title: Lewis acid-catalyzed intramolecular [3+2] cycloaddition of cyclopropane 1,1-diesters with alkynes for the synthesis of cyclopenta[c]chromene skeletons.
abstract: An efficient method to construct cyclopenta[c]chromene skeletons by Lewis acid-catalyzed intramolecular [3+2] cycloaddition of cyclopropane 1,1-diesters with alkynes is presented. Two new fused cycles can be formed in one step in moderate to excellent yields (up to 94 %), and the products can be converted into bioactive barbituric acid derivatives (1) under simple reaction conditions.
authors.affiliation: State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, PR China.
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Xia
authors.forename: Xian-Rong
authors.initials: XR
authors.lastname: Song
authors.forename: Xue-Yuan
authors.initials: XY
authors.lastname: Liu
authors.forename: Yong-Min
authors.initials: YM
authors.lastname: Liang
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis / Q000737:chemistry*; D001463:Barbiturates / Q000138:chemical synthesis / Q000737:chemistry; D001578:Benzopyrans / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D003521:Cyclopropanes / Q000138:chemical synthesis / Q000737:chemistry*; D058116:Lewis Acids / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000480:Alkynes; D001463:Barbiturates; D001578:Benzopyrans; D003521:Cyclopropanes; D058116:Lewis Acids; C030797:cyclopropane; C032232:barbituric acid