title: Plasma cell hepatitis (de-novo autoimmune hepatitis) developing post liver transplantation.
abstract: OBJECTIVE
  Cases of de-novo autoimmune hepatitis/plasma cell hepatitis (PCH) are increasingly being diagnosed by liver transplant centers. Its pathogenesis is poorly understood but this entity appears to be a variant of rejection. Herein, we review recent clinical reports of patients developing PCH.
  
  
  RESULTS
  Histologically, PCH is a challenging diagnosis, especially in the setting of recurrent hepatitis C and, in some cases, can be mistaken for acute cellular rejection. Recent case reports and case-control studies have shown that interferon appears to trigger PCH in hepatitis C posttransplant patients. Optimization of the immunosuppression regimen was found to prevent the development of PCH. In the nonhepatitis C posttransplant patient, tacrolimus-based immunosuppression appears to have some protective effect from PCH development. A combination therapy of cyclosporine and everolimus has also been shown to be effective in treating PCH.
  
  
  CONCLUSIONS
  PCH is a variant of rejection and is a cause of late graft loss post liver transplantation, especially in patients with hepatitis C. It should be part of the differential diagnosis of abnormal liver enzyme tests occurring in the post-liver transplant setting.
authors.affiliation: The Lillian and Henry M. Stratton-Hans Popper Department of Pathology, The Mount Sinai Medical Center, Mount Sinai School of Medicine, New York, New York, USA. mariaisabel.fiel@mountsinai.org
authors.forename: M Isabel
authors.initials: MI
authors.lastname: Fiel
authors.forename: Thomas D
authors.initials: TD
authors.lastname: Schiano
mesh_terms: D006084:Graft Rejection / Q000175:diagnosis / Q000276:immunology / Q000473:pathology; D006526:Hepatitis C / Q000150:complications / Q000601:surgery*; D019693:Hepatitis, Autoimmune / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D006801:Humans; D008099:Liver / Q000276:immunology / Q000473:pathology / Q000601:surgery; D016031:Liver Transplantation / Q000009:adverse effects*; D010950:Plasma Cells / Q000276:immunology* / Q000473:pathology