title: Remifentanil impairs sperm motility reversibly in vitro.
abstract: The study is to observe the effects of remifentanil on human sperm motility in vitro. After spermatozoa were washed and resuspended in Ham's F-10 medium, the washed human sperm suspensions were treated in vitro with different concentrations of remifentanil for 30 min. Sperm motility was assessed by computer-assisted sperm analysis at 5, 10, 15, and 30 min. Remifentanil significantly decreased (a + b) grade spermatozoa, between 5 and 10 min at the concentrations ranging from 0.1 to 100 μg L(-1) in a dose-dependent manner and effects no significant difference at 15 and 30 min as compared with control groups. The results suggest that there is indication that this drug has short-term effect on sperm motility.
authors.forename: Bo
authors.initials: B
authors.lastname: Xu
mesh_terms: D000701:Analgesics, Opioid / Q000494:pharmacology; D002478:Cells, Cultured; D006801:Humans; D008297:Male; D010880:Piperidines / Q000494:pharmacology*; D000077208:Remifentanil; D013081:Sperm Motility / Q000187:drug effects*; D013094:Spermatozoa / Q000187:drug effects*
chemical_list: D000701:Analgesics, Opioid; D010880:Piperidines; D000077208:Remifentanil