title: Metabolic and genetic factors modulating subject specific LDL-C responses to plant sterol therapy.
abstract: Reducing intestinal cholesterol absorption with plant sterol consumption is a well-characterized strategy to lower LDL-C and potentially reduce cardiovascular disease risk. However, over 50 years of clinical research demonstrate that there is significant heterogeneity in the individual LDL-C lowering response to plant sterol therapy. A clear understanding of why plant sterols work effectively in some individuals but not in others will ensure optimal integration of plant sterols in future personalized nutritional lipid-lowering strategies. This review will examine the current knowledge base surrounding the metabolic and genetic determinants of LDL-C lowering in response to plant sterol consumption.
authors.affiliation: Department of Exercise and Nutrition Sciences, University at Buffalo, NY 14214, USA. rideout@buffalo.edu
authors.forename: Todd C
authors.initials: TC
authors.lastname: Rideout
authors.forename: Scott V
authors.initials: SV
authors.lastname: Harding
authors.forename: Dylan S
authors.initials: DS
authors.lastname: Mackay
mesh_terms: D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D008078:Cholesterol, LDL / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism*; D007206:Individuality; D010840:Phytosterols / Q000494:pharmacology*
chemical_list: D000924:Anticholesteremic Agents; D008078:Cholesterol, LDL; D010840:Phytosterols