title: Risk variant of oligodendrocyte lineage transcription factor 2 is associated with reduced white matter integrity.
abstract: The oligodendrocyte lineage transcription factor 2 (OLIG2) regulates the genesis of oligodendrocytes, the brain cells responsible for axonal myelination. Although it has been associated with psychiatric and neurological disorders, the impact of this gene on white matter integrity has never been investigated in humans. Using diffusion tensor imaging, we examined the effect of a single nucleotide polymorphism (rs1059004) in OLIG2 previously associated with reduced gene expression, and with psychiatric disorders on fractional anisotropy in 78 healthy subjects. We found that the risk allele (A) was associated with reduced white matter integrity in the corona radiata bilaterally. This is consistent with evidence that it is a schizophrenia susceptibility gene, and suggests that it may confer increased risk through an effect on neuroanatomical connectivity.
authors.affiliation: Department of Psychosis Studies, Institute of Psychiatry, King's College London, King's Health Partners, London, United Kingdom. diana.prata@kcl.ac.uk
authors.forename: Diana P
authors.initials: DP
authors.lastname: Prata
authors.forename: Richard A
authors.initials: RA
authors.lastname: Kanaan
authors.forename: Gareth J
authors.initials: GJ
authors.lastname: Barker
authors.forename: Sukhwinder
authors.initials: S
authors.lastname: Shergill
authors.forename: James
authors.initials: J
authors.lastname: Woolley
authors.forename: Lyudmila
authors.initials: L
authors.lastname: Georgieva
authors.forename: Marco M
authors.initials: MM
authors.lastname: Picchioni
authors.forename: Eugenia
authors.initials: E
authors.lastname: Kravariti
authors.forename: Muriel
authors.initials: M
authors.lastname: Walshe
authors.forename: Matt
authors.initials: M
authors.lastname: Allin
authors.forename: Timothea
authors.initials: T
authors.lastname: Toulopoulou
authors.forename: Elvira
authors.initials: E
authors.lastname: Bramon
authors.forename: Colm
authors.initials: C
authors.lastname: McDonald
authors.forename: Vincent
authors.initials: V
authors.lastname: Giampietro
authors.forename: Robin M
authors.initials: RM
authors.lastname: Murray
authors.forename: Michael
authors.initials: M
authors.lastname: Brammer
authors.forename: Michael
authors.initials: M
authors.lastname: O'Donovan
authors.forename: Philip
authors.initials: P
authors.lastname: McGuire
mesh_terms: D000293:Adolescent; D000328:Adult; D051792:Basic Helix-Loop-Helix Proteins / Q000235:genetics*; D001921:Brain / Q000166:cytology*; D056324:Diffusion Tensor Imaging; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000648:ultrastructure*; D009419:Nerve Tissue Proteins / Q000235:genetics*; D000076104:Oligodendrocyte Transcription Factor 2; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D012559:Schizophrenia / Q000235:genetics; D055815:Young Adult
chemical_list: D051792:Basic Helix-Loop-Helix Proteins; D009419:Nerve Tissue Proteins; D000076104:Oligodendrocyte Transcription Factor 2; C405708:OLIG2 protein, human