title: A clinicopathological study of the significance of the proportion of choroid morphology in chordoid meningioma.
abstract: Chordoid meningiomas (CM) account for approximately 0.5% to 1.0% of intracranial meningiomas. This tumor has a strong risk of recurrence and aggressive growth (World Health Organization grade II). Histological analysis of CM tumors shows that the tissue is often dominated by chordoid morphology; however, the exact relationship between the percentage of the chordoid component and other clinicopathological features is unknown. We collected 26 surgical specimens from 17 patients who had a histological diagnosis of CM between January 1986 and June 2010. The chordoid elements constituted 30% to 98% of the area of the tumor. In 12 of 17 (70.6%) primary tumors, over 50% of the area displayed the chordoid pattern. Recurrence was noted in nine of these patients and five underwent a second operation. These five patients showed a histopathological progression of aggressive features. The proportion of chordoid elements in each recurrent tumor also increased. Thus, the chordoid proportion in CM is associated with a greater likelihood of recurrence.
authors.affiliation: Department of Pathology, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
authors.forename: Jui-Wei
authors.initials: JW
authors.lastname: Lin
authors.forename: Cheng-Hsien
authors.initials: CH
authors.lastname: Lu
authors.forename: Wei-Che
authors.initials: WC
authors.lastname: Lin
authors.forename: You-Ting
authors.initials: YT
authors.lastname: Wu
authors.forename: Yu-Jie
authors.initials: YJ
authors.lastname: Huang
authors.forename: Fu-Yuan
authors.initials: FY
authors.lastname: Shih
authors.forename: Jih-Tsun
authors.initials: JT
authors.lastname: Ho
authors.forename: Ming-Jung
authors.initials: MJ
authors.lastname: Chuang
mesh_terms: D000328:Adult; D000368:Aged; D002829:Choroid / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D007839:Functional Laterality; D006801:Humans; D017567:Karnofsky Performance Status; D008297:Male; D008577:Meningeal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D008579:Meningioma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D008875:Middle Aged; D012189:Retrospective Studies; D013624:Taiwan; D014057:Tomography, X-Ray Computed