title: Palladium-catalyzed alkylation of 1,4-dienes by C-H activation.
abstract: Activated: the title reaction proceeds with a broad range of nucleophiles and variously substituted 1,4-dienes under mild conditions, and provides direct access to the corresponding 1,3-diene-containing products with high regio- and stereocontrol (see scheme; 2,6-DMBQ=2,6-dimethylbenzoquinone, EWG=electron-withdrawing group). This is the first catalytic allylic C-H alkylation that proceeds in the absence of sulfoxide ligands.
authors.affiliation: Department of Chemistry, Stanford University, CA 94305-5080, USA. bmtrost@stanford.edu.
authors.forename: Barry M
authors.initials: BM
authors.lastname: Trost
authors.forename: Max M
authors.initials: MM
authors.lastname: Hansmann
authors.forename: David A
authors.initials: DA
authors.lastname: Thaisrivongs