title: Synthesis, spectroscopic characterization, DNA interaction and antibacterial study of metal complexes of tetraazamacrocyclic Schiff base.
abstract: The template condensation reaction between benzil and 3,4-diaminotoulene resulted mononuclear 12-membered tetraimine macrocyclic complexes of the type, [MLCl(2)] [M=Co(II), Ni(II), Cu(II) and Zn(II)]. The synthesized complexes have been characterized on the basis of the results of elemental analysis, molar conductance, magnetic susceptibility measurements and spectroscopic studies viz. FT-IR, (1)H and (13)C NMR, FAB mass, UV-vis and EPR. An octahedral geometry has been envisaged for all these complexes, while a distorted octahedral geometry has been noticed for Cu(II) complex. Low conductivity data of all these complexes suggest their non-ionic nature. The interactive studies of these complexes with calf thymus DNA showed that the complexes are avid binders of calf thymus DNA. The in vitro antibacterial studies of these complexes screened against pathogenic bacteria proved them as growth inhibiting agents.
authors.affiliation: Department of Chemistry, Aligarh Muslim University, Aligarh 202002, India. shakir078@yahoo.com
authors.forename: Mohammad
authors.initials: M
authors.lastname: Shakir
authors.forename: Sadiqa
authors.initials: S
authors.lastname: Khanam
authors.forename: Farha
authors.initials: F
authors.lastname: Firdaus
authors.forename: Abdul
authors.initials: A
authors.lastname: Latif
authors.forename: Mohammad
authors.initials: M
authors.lastname: Aatif
authors.forename: Saud I
authors.initials: SI
authors.lastname: Al-Resayes
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D002417:Cattle; D056831:Coordination Complexes / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D004247:DNA / Q000378:metabolism*; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy; D006801:Humans; D047028:Macrocyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D012545:Schiff Bases / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013057:Spectrum Analysis
chemical_list: D000900:Anti-Bacterial Agents; D056831:Coordination Complexes; D047028:Macrocyclic Compounds; D012545:Schiff Bases; D004247:DNA; C427203:calf thymus DNA