title: [Outcome in patients with acute low-tone sensorineural hearing loss by administration of different doses of glucocorticoids].
abstract: Aimed to compare the outcome in patients with acute low-tone sensorineural hearing loss (ALHL) treated with different doses of glucocorticoids.
  
  
  
  Fifty-four ALHL patients were randomly divided into no-prednisone group (n = ten), low-dose prednisone group (n = 22) and high-dose prednisone group (n = 22). All patients were treated for ten days and followed up for six months from the initial examination.
  
  
  
  The cure rates(complete recovery)were 30.0%, 59.1%, 90.9% respectively and the improved rates (complete recovery and partial recovery) were 40.0%, 86.4%, 95.5% respectively in the three groups of no prednisone group, low-dose prednisone group and high-dose prednisone group. The low-dose prednisone group therapy for ALHL showed significant improved rates than the no prednisone group (P < 0.05). The high-dose prednisone group therapy for ALHL showed significant cure rates than the low-dose prednisone group (P < 0.05).
  
  
  
  High-dose glucocorticoids is more effective than low dose. It is suggested that the etiology of ALHL is related with both an endolymphatic hydrops and an autoimmunological mechanism.
authors.affiliation: Department of Otolaryngology, First Affiliated Hospital of China Medical University, Shenyang 110001, China. huilian613@126.com
authors.forename: Lian
authors.initials: L
authors.lastname: Hui
authors.forename: Gang
authors.initials: G
authors.lastname: Yu
authors.forename: Ning
authors.initials: N
authors.lastname: Yang
authors.forename: Xuejun
authors.initials: X
authors.lastname: Jiang
mesh_terms: D000328:Adult; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use*; D006319:Hearing Loss, Sensorineural / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000008:administration & dosage / Q000627:therapeutic use*; D055815:Young Adult
chemical_list: D005938:Glucocorticoids; D011241:Prednisone