title: P2 receptors for extracellular nucleotides in the central nervous system: role of P2X7 and P2Y₂ receptor interactions in neuroinflammation.
abstract: Extracellular nucleotides induce cellular responses in the central nervous system (CNS) through the activation of ionotropic P2X and metabotropic P2Y nucleotide receptors. Activation of these receptors regulates a wide range of physiological and pathological processes. In this review, we present an overview of the current literature regarding P2X and P2Y receptors in the CNS with a focus on the contribution of P2X7 and P2Y(2) receptor-mediated responses to neuroinflammatory and neuroprotective mechanisms.
authors.affiliation: Department of Biochemistry, University of Missouri, 540E Life Sciences Center, 1201 Rollins Road, Columbia, MO 65211-7310, USA. weismang@missouri.edu
authors.forename: Gary A
authors.initials: GA
authors.lastname: Weisman
authors.forename: Jean M
authors.initials: JM
authors.lastname: Camden
authors.forename: Troy S
authors.initials: TS
authors.lastname: Peterson
authors.forename: Deepa
authors.initials: D
authors.lastname: Ajit
authors.forename: Lucas T
authors.initials: LT
authors.lastname: Woods
authors.forename: Laurie
authors.initials: L
authors.lastname: Erb
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D007249:Inflammation / Q000473:pathology*; D018696:Neuroprotective Agents / Q000378:metabolism; D009711:Nucleotides / Q000378:metabolism*; D058486:Receptors, Purinergic P2X7 / Q000378:metabolism*; D058473:Receptors, Purinergic P2Y2 / Q000378:metabolism*
chemical_list: D018696:Neuroprotective Agents; D009711:Nucleotides; D058486:Receptors, Purinergic P2X7; D058473:Receptors, Purinergic P2Y2