title: Multiple 3D inversion recovery imaging for volume T1 mapping of the heart.
abstract: In this article, a three-dimensional inversion recovery sequence was optimized with the aim of generating in vivo volume T(1) maps of the heart using a 1.5-T MR system. Acquisitions were performed before and after gadolinium diethylenetriamine penta-acetic acid (Gd-DTPA) administration in one patient with hypertrophic cardiomyopathy and in two healthy volunteers. Data were acquired with a multishot fast field echo readout using both ECG and respiratory triggers. A dedicated phantom, composed of four solutions with different T(1) values, was positioned on the subjects' thoracic region to perform patient-specific calibration. Pixel based T(1) maps were calculated with a custom Matlab(®) code. Phantom measurements showed a good accuracy of the technique and in vivo T(1) estimation of liver, skeletal muscle, myocardium, and blood resulted in good agreement with values reported in the literature. Multiple three-dimensional inversion recovery technique is a feasible and accurate method to perform T(1) volume mapping.
authors.affiliation: AFaR, Department of Medical Physics, S. Giovanni Calibita, Fatebenefratelli Hospital, Rome, Italy. coniglio.fbf.isola@gmail.com
authors.forename: A
authors.initials: A
authors.lastname: Coniglio
authors.forename: P
authors.initials: P
authors.lastname: Di Renzi
authors.forename: G
authors.initials: G
authors.lastname: Vilches Freixas
authors.forename: G
authors.initials: G
authors.lastname: Della Longa
authors.forename: A
authors.initials: A
authors.lastname: Santarelli
authors.forename: R
authors.initials: R
authors.lastname: Capparella
authors.forename: B
authors.initials: B
authors.lastname: Nardiello
authors.forename: C
authors.initials: C
authors.lastname: Loiudice
authors.forename: S
authors.initials: S
authors.lastname: Bianchi
authors.forename: M
authors.initials: M
authors.lastname: D'Arienzo
authors.forename: L
authors.initials: L
authors.lastname: Begnozzi
mesh_terms: D000328:Adult; D000368:Aged; D002138:Calibration; D002312:Cardiomyopathy, Hypertrophic / Q000473:pathology*; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D006321:Heart / Q000033:anatomy & histology*; D006801:Humans; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008099:Liver / Q000033:anatomy & histology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology*; D019047:Phantoms, Imaging
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA