title: Effects of Gossypium herbaceam extract administration on the learning and memory function in the naturally aged rats: neuronal niche improvement.
abstract: Aging-associated cognitive impairment is an important health care issue since individuals with mild cognitive impairment are more likely to develop Alzheimer's disease. In the present study, the protective effect of Gossypium herbaceam extracts (GHE) on learning and memory impairment associated with aging were examined in vivo using Morris water maze and step through task. Furthermore, the antioxidant activity and neuroprotective effect of GHE was investigated with methods of histochemistry and biochemistry. These data showed that oral administration with GHE at the doses of 35, 70, and 140 mg/kg exerted an improved effect on the learning and memory impairment in aged rats. Subsequently, GHE afforded a beneficial action on eradication of free radicals without influence on the activity of glutathione peroxidase and superoxide dismutase. GHE treatment enhanced the expression levels of nerve growth factor. Meanwhile, proliferation of neural progenitor cells was elevated in hippocampus after treatment with GHE. Taken together, neurogenic niche improvement could be involved in the mechanism underlying neuroprotection of GHE against aging-associated cognitive impairment. These findings suggested that GHE might be a potential agent as cognitive-enhancing drugs that delay or halt mild cognitive impairment progression to Alzheimer's disease or treatment of aging-associated cognitive impairment.
authors.affiliation: Department of Pharmacology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Yanyong
authors.initials: Y
authors.lastname: Liu
authors.affiliation: Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, China.
authors.forename: Haji Akber
authors.initials: HA
authors.lastname: Aisa
authors.affiliation: Department of Pharmacology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Chao
authors.initials: C
authors.lastname: Ji
authors.affiliation: Department of Pharmacology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Nan
authors.initials: N
authors.lastname: Yang
authors.affiliation: State Key Laboratory for Bioactive Substances and Functions of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Haibo
authors.initials: H
authors.lastname: Zhu
authors.affiliation: Department of Pharmacology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
authors.forename: Pingping
authors.initials: P
authors.lastname: Zuo
mesh_terms: D000375:Aging / Q000187:drug effects*; D000704:Analysis of Variance; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D019208:Brain-Derived Neurotrophic Factor / Q000378:metabolism; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use; D004195:Disease Models, Animal; D000077265:Donepezil; D004305:Dose-Response Relationship, Drug; D005786:Gene Expression Regulation / Q000187:drug effects; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D003368:Gossypium; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D007189:Indans / Q000627:therapeutic use; D007859:Learning Disabilities / Q000188:drug therapy*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018782:Maze Learning / Q000187:drug effects; D008569:Memory Disorders / Q000188:drug therapy*; D020932:Nerve Growth Factor / Q000378:metabolism; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D008517:Phytotherapy / Q000379:methods*; D010880:Piperidines / Q000627:therapeutic use; D028321:Plant Preparations; D011597:Psychomotor Performance / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time / Q000187:drug effects; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D019208:Brain-Derived Neurotrophic Factor; D002800:Cholinesterase Inhibitors; D005904:Glial Fibrillary Acidic Protein; D007189:Indans; D010880:Piperidines; D028321:Plant Preparations; D008315:Malondialdehyde; D000077265:Donepezil; D020932:Nerve Growth Factor; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D010751:Phosphopyruvate Hydratase