title: Recent advances in transition metal-catalyzed enantioselective hydrogenation of unprotected enamines.
abstract: Transition metal-catalyzed enantioselective hydrogenation of enamines is undoubtedly a useful and environment-friendly method for the preparation of optically pure chiral amines and amine derivatives. Over the last few decades, the use of transition metal catalysts containing chiral phosphorus or phosphine-oxazoline ligands attracted much attention for the hydrogenation of unprotected enamines. A number of efficient chiral catalysts have been developed, and some of them have shown high potential for the application in the synthesis of optical chiral amines in both laboratory and industry. This tutorial review focuses on the contributions concerning the transition metal-catalyzed enantioselective hydrogenation of unprotected enamines for the synthesis of chiral amines and amine derivatives.
authors.affiliation: State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China. jhxie@nankai.edu.cn
authors.forename: Jian-Hua
authors.initials: JH
authors.lastname: Xie
authors.forename: Shou-Fei
authors.initials: SF
authors.lastname: Zhu
authors.forename: Qi-Lin
authors.initials: QL
authors.lastname: Zhou
mesh_terms: D000577:Amides / Q000737:chemistry; D001713:Biphenyl Compounds / Q000737:chemistry*; D002384:Catalysis; D056831:Coordination Complexes / Q000737:chemistry; D004952:Esters; D006865:Hydrogenation; D007093:Imidazoles / Q000737:chemistry*; D013237:Stereoisomerism; D028561:Transition Elements / Q000737:chemistry*
chemical_list: D000577:Amides; D001713:Biphenyl Compounds; D056831:Coordination Complexes; D004952:Esters; D007093:Imidazoles; D028561:Transition Elements