title: Differential dorso-ventral distributions of Kv4.2 and HCN proteins confer distinct integrative properties to hippocampal CA1 pyramidal cell distal dendrites.
abstract: The dorsal and ventral regions of the hippocampus perform different functions. Whether the integrative properties of hippocampal cells reflect this heterogeneity is unknown. We focused on dendrites where most synaptic input integration takes place. We report enhanced backpropagation and theta resonance and decreased summation of synaptic inputs in ventral versus dorsal CA1 pyramidal cell distal dendrites. Transcriptional Kv4.2 down-regulation and post-transcriptional hyperpolarization-activated cyclic AMP-gated channel (HCN1/2) up-regulation may underlie these differences, respectively. Our results reveal differential dendritic integrative properties along the dorso-ventral axis, reflecting diverse computational needs.
authors.affiliation: INSERM, U1106, F-13385 Marseille, France; Aix Marseille Université, F-13385 Marseille, France.
authors.forename: Béatrice
authors.initials: B
authors.lastname: Marcelin
authors.affiliation: Cain Foundation Laboratories, Section of Neurology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030.
authors.forename: Joaquin N
authors.initials: JN
authors.lastname: Lugo
authors.affiliation: Cain Foundation Laboratories, Section of Neurology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030.
authors.forename: Amy L
authors.initials: AL
authors.lastname: Brewster
authors.affiliation: Davee Department of Neurology and Clinical Neurosciences, Northwestern University, Chicago, Illinois 60611.
authors.forename: Zhiqiang
authors.initials: Z
authors.lastname: Liu
authors.affiliation: Davee Department of Neurology and Clinical Neurosciences, Northwestern University, Chicago, Illinois 60611.
authors.forename: Alan S
authors.initials: AS
authors.lastname: Lewis
authors.affiliation: Departments of Anatomy/Neurobiology and Pediatrics, University of California, Irvine, California 92697-4475.
authors.forename: Shawn
authors.initials: S
authors.lastname: McClelland
authors.affiliation: Davee Department of Neurology and Clinical Neurosciences, Northwestern University, Chicago, Illinois 60611; Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois 60611.
authors.forename: Dane M
authors.initials: DM
authors.lastname: Chetkovich
authors.affiliation: Departments of Anatomy/Neurobiology and Pediatrics, University of California, Irvine, California 92697-4475.
authors.forename: Tallie Z
authors.initials: TZ
authors.lastname: Baram
authors.affiliation: Cain Foundation Laboratories, Section of Neurology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030; Department of Neurology and Department of Neuroscience, Baylor College of Medicine, Houston, Texas 77030.
authors.forename: Anne E
authors.initials: AE
authors.lastname: Anderson
authors.affiliation: Department of Neuropathology, University of Bonn Medical Center, Sigmund Freud Strasse 25, 53105 Bonn, Germany.
authors.forename: Albert
authors.initials: A
authors.lastname: Becker
authors.affiliation: INSERM, U1106, F-13385 Marseille, France; Aix Marseille Université, F-13385 Marseille, France.
authors.forename: Monique
authors.initials: M
authors.lastname: Esclapez
authors.affiliation: INSERM, U1106, F-13385 Marseille, France; Aix Marseille Université, F-13385 Marseille, France. Electronic address: christophe.bernard@univmed.fr.
authors.forename: Christophe
authors.initials: C
authors.lastname: Bernard
mesh_terms: D000818:Animals; D054815:Cyclic Nucleotide-Gated Cation Channels / Q000096:biosynthesis*; D003712:Dendrites / Q000235:genetics / Q000378:metabolism*; D015536:Down-Regulation / Q000502:physiology*; D064428:Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; D007473:Ion Channels / Q000096:biosynthesis*; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D009928:Organ Specificity; D015221:Potassium Channels / Q000096:biosynthesis*; D017966:Pyramidal Cells / Q000166:cytology / Q000378:metabolism*; D051381:Rats; D051672:Shal Potassium Channels / Q000096:biosynthesis*; D014158:Transcription, Genetic / Q000502:physiology; D015854:Up-Regulation / Q000502:physiology*
chemical_list: D054815:Cyclic Nucleotide-Gated Cation Channels; C578667:Hcn1 protein, rat; D064428:Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; D007473:Ion Channels; D009419:Nerve Tissue Proteins; D015221:Potassium Channels; D051672:Shal Potassium Channels