title: Resting state FDG-PET functional connectivity as an early biomarker of Alzheimer's disease using conjoint univariate and independent component analyses.
abstract: Imaging cerebral glucose metabolism with positron emission tomography (PET) in Alzheimer's disease (AD) has allowed for improved characterisation of this pathology. Such patterns are typically analysed using either univariate or multivariate statistical techniques. In this work we combined voxel-based group analysis and independent component analysis to extract differential characteristic patterns from PET data of glucose metabolism in a large cohort of normal elderly controls and patients with AD. The patterns were used in conjunction with a support vector machine to discriminate between subjects with mild cognitive impairment (MCI) at risk or not of converting to AD. The method was applied to baseline fluoro-deoxyglucose (FDG)-PET images of subjects from the ADNI database. Our approach achieved improved early detection and differentiation of typical versus pathological metabolic patterns in the MCI population, reaching 80% accuracy (85% sensitivity and 75% specificity) when using selected regions. The method has the potential to assist in the advance diagnosis of Alzheimer's disease, and to identify early in the development of the disease those individuals at high risk of rapid cognitive decline who could be candidates for new therapeutic approaches.
authors.affiliation: Laboratoire d'Imagerie Fonctionnelle, UMR-S 678, INSERM-UPMC, Paris, France. PauleJoanne.Toussaint@imed.jussieu.fr
authors.forename: Paule-Joanne
authors.initials: PJ
authors.lastname: Toussaint
authors.forename: Vincent
authors.initials: V
authors.lastname: Perlbarg
authors.forename: Pierre
authors.initials: P
authors.lastname: Bellec
authors.forename: Serge
authors.initials: S
authors.lastname: Desarnaud
authors.forename: Lucette
authors.initials: L
authors.lastname: Lacomblez
authors.forename: Julien
authors.initials: J
authors.lastname: Doyon
authors.forename: Marie-Odile
authors.initials: MO
authors.lastname: Habert
authors.forename: Habib
authors.initials: H
authors.lastname: Benali
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000000981:diagnostic imaging* / Q000378:metabolism; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism; D042241:Early Diagnosis; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D009434:Neural Pathways / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000502:physiology; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D012146:Rest / Q000502:physiology
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18