title: Emerging insights into the molecular and cellular basis of glioblastoma.
abstract: Glioblastoma is both the most common and lethal primary malignant brain tumor. Extensive multiplatform genomic characterization has provided a higher-resolution picture of the molecular alterations underlying this disease. These studies provide the emerging view that "glioblastoma" represents several histologically similar yet molecularly heterogeneous diseases, which influences taxonomic classification systems, prognosis, and therapeutic decisions.
authors.affiliation: Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
authors.forename: Gavin P
authors.initials: GP
authors.lastname: Dunn
authors.forename: Mikael L
authors.initials: ML
authors.lastname: Rinne
authors.forename: Jill
authors.initials: J
authors.lastname: Wykosky
authors.forename: Giannicola
authors.initials: G
authors.lastname: Genovese
authors.forename: Steven N
authors.initials: SN
authors.lastname: Quayle
authors.forename: Ian F
authors.initials: IF
authors.lastname: Dunn
authors.forename: Pankaj K
authors.initials: PK
authors.lastname: Agarwalla
authors.forename: Milan G
authors.initials: MG
authors.lastname: Chheda
authors.forename: Benito
authors.initials: B
authors.lastname: Campos
authors.forename: Alan
authors.initials: A
authors.lastname: Wang
authors.forename: Cameron
authors.initials: C
authors.lastname: Brennan
authors.forename: Keith L
authors.initials: KL
authors.lastname: Ligon
authors.forename: Frank
authors.initials: F
authors.lastname: Furnari
authors.forename: Webster K
authors.initials: WK
authors.lastname: Cavenee
authors.forename: Ronald A
authors.initials: RA
authors.lastname: Depinho
authors.forename: Lynda
authors.initials: L
authors.lastname: Chin
authors.forename: William C
authors.initials: WC
authors.lastname: Hahn
mesh_terms: D001932:Brain Neoplasms / Q000145:classification* / Q000235:genetics* / Q000473:pathology; D020869:Gene Expression Profiling; D016147:Genes, Tumor Suppressor; D023281:Genomics; D005909:Glioblastoma / Q000145:classification* / Q000235:genetics* / Q000473:pathology; D006801:Humans; D009389:Neovascularization, Pathologic / Q000235:genetics; D014158:Transcription, Genetic