title: Protective effect of sauchinone on methamphetamine-induced neurotoxicity in mice.
abstract: Sauchinone is a lignan isolated from Saururus chinensis known to suppress nitric oxide (NO) activity. Previous studies demonstrate that NO plays a key role in methamphetamine-induced neurotoxicity. Thus, we hypothesized that sauchinone could have a suppressive effect on the neurotoxicity induced by methamphetamine. Repeated injections of methamphetamine cause degeneration of dopaminergic nerve terminals, whereas sauchinone treatment significantly prevented this degeneration. Sauchinone treatment also inhibited the methamphetamine-induced activation of glia cells and the production of NO via a blockade of inducible NO synthase protein expression. Our results suggest that sauchinone can prevent methamphetamine-induced neurotoxicity through the suppression of NO production.
authors.affiliation: Department of Oriental Medicine, College of Oriental Medicine, Daegu Haany University, Daegu, South Korea.
authors.forename: Eun Young
authors.initials: EY
authors.lastname: Jang
authors.forename: Kyung Ah
authors.initials: KA
authors.lastname: Park
authors.forename: Jong Rock
authors.initials: JR
authors.lastname: Lee
authors.forename: Chae Ha
authors.initials: CH
authors.lastname: Yang
authors.forename: Meeyul
authors.initials: M
authors.lastname: Hwang
mesh_terms: D000818:Animals; D001578:Benzopyrans / Q000494:pharmacology / Q000627:therapeutic use*; D004149:Dioxoles / Q000494:pharmacology / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D017705:Lignans / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008694:Methamphetamine / Q000633:toxicity*; D051379:Mice; D008810:Mice, Inbred C57BL; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D020258:Neurotoxicity Syndromes / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000378:metabolism; D052247:Nitric Oxide Synthase Type II / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D001578:Benzopyrans; D004149:Dioxoles; D017705:Lignans; D018696:Neuroprotective Agents; C410958:sauchinone; D009569:Nitric Oxide; D008694:Methamphetamine; D052247:Nitric Oxide Synthase Type II