title: Increased expression of Toll-like receptors 2 and 4 is associated with poor outcome in intracerebral hemorrhage.
abstract: Inflammatory response in intracerebral hemorrhage (ICH) is associated with poor outcome and could be a consequence of Toll-like receptor (TLR) activation. We investigated the influence of TLR2 and TLR4 expression on the outcome of ICH patients. Expression levels of TLR2 and TLR4 in monocytes at admission were independently associated with poor functional outcome. On the other hand, TLR2 and TLR4 expression at admission in both monocytes and neutrophils was independently associated with residual lesion volume. In conclusion, increased expression of TLR2 and TLR4 is associated with poor functional outcome and greater residual volume in ICH patients.
authors.affiliation: Clinical Neurosciences Research Laboratory, Department of Neurology, Hospital Clínico Universitario, University of Santiago de Compostela, Santiago de Compostela, Spain.
authors.forename: Manuel
authors.initials: M
authors.lastname: Rodríguez-Yáñez
authors.forename: David
authors.initials: D
authors.lastname: Brea
authors.forename: Susana
authors.initials: S
authors.lastname: Arias
authors.forename: Miguel
authors.initials: M
authors.lastname: Blanco
authors.forename: José M
authors.initials: JM
authors.lastname: Pumar
authors.forename: José
authors.initials: J
authors.lastname: Castillo
authors.forename: Tomás
authors.initials: T
authors.lastname: Sobrino
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002543:Cerebral Hemorrhage / Q000378:metabolism* / Q000473:pathology*; D004562:Electrocardiography; D005260:Female; D005786:Gene Expression Regulation / Q000502:physiology; D006801:Humans; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000378:metabolism*; D009504:Neutrophils / Q000378:metabolism*; D011446:Prospective Studies; D012189:Retrospective Studies; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric; D051195:Toll-Like Receptor 2 / Q000378:metabolism*; D051197:Toll-Like Receptor 4 / Q000378:metabolism*; D014057:Tomography, X-Ray Computed
chemical_list: D051195:Toll-Like Receptor 2; D051197:Toll-Like Receptor 4