title: The influence of silkworm species on cellular interactions with novel PVA/silk sericin hydrogels.
abstract: Sericin peptides and PVA are chemically modified with methacrylate groups to produce a covalent PVA/sericin hydrogel. Preservation of the sericin bioactivity following methacrylation is confirmed, and PVA/sericin hydrogels are fabricated for both B. mori and A. mylitta sericin. Cell adhesion studies confirm the preservation of sericin bioactivity post incorporation in PVA gels. PVA/A. mylitta gels are observed to facilitate cell adhesion to a significantly greater degree than PVA/B. mori gels. Overall, the incorporation of sericin does not alter the physical properties of the PVA hydrogels but does result in significantly improved cellular interaction, particularly from A. mylitta gels.
authors.affiliation: Graduate School of Biomedical Engineering, University of New South Wales, Sydney 2052, Australia.
authors.forename: Khoon S
authors.initials: KS
authors.lastname: Lim
authors.forename: Joydip
authors.initials: J
authors.lastname: Kundu
authors.forename: April
authors.initials: A
authors.lastname: Reeves
authors.forename: Laura A
authors.initials: LA
authors.lastname: Poole-Warren
authors.forename: Subhas C
authors.initials: SC
authors.lastname: Kundu
authors.forename: Penny J
authors.initials: PJ
authors.lastname: Martens
mesh_terms: D000818:Animals; D040761:Biomimetic Materials / Q000138:chemical synthesis* / Q000494:pharmacology; D012831:Bombyx / Q000737:chemistry; D002448:Cell Adhesion / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects*; D020100:Hydrogels; D009682:Magnetic Resonance Spectroscopy; D008689:Methacrylates / Q000737:chemistry; D051379:Mice; D009036:Moths / Q000737:chemistry; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D047030:Sericins / Q000737:chemistry*; D047011:Silk; D013045:Species Specificity
chemical_list: D020100:Hydrogels; D008689:Methacrylates; D047030:Sericins; D047011:Silk; D011142:Polyvinyl Alcohol