title: Rapid-access, high-throughput synchrotron crystallography for drug discovery.
abstract: Synchrotron X-ray sources provide the highest quality crystallographic data for structure-guided drug design. In general, industrial utilization of such sources has been intermittent and occasionally limited. The Lilly Research Laboratories Collaborative Access Team (LRL-CAT) beamline provides a unique alternative to traditional synchrotron use by pharmaceutical and biotechnology companies. Crystallographic experiments at LRL-CAT and the results therefrom are integrated directly into the drug discovery process, permitting structural data, including screening of fragment libraries, to be routinely and rapidly used on a daily basis as part of pharmaceutical lead discovery and optimization. Here we describe how LRL-CAT acquires and disseminates the results from protein crystallography to maximize their impact on the development of new potential medicines.
authors.affiliation: LRL-CAT, Advanced Photon Source, Argonne National Laboratory, 9700 South Cass Avenue, Building 438, Argonne, IL 60439, USA. swasserman@lilly.com
authors.forename: Stephen R
authors.initials: SR
authors.lastname: Wasserman
authors.forename: John W
authors.initials: JW
authors.lastname: Koss
authors.forename: Sonal T
authors.initials: ST
authors.lastname: Sojitra
authors.forename: Laura L
authors.initials: LL
authors.lastname: Morisco
authors.forename: Stephen K
authors.initials: SK
authors.lastname: Burley
mesh_terms: D018360:Crystallography, X-Ray; D055808:Drug Discovery; D011506:Proteins / Q000737:chemistry*; D017356:Synchrotrons
chemical_list: D011506:Proteins