title: Absence of an independent association between serum uric acid and left ventricular mass in Caucasian hypertensive women and men.
abstract: OBJECTIVE
  Experimentally uric acid may induce cardiomyocyte growth and interstitial fibrosis of the heart. However, clinical studies exploring the relationship between serum uric acid (SUA) and left ventricular (LV) mass yielded conflicting results. The aim of our study was to evaluate the relationships between SUA and LV mass in a large group of Caucasian essential hypertensive subjects.
  
  
  RESULTS
  We enrolled 534 hypertensive patients free of cardiovascular complications and without severe renal insufficiency. In all subjects routine blood chemistry, including SUA determination, echocardiographic examination and 24 h ambulatory blood pressure (BP) monitoring were obtained. In the overall population we observed no significant correlation of SUA with LV mass indexed for height(2.7) (LVMH(2.7)) (r = 0.074). When the same relationship was analysed separately in men and women, we found a statistically significant correlation in female gender (r = 0.27; p < 0.001), but not in males (r = -0.042; p = NS). When we grouped the study population in sex-specific tertiles of SUA, an increase in LVMH(2.7) was observed in the highest tertiles in women (44.5 ± 15.6 vs 47.5 ± 16 vs 55.9 ± 22.2 g/m(2.7); p < 0.001), but not in men. The association between SUA and LVMH(2.7) in women lost statistical significance in multiple regression analyses, after adjustment for age, 24 h systolic BP, body mass index, serum creatinine and other potential confounders.
  
  
  CONCLUSIONS
  Our findings do not support an independent association between SUA and LV mass in Caucasian men and women with arterial hypertension.
authors.affiliation: Dipartimento di Medicina Interna e Specialistica, Cattedra di Medicina Interna e Cattedra di Nefrologia, European Society of Hypertension Excellence Centre, Università di Palermo, Via del Vespro 129, 90127 Palermo, Italy. giuseppe.mule@unipa.it
authors.forename: G
authors.initials: G
authors.lastname: Mulè
authors.forename: E
authors.initials: E
authors.lastname: Nardi
authors.forename: M
authors.initials: M
authors.lastname: Costanzo
authors.forename: M
authors.initials: M
authors.lastname: Mogavero
authors.forename: L
authors.initials: L
authors.lastname: Guarino
authors.forename: T
authors.initials: T
authors.lastname: Viola
authors.forename: M G
authors.initials: MG
authors.lastname: Vario
authors.forename: V
authors.initials: V
authors.lastname: Cacciatore
authors.forename: G
authors.initials: G
authors.lastname: Andronico
authors.forename: G
authors.initials: G
authors.lastname: Cerasola
authors.forename: S
authors.initials: S
authors.lastname: Cottone
mesh_terms: D000328:Adult; D001794:Blood Pressure; D018660:Blood Pressure Monitoring, Ambulatory; D015992:Body Mass Index; D003404:Creatinine / Q000097:blood; D003430:Cross-Sectional Studies; D004452:Echocardiography; D005260:Female; D006352:Heart Ventricles / Q000503:physiopathology*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D014527:Uric Acid / Q000097:blood*; D044465:White People
chemical_list: D014527:Uric Acid; D003404:Creatinine