title: HPV prevalence and cervical intraepithelial neoplasia among HIV-infected women in Yunnan Province, China: a pilot study.
abstract: OBJECTIVE
  To determine the prevalence of HPV and cervical neoplasia among HIV-infected women in southwestern China.
  
  
  METHODS
  Cervical cytology, HPV detection by Hybrid Capture-2™ assay, and diagnostic colposcopy were followed by cervical biopsy if indicated. Logistic regression analysis was used to analyze associations between HPV co-infection and cervical intraepithelial neoplasia (CIN), and HIV-related clinical and laboratory parameters.
  
  
  RESULTS
  Colposcopic-histopathologically proven CIN2+ lesions were present in 7/83 (8.4%) HIV-infected women. Nearly half (41/83, 43%) were co-infected with carcinogenic HPV genotypes. HPV co-infection was higher in women with colposcopic-histopathologically proven CIN2+ lesions than women with <CIN1 after adjusting for age (OR: 8.3, 95% CI: 0.9, 73.4). Women with CD4+ cell counts less than 350 cells/μL had higher CIN2+ prevalence after adjusting for current ART status and age (adjusted OR: 6.3, 95% CI: 1.1, 36.5).
  
  
  CONCLUSIONS
  HIV/AIDS care and treatment programs should integrate effective cervical cancer prevention services to mitigate the risk of invasive cervical cancer among HIV-infected women in China.
authors.affiliation: Kunming Medical University, Kunming, China.
authors.forename: Hong-Yun
authors.initials: HY
authors.lastname: Zhang
authors.forename: Sarah M
authors.initials: SM
authors.lastname: Tiggelaar
authors.forename: Vikrant V
authors.initials: VV
authors.lastname: Sahasrabuddhe
authors.forename: Jennifer S
authors.initials: JS
authors.lastname: Smith
authors.forename: Cheng-Qin
authors.initials: CQ
authors.lastname: Jiang
authors.forename: Run-Bo
authors.initials: RB
authors.lastname: Mei
authors.forename: Xian-Guo
authors.initials: XG
authors.lastname: Wang
authors.forename: Zu-An
authors.initials: ZA
authors.lastname: Li
authors.forename: You-Lin
authors.initials: YL
authors.lastname: Qiao
mesh_terms: D000328:Adult; D000368:Aged; D002681:China; D060085:Coinfection; D003127:Colposcopy; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D006678:HIV / Q000235:genetics / Q000472:pathogenicity; D015658:HIV Infections / Q000150:complications* / Q000453:epidemiology / Q000821:virology; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae / Q000235:genetics; D030361:Papillomavirus Infections / Q000175:diagnosis* / Q000453:epidemiology* / Q000821:virology; D010865:Pilot Projects; D016133:Polymerase Chain Reaction; D015995:Prevalence; D011379:Prognosis; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000453:epidemiology* / Q000209:etiology; D014626:Vaginal Smears; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000175:diagnosis* / Q000453:epidemiology* / Q000209:etiology
chemical_list: D004279:DNA, Viral