title: Bilirubin levels and the burden of coronary atherosclerosis in patients with STEMI.
abstract: We investigated whether serum bilirubin level (a marker of heme oxygenase activity) is a predictor of high levels of SYNTAX score (SXscore) in patients with acute myocardial infarction. Patients (n = 281; male 77%; mean age 60 ± 12) who were admitted with ST-elevation myocardial infarctions (STEMIs) were enrolled. Patients were divided into 2 groups. Group 1 was defined as SXscore <22 and group 2 was defined as SXscore ≥22. Total bilirubin levels were significantly higher in the high-SXscore group than in the low-SXscore group (0.86 ± 0.42 vs 1.02 ± 0.51, P = .005). A significant correlation was detected between total bilirubin and SXscore (r = .42; P = .001). At multivariate analysis, total bilirubin (odds ratio: 1.86, 95% confidence interval 1.04-3.35; P = .038) was an independent risk factor for high SXscore in patients with STEMI. In conclusion, serum bilirubin level is independently associated with SXscore in patients with STEMI.
authors.affiliation: Department of Cardiology, Erciyes University School of Medicine, Kayseri, Turkey.
authors.forename: Omer
authors.initials: O
authors.lastname: Sahin
authors.forename: Mahmut
authors.initials: M
authors.lastname: Akpek
authors.forename: Deniz
authors.initials: D
authors.lastname: Elcik
authors.forename: Serhat
authors.initials: S
authors.lastname: Karadavut
authors.forename: Vedat
authors.initials: V
authors.lastname: Simsek
authors.forename: Murat
authors.initials: M
authors.lastname: Tulmac
authors.forename: Ozcan
authors.initials: O
authors.lastname: Orscelik
authors.forename: Bekir
authors.initials: B
authors.lastname: Calapkorur
authors.forename: Ali
authors.initials: A
authors.lastname: Ergin
authors.forename: Mehmet G
authors.initials: MG
authors.lastname: Kaya
mesh_terms: D000368:Aged; D001663:Bilirubin / Q000097:blood*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000097:blood*; D005260:Female; D006419:Heme Oxygenase (Decyclizing) / Q000097:blood; D051547:Heme Oxygenase-1 / Q000097:blood; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000097:blood
chemical_list: D006419:Heme Oxygenase (Decyclizing); D051547:Heme Oxygenase-1; C105245:heme oxygenase-2; D001663:Bilirubin