title: Nanoparticle-mediated hyperthermia in cancer therapy.
abstract: A small rise in tumor temperature (hyperthermia) makes cancer cells more susceptible to radiation and chemotherapy. The means of achieving this is not trivial, and traditional methods have certain drawbacks. Loading tumors with systematically asministered energy-transducing nanoparticles can circumvent several of the obstacles to achieve tumor hyperthermia. However, nanoparticles also face unique challenges prior to clinical implementation. This article summarizes the state-of-the-art current technology and discusses the advantages and challenges of the three major nanoparticle formulations in focus: gold nanoshells and nanorods, superparamagnetic iron oxide particles and carbon nanotubes.
authors.affiliation: Department of Radiation Oncology, MD Anderson Cancer Center, Houston, TX 77030, USA.
authors.forename: Dev Kumar
authors.initials: DK
authors.lastname: Chatterjee
authors.forename: Parmeswaran
authors.initials: P
authors.lastname: Diagaradjane
authors.forename: Sunil
authors.initials: S
authors.lastname: Krishnan
mesh_terms: D005290:Ferric Compounds / Q000627:therapeutic use; D006046:Gold / Q000627:therapeutic use; D006108:Graphite / Q000627:therapeutic use / Q000633:toxicity; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D053768:Metal Nanoparticles / Q000627:therapeutic use*; D037742:Nanotubes, Carbon / Q000633:toxicity; D009369:Neoplasms / Q000628:therapy*
chemical_list: D005290:Ferric Compounds; D037742:Nanotubes, Carbon; C000499:ferric oxide; D006046:Gold; D006108:Graphite