title: Gonadoblastoma in the ovaries of a lesser galago (Galago senegalensis braccatus).
abstract: An enlarged right ovary was removed from a 14-year-old lesser galago (Galago senegalensis braccatus). Cytological preparations consisted of a heterogeneous population of neoplastic cells admixed with extracellular hyaline structures and cell-free nuclei. Microscopically, the ovary was replaced with gonadoblastoma and was composed of nests of germinal cells, including large oocyte-like cells, and sex cord-stromal cells arranged in palisading patterns around the germinal cells, the periphery of the nests and around extracellular hyaline material. The animal died 2 years after initial diagnosis. Necropsy examination revealed gonadoblastoma in the left ovary. The germinal cells of the tumour in the right and left ovaries were immunoreactive for calretinin, OCT3/4, PGP 9.5, Ki67 and/or faintly for cytokeratins. Sex cord-stromal cells were immunoreactive for calretinin, OCT3/4, GATA-4, E-cadherin and vimentin. Luteinized sex cord-stromal cells were immunoreactive for inhibin-alpha. The extracellular hyaline material was immunoreactive for laminin. This is the first case of gonadoblastoma in a non-human primate.
authors.affiliation: Department of Pathology, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA. irizarryar@lilly.com
authors.forename: A R
authors.initials: AR
authors.lastname: Irizarry Rovira
authors.forename: S
authors.initials: S
authors.lastname: Lynch
authors.forename: M
authors.initials: M
authors.lastname: David
authors.forename: J A
authors.initials: JA
authors.lastname: Ramos Vara
mesh_terms: D000818:Animals; D000836:Animals, Zoo; D014408:Biomarkers, Tumor / Q000378:metabolism; D017809:Fatal Outcome; D005260:Female; D005701:Galago; D018238:Gonadoblastoma / Q000378:metabolism / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D007797:Laminin / Q000378:metabolism; D010051:Ovarian Neoplasms / Q000378:metabolism / Q000473:pathology / Q000601:surgery / Q000662:veterinary*
chemical_list: D014408:Biomarkers, Tumor; D007797:Laminin