title: Hybrid semiconducting polymer dot-quantum dot with narrow-band emission, near-infrared fluorescence, and high brightness.
abstract: This communication describes a new class of semiconducting polymer nanoparticle-quantum dot hybrid with high brightness, narrow emission, near-IR fluorescence, and excellent cellular targeting capability. Using this approach, we circumvented the current difficulty with obtaining narrow-band-emitting and near-IR-fluorescing semiconducting polymer nanoparticles while combining the advantages of both semiconducting polymer nanoparticles and quantum dots. We further demonstrated the use of this new class of hybrid nanomaterial for effective and specific cellular and subcellular labeling without any noticeable nonspecific binding. This hybrid nanomaterial is anticipated to find use in a variety of in vitro and in vivo biological applications.
authors.affiliation: Department of Chemistry, University of Washington, Seattle, Washington 98195, USA.
authors.forename: Yang-Hsiang
authors.initials: YH
authors.lastname: Chan
authors.forename: Fangmao
authors.initials: F
authors.lastname: Ye
authors.forename: Maria Elena
authors.initials: ME
authors.lastname: Gallina
authors.forename: Xuanjun
authors.initials: X
authors.lastname: Zhang
authors.forename: Yuhui
authors.initials: Y
authors.lastname: Jin
authors.forename: I-Che
authors.initials: IC
authors.lastname: Wu
authors.forename: Daniel T
authors.initials: DT
authors.lastname: Chiu
mesh_terms: D005453:Fluorescence; D005456:Fluorescent Dyes / Q000032:analysis* / Q000737:chemistry; D006367:HeLa Cells; D006801:Humans; D018613:Microscopy, Confocal; D053758:Nanoparticles / Q000032:analysis* / Q000737:chemistry / Q000648:ultrastructure; D011108:Polymers / Q000737:chemistry*; D045663:Quantum Dots; D012666:Semiconductors
chemical_list: D005456:Fluorescent Dyes; D011108:Polymers