title: iPSCs from cancer cells: challenges and opportunities.
abstract: Reprogramming and oncogenic transformation are stepwise processes that share many similarities, and induced pluripotent stem cells (iPSCs) generated from cancer cells could illuminate molecular mechanisms underlying the pathogenesis of human cancer. Deciphering the barriers underlying the reprogramming process of primary cancer cells could reveal information on the links between pluripotency and oncogenic transformation that would be instrumental for therapy development.
authors.affiliation: Pfizer-University of Granada-Andalusian Government Centre for Genomics and Oncological Research (GENyO), Avda de la Ilustración 114, 18007, Granada, Spain.
authors.forename: Verónica
authors.initials: V
authors.lastname: Ramos-Mejia
authors.forename: Mario F
authors.initials: MF
authors.lastname: Fraga
authors.forename: Pablo
authors.initials: P
authors.lastname: Menendez
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D065150:Cellular Reprogramming; D006801:Humans; D057026:Induced Pluripotent Stem Cells / Q000166:cytology* / Q000378:metabolism; D009369:Neoplasms / Q000235:genetics / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism
chemical_list: D014157:Transcription Factors