title: Prevalence and risk factors for intraoperative hypotension during craniotomy for traumatic brain injury.
abstract: BACKGROUND
  Hypotension after traumatic brain injury (TBI) is associated with poor outcomes. However, data on intraoperative hypotension (IH) are scarce and the effect of anesthetic agents on IH is unknown. We examined the prevalence and risk factors for IH, including the effect of anesthetic agents during emergent craniotomy for isolated TBI.
  
  
  METHODS
  This is a retrospective cohort study of patients 18 years and above, who underwent emergent craniotomy for TBI at Harborview Medical Center (level 1 trauma center) between October 2007 and January 2010. Demographic, clinical, and radiographic characteristics and hemodynamic and anesthetic data were abstracted from medical and electronic anesthesia records. Hypotension was defined as systolic blood pressure <90 mm Hg. Univariate analyses were performed to compare the clinical characteristics of patients with and without IH, and multiple logistic regression analysis was used to determine independent risk factors for IH.
  
  
  RESULTS
  Data abstracted from 113 eligible patients aged 48±19 years were analyzed. IH was common (n=73, 65%) but not affected by the choice of anesthetic agent. Independent risk factors for IH were multiple computed tomographic (CT) lesions [adjusted odds ratios (AOR) 19.1; 95% confidence interval (CI), 2.08-175.99; P=0.009], subdural hematoma (AOR 17.9; 95% CI, 2.97-108.10; P=0.002), maximum CT lesion thickness (AOR 1.1; 95% CI, 1.01-1.13; P=0.016), and anesthesia duration (AOR 1.1; 95% CI, 1.01-1.30; P=0.009).
  
  
  CONCLUSIONS
  IH was common in adult patients with isolated TBI undergoing emergent craniotomy. The presence of multiple CT lesions, subdural hematoma, maximum thickness of CT lesion, and longer duration of anesthesia increase the risk for IH.
authors.affiliation: Department of Anesthesiology & Pain Medicine, University of Washington, Seattle, WA 98104, USA. dsharma@uw.edu
authors.forename: Deepak
authors.initials: D
authors.lastname: Sharma
authors.forename: Michelle J
authors.initials: MJ
authors.lastname: Brown
authors.forename: Parichat
authors.initials: P
authors.lastname: Curry
authors.forename: Sakura
authors.initials: S
authors.lastname: Noda
authors.forename: Randall M
authors.initials: RM
authors.lastname: Chesnut
authors.forename: Monica S
authors.initials: MS
authors.lastname: Vavilala
mesh_terms: D001930:Brain Injuries / Q000601:surgery*; D015984:Causality; D015331:Cohort Studies; D003399:Craniotomy / Q000379:methods*; D005260:Female; D006408:Hematoma, Subdural / Q000453:epidemiology; D006801:Humans; D007022:Hypotension / Q000453:epidemiology*; D007431:Intraoperative Complications / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors; D013997:Time Factors