title: Immunization strategies against henipaviruses.
abstract: Hendra virus and Nipah virus are recently discovered and closely related emerging viruses that now comprise the genus henipavirus within the sub-family Paramyxoviridae and are distinguished by their broad species tropism and in addition to bats can infect and cause fatal disease in a wide variety of mammalian hosts including humans. The high mortality associated with human and animal henipavirus infections has highlighted the importance and necessity of developing effective immunization strategies. The development of suitable animal models of henipavirus infection and pathogenesis has been critical for testing the efficacy of potential therapeutic approaches. Several henipavirus challenge models have been used and recent successes in both active and passive immunization strategies against henipaviruses have been reported which have all targeted the viral envelope glycoproteins.
authors.affiliation: Department of Microbiology and Immunology, Uniformed Services University, Bethesda, MD 20814, USA. cbroder@usuhs.mil
authors.forename: Christopher C
authors.initials: CC
authors.lastname: Broder
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Geisbert
authors.forename: Kai
authors.initials: K
authors.lastname: Xu
authors.forename: Dimitar B
authors.initials: DB
authors.lastname: Nikolov
authors.forename: Lin-Fa
authors.initials: LF
authors.lastname: Wang
authors.forename: Deborah
authors.initials: D
authors.lastname: Middleton
authors.forename: Jackie
authors.initials: J
authors.lastname: Pallister
authors.forename: Katharine N
authors.initials: KN
authors.lastname: Bossart
mesh_terms: D000818:Animals; D000906:Antibodies / Q000008:administration & dosage / Q000276:immunology; D045404:Hendra Virus / Q000276:immunology* / Q000472:pathogenicity; D045464:Henipavirus Infections / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*; D006801:Humans; D007116:Immunization, Passive; D045405:Nipah Virus / Q000276:immunology* / Q000472:pathogenicity; D014611:Vaccination; D022223:Vaccines, Subunit; D014614:Vaccines, Synthetic; D014759:Viral Envelope Proteins / Q000008:administration & dosage / Q000096:biosynthesis / Q000276:immunology*; D056189:Viral Tropism; D014765:Viral Vaccines / Q000008:administration & dosage / Q000096:biosynthesis / Q000276:immunology*
chemical_list: D000906:Antibodies; D022223:Vaccines, Subunit; D014614:Vaccines, Synthetic; D014759:Viral Envelope Proteins; D014765:Viral Vaccines