title: Benzylic arylation of 2-methyl-5-membered heterocycles using TMP-bases.
abstract: A new general Pd-catalyzed arylation of various 2-methyl-5-membered heterocycles is reported. This novel method requires Li-, Mg-, or Zn-TMP bases and allows selective metalation of the benzylic position. Subsequent Negishi cross-coupling provides the corresponding arylated heterocycles.
authors.affiliation: Department Chemie, Ludwig-Maximilians-Universität München, Butenandtstrasse 5-13, 81377 München, Germany.
authors.forename: Stéphanie
authors.initials: S
authors.lastname: Duez
authors.forename: Andreas K
authors.initials: AK
authors.lastname: Steib
authors.forename: Paul
authors.initials: P
authors.lastname: Knochel
mesh_terms: D002384:Catalysis; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D006842:Hydrocarbons, Brominated / Q000737:chemistry*; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*
chemical_list: D006571:Heterocyclic Compounds; D006842:Hydrocarbons, Brominated; D010165:Palladium