title: Frozen section-guided wide local excision in the treatment of recurrent scrotal extramammary Paget's disease.
abstract: BACKGROUND
  A wide excision is generally accepted to be the standard modality of treatment for scrotal extramammary Paget's disease (EMPD). The disease has a recurrence rate of about 10% and a second wide excision is still the chief treatment. We investigated the therapeutic methods for recurrent scrotal EMPD.
  
  
  METHODS
  We retrospectively studied the therapeutic methods and prognosis of 26 cases of recurrent EMPD. Seventy-two cases of primary scrotal EMPD served as controls. All of the cases were treated with frozen section-guided wide local excision.
  
  
  RESULTS
  There was no significant difference in the follow-up period of the recurrent cases before recurrence (p=0.3228), local recurrence rate (p=0.449), and total recurrence rate (p=0.100) between the two groups, respectively. There is a favorable trend of worse mortality rate in the recurrence group (p=0.056). The rate of inguinal lymph node metastasis was higher in the group with recurrent disease than in the control group (p=0.017).
  
  
  CONCLUSIONS
  Wide excision of the lesion still appears to be the most effective modality of treatment for recurrent scrotal Paget's disease. Inguinal lymphadenectomy or sentinel lymph node biopsy should be offered to patients with primary lesions.
authors.affiliation: Department of Urology, Zhujiang Hospital, Southern Medical University, Guangzhou, China.
authors.forename: Bingkun
authors.initials: B
authors.lastname: Li
authors.forename: Liping
authors.initials: L
authors.lastname: Li
authors.forename: Xiang
authors.initials: X
authors.lastname: Wang
authors.forename: Ke
authors.initials: K
authors.lastname: Xu
authors.forename: Zujun
authors.initials: Z
authors.lastname: Fang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Ding
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005629:Frozen Sections; D005834:Genital Neoplasms, Male / Q000401:mortality* / Q000601:surgery*; D006801:Humans; D008197:Lymph Node Excision; D008297:Male; D008875:Middle Aged; D010145:Paget Disease, Extramammary / Q000401:mortality / Q000601:surgery*; D012008:Recurrence; D012189:Retrospective Studies; D012611:Scrotum / Q000601:surgery*; D021701:Sentinel Lymph Node Biopsy; D013521:Urologic Surgical Procedures, Male / Q000379:methods