title: Application of CAD/CAM-assisted technique with surgical treatment in reconstruction of the mandible.
abstract: OBJECTIVE
  The purpose of this clinical study was to explore the optimal method of reconstruct mandible defects individually and immediately.
  
  
  METHODS
  Three-dimensional model simulation technique and vascularized fibular osteomyocutaneous flap were used to repair 15 cases of mandible defects, which were caused by ameloblastoma. A three-dimensional computed tomography (CT) images were converted to a virtual model using CAD software and the 3-dimensional (3D) simulated resin models of skeleton and ﬁbula were used to design the osteotomies, bone segment replacement and titanium mesh shaping preoperatively.
  
  
  RESULTS
  Fibula ﬂaps were alive and no complication occurred. The patients were satisﬁed with the results both esthetically and functionally.
  
  
  CONCLUSIONS
  This preliminarily clinical study and case demonstrated that CAD/CAM-assisted technique with surgical treatment offers an individual anatomical reconstruction of the mandible in ameloblastoma patients. The procedures guarantee intraoperatively an exact placement of the preformed mesh even for precise reconstruction of extensive mandible defects.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Guanghua School of Stomatology, and Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, China.
authors.forename: Jin-Song
authors.initials: JS
authors.lastname: Hou
authors.forename: Mu
authors.initials: M
authors.lastname: Chen
authors.forename: Chao-Bin
authors.initials: CB
authors.lastname: Pan
authors.forename: Miao
authors.initials: M
authors.lastname: Wang
authors.forename: Jian-Guang
authors.initials: JG
authors.lastname: Wang
authors.forename: Bin
authors.initials: B
authors.lastname: Zhang
authors.forename: Qian
authors.initials: Q
authors.lastname: Tao
authors.forename: Cheng
authors.initials: C
authors.lastname: Wang
authors.forename: Hong-Zhang
authors.initials: HZ
authors.lastname: Huang
mesh_terms: D000328:Adult; D000564:Ameloblastoma / Q000601:surgery; D016025:Bone Transplantation / Q000379:methods; D003198:Computer Simulation; D017076:Computer-Aided Design; D004954:Esthetics; D005260:Female; D005360:Fibula / Q000601:surgery; D006085:Graft Survival; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D008297:Male; D008334:Mandible / Q000601:surgery; D008339:Mandibular Neoplasms / Q000601:surgery; D063175:Mandibular Reconstruction / Q000379:methods*; D008875:Middle Aged; D008953:Models, Anatomic; D018482:Muscle, Skeletal / Q000637:transplantation; D010027:Osteotomy / Q000379:methods; D010347:Patient Care Planning; D017060:Patient Satisfaction; D019651:Plastic Surgery Procedures / Q000379:methods*; D016038:Skin Transplantation / Q000379:methods; D013524:Surgical Flaps / Q000637:transplantation; D013526:Surgical Mesh; D014057:Tomography, X-Ray Computed / Q000379:methods; D014584:User-Computer Interface; D055815:Young Adult