title: Synthesis and biological evaluation of nojirimycin- and pyrrolidine-based trehalase inhibitors.
abstract: A small set of nojirimycin- and pyrrolidine-based iminosugar derivatives has been synthesized and evaluated as potential inhibitors of porcine and insect trehalases. Compounds 12, 13 and 20 proved to be active against both insect and porcine trehalases with selectivity towards the insect glycosidase, while compounds 10, 14 and 16 behaved as inhibitors only of insect trehalase. Despite the fact that the activity was found in the micromolar range, these findings may help in elucidating the structural features of this class of enzymes of different origin, which are still scarcely characterised.
authors.affiliation: Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, 20126 Milano, Italy.
authors.forename: Davide
authors.initials: D
authors.lastname: Bini
authors.forename: Francesca
authors.initials: F
authors.lastname: Cardona
authors.forename: Matilde
authors.initials: M
authors.lastname: Forcella
authors.forename: Camilla
authors.initials: C
authors.lastname: Parmeggiani
authors.forename: Paolo
authors.initials: P
authors.lastname: Parenti
authors.forename: Francesco
authors.initials: F
authors.lastname: Nicotra
authors.forename: Laura
authors.initials: L
authors.lastname: Cipolla