title: Treatment of endometriosis in different ethnic populations: a meta-analysis of two clinical trials.
abstract: Approaches to the treatment of endometriosis vary worldwide, but studies comparing endometriosis medications in different ethnic groups are rare. A systematic literature search identified two studies directly comparing dienogest (DNG) versus gonadotropin-releasing hormone (GnRH) analogues in European and Japanese populations. Meta-analysis of visual analogue scale scores revealed no heterogeneity in response between the trials, indicating equivalent efficacy of DNG and GnRH analogues for endometriosis-related pain across populations. DNG was significantly superior to GnRH analogues for bone mineral density change in both trials, but significant heterogeneity between the studies may indicate ethnic differences in physiology.
authors.affiliation: Global Biostatistics, Bayer HealthCare Pharmaceuticals, Müllerstraße 178, 13353 Berlin, Germany. christoph.gerlinger@bayer.com
authors.forename: Christoph
authors.initials: C
authors.lastname: Gerlinger
authors.forename: Thomas
authors.initials: T
authors.lastname: Faustmann
authors.forename: Jeffrey J
authors.initials: JJ
authors.lastname: Hassall
authors.forename: Christian
authors.initials: C
authors.lastname: Seitz
mesh_terms: D044466:Asian People; D002064:Buserelin / Q000627:therapeutic use*; D004715:Endometriosis / Q000188:drug therapy* / Q000208:ethnology; D005060:Europe; D005260:Female; D006727:Hormone Antagonists / Q000627:therapeutic use*; D006801:Humans; D007564:Japan; D016729:Leuprolide / Q000627:therapeutic use*; D009277:Nandrolone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D016896:Treatment Outcome; D044465:White People
chemical_list: D006727:Hormone Antagonists; C023635:dienogest; D009277:Nandrolone; D016729:Leuprolide; D002064:Buserelin