title: The solute carrier 6 family of transporters.
abstract: The solute carrier 6 (SLC6) family of the human genome comprises transporters for neurotransmitters, amino acids, osmolytes and energy metabolites. Members of this family play critical roles in neurotransmission, cellular and whole body homeostasis. Malfunction or altered expression of these transporters is associated with a variety of diseases. Pharmacological inhibition of the neurotransmitter transporters in this family is an important strategy in the management of neurological and psychiatric disorders. This review provides an overview of the biochemical and pharmacological properties of the SLC6 family transporters.
authors.affiliation: Research School of Biology, Australian National University, Canberra, ACT, Australia. Stefan.broer@anu.edu.au
authors.forename: Stefan
authors.initials: S
authors.lastname: Bröer
authors.forename: Ulrik
authors.initials: U
authors.lastname: Gether
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001692:Biological Transport / Q000502:physiology; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D026901:Membrane Transport Proteins / Q000737:chemistry / Q000145:classification* / Q000235:genetics / Q000378:metabolism*; D018377:Neurotransmitter Agents / Q000378:metabolism; D011487:Protein Conformation
chemical_list: D026901:Membrane Transport Proteins; D018377:Neurotransmitter Agents