title: Patterns of acute rhesus cytomegalovirus (RhCMV) infection predict long-term RhCMV infection.
abstract: We previously reported that long-term rhesus cytomegalovirus (RhCMV) excretion in infected macaques was related to UL/b' coding content. Acute biopsy specimens of the inoculation sites from the previous study have now been analyzed to determine whether there were acute phenotypic predictors of long-term RhCMV infection. Only in animals displaying acute endothelial tropism and neutrophilic inflammation was RhCMV excretion detected. The results imply that vaccinating against these early viral determinants would significantly impede long-term RhCMV infection.
authors.affiliation: Center for Comparative Medicine, University of California, Davis, Davis, California, USA.
authors.forename: Basel T
authors.initials: BT
authors.lastname: Assaf
authors.forename: Keith G
authors.initials: KG
authors.lastname: Mansfield
authors.forename: Susan V
authors.initials: SV
authors.lastname: Westmoreland
authors.forename: Amitinder
authors.initials: A
authors.lastname: Kaur
authors.forename: Kristie L
authors.initials: KL
authors.lastname: Oxford
authors.forename: Don J
authors.initials: DJ
authors.lastname: Diamond
authors.forename: Peter A
authors.initials: PA
authors.lastname: Barry
mesh_terms: D000818:Animals; D002908:Chronic Disease; D003587:Cytomegalovirus / Q000472:pathogenicity*; D003586:Cytomegalovirus Infections / Q000473:pathology / Q000662:veterinary*; D042783:Endothelial Cells / Q000821:virology; D008251:Macaca; D009504:Neutrophils / Q000276:immunology; D018419:Primate Diseases / Q000473:pathology* / Q000821:virology*