title: Recent progress on synthesis and activities of allosamidin and its analogues.
abstract: The pseudotrisaccharide allosamidin 1 is a potent family-18 chitinase inhibitor, and it demonstrates biological activities against insects and fungi. Recent development for the synthesis and activities of compound 1 and its analogues was reviewed. Huang et al. described the solid-phase synthesis of allosamidin 1 and its analogues, which were obtained by iterative glycosylation reactions, catalytic hydrogenation, acetylation, and deacetylation, respectively. It indicated that di-N-acetyl-β-chitobiosyl allosamizoline was strongly against insect chitinase from Bombyx mori. Withers and his coworkers have synthesized chitobiose and chitotriose thiazolines, which exhibit chitinase inhibition activity.
authors.affiliation: College of Chemistry, Chongqing Normal University, China. huangdoctor226@163.com
authors.forename: Gangliang
authors.initials: G
authors.lastname: Huang
mesh_terms: D000117:Acetylglucosamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D014312:Trisaccharides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D004791:Enzyme Inhibitors; D014312:Trisaccharides; C054851:allosamidin; D000117:Acetylglucosamine