title: A comparative study of HRCT image metrics and PFT values for characterization of ILD and COPD.
abstract: OBJECTIVE
  The aim of this study was to compare the performance of various image-based metrics computed from thoracic high-resolution computed tomography (HRCT) with data from pulmonary function testing (PFT) in characterizing interstitial lung disease (ILD) and chronic obstructive pulmonary disease (COPD).
  
  
  METHODS
  Fourteen patients with ILD and 11 with COPD had undergone both PFT and HRCT within 3 days. For each patient, 93 image-based metrics were computed, and their relationships with the 21 clinically used PFT parameters were analyzed using a minimal-redundancy-maximal-relevance statistical framework. The first 20 features were selected among the total of 114 mixed image metrics and PFT values in the characterization of ILD and COPD.
  
  
  RESULTS
  Among the best-performing 20 features, 14 were image metrics, derived from attenuation histograms and texture descriptions. The highest relevance value computed from PFT parameters was 0.47, and the highest from image metrics was 0.52, given the theoretical bound as [0, 0.69]. The ILD or COPD classifier using the first four features achieved a 1.92% error rate.
  
  
  CONCLUSIONS
  Some image metrics are not only as good discriminators as PFT for the characterization of ILD and COPD but are also not redundant when PFT values are provided. Image metrics of attenuation histogram statistics and texture descriptions may be valuable for further investigation in computer-assisted diagnosis.
authors.affiliation: Penn Image Computing and Science Laboratory, University of Pennsylvania School of Medicine, 3600 Market Street, Suite 370, Philadelphia, PA 19104, USA. songgang@seas.upenn.edu
authors.forename: Gang
authors.initials: G
authors.lastname: Song
authors.forename: Eduardo
authors.initials: E
authors.lastname: Mortani Barbosa
authors.forename: Nicholas
authors.initials: N
authors.lastname: Tustison
authors.forename: Warren B
authors.initials: WB
authors.lastname: Gefter
authors.forename: Maryl
authors.initials: M
authors.lastname: Kreider
authors.forename: James C
authors.initials: JC
authors.lastname: Gee
authors.forename: Drew A
authors.initials: DA
authors.lastname: Torigian
mesh_terms: D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D017563:Lung Diseases, Interstitial / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D029424:Pulmonary Disease, Chronic Obstructive / Q000000981:diagnostic imaging* / Q000503:physiopathology; D012129:Respiratory Function Tests; D014057:Tomography, X-Ray Computed