title: Electrically silent Kv subunits: their molecular and functional characteristics.
abstract: Electrically silent voltage-gated potassium (KvS) α-subunits do not form homotetramers but heterotetramerize with Kv2 subunits, generating functional Kv2/KvS channel complexes in which the KvS subunits modulate the Kv2 current. This poses intriguing questions into the molecular mechanisms by which these KvS subunits cannot form functional homotetramers, why they only interact with Kv2 subunits, and how they modulate the Kv2 current.
authors.affiliation: Department of Biomedical Sciences, Laboratory for Molecular Biophysics, Physiology and Pharmacology, University of Antwerp, Antwerpen, Belgium.
authors.forename: Elke
authors.initials: E
authors.lastname: Bocksteins
authors.forename: Dirk J
authors.initials: DJ
authors.lastname: Snyders
mesh_terms: D000818:Animals; D006801:Humans; D015640:Ion Channel Gating; D024642:Potassium Channels, Voltage-Gated / Q000737:chemistry / Q000378:metabolism*; D055503:Protein Multimerization; D021122:Protein Subunits / Q000737:chemistry / Q000378:metabolism
chemical_list: D024642:Potassium Channels, Voltage-Gated; D021122:Protein Subunits