title: Perioral rejuvenation with a range of customized hyaluronic acid fillers: efficacy and safety over six months with a specific focus on the lips.
abstract: BACKGROUND
  Injectable fillers are frequently used to restore volume and correct wrinkles in perioral region. However, evidence for perioral indications is scarce.
  
  
  OBJECTIVE
  Assess the efficacy, patient satisfaction, and safety of new range of hyaluronic acid fillers (HA E) in perioral enhancement.
  
  
  METHODS
  This was a multi-center, six-month, open-label study. At baseline, subjects could receive HA E Touch, HA E Classic, HA E Lips and HA E Deep for the treatments of lips, upper lip lines, nasolabial folds and marionette lines, and a touch-up infection was optional three weeks later. Lip Fullness Grading scale (for lips), wrinkle assessments (Lemperle Rating Scales for the remaining indications), adverse events, and local tolerance were evaluated at each visit, and 3-D volume analyses (for nasolabial folds and lips only) at each post-baseline visit. Optimal correction was defined as results obtained three weeks after last injection. A subject satisfaction questionnaire was performed three weeks after last infection.
  
  
  RESULTS
  Overall, HA E Lips was infected for lip enhancement, HA E Thouch and HA E Classic for upper lip lines, and HA E Classic and HA E Deep for both nasolabial folds and marionette lines. After six month, around a 1-grade improvement persisted according to the lip fullness and wrinkle assessment scales. The long duration of effect was confirmed by 3-D analyses, with 62.7-71.4 percent of volumes obtained at week 3 (optimal correction) maintained after six months. The majority of subjects (from 80% for upper lip lines with HA E Classic to 94.8% for nasolabial folds with HA E Deep) were satisfied or very satisfied with their aesthetic outcome. All products were safe and well-tolerated.
  
  
  CONCLUSIONS
  Perioral enhancement with HA E fillers led to sustained effect in terms of lip fullness, wrinkle and 3-D volume assessments, and high subject satisfaction.
authors.affiliation: Centre Medical Saint Jean, Arras, France. hcartier@hotmail.com
authors.forename: Hugues
authors.initials: H
authors.lastname: Cartier
authors.forename: Patrick
authors.initials: P
authors.lastname: Trevidic
authors.forename: Berthold
authors.initials: B
authors.lastname: Rzany
authors.forename: Gerhard
authors.initials: G
authors.lastname: Sattler
authors.forename: Philoppe
authors.initials: P
authors.lastname: Kestemont
authors.forename: Nabil
authors.initials: N
authors.lastname: Kerrouche
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Dhuin
mesh_terms: D003357:Cosmetic Techniques; D005145:Face; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage* / Q000009:adverse effects; D021621:Imaging, Three-Dimensional; D007267:Injections; D008046:Lip; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D012060:Rejuvenation; D015595:Skin Aging; D011795:Surveys and Questionnaires; D013997:Time Factors
chemical_list: D006820:Hyaluronic Acid