title: Perinatal outcome in cases of latent syphilis during pregnancy.
abstract: OBJECTIVE
  To investigate factors associated with latent syphilis and pregnancy outcome among women with latent syphilis.
  
  
  METHODS
  A retrospective population-based study was conducted to compare all pregnancies among women with and without latent syphilis at Soroka University Medical Center, Be'er-Sheva, Israel, between 1988 and 2010. Stratified analysis using a multiple logistic regression model was performed to control for confounders.
  
  
  RESULTS
  Of the 219656 deliveries during the study period, 159 (0.1%) involved women with latent syphilis. Multivariate analysis with backward elimination revealed the following conditions to be significantly associated with latent syphilis: fetal growth restriction (odds ratio [OR] 2.20; 95% confidence interval [CI], 1.07-4.49; P=0.03); drug abuse (OR 9.95; 95% CI, 1.31-75.46; P=0.02); tobacco use (OR 3.35; 95% CI, 1.74-6.45; P<0.05); and Jewish (vs Bedouin) ethnicity (OR 4.05; 95% CI, 2.65-6.20; P<0.05).
  
  
  CONCLUSIONS
  Women with latent syphilis are at risk for adverse maternal and perinatal outcomes, including fetal growth restriction. Careful surveillance of these high-risk pregnancies should be considered.
authors.affiliation: Joyce and Irving Goldman Medical School, Faculty of Health Sciences, Soroka University Medical Center, Ben Gurion University of the Negev, Be'er-Sheva, Israel.
authors.forename: Yonit
authors.initials: Y
authors.lastname: Krakauer
authors.forename: Gali
authors.initials: G
authors.lastname: Pariente
authors.forename: Ruslan
authors.initials: R
authors.lastname: Sergienko
authors.forename: Arnon
authors.initials: A
authors.lastname: Wiznitzer
authors.forename: Eyal
authors.initials: E
authors.lastname: Sheiner
mesh_terms: D005260:Female; D005317:Fetal Growth Retardation / Q000453:epidemiology / Q000209:etiology*; D006801:Humans; D007557:Israel; D016015:Logistic Models; D015999:Multivariate Analysis; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000382:microbiology*; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D013592:Syphilis, Latent / Q000150:complications* / Q000453:epidemiology