title: [Thyroid cancer].
abstract: The thyroid glands are a vulnerable organ to ionizing radiation. Indeed the epidemiological studies have revealed an increase in the incidences of thyroid cancer among atomic bomb survivors in Hiroshima and Nagasaki and radiation casualties in Chernobyl. The carcinogenic risk for the thyroids is dependent on radiation dose, and higher in younger people. Recent advances in molecular biology contribute to clarify the mechanisms for thyroid carcinogenesis at genetic and molecular levels. Here radiation-induced thyroid carcinogenesis is reviewed from epidemiological data to basic research.
authors.affiliation: Department of Molecular Medicine, Radiation Life Science Unit, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Sciences.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Nagayama
mesh_terms: D047852:Chernobyl Nuclear Accident; D006801:Humans; D007564:Japan; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology; D054043:Nuclear Weapons; D013964:Thyroid Neoplasms / Q000453:epidemiology / Q000209:etiology*