title: Spectrally selective 3D TSE imaging of phosphocreatine in the human calf muscle at 3 T.
abstract: Quantitative information about concentrations of several metabolites in human skeletal muscle can be obtained through localized (31)P magnetic resonance spectroscopy methods. However, these methods have shortcomings: long acquisition times, limited volume coverage, and coarse resolution. Significantly higher spatial and temporal resolution of imaging of single metabolites can be achieved through spectrally selective three-dimensional imaging methods. This study reports the implementation of a three-dimensional spectrally selective turbo spin-echo sequence, on a 3T clinical system, to map the concentration of phosphocreatine in the human calf muscle with significantly increased spatial resolution and in a clinically feasible scan time. Absolute phosphocreatine quantification was performed with the use of external phantoms after relaxation and flip angle correction of the turbo spin-echo voxel signal. The mean ± standard deviation of the phosphocreatine concentration measured in five healthy volunteers was 29.4 ± 2.5 mM with signal-to-noise ratio of 14:1 and voxel size of 0.52 mL.
authors.affiliation: Quantitative Multinuclear Musculoskeletal Imaging Group, Center for Biomedical Imaging, Department of Radiology, New York University Langone Medical Center, New York, New York 10016, USA. prodromos.parasoglou@nyumc.org
authors.forename: Prodromos
authors.initials: P
authors.lastname: Parasoglou
authors.forename: Ding
authors.initials: D
authors.lastname: Xia
authors.forename: Ravinder R
authors.initials: RR
authors.lastname: Regatte
mesh_terms: D000328:Adult; D000465:Algorithms; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D007866:Leg; D008279:Magnetic Resonance Imaging / Q000379:methods; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008297:Male; D057054:Molecular Imaging / Q000379:methods*; D018482:Muscle, Skeletal / Q000737:chemistry / Q000378:metabolism*; D010725:Phosphocreatine / Q000032:analysis*; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D010725:Phosphocreatine