title: Changes in Peak Flow value during immunotherapy administration.
abstract: Nasal allergies are prevalent affecting a large percentage of the population. Not only the upper respiratory tract but the whole body is involved. Allergies produce morbidity (and even occasional mortality) as they can lead to asthma development, and increased number of accidents. Immunotherapy results can be evaluated by following symptom scores, medication use, and objective measurements. Using a Peak Flow Meter (PFM) to evaluate immunotherapy results, it became evident that patients with and without asthma exhibited an improvement in the Peak Flow (PF) value, suggesting that lower airway involvement in allergic patients could be more prevalent than assumed. A consecutive chart review was performed including patients of any age with nasal allergies (with or without asthma) treated with immunotherapy for at least 6 months that had at least 2 complete evaluations. When immunotherapy was successful, most patients exhibited an increase in the PF value regardless of asthma status. A very significant finding was that most allergy sufferers may have lower airway inflammation. The use of the PF value to assess immunotherapy results and the potential failure to diagnose asthma in allergy sufferers are discussed. A better diagnosis of lower airway inflammation could be substantial in the management of these patients.
authors.affiliation: Associates in ENT & Allergy, PA 470 North Aveue, Elizabeth, NJ 07208, USA. saporta.allergy@gmail.com
authors.forename: Diego
authors.initials: D
authors.lastname: Saporta
mesh_terms: D000328:Adult; D000368:Aged; D000485:Allergens / Q000009:adverse effects / Q000276:immunology; D001249:Asthma / Q000503:physiopathology / Q000628:therapy*; D002675:Child, Preschool; D003888:Desensitization, Immunologic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010366:Peak Expiratory Flow Rate; D012129:Respiratory Function Tests / Q000379:methods*; D006255:Rhinitis, Allergic, Seasonal / Q000503:physiopathology / Q000628:therapy*; D025363:Rhinomanometry / Q000379:methods*; D011795:Surveys and Questionnaires; D055815:Young Adult
chemical_list: D000485:Allergens