title: A 15-day oral dose toxicity study of aspirin eugenol ester in Wistar rats.
abstract: The subchronic toxicity of aspirin eugenol ester (AEE) was evaluated after 15-day intragastrically administration in rats at daily doses of 50, 1000, and 2000 mg/kg. AEE at low-dose showed no toxicity to the tested rats. Following repeated exposure to medium- or high-dose of AEE, apparent changes were observed in the levels of blood glucose, AST, ALP, ALT and TB in both male and female rats, and appeared to be dose-independent. There were no significant gender differences in most indexes of subchronic toxicity throughout the experimental period with the exception of food consumption and body weight. The no-observed-adverse-effect level (NOAEL) of AEE was considered to be 50 mg/kg/day under the present study conditions.
authors.affiliation: Key Lab of New Animal Drug Project, Gansu Province, Key Lab of Veterinary Pharmaceutical Development, Ministry of Agriculture, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of CAAS, Lanzhou 730050, PR China. lijy1971@163.com
authors.forename: Jianyong
authors.initials: J
authors.lastname: Li
authors.forename: Yuanguang
authors.initials: Y
authors.lastname: Yu
authors.forename: Yajun
authors.initials: Y
authors.lastname: Yang
authors.forename: Xiwang
authors.initials: X
authors.lastname: Liu
authors.forename: Jiyu
authors.initials: J
authors.lastname: Zhang
authors.forename: Bing
authors.initials: B
authors.lastname: Li
authors.forename: Xuzheng
authors.initials: X
authors.lastname: Zhou
authors.forename: Jianrong
authors.initials: J
authors.lastname: Niu
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: Wei
authors.forename: Zhiqi
authors.initials: Z
authors.lastname: Liu
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001241:Aspirin / Q000031:analogs & derivatives* / Q000633:toxicity*; D001663:Bilirubin / Q000097:blood; D001772:Blood Cell Count; D001774:Blood Chemical Analysis; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D004435:Eating; D005054:Eugenol / Q000031:analogs & derivatives* / Q000633:toxicity*; D005260:Female; D007441:Intubation, Gastrointestinal; D008111:Liver Function Tests; D008297:Male; D019055:No-Observed-Adverse-Effect Level; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D016707:Tissue Fixation
chemical_list: D001786:Blood Glucose; C575435:aspirin eugenol ester; D005054:Eugenol; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D001241:Aspirin; D001663:Bilirubin