title: Phalangeal quantitative ultrasound measurements in chronic hemodialysis patients: a 4-year follow-up.
abstract: In the course of chronic kidney disease, bone metabolism disturbances occur and become aggravated simultaneously with the progression of renal disorder, worsening patients' quality of life. We conducted a 4-year follow-up to assess phalangeal quantitative ultrasound (QUS) measurements in 32 patients undergoing chronic hemodialysis (17 males and 15 females) whose mean ages were 56.3 ± 15.2 years. The QUSs of hand phalanges were performed using DBM 1200 (IGEA, Carpi, Italy) and are expressed as amplitude-dependent speed of sound (Ad-SoS), Z-scores, and T-scores. In comparison with the age-, sex-, and body mass index-adjusted control group, QUS parameters were significantly decreased in all patients undergoing dialysis. During the 4-year follow-up, Ad-SoS and T-scores in all study groups sloped significantly with time. The significant negative relationships between follow-up Ad-SoS results and both baseline and follow-up parathormone values were demonstrated. Our results confirm a high prevalence of bone disturbances in patients undergoing chronic hemodialysis, and they do not improve during renal replacement therapy. The parathormone level seems to be an important agent in influencing bone status, but further studies are needed to understand the other risk factors in kidney-related bone disease.
authors.affiliation: Department of Internal Medicine, Diabetology and Nephrology, Zabrze, Medical University of Silesia, Katowice, Poland. jzywiec@sum.edu.pl
authors.forename: Joanna
authors.initials: J
authors.lastname: Zywiec
authors.forename: Wojciech
authors.initials: W
authors.lastname: Pluskiewicz
authors.forename: Piotr
authors.initials: P
authors.lastname: Adamczyk
authors.forename: Alina
authors.initials: A
authors.lastname: Skubala
authors.forename: Janusz
authors.initials: J
authors.lastname: Gumprecht
mesh_terms: D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000000981:diagnostic imaging*; D018450:Disease Progression; D005260:Female; D050278:Finger Phalanges / Q000000981:diagnostic imaging*; D005500:Follow-Up Studies; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D012044:Regression Analysis; D006435:Renal Dialysis; D014463:Ultrasonography