title: Triterpenes from Callicarpa integerrima Champ.
abstract: A new triterpenoid saponin and fourteen known triterpenoids were isolated from the methanol extract of the stems and leaves of Callicarpa integerrima Champ, which is used in Chinese folk medicine for stopping bleeding, expelling the wind, dissipating stagnation, and treating scrofula, by using various chromatographies, such as silica gel, Sephadex LH-20 and RP-C18 column chromatography. Their structures were identified as a new compound 2alpha, 3beta, 19alpha, 23-tetrahydroxy-olean-12-en-28-oic acid-28-O-beta-D-glucopyranosyl-(1 --> 4)-beta-D-glucopyranoside (1), together with fourteen known compounds: oleanolic acid (2), 3-acetyl oleanolic acid (3), 3beta-O-acetyl ursolic acid (4), 2alpha-hydroxy-ursolic acid (5), 2alpha, 3beta, 19alpha, 23-tetrahydroxy-urs-12-en-28-oic acid (6), alpha-amyrin-3-O-beta-D-glucopyranoside (7), pomolic acid (8), betulinic acid (9), ursolic acid (10), 2alpha, 3beta, 19alpha, 23-tetrahydroxy-olean-12-en-28-oic acid (arjungenin) (11), 2alpha-hydroxy-oleanolic acid (12), hederagenin (13), 2alpha, 19alpha-dihydroxy-ursolic acid (14) and pruvuloside A (15), by the spectroscopic techniques of NMR, HMBC, IR and MS, separately. All these compounds were obtained from this plant for the first time, and compounds 3, 4 and 15 were isolated from genus Callicarpa L. for the first time.
authors.affiliation: School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
authors.forename: Chen-Chen
authors.initials: CC
authors.lastname: Zhu
authors.forename: Li
authors.initials: L
authors.lastname: Gao
authors.forename: Zhong-Xiang
authors.initials: ZX
authors.lastname: Zhao
authors.forename: Chao-Zhan
authors.initials: CZ
authors.lastname: Lin
mesh_terms: D032408:Callicarpa / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D053978:Pentacyclic Triterpenes; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification*; D000094062:Betulinic Acid; D000097245:Ursolic Acid
chemical_list: D009828:Oleanolic Acid; D053978:Pentacyclic Triterpenes; D012503:Saponins; D014315:Triterpenes; D000094062:Betulinic Acid; D000097245:Ursolic Acid; C412810:2-hydroxyursolic acid; C582233:2alpha,3beta,19alpha,23-tetrahydroxy-olean-12-en-28-oic acid-28-O-beta-D-glucopyranosyl-(1-4)-beta-D-glucopyranoside; C052658:oleanolic acid 3-acetate; C115535:pomolic acid; C025763:hederagenin