title: Effects of pulsed infra-red low level-laser irradiation on open skin wound healing of healthy and streptozotocin-induced diabetic rats by biomechanical evaluation.
abstract: Diabetes is one of the most common causes of delayed wound healing. Low-level laser therapy (LLLT) are one of the therapeutic modalities used for the treatment of wounds. The aim of present study is to evaluate the effect of LLLT in experimentally-induced diabetic rats. Two full thickness skin incisions were made on dorsal regions of each rat. The wounds were randomly divided into laser-treated and placebo. Laser-treated wounds of the healthy (non-diabetic) animals were submitted to a pulsed-infrared 890nm laser with an 80Hz frequency and 0.03J/cm(2) for each wound point in the first healthy group and 0.2J/cm(2) in the second healthy group. Laser-treated wounds of the diabetic animals received the same pulsed-infrared laser treatments as the second group for each wound point. On day 15, a sample from each wound was extracted and submitted for tensile strength evaluation. Laser irradiation with 0.03J/cm(2) significantly decreased the maximum load for wound repair in healthy rats (p=0.015). Laser irradiation with 0.2J/cm(2) significantly increased the maximum load in wounds from the healthy control (p=0.021) and diabetic (p<001) groups. Laser treatments with a pulsed infrared laser at 0.2J/cm(2) significantly accelerated wound healing in both healthy and diabetic rats.
authors.affiliation: Department of Pathology, Army University of Medical Sciences, Tehran, Iran. dadpay_m@yahoo.com
authors.forename: Masoomeh
authors.initials: M
authors.lastname: Dadpay
authors.forename: Zanelabedien
authors.initials: Z
authors.lastname: Sharifian
authors.forename: Mohammad
authors.initials: M
authors.lastname: Bayat
authors.forename: Mehrnoush
authors.initials: M
authors.lastname: Bayat
authors.forename: Ali
authors.initials: A
authors.lastname: Dabbagh
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D003921:Diabetes Mellitus, Experimental; D004195:Disease Models, Animal; D028022:Low-Level Light Therapy; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000473:pathology* / Q000528:radiation effects; D014945:Wound Healing / Q000528:radiation effects*