title: RNAi in fission yeast finds new targets and new ways of targeting at the nuclear periphery.
abstract: RNAi in Schizosaccharomyces pombe is critical for centromeric heterochromatin formation. It has remained unclear, however, whether RNAi also regulates the expression of protein-coding loci. In the April 1, 2012, issue of Genes & Development, Woolcock and colleagues (pp. 683-667) reported an elegant mechanism for the conditional RNAi-mediated repression of stress response genes involving association with Dcr1 at the nuclear pore. Unexpectedly, the initial targeting of RNAi components to these genes does not require small RNA guides.
authors.affiliation: Department of Cell Biology, Howard Hughes Medical Institute, Harvard Medical School, Boston, MA 02115, USA.
authors.forename: Daniel
authors.initials: D
authors.lastname: Holoch
authors.forename: Danesh
authors.initials: D
authors.lastname: Moazed
mesh_terms: D051697:Activating Transcription Factor 1 / Q000378:metabolism*; D022022:Nuclear Pore / Q000378:metabolism*; D010750:Phosphoproteins / Q000378:metabolism*; D034622:RNA Interference; D012568:Schizosaccharomyces / Q000378:metabolism*; D029702:Schizosaccharomyces pombe Proteins / Q000378:metabolism*; D013312:Stress, Physiological
chemical_list: D051697:Activating Transcription Factor 1; D010750:Phosphoproteins; D029702:Schizosaccharomyces pombe Proteins