title: Cholesteryl Ester Transfer Protein (CETP) genotype and cognitive function in persons aged 35 years or older.
abstract: Common polymorphisms of the Cholestryl Ester Transfer Protein (CETP) gene may predict lower risk of cognitive decline. We investigated the association of cognitive function with CETP genotype in a population-based cohort of 4135 persons aged 35-82 years. Cognitive function was measured with the Ruff Figural Fluency Test (RFFT; worst score, 0 points; best score, 175 points) and CETP I405V and Taq1B genotypes were determined by polymerase chain reaction. RFFT score was not associated with I405V genotype in persons aged 35-64 years. Remarkably, beyond age 65, homozygous valine carriers had higher RFFT scores than heterozygous carriers and noncarriers: RFFT (SD), 52 (21), 49 (18), and 47 (17) points, respectively (p = 0.005). There also was a statistically significant interaction between I405V genotype and age. Beyond age 65, the difference between homozygous valine carriers and noncarriers increased by 0.11 point per year (p = 0.005). RFFT score was not associated with Taq1B genotype. In conclusion, CETP I405V valine homozygosity was associated with better cognitive function in persons aged 65 years or older.
authors.affiliation: University Center for Geriatric Medicine, University of Groningen, Univerity Medical Center Groningen, Groningen, the Netherlands. g.j.izaks@umcg.nl
authors.forename: Gerbrand J
authors.initials: GJ
authors.lastname: Izaks
authors.forename: Aafke M
authors.initials: AM
authors.lastname: van der Knaap
authors.forename: Ron T
authors.initials: RT
authors.lastname: Gansevoort
authors.forename: Gerjan
authors.initials: G
authors.lastname: Navis
authors.forename: Joris P J
authors.initials: JP
authors.lastname: Slaets
authors.forename: Robin P F
authors.initials: RP
authors.lastname: Dullaart
mesh_terms: D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000235:genetics*; D053480:Cholesterol Ester Transfer Proteins / Q000235:genetics*; D003071:Cognition; D003072:Cognition Disorders / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000453:epidemiology* / Q000235:genetics*; D014644:Genetic Variation / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D015995:Prevalence; D012307:Risk Factors
chemical_list: C506642:CETP protein, human; D053480:Cholesterol Ester Transfer Proteins; D005819:Genetic Markers