title: Cellular antioxidant activity of feijoada whole meal coupled with an in vitro digestion.
abstract: Consumption of plant food rich meals, such as feijoada, a traditional meal in Brazil, is associated with the reduction of chronic disease. The objectives of this study were to determine phytochemical content and antioxidant activity by chemical and cellular antioxidant assays (CAA) of feijoada with or without in vitro digestion. Feijoada showed no difference in phenolics and flavonoids after digestion. Bound and residue contributions to total phenolics were 20.9% and 32.2%, respectively, suggesting that phenolics reach the colon after intake. Flavonoids in residue and bound fractions represented 50% of total flavonoids. Antioxidant activity of feijoada without digestion was higher than that with digestion; however, it showed lower antiproliferative activity and CAA. Feijoada with in vitro digestion also yielded phenolics with higher CAA. Analyses of whole meals should be used to evaluate phytochemicals present in food mixtures consumed, especially with digestion models coupled with CAA resulting in information similar to those in physiological conditions.
authors.affiliation: Federal University of Rio de Janeiro, Avenida Carlos Chagas Filho, 393 RJ 21941-590, Brazil.
authors.forename: Ana Luisa Kremer
authors.initials: AL
authors.lastname: Faller
authors.forename: Eliane
authors.initials: E
authors.lastname: Fialho
authors.forename: Rui Hai
authors.initials: RH
authors.lastname: Liu
mesh_terms: D000975:Antioxidants / Q000737:chemistry* / Q000494:pharmacology; D001938:Brazil; D049109:Cell Proliferation / Q000187:drug effects; D002477:Cells / Q000187:drug effects* / Q000378:metabolism; D014676:Diet, Vegetarian; D004063:Digestion; D002523:Edible Grain / Q000737:chemistry*; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology; D056945:Hep G2 Cells; D006801:Humans; D008954:Models, Biological; D010084:Oxidation-Reduction; D010636:Phenols / Q000737:chemistry / Q000494:pharmacology; D010936:Plant Extracts / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D005419:Flavonoids; D010636:Phenols; D010936:Plant Extracts