title: Bipolar disorder ANK3 risk variant effect on sustained attention is replicated in a large healthy population.
abstract: Independent genome-wide association studies have implicated a common single nucleotide polymorphism within the ANK3 gene (rs10994336) in bipolar disorder (BD) susceptibility, thus establishing rs10994336 marker as a strong candidate predisposing genetic factor for BD. Furthermore, recent findings demonstrate that this variant impacts on cognitive functioning in BD patients, their unaffected relatives, and healthy controls by influencing sustained attention. Here, we aimed to replicate this finding in a large population-based sample of healthy young adults (n=1808). Sustained attention was evaluated using the Continuous Performance Test as in the original study and working memory was assessed with the n-back task. Individuals carrying the BD risk T-allele showed significantly reduced sensitivity in target detection, increased errors of commission, and atypical response latency variability. In addition, we confirmed the lack of an association between the rs10994336 variant and working memory, as well as general intellectual ability, suggesting a specific effect on the Continuous Performance Test performance.
authors.affiliation: University Mental Health Research Institute, National and Kapodistrian University of Athens, Athens, Greece.
authors.forename: Alex
authors.initials: A
authors.lastname: Hatzimanolis
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Smyrnis
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Avramopoulos
authors.forename: Costas N
authors.initials: CN
authors.lastname: Stefanis
authors.forename: Ioannis
authors.initials: I
authors.lastname: Evdokimidis
authors.forename: Nicholas C
authors.initials: NC
authors.lastname: Stefanis
mesh_terms: D000293:Adolescent; D017487:Ankyrins / Q000235:genetics*; D001288:Attention / Q000502:physiology*; D001714:Bipolar Disorder / Q000235:genetics* / Q000503:physiopathology*; D003071:Cognition; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005828:Genetics, Population; D006115:Greece; D006262:Health; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D015203:Reproducibility of Results; D055815:Young Adult
chemical_list: C490613:ANK3 protein, human; D017487:Ankyrins