title: Endothelial function, oxidative stress and inflammatory studies in chronic coronary slow flow phenomenon patients.
abstract: The coronary slow flow phenomenon (CSFP) is associated with coronary microvascular dysfunction although the responsible mechanisms are unknown. This study compared endothelial function assessed by changes in augmentation index (AIx) following endothelium-independent (glyceryl trinitrate, GTN) and endothelium-dependent vasodilators (salbutamol), in 40 stable CSFP patients and 23 age-matched healthy controls. Plasma concentrations of inflammatory proteins (myeloperoxidase and high-sensitivity C-reactive protein), oxidative stress biomarkers (malondialdehyde and homocysteine), and asymmetric dimethylarginine levels were also determined. There were no differences between CSFP and controls in response to salbutamol (AIx: -2.28 ± 0.88% vs. -3.22 ± 0.70%, p = 0.4) or GTN (AIx: -11.30 ± 0.75% vs. -13.30 ± 1.00%, p = 0.12). Similarly, there were no differences in the measured biomarkers. Thus, alternate mechanisms to the assessed endothelial function, inflammatory and oxidative stress processes should be explored to explain the microvascular dysfunction in CSFP patients.
authors.affiliation: Cardiology Unit, Discipline of Medicine, The Queen Elizabeth Hospital, The University of Adelaide, Adelaide, S.A., Australia.
authors.forename: Victoria
authors.initials: V
authors.lastname: Kopetz
authors.forename: Jennifer
authors.initials: J
authors.lastname: Kennedy
authors.forename: Tamila
authors.initials: T
authors.lastname: Heresztyn
authors.forename: Irene
authors.initials: I
authors.lastname: Stafford
authors.forename: Scott R
authors.initials: SR
authors.lastname: Willoughby
authors.forename: John F
authors.initials: JF
authors.lastname: Beltrame
mesh_terms: D058666:Adrenergic beta-2 Receptor Agonists / Q000627:therapeutic use; D000368:Aged; D000420:Albuterol / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D003327:Coronary Disease / Q000188:drug therapy / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008833:Microcirculation / Q000502:physiology; D008875:Middle Aged; D005996:Nitroglycerin / Q000627:therapeutic use; D054318:No-Reflow Phenomenon / Q000188:drug therapy / Q000503:physiopathology*; D018384:Oxidative Stress / Q000502:physiology*; D011446:Prospective Studies; D014665:Vasodilator Agents / Q000627:therapeutic use
chemical_list: D058666:Adrenergic beta-2 Receptor Agonists; D015415:Biomarkers; D014665:Vasodilator Agents; D005996:Nitroglycerin; D000420:Albuterol