title: Long-term outcome of infrapopliteal catheter-based intervention for critical limb ischemia.
abstract: BACKGROUND
  Percutaneous treatment of tibioperoneal occlusive disease is associated with decreased morbidity compared with bypass surgery. The long-term patency and limb salvage rates are not well documented.
  
  
  OBJECTIVE
  To evaluate the long-term outcome of endoluminal interventions for tibioperoneal lesions.
  
  
  METHODS
  A retrospective study was performed to determine the outcomes of patients undergoing infrapopliteal catheter-based intervention for critical limb ischemia. Collected data included demographics, comorbidities, clinical presentation, pre- and postintervention noninvasive vascular measurements (segmental pressure and waveforms, and ankle-brachial index [ABI]), type of intervention, limb loss rate, patient follow-up and need for surgical revascularization. Statistical analysis was performed with the two-tailed t test. P<0.05 was considered significant; results were reported as mean ± SD. Cox regression analysis and Kaplan-Meier limb survival analysis were performed to demonstrate freedom from amputation over time.
  
  
  RESULTS
  Thirty-five patients underwent intervention from 2003 to 2008; technical success was achieved in 26 patients (75%). Arterial segmental pressure studies revealed a significant increase in ABI - preprocedure ABI was 0.62±0.24 versus a postintervention ABI of 0.81±0.29 (P=0.02). The limb salvage rate was 63% during the follow-up period. Limb salvage was better for patients who underwent isolated infrapopliteal intervention versus combined above and below the knee intervention.
  
  
  CONCLUSIONS
  Percutaneous interventions for tibioperoneal occlusive disease offer an acceptable limb salvage rate and may be the preferred initial treatment for critical limb ischemia.
authors.affiliation: University of Kentucky Medical Center, Division of Vascular Surgery; Veterans Affairs Medical Center, Lexington, Kentucky, USA.
authors.forename: Nick N
authors.initials: NN
authors.lastname: Abedi
authors.forename: Daniel L
authors.initials: DL
authors.lastname: Davenport
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Karagiorgos
authors.forename: David J
authors.initials: DJ
authors.lastname: Minion
authors.forename: Ehab E
authors.initials: EE
authors.lastname: Sorial
authors.forename: Eric D
authors.initials: ED
authors.lastname: Endean
authors.forename: Eleftherios S
authors.initials: ES
authors.lastname: Xenos