title: Usefulness of OCT4/3 immunostain in pediatric malignant germ cell tumors.
abstract: Octamer4/3 is a POU transcription factor that regulates pluripotentiality in embryonic stem and germ cells and primordial germ cells. When expressed in post-embryonic life, Octamer4/3 may lead to malignant germ cell tumors (GCT). Thirty samples were selected for this study (26 GCT samples and 4 cryptorchid testes samples) and 16 non-GCT were used as controls. Samples were stained with an anti-Octamer4/3 antibody. All cases of GCT were positive for Octamer4/3, and the non-GCT were negative. This article focuses on pediatric populations where we found that Octamer4/3 immunostaining is a useful diagnostic tool in undifferentiated pediatric tumors.
authors.affiliation: Children's Healthcare of Atlanta, Department of Pathology, Atlanta, GA 30322, USA.
authors.forename: Sarah
authors.initials: S
authors.lastname: Talebagha
authors.forename: Christine
authors.initials: C
authors.lastname: Rizk
authors.forename: Nancy
authors.initials: N
authors.lastname: Elawabdeh
authors.forename: Carlos R
authors.initials: CR
authors.lastname: Abramowsky
authors.forename: Bahig M
authors.initials: BM
authors.lastname: Shehata
mesh_terms: D000293:Adolescent; D014408:Biomarkers, Tumor / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D007231:Infant, Newborn; D009373:Neoplasms, Germ Cell and Embryonal / Q000175:diagnosis* / Q000378:metabolism; D050814:Octamer Transcription Factor-3 / Q000032:analysis* / Q000096:biosynthesis
chemical_list: D014408:Biomarkers, Tumor; D050814:Octamer Transcription Factor-3; C494173:POU5F1 protein, human