title: Why does the immune system of Atlantic cod lack MHC II?
abstract: MHC II, a major feature of the adaptive immune system, is lacking in Atlantic cod, and there are different scenarios (metabolic cost hypothesis or functional shift hypothesis) that might explain this loss. The lack of MHC II coincides with an increased number of genes for MHC I and Toll-like receptors (TLRs).
authors.affiliation: Centre for Ecological and Evolutionary Synthesis (CEES), Department of Biology, University of Oslo, Oslo, Norway. bastiaan.star@bio.uio.no
authors.forename: Bastiaan
authors.initials: B
authors.lastname: Star
authors.forename: Sissel
authors.initials: S
authors.lastname: Jentoft
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D001419:Bacteria / Q000254:growth & development / Q000276:immunology; D058448:Biota; D003080:Cold Temperature; D004777:Environment; D019143:Evolution, Molecular; D048389:Gadus morhua / Q000235:genetics / Q000276:immunology*; D005802:Genes, MHC Class II; D040961:Genetic Drift; D054884:Host-Pathogen Interactions; D012641:Selection, Genetic; D013045:Species Specificity; D051193:Toll-Like Receptors / Q000276:immunology
chemical_list: D051193:Toll-Like Receptors