title: Enhanced selectivity for the hydrolysis of block copoly(2-oxazoline)s in ethanol-water resulting in linear poly(ethylene imine) copolymers.
abstract: The ability of merging the properties of poly(2-oxazoline)s and poly(ethylene imine) is of high interest for various biomedical applications, including gene delivery, biosensors, and switchable surfaces and nanoparticles. In the present research, a methodology for the controlled and selective hydrolysis of (co)poly(2-oxazoline)s is developed in an ethanol-water solvent mixture, opening the path toward a wide range of block poly(2-oxazoline-co-ethylene imine) (POx-PEI) copolymers with tunable properties. The unexpected influence of the selected ethanol-water binary solvent mixture on the hydrolysis kinetics and selectivity is highlighted in the pursue of well-defined POx-PEI block copolymers.
authors.affiliation: Laboratory of Polymer Chemistry, Eindhoven University of Technology, PO Box 513, Eindhoven, 5600 MB, The Netherlands.
authors.forename: Huub P C
authors.initials: HP
authors.lastname: van Kuringen
authors.forename: Victor R
authors.initials: VR
authors.lastname: de la Rosa
authors.forename: Martin W M
authors.initials: MW
authors.lastname: Fijten
authors.forename: Johan P A
authors.initials: JP
authors.lastname: Heuts
authors.forename: Richard
authors.initials: R
authors.lastname: Hoogenboom
mesh_terms: D000431:Ethanol / Q000737:chemistry; D006868:Hydrolysis; D007097:Imines / Q000138:chemical synthesis* / Q000737:chemistry; D007700:Kinetics; D010080:Oxazoles / Q000737:chemistry*; D011073:Polyamines / Q000737:chemistry*; D011095:Polyethylenes / Q000138:chemical synthesis* / Q000737:chemistry; D011108:Polymers / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: D007097:Imines; D010080:Oxazoles; D011073:Polyamines; D011095:Polyethylenes; D011108:Polymers; D012997:Solvents; C511916:poly(2-ethyl-2-oxazoline); C117403:poly(2-methyl-2-oxazoline); C505405:poly(ethylene imine); D014867:Water; D000431:Ethanol