title: Incidence of diabetes and serum adipokines in Catalonian men: the ADIPOCAT study.
abstract: OBJECTIVE
  To investigate the relationship of body mass index and serum adipokines with incidence of diabetes in men.
  
  
  METHODS
  Ten-year cohort study of a random population sample of 1011 men aged 35-69 years from the MONICA-Catalonia survey (1986-1988). WHO-MONICA protocol and the US Hispanic NHANES diabetes questionnaire were applied. Fasting serum glucose and lipids were measured by enzymatic methods, adipokines and insulin by Luminex xMAP technology,and hs-CRP by nephelometry in stored baseline samples (-80°C). Type2 diabetes was defined as fasting glucose ≥ 7.0 mmol/L or diagnosed diabetes. Incident diabetes was defined as absence of these criteria at baseline but presence at re-examination. Cox regression analysis was used.
  
  
  RESULTS
  Incidence of diabetes (n = 85) was 10.3/1000 person-years, increasing significantly with BMI but decreasing by quartiles of adiponectin. Incidence increased above median BMI and glucose (45.3/1000 person-years, OR = 19.97). Log-adiponectin associated with reduced risk of diabetes after multivariate adjustment (HR = 0.24, 95% CI 0.08-0.72), with significant modification of this effect by baseline glycaemia. C-reactive protein was not a significant factor. Leptin lost strength when adjusted for BMI.
  
  
  CONCLUSIONS
  In a population with relatively high diabetes incidence, BMI and glucose were strong risk factors, while adiponectin protected against diabetes, especially in men with high glycaemic level.
authors.affiliation: Institute of Health Studies, Barcelona 08005, Spain. susana.sans@uab.cat
authors.forename: Susana
authors.initials: S
authors.lastname: Sans
authors.forename: Teresa
authors.initials: T
authors.lastname: Padró
authors.forename: Jaakko
authors.initials: J
authors.lastname: Tuomilehto
authors.forename: Lina
authors.initials: L
authors.lastname: Badimon
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D001794:Blood Pressure; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000378:metabolism; D008076:Cholesterol, HDL / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D020738:Leptin / Q000097:blood; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016016:Proportional Hazards Models; D013030:Spain / Q000453:epidemiology; D011795:Surveys and Questionnaires; D014280:Triglycerides / Q000097:blood
chemical_list: D052242:Adiponectin; D001786:Blood Glucose; D008076:Cholesterol, HDL; D020738:Leptin; D014280:Triglycerides; D002097:C-Reactive Protein