title: Circulating levels of soluble Fas ligand and left ventricular remodeling after acute myocardial infarction (from the REVE-2 study).
abstract: BACKGROUND
  Apoptosis-related molecules may contribute to left ventricular (LV) remodeling after myocardial infarction (MI). To validate this hypothesis, we evaluated the relation between circulating plasma levels of soluble Fas ligand (sFas-L) and LV remodeling in patients post-MI.
  
  
  RESULTS
  This prospective multicenter study included 246 patients with a first anterior Q-wave MI. Serial echocardiographic studies were performed at hospital discharge and 3 and 12 months after MI; quantitative analysis was performed at a core echocardiography laboratory. Clinical follow-up was performed at 3 years post-MI. Blood samples to measure sFas-L were obtained at 1 month after MI. Median sFas-L level was 50.2 pg/mL. During the 1 year follow-up, LV remodeling was documented by a significant increase in LV volumes. LV end-diastolic and end-systolic volumes at baseline, 3 months, and 12 months after MI did not differ according to sFas-L levels; changes in LV volumes were not associated with sFas-L levels. By multivariate analysis, 2 variables were independently associated with LV remodeling: B-type natriuretic peptide (BNP) (p=0.008) and baseline ejection fraction (p=0.02). sFas-L levels were not associated with cardiovascular death or rehospitalization for heart failure at 3 years; conversely, high levels of BNP were associated with worse clinical outcome.
  
  
  CONCLUSIONS
  Soluble Fas-L levels are not associated with LV remodeling after MI. Further research is needed to identify apoptotic markers that may be associated with outcome post-MI.
authors.affiliation: Centre Hospitalier Régional et Universitaire de Lille, France.
authors.forename: Marie
authors.initials: M
authors.lastname: Fertin
authors.forename: Anne
authors.initials: A
authors.lastname: Bauters
authors.forename: Florence
authors.initials: F
authors.lastname: Pinet
authors.forename: Christophe
authors.initials: C
authors.lastname: Bauters
mesh_terms: D015415:Biomarkers / Q000097:blood; D004452:Echocardiography; D053222:Fas Ligand Protein / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000503:physiopathology*; D020097:Natriuretic Peptide, Brain / Q000097:blood; D011379:Prognosis; D011446:Prospective Studies; D020257:Ventricular Remodeling / Q000502:physiology*
chemical_list: D015415:Biomarkers; D053222:Fas Ligand Protein; D020097:Natriuretic Peptide, Brain