title: 2,2'-Dithienyl diselenide, an organoselenium compound, elicits antioxidant action and inhibits monoamine oxidase activity in vitro.
abstract: BACKGROUND
  Organoselenium compounds have been described as antioxidant and neuroprotective agents.
  
  
  OBJECTIVE
  To evaluate the antioxidant action of 2,2'-dithienyl diselenide (DTDS) and its effects in brain monoamine oxidase (MAO) activity in vitro.
  
  
  METHODS
  Assays for reactive species (RS), lipid peroxidation, protein oxidation, MAO A and B activities in rat brain homogenate as well as mimetic dehydroascorbate reductase and glutathione S-transferase activities were performed using DTDS (μM range).
  
  
  RESULTS
  DTDS was effective in decreasing the levels of RS as well as lipid peroxidation induced by malonate, sodium nitroprusside or FeCl₂/EDTA and protein carbonyl in the rat brain homogenate. DTDS elicited dehydroascorbate reductase-like and glutathione S-transferase-like activities. DTDS was effective in inhibiting both MAO-A and MAO-B activities.
  
  
  CONCLUSIONS
  The results demonstrated that DTDS is an antioxidant agent with non-selective inhibitory effect on MAO activity.
  
  
  CONCLUSIONS
  DTDS is a promising molecule to be evaluated in experimental models of neurological diseases.
authors.affiliation: Laboratório de Síntese, Reatividade e Avaliação Farmacológica e Toxicológica de Organocalcogênios, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, Santa Maria, CEP, RS, Brasil.
authors.forename: Cristiani F
authors.initials: CF
authors.lastname: Bortolatto
authors.forename: Pietro M
authors.initials: PM
authors.lastname: Chagas
authors.forename: Ethel A
authors.initials: EA
authors.lastname: Wilhelm
authors.forename: Gilson
authors.initials: G
authors.lastname: Zeni
authors.forename: Cristina W
authors.initials: CW
authors.lastname: Nogueira
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001921:Brain / Q000201:enzymology*; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation / Q000187:drug effects; D008297:Male; D015394:Molecular Structure; D008995:Monoamine Oxidase / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D016566:Organoselenium Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: C583912:2,2'-dithienyl diselenide; D000975:Antioxidants; D008996:Monoamine Oxidase Inhibitors; D016566:Organoselenium Compounds; D013876:Thiophenes; D008995:Monoamine Oxidase