title: Multivalent dual pharmacology muscarinic antagonist and β₂ agonist (MABA) molecules for the treatment of COPD.
authors.affiliation: Department of Medicinal Chemistry, Theravance, Inc., South San Francisco, CA, USA.
authors.forename: Adam D
authors.initials: AD
authors.lastname: Hughes
authors.forename: Alexander
authors.initials: A
authors.lastname: McNamara
authors.forename: Tod
authors.initials: T
authors.lastname: Steinfeld
mesh_terms: D000280:Administration, Inhalation; D058666:Adrenergic beta-2 Receptor Agonists / Q000494:pharmacology* / Q000627:therapeutic use; D000588:Amines / Q000737:chemistry; D000818:Animals; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use*; D015195:Drug Design; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006801:Humans; D015394:Molecular Structure; D018727:Muscarinic Antagonists / Q000737:chemistry* / Q000494:pharmacology*; D029424:Pulmonary Disease, Chronic Obstructive / Q000188:drug therapy*; D043585:Receptor, Muscarinic M2 / Q000819:agonists
chemical_list: D058666:Adrenergic beta-2 Receptor Agonists; D000588:Amines; D001993:Bronchodilator Agents; D018727:Muscarinic Antagonists; D043585:Receptor, Muscarinic M2