title: Hypothermia for neonatal hypoxic-ischemic encephalopathy: may an early amplitude-integrated EEG improve the selection of candidates for cooling?
abstract: OBJECTIVE
  To report our experience in the selection of newborns candidate to therapeutic hypothermia.
  
  
  METHODS
  Retrospective study involving 47 newborns suffering from perinatal asphyxia from January 2008 to September 2011.
  
  
  RESULTS
  Thirty-five of 47 newborns admitted to our hospital fulfilled metabolic and neurological criteria for recruitment and were cooled. aEEG was carried out in 26 of them and resulted always abnormal. In three of the 12 newborns with only metabolic criteria, aEEG was moderately abnormal. They were cooled and their outcome (evaluated by General Movements and Griffiths Mental Development Scales for children aged 0-2 years) is good. Three additional newborns who only met the metabolic criterion reached our hospital after the therapeutic window for hypothermia and exhibited seizures; their outcome is poor.
  
  
  CONCLUSIONS
  In our experience, the inclusion of aEEG in the entry criteria would not have precluded newborns with neurological criteria from cooling. On the contrary, without an early aEEG, we would have excluded from hypothermia infants with moderate hypoxic-ischemic encephalopathy without precocious neurological signs who exhibited only the metabolic criterion, but with abnormal aEEG. If further studies will confirm that early aEEG might identify newborns suitable for cooling even in the absence of clinical signs, a revision of the entry criteria should be considered.
authors.affiliation: Neonatal Intensive Care Unit, Medical Surgical Feto-Neonatal Department, Florence, Italy. l.filippi@meyer.it
authors.forename: Luca
authors.initials: L
authors.lastname: Filippi
authors.forename: Serena
authors.initials: S
authors.lastname: Catarzi
authors.forename: Elena
authors.initials: E
authors.lastname: Gozzini
authors.forename: Patrizio
authors.initials: P
authors.lastname: Fiorini
authors.forename: Melania
authors.initials: M
authors.lastname: Falchi
authors.forename: Tiziana
authors.initials: T
authors.lastname: Pisano
authors.forename: Giancarlo
authors.initials: G
authors.lastname: la Marca
authors.forename: Gianpaolo
authors.initials: G
authors.lastname: Donzelli
authors.forename: Renzo
authors.initials: R
authors.lastname: Guerrini
mesh_terms: D001238:Asphyxia Neonatorum / Q000175:diagnosis / Q000628:therapy*; D002675:Child, Preschool; D015331:Cohort Studies; D003080:Cold Temperature; D042241:Early Diagnosis; D004569:Electroencephalography / Q000379:methods; D005260:Female; D006801:Humans; D007036:Hypothermia, Induced / Q000379:methods / Q000706:statistics & numerical data; D020925:Hypoxia-Ischemia, Brain / Q000151:congenital / Q000175:diagnosis / Q000628:therapy*; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D018579:Patient Selection; D012189:Retrospective Studies; D016896:Treatment Outcome