title: Depression and survival in Chinese patients with gastric cancer: a prospective study.
abstract: OBJECTIVE
  Depression is thought to be a predictor of poor survival among cancer patients. In our study, we aimed to investigate the association between depression and survival in patients with gastric cancer.
  
  
  METHODS
  The subjects were a total of 300 patients aged 20-75 years who had histological confirmed diagnosis of gastric cancer from January 2004 to May 2006. Three months after patients diagnosis, depression was scored using by the Depression Status Inventory (DSI) designed by Willian WK Zung. The follow-up period consisted of a total of 13,643 person-months. A Cox's regression analysis was used to assess the association between depression and survival.
  
  
  RESULTS
  The percentage of subjects with depression according to the DSI depression criteria was 31%. Tumor stage and treatment methods were significantly associated with depression of patients. Age (60 years or older), annual income, tumor stage, lymph nodes metastasis and treatment were significantly associated with increased hazard ratio (HR) for gastric cancer survival. The adjusted HR for mortality risk in gastric cancer patients with depression tended to be high (HR=3.34, 95% CI=1.23-5.49) and a significant trend was found (P<0.05).
  
  
  CONCLUSIONS
  The data obtained in this prospective study in Chinese support the hypothesis that depression is associated with poor survival among gastric cancer patients. Further studies with a large sample and longer term follow-up period are needed.
authors.affiliation: Cardiopulmonary Function Room, Third Affiliated Hospital of Harbin Medical University, Harbin, China.
authors.forename: Hui
authors.initials: H
authors.lastname: Yu
authors.forename: Yaoxian
authors.initials: Y
authors.lastname: Wang
authors.forename: Xin
authors.initials: X
authors.lastname: Ge
authors.forename: Xiaoke
authors.initials: X
authors.lastname: Wu
authors.forename: Xiaoqin
authors.initials: X
authors.lastname: Mao
mesh_terms: D000328:Adult; D000368:Aged; D003863:Depression / Q000175:diagnosis* / Q000401:mortality* / Q000523:psychology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D013274:Stomach Neoplasms / Q000401:mortality* / Q000473:pathology / Q000523:psychology*; D015996:Survival Rate; D055815:Young Adult