title: The spectrum of pulmonary malformation in trisomy-21 patient. A review with emphasis on the molecular-genetic basis.
abstract: Gene overexpression has been identified as a primary determining factor for the distinct Down syndrome (DS) phenotypes. Previous genetic research has identified a spectrum of gene expressions responsible for many of the observed traits in DS patients including cardiovascular, brain, and GI anomalies. However, the molecular/genetic basis underlying pulmonary anomalies are yet to be identified, even though respiratory complications represent the leading cause of morbidity and mortality in DS patients. In this article, we will discuss the Etiopathogenesis and spectrum of pulmonary anomalies in DS patients.
authors.affiliation: Department of Pathology, Children’s Healthcare of Atlanta, Atlanta, Georgia 30322, USA.
authors.forename: Mark
authors.initials: M
authors.lastname: Salinas
authors.forename: Nancy
authors.initials: N
authors.lastname: Elawabdeh
authors.forename: Jenny
authors.initials: J
authors.lastname: Lin
authors.forename: Mina M
authors.initials: MM
authors.lastname: Naguib
authors.forename: Melissa G
authors.initials: MG
authors.lastname: Hodge
authors.forename: Bahig M
authors.initials: BM
authors.lastname: Shehata
mesh_terms: D004314:Down Syndrome / Q000150:complications* / Q000473:pathology*; D006801:Humans; D015619:Respiratory System Abnormalities / Q000235:genetics* / Q000473:pathology*