title: A case of chromomycosis treated by surgical therapy combined with preceded oral administration of terbinafine to reduce the size of the lesion.
abstract: Chromomycosis is a chronic fungal disease of the skin and subcutaneous tissues caused by a group of dematiaceous black fungi. Small lesions can be removed with excision, but other cases are difficult to treat. We report a case of chromomycosis caused by Fonsecaea pedrosoi (F. pedrosoi). The case involved a 74-year-old man, who had noted a lesion on the back of the right thigh, that was gradually enlarging and reaching up to 30 cm in diameter, in 20-years. From microscopic examination, sclerotic cells were seen. We diagnosed this case as chromomycosis caused by F. pedrosoi on mycological examination. The patient was initially treated with oral terbinafine (250 mg/day) as the lesion was very large. After the 18 months treatment, the size of the lesion reduced to 1 cm, then the remaining lesion was excised.
authors.affiliation: Department of Dermatology, Tokai University School of Medicine, Isehara, Kanagawa, Japan. kana.m@is.icc.u-tokai.ac.jp
authors.forename: Kana
authors.initials: K
authors.lastname: Tamura
authors.forename: Takashi
authors.initials: T
authors.lastname: Matsuyama
authors.forename: Eiichiro
authors.initials: E
authors.lastname: Yahagi
authors.forename: Tomoko
authors.initials: T
authors.lastname: Kojima
authors.forename: Emiko
authors.initials: E
authors.lastname: Akasaka
authors.forename: Akio
authors.initials: A
authors.lastname: Kondo
authors.forename: Norihiro
authors.initials: N
authors.lastname: Ikoma
authors.forename: Tomotaka
authors.initials: T
authors.lastname: Mabuchi
authors.forename: Shiho
authors.initials: S
authors.lastname: Tamiya
authors.forename: Akira
authors.initials: A
authors.lastname: Ozawa
authors.forename: Takashi
authors.initials: T
authors.lastname: Mochizuki
mesh_terms: D000368:Aged; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001203:Ascomycota / Q000302:isolation & purification; D002862:Chromoblastomycosis / Q000188:drug therapy / Q000382:microbiology / Q000601:surgery; D003131:Combined Modality Therapy; D006801:Humans; D008297:Male; D009281:Naphthalenes / Q000008:administration & dosage / Q000627:therapeutic use*; D000077291:Terbinafine; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D009281:Naphthalenes; D000077291:Terbinafine