title: Therapeutic effects of calcium & vitamin D supplementation in women with PCOS.
abstract: OBJECTIVE
  To evaluate the efficacy of calcium & vitamin D supplementation in infertile women suffering from polycystic ovary syndrome (PCOS), and to assess levels of 25-hydroxy vitamin D in these patients.
  
  
  METHODS
  In a case control study, 100 infertile PCOS women based on a randomly divided into two groups. Group I (n = 50) were treated with metformin 1500 mg/day, and group II (n = 50) treated with metformin 1500 mg/day plus Calcium 1000 mg/day and Vitamin D 100000 IU/month for 6 months. Patients were followed by transvaginal sonography at first, 3 and 6 months later for evaluating dominant follicle. BMI, menstrual regularity, follicle diameter, pregnancy, serum 25-OH-vitamin D level were matured and compared in two groups.
  
  
  RESULTS
  BMI decreased almost significantly (25.49 ± 1.88 vs 26.28 ± 2.15, p: 0.054) in group II. A better improvement was gained in regulating menstrual abnormalities (70% vs 58%, p: 0.211), follicle maturation (28% vs 22%, p: 0.698), and infertility (18% vs 12%, p: 0.401) in group II compared with group I, but these results were not statistically significant. Eighty three percent of all the PCOS patients showed vitamin D deficiency while 35% were severely deficient. The serum 25-OH-vitamin D mean levels were 13.38 ± 6.48 ng/ml. Vitamin D deficiency was recompensed in 74% of the PCOS patients who had taken calcium & vitamin D supplementation. There was no correlation between BMI and 25-OH-VD before and after the treatment (p ≥ 0.01).
  
  
  CONCLUSIONS
  This study showed the positive effects of calcium & vitamin D supplementation on weight loss, follicle maturation, menstrual regularity, and improvement of hyperandrogenism, in infertile women with PCOS.
authors.affiliation: Research and Clinical Center for Infertility, Shahid Sedughi University of Medical Sciences and Health Services, Yazd, Iran. dr_firouzabadi@ssu.ac.ir
authors.forename: Raziah dehghani
authors.initials: Rd
authors.lastname: Firouzabadi
authors.forename: Abbas
authors.initials: A
authors.lastname: Aflatoonian
authors.forename: Seyedehzalfa
authors.initials: S
authors.lastname: Modarresi
authors.forename: Leila
authors.initials: L
authors.lastname: Sekhavat
authors.forename: Somayeh
authors.initials: S
authors.lastname: MohammadTaheri
mesh_terms: D000328:Adult; D002118:Calcium / Q000008:administration & dosage / Q000627:therapeutic use*; D016022:Case-Control Studies; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D017588:Hyperandrogenism / Q000188:drug therapy / Q000209:etiology; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D008597:Menstrual Cycle / Q000187:drug effects; D008687:Metformin / Q000008:administration & dosage / Q000627:therapeutic use*; D006080:Ovarian Follicle / Q000187:drug effects; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy* / Q000503:physiopathology; D016896:Treatment Outcome; D014807:Vitamin D / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000097:blood / Q000627:therapeutic use*; D014808:Vitamin D Deficiency / Q000188:drug therapy / Q000209:etiology; D015431:Weight Loss / Q000187:drug effects; D055815:Young Adult
chemical_list: D007004:Hypoglycemic Agents; D014807:Vitamin D; D008687:Metformin; C104450:25-hydroxyvitamin D; D002118:Calcium