title: Development of mesoporous silica nanomaterials as a vehicle for anticancer drug delivery.
abstract: The development of delivery vehicles that would carry therapeutic agents selectively to cancer cells has become an important focus in biomedical research. Nanoparticles have received much attention because the advances made in this field have resulted in multiple biocompatible materials. In particular, mesoporous silica nanoparticles (MSNs) offer a solid framework with porous structure and high surface area that allows for the attachment of different functional groups. In this article we discuss the different surface modifications made to MSNs that have allowed for the construction of targeted nanoparticles to enhance accumulation and uptake in target sites, the incorporation of nanomachines for controlled cargo release and the combination with superparamagnetic metals for MRI cell labeling. We also discuss biocompatibility, biodistribution and drug-delivery efficacy of MSNs. Finally, we mention the construction of multifunctional nanoparticles that combine all of the previously examined nanoparticle modifications.
authors.affiliation: Department of Microbiology, Immunology & Molecular Genetics, California NanoSystems Institute, Jonsson Comprehensive Cancer Center, University of California, 405 Hilgard Avenue, Los Angeles, CA 90095, USA.
authors.forename: Rolando E
authors.initials: RE
authors.lastname: Yanes
authors.forename: Fuyuhiko
authors.initials: F
authors.lastname: Tamanoi
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage*; D005089:Exocytosis; D006863:Hydrogen-Ion Concentration; D060526:Magnetic Fields; D053758:Nanoparticles / Q000008:administration & dosage*; D014677:Pharmaceutical Vehicles / Q000008:administration & dosage*; D016062:Porosity; D012822:Silicon Dioxide / Q000008:administration & dosage*
chemical_list: D000970:Antineoplastic Agents; D014677:Pharmaceutical Vehicles; D012822:Silicon Dioxide