title: [Regulatory mechanism underlying pathogen biofilm formation and potential drug targets].
abstract: Bacterial communities usually develop biofilms abound in nature niche. The development of biofilm is a highly dynamic and complex process coordinated by multiple mechanisms, of which two-component system and quorum sensing are two well-defined systems. Biofilm is involved in the virulence of many pathogens. Therefore, targeting the key factors involved in the biofilm formation represents a novel and promising avenue for developing better antibiotics.
authors.affiliation: Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, School ofLife Sciences, Southwest University, Chongqing 400715, China.
authors.forename: Ting-Yu
authors.initials: TY
authors.lastname: Shi
authors.forename: Wan-Yan
authors.initials: WY
authors.lastname: Deng
authors.forename: Jian-Ping
authors.initials: JP
authors.lastname: Xie
mesh_terms: D054742:Acyl-Butyrolactones / Q000378:metabolism*; D001419:Bacteria / Q000235:genetics / Q000378:metabolism*; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D018441:Biofilms / Q000254:growth & development*; D016503:Drug Delivery Systems; D015964:Gene Expression Regulation, Bacterial; D006714:Homoserine / Q000031:analogs & derivatives / Q000378:metabolism; D007783:Lactones / Q000378:metabolism; D053038:Quorum Sensing; D015398:Signal Transduction
chemical_list: D054742:Acyl-Butyrolactones; D001426:Bacterial Proteins; D007783:Lactones; C091088:N-octanoylhomoserine lactone; D006714:Homoserine