title: Corticosteroids in the treatment of chemotherapy-induced nausea and vomiting.
abstract: Chemotherapy-induced nausea and vomiting (CINV) is one of the most feared side effects of cancer treatment, despite the advances over the past decades. Corticosteroids have been shown to be effective in the management of CINV. These agents are usually used in combination with serotonin antagonists and neurokinin-1 antagonists for highly or moderately emetogenic chemotherapy or as monotherapy for low-emetogenic chemotherapy. Consensus guidelines provide guidance regarding the scenarios in which corticosteroids are recommended. This article reviews the mechanism of action, role, and safety of corticosteroids in the management of CINV.
authors.affiliation: Department of Pharmacy, Duke University Medical Center, Durham, North Carolina 27710, USA. sally.yowell@duke.edu
authors.forename: Sally Yowell
authors.initials: SY
authors.lastname: Barbour
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000932:Antiemetics / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000009:adverse effects; D006801:Humans; D009325:Nausea / Q000139:chemically induced / Q000188:drug therapy*; D017410:Practice Guidelines as Topic; D012307:Risk Factors; D014839:Vomiting / Q000139:chemically induced / Q000188:drug therapy*
chemical_list: D000305:Adrenal Cortex Hormones; D000932:Antiemetics; D000970:Antineoplastic Agents