title: Isoleucine-catalyzed direct asymmetric aldol addition of enolizable aldehydes.
abstract: Isoleucine-catalyzed direct enantioselective aldol additions between enolizable aldehydes are reported. Intermediate acetal structures dictate the configurative outcome and were supported by a hydrogen bond. This direct isoleucine-catalyzed aldol addition represents a welcome complement to both proline- and histidine-catalyzed aldol additions of enolizable aldehydes.
authors.affiliation: Institute of Chemistry, Humboldt-University, Brook-Taylor Sr. 2, 12489 Berlin, Germany.
authors.forename: Kerstin
authors.initials: K
authors.lastname: Rohr
authors.forename: Rainer
authors.initials: R
authors.lastname: Mahrwald
mesh_terms: D000447:Aldehydes / Q000737:chemistry*; D002384:Catalysis; D006639:Histidine / Q000737:chemistry; D006860:Hydrogen Bonding; D007532:Isoleucine / Q000737:chemistry*; D008956:Models, Chemical; D011392:Proline / Q000737:chemistry; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D007532:Isoleucine; D006639:Histidine; C116609:3-hydroxybutanal; D011392:Proline