title: Conjugated polyelectrolyte-antibody hybrid materials for highly fluorescent live cell-imaging.
abstract: Conjugated polyelectrolyte-antibody hybrid materials promise to enhance the utility of conjugated polymers in bioimaging field. Polymer-antibody conjugates that are biologically safe and highly sensitive and selective to cells are designed to image human T or B lymphocytes. In the clear state, the observed efficiency of luminescence is superior to that of commercially available FITC-antibody probe.
authors.affiliation: Department of Materials Science and Engineering, University of Michigan, 2300 Hayward St., Ann Arbor, MI 48109, USA.
authors.forename: Kangwon
authors.initials: K
authors.lastname: Lee
authors.forename: Jiseok
authors.initials: J
authors.lastname: Lee
authors.forename: Eun Jeong
authors.initials: EJ
authors.lastname: Jeong
authors.forename: Adam
authors.initials: A
authors.lastname: Kronk
authors.forename: Kojo S J
authors.initials: KS
authors.lastname: Elenitoba-Johnson
authors.forename: Megan S
authors.initials: MS
authors.lastname: Lim
authors.forename: Jinsang
authors.initials: J
authors.lastname: Kim
mesh_terms: D000906:Antibodies / Q000737:chemistry* / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004573:Electrolytes / Q000737:chemistry*; D016650:Fluorescein-5-isothiocyanate / Q000737:chemistry*; D006801:Humans; D019169:Jurkat Cells; D018613:Microscopy, Confocal; D011108:Polymers / Q000737:chemistry / Q000633:toxicity; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology
chemical_list: D000906:Antibodies; D004573:Electrolytes; D011108:Polymers; C473966:poly(phenylene ethynylene); D016650:Fluorescein-5-isothiocyanate