title: From genes to environment: using integrative genomics to build a "systems-level" understanding of autism spectrum disorders.
abstract: Autism spectrum disorders (ASD) are pervasive neurodevelopmental disorders that affect an estimated 1 in 110 individuals. Although there is a strong genetic component associated with these disorders, this review focuses on the multifactorial nature of ASD and how different genome-wide (genomic) approaches contribute to our understanding of autism. Emphasis is placed on the need to study defined ASD phenotypes as well as to integrate large-scale "omics" data in order to develop a "systems-level" perspective of ASD, which in turn is necessary to allow predictions regarding responses to specific perturbations and interventions.
authors.affiliation: The George Washington University, School of Medicine and Health Sciences. valhu@gwu.edu
authors.forename: Valerie W
authors.initials: VW
authors.lastname: Hu
mesh_terms: D002648:Child; D002659:Child Development Disorders, Pervasive / Q000235:genetics*; D019175:DNA Methylation / Q000235:genetics; D004777:Environment; D020869:Gene Expression Profiling; D020022:Genetic Predisposition to Disease / Q000235:genetics; D055106:Genome-Wide Association Study; D023281:Genomics; D012739:Gonadal Steroid Hormones / Q000502:physiology; D006801:Humans; D035683:MicroRNAs / Q000235:genetics; D009434:Neural Pathways / Q000502:physiology; D057094:Nuclear Receptor Subfamily 1, Group F, Member 1 / Q000235:genetics; D010641:Phenotype; D059467:Transcriptome / Q000235:genetics
chemical_list: D012739:Gonadal Steroid Hormones; D035683:MicroRNAs; D057094:Nuclear Receptor Subfamily 1, Group F, Member 1; C539738:RORA protein, human