title: Mycophenolate mofetil in the therapy of uveitic macular edema--long-term results.
abstract: OBJECTIVE
  To assess the long-term efficacy of mycophenolate mofetil (MMF) in uveitic cystoid macular edema (CMO).
  
  
  METHODS
  Thirty-eight uveitis patients with CMO treated with MMF with a follow-up of at least 5 years were analyzed. The patients were divided into two groups: group A, 24 patients with CMO that had occurred before initiation of MMF; group B, 14 patients who developed CMO for the first time during MMF.
  
  
  RESULTS
  In group A, a complete remission of CMO without recurrences was observed in 12 of 24 patients (50%, rate: 0.12/patient-year). In group B, CMO occurred in 7 patients (50%) despite standard dosage of MMF, and in 7 patients (50%) during MMF dose reduction.
  
  
  CONCLUSIONS
  The results show that MMF is not always sufficiently effective as a long-term treatment for uveitic macular edema. Moreover, in some uveitis patients MMF cannot prevent new development of CMO.
authors.affiliation: Centre for Ophthalmology, University of Tuebingen, Tuebingen, Germany. deshka.doycheva@med.uni-tuebingen.de
authors.forename: Deshka
authors.initials: D
authors.lastname: Doycheva
authors.forename: Manfred
authors.initials: M
authors.lastname: Zierhut
authors.forename: Gunnar
authors.initials: G
authors.lastname: Blumenstock
authors.forename: Nicole
authors.initials: N
authors.lastname: Stuebiger
authors.forename: Christoph
authors.initials: C
authors.lastname: Deuter
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D008269:Macular Edema / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009173:Mycophenolic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D012008:Recurrence; D016896:Treatment Outcome; D014605:Uveitis / Q000188:drug therapy*; D014792:Visual Acuity / Q000187:drug effects; D055815:Young Adult
chemical_list: D007166:Immunosuppressive Agents; D009173:Mycophenolic Acid