title: Heparin--a key drug in the treatment of the circulatory degenerative diseases: controlling its action with polymers.
abstract: The properties of heparin, a key anticoagulant, are reviewed. The important issues in heparinotherapy, i.e., reaching quick anticoagulant effect, maintaining therapeutic level of anticoagulation, heparin inhibition and non-invasive heparin formulations have been reviewed and discussed, with the focus on the role of polymeric substances in the proposed solutions.
authors.affiliation: Faculty of Chemistry, Jagiellonian University, Kraków, Poland. szczubia@chemia.uj.edu.pl
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Szczubiałka
authors.forename: Kamil
authors.initials: K
authors.lastname: Kamiński
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Zasada
authors.forename: Anna
authors.initials: A
authors.lastname: Karewicz
authors.forename: Maria
authors.initials: M
authors.lastname: Nowakowska
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*; D003692:Delayed-Action Preparations; D004337:Drug Carriers / Q000737:chemistry*; D006470:Hemorrhage / Q000517:prevention & control; D006493:Heparin / Q000008:administration & dosage / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*; D006494:Heparin Antagonists / Q000627:therapeutic use; D006801:Humans; D015394:Molecular Structure; D019636:Neurodegenerative Diseases / Q000097:blood / Q000188:drug therapy*; D011108:Polymers / Q000737:chemistry*
chemical_list: D000925:Anticoagulants; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D006494:Heparin Antagonists; D011108:Polymers; D006493:Heparin