title: Anemia is associated with mortality following endovascular repair of abdominal aortic aneurysm.
abstract: OBJECTIVE
  The aim of this study was to compare midterm mortality between anemic and nonanemic patients undergoing endovascular repair of abdominal aortic aneurysm and to assess a correlation with markers of inflammation.
  
  
  METHODS
  Anemia was defined as hemoglobin <13 (men) and <12 g/dL (women). The impact of anemia and inflammatory markers on mortality was assessed using Kaplan-Meier curves and Cox regression.
  
  
  RESULTS
  A total of 224 patients (12 females [5.36%]; age: 69.73 ± 8.72 years) were included; 102 (45.53%) were anemic. Median follow-up was 17 months (interquartile range: 7-25 months). Nine patients died (1.79%; 8 anemic vs 1 nonanemic). Survival was lower for patients with anemia (log-rank, P = .01). White blood cell count and C-reactive protein (CRP) differed significantly (P < .001 and P = .01). Anemia and CRP were associated with decreased survival (Cox regression, P = .01, hazard ratio [HR]: 0.35, 95% confidence interval: 0.14-0.84 and P = .002, HR: 1.18, 95% CI: 1.06-1.31).
  
  
  CONCLUSIONS
  Patients with anemia had decreased survival over the midterm; inflammatory markers were higher among this group.
authors.affiliation: Directorate of Research and Development, Russells Hall Hospital, Dudley Group of Hospitals NHS Foundation Trust, Dudley, UK. a_saratzis@yahoo.gr
authors.forename: Athanasios
authors.initials: A
authors.lastname: Saratzis
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Melas
authors.forename: James P
authors.initials: JP
authors.lastname: Hunter
authors.forename: Hannah
authors.initials: H
authors.lastname: Dixon
authors.forename: Peter
authors.initials: P
authors.lastname: Nightingale
authors.forename: Dimitrios
authors.initials: D
authors.lastname: Kiskinis
authors.forename: Nikolaos
authors.initials: N
authors.lastname: Saratzis
authors.forename: George D
authors.initials: GD
authors.lastname: Kitas
mesh_terms: D000368:Aged; D000740:Anemia / Q000097:blood / Q000401:mortality*; D017544:Aortic Aneurysm, Abdominal / Q000097:blood / Q000401:mortality / Q000601:surgery*; D015415:Biomarkers / Q000097:blood; D019917:Blood Vessel Prosthesis Implantation / Q000009:adverse effects / Q000401:mortality*; D002097:C-Reactive Protein / Q000378:metabolism; D015897:Comorbidity; D057510:Endovascular Procedures / Q000009:adverse effects / Q000401:mortality*; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood; D053208:Kaplan-Meier Estimate; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012042:Registries; D018570:Risk Assessment; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome; D006113:United Kingdom / Q000453:epidemiology; D015854:Up-Regulation
chemical_list: D015415:Biomarkers; D018836:Inflammation Mediators; D002097:C-Reactive Protein