title: Will the real aging Sirtuin please stand up?
abstract: Initial studies linking Sirtuins to longevity in yeast initiated what is now a rich vein of aging research that is full of promise and fraught with controversy. Missing was a demonstration that enhanced Sirtuin expression extends lifespan in mammals. Now Kanfi et al. provide the evidence but with an interesting plot twist - the lesser known SIRT6 is the longevity factor.
authors.affiliation: Buck Institute for Research on Aging, 8001 Redwood Blvd., Novato, CA 94945, USA.
authors.forename: Chen-Yu
authors.initials: CY
authors.lastname: Liao
authors.forename: Brian K
authors.initials: BK
authors.lastname: Kennedy
mesh_terms: D000375:Aging; D000818:Animals; D004249:DNA Damage; D005260:Female; D018507:Gene Expression Regulation, Developmental; D042822:Genomic Instability; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D010641:Phenotype; D011371:Progeria / Q000235:genetics / Q000378:metabolism; D012737:Sex Factors; D056564:Sirtuin 1 / Q000235:genetics / Q000378:metabolism; D037761:Sirtuins / Q000235:genetics / Q000378:metabolism*
chemical_list: C501860:Sirt6 protein, mouse; C470545:Sirt1 protein, mouse; D056564:Sirtuin 1; D037761:Sirtuins