title: Comparative analysis of the effects of various stress factors at the stage of early organogenesis on heart rate variability in pregnant female rats and their offspring.
abstract: We studied changes in the autonomic balance of heart regulation (by the parameters of heart rate variability) in non-pregnant female rats and rats on the days 10-11 of pregnancy on the next day after stress provoked by acute hypobaric hypoxia, intermittent normobaric hypoxia, or immobilization. The same parameters were assessed in 36-day-old offspring. In non-pregnant rats, the intermittent hypoxia resulted in a shift of the autonomic balance of heart regulation towards activation of the parasympathetic nervous system; in pregnant females, immobilization led to a shift of the autonomic balance towards the sympathetic nervous system. In the offspring, the changes also depended on the type of stress.
authors.affiliation: Department of Human and Animal Physiology, Department of Biophysics, Biological Faculty, M. V. Lomonosov Moscow State University, Russia.
authors.forename: T Yu
authors.initials: TY
authors.lastname: Dunaeva
authors.forename: M V
authors.initials: MV
authors.lastname: Maslova
authors.forename: L K
authors.initials: LK
authors.lastname: Trofimova
authors.forename: A V
authors.initials: AV
authors.lastname: Graf
authors.forename: A S
authors.initials: AS
authors.lastname: Maklakova
authors.forename: Ya V
authors.initials: YV
authors.lastname: Krushinskaya
authors.forename: E E
authors.initials: EE
authors.lastname: Chirazova
authors.forename: N A
authors.initials: NA
authors.lastname: Sokolova
mesh_terms: D000818:Animals; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D000860:Hypoxia / Q000503:physiopathology; D038081:Organogenesis / Q000502:physiology*; D011247:Pregnancy; D051381:Rats; D012149:Restraint, Physical / Q000502:physiology; D013312:Stress, Physiological / Q000502:physiology*