title: Diversity of presynaptic calcium channels displaying different synaptic properties.
abstract: Why mediate P-/Q-type and not N-type Ca2+ channels in cerebellar inhibitory interneurons? Neurotransmitter release relies most on P-/Q- and N-type Ca2+ channels in the vast majority of neurons, although all types of voltage-gated Ca2+ channels are competent in initiating exocytosis. Up to date, it remains unclear why a particular Ca2+ channel type mediates neurotransmission in certain axon terminals and another type of Ca2+ channel evokes neurotransmission in axon terminals of another region. Therefore, the present review analyzes the diversity of presynaptic Ca2+ channels displaying different synaptic properties and focuses on an analysis of distribution and function of presynaptic voltage-gated Ca2+ channels, as well as on developmental changes.
authors.affiliation: Department f Neurosurgery, University Hospital, Heinrich-Heine-University, Düsseldorf, MoorenstraBe 5, D-40225, Düsseldorf, Germany. marcelalexander.kamp@uni-duesseldorf.de
authors.forename: Marcel A
authors.initials: MA
authors.lastname: Kamp
authors.forename: Daniel
authors.initials: D
authors.lastname: Hänggi
authors.forename: Hans-Jakob
authors.initials: HJ
authors.lastname: Steiger
authors.forename: Toni
authors.initials: T
authors.lastname: Schneider
mesh_terms: D000818:Animals; D001492:Bass; D020865:Calcium Channels, P-Type / Q000378:metabolism*; D020907:Calcium Channels, Q-Type / Q000378:metabolism*; D002531:Cerebellum / Q000378:metabolism; D002645:Chickens; D005089:Exocytosis / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D006801:Humans; D007395:Interneurons / Q000378:metabolism*; D017774:Long-Term Potentiation / Q000502:physiology; D051379:Mice; D017729:Presynaptic Terminals / Q000378:metabolism / Q000502:physiology*; D051381:Rats; D009435:Synaptic Transmission / Q000502:physiology*
chemical_list: D020865:Calcium Channels, P-Type; D020907:Calcium Channels, Q-Type