title: Biology evolves to fight chemistry.
abstract: A human enzyme variant, PON1-G3C9, accidentally catalyzes the hydrolysis of organophosphorus chemical weapons. In this issue of Chemistry & Biology, Goldsmith and coworkers describe a new PON1 variant with improved hydrolysis by several hundred fold; enough that it may protect animals from a toxic dose.
authors.affiliation: University of Minnesota, Department of Biochemistry, Molecular Biology and Biophysics and The Biotechnology Institute, 1479 Gortner Avenue, Saint Paul, MN 55108, USA. rjk@umn.edu
authors.forename: Romas
authors.initials: R
authors.lastname: Kazlauskas