title: A Review for Mini-Review in Medicinal Chemistry.
abstract: Cantharidin, as a natural toxin, can inhibit multifarious tumor cell lines, especially to hepatocellular carcinoma cells. It is a strong inhibitor of protein phos- phatases type 1 (PP1) and 2A (PP2A). Because of the cytotoxicity, the clinical application is limited. While the analogues, such as norcantharidin(NCTD), cantha- rimide and heterocyclic substituted cantharidin reveal more powerful antitumor activity and less cytotoxicity.
authors.affiliation: Shaoxing university, School of Chemical and Chemical Engineering, Shaoxing 312000, Zhejiang P.R China. wwdlp@126.com.
authors.forename: Liping
authors.initials: L
authors.lastname: Deng
authors.forename: Shenlong
authors.initials: S
authors.lastname: Tang
authors.forename: Qing
authors.initials: Q
authors.lastname: Qian