title: Temporal trends in Bordetella pertussis populations, Denmark, 1949-2010.
abstract: We used multilocus variable-number tandem repeat analysis and multiple antigen sequence typing to characterize isolates of Bordetella pertussis strains circulating in Denmark during periods with and without pertussis vaccination coverage. Our results show substantial shifts in the B. pertussis population over time and a reduction in genetic diversity. These changes might have resulted from the introduction of pertussis vaccines in Denmark and other parts of Europe. The predominant strains currently circulating in Denmark resemble those in other European countries.
authors.affiliation: Statens Serum Institut, Copenhagen, Denmark. rfp@ssi.dk
authors.forename: Randi Føns
authors.initials: RF
authors.lastname: Petersen
authors.forename: Tine
authors.initials: T
authors.lastname: Dalby
authors.forename: Ditte Marie
authors.initials: DM
authors.lastname: Dragsted
authors.forename: Frits
authors.initials: F
authors.lastname: Mooi
authors.forename: Lotte
authors.initials: L
authors.lastname: Lambertsen
mesh_terms: D000483:Alleles; D001886:Bordetella pertussis / Q000145:classification / Q000235:genetics*; D004269:DNA, Bacterial; D003718:Denmark; D005787:Gene Frequency; D014644:Genetic Variation; D006801:Humans; D058885:Multilocus Sequence Typing; D010567:Pertussis Vaccine / Q000276:immunology; D020080:Tandem Repeat Sequences; D014917:Whooping Cough / Q000517:prevention & control
chemical_list: D004269:DNA, Bacterial; D010567:Pertussis Vaccine