title: Serum cystatin C is an early biomarker for assessment of renal function in burn patients.
abstract: BACKGROUND
  Early detection of renal dysfunction is important in burn patients. This study evaluated whether serum cystatin C (CysC) is a potentially accurate and sensitive marker for identification of reduced glomerular filtration rate (GFR) and the risk factors of impaired renal function in major burn patients.
  
  
  METHODS
  A total of 48 adult patients with major burn injury were enrolled. Renal function was assessed using serum creatinine (sCr), 24-h urinary creatinine clearance (24-hCrCl), sCr-based formulae and CysC-based formulae on the second day and seventh day post-burn.
  
  
  RESULTS
  There was a high prevalence (27.1%) of acute impaired renal function in major burn patients in the first week post-burn. CysC-based formulae for estimated GFR (eGFR) are more accurate and sensitive for detection of impaired renal function than sCr-based formulae. Multivariate logistic regression analysis demonstrated that age (OR, 2.08; 95% CI 1.26-4.77) and the percentage of burn area (OR, 3.41; 95% CI 1.64-6.95) were independent risk factors of impaired renal function.
  
  
  CONCLUSIONS
  The results of this study suggest that CysC is a more accurate and sensitive marker for identification of acute impaired renal function in major burn patients than sCr. It is important to measure CysC and calculate eGFR to prevent acute renal failure and modify drug doses in burn patients, especially those of older age and with major burn areas.
authors.affiliation: Burns Department, the First People’s Hospital of Shunde (The Affiliated Hospital at Shunde, Southern Medical University), Foshan, PR China.
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Cai
authors.forename: Zhaolin
authors.initials: Z
authors.lastname: Long
authors.forename: Lianduo
authors.initials: L
authors.lastname: Lin
authors.forename: Yudong
authors.initials: Y
authors.lastname: Feng
authors.forename: Naxi
authors.initials: N
authors.lastname: Zhou
authors.forename: Qifeng
authors.initials: Q
authors.lastname: Mai
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002056:Burns / Q000097:blood* / Q000150:complications / Q000503:physiopathology*; D055316:Cystatin C / Q000097:blood*; D060730:Glomerular Filtration Barrier; D005919:Glomerular Filtration Rate; D006801:Humans; D007674:Kidney Diseases / Q000097:blood / Q000150:complications / Q000503:physiopathology; D007677:Kidney Function Tests / Q000379:methods*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D013997:Time Factors; D055815:Young Adult
chemical_list: D015415:Biomarkers; D055316:Cystatin C