title: Development of nanoaptamers using a mesoporous silica model labeled with (99m)tc for cancer targeting.
abstract: The use of mesoporous silica in targeted cancer therapy is increasing daily. The combination of a rigid model of nanoparticles like mesoporous silica and biological compounds with an affinity for oncological diseases is the most promising drug-targeting system nowadays. In this study, we used the mesoporous silica SBA-15 combined with aptamer (functionalized for tumor with MUC1). The results obtained were of interest and showed the formation of the silica mesoporous structure. The impregnation methodology of mesoporous silica with the aptamer was also confirmed. Cytotoxicity results demonstrated that the particle associated with the aptamer has no cytotoxicity. We conclude that although further studies are required, the mesoporous silica nanoparticle model loaded with aptamer is very functional and can be used for other applications, especially in nuclear medicine.
authors.affiliation: Departamento de Química, Pontificia Universidade Católica do Rio de Janeiro, Rio de Janeiro, Brazil.
authors.forename: Lucas Torres Miranda
authors.initials: LT
authors.lastname: Sá
authors.forename: Claudia
authors.initials: C
authors.lastname: Pessoa
authors.forename: Assuero Silva
authors.initials: AS
authors.lastname: Meira
authors.forename: Maria Isabel Pais
authors.initials: MI
authors.lastname: da Silva
authors.forename: Sotiris
authors.initials: S
authors.lastname: Missailidis
authors.forename: Ralph
authors.initials: R
authors.lastname: Santos-Oliveira
mesh_terms: D052157:Aptamers, Nucleotide / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000037:antagonists & inhibitors* / Q000378:metabolism; D045744:Cell Line, Tumor; D016503:Drug Delivery Systems; D006801:Humans; D008954:Models, Biological; D053758:Nanoparticles; D009369:Neoplasms / Q000188:drug therapy*; D012822:Silicon Dioxide / Q000627:therapeutic use*
chemical_list: D052157:Aptamers, Nucleotide; D014408:Biomarkers, Tumor; C509969:SBA-15; D012822:Silicon Dioxide