title: Matrix metalloproteinases in acute coronary syndromes: current perspectives.
abstract: Matrix metalloproteinases (MMPs) are a family of zinc metallo-endopeptidases secreted by cells and are responsible for much of the turnover of matrix components. Several studies have shown that MMPs are involved in all stages of the atherosclerotic process, from the initial lesion to plaque rupture. Recent evidence suggests that MMP activity may facilitate atherosclerosis, plaque destabilization, and platelet aggregation. In the heart, matrix metalloproteinases participate in vascular remodeling, plaque instability, and ventricular remodelling after cardiac injury. The aim of the present article is to review the structure, function, regulation of MMPs and to discuss their potential role in the pathogenesis of acute coronary syndromes, as well as their contribution and usefullness in the setting of the disease.
authors.affiliation: 1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece. kampoliannamaria@yahoo.gr.
authors.forename: Anna-Maria
authors.initials: AM
authors.lastname: Kampoli
authors.forename: Dimitris
authors.initials: D
authors.lastname: Tousoulis
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Papageorgiou
authors.forename: Charalambos
authors.initials: C
authors.lastname: Antoniades
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Androulakis
authors.forename: Eleftherios
authors.initials: E
authors.lastname: Tsiamis
authors.forename: George
authors.initials: G
authors.lastname: Latsios
authors.forename: Christodoulos
authors.initials: C
authors.lastname: Stefanadis
mesh_terms: D054058:Acute Coronary Syndrome / Q000201:enzymology* / Q000378:metabolism; D000818:Animals; D050197:Atherosclerosis / Q000503:physiopathology; D006801:Humans; D020782:Matrix Metalloproteinases / Q000378:metabolism*; D058226:Plaque, Atherosclerotic / Q000201:enzymology / Q000378:metabolism; D010974:Platelet Aggregation; D020257:Ventricular Remodeling
chemical_list: D020782:Matrix Metalloproteinases