title: Recognition of sialylated poly-N-acetyllactosamine chains on N- and O-linked glycans by human and avian influenza A virus hemagglutinins.
abstract: Human influenza viruses are proposed to recognize sialic acids (pink diamonds) on glycans extended with poly-LacNAc chains (LacNAc=(yellow circle+blue square)). N- and O-linked glycans were extended with different poly-LacNAc chains with α2-3- and α2-6-linked sialic acids recognized by human and avian influenza viruses, respectively. The specificity of recombinant hemagglutinins (receptors in green) was investigated by using glycan microarray technology.
authors.affiliation: Department of Chemical Physiology, The Scripps Research Institute, La Jolla, CA 92037, USA.
authors.forename: Corwin M
authors.initials: CM
authors.lastname: Nycholat
authors.forename: Ryan
authors.initials: R
authors.lastname: McBride
authors.forename: Damian C
authors.initials: DC
authors.lastname: Ekiert
authors.forename: Rui
authors.initials: R
authors.lastname: Xu
authors.forename: Janani
authors.initials: J
authors.lastname: Rangarajan
authors.forename: Wenjie
authors.initials: W
authors.lastname: Peng
authors.forename: Nahid
authors.initials: N
authors.lastname: Razi
authors.forename: Michel
authors.initials: M
authors.lastname: Gilbert
authors.forename: Warren
authors.initials: W
authors.lastname: Wakarchuk
authors.forename: Ian A
authors.initials: IA
authors.lastname: Wilson
authors.forename: James C
authors.initials: JC
authors.lastname: Paulson
mesh_terms: D000818:Animals; D001717:Birds; D002240:Carbohydrate Sequence; D006388:Hemagglutinins / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D009980:Influenza A virus / Q000737:chemistry / Q000378:metabolism*; D005585:Influenza in Birds / Q000821:virology*; D007251:Influenza, Human / Q000821:virology*; D046228:Microarray Analysis; D008969:Molecular Sequence Data; D011134:Polysaccharides / Q000737:chemistry / Q000378:metabolism*; D012794:Sialic Acids / Q000737:chemistry / Q000378:metabolism*
chemical_list: D006388:Hemagglutinins; D011134:Polysaccharides; D012794:Sialic Acids; C037199:poly-N-acetyllactosamine