title: [Clinical curative effects of preoperative neoadjuvant chemotherapy on cervical cancer: analysis of 62 patients].
abstract: OBJECTIVE
  To explore the clinical curative effects of preoperative neoadjuvant chemotherapy (NACT) on locally advanced cervical cancer.
  
  
  METHODS
  A total of 62 patients of stage Ib2-IIb cervical cancer received neoadjuvant chemotherapy of paclitaxel plus cisplatin for 2 - 3 courses. The clinical curative effects were evaluated according to the changes of lesion size, intraoperative conditions and postoperative pathological reactions.
  
  
  RESULTS
  The overall response rate was 90.32% (56/62) and the complete response rate 30.65% (19/62). The tumor volumes decreased after NACT. The differences were significant (P < 0.05). After NACT, 56 patients undergoing radical hysterectomy recovered smoothly. The surgical resection rate was 90.32%. Chemotherapeutic reactions of cancerous tissue and a large number of infiltrated lymphocytes were seen in 50 cases. Lymph nodes were positive in 3 cases. There were parametrial invasion (n = 2) and vascular tumor emboli (n = 2).
  
  
  CONCLUSIONS
  Preoperative neoadjuvant chemotherapy is efficacious in cervical cancer. The parametrium becomes softer and the tumor staging decreases.
authors.affiliation: Department of Obstetrics & Gynecology, Hainan Hospital, Hainan Medical College, Haikou 570102, China. chaoman_he@163.com
authors.forename: Chao-Man
authors.initials: CM
authors.lastname: He
authors.forename: Feng-Bing
authors.initials: FB
authors.lastname: Liang
authors.forename: Man-Ling
authors.initials: ML
authors.lastname: Chen
authors.forename: Xiao-Mei
authors.initials: XM
authors.lastname: Wu
authors.forename: Song
authors.initials: S
authors.lastname: Jin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D020360:Neoadjuvant Therapy; D009367:Neoplasm Staging; D017239:Paclitaxel / Q000008:administration & dosage; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D055815:Young Adult
chemical_list: D017239:Paclitaxel; D002945:Cisplatin