title: Magnetic resonance lymphography findings in patients with biochemical recurrence after prostatectomy and the relation with the Stephenson nomogram.
abstract: OBJECTIVE
  To estimate the occurrence of positive lymph nodes on magnetic resonance lymphography (MRL) in patients with a prostate-specific antigen (PSA) recurrence after prostatectomy and to investigate the relation between score on the Stephenson nomogram and lymph node involvement on MRL.
  
  
  METHODS
  Sixty-five candidates for salvage radiation therapy were referred for an MRL to determine their lymph node status. Clinical and histopathologic features were recorded. For 49 patients, data were complete to calculate the Stephenson nomogram score. Receiver operating characteristic (ROC) analysis was performed to determine how well this nomogram related to the MRL result. Analysis was done for the whole group and separately for patients with a PSA <1.0 ng/mL to determine the situation in candidates for early salvage radiation therapy, and for patients without pathologic lymph nodes at initial lymph node dissection.
  
  
  RESULTS
  MRL detected positive lymph nodes in 47 patients. ROC analysis for the Stephenson nomogram yielded an area under the curve (AUC) of 0.78 (95% confidence interval, 0.61-0.93). Of 29 patients with a PSA <1.0 ng/mL, 18 had a positive MRL. Of 37 patients without lymph node involvement at initial lymph node dissection, 25 had a positive MRL. ROC analysis for the Stephenson nomogram showed AUCs of 0.84 and 0.74, respectively, for these latter groups.
  
  
  CONCLUSIONS
  MRL detected positive lymph nodes in 72% of candidates for salvage radiation therapy, in 62% of candidates for early salvage radiation therapy, and in 68% of initially node-negative patients. The Stephenson nomogram showed a good correlation with the MRL result and may thus be useful for identifying patients with a PSA recurrence who are at high risk for lymph node involvement.
authors.affiliation: Department of Radiation Oncology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands. H.Meijer@rther.umcn.nl
authors.forename: Hanneke J M
authors.initials: HJ
authors.lastname: Meijer
authors.forename: Oscar A
authors.initials: OA
authors.lastname: Debats
authors.forename: Mack
authors.initials: M
authors.lastname: Roach
authors.forename: Paul N
authors.initials: PN
authors.lastname: Span
authors.forename: J Alfred
authors.initials: JA
authors.lastname: Witjes
authors.forename: Johannes H A M
authors.initials: JH
authors.lastname: Kaanders
authors.forename: Emile N J Th
authors.initials: EN
authors.lastname: van Lin
authors.forename: Jelle O
authors.initials: JO
authors.lastname: Barentsz
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D016001:Confidence Intervals; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology; D015182:Lymphatic Irradiation; D008207:Lymphatic Metastasis; D008220:Lymphography / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading / Q000379:methods; D009364:Neoplasm Recurrence, Local / Q000097:blood / Q000532:radiotherapy; D049451:Nomograms; D017430:Prostate-Specific Antigen / Q000097:blood*; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000097:blood / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D012372:ROC Curve; D012189:Retrospective Studies; D016879:Salvage Therapy / Q000379:methods
chemical_list: D017430:Prostate-Specific Antigen