title: [Relationship and interactions between elevated fasting glucose and hypertension for cardiocerebral vascular disease].
abstract: OBJECTIVE
  To explore the relationship and interaction of elevated fasting glucose and hypertension on cardiocerebral vascular disease.
  
  
  METHODS
  10 054 males and females were recruited for our cross-sectional study during May 2007 to August 2007. Unconditional logistic regression was used to analysis the relationship between fasting glucose and hypertension on cardiocerebral vascular disease. A product of fasting glucose and hypertension was added to the logistic regression model to evaluate the multiplicative interaction and relative excess risk of interaction (RERI), attributable proportion (AP) of interaction and synergy index (S) was applied to evaluate the additive interaction of the two factors. Bootstrap was used to calculate 95% confidence intervals (CI) of RERI, AP and S.
  
  
  RESULTS
  After adjusting age, gender, smoking, drinking, body mass index (BMI) and region, the product of fasting glucose and hypertension was not statistically significant, which means there was no multiplicative interaction between the two. But the additive indexes RERI, AP and S with 95%CI of diabetes and hypertension were 0.64 (0.03, 1.25), 0.27 (0.01, 0.47) and 1.83 (1.02, 5.13) respectively, which means significant additive interaction was shown between the two on cardiovascular disease but not no stroke. And there were no additive interaction between impaired fasting glucose on cardiovascular disease or stroke.
  
  
  CONCLUSIONS
  Hypertension was independently related to cardiovascular disease and stroke in Beijing citizens, and diabetes were independently related to stroke. There was additive interaction between diabetes and hypertension on cardiovascular disease.
authors.affiliation: School of Public Health, Fudan University, Shanghai, China.
authors.forename: Yi-qiang
authors.initials: YQ
authors.lastname: Zhan
authors.forename: Jin-ming
authors.initials: JM
authors.lastname: Yu
authors.forename: Da-yi
authors.initials: DY
authors.lastname: Hu
authors.forename: Yong
authors.initials: Y
authors.lastname: Mao
authors.forename: Rong-jing
authors.initials: RJ
authors.lastname: Ding
authors.forename: Yi-hong
authors.initials: YH
authors.lastname: Sun
authors.forename: Li-jun
authors.initials: LJ
authors.lastname: Zhang
authors.forename: Yuan-yuan
authors.initials: YY
authors.lastname: Fu
authors.forename: She-chang
authors.initials: SC
authors.lastname: Li
authors.forename: Fen
authors.initials: F
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000453:epidemiology; D002561:Cerebrovascular Disorders / Q000453:epidemiology; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000150:complications*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D001786:Blood Glucose