title: Developing S-phase control.
abstract: The duration of S phase in early embryos is often short, and then increases as development proceeds because of the appearance of late-replicating regions of the genome. In the April 1, 2012, issue of Genes & Development, Farrell and colleagues (pp. 714-725) demonstrate that the down-regulation of cyclin-dependent kinase 1 (Cdk1) activity triggers the onset of late-replicating DNA and an increase in S-phase length in Drosophila embryos, revealing an unexpected role for Cdk1 in replication control during development.
authors.affiliation: Department of Biology, Department of Genetics, Lineberger Comprehensive Cancer Center, Program in Molecular Biology and Biotechnology, University of North Carolina, Chapel Hill, NC 27599, USA. duronio@med.unc.edu
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Duronio
mesh_terms: D000818:Animals; D016203:CDC2 Protein Kinase / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000502:physiology*; D004261:DNA Replication; D004331:Drosophila melanogaster / Q000196:embryology / Q000201:enzymology / Q000235:genetics; D004625:Embryo, Nonmammalian / Q000166:cytology / Q000201:enzymology; D047108:Embryonic Development / Q000235:genetics*; D016196:S Phase / Q000235:genetics*
chemical_list: D016203:CDC2 Protein Kinase