title: Predictors of short- and long-term clinical outcome in schizophrenic psychosis--the Northern Finland 1966 Birth Cohort study.
abstract: OBJECTIVE
  Since the outcome in schizophrenia is heterogeneous and often poor, identification of specific predictors of outcome would be useful in clinical practice.
  
  
  METHODS
  Subjects with schizophrenic psychoses (n=103) included in the Northern Finland 1966 Birth Cohort (n=12,058), representing the general population, were followed-up for an average of 16.4 years. Predictor and outcome data were collected from the nationwide Finnish Hospital Discharge Register, hospital records and interviews.
  
  
  RESULTS
  Insidious onset of illness predicted a rehospitalization due to psychosis in the 2 years after the initial discharge. Being single, having an early onset, insidious onset, suicidal ideations upon the first admission, a rehospitalization and a high number of treatment days due to psychosis in the early stages of the illness all predicted a poorer clinical outcome in the longer term, after a minimum follow-up of 10 years.
  
  
  CONCLUSIONS
  This population-based study indicates that clinical and sociodemographic factors around the onset of illness have significance for the long-term outcome in schizophrenia. These prognostic factors should be taken into account in clinical practice.
authors.affiliation: Institute of Clinical Medicine, Department of Psychiatry, University of Oulu, P.O. Box 5000, 90014 Oulu, Finland. majantti@paju.oulu.fi
authors.forename: P
authors.initials: P
authors.lastname: Juola
authors.forename: J
authors.initials: J
authors.lastname: Miettunen
authors.forename: J
authors.initials: J
authors.lastname: Veijola
authors.forename: M
authors.initials: M
authors.lastname: Isohanni
authors.forename: E
authors.initials: E
authors.lastname: Jääskeläinen
mesh_terms: D000328:Adult; D017668:Age of Onset; D014150:Antipsychotic Agents / Q000627:therapeutic use; D015331:Cohort Studies; D005260:Female; D005387:Finland / Q000453:epidemiology; D006760:Hospitalization; D006801:Humans; D008297:Male; D008875:Middle Aged; D011618:Psychotic Disorders / Q000188:drug therapy / Q000453:epidemiology* / Q000523:psychology; D012559:Schizophrenia / Q000188:drug therapy / Q000453:epidemiology*; D012565:Schizophrenic Psychology; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents