title: Topical application effect of the isolectin hydrogel (Cramoll 1,4) on second-degree burns: experimental model.
abstract: This study aimed at evaluating the use of hydrogel isolectin in the treatment of second-degree burns. Twenty male rats were randomly divided into two groups (G1 = treatment with hydrogel containing 100 μg/mL Cramoll 1,4 and G2 = Control, hydrogel). After 7, 14, 21, 28, and 35 days, animals were euthanized. On the 7th day, G1 showed intense exudates, necrosis and edema. On the 14th day, G1 showed tissue reepithelialization and moderate autolysis. On the 21st day, G1 showed intense fibroblastic proliferation, presence of dense collagen, and moderate fibrosis. On the 28th day, G1 showed complete tissue epithelialization. On the 35th day, G1 showed modeled dense collagen. The significant wound contraction was initiated from day, 14 in the G1. There were no significant differences in biochemical and hematological parameters analyzed. These results extend the potential of therapeutic applications for Cramoll 1,4 in the treatment of thermal burns.
authors.affiliation: Programa de Pós-Graduação em Ciências Biológicas, Universidade Federal de Pernambuco, 50670-901 Recife, PE, Brazil. dstpereira@yahoo.com.br
authors.forename: Danielle dos Santos Tavares
authors.initials: Ddos S
authors.lastname: Pereira
authors.forename: Maria Helena Madruga
authors.initials: MH
authors.lastname: Lima-Ribeiro
authors.forename: Ralph
authors.initials: R
authors.lastname: Santos-Oliveira
authors.forename: Carmelita de Lima Bezerra
authors.initials: Cde L
authors.lastname: Cavalcanti
authors.forename: Nicodemos Teles
authors.initials: NT
authors.lastname: de Pontes-Filho
authors.forename: Luana Cassandra Breitenbach Barroso
authors.initials: LC
authors.lastname: Coelho
authors.forename: Ana Maria dos Anjos
authors.initials: AM
authors.lastname: Carneiro-Leão
authors.forename: Maria Tereza dos Santos
authors.initials: MT
authors.lastname: Correia
mesh_terms: D000287:Administration, Topical; D000818:Animals; D001774:Blood Chemical Analysis; D002056:Burns / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D004195:Disease Models, Animal; D004848:Epithelium / Q000473:pathology; D007887:Fabaceae / Q000737:chemistry; D006386:Hemagglutination Tests; D006403:Hematologic Tests; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000494:pharmacology*; D008297:Male; D037121:Plant Lectins / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D018709:Statistics, Nonparametric; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D037121:Plant Lectins; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate