title: Stereoselective hydrofluorination of ynamides: a straightforward synthesis of novel α-fluoroenamides.
abstract: α-Fluoroenamides, potent rigid fluorinated bioisosters of ureas, have been synthesized by a highly regio- and stereo-selective hydrofluorination of ynamides in anhydrous HF. This reaction provides the first general entry to α-fluoroenamides and can easily be applied to a wide range of substrates.
authors.affiliation: Superacid group in Glycochimie, Superacide et Chimie des systèmes team - Université de Poitiers, CNRS UMR 7285 IC2MP, 4, avenue Michel Brunet, F-86022 Poitiers Cedex, France.
authors.forename: Guillaume
authors.initials: G
authors.lastname: Compain
authors.forename: Kevin
authors.initials: K
authors.lastname: Jouvin
authors.forename: Agnès
authors.initials: A
authors.lastname: Martin-Mingot
authors.forename: Gwilherm
authors.initials: G
authors.lastname: Evano
authors.forename: Jérome
authors.initials: J
authors.lastname: Marrot
authors.forename: Sébastien
authors.initials: S
authors.lastname: Thibaudeau
mesh_terms: D000577:Amides / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D054879:Halogenation; D006858:Hydrofluoric Acid / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry; D000644:Quaternary Ammonium Compounds / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000577:Amides; D011725:Pyridines; D000644:Quaternary Ammonium Compounds; C023666:pyridine; D006858:Hydrofluoric Acid