title: Assessment of platelet function in patients on antiplatelet therapy undergoing cardiac surgery: a review.
abstract: Increasing numbers of patients are undergoing cardiac surgery on dual antiplatelet therapy following previous percutaneous coronary intervention. The dilemma of stopping antiplatelet therapy prior to surgery with risk of stent thrombosis, versus continuation and risk of post-operative bleeding has received much debate. Currently, an accurate and standardised method of predicting antiplatelet drug efficacy has not yet been determined and significant inter-individual variance has been shown. This review focuses on the most widely used laboratory and point of care assays currently available to measure platelet function and recent published data evaluating these methods. Further studies may enable predictive values to be defined, to guide the practicing clinician in balancing the risk of thrombosis versus haemorrhage.
authors.affiliation: Department of Cardiothoracic Surgery, Imperial College Healthcare NHS Trust, Hammersmith Hospital, Du Cane Road, London W12 0HS, United Kingdom.
authors.forename: Ravi
authors.initials: R
authors.lastname: Patni
authors.forename: M Asghar
authors.initials: MA
authors.lastname: Nawaz
authors.forename: Antanas
authors.initials: A
authors.lastname: Macys
authors.forename: K M John
authors.initials: KM
authors.lastname: Chan
authors.forename: P
authors.initials: P
authors.lastname: Punjabi
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D006348:Cardiac Surgical Procedures; D005260:Female; D006801:Humans; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage*; D010979:Platelet Function Tests; D017410:Practice Guidelines as Topic; D015607:Stents / Q000009:adverse effects*; D013927:Thrombosis / Q000209:etiology / Q000628:therapy*
chemical_list: D010975:Platelet Aggregation Inhibitors