title: Axonally translated SMADs link up BDNF and retrograde BMP signaling.
abstract: Axonal target-derived BMP and neurotrophin signaling are both known to regulate neuronal gene expression, differentiation, and axon growth. In this issue of Neuron, Ji and Jaffrey (2012) discovered that BMP-signaling endosomes depend on BDNF-induced axonal synthesis of SMADs to retrogradely regulate transcription in developing trigeminal neurons, providing a mechanism of integrating the two target-derived signals.
authors.affiliation: Department of Cell Biology, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: Jun
authors.initials: J
authors.lastname: Takatoh
authors.forename: Fan
authors.initials: F
authors.lastname: Wang
mesh_terms: D000818:Animals; D001370:Axonal Transport / Q000502:physiology*; D001369:Axons / Q000378:metabolism*; D002454:Cell Differentiation / Q000502:physiology*; D051896:Smad Proteins, Receptor-Regulated / Q000096:biosynthesis*; D051898:Smad1 Protein / Q000096:biosynthesis*; D051902:Smad5 Protein / Q000096:biosynthesis*; D051904:Smad8 Protein / Q000096:biosynthesis*; D012668:Trigeminal Ganglion / Q000378:metabolism*
chemical_list: D051896:Smad Proteins, Receptor-Regulated; D051898:Smad1 Protein; D051902:Smad5 Protein; D051904:Smad8 Protein