title: [Relationship between oxidative stress and depression in patients with rheumatoid arthritis].
abstract: OBJECTIVE
  To investigate the relationship between oxidative stress and depression in patients with rheumatoid arthritis (RA).
  
  
  METHODS
  In the study, 129 patients with RA were assessed using the Hamilton depression rating scale (HAMD), Zung self-rating depression scale (SDS), Zung self-rating anxiety scale (SAS), symptom checklist 90 (SCL-90), and other multiple item questionnaires. Oxidative-stress-related parameters in sera and indexes of oxidative damage were monitored during a pretreatment period. The patients were divided into depression (group A, HAMD≥20) and nondepression groups (group B,HAMD<20) based on an HAMD score cutoff of 20. In addition, 20 healthy donors were classified as group C.
  
  
  RESULTS
  A statistically significant increase in SDS score was observed in group A (59.12±10.18) when compared with group B (39.24±5.02) (t=0.42,P < 0.01). A statistically significant increase was observed in SAS score in group A (59.12±10.18) in comparison with group B (39.24±5.02) (t=1.48,P<0.01). Antisuperoxide anion capacity was significantly decreased in group A (393.76±43.35) in comparison with group B (456.98±93.86) and group C (483.51±30.64) (F=3.95, P=0.03), whereas serum malondialdehyde (MDA) levels of group A (13.84±3.35) were higher than those of group B (9.42±3.52) and group C (7.86±3.21)(F=12.01, P=0.01). Pearson correlation analysis revealed that depression was positively correlated with MDA (r=0.58,P<0.05), but negatively with A-ASC (r =-0.30, P<0.05).
  
  
  CONCLUSIONS
  The oxidative damage occurs in patients with rheumatoid arthritis, and lower antioxidant defences exist in depressive patients. The oxidative stress may promote the development of depression.
authors.affiliation: Department of Rheumatology and Immunology, Beijing Shijitan Hospital, Capital Medical University;  Peking University Ninth Hospital, Beijing 100038, China.
authors.forename: Ge
authors.initials: G
authors.lastname: Zhang
authors.forename: Mian-song
authors.initials: MS
authors.lastname: Zhao
authors.forename: Rong-hui
authors.initials: RH
authors.lastname: Xia
authors.forename: Yu-hua
authors.initials: YH
authors.lastname: Wang
authors.forename: Guo-hua
authors.initials: GH
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000503:physiopathology; D003863:Depression / Q000150:complications* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*
chemical_list: D008315:Malondialdehyde