title: Assessment of acute coronary syndromes: focus on novel biomarkers.
abstract: Coronary artery disease (CAD) is the leading cause of mortality in Western Societies and several developing countries. Recent evidence suggests that most detrimental clinical manifestations of CAD, such as acute coronary syndromes (ACS), are the outcome of inflammatory processes that lead to plaque formation and rupture and eventually to ischemia and potentially myocardial necrosis. Neither of the traditionally used biomarkers is thought to be the gold standard in detection of myocardial ischemia or necrosis. A biomarker that could detect quite early the ischemic myocardium as well as define the risk of a future event with high sensitivity and specificity is still lacking. Several biomarkers, implicated in the pathogenesis and clinical evolution of atherosclerosis, have emerged as potent biomarkers for early detection of myocardial ischemia. In the current review, we summarize recent evidence of the most promising biomarkers and discuss their potential role in clinical practice in patients suffering from ACSs.
authors.affiliation: 1st Cardiology Unit, Athens University Medical School, Greece. drtousoulis@hotmail.com
authors.forename: D
authors.initials: D
authors.lastname: Tousoulis
authors.forename: G
authors.initials: G
authors.lastname: Hatzis
authors.forename: N
authors.initials: N
authors.lastname: Papageorgiou
authors.forename: E
authors.initials: E
authors.lastname: Androulakis
authors.forename: G
authors.initials: G
authors.lastname: Bouras
authors.forename: A
authors.initials: A
authors.lastname: Giolis
authors.forename: C
authors.initials: C
authors.lastname: Bakogiannis
authors.forename: G
authors.initials: G
authors.lastname: Siasos
authors.forename: G
authors.initials: G
authors.lastname: Latsios
authors.forename: C
authors.initials: C
authors.lastname: Antoniades
authors.forename: C
authors.initials: C
authors.lastname: Stefanadis
mesh_terms: D054058:Acute Coronary Syndrome / Q000378:metabolism*; D015415:Biomarkers / Q000378:metabolism*; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D017202:Myocardial Ischemia / Q000378:metabolism; D018384:Oxidative Stress
chemical_list: D015415:Biomarkers