title: Rightward convexity of the great vessel arising from the anterior ventricle: a novel fetal marker for transposition of the great arteries.
abstract: OBJECTIVE
  Traditionally transposition of the great arteries (TGA) is suggested by bifurcation of the great vessel arising from the posterior ventricle and the parallel course of the great vessels as they leave the heart. These findings may be difficult to demonstrate, requiring additional fetal echocardiographic features to indicate TGA. In this study, we investigated a new marker of TGA, namely rightward convexity of the great vessel arising from the anterior ventricle.
  
  
  METHODS
  We reviewed fetal studies from 2006 to 2010 in which an antenatal diagnosis of TGA was confirmed postnatally. We specifically viewed images obtained by scanning the great vessel arising from the anterior ventricle cranially to the superior mediastinum at the level of the three vessels and trachea view and compared them with similar views in normal hearts.
  
  
  RESULTS
  In 21 cases of confirmed TGA, the great vessel arising from the anterior ventricle (aorta) coursing cranially demonstrated an abnormal convexity to the right. This was in contrast to convexity to the left or lack of convexity of the great vessel (pulmonary artery) arising from the anterior ventricle in fetuses with a normal heart. In two fetuses rightward vessel convexity from the anterior ventricle was the clue on the initial scan suggesting TGA, which was subsequently confirmed. In addition, only two vessels, the superior vena cava and aorta, were demonstrated in fetuses with TGA, the pulmonary artery and ductus arteriosus lying below (caudal to) the transverse arch.
  
  
  CONCLUSIONS
  Noting the rightward convexity of the great vessel arising from the anterior ventricle may aid in the prenatal diagnosis of TGA. Furthermore, the relative simplicity of this sign may make it valuable in fetal screening for this cardiac defect.
authors.affiliation: Fetal Cardiac Unit, Monash Medical Centre, Clayton, Victoria, Australia. samuel.menahem@southernhealth.org.au
authors.forename: S
authors.initials: S
authors.lastname: Menahem
authors.forename: A
authors.initials: A
authors.lastname: Rotstein
authors.forename: S
authors.initials: S
authors.lastname: Meagher
mesh_terms: D004452:Echocardiography; D005260:Female; D005333:Fetus / Q000002:abnormalities*; D006801:Humans; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D011446:Prospective Studies; D012189:Retrospective Studies; D014188:Transposition of Great Vessels / Q000000981:diagnostic imaging* / Q000473:pathology; D016216:Ultrasonography, Prenatal