title: In vitro corrosion behavior and in vivo biodegradation of biomedical β-Ca3(PO4)2/Mg-Zn composites.
abstract: In this study 5, 10 and 15% β-Ca(3)(PO(4))(2)/Mg-Zn composites were prepared through powder metallurgy methods, and their corrosion behavior and mechanical properties were studied in simulated body fluid (SBF) at 37°C. The 10% β-Ca(3)(PO(4))(2)/Mg-Zn composite was selected for cytocompatibility assessment and in vivo biodegradation testing. The results identified the α-Mg, MgZn and β-Ca(3)(PO(4))(2) phases in these sintered composites. The density and elastic modulus of the β-Ca(3)(PO(4))(2)/Mg-6% Zn composite match those of natural bone, and the strength is approximately double that of natural bone. The 10% β-Ca(3)(PO(4))(2)/Mg-6% Zn composites exhibit good corrosion resistance, as determined by a 30 day immersion test and electrochemical measurements in SBF at 37°C. The 10% β-Ca(3)(PO(4))(2)/Mg-6% Zn composite is safe for cellular applications, with a cytotoxicity grade of ∼0-1 against L929 cells in in vitro testing. The β-Ca(3)(PO(4))(2)/Mg-6% Zn composite also exhibits good biocompatibility with the tissue and the important visceral organs the heart, kidney and liver of experimental rabbits. The composite has a suitable degradation rate and improves the concrescence of a pre-broken bone. The corrosion products, such as Mg(OH)(2) and Ca(5)(PO(4))(6)(OH)(2), can improve the biocompatibility of the β-Ca(3)(PO(4))(2)/Mg-Zn composite.
authors.affiliation: School of Materials Science and Engineering, Central South University, Changsha, People's Republic of China.
authors.forename: Kun
authors.initials: K
authors.lastname: Yu
authors.forename: Liangjian
authors.initials: L
authors.lastname: Chen
authors.forename: Jun
authors.initials: J
authors.lastname: Zhao
authors.forename: Shaojun
authors.initials: S
authors.lastname: Li
authors.forename: Yilong
authors.initials: Y
authors.lastname: Dai
authors.forename: Qiao
authors.initials: Q
authors.lastname: Huang
authors.forename: Zhiming
authors.initials: Z
authors.lastname: Yu
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology*; D001826:Body Fluids / Q000187:drug effects; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000187:drug effects / Q000601:surgery; D002130:Calcium Phosphates / Q000494:pharmacology*; D002460:Cell Line; D003343:Corrosion; D006859:Hydrogen / Q000032:analysis; D006863:Hydrogen-Ion Concentration / Q000187:drug effects; D008274:Magnesium / Q000097:blood / Q000494:pharmacology*; D008297:Male; D008422:Materials Testing / Q000379:methods*; D055595:Mechanical Phenomena / Q000187:drug effects; D009928:Organ Specificity / Q000187:drug effects; D019919:Prosthesis Implantation; D011817:Rabbits; D054457:Tissue Scaffolds / Q000737:chemistry*; D055114:X-Ray Microtomography; D015032:Zinc / Q000097:blood / Q000494:pharmacology*
chemical_list: D001672:Biocompatible Materials; D002130:Calcium Phosphates; D006859:Hydrogen; D008274:Magnesium; D015032:Zinc; C018392:tricalcium phosphate