title: [Expression of manganese superoxide dismutase in colorectal carcinoma and its relationship with clinicopathological findings].
abstract: OBJECTIVE
  To explore the expression of manganese superoxide dismutase (MnSOD) in colorectal carcinoma and its relationship with the clinicopathological findings.
  
  
  METHODS
  The expressions of MnSOD in colorectal carcinoma, adenoma, and adjacent corresponding intestinal mucosal tissues were detected by immunohistochemistry and reverse transcription-polymerase chain reaction (RT-PCR). The relationship between MnSOD expression level in colorectal adenoma and clinical parameters was analyzed.
  
  
  RESULTS
  The expression of MnSOD was negative in adjacent corresponding colorectal tissues. The positive expression rate of MnSOD was 44% (11/25) in colorectal adenoma and 76% (19/25) in colorectal carcinoma (P < 0.05 when compared with the colorectal adenoma and its adjacent tissues). The expression of MnSOD was positively correlated with histopathological grades (P < 0.05) but not with other clinicopathological findings (P > 0.05).
  
  
  CONCLUSIONS
  The expression of MnSOD may be associated with the carcinogenesis and progression of colorectal carcinoma, and therefore may be used as a new biomarker.
authors.affiliation: Department of Gastroenterology, General Hospital of Jinan Military Command, Jinan 250031, China.
authors.forename: Xiao
authors.initials: X
authors.lastname: Li
authors.forename: Zi-Qin
authors.initials: ZQ
authors.lastname: Sun
authors.forename: Zhi
authors.initials: Z
authors.lastname: Wei
authors.forename: Jing
authors.initials: J
authors.lastname: Niu
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Liu
authors.forename: Wei
authors.initials: W
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D015179:Colorectal Neoplasms / Q000201:enzymology* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013482:Superoxide Dismutase / Q000378:metabolism*
chemical_list: D013482:Superoxide Dismutase