title: Reactive Oxygen Species Modulation of Na/K-ATPase Regulates Fibrosis and Renal Proximal Tubular Sodium Handling.
abstract: The Na/K-ATPase is the primary force regulating renal sodium handling and plays a key role in both ion homeostasis and blood pressure regulation. Recently, cardiotonic steroids (CTS)-mediated Na/K-ATPase signaling has been shown to regulate fibrosis, renal proximal tubule (RPT) sodium reabsorption, and experimental Dahl salt-sensitive hypertension in response to a high-salt diet. Reactive oxygen species (ROS) are an important modulator of nephron ion transport. As there is limited knowledge regarding the role of ROS-mediated fibrosis and RPT sodium reabsorption through the Na/K-ATPase, the focus of this review is to examine the possible role of ROS in the regulation of Na/K-ATPase activity, its signaling, fibrosis, and RPT sodium reabsorption.
authors.affiliation: Department of Medicine, College of Medicine University of Toledo, 3000 Arlington Avenue, Toledo, OH 43614, USA.
authors.forename: Jiang
authors.initials: J
authors.lastname: Liu
authors.forename: David J
authors.initials: DJ
authors.lastname: Kennedy
authors.forename: Yanling
authors.initials: Y
authors.lastname: Yan
authors.forename: Joseph I
authors.initials: JI
authors.lastname: Shapiro