title: Association of ADIPOR1 polymorphisms with bone mineral density in postmenopausal Korean women.
abstract: Adiponectin may affect bone through interactions with two known receptors, adiponectin receptors (ADIPOR) 1 and 2. We examined the association between polymorphisms of ADIPOR1 and ADIPOR2 and bone mineral density (BMD) in postmenopausal Korean women. Six polymorphisms in ADIPOR1 and four polymorphisms in ADIPOR2 were selected and genotyped in all study participants (n = 1,329). BMD at the lumbar spine and femur neck were measured using dual-energy X-ray absorptiometry. Lateral thoracolumbar (T4-L4) radiographs were obtained for vertebral fracture assessment and the occurrence of non-vertebral fractures examined using self-reported data. P values were adjusted for multiple testing using Bonferroni correction (P(corr)). ADIPOR1 rs16850799 and rs34010966 polymorphisms were significantly associated with femur neck BMD (P(corr) = 0.036 in the dominant model; P(corr) = 0.024 and P(corr) = 0.006 in the additive and dominant models, respectively). Subjects with the rare allele of each polymorphism had lower BMD, and association of rs34010966 with BMD showed a gene dosage effect. However, ADIPOR2 single nucleotide polymorphisms and haplotypes were not associated with BMD at any site. Our results suggest that ADIPOR1 polymorphisms present a useful genetic marker for BMD in postmenopausal Korean women.
authors.affiliation: Division of Endocrinology and Metabolism, Sanbon Medical Center, University of Wonkwang College of Medicine, Iksan, Korea.
authors.forename: Ha Young
authors.initials: HY
authors.lastname: Kim
authors.forename: Joo-Yeon
authors.initials: JY
authors.lastname: Hwang
authors.forename: Bok-Ghee
authors.initials: BG
authors.lastname: Han
authors.forename: Jong-Young
authors.initials: JY
authors.lastname: Lee
authors.forename: Eui Kyun
authors.initials: EK
authors.lastname: Park
authors.forename: Beom-Jun
authors.initials: BJ
authors.lastname: Kim
authors.forename: Seung Hun
authors.initials: SH
authors.lastname: Lee
authors.forename: Ghi Su
authors.initials: GS
authors.lastname: Kim
authors.forename: Shin-Yoon
authors.initials: SY
authors.lastname: Kim
authors.forename: Jung-Min
authors.initials: JM
authors.lastname: Koh
mesh_terms: D001483:Base Sequence; D015519:Bone Density / Q000235:genetics*; D005260:Female; D005272:Femur Neck / Q000502:physiology; D056726:Genetic Association Studies; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015663:Osteoporosis, Postmenopausal / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D017698:Postmenopause; D054419:Receptors, Adiponectin / Q000235:genetics*; D056910:Republic of Korea; D017422:Sequence Analysis, DNA
chemical_list: C475418:ADIPOR1 protein, human; C475420:ADIPOR2 protein, human; D005819:Genetic Markers; D054419:Receptors, Adiponectin