title: Myocardial structure and matrix metalloproteinases.
abstract: Metalloproteinases (MMPs) are enzymes which enhance proteolysis of extracellular matrix proteins. The pathophysiologic and prognostic role of MMPs has been demonstrated in numerous studies. The present review covers a wide a range of topics with regards to MMPs structural and functional properties, as well as their role in myocardial remodeling in several cardiovascular diseases. Moreover, the clinical and therapeutic implications from their assessment are highlighted.
authors.affiliation: 1st Cardiology Department, Hippokrateion Hospital, Athens Medical School, Athens, Greece. caggeli@otenet.gr
authors.forename: C
authors.initials: C
authors.lastname: Aggeli
authors.forename: P
authors.initials: P
authors.lastname: Pietri
authors.forename: I
authors.initials: I
authors.lastname: Felekos
authors.forename: L
authors.initials: L
authors.lastname: Rautopoulos
authors.forename: K
authors.initials: K
authors.lastname: Toutouzas
authors.forename: E
authors.initials: E
authors.lastname: Tsiamis
authors.forename: C
authors.initials: C
authors.lastname: Stefanadis
mesh_terms: D002318:Cardiovascular Diseases / Q000201:enzymology / Q000378:metabolism; D005109:Extracellular Matrix / Q000201:enzymology / Q000378:metabolism; D006801:Humans; D020782:Matrix Metalloproteinases / Q000737:chemistry / Q000378:metabolism*; D009206:Myocardium / Q000201:enzymology* / Q000378:metabolism; D013329:Structure-Activity Relationship; D020257:Ventricular Remodeling
chemical_list: D020782:Matrix Metalloproteinases