title: Exercise inhibits allergic lung inflammation.
abstract: Aerobic conditioning (AC) performed either during or after sensitization reduces allergic inflammation in mice; however, the effects of AC performed before and during allergic sensitization on airway inflammation are unknown. Mice were divided into Control, AC, OVA, and AC + OVA groups. Mice were trained in a treadmill followed by either ovalbumin (OVA) sensitization or saline administration. Peribronchial inflammation, OVA-specific IgE and IgG1 titers, the expression of Th1 and Th2 cytokines, and airway remodeling were evaluated, as well as the expression of Eotaxin, RANTES, ICAM-1, VCAM-1, TGF-β and VEGF. Aerobic conditioning performed before and during allergic sensitization displayed an inhibitory effect on the OVA-induced migration of eosinophils and lymphocytes to the airways, a reduction of IgE and IgG1 titers and an inhibition of the expression of Th2 cytokines. The AC + OVA group also demonstrated reduced expression of ICAM-1, VCAM-1, RANTES, TGF-β and VEGF, as well as decreased airway remodeling (p<0.05). The effects of AC before and during the sensitization process inhibit allergic airway inflammation and reduce the production of Th2 cytokines and allergen-specific IgE and IgG1.
authors.affiliation: Physical Therapy, University of São Paulo, Sao Paulo, Brazil.
authors.forename: A C D
authors.initials: AC
authors.lastname: Silva
authors.forename: R P
authors.initials: RP
authors.lastname: Vieira
authors.forename: M
authors.initials: M
authors.lastname: Nisiyama
authors.forename: A B G
authors.initials: AB
authors.lastname: Santos
authors.forename: A
authors.initials: A
authors.lastname: Perini
authors.forename: T
authors.initials: T
authors.lastname: Mauad
authors.forename: M
authors.initials: M
authors.lastname: Dolhnikoff
authors.forename: M A
authors.initials: MA
authors.lastname: Martins
authors.forename: C R
authors.initials: CR
authors.lastname: Carvalho
mesh_terms: D000818:Animals; D016207:Cytokines / Q000097:blood / Q000378:metabolism; D006967:Hypersensitivity / Q000517:prevention & control*; D007073:Immunoglobulin E / Q000378:metabolism; D007074:Immunoglobulin G / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000008:administration & dosage; D010805:Physical Conditioning, Animal / Q000502:physiology*; D011014:Pneumonia / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control*; D012965:Sodium Chloride / Q000008:administration & dosage
chemical_list: D016207:Cytokines; D007074:Immunoglobulin G; D007073:Immunoglobulin E; D012965:Sodium Chloride; D010047:Ovalbumin