title: Focus issue: Adding math to the signaling toolkit.
abstract: This issue of Science Signaling, which complements the 13 April issue of Science, showcases the application of computational approaches to signal transduction research. Research and commentary highlight how mathematical modeling combined with experimental data can yield new insights into how cells interpret, process, and respond to external and internal cues.
authors.forename: Wei
authors.initials: W
authors.lastname: Wong
authors.forename: John F
authors.initials: JF
authors.lastname: Foley
mesh_terms: D019295:Computational Biology; D015398:Signal Transduction / Q000502:physiology*