title: Successful liver transplantation for a child with life-threatening recurrent bleeding episodes due to congenital factor X deficiency: a case report.
abstract: Factor X (FX) deficiency is a rare, autosomal-recessive coagulation disorder. Diagnosis can be confirmed by a factor X assay. Although fresh frozen plasma and prothrombin complex concentrates have been used as a temporary treatment of bleeding symptoms and preparation for surgery, frequent transfusion has its risk and prothrombin complex is not available in Korea. We report the first pediatric case of successful liver transplantation for the correction of a severe congenital FX deficiency in a child with recurrent life-threatening hemorrhagic episodes.
authors.affiliation: Department of Pediatrics, Asan Medical Center Children's Hospital, and the Department of Surgery, University of Ulsan College of Medicine, Seoul, Korea.
authors.forename: S H
authors.initials: SH
authors.lastname: Bang
authors.forename: S H
authors.initials: SH
authors.lastname: Oh
authors.forename: K M
authors.initials: KM
authors.lastname: Kim
authors.forename: S M
authors.initials: SM
authors.lastname: Song
authors.forename: J J
authors.initials: JJ
authors.lastname: Seo
authors.forename: H W
authors.initials: HW
authors.lastname: Yoo
authors.forename: T H
authors.initials: TH
authors.lastname: Kim
authors.forename: D Y
authors.initials: DY
authors.lastname: Kim
authors.forename: S G
authors.initials: SG
authors.lastname: Lee
mesh_terms: D001777:Blood Coagulation / Q000235:genetics*; D001780:Blood Coagulation Tests; D004252:DNA Mutational Analysis; D005171:Factor X Deficiency / Q000097:blood / Q000150:complications / Q000175:diagnosis / Q000235:genetics / Q000601:surgery*; D005260:Female; D006470:Hemorrhage / Q000097:blood / Q000235:genetics / Q000517:prevention & control*; D006801:Humans; D007223:Infant; D016031:Liver Transplantation; D008297:Male; D012720:Severity of Illness Index; D016896:Treatment Outcome