title: Ribosomal therapy in patients with pharyngolaryngeal reflux.
abstract: CONCLUSIONS
  Our data confirm the induction of specific and nonspecific immune responses of the upper respiratory tract mucosa and the consequent improvement of its physiology, through an oral ribosomal therapy in patients with pharyngolaryngeal reflux disease (PLRD).
  
  
  OBJECTIVE
  The aim of this study was to investigate the efficiency and applicability of oral ribosomal immunotherapy in adult patients with PLRD.
  
  
  METHODS
  One hundred adult patients with PLRD were enrolled. The patients were equally divided, at random, into two groups (A and B): group A patients underwent ribosomal prophylaxis with Immucytal® (one tablet daily, 8 days a month for 3 months), while group B received a placebo (same dosage for the same period). At the beginning, at the end, and 6 months after the beginning of the therapy, all patients underwent medical history, ENT examination, nasal-pharynx-laryngoscopy with optic fiber, plasma levels of immunoglobulins class E, A, G, M, subjective assessment of symptoms on a 10 cm visual analog scale (VAS), reflux symptoms index, and reflux finding score.
  
  
  RESULTS
  At the end and 6 months after the beginning of the treatment, all the patients in group A presented a significant (p < 0.05) improvement of almost all the different items analyzed.
authors.affiliation: ENT Department, University of Genoa, Italy. renzomora@libero.it
authors.forename: Renzo
authors.initials: R
authors.lastname: Mora
authors.forename: Francesco
authors.initials: F
authors.lastname: Mora
authors.forename: Barbara
authors.initials: B
authors.lastname: Crippa
authors.forename: Valentina
authors.initials: V
authors.lastname: Santomauro
authors.forename: Luca
authors.initials: L
authors.lastname: Guastini
authors.forename: Giorgio
authors.initials: G
authors.lastname: Peretti
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000942:Antigens, Bacterial / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D016099:Endoscopy, Gastrointestinal; D050782:Esophageal pH Monitoring; D005260:Female; D005500:Follow-Up Studies; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000276:immunology / Q000517:prevention & control*; D006801:Humans; D007136:Immunoglobulins / Q000097:blood / Q000276:immunology*; D007167:Immunotherapy; D008297:Male; D008875:Middle Aged; D012270:Ribosomes / Q000276:immunology*; D055502:Secondary Prevention; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000276:Adjuvants, Immunologic; D000942:Antigens, Bacterial; D007136:Immunoglobulins; C034206:Ribomunyl