title: Chromosomal Instability: Mad2 beyond the spindle checkpoint.
abstract: What specific defects can cause chromosomal instability in cancer cells? Overexpression of the mitotic checkpoint protein Mad2 triggers chromosome missegregation but, surprisingly, Mad2 exerts this effect through a previously unknown effect on microtubule dynamics.
authors.affiliation: Graduate Group in Biochemistry and Molecular Biophysics, University of Pennsylvania, Philadelphia, PA 19104, USA.
authors.forename: Edward R
authors.initials: ER
authors.lastname: Ballister
authors.forename: Michael A
authors.initials: MA
authors.lastname: Lampson
mesh_terms: D002135:Calcium-Binding Proteins / Q000378:metabolism*; D018797:Cell Cycle Proteins / Q000378:metabolism*; D020090:Chromosome Segregation; D018386:Kinetochores / Q000378:metabolism*; D064246:Mad2 Proteins; D008870:Microtubules / Q000378:metabolism*; D012097:Repressor Proteins / Q000378:metabolism*
chemical_list: D002135:Calcium-Binding Proteins; D018797:Cell Cycle Proteins; C577697:MAD2L1 protein, human; D064246:Mad2 Proteins; D012097:Repressor Proteins