title: Enhanced visualization of biodegradable polymeric vascular scaffolds by incorporation of gold, silver and magnetite nanoparticles.
abstract: Due to improved tissue regeneration and the enabling of post-operative minimally invasive interventions in the same vessel segment, biodegradable polymeric scaffolds represent a competitive approach to permanent metallic stents in vascular applications. Despite these advantages some challenges, such as the improvement of the scaffold mechanics and enhancement of scaffold visibility during the implantation procedure, are persisting. Therefore, the scope of our studies was to investigate the potential of gold, silver and magnetite nanoparticles incorporated in a polymeric blend of poly(L-lactide)/poly(4-hydroxybutyrate) for image enhancement in X-ray, magnetic resonance or near-infrared imaging. Their impact on mechanical properties of such modified scaffold materials was also evaluated.
authors.affiliation: Institute for Biomedical Engineering, University of Rostock, Rostock, Germany. frank.luderer@uni-rostock.de
authors.forename: Frank
authors.initials: F
authors.lastname: Luderer
authors.forename: Ivonne
authors.initials: I
authors.lastname: Begerow
authors.forename: Wolfram
authors.initials: W
authors.lastname: Schmidt
authors.forename: Heiner
authors.initials: H
authors.lastname: Martin
authors.forename: Niels
authors.initials: N
authors.lastname: Grabow
authors.forename: Carsten M
authors.initials: CM
authors.lastname: Bünger
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Schareck
authors.forename: Klaus-Peter
authors.initials: KP
authors.lastname: Schmitz
authors.forename: Katrin
authors.initials: K
authors.lastname: Sternberg
mesh_terms: D020341:Absorbable Implants; D001807:Blood Vessel Prosthesis; D006046:Gold / Q000032:analysis*; D008279:Magnetic Resonance Imaging; D058185:Magnetite Nanoparticles / Q000032:analysis* / Q000648:ultrastructure; D008422:Materials Testing; D053758:Nanoparticles / Q000032:analysis* / Q000648:ultrastructure; D011091:Polyesters / Q000032:analysis*; D012834:Silver / Q000032:analysis*; D019265:Spectroscopy, Near-Infrared; D055114:X-Ray Microtomography
chemical_list: D058185:Magnetite Nanoparticles; D011091:Polyesters; C107955:poly(4-hydroxybutanoate); D012834:Silver; C033616:poly(lactide); D006046:Gold