title: Synthesis and antimicrobial studies of some novel bis-[1,3,4]thiadiazole and bis-thiazole pendant to thieno[2,3-b]thiophene moiety.
abstract: The synthetic utility of 3,3'-(3,4-dimethylthieno[2,3-b]thiophene-2,5-diyl)bis (3-oxopropanenitrile) (1) in the synthesis of some novel bis-[1,3,4-thiadiazole] 6a-g and bis-thiazole 10 and 13 derivatives with thieno[2,3-b]thiophene moiety is reported. Antimicrobial evaluation of some selected examples from the synthesized products was carried out and showed promising results.
authors.affiliation: Department of Chemistry, Faculty of Science, Cairo University, Giza 12613, Egypt.|On leave to Department of Pharmaceutical Chemistry, Faculty of Pharmacy, King Khalid University, P. O. Box 418 Abha 61431, Saudi Arabia.
authors.forename: Nabila Abdelshafy
authors.initials: NA
authors.lastname: Kheder
authors.affiliation: Department of Chemistry, Faculty of Science, King Saud University, P. O. Box 2455 Riyadh 11451, Saudi Arabia.
authors.forename: Yahia Nasser
authors.identifier: 0000-0002-9762-0323
authors.initials: YN
authors.lastname: Mabkhot
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001232:Aspergillus fumigatus / Q000187:drug effects; D001412:Bacillus subtilis / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D003022:Clotrimazole / Q000494:pharmacology; D015195:Drug Design; D004926:Escherichia coli / Q000187:drug effects; D005848:Geotrichum / Q000187:drug effects; D017964:Itraconazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D010400:Penicillin G / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013307:Streptomycin / Q000494:pharmacology; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013876:Thiophenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D013830:Thiadiazoles; D013876:Thiophenes; C058949:1,3,4-thiadiazole; D017964:Itraconazole; D003022:Clotrimazole; D010400:Penicillin G; D013307:Streptomycin