title: Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles.
abstract: Continuing efforts to discover novel means of combating fluconazole resistance in Candida albicans have identified an indole derivative that sensitizes strains demonstrating resistance to fluconazole. This tetracycle (3, ML229) does not appear to act through established Hsp90 or calcineurin pathways to chemosensitize C. albicans, as determined in Saccharomyces cerevisiae models, and may be a useful probe to uncover alternative resistance pathways.
authors.affiliation: Chemical Biology Platform and Probe Development Center, Broad Institute of MIT and Harvard, 7 Cambridge Center, Cambridge, MA 02142, USA.
authors.forename: Willmen
authors.initials: W
authors.lastname: Youngsaye
authors.forename: Chris
authors.initials: C
authors.lastname: Dockendorff
authors.forename: Benjamin
authors.initials: B
authors.lastname: Vincent
authors.forename: Cathy L
authors.initials: CL
authors.lastname: Hartland
authors.forename: Joshua A
authors.initials: JA
authors.lastname: Bittker
authors.forename: Sivaraman
authors.initials: S
authors.lastname: Dandapani
authors.forename: Michelle
authors.initials: M
authors.lastname: Palmer
authors.forename: Luke
authors.initials: L
authors.lastname: Whitesell
authors.forename: Susan
authors.initials: S
authors.lastname: Lindquist
authors.forename: Stuart L
authors.initials: SL
authors.lastname: Schreiber
authors.forename: Benito
authors.initials: B
authors.lastname: Munoz
mesh_terms: D002176:Candida albicans / Q000187:drug effects*; D025141:Drug Resistance, Fungal / Q000187:drug effects*; D015725:Fluconazole / Q000494:pharmacology*; D007211:Indoles / Q000737:chemistry* / Q000494:pharmacology*; D015398:Signal Transduction
chemical_list: D007211:Indoles; D015725:Fluconazole