title: Evidence-based approach to assess passive diffusion and carrier-mediated drug transport.
abstract: Evidence supporting the action of passive diffusion and carrier-mediated (CM) transport in drug bioavailability and disposition is discussed to refute the recently proposed theory that drug transport is CM-only and that new transporters will be discovered that possess transport characteristics ascribed to passive diffusion. Misconceptions and faulty speculations are addressed to provide reliable guidance on choosing appropriate tools for drug design and optimization.
authors.affiliation: Pharmacokinetics, Dynamics and Metabolism, Pfizer Inc., Groton, CT 06340, USA. li.di@pfizer.com
authors.forename: Li
authors.initials: L
authors.lastname: Di
authors.forename: Per
authors.initials: P
authors.lastname: Artursson
authors.forename: Alex
authors.initials: A
authors.lastname: Avdeef
authors.forename: Gerhard F
authors.initials: GF
authors.lastname: Ecker
authors.forename: Bernard
authors.initials: B
authors.lastname: Faller
authors.forename: Holger
authors.initials: H
authors.lastname: Fischer
authors.forename: J Brian
authors.initials: JB
authors.lastname: Houston
authors.forename: Manfred
authors.initials: M
authors.lastname: Kansy
authors.forename: Edward H
authors.initials: EH
authors.lastname: Kerns
authors.forename: Stefanie D
authors.initials: SD
authors.lastname: Krämer
authors.forename: Hans
authors.initials: H
authors.lastname: Lennernäs
authors.forename: Kiyohiko
authors.initials: K
authors.lastname: Sugano
mesh_terms: D000818:Animals; D001692:Biological Transport; D002352:Carrier Proteins / Q000378:metabolism; D002463:Cell Membrane Permeability; D004058:Diffusion; D004337:Drug Carriers; D006801:Humans; D008567:Membranes, Artificial; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000378:metabolism*; D010599:Pharmacokinetics
chemical_list: D002352:Carrier Proteins; D004337:Drug Carriers; D008567:Membranes, Artificial; D004364:Pharmaceutical Preparations