title: Use of thiazolidinedione and cancer risk in Type 2 diabetes: the Hong Kong diabetes registry.
abstract: We examined possible anticancer effects of thiazolidinediones (TZDs) in 6074 Chinese with Type 2 diabetes free of cancer at enrolment. During a median follow-up of 4.93 years, 270 patients developed cancer. Use of TZDs was associated with reduced risk of cancer in a dose-response manner in multivariable analysis.
authors.affiliation: Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, China. yangxilin@tijmu.edu.cn
authors.forename: Xilin
authors.initials: X
authors.lastname: Yang
authors.forename: Wing-Yee
authors.initials: WY
authors.lastname: So
authors.forename: Ronald C W
authors.initials: RC
authors.lastname: Ma
authors.forename: Linda W L
authors.initials: LW
authors.lastname: Yu
authors.forename: Alice P S
authors.initials: AP
authors.lastname: Kong
authors.forename: Heung Man
authors.initials: HM
authors.lastname: Lee
authors.forename: Gang
authors.initials: G
authors.lastname: Xu
authors.forename: Risa
authors.initials: R
authors.lastname: Ozaki
authors.forename: Gary T C
authors.initials: GT
authors.lastname: Ko
authors.forename: Juliana C N
authors.initials: JC
authors.lastname: Chan
mesh_terms: D000368:Aged; D044466:Asian People; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000453:epidemiology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D006723:Hong Kong / Q000453:epidemiology; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D008687:Metformin / Q000008:administration & dosage* / Q000009:adverse effects; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology* / Q000517:prevention & control*; D011237:Predictive Value of Tests; D012042:Registries; D045162:Thiazolidinediones / Q000008:administration & dosage* / Q000494:pharmacology
chemical_list: D007004:Hypoglycemic Agents; D045162:Thiazolidinediones; D008687:Metformin