title: Highly efficient (R-X-R)-type carbamates as molecular transporters for cellular delivery.
abstract: The (R-X-R) motif-containing arginine-rich peptides are among the most effective cell-penetrating peptides. The replacement of amide linkages in the (R-X-R) motif by carbamate linkages as in (r-ahx-r)(4) or (r-ahx-r-r-apr-r)(2) increases the efficacy of such oligomers several-fold. Internalization of these oligomers in mammalian cell lines occurs by an energy-independent process. These oligomers show efficient delivery of biologically active plasmid DNA into CHO-K1 cells.
authors.affiliation: Organic Chemistry Division, National Chemical Laboratory, Dr. Homi Bhabha Road, Pune 411 008, India.
authors.forename: Kiran M
authors.initials: KM
authors.lastname: Patil
authors.forename: Rangeetha J
authors.initials: RJ
authors.lastname: Naik
authors.lastname: Rajpal
authors.forename: Moneesha
authors.initials: M
authors.lastname: Fernandes
authors.forename: Munia
authors.initials: M
authors.lastname: Ganguli
authors.forename: Vaijayanti A
authors.initials: VA
authors.lastname: Kumar
mesh_terms: D000818:Animals; D001120:Arginine / Q000737:chemistry* / Q000378:metabolism; D016466:CHO Cells; D002219:Carbamates / Q000737:chemistry* / Q000378:metabolism; D002463:Cell Membrane Permeability; D057846:Cell-Penetrating Peptides / Q000737:chemistry* / Q000378:metabolism; D006224:Cricetinae; D004247:DNA / Q000008:administration & dosage*; D010957:Plasmids / Q000008:administration & dosage*; D014162:Transfection
chemical_list: D002219:Carbamates; D057846:Cell-Penetrating Peptides; D004247:DNA; D001120:Arginine