title: Investigation of the impact of HLA-DPB1 matching status in 10/10 HLA matched unrelated hematopoietic stem cell transplantation: results of a French single center study.
abstract: The impact of HLA-DPB1 mismatches after unrelated hematopoietic stem cell transplantation (HSCT) remains controversial. We retrospectively analyzed the impact of permissive/non-permissive HLA-DPB1 mismatches on the outcome of 141 patients who underwent 10/10 HLA allelic-matched unrelated HSCT. Each pair was classified according to the 3 (TCE3) and 4-group (TCE4) algorithm based on DPB1 alleles immunogenicity. Outcome analysis revealed that TCE3 and TCE4 non-permissive HLA-DPB1 disparities were not associated with worsened overall survival, relapse risk neither risk of acute GvHD. Overall, this single center retrospective study does not confirm the adverse prognostic of non-permissive HLA-DPB1 mismatches.
authors.affiliation: Service d'Hématologie Clinique, CHU de Nantes, France.
authors.forename: Cyrille
authors.initials: C
authors.lastname: Touzeau
authors.forename: Katia
authors.initials: K
authors.lastname: Gagne
authors.forename: Véronique
authors.initials: V
authors.lastname: Sébille
authors.forename: Patricia
authors.initials: P
authors.lastname: Herry
authors.forename: Patrice
authors.initials: P
authors.lastname: Chevallier
authors.forename: Gilles
authors.initials: G
authors.lastname: Folléa
authors.forename: Anne
authors.initials: A
authors.lastname: Devys
authors.forename: Philippe
authors.initials: P
authors.lastname: Moreau
authors.forename: Mohamad
authors.initials: M
authors.lastname: Mohty
authors.forename: Anne
authors.initials: A
authors.lastname: Cesbron Gautier
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D002648:Child; D002675:Child, Preschool; D004252:DNA Mutational Analysis; D005260:Female; D005602:France; D006086:Graft vs Host Disease / Q000453:epidemiology* / Q000235:genetics / Q000401:mortality; D059868:HLA-DP beta-Chains / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D019337:Hematologic Neoplasms / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation; D006650:Histocompatibility Testing; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D059868:HLA-DP beta-Chains; C071170:HLA-DPB1 antigen