title: Preparation and in vitro evaluation of an ilomastat microemulsion gel by a self-microemulsifying system.
abstract: The purpose of this study was to construct a microemulsion gel formulation by a self-microemulsifying system for transdermal topical delivery of ilomastat. The optimum formulations were screened by penetration evaluation in vitro. Ilomastat microemulsion gel was prepared by drawing a ternary phase diagram and Pluronic F127 was added as gel matrix for the formulation. The optimal formulations had wide microemulsion existent field and good self-microemulsifying efficiency. The droplet size was within 100 nm. Statistical comparison of the permeation throughout 24 h showed that the two microemulsion gel preparations of ilomastat provided higher permeation than that of the normal gel which had only a low cumulative amount of ilomastat (6.03 microg x cm(-2)) 24 h after application. Cumulative amount of ilomastat from microemulsion gels A and B was 2.2 times and 1.8 times that of the normal gel at 24 h respectively. These results indicate that the microemulsion gel may be a promising vehicle for topical delivery of ilomastat.
authors.affiliation: Department of Pharmaceutics, Beijing Institute of Pharmacology & Toxicology, Beijing, China.
authors.forename: Li
authors.initials: L
authors.lastname: Senhao
authors.forename: Quan
authors.initials: Q
authors.lastname: Dongqin
mesh_terms: D000279:Administration, Cutaneous; D000465:Algorithms; D000818:Animals; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D004563:Electrochemistry; D004655:Emulsions; D005782:Gels; D006877:Hydroxamic Acids; D066298:In Vitro Techniques; D007202:Indicators and Reagents; D007211:Indoles / Q000008:administration & dosage* / Q000737:chemistry*; D051379:Mice; D008819:Mice, Nude; D009821:Oils / Q000737:chemistry; D010316:Particle Size; D010539:Permeability; D020442:Poloxamer; D012869:Skin Absorption; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D013501:Surface-Active Agents; D014867:Water / Q000737:chemistry
chemical_list: D004655:Emulsions; D005782:Gels; D006877:Hydroxamic Acids; D007202:Indicators and Reagents; D007211:Indoles; D009821:Oils; D013501:Surface-Active Agents; D014867:Water; D020442:Poloxamer; C119203:ilomastat