title: Facilitative functionalization of cyanine dye by an on-off-on fluorescent switch for imaging of H2O2 oxidative stress and thiols reducing repair in cells and tissues.
abstract: We presented the design, synthesis, spectroscopy, and biological applications of DA-Cy, an on-off-on fluorescent probe to monitor H(2)O(2) oxidative stress and thiols reducing repair in living cells and tissues simply and directly.
authors.affiliation: School of Chemical Engineering, Dalian University of Technology, Dalian, PR China. yufabiao@163.com
authors.forename: Fabiao
authors.initials: F
authors.lastname: Yu
authors.forename: Peng
authors.initials: P
authors.lastname: Li
authors.forename: Ping
authors.initials: P
authors.lastname: Song
authors.forename: Bingshuai
authors.initials: B
authors.lastname: Wang
authors.forename: Jianzhang
authors.initials: J
authors.lastname: Zhao
authors.forename: Keli
authors.initials: K
authors.lastname: Han
mesh_terms: D000818:Animals; D002232:Carbocyanines / Q000138:chemical synthesis / Q000737:chemistry*; D002460:Cell Line; D004298:Dopamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry; D005456:Fluorescent Dyes / Q000138:chemical synthesis / Q000737:chemistry*; D006624:Hippocampus / Q000737:chemistry* / Q000648:ultrastructure; D006801:Humans; D006861:Hydrogen Peroxide / Q000032:analysis*; D008099:Liver / Q000166:cytology*; D008856:Microscopy, Fluorescence; D018384:Oxidative Stress; D051381:Rats; D013050:Spectrometry, Fluorescence; D013438:Sulfhydryl Compounds / Q000737:chemistry
chemical_list: D002232:Carbocyanines; D005456:Fluorescent Dyes; D013438:Sulfhydryl Compounds; C574569:dopamine-heptamethine cyanine dye; D006861:Hydrogen Peroxide; D004298:Dopamine