title: Iron-catalyzed cyclopropanation with glycine ethyl ester hydrochloride in water.
abstract: An iron-catalyzed cyclopropanation reaction of styrenes in aqueous media is disclosed that employs glycine ethyl ester hydrochloride in a tandem diazotization/cyclopropanation reaction. The products are accessed in good yields and good diastereoselectivity using readily available and inexpensive starting materials. Moreover, a wide range of transition metals may be used under these conditions, thus opening new opportunities for efficient carbene-transfer reactions under user-friendly conditions.
authors.affiliation: Laboratory of Organic Chemistry, ETH-Zürich , HCI H335, Wolfgang-Pauli-Strasse 10, 8093 Zürich, Switzerland.
authors.forename: Bill
authors.initials: B
authors.lastname: Morandi
authors.forename: Amund
authors.initials: A
authors.lastname: Dolva
authors.forename: E M
authors.initials: EM
authors.lastname: Carreira