title: Artificial electron carriers for photoenzymatic synthesis under visible light.
abstract: NAD analogues can be employed as artificial electron carriers for photoenzymatic synthesis under visible light. Four different NAD analogues that have a 3-substituted pyridine ring have been investigated. 3-Acetylpyridine adenine dinucleotide and 3-pyridinealdehyde adenine dinucleotide were photochemically reduced much more efficiently than NAD, while their reduced products showed coenzyme activity comparable to natural NAD.
authors.affiliation: KAIST Institute for the BioCentury, Department of Materials Science and Engineering, Daejeon, Republic of Korea.
authors.forename: Sahng Ha
authors.initials: SH
authors.lastname: Lee
authors.forename: Hye Jung
authors.initials: HJ
authors.lastname: Lee
authors.forename: Keehoon
authors.initials: K
authors.lastname: Won
authors.forename: Chan Beum
authors.initials: CB
authors.lastname: Park
mesh_terms: D003067:Coenzymes / Q000737:chemistry / Q000378:metabolism; D004583:Electrons; D008027:Light; D009243:NAD / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism; D010084:Oxidation-Reduction
chemical_list: D003067:Coenzymes; D009243:NAD; C009831:3-pyridinealdehyde-NAD; C005941:3-acetylpyridine adenine dinucleotide