title: CK20 expression enhances the invasiveness of tamoxifen-resistant MCF-7 cells.
abstract: Cytokeratin 20 (CK20) is an intermediate filament that is known to be a prognostic marker in several types of cancer. However, little is known about CK20 expression and tumor metastasis in tamoxifen-resistant MCF-7 (TRM-7) breast cancer cells. TRM-7 cells overexpress CK20, resulting in enhanced invasiveness in vitro. CK20 silencing reduced the invasiveness of TRM-7 cells. Moreover, CK20 expression in MCF-7 cells was regulated by peroxisome proliferator-activated receptor γ (PPARγ). Our findings suggest that PPARγ-dependent CK20 expression enhances the metastatic potential of MCF-7 breast cancer cells and may be a potential therapeutic target in tamoxifen-resistant breast cancer.
authors.affiliation: Department of Pharmacology, Seoul National University College of Medicine, Seoul, Republic of Korea.
authors.forename: Yun Sook
authors.initials: YS
authors.lastname: Min
authors.forename: Eun Hee
authors.initials: EH
authors.lastname: Yi
authors.forename: Jin Koo
authors.initials: JK
authors.lastname: Lee
authors.forename: Ji Won
authors.initials: JW
authors.lastname: Choi
authors.forename: Ji Hyun
authors.initials: JH
authors.lastname: Sim
authors.forename: Jae-Seung
authors.initials: JS
authors.lastname: Kang
authors.forename: Yong-Nyun
authors.initials: YN
authors.lastname: Kim
authors.forename: Yong-Sung
authors.initials: YS
authors.lastname: Juhnn
authors.forename: Hang-Rae
authors.initials: HR
authors.lastname: Kim
authors.forename: Sang-Kyu
authors.initials: SK
authors.lastname: Ye
mesh_terms: D018931:Antineoplastic Agents, Hormonal / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology; D045744:Cell Line, Tumor; D019008:Drug Resistance, Neoplasm; D006801:Humans; D053554:Keratin-20 / Q000235:genetics / Q000378:metabolism*; D009361:Neoplasm Invasiveness; D047495:PPAR gamma / Q000235:genetics / Q000378:metabolism; D013629:Tamoxifen / Q000494:pharmacology*
chemical_list: D018931:Antineoplastic Agents, Hormonal; D053554:Keratin-20; D047495:PPAR gamma; D013629:Tamoxifen