title: [Radiation induced carcinogenesis].
abstract: Intense research after Hiroshima and Nagasaki atomic bomb (A-bomb) tragedy and Chernobyl nuclear plant accident revealed that ionizing radiation (IR) more than 100 mSv induces cancers that are indistinguishable from sporadic tumors. It remains controversial whether low dose IR (less than 100 mSv) is oncogenic or not. Among IR-induced malignancies, leukemia (A-bomb) and thyroid cancers (Chernobyl), in which chimeric(fusion) oncogenes formed by chromosome translocations play a critical role, develop with relatively short latency. All other cancers develop after long latency. Age-related epigenetic changes, as well as additional genetic alterations, would contribute to IR-induced carcinogenesis.
authors.affiliation: Department of Molecular Oncology & Leukemia Program Project, Research Institute for Radiation Biology & Medicine, Hiroshima University.
authors.forename: Toshiya
authors.initials: T
authors.lastname: Inaba
mesh_terms: D006801:Humans; D009381:Neoplasms, Radiation-Induced / Q000235:genetics; D018788:Radioactive Hazard Release