title: Cyclocondensation of amino-propargyl silanes.
abstract: Amino-propargyl silanes condense with carbonyl compounds to form imines and subsequently cyclize to form allenylidene tetrahydroquinolines. The cyclocondensations are catalyzed by a variety of Brønsted acids, among which phosphoric acids provide the highest yields. Subsequent intramolecular and intermolecular additions to the allene moiety provide complex polycyclic amines.
authors.affiliation: Department of Biochemistry, UT Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9038, United States.
authors.forename: Yizhong
authors.initials: Y
authors.lastname: Wang
authors.forename: Joseph M
authors.initials: JM
authors.lastname: Ready
mesh_terms: D000588:Amines / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D007097:Imines / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D011804:Quinolines / Q000138:chemical synthesis* / Q000737:chemistry; D012821:Silanes / Q000737:chemistry*
chemical_list: D000588:Amines; D007097:Imines; D011804:Quinolines; D012821:Silanes; C542964:1,2,3,4-tetrahydroquinoline