title: Development of human locomotion.
abstract: Neural control of locomotion in human adults involves the generation of a small set of basic patterned commands directed to the leg muscles. The commands are generated sequentially in time during each step by neural networks located in the spinal cord, called Central Pattern Generators. This review outlines recent advances in understanding how motor commands are expressed at different stages of human development. Similar commands are found in several other vertebrates, indicating that locomotion development follows common principles of organization of the control networks. Movements show a high degree of flexibility at all stages of development, which is instrumental for learning and exploration of variable interactions with the environment.
authors.affiliation: Department of Systems Medicine, Neuroscience Section, University of Rome Tor Vergata, Via Montpellier 1, 00133 Rome, Italy. lacquaniti@caspur.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Lacquaniti
authors.forename: Yuri P
authors.initials: YP
authors.lastname: Ivanenko
authors.forename: Myrka
authors.initials: M
authors.lastname: Zago
mesh_terms: D002490:Central Nervous System / Q000166:cytology* / Q000502:physiology*; D006801:Humans; D008124:Locomotion / Q000502:physiology*; D009046:Motor Neurons / Q000502:physiology*; D009415:Nerve Net / Q000502:physiology*