title: Cord blood intestinal fatty acid-binding protein (I-FABP) in full-term intrauterine growth restricted pregnancies.
abstract: OBJECTIVE
  To prospectively investigate cord blood concentrations of intestinal fatty acid-binding protein-[I-FABP, a useful marker in the early detection of necrotizing enterocolitis-(NEC)] in full-term intrauterine-growth-restricted-(IUGR, associated with NEC, regardless of gestational age) and appropriate-for-gestational-age-(AGA) pregnancies. We also aimed to determine cord blood I-FABP concentrations in IUGR cases with abnormal versus normal antenatal Doppler results and investigate a possible association with feeding intolerance or NEC.
  
  
  METHODS
  I-FABP concentrations were determined by ELISA in 154 mixed arteriovenous cord blood samples from IUGR (n = 50) and AGA (n = 104) singleton full-term infants.
  
  
  RESULTS
  Cord blood I-FABP concentrations did not differ between IUGR and AGA groups, as well as between IUGR infants with normal versus abnormal(however, lacking absent/ reversed end-diastolic umbilical artery flow) antenatal Doppler results. No infant presented with feeding intolerance or NEC. Customized centiles were lower in IUGR infants with abnormal versus normal antenatal Doppler results (p < 0.001).
  
  
  CONCLUSIONS
  Full-term IUGR infants present with normal cord blood I-FABP concentrations and do not seem to be at higher risk for developing feeding intolerance or NEC, including those with compromised fetal perfusion.
authors.affiliation: Neonatal Division, 2nd Department of Obstetrics and Gynecology, Athens University Medical School, Athens, Greece.
authors.forename: Despina D
authors.initials: DD
authors.lastname: Briana
authors.forename: Sofia
authors.initials: S
authors.lastname: Liosi
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Gourgiotis
authors.forename: Maria
authors.initials: M
authors.lastname: Boutsikou
authors.forename: Stavroula
authors.initials: S
authors.lastname: Baka
authors.forename: Antonios
authors.initials: A
authors.lastname: Marmarinos
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Hassiakos
authors.forename: Ariadne
authors.initials: A
authors.lastname: Malamitsi-Puchner
mesh_terms: D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D020345:Enterocolitis, Necrotizing / Q000097:blood / Q000209:etiology*; D004797:Enzyme-Linked Immunosorbent Assay; D050556:Fatty Acid-Binding Proteins / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D005317:Fetal Growth Retardation / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011446:Prospective Studies; D012016:Reference Values; D012307:Risk Factors; D047929:Term Birth; D016216:Ultrasonography, Prenatal; D014469:Umbilical Arteries / Q000000981:diagnostic imaging / Q000503:physiopathology
chemical_list: D015415:Biomarkers; D050556:Fatty Acid-Binding Proteins