title: Anti-depressant and anti-nociceptive effects of 1,4-benzodiazepine-2-ones based cholecystokinin (CCK(2)) antagonists.
abstract: Various 1,4-benzodiazepines were synthesized around a Diazepam, Oxazepam and the n-propyl-1,4-benzodiazepine template. SAR studies of CCK(2) binding affinity were performed and selected examples of each series were tested in vivo in mice. In addition to an anxiolytic effect, antidepressant effects were discovered using 8 standard CNS assays in mice. Finally, the cocomittant administration of the 1,4-benzodiazepine based CCK antagonists enhanced the response to pain with a low dose of morphine, significantly.
authors.affiliation: The School of Pharmacy, Aston University, Aston Triangle, Birmingham, England.
authors.forename: E
authors.initials: E
authors.lastname: Lattmann
authors.forename: J
authors.initials: J
authors.lastname: Sattayasai
authors.forename: P
authors.initials: P
authors.lastname: Lattmann
authors.forename: D C
authors.initials: DC
authors.lastname: Billington
authors.forename: C H
authors.initials: CH
authors.lastname: Schwalbe
authors.forename: J
authors.initials: J
authors.lastname: Boonprakob
authors.forename: W
authors.initials: W
authors.lastname: Airarat
authors.forename: H
authors.initials: H
authors.lastname: Singh
authors.forename: M
authors.initials: M
authors.lastname: Offel
authors.forename: A
authors.initials: A
authors.lastname: Staaf