title: A case report of simultaneous occurrence of Wilms tumor and acute lymphoblastic leukemia.
abstract: Acute lymphoblastic leukemia (ALL) is the most and Wilms tumor is the sixth most common malignancy in childhood. Genetic changes in WT1 or WT2 in Wilms tumor and a wide range of chromosomal mutations are reported in ALL that may predispose them to other congenital anomalies especially in Wilms tumor patients. Hospitalized patient was a 3-year-old girl with high-grade fever, petechia, and solid abdominal mass. The patient had anemia, thrombocytopenia, and leukocytosis in her initial homogram, and a large renal mass originated from left kidney in abdominal imagings. Bone marrow aspiration revealed ALL, and simultaneous kidney biopsy uncovered her Wilms tumor. Leukemia and Wilms tumor are 2 independent malignancies but occurred together in this patient. It is reasonable to investigate cellular and genetic relation of these 2 independent malignancies.
authors.affiliation: Pediatric Hematology/Oncology Department, Besat Hospital, Hamedan University of Medical Science, Hamedan, Iran. hesfehani@yahoo.com
authors.forename: Hossein
authors.initials: H
authors.lastname: Esfahani
authors.forename: Babak
authors.initials: B
authors.lastname: Abdolkarimi
authors.forename: Arash
authors.initials: A
authors.lastname: Dehghan
mesh_terms: D002675:Child, Preschool; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics / Q000473:pathology*; D025721:WT1 Proteins / Q000235:genetics; D009396:Wilms Tumor / Q000473:pathology*
chemical_list: D025721:WT1 Proteins