title: Serum levels of receptors for advanced glycation end products in normal-weight and obese children born small and large for gestational age.
abstract: OBJECTIVE
  To assess potential alterations in soluble and endogenous secretory receptors for advanced glycation end products (sRAGE and esRAGE) in normal-weight (NW) and obese (Ob) children born small (SGA) and large (LGA) compared with appropriate for gestational age (AGA) subjects and to explore if birth weight (BW), insulin resistance (IR), and obesity represent independent risk factors.
  
  
  METHODS
  We categorized 130 prepubertal children into six groups according to BW and obesity and evaluated sRAGE, esRAGE, and homeostasis model assessment of IR.
  
  
  RESULTS
  sRAGE and esRAGE were lower in Ob SGA and LGA children than Ob AGA subjects (all P < 0.05), and in NW SGA and LGA children than NW AGA subjects (all P < 0.05). Interestingly, BW and IR were significantly and independently related to RAGE.
  
  
  CONCLUSIONS
  sRAGE and esRAGE are decreased in SGA and LGA children, and BW and IR seem to play an important role in the reduction of RAGE.
authors.affiliation: Department of Pediatrics, University of Chieti, Chieti, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Chiavaroli
authors.forename: Ebe
authors.initials: E
authors.lastname: D'Adamo
authors.forename: Cosimo
authors.initials: C
authors.lastname: Giannini
authors.forename: Tommaso
authors.initials: T
authors.lastname: de Giorgis
authors.forename: Stefania
authors.initials: S
authors.lastname: De Marco
authors.forename: Francesco
authors.initials: F
authors.lastname: Chiarelli
authors.forename: Angelika
authors.initials: A
authors.lastname: Mohn
mesh_terms: D001724:Birth Weight; D002648:Child; D005260:Female; D005865:Gestational Age; D017127:Glycation End Products, Advanced / Q000097:blood*; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age / Q000097:blood*; D007333:Insulin Resistance; D008297:Male; D009765:Obesity / Q000097:blood*; D012307:Risk Factors
chemical_list: D017127:Glycation End Products, Advanced