title: An efficient synthesis of a potent anti-inflammatory agent, viscolin, and its inducible nitric oxide synthase inhibitory activity.
abstract: A new and efficient synthetic pathway employed the aldol condensation between the acetophenone (3) and vanillin derivative (4) resulted in the precursor chalcone intermediate (14). The target compound viscolin (1) could be afforded through the hydrogenation of the chalcone and followed by deprotection. The present strategy described the development of a more efficient procedure that allowed large-scale production of viscolin for the further research of biological activity both in vitro and in vivo.
authors.affiliation: Department of Biotechnology, National Formosa University, Yunlin, Taiwan, ROC.
authors.forename: Ping-Chung
authors.initials: PC
authors.lastname: Kuo
authors.forename: Yi-Hsien
authors.initials: YH
authors.lastname: Chen
authors.forename: Yann-Lii
authors.initials: YL
authors.lastname: Leu
authors.forename: Chieh-Hung
authors.initials: CH
authors.lastname: Huang
authors.forename: Yu-Ren
authors.initials: YR
authors.lastname: Liao
authors.forename: E-Jian
authors.initials: EJ
authors.lastname: Lee
authors.forename: Mei-Lin
authors.initials: ML
authors.lastname: Yang
authors.forename: Tian-Shung
authors.initials: TS
authors.lastname: Wu
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001713:Biphenyl Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002599:Chalcone / Q000737:chemistry; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D009569:Nitric Oxide / Q000378:metabolism; D052247:Nitric Oxide Synthase Type II / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011407:Propane / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000893:Anti-Inflammatory Agents; D001713:Biphenyl Compounds; C513809:viscolin; D009569:Nitric Oxide; D002599:Chalcone; D052247:Nitric Oxide Synthase Type II; D011407:Propane