title: BioDoser: improved dose-estimation software for biological radiation dosimetry.
abstract: This paper introduces a software program that was developed with the aims to improve the efficiency and veracity of calibration curve fitting and data processing in radiation biological dosimetry and other biological experiments, and which is termed BioDoser. BioDoser uses least squares and loop testing of monotonicity method and algorithm of non-uniformed confidence interval. In addition, this program enables integration of multiple different biomarkers typically used in biological dosimetry. These include partial body exposure, minimum number of cells to be analyzed, G function correction modules that are helpful in dose estimation when using chromosome aberration frequencies, micronucleus rate, comet assay and other biological methods. The software is freely available at http://bit.ly/kKBSNR.
authors.affiliation: Department of Radiation Hazard Evaluation, Institute of Radiation Medicine of Chinese Academy of Medical Science & Peking Union Medical College, Tianjin 300192, China.
authors.forename: Hong
authors.initials: H
authors.lastname: Wang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Liu
authors.forename: Dandan
authors.initials: D
authors.lastname: Wan
authors.forename: Jian
authors.initials: J
authors.lastname: Xiang
authors.forename: Liqing
authors.initials: L
authors.lastname: Du
authors.forename: Yan
authors.initials: Y
authors.lastname: Wang
authors.forename: Jia
authors.initials: J
authors.lastname: Cao
authors.forename: Yue
authors.initials: Y
authors.lastname: Fu
authors.forename: Feiyue
authors.initials: F
authors.lastname: Fan
authors.forename: Markus
authors.initials: M
authors.lastname: Hecker
mesh_terms: D000465:Algorithms; D002138:Calibration; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D011874:Radiometry