title: Nephrotic syndrome associated with toxoplasmosis: report of seven cases.
abstract: The concomitance of nephrotic syndrome and acute infection by Toxoplasma gondii is a rare occurrence in humans. In this paper seven cases of children, ranging from 11 months to 7 year-old, with concomitant nephrotic syndrome and asymptomatic acute T. gondii infection are reported. In one of those patients only the administration of anti-Toxoplasma therapy was enough to control the clinical and laboratory manifestations of the disease. In the other patients it was necessary to introduce corticosteroids or other immunosuppressant drugs. Three patients had complete clinical and laboratory improvement and the remaining showed only a partial response.
authors.affiliation: Pediatric Department, Medical School of Santa Casa, São Paulo, SP, Brazil.
authors.forename: Julio
authors.initials: J
authors.lastname: Toporovski
authors.forename: Simone
authors.initials: S
authors.lastname: Romano
authors.forename: Suzana
authors.initials: S
authors.lastname: Hartmann
authors.forename: Wanda
authors.initials: W
authors.lastname: Benini
authors.forename: Pedro Paulo
authors.initials: PP
authors.lastname: Chieffi
mesh_terms: D000208:Acute Disease; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D002955:Leucovorin / Q000627:therapeutic use; D008297:Male; D009404:Nephrotic Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000469:parasitology*; D011739:Pyrimethamine / Q000627:therapeutic use; D013411:Sulfadiazine / Q000627:therapeutic use; D014123:Toxoplasmosis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy
chemical_list: D000305:Adrenal Cortex Hormones; D013411:Sulfadiazine; D002955:Leucovorin; D011739:Pyrimethamine