title: Screening and identification of various components in Thalictrum fortunei using a combination of liquid chromatography/time-of-flight tandem mass spectrometry.
abstract: An approach for screening and identification of various components in a traditional Chinese medicine (TCM), using a combination of LC/TOF-MS technique was described in this paper. The chemical profile of Thalictrum fortunei, well-known in TCM, was studied using the established method. The possibilities of screening and identifying non-target components inside TCM with modern data acquisition methods of acceleration time of flight mass spectrometers, such as data-dependent MS to MS/MS switching were investigated. As a result, 27 components were identified. This study was aimed to screen and identify the main components of T. fortunei using LC/TOF-MS, expecting to provide a rapid, sensitive, economical and systematical method for the identification and further quality evaluation of TCM preparation.
authors.affiliation: Department of Traditional Chinese Medicine, Zhejiang Institute for Food and Drug Control, Hangzhou, P. R. of China.
authors.forename: H X
authors.initials: HX
authors.lastname: Cheng
authors.forename: Y C
authors.initials: YC
authors.lastname: Zeng
authors.forename: B Y
authors.initials: BY
authors.lastname: Jia
authors.forename: C F
authors.initials: CF
authors.lastname: Fang
authors.forename: W M
authors.initials: WM
authors.lastname: Cheng
mesh_terms: D000470:Alkaloids / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D007202:Indicators and Reagents; D007546:Isoquinolines / Q000737:chemistry; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D053719:Tandem Mass Spectrometry; D031949:Thalictrum / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D007202:Indicators and Reagents; D007546:Isoquinolines