title: Determination of antimutagenic properties of apigenin-7-O-rutinoside, a flavonoid isolated from Mentha longifolia (L.) Huds. ssp. longifolia with yeast DEL assay.
abstract: Lamiaceae is an important plant family that has been investigated for its medicinal properties due to its large amounts of phenolic acids and flavonoids. Flavonoids have been shown to have antioxidant and antimutagenic activities in different test systems, but their certain mechanisms are still unclear. This study was designed to evaluate the mutagenic and antimutagenic activities of apigenin 7-O-rutinoside, a flavonoid isolated from Mentha longifolia (L.) Huds. ssp. longifolia. The possible antimutagenic potential of apigenin 7-O-rutinoside (A7R) was examined against mutagens ethyl methanesulfonate (EMS) and acridine (AC) in a eukaryotic cell system Saccharomyces cerevisiae RS112. The results showed that A7R has different inhibition rates against EMS and AC-induced mutagenicity. Thus, the properties of A7R are of great pharmacological importance and might be beneficial for reducing the risk of reactive oxygen species-related diseases.
authors.affiliation: Department of Biology, Ataturk University, Erzurum, Turkey.
authors.forename: Medine
authors.initials: M
authors.lastname: Gulluce
authors.forename: Furkan
authors.initials: F
authors.lastname: Orhan
authors.forename: Ahmet
authors.initials: A
authors.lastname: Adiguzel
authors.forename: Tugba
authors.initials: T
authors.lastname: Bal
authors.forename: Zuhal
authors.initials: Z
authors.lastname: Guvenalp
authors.forename: Lutfiye Omur
authors.initials: LO
authors.lastname: Dermirezer
mesh_terms: D000166:Acridines / Q000633:toxicity; D000704:Analysis of Variance; D016587:Antimutagenic Agents / Q000494:pharmacology*; D047310:Apigenin / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects*; D004121:Dimethyl Sulfoxide / Q000633:toxicity; D006027:Glycosides / Q000494:pharmacology*; D027541:Mentha / Q000737:chemistry*; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity; D012441:Saccharomyces cerevisiae / Q000166:cytology / Q000187:drug effects*
chemical_list: D000166:Acridines; D016587:Antimutagenic Agents; D006027:Glycosides; D009153:Mutagens; C111466:apigenin-7-O-rutinoside; D047310:Apigenin; D004121:Dimethyl Sulfoxide