title: Opportunistic pathogens in diabetic foot lesions.
abstract: Accurate identification of infection in diabetic foot lesions is essential as the alternative can result in complicated medical and/or surgical interventions. The aim should be the differentiation between colonization and infection to avoid premature initiation of antimicrobial therapy. Diabetic foot ulcers provide a suitable environment for a diversity of microorganisms to first contaminate then subsequently colonize the wound. Infection can occur when a pathogenic factor produced by one or more microorganisms exceeds the capacity of the host immune system causing tissue damage and triggering both local and systemic inflammatory responses. The progression from wound colonization to infection is influenced by various factors including type and depth of the wound, blood supply, immune status of the patient. The quantity of microbial flora and pathogenicity expressed by the microorganisms involved will also have an effect.
authors.affiliation: University of Manchester, Manchester Diabetes Centre, 193 Hathersage Road, Manchester M13 0JE, UK. frank.bowling@manchester.ac.uk
authors.forename: Frank L
authors.initials: FL
authors.lastname: Bowling
authors.forename: Sanjay U
authors.initials: SU
authors.lastname: Dissanayake
authors.forename: Edward B
authors.initials: EB
authors.lastname: Jude
mesh_terms: D000671:Amputation, Surgical; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D003646:Debridement; D017719:Diabetic Foot / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D009894:Opportunistic Infections / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology*; D012720:Severity of Illness Index; D013290:Streptococcal Infections / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology*; D013291:Streptococcus / Q000472:pathogenicity*; D014946:Wound Infection / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents