title: Hypoxia-inducible factor-1alpha: molecular-targeted therapy for hepatocellular carcinoma.
abstract: Hypoxia-inducible factor (HIF)-1α is over-expressed in hepatocellular carcinoma (HCC) and degraded by ubiquitin-proteasome pathways under normoxic conditions. Hepatocyte hypoxia enhances proliferation, angiogenesis, metastasis, chemoresistance, and radioresistance of HCC. The importance role of HIF-1α expression in HCC may improve the prognostic and therapeutic technique. This article reviews the HIF-1α expression and its gene during the rat HCC development, the level of HIF-1α expression in HCC patients, and the effect of silencing HIF-1α gene by miRNA on inhibition of HepG2 cell proliferation.
authors.affiliation: Department of Diagnostics, Affiliated Hospital of Nantong University, Nantong 226001 Jiangsu Province, China.
authors.forename: Z Z
authors.initials: ZZ
authors.lastname: Dong
authors.forename: M
authors.initials: M
authors.lastname: Yao
authors.forename: L
authors.initials: L
authors.lastname: Wang
authors.forename: W
authors.initials: W
authors.lastname: Wu
authors.forename: X
authors.initials: X
authors.lastname: Gu
authors.forename: D F
authors.initials: DF
authors.lastname: Yao
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000628:therapy*; D020868:Gene Silencing; D006801:Humans; D051795:Hypoxia-Inducible Factor 1, alpha Subunit / Q000235:genetics / Q000502:physiology*; D008113:Liver Neoplasms / Q000628:therapy*; D035683:MicroRNAs / Q000235:genetics; D058990:Molecular Targeted Therapy
chemical_list: C497442:HIF1A protein, human; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D035683:MicroRNAs