title: Nucleophilic addition of β-amino carbanions to arynes: one-pot synthesis of 4-aryl-N-methyl-1,2,3,4-tetrahydroisoquinolines.
abstract: A novel approach for the direct C-4 arylation of N-methyl-1,2,3,4-tetrahydroisoquinolines by nucleophilic addition of β-aminocarbanions to benzynes is described which provides a one-pot procedure for synthesis of the title compounds.
authors.affiliation: Department of Chemistry, Panjab University, Chandigarh-160014, India. kns@pu.ac.in
authors.forename: Kamal Nain
authors.initials: KN
authors.lastname: Singh
authors.forename: Paramjit
authors.initials: P
authors.lastname: Singh
authors.forename: Pushpinder
authors.initials: P
authors.lastname: Singh
authors.forename: Yadwinder Singh
authors.initials: YS
authors.lastname: Deol
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D013237:Stereoisomerism; D044005:Tetrahydroisoquinolines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D044005:Tetrahydroisoquinolines