title: A carbosilane dendrimer and a silacyclopentadiene analog carrying peripheral lactoses as drug-delivery systems.
abstract: A carbosilane dendrimer (4a) and its silacyclopentadiene analog (4b), both functionalized with lactoses, were tested for their abilities to act as drug-delivery systems. The critical micelle concentrations of 4a and 4b were measured using the drop-volume method in water and were 1.7 and 2.9 μM, respectively, suggesting that they could act as aggregates of glycoclusters. The amounts of the hydrophobic dye Orange OT loaded onto aqueous micelles of 4a and 4b and the stabilities of the dye/micelle complexes were determined by extracting the dyes from the complexes into chloroform. The particle sizes were measured for the loaded micelles by dynamic light scattering. Transfer of the dye from the micelles to peanut agglutinin was observed by fluorescence microscopy. Given the abilities of micelles of 4a and 4b to bind and release Orange OT, these glycocluster micelles may find use as drug-delivery systems.
authors.affiliation: Division of Material Science, Graduate School of Science and Technology, Saitama University, Sakura-ku, Saitama-shi, Saitama-ken, Japan.
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Aizawa
authors.forename: Kentaro
authors.initials: K
authors.lastname: Otomo
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Honsho
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Shimazaki
authors.forename: Masumi
authors.initials: M
authors.lastname: Villeneuve
authors.forename: Koji
authors.initials: K
authors.lastname: Matsuoka
authors.forename: Ken
authors.initials: K
authors.lastname: Hatano
authors.forename: Daiyo
authors.initials: D
authors.lastname: Terunuma
mesh_terms: D000466:Alkadienes / Q000008:administration & dosage / Q000494:pharmacology*; D016503:Drug Delivery Systems; D008823:Micelles; D008856:Microscopy, Fluorescence
chemical_list: D000466:Alkadienes; D008823:Micelles