title: Effect of zinc supplementation on lipid peroxidation and lactate levels in rats with diabetes induced by streptozotocin and subjected to acute swimming exercise.
abstract: OBJECTIVE
  The present study aims to explore the effect of zinc supplementation on lipid peroxidation and lactate levels in rats having diabetes induced by streptozotocin and subjected to acute swimming exercise.
  
  
  METHODS
  A total of 80 adult male rats of Sprague-Dawley type were equally allocated to 8 groups: Group 1, general control. Group 2, zinc-supplemented group. Group 3, zinc-supplemented, diabetic group. Group 4, swimming control group. Group 5, zinc-supplemented swimming group. Group 6, zinc-supplemented diabetic swimming group. Group 7, diabetic swimming group. Group 8, diabetic group. At the end of the 4-week study, blood samples were collected to determine MDA, GSH, GPx, SOD, lactate and zinc levels.
  
  
  RESULTS
  The highest MDA values were found in group 7 and 8 (p<0.001). GSH values in groups 5 and 6 were higher (p<0.001). The highest GPx values were established in groups 2, 5 and 6 (p<0.001). SOD values were the highest in groups 5 and 6 (p<0.001) and lowest in groups 2, 3 and 8 (p<0.001). The highest plasma lactate levels were found in group 7 (p<0.001). The highest zinc levels were obtained in groups 1, 2 and 5 (p<0.001), and the lowest zinc levels were found in groups 7 and 8 (p<0.001).
  
  
  CONCLUSIONS
  Results of the study reveal that zinc supplementation prevents the increase of free radical formation, suppression of antioxidant activity and muscle exhaustion, all of which result from diabetes and acute exercise. Zinc supplementation may contribute to health performance in diabetes and acute exercise (Tab. 2, Fig. 1 Ref. 47). Full Text in PDF www.elis.sk.
authors.affiliation: Selcuk University of Physical Education and Sports, Konya, Turkey. murselbicer@yahoo.com
authors.forename: M
authors.initials: M
authors.lastname: Bicer
authors.forename: M
authors.initials: M
authors.lastname: Gunay
authors.forename: A K
authors.initials: AK
authors.lastname: Baltaci
authors.forename: K
authors.initials: K
authors.lastname: Uney
authors.forename: R
authors.initials: R
authors.lastname: Mogulkoc
authors.forename: M
authors.initials: M
authors.lastname: Akil
mesh_terms: D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D019344:Lactic Acid / Q000097:blood*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D005082:Physical Exertion / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013550:Swimming; D015032:Zinc / Q000494:pharmacology*
chemical_list: D019344:Lactic Acid; D015032:Zinc