title: Carotid endarterectomy plus medical therapy or medical therapy alone for carotid artery stenosis in symptomatic or asymptomatic patients: a meta-analysis.
abstract: OBJECTIVE
  The purpose of this study was to compare carotid endarterectomy (CEA) plus medical therapy (MT) with MT alone for symptomatic and asymptomatic patients suffering from carotid artery stenosis in terms of long-term stroke/death rate.
  
  
  METHODS
  A meta-analysis of parallel randomized, controlled trials (RCTs) (blind or open) published in English.
  
  
  METHODS
  A university-based electronic search.
  
  
  METHODS
  Patients suffering from carotid artery stenosis symptomatic or not.
  
  
  METHODS
  Patients were subjected to CEA plus MT or MT alone.
  
  
  RESULTS
  For asymptomatic patients, 6 RCTs comprising 5,733 patients (CEA = 2,853 and MT = 2,880) were included. CEA did not affect the stroke/death risk for asymptomatic patients (risk ratio [RR] = 0.93; 95% confidence interval [CI], 0.84 to 1.02; I(2) = 0%; p = 0.14). For symptomatic patients, 2 RCTs were included. They had 5,627 patients (CEA = 3,069 and MT = 2,558) of whom 2,295 patients (CEA = 1,213; MT = 1,082) had severe stenosis (North American Symptomatic Carotid Endarterectomy Trial [NASCET] technique ≥50% and European Carotid Surgery Trial technique ≥70%). CEA decreased the stroke/death risk only for patients with severe stenosis (RR = 0.69; 95% CI, 0.59-0.81; p < 0.001 [random effects model]; I(2) = 0% on the odds ratio and 17% on the RR [benefit or harm side]; number needed to treat = 11 [95% CI, 8-17]).
  
  
  CONCLUSIONS
  CEA is helpful for recently symptomatic patients with carotid artery stenosis ≥50% (NASCET technique) but adds no benefit in terms of stroke/death for asymptomatic patients.
authors.affiliation: Department of Anesthesiology, University of Montréal, Montreal, Quebec, Canada. joanne.guay@umontreal.ca
authors.forename: Joanne
authors.initials: J
authors.lastname: Guay
authors.forename: E Andrew
authors.initials: EA
authors.lastname: Ochroch
mesh_terms: D001241:Aspirin / Q000008:administration & dosage; D058070:Asymptomatic Diseases / Q000453:epidemiology / Q000628:therapy*; D016893:Carotid Stenosis / Q000453:epidemiology / Q000628:therapy*; D016894:Endarterectomy, Carotid / Q000379:methods*; D006801:Humans; D008019:Life Style; D016032:Randomized Controlled Trials as Topic / Q000379:methods; D016896:Treatment Outcome
chemical_list: D001241:Aspirin