title: No association of genetic polymorphisms in CYP1B1 with primary open-angle glaucoma: a meta- and gene-based analysis.
abstract: OBJECTIVE
  To examine the effects of genetic polymorphisms in cytochrome P450, subfamily 1, polypeptide 1 (C1P1B1) on primary open-angle glaucoma (POAG).
  
  
  METHODS
  A systematic literature search was performed, and random-effects meta-analyses were used to evaluate genetic polymorphisms in CYP1B1 with POAG. A gene-based analysis was conducted to investigate the cumulative effects of genetic polymorphisms in CYP1B1.
  
  
  RESULTS
  A total of six studies from published papers were included in our analysis. Random-effects meta-analyses failed to detect any significant association of POAG with genetic polymorphisms in CYP1B1, including rs180040, rs1056836, rs10012, rs1056827, rs1056837, and rs2567206. The gene-based analysis indicated that the cumulative effect of genetic polymorphisms in CYP1B1 is not associated with POAG (p>0.50).
  
  
  CONCLUSIONS
  We did not find any evidence of strong association of POAG with CYP1B1 genetic polymorphisms and their cumulative effect.
authors.affiliation: Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
authors.forename: Shuqian
authors.initials: S
authors.lastname: Dong
authors.forename: Jingyun
authors.initials: J
authors.lastname: Yang
authors.forename: Weihong
authors.initials: W
authors.lastname: Yu
authors.forename: Pravina
authors.initials: P
authors.lastname: Kota
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Xia
authors.forename: Huizhuo
authors.initials: H
authors.lastname: Xu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001189:Aryl Hydrocarbon Hydroxylases / Q000235:genetics*; D044466:Asian People / Q000235:genetics*; D016022:Case-Control Studies; D065633:Cytochrome P-450 CYP1B1; D003627:Data Interpretation, Statistical; D016206:Databases, Bibliographic; D005902:Glaucoma, Open-Angle / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D009154:Mutation; D011110:Polymorphism, Genetic; D044465:White People / Q000235:genetics*
chemical_list: D001189:Aryl Hydrocarbon Hydroxylases; C585496:CYP1B1 protein, human; D065633:Cytochrome P-450 CYP1B1