title: Oxidative stress in children with attention deficit hyperactivity disorder.
abstract: OBJECTIVE
  The aim of this study was to investigate oxidative stress in ADHD children.
  
  
  METHODS
  Levels of oxidant parameters malondialdehyde (MDA), 8-hydroxy-2'-deoxyguanosine (8-OHDG), advanced oxidation protein products (AOPP) and antioxidant parameters paraoxonase (PON1) and thiol levels were measured in thirty children with ADHD (27 boys, 3 girls) who were firstly diagnosed according to DSM-IV and thirty healthy children (18 boys, 12 girls) aged 6-12 years.
  
  
  RESULTS
  The levels of the oxidant parameters MDA and 8-OHDG were statistically significantly lower in ADHD children compared to the controls. We did not find a significant difference between the groups regarding AOPP, PON1, and thiol levels.
  
  
  CONCLUSIONS
  We found low levels of some oxidants and no difference of antioxidant parameters in ADHD children. Our study points out that there may not be a direct relationship between oxidative stress and ADHD.
authors.affiliation: Department of Child Psychiatry, Erciyes University School of Medicine, Kayseri, Turkey. dboztop@hotmail.com
authors.forename: Didem
authors.initials: D
authors.lastname: Oztop
authors.forename: Hatice
authors.initials: H
authors.lastname: Altun
authors.forename: Gülden
authors.initials: G
authors.lastname: Baskol
authors.forename: Saliha
authors.initials: S
authors.lastname: Ozsoy
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D043303:Aryldialkylphosphatase / Q000378:metabolism; D001289:Attention Deficit Disorder with Hyperactivity / Q000175:diagnosis / Q000378:metabolism*; D001798:Blood Proteins / Q000378:metabolism; D002648:Child; D002851:Chromatography, High Pressure Liquid; D003849:Deoxyguanosine / Q000031:analogs & derivatives* / Q000378:metabolism; D039721:Diagnostic and Statistical Manual of Mental Disorders; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism*; D018384:Oxidative Stress; D013438:Sulfhydryl Compounds / Q000378:metabolism; D011795:Surveys and Questionnaires
chemical_list: D001798:Blood Proteins; D013438:Sulfhydryl Compounds; D008315:Malondialdehyde; D000080242:8-Hydroxy-2'-Deoxyguanosine; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human; D003849:Deoxyguanosine