title: Furosemide-loading vestibular evoked myogenic potential testing can suggest developing bilateral involvement of unilateral Meniere's disease.
abstract: CONCLUSIONS
  Patients with positive results of furosemide-loading vestibular evoked myogenic potential (F-VEMP) testing in the unaffected ears of unilateral Meniere's disease have a high incidence of developing bilateral lesions.
  
  
  OBJECTIVE
  To clarify the meaning of positive results of F-VEMP testing of the unaffected ear of patients with unilateral Meniere's disease.
  
  
  METHODS
  Twenty-five patients with unilateral Meniere's disease were investigated in this study. The positive group consisted of 6 patients with positive results of F-VEMP testing in the contralateral ear and the negative group consisted of 19 patients with negative results. The incidence of contralateral involvement was compared in both groups by the Kaplan-Meier method.
  
  
  RESULTS
  Contralateral involvement was seen in three cases (50%) in the positive group after 2, 12, and 26 months and in three cases (16%) in the negative group after 27, 56, and 78 months. The positive group had a higher incidence of contralateral involvement than the negative group (p = 0.0017, according to a log-rank test).
authors.affiliation: Department of Otolaryngology, Osaka Central Hospital, Osaka, Japan. tseo@osaka-centralhp.jp
authors.forename: Toru
authors.initials: T
authors.lastname: Seo
authors.forename: Naoki
authors.initials: N
authors.lastname: Saka
authors.forename: Masafumi
authors.initials: M
authors.lastname: Sakagami
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D000368:Aged; D001300:Audiometry, Evoked Response; D003937:Diagnosis, Differential; D004232:Diuretics / Q000008:administration & dosage; D004576:Electromyography; D018159:Endolymphatic Hydrops / Q000188:drug therapy / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D005665:Furosemide / Q000008:administration & dosage; D006801:Humans; D015994:Incidence; D007275:Injections, Intravenous; D007564:Japan / Q000453:epidemiology; D008297:Male; D008575:Meniere Disease / Q000175:diagnosis* / Q000453:epidemiology / Q000503:physiopathology; D008875:Middle Aged; D012189:Retrospective Studies; D012720:Severity of Illness Index; D013997:Time Factors; D058585:Vestibular Evoked Myogenic Potentials / Q000187:drug effects*; D014724:Vestibular Function Tests; D014722:Vestibule, Labyrinth / Q000503:physiopathology; D055815:Young Adult
chemical_list: D004232:Diuretics; D005665:Furosemide