title: PKCη is a novel prognostic marker in non-small cell lung cancer.
abstract: BACKGROUND
  Novel biomarkers which may serve as therapeutic targets are essential for lung cancer treatment. Here we investigated the prognostic significance of protein kinase Cη (PKCη), a cell cycle regulator involved in tumorigenesis and chemotherapy resistance, in patients diagnosed with non-small cell lung cancer (NSCLC).
  
  
  METHODS
  Sixty-three chemotherapy-naïve patients were examined for PKCη by immunohistochemistry and divided into PKCη H-Score tertiles (low, intermediate and high). Time until event (relapse or mortality) within one year was determined using Cochran-Armitage test and Cox proportional hazards regression model.
  
  
  RESULTS
  The distribution of patients according to clinical stage 1-4 was: 27%, 5%, 26% and 42%, respectively. PKCη overexpression was associated with advanced stage (p=0.03) and the risk for an event (p=0.045). Patients of the lowest tertile were less likely to experience an event.
  
  
  CONCLUSIONS
  PKCη is a novel prognostic marker in NSCLC that may predict poor prognosis. The use of PKCη-specific inhibitors in NSCLC may prove valuable.
authors.affiliation: The Shraga Segal Department of Microbiology and Immunology, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel.
authors.forename: Ella
authors.initials: E
authors.lastname: Krasnitsky
authors.forename: Yael
authors.initials: Y
authors.lastname: Baumfeld
authors.forename: Janna
authors.initials: J
authors.lastname: Freedman
authors.forename: Netta
authors.initials: N
authors.lastname: Sion-Vardy
authors.forename: Samuel
authors.initials: S
authors.lastname: Ariad
authors.forename: Victor
authors.initials: V
authors.lastname: Novack
authors.forename: Etta
authors.initials: E
authors.lastname: Livneh
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D002289:Carcinoma, Non-Small-Cell Lung / Q000097:blood*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011493:Protein Kinase C / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; C081975:protein kinase C eta; D011493:Protein Kinase C