title: Prevalence and risk factors of HSV-2 infection and HSV-2/HIV coinfection in men who have sex with men in China: a multisite cross-sectional study.
abstract: OBJECTIVE
  To determine the prevalence and risk factors of herpes simplex virus type 2 (HSV-2) infection and its coinfection with human immunodeficiency virus (HIV) in men who have sex with men (MSM) in China.
  
  
  METHODS
  A convenience sample of 1462 MSM were recruited from different settings (an STD clinic, a health center, and MSM venues) in 3 cities in China. Blood specimens were collected for testing for antibodies to HSV-2 and HIV to determinate the seroprevalence of HSV-2 infection and HSV-2/HIV coinfection. Information on sociodemographic and behavioral characteristics was collected to determine the risk factors associated with the infections.
  
  
  RESULTS
  The prevalence of HSV-2 infection in 1462 MSM was 16.0% (95% confidence interval [CI], 14.2%-18.0%), the prevalence of HIV infection in this population was 9.5% (95% CI, 8.1%-11.1%), and the rate of coinfection of HSV-2 and HIV was 3.2% (95% CI, 2.4%-4.3%). Multivariate logistic regression analysis showed that risk factors for HSV-2 infection included age older than 30 years, education level lower than senior high school, involvement in commercial sex work, and HIV-positive status. Education level lower than junior high school and history of sexual abuse were associated with HSV-2/HIV coinfection.
  
  
  CONCLUSIONS
  The high prevalence of HSV-2 infection and HSV-2/HIV coinfection among MSM in China suggests that an increased focus on HSV control is warranted within China's prevention and intervention programs targeted toward MSM.
authors.affiliation: National Center for STD Control, and Chinese Academy of Medical Sciences & Peking Union Medical College Institute of Dermatology, Nanjing, China.
authors.forename: Yue-Ping
authors.initials: YP
authors.lastname: Yin
authors.forename: Shao-Chun
authors.initials: SC
authors.lastname: Chen
authors.forename: Hong-Chun
authors.initials: HC
authors.lastname: Wang
authors.forename: Wan-Hui
authors.initials: WH
authors.lastname: Wei
authors.forename: Qian-Qiu
authors.initials: QQ
authors.lastname: Wang
authors.forename: Guo-Jun
authors.initials: GJ
authors.lastname: Liang
authors.forename: Ning
authors.initials: N
authors.lastname: Jiang
authors.forename: Yan
authors.initials: Y
authors.lastname: Han
authors.forename: Xiang-Sheng
authors.initials: XS
authors.lastname: Chen
authors.forename: Baoxi
authors.initials: B
authors.lastname: Wang
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000453:epidemiology*; D000293:Adolescent; D000328:Adult; D015153:Blotting, Western; D002681:China / Q000453:epidemiology; D060085:Coinfection; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D006558:Herpes Genitalis / Q000453:epidemiology*; D018451:Homosexuality, Male / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D015995:Prevalence; D012307:Risk Factors; D012725:Sexual Behavior / Q000706:statistics & numerical data*; D011795:Surveys and Questionnaires; D055815:Young Adult