title: Tannins, peptic ulcers and related mechanisms.
abstract: This review of the current literature aims to study correlations between the chemical structure and gastric anti-ulcer activity of tannins. Tannins are used in medicine primarily because of their astringent properties. These properties are due to the fact that tannins react with the tissue proteins with which they come into contact. In gastric ulcers, this tannin-protein complex layer protects the stomach by promoting greater resistance to chemical and mechanical injury or irritation. Moreover, in several experimental models of gastric ulcer, tannins have been shown to present antioxidant activity, promote tissue repair, exhibit anti Helicobacter pylori effects, and they are involved in gastrointestinal tract anti-inflammatory processes. The presence of tannins explains the anti-ulcer effects of many natural products.
authors.affiliation: Department of Pharmaceutical Sciences, Federal University of Paraiba, João Pessoa 58051-970, PB, Brazil.
authors.forename: Neyres Zinia Taveira
authors.initials: NZT
authors.lastname: De Jesus
authors.affiliation: Department of Pharmaceutical Sciences, Federal University of Paraiba, João Pessoa 58051-970, PB, Brazil.
authors.forename: Heloina de Souza
authors.initials: HS
authors.lastname: Falcão
authors.affiliation: Department of Pharmaceutical Sciences, Federal University of Paraiba, João Pessoa 58051-970, PB, Brazil.
authors.forename: Isis Fernandes
authors.initials: IF
authors.lastname: Gomes
authors.affiliation: Department of Pharmaceutical Sciences, Federal University of Paraiba, João Pessoa 58051-970, PB, Brazil.
authors.forename: Thiago Jose de Almeida
authors.initials: TJA
authors.lastname: Leite
authors.affiliation: Department of Pharmaceutical Sciences, Federal University of Paraiba, João Pessoa 58051-970, PB, Brazil.
authors.forename: Gedson Rodrigues de Morais
authors.initials: GRM
authors.lastname: Lima
authors.affiliation: Department of Pharmaceutical Sciences, Federal University of Paraiba, João Pessoa 58051-970, PB, Brazil.
authors.forename: Jose Maria
authors.initials: JM
authors.lastname: Barbosa-Filho
authors.affiliation: Department of Pharmaceutical Sciences, Federal University of Paraiba, João Pessoa 58051-970, PB, Brazil.
authors.forename: Josean Fechine
authors.initials: JF
authors.lastname: Tavares
authors.affiliation: Department of Pharmaceutical Sciences, Federal University of Paraiba, João Pessoa 58051-970, PB, Brazil.
authors.forename: Marcelo Sobral da
authors.initials: MSD
authors.lastname: Silva
authors.affiliation: Department of Pharmaceutical Sciences, Federal University of Paraiba, João Pessoa 58051-970, PB, Brazil.
authors.forename: Petrônio Filgueiras de
authors.initials: PF
authors.lastname: Athayde-Filho
authors.affiliation: Department of Pharmaceutical Sciences, Federal University of Paraiba, João Pessoa 58051-970, PB, Brazil.
authors.forename: Leonia Maria
authors.initials: LM
authors.lastname: Batista
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000897:Anti-Ulcer Agents / Q000737:chemistry / Q000494:pharmacology*; D016481:Helicobacter Infections / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D016480:Helicobacter pylori / Q000187:drug effects; D006801:Humans; D010437:Peptic Ulcer / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D064209:Phytochemicals / Q000737:chemistry / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013634:Tannins / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000897:Anti-Ulcer Agents; D064209:Phytochemicals; D010936:Plant Extracts; D013634:Tannins