title: Tracer kinetics and metabolic models in medicine.
abstract: In the present paper, a survey of methods applied to the interpretation and evaluation of tracer kinetic data is given. For their mathematical description, both compartmental and non-compartmental models, such as the modified model of Sprinson and Rittenberg, the San Pietro-Rittenberg model, two models of the albumin metabolism and a 10-pool model of the N and protein metabolism were used. By means of single or multiple pulse, infusion and priming techniques, the N and protein metabolism in various metabolic states (e.g. healthy man, pathological and stress conditions, therapeutic treatments) were studied.
authors.affiliation: Central Institute for Isotope and Radiation Research, Academy of Sciences of the GDR, Leipzig, Germany. junghans@fbn-dummerstorf.de
authors.forename: Peter
authors.initials: P
authors.lastname: Junghans
authors.forename: Barbara
authors.initials: B
authors.lastname: Wagner
authors.forename: Andreas
authors.initials: A
authors.lastname: Nickel
authors.forename: Hans
authors.initials: H
authors.lastname: Faust
mesh_terms: D000418:Albumins / Q000378:metabolism; D015510:Clinical Medicine / Q000379:methods*; D003198:Computer Simulation; D006801:Humans; D007700:Kinetics; D008107:Liver Diseases / Q000097:blood / Q000378:metabolism / Q000652:urine; D008954:Models, Biological; D009584:Nitrogen / Q000378:metabolism* / Q000652:urine; D009587:Nitrogen Isotopes / Q000097:blood / Q000652:urine; D014176:Protein Biosynthesis / Q000502:physiology; D011506:Proteins / Q000378:metabolism*; D013315:Stress, Psychological / Q000097:blood / Q000378:metabolism / Q000652:urine
chemical_list: D000418:Albumins; D009587:Nitrogen Isotopes; D011506:Proteins; D009584:Nitrogen