title: Lewy pathology and neurodegeneration in premotor Parkinson's disease.
abstract: The foremost motor manifestations of Parkinson's disease are resting tremor, cogwheel rigidity, hypokinesia/bradykinesia, and postural instability. Epidemiological and clinical data reveal that a wide variety of additional complaints (nonmotor symptoms), also considerably impar patients' quality of life parallel to the chronic-progressive neurodegenerative disorder. This article reviews the neuropathology and anatomy of Lewy pathology-related neurodegeneration in relation to selected nonmotro and prodromal dysfunctions.
authors.affiliation: Clinical Neuroanatomy Section, Department of Neurology, Center for Biomedical Research, University of Ulm, Ulm, Germany. kelly.del-tredici@uni-ulm.de
authors.forename: Kelly
authors.initials: K
authors.lastname: Del Tredici
authors.forename: Heiko
authors.initials: H
authors.lastname: Braak
mesh_terms: D006801:Humans; D016631:Lewy Bodies / Q000473:pathology*; D020961:Lewy Body Disease / Q000145:classification / Q000378:metabolism / Q000473:pathology*; D009046:Motor Neurons / Q000473:pathology*; D019636:Neurodegenerative Diseases / Q000145:classification / Q000473:pathology; D010300:Parkinson Disease / Q000145:classification / Q000473:pathology* / Q000503:physiopathology