title: 5-Hydroxytryptamine Receptor Subtypes and their Modulators with Therapeutic Potentials.
abstract: 5-hydroxytryptamine (5-HT) has become one of the most investigated and complex biogenic amines. The main receptors and their subtypes, e.g., 5-HTI (5-HT1A, 5-HT1B, 5-HTID, 5-HTIE and 5-HT1F), 5-HT2 (5-HT2A, 5-HT2B and 5-HT2C), 5-HT3, 5-HT4, 5-HT5 (5-HT5A, 5-HT5B), 5-HT6 and 5-HT7 have been identified. Specific drugs which are capable of either selectively stimulating or inhibiting these receptor subtypes are being designed. This has generated therapeutic potentials of 5-HT receptor modulators in a variety of disease conditions. Conditions where 5-HT receptor modulators have established their use with distinct efficacy and advantages include migraine, anxiety, psychosis, obesity and cancer therapy-induced vomiting by cytotoxic drugs and radiation. Discovery of 5-HT, its biosynthesis, metabolism, physiological role and the potential of 5-HT receptor modulators in various nervous, cardiovascular and gastrointestinal tract disorders, bone growth and micturition have been discussed in this article.
  
  
  BACKGROUND
  5-hydroxytryptamine (5-HT) receptors; Modulators; Biogenic amines.
authors.affiliation: Department of pharmacology, L.M. College of Pharmacy, Navrangpura, Ahmedabad-3800 09, India.
authors.forename: Anand B
authors.initials: AB
authors.lastname: Pithadia
authors.forename: Sunita M
authors.initials: SM
authors.lastname: Jain