title: Dual role of cyclooxygenase-2 during tissue repair induced by low level laser therapy: an intriguing issue.
abstract: Tissue repair is an excellent example of pathophysiological model for studying the role of cyclooxygenase-2 (COX-2) on eukaryotic cells. It has been established that two COX isoforms are expressed in human tissues: constitutive or induced. COX-1 activity is constitutive, present in nearly all cell types at a constant level; COX-2 activity is normally absent from cells, and when induced, the protein levels increase and decrease in a matter of hours after a single stimulus. Thus, the purpose of this review was to describe the role of COX-2 during tissue repair induced by low level laser therapy (LLLT) in humans and experimental models. COX-2 expression has been implicated in the onset or the exacerbation of inflammation during tissue repair induced by LLLT in a number of studies, Many studies are conducted to investigate the role of COX-2 during tissue repair induced by LLLT using different experimental protocols and dosages. Therefore, this is an area that warrants investigation, since the estimation of COX-2 expression from using such important techniques in therapeutics with respect to tissue repair will be added to those already established in the literature as a way to improve health status and prevention of side effects.
authors.affiliation: Department of Biosciences, Federal University of São Paulo UNIFESP, Santos, SP, Brazil. daribeiro@unifesp.br
authors.forename: Daniel A
authors.initials: DA
authors.lastname: Ribeiro
authors.forename: Ana Paula R
authors.initials: AP
authors.lastname: Paiotti
authors.forename: Carla C
authors.initials: CC
authors.lastname: Medalha
mesh_terms: D000818:Animals; D051545:Cyclooxygenase 1 / Q000378:metabolism; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D018836:Inflammation Mediators / Q000378:metabolism; D028022:Low-Level Light Therapy / Q000009:adverse effects*; D051381:Rats; D012060:Rejuvenation / Q000502:physiology*; D014945:Wound Healing / Q000502:physiology*
chemical_list: D018836:Inflammation Mediators; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2