title: Correlation between thyroid autoantibodies and intracranial arterial stenosis in stroke patients with hyperthyroidism.
abstract: We performed a retrospective case review of stroke patients with diagnosis of hyperthyroidism admitted in our hospital from January 2008 to December 2010. We reviewed their routine assessments of intracranial and extracranial arteries or heart and then compared the demographic profiles, thryroid function test, and thyroid autoantibody status between stroke patients with and without intracranial stenosis. We also compared the baseline characteristics, thyroid function test (TFT), and prevalence of intracranial arterial stenosis between patients with or without elevated TPO-Ab level. We use the Wicoxon rank sum test for nonparametric and Fisher's exact test for categorical comparisons. A total of 17 acute ischemic stroke patients with hyperthyroidism were included and 8 (47.0%) patients was found to have intracranial stenosis. The patients with intracranial stenosis had a higher prevalence of elevated antithyroperoxidase antibody (TPO-Ab), compared with those without intracranial stenosis (100% versus 33.3%, p=0.004), while thyroid function tests were not significantly different between two groups. So we come to the conclusion that elevated thyroid autoantibody, especially TPO-Ab, is associated with the development of intracranial stenosis in hyperthyroid patients and therefore monitoring of intracranial vessels is suggested in hyperthyroid patients with high level of thyroid autoantibodies.
authors.affiliation: Department of Neurology, The 2nd Affiliated Hospital of Zhejiang University, School of Medicine, Hangzhou, China.
authors.forename: Xuting
authors.initials: X
authors.lastname: Zhang
authors.forename: Zhicai
authors.initials: Z
authors.lastname: Chen
authors.forename: Zhenghao
authors.initials: Z
authors.lastname: Shi
authors.forename: Min
authors.initials: M
authors.lastname: Lou
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000096:biosynthesis* / Q000097:blood; D001327:Autoimmune Diseases / Q000453:epidemiology* / Q000276:immunology / Q000503:physiopathology; D002561:Cerebrovascular Disorders / Q000453:epidemiology* / Q000276:immunology / Q000503:physiopathology; D015897:Comorbidity; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000453:epidemiology* / Q000276:immunology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D020521:Stroke / Q000453:epidemiology* / Q000276:immunology / Q000503:physiopathology
chemical_list: D001323:Autoantibodies