title: Inflammation-related gene expression profiles of endocervical polyps.
abstract: The roles of inflammation-associated genes in the pathogenesis of endocervical polyps remain unclear. We thus compared the expression levels of 509 inflammation-associated genes between endocervical polyp tissues and endocervical canal membrane tissues using a gene microarray. Sixteen inflammation-related genes were differentially expressed in endocervical polyps compared with those of normal endocervical canal membrane tissues. Expression of 8 of these 16 genes was further validated biochemically. The protein expression levels of IL-12P40, IL-17, IFN-γ, TNF-α, CCR2, and IL-11 were significantly higher in endocervical polyps than those in endocervical canal tissues, while expression of TGF-β1 and IL-10 was significantly lower (P<0.05). In addition, endocervical polyp tissues expressed IL-12P40, IL-17, IFN-γ, TNF-α, CCR2, IL-11, TGF-β1, and IL-10 mainly in the cytoplasm of the inflammatory cells and, to a lesser extent, in the acinus of the serous gland. Endocervical polyp is a polygenic disease and aberrantly expressed genes may play roles in its pathogenesis.
authors.affiliation: Department of Obstetrics and Gynecology, the First Affiliated Hospital of Harbin Medical University, Harbin, China.
authors.forename: Yinglan
authors.initials: Y
authors.lastname: Liu
authors.forename: Yaling
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jianhuan
authors.initials: J
authors.lastname: Fu
authors.forename: Wenhua
authors.initials: W
authors.lastname: Tan
mesh_terms: D000328:Adult; D000368:Aged; D002584:Cervix Uteri / Q000276:immunology*; D016207:Cytokines / Q000235:genetics* / Q000276:immunology; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007249:Inflammation / Q000235:genetics*; D018836:Inflammation Mediators / Q000276:immunology; D046228:Microarray Analysis; D008875:Middle Aged; D011127:Polyps / Q000235:genetics* / Q000276:immunology; D018121:Receptors, Cytokine / Q000235:genetics / Q000378:metabolism; D002583:Uterine Cervical Neoplasms / Q000235:genetics / Q000276:immunology; D055815:Young Adult
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators; D018121:Receptors, Cytokine