title: A focus on antiarrhythmic properties of ranolazine.
abstract: Ranolazine is an antianginal drug that inhibits a number of ion currents that are important for the genesis of transmembrane cardiac action potential. It was initially developed as an antianginal agent but was found to additionally exert antiarrhythmic actions, due to its multichannel-blocking properties. In recent years, several studies about the antiarrhythmic properties of ranolazine were conducted, demonstrating the beneficial effects of this drug in both atrial and ventricular arrhythmias, such as atrial fibrillation, ventricular premature beats, ventricular tachycardia, torsades de pointes, and ventricular fibrillation. Our aim is to briefly review the main points of these studies, most more experimental than clinical.
authors.affiliation: Department of Applied and Experimental Medicine, Chair of Cardiology University of Brescia, Brescia, Italy. enrico.vizzardi@tin.it
authors.forename: Enrico
authors.initials: E
authors.lastname: Vizzardi
authors.forename: Antonio
authors.initials: A
authors.lastname: D'Aloia
authors.forename: Filippo
authors.initials: F
authors.lastname: Quinzani
authors.forename: Ivano
authors.initials: I
authors.lastname: Bonadei
authors.forename: Riccardo
authors.initials: R
authors.lastname: Rovetta
authors.forename: Luca
authors.initials: L
authors.lastname: Bontempi
authors.forename: Antonio
authors.initials: A
authors.lastname: Curnis
authors.forename: Livio
authors.initials: L
authors.lastname: Dei Cas
mesh_terms: D000083:Acetanilides / Q000494:pharmacology / Q000627:therapeutic use*; D000200:Action Potentials; D000787:Angina Pectoris / Q000188:drug therapy / Q000378:metabolism; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000378:metabolism; D006325:Heart Atria / Q000187:drug effects / Q000378:metabolism; D006352:Heart Ventricles / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007473:Ion Channels / Q000037:antagonists & inhibitors / Q000378:metabolism; D049990:Membrane Transport Modulators / Q000494:pharmacology / Q000627:therapeutic use; D010879:Piperazines / Q000494:pharmacology / Q000627:therapeutic use*; D000069458:Ranolazine
chemical_list: D000083:Acetanilides; D000889:Anti-Arrhythmia Agents; D007473:Ion Channels; D049990:Membrane Transport Modulators; D010879:Piperazines; D000069458:Ranolazine