title: Exploring the role of BCHE in the onset of Diabetes, Obesity and Neurological Disorders.
abstract: Diabetes, Obesity and Neurological disturbances, most often show co-occurrence. There has been an extensive research in this domain, but the exact mechanism underlying the co-occurrence of the three conditions is still an enigma. The current paper is an approach to establish the role of Butyryl cholinesterase (BCHE) in Diabetes, Obesity and Neurological disorders by performing a comparative analysis with Neuroligin (NLGN2) a protein belonging to the same family. BCHE has its role in glucose regulation, Lipid metabolism and nerve signaling. Emphasis is laid on BCHE's diverse functions whose impediment affects the above mentioned metabolic pathways. Insilco techniques were employed to analyze the sequence, structural and functional similarities of the two proteins. A point mutation is focused which is common to both BCHE and Neuroligin. The mutation occurs at the homologous position in both the proteins making them deficient. This affects the three metabolic pathways leading to the respective disorders. The work describes the pathway that describes the role of BCHE in the onset of obesity mediated diabetes. The pathway further explains the association between Diabetes, Obesity and neurological disturbances.
authors.forename: Allam Appa
authors.initials: AA
authors.lastname: Rao
authors.forename: Gundlapally
authors.initials: G
authors.lastname: Jyothsna
authors.forename: Pulipati
authors.initials: P
authors.lastname: Shalini
authors.forename: Amit
authors.initials: A
authors.lastname: Kumar
authors.forename: Anupam
authors.initials: A
authors.lastname: Bhattacharya
authors.forename: Amita
authors.initials: A
authors.lastname: Kashyap