title: The release rate of curcumin from calcium alginate beads regulated by food emulsifiers.
abstract: Curcumin-loaded alginate beads, which contain different food emulsifiers, have been prepared using CaCl₂ as the cross-linking agent. The controlled release of the curcumin from the beads was investigated at room temperature. For calcium alginate/Span-80/Tween-80 (A/S/T) formulations, almost all of the curcumin loaded in the beads was released into the medium within about 20 h, and the release rates could be regulated by changing the concentration of both Tween-80 and Span-80. However, for the systems of calcium alginate/Q-12A/F-18A (A/Q/F), about 60% of the curcumin loaded in the beads was released at the end of experiments. The studies of scanning electron microscopy indicated that the microstructure of the walls of beads could significantly vary with the concentration or type of emulsifiers. The Fourier transform infrared spectral measurements confirmed that the interactions between calcium alginate and polyglycerol fatty acid esters were stronger than that between calcium alginate and Tween-80/Span-80. The results of swelling studies demonstrated that the initial rates of water uptake for A/Q/F beads were higher than that for A/S/T beads. Moreover, the data of release rates were fitted by an empirical equation, which showed that the release mechanism of curcumin from the alginate gels varied with the composition of emulsifiers for the A/S/T systems. This work provides an important insight into the effect of food emulsifiers on the release rates of the curcumin from calcium alginate beads and will be helpful for the application of the systems in controlled release of other hydrophobic drug.
authors.affiliation: College of Chemistry and Environmental Science, Henan Normal University, 46# East of Construction Road, Xinxiang 453007, People's Republic of China. unsshl@yahoo.com.cn
authors.forename: Shili
authors.initials: S
authors.lastname: Song
authors.forename: Zhen
authors.initials: Z
authors.lastname: Wang
authors.forename: Yuhua
authors.initials: Y
authors.lastname: Qian
authors.forename: Lijie
authors.initials: L
authors.lastname: Zhang
authors.forename: Erfeng
authors.initials: E
authors.lastname: Luo
mesh_terms: D000464:Alginates; D001682:Biological Availability; D003432:Cross-Linking Reagents; D003474:Curcumin / Q000008:administration & dosage*; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D004339:Drug Compounding / Q000379:methods; D045703:Emulsifying Agents / Q000494:pharmacology; D020723:Glucuronic Acid; D006603:Hexuronic Acids; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D010316:Particle Size; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000464:Alginates; D003432:Cross-Linking Reagents; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D045703:Emulsifying Agents; D006603:Hexuronic Acids; D020723:Glucuronic Acid; D003474:Curcumin