title: Quantitative trait loci for resistance to infection in sheep using a live Salmonella Abortusovis vaccine.
abstract: Quantitative trait loci (QTL) mapping for susceptibility to a Salmonella Abortusovis vaccinal strain was performed using an experimental design involving 30 Romane sheep sire families (1216 progenies). Nine QTL corresponding to bacterial load, weight variations and antibody response criteria were mapped on eight chromosomes, including the major histocompatibility complex area on chromosome 20. Surprisingly, none was found to be significant in the SLC11A1 region (formerly NRAMP1) that has been shown to influence Salmonella susceptibility in other species.
authors.affiliation: INRA, UR1282, Infectiologie Animale et Santé Publique, 37380 Nouzilly, France.
authors.forename: I
authors.initials: I
authors.lastname: Lantier
authors.forename: C R
authors.initials: CR
authors.lastname: Moreno
authors.forename: P
authors.initials: P
authors.lastname: Berthon
authors.forename: G
authors.initials: G
authors.lastname: Sallé
authors.forename: F
authors.initials: F
authors.lastname: Pitel
authors.forename: L
authors.initials: L
authors.lastname: Schibler
authors.forename: A V
authors.initials: AV
authors.lastname: Gautier-Bouchardon
authors.forename: R
authors.initials: R
authors.lastname: Boivin
authors.forename: J L
authors.initials: JL
authors.lastname: Weisbecker
authors.forename: D
authors.initials: D
authors.lastname: François
authors.forename: J
authors.initials: J
authors.lastname: Bouix
authors.forename: E P
authors.initials: EP
authors.lastname: Cribiu
authors.forename: J M
authors.initials: JM
authors.lastname: Elsen
authors.forename: F
authors.initials: F
authors.lastname: Lantier
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D002874:Chromosome Mapping / Q000662:veterinary; D015169:Colony Count, Microbial / Q000662:veterinary; D011110:Polymorphism, Genetic; D040641:Quantitative Trait Loci; D012481:Salmonella Infections, Animal / Q000235:genetics* / Q000276:immunology; D022562:Salmonella Vaccines / Q000008:administration & dosage / Q000276:immunology*; D019779:Salmonella enterica / Q000187:drug effects*; D012756:Sheep; D012757:Sheep Diseases / Q000235:genetics* / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D022562:Salmonella Vaccines