title: Yellow fever virus susceptibility of two mosquito vectors from Kenya, East Africa.
abstract: Yellow fever is an unpredictable disease of increasing epidemic threat in East Africa. Aedes (Stegomyia) aegypti has never been implicated as a vector in this region and recent outbreaks have involved a newly emerging virus genotype (East African). To better understand the increasing epidemic risk of yellow fever in East Africa, this study is the first to investigate the vector competence for an emerging East African virus genotype in Kenyan A. aegypti sensu latu (s.l) and A. (Stegomyia) simpsoni s.l. mosquito species. Using first filial generation mosquitoes and a low passage yellow fever virus, this study demonstrated that although A. aegypti s.l. is a competent vector, A. simpsoni s.l. is likely a more efficient vector.
authors.affiliation: Department of Tropical Medicine, Tulane University, 1440 Canal Street Suite 2210-SL17, New Orleans, Louisiana 70112, USA. brett.ellis@duke-nus.edu.sg
authors.forename: Brett R
authors.initials: BR
authors.lastname: Ellis
authors.forename: Rosemary C
authors.initials: RC
authors.lastname: Sang
authors.forename: Kate McElroy
authors.initials: KM
authors.lastname: Horne
authors.forename: Stephen
authors.initials: S
authors.lastname: Higgs
authors.forename: Dawn M
authors.initials: DM
authors.lastname: Wesson
mesh_terms: D000330:Aedes / Q000235:genetics; D000818:Animals; D004196:Disease Outbreaks; D005838:Genotype; D006801:Humans; D007303:Insect Vectors / Q000235:genetics; D007630:Kenya / Q000453:epidemiology; D013045:Species Specificity; D015004:Yellow Fever / Q000453:epidemiology* / Q000635:transmission*; D015005:Yellow fever virus / Q000472:pathogenicity*