title: Humanized mice: current states and perspectives.
abstract: The development of chimeric mice bearing the components of a human immune system to serve as animal models for "human" diseases has been the goal of many years of research. In this review we will discuss the latest advances in this field, their remaining shortcomings and challenges to the generation of new models of mouse/human chimeras.
authors.affiliation: Institut Pasteur, Unité de Biologie des Populations Lymphocytaires, CNRS URA 1961, 25 rue du Dr Roux, 75724 Paris Cedex 015, France. sylvie.garcia@pasteur.fr
authors.forename: Sylvie
authors.initials: S
authors.lastname: Garcia
authors.forename: Antonio A
authors.initials: AA
authors.lastname: Freitas
mesh_terms: D000818:Animals; D002678:Chimera / Q000235:genetics / Q000276:immunology*; D004195:Disease Models, Animal; D005333:Fetus; D005544:Forecasting; D018703:Founder Effect; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000276:immunology; D006801:Humans; D007107:Immune System; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology*; D051379:Mice; D008822:Mice, Transgenic / Q000235:genetics / Q000276:immunology*; D023421:Models, Animal; D014183:Transplantation, Heterologous