title: Evaluation of possible subclinical atherosclerosis in adolescents with a family history of premature atherosclerosis.
abstract: OBJECTIVE
  To evaluate possible subclinical atherosclerosis using biomarkers and ultrasound-guided methods in a group of adolescents having fathers with premature atherosclerosis.
  
  
  METHODS
  Thirty-three subjects whose fathers had a history of premature coronary artery disease and 30 counterparts whose fathers had no history of coronary artery disease were included in the study.
  
  
  RESULTS
  The homocysteine levels, high-sensitivity C-reactive protein levels, and cardiac chamber sizes and functions did not differ between the two groups. The carotid stiffness index β (CSI), the intima-media thickness (CIMT) and aortic pulse wave velocity (PWV) values were higher in the group with a family history of coronary artery disease, but only the difference in the CSI was statistically significant (CSI 3.07±1.33 vs 3.88±1.25, P=0.015; CIMT 0.53±0.09 mm vs 0.57±0.08 mm, P=0.068; PWV 3.49±0.53 m/s vs 3.78±0.63 m/s, P=0.053).
  
  
  CONCLUSIONS
  Among several markers of subclinical atherosclerosis, the CSI was significantly higher in adolescents who had a family history of premature atherosclerosis. The small sample size, the multifactorial nature of atherosclerosis or the insufficient power of these methods may explain these results.
authors.affiliation: Gaziosmanpasa University, Faculty of Medicine, Department of Cardiology, Tokat, Turkey. dretaci@yahoo.com
authors.forename: Atac
authors.initials: A
authors.lastname: Celik
authors.forename: Mustafa
authors.initials: M
authors.lastname: Ozcetin
authors.forename: Zekiye Ruken Yuksekkaya
authors.initials: ZR
authors.lastname: Celikyay
authors.forename: Erkan
authors.initials: E
authors.lastname: Sogut
authors.forename: Yasemin
authors.initials: Y
authors.lastname: Yerli
authors.forename: Hasan
authors.initials: H
authors.lastname: Kadi
authors.forename: Fatih
authors.initials: F
authors.lastname: Koc
authors.forename: Ibrahim Halil
authors.initials: IH
authors.lastname: Damar
authors.forename: Koksal
authors.initials: K
authors.lastname: Ceyhan
authors.forename: Unal
authors.initials: U
authors.lastname: Erkorkmaz
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D001011:Aorta / Q000000981:diagnostic imaging / Q000503:physiopathology; D058070:Asymptomatic Diseases; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000503:physiopathology; D059168:Carotid Intima-Media Thickness; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000235:genetics / Q000503:physiopathology; D018619:Echocardiography, Doppler, Pulsed; D004548:Elasticity; D005220:Fathers; D005260:Female; D020022:Genetic Predisposition to Disease; D040941:Heredity; D006710:Homocysteine / Q000097:blood; D006801:Humans; D008297:Male; D010375:Pedigree; D010641:Phenotype; D011673:Pulsatile Flow; D018570:Risk Assessment; D012307:Risk Factors; D014421:Turkey / Q000453:epidemiology
chemical_list: D015415:Biomarkers; D006710:Homocysteine; D002097:C-Reactive Protein