title: [Neuroprotective effect of ferulic acid in vitro].
abstract: OBJECTIVE
  To investigate the neuroprotective effect of ferulic acid on PC12 cells injuries.
  
  
  METHODS
  With three models of PC12 cells injured by hypoxia, excitatory amino acids (EAA) and radical, the effect of ferulic acid on injured PC12 cells was observed by MTT assay.
  
  
  RESULTS
  Compared with three models, ferulic acid (1-100 micromol/L) could promote cell viability notably (P<0.05 or P<0.01).
  
  
  CONCLUSIONS
  Ferulic acid has notable protective effect on PC12 cells injured by hypoxia, EAA and radical.
authors.affiliation: Guangdong College of Pharmacy, Guangzhou 510006, China. luolan1105@126.com
authors.forename: Lan
authors.initials: L
authors.lastname: Luo
authors.forename: Yue
authors.initials: Y
authors.lastname: Sun
mesh_terms: D000818:Animals; D015687:Cell Hypoxia; D049109:Cell Proliferation / Q000187:drug effects; D003373:Coumaric Acids / Q000494:pharmacology*; D015140:Dementia, Vascular / Q000517:prevention & control*; D016166:Free Radical Scavengers / Q000494:pharmacology*; D018698:Glutamic Acid / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000378:metabolism; D018696:Neuroprotective Agents / Q000494:pharmacology*; D016716:PC12 Cells; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats
chemical_list: D003373:Coumaric Acids; D016166:Free Radical Scavengers; D018696:Neuroprotective Agents; D018698:Glutamic Acid; C004999:ferulic acid; D006861:Hydrogen Peroxide