title: Recruitment methods for United States Alzheimer disease prevention trials.
abstract: There are no substantially effective treatments or preventatives for Alzheimer disease. The few prevention trials that were undertaken did not shown efficacy for the drugs tested; but, nevertheless, advanced prevention trials methods. We review past recruitment methods and discuss areas for improvement. Improvements in recruitment methods can enhance the likelihood for accurately demonstrating the efficacy of an effective drug. Effective therapeutics to prevent AD await discovery and proof.
authors.affiliation: University of Southern California Keck School of Medicine, Los Angeles, CA 90033, USA. lschneid@usc.edu
authors.forename: L S
authors.initials: LS
authors.lastname: Schneider
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control*; D015415:Biomarkers / Q000032:analysis; D002986:Clinical Trials as Topic / Q000379:methods*; D006801:Humans; D018579:Patient Selection; D012107:Research Design; D016896:Treatment Outcome; D014481:United States
chemical_list: D015415:Biomarkers