title: Autocrine PDGF stimulation in malignancies.
abstract: Platelet-derived growth factor (PDGF) isoforms are important mitogens for different types of mesenchymal cells, which have important functions during the embryonal development and in the adult during wound healing and tissue homeostasis. In tumors, PDGF isoforms are often over-expressed and contribute to the growth of both normal and malignant cells. This review focuses on tumors expressing PDGF isoforms together with their tyrosine kinase receptors, thus resulting in autocrine stimulation of growth and survival. Patients with such tumors could benefit from treatment with inhibitors of either PDGF or PDGF receptors.
authors.affiliation: Ludwig Institute for Cancer Research, Uppsala University, Uppsala, Sweden.
authors.forename: Carl-Henrik
authors.initials: CH
authors.lastname: Heldin
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D009154:Mutation; D009369:Neoplasms / Q000188:drug therapy / Q000503:physiopathology*; D020575:Oncogene Proteins v-sis / Q000737:chemistry; D010982:Platelet-Derived Growth Factor / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000502:physiology*; D020033:Protein Isoforms / Q000502:physiology*; D017479:Receptors, Platelet-Derived Growth Factor / Q000235:genetics
chemical_list: D000970:Antineoplastic Agents; D020575:Oncogene Proteins v-sis; D010982:Platelet-Derived Growth Factor; D020033:Protein Isoforms; D017479:Receptors, Platelet-Derived Growth Factor