title: Dietary intake and oxidative stress in breast cancer: before and after treatments.
abstract: OBJECTIVE
  The aim of this study was to investigate changes in dietary intake, anthropometric parameters and markers of oxidative stress in 40 women who underwent surgery, chemotherapy or radiation therapy for breast cancer.
  
  
  METHODS
  Pretreatment and post-treatment measurements included data collected through a food frequency questionnaire, weight and height to calculate the body mass index (BMI) and oxidative stress markers assessed from blood reduced glutathione (GSH), serum antioxidant capacity (AC), plasma thiobarbituric acid reactive substances (TBARS), serum lipid hydroperoxides (LH) and plasma carbonyls. Differences were compared using paired Student's t-test or paired Wilcoxon's test.
  
  
  RESULTS
  A significant increase (P < 0.05) in the intake of the food groups: meat and eggs, dairy products, beans, oils and fats, as well as food from the subgroups: red meat, milk and other dairy products rich in fat, fruit rich in vitamin C and vegetable fats was found after treatments. There was a significant increase in body weight (P < 0.05), BMI (P < 0.05), levels of TBARS (P < 0.0001), LH (P < 0.005) and carbonyls (P < 0.0001) and a significant decrease of levels of AC (P < 0.005) and GSH (P < 0.0001).
  
  
  CONCLUSIONS
  Breast cancer diagnosis and treatments were associated with dietary intake changes and increased body weight, BMI and oxidative stress. These potential changes have important implications for preventive nutrition counseling.
authors.affiliation: Nutrition Pos-Graduate Program, Federal University of Santa Catarina, Santa Catarina, Brazil.
authors.forename: G
authors.initials: G
authors.lastname: Rockenbach
authors.forename: P F
authors.initials: PF
authors.lastname: Di Pietro
authors.forename: C
authors.initials: C
authors.lastname: Ambrosi
authors.forename: B C B
authors.initials: BC
authors.lastname: Boaventura
authors.forename: F G K
authors.initials: FG
authors.lastname: Vieira
authors.forename: C G
authors.initials: CG
authors.lastname: Crippa
authors.forename: E L
authors.initials: EL
authors.lastname: Da Silva
authors.forename: M A
authors.initials: MA
authors.lastname: Fausto
mesh_terms: D000328:Adult; D000368:Aged; D000886:Anthropometry; D015415:Biomarkers; D015992:Body Mass Index; D001835:Body Weight / Q000502:physiology; D001938:Brazil; D001943:Breast Neoplasms / Q000378:metabolism* / Q000628:therapy; D003131:Combined Modality Therapy; D004032:Diet; D004435:Eating; D005247:Feeding Behavior; D005260:Female; D005978:Glutathione / Q000097:blood; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D050050:Protein Carbonylation; D011795:Surveys and Questionnaires; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D015415:Biomarkers; D008054:Lipid Peroxides; D017392:Thiobarbituric Acid Reactive Substances; D005978:Glutathione