title: Neural mechanisms of social risk for psychiatric disorders.
abstract: Mental health and social life are intimately inter-related, as demonstrated by the frequent social deficits of psychiatric patients and the increased rate of psychiatric disorders in people exposed to social environmental adversity. Here, we review emerging evidence that combines epidemiology, social psychology and neuroscience to bring neural mechanisms of social risk factors for mental illness into focus. In doing so, we discuss existing evidence on the effects of common genetic risk factors in social neural pathways and outline the need for integrative approaches to identify the converging mechanisms of social environmental and genetic risk in brain.
authors.affiliation: Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. a.meyer-lindenberg@zi-mannheim.de
authors.forename: Andreas
authors.initials: A
authors.lastname: Meyer-Lindenberg
authors.forename: Heike
authors.initials: H
authors.lastname: Tost
mesh_terms: D001921:Brain / Q000473:pathology*; D001931:Brain Mapping; D015220:Calcium Channels / Q000235:genetics; D004644:Emotions / Q000502:physiology; D059647:Gene-Environment Interaction; D006801:Humans; D001523:Mental Disorders / Q000453:epidemiology / Q000235:genetics / Q000473:pathology* / Q000523:psychology*; D018045:Receptors, Oxytocin / Q000235:genetics; D012307:Risk Factors; D012919:Social Behavior; D020864:Calcium Channels, N-Type
chemical_list: D015220:Calcium Channels; D018045:Receptors, Oxytocin; C105656:CACNA1A protein, human; D020864:Calcium Channels, N-Type; C569600:OXTR protein, human