title: Development of strong Brønsted base catalysis: catalytic direct-type Mannich reactions of non-activated esters via a product-base mechanism.
abstract: A catalytic Mannich reaction of a simple ester with no activating functionality at the α-position via a product-base mechanism was reported. The desired Mannich adducts were obtained in high yields using a catalytic amount of KH. This is a rare example of a Brønsted base-catalyzed Mannich reaction of unactivated esters as substrates.
authors.affiliation: Department of Chemistry, School of Science, The University of Tokyo, Hongo, Tokyo 113-0033.
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Yamashita
authors.forename: Hirotsugu
authors.initials: H
authors.lastname: Suzuki
authors.forename: Shū
authors.initials: S
authors.lastname: Kobayashi