title: Orbital gastrointestinal stromal tumor metastasis.
abstract: OBJECTIVE
  To report an uncommon case of orbital gastrointestinal stromal tumor (GIST) metastasis.
  
  
  METHODS
  Observational case report.
  
  
  RESULTS
  A 65-year-old woman with metastatic GIST involving the left orbit with a history of two separate GIST nodules involving the stomach 6 years earlier. Computed tomography (CT) scan demonstrated a well-circumscribed enhancing lesion confined to the anterior orbit. Histopathology analysis of the tumor showed predominantly spindle cells with focal epithelioid forms. It also stained positive for c-KIT (CD117) on immunochemistry, confirming the diagnosis. Additional medical treatment was not required, and the patient was followed up regularly for disease recurrence.
  
  
  CONCLUSIONS
  GISTs typically occur as sporadic solitary tumors. In malignant cases, it usually metastasizes to the liver or other intraabdominal sites. Orbital involvement is extremely rare. This is the first case of metastatic GIST involving the anterior orbit with histopathological and immunochemical confirmation.
authors.affiliation: Sydney Eye Hospital, Ophthalmology, 8 Macquarie Street, Sydney 2000, Australia. daviewoo@gmail.com
authors.forename: David
authors.initials: D
authors.lastname: Woo
authors.forename: James
authors.initials: J
authors.lastname: Leong
authors.forename: Dale
authors.initials: D
authors.lastname: Waring
authors.forename: Alok
authors.initials: A
authors.lastname: Sharma
authors.forename: Peter
authors.initials: P
authors.lastname: Martin
mesh_terms: D000071443:12E7 Antigen; D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D015815:Cell Adhesion Molecules / Q000032:analysis; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology*; D046152:Gastrointestinal Stromal Tumors / Q000737:chemistry / Q000000981:diagnostic imaging / Q000556:secondary*; D006801:Humans; D009918:Orbital Neoplasms / Q000737:chemistry / Q000000981:diagnostic imaging / Q000556:secondary*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000032:analysis; D019009:Proto-Oncogene Proteins c-kit / Q000032:analysis; D014057:Tomography, X-Ray Computed
chemical_list: D000071443:12E7 Antigen; D015703:Antigens, CD; D014408:Biomarkers, Tumor; C061828:CD99 protein, human; D015815:Cell Adhesion Molecules; D019253:Proto-Oncogene Proteins c-bcl-2; D019009:Proto-Oncogene Proteins c-kit