title: Use of a multicomponent reaction for chemoselective derivatization of multiple classes of metabolites.
abstract: We demonstrate that the Ugi reaction enables chemoselective derivatization of biological amines, carboxylic acids, aldehydes, or ketones with a chromophore under one set of reaction conditions, even in the presence of water. Derivatization of neurotransmitters, hormones, disease biomarkers and other metabolites bodes well for systems biology and diagnostic medicine.
authors.affiliation: Chemistry Department, Brown University, 324 Brook Street, Providence, RI 02914, USA.
authors.forename: Kyle A
authors.initials: KA
authors.lastname: Totaro
authors.forename: Babajide O
authors.initials: BO
authors.lastname: Okandeji
authors.forename: Jason K
authors.initials: JK
authors.lastname: Sello
mesh_terms: D000596:Amino Acids / Q000737:chemistry / Q000378:metabolism*; D015415:Biomarkers / Q000737:chemistry*; D003486:Cyanides / Q000737:chemistry / Q000378:metabolism*; D055432:Metabolomics / Q000379:methods*
chemical_list: D000596:Amino Acids; D015415:Biomarkers; D003486:Cyanides