title: Effects of Panax notoginseng (Chinese ginseng) and acute exercise on postprandial glycemia in non-diabetic adults.
abstract: The purpose of this study is to determine whether Panax Notoginseng (PNG) taken for 3 days and one 30-min cycling exercise can reduce postprandial hyperglycemia after ingesting a 75-mg oral glucose solution (OGTT) in untrained non-diabetic men, age 20-45 years. We randomly assigned 52 men to: 1) ginseng (G) + exercise (G+Ex, n=14), 2) ginseng (G, n=13), 3) placebo (C) + exercise (C+Ex, n=12), and 4) placebo control groups (C, n=13). The G and C groups took a daily 3g dose of PNG and cornstarch-placebo supplement for 3 days, respectively. The exercise groups also performed a 30-min cycling exercise on day 3 prior to OGTT. The daily 3g-dose of PNG supplementation significantly lowered postprandial plasma glucose (PG) concentration at 30 min post-OGTT in the G group, compared with C (mean Δ±SE: G vs. C = 26.3±11 mg/dl, p<0.05) and PG area under the curve (PG-AUC0-90) in the G and G+Ex groups, relative to the C (G vs. C = 96.5±42 and G+Ex vs. C = 85.2±41 mg/dl, both p<0.05). We conclude that a daily 3g-dose of PNG taken for 3 days, not one acute bout of 30-min cycling exercise at 60% VO2max, lowered postprandial glycemia at 30-min post-OGTT and PG-AUC 0-90 min in non-diabetic men, age 20-45 years.
authors.affiliation: California State Polytechnic University, CA, USA.
authors.forename: Michael T C
authors.initials: MT
authors.lastname: Liang
authors.forename: W Y Jamie
authors.initials: WY
authors.lastname: Lau
authors.forename: Bulent
authors.initials: B
authors.lastname: Sokmen
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Spalding
authors.forename: William J
authors.initials: WJ
authors.lastname: Chuang
mesh_terms: D000328:Adult; D001642:Bicycling; D001786:Blood Glucose / Q000187:drug effects*; D004311:Double-Blind Method; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005080:Exercise Test; D006801:Humans; D006943:Hyperglycemia / Q000517:prevention & control*; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; D007004:Hypoglycemic Agents; D007328:Insulin; C519374:Panax notoginseng extract