title: Copper-catalyzed aerobic intramolecular carbo- and amino-oxygenation of alkynes for synthesis of azaheterocycles.
abstract: A synthetic method of highly substituted quinolines has been developed from N-(2-alkynylaryl)enamine carboxylates under Cu-catalyzed aerobic conditions via intramolecular carbo-oxygenation of alkynes. This strategy was further applied for N-alkynylamidines for amino-oxygenation of alkynes, leading to imidazole and quinazoline derivatives.
authors.affiliation: Division of Chemistry and Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore 637371, Singapore.
authors.forename: Kah Kah
authors.initials: KK
authors.lastname: Toh
authors.forename: Stephen
authors.initials: S
authors.lastname: Sanjaya
authors.forename: Sophian
authors.initials: S
authors.lastname: Sahnoun
authors.forename: Sin Yee
authors.initials: SY
authors.lastname: Chong
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Chiba
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003300:Copper / Q000737:chemistry*; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D015394:Molecular Structure; D011799:Quinazolines / Q000138:chemical synthesis* / Q000737:chemistry; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000480:Alkynes; D007093:Imidazoles; D011799:Quinazolines; D011804:Quinolines; D003300:Copper