title: Hippo pathway in intestinal homeostasis and tumorigenesis.
abstract: The Hippo pathway plays a crucial role in controlling organ size by inhibiting cell proliferation and promoting cell death. Recent findings implicate that this pathway is involved in the process of intestinal regeneration and tumorigenesis. Here we summarize current studies for the function of the Hippo signaling pathway in intestinal homeostasis, regeneration and tumorigenesis, and the crosstalk between the Hippo signaling pathway and other major signaling pathways, i.e. Wnt, Notch and Jak/Stat signaling pathways in intestinal compartment.
authors.affiliation: State Key Laboratory of Stress Cell Biology, School of Life Sciences, Xiamen University, Xiamen 361005, China. chenlanfen@xmu.edu.cn
authors.forename: Lanfen
authors.initials: L
authors.lastname: Chen
authors.forename: Funiu
authors.initials: F
authors.lastname: Qin
authors.forename: Xianming
authors.initials: X
authors.lastname: Deng
authors.forename: Joseph
authors.initials: J
authors.lastname: Avruch
authors.forename: Dawang
authors.initials: D
authors.lastname: Zhou
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic; D004330:Drosophila; D029721:Drosophila Proteins / Q000378:metabolism*; D006706:Homeostasis; D007413:Intestinal Mucosa / Q000378:metabolism*; D047908:Intracellular Signaling Peptides and Proteins / Q000378:metabolism*; D009687:Nuclear Proteins / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D012038:Regeneration; D015398:Signal Transduction; D000099317:Hippo Kinases
chemical_list: D029721:Drosophila Proteins; D047908:Intracellular Signaling Peptides and Proteins; D009687:Nuclear Proteins; D017346:Protein Serine-Threonine Kinases; C499474:hpo protein, Drosophila; D000099317:Hippo Kinases