title: Chemokine receptor CXCR3 is involved in the acute pancreatitis-associated lung injury.
abstract: Acute pancreatitis is a common disease, which is divided into mild pancreatitis and severe pancreatitis. For the latter, a systemic inflammatory response may occur and lead to distant organ damage and the development of multiple organ dysfunction syndrome (MODS), which accounts for significant morbidity and mortality in humans. Chemokines and their receptors are being believed to play a pivotal role in the pathogenesis of acute pancreatitis. Chemokine receptor CXCR3 is reported to be involved in acute tissue injury, for example acute lung injury induced by cigarette smoking, but its role in acute pancreatitis is not yet known. In this study, two animal models of acute pancreatitis (cerulein- and arginine-induced pancreatitis) were applied in CXCR3⁻/⁻ mice and wild-type mice, in order to explore the role of CXCR3 in acute pancreatitis. Serum amylase, lipase and histological observations revealed that CXCR3 knockout did not affect the severity of acute pancreatitis. However, edema and inflammatory cell infiltrate in the lung tissue were attenuated in CXCR3⁻/⁻ mice when acute pancreatitis was induced. In conclusion, chemokine receptor CXCR3 is not involved in acute pancreatic injury, but has a connection with acute pancreatitis-associated lung injury. Acute pulmonary injury is attenuated in CXCR3 knockout mice in experimental acute pancreatitis.
authors.affiliation: Department of Gastroenterology, Shanghai First People's Hospital, Shanghai Jiaotong University School of Medicine, 301 Haining Road, Hongkou District, Shanghai 200080, China.
authors.forename: Jiaqing
authors.initials: J
authors.lastname: Shen
authors.forename: Rong
authors.initials: R
authors.lastname: Wan
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Shen
authors.forename: Jing
authors.initials: J
authors.lastname: Gao
authors.forename: Xia
authors.initials: X
authors.lastname: Wang
authors.forename: Lan
authors.initials: L
authors.lastname: Qian
authors.forename: Huili
authors.initials: H
authors.lastname: Lu
authors.forename: Wei
authors.initials: W
authors.lastname: Han
authors.forename: Xingpeng
authors.initials: X
authors.lastname: Wang
mesh_terms: D000208:Acute Disease; D055371:Acute Lung Injury / Q000209:etiology / Q000503:physiopathology*; D000681:Amylases / Q000097:blood; D000818:Animals; D001120:Arginine / Q000633:toxicity; D002108:Ceruletide / Q000633:toxicity; D004195:Disease Models, Animal; D008049:Lipase / Q000097:blood; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D010195:Pancreatitis / Q000150:complications* / Q000503:physiopathology; D054367:Receptors, CXCR3 / Q000235:genetics*; D012720:Severity of Illness Index
chemical_list: C515188:Cxcr3 protein, mouse; D054367:Receptors, CXCR3; D002108:Ceruletide; D001120:Arginine; D008049:Lipase; D000681:Amylases