title: [A case report of undifferentiated connective tissue disease associated myelodysplastic].
abstract: A 58-year-old man exhibited polyarthritis, fever, thrombocytopenia and progressive anemia. Undifferentiated connective tissue diseases(UCTD) was  diagnosed based on laboratory and radiographic findings. After diagnosis, the patient received glucocorticoid and blood-transfusion. The symptoms  were improved notablely. However,the level of hemoglobin was lower than normal(between 57 g/L and 75 g/L). Thrombocytes were 19 000/microl to 32  000/microl. Bone marrow aspiration revealed highly abnormal cell morphology, indicating myelodysplastic syndrome(MDS). A diagnosis of UCTD with  MDS was made. The patient was successfully treated by decitabine and thalidomide(an immunosuppressive regimen). It is necessary to promptly  examine bone marrow cell morphology and chromosomal aberration in cases with connective tissue diseases complicated by sudden cytopenia and  thrombocytopenia.
authors.affiliation: Department of Rheumatology and Immunology, The Second Hospital of Shanxi Medical University, Taiyuan 030001, China.
authors.forename: Xiao-ying
authors.initials: XY
authors.lastname: Zhang
authors.forename: Hong-yan
authors.initials: HY
authors.lastname: Wen
authors.forename: Jun-wei
authors.initials: JW
authors.lastname: Chen
authors.forename: Xiao-feng
authors.initials: XF
authors.lastname: Li
authors.forename: Li-xing
authors.initials: LX
authors.lastname: Wang
mesh_terms: D001374:Azacitidine / Q000031:analogs & derivatives / Q000627:therapeutic use; D003240:Connective Tissue Diseases / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D000077209:Decitabine; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D013792:Thalidomide / Q000627:therapeutic use
chemical_list: D007166:Immunosuppressive Agents; D013792:Thalidomide; D000077209:Decitabine; D001374:Azacitidine