title: Hepatoprotective effects of dieckol-rich phlorotannins from Ecklonia cava, a brown seaweed, against ethanol induced liver damage in BALB/c mice.
abstract: Alcoholic liver disease, which is one of the most serious liver disorders, has been known to cause by ethanol intake. In the present study, in vivo hepatoprotective effects of dieckol-rich phlorotannins (DRP) from Ecklonia cava, a brown seaweed, on ethanol induced hepatic damage in BALB/c mice liver were investigated. After administration of 5 and 25mg/kg mouse of DRP and 4 g/kg mice ethanol, the body weights and survival rates were increased as compared to the control, which is ethanol-treated group without DRP. The glutamic oxaloacetic transaminase and glutamic pyruvic transaminase levels in the serum were lower than those of the control. DRP exhibited a reduction of the total cholesterol. The lower levels of SOD enzyme and a reduction of the formation of malondialdehyde were occurred in mice fed with 5 and 25mg/kg mouse of DRP. Finally the effect on improvement of fatty liver induced by ethanol was observed by taking out the liver immediately after dissecting the mouse. However, no significant difference was observed on hepatic histopathological changes. In conclusion, this study indicated that DRP could protect liver injury induced by ethanol in vivo. It suggested that DRP possesses the beneficial effect to human against ethanol-induced liver injury.
authors.affiliation: Department of Marine Life Sciences, Jeju National University, Jeju 690-756, Republic of Korea.
authors.forename: Min-Cheol
authors.initials: MC
authors.lastname: Kang
authors.forename: Ginnae
authors.initials: G
authors.lastname: Ahn
authors.forename: Xiudong
authors.initials: X
authors.lastname: Yang
authors.forename: Kil-Nam
authors.initials: KN
authors.lastname: Kim
authors.forename: Sung-Myung
authors.initials: SM
authors.lastname: Kang
authors.forename: Seung-Hong
authors.initials: SH
authors.lastname: Lee
authors.forename: Seok-Chun
authors.initials: SC
authors.lastname: Ko
authors.forename: Ju-Young
authors.initials: JY
authors.lastname: Ko
authors.forename: Daekyung
authors.initials: D
authors.lastname: Kim
authors.forename: Yong-Tae
authors.initials: YT
authors.lastname: Kim
authors.forename: Youngheun
authors.initials: Y
authors.lastname: Jee
authors.forename: Sun-Joo
authors.initials: SJ
authors.lastname: Park
authors.forename: You-Jin
authors.initials: YJ
authors.lastname: Jeon
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001572:Benzofurans / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D005979:Glutathione Peroxidase / Q000378:metabolism; D006519:Hepatitis, Alcoholic / Q000473:pathology / Q000517:prevention & control*; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000473:pathology; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D051379:Mice; D008807:Mice, Inbred BALB C; D056910:Republic of Korea; D012624:Seaweed / Q000737:chemistry*; D013534:Survival; D013634:Tannins / Q000494:pharmacology*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D001572:Benzofurans; D013634:Tannins; D017392:Thiobarbituric Acid Reactive Substances; C503840:dieckol; D008315:Malondialdehyde; D002784:Cholesterol; D005979:Glutathione Peroxidase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase