title: Prognostic Biomarkers and EBV Infection Research in Diffuse Large B-Cell Lymphoma of the Palatine Tonsils.
abstract: Diffuse large B-cell lymphoma represents approximately 30%-40% of all diagnoses of non-Hodgkin's Lymphoma and may represent up to 80% of all lymphomas that arise in the palatine tonsils. Several studies have attempted to correlate clinical, laboratorial, and tissue factors with the prognosis of the lymphomas, such as the International Prognostic Index, the tissue expression of some proteins, and the lymphocyte count at the time of diagnosis, as well as to correlate Epstein-Barr virus (EBV) infection with worse prognoses. Patients with palatine tonsil DLBCL, from Salvador, Bahia, Brazil, were studied in order to identify prognostic factors. Twenty-four patients with DLBCL were studied. The factors that negatively influenced the patients' survival rates were the lymphocyte count at the time of diagnosis <1.000/mm(3) and the Bcl-2 protein expression. There was no CD5 expression in these lymphomas, and neither was there an association with EBV infection.
authors.affiliation: Serviço de Hematologia, Núcleo de Oncologia da Bahia, Avenida Adhemar de Barros 123, Ondina, 40170-110 Salvador, BA, Brazil.
authors.forename: Marinho
authors.initials: M
authors.lastname: Marques
authors.forename: Estela
authors.initials: E
authors.lastname: Luz
authors.forename: Michael
authors.initials: M
authors.lastname: Hummel
authors.forename: Maria das Graças
authors.initials: Md
authors.lastname: Vieira
authors.forename: Regina Célia
authors.initials: RC
authors.lastname: Bahia
authors.forename: Maria Cristina
authors.initials: MC
authors.lastname: Oliveira
authors.forename: Eduardo Martins
authors.initials: EM
authors.lastname: Netto
authors.forename: Ivana
authors.initials: I
authors.lastname: Luz
authors.forename: Iguaracyra
authors.initials: I
authors.lastname: Araújo