title: Microwave-assisted one-pot synthesis of isoquinolines, furopyridines, and thienopyridines by palladium-catalyzed sequential coupling-imination-annulation of 2-bromoarylaldehydes with terminal acetylenes and ammonium acetate.
abstract: A palladium-catalyzed microwave-assisted one-pot reaction for the synthesis of isoquinolines is developed. The reaction is carried out by sequential coupling-imination-annulation reactions of ortho-bromoarylaldehydes and terminal alkynes with ammonium acetate, and a variety of substituted isoquinolines, furopyridines, and thienopyridines is prepared in moderate to excellent yields (up to 86%).
authors.affiliation: Department of Chemistry and Biochemistry, Queens College and the Graduate Center of the City University of New York, Flushing, New York 11367, USA.
authors.forename: Dingqiao
authors.initials: D
authors.lastname: Yang
authors.forename: Satvika
authors.initials: S
authors.lastname: Burugupalli
authors.forename: David
authors.initials: D
authors.lastname: Daniel
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
mesh_terms: D000085:Acetates / Q000737:chemistry*; D000114:Acetylene / Q000737:chemistry*; D000447:Aldehydes / Q000737:chemistry*; D000480:Alkynes / Q000737:chemistry*; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry*; D008872:Microwaves; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry*; D058924:Thienopyridines / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D000085:Acetates; D000447:Aldehydes; D000480:Alkynes; D007546:Isoquinolines; D058924:Thienopyridines; D010165:Palladium; D000114:Acetylene; C018824:ammonium acetate