title: Simple synthesis of β-trifluoromethylstyrenes using (E)-trimethyl-(3,3,3-trifluoroprop-1-enyl)silane.
abstract: (E)-trimethyl-(3,3,3-trifluoroprop-1-enyl)silane (1) was synthesized as a reagent for use in Hiyama cross-coupling reactions for the production of β-trifluoromethylstyrene derivatives. Cross-coupling of 1 with electronically diverse aryl iodides was achieved by treatment with CsF in the presence of catalytic amounts of palladium to afford the desired products in moderate to good yields.
authors.affiliation: Faculty of Pharmaceutical Sciences, Setsunan University, 45-1, Nagaotoge-cho, Hirakata 573-0101, Japan.
authors.forename: Masaaki
authors.initials: M
authors.lastname: Omote
authors.forename: Miyuu
authors.initials: M
authors.lastname: Tanaka
authors.forename: Akari
authors.initials: A
authors.lastname: Ikeda
authors.forename: Shiho
authors.initials: S
authors.lastname: Nomura
authors.forename: Atsushi
authors.initials: A
authors.lastname: Tarui
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Sato
authors.forename: Akira
authors.initials: A
authors.lastname: Ando
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D012821:Silanes / Q000737:chemistry*; D013237:Stereoisomerism; D013343:Styrenes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: C573735:(E)-trimethyl-(3,3,3-trifluoroprop-1-enyl)silane; D012821:Silanes; D013343:Styrenes; D010165:Palladium