title: Monocyte chemoattractant protein 1 is correlated with glycemic control and peripheral arterial disease in type 2 diabetic patients with metabolic syndrome.
abstract: We evaluated the serum levels of monocyte chemoattractant protein 1 (MCP-1) and their association with peripheral arterial disease (PAD) in 199 patients with type 2 diabetes mellitus (T2DM) and metabolic syndrome ([MetS], group A) in comparison with 109 healthy controls (group B). In group A, MCP-1 levels were significantly (P < .001) higher than group B and exhibited a positive correlation with HbA1c (P < .001) and a negative correlation with ankle-brachial index (P < .001). In the same group, patients with PAD had significantly higher MCP-1 levels compared with those without PAD (P < .001). In conclusion, T2DM patients with MetS exhibit higher serum MCP-1 levels. The latter is associated with worse glycemic control and PAD. These results suggest a potential contributory role for MCP-1 in the pathogenesis of PAD in the presence of hyperglycemia and MetS in T2DM.
authors.affiliation: Second Department of Internal Medicine, Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis Greece. kpapatheo@yahoo.gr
authors.forename: K
authors.initials: K
authors.lastname: Papatheodorou
authors.forename: N
authors.initials: N
authors.lastname: Papanas
authors.forename: D
authors.initials: D
authors.lastname: Papazoglou
authors.forename: T
authors.initials: T
authors.lastname: Gioka
authors.forename: C
authors.initials: C
authors.lastname: Antonoglou
authors.forename: D
authors.initials: D
authors.lastname: Glaros
authors.forename: E
authors.initials: E
authors.lastname: Maltezos
mesh_terms: D000368:Aged; D055109:Ankle Brachial Index; D001786:Blood Glucose / Q000032:analysis*; D018932:Chemokine CCL2 / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000453:epidemiology; D005260:Female; D006442:Glycated Hemoglobin; D006801:Humans; D006943:Hyperglycemia / Q000453:epidemiology; D008297:Male; D024821:Metabolic Syndrome / Q000097:blood* / Q000453:epidemiology; D008875:Middle Aged; D058729:Peripheral Arterial Disease / Q000097:blood*; D012307:Risk Factors
chemical_list: D001786:Blood Glucose; D018932:Chemokine CCL2; D006442:Glycated Hemoglobin