title: 23-year-old man with a superficial cortical brain tumor.
abstract: A 23-year-old male presented with a tonic-clonic generalized seizure. Neuroradiological examination revealed a superficial cystic mass with a mural nodule in the right fronto-parietal lobe. Histological and immunohistochemical examination were consistent with a pigmented (melanin producing) desmoplastic ganglioglioma.These tumors have been first described in childhood, one of them displaying melanin deposits. Only twenty cases of non-infantile desmoplastic gangliogliomas have been reported in the literature, none of them pigmented. According to the clinical and histomorphology (including the desmoplastic component) features, the differential diagnosis should include the ganglioglioma, the xanthoastrocytoma pleomorphic (both tumors also with pigmented forms) and the superficial desmoplastic infantile astrocytoma.
authors.forename: Sónia
authors.initials: S
authors.lastname: Costa
authors.forename: Joana
authors.initials: J
authors.lastname: Marques
authors.forename: Pedro
authors.initials: P
authors.lastname: Pereira
authors.forename: Carla
authors.initials: C
authors.lastname: Firmo
authors.forename: José
authors.initials: J
authors.lastname: Pimentel
mesh_terms: D001932:Brain Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D003399:Craniotomy; D005625:Frontal Lobe / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D018303:Ganglioglioma / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D008543:Melanins / Q000378:metabolism; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D008543:Melanins