title: Bioactive anti-inflammatory coating for chronic neural electrodes.
abstract: Chronic electrodes are widely used for brain degenerative and psychiatric diseases such as Parkinson's disease,major depression, and obsessive-compulsive disorder, and for neuronal prosthesis. Brain immune reaction to electrodes in the form of glial scar encapsulates the electrode and reduces the efﬁcacy of deep brain stimulation and neuronal prosthesis.State-of-the-art strategies for improving brain–electrode interface use passive protein coating to "camouﬂage" the electrode from the immune system. In this study, we actively reduced the brain immune reaction to the chronic electrodes using immune suppressing protein, that is, interleukin (IL)-1 receptor antagonist. IL-1 receptor antagonist-coated electrodes and non coated electrodes were chronically implanted in rats. An additional group of rats was chronically implanted with IL-1 receptor antagonist- and laminin-coated electrodes (as passive protein). Examination of glial scaring 1 and 4 weeks after implantation indicated a signiﬁcant reduction in the amount of glial scar in the vicinity of the IL-1 receptor antagonist-coated electrode in comparison to both non coated electrode and laminin-coated electrodes. The results strongly suggest that active immune suppressing protein reduces the level of immune reaction to chronic electrodes already after 1 week after implantation and generates less immune reaction than passive protein coating [corrected].
authors.affiliation: Psychobiology Research Unit, Department of Psychology, Tel-Aviv University, Tel-Aviv 69978, Israel. aryataub@post.tau.ac.il
authors.forename: Aryeh H
authors.initials: AH
authors.lastname: Taub
authors.forename: Roni
authors.initials: R
authors.lastname: Hogri
authors.forename: Ari
authors.initials: A
authors.lastname: Magal
authors.forename: Matti
authors.initials: M
authors.lastname: Mintz
authors.forename: Yosi
authors.initials: Y
authors.lastname: Shacham-Diamand
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000494:pharmacology; D004566:Electrodes; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D007150:Immunohistochemistry; D053590:Interleukin 1 Receptor Antagonist Protein / Q000008:administration & dosage* / Q000494:pharmacology; D009474:Neurons / Q000166:cytology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000893:Anti-Inflammatory Agents; D005904:Glial Fibrillary Acidic Protein; D053590:Interleukin 1 Receptor Antagonist Protein