title: A case of systemic amyloidosis beginning with purpura.
abstract: Primary systemic amyloidosis is a relatively rare disease, caused when abnormal extracellular deposition of fibrillary protein builds up in a variety of target organs, such as heart, kidneys, lungs liver, and so forth. The symptoms of the disease are usually vague, while many kinds of auxiliary or laboratory examinations especially pathologic biopsy can provide a clue for the diagnosis. Here we described a case who had purpura-like lesions in the initial stage, followed by progressive malfunctions in the kidneys, the heart, the lungs, as well as the liver. The final diagnosis was primary systemic amyloidosis determined by skin pathologic biopsy. And the disease led to a fatal outcome within three months after the diagnosis.
authors.affiliation: Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.
authors.forename: Jun-Ying
authors.initials: JY
authors.lastname: Zhao
authors.forename: Rui-Na
authors.initials: RN
authors.lastname: Zhang
authors.forename: Xiao-Han
authors.initials: XH
authors.lastname: Duan
authors.forename: Zhi-Li
authors.initials: ZL
authors.lastname: Xu
authors.forename: Hong-Wei
authors.initials: HW
authors.lastname: Li
authors.forename: Fu-Sheng
authors.initials: FS
authors.lastname: Gu
mesh_terms: D000686:Amyloidosis / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008875:Middle Aged; D011693:Purpura / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology*; D014463:Ultrasonography