title: Splenic re-irradiation for waldenstrőm's macroglobulinemia.
abstract: We report on a case of Waldenström's macroglobulinemia (WM) treated with splenic re-irradiation. To the best of our knowledge this has not been reported before. A 69-year-old Asian female patient with WM received a three-dimensional conformal radiotherapy, with 24 Gy in 12 treatment fractions in the first stage. She tolerated the treatment well, with a 37% reduction of the monoclonal immunoglobulin, an impalpable spleen, and improved hematological laboratory tests for 4 months. She was then treated with splenic re-irradiation up to 24 Gy for tumor progression. She showed no evidence of progression one year after re-irradiation, with a 55% reduction of the monoclonal immunoglobulin. Our experience demonstrates that splenic irradiation is an effective treatment to control the progression of WM.
authors.affiliation: Department of Radiotherapy, Cancer Centre, Qilu Hospital, Shandong University, 107 Wenhuaxi Street, Jinan, Shandong 250012, China.
authors.forename: Zhou
authors.initials: Z
authors.lastname: Wei
authors.forename: Yu
authors.initials: Y
authors.lastname: Yanxia
authors.forename: Xu
authors.initials: X
authors.lastname: Ying
authors.forename: Wang
authors.initials: W
authors.lastname: Han
authors.forename: Jiang
authors.initials: J
authors.lastname: Yuhua
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002699:Chlorambucil / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000627:therapeutic use; D018450:Disease Progression; D005260:Female; D006801:Humans; D020266:Radiotherapy, Conformal; D013154:Spleen / Q000473:pathology* / Q000528:radiation effects; D013792:Thalidomide / Q000627:therapeutic use; D014740:Vidarabine / Q000031:analogs & derivatives / Q000627:therapeutic use; D008258:Waldenstrom Macroglobulinemia / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy*
chemical_list: D000970:Antineoplastic Agents; D002699:Chlorambucil; D013792:Thalidomide; D003520:Cyclophosphamide; D014740:Vidarabine; C024352:fludarabine