title: [Preparation of curcumin solid dispersion and inclusion complex].
abstract: OBJECTIVE
  To prepare the curcumin solid dispersion and the curcumin inclusion complex, evaluate its stability and the transdermal properties.
  
  
  METHODS
  The samples were prepared with hydrophilic, or water-soluble polymers, by solvent and solvent-melting methods. The optical microscope and the melting point were used to identify the state of the drug existence in it, and UV-Vis spectrophotometer was used to determine the solubility and content of different samples. They were placed under conditions of light, phosphate buffers with different pH values and different metal ions to determine their stability. The lipid/aqueous partition coefficients and the permeation of samples were measured.
  
  
  RESULTS
  The content and solubility of curcumin in the solid dispersion prepared with PVP k-30 as the carrier were larger than those of other solid dispersions, with 81.26% and 337.59 microg/mL, respectively. The oil-water distribution coefficient was 26.04, indicating good penetration properties.
  
  
  CONCLUSIONS
  The solubilty and stability of curcumin can be improved to various degrees. The solubility and oil-water partition coefficient of the curcumin solid dispersion prepared by povidone k-30 as a carrier is the largest.
authors.affiliation: College of Chemistry and Chemical Engineering, Linyi University, Linyi 276005, China. gaozhenshen@lyu.edu.cn
authors.forename: Zhen-Shen
authors.initials: ZS
authors.lastname: Gao
authors.forename: Xiao-Li
authors.initials: XL
authors.lastname: Zhang
authors.forename: Jian-Duo
authors.initials: JD
authors.lastname: Wang
mesh_terms: D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D030024:Curcuma / Q000737:chemistry*; D003474:Curcumin / Q000008:administration & dosage* / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods*; D004355:Drug Stability; D020442:Poloxamer / Q000737:chemistry; D011108:Polymers / Q000737:chemistry; D011205:Povidone / Q000737:chemistry*; D011208:Powders; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D047392:beta-Cyclodextrins / Q000737:chemistry
chemical_list: D004337:Drug Carriers; D011108:Polymers; D011208:Powders; D047392:beta-Cyclodextrins; D020442:Poloxamer; D011205:Povidone; D003474:Curcumin