title: CD105 and placental growth factor--potent prognostic factors in childhood acute lymphoblastic leukaemia.
abstract: The studies aimed at identifying a prognostic significance of angiogenesis-related factors: CD105 and placental growth factor (PlGF) in a course of acute lymphoblastic leukaemia (ALL). Research protocol was based on detection of RNA and protein expressions in bone marrow blasts using quantitative PCR and immunocytochemical assays respectively. Kaplan-Meier statistics revealed CD105 and PlGF expression as managed separately do not correlate with relapse-free time in ALL patients. On the other hand, an associated analysis of CD105 and PlGF demonstrated a significantly shorter progression-free time in children who were CD105+ and PlGF+ or CD105- and PlGF+ at the moment of ALL diagnosis.
authors.affiliation: Department of Histology and Embryology, University of Medical Sciences, Poznan, Poland.
authors.forename: Patrycja
authors.initials: P
authors.lastname: Sujka-Kordowska
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Malinska
authors.forename: Danuta
authors.initials: D
authors.lastname: Ostalska-Nowicka
authors.forename: Maciej
authors.initials: M
authors.lastname: Zabel
authors.forename: Michal
authors.initials: M
authors.lastname: Nowicki
mesh_terms: D017668:Age of Onset; D015703:Antigens, CD / Q000032:analysis / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics / Q000378:metabolism; D016022:Case-Control Studies; D002648:Child; D000071063:Endoglin; D015973:Gene Expression Regulation, Leukemic; D006801:Humans; D007150:Immunohistochemistry; D008991:Monitoring, Physiologic / Q000379:methods; D000072483:Placenta Growth Factor; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics / Q000378:metabolism; D011257:Pregnancy Proteins / Q000032:analysis / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D011379:Prognosis; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000032:analysis / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D012307:Risk Factors; D016019:Survival Analysis; D013997:Time Factors
chemical_list: D015703:Antigens, CD; D014408:Biomarkers, Tumor; C064206:ENG protein, human; D000071063:Endoglin; C000608036:PGF protein, human; D011257:Pregnancy Proteins; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D000072483:Placenta Growth Factor