title: Clinical characteristics and risk factors of ocular candidiasis.
abstract: Ocular candidiasis is a major complication of Candida bloodstream infection (BSI). This study was performed to reveal the clinical characteristics of ocular candidiasis. Of the 220 patients with Candida BSI, 204 cases received ophthalmology consultations between January 2005 and December 2011 at 2 teaching hospitals. Fifty-four (26.5%) cases had findings consistent with the diagnosis of ocular candidiasis. Of these 54 cases, 43 (79.6%) were diagnosed within 7 days after a positive blood culture. Among ocular candidiasis cases, more cases were due to Candida albicans (P =0.034 odds ratio [OR]; 3.68 95% confidence interval [CI] 1.11-12.2) and had higher β-d-glucan values (P = 0.001 OR; 9.99 95% CI 2.60-21.3). We need to consider fundoscopic examination to be performed within the first 7 days of therapy, especially for those patients who have C. albicans BSIs and higher β-d-glucan values. Additionally, follow-up fundoscopic examination should be considered before stopping therapy for high-risk patients.
authors.affiliation: Department of Infection Control and Prevention, Kyoto University Hospital, Kyoto, Japan. mnagao@kuhp.kyoto-u.ac.jp
authors.forename: Miki
authors.initials: M
authors.lastname: Nagao
authors.forename: Takashi
authors.initials: T
authors.lastname: Saito
authors.forename: Shoichi
authors.initials: S
authors.lastname: Doi
authors.forename: Gou
authors.initials: G
authors.lastname: Hotta
authors.forename: Masaki
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Yasufumi
authors.initials: Y
authors.lastname: Matsumura
authors.forename: Aki
authors.initials: A
authors.lastname: Matsushima
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Ito
authors.forename: Shunji
authors.initials: S
authors.lastname: Takakura
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ichiyama
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D058387:Candidemia / Q000453:epidemiology* / Q000473:pathology*; D002177:Candidiasis / Q000453:epidemiology* / Q000473:pathology*; D003941:Diagnostic Techniques, Ophthalmological; D015821:Eye Infections, Fungal / Q000175:diagnosis / Q000453:epidemiology* / Q000382:microbiology* / Q000473:pathology; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D012307:Risk Factors; D047071:beta-Glucans / Q000378:metabolism
chemical_list: D047071:beta-Glucans