title: A novel antibacterial resin composite for improved dental restoratives.
abstract: A novel furanone-containing antibacterial resin composite has been prepared and evaluated. compressive strength (CS) and Streptococcus mutans viability were used to evaluate the mechanical strength and antibacterial activity of the composites. The modified resin composites showed a significant antibacterial activity without substantially decreasing the mechanical strengths. With 5-30 % addition of the furanone derivative, the composite kept its original CS unchanged but showed a significant antibacterial activity with a 16-68 % reduction in the S. mutans viability. Further, the antibacterial function of the new composite was not affected by human saliva. The aging study indicates that the composite may have a long-lasting antibacterial function. Within the limitations of this study, it appears that the experimental antibacterial resin composite may potentially be developed into a clinically attractive dental restorative due to its high mechanical strength and antibacterial function.
authors.affiliation: Department of Biomedical Engineering, Purdue School of Engineering and Technology, Indiana University-Purdue University at Indianapolis, Indianapolis, IN 46202, USA.
authors.forename: Yiming
authors.initials: Y
authors.lastname: Weng
authors.forename: Leah
authors.initials: L
authors.lastname: Howard
authors.forename: Xia
authors.initials: X
authors.lastname: Guo
authors.forename: Voon Joe
authors.initials: VJ
authors.lastname: Chong
authors.forename: Richard L
authors.initials: RL
authors.lastname: Gregory
authors.forename: Dong
authors.initials: D
authors.lastname: Xie
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use*; D003188:Composite Resins / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use*; D019245:Compressive Strength; D003793:Dental Restoration, Permanent / Q000379:methods*; D006801:Humans; D066298:In Vitro Techniques; D008422:Materials Testing; D008826:Microbial Sensitivity Tests; D012463:Saliva / Q000502:physiology; D017550:Spectroscopy, Fourier Transform Infrared; D013295:Streptococcus mutans / Q000187:drug effects; D013718:Tensile Strength
chemical_list: D000900:Anti-Bacterial Agents; D003188:Composite Resins