title: Cell adhesion and glistening formation in hybrid copolymer intraocular lenses.
abstract: The purpose of this study is to investigate the cell adhesion and glistening formation properties of various foldable intraocular lenses (IOLs) in vitro. Three conventional hydrophobic methacrylate acrylic (MA) IOLs, a hydrophilic hydroxyethyl methacrylate (HEMA) IOL and a hybrid MA/HEMA copolymer IOL were investigated for immunologically activated cell adhesion and for formation of glistenings resulting from cavitation, by analysis of digital images using NIH Image J PC software. The MA IOLs exhibited a low level of adhering cells but a high level of glistening formation, the HEMA IOL exhibited the reverse tendency, and the MA/HEMA IOL exhibited a low level of both, thus indicating that hybrid MA/HEMA IOLs are less susceptible than HEMA IOLs to cell adhesion and less susceptible than MA IOLs to glistening formation.
authors.affiliation: Fujita Eye Clinic, Tokyo Medical University, Hachioji, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Fujita
authors.forename: Takao
authors.initials: T
authors.lastname: Tanaka
authors.forename: Akira
authors.initials: A
authors.lastname: Miyata
authors.forename: Maiko
authors.initials: M
authors.lastname: Hirose
authors.forename: Masahiko
authors.initials: M
authors.lastname: Usui
mesh_terms: D000180:Acrylic Resins; D002448:Cell Adhesion / Q000502:physiology*; D002452:Cell Count; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D007910:Lenses, Intraocular; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008689:Methacrylates; D011475:Prosthesis Failure; D014617:Vacuoles
chemical_list: D000180:Acrylic Resins; D008689:Methacrylates; C005044:hydroxyethyl methacrylate