title: Association between the markers of FIRS and the morphologic alterations in the liver of neonates autopsied in the perinatal period.
abstract: Markers of fetal inflammatory response syndrome (FIRS) can influence the morphologic alterations in liver of autopsied neonates. The IL-6, TNF-α, and C-reactive protein (CRP) expression in liver fragments were marked by immunohistochemistry and the intensity of steatosis, percentage of fibrosis, and the number of foci of extramedullary erythropoiesis were evaluated. The degree of steatosis correlated positively with IL-6 (p = 0.06), positively with CRP (p ≤ 0.001), and negatively with TNF-α (p = 0.06). The collagen percentage correlated positively with IL-6 (p = 0.055) and positively with TNF-α (p ≤ 0.001). Erythropoiesis correlated positively with IL-6 (p ≤ 0.001) and negatively with CRP (p = 0.00754). The analyzed markers of FIRS have an important role in triggering hepatic morphologic alterations.
authors.affiliation: Triângulo Mineiro Federal University, Biological Sciences Department, General Pathology Division, Uberaba, Brazil.
authors.forename: Lívia Helena
authors.initials: LH
authors.lastname: de Morais Pereira
authors.forename: Janaínna Grazielle
authors.initials: JG
authors.lastname: Pacheco Olegário
authors.forename: Laura Penna
authors.initials: LP
authors.lastname: Rocha
authors.forename: Camila Souza
authors.initials: CS
authors.lastname: de Oliveira Guimarães
authors.forename: Fernando Silva
authors.initials: FS
authors.lastname: Ramalho
authors.forename: Marlene Antônia
authors.initials: MA
authors.lastname: dos Reis
authors.forename: Rosana Rosa
authors.initials: RR
authors.lastname: Miranda Corrêa
mesh_terms: D001344:Autopsy; D015415:Biomarkers / Q000032:analysis; D002097:C-Reactive Protein / Q000032:analysis / Q000096:biosynthesis; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000378:metabolism* / Q000473:pathology*; D015850:Interleukin-6 / Q000032:analysis / Q000096:biosynthesis; D008099:Liver / Q000378:metabolism* / Q000473:pathology*; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism / Q000473:pathology; D013577:Syndrome; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis / Q000096:biosynthesis
chemical_list: D015415:Biomarkers; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein