title: Effects of endosulfan intoxication on pituitary functions.
abstract: BACKGROUND
  We investigated the effects of endosulfan intoxication on pituitary functions in three patients.
  
  
  METHODS
  This is an observational case series including three patients with endosulfan intoxication. Patients were evaluated 3 months after the acute event.
  
  
  RESULTS
  Based on the baseline hormonal values and dynamic endocrine tests, one patient had hypothalamo-pituitary-adrenal axis impairment and was diagnosed as ACTH deficiency (peak cortisol level was found 13.12 μg/dl after low dose ACTH stimulation test), and another one had GH-IGF-I axis impairment and was diagnosed as GH deficiency (peak GH level was found 1.06 μg/L after glucagon stimulation test).
  
  
  CONCLUSIONS
  Endosulfan intoxication might cause pituitary hormone deficiencies after the acute phase. Therefore, patients with endosulfan toxicity should be followed for possible pituitary gland dysfunction.
authors.affiliation: Erciyes University Medical Faculty, Internal Medicine Intensive Care Unit, Kayseri, Turkey. ramcos@erciyes.edu.tr
authors.forename: Ramazan
authors.initials: R
authors.lastname: Coskun
authors.forename: Kursat
authors.initials: K
authors.lastname: Gundogan
authors.forename: Fatih
authors.initials: F
authors.lastname: Tanriverdi
authors.forename: Muhammet
authors.initials: M
authors.lastname: Guven
authors.forename: Murat
authors.initials: M
authors.lastname: Sungur
mesh_terms: D000309:Adrenal Insufficiency / Q000139:chemically induced; D000328:Adult; D004726:Endosulfan / Q000506:poisoning*; D005260:Female; D013006:Growth Hormone / Q000172:deficiency / Q000187:drug effects; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects* / Q000473:pathology; D007306:Insecticides / Q000506:poisoning; D007334:Insulin-Like Growth Factor I / Q000187:drug effects; D010901:Pituitary Function Tests; D010902:Pituitary Gland / Q000187:drug effects* / Q000473:pathology; D010913:Pituitary-Adrenal System / Q000187:drug effects* / Q000473:pathology
chemical_list: D007306:Insecticides; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone; D004726:Endosulfan