title: [Association of radiotherapy and hormonotherapy in locally advanced prostate cancer].
abstract: Combination of radiotherapy and androgen deprivation is now considered as the standard of care for patients with a localized prostate cancer but poor prognostic factors. Two groups of randomized trials have led to this recommendation. Some have compared radiotherapy alone versus hormonal treatment and radiotherapy: these trials demonstrated, now with a long follow-up, an improvement in 10-year survival for the combined treatment. Three recent trials compared androgen deprivation alone or combined with radiotherapy; a benefit in survival was also demonstrated in favour of the combination. Some questions remained concerning the optimal duration of hormonal treatment, in view of its potential side effects. Patients in the intermediate prognostic groups could receive a short-term androgen deprivation, but those with a high Gleason score must be treated with a long-term hormonal treatment. Modalities of radiotherapy, regarding volumes and dose must also be precised in the next years.
authors.affiliation: Hôpital Saint-Louis, service de cancérologie-radiothérapie, 1, avenue Claude-Vellefaux, 75475 Paris, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Quero
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Wong-Hee-Kam
authors.forename: Sofia
authors.initials: S
authors.lastname: Rivera
authors.forename: Christophe
authors.initials: C
authors.lastname: Hennequin
mesh_terms: D000726:Androgen Antagonists / Q000009:adverse effects / Q000627:therapeutic use*; D001851:Bone Diseases, Metabolic / Q000139:chemically induced; D003131:Combined Modality Therapy / Q000379:methods; D006801:Humans; D008297:Male; D060787:Neoplasm Grading; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D016032:Randomized Controlled Trials as Topic; D018570:Risk Assessment; D013997:Time Factors
chemical_list: D000726:Androgen Antagonists