title: Structural modifications that alter the P-glycoprotein efflux properties of compounds.
authors.affiliation: Envoy Therapeutics, 555 Heritage Drive, Jupiter Florida 33458, United States. stephen.hitchcock@envoytherapeutics.com
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Hitchcock
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism*; D000818:Animals; D001812:Blood-Brain Barrier / Q000378:metabolism; D002460:Cell Line; D002491:Central Nervous System Agents / Q000737:chemistry* / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use; D002493:Central Nervous System Diseases / Q000188:drug therapy* / Q000378:metabolism; D015195:Drug Design; D006801:Humans; D008958:Models, Molecular; D010539:Permeability; D013329:Structure-Activity Relationship
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D002491:Central Nervous System Agents