title: In vitro activity of ceftaroline against clinical isolates of Streptococcus pneumoniae recovered in 43 U.S. medical centers during 2010-2011.
abstract: The in vitro activity of ceftaroline, a recently introduced parenteral cephalosporin, was assessed versus 1,750 isolates of Streptococcus pneumoniae recovered from patients with a variety of pneumococcal infections in 43 U.S. medical centers during 2010-2011. Using a breakpoint of ≤ 0.5 μg/ml for susceptibility, all of the isolates were found to be susceptible to ceftaroline. Ceftaroline MICs were consistently 16-fold lower than ceftriaxone MICs. Among the isolates characterized in this investigation, 38.9% were found to be nonsusceptible to penicillin (oral penicillin breakpoints) and 9.1% were nonsusceptible to ceftriaxone (nonmeningitis breakpoints).
authors.affiliation: Department of Pathology, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA. gdoern@nc.rr.com
authors.forename: Gary V
authors.initials: GV
authors.lastname: Doern
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Diekema
authors.forename: Kristopher P
authors.initials: KP
authors.lastname: Heilmann
authors.forename: Cassie L
authors.initials: CL
authors.lastname: Dohrn
authors.forename: Fathollah
authors.initials: F
authors.lastname: Riahi
authors.forename: Sandra S
authors.initials: SS
authors.lastname: Richter
mesh_terms: D002443:Ceftriaxone / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000494:pharmacology; D013296:Streptococcus pneumoniae / Q000187:drug effects*; D000097583:Ceftaroline
chemical_list: D002443:Ceftriaxone; D002511:Cephalosporins; D010406:Penicillins; D000097583:Ceftaroline