title: A change of osteocalcin (OC) and tartrate resistant acid phosphatase 5b (TRACP-5b) with the menstrual cycle.
abstract: Bone metabolism markers associated with 4 menstrual cycle phases were evaluated in 14 healthy young females without menstrual disorder. Menstrual cycle phases were confirmed with basal body temperature for 3 months, luteinizing hormone kits, and sexual hormone concentrations of serum. The bone metabolism markers used were osteocalcin (OC), which was measured by immunoradiometric assay (IRMA), and tartrate resistant acid phosphatase 5b (TRACP-5b), which was measured by enzyme immunometric assay (EIA). The highest values of OC and TRACP-5b were observed in the ovulation phase, and TRACP-5b increased significantly when compared with levels in the menstrual phase (p<0.05). Furthermore, the changes in sex-hormone secretion involved in OC and TRACP-5b showed specific patterns during the menstrual cycle. In other words, TRACP-5b levels are influenced by sex hormones produced during the menstrual period and are based on the bone-formation status. Therefore, it is presumed that the TRACP-5b levels during ovulation play a central role in bone formation and bone metabolism.
authors.affiliation: Department of Physical Therapy, Aomori University of Health and Welfare, Aomori-shi, Aomori, Japan. leesu@auhw.ac.jp
authors.forename: S
authors.initials: S
authors.lastname: Lee
authors.forename: T
authors.initials: T
authors.lastname: Kumagai
authors.forename: J
authors.initials: J
authors.lastname: Hashimoto
authors.forename: A
authors.initials: A
authors.lastname: Satoh
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: K
authors.initials: K
authors.lastname: Yamai
authors.forename: S
authors.initials: S
authors.lastname: Ohta
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism*; D000293:Adolescent; D001842:Bone and Bones / Q000201:enzymology / Q000378:metabolism*; D005260:Female; D012739:Gonadal Steroid Hormones / Q000378:metabolism; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism*; D008597:Menstrual Cycle; D015675:Osteocalcin / Q000378:metabolism*; D000071681:Tartrate-Resistant Acid Phosphatase; D055815:Young Adult
chemical_list: D012739:Gonadal Steroid Hormones; D007527:Isoenzymes; D015675:Osteocalcin; C000605510:ACP5 protein, human; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase