title: Extravasation of liposomal doxorubicin induces irritant reaction without vesicant injury.
abstract: Anthracycline extravasation is an uncommon but very serious complication. Very few data are available in the literature concerning the consequences and the management of extravasation of liposomal doxorubicin. This report describes the cases of two patients with liposomal doxorubicin extravasation who developed irritant reaction without vesicant or necrotic lesions. It is concordant with other cases described in the literature and suggests that extravasation of liposomal doxorubicin can be relatively well tolerated. The process applied to extravasations of irritant and non-vesicant agents could be used to manage extravasations of liposomal doxorubicin.
authors.affiliation: University of Franche Comté, Besançon, France. elsa.curtit7@wanadoo.fr
authors.forename: Elsa
authors.initials: E
authors.lastname: Curtit
authors.forename: Loïc
authors.initials: L
authors.lastname: Chaigneau
authors.forename: Julien
authors.initials: J
authors.lastname: Pauchot
authors.forename: Thierry
authors.initials: T
authors.lastname: Nguyen
authors.forename: Virginie
authors.initials: V
authors.lastname: Nerich
authors.forename: Fernando
authors.initials: F
authors.lastname: Bazan
authors.forename: Antoine
authors.initials: A
authors.lastname: Thiery-Vuillemin
authors.forename: Martin
authors.initials: M
authors.lastname: Demarchi
authors.forename: Xavier
authors.initials: X
authors.lastname: Pivot
authors.forename: Cristian
authors.initials: C
authors.lastname: Villanueva
mesh_terms: D000368:Aged; D004317:Doxorubicin / Q000009:adverse effects*; D005119:Extravasation of Diagnostic and Therapeutic Materials; D005260:Female; D006801:Humans; D007509:Irritants / Q000009:adverse effects*; D008875:Middle Aged
chemical_list: D007509:Irritants; D004317:Doxorubicin