title: Effect of age and maternally-derived antibody status on humoral and cellular immune responses to vaccination of pigs against Erysipelothrix rhusiopathiae.
abstract: The effects of age and maternally-derived antibodies (MDA) on the immune response to Erysipelothrix rhusiopathiae were investigated in piglets orally vaccinated with a live E. rhusiopathiae vaccine at 6, 8 or 10 weeks of age. Seroconversion, determined by ELISA, was evident in MDA positive piglets vaccinated at 8 or 10 weeks of age and in all MDA negative vaccinates. Two weeks after vaccination in the presence of MDA, a T cell response, measured by a lymphocyte proliferation assay, was observed in 25% of piglets vaccinated at 6 weeks of age and in 100% of piglets vaccinated at 8 or 10 weeks of age. The post-vaccinal response to E. rhusiopathiae was more strongly influenced by the maternal antibody status of the piglet at the time of vaccination than the age of the piglet.
authors.affiliation: Department of Swine Diseases, National Veterinary Research Institute, Partyzantów 57, 24-100 Pulawy, Poland. mpomorska@piwet.pulawy.pl
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Pomorska-Mól
authors.forename: Iwona
authors.initials: I
authors.lastname: Markowska-Daniel
authors.forename: Zygmunt
authors.initials: Z
authors.lastname: Pejsak
mesh_terms: D000375:Aging; D000818:Animals; D001428:Bacterial Vaccines / Q000276:immunology*; D004888:Erysipelothrix / Q000276:immunology*; D004889:Erysipelothrix Infections / Q000276:immunology / Q000517:prevention & control*; D007111:Immunity, Cellular; D056724:Immunity, Humoral; D007112:Immunity, Maternally-Acquired / Q000502:physiology*; D013552:Swine; D014611:Vaccination / Q000662:veterinary
chemical_list: D001428:Bacterial Vaccines