title: Placental pathology and long-term neurodevelopment of very preterm infants.
abstract: OBJECTIVE
  The objective of the study was to compare neonatal morbidity and long-term neurodevelopmental outcome between very preterm infants with placental underperfusion and very preterm infants with histological chorioamnionitis.
  
  
  METHODS
  We measured the mental and motor development at age 2 and 7 years in 51 very preterm infants with placental underperfusion and 21 very preterm infants with histological chorioamnionitis.
  
  
  RESULTS
  At 2 years, very preterm infants with placental underperfusion had poorer mental development than very preterm infants with histological chorioamnionitis (mean [SD] 90.8 [18.3] vs 104.1 [17.2], adjusted d = 1.12, P = .001). Motor development was not different between both groups (92.8 [17.2] vs 96.8 [8.7], adjusted d = 0.52, P = .12). At 7 years, large, although nonsignificant, effects were found for better mental and motor development and fewer behavioral problems in infants with histological chorioamnionitis.
  
  
  CONCLUSIONS
  Placental pathology contributes to variance in mental development at 2 years and should be taken into account when evaluating neurodevelopmental outcome of very preterm infants.
authors.affiliation: Division of Neonatology, Department of Pediatrics, VU University Medical Center, Amsterdam, The Netherlands.
authors.forename: Elvira O G
authors.initials: EO
authors.lastname: van Vliet
authors.forename: Jorrit F
authors.initials: JF
authors.lastname: de Kieviet
authors.forename: J Patrick
authors.initials: JP
authors.lastname: van der Voorn
authors.forename: Jasper V
authors.initials: JV
authors.lastname: Been
authors.forename: Jaap
authors.initials: J
authors.lastname: Oosterlaan
authors.forename: Ruurd M
authors.initials: RM
authors.lastname: van Elburg
mesh_terms: D002648:Child; D002653:Child Behavior Disorders / Q000209:etiology; D002657:Child Development; D002675:Child, Preschool; D002821:Chorioamnionitis / Q000401:mortality; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000209:etiology; D016015:Logistic Models; D008297:Male; D010927:Placental Insufficiency / Q000401:mortality; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects / Q000209:etiology*; D011581:Psychological Tests; D011597:Psychomotor Performance