title: Cordifolide A, a sulfur-containing clerodane diterpene glycoside from Tinospora cordifolia.
abstract: Cordifolide A (1), a novel unprecedented sulfur-containing clerodane diterpene glycoside, together with other two new diterpene glycosides, cordifolides B (2) and C (3), and four known analogues, was isolated from a methanol-soluble extract of the stems of Tinospora cordifolia. The structures of the new compounds were determined on the basis of spectroscopic data interpretation, with that of cordifolide A (1) confirmed by a single-crystal X-ray crystallographic analysis. All isolates were evaluated for their in vitro immunomodulatory activity using mouse bone marrow-derived dentritic cells (BMDCs).
authors.affiliation: Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, Department of Pathology, and Department of Chemistry, The Ohio State University, Columbus, Ohio 43210, USA.
authors.forename: Li
authors.initials: L
authors.lastname: Pan
authors.forename: Cesar
authors.initials: C
authors.lastname: Terrazas
authors.forename: Claudio M
authors.initials: CM
authors.lastname: Lezama-Davila
authors.forename: Nirmala
authors.initials: N
authors.lastname: Rege
authors.forename: Judith C
authors.initials: JC
authors.lastname: Gallucci
authors.forename: Abhay R
authors.initials: AR
authors.lastname: Satoskar
authors.forename: A Douglas
authors.initials: AD
authors.lastname: Kinghorn
mesh_terms: D000818:Animals; D018360:Crystallography, X-Ray; D045785:Diterpenes, Clerodane / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007155:Immunologic Factors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D051379:Mice; D008968:Molecular Conformation; D015394:Molecular Structure; D013455:Sulfur / Q000737:chemistry; D031610:Tinospora / Q000737:chemistry*
chemical_list: D045785:Diterpenes, Clerodane; D006027:Glycosides; D007155:Immunologic Factors; C573168:cordifolide A; D013455:Sulfur