title: Associations of prenatal exposure to organophosphate pesticide metabolites with gestational age and birth weight.
abstract: BACKGROUND
  Prenatal exposure to organophosphate (OP) insecticides, a widely used class of pesticides, may be associated with decreased gestational age and lower birth weight. Single nucleotide polymorphisms in paroxanase (PON1) enzyme genotypes may modify the relationships between OP exposure and perinatal outcomes.
  
  
  OBJECTIVE
  We examined the relationship of prenatal OP insecticide exposure, measured using urinary dialkyl phosphate (DAP) metabolite concentrations, with gestational age and birth weight.
  
  
  METHODS
  We measured the concentrations of six nonspecific DAP metabolites of OP insecticides in two maternal spot urine samples collected in a prospective birth cohort. We performed multivariable regression to examine associations between the sum of six DAP concentrations (ΣDAP) with gestational age and birth weight. We also examined whether these associations differed according to infant PON1(192) and PON1(-108) genotypes.
  
  
  RESULTS
  Among 306 mother-infant dyads, a 10-fold increase in ΣDAP concentrations was associated with a decrease in covariate-adjusted gestational age [-0.5 weeks; 95% confidence interval (CI): -0.8, -0.1] and birth weight (-151 g; CI: -287, -16); the decrements in birth weight were attenuated after adjusting for gestational age. The relationship between ΣDAP concentrations and gestational age was stronger for white (-0.7 weeks; CI: -1.1, -0.3) than for black (-0.1 weeks; 95% CI: -0.9, 0.6) newborns. In contrast, there was a greater decrease in birth weight with increasing urinary ΣDAP concentrations for black (-188 g; CI: -395, 19) than for white (-118 g; CI: -296, 60) newborns. Decrements in birth weight and gestational age associated with ΣDAP concentrations were greatest among infants with PON1(192QR) and PON(-108CT) genotypes.
  
  
  CONCLUSIONS
  Prenatal urinary ΣDAP concentrations were associated with shortened gestation and reduced birth weight in this cohort, but the effects differed by race/ethnicity and PON1(192/108) genotypes.
authors.affiliation: Child & Family Research Institute, BC Children's Hospital, Vancouver, British Columbia, Canada.
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Rauch
authors.forename: Joe M
authors.initials: JM
authors.lastname: Braun
authors.forename: Dana Boyd
authors.initials: DB
authors.lastname: Barr
authors.forename: Antonia M
authors.initials: AM
authors.lastname: Calafat
authors.forename: Jane
authors.initials: J
authors.lastname: Khoury
authors.forename: Angela M
authors.initials: AM
authors.lastname: Montesano
authors.forename: Kimberly
authors.initials: K
authors.lastname: Yolton
authors.forename: Bruce P
authors.initials: BP
authors.lastname: Lanphear
mesh_terms: D000328:Adult; D001724:Birth Weight / Q000187:drug effects*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D018811:Maternal Exposure / Q000009:adverse effects*; D009943:Organophosphorus Compounds / Q000633:toxicity*; D010575:Pesticides / Q000633:toxicity*; D011247:Pregnancy
chemical_list: D009943:Organophosphorus Compounds; D010575:Pesticides