title: Studies of bone morphogenetic protein-based surgical repair.
abstract: Over the past several decades, recombinant human bone morphogenetic proteins (rhBMPs) have been the most extensively studied and widely used osteoinductive agents for clinical bone repair. Since rhBMP-2 and rhBMP-7 were cleared by the U.S. Food and Drug Administration for certain clinical uses, millions of patients worldwide have been treated with rhBMPs for various musculoskeletal disorders. Current clinical applications include treatment of long bone fracture non-unions, spinal surgeries, and oral maxillofacial surgeries. Considering the growing number of recent publications related to clincal research of rhBMPs, there exists enormous promise for these proteins to be used in bone regenerative medicine. The authors take this opportunity to review the rhBMP literature paying specific attention to the current applications of rhBMPs in bone repair and spine surgery. The prospective future of rhBMPs delivered in combination with tissue engineered scaffolds is also reviewed.
authors.affiliation: Department of Orthopaedic Surgery, University of Connecticut Health Center, School of Medicine, Farmington, CT 06030, USA.
authors.forename: Kevin W-H
authors.initials: KW
authors.lastname: Lo
authors.forename: Bret D
authors.initials: BD
authors.lastname: Ulery
authors.forename: Keshia M
authors.initials: KM
authors.lastname: Ashe
authors.forename: Cato T
authors.initials: CT
authors.lastname: Laurencin
mesh_terms: D000818:Animals; D055396:Bone Morphogenetic Protein 2 / Q000008:administration & dosage* / Q000627:therapeutic use; D055419:Bone Morphogenetic Protein 7 / Q000008:administration & dosage* / Q000627:therapeutic use; D001861:Bone Regeneration; D001842:Bone and Bones / Q000378:metabolism; D017277:Drug Approval; D016503:Drug Delivery Systems; D006801:Humans; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000627:therapeutic use; D023822:Tissue Engineering / Q000379:methods; D054457:Tissue Scaffolds / Q000737:chemistry; D014481:United States; D014486:United States Food and Drug Administration
chemical_list: C525718:BMP2 protein, human; C525819:BMP7 protein, human; D055396:Bone Morphogenetic Protein 2; D055419:Bone Morphogenetic Protein 7; D011994:Recombinant Proteins