title: Bicyclic guanidine-catalyzed asymmetric Michael additions of 3-benzyl-substituted oxindoles to N-maleimides.
abstract: A bicyclic guanidine-catalyzed Michael addition of 3-benzyl substituted oxindoles to N-maleimides has been developed to produce oxindole derivatives with a quaternary carbon chiral center at the 3-position in excellent yields and enantio- and diastereoselectivities. This is the first incorporation of N-benzylic α-branched succinimides into 3,3-disubstituted oxindoles.
authors.affiliation: Key Laboratory of Natural Medicine and Immuno-Engineering of Henan Province, Henan University, Kaifeng, Henan 475004, People's Republic of China.
authors.forename: Lixin
authors.initials: L
authors.lastname: Li
authors.forename: Wenchao
authors.initials: W
authors.lastname: Chen
authors.forename: Wenguo
authors.initials: W
authors.lastname: Yang
authors.forename: Yuanhang
authors.initials: Y
authors.lastname: Pan
authors.forename: Hongjun
authors.initials: H
authors.lastname: Liu
authors.forename: Choon-Hong
authors.initials: CH
authors.lastname: Tan
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Jiang
mesh_terms: D001643:Bridged Bicyclo Compounds / Q000737:chemistry; D002384:Catalysis; D019791:Guanidine / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D008301:Maleimides / Q000737:chemistry*; D000078183:Oxindoles; D013237:Stereoisomerism; D013388:Succinimides / Q000737:chemistry
chemical_list: D001643:Bridged Bicyclo Compounds; D007211:Indoles; D008301:Maleimides; D000078183:Oxindoles; D013388:Succinimides; C022960:2-oxindole; D019791:Guanidine