title: Anti-oncogenic potential of the eIF4E-binding proteins.
abstract: The eIF4E-binding proteins (4E-BPs) are inhibitors of protein synthesis that sequester the mRNA cap-binding protein eIF4E and consequently block cell growth and proliferation. In most tumors however, their inhibitory function is compromised by major oncogenic signaling pathways. Recently, thanks to the generation of mouse genetic models, considerable progress has been made in elucidating the involvement of 4E-BPs and their unique target, eIF4E, in the process of carcinogenesis. Increasing evidence indicates that an 'addiction' to protein synthesis emerges in cancer cells, highlighting the potential that 4E-BPs have as targets for therapeutics. In this review, we summarize the biochemical function, regulation and anti-oncogenic activity of the 4E-BPs.
authors.affiliation: INSERM UMR-1037, Université de Toulouse, Centre de Recherche en Cancérologie de Toulouse, Toulouse, France.
authors.forename: Y
authors.initials: Y
authors.lastname: Martineau
authors.forename: R
authors.initials: R
authors.lastname: Azar
authors.forename: C
authors.initials: C
authors.lastname: Bousquet
authors.forename: S
authors.initials: S
authors.lastname: Pyronnet
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000502:physiology*; D000818:Animals; D018797:Cell Cycle Proteins; D049109:Cell Proliferation; D002471:Cell Transformation, Neoplastic; D039561:Eukaryotic Initiation Factor-4E / Q000378:metabolism*; D039562:Eukaryotic Initiation Factor-4F / Q000378:metabolism; D039642:Eukaryotic Initiation Factors / Q000502:physiology*; D006801:Humans; D010750:Phosphoproteins / Q000502:physiology*; D010766:Phosphorylation; D014176:Protein Biosynthesis; D012097:Repressor Proteins
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D018797:Cell Cycle Proteins; C087000:EIF4EBP1 protein, human; C104151:EIF4EBP2 protein, human; D039561:Eukaryotic Initiation Factor-4E; D039562:Eukaryotic Initiation Factor-4F; D039642:Eukaryotic Initiation Factors; D010750:Phosphoproteins; D012097:Repressor Proteins