title: Magnetic resonance image-guided biopsies with a high detection rate of prostate cancer.
abstract: OBJECTIVE
  To explore the potential of transrectal magnetic resonance image- (MRI-) guided biopsies of the prostate in a patient cohort with prior negative ultrasound guided biopsies.
  
  
  METHODS
  Ninety-six men with suspected prostate cancer underwent MRI-guided prostate biopsies under real-time imaging control in supine position.
  
  
  RESULTS
  Adenocarcinoma of the prostate was detected in 39 of 96 patients. For individual core biopsies, MRI yielded a sensitivity of 93.0% and a specificity of 94.4%. When stratifying patients according to the free-to-total prostate-specific antigen (PSA) ratio, the prostate cancer discovery rate was significantly higher in the group with ratios less than 0.15 (57.1%).
  
  
  CONCLUSIONS
  MRI-guided biopsy of the prostate is a diagnostic option for patients with suspected prostate cancer and a history of repeatedly negative transrectal ultrasound-guided biopsies. Combined with the free-to-total PSA ratio, it is a highly effective method for detecting prostate cancer.
authors.affiliation: Department of Urology, University Hospital Erlangen, Friedrich-Alexander University of Erlangen-Nuremberg, Krankenhausstrasse 12, 91054 Erlangen, Germany. dirk.engehausen@uk-erlangen.de
authors.forename: Dirk G
authors.initials: DG
authors.lastname: Engehausen
authors.forename: Karl
authors.initials: K
authors.lastname: Engelhard
authors.forename: Siegfried A
authors.initials: SA
authors.lastname: Schwab
authors.forename: Michael
authors.initials: M
authors.lastname: Uder
authors.forename: Sven
authors.initials: S
authors.lastname: Wach
authors.forename: Bernd
authors.initials: B
authors.lastname: Wullich
authors.forename: F Steffen
authors.initials: FS
authors.lastname: Krause
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000473:pathology; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000473:pathology