title: OXA-163-producing Klebsiella pneumoniae in Cairo, Egypt, in 2009 and 2010.
abstract: Two genetically unrelated OXA-163-carrying Klebsiella pneumoniae strains were identified from two infection cases in June 2009 and May 2010 in Cairo, Egypt. OXA-163-producing Enterobacteriaceae had been previously reported in Argentina only. Both patients had no history of travel abroad. The emergence of this newly recognized OXA-48-related β-lactamase able to hydrolyze cephalosporins and carbapenems is especially worrying in a geographic area where OXA-48 is endemic and effective surveillance for antibiotic resistance is largely unaffordable.
authors.affiliation: Department of Microbiology and Immunology, Faculty of Pharmacy, Helwan University, Cairo, Egypt.
authors.forename: Mohammed O
authors.initials: MO
authors.lastname: Abdelaziz
authors.forename: Celestino
authors.initials: C
authors.lastname: Bonura
authors.forename: Aurora
authors.initials: A
authors.lastname: Aleo
authors.forename: Ramadan A
authors.initials: RA
authors.lastname: El-Domany
authors.forename: Teresa
authors.initials: T
authors.lastname: Fasciana
authors.forename: Caterina
authors.initials: C
authors.lastname: Mammina
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000378:metabolism; D015780:Carbapenems / Q000378:metabolism; D002511:Cephalosporins / Q000378:metabolism; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D004534:Egypt / Q000453:epidemiology; D005260:Female; D006801:Humans; D006868:Hydrolysis; D007710:Klebsiella Infections / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000187:drug effects / Q000201:enzymology* / Q000302:isolation & purification*; D008297:Male; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000235:genetics*
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; D002511:Cephalosporins; D004269:DNA, Bacterial; D001618:beta-Lactamases