title: Fungal biofilm resistance.
abstract: Fungal biofilm infections have become increasingly recognised as a significant clinical problem. One of the major reasons behind this is the impact that these have upon treatment, as antifungal therapy often fails and surgical intervention is required. This places a large financial burden on health care providers. This paper aims to illustrate the importance of fungal biofilms, particularly Candida albicans, and discusses some of the key fungal biofilm resistance mechanisms that include, extracellular matrix (ECM), efflux pump activity, persisters, cell density, overexpression of drug targets, stress responses, and the general physiology of the cell. The paper demonstrates the multifaceted nature of fungal biofilm resistance, which encompasses some of the newest data and ideas in the field.
authors.affiliation: Glasgow Dental School, School of Medicine, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G2 3JZ, UK.
authors.forename: Gordon
authors.initials: G
authors.lastname: Ramage
authors.forename: Ranjith
authors.initials: R
authors.lastname: Rajendran
authors.forename: Leighann
authors.initials: L
authors.lastname: Sherry
authors.forename: Craig
authors.initials: C
authors.lastname: Williams