title: [Survival analysis of short-term prognosis of patients with HBV-related acute-on-chronic liver failure].
abstract: OBJECTIVE
  To investigate the independent risk factors of influencing short-term survival and prognosis of patients with HBV-related acute-on-chronic liver failure (HBV-ACLF).
  
  
  METHODS
  The clinical data of 338 HBV-ACLF patients hospitalized from January 2007 to December 2010 were collected and analyzed by a Cox regression model.
  
  
  RESULTS
  The Cox regression analysis showed that gastrointestinal hemorrhage, hepatorenal syndrome, electrolyte imbalance and hepatic encephalopathy could significantly increase their recent mortality risks. And the values of relative risk (RR) were 2.526, 2.356, 2.068 and 1.896 respectively. Prothrombin activity (Exp(β): 0.821) and opportunity of antiviral therapy (Exp(β) of early stage: 0.526; Exp(β) of medium stage: 0.601) were protective factors of reduced mortality.
  
  
  CONCLUSIONS
  Gastrointestinal hemorrhage, hepatorenal syndrome, electrolyte imbalance, hepatic encephalopathy, prothrombin activity and opportunity of antiviral therapy are independent risk factors of influencing short-term survival and prognosis of HBV-ACLF patients. The combination of MELD score and multivariate analysis is a more scientific method of determining the prognosis of HBV-related ACLF.
authors.affiliation: Beijing Ditan Hospital, Capital Medical University, Beijing, China.
authors.forename: Hui-min
authors.initials: HM
authors.lastname: Liu
authors.forename: Xian-bo
authors.initials: XB
authors.lastname: Wang
authors.forename: Hui
authors.initials: H
authors.lastname: Zeng
authors.forename: Zhi-yun
authors.initials: ZY
authors.lastname: Yang
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D019694:Hepatitis B, Chronic / Q000150:complications / Q000401:mortality* / Q000628:therapy; D006801:Humans; D017114:Liver Failure, Acute / Q000188:drug therapy / Q000401:mortality* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D012044:Regression Analysis; D012189:Retrospective Studies; D016019:Survival Analysis; D055815:Young Adult