title: Perspectives on the development of novel potentially active quinolones against tuberculosis and cancer.
abstract: Quinolones and its derivatives comprise an important group of heterocyclic compounds that exhibit a wide range of pharmacological properties such as antibacterial, antitumor, antiviral, anti-ischemic, antiparasitic and anxiolytic. Persistent efforts have been made over the years to develop novel congeners with superior biological activities and minimal potential for undesirable side-effects. The present review aims to highlight some recent discoveries on the development of novel quinolone-based compounds with potential antitubercular and anticancer activity.
authors.affiliation: Universidade Federal Fluminense, Instituto de Quimica, Departamento de Quimica Organica, Programa de Pos-Graduacao em Quimica. Outeiro de Sao Joao Batista, s/no, Centro, Niteroi, 24020-141, Rio de Janeiro, Brazil.
authors.forename: V
authors.initials: V
authors.lastname: Facchinetti
authors.forename: C R B
authors.initials: CR
authors.lastname: Gomes
authors.forename: M V N
authors.initials: MV
authors.lastname: de Souza
authors.forename: T R A
authors.initials: TR
authors.lastname: Vasconcelos
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D000995:Antitubercular Agents / Q000737:chemistry* / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D015195:Drug Design; D055808:Drug Discovery / Q000639:trends*; D006801:Humans; D051379:Mice; D050296:Microbial Viability / Q000187:drug effects; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000254:growth & development; D009369:Neoplasms / Q000188:drug therapy; D015363:Quinolones / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents; D000995:Antitubercular Agents; D015363:Quinolones