title: Relationship between high-sensitivity C-reactive protein and risk factors in patients with peripheral arterial disease--a cross-sectional study.
abstract: We investigated whether patients with peripheral arterial disease (PAD) with various serum levels of high-sensitivity C-reactive protein (hsCRP) differ in the frequency of atherosclerotic risk factors. Among 388 patients, hsCRP levels were (1) low, <1 mg/L, in 41 (10.6%) participants; (2) medium, from 1 to 3 mg/L, in 152 (39.2%) participants, and (3) high, >3 mg/L, in 195 (50.2%) individuals. According to multivariate logistic regression analysis, in comparison with patients with hsCRP level ≤3.0 mg/L, those with higher hsCRP levels had more frequently a severe form of PAD (gangrene, P ranged from .045 to <.001; ankle-brachial index ≤.40, P = .059) and had more frequently some of atherosclerotic risk factors (metabolic syndrome, P = .007; hypertension, P = .013; abdominal obesity, P = .007; high levels of uric acid, P = .022; high level of fibrinogen, P < .001; and depression, P = .015).
authors.affiliation: Institute of Hygiene and Medical Ecology, Faculty of Medicine, University of Belgrade, Serbia. milos.maksimovic@mfub.bg.ac.rs
authors.forename: Milos
authors.initials: M
authors.lastname: Maksimovic
authors.forename: Hristina
authors.initials: H
authors.lastname: Vlajinac
authors.forename: Djordje
authors.initials: D
authors.lastname: Radak
authors.forename: Jelena
authors.initials: J
authors.lastname: Marinkovic
authors.forename: Jagoda
authors.initials: J
authors.lastname: Jorga
mesh_terms: D000368:Aged; D050197:Atherosclerosis / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis*; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D058729:Peripheral Arterial Disease / Q000097:blood* / Q000453:epidemiology*
chemical_list: D002097:C-Reactive Protein