title: Cannabinoid receptor 1 inhibition causes seizures during anesthesia induction in experimental sepsis.
abstract: We report on seizures during anesthesia induction in animals treated with a cannabinoid receptor 1 (CB1R) antagonist for experimental sepsis. Animals received surgery for colon ascendens stent peritonitis-induced sepsis or sham surgery followed by treatment of CB1R antagonist, CB1R agonist, or placebo. Fourteen hours later, animals received pentobarbital or ketamine for anesthesia induction and animal behavior was observed. Tonic-clonic seizures were observed in 5 of 12 septic animals (42%) treated with CB1R antagonist after induction of anesthesia with pentobarbital. The data suggest that CB1R inhibition in combination with pentobarbital may increase the incidence of anesthetic-induced seizures in the case of sepsis.
authors.affiliation: Department of Anesthesiology and Intensive Care Medicine, Ernst Moritz Arndt University Greifswald, Greifswald, Germany.
authors.forename: Inga
authors.initials: I
authors.lastname: Küster
authors.forename: Rieke
authors.initials: R
authors.lastname: Kuschnereit
authors.forename: Melanie
authors.initials: M
authors.lastname: Kelly
authors.forename: Juan
authors.initials: J
authors.lastname: Zhou
authors.forename: Sara
authors.initials: S
authors.lastname: Whynot
authors.forename: Mandana
authors.initials: M
authors.lastname: Kianian
authors.forename: Orlando
authors.initials: O
authors.lastname: Hung
authors.forename: Romesh
authors.initials: R
authors.lastname: Shukla
authors.forename: Vladimir
authors.initials: V
authors.lastname: Cerny
authors.forename: Dragan
authors.initials: D
authors.lastname: Pavlovic
authors.forename: Christian
authors.initials: C
authors.lastname: Lehmann
mesh_terms: D000758:Anesthesia / Q000009:adverse effects*; D000818:Animals; D001095:Arachidonic Acids / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D004195:Disease Models, Animal; D004830:Epilepsy, Tonic-Clonic / Q000209:etiology* / Q000378:metabolism / Q000523:psychology; D006993:Hypnotics and Sedatives / Q000633:toxicity*; D008297:Male; D009025:Morpholines / Q000633:toxicity*; D010424:Pentobarbital / Q000633:toxicity*; D011720:Pyrazoles / Q000633:toxicity*; D051381:Rats; D011917:Rats, Inbred Lew; D043884:Receptor, Cannabinoid, CB1 / Q000819:agonists / Q000037:antagonists & inhibitors* / Q000378:metabolism; D018805:Sepsis / Q000150:complications* / Q000188:drug therapy* / Q000378:metabolism; D013997:Time Factors
chemical_list: D001095:Arachidonic Acids; C543264:Cnr1 protein, rat; D006993:Hypnotics and Sedatives; D009025:Morpholines; D011720:Pyrazoles; D043884:Receptor, Cannabinoid, CB1; C119325:arachidonyl-2-chloroethylamide; D010424:Pentobarbital; C109925:AM 281