title: AMPK activation with glabridin ameliorates adiposity and lipid dysregulation in obesity.
abstract: In this study, we demonstrate that activation of AMP-activated protein kinase (AMPK) with glabridin alleviates adiposity and hyperlipidemia in obesity. In several obese rodent models, glabridin decreased body weight and adiposity with a concomitant reduction in fat cell size. Further, glabridin ameliorated fatty liver and plasma levels of triglyceride and cholesterol. In accordance with these findings, glabridin suppressed the expression of lipogenic genes such as sterol regulatory element binding transcription factor (SREBP)-1c, fatty acid synthase (FAS), acetyl-CoA carboxylase (ACC), and stearoyl-CoA desaturase (SCD)-1 in white adipose tissues and liver, whereas it elevated the expression of fatty acid oxidation genes such as carnitine palmitoyl transferase (CPT)1, acyl-CoA oxidase (ACO), and peroxisome proliferator-activated receptor (PPAR)α in muscle. Moreover, glabridin enhanced phosphorylation of AMPK in muscle and liver and promoted fatty acid oxidation by modulating mitochondrial activity. Together, these data suggest that glabridin is a novel AMPK activator that would exert therapeutic effects in obesity-related metabolic disorders.
authors.affiliation: Department of Biophysics and Chemical Biology, School of Biological Sciences, Institute of Molecular Biology & Genetics, Seoul National University, Seoul 151-742, Korea.
authors.forename: Joo-Won
authors.initials: JW
authors.lastname: Lee
authors.forename: Sung Sik
authors.initials: SS
authors.lastname: Choe
authors.forename: Hagoon
authors.initials: H
authors.lastname: Jang
authors.forename: Jiyeong
authors.initials: J
authors.lastname: Kim
authors.forename: Hyun Woo
authors.initials: HW
authors.lastname: Jeong
authors.forename: Hyunsun
authors.initials: H
authors.lastname: Jo
authors.forename: Kyeong-Hoon
authors.initials: KH
authors.lastname: Jeong
authors.forename: Surendar
authors.initials: S
authors.lastname: Tadi
authors.forename: Myoung Gyu
authors.initials: MG
authors.lastname: Park
authors.forename: Tae Hwan
authors.initials: TH
authors.lastname: Kwak
authors.forename: Jin
authors.initials: J
authors.lastname: Man Kim
authors.forename: Dong-Hoon
authors.initials: DH
authors.lastname: Hyun
authors.forename: Jae Bum
authors.initials: JB
authors.lastname: Kim
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000378:metabolism*; D050154:Adiposity / Q000187:drug effects*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005227:Fatty Acids / Q000378:metabolism; D007529:Isoflavones / Q000494:pharmacology*; D050356:Lipid Metabolism / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D009765:Obesity / Q000188:drug therapy* / Q000378:metabolism; D010636:Phenols / Q000494:pharmacology*; D010766:Phosphorylation / Q000187:drug effects
chemical_list: D005227:Fatty Acids; D007529:Isoflavones; D010636:Phenols; D055372:AMP-Activated Protein Kinases; C107601:glabridin