title: [Morphology and etiopathogenesis of the abdominal aortic aneurysm].
abstract: The paper summarizes the latest research on the abdominal aorta aneurysm etiopathogenesis and compares normal aorta morphology with changes in the aortic aneurysm wall. The role of risk factors, especially hemodynamic and genetic, is discussed in detail. Special attention is paid to inflammatory processes including cytokines and matrix degrading proteases that contribute to the development of aneurysm. The role of thrombus and the current results of research into biomarkers indicating the risks and progression of the disease are analysed. Finally, a review of pharmacomodulation of the aortic aneurysm using statins, antibiotics, antihypertensive and nonsteroidal antiinflammatory drugs is presented.
authors.affiliation: Ustav histologie a embryologie Lékarské fakulty UK, Plzen. lada.eberlova@lfp.cuni.cz
authors.forename: Lada
authors.initials: L
authors.lastname: Eberlová
authors.forename: Zbynek
authors.initials: Z
authors.lastname: Tonar
authors.forename: Vera
authors.initials: V
authors.lastname: Krízková
authors.forename: Jitka
authors.initials: J
authors.lastname: Kocová
authors.forename: Marie
authors.initials: M
authors.lastname: Korabecná
authors.forename: Vladislav
authors.initials: V
authors.lastname: Treska
authors.forename: Jirí
authors.initials: J
authors.lastname: Molácek
authors.forename: Karel
authors.initials: K
authors.lastname: Houdek
authors.forename: Ludmila
authors.initials: L
authors.lastname: Boudová
authors.forename: Ondrej
authors.initials: O
authors.lastname: Topolcan
authors.forename: Jindra
authors.initials: J
authors.lastname: Vrzalová
authors.forename: Martin
authors.initials: M
authors.lastname: Pesta
authors.forename: Vlastimil
authors.initials: V
authors.lastname: Kulda
authors.forename: Lukás
authors.initials: L
authors.lastname: Nedorost
authors.forename: Jirí
authors.initials: J
authors.lastname: Valenta
mesh_terms: D001012:Aorta, Abdominal / Q000473:pathology; D017544:Aortic Aneurysm, Abdominal / Q000473:pathology / Q000503:physiopathology* / Q000628:therapy; D018450:Disease Progression; D006801:Humans; D012307:Risk Factors