title: Asymmetric bioreduction of activated alkenes to industrially relevant optically active compounds.
abstract: Ene-reductases from the 'Old Yellow Enzyme' family of flavoproteins catalyze the asymmetric reduction of various α,β-unsaturated compounds at the expense of a nicotinamide cofactor. They have been applied to the synthesis of valuable enantiopure products, including chiral building blocks with broad industrial applications, terpenoids, amino acid derivatives and fragrances. The combination of these highly stereoselective biocatalysts with a cofactor recycling system has allowed the development of cost-effective methods for the generation of optically active molecules, which is strengthened by the availability of stereo-complementary enzyme homologues.
authors.affiliation: Department of Chemistry, Organic & Bioorganic Chemistry, University of Graz, Heinrichstrasse 28, 8010 Graz, Austria.
authors.forename: Christoph K
authors.initials: CK
authors.lastname: Winkler
authors.forename: Gábor
authors.initials: G
authors.lastname: Tasnádi
authors.forename: Dorina
authors.initials: D
authors.lastname: Clay
authors.forename: Mélanie
authors.initials: M
authors.lastname: Hall
authors.forename: Kurt
authors.initials: K
authors.lastname: Faber
mesh_terms: D000475:Alkenes / Q000737:chemistry* / Q000378:metabolism*; D000596:Amino Acids / Q000378:metabolism; D055162:Biocatalysis; D001709:Biotechnology / Q000379:methods*; D009252:NADPH Dehydrogenase / Q000378:metabolism*; D009570:Nitriles / Q000737:chemistry; D010476:Perfume / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism; D013729:Terpenes / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: D000475:Alkenes; D000596:Amino Acids; D009570:Nitriles; D010476:Perfume; D013729:Terpenes; D009252:NADPH Dehydrogenase