title: Impact of epidural analgesia on survival in patients undergoing complete cytoreductive surgery for ovarian cancer.
abstract: BACKGROUND
  Potential benefits of regional analgesia in reduction of cancer recurrence have been reported for breast and prostate cancer. The aim of this study was to evaluate the influence of regional analgesia on recurrence-free survival and overall survival in patients with advanced-stage ovarian cancer (ASOC) following complete cytoreduction.
  
  
  METHODS
  This is a retrospective study of 104 patients who had undergone complete cytoreduction for ASOC between 01/2007 and 12/2009: 51 with patient controlled epidural analgesia (PCEA) and 53 without PCEA.
  
  
  RESULTS
  No significant difference was found between the two groups in terms of overall survival, while there was a trend in favour of PCEA for disease free survival.
  
  
  CONCLUSIONS
  In our study, regional analgesia had no clear impact on cancer recurrence. More studies on this subject are warranted in order to determine the possible impact of regional analgesia on ASOC.
authors.affiliation: Department of Surgery, Institut Gustave Roussy, Villejuif, France.
authors.forename: Perrine
authors.initials: P
authors.lastname: Capmas
authors.forename: Valérie
authors.initials: V
authors.lastname: Billard
authors.forename: Sebastien
authors.initials: S
authors.lastname: Gouy
authors.forename: Catherine
authors.initials: C
authors.lastname: Lhommé
authors.forename: Patricia
authors.initials: P
authors.lastname: Pautier
authors.forename: Philippe
authors.initials: P
authors.lastname: Morice
authors.forename: Catherine
authors.initials: C
authors.lastname: Uzan
mesh_terms: D000328:Adult; D015360:Analgesia, Epidural; D005260:Female; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000601:surgery*; D012189:Retrospective Studies