title: Diastereoselective 1,3-dipolar cycloaddition of pyrylium ylides with chiral enamides.
abstract: Chiral enamides 5f-i were found to react with pyrylium ylides to give cycloadducts 6d-i in good yields with an excellent level of stereoselectivity. The chiral auxiliary was successfully removed on hydrogenolysis of compound 6f in continuous flow (H-Cube) resulting in the first asymmetric synthesis of complex amine 8.
authors.affiliation: School of Chemistry and Chemical Engineering, Queen's University Belfast, David Keir Building, Stranmillis Road, Belfast BT9 5AG, United Kingdom. k.tchabanenko@qub.ac.uk
authors.forename: Kirill
authors.initials: K
authors.lastname: Tchabanenko
authors.forename: Colleen
authors.initials: C
authors.lastname: Sloan
authors.forename: Yves-Mael
authors.initials: YM
authors.lastname: Bunetel
authors.forename: Philip
authors.initials: P
authors.lastname: Mullen