title: Amyloid and prions: some biochemical investigations of cerebral amyloidosis in mice.
abstract: Prion-like transmission of protein aggregates or amyloid in several neurodegenerative diseases, such as Parkinson's disease, Huntington's disease and Alzheimer's disease, in addition to the transmissible spongiform encephalopathies (or prion diseases), has been proposed recently. This is a controversial idea and, in this paper, we consider what we mean by a "prion", and by "amyloid", and present some biochemical investigations of cerebral prion amyloidosis in mice.
authors.affiliation: Animal Health and Veterinary Laboratory Agency, Pentland Science Park, Bush Loan, Penicuik EH26 0PZ, Midlothian, UK. james.hope@ahvla.gsi.gov.uk
authors.forename: James
authors.initials: J
authors.lastname: Hope
authors.forename: Louise
authors.initials: L
authors.lastname: Kirby
mesh_terms: D000682:Amyloid / Q000378:metabolism*; D000686:Amyloidosis / Q000378:metabolism*; D000818:Animals; D001927:Brain Diseases / Q000378:metabolism* / Q000473:pathology; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D017096:Prion Diseases / Q000378:metabolism* / Q000473:pathology; D011328:Prions / Q000378:metabolism*
chemical_list: D000682:Amyloid; D011328:Prions