title: The Suzuki reaction applied to the synthesis of novel pyrrolyl and thiophenyl indazoles.
abstract: The paper describes the Suzuki cross-coupling of a variety of N and C-3 substituted 5-bromoindazoles with N-Boc-2-pyrrole and 2-thiopheneboronic acids. The reactions, performed in the presence of K(2)CO(3), dimethoxyethane and Pd(dppf)Cl(2) as catalyst, gave the corresponding adducts in good yields. The methodology allows the facile production of indazole-based heteroaryl compounds, a unique architectural motif that is ubiquitous in biologically active molecules.
authors.affiliation: Department of Chemistry, Sapienza University of Rome, P.le A. Moro 5, I-00185 Roma, Italy.
authors.forename: Antonella
authors.initials: A
authors.lastname: Migliorini
authors.forename: Chiara
authors.initials: C
authors.lastname: Oliviero
authors.forename: Tecla
authors.initials: T
authors.lastname: Gasperi
authors.forename: Maria Antonietta
authors.initials: MA
authors.lastname: Loreto
mesh_terms: D002384:Catalysis; D007191:Indazoles / Q000138:chemical synthesis* / Q000737:chemistry; D011758:Pyrroles / Q000737:chemistry*; D013876:Thiophenes / Q000737:chemistry*
chemical_list: D007191:Indazoles; D011758:Pyrroles; D013876:Thiophenes