title: [Analysis of the toll-like receptor 2 Arg753Gln gene polymorphisms of acne patients of Gan-depression induced qi stagnation syndrome and damp-heat in the interior syndrome].
abstract: OBJECTIVE
  To study the toll-like receptor 2 (TLR2) Arg753Gln gene polymorphisms of acne patients of Gan-depression induced qi stagnation syndrome and damp-heat in the interior syndrome, thus laying the foundation for genetics studies on its occurrence.
  
  
  METHODS
  The distribution and the frequency of allelic genes were studied in 75 acne patients of damp-heat in the interior syndrome, and 87 acne patients with Gan-depression induced qi stagnation syndrome, as well as 70 healthy subjects (as the normal control group) using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique.
  
  
  RESULTS
  There was significant difference in the frequency of the genotype Arg/Gln + Gln/Gln in the TLR2 Arg753Gln genetic polymorphisms [26. 44% (23/87) in Gan-depression induced qi stagnation syndrome, 41.33% (31/75) in damp-heat in the interior syndrome, and 12.86% (9/70) in the normal control group] (P < 0.05).
  
  
  CONCLUSIONS
  The existence of 753Gln allele in the Arg753Gln of TLR2 increased the onset risk of acne patients of Gan-depression induced qi stagnation syndrome and damp-heat in the interior syndrome.
authors.affiliation: Department of Dermatology, First Hospital Affiliated to Huazhong University of Science and Technology, Wuhan. jolly180@yahoo.cn
authors.forename: Li-Ming
authors.initials: LM
authors.lastname: Tian
authors.forename: Wei-Zhen
authors.initials: WZ
authors.lastname: Wang
authors.forename: Tin
authors.initials: T
authors.lastname: Yang
mesh_terms: D000152:Acne Vulgaris / Q000175:diagnosis / Q000208:ethnology / Q000235:genetics*; D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008516:Medicine, Chinese Traditional; D010641:Phenotype; D011110:Polymorphism, Genetic; D019413:Qi; D051195:Toll-Like Receptor 2 / Q000235:genetics*; D055815:Young Adult
chemical_list: C495342:TLR2 protein, human; D051195:Toll-Like Receptor 2