title: The CD34-microvascular density in colorectal cancer patients.
abstract: OBJECTIVE
  To investigate the influence of the angiogenesis parameter CD34 microvascular density (MVD) on overall survival of colorectal cancer (CRC) patients.
  
  
  METHODS
  Thirty-one CRC patients were followed-up for 72 months after curative colorectal operation. Blood vessels measurement was done using the CD34-MVD immunochemistry method, and light microscopy.
  
  
  RESULTS
  MVD was inversely correlated with patients' survival. MVD value < 35 proved as independent good prognostic factor, and patients with this value lived during the 72-month follow up after surgery, while a MVD value > 65 was an independent poor prognostic factor and such patients died within 11 months after radical surgery for CRC (p<0.01).
  
  
  CONCLUSIONS
  According to these results, the CD34-MVD seems to be a significant prognosticator of overall survival in CRC patients.
authors.affiliation: Department of Surgery, Clinical Hospital Center-Zemun, Belgrade, Serbia.
authors.forename: I
authors.initials: I
authors.lastname: Balac
authors.forename: V
authors.initials: V
authors.lastname: Jurisic
authors.forename: A
authors.initials: A
authors.lastname: Laban
authors.forename: T
authors.initials: T
authors.lastname: Randelovic
authors.forename: P
authors.initials: P
authors.lastname: Knezevic
authors.forename: I
authors.initials: I
authors.lastname: Pantic
authors.forename: R
authors.initials: R
authors.lastname: Dzodic
mesh_terms: D000368:Aged; D018952:Antigens, CD34 / Q000032:analysis*; D015179:Colorectal Neoplasms / Q000098:blood supply* / Q000401:mortality; D005260:Female; D006801:Humans; D008297:Male; D055806:Microvessels / Q000737:chemistry*; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies
chemical_list: D018952:Antigens, CD34