title: Bromide-associated lower airway disease: a retrospective study of seven cats.
abstract: Seven cats were presented for mild-to-moderate cough and/or dyspnoea after starting bromide (Br) therapy for neurological diseases. The thoracic auscultation was abnormal in three cats showing increased respiratory sounds and wheezes. Haematology revealed mild eosinophilia in one cat. The thoracic radiographs showed bronchial patterns with peribronchial cuffing in most of them. Bronchoalveolar lavage performed in two cats revealed neutrophilic and eosinophilic inflammation. Histopathology conducted in one cat showed endogenous lipid pneumonia (EnLP). All cats improved with steroid therapy after Br discontinuation. Five cats were completely weaned off steroids, with no recurrence of clinical signs. In one cat, the treatment was discontinued despite persistent clinical signs. The cat presenting with EnLP developed secondary pneumothorax and did not recover. Br-associated lower airway disease can appear in cats after months of treatment and clinical improvement occurs only after discontinuing Br therapy.
authors.affiliation: CHV Fregis, Arcueil, France. coraliebertolani@gmail.com
authors.forename: Coralie
authors.initials: C
authors.lastname: Bertolani
authors.forename: Juan
authors.initials: J
authors.lastname: Hernandez
authors.forename: Eymeric
authors.initials: E
authors.lastname: Gomes
authors.forename: Laurent
authors.initials: L
authors.lastname: Cauzinille
authors.forename: Agnès
authors.initials: A
authors.lastname: Poujade
authors.forename: Alexandra
authors.initials: A
authors.lastname: Gabriel
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D001965:Bromides / Q000009:adverse effects* / Q000627:therapeutic use; D002371:Cat Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy*; D002415:Cats; D005260:Female; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D007249:Inflammation / Q000662:veterinary; D008297:Male; D011017:Pneumonia, Lipid / Q000662:veterinary; D011650:Pulmonary Alveoli / Q000473:pathology; D012129:Respiratory Function Tests / Q000662:veterinary; D012140:Respiratory Tract Diseases / Q000139:chemically induced / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D012189:Retrospective Studies
chemical_list: D000927:Anticonvulsants; D001965:Bromides; D007166:Immunosuppressive Agents