title: [Synthesis and anti-tumor activity of paeonol and its derivatives].
abstract: A series of paeonol derivatives have been synthesized by simple acylation and etherification of the paeonol. Anti-tumor activities of the synthesized compounds were evaluated against HeLa and MCF-7 cells lines in vitro by the standard MTT assay. It was found that the derivatives were more active against HeLa than MCF-7. The results also indicated that 4-methoxy group is the synergistic group of paeonol's anti-tumor activity and ketone carbonyl side chain is essential functional group of paeonol's anti-tumor activity. Compound 2d had stronger antiproliferative activities than paeonol against HeLa and MCF-7 cell lines with IC50 values of 2.67 and 4.74 micromol x L(-1) respectively. The results showed that paeonol derivatives were worth to be intensively studied further.
authors.affiliation: Key Laboratory of Resource Biology and Biotechnology in West China, Ministry of Education, School of Life Science, Northwest University, Xi'an 710069, China.
authors.forename: Xue-Jun
authors.initials: XJ
authors.lastname: Wang
authors.forename: Jian-Li
authors.initials: JL
authors.lastname: Liu
authors.forename: Jiang-Kai
authors.initials: JK
authors.lastname: Wang
mesh_terms: D000098:Acetophenones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D049109:Cell Proliferation / Q000187:drug effects*; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D061986:MCF-7 Cells; D013329:Structure-Activity Relationship
chemical_list: D000098:Acetophenones; D000972:Antineoplastic Agents, Phytogenic; C013638:paeonol