title: Synthesis and biological evaluation of some novel thiazole substituted benzotriazole derivatives.
abstract: A series of novel hybrid molecules 4a-y containing thiazole and benzotriazole templates were designed and synthesized. The structures of the synthesized compounds were elucidated by IR, (1)H NMR, (13)C NMR and mass spectral data. All the synthesized compounds were tested for their antimicrobial activity (zone of inhibition) against Gram-positive, Gram-negative strains of bacteria as well as fungal strains. After that minimum inhibitory concentrations (MICs), minimum bactericidal concentrations (MBCs) and minimum fungicidal concentrations (MFCs) of all the synthesized compounds were determined. The investigation of antimicrobial screening data revealed that most of the tested compounds showed moderate to good microbial inhibitions.
authors.affiliation: Department of Chemistry, K.T.H.M. College, Nashik 422005, India.
authors.forename: Nitin D
authors.initials: ND
authors.lastname: Gaikwad
authors.forename: Sachin V
authors.initials: SV
authors.lastname: Patil
authors.forename: Vivek D
authors.initials: VD
authors.lastname: Bobade
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D014230:Triazoles; C012771:benzotriazole