title: Biomimetic detection of aminoglycosidic antibiotics using polydiacetylene-phospholipids supramolecules.
abstract: We rationally designed highly sensitive and selective polydiacetylene (PDA)-phospholipids liposomes for the facile detection of aminoglycosidic antibiotics. The detecting mechanism mimics the cellular membrane interactions between neomycin and phosphatidylinositol-4,5-bisphosphate (PIP(2)) phospholipids. The developed PDA-PIP(2) sensory system showed a detection limit of 61 ppb for neomycin and was very specific to aminoglycosidic antibodies only.
authors.affiliation: School of Mechanical and Aerospace Engineering, Seoul National University, Seoul 151-742, Korea.
authors.forename: Do Hyun
authors.initials: DH
authors.lastname: Kang
authors.forename: Ho-Sup
authors.initials: HS
authors.lastname: Jung
authors.forename: Namyoung
authors.initials: N
authors.lastname: Ahn
authors.forename: Jiseok
authors.initials: J
authors.lastname: Lee
authors.forename: Sungbaek
authors.initials: S
authors.lastname: Seo
authors.forename: Kahp-Yang
authors.initials: KY
authors.lastname: Suh
authors.forename: Jinsang
authors.initials: J
authors.lastname: Kim
authors.forename: Keesung
authors.initials: K
authors.lastname: Kim
mesh_terms: D000900:Anti-Bacterial Agents / Q000032:analysis*; D032701:Biomimetics; D008081:Liposomes / Q000737:chemistry; D008856:Microscopy, Fluorescence; D009355:Neomycin / Q000032:analysis; D010743:Phospholipids / Q000737:chemistry*; D000078789:Polyacetylene Polymer; D011108:Polymers / Q000737:chemistry*; D053279:Polyynes / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D008081:Liposomes; D010743:Phospholipids; D000078789:Polyacetylene Polymer; D011108:Polymers; D053279:Polyynes; C082361:polydiacetylene; D009355:Neomycin