title: Influence of MHC class I and II haplotypes on the experimental infection of Mauritian cynomolgus macaques with SHIVSF162P4cy.
abstract: Mauritian cynomolgus macaques (MCM) are widely used in human immunodeficiency virus research because of their restricted major histocompatibility complex (MHC) diversity which provides the opportunity to address the influence of host factors on vaccine studies. We herein report the impact of MHC haplotype on the outcome of 21 MCM infections with the CCR5-tropic simian/human immunodeficiency virus (SHIV)(SF162P4cy). MCM were susceptible to SHIV(SF162P4cy) infection as shown by viremia and loss of CD4+ T cells. A significant association between haplotype M7 (class IA, IB, II) and persistent viremia was observed in chronic phase, whereas recombinant class IA haplotype was associated with a reduction of viral RNA during acute infection. Class IB M4 haplotype displayed significantly lower acute phase provirus copy numbers. In addition, statistical analysis indicated a detrimental effect of haplotype M4 (class IA, IB) on the course of infection as indicated by lower CD4+ T-cell levels during chronic infection. A decrease in post-acute phase CD4+ T-cell numbers was also observed in haplotype M2 animals. This is the first report that documents the effects of host MHC class I and II molecules on the SHIV(SF162P4cy) infection in MCM, particularly with regard to the association between recombinant class IA, M4, and M7 haplotypes and the dynamic of viral replication and level of CD4+ T cells.
authors.affiliation: National AIDS Center, Istituto Superiore Di Sanità, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Borsetti
authors.forename: M T
authors.initials: MT
authors.lastname: Maggiorella
authors.forename: L
authors.initials: L
authors.lastname: Sernicola
authors.forename: S
authors.initials: S
authors.lastname: Bellino
authors.forename: F
authors.initials: F
authors.lastname: Ferrantelli
authors.forename: R
authors.initials: R
authors.lastname: Belli
authors.forename: D
authors.initials: D
authors.lastname: Fulgenzi
authors.forename: E T
authors.initials: ET
authors.lastname: Mee
authors.forename: N J
authors.initials: NJ
authors.lastname: Rose
authors.forename: A
authors.initials: A
authors.lastname: Cafaro
authors.forename: B
authors.initials: B
authors.lastname: Ensoli
authors.forename: F
authors.initials: F
authors.lastname: Titti
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000473:pathology; D002452:Cell Count; D018450:Disease Progression; D015658:HIV Infections / Q000235:genetics / Q000276:immunology; D006239:Haplotypes; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D008252:Macaca fascicularis; D023421:Models, Animal; D016097:Simian Acquired Immunodeficiency Syndrome / Q000235:genetics* / Q000276:immunology / Q000503:physiopathology; D015302:Simian Immunodeficiency Virus / Q000502:physiology*; D014779:Virus Replication / Q000235:genetics / Q000276:immunology
chemical_list: D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II