title: Macronutrient choice of BTBR.NZW mice congenic for a 21-gene region of chromosome 17.
abstract: There has been scant work to investigate the mechanisms influencing macronutrient selection by mice. Here, we measured the consumption and choice of carbohydrate- and fat-containing diets by NZW/LacJ (NZW) and BTBR/T+ tf/J (BTBR) strains. We found that NZW mice voluntarily ate more carbohydrate and less fat than did BTBR mice. Mice with a BTBR background and a heterozygous (BTBR/NZW) congenic region on chromosome 17 between 25.7 and 27.5 Mb (N10 generation) or 26.7 and 27.5 Mb (N12 generation) also ate more carbohydrate and less fat than did homozygous (BTBR/BTBR) littermate controls. Of the 21 known and predicted genes in the congenic interval between 26.7 and 27.5 Mb, we raise for consideration as a causative candidate Itpr3, the inositol triphosphate receptor type 3 gene, which is a component of the GPCR-mediated taste transduction cascade. We speculate that a mutation in Itpr3 influences food choice by impairing the detection of nutrients in the macronutrient-containing diets.
authors.affiliation: Monell Chemical Senses Center, Philadelphia, PA 19104-3308, USA. tordoff@monell.org
authors.forename: Michael G
authors.initials: MG
authors.lastname: Tordoff
authors.forename: Samira A
authors.initials: SA
authors.lastname: Jaji
authors.forename: Jacob M
authors.initials: JM
authors.lastname: Marks
authors.forename: Hillary T
authors.initials: HT
authors.lastname: Ellis
mesh_terms: D000818:Animals; D020296:Animals, Congenic; D001835:Body Weight / Q000502:physiology; D002755:Choice Behavior / Q000502:physiology*; D033481:Chromosomes, Mammalian / Q000235:genetics*; D003627:Data Interpretation, Statistical; D004032:Diet; D004435:Eating / Q000502:physiology; D005247:Feeding Behavior / Q000502:physiology*; D005260:Female; D005518:Food Preferences / Q000502:physiology*; D053496:Inositol 1,4,5-Trisphosphate Receptors / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D013649:Taste / Q000235:genetics / Q000502:physiology; D015430:Weight Gain / Q000502:physiology
chemical_list: D053496:Inositol 1,4,5-Trisphosphate Receptors