title: A hierarchy of computationally derived surgical and patient influences on metal on metal press-fit acetabular cup failure.
abstract: The impact of anatomical variation and surgical error on excessive wear and loosening of the acetabular component of large diameter metal-on-metal hip arthroplasties was measured using a multi-factorial analysis through 112 different simulations. Each surgical scenario was subject to eight different daily loading activities using finite element analysis. Excessive wear appears to be predominantly dependent on cup orientation, with inclination error having a higher influence than version error, according to the study findings. Acetabular cup loosening, as inferred from initial implant stability, appears to depend predominantly on factors concerning the area of cup-bone contact, specifically the level of cup seating achieved and the individual patient's anatomy. The extent of press fit obtained at time of surgery did not appear to influence either mechanism of failure in this study.
authors.affiliation: Structural Biomechanics, Department of Civil and Environmental Engineering, Imperial College London, Skempton Building, South Kensington Campus, London SW7 2AZ, UK. susannah.clarke@imperial.ac.uk
authors.forename: S G
authors.initials: SG
authors.lastname: Clarke
authors.forename: A T M
authors.initials: AT
authors.lastname: Phillips
authors.forename: A M J
authors.initials: AM
authors.lastname: Bull
authors.forename: J P
authors.initials: JP
authors.lastname: Cobb
mesh_terms: D000077:Acetabulum / Q000601:surgery*; D000328:Adult; D000368:Aged; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D003198:Computer Simulation; D005260:Female; D020342:Finite Element Analysis; D006801:Humans; D008297:Male; D008422:Materials Testing; D019300:Medical Errors; D008670:Metals; D008875:Middle Aged; D011475:Prosthesis Failure
chemical_list: D008670:Metals