title: Fascin and cortactin expression is correlated with a poor prognosis in hepatocellular carcinoma.
abstract: OBJECTIVE
  The aim of this study was to investigate the relationship between fascin and cortactin protein expression and clinicopathological parameters and survival time in patients with hepatocellular carcinoma (HCC).
  
  
  METHODS
  A total of 77 specimens of HCC and seven specimens of normal liver tissues were collected. The expressions of fascin and cortactin were examined by immunohistochemical staining. The patients from whom the HCCs were taken were also followed up. In these 74 patients, Kaplan-Meier was used to assess survival outcomes.
  
  
  RESULTS
  The data revealed that fascin and cortactin expressions were upregulated in the HCC samples. The positive expression of fascin significantly correlated with histological differentiation and metastasis. The positive expression of cortactin significantly correlated with histological differentiation, metastasis, and T stage (International Union Against Cancer). Survival time of the patients with positive fascin expression and positive cortactin expression was significantly decreased, and the median survival duration was short.
  
  
  CONCLUSIONS
  Fascin and cortactin might be important indicators of the malignancy and metastasis of liver cancer, and may have predictive value in the prognosis of HCC.
authors.affiliation: Institute of Digestive Endoscopy and Medical Center for Digestive Diseases, Second Affiliated Hospital of Nanjing Medical University, Nanjing, China.
authors.forename: Xiaodan
authors.initials: X
authors.lastname: Huang
authors.forename: Jie
authors.initials: J
authors.lastname: Ji
authors.forename: Huiting
authors.initials: H
authors.lastname: Xue
authors.forename: Faming
authors.initials: F
authors.lastname: Zhang
authors.forename: Xiang
authors.initials: X
authors.lastname: Han
authors.forename: Yong
authors.initials: Y
authors.lastname: Cai
authors.forename: Jianhuai
authors.initials: J
authors.lastname: Zhang
authors.forename: Guozhong
authors.initials: G
authors.lastname: Ji
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000378:metabolism*; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis* / Q000473:pathology / Q000556:secondary; D002352:Carrier Proteins / Q000378:metabolism*; D002454:Cell Differentiation / Q000502:physiology; D051356:Cortactin / Q000378:metabolism*; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D053208:Kaplan-Meier Estimate; D008099:Liver / Q000378:metabolism; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008840:Microfilament Proteins / Q000378:metabolism*; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000378:metabolism; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; D002352:Carrier Proteins; D051356:Cortactin; D008840:Microfilament Proteins; D009363:Neoplasm Proteins; C020324:fascin