title: Impaired mitochondrial function in psychiatric disorders.
abstract: Major psychiatric illnesses such as mood disorders and schizophrenia are chronic, recurrent mental illnesses that affect the lives of millions of individuals. Although these disorders have traditionally been viewed as 'neurochemical diseases', it is now clear that they are associated with impairments of synaptic plasticity and cellular resilience. Although most patients with these disorders do not have classic mitochondrial disorders, there is a growing body of evidence to suggest that impaired mitochondrial function may affect key cellular processes, thereby altering synaptic functioning and contributing to the atrophic changes that underlie the deteriorating long-term course of these illnesses. Enhancing mitochondrial function could represent an important avenue for the development of novel therapeutics and also presents an opportunity for a potentially more efficient drug-development process.
authors.affiliation: Janssen Research & Development, LLC, Raritan, New Jersey 08869, USA. hmanji@its.jnj.com
authors.forename: Husseini
authors.initials: H
authors.lastname: Manji
authors.forename: Tadafumi
authors.initials: T
authors.lastname: Kato
authors.forename: Nicholas A
authors.initials: NA
authors.lastname: Di Prospero
authors.forename: Seth
authors.initials: S
authors.lastname: Ness
authors.forename: M Flint
authors.initials: MF
authors.lastname: Beal
authors.forename: Michael
authors.initials: M
authors.lastname: Krams
authors.forename: Guang
authors.initials: G
authors.lastname: Chen
mesh_terms: D000818:Animals; D004734:Energy Metabolism / Q000502:physiology; D006801:Humans; D001523:Mental Disorders / Q000378:metabolism* / Q000473:pathology* / Q000628:therapy; D008928:Mitochondria / Q000378:metabolism* / Q000473:pathology*; D028361:Mitochondrial Diseases / Q000378:metabolism* / Q000473:pathology* / Q000628:therapy; D009474:Neurons / Q000378:metabolism / Q000473:pathology; D013569:Synapses / Q000378:metabolism / Q000473:pathology