title: Management of retroperitoneal sarcomas: main prognostic factors for local recurrence and survival.
abstract: OBJECTIVE
  Retroperitoneal sarcomas (RPs) are characterized by slow indolent growth and metastasize at a late point in their natural course. The purpose of this study was to review our experience in the management of RSs and identify prognostic factors for local control and survival.
  
  
  METHODS
  Between January 1990 and December 2010, the hospital records of 75 patients with RSs were retrospectively studied. Sixty-four (85.3%) patients had undergone surgical resection in our hospital for primary RS, whereas 11 (14.7%) were referred to our department for recurrent disease.
  
  
  RESULTS
  The patient median age was 57 years. Median tumor size was 18.5 cm. The most common histologic type was liposarcoma (44%) followed by leiomyosarcoma (17%), paraganglioma (10%), malignant fibrous histiocytoma (6.5%) and rare tumors such as 2 chondrosarcomas and 1 pecoma. Complete initial resection with negative macroscopic margins (R0) was achieved in 39 (60.9%) patients. En bloc resection of adjacent organs was required in 8 (12.5%) patients with primary RS and in 8 (72.9%) with recurrent disease. Mortality rate was 4%. For the group of patients initially treated in our hospital, 1-year recurrence rate was 34.3%. The 3- and 5-year overall survival rates were 56.2% and 53.1%, respectively. Satellite tumors were recognised in 13 (20.3%) patients treated for primary RS, from whom 11 (84%) recurred within one year. Seven patients received adjuvant chemotherapy.
  
  
  CONCLUSIONS
  Radical surgical resection is the treatment of choice for patients with primary and locally recurrent RSs.
authors.affiliation: 2nd Department of Surgery, Aretaieion Hospital, University of Athens, Greece.
authors.forename: T
authors.initials: T
authors.lastname: Theodosopoulos
authors.forename: V
authors.initials: V
authors.lastname: Psychogiou
authors.forename: A I
authors.initials: AI
authors.lastname: Yiallourou
authors.forename: G
authors.initials: G
authors.lastname: Polymeneas
authors.forename: A
authors.initials: A
authors.lastname: Kondi-Pafiti
authors.forename: I
authors.initials: I
authors.lastname: Papaconstantinou
authors.forename: D
authors.initials: D
authors.lastname: Voros
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality; D011379:Prognosis; D012186:Retroperitoneal Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D012509:Sarcoma / Q000401:mortality / Q000473:pathology / Q000601:surgery*