title: Serum and CSF measles antibody levels increase over time in patients with multiple sclerosis or clinically isolated syndrome.
abstract: In general, measles virus (MV) immunoglobulin G (IgG) antibody titres decline over time. However, we found that serum and CSF MV antibody titres increased with age (slope=0.038, p<0.001 and slope=0.022, p=0.008), respectively, and disease duration (slope=0.031, p=0.002 and slope=0.032, p=0.005), respectively, in patients with multiple sclerosis (MS) or clinically isolated syndrome (CIS). The age dependency of serum antibody levels differed between patients and controls (slope=0.038 versus -0.004, p<0.001). The increasing MV antibody titres over time in MS/CIS patients support a general nonspecific stimulation of B cells and plasma cells that is not confined only to the CNS/CSF compartment.
authors.affiliation: Institute of Neuroscience and Physiology, Department of Neurology, Sahlgrenska University Hospital, Gothenburg, Sweden. cecilia.ahlgren@neuro.gu.se
authors.forename: Cecilia
authors.initials: C
authors.lastname: Ahlgren
authors.forename: Anders
authors.initials: A
authors.lastname: Odén
authors.forename: Tomas
authors.initials: T
authors.lastname: Bergström
authors.forename: Jan
authors.initials: J
authors.lastname: Lycke
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood* / Q000134:cerebrospinal fluid*; D002648:Child; D003711:Demyelinating Diseases / Q000097:blood* / Q000134:cerebrospinal fluid*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008457:Measles / Q000276:immunology*; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood* / Q000134:cerebrospinal fluid*; D013997:Time Factors; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral