title: Prune-belly syndrome: case series and review of the literature regarding early prenatal diagnosis, epidemiology, genetic factors, treatment, and prognosis.
abstract: Prune-belly syndrome (PBS) is a rare congenital syndrome characterized by deficient abdominal muscles, urinary tract malformation, and in males, cryptorchidism and has an estimated incidence of 1 in 35,000 to 1 in 50,000 live births. The syndrome might be due to severe bladder outlet obstruction or to abdominal muscle deficiency secondary to a migrational defect of the lateral mesoblast between weeks 6 and 7 of pregnancy. The current review of the medical record reports a special focus on epidemiology, genetic factors, early prenatal diagnosis clusters, treatment, and prognosis of PBS.
authors.affiliation: Department of Obstetrics & Gynceology, Guastalla General Hospital, AUSL Reggio Emilia, Italy. Gabriele.Tonni@ausl.re.it
authors.forename: Gabriele
authors.initials: G
authors.lastname: Tonni
authors.forename: Vito
authors.initials: V
authors.lastname: Ida
authors.forename: Ventura
authors.initials: V
authors.lastname: Alessandro
authors.forename: Maria Paola
authors.initials: MP
authors.lastname: Bonasoni
mesh_terms: D000328:Adult; D042241:Early Diagnosis; D005260:Female; D006801:Humans; D008297:Male; D011247:Pregnancy; D011379:Prognosis; D011535:Prune Belly Syndrome / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics*; D016216:Ultrasonography, Prenatal