title: Body size and risk of differentiated thyroid carcinomas: findings from the EPIC study.
abstract: Results from case-control and prospective studies suggest a moderate positive association between obesity and height and differentiated thyroid carcinoma (TC). Little is known on the relationship between other measures of adiposity and differentiated TC risk. Here, we present the results of a study on body size and risk of differentiated TC based on a large European prospective study (EPIC). During follow-up, 508 incident cases of differentiated TC were identified in women, and 58 in men. 78% of cases were papillary TC. Cox proportional hazard models were used to estimate hazard ratios (HRs). In women, differentiated TC risk was significantly associated with body mass index (BMI, kg/m(2)) (HR highest vs lowest quintile = 1.41, 95% CI: 1.03-1.94); height (HR = 1.61; 95% CI: 1.18-2.20); HR highest vs lowest tertile waist (HR = 1.34, 95% CI: 1.00-1.79) and waist-to-hip ratio (HR = 1.42, 95% CI: 1.05-1.91). The association with BMI was somewhat stronger in women below age 50. Corresponding associations for papillary TC were similar to those for all differentiated TC. In men the only body size factors significantly associated with differentiated TC were height (non linear), and leg length (HR highest vs. lowest tertile = 3.03, 95% CI: 1.30-7.07). Our study lends further support to the presence of a moderate positive association between differentiated TC risk and overweight and obesity in women. The risk increase among taller individuals of both sexes suggests that some genetic characteristics or early environmental exposures may also be implicated in the etiology of differentiated TC.
authors.affiliation: International Agency for Research on Cancer, Lyon, France. Rinaldi@iarc.fr
authors.forename: Sabina
authors.initials: S
authors.lastname: Rinaldi
authors.forename: Mauro
authors.initials: M
authors.lastname: Lise
authors.forename: Françoise
authors.initials: F
authors.lastname: Clavel-Chapelon
authors.forename: Marie-Christine
authors.initials: MC
authors.lastname: Boutron-Ruault
authors.forename: Gwenaelle
authors.initials: G
authors.lastname: Guillas
authors.forename: Kim
authors.initials: K
authors.lastname: Overvad
authors.forename: Anne
authors.initials: A
authors.lastname: Tjønneland
authors.forename: Jytte
authors.initials: J
authors.lastname: Halkjær
authors.forename: Annekatrin
authors.initials: A
authors.lastname: Lukanova
authors.forename: Rudolf
authors.initials: R
authors.lastname: Kaaks
authors.forename: Manuela M
authors.initials: MM
authors.lastname: Bergmann
authors.forename: Heiner
authors.initials: H
authors.lastname: Boeing
authors.forename: Antonia
authors.initials: A
authors.lastname: Trichopoulou
authors.forename: Dimosthenis
authors.initials: D
authors.lastname: Zylis
authors.forename: Elissavet
authors.initials: E
authors.lastname: Valanou
authors.forename: Domenico
authors.initials: D
authors.lastname: Palli
authors.forename: Claudia
authors.initials: C
authors.lastname: Agnoli
authors.forename: Rosario
authors.initials: R
authors.lastname: Tumino
authors.forename: Silvia
authors.initials: S
authors.lastname: Polidoro
authors.forename: Amalia
authors.initials: A
authors.lastname: Mattiello
authors.forename: H Bas
authors.initials: HB
authors.lastname: Bueno-de-Mesquita
authors.forename: Petra H
authors.initials: PH
authors.lastname: Peeters
authors.forename: Elisabete
authors.initials: E
authors.lastname: Weiderpass
authors.forename: Eiliv
authors.initials: E
authors.lastname: Lund
authors.forename: Guri
authors.initials: G
authors.lastname: Skeie
authors.forename: Laudina
authors.initials: L
authors.lastname: Rodríguez
authors.forename: Noemie
authors.initials: N
authors.lastname: Travier
authors.forename: Maria-José
authors.initials: MJ
authors.lastname: Sánchez
authors.forename: Pilar
authors.initials: P
authors.lastname: Amiano
authors.forename: José-María
authors.initials: JM
authors.lastname: Huerta
authors.forename: Eva
authors.initials: E
authors.lastname: Ardanaz
authors.forename: Torgny
authors.initials: T
authors.lastname: Rasmuson
authors.forename: Göran
authors.initials: G
authors.lastname: Hallmans
authors.forename: Martin
authors.initials: M
authors.lastname: Almquist
authors.forename: Jonas
authors.initials: J
authors.lastname: Manjer
authors.forename: Konstantinos K
authors.initials: KK
authors.lastname: Tsilidis
authors.forename: Naomi E
authors.initials: NE
authors.lastname: Allen
authors.forename: Kay-Tee
authors.initials: KT
authors.lastname: Khaw
authors.forename: Nick
authors.initials: N
authors.lastname: Wareham
authors.forename: Graham
authors.initials: G
authors.lastname: Byrnes
authors.forename: Isabelle
authors.initials: I
authors.lastname: Romieu
authors.forename: Elio
authors.initials: E
authors.lastname: Riboli
authors.forename: Silvia
authors.initials: S
authors.lastname: Franceschi
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D049628:Body Size; D015331:Cohort Studies; D005060:Europe; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012306:Risk; D013964:Thyroid Neoplasms / Q000209:etiology*; D049629:Waist-Hip Ratio