title: [The value of diffusion-weighted MR imaging combined with transrectal ultrasound for transrectal prostate biopsy].
abstract: OBJECTIVE
  To retrospectively analyze the clinical value of diffusion-weighted MR imaging in the detection of prostate cancer in suspected patients.
  
  
  METHODS
  Between January 2009 and December 2010, the 551 patients suspected as prostate cancer underwent prostate biopsy. Patients in group A were accepted to a transrectal ultrasound (TRUS) guided transrectal prostate biopsy (n = 410), while patients in group B were accepted to a diffusion weighted imaging (DWI) and TRUS jointly guided transrectal prostate biopsy (n = 141). The two groups were divided into 4 subgroups by prostate specific antigen (PSA) < 10 µg/L, 10 µg/L ≤ PSA < 20 µg/L, 20 µg/L ≤ PSA < 50 µg/L and PSA ≥ 50 µg/L. Then, the diagnostic rates of prostate biopsy guided by combination of DWI and TRUS with only TRUS were compared.
  
  
  RESULTS
  The diagnostic rate of patients with PSA < 10 µg/L, 10 µg/L ≤ PSA < 20 µg/L, 20 µg/L ≤ PSA < 50 µg/L and PSA ≥ 50 µg/L were 12.1%, 31.1%, 48.0%, 91.2% in group A, and 23.7%, 35.5%, 66.7%, 96.3% in group B, respectively. In the patients with PSA less than 10 µg/L, there were significant differences in diagnostic rate between the two biopsy techniques (χ(2) = 4.405, P < 0.05).
  
  
  CONCLUSIONS
  The combination of DWI and TRUS showed the potential to guide biopsy to cancer foci in patients suspected as prostate cancer. For patients with PSA < 10 µg/L, a DWI and TRUS jointly guided transrectal prostate biopsy was recommended.
authors.affiliation: Department of Urology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
authors.forename: Jin-you
authors.initials: JY
authors.lastname: Wang
authors.forename: Yi-jun
authors.initials: YJ
authors.lastname: Shen
authors.forename: Xiao-hang
authors.initials: XH
authors.lastname: Liu
authors.forename: Hai-liang
authors.initials: HL
authors.lastname: Zhang
authors.forename: Yao
authors.initials: Y
authors.lastname: Zhu
authors.forename: Ding-wei
authors.initials: DW
authors.lastname: Ye
authors.forename: Xu-dong
authors.initials: XD
authors.lastname: Yao
authors.forename: Shi-lin
authors.initials: SL
authors.lastname: Zhang
authors.forename: Bo
authors.initials: B
authors.lastname: Dai
authors.forename: Liang-ping
authors.initials: LP
authors.lastname: Zhou
mesh_terms: D001707:Biopsy, Needle / Q000379:methods*; D019160:Endosonography; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011467:Prostate / Q000000981:diagnostic imaging / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000473:pathology; D012189:Retrospective Studies