title: Axon degeneration: where the Wlds things are.
abstract: Expression of the Wld(s) protein significantly delays axon degeneration in injuries and diseases, but the mechanism for this protection is unknown. Two recent reports present evidence that axonal mitochondria are required for Wld(S)-mediated axon protection.
authors.affiliation: Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305, USA. jtw@stanford.edu
authors.forename: Jack T
authors.initials: JT
authors.lastname: Wang
authors.forename: Ben A
authors.initials: BA
authors.lastname: Barres
mesh_terms: D000818:Animals; D001369:Axons / Q000473:pathology*; D002118:Calcium / Q000378:metabolism*; D004195:Disease Models, Animal; D029721:Drosophila Proteins / Q000378:metabolism*; D004331:Drosophila melanogaster; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009612:Nicotinamide-Nucleotide Adenylyltransferase / Q000378:metabolism*; D014855:Wallerian Degeneration / Q000235:genetics* / Q000378:metabolism*
chemical_list: D029721:Drosophila Proteins; D009419:Nerve Tissue Proteins; C442580:Wld protein, mouse; D009612:Nicotinamide-Nucleotide Adenylyltransferase; D002118:Calcium