title: Biosynthetically intriguing chlorinated lipophilic metabolites from geographically distant tropical marine cyanobacteria.
abstract: Five new vinylchlorine-containing metabolites, the lipoamides janthielamide A and kimbeamides A-C and the ketide-extended pyranone kimbelactone A, have been isolated from collections of marine cyanobacteria made in Curaçao and Papua New Guinea. Both janthielamide A and kimbeamide A exhibited moderate sodium channel blocking activity in murine Neuro-2a cells. Consistent with this activity, janthielamide A was also found to antagonize veratridine-induced sodium influx in murine cerebrocortical neurons. These lipoamides represent the newest additions to a relatively rare family of marine cyanobacterial-derived lipoamides and a new structural class of compounds exhibiting neuromodulatory activities from marine cyanobacteria.
authors.affiliation: Center for Marine Biotechnology and Biomedicine, Scripps Institution of Oceanography and Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California at San Diego, La Jolla, California 92093, USA.
authors.forename: Joshawna K
authors.initials: JK
authors.lastname: Nunnery
authors.forename: Niclas
authors.initials: N
authors.lastname: Engene
authors.forename: Tara
authors.initials: T
authors.lastname: Byrum
authors.forename: Zhengyu
authors.initials: Z
authors.lastname: Cao
authors.forename: Sairam V
authors.initials: SV
authors.lastname: Jabba
authors.forename: Alban R
authors.initials: AR
authors.lastname: Pereira
authors.forename: Teatulohi
authors.initials: T
authors.lastname: Matainaho
authors.forename: Thomas F
authors.initials: TF
authors.lastname: Murray
authors.forename: William H
authors.initials: WH
authors.lastname: Gerwick
mesh_terms: D000818:Animals; D002460:Cell Line; D000458:Cyanobacteria / Q000737:chemistry* / Q000378:metabolism; D005843:Geography; D054879:Halogenation; D051379:Mice; D015394:Molecular Structure; D018377:Neurotransmitter Agents / Q000737:chemistry* / Q000378:metabolism*; D019906:Nuclear Magnetic Resonance, Biomolecular; D008063:Thioctic Acid / Q000032:analysis / Q000737:chemistry; D014753:Vinyl Compounds / Q000737:chemistry*
chemical_list: D018377:Neurotransmitter Agents; D014753:Vinyl Compounds; D008063:Thioctic Acid