title: Effects of various drug therapies on Kleine-Levin syndrome: a case report.
abstract: Kleine-Levin syndrome (KLS) is a rare sleep disorder, predominantly affecting adolescent males, which presents as recurrent episodes of hypersomnia, behavioral and cognitive disturbances, hyperphagia and sometimes hypersexuality (Lisk, "Kleine-Levin syndrome." Pract Neurol 2009;9:42-45). Modafinil has been reported to show an effect in shortening the duration of symptomatic periods, but does not affect the recurrence rate (Huang et al., "Kleine-Levin syndrome: current status." Med Clin N Am 2010;94:557-562). However, no single drug therapy has been consistently successful, despite various psychotropic agents, including lithium, anticonvulsants and antidepressants, having been systematically tried (Arnulf et al., "Kleine-Levin syndrome: a systematic study of 108 patients." Ann Neurol 2008;63:482-492). This study reports a male adolescent with KLS who received several courses of drug therapy, providing a chance to compare differential drug effects over time.
authors.affiliation: Department of Psychiatry, Mackay Memorial Hospital, Taipei 25160, Taiwan.
authors.forename: Chi-Chun
authors.initials: CC
authors.lastname: Yao
authors.forename: Ying
authors.initials: Y
authors.lastname: Lin
authors.forename: Hui-Ching
authors.initials: HC
authors.lastname: Liu
authors.forename: Chau-Shoun
authors.initials: CS
authors.lastname: Lee
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000927:Anticonvulsants / Q000627:therapeutic use; D018692:Antimanic Agents / Q000627:therapeutic use; D002220:Carbamazepine / Q000031:analogs & derivatives / Q000627:therapeutic use; D002540:Cerebral Cortex / Q000503:physiopathology; D004569:Electroencephalography; D006801:Humans; D017593:Kleine-Levin Syndrome / Q000188:drug therapy* / Q000503:physiopathology; D018020:Lithium Compounds / Q000627:therapeutic use; D008140:Lorazepam / Q000627:therapeutic use; D008297:Male; D000078330:Oxcarbazepine; D020551:Pulse Therapy, Drug; D014635:Valproic Acid / Q000627:therapeutic use
chemical_list: D000305:Adrenal Cortex Hormones; D000927:Anticonvulsants; D018692:Antimanic Agents; D018020:Lithium Compounds; D002220:Carbamazepine; D014635:Valproic Acid; D008140:Lorazepam; D000078330:Oxcarbazepine