title: Moderate dietary weight loss reduces myocardial steatosis in obese and overweight women.
abstract: BACKGROUND
  Excessive myocardial triglyceride (MTG) content in obesity and type 2 diabetes is associated with impaired cardiac function. Previous studies suggest that MTG could be mobilized through lifestyle interventions. We assessed influences of moderate dietary weight loss in non diabetic obese and overweight women on MTG content and cardiac function.
  
  
  METHODS
  We selected a subgroup of 38 women from the B-SMART study population. The B-SMART study compared weight loss and associated metabolic and cardiovascular markers with reduced-carbohydrate and reduced-fat hypocaloric diets. Selected subjects had completed a cardiac magnetic resonance (MR) scan including imaging and proton spectroscopy to assess cardiac structure and function as well as MTG content.
  
  
  RESULTS
  An average weight reduction of 5.4 ± 4.3 kg at six months was associated with a relative decrease of MTG of 25% (from 0.72 ± 0.29% at baseline to 0.54 ± 0.23% at follow-up, p<0.001). The response was similar with carbohydrate and fat restriction. Diastolic function expressed as ratio of peak filling rate in E- and A-Phase (PFRE/PFRA) was unchanged. Reductions of left atrial size (from 21.9 ± 4.0 cm(2) to 20.0 ± 3.7 cm(2), p=0.002), the normalized ratio of PFRE and early diastolic lengthening velocity PLV (from 8.2 ± 2.6 to 7.5 ± 2.5, p<0.001) and fat free mass (from 55.1 ± 6.9 kg to 52.7 ± 6.5 kg, p=0.007) reflected altered cardiac volume loading after diet, but did not correlate to MTG content.
  
  
  CONCLUSIONS
  Moderate dietary weight loss significantly reduced MTG content in women with uncomplicated overweight or obesity. Macronutrient composition of the diet did not significantly affect the extent of MTG reduction.
authors.affiliation: Working Group Cardiac MR, Medical Faculty of the Charité Campus Buch and HELIOS Klinikum Berlin Buch, Berlin, Germany. wolfgang.utz@charite.de
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Utz
authors.forename: Stefan
authors.initials: S
authors.lastname: Engeli
authors.forename: Sven
authors.initials: S
authors.lastname: Haufe
authors.forename: Petra
authors.initials: P
authors.lastname: Kast
authors.forename: Jana
authors.initials: J
authors.lastname: Böhnke
authors.forename: Verena
authors.initials: V
authors.lastname: Haas
authors.forename: Mario
authors.initials: M
authors.lastname: Hermsdorf
authors.forename: Susanne
authors.initials: S
authors.lastname: Wiesner
authors.forename: Martin
authors.initials: M
authors.lastname: Pofahl
authors.forename: Julius
authors.initials: J
authors.lastname: Traber
authors.forename: Friedrich C
authors.initials: FC
authors.lastname: Luft
authors.forename: Michael
authors.initials: M
authors.lastname: Boschmann
authors.forename: Jens
authors.initials: J
authors.lastname: Jordan
authors.forename: Jeanette
authors.initials: J
authors.lastname: Schulz-Menger
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism* / Q000473:pathology; D000328:Adult; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism / Q000473:pathology; D050528:Diet, Carbohydrate-Restricted / Q000379:methods / Q000639:trends; D018752:Diet, Fat-Restricted / Q000379:methods / Q000639:trends; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D009765:Obesity / Q000378:metabolism / Q000473:pathology; D050177:Overweight / Q000378:metabolism* / Q000473:pathology; D011446:Prospective Studies; D014280:Triglycerides / Q000378:metabolism*; D015431:Weight Loss / Q000502:physiology*
chemical_list: D014280:Triglycerides