title: N-acetyl-L-cysteine inhibits marble-burying behavior in mice.
abstract: In the present study, we examined the effect of N-acetyl-L-cysteine (NAC), a glutamate-modulating agent, on marble-burying behavior in mice. Fluvoxamine (30 mg/kg, p.o.) and mirtazapine (3 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. Similarity, NAC (150 mg/kg, i.p.) significantly inhibited marble-burying behavior without affecting locomotor activity. On the other hand, the antioxidant α-tocopherol (10, 30, and 100 mg/kg, p.o.) had no effect on the marble-burying behavior. These results suggest that the glutamatergic system is involved in the marble-burying behavior, and NAC may be useful for treatment of OCD.
authors.affiliation: Department of Neuropharmacology, Faculty of Pharmaceutical Sciences, Fukuoka University, Jonan-ku, Japan. n-egashi@pharm.med.kyushu-u.ac.jp
authors.forename: Nobuaki
authors.initials: N
authors.lastname: Egashira
authors.forename: Atsunori
authors.initials: A
authors.lastname: Shirakawa
authors.forename: Moe
authors.initials: M
authors.lastname: Abe
authors.forename: Tomiko
authors.initials: T
authors.lastname: Niki
authors.forename: Kenichi
authors.initials: K
authors.lastname: Mishima
authors.forename: Katsunori
authors.initials: K
authors.lastname: Iwasaki
authors.forename: Ryozo
authors.initials: R
authors.lastname: Oishi
authors.forename: Michihiro
authors.initials: M
authors.lastname: Fujiwara
mesh_terms: D000111:Acetylcysteine / Q000494:pharmacology*; D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001008:Anxiety Disorders / Q000188:drug therapy*; D001522:Behavior, Animal / Q000187:drug effects*; D016666:Fluvoxamine / Q000494:pharmacology; D008297:Male; D008803:Mianserin / Q000031:analogs & derivatives / Q000494:pharmacology; D051379:Mice; D008813:Mice, Inbred ICR; D000078785:Mirtazapine; D009043:Motor Activity / Q000187:drug effects*; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy*; D024502:alpha-Tocopherol / Q000494:pharmacology
chemical_list: D014150:Antipsychotic Agents; D008803:Mianserin; D000078785:Mirtazapine; D024502:alpha-Tocopherol; D016666:Fluvoxamine; D000111:Acetylcysteine