title: Connective tissue diseases. Unravelling aetiology in male SLE--the X chromosome dose effect.
abstract: New evidence suggesting an X chromosome effect underlies the development and progression of male systemic lupus erythematosus comes from a study of sex chromosome aneuploidy in men with this disease. The description of a number of immunoregulatory mechanisms encoded on the X chromosome support this hypothesis; however, further studies are warranted.
authors.affiliation: Department of Medicine C, Wolfson Medical Center, 61 Halochamim Street, Holon, Israel. goddard@wolfson.health.gov.il
authors.forename: Gisele
authors.initials: G
authors.lastname: Zandman-Goddard
authors.forename: Elena
authors.initials: E
authors.lastname: Peeva
mesh_terms: D000782:Aneuploidy; D041321:Chromosomes, Human, X; D005260:Female; D018628:Gene Dosage; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D008297:Male; D012737:Sex Factors