title: Clinical comparison of the Bactec Mycosis IC/F, BacT/Alert FA, and BacT/Alert FN blood culture vials for the detection of candidemia.
abstract: The present study analyzed the performance of Bactec Mycosis IC/F, BacT/Alert FA, and BacT/Alert FN vials in detection and time to detection (TTD) of Candida spp. in 179 simultaneous blood cultures. The Mycosis IC/F, BacT/Alert FA, and BacT/Alert FN vials could detect Candida spp. in 144 (80.45%) of 179, 149 (83.24%) of 179, and 8 (4.47%) of 179 samples, respectively. With the presence of antifungal therapy, the numbers of positive vials were higher in BacT/Alert FA compared to Mycosis IC/F, 87/99 versus 73/99, respectively (P < 0.05). TTD (SD) for C. albicans was shorter in Mycosis IC/F than in BacT/Alert FA vials without antifungal therapy, 20.89 (9.33) versus 28.26 (9.77), respectively (P < 0.01). The detection of Candida spp., with concomitant bacteremia, was higher in Mycosis IC/F than in BacT/Alert FA vials, 28/30 and 19/30, respectively (P = 0.01). The present data show that the use of Bactec Mycosis IC/F together with BacT/Alert FA vials might improve the detection of Candida spp.
authors.affiliation: Division of Clinical Microbiology F 72, Karolinska Institutet, Karolinska University Hospital, Huddinge, Stockholm, Sweden.
authors.forename: Eva-Lena
authors.initials: EL
authors.lastname: Ericson
authors.forename: Lena
authors.initials: L
authors.lastname: Klingspor
authors.forename: Måns
authors.initials: M
authors.lastname: Ullberg
authors.forename: Volkan
authors.initials: V
authors.lastname: Ozenci
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D016470:Bacteremia / Q000097:blood / Q000382:microbiology; D002175:Candida / Q000302:isolation & purification*; D058387:Candidemia / Q000097:blood* / Q000188:drug therapy / Q000382:microbiology; D060085:Coinfection / Q000097:blood / Q000188:drug therapy; D003470:Culture Media; D006801:Humans; D057230:Limit of Detection; D016533:Mycological Typing Techniques / Q000295:instrumentation* / Q000379:methods*
chemical_list: D000935:Antifungal Agents; D003470:Culture Media