title: Minocycline-induced fulminant intracranial hypertension.
abstract: OBJECTIVE
  To describe the clinical course of an unusually severe case of minocycline-induced intracranial hypertension.
  
  
  METHODS
  Case study.
  
  
  METHODS
  Academic medical center.
  
  
  METHODS
  Twelve-year-old girl with a fulminant course of intracranial hypertension.
  
  
  METHODS
  Magnetic resonance imaging and venography of the brain, lumbar puncture, and optic nerve sheath fenestration.
  
  
  RESULTS
  Although the patient ceased minocycline treatment, there was ongoing and rapid worsening of symptoms and vision loss. Lumbar puncture, which normally acts as a temporizing measure to preserve vision, failed to prevent, and may even have precipitated, further deterioration in vision, necessitating surgical intervention with optic nerve sheath fenestration.
  
  
  CONCLUSIONS
  Minocycline can cause a fulminant syndrome of elevated intracranial pressure, with severe vision loss, even after the medication has been discontinued.
authors.affiliation: Department of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia, USA.
authors.forename: Clare L
authors.initials: CL
authors.lastname: Fraser
authors.forename: Valerie
authors.initials: V
authors.lastname: Biousse
authors.forename: Nancy J
authors.initials: NJ
authors.lastname: Newman
mesh_terms: D002648:Child; D005260:Female; D006801:Humans; D019586:Intracranial Hypertension / Q000139:chemically induced* / Q000150:complications / Q000175:diagnosis*; D008911:Minocycline / Q000009:adverse effects*; D009900:Optic Nerve / Q000473:pathology; D014786:Vision Disorders / Q000139:chemically induced / Q000150:complications / Q000175:diagnosis
chemical_list: D008911:Minocycline