title: Layers of regulation in induction of mixed chimerism by anti-CD40L.
abstract: The pathways regulating immunological tolerance are complex and overlapping. Here, we comment on our findings that the PD-1, CTLA-4, LAG-3 and TGFβ inhibitory molecules are all involved in mediating peripheral CD8 T‑cell tolerance induced by anti-CD40L and allogeneic bone marrow transplantation in mice. These observations suggest the possibility of targeted manipulation of these pathways for induction of mixed hematopoietic chimerism for donor-specific transplantation tolerance.
authors.affiliation: Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
authors.forename: Carrie L
authors.initials: CL
authors.lastname: Lucas
authors.forename: Megan
authors.initials: M
authors.lastname: Sykes
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology*; D015703:Antigens, CD / Q000737:chemistry / Q000378:metabolism; D000943:Antigens, Differentiation / Q000737:chemistry / Q000378:metabolism; D016026:Bone Marrow Transplantation / Q000276:immunology; D023201:CD40 Ligand / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D060908:CTLA-4 Antigen / Q000037:antagonists & inhibitors / Q000378:metabolism; D046528:Chimerism; D051379:Mice; D061026:Programmed Cell Death 1 Receptor; D016212:Transforming Growth Factor beta / Q000037:antagonists & inhibitors / Q000378:metabolism; D023001:Transplantation Tolerance / Q000276:immunology; D014184:Transplantation, Homologous; D000093322:Lymphocyte Activation Gene 3 Protein
chemical_list: D000906:Antibodies; D015703:Antigens, CD; D000943:Antigens, Differentiation; D060908:CTLA-4 Antigen; C491383:Pdcd1 protein, mouse; D061026:Programmed Cell Death 1 Receptor; D016212:Transforming Growth Factor beta; D023201:CD40 Ligand; D000093322:Lymphocyte Activation Gene 3 Protein; C000720327:Lag3 protein, mouse