title: Parvovirus 4 infection and clinical outcome in high-risk populations.
abstract: Parvovirus 4 (PARV4) is a DNA virus frequently associated with human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infections, but its clinical significance is unknown. We studied the prevalence of PARV4 antibodies in 2 cohorts of HIV- and HCV-infected individuals (n = 469) and the correlations with disease status. We found that PARV4 infection frequently occurred in individuals exposed to bloodborne viruses (95% in HCV-HIV coinfected intravenous drug users [IDUs]). There were no correlations between PARV4 serostatus and HCV outcomes. There was, however, a significant association with early HIV-related symptoms, although because this was tightly linked to both HCV status and clinical group (IDU), the specific role of PARV4 is not yet clear.
authors.affiliation: Nuffield Department of Medicine, Peter Medawar Building for Pathogen Research, University of Oxford, Oxford. ruth.simmons@ndm.ox.ac.uk
authors.forename: Ruth
authors.initials: R
authors.lastname: Simmons
authors.forename: Colin
authors.initials: C
authors.lastname: Sharp
authors.forename: C Patrick
authors.initials: CP
authors.lastname: McClure
authors.forename: Janine
authors.initials: J
authors.lastname: Rohrbach
authors.forename: Helen
authors.initials: H
authors.lastname: Kovari
authors.forename: Eleni
authors.initials: E
authors.lastname: Frangou
authors.forename: Peter
authors.initials: P
authors.lastname: Simmonds
authors.forename: Will
authors.initials: W
authors.lastname: Irving
authors.forename: Andri
authors.initials: A
authors.lastname: Rauch
authors.forename: Paul
authors.initials: P
authors.lastname: Bowness
authors.forename: Paul
authors.initials: P
authors.lastname: Klenerman
mesh_terms: D000914:Antibodies, Viral / Q000097:blood*; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D008297:Male; D010322:Parvoviridae Infections / Q000453:epidemiology* / Q000276:immunology; D016036:Seroepidemiologic Studies
chemical_list: D000914:Antibodies, Viral