title: Multiple topologies from glycopolypeptide-dendron conjugate self-assembly: nanorods, micelles, and organogels.
abstract: Glycopolypeptides (GPs) were synthesized by ring-opening polymerization of glycosylated N-carboxyanhydride monomer and attached to hydrophobic dendrons at one chain end by "click" reaction to obtain amphiphilic anisotropic macromolecules. We show that by varying polypeptide chain length and dendron generation, an organogel was obtained in dimethylsulfoxide, while nanorods and micellar aggregates were observed in aqueous solutions. Assemblies in water were characterized by electron microscopy and dye encapsulation. Secondary structure of the GP chain was shown to affect the morphology, whereas the chain length of the poly(ethylene glycol) linker between the GP and dendron did not alter rod-like assemblies. Bioactive surface chemistry of these assemblies displaying carbohydrate groups was demonstrated by interaction of mannose-functionalized nanorods with ConA.
authors.affiliation: CReST Chemical Engineering Division, National Chemical Laboratory, Pune 411008, India.
authors.forename: Debasis
authors.initials: D
authors.lastname: Pati
authors.forename: Nagendra
authors.initials: N
authors.lastname: Kalva
authors.forename: Soumen
authors.initials: S
authors.lastname: Das
authors.forename: Guruswamy
authors.initials: G
authors.lastname: Kumaraswamy
authors.forename: Sayam
authors.initials: S
authors.lastname: Sen Gupta
authors.forename: Ashootosh V
authors.initials: AV
authors.lastname: Ambade
mesh_terms: D057930:Click Chemistry; D003208:Concanavalin A / Q000378:metabolism; D050091:Dendrimers / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D006020:Glycopeptides / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D008358:Mannose / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D008823:Micelles; D043942:Nanotubes / Q000737:chemistry* / Q000648:ultrastructure
chemical_list: D050091:Dendrimers; D006020:Glycopeptides; D008823:Micelles; D003208:Concanavalin A; D008358:Mannose