title: Design, synthesis, and primary activity evaluation of pyrrolidine derivatives as matrix metalloproteinase inhibitors.
abstract: A series of novel pyrrolidine derivatives was designed, synthesized, and assayed to determine the derivatives' activity against matrix metalloproteinase-2 (MMP-2) and aminopeptidase N (APN)/CD13. Preliminary biological tests showed that most compounds inhibit MMP-2 in a highly selective manner compared to APN. Compounds 9d, 9e, and 9g had better inhibitory activity than LY52 and could be used as lead compounds in the future.
authors.affiliation: Department of Medicinal Chemistry, School of Pharmacy, Shandong University, Ji'nan, Shandong, China.
authors.forename: J
authors.initials: J
authors.lastname: Zhang
authors.forename: X
authors.initials: X
authors.lastname: Li
authors.forename: H W
authors.initials: HW
authors.lastname: Zhu
authors.forename: Q
authors.initials: Q
authors.lastname: Wang
authors.forename: J H
authors.initials: JH
authors.lastname: Feng
authors.forename: J J
authors.initials: JJ
authors.lastname: Mou
authors.forename: Y G
authors.initials: YG
authors.lastname: Li
authors.forename: H
authors.initials: H
authors.lastname: Fang
authors.forename: W F
authors.initials: WF
authors.lastname: Xu