title: Regulatory role of miR-2909 in cell-mediated immune response.
abstract: Keeping in view the micromanagement of immune response by micro RNAs, the present study was directed to explore the role of miR-2909 in the differentiation and maturation of T-lymphocytes within the population of normal human peripheral blood mononuclear cells maintained in in vitro culture. The results of such a study revealed that miR-2909 had the inherent capacity to significantly increase Treg (CD4+CD25+Foxp3+) cell population and dominant Th1-type cytokine (especially with decrease in IL-4 level and higher levels of INF-β and INF-γ) profile. Based upon these results, we propose that miR-2909 may modulate native immunity in general and help in providing protective immunity against viral infections in particular.
authors.affiliation: Department of Experimental Medicine and Biotechnology, Postgraduate Institute of Medical Education and Research, Chandigarh 160012, India. dkaul_24@hotmail.com
authors.forename: Deepak
authors.initials: D
authors.lastname: Kaul
authors.forename: M
authors.initials: M
authors.lastname: Sasikala
authors.forename: A
authors.initials: A
authors.lastname: Raina
mesh_terms: D017209:Apoptosis / Q000276:immunology; D002454:Cell Differentiation; D002478:Cells, Cultured; D006801:Humans; D035683:MicroRNAs / Q000235:genetics* / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000166:cytology* / Q000276:immunology*; D018417:Th1 Cells / Q000166:cytology / Q000276:immunology
chemical_list: C000589020:MIRN2909 microRNA, human; D035683:MicroRNAs