title: Early diagnosis and treatment for remission of clinically amyopathic dermatomyositis complicated by rapid progress interstitial lung disease: a report of two cases.
abstract: We report two cases of clinically amyopathic dermatomyositis (CADM) complicated by rapid progress interstitial lung disease (RPILD). The diagnosis of CADM was based on Gottron's papule and RPILD, and the absence of muscle weakness. The female patients were treated with early immunosuppressive therapies including steroid pulse therapy, resulting in significant improvement in respiratory symptoms, clinical data, and imaging. Measurement of anti-CADM-140/MDA5 antibody was useful for obtaining a definitive diagnosis of CADM in these cases.
authors.affiliation: Unit of Translational Medicine, Department of Rheumatology, Graduate School of Biomedical Sciences, Nagasaki University, 1-7-1 Sakamoto, Nagasaki, 852-8501, Japan. yoshirohorai0518@yahoo.co.jp
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Horai
authors.forename: Eriko
authors.initials: E
authors.lastname: Isomoto
authors.forename: Tomohiro
authors.initials: T
authors.lastname: Koga
authors.forename: Akitomo
authors.initials: A
authors.lastname: Okada
authors.forename: Shin-Ya
authors.initials: SY
authors.lastname: Kawashiri
authors.forename: Mami
authors.initials: M
authors.lastname: Tamai
authors.forename: Satoshi
authors.initials: S
authors.lastname: Yamasaki
authors.forename: Hideki
authors.initials: H
authors.lastname: Nakamura
authors.forename: Tomoki
authors.initials: T
authors.lastname: Origuchi
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Hamaguchi
authors.forename: Manabu
authors.initials: M
authors.lastname: Fujimoto
authors.forename: Masataka
authors.initials: M
authors.lastname: Kuwana
authors.forename: Atsushi
authors.initials: A
authors.lastname: Kawakami
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood; D003882:Dermatomyositis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D042241:Early Diagnosis; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D036341:Intercellular Signaling Peptides and Proteins; D017563:Lung Diseases, Interstitial / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D008875:Middle Aged; D018908:Muscle Weakness; D010455:Peptides / Q000276:immunology; D011379:Prognosis; D020551:Pulse Therapy, Drug; D013902:Radiography, Thoracic; D020127:Recovery of Function; D012074:Remission Induction; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome
chemical_list: D001323:Autoantibodies; C501597:CADM-140 peptide, human; D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides