title: Biocompatible zwitterionic sulfobetaine copolymer-coated mesoporous silica nanoparticles for temperature-responsive drug release.
abstract: A novel nanocontainer, which could regulate the release of payloads, has been successfully fabricated by attaching zwitterionic sulfobetaine copolymer onto the mesoporous silica nanoparticles (MSNs). RAFT polymerization is employed to prepare the hybrid poly(2-(dimethylamino)ethyl methacrylate)-coated MSNs (MSN-PDMAEMA). Subsequently, the tertiary amine groups in PDMAEMA are quaternized with 1,3-propanesultone to get poly(DMAEMA-co-3-dimethyl(methacryloyloxyethyl)ammonium propanesulfonate)-coated MSNs [MSN-Poly(DMAEMA-co-DMAPS)]. The zwitterionic PDMAPS component endows the nanocarrier with biocompatibility, and the PDMAEMA component makes the copolymer shell temperature-responsive. Controlled release of loaded rhodamine B has been achieved in the saline solutions.
authors.affiliation: CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, P R China.
authors.forename: Jiao-Tong
authors.initials: JT
authors.lastname: Sun
authors.forename: Zhi-Qiang
authors.initials: ZQ
authors.lastname: Yu
authors.forename: Chun-Yan
authors.initials: CY
authors.lastname: Hong
authors.forename: Cai-Yuan
authors.initials: CY
authors.lastname: Pan
mesh_terms: D001622:Betaine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D006367:HeLa Cells; D006801:Humans; D008689:Methacrylates / Q000737:chemistry; D053769:Nanocapsules / Q000737:chemistry* / Q000633:toxicity / Q000648:ultrastructure; D009757:Nylons / Q000737:chemistry; D058105:Polymerization; D011109:Polymethacrylic Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D012235:Rhodamines / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry*; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature
chemical_list: D003692:Delayed-Action Preparations; D008689:Methacrylates; D053769:Nanocapsules; D009757:Nylons; D011109:Polymethacrylic Acids; D012235:Rhodamines; C407037:poly(2-(dimethylamino)ethyl methacrylate); D001622:Betaine; D012822:Silicon Dioxide; C483727:sulfobetaine; C029773:rhodamine B