title: Auras in temporal lobe epilepsy with hippocampal sclerosis: relation to seizure focus laterality and post surgical outcome.
abstract: We examined the relationship between presence and frequency of different types of auras and side of lesion and post surgical outcomes in 205 patients with medically intractable mesial temporal lobe epilepsy (MTLE) with unilateral hippocampal sclerosis (HS). With respect to the number of auras, multiple auras were not associated with side of lesion (p=0.551). The side of HS was not associated with the type of auras reported. One hundred fifty-seven patients were operated. The occurrence of multiple auras was not associated with post-surgical outcome (p=0.740). The presence of extratemporal auras was significantly higher in patients with poor outcome. In conclusion, this study suggests that the presence of extratemporal auras in patients with MTLE-HS possibly reflects extratemporal epileptogenicity in these patients, who otherwise showed features suggestive of TLE. Therefore, TLE-HS patients undergoing pre-surgical evaluation and presenting clinical symptoms suggestive of extratemporal involvement should be more extensively evaluated to avoid incomplete resection of the epileptogenic zone.
authors.affiliation: Departamento de Neurologia e Neurocirurgia, Universidade Federal de São Paulo, São Paulo, Brazil. taissaferrari@uol.com.br
authors.forename: Taíssa
authors.initials: T
authors.lastname: Ferrari-Marinho
authors.forename: Luís Otávio S F
authors.initials: LO
authors.lastname: Caboclo
authors.forename: Murilo M
authors.initials: MM
authors.lastname: Marinho
authors.forename: Ricardo S
authors.initials: RS
authors.lastname: Centeno
authors.forename: Rafael S C
authors.initials: RS
authors.lastname: Neves
authors.forename: Maria Teresa C G
authors.initials: MT
authors.lastname: Santana
authors.forename: Fernanda S
authors.initials: FS
authors.lastname: Brito
authors.forename: Henrique Carrete
authors.initials: HC
authors.lastname: Junior
authors.forename: Elza Márcia T
authors.initials: EM
authors.lastname: Yacubian
mesh_terms: D000293:Adolescent; D000328:Adult; D038481:Anterior Temporal Lobectomy / Q000379:methods*; D004827:Epilepsy / Q000145:classification / Q000209:etiology / Q000601:surgery*; D004833:Epilepsy, Temporal Lobe / Q000150:complications / Q000601:surgery*; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012598:Sclerosis / Q000150:complications / Q000473:pathology; D016896:Treatment Outcome; D055815:Young Adult