title: Antinociceptive and anti-inflammatory activity of the ethanolic extract of Cymbidium aloifolium (L.).
abstract: The ethanol leaf extract of Cymbidium aloifolium (L.) was evaluated for its analgesic and antiinflammatory activities. The extract, at the dose of 200 and 400 mg kg(-1) body weight, exerted the analgesic activity by observing the number of abdominal contractions and anti-inflammatory activity against Carrageenin induced paw edema in mice by measuring the paw volume. The ethanolic extract of Cymbidium aloifolium (L.) showed statistically significant (p < 0.05) reduction of percentage of writhing of 33.57 and 61.31% at 200 and 400 mg kg(-1) oral dose, respectively, when compared to negative control. The Ethanolic plant extract also showed significant (p < 0.05) dose dependent reduction of mean increase of formation of paw edema. The results of the experiment and its statistical analysis showed that the ethanolic plant extract had shown significant (p < 0.05) dose dependent analgesic and anti-inflammatory activities when compared to the control.
authors.affiliation: Department of Pharmacy, East West University, Dhaka, Bangladesh.
authors.forename: Md Amran
authors.initials: MA
authors.lastname: Howlader
authors.forename: Mahmudul
authors.initials: M
authors.lastname: Alam
authors.forename: Kh Tanvir
authors.initials: KhT
authors.lastname: Ahmed
authors.forename: Farjana
authors.initials: F
authors.lastname: Khatun
authors.forename: Apurba Sarker
authors.initials: AS
authors.lastname: Apu
mesh_terms: D019342:Acetic Acid / Q000009:adverse effects; D000700:Analgesics / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry* / Q000494:pharmacology*; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D000431:Ethanol / Q000737:chemistry*; D005260:Female; D008297:Male; D051379:Mice; D010147:Pain Measurement / Q000187:drug effects / Q000379:methods; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D000431:Ethanol; D002351:Carrageenan; D019342:Acetic Acid