title: Serum and liver tissue bio-element levels, and antioxidant enzyme activities in carbon tetrachloride-induced hepatotoxicity: protective effects of royal jelly.
abstract: The liver is a vital organ, and its function is generally impaired by chemicals. Some natural compounds have a protective role against liver diseases such as royal jelly (RJ). To our knowledge, there are no data available on the effect of RJ therapy on the levels of bio-element metabolisms and antioxidant enzyme activities in the carbon tetrachloride (CCl(4))-induced liver damage. Therefore, in the present study, we have investigated the role of RJ therapy in the trace and major elements and antioxidant enzymes in CCl(4)-induced hepatotoxicity in rats. Antioxidant enzyme activities decreased in the CCl(4)-treated group more than they did in the sham and RJ-administered groups. Many bio-element levels were also reduced in only the CCl(4)-treated group. This showed that the depletion of trace elements was related to erythrocyte antioxidant enzyme activities. RJ administration clearly increased the trace and major element levels and antioxidant enzyme activities in RJ groups. RJ may be used as functional foods because of their naturally high antioxidant potential and rich element content.
authors.affiliation: Biochemistry Division, Department of Bioengineering, Faculty of Chemical and Metallurgical Engineering, Yıldiz Technical University, Istanbul, Turkey. mcemek@yahoo.com
authors.forename: Mustafa
authors.initials: M
authors.lastname: Cemek
authors.forename: Fatma
authors.initials: F
authors.lastname: Yılmaz
authors.forename: Mehmet Emin
authors.initials: ME
authors.lastname: Büyükokuroğlu
authors.forename: Ahmet
authors.initials: A
authors.lastname: Büyükben
authors.forename: Fatih
authors.initials: F
authors.lastname: Aymelek
authors.forename: Ahmet
authors.initials: A
authors.lastname: Ayaz
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001774:Blood Chemical Analysis; D002251:Carbon Tetrachloride / Q000009:adverse effects; D004798:Enzymes / Q000097:blood*; D005227:Fatty Acids / Q000008:administration & dosage*; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008107:Liver Diseases / Q000188:drug therapy* / Q000201:enzymology; D008297:Male; D020011:Protective Agents / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley; D000099219:Royal Jelly
chemical_list: D000975:Antioxidants; D002251:Carbon Tetrachloride; D004798:Enzymes; D005227:Fatty Acids; D020011:Protective Agents; D000099219:Royal Jelly