title: Voriconazole-induced phototoxicity in children.
abstract: Voriconazole is used in antifungal prophylaxis. We performed a retrospective review of immunocompromised children receiving prophylaxis with voriconazole during major hospital renovation, who developed phototoxic skin reactions. The overall incidence of phototoxic skin reactions was 33%. A voriconazole dose of ≥6 mg/kg of body weight per dose twice daily was associated with a significantly greater risk to develop phototoxic skin reactions compared with lower doses.
authors.affiliation: Department of Paediatrics, University of Bern, Inselspital, Bern, Switzerland.
authors.forename: Sara
authors.initials: S
authors.lastname: Bernhard
authors.forename: Kristin
authors.initials: K
authors.lastname: Kernland Lang
authors.forename: Roland A
authors.initials: RA
authors.lastname: Ammann
authors.forename: Sonja
authors.initials: S
authors.lastname: Lüer
authors.forename: Kurt
authors.initials: K
authors.lastname: Leibundgut
authors.forename: Miriam
authors.initials: M
authors.lastname: Diepold
authors.forename: Christoph
authors.initials: C
authors.lastname: Aebi
mesh_terms: D018890:Chemoprevention / Q000009:adverse effects* / Q000379:methods*; D002648:Child; D002675:Child, Preschool; D017484:Dermatitis, Phototoxic / Q000453:epidemiology*; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D015994:Incidence; D007223:Infant; D008297:Male; D009181:Mycoses / Q000517:prevention & control; D009369:Neoplasms / Q000150:complications / Q000188:drug therapy; D011743:Pyrimidines / Q000008:administration & dosage* / Q000009:adverse effects*; D012189:Retrospective Studies; D018570:Risk Assessment; D014230:Triazoles / Q000008:administration & dosage* / Q000009:adverse effects*; D065819:Voriconazole
chemical_list: D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole