title: Risk factors for anastomotic leakage after colectomy.
abstract: BACKGROUND
  Anastomotic leakage is a morbid and potentially fatal complication of colorectal surgery. Determination of pre- and intraoperative risk factors may identify patients requiring increased postoperative surveillance for this major complication.
  
  
  OBJECTIVE
  The purpose of this study was to identify risk factors associated with anastomotic leakage after colectomy with primary intra-abdominal anastomosis.
  
  
  METHODS
  The prospective, statewide multicenter Michigan Surgical Quality Collaborative database was analyzed.
  
  
  METHODS
  This study was performed at academic and community medical centers in the state of Michigan.
  
  
  METHODS
  Included were all cases of open and laparoscopic colectomy with primary intra-abdominal anastomosis from 2007 through 2010.
  
  
  METHODS
  Univariate analysis followed by a multivariate logistic regression model was used to determine the influence of patient factors and operative events with respect to the incidence of postoperative anastomotic leakage.
  
  
  RESULTS
  Inclusion criteria were met by 4340 cases. Anastomotic leakage occurred in 85 (3.2%) of the 2626 (60.5%) open colectomies, and in 51 (3.0%) of the 1714 (39.5%) laparoscopic procedures, which was not significantly different (p = 0.63). Significant risk factors associated with anastomotic leakage based on the multivariate logistic regression model were fecal contamination with OR 2.51, 95% CI, 1.16 to 5.45, p = 0.02; and intraoperative blood loss of more than 100 mL and 300 mL, with OR 1.62, 95% CI, 1.10 to 2.40, p = 0.02; and OR 2.22, 95% CI, 1.32 to 3.76, p = 0.003.
  
  
  CONCLUSIONS
  The Michigan Surgical Quality Collaborative colectomy project excluded high-risk rectal resections and low pelvic anastomoses. Information about operative technique and intraoperative events is limited, and anastomotic leakage was determined through chart review.
  
  
  CONCLUSIONS
  Fecal contamination and increased blood loss during colectomy should raise suspicion for potential postoperative anastomotic leakage.
authors.affiliation: Department of Surgery, Saint Joseph Mercy Health System, Ann Arbor, Michigan, USA. leichtls@trinity-health.org
authors.forename: Stefan W
authors.initials: SW
authors.lastname: Leichtle
authors.forename: Nicolas J
authors.initials: NJ
authors.lastname: Mouawad
authors.forename: Kathleen B
authors.initials: KB
authors.lastname: Welch
authors.forename: Richard M
authors.initials: RM
authors.lastname: Lampman
authors.forename: Robert K
authors.initials: RK
authors.lastname: Cleary
mesh_terms: D057868:Anastomotic Leak / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology; D003082:Colectomy / Q000009:adverse effects* / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D010535:Laparoscopy / Q000009:adverse effects; D007813:Laparotomy / Q000009:adverse effects; D008297:Male; D008824:Michigan / Q000453:epidemiology; D008875:Middle Aged; D011446:Prospective Studies; D011785:Quality Assurance, Health Care; D018570:Risk Assessment / Q000379:methods*; D012307:Risk Factors