title: Electronic effects of linker substitution on Lewis acid catalysis with metal-organic frameworks.
abstract: Functionalized linkers can greatly increase the activity of metal-organic framework (MOF) catalysts with coordinatively unsaturated sites. A clear linear free-energy relationship (LFER) was found between Hammett σ(m)  values of the linker substituents X and the rate k(X)  of a carbonyl-ene reaction. This is the first LFER ever observed for MOF catalysts. A 56-fold increase in rate was found when the substituent is a nitro group.
authors.affiliation: Centre for Surface Chemistry and Catalysis, Katholieke Universiteit Leuven, Belgium.
authors.forename: Frederik
authors.initials: F
authors.lastname: Vermoortele
authors.forename: Matthias
authors.initials: M
authors.lastname: Vandichel
authors.forename: Ben
authors.initials: B
authors.lastname: Van de Voorde
authors.forename: Rob
authors.initials: R
authors.lastname: Ameloot
authors.forename: Michel
authors.initials: M
authors.lastname: Waroquier
authors.forename: Veronique
authors.initials: V
authors.lastname: Van Speybroeck
authors.forename: Dirk E
authors.initials: DE
authors.lastname: De Vos