title: New methodology for the synthesis of thiobarbiturates mediated by manganese(III) acetate.
abstract: A three step synthesis of various thiobarbiturate derivatives 17-24 was established. The first step is mediated by Mn(OAc)₃, in order to generate a carbon-carbon bond between a terminal alkene and malonate. Derivatives 1-8 were obtained in moderate to good yields under mild conditions. This key step allows synthesis of a wide variety of lipophilic thiobarbiturates, which could be tested for their anticonvulsive or anesthesic potential.
authors.affiliation: Laboratoire de Pharmaco-Chimie Radicalaire, Faculté de Pharmacie, Institut de Chimie Radicalaire ICR, UMR 7273, Aix-Marseille Univ, CNRS, 27 Bd Jean Moulin, CS 30064, 13385 Marseille Cedex 05, France.
authors.forename: Ahlem
authors.initials: A
authors.lastname: Bouhlel
authors.forename: Christophe
authors.initials: C
authors.lastname: Curti
authors.forename: Patrice
authors.initials: P
authors.lastname: Vanelle
mesh_terms: D000085:Acetates / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D009942:Organometallic Compounds / Q000737:chemistry*; D013858:Thiobarbiturates / Q000138:chemical synthesis*
chemical_list: D000085:Acetates; D009942:Organometallic Compounds; D013858:Thiobarbiturates; C521134:manganese(III) acetate dihydrate