title: Diagnosing vaginal infections through measurement of biogenic amines by ion mobility spectrometry.
abstract: OBJECTIVE
  To compare diagnosis of bacterial vaginosis according to the Amsel criteria with measurement by ion mobility spectrometry (IMS) of the biogenic amines that are present in vaginal discharge fluid.
  
  
  METHODS
  Duplicate samples of vaginal fluid were collected from 115 unselected and consecutive patients in a vaginitis clinic in Detroit. All samples were evaluated using Amsel criteria and the results were compared with the diagnosis based on the IMS results.
  
  
  RESULTS
  The incidence rate of vaginal infections was assessed on the basis of both tests and the frequency of BV was found to be 17.4%. The sensitivity and specificity for bacterial vaginosis diagnosis using IMS determination were 95.5% and 98.9%, respectively, with an accuracy of 94.4%.
  
  
  CONCLUSIONS
  The results show that IMS may be used to rapidly diagnose this common vaginal infection with high accuracy.
authors.affiliation: Harper University Hospital, Division of Infectious Diseases, Wayne State University School of Medicine, MI 48201, USA. jsobel@med.wayne.edu
authors.forename: Jack D
authors.initials: JD
authors.lastname: Sobel
authors.forename: Zeev
authors.initials: Z
authors.lastname: Karpas
authors.forename: Avraham
authors.initials: A
authors.lastname: Lorber
mesh_terms: D001679:Biogenic Amines / Q000032:analysis*; D002103:Cadaverine / Q000032:analysis; D005260:Female; D006801:Humans; D008744:Methylamines / Q000032:analysis; D011700:Putrescine / Q000032:analysis; D012680:Sensitivity and Specificity; D013057:Spectrum Analysis / Q000379:methods; D014247:Trichomonas Vaginitis / Q000175:diagnosis; D019522:Vaginal Discharge / Q000378:metabolism*; D016585:Vaginosis, Bacterial / Q000175:diagnosis* / Q000382:microbiology
chemical_list: D001679:Biogenic Amines; D008744:Methylamines; D002103:Cadaverine; C023336:trimethylamine; D011700:Putrescine