title: Borax counteracts genotoxicity of aluminum in rat liver.
abstract: This study was carried out to evaluate the protective role of borax (BX) on genotoxicity induced by aluminum (Al) in rat liver, using liver micronucleus assay as an indicator of genotoxicity. Sprague-Dawley rats were randomly separated into six groups and each group had four animals. Aluminum chloride (AlCl₃; 5 mg/kg b.w.) and BX (3.25 and 13 mg/kg b.w.) were injected intraperitoneally to rats. Besides, animals were also treated with Al for 4 consecutive days followed by BX for 10 days. Rats were anesthetized after Al and BX injections and the hepatocytes were isolated for counting the number of micronucleated hepatocytes (MNHEPs). AlCl₃ was found to significantly (p < 0.05) increase the number of MNHEPs. Rats treated with BX, however, showed no increase in MNHEPs. Moreover, simultaneous treatments with BX significantly modulated the genotoxic effects of AlCl₃ in rats. It can be concluded that BX has beneficial influences and has the ability to antagonize Al toxicity.
authors.affiliation: 1Department of Molecular Biology and Genetics, Erzurum Technical University, Erzurum, Turkey.
authors.forename: Hasan
authors.initials: H
authors.lastname: Turkez
authors.forename: Fatime
authors.initials: F
authors.lastname: Geyikoğlu
authors.forename: Abdulgani
authors.initials: A
authors.lastname: Tatar
mesh_terms: D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000633:toxicity*; D000818:Animals; D001881:Borates / Q000494:pharmacology*; D002712:Chlorides / Q000633:toxicity*; D004249:DNA Damage / Q000187:drug effects*; D022781:Hepatocytes / Q000187:drug effects; D008099:Liver / Q000187:drug effects*; D008297:Male; D015162:Micronucleus Tests; D009153:Mutagens / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D017607:Aluminum Compounds; D001881:Borates; D002712:Chlorides; D009153:Mutagens; C018851:borax; D000077410:Aluminum Chloride