title: Fertility preservation in girls.
abstract: Children that undergo treatment for cancer are at risk of suffering from subfertility or hormonal dysfunction due to the detrimental effects of radiotherapy and chemotherapeutic agents on the gonads. Cryopreservation of ovarian tissue prior to treatment offers the possibility of restoring gonadal function after resumption of therapy. Effective counseling and management of pediatric patients is crucial for preserving their future reproductive potential. The purpose of this article is to review recent literature and to revise recommendations we made in a 2007 article. Pediatric hemato-oncology, reproductive endocrinology, surgery, anesthesia and bioethics perspectives are discussed and integrated to propose guidelines for offering ovarian cryopreservation to premenarcheal girls with cancer.
authors.affiliation: Department of Obstetrics and Gynecology, Hadassah-Hebrew University Medical Center, 91120 Jerusalem, Israel.
authors.forename: Jennia
authors.initials: J
authors.lastname: Michaeli
authors.forename: Michael
authors.initials: M
authors.lastname: Weintraub
authors.forename: Eitan
authors.initials: E
authors.lastname: Gross
authors.forename: Yehuda
authors.initials: Y
authors.lastname: Ginosar
authors.forename: Vardit
authors.initials: V
authors.lastname: Ravitsky
authors.forename: Einat
authors.initials: E
authors.lastname: Eizenman
authors.forename: Eduardo
authors.initials: E
authors.lastname: Mitrani
authors.forename: Meital
authors.initials: M
authors.lastname: Lebovich
authors.forename: Neri
authors.initials: N
authors.lastname: Laufer
authors.forename: Stephen
authors.initials: S
authors.lastname: Kennedy
authors.forename: Ariel
authors.initials: A
authors.lastname: Revel