title: Composition of molecular cardiolipin species correlates with proliferation of lymphocytes.
abstract: The mitochondrial phospholipid cardiolipin (CL) is required for oxidative phosphorylation. Oxidation of CL results in the disruption of CL-cytochrome c binding and the induction of apoptosis. Large variations in the acyl-chain residues of CL have been reported, but evidence as to whether these variants exert distinct biological effects has been limited. We have studied the acyl-chain composition of CL in lymphocytes, and found marked differences between highly and slowly proliferating cells. In fast growing cells, we detected a decreased number of double bonds, and a higher amount of C16 acyl-chain residues in CL, compared with slower growing cells. However, fewer C18 acyl-chain residues were found in CL from fast growing cells compared with slower proliferating cells. Our results suggest a functional link between acyl-chain composition of CL and cell proliferation.
authors.affiliation: Department of Pathobiochemistry, Medical Faculty, Institute of Clinical Chemistry, Otto-von-Guericke University Magdeburg, Leipziger Str. 44, D-39120 Magdeburg, Germany.
authors.forename: Lorenz
authors.initials: L
authors.lastname: Schild
authors.forename: Uwe
authors.initials: U
authors.lastname: Lendeckel
authors.forename: Andreas
authors.initials: A
authors.lastname: Gardemann
authors.forename: Ingrid
authors.initials: I
authors.lastname: Wiswedel
authors.forename: Christian Andreas
authors.initials: CA
authors.lastname: Schmidt
authors.forename: Carmen
authors.initials: C
authors.lastname: Wolke
authors.forename: Reinhard
authors.initials: R
authors.lastname: Walther
authors.forename: Piotr
authors.initials: P
authors.lastname: Grabarczyk
authors.forename: Christoph
authors.initials: C
authors.lastname: Busemann
mesh_terms: D017209:Apoptosis; D002308:Cardiolipins / Q000737:chemistry* / Q000378:metabolism; D049109:Cell Proliferation; D006801:Humans; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000737:chemistry / Q000166:cytology* / Q000378:metabolism; D010084:Oxidation-Reduction
chemical_list: D002308:Cardiolipins