title: Does celiac disease occur in Afro-derived Brazilian populations?
abstract: BACKGROUND
  Celiac disease is an autoimmune disorder that occurs in genetically susceptible individuals in whom the ingestion of dietary gluten induces intestinal mucosa inflammation. Previous studies suggest that celiac disease may either be very rare or underdiagnosed in African and/or African-derived population.
  
  
  OBJECTIVE
  Determine the prevalence of celiac disease in Sub-Saharan African-derived Brazilian communities using serological screening.
  
  
  METHODS
  Inhabitants from 10 African-derived communities from Northeastern of Brazil were screened for celiac disease. All sera were tested for endomysial class IgA antibody using indirect immunofluorescence.
  
  
  RESULTS
  No positive test for IgA-endomysial was observed in the 860 individuals tested.
  
  
  CONCLUSIONS
  Our data suggests a low prevalence of celiac disease in African-derived Brazilian populations.
authors.affiliation: Faculdade de Medicina, Centro de Pesquisa em Doença Celíaca, Universidade de Brasília, Distrito Federal, Brazil.
authors.forename: Rodrigo C
authors.initials: RC
authors.lastname: Almeida
authors.forename: Lenora
authors.initials: L
authors.lastname: Gandolfi
authors.forename: Maria
authors.initials: M
authors.lastname: De Nazaré Klautau-Guimarães
authors.forename: Iris
authors.initials: I
authors.lastname: Ferrari
authors.forename: Sandra M B
authors.initials: SM
authors.lastname: Sousa
authors.forename: Kiyoko
authors.initials: K
authors.lastname: Abe-Sandes
authors.forename: Ana A L
authors.initials: AA
authors.lastname: Barbosa
authors.forename: Aguinaldo L
authors.initials: AL
authors.lastname: Simões
authors.forename: Riccardo
authors.initials: R
authors.lastname: Pratesi
authors.forename: Silviene F
authors.initials: SF
authors.lastname: Oliveira
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology; D001327:Autoimmune Diseases / Q000453:epidemiology / Q000276:immunology; D044383:Black People; D001938:Brazil / Q000453:epidemiology; D002446:Celiac Disease / Q000453:epidemiology* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood / Q000276:immunology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D055815:Young Adult
chemical_list: D001323:Autoantibodies; D007070:Immunoglobulin A