title: Randomised weaning trial comparing assist control to pressure support ventilation.
abstract: OBJECTIVE
  To determine if the work of breathing was lower, respiratory muscle strength greater, but the degree of asynchrony higher during weaning by assist control ventilation (ACV) rather than pressure support ventilation (PSV) and if any differences were associated with a shorter duration of weaning.
  
  
  METHODS
  Randomised trial
  
  
  METHODS
  Tertiary neonatal unit
  
  
  METHODS
  Thirty-six infants, median gestational age 29 (range 24 to 39) weeks
  
  
  METHODS
  Weaning by either ACV or PSV.
  
  
  METHODS
  At baseline, 24 hours after entering the study and immediately prior to extubation, the work of breathing (PTPdi), thoracoabdominal asynchrony (TAA) and respiratory muscle strength (Pimax) were assessed and weaning duration recorded.
  
  
  RESULTS
  There were no significant differences in the median PTPdi, TAA and Pimax results at any time point. The inflation times during ACV and PSV were similar. The median duration of weaning was 34 (range 7-100) hours in the ACV group and 27 (range 10-169) hours in the PSV group (p=0.88).
  
  
  CONCLUSIONS
  No significant differences were found between weaning by PSV and ACV when similar inflation times were used.
authors.affiliation: Division of Asthma, Allergy and Lung Biology, Kings College London, London, UK.
authors.forename: Deena
authors.initials: D
authors.lastname: Shefali-Patel
authors.forename: Vadivelam
authors.initials: V
authors.lastname: Murthy
authors.forename: Simon
authors.initials: S
authors.lastname: Hannam
authors.forename: Silke
authors.initials: S
authors.lastname: Lee
authors.forename: Gerrard F
authors.initials: GF
authors.lastname: Rafferty
authors.forename: Anne
authors.initials: A
authors.lastname: Greenough
mesh_terms: D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011175:Positive-Pressure Respiration / Q000379:methods*; D012119:Respiration; D012121:Respiration, Artificial / Q000379:methods*; D016896:Treatment Outcome; D015300:Ventilator Weaning / Q000379:methods*; D014939:Work of Breathing