title: Synthesis, characterization and biological activity of ferrocene-based Schiff base ligands and their metal (II) complexes.
abstract: Metal (II) complexes derived from S-benzyl-N-(1-ferrocenyl-3-(4-methylbenzene)acrylketone) dithiocarbazate; HL(1), S-benzyl-N-(1-ferrocenyl-3-(4-chlorobenzene)acrylketone)dithiocarbazate; HL(2), all the compounds were characterized using various spectroscopic techniques. The molar conductance data revealed that the chelates were non-electrolytes. IR spectra showed that the Schiff bases were coordinated to the metal ions in a bidentate manner with N, S donor sites. The ligands and their metal complexes have been screened for in vitro antibacterial, antifungal properties. The result of these studies have revealed that zinc (II) complexes 6 and 13 of both the ligands and copper (II) complexes 9 of the HL(2) were observed to be the most active against all bacterial strains, antifungal activity was overall enhanced after complexation of the ligands.
authors.affiliation: Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry, Ministry of Education, Shaanxi University of Science & Technology, Xi'an, Shaanxi 710021, PR China. lyt@sust.edu.cn
authors.forename: Yu-Ting
authors.initials: YT
authors.lastname: Liu
authors.forename: Gui-Dan
authors.initials: GD
authors.lastname: Lian
authors.forename: Da-Wei
authors.initials: DW
authors.lastname: Yin
authors.forename: Bao-Jun
authors.initials: BJ
authors.lastname: Su
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D004553:Electric Conductivity; D005296:Ferrous Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D000075163:Metallocenes; D008826:Microbial Sensitivity Tests; D012545:Schiff Bases / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013237:Stereoisomerism
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D056831:Coordination Complexes; D005296:Ferrous Compounds; D008024:Ligands; D000075163:Metallocenes; D012545:Schiff Bases; C004998:ferrocene