title: Abundant blood supply and low P-glycoprotein expression on dynamic 99mTc-MIBI imaging predicted better chemotherapy sensitivity for a breast cancer patient: a case report.
abstract: A patient with a history of breast cancer underwent 3-phase (99m)Tc-methylene diphosphonate (MDP) imaging followed 3 d later by 3-phase (99m)Tc-sestamibi (MIBI) imaging. During the vascular and blood-pool phases, a lymph node over the right clavicle was seen on both the (99m)Tc-MIBI and the (99m)Tc-MDP scans at as early as 30 s and then became hotter. Four months after receiving chemotherapy, the patient achieved a complete response. The lymph node over the right clavicle vanished on ultrasound examination. The similar distribution of the blood-pool phase between the (99m)Tc-MDP and (99m)Tc-MIBI scans indicated that (99m)Tc-MIBI may similarly provide information on vascularization of the lymph node. In addition to indicating vascularization, our (99m)Tc-MIBI protocol may simultaneously provide information on P-glycoprotein expression important for predicting chemotherapy sensitivity. With information on the resistance of a tumor to drugs and the environment in which it dwells, chemotherapy sensitivity might be predicted more precisely.
authors.affiliation: Department of Nuclear Medicine, First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China.
authors.forename: Hongwei
authors.initials: H
authors.lastname: Si
authors.forename: Xianfeng
authors.initials: X
authors.lastname: Li
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism*; D001943:Breast Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000378:metabolism; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008875:Middle Aged; D011877:Radionuclide Imaging; D013669:Technetium Tc 99m Medronate; D017256:Technetium Tc 99m Sestamibi; D016896:Treatment Outcome
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D017256:Technetium Tc 99m Sestamibi; D013669:Technetium Tc 99m Medronate