title: Microstructure, mechanical properties, biocorrosion behavior, and cytotoxicity of as-extruded Mg-Nd-Zn-Zr alloy with different extrusion ratios.
abstract: Recently, commercial magnesium (Mg) alloys containing Al (such as AZ31 and AZ91) or Y (such as WE43) have been studied extensively for biomedical applications. However, these Mg alloys were developed as structural materials, not as biomaterials. In this study, a patented Mg-Nd-Zn-Zr (denoted as JDBM) alloy was investigated as a biomedical material. The microstructure, mechanical properties, biocorrosion behavior, and cytotoxicity of the alloy extruded at 320 °C with extrusion ratios of 8 and 25 were studied. The results show that the lower extrusion ratio results in finer grains and higher strength, but lower elongation, while the higher extrusion ratio results in coarser grains and lower strength, but higher elongation. The biocorrosion behavior of the alloy was investigated by hydrogen evolution and mass loss tests in simulated body fluid (SBF). The results show that the alloy extruded with lower extrusion ratio exhibits better corrosion resistance. The corrosion mode of the alloy is uniform corrosion, which is favorable for biomedical applications. Aging treatment on the as-extruded alloy improves the strength and decreases the elongation at room temperature, and has a small positive influence on the corrosion resistance in SBF. The cytotoxicity test indicates that the as-extruded JDBM alloy meets the requirement of cell toxicity.
authors.affiliation: National Engineering Research Center of Light Alloy Net Forming, Shanghai Jiao Tong University, Shanghai 200240, China.
authors.forename: Xiaobo
authors.initials: X
authors.lastname: Zhang
authors.forename: Guangyin
authors.initials: G
authors.lastname: Yuan
authors.forename: Jialin
authors.initials: J
authors.lastname: Niu
authors.forename: Penghuai
authors.initials: P
authors.lastname: Fu
authors.forename: Wenjiang
authors.initials: W
authors.lastname: Ding
mesh_terms: D000497:Alloys / Q000737:chemistry*; D000818:Animals; D001672:Biocompatible Materials / Q000032:analysis; D001826:Body Fluids / Q000737:chemistry; D002470:Cell Survival; D003343:Corrosion; D004583:Electrons; D006801:Humans; D008274:Magnesium / Q000737:chemistry*; D008422:Materials Testing; D051379:Mice; D008855:Microscopy, Electron, Scanning / Q000379:methods; D009354:Neodymium / Q000737:chemistry*; D013314:Stress, Mechanical; D013696:Temperature; D013778:Tetrazolium Salts / Q000494:pharmacology; D013844:Thiazoles / Q000494:pharmacology; D015032:Zinc / Q000737:chemistry*; D015040:Zirconium / Q000737:chemistry*
chemical_list: D000497:Alloys; D001672:Biocompatible Materials; D013778:Tetrazolium Salts; D013844:Thiazoles; D009354:Neodymium; D015040:Zirconium; C022616:thiazolyl blue; D008274:Magnesium; D015032:Zinc