title: Serum lactate dehydrogenase levels significantly correlate with radiological extent of disease and spirometric values in patients with silicosis due to denim sandblasting.
abstract: BACKGROUND
  The aim of the present study was to investigate serum lactate dehydrogenase (LD) levels in patients with silicosis due to denim sandblasting (SDDS) and also to investigate possible correlations between serum LD levels and the degree of radiological extent of disease (RED) and pulmonary function tests.
  
  
  METHODS
  Forty-four males with SDDS and 32 healthy male subjects were included in the study. Patients and healthy controls were compared for serum LD levels. Correlations between serum LD levels, RED and spirometric values were investigated.
  
  
  RESULTS
  Patients with SDDS had significantly higher serum LD levels than healthy controls. Patients with complicated SDDS had significantly higher serum LD levels than patients with simple SDDS. Significant correlations were found between serum LD levels and RED values. Significant correlations were found between serum LD levels and spirometric parameters.
  
  
  CONCLUSIONS
  High serum LD levels might be considered as a marker of pulmonary parenchymal involvement in patients with SDDS. This study also suggests that the increase in serum LD levels might be closely related to the degree of pulmonary involvement in SDDS patients.
authors.affiliation: Department of Pulmonary Medicine, Gulhane Military Medical Academy, Ankara, Turkey. omerdeniz@yahoo.com
authors.forename: Omer
authors.initials: O
authors.lastname: Deniz
authors.forename: Seyfettin
authors.initials: S
authors.lastname: Gumus
authors.forename: Fatih
authors.initials: F
authors.lastname: Ors
authors.forename: Halil
authors.initials: H
authors.lastname: Yaman
authors.forename: Bilal
authors.initials: B
authors.lastname: Battal
authors.forename: Bulent
authors.initials: B
authors.lastname: Karaman
authors.forename: Cengiz Han
authors.initials: CH
authors.lastname: Acikel
authors.forename: Ergun
authors.initials: E
authors.lastname: Ucar
authors.forename: Erdinc
authors.initials: E
authors.lastname: Cakir
authors.forename: Ergun
authors.initials: E
authors.lastname: Tozkoparan
authors.forename: Hayati
authors.initials: H
authors.lastname: Bilgic
mesh_terms: D016022:Case-Control Studies; D003020:Clothing; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D008297:Male; D011859:Radiography; D012822:Silicon Dioxide / Q000009:adverse effects*; D012829:Silicosis / Q000097:blood* / Q000000981:diagnostic imaging* / Q000209:etiology / Q000503:physiopathology; D013147:Spirometry; D055815:Young Adult
chemical_list: D012822:Silicon Dioxide; D007770:L-Lactate Dehydrogenase