title: Bicyclic peptides with optimized ring size inhibit human plasma kallikrein and its orthologues while sparing paralogous proteases.
authors.affiliation: Institute of Chemical Sciences and Engineering (ISIC), Ecole Polytechnique Fédérale de Lausanne (EPFL), CH B3 391, Station 6, 1015 Lausanne, Switzerland.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Baeriswyl
authors.forename: Helen
authors.initials: H
authors.lastname: Rapley
authors.forename: Lisa
authors.initials: L
authors.lastname: Pollaro
authors.forename: Catherine
authors.initials: C
authors.lastname: Stace
authors.forename: Dan
authors.initials: D
authors.lastname: Teufel
authors.forename: Edward
authors.initials: E
authors.lastname: Walker
authors.forename: Shiyu
authors.initials: S
authors.lastname: Chen
authors.forename: Greg
authors.initials: G
authors.lastname: Winter
authors.forename: John
authors.initials: J
authors.lastname: Tite
authors.forename: Christian
authors.initials: C
authors.lastname: Heinis
mesh_terms: D000818:Animals; D001643:Bridged Bicyclo Compounds / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D051379:Mice; D008958:Models, Molecular; D010447:Peptide Hydrolases / Q000378:metabolism*; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D020842:Plasma Kallikrein / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D001643:Bridged Bicyclo Compounds; D004791:Enzyme Inhibitors; D010456:Peptides, Cyclic; D010447:Peptide Hydrolases; D020842:Plasma Kallikrein