title: Thyroid fine needle aspirate: a post-Bethesda update.
abstract: The Bethesda system for reporting thyroid cytopathology formulated in 2007 has standardized reporting of thyroid cytology specimens and streamlined management algorithms. Although 3 of the categories (benign, malignant, and nondiagnostic) are standardized and improved, the remaining 3 (follicular lesion of undetermined significance, follicular neoplasm, and suspicious for malignancy) remain fraught with interobserver variability and uncertainty regarding management algorithms. Recent and ongoing morphologic and molecular studies that aim to resolve these issues are summarized.
authors.affiliation: Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. boses@cshs.org
authors.forename: Shikha
authors.initials: S
authors.lastname: Bose
authors.forename: Ann E
authors.initials: AE
authors.lastname: Walts
mesh_terms: D018263:Adenocarcinoma, Follicular; D044963:Biopsy, Fine-Needle / Q000592:standards; D002277:Carcinoma; D002291:Carcinoma, Papillary; D004268:DNA-Binding Proteins / Q000235:genetics; D005260:Female; D006801:Humans; D020935:MAP Kinase Signaling System / Q000235:genetics; D008297:Male; D009687:Nuclear Proteins / Q000235:genetics; D015588:Observer Variation; D000072636:PAX8 Transcription Factor; D047495:PPAR gamma / Q000235:genetics; D051761:Paired Box Transcription Factors / Q000235:genetics; D011237:Predictive Value of Tests; D048493:Proto-Oncogene Proteins B-raf / Q000235:genetics; D000077273:Thyroid Cancer, Papillary; D013961:Thyroid Gland / Q000473:pathology*; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D016606:Thyroid Nodule / Q000175:diagnosis; D014178:Translocation, Genetic; D000070584:Tripartite Motif Proteins
chemical_list: D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D000072636:PAX8 Transcription Factor; D047495:PPAR gamma; D051761:Paired Box Transcription Factors; D048493:Proto-Oncogene Proteins B-raf; C083325:PAX8 protein, human; C064419:TRIM27 protein, human; D000070584:Tripartite Motif Proteins; C482119:BRAF protein, human