title: Spectrofluorimetric study of the interaction of ciprofloxacin with amino acids in aqueous solution following solvatochromic studies.
abstract: Complexation of a fluoroquinolone derivative (ciprofloxacin), L, and some amino acids has been studied using spectrofluorimetric method. Results indicated that ciprofloxacin have a greater tendency to form a 1:1 complex with aspartic acid and arginine than the other tested molecules. The fluorescence of ciprofloxacin exhibits quenching process while it has been titrated with these amino acids. Formation constant values (K(f)) for complex formed between ciprofloxacin and amino acids were also calculated. Thermodynamic parameters such as ΔG°, ΔH° and ΔS° were studied too. Possible reasons for the observed stability sequence were discussed based on the structures proposed for the resulting complexes. Besides the solution studies, solvatochromic properties of the ciprofloxacin are discussed by studying its spectra in a selection of different solvents.
authors.affiliation: Department of Chemistry, Lorestan University, Khorramabad, Iran. Alizadehk@yahoo.com
authors.forename: Kamal
authors.initials: K
authors.lastname: Alizadeh
authors.forename: Mahsa
authors.initials: M
authors.lastname: Mobarrez
authors.forename: Mohammad Reza
authors.initials: MR
authors.lastname: Ganjali
authors.forename: Parviz
authors.initials: P
authors.lastname: Norouzi
authors.forename: Mohammad Javad
authors.initials: MJ
authors.lastname: Chaichi
mesh_terms: D000596:Amino Acids / Q000737:chemistry / Q000378:metabolism*; D002939:Ciprofloxacin / Q000737:chemistry / Q000378:metabolism*; D007700:Kinetics; D012996:Solutions; D012997:Solvents / Q000737:chemistry*; D013050:Spectrometry, Fluorescence / Q000379:methods*; D013696:Temperature; D017186:Titrimetry
chemical_list: D000596:Amino Acids; D012996:Solutions; D012997:Solvents; D002939:Ciprofloxacin