title: Osteoprotegerin, leptin and IL-6: association with silent myocardial ischemia in type 2 diabetes mellitus.
abstract: BACKGROUND
  Diabetic patients often exhibit severe, asymptomatic coronary artery disease (CAD). The relationship between osteoprotegerin (OPG), inflammatory markers and silent myocardial ischemia remains to be elucidated.
  
  
  METHODS
  We recruited 45 type 2 diabetic patients and 33 healthy controls and assessed them for silent myocardial ischemia (SMI) by myocardial perfusion imaging. Patient blood was tested for OPG, IL-6 and leptin concentrations.
  
  
  RESULTS
  OPG, leptin and IL-6 levels were found significantly elevated in diabetic patients (p < 0.001, p < 0.01, p < 0.05). Based on our classification of presence/absence of SMI in our diabetic group, we found that there was a significant association between SMI and the biomarkers IL-6 (p < 0.001), leptin (p < 0.001) and OPG (p < 0.05). In multivariate regression analyses, OPG was found to be significantly related to diabetes mellitus and to SMI. Age, sex and smoking increased the association between OPG and SMI.
  
  
  CONCLUSIONS
  High OPG, leptin and IL-6 levels are associated with the presence and severity of SMI in type 2 diabetic patients.
authors.affiliation: Department of Biochemistry, Namik Kemal University, 100.YilMah. Barbaros Cad, no. 132, Tekirdag, Turkey. savasguzel@yahoo.com
authors.forename: Savas
authors.initials: S
authors.lastname: Guzel
authors.forename: Arzu
authors.initials: A
authors.lastname: Seven
authors.forename: Ali
authors.initials: A
authors.lastname: Kocaoglu
authors.forename: Banu
authors.initials: B
authors.lastname: Ilk
authors.forename: Eda C
authors.initials: EC
authors.lastname: Guzel
authors.forename: Gamze V
authors.initials: GV
authors.lastname: Saracoglu
authors.forename: Aslan
authors.initials: A
authors.lastname: Celebi
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood* / Q000150:complications; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D003925:Diabetic Angiopathies / Q000097:blood*; D005080:Exercise Test; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D020738:Leptin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D017202:Myocardial Ischemia / Q000097:blood* / Q000150:complications; D055414:Myocardial Perfusion Imaging; D053244:Osteoprotegerin / Q000097:blood*; D012044:Regression Analysis
chemical_list: D015415:Biomarkers; C508600:IL6 protein, human; D015850:Interleukin-6; D020738:Leptin; D053244:Osteoprotegerin; C506030:TNFRSF11B protein, human