title: New array approaches to explore single cells genomes.
abstract: Microarray analysis enables the genome-wide detection of copy number variations and the investigation of chromosomal instability. Whereas array techniques have been well established for the analysis of unamplified DNA derived from many cells, it has been more challenging to enable the accurate analysis of single cell genomes. In this review, we provide an overview of single cell DNA amplification techniques, the different array approaches, and discuss their potential applications to study human embryos.
authors.affiliation: Laboratory for Cytogenetics and Genome Research, Center for Human Genetics, Katholieke Universiteit Leuven, Universitair Ziekenhuis Gasthuisberg Leuven, Belgium.
authors.forename: Evelyne
authors.initials: E
authors.lastname: Vanneste
authors.forename: Lilach
authors.initials: L
authors.lastname: Bittman
authors.forename: Niels
authors.initials: N
authors.lastname: Van der Aa
authors.forename: Thierry
authors.initials: T
authors.lastname: Voet
authors.forename: Joris Robert
authors.initials: JR
authors.lastname: Vermeesch