title: Prevention of mutagenesis: new potential mechanisms of metformin action in neoplastic cells.
abstract: Several experimental and epidemiologic studies have shown that the antidiabetes drug metformin has antitumor properties. The report by Algire and colleagues in this issue of the journal (beginning on page 536) shows for the first time that metformin reduces mutagenesis induced by reactive oxygen species. This report offers new perspectives on metformin in cancer prevention and provides a new mechanism for the reduction of cancer risk in diabetic patients treated with this drug.
authors.affiliation: INSERM U1065, Centre Méditerranéen de Médecine Moléculaire, Team Cellular and molecular physiophathology of obesity and diabetes, and University of Nice Sophia-Antipolis, Faculty of Medicine, Nice, France. bost@unice.fr
authors.forename: Frédéric
authors.initials: F
authors.lastname: Bost
authors.forename: Issam
authors.initials: I
authors.lastname: Ben-Sahra
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Tanti
mesh_terms: D000818:Animals; D004249:DNA Damage; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008297:Male; D008687:Metformin / Q000494:pharmacology*; D017382:Reactive Oxygen Species
chemical_list: D007004:Hypoglycemic Agents; D017382:Reactive Oxygen Species; D008687:Metformin