title: 14-3-3 zeta as novel molecular target for cancer therapy.
abstract: BACKGROUND
  14-3-3ζ acts as a central hub in signaling networks, which promotes cell proliferation, adhesion and survival and inhibits apoptosis in multiple cancers. Development of inhibitors or agents that interfere with 14-3-3ζ-dependent signaling networks are likely to serve as novel molecular agents for targeted cancer therapy.
  
  
  METHODS
  The role of 14-3-3ζ in cancer and its potential as a novel molecular target for therapy. The involvement of 14-3-3ζ in chemoresistance in multiple cancers provides a rationale for developing novel molecular therapies targeting this protein for more effective cancer management. The keywords used to conduct the literature search for this paper were '14-3-3/14-3-3zeta and cancer', '14-3-3 structure', '14-3-3 inhibitors', '14-3-3 cancer prognosis', '14-3-3 and cancer therapy', 'role/ functions of 14-3-3'.
  
  
  CONCLUSIONS
  14-3-3ζ is a central cellular hub protein regulating multiple signaling pathways involved in cancer development, progression and therapeutic resistance. Thus, 14-3-3ζ may serve as a novel molecular target for cancer therapy. New approaches including synthetic and/or natural inhibitors that interfere with 14-3-3ζ-client interactions need to be developed for effective cancer therapy.
authors.affiliation: York University, Department of Chemistry and Centre for Research in Mass Spectrometry , Toronto, Ontario , Canada.
authors.forename: Ajay
authors.initials: A
authors.lastname: Matta
authors.forename: K W Michael
authors.initials: KW
authors.lastname: Siu
authors.forename: Ranju
authors.initials: R
authors.lastname: Ralhan
mesh_terms: D048948:14-3-3 Proteins / Q000378:metabolism*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis; D049109:Cell Proliferation; D015195:Drug Design; D006801:Humans; D058990:Molecular Targeted Therapy; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D011379:Prognosis; D015398:Signal Transduction / Q000187:drug effects
chemical_list: D048948:14-3-3 Proteins; D000970:Antineoplastic Agents