title: Preparation and characterization of new nano-composite scaffolds loaded with vascular stents.
abstract: In this study, vascular stents were fabricated from poly (lactide-ɛ-caprolactone)/collagen/nano-hydroxyapatite (PLCL/Col/nHA) by electrospinning, and the surface morphology and breaking strength were observed or measured through scanning electron microscopy and tensile tests. The anti-clotting properties of stents were evaluated for anticoagulation surfaces modified by the electrostatic layer-by-layer self-assembly technique. In addition, nano-composite scaffolds of poly (lactic-co-glycolic acid)/polycaprolactone/nano-hydroxyapatite (PLGA/PCL/nHA) loaded with the vascular stents were prepared by thermoforming-particle leaching and their basic performance and osteogenesis were tested in vitro and in vivo. The results show that the PLCL/Col/nHA stents and PLGA/PCL/nHA nano-composite scaffolds had good surface structures, mechanical properties, biocompatibility and could guide bone regeneration. These may provide a new way to build vascularized-tissue engineered bone to repair large bone defects in bone tissue engineering.
authors.affiliation: Institute of Prosthodontics , School of Stomatology, Tongji University, 399 Yanchang Road, Shanghai 200092, China.
authors.forename: Hongzhen
authors.initials: H
authors.lastname: Xu
authors.affiliation: Institute of Prosthodontics , School of Stomatology, Tongji University, 399 Yanchang Road, Shanghai 200092, China.
authors.forename: Jiansheng
authors.initials: J
authors.lastname: Su
authors.affiliation: Institute of Prosthodontics , School of Stomatology, Tongji University, 399 Yanchang Road, Shanghai 200092, China.
authors.forename: Jun
authors.initials: J
authors.lastname: Sun
authors.affiliation: Institute of Nano- and Bio-Polymeric Materials, School of Materials Science and Engineering, Tongji University, 1239 Siping Road, Shanghai 200092, China.
authors.forename: Tianbin
authors.initials: T
authors.lastname: Ren
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001807:Blood Vessel Prosthesis; D001854:Bone Marrow Cells / Q000166:cytology; D001861:Bone Regeneration; D002478:Cells, Cultured; D059630:Mesenchymal Stem Cells / Q000166:cytology; D008855:Microscopy, Electron, Scanning; D053761:Nanocomposites / Q000737:chemistry* / Q000648:ultrastructure; D011817:Rabbits; D015607:Stents; D023822:Tissue Engineering; D054457:Tissue Scaffolds / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials