title: Thrombosis and acute leukemia.
abstract: Thrombosis is a common complication in patients with acute leukemia. While the presence of central venous lines, concomitant steroids, the use of Escherichia coli asparaginase and hereditary thrombophilic abnormalities are known risk factors for thrombosis  in children, information on the pathogenesis, risk factors, and clinical outcome of thrombosis in adult patients with acute lymphoid leukemia (ALL) or acute myeloid leukemia (AML) is still scarce. Expert consensus and guidelines regarding leukemia-specific risk factors, thrombosis prevention,  and treatment strategies, as well as optimal type of central venous catheter in acute leukemia patients are required. It is likely that each subtype of acute leukemia represents a different setting for the development of thrombosis and the risk of bleeding. This is perhaps due to a combination  of different disease-specific pathogenic mechanisms of thrombosis, including the type of chemotherapy protocol chosen, the underlying patients health, associated risk factors, as well as the biology of the disease itself. The risk of thrombosis may also vary according to ethnicity and prevalence  of hereditary risk factors for thrombosis; thus, it is advisable for Latin American, Asian, and African countries to report on their specific patient population.
authors.affiliation: Clínica de Leucemia Aguda, Departamento de Hematología y Oncología, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico. erickerickmx@yahoo.com.mx
authors.forename: Erick
authors.initials: E
authors.lastname: Crespo-Solís
mesh_terms: D000328:Adult; D001215:Asparaginase / Q000009:adverse effects; D002405:Catheterization, Central Venous / Q000009:adverse effects; D002648:Child; D004926:Escherichia coli / Q000201:enzymology; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications*; D012307:Risk Factors; D019851:Thrombophilia / Q000150:complications; D013927:Thrombosis / Q000209:etiology* / Q000517:prevention & control / Q000628:therapy
chemical_list: D001215:Asparaginase