title: Organic synthesis using (diacetoxyiodo)benzene (DIB): Unexpected and novel oxidation of 3-oxo-butanamides to 2,2-dihalo-N-phenylacetamides.
abstract: A novel and reliable method for the direct preparation of 2,2-dihalo-N-phenylacetamides is reported. The key transformation involves the cleavage of a carbon-carbon bond in the presence of DIB and a Lewis acid as the halogen source, and thus this method significantly expands the value of DIB as a unique and powerful tool in chemical synthesis. This protocol not only adds a new aspect to reactions that use other hypervalent iodine reagents but also provides a wide space for the synthesis of disubstituted acetamides.
authors.affiliation: School of Chemistry and Life Science, Guangdong University of Petrochemical Technology, Maoming 525000, China.
authors.forename: Wei-Bing
authors.initials: WB
authors.lastname: Liu
authors.forename: Cui
authors.initials: C
authors.lastname: Chen
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhang
authors.forename: Zhi-Bo
authors.initials: ZB
authors.lastname: Zhu