title: Posttraumatic headache.
abstract: OBJECTIVE
  Posttraumatic headache (PTH) is a commonly occurring and potentially disabling consequence of concussion and mild traumatic brain injury (mTBI). This brief review highlights recent advances in the epidemiology, evaluation, and management of concussion, mTBI, and PTH.
  
  
  RESULTS
  Current epidemiological studies suggest that previous estimates of concussion and mTBI incidence are grossly underestimated and have also helped to identify specific activities and demographic groups that might be more susceptible. Concussion results in profound metabolic derangements during which the brain is potentially vulnerable to repeat injury and permanent damage. Imaging studies such as magnetic resonance (MR) spectroscopy and diffusion tensor imaging have proven to be effective at identifying these abnormalities both acutely and also weeks after symptoms resolution. To date, there have been no randomized, placebo-controlled studies supporting the efficacy of any treatment for PTH and current therapeutic decisions are guided only by expert opinion and current evidence-based guidelines for the treatment of specific primary headache phenotypes, the most commonly occurring of which is migraine.
  
  
  CONCLUSIONS
  Despite numerous advances in the awareness, pathophysiology, and diagnostic workup of concussion, mTBI, and PTH, there is a paucity of evidence-based guidance regarding treatment.
authors.affiliation: Mayo Clinic Arizona, Phoenix, Arizona, USA. vargas.bert@mayo.edu
authors.forename: Bert B
authors.initials: BB
authors.lastname: Vargas
authors.forename: David W
authors.initials: DW
authors.lastname: Dodick
mesh_terms: D001924:Brain Concussion / Q000150:complications* / Q000453:epidemiology; D001930:Brain Injuries / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology / Q000628:therapy; D005260:Female; D006261:Headache / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology* / Q000628:therapy; D006801:Humans; D008297:Male; D008659:Metabolic Diseases / Q000209:etiology; D012737:Sex Factors