title: [Aggressive fibromatosis of the head and neck (A report of two cases and literature review)].
abstract: To evaluate the clinic manifestation, pathologic behavior, therapy and prognosis of rare aggressive fibromatosis in the head and neck.
  
  
  
  Two cases of aggressive fibromatosis were analyzed and relevant literatures were reviewed.
  
  
  
  Aggressive fibromatosis was characterized as infiltrative, locally aggressive and tended to recur after surgical resection. Pathology showed fibroblastic monoclonal proliferation. Fibromatosis was composed of well-differentiated fibroblasts and myofibroblasts, lacking cytological features of malignancy and scanty or absent mitotic activity. Complete surgical excision of aggressive fibromatosis was considered to be the only effective method of cure by most authorities. Chemotherapy and radiotherapy can be used together with surgery in recurrence or unsatisfactory surgical margin. In our study, one patient recurred after the first operation, and after another operation, the patient did not recur after 6 months follow up, and the other one did not recur after 6 months follow up.
  
  
  
  The diagnosis of aggressive fibromatosis depended on pathological examination. Radical removal was an important way to reduce recurrence rate. Radiation therapy and chemotherapy can be used as adjuvant therapy in patients with recurrent or unresectable or inoperable disease.
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, West China Hospital, Sichuan University, Chengdu, 610041, China.
authors.forename: Dan
authors.initials: D
authors.lastname: Lü
authors.forename: Liyan
authors.initials: LY
authors.lastname: Yue
authors.forename: Daibo
authors.initials: DB
authors.lastname: Li
authors.forename: Heng
authors.initials: H
authors.lastname: Zeng
authors.forename: Hui
authors.initials: H
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D005260:Female; D018222:Desmoid Tumors / Q000175:diagnosis / Q000601:surgery; D006258:Head and Neck Neoplasms / Q000175:diagnosis / Q000601:surgery; D006801:Humans; D008875:Middle Aged