title: Efficacy of phototherapy devices and outcomes among extremely low birth weight infants: multi-center observational study.
abstract: OBJECTIVE
  Evaluate the efficacy of phototherapy (PT) devices and the outcomes of extremely premature infants treated with those devices.
  
  
  METHODS
  This substudy of the National Institute of Child Health and Human Development Neonatal Research Network PT trial included 1404 infants treated with a single type of PT device during the first 24±12 h of treatment. The absolute (primary outcome) and relative decrease in total serum bilirubin (TSB) and other measures were evaluated. For infants treated with one PT type during the 2-week intervention period (n=1223), adjusted outcomes at discharge and 18 to 22 months corrected age were determined.
  
  
  RESULTS
  In the first 24 h, the adjusted absolute (mean (±s.d.)) and relative (%) decrease in TSB (mg dl(-1)) were: light-emitting diodes (LEDs) -2.2 (±3), -22%; Spotlights -1.7 (±2), -19%; Banks -1.3 (±3), -8%; Blankets -0.8 (±3), -1%; (P<0.0002). Some findings at 18 to 22 months differed between groups.
  
  
  CONCLUSIONS
  LEDs achieved the greatest initial absolute reduction in TSB but were similar to Spots in the other performance measures. Long-term effects of PT devices in extremely premature infants deserve rigorous evaluation.
authors.affiliation: Department of Neonatology, Trinity Mother Frances Health System, Tyler, TX 75703, USA. brenda_2759@msn.com
authors.forename: B H
authors.initials: BH
authors.lastname: Morris
authors.forename: J E
authors.initials: JE
authors.lastname: Tyson
authors.forename: D K
authors.initials: DK
authors.lastname: Stevenson
authors.forename: W
authors.initials: W
authors.lastname: Oh
authors.forename: D L
authors.initials: DL
authors.lastname: Phelps
authors.forename: T M
authors.initials: TM
authors.lastname: O'Shea
authors.forename: G E
authors.initials: GE
authors.lastname: McDavid
authors.forename: K P
authors.initials: KP
authors.lastname: Van Meurs
authors.forename: B R
authors.initials: BR
authors.lastname: Vohr
authors.forename: C
authors.initials: C
authors.lastname: Grisby
authors.forename: Q
authors.initials: Q
authors.lastname: Yao
authors.forename: S
authors.initials: S
authors.lastname: Kandefer
authors.forename: D
authors.initials: D
authors.lastname: Wallace
authors.forename: R D
authors.initials: RD
authors.lastname: Higgins
mesh_terms: D001663:Bilirubin / Q000097:blood*; D005260:Female; D005500:Follow-Up Studies; D017052:Hospital Mortality; D006801:Humans; D052577:Infant, Extremely Low Birth Weight; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D008297:Male; D010789:Phototherapy / Q000009:adverse effects / Q000295:instrumentation* / Q000379:methods; D018570:Risk Assessment; D012720:Severity of Illness Index; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D001663:Bilirubin