title: Increased ischemia-modified albumin levels in patients with gastric cancer.
abstract: Reactive oxygen species (ROS) are found in the development stages of carcinogenesis. Fifty two patients with gastric cancer and 35 controls were enrolled in this trial. IMA, MDA, Total Oxidant Status (TOS), Total Antioxidant Status (TAS) and Oxidative Stress Index (OSI) were evaluated. There was a significant increase in IMA and MDA levels in the patient group (0.405±0.111, 0.271±0.066; p= 0.0001 and 0.207±0.251, 0.077±0.103; p= 0.004 respectively). TOS was also higher in the patient group but it was not statistically different. TAS was statistically lower and there was significant difference in OSI (0.621±0.394, 0.996±0.37; p=0.0001 and 9.68±18.2, 2.9±3.85; p=0.001 respectively). The areas under receiver operating characteristics curves for the determination of gastric cancer were 0.842 for IMA and 0.708 for MDA. Increased levels of IMA, MDA and oxidative stress index were detected and this condition is associated with the impairment of oxidant-antioxidant balance.
authors.affiliation: Division of Medical Oncology, Karadeniz Technical University Faculty of Medicine, Trabzon, Turkey. evrenfidan@yahoo.com
authors.forename: E
authors.initials: E
authors.lastname: Fidan
authors.forename: A
authors.initials: A
authors.lastname: Mentese
authors.forename: H
authors.initials: H
authors.lastname: Kavgaci
authors.forename: A
authors.initials: A
authors.lastname: Orem
authors.forename: S
authors.initials: S
authors.lastname: Fidan
authors.forename: A
authors.initials: A
authors.lastname: Uzun
authors.forename: F
authors.initials: F
authors.lastname: Ozdemir
authors.forename: F
authors.initials: F
authors.lastname: Aydin
mesh_terms: D000975:Antioxidants / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000378:metabolism*; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007511:Ischemia / Q000503:physiopathology*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008875:Middle Aged; D016877:Oxidants / Q000378:metabolism; D018384:Oxidative Stress; D011379:Prognosis; D012372:ROC Curve; D017382:Reactive Oxygen Species / Q000378:metabolism; D012709:Serum Albumin / Q000378:metabolism*; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology*
chemical_list: D000975:Antioxidants; D014408:Biomarkers, Tumor; D016877:Oxidants; D017382:Reactive Oxygen Species; D012709:Serum Albumin; D008315:Malondialdehyde