title: Anti-gastric adenocarcinoma activity of 2-Methoxy-1,4-naphthoquinone, an anti-Helicobacter pylori compound from Impatiens balsamina L.
abstract: 2-Methoxy-1,4-naphthoquinone (MeONQ) from Impatiens balsamina L. exhibited strong anti-H. pylori activity in our previous study. In this study, we investigated the cytotoxicity of MeONQ against gastric adenocarcinoma (MKN45 cell line) and propose the relevant mechanisms. MeONQ resulted in serious necrosis via superoxide anion catastrophe when the treatment doses were higher than 50μM, whereas apoptosis occurred at low treatment doses (25-50μM) through the caspase-dependent apoptosis pathway. Necrosis is the dominant mode of cell death. MeONQ exhibited high ability to induce gastric adenocarcinoma necrosis, showing good potential as a candidate agent for H. pylori infection related disease therapy.
authors.affiliation: Department of Food Science and Biotechnology, National Chung Hsing University, 250 Kuo-Kuang Rd., Taichung 402, Taiwan, ROC. ycwang@nchu.edu.tw
authors.forename: Yuan-Chuen
authors.initials: YC
authors.lastname: Wang
authors.forename: Yi-Han
authors.initials: YH
authors.lastname: Lin
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy*; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D016480:Helicobacter pylori / Q000187:drug effects*; D006801:Humans; D029069:Impatiens / Q000737:chemistry*; D015394:Molecular Structure; D009285:Naphthoquinones / Q000737:chemistry / Q000494:pharmacology*; D017382:Reactive Oxygen Species
chemical_list: D000900:Anti-Bacterial Agents; D009285:Naphthoquinones; D017382:Reactive Oxygen Species; C096118:2-methoxy-1,4-naphthoquinone