title: Weak estrogenic transcriptional activities of Bisphenol A and Bisphenol S.
abstract: In 2011, the European Commission has restricted the use of Bisphenol A in plastic infant feeding bottles. In a response to this restriction, Bisphenol S is now often used as a component of plastic substitutes for the production of babybottles. One of the major concerns leading to the restriction of Bisphenol A was its weak estrogenic activity. By using two highly standardised transactivation assays, we could demonstrate that the estrogenic activity of Bisphenol A and Bisphenol S is of a comparable potency. Furthermore, some insights about the structure-activity relationships of these two chemicals and their metabolites could be gained from in silico predictions of their relative estrogen receptor-binding affinities and their liver phase-I biotransformation.
authors.affiliation: European Commission, Joint Research Centre, Institute for Health and Consumer Protection, EURL ECVAM (European Union Reference Laboratory for Alternatives to Animal Testing), Via E. Fermi 2749, I-21027 Ispra (VA), Italy.
authors.forename: Elise
authors.initials: E
authors.lastname: Grignard
authors.forename: Silvia
authors.initials: S
authors.lastname: Lapenna
authors.forename: Susanne
authors.initials: S
authors.lastname: Bremer
mesh_terms: D001559:Benzhydryl Compounds; D001665:Binding Sites; D045744:Cell Line, Tumor; D003198:Computer Simulation; D052244:Endocrine Disruptors / Q000378:metabolism / Q000494:pharmacology*; D047628:Estrogen Receptor alpha / Q000378:metabolism; D004968:Estrogens, Non-Steroidal / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D010636:Phenols / Q000378:metabolism / Q000494:pharmacology*; D013450:Sulfones; D015533:Transcriptional Activation / Q000187:drug effects; D000098831:Bisphenol S Compounds; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D052244:Endocrine Disruptors; D047628:Estrogen Receptor alpha; D004968:Estrogens, Non-Steroidal; D010636:Phenols; D013450:Sulfones; C543008:bisphenol S; D000098831:Bisphenol S Compounds; C006780:bisphenol A; D000098826:Bisphenol A Compounds