title: On sharing quantitative trait GWAS results in an era of multiple-omics data and the limits of genomic privacy.
abstract: Recent advances in genome-scale, system-level measurements of quantitative phenotypes (transcriptome, metabolome, and proteome) promise to yield unprecedented biological insights. In this environment, broad dissemination of results from genome-wide association studies (GWASs) or deep-sequencing efforts is highly desirable. However, summary results from case-control studies (allele frequencies) have been withdrawn from public access because it has been shown that they can be used for inferring participation in a study if the individual's genotype is available. A natural question that follows is how much private information is contained in summary results from quantitative trait GWAS such as regression coefficients or p values. We show that regression coefficients for many SNPs can reveal the person's participation and for participants his or her phenotype with high accuracy. Our power calculations show that regression coefficients contain as much information on individuals as allele frequencies do, if the person's phenotype is rather extreme or if multiple phenotypes are available as has been increasingly facilitated by the use of multiple-omics data sets. These findings emphasize the need to devise a mechanism that allows data sharing that will facilitate scientific progress without sacrificing privacy protection.
authors.affiliation: Department of Health Studies, University of Chicago, Chicago, IL, 60637, USA. haky@uchicago.edu
authors.forename: Hae Kyung
authors.initials: HK
authors.lastname: Im
authors.forename: Eric R
authors.initials: ER
authors.lastname: Gamazon
authors.forename: Dan L
authors.initials: DL
authors.lastname: Nicolae
authors.forename: Nancy J
authors.initials: NJ
authors.lastname: Cox
mesh_terms: D005260:Female; D005787:Gene Frequency; D055106:Genome-Wide Association Study / Q000941:ethics*; D023281:Genomics / Q000941:ethics; D006801:Humans; D033181:Information Dissemination / Q000941:ethics*; D008297:Male; D055432:Metabolomics / Q000941:ethics; D018907:Privacy; D040901:Proteomics / Q000941:ethics; D040641:Quantitative Trait Loci; D059467:Transcriptome