title: Verbal learning and memory and their associations with brain morphology and illness course in schizophrenia spectrum psychoses.
abstract: The California Verbal Learning Test and structural brain imaging were administered to 57 subjects with schizophrenia spectrum disorders and 94 controls in a general population sample. Cases had lower semantic cluster scores. Poorer verbal memory strategies were associated with longer duration of illness and heavier use of antipsychotic medication. After controlling for duration of illness, sex, and total gray matter, poorer verbal memory was associated with lower gray matter volume in the cingulate cortex, juxtapositional lobule, right superior temporal gyrus, and precuneus. After controlling for use of antipsychotic medication, there was an association between higher serial clustering and smaller anterior cingulate gyrus and larger intracalcarine cortex.
authors.affiliation: ODL Rehabilitation/Neuropsychological Rehabilitation, Oulu Deaconess Institute, Oulu, Finland.
authors.forename: Irina
authors.initials: I
authors.lastname: Rannikko
authors.forename: Liisa
authors.initials: L
authors.lastname: Paavola
authors.forename: Marianne
authors.initials: M
authors.lastname: Haapea
authors.forename: Sanna
authors.initials: S
authors.lastname: Huhtaniska
authors.forename: Jouko
authors.initials: J
authors.lastname: Miettunen
authors.forename: Juha
authors.initials: J
authors.lastname: Veijola
authors.forename: Graham K
authors.initials: GK
authors.lastname: Murray
authors.forename: Anna
authors.initials: A
authors.lastname: Barnes
authors.forename: Karl-Erik
authors.initials: KE
authors.lastname: Wahlberg
authors.forename: Matti
authors.initials: M
authors.lastname: Isohanni
authors.forename: Erika
authors.initials: E
authors.lastname: Jääskeläinen
mesh_terms: D000328:Adult; D001921:Brain / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008568:Memory; D059906:Neuroimaging; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000473:pathology* / Q000523:psychology*; D012559:Schizophrenia / Q000473:pathology*; D012565:Schizophrenic Psychology; D014706:Verbal Learning