title: Targeting the DNA-topoisomerase complex in a double-strike approach with a topoisomerase inhibiting moiety and covalent DNA binder.
abstract: Ru(II)(arene)-flavonoids with high in vitro antitumour activity were synthesised. These compounds are capable of inhibiting human topoisomerase IIα and binding covalently to DNA.
authors.affiliation: University of Vienna, Institute of Inorganic Chemistry, Währinger Str. 42, 1090 Vienna, Austria.
authors.forename: Andrea
authors.initials: A
authors.lastname: Kurzwernhart
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Kandioller
authors.forename: Caroline
authors.initials: C
authors.lastname: Bartel
authors.forename: Simone
authors.initials: S
authors.lastname: Bächler
authors.forename: Robert
authors.initials: R
authors.lastname: Trondl
authors.forename: Gerhard
authors.initials: G
authors.lastname: Mühlgassner
authors.forename: Michael A
authors.initials: MA
authors.lastname: Jakupec
authors.forename: Vladimir B
authors.initials: VB
authors.lastname: Arion
authors.forename: Doris
authors.initials: D
authors.lastname: Marko
authors.forename: Bernhard K
authors.initials: BK
authors.lastname: Keppler
authors.forename: Christian G
authors.initials: CG
authors.lastname: Hartinger
mesh_terms: D000951:Antigens, Neoplasm / Q000378:metabolism*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D056831:Coordination Complexes / Q000737:chemistry / Q000494:pharmacology; D004247:DNA / Q000378:metabolism*; D004250:DNA Topoisomerases, Type II / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism*; D005419:Flavonoids / Q000737:chemistry; D006801:Humans; D008968:Molecular Conformation; D011485:Protein Binding; D012428:Ruthenium / Q000737:chemistry
chemical_list: D000951:Antigens, Neoplasm; D000970:Antineoplastic Agents; D056831:Coordination Complexes; D004268:DNA-Binding Proteins; D005419:Flavonoids; D012428:Ruthenium; D004247:DNA; D004250:DNA Topoisomerases, Type II