title: Liver hypertrophy and accelerated growth of implanted tumors in nonembolized liver of rabbit after left portal vein embolization.
abstract: BACKGROUND
  Portal vein embolization (PVE) has become a standard preoperative procedure to promote hypertrophy of the future remnant liver to reduce postoperative liver failure. Whether PVE accelerates tumor growth is still controversial. We developed a left PVE procedure and investigated its effect on liver hypertrophy and tumor growth in a rabbit liver tumor model.
  
  
  METHODS
  VX2 tumors were implanted in both the external left and right middle lobe (the bilateral group) or in the external left lobe only (the unilateral group) of rabbit liver. Both groups were further divided into a PVE or a sham/control group. Tumor volume and tumor growth rate as volume relative increase were determined by ultrasound. Liver volume-to-body weight index, an index for liver volume, was compared. Serum HGF was measured by ELISA.
  
  
  RESULTS
  In the bilateral PVE group, tumor volume and relative increase value in the nonembolized lobe were significantly (71% and 65%, respectively) greater than those in the control group at 5 d post-PVE. In the unilateral PVE group, liver volume-to-body weight index of the nonembolized lobes was significantly increased by 17%. Increase of serum HGF level after PVE was correlated well with both tumor growth and liver hypertrophy.
  
  
  CONCLUSIONS
  Left PVE promoted both the growth of implanted tumors and liver hypertrophy in the nonembolized liver, in which serum HGF might play an important role.
authors.affiliation: State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China.
authors.forename: Ru-hai
authors.initials: RH
authors.lastname: Zou
authors.forename: An-hua
authors.initials: AH
authors.lastname: Li
authors.forename: Feng
authors.initials: F
authors.lastname: Han
authors.forename: Jian
authors.initials: J
authors.lastname: Hong
authors.forename: Bin-kui
authors.initials: BK
authors.lastname: Li
authors.forename: Wei
authors.initials: W
authors.lastname: Huang
authors.forename: Liang
authors.initials: L
authors.lastname: Huang
authors.forename: Yun-fei
authors.initials: YF
authors.lastname: Yuan
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D004195:Disease Models, Animal; D004621:Embolization, Therapeutic / Q000009:adverse effects*; D017228:Hepatocyte Growth Factor / Q000097:blood; D006984:Hypertrophy / Q000097:blood / Q000000981:diagnostic imaging / Q000473:pathology; D017093:Liver Failure / Q000097:blood / Q000000981:diagnostic imaging / Q000473:pathology*; D008113:Liver Neoplasms / Q000097:blood / Q000000981:diagnostic imaging / Q000473:pathology*; D009368:Neoplasm Transplantation; D011169:Portal Vein / Q000473:pathology*; D011183:Postoperative Complications / Q000097:blood / Q000000981:diagnostic imaging / Q000473:pathology*; D011817:Rabbits; D047368:Tumor Burden; D014463:Ultrasonography
chemical_list: D017228:Hepatocyte Growth Factor