title: Clinical predictors of community-genotype ST72-methicillin-resistant Staphylococcus aureus-SCCmec type IV in patients with community-onset S. aureus infection.
abstract: OBJECTIVE
  Community-genotype methicillin-resistant Staphylococcus aureus (MRSA) clones have emerged in the community worldwide and recently have been spreading into the hospitals. To identify predictors of sequence type 72-MRSA-SCCmec type IV (ST72-MRSA-IV) in patients with community-onset (CO) S. aureus infection, a case-control study was conducted among CO S. aureus infections, including healthcare-associated infections.
  
  
  METHODS
  Eighty-four patients with CO infections caused by ST72-MRSA-IV strains in Korea between 2007 and 2009 were selected as cases. Members of the control group were those with CO methicillin-susceptible S. aureus infections and they were matched by the admission date in a 1 : 1 ratio.
  
  
  RESULTS
  The most common type of infection was skin and soft tissue infection in both groups (48.8% versus 52.4%), followed by pneumonia. Female sex (OR 2.55, 95% CI 1.30-5.04), severe sepsis or septic shock (OR 3.05, 95% CI 1.09-8.55), prior hospitalization within the previous year (OR 2.18, 95% CI 1.10-4.32) and surgical site infection (SSI) (OR 4.63, 95% CI 1.38-15.59) were associated with ST72-MRSA-IV infections in multivariate analyses.
  
  
  CONCLUSIONS
  Female sex, SSI, severe sepsis or septic shock and prior hospitalization within the previous year were predictors of ST72-MRSA-IV among patients with CO S. aureus infection.
authors.affiliation: Division of Infectious Diseases, Samsung Medical Center,  Sungkyunkwan University School of Medicine, Seoul,  Korea.
authors.forename: Eun-Jeong
authors.initials: EJ
authors.lastname: Joo
authors.forename: Doo Ryeon
authors.initials: DR
authors.lastname: Chung
authors.forename: Young Eun
authors.initials: YE
authors.lastname: Ha
authors.forename: So Yeon
authors.initials: SY
authors.lastname: Park
authors.forename: Hyun Ah
authors.initials: HA
authors.lastname: Kim
authors.forename: Min Hee
authors.initials: MH
authors.lastname: Lim
authors.forename: So Hyun
authors.initials: SH
authors.lastname: Kim
authors.forename: Cheol-In
authors.initials: CI
authors.lastname: Kang
authors.forename: Nam Yong
authors.initials: NY
authors.lastname: Lee
authors.forename: Kwan Soo
authors.initials: KS
authors.lastname: Ko
authors.forename: Kyong Ran
authors.initials: KR
authors.lastname: Peck
authors.forename: Jae-Hoon
authors.initials: JH
authors.lastname: Song
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D015510:Clinical Medicine / Q000379:methods; D017714:Community-Acquired Infections / Q000175:diagnosis* / Q000453:epidemiology / Q000382:microbiology* / Q000473:pathology; D003661:Decision Support Techniques; D005260:Female; D005838:Genotype; D006801:Humans; D007223:Infant; D008297:Male; D055624:Methicillin-Resistant Staphylococcus aureus / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D008875:Middle Aged; D058889:Molecular Typing; D056910:Republic of Korea / Q000453:epidemiology; D012307:Risk Factors; D013203:Staphylococcal Infections / Q000175:diagnosis* / Q000453:epidemiology / Q000382:microbiology* / Q000473:pathology; D055815:Young Adult