title: Fibroblasts--a key host cell type in tumor initiation, progression, and metastasis.
abstract: Tumor initiation, growth, invasion, and metastasis occur as a consequence of a complex interplay between the host environment and cancer cells. Fibroblasts are now recognized as a key host cell type involved in host-cancer signaling. This review discusses some recent studies that highlight the roles of fibroblasts in tumor initiation, early progression, invasion, and metastasis. Some clinical studies describing the prognostic significance of fibroblast-derived markers and signatures are also discussed.
authors.affiliation: Department of Oncology-Pathology, Karolinska Institutet, Stockholm, Sweden.
authors.forename: Carina
authors.initials: C
authors.lastname: Strell
authors.forename: Helene
authors.initials: H
authors.lastname: Rundqvist
authors.forename: Arne
authors.initials: A
authors.lastname: Ostman
mesh_terms: D018450:Disease Progression; D005347:Fibroblasts / Q000473:pathology*; D006801:Humans; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D014411:Neoplastic Stem Cells / Q000473:pathology; D015398:Signal Transduction; D059016:Tumor Microenvironment