title: A retrospective case review of isolated sinonasal amyloidosis.
abstract: OBJECTIVE
  We report an extremely rare case of isolated primary sinonasal amyloidosis.
  
  
  METHODS
  A case report and comprehensive literature review are presented. Common symptoms, signs and treatment options are examined, and used to derive an algorithm with which the practising otolaryngologist can diagnose and manage this condition.
  
  
  RESULTS
  Only 15 cases of true primary idiopathic amyloid restricted to the sinonasal tract have previously been reported. Isolated sinonasal amyloid presents with common rhinological symptoms which mimic chronic rhinosinusitis, i.e. nasal obstruction, nasal discharge, epistaxis, 'glue ear' and post-nasal drip. The lesion itself can appear as a simple inflammatory polyp. In children, the symptoms are easily attributed to enlarged adenoids. Although there is a concern that surgically induced trauma to the paranasal mucosa might incite reactive amyloid deposition, this seems not to be the case, and surgery provides symptomatic relief in the majority of patients.
  
  
  CONCLUSIONS
  This article is the first to report the characteristic features of isolated primary sinonasal amyloidosis. The evidence suggests that meticulous surgery can produce substantial symptomatic improvement in these patients.
authors.affiliation: Department of Otolaryngology Head and Neck Surgery, Concord Repatriation Hospital, New South Wales, South Australia, Australia. yuresh@med.usyd.edu.au
authors.forename: Y S
authors.initials: YS
authors.lastname: Naidoo
authors.forename: R
authors.initials: R
authors.lastname: Gupta
authors.forename: R
authors.initials: R
authors.lastname: Sacks
mesh_terms: D000465:Algorithms; D000686:Amyloidosis / Q000175:diagnosis* / Q000503:physiopathology / Q000601:surgery; D001706:Biopsy; D003937:Diagnosis, Differential; D004724:Endoscopy; D005260:Female; D006801:Humans; D008875:Middle Aged; D009297:Nasal Mucosa / Q000473:pathology*; D015508:Nasal Obstruction / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D009668:Nose Diseases / Q000175:diagnosis* / Q000503:physiopathology / Q000601:surgery; D010254:Paranasal Sinus Diseases / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery; D012008:Recurrence; D012086:Reoperation; D012189:Retrospective Studies; D012903:Smell; D000267:Tissue Adhesions / Q000175:diagnosis / Q000601:surgery