title: Effects of Cinnamomum zeylanicum (Ceylon cinnamon) on blood glucose and lipids in a diabetic and healthy rat model.
abstract: OBJECTIVE
  To evaluate short- and long-term effects of Cinnamomum zeylanicum on food consumption, body weight, glycemic control, and lipids in healthy and diabetes-induced rats.
  
  
  METHODS
  The study was conducted in two phases (Phase I and Phase II), using Sprague-Dawley rats in four groups. Phase I evaluated acute effects on fasting blood glucose (FBG) (Groups 1 and 2) and on post-oral glucose (Groups 3 and 4) blood glucose. Groups 1 and 3 received distilled-water and Groups 2 and 4 received cinnamon-extracts. Phase II evaluated effects on food consumption, body weight, blood glucose, and lipids over 1 month. Group A (n = 8, distilled-water) and Group B (n = 8, cinnamon-extracts) were healthy rats, while Group C (n = 5, distilled-water) and Group D (n = 5, cinnamon-extracts) were diabetes-induced rats. Serum lipid profile and HbA1c were measured on D-0 and D-30. FBG, 2-h post-prandial blood glucose, body weight, and food consumption were measured on every fifth day.
  
  
  RESULTS
  
  
  
  METHODS
  There was no significant difference in serial blood glucose values in cinnamon-treated group from time 0 (P > 0.05). Following oral glucose, the cinnamon group demonstrated a faster decline in blood glucose compared to controls (P < 0.05). Phase II: Between D0 and D30, the difference in food consumption was shown only in diabetes-induced rats (P < 0.001). Similarly, the significant difference following cinnamon-extracts in FBG and 2-h post-prandial blood glucose from D0 to D30 was shown only in diabetes-induced rats. In cinnamon-extracts administered groups, total and LDL cholesterol levels were lower on D30 in both healthy and diabetes-induced animals (P < 0.001).
  
  
  CONCLUSIONS
  C. zeylanicum lowered blood glucose, reduced food intake, and improved lipid parameters in diabetes-induced rats.
authors.affiliation: Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Sri Lanka.
authors.forename: Priyanga
authors.initials: P
authors.lastname: Ranasinghe
authors.forename: Sanja
authors.initials: S
authors.lastname: Perera
authors.forename: Mangala
authors.initials: M
authors.lastname: Gunatilake
authors.forename: Eranga
authors.initials: E
authors.lastname: Abeywardene
authors.forename: Nuwan
authors.initials: N
authors.lastname: Gunapala
authors.forename: Sirimal
authors.initials: S
authors.lastname: Premakumara
authors.forename: Kamal
authors.initials: K
authors.lastname: Perera
authors.forename: Dilani
authors.initials: D
authors.lastname: Lokuhetty
authors.forename: Prasad
authors.initials: P
authors.lastname: Katulanda