title: [Combined usage of diffusion-weighted magnetic resonance imaging and transrectal ultrasound for transrectal prostate biopsy: a preliminary study].
abstract: OBJECTIVE
  To retrospectively analyze the clinical value of diffusion-weighted magnetic resonance imaging (MRDWI) in the detection of prostate cancer in suspected patients.
  
  
  METHODS
  Between January 2009 and December 2010, 141 patients with suspected prostate cancer underwent MRDWI and transrectal ultrasound (TRUS) guided prostate biopsy. They were divided into 4 groups by prostate surface antigen (PSA) < 10 µg/L, 10 µg/L ≤ PSA < 20 µg/L, 20 µg/L ≤ PSA < 50 µg/L and PSA ≥ 50 µg/L. Then the diagnostic accuracy of MRDWI was tested.
  
  
  RESULTS
  The diagnostic rate of patients with PSA < 10 µg/L, 10 µg/L ≤ PSA < 20 µg/L, 20 µg/L ≤ PSA < 50 µg/L and PSA ≥ 50 µg/L were 23.7%, 35.5%, 66.7% and 96.3% respectively. The sensitivity of MRDWI was significantly better than TRUS. In patients with PSA < 10 µg/L, 10 µg/L ≤ PSA < 20 µg/L, 20 µg/L ≤ PSA < 50 µg/L and PSA ≥ 50 µg/L, the patient-based sensitivities were 85.7%, 72.7%, 97.8%, 100.0% respectively; when based by segment of specimen, the sensitivities were 85.5%, 71.9%, 91.5% and 94.4% respectively.
  
  
  CONCLUSIONS
  The sensitivity of MDWI is significantly better than TRUS in the diagnosis of prostate cancer. The combined use of MDWI and TRUS has the benefit of guiding the biopsy of cancer foci in patients with suspected prostate cancer.
authors.affiliation: Department of Urology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
authors.forename: Jin-you
authors.initials: JY
authors.lastname: Wang
authors.forename: Yi-jun
authors.initials: YJ
authors.lastname: Shen
authors.forename: Xiao-hang
authors.initials: XH
authors.lastname: Liu
authors.forename: Hai-liang
authors.initials: HL
authors.lastname: Zhang
authors.forename: Ding-wei
authors.initials: DW
authors.lastname: Ye
authors.forename: Xu-dong
authors.initials: XD
authors.lastname: Yao
authors.forename: Shi-lin
authors.initials: SL
authors.lastname: Zhang
authors.forename: Bo
authors.initials: B
authors.lastname: Dai
authors.forename: Yao
authors.initials: Y
authors.lastname: Zhu
authors.forename: Liang-ping
authors.initials: LP
authors.lastname: Zhou
mesh_terms: D001706:Biopsy / Q000379:methods*; D038524:Diffusion Magnetic Resonance Imaging; D006801:Humans; D008297:Male; D011467:Prostate / Q000000981:diagnostic imaging / Q000473:pathology; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology; D012007:Rectum / Q000000981:diagnostic imaging; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D014463:Ultrasonography