title: [Management of metastatic castration-resistant prostate cancer following docetaxel].
abstract: Abiraterone acetate and cabazitaxel have shown an overall survival benefit in patients with metastatic castration-resistant prostate cancer following docetaxel failure. Both have been approved in this indication. The search, follow-up and characterisation of circulating tumor cells should help for the response evaluation and the choice between the two treatments. Recently, alpharadin (radium-223 chloride) has demonstrated also an overall survival advantage in a large phase III trial. Other hormone therapies as MDV3100 or TAK700 are very promising. In undifferentiated cancers with neuroendocrine features, etoposide and platinum salts combinations have shown low efficiency.
authors.affiliation: Institut Curie, département d'oncologie médicale, 26, rue d'Ulm, 75005 Paris, France. philippe.beuzeboc@curie.net
authors.forename: Philippe
authors.initials: P
authors.lastname: Beuzeboc
authors.forename: Stanislas
authors.initials: S
authors.lastname: Ropert
authors.forename: François
authors.initials: F
authors.lastname: Goldwasser
authors.forename: Marc
authors.initials: M
authors.lastname: Zerbib
mesh_terms: D000069501:Abiraterone Acetate; D000726:Androgen Antagonists / Q000627:therapeutic use*; D000730:Androstadienes / Q000627:therapeutic use; D020533:Angiogenesis Inhibitors / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001549:Benzamides; D000077143:Docetaxel; D006801:Humans; D008297:Male; D009570:Nitriles; D009919:Orchiectomy; D010669:Phenylthiohydantoin / Q000031:analogs & derivatives / Q000627:therapeutic use; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000098:blood supply / Q000188:drug therapy*; D011868:Radioisotopes / Q000627:therapeutic use; D011883:Radium / Q000627:therapeutic use; D043823:Taxoids / Q000627:therapeutic use; D017211:Treatment Failure
chemical_list: D000726:Androgen Antagonists; D000730:Androstadienes; D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D001549:Benzamides; D009570:Nitriles; D011868:Radioisotopes; D043823:Taxoids; D000077143:Docetaxel; D010669:Phenylthiohydantoin; C552428:cabazitaxel; C540278:enzalutamide; D000069501:Abiraterone Acetate; C581106:radium Ra 223 dichloride; D011883:Radium