title: An atypical case of islet cell hyperplasia in a Wistar rat.
abstract: The present article describes an unusual proliferative islet finding observed incidentally in a young male Wistar rat in a 2-week toxicity study. Histologically, the islet lesion was characterized by diffuse enlargement of the islets, which consisted of peripheral proliferation of non-insulin-containing islet cells surrounding normal-appearing insulin-containing cells in the center. To the authors' knowledge, this is the first report of spontaneous proliferative islet lesion composed of non-insulin-containing cells in young rats.
authors.affiliation: Pfizer Global Research and Development, Groton, Connecticut, USA. norimitsu.shirai@pfizer.com
authors.forename: Norimitsu
authors.initials: N
authors.lastname: Shirai
authors.forename: Alexandros
authors.initials: A
authors.lastname: Papanikolaou
authors.forename: Rick
authors.initials: R
authors.lastname: Perry
mesh_terms: D000073738:2-Hydroxypropyl-beta-cyclodextrin; D000818:Animals; D001786:Blood Glucose; D049109:Cell Proliferation; D005260:Female; D006965:Hyperplasia / Q000473:pathology*; D007279:Injections, Subcutaneous; D007328:Insulin / Q000097:blood; D007515:Islets of Langerhans / Q000166:cytology / Q000473:pathology*; D008297:Male; D010949:Plasma / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D047392:beta-Cyclodextrins / Q000008:administration & dosage
chemical_list: D001786:Blood Glucose; D007328:Insulin; D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin