title: Asymmetrical dimethylarginine levels on the implantation success of in vitro fertilization and embryo transfer.
abstract: The aim of this study was to evaluate the level of asymmetrical dimethylarginine (ADMA) levels before gonadotrophine treatment and on the day of oocytes retrieval in order to determine whether ADMA can be used as a predictive marker for implantation success in in vitro fertilization (IVF) cycles. Forty-four unexplained infertile patients were included in the study. Controlled ovarian hyperstimulation was performed using the recombinant follicle-stimulating hormone (FSH) with the standard long protocol for all patients. ADMA and E2 were measured at the beginning of the ovulation induction and on oocyte retrieval day. The primary outcome was the difference in ADMA levels in implantation positive and implantation negative women. At the beginning of the ovulation induction, the mean ADMA levels were 1553 μmol/L and 1.464 μmol/L in the implantation positive and negative groups, respectively. There was no statistically significant difference between groups (p: 0.90). On the day of oocyte retrieval, the mean ADMA levels were 1173 μmol/L and 1170 μmol/L in the implantation positive and negative groups, respectively. There was no statistically significant difference between groups (p: 0.97). In conclusion, ADMA levels before gonadotrophine treatment and the day of oocytes retrieval cannot be used as a predictive marker for implantation success in IVF cycles.
authors.affiliation: Gulhane Military Medical Academy and Medical School, Department of Obstetrics and Gynaecology, Ankara, Turkey. drugurkeskin@gmail.com
authors.forename: Uğur
authors.initials: U
authors.lastname: Keskin
authors.forename: Ümit
authors.initials: Ü
authors.lastname: Göktolga
authors.forename: Erdinç
authors.initials: E
authors.lastname: Çakir
authors.forename: Seyit T
authors.initials: ST
authors.lastname: Ceyhan
authors.forename: Cihangir M
authors.initials: CM
authors.lastname: Ercan
authors.forename: Iskender
authors.initials: I
authors.lastname: Baser
mesh_terms: D000328:Adult; D001120:Arginine / Q000031:analogs & derivatives* / Q000097:blood; D015415:Biomarkers / Q000097:blood; D004624:Embryo Transfer; D004958:Estradiol / Q000097:blood; D005260:Female; D005300:Fertility Agents, Female / Q000494:pharmacology; D005307:Fertilization in Vitro; D043373:Follicle Stimulating Hormone, Human / Q000494:pharmacology; D006801:Humans; D007247:Infertility, Female / Q000097:blood / Q000378:metabolism / Q000628:therapy*; D019001:Nitric Oxide Synthase / Q000378:metabolism; D054315:Oocyte Retrieval; D010062:Ovulation Induction; D011247:Pregnancy; D018873:Pregnancy Rate; D011994:Recombinant Proteins / Q000494:pharmacology; D055815:Young Adult
chemical_list: D015415:Biomarkers; D005300:Fertility Agents, Female; D043373:Follicle Stimulating Hormone, Human; D011994:Recombinant Proteins; C487735:dimethylarginine; C571801:follitropin alfa; D004958:Estradiol; D001120:Arginine; D019001:Nitric Oxide Synthase