title: [Influences of compound whole grain on oxidative stress to hyperlipidemia population].
abstract: OBJECTIVE
  To explore the influence of compound whole grain complex antioxidant chain on oxidative stress to the hyperlipidemia population.
  
  
  METHODS
  From March 2008 to March 2009, 418 hyperlipemia residents (45 to 75 years of age) of Han group were screened from 3 main districts in Nanjing, according to the community, blood lipids and oxidative indicators, stratified into intervention and control group by quasi-experimental design. The intervention group (212 individuals) were provided with compound whole grain and health education while only health education was provided for the control group (206 individuals). Body mass index (BMI), waist-to-hip ratio (WHR), total cholesterol (TC), triglyceride (TG) and high density lipoprotein cholesterol (HDL-C) and oxidative indicators (including T-AOC, MDA, SOD, GSH-Px) were measured before and after the one-year intervention period. Analyses of the correlation between posture, biochemical markers and oxidative stress indicators before and after intervention were carried out.
  
  
  RESULTS
  After intervention, BMI ((25.53 ± 2.77) kg/m(2)), WHR (0.82 ± 0.03), TC ((4.60 ± 0.98) mmol/L), TG ((1.26 ± 0.88) mmol/L) in the intervention group were decreased significantly compared to the levels of BMI ((26.60 ± 3.18) kg/m(2)), WHR (0.93 ± 0.05), TC ((4.97 ± 1.02) mmol/L), TG ((1.98 ± 1.11) mmol/L) in the control group (all P values < 0.05); while HDL-C ((1.34 ± 0.26) mmol/L) in the intervention group was increased significantly compared to the level of HDL-C ((1.18 ± 0.17) mmol/L) in the control group (P < 0.05); After intervention, levels of T-AOC (19.52 ± 0.81), SOD ((85.42 ± 21.65) U/ml) and GSH-Px ((128.26 ± 33.65) µmol/L) were increased significantly compared to the levels of T-AOC (11.11 ± 1.30), SOD ((78.68 ± 30.48) U/ml) and GSH-Px ((118.48 ± 24.19) µmol/L) in the control group (all P values < 0.05); while MDA ((1.78 ± 1.16) nmol/ml) decreased significantly compared to the level of MDA ((2.12 ± 1.37) nmol/ml in the control group (P < 0.05); Pearson product moment correlation analysis showed that: T-AOC with TC, TG, BMI showed a negative correlation (r values were -0.258, -0.266, -0.230, respectively, all P values < 0.05), while with HDL-C was a positive correlation (r values was 0.194, P < 0.05); SOD with TC, TG, BMI showed a negative correlation (r values were -0.282, -0.311, -0.217, respectively, all P values < 0.05), while with HDL-C was a positive correlation (r values was 0.169, P < 0.05).
  
  
  CONCLUSIONS
  Compound whole grain could improve lipid metabolism to the hyperlipidemia population. There was a correlation between common human metabolism and the levels of oxidative stress.
authors.affiliation: Department of Nutrition and Food Hygiene, Public Health School, Southeast University, Nanjing 210009, China.
authors.forename: Jing
authors.initials: J
authors.lastname: Chi
authors.forename: Qun
authors.initials: Q
authors.lastname: Zhang
authors.forename: Cheng-Kai
authors.initials: CK
authors.lastname: Zhai
authors.forename: Hong
authors.initials: H
authors.lastname: Zhang
authors.forename: Shu-Fen
authors.initials: SF
authors.lastname: Han
authors.forename: Ya-Qi
authors.initials: YQ
authors.lastname: Liu
authors.forename: Si-Yu
authors.initials: SY
authors.lastname: Zhou
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000975:Antioxidants; D002681:China / Q000453:epidemiology; D004032:Diet; D004034:Diet Surveys; D002523:Edible Grain; D005260:Female; D006266:Health Education; D006801:Humans; D006949:Hyperlipidemias / Q000453:epidemiology / Q000378:metabolism* / Q000517:prevention & control; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress
chemical_list: D000975:Antioxidants