title: Time is of the essence: microRNAs and age-associated neurodegeneration.
abstract: Aging is a key risk factor in neurodegenerative disease; however, little is known about cellular pathways that mediate age-associated degeneration of the brain. The Bonini lab has identified a conserved microRNA, miR-34, that plays a neuroprotective role in the aging Drosophila brain and suggests that it functions in temporal control of gene expression.
authors.affiliation: Institute of Molecular and Cell Biology, 61 Biopolis Dr., Singapore 138673.
authors.forename: Sherry
authors.initials: S
authors.lastname: Aw
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Cohen
mesh_terms: D000375:Aging; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D001921:Brain / Q000378:metabolism / Q000473:pathology*; D016922:Cellular Senescence; D004330:Drosophila / Q000235:genetics / Q000378:metabolism*; D029721:Drosophila Proteins / Q000235:genetics / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D019636:Neurodegenerative Diseases / Q000235:genetics / Q000378:metabolism*; D012307:Risk Factors; D013997:Time Factors; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D029721:Drosophila Proteins; C060408:Eip74EF protein, Drosophila; C570893:MIRN34 microRNA, Drosophila; D035683:MicroRNAs; D014157:Transcription Factors