title: Expression, prognostic and predictive impact of VEGF and bFGF in non-small cell lung cancer.
abstract: Despite major advances in cancer therapeutics, the prognosis for lung cancer patients is still poor and the median survival for patients presenting with advanced non-small cell lung cancer (NSCLC) is only 8-10 months. Angiogenesis is an important biological process and a relatively early event during lung cancer pathogenesis. Anti-angiogenic agents are used in treating patients with NSCLC, and their molecular biomarkers are also being assessed to predict response. A better understanding of the biology of angiogenesis in NSCLC may reveal new targets for treating this malignancy. In this article, we review the expression and prognostic impact of the angiogenic growth factors, vascular endothelial growth factor and basic fibroblast growth factor, in NSCLC.
authors.affiliation: Hammoud Hospital University Medical Center, Saida, Lebanon.
authors.forename: Fadi S
authors.initials: FS
authors.lastname: Farhat
authors.forename: Arafat
authors.initials: A
authors.lastname: Tfayli
authors.forename: Najla
authors.initials: N
authors.lastname: Fakhruddin
authors.forename: Rami
authors.initials: R
authors.lastname: Mahfouz
authors.forename: Zaher K
authors.initials: ZK
authors.lastname: Otrock
authors.forename: Raafat S
authors.initials: RS
authors.lastname: Alameddine
authors.forename: Ahmad H
authors.initials: AH
authors.lastname: Awada
authors.forename: Ali
authors.initials: A
authors.lastname: Shamseddine
mesh_terms: D020533:Angiogenesis Inhibitors / Q000494:pharmacology / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism; D016222:Fibroblast Growth Factor 2 / Q000235:genetics* / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000378:metabolism; D011379:Prognosis; D015398:Signal Transduction / Q000187:drug effects; D042461:Vascular Endothelial Growth Factor A / Q000235:genetics* / Q000378:metabolism
chemical_list: D020533:Angiogenesis Inhibitors; D014408:Biomarkers, Tumor; D042461:Vascular Endothelial Growth Factor A; D016222:Fibroblast Growth Factor 2