title: A highly enantioselective catalytic Strecker reaction of cyclic (Z)-aldimines.
abstract: A range of 3H-indoles and 2H-benzo[b][1,4]thiazines smoothly undergo asymmetric Strecker reaction with ethyl cyanoformate in the presence of a Cinchona alkaloid-based thiourea catalyst at 10 °C to give structurally diverse nitrogen-containing heterocycles in good to excellent yields and with excellent ee.
authors.affiliation: Joint Laboratory of Green Synthetic Chemistry, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China.
authors.forename: You-Dong
authors.initials: YD
authors.lastname: Shao
authors.forename: Shi-Kai
authors.initials: SK
authors.lastname: Tian
mesh_terms: D002384:Catalysis; D002929:Cinchona / Q000737:chemistry; D002930:Cinchona Alkaloids / Q000737:chemistry; D005561:Formates / Q000737:chemistry; D007097:Imines / Q000737:chemistry*; D013237:Stereoisomerism; D013843:Thiazines / Q000737:chemistry; D013890:Thiourea / Q000737:chemistry
chemical_list: D002930:Cinchona Alkaloids; D005561:Formates; D007097:Imines; D013843:Thiazines; C030544:formic acid; D013890:Thiourea