title: [A comparative analysis of three diagnostic criteria for multiple myeloma].
abstract: OBJECTIVE
  To compare the sensitivity among three diagnostic criteria for multiple myeloma.
  
  
  METHODS
  A total of 220 patients with multiple myeloma were studied retrospectively to compare the sensitivity, as well as their clinical manifestations, cell morphology in bone marrow and immunophenotype.
  
  
  RESULTS
  (1) The sensitivity of domestic diagnostic criterion in 1975 was 79.1% (174/220) and there were some drawbacks in type identify. The sensitivity of WHO diagnostic criterion in 2001 was 97.3% (214/220) and the sensitivity of domestic diagnostic criteria in 2011 was 100%. (2) Immunoglobulin level in 12.7% (28/220) patients was < 30 g/L, plasma cells count in bone marrow in 13.6% (30/220) was < 10%; 2.7% (6/220) patients had not met the standard in immunity globulin and bone marrow plasma cells count. (3) The immunophenotype was CD(38) positive (100%), restricted light chain (kappa/lambda) and CD(19)100%, CD(138) (98.2%, 216/220) negative.
  
  
  CONCLUSIONS
  Among the three diagnostic criteria, the highest was 2011 domestic diagnostic criteria. Comprehensive analysis include clinical manifestations, cell morphology, immunophenotype will contribute to the diagnosis for multiple myeloma.
authors.affiliation: Peking University People's Hospital, Institute of Hematology, Beijing, China.
authors.forename: Jin
authors.initials: J
authors.lastname: Lu
authors.forename: Xiao-jun
authors.initials: XJ
authors.lastname: Huang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001854:Bone Marrow Cells / Q000166:cytology; D042241:Early Diagnosis; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007147:Immunoglobulin Light Chains; D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains; D016130:Immunophenotyping; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000175:diagnosis* / Q000276:immunology; D010950:Plasma Cells / Q000166:cytology; D012015:Reference Standards; D012189:Retrospective Studies
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007147:Immunoglobulin Light Chains; D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains