title: Medical management of recurrent endometrioma with long-term norethindrone acetate.
abstract: OBJECTIVE
  Evaluate the efficacy of norethindrone acetate in the resolution of symptoms and regression of recurrent endometrioma.
  
  
  METHODS
  Retrospective chart review at SUNY Downstate Medical Center of patients with a history of surgical excision of endometrioma (with histological confirmation) and recurrent endometrioma (demonstrated by strict sonographic criterion of endometrioma) who were willing to undergo follow-up. Patients were prescribed norethindrone acetate to be taken daily with follow-up sonograms until cysts regressed. Statistical analysis included Student's t-test and a simple linear regression model to assess cyst regression over time during treatment.
  
  
  RESULTS
  Degree of pain was significantly lower on treatment when compared to baseline (P < 0.00001). Cyst size was significantly smaller in as little as 3 months (P < 0.0001). Average rate of regression with continuous treatment was 0.025 ± 0.015 cm/day. Total mean ± standard deviation regression time is 10.28 ± 8.25 months.
  
  
  CONCLUSIONS
  Norethindrone acetate was effective in eradicating symptoms and producing complete regression of recurrent endometriomas. It should be considered for patients who are likely to adhere to a prolonged treatment regimen and comply with recommendations for surveillance with serial sonograms.
authors.affiliation: Department of Obstetrics and Gynecology, SUNY Downstate Medical Center, New York, NY, USA.
authors.forename: Ozgul
authors.initials: O
authors.lastname: Muneyyirci-Delale
authors.forename: Jenny
authors.initials: J
authors.lastname: Anopa
authors.forename: Cassandra
authors.initials: C
authors.lastname: Charles
authors.forename: Deepali
authors.initials: D
authors.lastname: Mathur
authors.forename: Rudolph
authors.initials: R
authors.lastname: Parris
authors.forename: Jed B
authors.initials: JB
authors.lastname: Cutler
authors.forename: Ghadir
authors.initials: G
authors.lastname: Salame
authors.forename: Ovadia
authors.initials: O
authors.lastname: Abulafia