title: Adipocytokines and obesity-linked disorders.
abstract: Obesity is closely associated with an increased risk for metabolic and cardiovascular diseases. Adipose tissue produces a number of secretory bioactive substances, also known as adipocytokines or adipokines, which directly affect adjacent or distant organs. Most adipocytokines are pro-inflammatory, thereby promoting the obesity-linked disorders. In contrast, there are a small number of adipocytokines that exhibit antiinflammatory properties. It is now recognized that dysregulated production or secretion of adipocytokines caused by adipocyte dysfunction leads to the development of obesity-linked complications. In this review, we focus on the functional role of several adipocytokines in metabolic and cardiovascular diseases.
authors.affiliation: Department of Molecular Cardiology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho Showa-ku, Nagoya, 466-8550, Japan. nouchi@med.nagoya-u.ac.jp
authors.forename: Noriyuki
authors.initials: N
authors.lastname: Ouchi
authors.forename: Koji
authors.initials: K
authors.lastname: Ohashi
authors.forename: Rei
authors.initials: R
authors.lastname: Shibata
authors.forename: Toyoaki
authors.initials: T
authors.lastname: Murohara
mesh_terms: D054392:Adipokines / Q000378:metabolism*; D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D002318:Cardiovascular Diseases / Q000209:etiology* / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000209:etiology* / Q000378:metabolism; D018836:Inflammation Mediators / Q000378:metabolism*; D008659:Metabolic Diseases / Q000209:etiology* / Q000378:metabolism; D009765:Obesity / Q000150:complications* / Q000378:metabolism; D012307:Risk Factors
chemical_list: D054392:Adipokines; D018836:Inflammation Mediators