title: Phosphine-catalyzed domino reaction for the synthesis of conjugated 2,3-dihydrofurans from allenoates and Nazarov reagents.
abstract: A new domino reaction for Nazarov reagents: An efficient approach was developed for the construction of highly functionalized conjugated 2,3-dihydrofuran skeletons. Nazarov reagents were used for the first time in a phosphine-catalyzed domino reaction and successfully used to construct five-membered ring compounds using alcohol as the solvent. DFT calculations indicate that alcohol is essential for the catalysis of the [1,2]-proton transfer.
authors.affiliation: State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China.
authors.forename: Peizhong
authors.initials: P
authors.lastname: Xie
authors.forename: Wenqing
authors.initials: W
authors.lastname: Lai
authors.forename: Zhishuai
authors.initials: Z
authors.lastname: Geng
authors.forename: You
authors.initials: Y
authors.lastname: Huang
authors.forename: Ruyu
authors.initials: R
authors.lastname: Chen
mesh_terms: D000438:Alcohols / Q000737:chemistry; D002384:Catalysis; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry; D009281:Naphthalenes / Q000138:chemical synthesis / Q000737:chemistry*; D010720:Phosphines / Q000737:chemistry*
chemical_list: D000438:Alcohols; D005663:Furans; D009281:Naphthalenes; D010720:Phosphines; C073812:2,3-dihydrofuran; C044646:phosphine; C110055:allenolic acid