title: Implantable continuous-flow right ventricular assist device: lessons learned in the development of a cleveland clinic device.
abstract: Although the need for right ventricular assist device (RVAD) support for right ventricular failure after the implantation of a continuous-flow left ventricular assist device has decreased, right ventricular failure still occurs in as many as 44% of patients after continuous-flow left ventricular assist device insertion. Cleveland Clinic's DexAide continuous-flow RVAD was implanted in 34 calves during the course of its development. This review discusses lessons learned in the design and development of an implantable continuous-flow RVAD that are drawn from the results of these in vivo studies, our clinical experience with RVAD support, and a review of previously published reports on clinical RVAD use.
authors.affiliation: Department of Biomedical Engineering, Lerner Research Institute, Cleveland, Ohio 44195, USA. fukamak@ccf.org
authors.forename: Kiyotaka
authors.initials: K
authors.lastname: Fukamachi
authors.forename: Akira
authors.initials: A
authors.lastname: Shiose
authors.forename: Alex L
authors.initials: AL
authors.lastname: Massiello
authors.forename: David J
authors.initials: DJ
authors.lastname: Horvath
authors.forename: Leonard A R
authors.initials: LA
authors.lastname: Golding
authors.forename: Sangjin
authors.initials: S
authors.lastname: Lee
authors.forename: Randall C
authors.initials: RC
authors.lastname: Starling
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000627:therapeutic use; D004195:Disease Models, Animal; D004867:Equipment Design; D004868:Equipment Failure; D004869:Equipment Safety; D005260:Female; D006333:Heart Failure / Q000401:mortality / Q000503:physiopathology / Q000601:surgery; D006353:Heart-Assist Devices; D006801:Humans; D008297:Male; D020380:Needs Assessment; D009820:Ohio; D011379:Prognosis; D019919:Prosthesis Implantation; D011673:Pulsatile Flow / Q000502:physiology; D018570:Risk Assessment; D016019:Survival Analysis; D013923:Thromboembolism / Q000188:drug therapy / Q000503:physiopathology; D018497:Ventricular Dysfunction, Right / Q000503:physiopathology / Q000601:surgery*
chemical_list: D000925:Anticoagulants