title: Reduced expression of Sytl 1 and Ccdc21 and impaired induction of Mt I by oxidative stress in SII-K1 knockout mice.
abstract: SII-K1 is a member of the transcription elongation factor S-II family. In the mouse, SII-K1 is expressed exclusively in the liver, kidney, heart, and skeletal muscle. Here, we report that deletion of the SII-K1 gene in mice resulted in the downregulation of the synaptotagmin-like 1 (Sytl 1) gene in liver and of the coiled-coil domain-containing 21 (Ccdc21) gene in liver and kidney. Moreover, the induction of the metallothionein I (Mt I) gene in SII-K1-deficient mice liver was impaired in diethyl maleate-induced oxidative stress conditions. Our results suggest that SII-K1 regulates these genes in vivo.
authors.affiliation: Radioisotope Center, The University of Tokyo, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Tano
authors.forename: H
authors.initials: H
authors.lastname: Hamamoto
authors.forename: T
authors.initials: T
authors.lastname: Ito
authors.forename: E
authors.initials: E
authors.lastname: Sumiya
authors.forename: R
authors.initials: R
authors.lastname: Rakwal
authors.forename: J
authors.initials: J
authors.lastname: Shibato
authors.forename: Y
authors.initials: Y
authors.lastname: Masuo
authors.forename: K
authors.initials: K
authors.lastname: Ijiri
authors.forename: K
authors.initials: K
authors.lastname: Sekimizu
authors.forename: N
authors.initials: N
authors.lastname: Akimitsu
mesh_terms: D000818:Animals; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008668:Metallothionein; D051379:Mice; D018345:Mice, Knockout; D018384:Oxidative Stress
chemical_list: D008668:Metallothionein