title: Aging, atherosclerosis, and IGF-1.
abstract: Insulin-like growth factor 1 (IGF-1) is an endocrine and autocrine/paracrine growth factor that circulates at high levels in the plasma and is expressed in most cell types. IGF-1 has major effects on development, cell growth and differentiation, and tissue repair. Recent evidence indicates that IGF-1 reduces atherosclerosis burden and improves features of atherosclerotic plaque stability in animal models. Potential mechanisms for this atheroprotective effect include IGF-1-induced reduction in oxidative stress, cell apoptosis, proinflammatory signaling, and endothelial dysfunction. Aging is associated with increased vascular oxidative stress and vascular disease, suggesting that IGF-1 may exert salutary effects on vascular aging processes. In this review, we will provide a comprehensive update on IGF-1's ability to modulate vascular oxidative stress and to limit atherogenesis and the vascular complications of aging.
authors.affiliation: Tulane University Heart & Vascular Institute, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Higashi
authors.forename: Sergiy
authors.initials: S
authors.lastname: Sukhanov
authors.forename: Asif
authors.initials: A
authors.lastname: Anwar
authors.forename: Shaw-Yung
authors.initials: SY
authors.lastname: Shai
authors.forename: Patrice
authors.initials: P
authors.lastname: Delafontaine
mesh_terms: D000375:Aging / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology; D050197:Atherosclerosis / Q000188:drug therapy / Q000378:metabolism*; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000503:physiopathology; D007334:Insulin-Like Growth Factor I / Q000378:metabolism* / Q000494:pharmacology; D008136:Longevity / Q000187:drug effects / Q000502:physiology; D008297:Male; D051379:Mice; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology; D058226:Plaque, Atherosclerotic / Q000188:drug therapy / Q000378:metabolism; D051381:Rats
chemical_list: D007334:Insulin-Like Growth Factor I