title: Concurrent chemoradiotherapy with paclitaxel and cisplatin for adenocarcinoma of the cervix.
abstract: BACKGROUND
  It is unclear whether cisplatin-based concurrent chemoradiotherapy (CCRT) has the same effect on adenocarcinoma as on squamous cell carcinoma.
  
  
  METHODS
  We retrospectively analyzed data for 32 patients with stage IIB-IVA cervical adenocarcinoma who were treated with radiotherapy (RT) or CCRT. Fourteen patients were treated with RT, 8 with CCRT using cisplatin alone (CCRT-P), and 10 with CCRT using cisplatin plus paclitaxel (CCRT-TP).
  
  
  RESULTS
  Complete response was achieved in 7/14 patients in the RT group, 4/8 patients in the CCRT-P group, and 9/10 patients in the CCRT-TP group. Ten out of the 14 patients in the RT, 7/8 patients in the CCRT-P, and 2/10 patients in the CCRT-TP groups experienced locoregional recurrence. The 5-year overall survival rate in the RT, CCRT-P, and CCRT-TP groups was 7.1%, 25.0%, and 74.1%, respectively (p=0.0094).
  
  
  CONCLUSIONS
  The present study demonstrated that CCRT-TP achieved much better local control for adenocarcinoma of the cervix, leading to a decrease in locoregional recurrence.
authors.affiliation: Department of Obstetrics and Gynecology, Graduate School of Medical Science, University of the Ryukyus, Okinawa, Japan.
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Nagai
authors.forename: Takafumi
authors.initials: T
authors.lastname: Toita
authors.forename: Akihiko
authors.initials: A
authors.lastname: Wakayama
authors.forename: Tomoko
authors.initials: T
authors.lastname: Nakamoto
authors.forename: Takuma
authors.initials: T
authors.lastname: Ooyama
authors.forename: Akemi
authors.initials: A
authors.lastname: Tokura
authors.forename: Morihiko
authors.initials: M
authors.lastname: Inamine
authors.forename: Wataru
authors.initials: W
authors.lastname: Kudaka
authors.forename: Sadayuki
authors.initials: S
authors.lastname: Murayama
authors.forename: Yoichi
authors.initials: Y
authors.lastname: Aoki
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000532:radiotherapy*; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage; D012189:Retrospective Studies; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*
chemical_list: D017239:Paclitaxel; D002945:Cisplatin