title: Accurate measurement of oxygen consumption in children undergoing cardiac catheterization.
abstract: Oxygen consumption (VO(2) ) is an important part of hemodynamics using the direct Fick principle in children undergoing cardiac catheterization. Accurate measurement of VO(2) is vital. Obviously, any error in the measurement of VO(2) will translate directly into an equivalent percentage under- or overestimation of blood flows and vascular resistances. It remains common practice to estimate VO(2) values from published predictive equations. Among these, the LaFarge equation is the most commonly used equation and gives the closest estimation with the least bias and limits of agreement. However, considerable errors are introduced by the LaFarge equation, particularly in children younger than 3 years of age. Respiratory mass spectrometry remains the "state-of-the-art" method, allowing highly sensitive, rapid and simultaneous measurement of multiple gas fractions. The AMIS 2000 quadrupole respiratory mass spectrometer system has been adapted to measure VO(2) in children under mechanical ventilation with pediatric ventilators during cardiac catheterization. The small sampling rate, fast response time and long tubes make the equipment a unique and powerful tool for bedside continuous measurement of VO(2) in cardiac catheterization for both clinical and research purposes.
authors.affiliation: Division of Pediatric Cardiology, Stollery Children's Hospital, Department of Pediatrics, University of Alberta, Mazankowski Alberta Heart Institute, Edmonton, Alberta, Canada. Jia.Li@albertahealthservices.ca
authors.forename: Jia
authors.initials: J
authors.lastname: Li
mesh_terms: D006328:Cardiac Catheterization / Q000009:adverse effects / Q000379:methods*; D002302:Cardiac Output / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006330:Heart Defects, Congenital / Q000175:diagnosis* / Q000601:surgery; D006801:Humans; D008297:Male; D013058:Mass Spectrometry / Q000379:methods; D008991:Monitoring, Physiologic / Q000379:methods; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption / Q000502:physiology*; D011237:Predictive Value of Tests; D018570:Risk Assessment; D012680:Sensitivity and Specificity
chemical_list: D010100:Oxygen