title: [Progress in mechanisms underlying melamine toxicity in central nervous system].
abstract: In recent years there have been more widely and deeply studies in investigating melamine toxicity. Generally, it is believed that the main target of melamine is the urinary system. However, previous studies revealed that it also had additional biological actions. Obviously, the toxicity mechanisms of melamine have not been fully clarified. It is well known that fetus and infant periods play the most fundamental role in the brain development. And melamine can pass through the placental and blood-brain barrier, and then exerts toxic effects on the central nervous system. This article reviewed the reports about the topic in recent years, for better understanding the dangers of melamine to infants and providing experimental data for further study.
authors.affiliation: College of Life Science, Nankai University, Tianjin, China.
authors.forename: Jia-Jia
authors.initials: JJ
authors.lastname: Yang
authors.forename: Lei
authors.initials: L
authors.lastname: An
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Yang
authors.forename: Tao
authors.initials: T
authors.lastname: Zhang
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects; D001921:Brain / Q000254:growth & development; D002490:Central Nervous System / Q000187:drug effects*; D003071:Cognition / Q000187:drug effects; D005260:Female; D006801:Humans; D008431:Maternal-Fetal Exchange / Q000187:drug effects; D011247:Pregnancy; D014227:Triazines / Q000493:pharmacokinetics / Q000633:toxicity*
chemical_list: D014227:Triazines; C011907:melamine