title: A prospective study to evaluate the efficacy of an intracardiac electrogram-based atrioventricular and interventricular intervals optimization method in cardiac resynchronization therapy.
abstract: BACKGROUND
  Cardiac resynchronization therapy (CRT) with biventricular pacing improves cardiac function, functional capacity and quality of life in selected patients with heart failure. The current study aimed to evaluate the efficacy of the intracardiac electrogram (IEGM)-based optimization method, QuickOpt(TM), in Chinese patients treated with CRT.
  
  
  METHODS
  Aortic time velocity integrals (AVTI) achieved at the sensed atrioventricular (AV), paced AV and interventricular (VV) interval settings recommended by both QuickOpt(TM) and standard echocardiographic optimization were measured in 101 patients. Consistency and the strength of the relationship between the two timing cycle optimization methods were assessed by intra-class correlation coefficient (ICC).
  
  
  RESULTS
  The ICC showed good agreement and correlation with what the AVTI achieved at the optimal sensed AV (ICC = 0.9683 (0.9535 - 0.9785)), paced AV (ICC = 0.9642 (0.9475 - 0.9757)) and VV (ICC = 0.9730 (0.9602 - 0.9817)) interval settings determined by the two optimization methods. The average time required by echocardiographic optimization and by QuickOpt(TM) were (78.32 ± 32.40) minutes and (1.98 ± 1.64) minutes respectively (P < 0.0001).
  
  
  CONCLUSIONS
  The QuickOpt(TM) algorithm provides a quicker, simpler and reliable alternative to the standard method for timing cycle optimization.
authors.affiliation: Department of Cardiology, Cardiovascular Institute & Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100037, China. drhua@vip.sina.com
authors.forename: Wei
authors.initials: W
authors.lastname: Hua
authors.forename: Dong-Mei
authors.initials: DM
authors.lastname: Wang
authors.forename: Lin
authors.initials: L
authors.lastname: Cai
authors.forename: Chao-Feng
authors.initials: CF
authors.lastname: Sun
authors.forename: Guo-Sheng
authors.initials: GS
authors.lastname: Fu
authors.forename: Yu-Tang
authors.initials: YT
authors.lastname: Wang
authors.forename: Ji
authors.initials: J
authors.lastname: Yan
authors.forename: Zhi-Ling
authors.initials: ZL
authors.lastname: Luo
authors.forename: Jing
authors.initials: J
authors.lastname: Xu
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Wang
authors.forename: Geng
authors.initials: G
authors.lastname: Xu
authors.forename: Fa-Rong
authors.initials: FR
authors.lastname: Shen
authors.forename: Wei
authors.initials: W
authors.lastname: Xu
authors.forename: Jing-Feng
authors.initials: JF
authors.lastname: Wang
authors.forename: Xue-Jun
authors.initials: XJ
authors.lastname: Ren
authors.forename: Wei
authors.initials: W
authors.lastname: Jin
authors.forename: Nan
authors.initials: N
authors.lastname: Zhang
authors.forename: Elizabeth Oi-Yan
authors.initials: EO
authors.lastname: Lau
authors.forename: Shu
authors.initials: S
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D058406:Cardiac Resynchronization Therapy / Q000379:methods*; D022062:Electrophysiologic Techniques, Cardiac / Q000379:methods*; D005260:Female; D006333:Heart Failure / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies