title: Guanacastane-type diterpenoids from Coprinus radians.
abstract: Thirteen diterpenoids, named radianspenes A-M (1-13), including three lactams radianspenes J (10), K (11) and L (12) and one dimer radianspene M (13), were isolated from fermentation products of the higher fungal strain Coprinus radians M65. All these compounds possessing guanacastane skeleton were evaluated for antitumor activity using MDA-MB-435 cell line. Radianspene C exhibited inhibitory activity with IC(50) of 0.91 μM.
authors.affiliation: Key Laboratory of the Ministry of Education for Cell Biology and Tumor Cell Engineering, Xiamen, Fujian 361005, PR China.
authors.forename: Yi-xin
authors.initials: YX
authors.lastname: Ou
authors.forename: Yao-yao
authors.initials: YY
authors.lastname: Li
authors.forename: Xiao-ming
authors.initials: XM
authors.lastname: Qian
authors.forename: Yue-mao
authors.initials: YM
authors.lastname: Shen
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D003302:Coprinus / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry / Q000145:classification / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes