title: Immunotherapeutic approaches to improve graft-versus-tumor effect and reduce graft-versus-host disease.
abstract: The therapeutic efficacy of allogeneic stem cell transplantation is mainly based on the alloreactive immune response of the graft against the host. However, the graft-versus-host process can be viewed as a double-edged sword since it is responsible for both the beneficial graft-versus-tumor effect and the deleterious graft-versus-host disease. During the last two decades, intensive research has been focused on the development of novel immunotherapeutic methods aimed to dissociate graft-versus-host disease from graft-versus-tumor effect. A brief description of these efforts is discussed in this review.
authors.affiliation: Department of Bone Marrow Transplantation & Cancer Immunotherapy, Hadassah - Hebrew University Medical Center, Jerusalem, Israel. panagtsirigotis@gmail.com
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Tsirigotis
authors.forename: Reuven
authors.initials: R
authors.lastname: Or
authors.forename: Igor B
authors.initials: IB
authors.lastname: Resnick
authors.forename: Michael-Yechiel
authors.initials: MY
authors.lastname: Shapira
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D006086:Graft vs Host Disease / Q000276:immunology* / Q000517:prevention & control*; D020350:Graft vs Tumor Effect / Q000276:immunology*; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D008212:Lymphocyte Depletion; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology; D014184:Transplantation, Homologous / Q000379:methods