title: Scalable total synthesis of (-)-berkelic acid by using a protecting-group-free strategy.
abstract: Supply chain: the polycyclic core of (-)-berkelic acid (1) was constructed in just one step from very simple starting materials. The total synthesis of 1 involves a seven-step linear sequence. Protection/deprotection steps were avoided and all but the last step were performed on a gram scale. This synthesis could solve the supply problem associated with the exhaustion of the natural source.
authors.affiliation: Instituto Universitario de Química Organometálica "Enrique Moles", Unidad Asociada al C.S.I.C., Universidad de Oviedo, Spain. fjfv@uniovi.es
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Fañanás
authors.forename: Abraham
authors.initials: A
authors.lastname: Mendoza
authors.forename: Tamara
authors.initials: T
authors.lastname: Arto
authors.forename: Baris
authors.initials: B
authors.lastname: Temelli
authors.forename: Félix
authors.initials: F
authors.lastname: Rodríguez
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D018360:Crystallography, X-Ray; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000188:drug therapy; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013237:Stereoisomerism
chemical_list: D000970:Antineoplastic Agents; D013141:Spiro Compounds; C520589:berkelic acid