title: Evaluation of the anti-inflammatory and antinociceptive properties of p-cymene in mice.
abstract: We attempted to identify the antinociceptive and anti-inflammatory actions of the monoterpene p-cymene. Firstly, behavioural screening was carried out to verify the influence of p-cymene [25, 50, and 100 mg/kg intraperitoneal (i.p.)] on the central nervous system (CNS) activity. The antinociceptive activity of p-cymene was evaluated by the acetic acid-induced writhing response, formalin, and hot-plate test, respectively. The leukocyte migration induced by injection of carrageenan was used to assess the anti-inflammatory activity. p-Cymene showed depressant activity on CNS after 4 h of treatment and also a possible action on the autonomous nervous system (ANS), mainly at the dose of 100 mg/kg (i.p.). It was found that p-cymene (50 and 100 mg/kg, i.p.) significantly (p < 0.05) reduced the writhing responses induced by acetic acid. p-Cymene also decreased the licking time in the first and second phase, respectively, of the formalin test. The results of the hot-plate test showed that all doses of p-cymene increased significantly the latency time of the response to the thermal stimulus in both licking and jumping parameters. In addition, there was a significantly (p < 0.05) decreased leukocyte migration at all doses of p-cymene. The experimental data demonstrate that p-cymene possesses antinociceptive and anti-inflammatory activities.
authors.affiliation: Department of Physiology, Universidade Federal de Sergipe (DFS/UFS), Aracaju, SE, Brazil. lbonjardim@yahoo.com.br
authors.forename: Leonardo R
authors.initials: LR
authors.lastname: Bonjardim
authors.forename: Edisleide S
authors.initials: ES
authors.lastname: Cunha
authors.forename: Adriana G
authors.initials: AG
authors.lastname: Guimarães
authors.forename: Michele F
authors.initials: MF
authors.lastname: Santana
authors.forename: Makson G B
authors.initials: MG
authors.lastname: Oliveira
authors.forename: Mairim R
authors.initials: MR
authors.lastname: Serafini
authors.forename: Adriano A S
authors.initials: AA
authors.lastname: Araújo
authors.forename: Angelo R
authors.initials: AR
authors.lastname: Antoniolli
authors.forename: Sócrates C H
authors.initials: SC
authors.lastname: Cavalcanti
authors.forename: Márcio R V
authors.initials: MR
authors.lastname: Santos
authors.forename: Lucindo J
authors.initials: LJ
authors.lastname: Quintans-Júnior
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D000081007:Cymenes; D008297:Male; D051379:Mice; D039821:Monoterpenes / Q000494:pharmacology*
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D000081007:Cymenes; D039821:Monoterpenes; C007210:4-cymene