title: Successful delivery following ICSI with macrocephalic sperm head syndrome: a case report.
abstract: This article reports a case of macrocephalic sperm head syndrome, which is defined as the presence of a very high percentage of spermatozoa with enlarged heads and multiple flagellae, together with detailed morphological analysis. After a couple presented with infertility, sperm analysis showed severe teratozoospermia and almost all of the spermatozoa had macrocephaly with multiple tails. The morphological analysis revealed that most of the sperm heads contained several nuclei and had a similar number of tails as that of nuclei. However, detailed analysis revealed that there were a very few spermatozoa with an almost normal morphology. After genetic counselling, intracytoplasmic sperm injection was performed using a few spermatozoa that had an almost normal morphology, resulting in pregnancy and successful delivery. Even in macrocephalic sperm head syndrome, which may be caused by meiotic division failure, pregnancy is possible if some spermatozoa with almost normal morphology can be utilized, although there may be genetic risks.
authors.affiliation: Department of Obstetrics and Gynecology, Shiga University of Medical Science, Ohtsu, Shiga 520-2192, Japan. oshimi@belle.shiga-med.ac.jp
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Shimizu
authors.forename: Fuminori
authors.initials: F
authors.lastname: Kiumura
authors.forename: Shoji
authors.initials: S
authors.lastname: Kaku
authors.forename: Mika
authors.initials: M
authors.lastname: Izuno
authors.forename: Keiji
authors.initials: K
authors.lastname: Tomita
authors.forename: Dean
authors.initials: D
authors.lastname: Thumkeo
authors.forename: Takashi
authors.initials: T
authors.lastname: Murakami
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000628:therapy*; D008297:Male; D011247:Pregnancy; D011256:Pregnancy Outcome; D055101:Semen Analysis; D013077:Sperm Head; D020554:Sperm Injections, Intracytoplasmic; D013094:Spermatozoa / Q000002:abnormalities*; D013577:Syndrome; D016896:Treatment Outcome