title: [Use of cytoflavin into the complex intensive therapy of acute cerebral insufficiency caused by poisoning].
abstract: In the result of treatment of 147 patients with toxic acute brain insufficiency were revealed that the employment of citoflavin (20 ml with 400 ml 5% glucosae twice a day) in 7 days intensive therapy of acute brain insufficiency leaded to decrease of hypoxic brain damages and intensity of brain depression, what was revealed in improvement of brain bioelectric activity. Rehabilitation of central nervous system regulation function and life-support systems leaded to quick rehabilitation of respiratory part of oxygen transport. These changes in acute period leaded to quick reparation of cognitive-mnestic functions and social adaptation. The employment of citoflavin leaded to improvement of clinic of toxicohypoxic encephalopathy and to decrease of secondary lung complications (decrease of coma-period from 45,3 ± 8,2 to 27,7 ± 6,9 hours; decrease of secondary lung complications from 72,7% to 35,9%).
authors.affiliation: Djanelidze Research Institute of Emergency medicine, Saint-Petersburg, Russia.
authors.forename: S
authors.initials: S
authors.lastname: Vasilyev
authors.forename: V
authors.initials: V
authors.lastname: Shilov
authors.forename: M
authors.initials: M
authors.lastname: Aleksandrov
authors.forename: B
authors.initials: B
authors.lastname: Batotsyrenov
authors.forename: A
authors.initials: A
authors.lastname: Loladze
mesh_terms: D002490:Central Nervous System / Q000503:physiopathology*; D003128:Coma; D004338:Drug Combinations; D004569:Electroencephalography; D005260:Female; D005486:Flavin Mononucleotide / Q000008:administration & dosage*; D005947:Glucose / Q000008:administration & dosage; D006801:Humans; D002534:Hypoxia, Brain / Q000188:drug therapy* / Q000473:pathology; D007290:Inosine Diphosphate / Q000008:administration & dosage*; D008297:Male; D018696:Neuroprotective Agents / Q000008:administration & dosage*; D020258:Neurotoxicity Syndromes / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D009498:Neurotoxins / Q000506:poisoning*; D009536:Niacinamide / Q000008:administration & dosage*; D013386:Succinates / Q000008:administration & dosage*
chemical_list: D004338:Drug Combinations; D018696:Neuroprotective Agents; D009498:Neurotoxins; D013386:Succinates; C507879:cytoflavin; D009536:Niacinamide; D005486:Flavin Mononucleotide; D007290:Inosine Diphosphate; D005947:Glucose