title: Impact of asymptomatic Herpes simplex virus-2 infection on T cell phenotype and function in the foreskin.
abstract: Herpes simplex virus type 2 (HSV-2) increases the risk of HIV acquisition in men and overall CD4 T cell density in the foreskin. Using tissues obtained during routine male circumcision, we examined the impact of HSV-2 on the function and phenotype of foreskin T cells in Ugandan men. HSV-2 infection was predominantly associated with a compartmentalized increase in CCR5 expression by foreskin CD4 T cells, which may contribute to HIV susceptibility.
authors.affiliation: Clinical Science Division, Department of Medicine, University of Toronto, Toronto, Canada. Jessica.prodger@utoronto.ca
authors.forename: Jessica L
authors.initials: JL
authors.lastname: Prodger
authors.forename: Ronald
authors.initials: R
authors.lastname: Gray
authors.forename: Godfrey
authors.initials: G
authors.lastname: Kigozi
authors.forename: Fred
authors.initials: F
authors.lastname: Nalugoda
authors.forename: Ronald
authors.initials: R
authors.lastname: Galiwango
authors.forename: Kighoma
authors.initials: K
authors.lastname: Nehemiah
authors.forename: Moses
authors.initials: M
authors.lastname: Kakanga
authors.forename: Taha
authors.initials: T
authors.lastname: Hirbod
authors.forename: Maria J
authors.initials: MJ
authors.lastname: Wawer
authors.forename: Nelson
authors.initials: N
authors.lastname: Sewankambo
authors.forename: David
authors.initials: D
authors.lastname: Serwadda
authors.forename: Rupert
authors.initials: R
authors.lastname: Kaul
mesh_terms: D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000821:virology*; D002944:Circumcision, Male; D052816:Foreskin / Q000821:virology*; D018258:Herpesvirus 2, Human / Q000276:immunology*; D006801:Humans; D008297:Male; D019713:Receptors, CCR5 / Q000378:metabolism; D019562:Viral Load
chemical_list: D019713:Receptors, CCR5