title: Domestic use of cleaning sprays and asthma activity in females.
abstract: We aimed to study the associations between the household use of cleaning sprays and asthma symptoms and control of asthma, in females from the Epidemiological Study on the Genetics and Environment of Asthma (EGEA). Data were available for 683 females (mean age 44 yrs, 55% never smokers, 439 without asthma and 244 with current asthma). Both domestic exposures and asthma phenotypes (asthma symptom score, current asthma, poorly-controlled asthma (56%)) were evaluated as previously described in the European Community Respiratory Health Survey. Associations between the use of sprays and asthma phenotypes were evaluated using logistic and nominal regressions, adjusted for age, smoking, body mass index and occupational exposures. Significant associations were observed between the weekly use of at least two types of sprays and a high asthma symptom score (OR (95% CI) 2.50 (1.54-4.03)) compared with a null score. Consistent results were observed for current asthma (1.67 (1.08-2.56)) and poorly-controlled asthma (2.05 (1.25-3.35)) compared with females without asthma. The association for current asthma was higher in females not reporting avoidance of polluted places (2.12 (1.27-3.54)) than in those reporting such avoidance (0.99 (0.53-1.85)). The common use of household cleaning sprays is positively associated with a high asthma symptom score, current asthma and poorly-controlled asthma in females.
authors.affiliation: INSERM, CESP Centre for Research in Epidemiology and Population Health, U1018, Respiratory and Environmental Epidemiology Team, Universite´ Paris Sud 11, UMRS1018, Villejuif, France. nicole.lemoual@inserm.fr
authors.forename: Nicole
authors.initials: N
authors.lastname: Le Moual
authors.forename: Raphaelle
authors.initials: R
authors.lastname: Varraso
authors.forename: Valérie
authors.initials: V
authors.lastname: Siroux
authors.forename: Orianne
authors.initials: O
authors.lastname: Dumas
authors.forename: Rachel
authors.initials: R
authors.lastname: Nadif
authors.forename: Isabelle
authors.initials: I
authors.lastname: Pin
authors.forename: Jan-Paul
authors.initials: JP
authors.lastname: Zock
authors.forename: Francine
authors.initials: F
authors.lastname: Kauffmann
mesh_terms: D000328:Adult; D001249:Asthma / Q000139:chemically induced* / Q000453:epidemiology; D015331:Cohort Studies; D003902:Detergents / Q000009:adverse effects; D004202:Disinfectants / Q000009:adverse effects; D005260:Female; D006306:Health Surveys; D006801:Humans; D007073:Immunoglobulin E / Q000378:metabolism; D008875:Middle Aged; D009784:Occupational Diseases; D016273:Occupational Exposure / Q000706:statistics & numerical data; D016017:Odds Ratio; D010641:Phenotype; D012307:Risk Factors; D012907:Smoking; D011795:Surveys and Questionnaires
chemical_list: D003902:Detergents; D004202:Disinfectants; D007073:Immunoglobulin E