title: Dual-Specificity Phosphatase CDC25A/B Inhibitor Identified from a Focused Library with Nonelectrophilic Core Structure.
abstract: Focused libraries of enamine derivatives with a nonacidic, nonelectrophilic core structure were screened for inhibitors of dual-specificity protein phosphatases, and an o-hydroxybenzyl derivative RE44 (10d) was identified as a selective inhibitor of CDC25A/B. This inhibitor induced cell-cycle arrest of tsFT210 cells at the G2/M phase and inhibited dephosphorylation of the CDC25B substrate CDK1. Unlike most quinone-based inhibitors, 10d does not generate reactive oxygen species.
authors.forename: Ayako
authors.initials: A
authors.lastname: Tsuchiya
authors.forename: Go
authors.initials: G
authors.lastname: Hirai
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Koyama
authors.forename: Kana
authors.initials: K
authors.lastname: Oonuma
authors.forename: Yuko
authors.initials: Y
authors.lastname: Otani
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Osada
authors.forename: Mikiko
authors.initials: M
authors.lastname: Sodeoka