title: Development of a biodegradable bone cement for craniofacial applications.
abstract: This study investigated the formulation of a two-component biodegradable bone cement comprising the unsaturated linear polyester macromer poly(propylene fumarate) (PPF) and crosslinked PPF microparticles for use in craniofacial bone repair applications. A full factorial design was employed to evaluate the effects of formulation parameters such as particle weight percentage, particle size, and accelerator concentration on the setting and mechanical properties of crosslinked composites. It was found that the addition of crosslinked microparticles to PPF macromer significantly reduced the temperature rise upon crosslinking from 100.3°C ± 21.6°C to 102.7°C ± 49.3°C for formulations without microparticles to 28.0°C ± 2.0°C to 65.3°C ± 17.5°C for formulations with microparticles. The main effects of increasing the particle weight percentage from 25 to 50% were to significantly increase the compressive modulus by 37.7 ± 16.3 MPa, increase the compressive strength by 2.2 ± 0.5 MPa, decrease the maximum temperature by 9.5°C ± 3.7°C, and increase the setting time by 0.7 ± 0.3 min. Additionally, the main effects of increasing the particle size range from 0-150 μm to 150-300 μm were to significantly increase the compressive modulus by 31.2 ± 16.3 MPa and the compressive strength by 1.3 ± 0.5 MPa. However, the particle size range did not have a significant effect on the maximum temperature and setting time. Overall, the composites tested in this study were found to have properties suitable for further consideration in craniofacial bone repair applications.
authors.affiliation: Department of Bioengineering, Rice University, Houston, Texas 77005, USA.
authors.forename: Allan M
authors.initials: AM
authors.lastname: Henslee
authors.forename: Dong-Ho
authors.initials: DH
authors.lastname: Gwak
authors.forename: Antonios G
authors.initials: AG
authors.lastname: Mikos
authors.forename: F Kurtis
authors.initials: FK
authors.lastname: Kasper
mesh_terms: D020341:Absorbable Implants; D001843:Bone Cements / Q000737:chemistry*; D019245:Compressive Strength; D003432:Cross-Linking Reagents / Q000737:chemistry; D005650:Fumarates / Q000737:chemistry*; D008422:Materials Testing; D010316:Particle Size; D011126:Polypropylenes / Q000737:chemistry*; D023822:Tissue Engineering
chemical_list: D001843:Bone Cements; D003432:Cross-Linking Reagents; D005650:Fumarates; D011126:Polypropylenes; C097850:poly(propylene fumarate)