title: A copper-catalyzed Petasis reaction for the synthesis of tertiary amines and amino esters.
abstract: We have developed a copper-catalyzed process for the coupling of aldehydes, amines, and boronic acids. This allows greater reactivity with simple aryl boronic acids and allows coupling reactions to proceed that previously failed. Initial mechanistic studies support a process involving transmetalation from boron to copper.
authors.affiliation: School of Chemistry, Trinity Biomedical Sciences Institute, University of Dublin, Trinity College, Dublin 2, Ireland.
authors.forename: Robin
authors.initials: R
authors.lastname: Frauenlob
authors.forename: Carlos
authors.initials: C
authors.lastname: García
authors.forename: Gary A
authors.initials: GA
authors.lastname: Bradshaw
authors.forename: Helen M
authors.initials: HM
authors.lastname: Burke
authors.forename: Enda
authors.initials: E
authors.lastname: Bergin
mesh_terms: D000588:Amines / Q000737:chemistry*; D001897:Boronic Acids / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D004952:Esters; D015394:Molecular Structure
chemical_list: D000588:Amines; D001897:Boronic Acids; D004952:Esters; D003300:Copper