title: Primary chemoradiotherapy for oral cavity squamous cell carcinoma.
abstract: OBJECTIVE
  To evaluate the survival of patients with oral cavity squamous cell carcinoma (SCC) treated with chemoradiotherapy (CRT) or radiotherapy (RT). To record the rate of osteoradionecrosis (ORN) and need for alternative feeding of patients with oral cavity cancer treated with CRT or RT.
  
  
  METHODS
  All patients with first presentation of oral cavity SCC treated with CRT or RT only at the Royal Brisbane & Women's Hospital (RBWH) between 2000 and 2007 were included. Patient Demographics (age, sex), ACE-27 Co-morbidity index, Staging (TNM staging system), Type of Chemotherapy and Dose of RT, Overall Survival (OS) and Disease-Specific Survival (DSS), Attempt at Salvage, development of distant metastases, development of ORN and success of treatment for ORN and requirement for alternative feeding (PEG/NGT) were recorded.
  
  
  RESULTS
  Fifty-four patients met the inclusion criteria. One patient died due to toxicity of treatment. The 5-year OS was 29%. The 5-year DSS was 30%. The rate of ORN amongst survivors was 36%.
  
  
  CONCLUSIONS
  CRT is successful in a small number of patients with oral cavity SCC. When compared to the published literature, surgery with or without post-operative RT has better survival rates. Salvage surgery does not appear to be a viable option for management of recurrence post CRT. The consequences of treatment, namely ORN and need for alternative feeding, are high.
authors.affiliation: Maxillofacial Unit, Royal Brisbane & Women's Hospital, Butterfield Street, Herston, Qld 4029, Australia; The University of Queensland, School of Dentistry, Brisbane, Qld 4000, Australia; The University of Queensland, Centre for Clinical Research, Herston, Qld 4029, Australia. Electronic address: anthony.crombie@gmail.com.
authors.forename: Anthony K
authors.initials: AK
authors.lastname: Crombie
authors.affiliation: The University of Queensland, School of Dentistry, Brisbane, Qld 4000, Australia; The University of Queensland, Centre for Clinical Research, Herston, Qld 4029, Australia.
authors.forename: Camile
authors.initials: C
authors.lastname: Farah
authors.affiliation: Department of Radiation Oncology, Cancer Care Services, Royal Brisbane & Women's Hospital, Butterfield Street, Herston, Qld 4029, Australia.
authors.forename: Lee
authors.initials: L
authors.lastname: Tripcony
authors.affiliation: Department of Radiation Oncology, Cancer Care Services, Royal Brisbane & Women's Hospital, Butterfield Street, Herston, Qld 4029, Australia.
authors.forename: Graeme
authors.initials: G
authors.lastname: Dickie
authors.affiliation: Maxillofacial Unit, Royal Brisbane & Women's Hospital, Butterfield Street, Herston, Qld 4029, Australia; The University of Queensland, School of Dentistry, Brisbane, Qld 4000, Australia.
authors.forename: Martin D
authors.initials: MD
authors.lastname: Batstone
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000628:therapy*; D059248:Chemoradiotherapy / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000628:therapy*; D010025:Osteoradionecrosis / Q000209:etiology*; D011878:Radiotherapy / Q000009:adverse effects*; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome