure was optical coherence tomography-evident macular edema.
  
  
  RESULTS
  A total of 29 patients had sector laser photocoagulation (sector panretinal photocoagulation) and sub-Tenon triamcinolone injection. The median tumor thickness and base was 3.3 mm and 10.0 mm. The median radiation dose and rate to the macula was 2,944 cGy and 31.0 cGy/hour. At the 12-month and 24-months follow-up, cystoid macular edema was found in 17% and 24% of the sector panretinal photocoagulation group. There were no major side effects registered.
  
  
  CONCLUSIONS
  Sector panretinal photocoagulation in combination with sub-Tenon triamcinolone appears to show potential as a safe and beneficial intervention for the prevention of macular edema after plaque radiotherapy for uveal melanoma in this series.
authors.affiliation: Ocular Oncology Service, Wills Eye Institute, Thomas Jefferson University, Philadelphia, Pennsylvania, USA. miguel.materin@yale.edu
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Materin
authors.forename: Carlos G
authors.initials: CG
authors.lastname: Bianciotto
authors.forename: Chengqing
authors.initials: C
authors.lastname: Wu
authors.forename: Carol L
authors.initials: CL
authors.lastname: Shields
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy / Q000009:adverse effects*; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000008:administration & dosage; D006801:Humans; D017075:Laser Coagulation; D008266:Macula Lutea / Q000528:radiation effects*; D008269:Macular Edema / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control*; D008297:Male; D008545:Melanoma / Q000532:radiotherapy*; D008875:Middle Aged; D010865:Pilot Projects; D011832:Radiation Injuries / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control*; D011879:Radiotherapy Dosage; D041623:Tomography, Optical Coherence; D014222:Triamcinolone Acetonide / Q000008:administration & dosage; D014604:Uveal Neoplasms / Q000532:radiotherapy*
chemical_list: D005938:Glucocorticoids; D014222:Triamcinolone Acetonide