title: AGT M235T polymorphism contributes to risk of preeclampsia: evidence from a meta-analysis.
abstract: OBJECTIVE
  Preeclampsia a hypertensive disorder of pregnancy that mainly manifests as high blood pressure and proteinuria. Angiotensinogen (AGT) plays important roles in the regulation of blood pressure. The purpose of this study was to investigate the relationship between AGT M235T polymorphism and risk of preeclampsia using a meta-analysis.
  
  
  METHODS
  In this meta-analysis, 22 studies were selected by searching PubMed, EMBASE, ISI and CNKI databases up to October 2011. Crude odds ratios with corresponding 95% confidence intervals were used to evaluate the association between the AGT M235T polymorphism and risk of preeclampsia. Subgroup analyses were conducted by ethnicity and parity.
  
  
  RESULTS
  The TT genotype of the AGT M235T polymorphism was associated with elevated risk of preeclampsia in the overall analysis. In subgroup analysis according to ethnicity, increased risks were also found in Caucasians. After stratification based on parity, the excess risk was found in multigravida.
  
  
  CONCLUSIONS
  These results showed that the TT genotype may play critical roles in the development of preeclampsia.
authors.affiliation: Department of Obstetrics and Gynaecology, West China Second University Hospital, Sichuan University, PR China.
authors.forename: Shanshan
authors.initials: S
authors.lastname: Ni
authors.forename: Yanyan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yulin
authors.initials: Y
authors.lastname: Deng
authors.forename: Yunhui
authors.initials: Y
authors.lastname: Gong
authors.forename: Juan
authors.initials: J
authors.lastname: Huang
authors.forename: Yi
authors.initials: Y
authors.lastname: Bai
authors.forename: Rong
authors.initials: R
authors.lastname: Zhou
mesh_terms: D019943:Amino Acid Substitution / Q000235:genetics*; D000808:Angiotensinogen / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics; D005260:Female; D056726:Genetic Association Studies; D018740:Genetic Heterogeneity; D020022:Genetic Predisposition to Disease; D006801:Humans; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D017594:Publication Bias; D012307:Risk Factors
chemical_list: C534931:AGT protein, human; D000808:Angiotensinogen