title: Hydroxyapatite nanorods: soft-template synthesis, characterization and preliminary in vitro tests.
abstract: Synthetic hydroxyapatite nanorods are excellent candidates for bone tissue engineering applications. In this study, hydroxyapatite nanorods resembling bone minerals were produced by using soft-template method with cetyltrimethylammonium bromide. Composite hydroxyapatite/poly(D, L)lactic acid films were prepared to evaluate the prepared hydroxyapatite nanorods in terms of cell affinity. Preliminary in vitro experiments showed that aspect ratio and film surface roughness play a vital role in controlling adhesion and proliferation of human osteoblast cell line MG 63. The hydroxyapatite nanorods with aspect ratios in the range of 5.94-7 were found to possess distinctive properties, with the corresponding hydroxyapatite/poly(D, L)lactic acid films promoting cellular confluence and a fast formation of collagen fibers as early as after 7 days of culture.
authors.affiliation: Department of Materials Engineering and Industrial Technologies and BIOtech Research Center, University of Trento, Trento, Italy.
authors.forename: Nga Kim
authors.initials: NK
authors.lastname: Nguyen
authors.forename: Matteo
authors.initials: M
authors.lastname: Leoni
authors.forename: Devid
authors.initials: D
authors.lastname: Maniglio
authors.forename: Claudio
authors.initials: C
authors.lastname: Migliaresi
mesh_terms: D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry; D018786:Bone Substitutes / Q000138:chemical synthesis / Q000737:chemistry*; D002448:Cell Adhesion; D002460:Cell Line; D049109:Cell Proliferation; D003094:Collagen / Q000096:biosynthesis; D017886:Durapatite / Q000138:chemical synthesis / Q000737:chemistry*; D006801:Humans; D019344:Lactic Acid / Q000138:chemical synthesis / Q000737:chemistry; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D053761:Nanocomposites / Q000737:chemistry; D043942:Nanotubes / Q000737:chemistry* / Q000648:ultrastructure; D010006:Osteoblasts / Q000166:cytology / Q000378:metabolism; D011091:Polyesters; D011108:Polymers / Q000138:chemical synthesis / Q000737:chemistry; D023822:Tissue Engineering
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide); D003094:Collagen; D017886:Durapatite