title: Effect of topical anesthesia on evaluation of corneal sensitivity and intraocular pressure in rats and dogs.
abstract: OBJECTIVE
  To determine the effect of 0.5% proparacaine in tonometry by evaluating corneal touch threshold (CTT) and intraocular pressure (IOP).
  
  
  METHODS
  Nine rats (18 eyes, Sprague-Dawley) and 10 dogs (20 eyes, Beagle)
  
  
  METHODS
  The IOP and CTT were measured in each eye before and after topical anesthesia with 0.5% proparacaine. The IOP was evaluated using Tonopen for dogs and Tonolab for rats. The corneal sensitivity was evaluated by CTT through a Cochet-Bonnet aesthesiometer.
  
  
  RESULTS
  The mean IOP was not significantly changed in rats or dogs before and after topical anesthesia. However, after application of proparacaine, CTT was significantly increased in both animal groups compared with that before application of proparacaine.
  
  
  CONCLUSIONS
  From this study, topical anesthesia was found to significantly lower the corneal sensitivity but have little effect on IOP measurements. In ophthalmologic examination, topical anesthesia can be used to reduce corneal sensation without an effect on IOP.
authors.affiliation: College of Veterinary Medicine, Chonbuk National University, Jeonju, South Korea.
authors.forename: Jury
authors.initials: J
authors.lastname: Kim
authors.forename: Nam-Soo
authors.initials: NS
authors.lastname: Kim
authors.forename: Ki-Chang
authors.initials: KC
authors.lastname: Lee
authors.forename: Hae-Beom
authors.initials: HB
authors.lastname: Lee
authors.forename: Min-Su
authors.initials: MS
authors.lastname: Kim
authors.forename: Hyung-Seop
authors.initials: HS
authors.lastname: Kim
mesh_terms: D000758:Anesthesia / Q000379:methods / Q000662:veterinary*; D000779:Anesthetics, Local / Q000494:pharmacology; D000818:Animals; D003315:Cornea / Q000187:drug effects*; D004285:Dogs; D005260:Female; D007429:Intraocular Pressure / Q000187:drug effects*; D017288:Pain Threshold / Q000187:drug effects; D011430:Propoxycaine / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D014065:Tonometry, Ocular / Q000662:veterinary*
chemical_list: D000779:Anesthetics, Local; C005717:proxymetacaine; D011430:Propoxycaine