title: Simple and efficient solid-phase preparation of azido-peptides.
abstract: A shelf-stable and easily prepared diazotransfer reagent, imidazole-1-sulfonyl azide hydrochloride, was used to transform the N-terminus of a model peptide on solid phase into an azide moiety. It is demonstrated that this conversion was accomplished within 30 min with high efficiency under aqueous conditions on a NovaPEG resin or in DMF on polystyrene beads.
authors.affiliation: Radboud University, Institute for Molecules and Materials, Heyendaalseweg 135, 6525 AJ Nijmegen, The Netherlands.
authors.forename: Morten B
authors.initials: MB
authors.lastname: Hansen
authors.forename: Theodorus H M
authors.initials: TH
authors.lastname: van Gurp
authors.forename: Jan C M
authors.initials: JC
authors.lastname: van Hest
authors.forename: Dennis W P M
authors.initials: DW
authors.lastname: Löwik
mesh_terms: D001386:Azides / Q000737:chemistry*; D007093:Imidazoles / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D011137:Polystyrenes / Q000737:chemistry
chemical_list: D001386:Azides; D007093:Imidazoles; D010455:Peptides; D011137:Polystyrenes; C523862:imidazole-1-sulfonyl azide hydrochloride