title: Stereocontrolled access to optically-enriched oxabispidines.
abstract: A range of chiral, optically-enriched bicyclic oxabispidines were prepared from (S)-(-)-2,3-epoxypropylphthalimide using an efficient sequence featuring a stereocontrolled intramolecular Mannich reaction as the key transformation.
authors.affiliation: Pharmaceutical Development, AstraZeneca R&D Charnwood, Bakewell Road, Loughborough LE11 5RH, UK.
authors.forename: Heloise
authors.initials: H
authors.lastname: Brice
authors.forename: Duncan M
authors.initials: DM
authors.lastname: Gill
authors.forename: Laura
authors.initials: L
authors.lastname: Goldie
authors.forename: Philip S
authors.initials: PS
authors.lastname: Keegan
authors.forename: William J
authors.initials: WJ
authors.lastname: Kerr
authors.forename: Per H
authors.initials: PH
authors.lastname: Svensson
mesh_terms: D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis / Q000737:chemistry*; D018360:Crystallography, X-Ray; D003500:Cyclization; D008968:Molecular Conformation; D010797:Phthalimides / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; D010797:Phthalimides; C495809:bispidine; C037431:phthalimide