title: Versatile logic devices based on programmable DNA-regulated silver-nanocluster signal transducers.
abstract: A DNA-encoding strategy is reported for the programmable regulation of the fluorescence properties of silver nanoclusters (AgNCs). By taking advantage of the DNA-encoding strategy, aqueous AgNCs were used as signal transducers to convert DNA inputs into fluorescence outputs for the construction of various DNA-based logic gates (AND, OR, INHIBIT, XOR, NOR, XNOR, NAND, and a sequential logic gate). Moreover, a biomolecular keypad that was capable of constructing crossword puzzles was also fabricated. These AgNC-based logic systems showed several advantages, including a simple transducer-introduction strategy, universal design, and biocompatible operation. In addition, this proof of concept opens the door to a new generation of signal transducer materials and provides a general route to versatile biomolecular logic devices for practical applications.
authors.affiliation: Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022 PR China.
authors.forename: Zhenzhen
authors.initials: Z
authors.lastname: Huang
authors.forename: Yu
authors.initials: Y
authors.lastname: Tao
authors.forename: Fang
authors.initials: F
authors.lastname: Pu
authors.forename: Jinsong
authors.initials: J
authors.lastname: Ren
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Qu
mesh_terms: D004247:DNA / Q000737:chemistry*; D005453:Fluorescence; D053768:Metal Nanoparticles / Q000737:chemistry*; D015335:Molecular Probes / Q000737:chemistry; D012834:Silver / Q000737:chemistry*
chemical_list: D015335:Molecular Probes; D012834:Silver; D004247:DNA