title: Theory, fabrication and applications of microfluidic and nanofluidic biosensors.
abstract: Biosensors are a broad array of devices that detect the type and amount of a biological species or biomolecule. Several different types of biosensors have been developed that rely on changes to mechanical, chemical or electrical properties of the transduction or sensing element to induce a measurable signal. Often, a biosensor will integrate several functions or unit operations such as sample extraction, manipulation and detection on a single platform. This review begins with an overview of the current state-of-the-art biosensor field. Next, the review delves into a special class of biosensors that rely on microfluidics and nanofluidics by presenting the underlying theory, fabrication and several examples and applications of microfluidic and nanofluidic sensors.
authors.affiliation: Department of Mechanical and Aerospace Engineering, The Ohio State University, Columbus, 43210, USA. prakash.31@osu.edu
authors.forename: Shaurya
authors.initials: S
authors.lastname: Prakash
authors.forename: Marie
authors.initials: M
authors.lastname: Pinti
authors.forename: Bharat
authors.initials: B
authors.lastname: Bhushan
mesh_terms: D015374:Biosensing Techniques; D006801:Humans; D044085:Microfluidics; D008962:Models, Theoretical; D020349:Surface Plasmon Resonance