title: [Correlations between chemokines CXCL12, CCL2, RANTES and early abortion].
abstract: OBJECTIVE
  To explore the correlations between chemokines stromal cell-derived factor-1 (CXCL12), monocyte chemotactic protein-1 (CCL2), regulated upon activation normal T cell expressed and secreted (RANTES) and early abortion.
  
  
  METHODS
  The villus and decidua tissues of recurrent spontaneous abortion group (n = 26), medical abortion group (n = 30) and normal early pregnancy women (control group, n = 30) were collected at our hospital from 2008 to 2009. And their expressions of CXCL12, CCL2, RANTES mRNA were determined by real-time fluorescence quantitative PCR (polymerase chain reaction).
  
  
  RESULTS
  The CXCL12, CCL2 and RANTES mRNA gene expressions were detected in first-trimester placental villus and decidua tissues. And the gene expressions of CXCL12 mRNA in villus and decidua tissues in spontaneous abortion and medical abortion groups were significantly lower than that in the control group (P < 0.01). But the gene expressions of CCL2 and RANTES mRNA in villus and decidua tissues were significantly higher than that in the control group (P < 0.01).
  
  
  CONCLUSIONS
  CXCL12, CCL2 and RANTES are co-expressed in human villus and decidua tissues. The lower CXCL12 mRNA expression and the higher expressions of CCL2 and RANTES mRNA play important roles in the pathogenesis of early abortion.
authors.affiliation: Department of Family Planning, Tianjin Medical University, Tianjin, China.
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yan
authors.initials: Y
authors.lastname: Gu
authors.forename: Jun-xia
authors.initials: JX
authors.lastname: Li
authors.forename: Yi
authors.initials: Y
authors.lastname: Li
mesh_terms: D000026:Abortion, Habitual / Q000378:metabolism; D000022:Abortion, Spontaneous / Q000378:metabolism*; D000328:Adult; D016022:Case-Control Studies; D018932:Chemokine CCL2 / Q000378:metabolism*; D018946:Chemokine CCL5 / Q000378:metabolism*; D054377:Chemokine CXCL12 / Q000378:metabolism*; D003656:Decidua / Q000378:metabolism*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011261:Pregnancy Trimester, First
chemical_list: C111835:CCL2 protein, human; C483024:CCL5 protein, human; C515255:CXCL12 protein, human; D018932:Chemokine CCL2; D018946:Chemokine CCL5; D054377:Chemokine CXCL12