title: Emergence of fluoroquinolone resistance in Neisseria gonorrhoeae isolates from four clinics in three regions of Kenya.
abstract: We have recently reported high levels of fluoroquinolone resistance in a single region of Kenya. In this article, we report high prevalence of fluoroquinolone resistance (53.2%) in Neisseria gonorrhoeae isolates from 4 clinics in 3 additional regions of Kenya. These findings highlight the need to change first-line treatment in these settings and the need to evaluate empirical management guidelines for treatment of gonococcal infection in Kenya.
authors.affiliation: University of Manitoba, Faculty of Medicine, Department of Medical Microbiology and Infectious Diseases, Winnipeg, MB, Canada. plagacewiens@dsmanitoba.ca
authors.forename: Philippe R S
authors.initials: PR
authors.lastname: Lagace-Wiens
authors.forename: Sarah
authors.initials: S
authors.lastname: Duncan
authors.forename: Joshua
authors.initials: J
authors.lastname: Kimani
authors.forename: Alexander
authors.initials: A
authors.lastname: Thiong'o
authors.forename: Juma
authors.initials: J
authors.lastname: Shafi
authors.forename: Scott
authors.initials: S
authors.lastname: McClelland
authors.forename: Eduard J
authors.initials: EJ
authors.lastname: Sanders
authors.forename: George
authors.initials: G
authors.lastname: Zhanel
authors.forename: Nicholas
authors.initials: N
authors.lastname: Muraguri
authors.forename: Supriya D
authors.initials: SD
authors.lastname: Mehta
mesh_terms: D000328:Adult; D024881:Drug Resistance, Bacterial; D005260:Female; D024841:Fluoroquinolones / Q000008:administration & dosage* / Q000494:pharmacology; D006069:Gonorrhea / Q000188:drug therapy* / Q000517:prevention & control / Q000635:transmission; D006801:Humans; D007630:Kenya / Q000453:epidemiology; D008297:Male; D008403:Mass Screening; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects / Q000302:isolation & purification*; D015995:Prevalence; D018571:Sentinel Surveillance
chemical_list: D024841:Fluoroquinolones