title: Relationship between pancreatic and/or extrapancreatic lesions and serum IgG and IgG4 levels in IgG4-related diseases.
abstract: OBJECTIVE
  We aimed to investigate the relationship between the number of involved organs or regions and serum immunoglobulin G (IgG) and immunoglobulin G4 (IgG4) levels.
  
  
  METHODS
  The number of pancreatic and/or extrapancreatic lesions and serum IgG and IgG4 levels were examined by groups in 46 patients with IgG4-related diseases at diagnosis prior to the initiation of steroid treatment: group A (one region involved, n=7), group B (two regions involved, n=11), group C (three regions involved, n=12), group D (four regions involved, n=9) and group E (five to seven regions involved, n=7).
  
  
  RESULTS
  Both serum IgG and IgG4 levels increased with the number of inflamed regions. Mean serum IgG levels were 15.11, 18.65, 20.92, 23.29 and 30.98 g/L while the mean IgG4 levels were 3.99, 4.70, 4.70, 9.86 and 16.49 g/L in group A, B, C, D and E, respectively. Regression analysis also suggested that IgG4 was positively correlated with the number of regions involved. Additionally, serum IgG4 was higher in patients with multiple lesions when accompanied by sclerosing sialadenitis.
  
  
  CONCLUSIONS
  Patients having IgG4-related disease with high serum IgG and IgG4 levels should be systematically examined for involved lesions.
authors.affiliation: Department of Medicine and Bioregulatory Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. igaras@med.kyushu-u.ac.jp
authors.forename: Hisato
authors.initials: H
authors.lastname: Igarashi
authors.forename: Tetsuhide
authors.initials: T
authors.lastname: Ito
authors.forename: Takamasa
authors.initials: T
authors.lastname: Oono
authors.forename: Taichi
authors.initials: T
authors.lastname: Nakamura
authors.forename: Nao
authors.initials: N
authors.lastname: Fujimori
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Niina
authors.forename: Masayuki
authors.initials: M
authors.lastname: Hijioka
authors.forename: Masahiko
authors.initials: M
authors.lastname: Uchida
authors.forename: Ringaku
authors.initials: R
authors.lastname: Lee
authors.forename: Risa
authors.initials: R
authors.lastname: Iwao
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Nakamura
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Kotoh
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Takayanagi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001327:Autoimmune Diseases / Q000097:blood* / Q000175:diagnosis; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000473:pathology*; D010195:Pancreatitis / Q000097:blood / Q000276:immunology* / Q000473:pathology; D012044:Regression Analysis; D012793:Sialadenitis / Q000276:immunology* / Q000473:pathology
chemical_list: D007074:Immunoglobulin G