title: The economic impact of galantamine vs placebo: an analysis based on functional capacity in a Swedish cohort study.
abstract: OBJECTIVE
  To analyse the economic impact of galantamine, based on basic activities of daily living (ADL).
  
  
  METHODS
  Data were derived from Swedish patients enrolled in a 6-month placebo-controlled trial of galantamine (GAL-INT-1; n=80), and from the Kungsholmen-Nordanstig Project, a longitudinal study of 919 elderly persons in Sweden. Basic ADL were assessed using the Katz' Index of Independence in Activities of Daily Living (ADL) (number of ADL lost [dependency in 0, 1-2, 3-4, or 5-6 ADL]). Costs were appraised based on regression analysis and on costs directly linked to ADL. Six-month costs for galantamine and placebo were calculated.
  
  
  RESULTS
  In the regression analyses, each increase in a Katz stage was associated with an annual cost increase of SEK 81,415-83,683 (∼€8000). Results were similar using stage-specific costs. Overall, there was a small, non-significant numerical cost benefit for galantamine indicating cost neutrality.
  
  
  CONCLUSIONS
  The small number of Swedish patients in the GAL-INT-1 study, which was not powered for economic outcomes, limits the statistical power of the analysis. In addition, long-term outcomes are difficult to assess in persons with dementia because of practical and logistical problems.
  
  
  CONCLUSIONS
  The benefits of galantamine in patients with AD can be achieved with no increase in cost. Combined with positive effects in terms of outcome, treatment with galantamine can be regarded as cost-effective using a cost-consequence approach.
authors.affiliation: Aging Research Center, Dept NVS, Karolinska Institutet, Stockholm, Sweden. anders.wimo@ki.se
authors.forename: Anders
authors.initials: A
authors.lastname: Wimo
authors.forename: Maren
authors.initials: M
authors.lastname: Gaudig
authors.forename: Barbara
authors.initials: B
authors.lastname: Schäuble
authors.forename: Erik
authors.initials: E
authors.lastname: Jedenius
mesh_terms: D000203:Activities of Daily Living / Q000523:psychology*; D015331:Cohort Studies; D003704:Dementia / Q000188:drug therapy / Q000191:economics; D004311:Double-Blind Method; D005702:Galantamine / Q000191:economics* / Q000627:therapeutic use; D017048:Health Care Costs; D006801:Humans; D008137:Longitudinal Studies; D018697:Nootropic Agents / Q000191:economics* / Q000627:therapeutic use; D012044:Regression Analysis; D013548:Sweden
chemical_list: D018697:Nootropic Agents; D005702:Galantamine