title: Pharmacokinetics of beta-asarone in rabbit blood, hippocampus, cortex, brain stem, thalamus and cerebellum.
abstract: beta-Asarone has significant pharmacological effects on the central nervous system. As a potential therapeutic agent to manage brain diseases, analysis of the pharmacokinetics of beta-asarone in brain is necessary. We used cardio-perfusion method to exclude the beta-asarone in the brain blood. The brain was divided into five regions: hippocampus, cortex, brain stem, thalamus and cerebellum, and pharmacokinetic differences were investigated. We found that concentration-time profile of beta-asarone in blood, hippocampus, cortex, brain stem and cerebellum could be adequately described by a first-order equation, consistent with a linear two-compartmental model, but a first-order equation with a linear one-compartmental model in thalamus. The half lives of beta-asarone in blood, hippocampus, cortex, brain stem, thalamus and cerebellum were 1.3801, 1.300, 1.937, 7.142, 2.832 and 8.149 h, respectively. Gender differences do not significantly influence plasma pharmacokinetics of beta-asarone.
authors.affiliation: First Affiliated Hospital, Guangzhou University of Chinese Medicine, Guangzhou, China. fangyq2@163.com
authors.forename: Yong-Qi
authors.initials: YQ
authors.lastname: Fang
authors.forename: Chen
authors.initials: C
authors.lastname: Shi
authors.forename: Lin
authors.initials: L
authors.lastname: Liu
authors.forename: Ruo-Ming
authors.initials: RM
authors.lastname: Fang
mesh_terms: D000081248:Allylbenzene Derivatives; D000818:Animals; D000840:Anisoles / Q000097:blood / Q000493:pharmacokinetics*; D001921:Brain / Q000378:metabolism*; D001933:Brain Stem / Q000378:metabolism; D002138:Calibration; D002491:Central Nervous System Agents / Q000097:blood / Q000493:pharmacokinetics*; D002531:Cerebellum / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D005260:Female; D006624:Hippocampus / Q000378:metabolism; D007275:Injections, Intravenous; D008297:Male; D008954:Models, Biological; D011817:Rabbits; D012015:Reference Standards; D015203:Reproducibility of Results; D012997:Solvents; D013788:Thalamus / Q000378:metabolism
chemical_list: D000081248:Allylbenzene Derivatives; D000840:Anisoles; D002491:Central Nervous System Agents; D012997:Solvents; C012195:asarone