title: Immunohistochemical characterization of perineal melanoma in Kilis goats.
abstract: We describe the clinical, histopathological and immunohistochemical features of the malignant melanomas in the perineal regions of Kilis goats from Sanliurfa province in Turkey. We studied 13 female Kilis goats between 3 and 8 years old that were brought to Harran University Veterinary School, Department of Surgery, between 2002 and 2010. By macroscopic examination, the masses were determined to have elastic consistency, dark brown-black color, necrotic surfaces and ulceration. Microscopically, pleomorphic cells were observed under the basal layer and these advanced toward the dermis. These cells were polyhedral, round or spindle-shaped, anaplastic, and their cytoplasm contained varying amounts of dark brown-black pigments. Immunohistochemical staining was obtained with anti-melan A, vimentin and S100 antibodies.
authors.affiliation: Department of Pathology, Faculty of Veterinary Medicine, University of Harran, Sanliurfa, Turkey. zaferozyildiz@hotmail.com
authors.forename: Z
authors.initials: Z
authors.lastname: Ozyildiz
authors.forename: C
authors.initials: C
authors.lastname: Ceylan
authors.forename: R
authors.initials: R
authors.lastname: Yilmaz
authors.forename: S Y
authors.initials: SY
authors.lastname: Ozsoy
mesh_terms: D000818:Animals; D005260:Female; D006041:Goats; D007150:Immunohistochemistry; D058965:MART-1 Antigen / Q000378:metabolism; D008545:Melanoma / Q000737:chemistry / Q000378:metabolism / Q000473:pathology*; D009363:Neoplasm Proteins / Q000378:metabolism; D009418:S100 Proteins / Q000378:metabolism; D012878:Skin Neoplasms / Q000737:chemistry / Q000378:metabolism / Q000473:pathology*; D013194:Staining and Labeling / Q000379:methods; D014746:Vimentin / Q000378:metabolism
chemical_list: D058965:MART-1 Antigen; D009363:Neoplasm Proteins; D009418:S100 Proteins; D014746:Vimentin