title: Association of the adiponectin gene (ADIPOQ) +45 T > G polymorphism with the metabolic syndrome among Han Chinese in Sichuan province of China.
abstract: The metabolic syndrome is a cluster of abnormalities characterized by obesity, impaired glucose metabolism, hypertension or elevated blood pressure, and dyslipidemia. The aim of this study was to investigate the association of the adiponectin gene (ADIPOQ) +45 T > G polymorphism with the metabolic syndrome among Han Chinese in Sichuan province of China. A case-control design was used including 116 patients with the metabolic syndrome and 108 unrelated controls, matched on age and gender. The ADIPOQ +45G allele (TG+GG) had a significant association with risk of the metabolic syndrome (odds ratio=1.88, 95% confidence interval: 1.03-3.44, p=0.039) adjusted for education, physical activity, family history of related diseases, smoking and drinking, compared with subjects with TT genotype. The association between the ADIPOQ +45 T>G polymorphism and the metabolic syndrome was independent of multiple confounders.
authors.affiliation: Department of Epidemiology and Health Statistics, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing, China.
authors.forename: Xiaotong
authors.initials: X
authors.lastname: Li
authors.forename: Daying
authors.initials: D
authors.lastname: Wei
authors.forename: Huijing
authors.initials: H
authors.lastname: He
authors.forename: Jianhua
authors.initials: J
authors.lastname: Zhang
authors.forename: Chunxiu
authors.initials: C
authors.lastname: Wang
authors.forename: Mingju
authors.initials: M
authors.lastname: Ma
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.forename: Tao
authors.initials: T
authors.lastname: Yu
authors.forename: Li
authors.initials: L
authors.lastname: Pan
authors.forename: Fang
authors.initials: F
authors.lastname: Xue
authors.forename: Haiqing
authors.initials: H
authors.lastname: He
authors.forename: Weiwei
authors.initials: W
authors.lastname: Xu
authors.forename: Tingfang
authors.initials: T
authors.lastname: Pan
authors.forename: Qian
authors.initials: Q
authors.lastname: Zuo
authors.forename: Lindblad
authors.initials: L
authors.lastname: Ulf
authors.forename: Guangliang
authors.initials: G
authors.lastname: Shan
mesh_terms: D052242:Adiponectin / Q000235:genetics* / Q000378:metabolism; D000328:Adult; D000483:Alleles; D054458:Amplified Fragment Length Polymorphism Analysis; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D002681:China; D003430:Cross-Sectional Studies; D005260:Female; D056726:Genetic Association Studies; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood / Q000208:ethnology / Q000235:genetics* / Q000378:metabolism; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D011795:Surveys and Questionnaires
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin