title: Distinctive roles for amygdalar CREB in reconsolidation and extinction of fear memory.
abstract: Cyclic AMP response element binding protein (CREB) plays a critical role in fear memory formation. Here we determined the role of CREB selectively within the amygdala in reconsolidation and extinction of auditory fear. Viral overexpression of the inducible cAMP early repressor (ICER) or the dominant-negative mCREB, specifically within the lateral amygdala disrupted reconsolidation of auditory fear memories. In contrast, manipulations of CREB in the amygdala did not modify extinction of fear. These findings suggest that the role of CREB in modulation of memory after retrieval is dynamic and that CREB activity in the basolateral amygdala is involved in fear memory reconsolidation.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA.
authors.forename: Natalie C
authors.initials: NC
authors.lastname: Tronson
authors.forename: Shari L
authors.initials: SL
authors.lastname: Wiseman
authors.forename: Rachael L
authors.initials: RL
authors.lastname: Neve
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Nestler
authors.forename: Peter
authors.initials: P
authors.lastname: Olausson
authors.forename: Jane R
authors.initials: JR
authors.lastname: Taylor
mesh_terms: D000679:Amygdala / Q000378:metabolism*; D000818:Animals; D017362:Cyclic AMP Response Element-Binding Protein / Q000378:metabolism*; D005108:Extinction, Psychological / Q000502:physiology*; D005239:Fear / Q000502:physiology; D008568:Memory / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D017362:Cyclic AMP Response Element-Binding Protein