title: Olive oil supplemented with Coenzyme Q(10): effect on plasma and lipoprotein oxidative status.
abstract: Olive oil consumption is associated with protective cardiovascular properties, including some beneficial modifications in lipoprotein profile and composition. Coenzyme Q(10) (CoQ(10)) exerts a protective effect on plasma lipoproteins. Aim of the study was to investigate whether extra virgin (EV) olive oil enriched with CoQ(10) affects CoQ(10) levels and oxidative status in plasma and in isolated lipoproteins. Twelve subjects were administered 20 mL olive oil per day for 2 weeks, followed by 2 weeks of olive oil enriched with 20 mg and 2 more weeks with 40 mg of CoQ(10). Plasma and isolated lipoproteins were collected in each phase of the study and subsequently analyzed to assess lipid profile, CoQ10 levels, ORAC assay, resistance of lipoproteins to peroxidation and paroxonase 1 activity. Plasma CoQ(10) levels significantly increased with the 20 mg (+73%) and 40 mg dose (+170%), while the percentage of oxidized CoQ(10) decreased. A significant inverse correlation was found in plasma between percentage of oxidized CoQ(10) and total antioxidant capacity. A lower susceptibility of LDL to peroxidation was also found. Finally, a positive correlation was observed between concentration of CoQ(10) in HDL and paraoxonase-1 activity. EV olive oil enriched with both doses of CoQ(10) significantly affects its bioavailability and plasma redox status. These changes are associated with a decreased susceptibility of plasma lipoproteins to peroxidation associated with a chain-breaking antioxidant activity of the formulation.
authors.affiliation: Department of Clinical and Dental Sciences, Polytechnic University of Marche, Ancona, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Brugè
authors.forename: Tiziana
authors.initials: T
authors.lastname: Bacchetti
authors.forename: Federica
authors.initials: F
authors.lastname: Principi
authors.forename: Emanuele-Salvatore
authors.initials: ES
authors.lastname: Scarpa
authors.forename: Gian Paolo
authors.initials: GP
authors.lastname: Littarru
authors.forename: Luca
authors.initials: L
authors.lastname: Tiano
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism; D043303:Aryldialkylphosphatase / Q000378:metabolism; D008078:Cholesterol, LDL / Q000097:blood* / Q000378:metabolism; D019587:Dietary Supplements; D006801:Humans; D015227:Lipid Peroxidation; D008077:Lipoproteins, LDL / Q000097:blood*; D000069463:Olive Oil; D018384:Oxidative Stress; D010938:Plant Oils / Q000008:administration & dosage*; D014451:Ubiquinone / Q000008:administration & dosage / Q000031:analogs & derivatives*
chemical_list: D000975:Antioxidants; D008078:Cholesterol, LDL; D008077:Lipoproteins, LDL; D000069463:Olive Oil; D010938:Plant Oils; D014451:Ubiquinone; D043303:Aryldialkylphosphatase; C024989:coenzyme Q10