title: Novel 1,2,4-triazolo[1,5-a]pyridines and their fused ring systems attenuate oxidative stress and prolong lifespan of Caenorhabiditis elegans.
abstract: In this paper we report the synthesis of some novel 1,2,4-triazolo[1,5-a]pyridine and azolotriazolopyridine ring systems. The products were screened for various types of activity like antibacterial, antifungal, and antioxidative activity. Compound 13 was found to pose an antioxidative activity. In addition, this compound was found to extend the life span of  Caenorhabiditis elegans  under standard laboratory conditions and reduces both heat and chemical induced oxidative stress in  C. elegans  in a dose-dependent manner. Furthermore, treatment of worms with compound 13 was found to significantly attenuate the formation of advanced glycation end products and malondialdehyde in a dose-dependent manner.
authors.affiliation: Department of Chemistry, Faculty of Science for Girls, King Abdulaziz University, Jeddah, P.O. Box 50918, Jeddah 21533, Saudi Arabia. rmekh@yahoo.com
authors.forename: Ramadan Ahmed
authors.initials: RA
authors.lastname: Mekheimer
authors.forename: Ahmed Amir Radwan
authors.initials: AA
authors.lastname: Sayed
authors.forename: Eltaib Ali
authors.initials: EA
authors.lastname: Ahmed
mesh_terms: D000367:Age Factors; D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D017173:Caenorhabditis elegans / Q000187:drug effects* / Q000378:metabolism; D017127:Glycation End Products, Advanced / Q000378:metabolism; D053208:Kaplan-Meier Estimate; D009682:Magnetic Resonance Spectroscopy; D008315:Malondialdehyde / Q000378:metabolism; D013058:Mass Spectrometry; D018384:Oxidative Stress / Q000187:drug effects*; D011725:Pyridines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D014230:Triazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D017127:Glycation End Products, Advanced; D011725:Pyridines; D014230:Triazoles; D008315:Malondialdehyde