title: [The clinical value of 3 tesla diffusion-weighted magnetic resonance imaging in the diagnosis of prostate cancer].
abstract: Diffusion-weighted imaging (DWI) is a magnetic resonance imaging (MRI) method and is considered potentially useful for detecting prostate cancer. We evaluated the clinical value of DWI with apparent diffusion coefficient (ADC) maps in addition to T2-weighted imaging (T2WI) using 3 tesla (3 T) MRI. Thirty-three patients with elevated prostate specific antigen were evaluated by MRI with T2WI and DWI prior to transperineal template-guided mapping biopsy. The MRI findings were compared with the pathology of biopsy specimens in six parts of prostate : both sides of outer peripheral zones, inner peripheral zones, and transition zones. The sensitivities, specificities and accuracies were 42.1, 84.4 and 76.3％ in T2WI, 57.1, 84.7 and 80.8% in T2WI/DWI, and 87.5, 85.2 and 85.4% in DWI/ADC using 0.951×10 -3 mm2/s as cutoff ADC value. The hazard ratio of patients whose ADC values were under the cutoff was 25.86 by multivariate analysis. Mean ADC values were significantly different between cancer positive and negative cores (p＜0.001). The ADC value showed a negative correlation with increasing tumor length (p＝0.0047). Although further study with a large number of patients is necessary, DWI/ADC using 3 T MRI is a useful tool for detecting prostate cancer.
authors.affiliation: The Department of Urology, Kochi Medical School, Japan.
authors.forename: Tsutomu
authors.initials: T
authors.lastname: Shimamoto
authors.forename: Shingo
authors.initials: S
authors.lastname: Ashida
authors.forename: Ichiro
authors.initials: I
authors.lastname: Yamasaki
authors.forename: Takahira
authors.initials: T
authors.lastname: Kuno
authors.forename: Hideo
authors.initials: H
authors.lastname: Fukuhara
authors.forename: Satoshi
authors.initials: S
authors.lastname: Fukata
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Satake
authors.forename: Kenji
authors.initials: K
authors.lastname: Tamura
authors.forename: Takashi
authors.initials: T
authors.lastname: Karashima
authors.forename: Masayuki
authors.initials: M
authors.lastname: Kamata
authors.forename: Keiji
authors.initials: K
authors.lastname: Inoue
authors.forename: Taro
authors.initials: T
authors.lastname: Shuin
authors.forename: Shinji
authors.initials: S
authors.lastname: Kariya
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Ogawa
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000473:pathology; D012680:Sensitivity and Specificity