title: Diagnostic value of anthropometric indices for initial stage of atherosclerosis in adult women.
abstract: Excess body weight is a cardiovascular risk factor. The relationship between anthropometric indices and cardiovascular health is not completely understood. Carotid Intima-Media Thickness (CIMT) is a subclinical marker of atherosclerosis. This study aimed to investigate the best anthropometric obesity indicator for diagnosis of initial stage of atherosclerosis by CIMT. This cross-sectional study included 100 adult women, aged 18-50 years. Anthropometric indices were measured with standard protocol and CIMT was measured by non-invasive ultrasound. Receiver Operating Characteristics (ROC) curve analysis was carried out to determine the optimal cut-off values of anthropometric indices, and the best indices for atherosclerosis diagnosis. On ROC curve analysis the suggested appropriate cut-offs of waist circumference (WC), waist to hip ratio (WHR), waist to height ratio (WHtR), body mass index (BMI) and percentage body fat (%BF) were 96 cm, 0.86, 0.64, 31.29 kg/m² and 30.42%, respectively. The area under the ROC curve of BMI (AUC=0.74, 95%CI=0.62-0.86) and WHtR (AUC=0.74, 95%CI=0.63-0.85) were greater than other anthropometric indices. The AUC for WHR was the lowest among the studied obesity indices AUC=0.68 (95% CI=0.54-0.81). In our study, WHtR and BMI were the best diagnostic parameters of initial stage of atherosclerosis while WHR was the worst based on AUC.
authors.affiliation: School of Health and Nutrition, Tabriz University of Medical sciences, Tabriz, Iran.
authors.forename: Motahar
authors.initials: M
authors.lastname: Heidari-Beni
authors.forename: Masoud
authors.initials: M
authors.lastname: Hajimaghsood
authors.forename: Mehrangiz
authors.initials: M
authors.lastname: Ebrahimi-Mamaghani
authors.forename: Mohammad Asghari
authors.initials: MA
authors.lastname: Jafarabadi
authors.forename: Seyed Mohammad Hosein
authors.initials: SM
authors.lastname: Mousavi-Jazayeri
authors.forename: Javad
authors.initials: J
authors.lastname: Mohtadinia
mesh_terms: D000293:Adolescent; D000328:Adult; D000465:Algorithms; D050197:Atherosclerosis / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D001827:Body Height; D015992:Body Mass Index; D001835:Body Weight; D001837:Body Weights and Measures; D059168:Carotid Intima-Media Thickness; D003430:Cross-Sectional Studies; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D007492:Iran / Q000453:epidemiology; D008875:Middle Aged; D050177:Overweight / Q000503:physiopathology*; D012306:Risk; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D055815:Young Adult