title: [The association of target organ damage with abnormal ankle brachial index in hypertensive patients].
abstract: OBJECTIVE
  To investigate the association of hypertensive target organ damage with abnormal ankle brachial index (ABI) in high-risk hypertensive patients.
  
  
  METHODS
  During December 2008 to May 2009, a cross-sectional study was conducted to investigated the prevalence of abnormal ABI (ABI < 0.90) in 2674 community-dwelling, hypertensive patients, who aged > 40 years, without coronary heart disease, stroke/transient ischemic attack or known arteriosclerosis, from 18 centers in China. Data were acquired through history, physical examination, laboratory and other diagnostic tests.
  
  
  RESULTS
  There were 2615 subjects eligible for the full analysis set. The high-risk hypertensive patients with arterial wall thickening, arterial wall thickening and slightly elevated serum creatinine had a higher prevalence of abnormal ABI than their counterparts respectively (P < 0.05). Compared with the normal group, the abnormal ABI group had a higher serum creatinine level on average (P < 0.01). After adjustment for certain factors including investigation center, demographic factors, cardiovascular disease (CVD) risk and CVD risk factors using an unconditional logistic regression model, arterial wall thickening (OR 2.416, 95%CI 1.395 - 4.183, P = 0.0016) and slightly elevated serum creatinine (OR 3.377, 95%CI 1.267 - 8.997, P = 0.0149) were positively associated with abnormal ABI. However, arterial wall thickening (OR 0.988, 95%CI 0.576 - 1.695, P = 0.9664) and microalbuminuria (OR 1.389, 95%CI 0.685 - 2.817, P = 0.3621) were irrelevant to abnormal ABI.
  
  
  CONCLUSIONS
  So far as a high-risk hypertensive patient is concerned, there are significant statistical correlations between arterial wall thickening and/or slightly elevated serum creatinine and an abnormal ABI, but no significant statistical correlations between arterial wall thickening or microalbuminuria and an abnormal ABI is observed.
authors.affiliation: School of Public Health, Fudan University, Shanghai, China.
authors.forename: Yong
authors.initials: Y
authors.lastname: Mao
authors.forename: Jin-ming
authors.initials: JM
authors.lastname: Yu
authors.forename: Fen
authors.initials: F
authors.lastname: Zhang
authors.forename: Yi-qiang
authors.initials: YQ
authors.lastname: Zhan
authors.forename: Da-yi
authors.initials: DY
authors.lastname: Hu
authors.forename: Qing-wu
authors.initials: QW
authors.lastname: Jiang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D055109:Ankle Brachial Index; D001161:Arteriosclerosis / Q000473:pathology*; D002681:China / Q000453:epidemiology; D003327:Coronary Disease / Q000473:pathology*; D003401:Creatine / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000473:pathology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged
chemical_list: D003401:Creatine