title: Gut-central nervous system axis is a target for nutritional therapies.
abstract: Historically, in the 1950s, the chemist Linus Pauling established a relationship between decreased longevity and obesity. At this time, with the advent of studies involving the mechanisms that modulate appetite control, some researchers observed that the hypothalamus is the "appetite centre" and that peripheral tissues have important roles in the modulation of gut inflammatory processes and levels of hormones that control food intake. Likewise, the advances of physiological and molecular mechanisms for patients with obesity, type 2 diabetes mellitus, inflammatory bowel diseases, bariatric surgery and anorexia-associated diseases has been greatly appreciated by nutritionists. Therefore, this review highlights the relationship between the gut-central nervous system axis and targets for nutritional therapies.
authors.affiliation: Department of Internal Medicine, State University of Campinas, Campinas, Brazil. gupimentel@yahoo.com.br
authors.forename: Gustavo D
authors.initials: GD
authors.lastname: Pimentel
authors.forename: Thayana O
authors.initials: TO
authors.lastname: Micheletti
authors.forename: Fernanda
authors.initials: F
authors.lastname: Pace
authors.forename: José C
authors.initials: JC
authors.lastname: Rosa
authors.forename: Ronaldo V T
authors.initials: RV
authors.lastname: Santos
authors.forename: Fabio S
authors.initials: FS
authors.lastname: Lira
mesh_terms: D001069:Appetite Regulation; D050110:Bariatric Surgery; D002490:Central Nervous System / Q000378:metabolism* / Q000382:microbiology; D003924:Diabetes Mellitus, Type 2 / Q000178:diet therapy*; D004032:Diet; D005768:Gastrointestinal Hormones / Q000378:metabolism; D041981:Gastrointestinal Tract / Q000378:metabolism* / Q000382:microbiology; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000178:diet therapy*; D054892:Metagenome; D009765:Obesity / Q000178:diet therapy*; D019518:Postprandial Period
chemical_list: D005768:Gastrointestinal Hormones