title: T cells activation and interferon-γ/nitric oxide production during Behçet disease: a study in Algerian patients.
abstract: The aim of the current study is to situate CDs expression (CD3+, CD4+, CD8+) and their relationship with IFNγ and NO production in Algerian patients with Behçet disease (n = 34 ). Our results revealed an elevated expression of T cells markers tested in patients in active stage of the disease in relation to IFNγ and NO increase levels. Most interestingly, we noted that CD4+/CD8+ expression correlated with IFNγ and NO production in active stage. In contrast, we observed a decrease of these mediators in inactive stage. Collectively, our results indicate a dependent relation between these parameters and inflammatory response associated with the evolutionary stage of the disease.
authors.forename: Fatmazohra
authors.initials: F
authors.lastname: Djaballah-Ider
authors.forename: Samia
authors.initials: S
authors.lastname: Chaib
authors.forename: Houda
authors.initials: H
authors.lastname: Belguendouz
authors.forename: Djameleddine
authors.initials: D
authors.lastname: Talbi
authors.forename: Chafia
authors.initials: C
authors.lastname: Touil-Boukoffa
mesh_terms: D000328:Adult; D000462:Algeria; D001528:Behcet Syndrome / Q000276:immunology / Q000378:metabolism*; D017252:CD3 Complex / Q000096:biosynthesis / Q000276:immunology; D015704:CD4 Antigens / Q000096:biosynthesis / Q000276:immunology; D016827:CD8 Antigens / Q000096:biosynthesis / Q000276:immunology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000378:metabolism; D007371:Interferon-gamma / Q000096:biosynthesis* / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000096:biosynthesis* / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism*; D055815:Young Adult
chemical_list: D017252:CD3 Complex; D015704:CD4 Antigens; D016827:CD8 Antigens; D009569:Nitric Oxide; D007371:Interferon-gamma