title: [Association between tartrate-resistant acid phosphatase 5 gene polymorphism and adolescent idiopathic scoliosis].
abstract: OBJECTIVE
  To investigate whether the titrate-resistant acid phosphatase 5 (ACP5) gene polymorphisms were associated with the occurrence or curve severity of adolescent idiopathic scoliosis (AIS).
  
  
  METHODS
  There were 372 AIS patients from January 2006 to December 2008 and 239 normal controls from March 2005 to August 2006 were recruited. The Cobb angles were ≥ 10° in all AIS patients. Using the haplotype data of Han population from the Hapmap Project, two tag SNPs (rs2229531, rs2071484) were defined for ACP5 gene. PCR-restriction fragment length polymorphism was used for the genotyping.
  
  
  RESULTS
  No polymorphism in rs2229531 was found in this study. The genotype and allele frequency distribution in rs2071484 were similar between AIS patients and normal controls (χ(2) = 3.336 and 1.438, P > 0.05). The mean maximum Cobb angles of different genotypes of rs2071484 in ACP5 gene were 38° ± 19° in AA, 34° ± 14° in AG and 38° ± 21° in GG, which were similar with each other among AIS patients who reached skeletal maturity or received surgery treatment (P = 0.157).
  
  
  CONCLUSIONS
  The ACP5 gene is neither associated with the occurrence nor the curve severity of AIS.
authors.affiliation: Department of Orthopedics Surgery, the Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing 210008, China.
authors.forename: Qing-hua
authors.initials: QH
authors.lastname: Zhao
authors.forename: Ze-zhang
authors.initials: ZZ
authors.lastname: Zhu
authors.forename: Yong
authors.initials: Y
authors.lastname: Qiu
authors.forename: Bin
authors.initials: B
authors.lastname: Wang
authors.forename: Bang-ping
authors.initials: BP
authors.lastname: Qian
authors.forename: Jun
authors.initials: J
authors.lastname: Jiang
authors.forename: Sai-Hu
authors.initials: SH
authors.lastname: Mao
mesh_terms: D000135:Acid Phosphatase / Q000235:genetics*; D000293:Adolescent; D002648:Child; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic; D012600:Scoliosis / Q000235:genetics*; D000071681:Tartrate-Resistant Acid Phosphatase
chemical_list: D007527:Isoenzymes; C000605510:ACP5 protein, human; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase