title: Isoprenylated flavonoid and adipogenesis-promoting constituents of Dodonaea viscosa.
abstract: Ten new isoprenylated flavonol derivatives, dodoviscins A-J (1-10), and seven known compounds (11-17) were isolated from the aerial parts of Dodonaea viscosa. Compounds 1, 2, 4, 5, 7-9, 5,7,4'-trihydroxy-3',5'-bis(3-methyl-2-buten-1-yl)-3-methoxyflavone (11), 5,7,4'-trihydroxy-3',5'-bis(3-methyl-2-buten-1-yl)-3,6-dimethoxyflavone (12), 5,7,4'-trihydroxy-3'-(4-hydroxy-3-methylbutyl)-5'-(3-methyl-2-buten-1-yl)-3,6-dimethyoxyflavone (13), sakuranetin (14), and blumeatin (15) promoted adipocyte differentiation as characterized by increased triglyceride levels in 3T3L1 cells. Compounds 1, 13, and 15 also enhanced the accumulation of lipid droplets and induced upregulation of the expression of the adipocyte-specific genes aP2 and GLUT4.
authors.affiliation: Department of Pharmacognosy, School of Pharmacy, Fudan University, 826 Zhang Heng Road, Shanghai 201203, People's Republic of China.
authors.forename: Lai-Bin
authors.initials: LB
authors.lastname: Zhang
authors.forename: Jun
authors.initials: J
authors.lastname: Ji
authors.forename: Chun
authors.initials: C
authors.lastname: Lei
authors.forename: He-Yao
authors.initials: HY
authors.lastname: Wang
authors.forename: Qin-Shi
authors.initials: QS
authors.lastname: Zhao
authors.forename: Ai-Jun
authors.initials: AJ
authors.lastname: Hou
mesh_terms: D041721:3T3-L1 Cells; D017667:Adipocytes / Q000187:drug effects / Q000378:metabolism*; D050156:Adipogenesis / Q000187:drug effects*; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D050556:Fatty Acid-Binding Proteins / Q000187:drug effects / Q000235:genetics; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D051275:Glucose Transporter Type 4 / Q000187:drug effects / Q000235:genetics; D051379:Mice; D015394:Molecular Structure; D054876:Prenylation; D029631:Sapindaceae / Q000737:chemistry*; D000094162:Phytoalexins
chemical_list: D004365:Drugs, Chinese Herbal; D050556:Fatty Acid-Binding Proteins; D005419:Flavonoids; D051275:Glucose Transporter Type 4; C084491:blumeatin; C099724:sakuranetin; D000094162:Phytoalexins