title: Early phase clinical trials in pediatric hematology and oncology.
abstract: Pediatric oncology is an unrivaled success story in the recent history of medicine. This success is mostly based on a persistent refinement of evidence based therapeutic concepts. With that regard physicians and their staff are highly experience in the conduct of prospective evidence based trials and are therefore competent partners for the pharmaceutical industry. In times of personalized medicine the individual target population is diminishing and the borders of indications are not more disease based. A situation that requires new concepts from the industry. Therefore children with cancer could benefit early from the current developments as well as the pharmaceutical industry could benefit from the legislative incentives through highly recruiting and well conducted prospective trials. Pivotal is a functional platform of communication in order to maintain a close dialogue between academia and pharmaceutical companies.
authors.affiliation: Pediatrics, University of Regensburg, Franz-Josef- Strauss-Allee 11, Regensburg, Germany. selim.corbacioglu@ukr.de
authors.forename: S
authors.initials: S
authors.lastname: Corbacioglu
mesh_terms: D000046:Academic Medical Centers / Q000191:economics / Q000331:legislation & jurisprudence; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D017321:Clinical Trials, Phase I as Topic / Q000191:economics / Q000331:legislation & jurisprudence / Q000639:trends*; D017322:Clinical Trials, Phase II as Topic / Q000191:economics / Q000331:legislation & jurisprudence / Q000639:trends*; D003299:Cooperative Behavior; D003362:Cost-Benefit Analysis / Q000191:economics / Q000331:legislation & jurisprudence / Q000639:trends; D004345:Drug Industry / Q000191:economics / Q000331:legislation & jurisprudence / Q000639:trends*; D015507:Drugs, Investigational / Q000009:adverse effects / Q000191:economics / Q000627:therapeutic use*; D005060:Europe; D005544:Forecasting; D006297:Health Services Accessibility / Q000191:economics / Q000331:legislation & jurisprudence / Q000639:trends; D006301:Health Services Needs and Demand / Q000191:economics / Q000331:legislation & jurisprudence / Q000639:trends; D006801:Humans; D033183:Interdisciplinary Communication; D007938:Leukemia / Q000188:drug therapy*; D058990:Molecular Targeted Therapy / Q000191:economics / Q000639:trends; D009313:National Health Programs / Q000191:economics / Q000331:legislation & jurisprudence / Q000639:trends; D009369:Neoplasms / Q000188:drug therapy*; D057285:Precision Medicine / Q000191:economics / Q000639:trends*; D011446:Prospective Studies
chemical_list: D000970:Antineoplastic Agents; D015507:Drugs, Investigational