title: Plasminogen activator inhibitor-1 is associated with renal dysfunction independent of BMI and serum lipid levels in patients with type 2 diabetes.
abstract: We investigated a possible association between serum plasminogen activator inhibitor-1 (PAI-1) levels and renal dysfunction in 124 type 2 diabetes patients. Multiple linear regression analyses indicated that the PAI-1 levels were significantly inversely correlated with estimated glomerular filtration rate (eGFR) independent of albuminuria, BMI, LDL-C, and triglyceride.
authors.affiliation: Department of Endocrinology and Metabolism, Graduate School of Medicine, Yokohama-City University, Yokohama, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Shirakawa
authors.forename: Yu
authors.initials: Y
authors.lastname: Togashi
authors.forename: Kazuki
authors.initials: K
authors.lastname: Tajima
authors.forename: Kazuki
authors.initials: K
authors.lastname: Orime
authors.forename: Kaori
authors.initials: K
authors.lastname: Kikuchi
authors.forename: Takashi
authors.initials: T
authors.lastname: Miyazaki
authors.forename: Koichiro
authors.initials: K
authors.lastname: Sato
authors.forename: Mari
authors.initials: M
authors.lastname: Kimura
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Goshima
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Terauchi
mesh_terms: D000419:Albuminuria / Q000378:metabolism; D044466:Asian People; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D008078:Cholesterol, LDL / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000503:physiopathology; D003928:Diabetic Nephropathies / Q000097:blood* / Q000503:physiopathology; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D016014:Linear Models; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D051437:Renal Insufficiency / Q000097:blood* / Q000503:physiopathology; D014280:Triglycerides / Q000097:blood
chemical_list: D015415:Biomarkers; D008078:Cholesterol, LDL; D008055:Lipids; D017395:Plasminogen Activator Inhibitor 1; D014280:Triglycerides