title: Aerosol-based fabrication of biocompatible organic-inorganic nanocomposites.
abstract: Several novel nanoparticle composites were conveniently obtained by appropriately reacting freshly produced aerosol metal nanoparticles with soluble organic components. A serial reactor consisting of a spark particle generator coupled to a collison atomizer was used to fabricate the new materials, which included nanomagnetosols (comprising iron nanoparticles, the drug ketoprofen, and a Eudragit shell), hybrid nanogels (comprising iron nanoparticles and an N-isopropylacrylamide, NIPAM, gel), and nanoinorganics (gold immobilized silica). A fourth hybrid material, consisting of iron-gold nanoparticles and NIPAM) was obtained via an aerosol into liquid configuration, in which aerosol iron-gold particles were collected into a NIPAM/ethanol solution and then formed into nanogels with NIPAM under ultrasonic treatment. The strategy outlined in this work is potentially generalizable as a new platform for creating biocompatible nanocomposites, using only clinically approved starting materials in a single pass and under low-temperature conditions.
authors.affiliation: Department of Chemistry, Purdue University, Indiana 47907, USA.
authors.forename: Jeong Hoon
authors.initials: JH
authors.lastname: Byeon
authors.forename: Jeffrey T
authors.initials: JT
authors.lastname: Roberts
mesh_terms: D000178:Acrylamides / Q000737:chemistry; D000336:Aerosols / Q000737:chemistry*; D001672:Biocompatible Materials / Q000737:chemistry* / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D000431:Ethanol / Q000737:chemistry; D005782:Gels / Q000737:chemistry; D006046:Gold / Q000737:chemistry; D057809:HEK293 Cells; D006801:Humans; D053761:Nanocomposites / Q000737:chemistry* / Q000633:toxicity; D012822:Silicon Dioxide / Q000737:chemistry; D013696:Temperature
chemical_list: D000178:Acrylamides; D000336:Aerosols; D001672:Biocompatible Materials; D005782:Gels; D000431:Ethanol; D006046:Gold; D012822:Silicon Dioxide; C067295:N-isopropylacrylamide