title: Nonlinear indices of circadian changes in individuals with dementia and aggression.
abstract: Nonlinear analyses of actigraphy data were utilized to investigate circadian rest-activity system motor control in nursing-home residents with dementia and with/without aggressive behavior (AB). Significant differences observed between groups in measures of approximate entropy (ApEn) and fractal dimension (FD). ApEn and FD are sensitive to detecting and characterizing discrete changes in central motoric control and temporality of behaviors in dementia. Findings may inform understanding of clinical heterogeneity and possible physiologic sub-classifications of Alzheimer's dementia.
authors.affiliation: Wayne State University College of Nursing, 5557 Cass Avenue, Cohn Building Rm. 362, Detroit, MI 48202, USA. aq6671@wayne.edu
authors.forename: LuAnn
authors.initials: L
authors.lastname: Etcher
authors.forename: Ann
authors.initials: A
authors.lastname: Whall
authors.forename: Rahul
authors.initials: R
authors.lastname: Kumar
authors.forename: Davangere
authors.initials: D
authors.lastname: Devanand
authors.forename: Vikram
authors.initials: V
authors.lastname: Yeragani
mesh_terms: D056044:Actigraphy / Q000379:methods / Q000523:psychology; D000204:Activity Cycles / Q000502:physiology*; D000369:Aged, 80 and over; D000374:Aggression / Q000502:physiology*; D003704:Dementia / Q000150:complications / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D017711:Nonlinear Dynamics; D009735:Nursing Homes