title: Effect of an exon 1 mutation in the myostatin gene on the growth traits of the Bian chicken.
abstract: Myostatin (MSTN), or growth and differentiation factor 8 (GDF8), is a member of the transforming growth factor (TGF)-β superfamily. This family functions as a negative regulator of skeletal muscle development and growth in mammals. Single-nucleotide polymorphisms in exon 1 of the Bian chicken myostatin gene were detected by polymerase chain reaction-restriction fragment length polymorphism. A mutation (c.234G>A) in exon 1 was found. Female Bian chickens of genotypes AA and GA had significantly higher body weights than those of genotype GG (P < 0.05 or P < 0.01) from 6 to 18 weeks of age. These results suggested that the mutation c.234G>A in exon 1 could be used as a genetic marker for Bian chicken growth traits.
authors.affiliation: College of Animal Science and Technology, Yangzhou University, China.
authors.forename: G X
authors.initials: GX
authors.lastname: Zhang
authors.forename: X H
authors.initials: XH
authors.lastname: Zhao
authors.forename: J Y
authors.initials: JY
authors.lastname: Wang
authors.forename: F X
authors.initials: FX
authors.lastname: Ding
authors.forename: L
authors.initials: L
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001835:Body Weight; D002645:Chickens / Q000145:classification / Q000235:genetics* / Q000254:growth & development*; D005091:Exons; D005260:Female; D005819:Genetic Markers; D005838:Genotype; D009154:Mutation; D055435:Myostatin / Q000235:genetics* / Q000378:metabolism; D010641:Phenotype; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide
chemical_list: D005819:Genetic Markers; D055435:Myostatin