title: Survival patterns in white-tailed and mule deer after oral inoculation with a standardized, conspecific prion dose.
abstract: We orally inoculated white-tailed deer (Odocoileus virginianus) and mule deer (Odocoileus hemionus) with a standardized, conspecific prion dose and collected biologic samples throughout the disease course. Mule deer (PRNP genotype 225SS) and PRNP genotype 96GG white-tailed deer succumbed along similar trajectories, but 96GS- and 96SS-genotype individuals tended to survive longer.
authors.forename: Michael W
authors.initials: MW
authors.lastname: Miller
authors.forename: Lisa L
authors.initials: LL
authors.lastname: Wolfe
authors.forename: Tracey M
authors.initials: TM
authors.lastname: Sirochman
authors.forename: Michael A
authors.initials: MA
authors.lastname: Sirochman
authors.forename: Jean E
authors.initials: JE
authors.lastname: Jewell
authors.forename: Elizabeth S
authors.initials: ES
authors.lastname: Williams
mesh_terms: D000818:Animals; D003670:Deer / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D005838:Genotype; D011328:Prions / Q000008:administration & dosage* / Q000472:pathogenicity*; D016019:Survival Analysis; D034081:Wasting Disease, Chronic / Q000401:mortality*
chemical_list: D011328:Prions