title: [Pneumococcal serotypes in carrier children prior to the introduction of anti-pneumococcal vaccines in Peru].
abstract: OBJECTIVE
  To determine the carriage rate and serotype distribution of Streptococcus pneumoniae in the nasopharynx of healthy children younger than 2 years prior to the universal use of the pneumococcal conjugate vaccines in Peru.
  
  
  METHODS
  Between 2007 and 2009 we collected nasopharyngeal swab samples from 2,123 healthy children aged 2 to 24 months in the vaccination and healthy children consultation offices of pediatric hospitals and health centers in 7 cities in Peru: on the coast (Lima, Piura), highlands (Cusco, Abancay, Arequipa and Huancayo) and amazon basin (Iquitos). The pneumococcal strains were isolated and identified at the central laboratory of the project in Lima, and serotyped by Quellung reaction in the pneumococcal reference laboratory at the Center for Diseases Control and Prevention (CDC).
  
  
  RESULTS
  We found 27% (573/2123) of pneumococcal nasopharyngeal healthy carrier children. Among the 526 analyzed strains, we found 42 serotypes; the most common were: 19F (18.1%), 6B (14.3%); 23F (8.9%) and 14 (6.5%).
  
  
  CONCLUSIONS
  The distribution of vaccine serotypes in the analyzed strains was of 50% for the serotypes present in the seven-valent vaccine, 50.2% for the serotypes present in the ten-valent vaccine and 57.2% for those present in the thirteen-valent vaccine.
authors.affiliation: Universidad Peruana Cayetano Heredia, Lima, Perú.
authors.forename: Erik H
authors.initials: EH
authors.lastname: Mercado
authors.forename: Martha
authors.initials: M
authors.lastname: Egoavil
authors.forename: Sara G
authors.initials: SG
authors.lastname: Horna
authors.forename: Nancy
authors.initials: N
authors.lastname: Torres
authors.forename: Ricardo
authors.initials: R
authors.lastname: Velásquez
authors.forename: María E
authors.initials: ME
authors.lastname: Castillo
authors.forename: Eduardo
authors.initials: E
authors.lastname: Chaparro
authors.forename: Roger
authors.initials: R
authors.lastname: Hernández
authors.forename: Wilda
authors.initials: W
authors.lastname: Silva
authors.forename: Francisco E
authors.initials: FE
authors.lastname: Campos
authors.forename: Andrés
authors.initials: A
authors.lastname: Sáenz
authors.forename: Félix
authors.initials: F
authors.lastname: Hidalgo
authors.forename: Carolina
authors.initials: C
authors.lastname: Letona
authors.forename: Ángel G
authors.initials: ÁG
authors.lastname: Valencia
authors.forename: Rosario
authors.initials: R
authors.lastname: Cerpa
authors.forename: Bernardo
authors.initials: B
authors.lastname: López-de-Romaña
authors.forename: Jackeline
authors.initials: J
authors.lastname: Pando
authors.forename: Berenice
authors.initials: B
authors.lastname: Torres
authors.forename: Fiorella
authors.initials: F
authors.lastname: Castillo
authors.forename: Andrea
authors.initials: A
authors.lastname: Calle
authors.forename: Synthia
authors.initials: S
authors.lastname: Rabanal
authors.forename: Theresa J
authors.initials: TJ
authors.lastname: Ochoa
mesh_terms: D002353:Carrier State; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010568:Peru; D022242:Pneumococcal Vaccines; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification*
chemical_list: D022242:Pneumococcal Vaccines