title: The risk of gestational diabetes mellitus among Mexican women with a history of infertility and polycystic ovary syndrome.
abstract: OBJECTIVE
  To study the incidence of gestational diabetes mellitus (GDM) in Mexican women with a history of infertility and polycystic ovary syndrome (PCOS) compared with women without PCOS matched by age, pregestational body mass index (BMI), and parity.
  
  
  METHODS
  Historic cohort study.
  
  
  METHODS
  Level three medical institution.
  
  
  METHODS
  Group 1 (n = 52), women with a history of infertility and PCOS, and group 2 (n = 52), women without PCOS. Inclusion criteria were singleton pregnancy with ≤ 13 weeks of gestation. Exclusion criteria were pregestational diabetes mellitus and/or concomitant diseases.
  
  
  METHODS
  Diagnosis of GDM was based on a 3-hour, 100-g oral glucose tolerance test (GTT) performed during the second trimester.
  
  
  METHODS
  Incidence and relative risk (RR) for GDM.
  
  
  RESULTS
  The incidence of GDM was 26.9% and 9.6% for groups 1 and 2, respectively (RR = 2.8; 95% confidence interval 1.08-7.2). No other between-group differences were observed in the incidence of miscarriage, preterm birth, premature rupture of membranes, preeclampsia, stillbirth, fetal malformations, or small or large for gestational age newborns.
  
  
  CONCLUSIONS
  Pregnant Mexican women with a history of infertility and PCOS are at increased risk for developing GDM. This risk should be considered beginning early in the second trimester for a timely intervention and to improve the maternal-fetal prognosis.
authors.affiliation: Department of Endocrinology, National Institute of Perinatology, Mexico City, Mexico. dr.enriquereyes@gmail.com
authors.forename: Enrique
authors.initials: E
authors.lastname: Reyes-Muñoz
authors.forename: Guillermo
authors.initials: G
authors.lastname: Castellanos-Barroso
authors.forename: Brenda Y
authors.initials: BY
authors.lastname: Ramírez-Eugenio
authors.forename: Carlos
authors.initials: C
authors.lastname: Ortega-González
authors.forename: Adalberto
authors.initials: A
authors.lastname: Parra
authors.forename: Alfredo
authors.initials: A
authors.lastname: Castillo-Mora
authors.forename: Julio F
authors.initials: JF
authors.lastname: De la Jara-Díaz
mesh_terms: D000328:Adult; D015331:Cohort Studies; D016640:Diabetes, Gestational / Q000175:diagnosis / Q000208:ethnology*; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D015994:Incidence; D007247:Infertility, Female / Q000208:ethnology*; D008800:Mexico / Q000453:epidemiology; D011085:Polycystic Ovary Syndrome / Q000208:ethnology*; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D015995:Prevalence; D012307:Risk Factors