title: Neither oxidized nor anti-oxidized low-density lipoprotein level is associated with atherosclerosis or mortality in hemodialysis patients.
abstract: It is anticipated that oxidized low-density lipoprotein (oxLDL) and anti-oxLDL are associated with atherosclerosis and mortality. However, data on this issue are controversial and limited. We aimed to investigate the effect of these two markers on the extent and progression of atherosclerosis and mortality in a group of hemodialysis patients. In this prospective observational study with a follow-up of 36 months, 124 hemodialysis patients were studied. Ninety-five patients underwent carotid intima media thickness (CA-IMT) measurement by B-Mode ultrasonography both at baseline and at the end of the study. oxLDL and anti-oxLDL were measured by enzyme-linked immunosorbent assay. The extent and progression of CA-IMT, along with overall and cardiovascular mortality, were assessed. The mean age at baseline was 54.0 ± 14.8 years, 57.3% male and 20% diabetic. The mean oxLDL and anti-oxLDL levels were 8.11 ± 3.16 mU/L and 1.30 ± 0.31, respectively. Baseline mean CA-IMT was 0.82 ± 0.20 mm. Fifteen patients died during a follow-up period of 28.5 ± 6.6 months, 11 from cardiovascular causes. Only oxLDL, not anti-oxLDL, was correlated with the extent of atherosclerosis at baseline. However, both had no role in the progression of atherosclerosis. Also, in unadjusted and adjusted models, both parameters were not associated with overall or cardiovascular mortality. Neither oxLDL nor anti-oxLDL level is associated with the progression of atherosclerosis or mortality in hemodialysis patients.
authors.affiliation: Division of Nephrology, School of Medicine, Ege University, Izmir, Turkey. dresevinc@yahoo.com
authors.forename: Ebru
authors.initials: E
authors.lastname: Sevinc Ok
authors.forename: Fatih
authors.initials: F
authors.lastname: Kircelli
authors.forename: Gulay
authors.initials: G
authors.lastname: Asci
authors.forename: Ekrem
authors.initials: E
authors.lastname: Altunel
authors.forename: Muhittin
authors.initials: M
authors.lastname: Ertilav
authors.forename: Savas
authors.initials: S
authors.lastname: Sipahi
authors.forename: Devrim
authors.initials: D
authors.lastname: Bozkurt
authors.forename: Soner
authors.initials: S
authors.lastname: Duman
authors.forename: Mehmet
authors.initials: M
authors.lastname: Ozkahya
authors.forename: Huseyin
authors.initials: H
authors.lastname: Toz
authors.forename: Ercan
authors.initials: E
authors.lastname: Ok
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D050197:Atherosclerosis / Q000097:blood* / Q000473:pathology; D059168:Carotid Intima-Media Thickness; D005260:Female; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D006435:Renal Dialysis / Q000009:adverse effects*; D015996:Survival Rate; D055815:Young Adult
chemical_list: D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein