title: Detection of new epitopes of antibodies to filaggrin in filaggrin protein molecule.
abstract: Immunogenic characteristics of filaggrin protein molecule as an antigen for antibodies to filaggrin, markers of early rheumatoid arthritis, were studied. Two new peptide motives, possible epitopes for antibodies to filaggrin, were shown in the filaggrin molecule by predictive analysis using programmed algorithms. Only IMG-3 and its cyclic form IMG-4 exhibited antigenic reactivity with sera from rheumatoid arthritis patients, differing significantly from the reactivity with donor sera. The immunogenic characteristics of IMG-3 differed from the characteristics of a previously described epitope.
authors.affiliation: Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, Russia. testres@mail.ru
authors.forename: A G
authors.initials: AG
authors.lastname: Kobylyansky
authors.forename: A N
authors.initials: AN
authors.lastname: Nekrasov
authors.forename: V I
authors.initials: VI
authors.lastname: Kozlova
authors.forename: M Yu
authors.initials: MY
authors.lastname: Sandin
authors.forename: B A
authors.initials: BA
authors.lastname: Alikhanov
authors.forename: V V
authors.initials: VV
authors.lastname: Demkin
mesh_terms: D020816:Amino Acid Motifs / Q000276:immunology; D000595:Amino Acid Sequence; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000276:immunology*; D016022:Case-Control Studies; D018604:Epitope Mapping; D000939:Epitopes / Q000737:chemistry / Q000276:immunology*; D005337:Fibrin / Q000737:chemistry; D000091344:Filaggrin Proteins; D006801:Humans; D007381:Intermediate Filament Proteins / Q000737:chemistry / Q000276:immunology*; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000737:chemistry / Q000276:immunology*; D011485:Protein Binding; D020539:Sequence Analysis, Protein; D017386:Sequence Homology, Amino Acid
chemical_list: D000939:Epitopes; C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins; D010446:Peptide Fragments; D005337:Fibrin