title: Meta-analysis of the association between the interleukin-1A -889C/T polymorphism and Alzheimer's disease.
abstract: No clear consensus has been reached on the Interleukin-1A (IL-1A) -889C/T polymorphism and Alzheimer's disease (AD) risk. In this meta-analysis, 27 case-control studies were assessed to evaluate the possible association. Overall, positive associations of the IL-1A -889C/T polymorphism with AD risk were found in allele comparison T vs. C (OR = 1.09, 95% CI = 1.01-1.18), recessive model TT vs. CT + CC (OR = 1.21, 95% CI = 1.01-1.45), and homozygote comparison (TT vs. CC; OR = 1.32, 95% CI = 1.04-1.67). In subgroup analysis stratified by ethnicity, significant associations were demonstrated in Caucasians but not in Asians. In subgroup analysis according to the age of onset, the data showed a significant association in patients with late-onset AD in Caucasians but not in early-onset AD. In conclusion, this meta-analysis supports the idea that IL-1A -889C/T polymorphism is capable of causing AD and LOAD susceptibility in Caucasians but not in Asians.
authors.affiliation: Department of Neurology, The Affiliated Wuxi Second Hospital, Nanjing Medical University, Wuxi, Jiangsu, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Hua
authors.forename: Hui
authors.initials: H
authors.lastname: Zhao
authors.forename: Yuenan
authors.initials: Y
authors.lastname: Kong
authors.forename: Xiaojie
authors.initials: X
authors.lastname: Lu
mesh_terms: D017668:Age of Onset; D000544:Alzheimer Disease / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005838:Genotype; D006801:Humans; D053582:Interleukin-1alpha / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D044465:White People / Q000235:genetics
chemical_list: D053582:Interleukin-1alpha