title: Circulating vitamin D correlates with serum antimüllerian hormone levels in late-reproductive-aged women: Women's Interagency HIV Study.
abstract: OBJECTIVE
  To study the correlation between circulating 25-hydroxyvitamin D (25OH-D) levels and serum antimüllerian hormone (AMH) in women enrolled in the Women's Interagency HIV Study.
  
  
  METHODS
  Cross-sectional study.
  
  
  METHODS
  None.
  
  
  METHODS
  All premenopausal women (n = 388) with regular menstrual cycles were included and subdivided into three groups: group 1 with age <35 years (n = 128), group 2 with age 35-39 years (n = 119), and group 3 with age ≥40 years (n = 141).
  
  
  METHODS
  Serum for 25OH-D, AMH, fasting glucose and insulin, and creatinine levels.
  
  
  METHODS
  Correlation between 25OH-D and AMH before and after adjusting for HIV status, body mass index, race, smoking, illicit drug use, glucose and insulin levels, estimated glomerular filtration rate, and geographic site of participation.
  
  
  RESULTS
  After adjusting for all covariates, the regression slope in all participants for total 25OH-D predicting log(10)AMH for 25-year-olds (youngest participant) was -0.001 (SE = 0.008); and for 45-year-olds (oldest participant) the corresponding slope was +0.011 (SE = 0.005). Fasting insulin level was negatively correlated with serum AMH. The regression slope for the correlation between 25OH-D and AMH in group 1 was +0.002 (SE = 0.006); in group 2 was +0.006 (SE = 0.005); and in group 3 was +0.011 (SE = 0.005). There was no association between HIV and AMH.
  
  
  CONCLUSIONS
  A novel relationship is reported between circulating 25OH-D and AMH in women aged ≥40 years, suggesting that 25OH-D deficiency might be associated with lower ovarian reserve in late-reproductive-aged women.
authors.affiliation: Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology and Women's Health, Albert Einstein College of Medicine and Montefiore Medical Center, Bronx, New York 10461, USA. zom00@hotmail.com
authors.forename: Zaher O
authors.initials: ZO
authors.lastname: Merhi
authors.forename: David B
authors.initials: DB
authors.lastname: Seifer
authors.forename: Jeremy
authors.initials: J
authors.lastname: Weedon
authors.forename: Oluwatoyin
authors.initials: O
authors.lastname: Adeyemi
authors.forename: Susan
authors.initials: S
authors.lastname: Holman
authors.forename: Kathryn
authors.initials: K
authors.lastname: Anastos
authors.forename: Elizabeth T
authors.initials: ET
authors.lastname: Golub
authors.forename: Mary
authors.initials: M
authors.lastname: Young
authors.forename: Roksana
authors.initials: R
authors.lastname: Karim
authors.forename: Ruth
authors.initials: R
authors.lastname: Greenblatt
authors.forename: Howard
authors.initials: H
authors.lastname: Minkoff
mesh_terms: D000328:Adult; D000367:Age Factors; D054304:Anti-Mullerian Hormone / Q000097:blood*; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D005260:Female; D015658:HIV Infections / Q000097:blood; D015497:HIV-1 / Q000502:physiology; D006801:Humans; D008875:Middle Aged; D012098:Reproduction / Q000502:physiology*; D014807:Vitamin D / Q000097:blood*
chemical_list: D014807:Vitamin D; D054304:Anti-Mullerian Hormone