title: Neovascularization in retinopathy of prematurity: opposing actions of neuronal factors GPR91 and semaphorins 3A.
abstract: Retinopathy of prematurity (ROP) is a major cause of severe visual deficits in children. This review focuses on the role of newly identified factors from retinal neurons, which through their opposing actions on vascular development contribute to ROP. These hypoxia-generated mediators include the Krebs cycle intermediate, succinate acting via GPR91, and the neuronal guidance molecule Semaphorin 3A.
  
  
  CONCLUSIONS
  Neuron-derived factors guide retinal vascularization and are major contributors to the pathogenesis of ROP.
authors.affiliation: Departments of Pediatrics, Ophthalmology, and Pharmacology, Centre Hospitalier Universitaire Ste-Justine Research Center, Montréal, QC, Canada.
authors.forename: Jean-Sébastien
authors.initials: JS
authors.lastname: Joyal
authors.forename: Samy
authors.initials: S
authors.lastname: Omri
authors.forename: Nicholas
authors.initials: N
authors.lastname: Sitaras
authors.forename: José-Carlos
authors.initials: JC
authors.lastname: Rivera
authors.forename: Przemyslaw
authors.initials: P
authors.lastname: Sapieha
authors.forename: Sylvain
authors.initials: S
authors.lastname: Chemtob
mesh_terms: D015415:Biomarkers / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D043562:Receptors, G-Protein-Coupled / Q000378:metabolism*; D015861:Retinal Neovascularization / Q000209:etiology / Q000378:metabolism*; D055351:Retinal Neurons / Q000378:metabolism; D012178:Retinopathy of Prematurity / Q000378:metabolism* / Q000473:pathology; D040121:Semaphorin-3A / Q000378:metabolism*
chemical_list: D015415:Biomarkers; D043562:Receptors, G-Protein-Coupled; C557078:SUCNR1 protein, human; D040121:Semaphorin-3A