title: [Analysis of the perinatal outcome of the early severe preeclampsia women treated with Compound Danshen Injection and low molecular weight heparin].
abstract: OBJECTIVE
  To study the effects of using Compound Danshen Injection (CDI) and low molecular weight heparin (LMWH) on early severe preeclampsia women.
  
  
  METHODS
  Retrospective analysis was carried out in 95 patients with early severe preeclampsia from October 2008 to January 2011. They were assigned to 3 groups based on anticoagulant drugs. The routine therapy of magnesium sulfate (MgSO4) was given to the MgSO4 group (40 cases); the MgSO4 + CDI was given to those in the CDI group (23 cases), the MgSO4 + LMWH group was given to those in the LMWH group (32 cases). The general data of all patients were collected to analyze their effects on labor, postpartum hemorrhage, reasons for terminating the pregnancy, and maternal complications.
  
  
  RESULTS
  (1) The average gestational week (weeks) of terminating the pregnancy was 31.7 +/- 1.9 in the MgSO4 group, 33.0 +/- 1.8 in the CDI group, and 32.8 +/- 1.7 in the LMWH group. The average weight of newborn babies (g) was 1 450.5 +/- 402.3 in the MgSO4 group, 1 582.2 +/- 332.5 in the CDI group, and 1 590.0 +/- 340.1 in the LMWH group. There was no obviously difference in the average gestational weeks or the average weight of newborn babies among the three groups. (2) The way of terminating the pregnancy was uterine-incision delivery. The main reasons for operation were sequenced as maternal complications, unsatisfied control of the blood pressure, and fetal distress. (3) The maternal complications in the three groups were sequenced as renal failure (12 cases), placental abruption (9 cases), hemolysis, increased liver enzymes and low platelet (HELLP) syndrome (8 cases). Sixteen (40.0%) had complications in the MgSO4 group, 12 (52.2%) in the CDI group, and 15 (46.9%) in the LMWH group. No statistic difference existed among the 3 groups.
  
  
  CONCLUSIONS
  LMWH and CDI were helpful to improving the therapeutic effects of severe preeclampsia patients. They did not increase adverse drug reactions. They seemingly had effects on prolonging the gestational week.
authors.affiliation: Department of Obstetrics, Qilu Hospital of Shandong University, Jinan. liufen@sdu.edu.cn
authors.forename: Fen
authors.initials: F
authors.lastname: Liu
authors.forename: Yu-Yan
authors.initials: YY
authors.lastname: Ma
authors.forename: Yu-Gui
authors.initials: YG
authors.lastname: Xing
mesh_terms: D000328:Adult; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use*; D006801:Humans; D008278:Magnesium Sulfate / Q000627:therapeutic use; D010618:Phenanthrolines / Q000627:therapeutic use*; D011225:Pre-Eclampsia / Q000188:drug therapy*; D011247:Pregnancy; D011256:Pregnancy Outcome; D012189:Retrospective Studies; D027561:Salvia miltiorrhiza
chemical_list: D004365:Drugs, Chinese Herbal; D006495:Heparin, Low-Molecular-Weight; D010618:Phenanthrolines; C028972:dan-shen root extract; D008278:Magnesium Sulfate