title: Arthralgia during aromatase inhibitor treatment in early breast cancer patients: prevalence, impact, and recognition by healthcare providers.
abstract: BACKGROUND
  Many breast cancer patients experience arthralgia symptoms during aromatase inhibitor (AI) treatment, which leads to poor compliance and a lower quality of life.
  
  
  OBJECTIVE
  The research questions of this study were as follows: (1) What is the incidence of arthralgia during AI treatment in early breast cancer patients, (2) what is the impact of AI-associated arthralgia on hand function, daily activities, and AI adherence, and (3) does the healthcare provider recognize AI-associated arthralgia as relevant in clinical practice?
  
  
  METHODS
  A total of 57 breast cancer patients of a University Breast Cancer Clinic participated in this study. Each patient completed a questionnaire, performed 2 function tests (goniometry of the wrist and a handgrip strength measurement), and consented to a review of the medical chart.
  
  
  RESULTS
  Forty-two breast cancer patients (74%) reported symptoms of arthralgia. All patients with arthralgia symptoms experienced an impact on their daily activities, and 65% had a decrease in hand and finger function. Sixty-nine percent of all patients were fully adherent in their medicine treatment. In 26% of cases with arthralgia, the symptoms were not reported in the medical chart.
  
  
  CONCLUSIONS
  Given the large number of patients with AI-associated arthralgia and its impact on daily life and functioning, it is of great importance to improve the recognition and care of arthralgia symptoms during AI treatment.
  
  
  CONCLUSIONS
  Oncology nurses could play an important role in assessment of modifiable risk factors, providing lifestyle advice and support in coping.
authors.affiliation: Department of Medical Oncology, Radboud University, The Netherlands.
authors.forename: Amilie
authors.initials: A
authors.lastname: Boonstra
authors.forename: Joost
authors.initials: J
authors.lastname: van Zadelhoff
authors.forename: Anja
authors.initials: A
authors.lastname: Timmer-Bonte
authors.forename: Petronella B
authors.initials: PB
authors.lastname: Ottevanger
authors.forename: Carien H G
authors.initials: CH
authors.lastname: Beurskens
authors.forename: Hanneke W M
authors.initials: HW
authors.lastname: van Laarhoven
mesh_terms: D000368:Aged; D047072:Aromatase Inhibitors / Q000009:adverse effects*; D018771:Arthralgia / Q000139:chemically induced* / Q000175:diagnosis; D001943:Breast Neoplasms / Q000188:drug therapy*; D005260:Female; D018737:Hand Strength / Q000502:physiology; D006282:Health Personnel; D006801:Humans; D008875:Middle Aged; D010147:Pain Measurement; D014953:Wrist / Q000502:physiology; D016903:Drug Monitoring
chemical_list: D047072:Aromatase Inhibitors