title: Synthesis of heteroglycoclusters by using orthogonal chemoselective ligations.
abstract: Synthetic heteroglycoclusters are being subjected to increasing interest due to their potential to serve as selective ligands for carbohydrate-binding proteins. In this paper, we describe an expedient strategy to prepare cyclopeptides displaying well-defined distributions and combinations of carbohydrates. By using both oxime ligation and copper(I)-catalyzed alkyne-azide cycloaddition, two series of compounds bearing binary combinations of αMan, αFuc or βLac in an overall tetravalent presentation, and either 2:2 or 3:1 relative proportions, have been prepared.
authors.affiliation: Département de Chimie Moléculaire, UMR-CNRS 5250 & ICMG FR 2607, Université Joseph Fourier, PB 53, 38041 Grenoble Cedex 9, France.
authors.forename: Baptiste
authors.initials: B
authors.lastname: Thomas
authors.forename: Michele
authors.initials: M
authors.lastname: Fiore
authors.forename: Isabelle
authors.initials: I
authors.lastname: Bossu
authors.forename: Pascal
authors.initials: P
authors.lastname: Dumy
authors.forename: Olivier
authors.initials: O
authors.lastname: Renaudet