title: Nanomaterial-based treatments for medical device-associated infections.
abstract: Bacterial infections remain one of the biggest concerns to our society. Conventional antibiotic treatments showed little effect on the increasing number of antibiotic-resistant bacteria. Advances in synthetic chemistry and nanotechnology have resulted in a new class of nanometer-scale materials with distinguished properties and great potential to be an alternative for antibiotics. In this Minireview, we address the current situation of medical-device-associated infections and the emerging opportunities for antibacterial nanomaterials in preventing these complications. Several important antimicrobial nanomaterials emergent from advances in synthesis chemistry are introduced and their bactericidal mechanisms are analyzed. In addition, concerns regarding the biocompatibility of such materials are also addressed.
authors.affiliation: Department of Orthopaedics, Rhode Island Hospital and Alpert Medical School, Brown University, Providence, RI 02903, USA. nhiem_tran@brown.edu
authors.forename: Nhiem
authors.initials: N
authors.lastname: Tran
authors.forename: Phong A
authors.initials: PA
authors.lastname: Tran
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D023181:Antimicrobial Cationic Peptides / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects / Q000254:growth & development; D001424:Bacterial Infections / Q000188:drug therapy / Q000382:microbiology / Q000517:prevention & control*; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D018441:Biofilms / Q000187:drug effects* / Q000254:growth & development; D040761:Biomimetic Materials / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D055499:Catheter-Related Infections / Q000188:drug therapy / Q000382:microbiology / Q000517:prevention & control; D004864:Equipment and Supplies / Q000382:microbiology*; D006801:Humans; D053768:Metal Nanoparticles / Q000737:chemistry; D049329:Nanostructures / Q000737:chemistry*; D037742:Nanotubes, Carbon / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D001672:Biocompatible Materials; D037742:Nanotubes, Carbon