title: Left-to-right shunt reduction with intra-aortic balloon pump in postmyocardial infarction ventricular septal defect.
abstract: This case aims to describe the hemodynamic effects of intra-aortic balloon pump (IABP) in patients with ventricular septal defect (VSD) complicating myocardial infarction (MI). A 79-year-old man with no previous cardiovascular history presented to the emergency department with subacute inferior myocardial infarction associated with mild signs of systemic hypoperfusion. A transthoracic echocardiography revealed a large akinesia of the left ventricular inferior wall with preserved global left ventricular ejection fraction, as well as a large VSD in the midinferior portion of the interventricular septum. Coronary angiography showed an occlusion of the mid portion of a dominant circumflex coronary artery. The invasive hemodynamic evaluation showed a sizable left-to-right shunt (Q(p)/Q(s) = 3.1). Activation of the IABP led to an immediate reduction of the shunt (Q(p)/Q(s) = 2.4 = 22% reduction), an increase in systemic cardiac output (from 2.1 L/min to 2.4 L/min = +12%) and a decrease in the systemic vascular resistances (from 2240 to 1920 dyne-sec/cm(5) = 15% reduction). In patients with post-MI VSD, placement of IABP leads to an immediate reduction in left-to-right shunt and as a consequence to an increase in systemic cardiac output, which may allow hemodynamic stabilization of the patient prior to surgical VSD closure.
authors.affiliation: Cardiology Division, Geneva University Hospitals, Geneva, Switzerland.
authors.forename: Ariane
authors.initials: A
authors.lastname: Testuz
authors.forename: Marco
authors.initials: M
authors.lastname: Roffi
authors.forename: Robert Francis
authors.initials: RF
authors.lastname: Bonvini
mesh_terms: D000368:Aged; D002302:Cardiac Output; D018618:Echocardiography, Doppler, Color; D017809:Fatal Outcome; D006439:Hemodynamics; D006801:Humans; D007423:Intra-Aortic Balloon Pumping; D008297:Male; D009203:Myocardial Infarction / Q000150:complications* / Q000175:diagnosis; D013318:Stroke Volume; D016896:Treatment Outcome; D014655:Vascular Resistance; D016277:Ventricular Function, Left; D018658:Ventricular Septal Rupture / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology / Q000601:surgery / Q000628:therapy*