title: LAPTM4B allele *2 is a marker of poor prognosis following hepatic tumor resection for hepatocellular carcinoma.
abstract: BACKGROUND
  Lysosomal protein transmembrane 4 beta (LAPTM4B) is a gene related to hepatocellular carcinoma that has two alleles designated LAPTM4B*1 and LAPTM4B*2. This study aimed to investigate the correlation of LAPTM4B genotype with prognosis and clinicopathologic features in patients who have undergone resection for hepatocellular carcinoma (HCC).
  
  
  RESULTS
  The LAPTM4B genotype was analyzed by PCR in 68 patients who had undergone curative hepatic resection for hepatocellular carcinoma. The correlation of LAPTM4B genotype with clinicopathologic parameters was assessed with the Chi-squared test. Differences in patient survival were determined by the Kaplan-Meier method. Multivariate analysis of prognostic factors was carried out with Cox regression analysis. Patients with LAPTM4B *2 had both significantly shorter overall survival (OS) and shorter disease-free survival (DFS) (both P<0.001). Multivariate analysis showed that LAPTM4B genotype is an independent prognostic factor for OS and DFS (both P<0.001).
  
  
  CONCLUSIONS
  Allele *2 of LAPTM4B is a risk factor associated with poor prognosis in patients with resected HCC. LAPTM4B status may be useful preoperatively as an adjunct in evaluation of the operability of HCC.
authors.affiliation: Department of Cell Biology, School of Basic Medical Sciences, Peking University, Beijing, China. yanghua@bjmu.edu.cn
authors.forename: Hua
authors.initials: H
authors.lastname: Yang
authors.forename: Guojun
authors.initials: G
authors.lastname: Zhai
authors.forename: Xiaoxu
authors.initials: X
authors.lastname: Ji
authors.forename: Fuxia
authors.initials: F
authors.lastname: Xiong
authors.forename: Jing
authors.initials: J
authors.lastname: Su
authors.forename: Michael A
authors.initials: MA
authors.lastname: McNutt
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D006528:Carcinoma, Hepatocellular / Q000097:blood / Q000235:genetics* / Q000601:surgery; D018572:Disease-Free Survival; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D053208:Kaplan-Meier Estimate; D008113:Liver Neoplasms / Q000097:blood / Q000235:genetics* / Q000601:surgery; D008297:Male; D008565:Membrane Proteins / Q000097:blood / Q000235:genetics*; D008875:Middle Aged; D015513:Oncogene Proteins / Q000097:blood / Q000235:genetics*; D011379:Prognosis
chemical_list: C477083:LAPTM4B protein, human; D008565:Membrane Proteins; D015513:Oncogene Proteins