title: 1,3,4-oxadiazole: a biologically active scaffold.
abstract: There has been considerable interest in the development of novel compounds with anticonvulsant, antidepressant, analgesic, anti-inflammatory, antiallergic, antipsychotic, antimicrobial, antimycobecterial, antitumour, antiviral and antitubercular activities. 1,3,4-oxadiazoles constitute an important class of compounds for new drug development. Therefore, many researchers have synthesized these compounds as target structures and evaluated their biological activities. These observations led to the development of new 1,3,4-oxadiazole derivatives. This review article describes the various biological activities associated with 1,3,4-oxadiazole ring system and is useful in guiding the researchers across the world working on this moiety and consequently have been instrumental in the advancement of 1,3,4-oxadiazole chemistry.
authors.affiliation: Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi 110 062, India. shabib79@yahoo.co.in
authors.forename: H
authors.initials: H
authors.lastname: Khalilullah
authors.forename: M J
authors.initials: MJ
authors.lastname: Ahsan
authors.forename: Md
authors.initials: M
authors.lastname: Hedaitullah
authors.forename: S
authors.initials: S
authors.lastname: Khan
authors.forename: B
authors.initials: B
authors.lastname: Ahmed
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry / Q000494:pharmacology; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology; D000927:Anticonvulsants / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D055808:Drug Discovery; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000494:pharmacology; D009125:Muscle Relaxants, Central / Q000737:chemistry / Q000494:pharmacology; D010069:Oxadiazoles / Q000737:chemistry* / Q000494:pharmacology*; D010276:Parasympatholytics / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D000927:Anticonvulsants; D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D007004:Hypoglycemic Agents; D009125:Muscle Relaxants, Central; D010069:Oxadiazoles; D010276:Parasympatholytics