title: Thrombolysis with recombinant tissue plasminogen activator in 7 children.
abstract: The information about the thromboembolic events, the optimal treatment choice, the dose, and duration of antithrombotic therapy in children are limited. More clinical data are required. Recombinant tissue plasminogen activator (r-tPA) is increasingly used in pediatric thrombosis. We retrospectively analyzed the clinical course of 7 children (9.3 ± 2.1 years; 34 days to 16 years) with arterial thrombosis (n = 1) and intracardiac thrombosis (n = 6). The children were treated with r-tPA. The dose ranged between 0.2 and 0.4 mg/kg per h infused for 3 to 4 hours. This dose was repeated between 2 to 7 times till the thrombolysis was achieved. Treatment side effects were closely monitored. Complete clot lysis was achieved in all cases. None of them had severe bleeding except mild recurrent epistaxis occurring in 2 cases. In conclusion, r-tPA is an effective and safe therapy under close hemostatic control in children.
authors.affiliation: 1Division of Pediatric Hematology, Department of Pediatrics, Medical Faculty of Uludag, Nilüfer, Bursa, Turkey.
authors.forename: Melike Sezgin
authors.initials: MS
authors.lastname: Evim
authors.forename: Özlem
authors.initials: Ö
authors.lastname: Bostan
authors.forename: Birol
authors.initials: B
authors.lastname: Baytan
authors.forename: Evren
authors.initials: E
authors.lastname: Semizel
authors.forename: Adalet Meral
authors.initials: AM
authors.lastname: Günes
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D008297:Male; D012189:Retrospective Studies; D013927:Thrombosis / Q000188:drug therapy*; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator