title: Direct palladium(II)-catalyzed synthesis of arylamidines from aryltrifluoroborates.
abstract: A fast and convenient synthesis of arylamidines starting from readily available potassium aryltrifluoroborates and cyanamides is reported. The coupling was achieved by Pd(II)-catalysis in a one step 20 min microwave protocol using Pd(O(2)CCF(3)), 6-methyl-2,2'-bipyridyl, TFA, and MeOH, providing the corresponding arylamidines in moderate to excellent yields.
authors.affiliation: Organic Pharmaceutical Chemistry, Department of Medicinal Chemistry BMC, Uppsala University, Box 574, SE-751 23, Uppsala, Sweden.
authors.forename: Jonas
authors.initials: J
authors.lastname: Sävmarker
authors.forename: Jonas
authors.initials: J
authors.lastname: Rydfjord
authors.forename: Johan
authors.initials: J
authors.lastname: Gising
authors.forename: Luke R
authors.initials: LR
authors.lastname: Odell
authors.forename: Mats
authors.initials: M
authors.lastname: Larhed
mesh_terms: D000578:Amidines / Q000138:chemical synthesis* / Q000737:chemistry; D001881:Borates / Q000737:chemistry*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003484:Cyanamide / Q000737:chemistry; D008872:Microwaves; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D011188:Potassium / Q000737:chemistry
chemical_list: D000578:Amidines; D001881:Borates; D003484:Cyanamide; D010165:Palladium; D011188:Potassium