title: Risk and causes of death in children with a seizure disorder.
abstract: OBJECTIVE
  To describe the frequency and causes of death in children with epilepsy, ascertain the contribution of seizure disorder to cause of death, and compare with rates of sudden unexplained death in children without epilepsy.
  
  
  METHODS
  This study was a retrospective review of clinical and death certificate records. It examined two UK population-based samples of deaths in children with epilepsy from 1 month to 18 years, together comprising the largest reported series of deaths in children with epilepsy (n=265).
  
  
  RESULTS
  In approximately two-thirds, the death was not due to the seizure disorder. Rates of unexplained death were similar in the two samples at 7.3% and 9.7%: all were in children with symptomatic or presumed symptomatic epilepsy. There were no unexplained deaths in the children with idiopathic epilepsy. Four per cent of the deaths were of children experiencing acute symptomatic seizures as part of their final illness. The risk of unexpected, unexplained death in children with idiopathic epilepsy is not more than 65 per 100,000 child-years.
  
  
  CONCLUSIONS
  Epilepsy is associated with an increased risk of death in childhood but this risk is almost entirely confined to those with an associated neurodevelopmental disorder. The risk of unexpected, unexplained death in children with idiopathic epilepsy is extremely small.
authors.affiliation: Institute of Ageing and Health, Newcastle University, Newcastle upon Tyne, UK.  
authors.forename: Victoria
authors.initials: V
authors.lastname: Nesbitt
authors.forename: Martin
authors.initials: M
authors.lastname: Kirkpatrick
authors.forename: Gale
authors.initials: G
authors.lastname: Pearson
authors.forename: Allan
authors.initials: A
authors.lastname: Colver
authors.forename: Rob
authors.initials: R
authors.lastname: Forsyth
mesh_terms: D000293:Adolescent; D002423:Cause of Death; D002648:Child; D002675:Child, Preschool; D003645:Death, Sudden / Q000209:etiology*; D004827:Epilepsy / Q000150:complications* / Q000175:diagnosis / Q000401:mortality*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D018570:Risk Assessment; D012307:Risk Factors; D006113:United Kingdom / Q000453:epidemiology