title: Long-lasting stress, quantitative changes in nitric oxide concentration and functional state of brain mitochondria.
abstract: We have studied biochemical changes occurring in brain cell mitochondria of white rats on the background of stress induced by 30-day isolation and disruption of circadian rhythms. It was ascertained that due to long-lasting stress, there occurs activation of oxidative processes in mitochondria as well as inhibition of anti-oxidant system activity, causing development of energy deficiency in brain cells. The above-mentioned biochemical processes become the reason for activation and opening of the mitochondrial permeability transition pore (MPTP), which, in its turn, signals the start of neuroapoptosis and various neurodegenerative processes.
authors.affiliation: Department of Biology, Faculty of Exact and Natural Sciences, I. Javakhishvili Tbilisi State University, Tbilii, Georgia. zurabiku@gmail.com.
authors.forename: Zurab
authors.initials: Z
authors.lastname: Kuchukashvili
authors.forename: George
authors.initials: G
authors.lastname: Burjanadze
authors.forename: Ketevan
authors.initials: K
authors.lastname: Menabde
authors.forename: Matrona
authors.initials: M
authors.lastname: Chachua
authors.forename: Natalia
authors.initials: N
authors.lastname: Dachanidze
authors.forename: Mariam
authors.initials: M
authors.lastname: Mikadze
authors.forename: Nana
authors.initials: N
authors.lastname: Koshoridze
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002118:Calcium / Q000494:pharmacology; D002940:Circadian Rhythm / Q000502:physiology; D008297:Male; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D033681:Mitochondrial Membrane Transport Proteins / Q000378:metabolism*; D000083162:Mitochondrial Permeability Transition Pore; D009569:Nitric Oxide / Q000096:biosynthesis / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D015398:Signal Transduction; D013312:Stress, Physiological / Q000502:physiology*
chemical_list: D033681:Mitochondrial Membrane Transport Proteins; D000083162:Mitochondrial Permeability Transition Pore; D009569:Nitric Oxide; D002118:Calcium