title: Urinary neutrophil gelatinase-associated lipocalin is a potential biomarker for renal damage in patients with systemic lupus erythematosus.
abstract: Neutrophil gelatinase-associated lipocalin (NGAL) has been demonstrated to be a novel biomarker in acute and chronic kidney disease. We hypothesized that 24-hour urinary NGAL excretion may be a predictor for renal damage in patients with systemic lupus erythematosus (SLE). Thirty-four SLE patients with renal involvement (SLE-renal group), 8 SLE patients without renal involvement (SLE-nonrenal group), 14 patients with non-SLE autoimmune diseases (disease control or DC group), and 12 healthy volunteers (normal control or NC group) were compared for 24-hour urinary excretion of NGAL and different cytokines. We found that the 24-hour urinary NGAL excretion in the SLE-renal group was higher than that in the SLE-non-renal, DC, and NC groups. However, the excretion of interleukin-10, transforming growth factor-β1, and tumor necrosis factor-α was not different between the SLE-renal and SLE-non-renal groups. Furthermore, NGAL excretion in the SLE-renal group was correlated with serum creatinine levels and creatinine clearance, but not with the SLE Disease Activity Index score. Multivariate logistic regression analysis and receiver operating characteristic curve analysis revealed that 24-hour urinary NGAL excretion is a potential biomarker for renal damage in SLE patients, with higher sensitivity and specificity than anti-dsDNA antibody titers.
authors.affiliation: Department of Internal Medicine, Keelung City Municipal Hospital, Keelung 201, Taiwan.
authors.forename: Chun-Chen
authors.initials: CC
authors.lastname: Yang
authors.forename: Song-Chou
authors.initials: SC
authors.lastname: Hsieh
authors.forename: Ko-Jen
authors.initials: KJ
authors.lastname: Li
authors.forename: Cheng-Han
authors.initials: CH
authors.lastname: Wu
authors.forename: Ming-Chi
authors.initials: MC
authors.lastname: Lu
authors.forename: Chang-Youh
authors.initials: CY
authors.lastname: Tsai
authors.forename: Chia-Li
authors.initials: CL
authors.lastname: Yu
mesh_terms: D000209:Acute-Phase Proteins / Q000652:urine*; D000328:Adult; D015415:Biomarkers / Q000652:urine*; D005260:Female; D006801:Humans; D016753:Interleukin-10 / Q000652:urine; D000071068:Lipocalin-2; D054834:Lipocalins / Q000652:urine*; D016015:Logistic Models; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009393:Nephritis / Q000150:complications / Q000652:urine*; D011507:Proteinuria / Q000150:complications / Q000652:urine*; D011518:Proto-Oncogene Proteins / Q000652:urine*; D012372:ROC Curve; D053773:Transforming Growth Factor beta1 / Q000652:urine; D014409:Tumor Necrosis Factor-alpha / Q000652:urine
chemical_list: D000209:Acute-Phase Proteins; D015415:Biomarkers; C508609:IL10 protein, human; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D011518:Proto-Oncogene Proteins; D053773:Transforming Growth Factor beta1; D014409:Tumor Necrosis Factor-alpha; D016753:Interleukin-10