title: Diagnostic sensitivity of culture and drug resistance patterns in Korean patients with intestinal tuberculosis.
abstract: METHODS
  It is challenging to differentiate between intestinal tuberculosis (ITB) and Crohn's disease in areas where TB is still prevalent. The use of diagnostic tools and verifying the drug resistance patterns of ITB can be helpful for its correct diagnosis.
  
  
  OBJECTIVE
  To determine  the diagnostic sensitivity of a culture assay using colonoscopic biopsy specimens and the drug resistance patterns of Mycobacterium tuberculosis isolated from ITB.
  
  
  METHODS
  Data from 400 patients diagnosed with ITB were retrospectively analysed.
  
  
  RESULTS
  Of the 400 patients, 170  (42.5%) were males; the median age at diagnosis was 40 years. The sensitivity of culture was 44.1% (145/329). Resistance to at least one anti-tuberculosis drug was identified in 13 (17.6%) and multidrug-resistant TB (MDR-TB) was diagnosed in two (2.7%) of the 74 patients for whom drug susceptibility  testing was performed. Including M. tuberculosis isolated from respiratory specimens, the proportion of MDR-TB was 4.4% (5/113); previous anti-tuberculosis treatment was an independent risk factor for MDR-TB (26.7% vs. 1.0%, P < 0.01).
  
  
  CONCLUSIONS
  Culture of colonoscopic  biopsy specimens shows substantial diagnostic sensitivity; the frequency of MDR-TB is higher in previously treated cases than in new cases.
authors.affiliation: Department of Gastroenterology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Korea.
authors.forename: B D
authors.initials: BD
authors.lastname: Ye
authors.forename: S-K
authors.initials: SK
authors.lastname: Yang
authors.forename: D
authors.initials: D
authors.lastname: Kim
authors.forename: T S
authors.initials: TS
authors.lastname: Shim
authors.forename: S-H
authors.initials: SH
authors.lastname: Kim
authors.forename: M-N
authors.initials: MN
authors.lastname: Kim
authors.forename: Y J
authors.initials: YJ
authors.lastname: Lee
authors.forename: H K
authors.initials: HK
authors.lastname: Na
authors.forename: S H
authors.initials: SH
authors.lastname: Park
authors.forename: D-H
authors.initials: DH
authors.lastname: Yang
authors.forename: K J
authors.initials: KJ
authors.lastname: Kim
authors.forename: J-S
authors.initials: JS
authors.lastname: Byeon
authors.forename: S-J
authors.initials: SJ
authors.lastname: Myung
authors.forename: J-H
authors.initials: JH
authors.lastname: Kim
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000995:Antitubercular Agents / Q000627:therapeutic use*; D044466:Asian People; D001706:Biopsy; D016009:Chi-Square Distribution; D003106:Colon / Q000382:microbiology* / Q000473:pathology; D003113:Colonoscopy; D003424:Crohn Disease / Q000175:diagnosis* / Q000208:ethnology / Q000473:pathology; D003937:Diagnosis, Differential; D024901:Drug Resistance, Multiple, Bacterial; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D015999:Multivariate Analysis; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000302:isolation & purification; D011237:Predictive Value of Tests; D056910:Republic of Korea / Q000453:epidemiology; D012189:Retrospective Studies; D018570:Risk Assessment; D012307:Risk Factors; D012680:Sensitivity and Specificity; D016896:Treatment Outcome; D014385:Tuberculosis, Gastrointestinal / Q000175:diagnosis* / Q000188:drug therapy* / Q000208:ethnology / Q000382:microbiology; D018088:Tuberculosis, Multidrug-Resistant / Q000175:diagnosis* / Q000188:drug therapy* / Q000208:ethnology / Q000382:microbiology / Q000473:pathology; D055815:Young Adult
chemical_list: D000995:Antitubercular Agents