title: Isopentenyl diphosphate isomerase: A checkpoint to isoprenoid biosynthesis.
abstract: Even if the isopentenyl diphosphate (IPP) isomerases have been discovered in the 50s, it is only in the last decade that the genetical, enzymatical, structural richness and cellular importance of this large family of crucial enzymes has been uncovered. Present in all living kingdoms, they can be classified in two subfamilies: type 1 and type 2 IPP isomerases, which show clearly distinct characteristics. They all perform the regulatory isomerization of isopentenyl diphosphate into dimethylallyl diphosphate, a key rate-limiting step of the terpenoid biosynthesis, via a protonation/deprotonation mechanism. Due to their importance in the isoprenoid metabolism and the increasing interest of industry devoted to terpenoid production, it is foreseen that the biotechnological development of such enzymes should be under intense scrutiny in the near future.
authors.affiliation: Laboratoire de Chimie des Polymères Organiques - CNRS, UMR 5629, ENSCBP - IPB, 16 avenue Pey-Berland, 33607 Pessac cedex, France. kberthelot@enscbp.fr
authors.forename: Karine
authors.initials: K
authors.lastname: Berthelot
authors.forename: Yannick
authors.initials: Y
authors.lastname: Estevez
authors.forename: Alain
authors.initials: A
authors.lastname: Deffieux
authors.forename: Frédéric
authors.initials: F
authors.lastname: Peruch
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D019748:Carbon-Carbon Double Bond Isomerases / Q000737:chemistry* / Q000145:classification / Q000235:genetics* / Q000378:metabolism; D002384:Catalysis; D045782:Hemiterpenes / Q000737:chemistry; D006801:Humans; D008968:Molecular Conformation; D008969:Molecular Sequence Data; D009943:Organophosphorus Compounds / Q000737:chemistry; D010802:Phylogeny; D010944:Plants / Q000201:enzymology*; D013729:Terpenes / Q000737:chemistry* / Q000378:metabolism
chemical_list: D045782:Hemiterpenes; D009943:Organophosphorus Compounds; D013729:Terpenes; C004809:isopentenyl pyrophosphate; D019748:Carbon-Carbon Double Bond Isomerases; C021453:isopentenyldiphosphate delta-isomerase