title: Motor unit number estimation and motor unit action potential analysis in carpal tunnel syndrome.
abstract: OBJECTIVE
  To evaluate the clinical significance of motor unit number estimation (MUNE) and quantitative analysis of motor unit action potential (MUAP) in carpal tunnel syndrome (CTS) according to electrophysiologic severity, ultrasonographic measurement and clinical symptoms.
  
  
  METHODS
  We evaluated 78 wrists of 45 patients, who had been diagnosed with CTS and 42 wrists of 21 healthy controls. Median nerve conduction studies, amplitude and duration of MUAP, and the MUNE of the abductor pollicis brevis were measured. The cross sectional area (CSA) of the median nerve at the pisiform and distal radioulnar joint level was determined by high resolution ultrasonography. Clinical symptom of CTS was assessed using the Boston Carpal Tunnel Questionnaire (BCTQ).
  
  
  RESULTS
  The MUNE, the amplitude and the duration of MUAP of the CTS group were significantly different from those found in the control group. The area under the ROC curve was 0.944 for MUNE, 0.923 for MUAP amplitude and 0.953 for MUAP duration. MUNE had a negative correlation with electrophysiologic stage of CTS, amplitude and duration of MUAP, CSA at pisiform level, and the score of BCTQ. The amplitude and duration of MUAP had a positive correlation with the score of BCTQ. The electrophysiologic stage was correlated with amplitude but not with the duration of MUAP.
  
  
  CONCLUSIONS
  MUNE, amplitude and duration of MUAP are useful tests for diagnosis of CTS. In addition, the MUNE serves as a good indicator of CTS severity.
authors.affiliation: Department of Rehabilitation Medicine, School of Medicine, Chungnam National University, Daejeon 301-172, Korea.
authors.forename: Min Kyun
authors.initials: MK
authors.lastname: Sohn
authors.forename: Sung Ju
authors.initials: SJ
authors.lastname: Jee
authors.forename: Seon Lyul
authors.initials: SL
authors.lastname: Hwang
authors.forename: Young-Jae
authors.initials: YJ
authors.lastname: Kim
authors.forename: Hyun-Dae
authors.initials: HD
authors.lastname: Shin