title: Pityriasis rosea-like eruption associated with clozapine: a case report.
abstract: Adverse cutaneous drug reactions (ACDRs) are common in clinical practice and occur in about 5% of antipsychotic-treated patients. Most ACDRs are benign, but a small percentage of them are serious and life threatening. Pityriasis rosea (PR)-like eruption is a common cutaneous adverse reaction related to many drugs. Clozapine, a complex neurotransmitter receptor-binding in antipsychotic agent, is usually used for treatment-resistant schizophrenia. Clozapine-related ACDRs have been reported frequently, but clozapine-induced PR-like eruption has been reported once in the literature. We report a 54-year-old male patient with chronic schizophrenia who had received clozapine for 28 days and developed generalized skin rashes, high fever, and elevated values in liver function tests. His clozapine was immediately discontinued. He received acute managements with steroid and antihistamine, and his symptoms were relieved after treatment. This case report can be used to remind clinicians of keeping in mind the potential of clozapine-associated ACDRs.
authors.affiliation: Department of Psychiatry, Taipei Medical University-Wan Fang Medical Center and School of Medicine, Taipei Medical University, Taipei, Taiwan.
authors.forename: Ya-Wen
authors.initials: YW
authors.lastname: Lai
authors.forename: Che-Yi
authors.initials: CY
authors.lastname: Chou
authors.forename: Winston W
authors.initials: WW
authors.lastname: Shen
authors.forename: Mong-Liang
authors.initials: ML
authors.lastname: Lu
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D014150:Antipsychotic Agents / Q000009:adverse effects*; D003024:Clozapine / Q000009:adverse effects*; D005334:Fever / Q000139:chemically induced; D006633:Histamine Antagonists / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D017515:Pityriasis Rosea / Q000139:chemically induced* / Q000188:drug therapy; D012559:Schizophrenia / Q000188:drug therapy*
chemical_list: D000305:Adrenal Cortex Hormones; D014150:Antipsychotic Agents; D006633:Histamine Antagonists; D003024:Clozapine