title: Distant metastases from head and neck squamous cell carcinoma. Part III. Treatment.
abstract: Distant metastases from head and neck squamous cell carcinoma (HNSCC), though rare at initial presentation, remain an important manifestation of cancer recurrence and mortality. Although generally considered incurable with a dismal prognosis despite palliative therapy, highly selected patients with distant metastases may have a long term survival benefit from aggressive surgery or radiotherapy. Advances in systemic treatments also may improve patient survival. This article reviews the current state of management of HNSCC patients with distant metastases.
authors.affiliation: Department of Medicine (Oncology), Albert Einstein College of Medicine, Montefiore Medical Center, Bronx, NY, USA.
authors.forename: Missak
authors.initials: M
authors.lastname: Haigentz
authors.forename: Dana M
authors.initials: DM
authors.lastname: Hartl
authors.forename: Carl E
authors.initials: CE
authors.lastname: Silver
authors.forename: Johannes A
authors.initials: JA
authors.lastname: Langendijk
authors.forename: Primož
authors.initials: P
authors.lastname: Strojan
authors.forename: Vinidh
authors.initials: V
authors.lastname: Paleri
authors.forename: Remco
authors.initials: R
authors.lastname: de Bree
authors.forename: Jean-Pascal
authors.initials: JP
authors.lastname: Machiels
authors.forename: Marc
authors.initials: M
authors.lastname: Hamoir
authors.forename: Alessandra
authors.initials: A
authors.lastname: Rinaldo
authors.forename: Daniela
authors.initials: D
authors.lastname: Paccagnella
authors.forename: Ashok R
authors.initials: AR
authors.lastname: Shaha
authors.forename: Robert P
authors.initials: RP
authors.lastname: Takes
authors.forename: Alfio
authors.initials: A
authors.lastname: Ferlito
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D006258:Head and Neck Neoplasms / Q000473:pathology*; D006801:Humans; D009362:Neoplasm Metastasis / Q000628:therapy*; D015996:Survival Rate