title: Molecular and spatial constraints on NB-LRR receptor signaling.
abstract: In plants, a large polymorphic family of intracellular NB-LRR receptors lies at the heart of robust resistance to diverse pathogens and mechanisms by which these versatile molecular switches operate in effector-triggered immunity are beginning to emerge. We outline recent advances in our understanding of NB-LRR receptor signaling leading to disease resistance. Themes covered are (i) NB-LRR molecular constraining forces and their intimate relationship with receptor activation in different parts of the cell, (ii) cooperativity between NB-LRR proteins and the formation of higher order NB-LRR signaling complexes, and (iii) the spatial separation of different resistance branches within cells. Finally, we examine evidence for dynamic signaling across cell compartments in coordinating diverse immune outputs.
authors.affiliation: Department of Plant-Microbe Interactions, Max Planck Institute for Plant Breeding Research, Carl-von-Linne Weg 10, 50829 Cologne, Germany.
authors.forename: Katharina
authors.initials: K
authors.lastname: Heidrich
authors.forename: Servane
authors.initials: S
authors.lastname: Blanvillain-Baufumé
authors.forename: Jane E
authors.initials: JE
authors.lastname: Parker
mesh_terms: D060467:Disease Resistance / Q000276:immunology*; D054884:Host-Pathogen Interactions / Q000276:immunology*; D051756:Leucine-Responsive Regulatory Protein / Q000737:chemistry* / Q000378:metabolism*; D057865:Plant Immunity / Q000502:physiology; D010944:Plants / Q000276:immunology* / Q000382:microbiology*; D011487:Protein Conformation; D015398:Signal Transduction / Q000276:immunology*
chemical_list: D051756:Leucine-Responsive Regulatory Protein