title: Genetic diversity of Streptococcus equi subsp. zooepidemicus and doxycycline resistance in kennelled dogs.
abstract: The genetic diversity and antibiotic resistance profiles of 38 Streptococcus equi subsp. zooepidemicus isolates were determined from a kennelled canine population during two outbreaks of hemorrhagic pneumonia (1999 to 2002 and 2007 to 2010). Analysis of the szp gene hypervariable region and the 16S-23S rRNA intergenic spacer region and multilocus sequence typing (MLST) indicated a predominant tetO-positive, doxycycline-resistant ST-10 strain during 1999 to 2002 and a predominant tetM-positive doxycycline-resistant ST-62 strain during 2007 to 2010.
authors.affiliation: The Royal Veterinary College, Department of Pathology and Infectious Diseases, Hatfield, United Kingdom.
authors.forename: Victoria J
authors.initials: VJ
authors.lastname: Chalker
authors.forename: Andrew
authors.initials: A
authors.lastname: Waller
authors.forename: Katy
authors.initials: K
authors.lastname: Webb
authors.forename: Emma
authors.initials: E
authors.lastname: Spearing
authors.forename: Patricia
authors.initials: P
authors.lastname: Crosse
authors.forename: Joe
authors.initials: J
authors.lastname: Brownlie
authors.forename: Kerstin
authors.initials: K
authors.lastname: Erles
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000942:Antigens, Bacterial / Q000235:genetics; D001426:Bacterial Proteins / Q000235:genetics; D021903:DNA, Ribosomal Spacer / Q000235:genetics; D004196:Disease Outbreaks; D004283:Dog Diseases / Q000453:epidemiology / Q000382:microbiology*; D004285:Dogs; D004318:Doxycycline / Q000494:pharmacology*; D024881:Drug Resistance, Bacterial; D014644:Genetic Variation; D008826:Microbial Sensitivity Tests; D058885:Multilocus Sequence Typing; D018410:Pneumonia, Bacterial / Q000453:epidemiology / Q000382:microbiology / Q000662:veterinary*; D013290:Streptococcal Infections / Q000453:epidemiology / Q000382:microbiology / Q000662:veterinary*; D018502:Streptococcus equi / Q000145:classification / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D021903:DNA, Ribosomal Spacer; C107892:SzPSe protein, Streptococcus equi; D004318:Doxycycline