title: [Macular ischemia following intravitreal bevacizumab therapy for diabetic macular edema].
abstract: OBJECTIVE
  To examine the effects of macular ischemia after intravitreal bevacizumab (IVB) in patients with diabetic macular edema(DME).
  
  
  METHODS
  Thirty-three eyes of 33 patients with DME were treated with IVB. Fluorescein angiography (FA) was conducted before and 3 months after IVB, the pretreatment sizes of the foveal avascular zone (FAZ) calculated by FA were compared to the values at 3 months after IVB. This study was approved by the Chiba University Hospital Clinical Research Ethics Committee.
  
  
  RESULTS
  After IVB, the size of the FAZ enlarged significantly (p = 0.03). Among the 33 patients treated with IVB, 2 patients (6%) had advanced macular ischemia with an FAZ enlarged by 50% or more. In both patients, the visual acuity did not worsen and the foveal thickness decreased.
  
  
  CONCLUSIONS
  It is possible that IVB led to macular ischemia.
authors.affiliation: Department of Ophthalmology, Hospital, National Center for Global Health and Medicine, Japan. yonakamu@hosp.ncgm.go.jp
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Nakamura
authors.forename: Norio
authors.initials: N
authors.lastname: Takeda
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Tatsumi
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Oshitari
authors.forename: Miyuki
authors.initials: M
authors.lastname: Arai
authors.forename: Yoko
authors.initials: Y
authors.lastname: Takatsuna
authors.forename: Yoshinori
authors.initials: Y
authors.lastname: Mitamura
authors.forename: Shuichi
authors.initials: S
authors.lastname: Yamamoto
mesh_terms: D000328:Adult; D000368:Aged; D061067:Antibodies, Monoclonal, Humanized / Q000008:administration & dosage* / Q000009:adverse effects*; D000068258:Bevacizumab; D048909:Diabetes Complications; D005260:Female; D006801:Humans; D058449:Intravitreal Injections; D007511:Ischemia / Q000139:chemically induced* / Q000503:physiopathology; D008266:Macula Lutea / Q000098:blood supply*; D008269:Macular Edema / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D014792:Visual Acuity
chemical_list: D061067:Antibodies, Monoclonal, Humanized; D000068258:Bevacizumab