title: Microwave-assisted synthesis and antioxidant properties of hydrazinyl thiazolyl coumarin derivatives.
abstract: BACKGROUND
  Coumarin derivatives exhibit a wide range of biological properties including promising antioxidant activity. Furthermore, microwave-assisted organic synthesis has delivered rapid routes to N- and O-containing heterocycles, including coumarins and thiazoles. Combining these features, the use of microwave-assisted processes will provide rapid access to a targeted coumarin library bearing a hydrazino pharmacophore for evaluation of antioxidant properties
  
  
  RESULTS
  Microwave irradiation promoted 3 of the 4 steps in a rapid, convergent synthesis of a small library of hydrazinyl thiazolyl coumarin derivatives, all of which exhibited significant antioxidant activity comparable to that of the natural antioxidant quercetin, as established by DPPH and ABTS radical assays
  
  
  CONCLUSIONS
  Microwave dielectric heating provides a rapid and expedient route to a series of hydrazinyl thiazolyl coumarins to investigate their radical scavenging properties. Given their favourable properties, in comparison with known antioxidants, these coumarin derivatives are promising leads for further development and optimization.
authors.affiliation: School of Chemical Sciences, Universiti Sains Malaysia, 11800, Penang, Malaysia. ohasnah@usm.my.
authors.forename: Hasnah
authors.initials: H
authors.lastname: Osman
authors.forename: Afsheen
authors.initials: A
authors.lastname: Arshad
authors.forename: Chan Kit
authors.initials: CK
authors.lastname: Lam
authors.forename: Mark C
authors.initials: MC
authors.lastname: Bagley