title: Turning Tregs into class I suppressors.
abstract: In this issue of Blood, Plesa et al demonstrate that human Foxp3(+) regulatory T cells can be redirected using MHC class I–restricted T-cell receptors (TCRs), showing a surprising lack of correlation of TCR affinity and their suppressive potency.
authors.affiliation: St Jude Children's Research Hospital.
authors.forename: Terrence L
authors.initials: TL
authors.lastname: Geiger
mesh_terms: D006801:Humans; D037182:T-Cell Antigen Receptor Specificity / Q000502:physiology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000502:physiology*