title: Fungal origins of the bicyclo[2.2.2]diazaoctane ring system of prenylated indole alkaloids.
abstract: Over eight different families of natural products consisting of nearly 70 secondary metabolites that contain the bicyclo[2.2.2]diazaoctane ring system have been isolated from various Aspergillus, Penicillium, and Malbranchea species. Since 1968, these secondary metabolites have been the focus of numerous biogenetic, synthetic, taxonomic, and biological studies and, as such, have made a lasting impact across multiple scientific disciplines. This review covers the isolation, biosynthesis, and biological activity of these unique secondary metabolites containing the bridging bicyclo[2.2.2]diazaoctane ring system. Furthermore, the diverse fungal origin of these natural products is closely examined and, in many cases, updated to reflect the currently accepted fungal taxonomy.
authors.affiliation: Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, USA.
authors.forename: Jennifer M
authors.initials: JM
authors.lastname: Finefield
authors.forename: Jens C
authors.initials: JC
authors.lastname: Frisvad
authors.forename: David H
authors.initials: DH
authors.lastname: Sherman
authors.forename: Robert M
authors.initials: RM
authors.lastname: Williams
mesh_terms: D001230:Aspergillus / Q000737:chemistry*; D001688:Biological Products; D026121:Indole Alkaloids; D015394:Molecular Structure; D054876:Prenylation
chemical_list: D001688:Biological Products; D026121:Indole Alkaloids