title: Acute stroke phase voluntary cough and correlation with maximum phonation time.
abstract: OBJECTIVE
  This study aimed to assess cough effectiveness after a stroke and to propose a bedside screening test.
  
  
  METHODS
  Patients who had had ischemic hemispheric stroke were recruited and followed up for 2 mos. Maximum phonation time (MPT) was assessed during the first 10 days. Aspiration was evaluated on days 2 and 10 after stroke. Lung function testing was performed on day 10. Peak cough flow less than 160 liters/min was defined as the criterion for cough ineffectiveness. Correlation between peak cough flow and MPT was determined, and the optimal cutoff value relating MPT to effective cough was determined using receiver operating characteristic analysis when referring to peak cough flow.
  
  
  RESULTS
  Of the 70 patients, 6 developed pneumonia (mean time, 1.7 ± 2.4 days). Lung function assessment in 32 cases revealed general reduced cough effectiveness. MPT was correlated with peak cough flow (r = 0.413, P = 0.025), and an MPT cutoff of 10 secs was identified. Forty-seven patients were able to perform MPT on day 2; 49 were able to perform on day 10. Patients with MPT of 10 secs or longer had less frequent aspiration on both day 2 (5.9% vs. 36.7%, P = 0.034) and day 10 (2.9% vs. 26.6%, P = 0.026).
  
  
  CONCLUSIONS
  Cough effectiveness was reduced at the time of greatest risk for pneumonia. MPT provides a reliable bedside screening test of cough effectiveness.
authors.affiliation: Institute of Neuroepidemiology and Tropical Neurology, University of Limoges, Limoges, France.
authors.forename: Zhou
authors.initials: Z
authors.lastname: Zhou
authors.forename: François
authors.initials: F
authors.lastname: Vincent
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Salle
authors.forename: Marie-Thérèse
authors.initials: MT
authors.lastname: Antonini
authors.forename: Vincent
authors.initials: V
authors.lastname: Aliamus
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Daviet
mesh_terms: D000208:Acute Disease; D000368:Aged; D015331:Cohort Studies; D003371:Cough / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010699:Phonation / Q000502:physiology*; D011015:Pneumonia, Aspiration / Q000453:epidemiology* / Q000209:etiology* / Q000503:physiopathology; D019095:Point-of-Care Systems; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D012129:Respiratory Function Tests; D018570:Risk Assessment; D012720:Severity of Illness Index; D020521:Stroke / Q000150:complications* / Q000175:diagnosis* / Q000628:therapy; D015996:Survival Rate; D013997:Time Factors