title: Nanoindentation of osteonal bone lamellae.
abstract: Variations in Young's modulus of individual lamellae around a single bone osteon have been measured in three orthogonal planes by nanoindentation. The objective of these measurements was to establish a correlation between the mechanical properties and the microstructure of the osteonal lamellae. When indentation was performed in a plane perpendicular to the osteon axis (OA), the modulus of the lamella closest to the canal appears to be higher than the modulus of all other lamellae. No such difference was observed in planes parallel to the OA. However, in the parallel planes, an unexpected asymmetry in modulus was detected on opposing sides of the canal, potentially supporting the validity of the rotated plywood structure model of bone lamellae. Finally, based on the experimentally measured Young's modulus values, most osteonal lamellae appear to exhibit structural anisotropy.
authors.affiliation: Department of Materials and Interfaces, Weizmann Institute of Science, Rehovot 76100, Israel.
authors.forename: Anna
authors.initials: A
authors.lastname: Faingold
authors.forename: Sidney R
authors.initials: SR
authors.lastname: Cohen
authors.forename: H Daniel
authors.initials: HD
authors.lastname: Wagner
mesh_terms: D000818:Animals; D016880:Anisotropy; D001672:Biocompatible Materials / Q000737:chemistry*; D001696:Biomechanical Phenomena; D018786:Bone Substitutes / Q000737:chemistry*; D001842:Bone and Bones / Q000502:physiology; D055119:Elastic Modulus; D005269:Femur / Q000033:anatomy & histology* / Q000473:pathology; D006253:Haversian System / Q000033:anatomy & histology / Q000502:physiology*; D006736:Horses; D006801:Humans; D021621:Imaging, Three-Dimensional / Q000379:methods; D007477:Ions; D008297:Male; D008422:Materials Testing; D018625:Microscopy, Atomic Force; D008962:Models, Theoretical; D036103:Nanotechnology / Q000379:methods; D013314:Stress, Mechanical
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D007477:Ions