title: Antibacterial activity of xanthones from Garcinia mangostana (L.) and their structure-activity relationship studies.
abstract: Antibacterial activities of prenylated xanthones from Garcinia mangostana and their synthetic analogues were investigated, and their structure-activity relationships have been studied. γ-Mangostin has shown antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA), methicillin sensitive Staphylococcus aureus (MSSA), vancomycin-resistant Enterococcus (VRE) and vancomycin-sensitive Enterococcus (VSE) strains at MICs 3.13, 6.25, 6.25 and 6.25 µg mL(-1), respectively. In these experiments, gentamicin was used as the positive control. Further, some analogues of γ-mangostin and α-mangostin were synthesised and their activity was tested against MRSA and VRE strains. The analysis of the bioassay results above indicated that, the combination of C-6 and C-3 hydroxyl groups along with the prenyl side chain at C-2 in the 1,3,6,7-tetraoxygenated xanthones from G. mangostana is essential to have a high antibacterial activity.
authors.affiliation: Natural Products Programme, Institute of Fundamental Studies, Kandy, Sri Lanka. rwdharma@olemiss.edu
authors.forename: H R W
authors.initials: HR
authors.lastname: Dharmaratne
authors.forename: Yoshikazu
authors.initials: Y
authors.lastname: Sakagami
authors.forename: K G P
authors.initials: KG
authors.lastname: Piyasena
authors.forename: Vasanthi
authors.initials: V
authors.lastname: Thevanesam
mesh_terms: D016983:Enterococcus / Q000187:drug effects; D029762:Garcinia mangostana / Q000737:chemistry*; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship; D020713:Vancomycin Resistance; D044004:Xanthones / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D044004:Xanthones; C021053:mangostin