title: Streptocarbazoles A and B, two novel indolocarbazoles from the marine-derived actinomycete strain Streptomyces sp. FMA.
abstract: Streptocarbazoles A (1) and B (2), two novel indolocarbazoles featuring unprecedented cyclic N-glycosidic linkages between 1,3-carbon atoms of the glycosyl moiety and two indole nitrogen atoms of the indolocarbazole core, were isolated from the marine-derived actinomycetes strain Streptomyces sp. FMA. Their structures were established by spectroscopic methods, CD spectra, and ECD quantum mechanical calculations. Compound 1 was cytotoxic on HL-60 and A-549 cell lines and could arrest the cell cycle of Hela cells at the G(2)/M phase.
authors.affiliation: Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, PR China.
authors.forename: Peng
authors.initials: P
authors.lastname: Fu
authors.forename: Chunli
authors.initials: C
authors.lastname: Yang
authors.forename: Yi
authors.initials: Y
authors.lastname: Wang
authors.forename: Peipei
authors.initials: P
authors.lastname: Liu
authors.forename: Yiming
authors.initials: Y
authors.lastname: Ma
authors.forename: Lei
authors.initials: L
authors.lastname: Xu
authors.forename: Mingbo
authors.initials: M
authors.lastname: Su
authors.forename: Kui
authors.initials: K
authors.lastname: Hong
authors.forename: Weiming
authors.initials: W
authors.lastname: Zhu
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002227:Carbazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D007211:Indoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008386:Marine Biology; D015394:Molecular Structure; D013302:Streptomyces / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D002227:Carbazoles; D007211:Indoles; C573449:streptocarbazole A; C573450:streptocarbazole B