title: Designing organometallic compounds for catalysis and therapy.
abstract: Bioorganometallic chemistry is a rapidly developing area of research. In recent years organometallic compounds have provided a rich platform for the design of effective catalysts, e.g. for olefin metathesis and transfer hydrogenation. Electronic and steric effects are used to control both the thermodynamics and kinetics of ligand substitution and redox reactions of metal ions, especially Ru(II). Can similar features be incorporated into the design of targeted organometallic drugs? Such complexes offer potential for novel mechanisms of drug action through incorporation of outer-sphere recognition of targets and controlled activation features based on ligand substitution as well as metal- and ligand-based redox processes. We focus here on η(6)-arene, η(5)-cyclopentadienyl sandwich and half-sandwich complexes of Fe(II), Ru(II), Os(II) and Ir(III) with promising activity towards cancer, malaria, and other conditions.
authors.affiliation: Department of Chemistry, University of Warwick, Gibbet Hill Road, Coventry CV4 7AL, UK.
authors.forename: Anna Louisa
authors.initials: AL
authors.lastname: Noffke
authors.forename: Abraha
authors.initials: A
authors.lastname: Habtemariam
authors.forename: Ana M
authors.initials: AM
authors.lastname: Pizarro
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Sadler
mesh_terms: D000962:Antimalarials / Q000737:chemistry / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000737:chemistry / Q000627:therapeutic use; D002384:Catalysis; D056831:Coordination Complexes / Q000737:chemistry* / Q000627:therapeutic use; D006801:Humans; D007700:Kinetics; D008288:Malaria / Q000188:drug therapy; D009369:Neoplasms / Q000188:drug therapy; D009942:Organometallic Compounds / Q000737:chemistry*; D013816:Thermodynamics
chemical_list: D000962:Antimalarials; D000970:Antineoplastic Agents; D056831:Coordination Complexes; D009942:Organometallic Compounds