title: Host genetic susceptibility to severe dengue infection.
abstract: Epidemiological evidence indicates that host genetic factors are relevant and predispose DHF/DSS development. Here, we review the host genetic studies concerning human leucocyte antigens, antibody receptors, immune/inflammatory mediators, attachment molecules, cytokines and other factors exerting an immunoregulatory effect as well as the current genome-wide association studies. We also discuss some viewpoints on future challenges related to the design of safe and effective prevention and treatment options.
authors.affiliation: Department of Microbiology and Immunology, Pasteur Institute Ho Chi Minh City, Vietnam.
authors.forename: Nguyen Thi Phuong
authors.initials: NT
authors.lastname: Lan
authors.forename: Kenji
authors.initials: K
authors.lastname: Hirayama