title: Social deficits in male children and adolescents with sex chromosome aneuploidy: a comparison of XXY, XYY, and XXYY syndromes.
abstract: We compare social skills in three groups of males with sex chromosome aneuploidies (SCAs) using the Social Responsiveness Scale (SRS). Participants included males with XXY (N=102, M=10.08 years), XYY (N=40, M=9.93 years), and XXYY (N=32, M=11.57 years). XXY had lower (better) SRS scores compared to XYY and XXYY. Scores were not significantly different between XYY and XXYY. In all groups, there were significantly more with SRS scores in the severe range compared to the SRS normative sample. All groups scored lowest (better) on Social Motivation. Relationships between SRS scores and demographic and clinical variables were examined. Results describe the social skills in males with SCA, and suggest that an additional Y chromosome may contribute to increased risk of autistic behaviors.
authors.affiliation: University of Colorado School of Medicine -- Department of Pediatrics 13123 East 16th Ave, B140 Aurora, CO 80045, USA. Lisa.Cordeiro@childrenscolorado.org
authors.forename: Lisa
authors.initials: L
authors.lastname: Cordeiro
authors.forename: Nicole
authors.initials: N
authors.lastname: Tartaglia
authors.forename: David
authors.initials: D
authors.lastname: Roeltgen
authors.forename: Judith
authors.initials: J
authors.lastname: Ross
mesh_terms: D000293:Adolescent; D000294:Adolescent Behavior; D000782:Aneuploidy; D002648:Child; D002652:Child Behavior; D002653:Child Behavior Disorders / Q000235:genetics* / Q000523:psychology; D002659:Child Development Disorders, Pervasive / Q000235:genetics / Q000523:psychology; D002675:Child, Preschool; D003071:Cognition / Q000502:physiology; D006801:Humans; D007713:Klinefelter Syndrome / Q000235:genetics / Q000523:psychology*; D008297:Male; D010641:Phenotype; D025064:Sex Chromosome Disorders / Q000235:genetics / Q000523:psychology*; D012919:Social Behavior; D014997:XYY Karyotype / Q000235:genetics / Q000523:psychology*