title: Asymmetric allylic alkylation of pyrroles and 4,7-dihydroindoles with alkene-phosphine ligands.
abstract: A palladium-catalyzed highly enantioselective allylic alkylation of pyrroles and 4,7-dihydroindoles has been successfully developed with the use of chiral alkene-phosphine hybrid ligands to furnish the desired products in high yields with excellent ee's. It is noteworthy that alkene-phosphine ligands are much more effective than some other types of chiral ligands in this catalytic system.
authors.affiliation: Beijing National Laboratory of Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
authors.forename: Yilin
authors.initials: Y
authors.lastname: Liu
authors.forename: Ziping
authors.initials: Z
authors.lastname: Cao
authors.forename: Haifeng
authors.initials: H
authors.lastname: Du
mesh_terms: D000475:Alkenes / Q000737:chemistry*; D000478:Alkylation; D000498:Allyl Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry*; D008024:Ligands; D015394:Molecular Structure; D010720:Phosphines / Q000737:chemistry*; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D000498:Allyl Compounds; D007211:Indoles; D008024:Ligands; D010720:Phosphines; D011758:Pyrroles; C044646:phosphine