title: [Risk factors of cognitive impairment after off-pump coronary artery bypass grafting].
abstract: OBJECTIVE
  To analyze the risk factors of cognitive impairment after off-pump coronary artery bypass grafting (OPCABG).
  
  
  METHODS
  A total of 102 patients [male: 82, age: (65.7 ± 7.1) years] undergoing OPCABG in our hospital between January 2009 and December 2010 were divided into postoperative cognitive dysfunction (POCD) group and non-POCD group by the MMSE questionnaire survey conducted at 7 days pre- and post-operation respectively.
  
  
  RESULTS
  The incidence of POCD was 48.0% (49/102). Multivariate logistic stepwise regression analysis showed: advanced age (OR = 1.32, 95%CI: 1.10 - 1.46, P = 0.002), smoking (OR = 1.26, 95%CI: 1.18 - 1.32, P = 0.001), hypertension (OR = 1.66, 95%CI: 1.36 - 1.78, P = 0.023), diabetes (OR = 1.62, 95%CI: 1.02 - 2.84, P = 0.032), stroke (OR = 3.32, 95%CI: 1.68 - 6.49, P < 0.001), mitral regurgitation (OR = 1.48, 95%CI: 1.26 - 1.89, P < 0.001), and time of wall clamp (OR = 4.84, 95%CI: 1.08 - 7.28, P < 0.001) were independent risk factors of POCD.
  
  
  CONCLUSIONS
  Advanced age, smoking, hypertension, diabetes, stroke, mitral regurgitation, and prolonged time of wall clamp are major risk factors for POCD in patients undergoing OPCABG.
authors.affiliation: Department of Cardiac Surgery, First Affiliated Hospital of Xinxiang Medical College, Xinxiang, China. cqt3000@126.com
authors.forename: Qin-tao
authors.initials: QT
authors.lastname: Cui
authors.forename: Qing-lin
authors.initials: QL
authors.lastname: Fu
authors.forename: Pei-li
authors.initials: PL
authors.lastname: Han
authors.forename: Jie
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000368:Aged; D003072:Cognition Disorders / Q000209:etiology*; D047549:Coronary Artery Bypass, Off-Pump / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology*; D012307:Risk Factors; D016896:Treatment Outcome