title: End-stage liver disease: prevalence, risk factors and clinical characteristics in a cohort of HIV-HCV coinfected Han Chinese.
abstract: BACKGROUND
  Since the advent of combined antiretroviral therapy (cART), liver-related mortality has become the leading cause of non-AIDS-related deaths in human immunodeficiency virus (HIV) infected patients in Western countries.
  
  
  OBJECTIVE
  To investigate the incidence, mortality and risk factors of end-stage liver disease (ESLD) in HIV and hepatitis C virus (HCV) coinfected former plasma donors (FPDs) and blood recipients (BRs).
  
  
  METHODS
  A retrospective study was conducted.
  
  
  RESULTS
  Of 321 HIV-HCV coinfected patients, 42 (13.1%) developed ESLD and 40 (12.5%) died. Factors that were independently associated with ESLD included older age at baseline (Odds ratios [OR]: 2.444, P=0.035), alanine aminotransferase (ALT) greater or equal to 2 (the upper limit of normal [ULN]) at the end of follow-up (OR: 16.460, P=0.000), hepatitis B virus (HBV) (OR: 2.525, P=0.043), CDC stage C (OR: 5.806, P=0.001), duration of cART greater than 5 years (OR: 3.256, P=0.010), and CD4 count greater or equal to 200 cells/mm(3) at the end of follow-up (OR: 0.383, P=0.016). The probability of developing ESLD in HIV-HCV coinfected BRs was significantly higher than in FPDs (P=0.008). Mortality was also significantly higher in HIV-HCV coinfected patients with ESLD than in those without ESLD (P=0.000).
  
  
  CONCLUSIONS
  In the cART era, ESLD was common among HIV-HCV coinfected Han Chinese patients and was responsible for reducing patient survival time.
authors.affiliation: Department of Infectious Disease, Zhongnan Hospital, Wuhan University, Hubei Province, China.
authors.forename: Liping
authors.initials: L
authors.lastname: Deng
authors.forename: Xien
authors.initials: X
authors.lastname: Gui
authors.forename: Yong
authors.initials: Y
authors.lastname: Xiong
authors.forename: Shicheng
authors.initials: S
authors.lastname: Gao
authors.forename: Rongrong
authors.initials: R
authors.lastname: Yang
authors.forename: Yuping
authors.initials: Y
authors.lastname: Rong
authors.forename: Jinzhi
authors.initials: J
authors.lastname: Hu
authors.forename: Yajun
authors.initials: Y
authors.lastname: Yan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D044466:Asian People; D060085:Coinfection; D058625:End Stage Liver Disease / Q000150:complications* / Q000453:epidemiology*; D005260:Female; D015658:HIV Infections / Q000150:complications*; D019698:Hepatitis C, Chronic / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D055815:Young Adult