title: Parasitic worms and inflammatory disease.
abstract: OBJECTIVE
  Parasitic worms have evolved strategies to manipulate the host immune system, some of which may lead to a reduction in inflammation. Characterisation of the ways in which these organisms mediate an anti-inflammatory response and identification of parasite-derived molecules involved in immune modulation paves the way to novel therapeutic approaches for the treatment of inflammatory disease. This review highlights recent findings in this field of research in the context of a broader overview.
  
  
  RESULTS
  Some parasites and parasite derived products inhibit inflammatory responses through effects on both the innate and adaptive immune response. Considerable progress has been made in identifying parasite derived molecules, the ways in which they interact with the immune system and how they mediate immunomodulation.
  
  
  CONCLUSIONS
  There is great interest in the potential usefulness of parasite-mediated immunomodulation for the treatment and prevention of a range of inflammatory disorders. Much remains to be resolved regarding characterisation of potential helminth-derived biomodulators, timing and dose of exposure to the agents as well as characterisation of the modes of action so that synthetic analogues that mimic the effects can be generated.
authors.affiliation: Department of Pathology, University of Cambridge, Tennis Court Rd, Cambridge, UK. ac@mole.bio.cam.ac.uk
authors.forename: Anne
authors.initials: A
authors.lastname: Cooke
mesh_terms: D000818:Animals; D006373:Helminthiasis / Q000276:immunology; D006376:Helminths / Q000378:metabolism* / Q000502:physiology; D006790:Host-Parasite Interactions / Q000276:immunology; D006801:Humans; D007155:Immunologic Factors / Q000096:biosynthesis*; D007249:Inflammation / Q000469:parasitology* / Q000517:prevention & control; D037181:Lectins, C-Type / Q000378:metabolism; D051193:Toll-Like Receptors / Q000378:metabolism
chemical_list: D007155:Immunologic Factors; D037181:Lectins, C-Type; D051193:Toll-Like Receptors