title: Influence of cosolvents, ionic strength and the method of sample preparation on the solubilization of curcumin by Pluronics and HP-gamma-cyclodextrin. Studies of curcumin and curcuminoids, XLIV.
abstract: Curcumin was solubilized by Pluronics and the concentration of dissolved curcumin seemed to be related to the number of propylene oxide units in the Pluronic polymer. All Pluronics showed a maximum solubilizing capacity at a certain curcumin: Pluronic molar ratio and exceeding this molar ratio resulted in precipitation of curcumin when following the samples for 356 hours. PEG 400 could to a certain extent stabilize the supersaturated samples, while ethanol physically destabilized the samples. Ionic strength did not influence the solubilization of curcumin by the Pluronics. Supersaturation and precipitation inhibition caused a higher concentration of curcumin in samples prepared by SEM compared to samples prepared by SFM (i.e. the thermodynamic solubility).
authors.affiliation: School of Pharmacy, Department of Pharmaceutics, University of Oslo, Blindern, Norway. ravindersingh@farmasi.uio.no
authors.forename: R
authors.initials: R
authors.lastname: Singh
authors.forename: S
authors.initials: S
authors.lastname: Kristensen
authors.forename: H H
authors.initials: HH
authors.lastname: Tønnesen
mesh_terms: D000327:Adsorption; D002138:Calibration; D002152:Calorimetry, Differential Scanning; D002851:Chromatography, High Pressure Liquid; D003474:Curcumin / Q000737:chemistry*; D008823:Micelles; D008855:Microscopy, Electron, Scanning; D008970:Molecular Weight; D009994:Osmolar Concentration; D020442:Poloxamer / Q000737:chemistry*; D012015:Reference Standards; D015203:Reproducibility of Results; D012995:Solubility; D012997:Solvents; D013048:Specimen Handling; D047408:gamma-Cyclodextrins / Q000737:chemistry*
chemical_list: D008823:Micelles; D012997:Solvents; D047408:gamma-Cyclodextrins; C479659:hydroxypropyl-gamma-cyclodextrin; D020442:Poloxamer; D003474:Curcumin