title: Plasma lipid metabolites are associated with gestational age but not bronchopulmonary dysplasia.
abstract: OBJECTIVE
  To test the hypothesis that plasma lipid metabolite levels in premature infants are associated with the development of bronchopulmonary dysplasia (BPD). The studies also tested a secondary hypothesis that plasma lipid metabolite levels were correlated with gestational age.
  
  
  METHODS
  Infants born <32 weeks' gestation were enrolled during the first 72 h of life. Plasma samples were obtained and lipid levels were measured by LC-MS/MS. Clinical data were collected to determine infant outcomes and BPD diagnosis.
  
  
  RESULTS
  Following adjustment for confounders, lipid levels were not associated with BPD; however, levels of specific lipid metabolites were correlated with gestational age.
  
  
  CONCLUSIONS
  Immature lipid metabolism pathways in premature infants may contribute to the pathogenesis of BPD and other diseases.
authors.affiliation: Department of Pediatrics, Center for Perinatal Research, The Research Institute at Nationwide Children's Hospital, The Ohio State University, Columbus, OH, USA. lynette.rogers@nationwidechildrens.org
authors.forename: Lynette K
authors.initials: LK
authors.lastname: Rogers
authors.forename: Christine M
authors.initials: CM
authors.lastname: Young
authors.forename: Michael L
authors.initials: ML
authors.lastname: Pennell
authors.forename: Trent E
authors.initials: TE
authors.lastname: Tipple
authors.forename: Karen L
authors.initials: KL
authors.lastname: Leonhart
authors.forename: Stephen E
authors.initials: SE
authors.lastname: Welty
mesh_terms: D001997:Bronchopulmonary Dysplasia / Q000097:blood*; D002853:Chromatography, Liquid; D005231:Fatty Acids, Unsaturated / Q000097:blood*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D016014:Linear Models; D016015:Logistic Models; D008297:Male; D011446:Prospective Studies; D053719:Tandem Mass Spectrometry
chemical_list: D005231:Fatty Acids, Unsaturated