title: [Pharmacokinetics and tissue distribution of Schisandra chinensis extract in mice].
abstract: OBJECTIVE
  To investigate the pharmacokinetics and tissue distribution of Schisandra chinensis in mice.
  
  
  METHODS
  Schisandrin in mice plasma and tissues including heart, liver, spleen, lung and kidney was quantitatively determined by HPLC.
  
  
  RESULTS
  The concentration-time curve of Schisandra chinensis extract was described by a single compartment model, Cmax was (2.17 +/- 0.27) mg/ mL, t(max) was (1.00 +/- 0.32) h, AUC0-->infinity, was (4.07 +/- 0.62) mg x h/mL. The sequence of distribution of schisandrin in mice body was as follows: liver > plasma > kidney > lung > heart > spleen.
  
  
  CONCLUSIONS
  The distribution of extract in the body is abroad. Liver has relative high concentration of schisandrin, which is beneficial to the treatment of hepatic disease.
authors.affiliation: College of Pharmacy, Jilin Medical College, Jilin 132013, China. rainbowguanjiao@sina.com
authors.forename: Jiao
authors.initials: J
authors.lastname: Guan
authors.forename: He-Yun
authors.initials: HY
authors.lastname: Zhu
authors.forename: Xiu-Rong
authors.initials: XR
authors.lastname: Zhang
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhao
authors.forename: De-Yi
authors.initials: DY
authors.lastname: Sun
mesh_terms: D000284:Administration, Oral; D000818:Animals; D019540:Area Under Curve; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D034242:Cyclooctanes / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics*; D005638:Fruit / Q000737:chemistry; D007668:Kidney / Q000378:metabolism; D017705:Lignans / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics*; D008099:Liver / Q000378:metabolism*; D008168:Lung / Q000378:metabolism; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000097:blood / Q000493:pharmacokinetics*; D011083:Polycyclic Compounds / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics*; D032141:Schisandra / Q000737:chemistry*; D013154:Spleen / Q000378:metabolism; D014018:Tissue Distribution
chemical_list: D034242:Cyclooctanes; D017705:Lignans; D010936:Plant Extracts; D011083:Polycyclic Compounds; C011105:schizandrin