title: Nocardia harenae, an uncommon causative organism of mycetoma: report on two patients.
abstract: Mycetoma is the most frequently diagnosed deep mycosis in Mexico and is caused, in 86% of cases, by Nocardia brasiliensis. Worldwide, Nocardia harenae has not been previously reported as a causative agent of human mycetoma. Herein we report, to our knowledge, the first two human cases of mycetoma due to N. harenae in a clinical setting. The strains were identified by phenotypic and molecular techniques. Both cases were characterized by long-lasting mycetoma that had previously been failed to be cured and had shown resistance to therapy. However, in our hospital, a multidrug therapy proved to be effective in these cases.
authors.affiliation: Servicio de Dermatología, Hospital General 'Dr Manuel Gea González', Tlalpan 14080, Mexico.
authors.forename: Nicole S
authors.initials: NS
authors.lastname: Kresch-Tronik
authors.affiliation: Departamento de Biología Molecular e Histocompatibilidad, Hospital General 'Dr Manuel Gea González', Tlalpan 14080, Mexico.
authors.forename: Erika M
authors.initials: EM
authors.lastname: Carrillo-Casas
authors.affiliation: Departamento de Micología, Hospital General 'Dr Manuel Gea González', Tlalpan 14080, Mexico.
authors.forename: Roberto
authors.initials: R
authors.lastname: Arenas
authors.affiliation: Departamento de Micología, Centro Dermatológico 'Dr Fernando Latapí'. Mérida, Yucatán, Mexico.
authors.forename: Carlos
authors.initials: C
authors.lastname: Atoche
authors.affiliation: Departamento de Ecología de Agentes Patógenos, Hospital General 'Dr Manuel Gea González', Tlalpan 14080, Mexico.
authors.forename: Luis A
authors.initials: LA
authors.lastname: Ochoa-Carrera
authors.affiliation: Departamento de Infectología, Hospital Infantil de México 'Federico Gómez', Mexico City, Mexico.
authors.forename: Juan
authors.initials: J
authors.lastname: Xicohtencatl-Cortes
authors.affiliation: Departamento de Salud Pública, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico.
authors.forename: Ángel H
authors.initials: ÁH
authors.lastname: Manjarrez-Hernández
authors.affiliation: Departamento de Ecología de Agentes Patógenos, Hospital General 'Dr Manuel Gea González', Tlalpan 14080, Mexico.
authors.forename: Rigoberto
authors.initials: R
authors.lastname: Hernández-Castro
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D008969:Molecular Sequence Data; D008271:Mycetoma / Q000175:diagnosis* / Q000382:microbiology* / Q000473:pathology; D009615:Nocardia / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D009617:Nocardia Infections / Q000175:diagnosis* / Q000382:microbiology* / Q000473:pathology; D017422:Sequence Analysis, DNA; D012867:Skin / Q000473:pathology; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial