title: Modification of 15-akylidene andrographolide derivatives as alpha-glucosidase inhibitor.
abstract: 15-Alkylidene andrographolide derivatives were specific alpha-glucosidase inhibitors. Semi-synthetic studies of these derivatives led to new alpha-glucosidase inhibitors. Their alpha-glucosidase inhibitory activity was evaluated. Bioactivity results indicated that most of the derivatives were excellent alpha-glucosidase inhibitors. Among them, 6c displayed the best alpha-glucosidase inhibitory bioactivity with an <span lang="EN-US">IC(50) value of 8.3 </span><span lang="EN-US" style="font-size: 10.5pt; font-family: Symbol;">m</span><span lang="EN-US">M.</span>
authors.affiliation: New Drug Research & Development Center, Zhengzhou University, Zhengzhou, China.
authors.forename: H W
authors.initials: HW
authors.lastname: Xu
authors.forename: G Z
authors.initials: GZ
authors.lastname: Liu
authors.forename: G F
authors.initials: GF
authors.lastname: Dai
authors.forename: C L
authors.initials: CL
authors.lastname: Wu
authors.forename: H M
authors.initials: HM
authors.lastname: Liu