title: Matrix metallopropteinases in heart failure.
abstract: Heart failure (HF) represents a complex multifactorial syndrome, characterized by crucial structural and functional abnormalities of the myocardium. Matrix metalloproteinases are associated with left ventricular dysfunction, adverse left ventricular remodelling and prognosis after acute myocardial infarction. There is a strong association between oxidative stress and MMPs in the pathophysiology of HF. As MMPs are strongly associated to the pathogenesis and pathophysiology of HF, several agents have been proposed as potential modulators of these molecules. Classical agents such as statins, angiotensin converting enzyme inhibitors (ACEIS) and beta-blockers and a variety of novel agents have been implicated in the pathogenesis and progression of heart failure via the matrix metalloproteinases pathway and consist of possible future therapeutic targets.
authors.affiliation: 1st Cardiology Unit, Hippokration Hospital, Athens University Medical School, Athens, Greece. drtousoulis@hotmail.com
authors.forename: Dimitris
authors.initials: D
authors.lastname: Tousoulis
authors.forename: Anna-Maria
authors.initials: AM
authors.lastname: Kampoli
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Papageorgiou
authors.forename: Charalambos
authors.initials: C
authors.lastname: Antoniades
authors.forename: Gerasimos
authors.initials: G
authors.lastname: Siasos
authors.forename: George
authors.initials: G
authors.lastname: Latsios
authors.forename: Eleftherios
authors.initials: E
authors.lastname: Tsiamis
authors.forename: Christodoulos
authors.initials: C
authors.lastname: Stefanadis
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000818:Animals; D006333:Heart Failure / Q000201:enzymology* / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D020782:Matrix Metalloproteinases / Q000378:metabolism*; D009203:Myocardial Infarction / Q000503:physiopathology; D018487:Ventricular Dysfunction, Left / Q000378:metabolism; D020257:Ventricular Remodeling / Q000502:physiology*
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D020782:Matrix Metalloproteinases