title: Adiponectin profile in Asian patients undergoing coronary revascularization and its association with plaque vulnerability: IDEAS-ADIPO study.
abstract: Despite potent insulin-sensitizing, anti-inflammatory, and antiatherogenic effects in animal studies, the relationship between serum adiponectin level and coronary artery disease in patients remains unclear. We determined the adiponectin profile in a cohort of multiethnic Asian patients with coronary artery disease, and the association between serum adiponectin level and culprit lesion necrotic core (NC) content. Ninety-four Asian patients (BMI, 25.3 ± 3.7 kg/m(2)) undergoing percutaneous coronary intervention were recruited. The serum adiponectin level was measured (n = 94), and the baseline virtual histology intravascular ultrasound examination was analyzed (n = 88). The median level of adiponectin was 3.7 µg/ml (interquartile range, 2.8-4.5 µg/ml). The serum adiponectin level was below 10 µg/ml in 90 patients (95.7%) and below 6 µg/ml in 80 patients (85.1%). There was a significant association between ethnicity and serum adiponectin level (P = 0.048). The median adiponectin level was highest among the Chinese, followed by the Malay and the Indians. Serum adiponectin levels were positively associated with culprit lesion NC content. A 1-µg/ml increase in log adiponectin was associated with a 3.04% (95% confidence interval: 0.33-5.44) increase in culprit lesion NC content. This association remains significant after adjusting for age, sex, ethnicity, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and procedural indication. We found a low serum level of adiponectin in Asian patients and a significant ethnic effect on serum adiponectin level. Increased serum adiponectin levels were independently associated with increased culprit lesion NC burden, suggesting a role for adiponectin in modulating coronary plaque vulnerability.
authors.affiliation: Department of Medicine, National University of Singapore, Singapore. mdclchr@nus.edu.sg)
authors.forename: Chi-Hang
authors.initials: CH
authors.lastname: Lee
authors.forename: William K T
authors.initials: WK
authors.lastname: Hau
authors.forename: Bee-Choo
authors.initials: BC
authors.lastname: Tai
authors.forename: Mark Y
authors.initials: MY
authors.lastname: Chan
authors.forename: Betty
authors.initials: B
authors.lastname: Saw
authors.forename: Qian-Hui
authors.initials: QH
authors.lastname: Phua
authors.forename: Adrian F
authors.initials: AF
authors.lastname: Low
authors.forename: Tiong-Cheng
authors.initials: TC
authors.lastname: Yeo
authors.forename: A Mark
authors.initials: AM
authors.lastname: Richards
authors.forename: Huay-Cheem
authors.initials: HC
authors.lastname: Tan
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D044466:Asian People; D015992:Body Mass Index; D003324:Coronary Artery Disease / Q000097:blood* / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000601:surgery; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D062645:Percutaneous Coronary Intervention; D058226:Plaque, Atherosclerotic / Q000097:blood* / Q000000981:diagnostic imaging / Q000453:epidemiology; D012846:Singapore / Q000453:epidemiology; D014463:Ultrasonography
chemical_list: D052242:Adiponectin