title: A complex Polycomb issue: the two faces of EZH2 in cancer.
abstract: In the April 1, 2012, issue of Genes & Development, Simon and colleagues (pp. 651-656) demonstrated that the disruption of Ezh2 in mice is sufficient to cause T-acute lymphoblastic leukemia (T-ALL). Moreover, in concert with concurrent studies, the authors revealed that similar mechanisms are involved in human T-ALL. These data contrast with previous findings showing that increased EZH2 activity promotes cancer.
authors.affiliation: Cancer Center, Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA. hock.hanno@mgh.harvard.edu
authors.forename: Hanno
authors.initials: H
authors.lastname: Hock
mesh_terms: D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism*; D011495:Histone-Lysine N-Methyltransferase / Q000378:metabolism*; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D004268:DNA-Binding Proteins; D014157:Transcription Factors; D011495:Histone-Lysine N-Methyltransferase