title: [Quadratic regression-orthogonal design optimization ethanol extraction craft of baicalin].
abstract: OBJECTIVE
  To optimize the extraction process of baicalin using the quadratic regression-orthogonal design.
  
  
  METHODS
  The influential factors were ethanol doses, ethanol concentration and extract time. Used the high level statistical method to design experiment parameter and forecast analysis results.
  
  
  RESULTS
  The optimization conditions of extraction was 64% ethanol, 115 min for extract time,volume of use 11. 6 times and it's extraction rate was 85.21%.
  
  
  CONCLUSIONS
  It shows that the optimum model is simple,highly precision and highly predictive.
authors.affiliation: The 155th Central Hospital of PLA, Kaifeng 475003, China. 155sl@163.com
authors.forename: Lei
authors.initials: L
authors.lastname: Shi
authors.forename: Zhen-Wei
authors.initials: ZW
authors.lastname: Zhang
mesh_terms: D002851:Chromatography, High Pressure Liquid; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification; D000431:Ethanol / Q000008:administration & dosage / Q000737:chemistry; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification*; D008962:Models, Theoretical; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D031364:Scutellaria baicalensis / Q000737:chemistry*; D013678:Technology, Pharmaceutical / Q000379:methods*; D013997:Time Factors
chemical_list: D004365:Drugs, Chinese Herbal; D005419:Flavonoids; C038044:baicalin; D000431:Ethanol