title: Treatment of late syphilis with 2.4 million units benzathine penicillin G (BPG): tolerance of single versus divided doses.
abstract: Although there is no data in the literature, some textbooks recommend fractioning the injection of benzathine penicillin G (BPG) for alleviating the pain. In a monocentric study done in 50 consecutive patients with late syphilis. Patients were assigned to receive 1 dose of 2.4 million units BPG intramuscularly the first week and 2 doses of 1.2 million units BPG in each buttock the second week. In the third week, patients were asked to choose between the 2 options. It was demonstrated that the 2 techniques were equally well tolerated and equally preferred by patients.
authors.affiliation: Centre des MST, Hôpital St-Louis, AP-HP, Paris, France. michel.janier@sls.aphp.fr
authors.forename: Michel
authors.initials: M
authors.lastname: Janier
authors.forename: Eliane
authors.initials: E
authors.lastname: Libar
authors.forename: Annie
authors.initials: A
authors.lastname: Bonnet
authors.forename: Patrick
authors.initials: P
authors.lastname: Meunier
authors.forename: Magda
authors.initials: M
authors.lastname: Tabet
authors.forename: Monique
authors.initials: M
authors.lastname: Mathourais
authors.forename: Christine
authors.initials: C
authors.lastname: Paterour
authors.forename: Raphael
authors.initials: R
authors.lastname: Porcher
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D057240:Patient Preference / Q000706:statistics & numerical data*; D010401:Penicillin G Benzathine / Q000008:administration & dosage*; D010865:Pilot Projects; D013587:Syphilis / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D010401:Penicillin G Benzathine