title: Cytotoxic activity of some glycoconjugates including saponins and anthracyclines.
abstract: Many different glycoconjugates, including saponins (e.g., hellebrin) and anthracyclines (e.g., doxorubicin), are known to display cytotoxic activities. In recent work, we have developed synthetic protocols for the synthesis of various glycoconjugates, focusing on glycosylation methods for different classes of biomolecules. Simultaneously a number of saponins and anthracyclines have been generated. In this note, the cytotoxic activities of these synthesized compounds are briefly addressed.
authors.affiliation: Laboratory of Organic Chemistry, Åbo Akademi University, FI-20500 Åbo, Finland.
authors.forename: Filip S
authors.initials: FS
authors.lastname: Ekholm
authors.forename: Ágnes
authors.initials: Á
authors.lastname: Berényi
authors.forename: Lucas
authors.initials: L
authors.lastname: Lagerquist
authors.forename: Tiina
authors.initials: T
authors.lastname: Saloranta
authors.forename: István
authors.initials: I
authors.lastname: Zupkó
authors.forename: Gyula
authors.initials: G
authors.lastname: Schneider
authors.forename: János
authors.initials: J
authors.lastname: Wölfling
authors.forename: Reko
authors.initials: R
authors.lastname: Leino
mesh_terms: D018943:Anthracyclines / Q000138:chemical synthesis / Q000494:pharmacology*; D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation; D002470:Cell Survival; D004317:Doxorubicin / Q000138:chemical synthesis / Q000494:pharmacology*; D005260:Female; D006001:Glycoconjugates / Q000138:chemical synthesis / Q000494:pharmacology*; D006801:Humans; D020128:Inhibitory Concentration 50; D012503:Saponins / Q000138:chemical synthesis / Q000494:pharmacology*; D013256:Steroids / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; D006001:Glycoconjugates; D012503:Saponins; D013256:Steroids; D004317:Doxorubicin