title: One-year results of health-related quality of life among patients undergoing transcatheter aortic valve implantation.
abstract: Recently, it has been demonstrated that transcatheter aortic valve implantation (TAVI) can result in significant improvement in patients' quality of life (QOL) in the short term. At present, however, little is known about the long-term improvements in QOL after TAVI. Thus, our aim was to prospectively assess the 1-year QOL outcome of patients undergoing TAVI. We performed a prospective analysis of 186 patients with symptomatic severe aortic valve stenosis ineligible for conventional aortic valve replacement, who underwent TAVI with either the Medtronic CoreValve or Edwards Sapien device. A total of 106 patients completed the 1-year follow-up protocol. The QOL was measured using the Medical Outcomes Study 36-item short-form health survey questionnaire at baseline and at 3 months and 1 year of follow-up. At 1 year of follow-up, significant improvements in the Medical Outcomes Study 36-item short-form health survey questionnaire scores for physical functioning (baseline 34.6 ± 2.3 vs 1 year of follow-up 45.6 ± 2.7; p <0.001), role physical (20 ± 3.0 vs 34.2 ± 4.4; p <0.001), bodily pain (59.9 ± 3 vs 70 ± 2.7; p <0.01), general health (47.3 ± 1.5 vs 55.2 ± 2.1, p <0.001), vitality (35.9 ± 2 vs 48.5 ± 2; p <0.001), and mental health (62.2 ± 2.2 vs 67.3 ± 1.8; p <0.05) were observed compared to baseline. No significant improvement could be detected for social functioning (75.4 ± 2.5 vs 76.5 ± 2.6; p = 0.79) and role emotional (61.1 ± 4.3 vs 66.5 ± 4.7; p = 0.29). At 1 year of follow-up, the various physical and mental scores were comparable to an age-matched standard population. In conclusion, the present study has demonstrated that TAVI can improve the QOL status of high-surgical risk patients with severe aortic valve stenosis that can be maintained for ≤1 year postproceduraly in survivors. Although the mental subscales improved slightly, the mental component summary score failed to reach statistical significance in our study population.
authors.affiliation: Department of Cardiovascular Surgery, German Heart Center, Munich, Technische Universität München, Munich, Germany. krane@dhm.mhn.de
authors.forename: Markus
authors.initials: M
authors.lastname: Krane
authors.forename: Marcus-André
authors.initials: MA
authors.lastname: Deutsch
authors.forename: Nicolo
authors.initials: N
authors.lastname: Piazza
authors.forename: Teodora
authors.initials: T
authors.lastname: Muhtarova
authors.forename: Yacine
authors.initials: Y
authors.lastname: Elhmidi
authors.forename: Domenico
authors.initials: D
authors.lastname: Mazzitelli
authors.forename: Bernhard
authors.initials: B
authors.lastname: Voss
authors.forename: Hendrik
authors.initials: H
authors.lastname: Ruge
authors.forename: Catalin C
authors.initials: CC
authors.lastname: Badiu
authors.forename: Matthias
authors.initials: M
authors.lastname: Kornek
authors.forename: Sabine
authors.initials: S
authors.lastname: Bleiziffer
authors.forename: Rüdiger
authors.initials: R
authors.lastname: Lange
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001024:Aortic Valve Stenosis / Q000401:mortality / Q000523:psychology / Q000601:surgery*; D019917:Blood Vessel Prosthesis Implantation; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006304:Health Status; D006801:Humans; D008297:Male; D008603:Mental Health; D011446:Prospective Studies; D011788:Quality of Life / Q000523:psychology*; D011795:Surveys and Questionnaires; D016896:Treatment Outcome