title: Overcoming "aspirin resistance" in MPN.
abstract: In this issue of Blood, Pascale and colleagues show that biochemical resistance to aspirin in patients with essential thrombocythemia (ET) can be reversed by twice daily dosing.
authors.affiliation: Mayo Clinic.
authors.forename: Ayalew
authors.initials: A
authors.lastname: Tefferi
mesh_terms: D001241:Aspirin / Q000627:therapeutic use*; D051545:Cyclooxygenase 1 / Q000378:metabolism*; D051546:Cyclooxygenase 2 / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D013920:Thrombocythemia, Essential / Q000188:drug therapy* / Q000378:metabolism*; D013928:Thromboxane A2 / Q000096:biosynthesis*
chemical_list: D013928:Thromboxane A2; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D001241:Aspirin