title: A review of genetic epidemiology of head and neck cancer related to polymorphisms in metabolic genes, cell cycle control and alcohol metabolism.
abstract: The purpose of this report is to review the relationship between genetic polymorphisms involved in carcinogen metabolism, alcohol metabolism and cell-cycle control with the risk of head and neck cancer. The review was performed on available studies on genetic polymorphisms and head and neck cancer (HNC) published in PubMed up to September 2011. 246 primary articles and 7 meta-analyses were published. Among these, a statistically significant association was reported for glutathione S-transferases (GSTM1), glutathione S-transferases (GSTT1) and human microsomal epoxide hydrolase (EPHX1) genes. An increased risk for HNC was also associated reported for P53 codon 72 Pro/Pro, ALDH2 and three variants of the ADH gene: ADH1B (rs1229984), ADH7 (rs1573496) and ADH1C (rs698).
authors.affiliation: Institute of Otorhinolaryngology, Università Cattolica del Sacro Cuore, Rome, Italy. gabriella.cadoni@rm.unicatt.it
authors.forename: G
authors.initials: G
authors.lastname: Cadoni
authors.forename: S
authors.initials: S
authors.lastname: Boccia
authors.forename: L
authors.initials: L
authors.lastname: Petrelli
authors.forename: P
authors.initials: P
authors.lastname: Di Giannantonio
authors.forename: D
authors.initials: D
authors.lastname: Arzani
authors.forename: A
authors.initials: A
authors.lastname: Giorgio
authors.forename: E
authors.initials: E
authors.lastname: De Feo
authors.forename: M
authors.initials: M
authors.lastname: Pandolfini
authors.forename: P
authors.initials: P
authors.lastname: Gallì
authors.forename: G
authors.initials: G
authors.lastname: Paludetti
authors.forename: G
authors.initials: G
authors.lastname: Ricciardi
mesh_terms: D059447:Cell Cycle Checkpoints / Q000235:genetics*; D000431:Ethanol / Q000378:metabolism*; D006258:Head and Neck Neoplasms / Q000453:epidemiology* / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D008660:Metabolism / Q000235:genetics; D017720:Molecular Epidemiology; D011110:Polymorphism, Genetic
chemical_list: D000431:Ethanol