title: Migraine in cervical artery dissection and ischemic stroke patients.
abstract: OBJECTIVE
  Several small to medium-sized studies indicated a link between cervical artery dissection (CeAD) and migraine. Migrainous CeAD patients were suggested to have different clinical characteristics compared to nonmigraine CeAD patients. We tested these hypotheses in the large Cervical Artery Dissection and Ischemic Stroke Patients (CADISP) population.
  
  
  METHODS
  A total of 968 CeAD patients and 653 patients with an ischemic stroke of a cause other than CeAD (non-CeAD IS) were recruited. CeAD patients with stroke (CeAD(stroke), n = 635) were compared with non-CeAD IS patients regarding migraine, clinical characteristics, and outcome. CeAD patients with and without migraine were compared in terms of clinical characteristics and outcome.
  
  
  RESULTS
  Migraine was more common among CeAD(stroke) patients compared to non-CeAD IS patients (35.7 vs 27.4%, p = 0.003). The difference was mainly due to migraine without aura (20.2 vs 11.2%, p < 0.001). There were no differences in prevalence of strokes, arterial distribution, or other clinical or prognostic features between migrainous and nonmigrainous CeAD patients.
  
  
  CONCLUSIONS
  Migraine without aura is more common among CeAD(stroke) patients compared to non-CeAD IS patients. The mechanisms and possible causative link remain to be proved. Although CeAD is often complicated by stroke, our data do not support increased risk of stroke in migrainous CeAD patients.
authors.affiliation: Department of Neurology, Helsinki University Central Hospital, Helsinki, Finland. tiina.m.metso@helsinki.fi
authors.forename: T M
authors.initials: TM
authors.lastname: Metso
authors.forename: T
authors.initials: T
authors.lastname: Tatlisumak
authors.forename: S
authors.initials: S
authors.lastname: Debette
authors.forename: J
authors.initials: J
authors.lastname: Dallongeville
authors.forename: S T
authors.initials: ST
authors.lastname: Engelter
authors.forename: P A
authors.initials: PA
authors.lastname: Lyrer
authors.forename: V
authors.initials: V
authors.lastname: Thijs
authors.forename: A
authors.initials: A
authors.lastname: Bersano
authors.forename: S
authors.initials: S
authors.lastname: Abboud
authors.forename: D
authors.initials: D
authors.lastname: Leys
authors.forename: C
authors.initials: C
authors.lastname: Grond-Ginsbach
authors.forename: M
authors.initials: M
authors.lastname: Kloss
authors.forename: E
authors.initials: E
authors.lastname: Touzé
authors.forename: A
authors.initials: A
authors.lastname: Pezzini
authors.forename: A J
authors.initials: AJ
authors.lastname: Metso
mesh_terms: D000328:Adult; D002545:Brain Ischemia / Q000150:complications / Q000453:epidemiology*; D020215:Carotid Artery, Internal, Dissection / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D015995:Prevalence; D011379:Prognosis; D012307:Risk Factors; D020521:Stroke / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D020217:Vertebral Artery Dissection / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*