title: [Design, synthesis and activities of 4-(2-acetoxybenzoylamino) butyramide derivatives].
abstract: To explore new agents of gamma-aminobutyric acid (GABA) derivatives with more potent antiepileptic activity, a series of 4-(2-acetoxybenzoylamino) butyramide derivatives were designed and synthesized. All of the novel compounds (5a-51) were synthesized from GABA as starting material, and their structures were confirmed with IR, 1H NMR, EI-MS and elemental analysis. Preliminary pharmacological test in vitro showed that all target compounds displayed strong antiepileptic activities and were worth for further study. The structure-activity relationship of 4-(2-acetoxybenzoylamino) butyramide derivatives was also discussed preliminarily.
authors.affiliation: Department of Pharmacology, School of Pharmacy, North Sichuan Medical College, Nanchong 637000, China. lwh790214@163.com
authors.forename: Wen-Hu
authors.initials: WH
authors.lastname: Liu
authors.forename: Shi-Bao
authors.initials: SB
authors.lastname: Wang
authors.forename: Xian
authors.initials: X
authors.lastname: Yu
authors.forename: Xin-Qiang
authors.initials: XQ
authors.lastname: Yin
authors.forename: Yi
authors.initials: Y
authors.lastname: Liu
mesh_terms: D015761:4-Aminopyridine; D000577:Amides / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D004827:Epilepsy / Q000139:chemically induced / Q000188:drug therapy; D005260:Female; D008297:Male; D051379:Mice; D015394:Molecular Structure; D011897:Random Allocation; D013329:Structure-Activity Relationship; D005680:gamma-Aminobutyric Acid / Q000737:chemistry
chemical_list: C582234:4-(2-acetoxybenzoylamino)butyramide; D000577:Amides; D000927:Anticonvulsants; D005680:gamma-Aminobutyric Acid; D015761:4-Aminopyridine