title: There's more to flow-mediated dilation than nitric oxide.
abstract: Flow-mediated dilation (FMD) is the standard tool used to assess endothelial function. The premise behind the standard FMD test is that it serves as an endothelial-dependant nitric oxide bioassay; however, the endothelium may release additional dilatory molecules which contribute to FMD, most notably prostacyclin and endothelial-derived hyperpolarizing factor. The relative importance of these molecules to the dilatory response may vary substantially among individuals, particularly in response to a number of diseased states. This review discusses how each of these molecules may contribute to vasodilation, and considers the circumstances in which they may vary.
authors.affiliation: School of Sport and Exercise, Massey University, Wellington, New Zealand. L.Stoner@massey.ac.nz
authors.forename: Lee
authors.initials: L
authors.lastname: Stoner
authors.forename: Melissa Lynn
authors.initials: ML
authors.lastname: Erickson
authors.forename: Joanna Mary
authors.initials: JM
authors.lastname: Young
authors.forename: Simon
authors.initials: S
authors.lastname: Fryer
authors.forename: Manning Joseph
authors.initials: MJ
authors.lastname: Sabatier
authors.forename: James
authors.initials: J
authors.lastname: Faulkner
authors.forename: Danielle Marie
authors.initials: DM
authors.lastname: Lambrick
authors.forename: Kevin Kane
authors.initials: KK
authors.lastname: McCully
mesh_terms: D015415:Biomarkers / Q000378:metabolism*; D004108:Dilatation, Pathologic / Q000175:diagnosis*; D004730:Endothelium, Vascular / Q000473:pathology*; D006801:Humans; D009569:Nitric Oxide / Q000378:metabolism*; D014664:Vasodilation
chemical_list: D015415:Biomarkers; D009569:Nitric Oxide