title: A comparative study of antioxidant system and intensity of lipid peroxidation in type 2 diabetes mellitus and ischemic stroke aggravated and not aggravated by type 2 diabetes mellitus.
abstract: The survey was conducted on patients with type 2 diabetes mellitus and on patients with ischemic stroke aggravated and not aggravated by type 2 diabetes mellitus. A comparative study of the function of antioxidant system and the intensity of oxidative stress induced by lipid peroxidation (LPO) in the blood was carried out. Stroke aggravated by diabetes was characterized by higher intensity of LPO than stroke not aggravated by diabetes, which, apparently, determines the more severe course of stroke in patients with diabetes. The mechanisms of compensatory response to oxidative stress at the level of antioxidants in stroke aggravated by diabetes also differed from those in stroke not aggravated by diabetes. These data indicate the need of using water-soluble low-molecular-weight antioxidants in the treatment of stroke aggravated by diabetes.
authors.affiliation: Institute of Molecular Biology, National Academy of Sciences of the Republic of Armenia, Yerevan, Armenia.
authors.forename: G V
authors.initials: GV
authors.lastname: Tsakanova
authors.forename: V A
authors.initials: VA
authors.lastname: Ayvazyan
authors.forename: A S
authors.initials: AS
authors.lastname: Boyajyan
authors.forename: E A
authors.initials: EA
authors.lastname: Arakelova
authors.forename: G S
authors.initials: GS
authors.lastname: Grigoryan
authors.forename: A A
authors.initials: AA
authors.lastname: Guevorkyan
authors.forename: A A
authors.initials: AA
authors.lastname: Mamikonyan
mesh_terms: D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D002545:Brain Ischemia / Q000097:blood* / Q000150:complications / Q000201:enzymology; D016022:Case-Control Studies; D002570:Ceruloplasmin / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications / Q000201:enzymology; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D018709:Statistics, Nonparametric
chemical_list: D000975:Antioxidants; D008054:Lipid Peroxides; D002570:Ceruloplasmin