title: MSV3d: database of human MisSense Variants mapped to 3D protein structure.
abstract: The elucidation of the complex relationships linking genotypic and phenotypic variations to protein structure is a major challenge in the post-genomic era. We present MSV3d (Database of human MisSense Variants mapped to 3D protein structure), a new database that contains detailed annotation of missense variants of all human proteins (20 199 proteins). The multi-level characterization includes details of the physico-chemical changes induced by amino acid modification, as well as information related to the conservation of the mutated residue and its position relative to functional features in the available or predicted 3D model. Major releases of the database are automatically generated and updated regularly in line with the dbSNP (database of Single Nucleotide Polymorphism) and SwissVar releases, by exploiting the extensive Décrypthon computational grid resources. The database (http://decrypthon.igbmc.fr/msv3d) is easily accessible through a simple web interface coupled to a powerful query engine and a standard web service. The content is completely or partially downloadable in XML or flat file formats. Database URL: http://decrypthon.igbmc.fr/msv3d.
authors.affiliation: Laboratoire de Bioinformatique et Génomique Intégratives, Institut de Génétique et de Biologie Moléculaire et Cellulaire (UMR7104), 67404 Illkirch.
authors.forename: Tien-Dao
authors.initials: TD
authors.lastname: Luu
authors.forename: Alin-Mihai
authors.initials: AM
authors.lastname: Rusu
authors.forename: Vincent
authors.initials: V
authors.lastname: Walter
authors.forename: Raymond
authors.initials: R
authors.lastname: Ripp
authors.forename: Luc
authors.initials: L
authors.lastname: Moulinier
authors.forename: Jean
authors.initials: J
authors.lastname: Muller
authors.forename: Thierry
authors.initials: T
authors.lastname: Toursel
authors.forename: Julie D
authors.initials: JD
authors.lastname: Thompson
authors.forename: Olivier
authors.initials: O
authors.lastname: Poch
authors.forename: Hoan
authors.initials: H
authors.lastname: Nguyen
mesh_terms: D019943:Amino Acid Substitution; D003628:Database Management Systems; D030562:Databases, Protein; D006801:Humans; D020407:Internet; D008958:Models, Molecular; D020125:Mutation, Missense; D020641:Polymorphism, Single Nucleotide; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry* / Q000235:genetics*
chemical_list: D011506:Proteins