title: Adrenergic stimulation-released histamine taken-up in adrenergic nerves induces endothelium-dependent vasodilation in rat mesenteric resistance arteries.
abstract: The present study investigated whether histamine was taken up by perivascular adrenergic nerves and released by periarterial nerve stimulation (PNS) to induce vascular responses. In rat mesenteric vascular beds treated with capsaicin to eliminate calcitonin gene-related peptide (CGRP)ergic vasodilation and with active tone, PNS (1 - 4 Hz) induced only adrenergic nerve-mediated vasoconstriction. Histamine treatment for 20 min induced PNS-induced vasoconstriction followed by vasodilation without affecting CGRP-induced vasodilation. Chlorpheniramine, guanethidine, combination of histamine and desipramine, and endothelium-removal abolished PNS-induced vasodilation in histamine-treated preparations. These results suggest that histamine taken up by and released from adrenergic nerves by PNS causes endothelium-dependent vasodilation in rat mesenteric arteries.
authors.affiliation: Department of Clinical Pharmaceutical Science, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan.
authors.forename: Yuto
authors.initials: Y
authors.lastname: Haruki
authors.forename: Shingo
authors.initials: S
authors.lastname: Takatori
authors.forename: Sayo
authors.initials: S
authors.lastname: Hattori
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Zamami
authors.forename: Toshihiro
authors.initials: T
authors.lastname: Koyama
authors.forename: Panot
authors.initials: P
authors.lastname: Tangsucharit
authors.forename: Hiromu
authors.initials: H
authors.lastname: Kawasaki
mesh_terms: D018663:Adrenergic Agents / Q000494:pharmacology*; D059331:Adrenergic Neurons / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism; D045462:Endothelium-Dependent Relaxing Factors / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008638:Mesenteric Arteries / Q000187:drug effects* / Q000378:metabolism; D009924:Organ Culture Techniques; D051381:Rats; D017208:Rats, Wistar; D014661:Vasoconstriction / Q000187:drug effects* / Q000502:physiology; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology
chemical_list: D018663:Adrenergic Agents; D045462:Endothelium-Dependent Relaxing Factors