title: Do induced hypertension and hypotension affect stroke volume variation in man?
abstract: OBJECTIVE
  To investigate changes in stroke volume variation (SVV) by both induced hypertension (pressor test) and hypotension (depressor test), and also by induced hypotensive anesthesia in patients with good cardiac function.
  
  
  METHODS
  Prospective, controlled clinical study.
  
  
  METHODS
  University hospital.
  
  
  METHODS
  31 ASA physical status 1 and 2 patients, aged 39-62 years, who were scheduled for elective surgery.
  
  
  METHODS
  We conducted three studies: a pressor test study, a depressor test study, and an induced hypotensive anesthesia study. In the pressor test, patients received a bolus of phenylephrine 0.001 mg/kg to increase systolic arterial pressure (SAP) by 30% to 40% compared with baseline. In the depressor test, patients received a bolus of nitroglycerine 0.005 mg/kg to decrease SAP by 30% to 40% compared with baseline. In the induced hypotensive anesthesia test, patients received intravenous (IV) nitroglycerine continuously until mean arterial pressure (MAP) was reduced to 60-70 mmHg.
  
  
  METHODS
  When arterial pressure reached the target pressure for each study type, SVV and other parameters were recorded.
  
  
  RESULTS
  Induced hypertension (pressor test) decreased SVV, while induced hypotension (depressor test) and induced hypotensive anesthesia increased SVV.
  
  
  CONCLUSIONS
  SVV does not misinterpret preload dependency assessment of patients receiving medications to increase or to lower blood pressure.
authors.affiliation: Department of Anesthesiology, Shioya Hospital, International University of Health and Welfare, Tochigi 329-2145, Japan. HFB01245@nifty.com
authors.forename: Zen'ichiro
authors.initials: Z
authors.lastname: Wajima
authors.forename: Toshiya
authors.initials: T
authors.lastname: Shiga
authors.forename: Kazuyuki
authors.initials: K
authors.lastname: Imanaga
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Inoue
mesh_terms: D000328:Adult; D000758:Anesthesia / Q000379:methods*; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006785:Hospitals, University; D006801:Humans; D006973:Hypertension / Q000139:chemically induced*; D007022:Hypotension / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D005996:Nitroglycerin / Q000494:pharmacology; D010656:Phenylephrine / Q000494:pharmacology; D011446:Prospective Studies; D013318:Stroke Volume / Q000187:drug effects*; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014665:Vasodilator Agents / Q000494:pharmacology
chemical_list: D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents; D010656:Phenylephrine; D005996:Nitroglycerin