title: Use of non-benzodiazepine hypnotics is associated with decreased risk of coronary artery disease.
abstract: BACKGROUND
  It has been reported that the use of benzodiazepines (BDZs) is associated with an increased risk of coronary artery disease (CAD). However, it is still unclear whether or not non-BDZs use has the same adverse effect on the cardiovascular system.
  
  
  METHODS
  We conducted a hospital-based case-control study with 864 CAD patients and 1,008 controls to explore the association between non-BDZs use and CAD risk in Chinese Han population.
  
  
  RESULTS
  Non-BDZs use was found to be associated with a decreased risk of CAD (adjusted odds ratio, OR=0.73; 95% confidence interval, CI=0.54-0.98). Adjusted ORs were 0.91 (95% CI=0.63-1.32) for using non-BDZs 0 to 5 years, 0.64 (95% CI=0.38-0.97) for 5 to 10 years, and 0.42 (95% CI=0.18-0.85) for >10 years. The risk of CAD tended to decrease with an increase in duration of non-BDZs use (p<0.001 for trend).
  
  
  CONCLUSIONS
  Our study demonstrates that non-BDZs use is associated with a decreased risk of CAD. The potential cardiovascular protective mechanisms of non-BDZs should be investigated further.
authors.affiliation: Department of Cardiology, The Second Affiliated Hospital of Soochow University, China.
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhou
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jianchang
authors.initials: J
authors.lastname: Chen
authors.forename: Weiting
authors.initials: W
authors.lastname: Xu
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People / Q000208:ethnology*; D001569:Benzodiazepines; D002316:Cardiotonic Agents / Q000008:administration & dosage*; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000208:ethnology* / Q000517:prevention & control*; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D002316:Cardiotonic Agents; D006993:Hypnotics and Sedatives; D001569:Benzodiazepines