title: [Measurement and clinical significance of serum monocyte chemoattractant protein-1 in patients with polymyosits/dermatomyosits].
abstract: OBJECTIVE
  To analyze the correlated clinical significance by testing the serum monocyte chemoattractant protein-1 (MCP-1) levels of patients with  polymyositis/dermatomyositis (PM/DM).
  
  
  METHODS
  The sera from 100 adult PM/DM patients, 20 patients with pulmonary infection and 42 healthy controls  were selected. The serum MCP-1 concentrations were detected by enzyme-linked immunosorbent assay (ELISA). The correlations between serum  MCP-1 levels and clinical features or laboratory examinations of PM/DM patients were investigated.
  
  
  RESULTS
  The serum levels of MCP-1 were (1 869 ±1 590) ng/L, (1 349±1 303) ng/L, (493±255) ng/L and (256±144) ng/L in PM/DM patients with interstitial lung disease (ILD) and without ILD, patients with  infectious lung disease and healthy controls, respectively. Serum MCP-1 levels in the PM/DM patients with ILD were significantly higher than those of the  PM/DM patients without ILD, patients with infectious lung disease and healthy controls (all P values<0.01). Significant correlations were found between the  elevated levels of serum MCP-1 and the presence of ILD in the patients with PM/DM (χ2=9.6, P<0.01). The sensitivity and specificity of serum abnormal  MCP-1 levels for ILD in the patients with PM/DM were 60.7% and 68.2%, respectively. The incidence of fever, arthritis, decreased %DL(CO) , erythrocyte  sedimentation rate (ESR), C-reactive protein (CRP) and serum ferritin were significantly higher in the MCP-1 raised group than in the MCP-1 normal  group (all P values<0.005). Additionally, Spearman rank correlation analysis showed that serum MCP-1 levels were positively correlated with serum  ferritin in peripheral blood in the patients with PM/DM.
  
  
  CONCLUSIONS
  The levels of serum MCP-1 are significantly elevated in PM/DM and it is significantly  associated with ILD complication, and may contribute to the early differentiation of ILD from lung infectious disease.
authors.affiliation: Department of Rheumatology, China-Japan Friendship Hospital, Beijing 100029, China.
authors.forename: Fang
authors.initials: F
authors.lastname: Chen
authors.forename: Xiao-ming
authors.initials: XM
authors.lastname: Shu
authors.forename: Dong-xue
authors.initials: DX
authors.lastname: Wang
authors.forename: Guo-chun
authors.initials: GC
authors.lastname: Wang
authors.forename: Xin
authors.initials: X
authors.lastname: Lu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018932:Chemokine CCL2 / Q000097:blood*; D003882:Dermatomyositis / Q000097:blood* / Q000150:complications; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000175:diagnosis / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011014:Pneumonia / Q000175:diagnosis; D017285:Polymyositis / Q000097:blood* / Q000150:complications; D055815:Young Adult
chemical_list: D018932:Chemokine CCL2