title: Pharmacological and genetic interventions in serotonin (5-HT)(2C) receptors to alter drug abuse and dependence processes.
abstract: The present review provides an overview on serotonin (5-hydroxytryptamine; 5-HT)(2C) receptors and their relationship to drug dependence. We have focused our discussion on the impact of 5-HT(2C) receptors on the effects of different classes of addictive drugs, illustrated by reference to data using pharmacological and genetic tools. The neurochemical mechanism of the interaction between 5-HT(2C) receptors, with focus on the mesocorticolimbic dopaminergic system, and drugs of abuse (using cocaine as an example) is discussed. Finally, we integrate recent nonclinical and clinical research and information with marketed products possessing 5-HT(2C) receptor binding affinities. Accordingly, available nonclinical data and some clinical observations targeting 5-HT(2C) receptors may offer innovative translational strategies for combating drug dependence.This article is part of a Special Issue entitled: Brain Integration.
authors.affiliation: Laboratory of Drug Addiction Pharmacology, Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland. filip@if-pan.krakow.pl
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Filip
authors.forename: Umberto
authors.initials: U
authors.lastname: Spampinato
authors.forename: Andrew C
authors.initials: AC
authors.lastname: McCreary
authors.forename: Edmund
authors.initials: E
authors.lastname: Przegaliński
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D005818:Genetic Engineering; D006801:Humans; D044405:Receptor, Serotonin, 5-HT2C / Q000235:genetics* / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism; D018490:Serotonin Agents / Q000494:pharmacology / Q000627:therapeutic use*; D019966:Substance-Related Disorders / Q000188:drug therapy* / Q000235:genetics* / Q000473:pathology
chemical_list: D044405:Receptor, Serotonin, 5-HT2C; D018490:Serotonin Agents; D012701:Serotonin