title: A clinical planning module for adaptive optics SLO imaging.
abstract: OBJECTIVE
  To develop a clinical planning module (CPM) to improve the efficiency of imaging subjects with a steerable wide-field adaptive optics scanning laser ophthalmoscope (AOSLO) and to evaluate the performance of this module by imaging the retina in healthy and diseased eyes.
  
  
  METHODS
  We developed a software-based CPM with two submodules: a navigation module and a montage acquisition module. The navigation module guides the AOSLO to image identified retinal regions from a clinical imaging platform using a matrix-based mapping between the two. The montage acquisition module systematically moves the AOSLO steering mirrors across the retina in predefined patterns. The CPM was calibrated using a model eye and tested on five normal subjects and one patient with a retinal nerve fiber layer defect.
  
  
  RESULTS
  Within the central ±7° from the fixation target, the CPM can direct the AOSLO beam to the desired regions with localization errors of <0.3°. The navigation error increases with eccentricity, and larger errors (up to 0.8°) were evident for regions beyond 7°. The repeatability of CPM navigation was tested on the same locations from two subjects. The localization errors between trials on different days did not differ significantly (p > 0.05). The region with a size of approximately 13° × 10° can be imaged in about 30 min. An approximately 12° × 4.5° montage of the diseased region from a patient was imaged in 18 min.
  
  
  CONCLUSIONS
  We have implemented a clinical planning module to accurately guide the AOSLO imaging beam to desired locations and to quickly acquire high-resolution AOSLO montages. The approach is not only friendly for patients and clinicians but also convenient to relate the imaging data between different imaging platforms.
authors.affiliation: Indiana University, School of Optometry, Bloomington, Indiana 47405, USA.
authors.forename: Gang
authors.initials: G
authors.lastname: Huang
authors.forename: Xiaofeng
authors.initials: X
authors.lastname: Qi
authors.forename: Toco Y P
authors.initials: TY
authors.lastname: Chui
authors.forename: Zhangyi
authors.initials: Z
authors.lastname: Zhong
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Burns
mesh_terms: D004867:Equipment Design; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008297:Male; D019721:Ophthalmoscopes; D009887:Ophthalmoscopy / Q000379:methods*; D055095:Optics and Photonics; D015203:Reproducibility of Results; D012160:Retina / Q000473:pathology*; D012164:Retinal Diseases / Q000175:diagnosis*