title: Biomimetic synthesis of the antimalarial flindersial alkaloids.
abstract: A biomimetic strategy for the synthesis of the antimalarial flindersial alkaloids is described. Flinderoles A, B, and C, desmethylflinderole C, isoborreverine, and dimethylisoborreverine were all synthesized in three steps from tryptamine. The key step is an acid-promoted dimerization of the natural product borrerine. This approach is thought to mirror the biosynthesis of these compounds.
authors.affiliation: Department of Chemistry, University of Houston, 136 Fleming Building, Houston, Texas 77204-5003, USA.
authors.forename: Ravikrishna
authors.initials: R
authors.lastname: Vallakati
authors.forename: Jeremy A
authors.initials: JA
authors.lastname: May
mesh_terms: D000470:Alkaloids / Q000138:chemical synthesis* / Q000737:chemistry; D000962:Antimalarials / Q000138:chemical synthesis* / Q000737:chemistry; D040761:Biomimetic Materials / Q000138:chemical synthesis* / Q000737:chemistry; D019281:Dimerization; D015394:Molecular Structure
chemical_list: D000470:Alkaloids; D000962:Antimalarials