title: [Preliminary results of effectiveness of two schemes of controlled ovarian hyperstimulation protocols with recombinant foliculle stimulating hormone in intrauterine insemination cycles].
abstract: BACKGROUND
  The intrauterine insemination (IUI) is the first line treatment in different infertility situations.
  
  
  OBJECTIVE
  To compare the efficacy of two protocols of controlled ovarian hyper stimulation (COHS) with recombinant Follicle Stimulating hormone (rFSH) (75 vs. 150 UI/day) plus IUI, in terms of pregnancy rate, multiple pregnancies, ovarian hyper stimulation syndrome and ovarian stimulation features.
  
  
  METHODS
  Prospective study, sequential assignment, included 35 patients that had 44 cycles of IUI. They were assigned in to two groups, group 1 that started controlled ovarian hiperestimulation with 75 and 2 with 150 UI/day of recombinant rFSH.
  
  
  RESULTS
  We found statistically significant difference between groups in: dose of rFSH, amount of stimulation days, number of mature follicles and estradiol blood levels on the day of use of the GnRHant and hCG injection day. The pregnancy rate between group 1 and 2 were 9.1 vs. 27.2%, respectively. Of the 8 pregnancies, 75% were achieving in group 2. The twin pregnancy rate was 2.2% and there were no cases of OHSS.
  
  
  CONCLUSIONS
  Although without significant difference between groups we found a clear trend to achieve a better pregnancy rate with the 150 UI/day protocol without a significant raise in multiple pregnancy rate nor OHSS. The multifollicular development was associated to group 2 seems to be related to the better pregnancy rate achieved by the same group.
authors.affiliation: Servicio de Reproducción Asistida, Instituto Nacional de Perinatología, Montes Urales, DF México. jade57@prodigy.net.mx
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Barros Delgadillo
authors.forename: Rachel
authors.initials: R
authors.lastname: Fiszman Amora
authors.forename: Alvaro
authors.initials: A
authors.lastname: Santibañez Morales
authors.forename: Víctor
authors.initials: V
authors.lastname: Sánchez Solis
authors.forename: Fernando
authors.initials: F
authors.lastname: Gaviño Gaviño
mesh_terms: D000328:Adult; D005260:Female; D005640:Follicle Stimulating Hormone / Q000627:therapeutic use*; D006801:Humans; D007315:Insemination, Artificial / Q000379:methods*; D010062:Ovulation Induction / Q000379:methods*; D011446:Prospective Studies; D011994:Recombinant Proteins / Q000627:therapeutic use; D055815:Young Adult
chemical_list: D011994:Recombinant Proteins; D005640:Follicle Stimulating Hormone