title: [Colchicine: what's up, doc?].
abstract: Over de past years use off-label of colchicine has notably increased, mainly as a result of the latest studies published about its efficacy in the prevention of recurrence after acute or recurrent pericarditis and pericarditis after cardiac surgery. Nevertheless, colchicine use has been associated with serious drug interactions and toxicity with high morbimortality. Taking into account the recent results about the efficacy of colchicine in pericarditis management, we envisage an increase in the use of this drug by clinicians. In this review we analyse the risks and current recommendations for a safety use of this ancient drug.
authors.affiliation: Servicio de Farmacia, Hospital Universitario La Paz, Madrid, España. evillabueno@telefonica.net
authors.forename: Elena
authors.initials: E
authors.lastname: Villamañán
authors.forename: Yolanda
authors.initials: Y
authors.lastname: Larrubia
authors.forename: Margarita
authors.initials: M
authors.lastname: Ruano
mesh_terms: D003078:Colchicine / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004347:Drug Interactions; D006801:Humans; D056687:Off-Label Use; D010493:Pericarditis / Q000188:drug therapy*; D050257:Tubulin Modulators / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*
chemical_list: D050257:Tubulin Modulators; D003078:Colchicine