title: [Systematic analysis and metabolic regulation of physiological functions for lactic acid bacteria--a review].
abstract: As cell factories, lactic acid bacteria are widely used in food, agriculture, medicine and other industries, and play a great role in industrial processes. However, lactic acid bacteria encounter various environmental stresses both in industrial processes and in the gastrointestinal tract, which impair their physiological functions and food manufacture efficiency. Recently, the development of metabolic engineering and system biology brings unprecedented opportunity for the physiological modification of lactic acid bacteria. In this review, we addresses the progress of lactic acid bacterium system biology, and based on this, the metabolic engineering strategies for manipulating and optimizing lactic acid bacteria physiological function were summarized.
authors.affiliation: State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China. wuchongde@163.com
authors.forename: Chongde
authors.initials: C
authors.lastname: Wu
authors.forename: Juan
authors.initials: J
authors.lastname: Zhang
authors.forename: Liming
authors.initials: L
authors.lastname: Liu
mesh_terms: D007778:Lactobacillus / Q000502:physiology*; D017045:Lactococcus / Q000502:physiology*; D060847:Metabolic Engineering; D049490:Systems Biology