title: Newborn screening in Zhejiang, China.
abstract: BACKGROUND
  It has been 11 years since newborn screening started in Zhejiang in 1999. The aim of this study was to analyze and summarize the status of newborn screening in Zhejiang from 1999 to 2009.
  
  
  METHODS
  Blood samples were collected from the heels of newborns 72 hours after birth. We have conducted laboratory tests that the congenital hypothyroidism (CH) and circulating levels of thyroid-stimulating hormone (TSH) was detected. Blood phenylalanine (Phe) was detected for phenylketonuria (PKU). Dissociation-enhanced lanthanide fluorescent immunoassay (DELFIA) was used for detection.
  
  
  RESULTS
  From 1999 to 2009, 3 875 228 newborns were screened and 2309 cases were confirmed as CH and 155 cases were confirmed as PKU. The incidence of CH and PKU were 1:1678 and 1:25 001 respectively.
  
  
  CONCLUSIONS
  In 11 years, the Zhejiang newborn screening center screened more than 3.8 million newborns, and helped more than 2000 CH and PKU patients to obtain early treatment in order to prevent physical disability and mental retardation.
authors.affiliation: Department of Neonatal Screening, Children's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
authors.forename: Riziwanguli
authors.initials: R
authors.lastname: Maitusong
authors.forename: Rukeya
authors.initials: R
authors.lastname: Japaer
authors.forename: Zheng-yan
authors.initials: ZY
authors.lastname: Zhao
authors.forename: Ru-lai
authors.initials: RL
authors.lastname: Yang
authors.forename: Xiao-lei
authors.initials: XL
authors.lastname: Huang
authors.forename: Hua-qing
authors.initials: HQ
authors.lastname: Mao
mesh_terms: D002681:China; D003409:Congenital Hypothyroidism / Q000175:diagnosis; D006801:Humans; D007231:Infant, Newborn; D015997:Neonatal Screening / Q000379:methods*; D010661:Phenylketonurias / Q000175:diagnosis