title: Array CGH analysis shows that aneuploidy is not related to the number of embryos generated.
abstract: This study retrospectively analysed array comparative genomic hybridization (CGH) results of 7753 embryos from 990 patients to determine the frequency of embryonic euploidy and its relationship with the cohort size (i.e. the number of embryos available for biopsy and array CGH analysis). Linear regression analysis was performed to assess the effect of cohort size on euploidy rate adjusted for the effect of female age. While increasing female age was associated with a significant decrease in euploidy rate of day-3 and day-5 embryos (P<0.001 for both groups), cohort size was not significantly associated with euploidy rate. Logistic regression analysis was performed to assess the effect of cohort size, adjusted for maternal age, on the likelihood of having at least one euploid embryo available for transfer. The odds of having at least one euploid embryo in an assisted cycle was significantly decreased by increasing female age (P<0.01 for both day-3 and day-5 embryos) and was significantly increased by every additional embryo available for analysis (P<0.001 for both day-3 and day-5 embryos).
authors.affiliation: MUHC Reproductive Center, Div. of Reproductive Endocrinology and Infertility, Dept. of Obstetrics and Gynecology, McGill University, Montreal, Canada H3A 1A1.
authors.forename: Baris
authors.initials: B
authors.lastname: Ata
authors.forename: Brian
authors.initials: B
authors.lastname: Kaplan
authors.forename: Hal
authors.initials: H
authors.lastname: Danzer
authors.forename: Michael
authors.initials: M
authors.lastname: Glassner
authors.forename: Michael
authors.initials: M
authors.lastname: Opsahl
authors.forename: Seang Lin
authors.initials: SL
authors.lastname: Tan
authors.forename: Santiago
authors.initials: S
authors.lastname: Munné
mesh_terms: D000328:Adult; D000367:Age Factors; D000782:Aneuploidy; D001706:Biopsy; D001755:Blastocyst; D015331:Cohort Studies; D055028:Comparative Genomic Hybridization / Q000379:methods*; D004624:Embryo Transfer / Q000379:methods*; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D016014:Linear Models; D008423:Maternal Age; D011247:Pregnancy; D019836:Preimplantation Diagnosis / Q000379:methods*; D012189:Retrospective Studies