title: Antiangiogenic polyketides from Peperomia dindygulensis Miq.
abstract: Two new polyketides: 2Z-(heptadec-12-enyl)-4-hydroxy-3,4,7,8-tetrahydro-2H-chromen-5(6H)-one (1) and 2-(heptadec-12-enyl)-5-hydroxy-5,6,7,8-tetrahydrochromen- 4-one (2), together with eleven known compounds: 4-hydroxy-2-[(3,4-methylenedioxy- phenyl)tridecanoyl] cyclohexane-1,3-dione (3), oleiferinone (4), 4-hydroxy-2-[(3,4- methylenedioxyphenyl)undecanoyl]cyclohexane-1,3-dione (5), 4-hydroxy-2-[(11-phenyl- undecanoyl)cyclohexane-1,3-dione (6), proctorione C (7), surinone C (8), 5-hydroxy- 7,8,4'-trimethoxyflavone (9), 5-hydroxy-7,8,3',4'-tetramethoxyflavone (10), 5-hydroxy- 7,3',4'-trimethoxyflavone (11), 5,8-dihydroxy-7,3',4'-trimethoxyflavone (12) and cepharanone B (13) were isolated from the whole plant of Peperomia dindygulensis Miq. Their structures were elucidated by spectroscopic methods, including 2D-NMR techniques. Compounds 2, 3, 5 and 8 inhibited human umbilical vein endothelial cell (HUVEC) proliferation and compounds 5 and 8 sharply suppressed HUVEC tube formation.
authors.affiliation: Department of Traditional Chinese Medicine, Shanghai Institute of Pharmaceutical Industry, Shanghai 200040, China.
authors.forename: Qi-Wei
authors.initials: QW
authors.lastname: Wang
authors.forename: De-Hong
authors.initials: DH
authors.lastname: Yu
authors.forename: Meng-Gan
authors.initials: MG
authors.lastname: Lin
authors.forename: Mei
authors.initials: M
authors.lastname: Zhao
authors.forename: Wen-Jun
authors.initials: WJ
authors.lastname: Zhu
authors.forename: Qin
authors.initials: Q
authors.lastname: Lu
authors.forename: Gui-Xiu
authors.initials: GX
authors.lastname: Li
authors.forename: Chao
authors.initials: C
authors.lastname: Wang
authors.forename: Yi-Fang
authors.initials: YF
authors.lastname: Yang
authors.forename: Xue-Mei
authors.initials: XM
authors.lastname: Qin
authors.forename: Chao
authors.initials: C
authors.lastname: Fang
authors.forename: Hong-Zhuan
authors.initials: HZ
authors.lastname: Chen
authors.forename: Guo-Hong
authors.initials: GH
authors.lastname: Yang
mesh_terms: D020533:Angiogenesis Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D061307:Human Umbilical Vein Endothelial Cells / Q000187:drug effects; D006801:Humans; D019906:Nuclear Magnetic Resonance, Biomolecular; D036941:Peperomia / Q000737:chemistry; D061065:Polyketides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D020533:Angiogenesis Inhibitors; D061065:Polyketides