title: Increased epicardial adipose tissue in patients with isolated coronary artery ectasia.
abstract: BACKGROUND
  Epicardial adipose tissue (EAT), localized beneath the visceral pericardium, is a metabolically active endocrine and paracrine organ with possible interactions within the heart. Coronary artery ectasia (CAE) is a clinical entity characterized with localized or diffuse dilatation, of the coronary arteries, with a diameter of greater than 1.5 times that of adjacent segments. Although the etiopathogenesis is not clearly understood, some studies have revealed that CAE may be a form of atherosclerosis that has greater inflammatory properties than atherosclerosis. The goal of this study was to investigate whether EAT and the level of C-reactive protein (CRP) are increased in patients with isolated CAE compared to normal subjects.
  
  
  METHODS
  Thirty-three patients with isolated CAE (mean age: 57±9 years) and 32 age- and gender-matched control participants with NCA, but without CAE (mean age: 56±10 years), were included in the study. The relationship between EAT thickness, CRP levels and the presence of CAE was investigated.
  
  
  RESULTS
  Epicardial adipose tissue thickness was significantly higher in CAE group compared to NCA group (7.2±3.2 vs. 4.7±2.1 mm, p<0.001). Body mass index (BMI, p=0.013), CRP (p=0.047), and the percentage of isolated CAE (p=0.012) were significantly higher in patients with an increased EAT thickness. While CRP correlated with increased EAT, it was not related to CAE. However, CRP levels were higher in patients with diffuse coronary ectatic involvement than the focal lesions (0.58±0.32 vs. 0.31±0.11 mg/dL, p=0.046). When we performed multiple logistic regression analysis, only increased EAT thickness was related to CAE independent of CRP and BMI (OR: 1.442, 95%CI: 1.066-1.951, p=0.018).
  
  
  CONCLUSIONS
  This is the first study, displaying a significantly higher EAT-thickness in patients with isolated CAE. We believe that further studies are needed to clarify the role of adipose tissue in patients with isolated CAE.
authors.affiliation: Department of Cardiology, Rize Education and Research Hospital, Turkey.
authors.forename: Mustafa
authors.initials: M
authors.lastname: Çetin
authors.forename: Turan
authors.initials: T
authors.lastname: Erdoğan
authors.forename: Sinan Altan
authors.initials: SA
authors.lastname: Kocaman
authors.forename: Aytun
authors.initials: A
authors.lastname: Çanga
authors.forename: Yüksel
authors.initials: Y
authors.lastname: Çiçek
authors.forename: Murtaza Emre
authors.initials: ME
authors.lastname: Durakoğlugil
authors.forename: Ömer
authors.initials: Ö
authors.lastname: Şatıroğlu
authors.forename: Özgür
authors.initials: Ö
authors.lastname: Akgül
authors.forename: Mehmet
authors.initials: M
authors.lastname: Bostan
mesh_terms: D000273:Adipose Tissue / Q000000981:diagnostic imaging* / Q000378:metabolism; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D003324:Coronary Artery Disease / Q000097:blood / Q000000981:diagnostic imaging*; D003430:Cross-Sectional Studies; D004108:Dilatation, Pathologic / Q000097:blood / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010496:Pericardium / Q000000981:diagnostic imaging* / Q000378:metabolism; D014463:Ultrasonography
chemical_list: D015415:Biomarkers; D002097:C-Reactive Protein