title: Antiulcer activity of methanol extract of Melastoma malabathricum leaves in rats.
abstract: OBJECTIVE
  To determine the potential antiulcer activity of methanol extract of Melastoma malabathricum leaves (MEMM) using various established rat models.
  
  
  METHODS
  Ten groups of rats were used and orally administered 10% DMSO (negative control), 100 mg/kg ranitidine (positive control) or MEMM (50, 250 and 500 mg/kg) followed by gastric ulcer induction either using ethanol or indomethacin. The stomachs were collected and subjected to macroscopic and microscopic analyses.
  
  
  RESULTS
  MEMM exhibited significant (p < 0.05) antiulcer activity in the ethanol, but not in the indomethacin-induced gastric ulcer model. The percentage of antiulcer activity for 50-500 mg/kg MEMM ranged between 3 and 75%, respectively. The gross observations were supported by histological findings. MEMM also aggravated the indomethacin-induced gastric ulcer, leading to an increase in ulcer area formation and ulcer score.
  
  
  CONCLUSIONS
  The M. malabathricum leaves showed antiulcer activity, which could be attributed to their antioxidant and anti-inflammatory activities. This requires further in-depth studies.
authors.affiliation: Department of Biomedical Science, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia, Serdang, Malaysia.
authors.forename: Z
authors.initials: Z
authors.lastname: Zabidi
authors.forename: W N
authors.initials: WN
authors.lastname: Wan Zainulddin
authors.forename: S S
authors.initials: SS
authors.lastname: Mamat
authors.forename: S
authors.initials: S
authors.lastname: Shamsahal Din
authors.forename: F H
authors.initials: FH
authors.lastname: Kamisan
authors.forename: F
authors.initials: F
authors.lastname: Yahya
authors.forename: N A
authors.initials: NA
authors.lastname: Ismail
authors.forename: R
authors.initials: R
authors.lastname: Rodzi
authors.forename: H
authors.initials: H
authors.lastname: Hassan
authors.forename: N
authors.initials: N
authors.lastname: Mohtarrudin
authors.forename: M N
authors.initials: MN
authors.lastname: Somchit
authors.forename: Z A
authors.initials: ZA
authors.lastname: Zakaria
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005765:Gastrointestinal Agents / Q000008:administration & dosage / Q000494:pharmacology*; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D035322:Melastomataceae / Q000737:chemistry*; D000432:Methanol / Q000737:chemistry; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry; D011899:Ranitidine / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D014456:Ulcer / Q000188:drug therapy*
chemical_list: D005765:Gastrointestinal Agents; D010936:Plant Extracts; D011899:Ranitidine; D007213:Indomethacin; D000432:Methanol