title: Nickel-catalyzed C-H direct amination of benzoxazoles with secondary amines.
abstract: In this article, a facile, efficient and practical method for Ni-catalyzed direct C-H amination of benzoxazole with secondary amines has been developed. This procedure requires Ni(OAc)(2)·4H(2)O as catalyst, TBHP as oxidant and acid as the additive. A variety of substituted benzoxazol-2-amines were synthesized in moderate to good yields.
authors.affiliation: State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, Dalian, PR China. ymli@dlut.edu.cn
authors.forename: Yaming
authors.initials: Y
authors.lastname: Li
authors.forename: Jin
authors.initials: J
authors.lastname: Liu
authors.forename: Yusheng
authors.initials: Y
authors.lastname: Xie
authors.forename: Rong
authors.initials: R
authors.lastname: Zhang
authors.forename: Kun
authors.initials: K
authors.lastname: Jin
authors.forename: Xiuna
authors.initials: X
authors.lastname: Wang
authors.forename: Chunying
authors.initials: C
authors.lastname: Duan
mesh_terms: D000586:Amination; D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry*; D001583:Benzoxazoles / Q000138:chemical synthesis / Q000737:chemistry*; D002384:Catalysis; D015394:Molecular Structure; D009532:Nickel / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000588:Amines; D001583:Benzoxazoles; D009532:Nickel