title: Intramolecular oxycyanation of alkenes by cooperative Pd/BPh3 catalysis.
abstract: The cooperative catalysis by palladium and triphenylborane effects the intramolecular oxycyanation of alkenes through the cleavage of O-CN bonds and the subsequent insertion of double bonds. The use of 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (Xantphos) as a ligand for palladium is essential for allowing the transformation to proceed with high chemo- and regioselectivity. Variously substituted dihydrobenzofurans with both a tetra-substituted carbon and cyano functionality are accessed by the newly developed methodology.
authors.affiliation: Institut für Organische und Biomolekulare Chemie, Georg-August-Universität Göttingen, Tammannstrasse 2, D-37077 Göttingen, Germany.
authors.forename: Dennis C
authors.initials: DC
authors.lastname: Koester
authors.forename: Masato
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Daniel B
authors.initials: DB
authors.lastname: Werz
authors.forename: Yoshiaki
authors.initials: Y
authors.lastname: Nakao
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D002384:Catalysis; D003485:Cyanates / Q000737:chemistry*; D008722:Methods; D010165:Palladium / Q000737:chemistry; D010720:Phosphines; D014966:Xanthenes
chemical_list: D000475:Alkenes; D003485:Cyanates; D010720:Phosphines; D014966:Xanthenes; D010165:Palladium; C519861:xantphos