title: Acute simultaneous multiple lacunar infarcts: a severe disease entity in small artery disease.
abstract: BACKGROUND
  We hypothesized that acute simultaneous multiple lacunar infarcts (sMLI) may have different clinico-radiological characteristics compared to acute single lacunar infarcts (SLI).
  
  
  METHODS
  We retrospectively reviewed stroke patients with sMLI or SLI in a consecutively collected stroke registry with a predefined long-term clinical follow-up. Clinical characteristics, including vascular risk factors, rheological profiles, premorbid functional status, and clinical outcome were evaluated. In addition, radiological characteristics, including white matter ischemic changes, previous lacunes, microbleeds, and concomitant intra- or extracranial arterial stenosis were evaluated.
  
  
  RESULTS
  Of the 548 acute ischemic stroke patients, sMLI was found in 23 (13.5%) and SLI in 148 (86.5%). There was no difference in vascular risk factors and rheological profiles between the two groups, except for advanced age and more frequent previous history of stroke in the sMLI group. The sMLI group also showed more previous lacunes (p < 0.001) and microbleeds (p < 0.001). A cardioembolic or atherothrombotic stroke mechanism was rare in both groups. Recurrent strokes were more frequent in the sMLI group.
  
  
  CONCLUSIONS
  The main pathophysiology of sMLI may be small artery disease. However, clinico-radiological characteristics suggest that sMLI may be a more severe entity of small artery disease compared to SLI.
authors.affiliation: Department of Neurology, Konkuk University School of Medicine, Center for Geriatric Neuroscience Research, Institute of Biomedical Science and Technology, Research Institute of Biomedical Science, Seoul, Korea.
authors.forename: Joon Hwa
authors.initials: JH
authors.lastname: Lee
authors.forename: Young Jin
authors.initials: YJ
authors.lastname: Kim
authors.forename: Yeonsil
authors.initials: Y
authors.lastname: Moon
authors.forename: Hyun-Ji
authors.initials: HJ
authors.lastname: Cho
authors.forename: Hahn Young
authors.initials: HY
authors.lastname: Kim
mesh_terms: D000368:Aged; D001158:Arteries / Q000473:pathology*; D016009:Chi-Square Distribution; D038524:Diffusion Magnetic Resonance Imaging; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000209:etiology; D012189:Retrospective Studies; D012307:Risk Factors; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D059409:Stroke, Lacunar / Q000097:blood / Q000145:classification / Q000150:complications* / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed; D014652:Vascular Diseases / Q000097:blood / Q000150:complications* / Q000000981:diagnostic imaging