title: Lowering serum uric acid to prevent acute kidney injury.
abstract: Epidemiological, experimental and clinical studies support a role for uric acid in acute kidney injury (AKI). We discuss how the conventional role of uric acid in AKI has now evolved from intratubular crystal deposition to pro-inflammatory, anti-angiogenic and immunological function. Data from recent studies are presented to support the hypothesis that uric acid may have a role in AKI via a crystal-independent process in addition to its traditionally accepted role to induce injury via crystal-dependent pathways.
authors.affiliation: Division of Nephrology, Hypertension and Transplantation, University of Florida, Gainesville, USA. ejazaa@medicine.ufl.edu
authors.forename: A Ahsan
authors.initials: AA
authors.lastname: Ejaz
authors.forename: Bhagwan
authors.initials: B
authors.lastname: Dass
authors.forename: Ganesh
authors.initials: G
authors.lastname: Kambhampati
authors.forename: Noel I
authors.initials: NI
authors.lastname: Ejaz
authors.forename: Natallia
authors.initials: N
authors.lastname: Maroz
authors.forename: Gurjit S
authors.initials: GS
authors.lastname: Dhatt
authors.forename: Amir A
authors.initials: AA
authors.lastname: Arif
authors.forename: Chirag
authors.initials: C
authors.lastname: Faldu
authors.forename: Miguel A
authors.initials: MA
authors.lastname: Lanaspa
authors.forename: Gaurav
authors.initials: G
authors.lastname: Shah
authors.forename: Richard J
authors.initials: RJ
authors.lastname: Johnson
mesh_terms: D058186:Acute Kidney Injury / Q000453:epidemiology* / Q000209:etiology / Q000517:prevention & control*; D020533:Angiogenesis Inhibitors / Q000097:blood* / Q000276:immunology; D000818:Animals; D002945:Cisplatin / Q000008:administration & dosage / Q000494:pharmacology; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D033461:Hyperuricemia / Q000150:complications / Q000188:drug therapy*; D007668:Kidney / Q000098:blood supply / Q000187:drug effects; D008954:Models, Biological; D010865:Pilot Projects; D051381:Rats; D014503:Urate Oxidase / Q000008:administration & dosage / Q000494:pharmacology*; D014527:Uric Acid / Q000097:blood* / Q000276:immunology; D014661:Vasoconstriction / Q000187:drug effects
chemical_list: D020533:Angiogenesis Inhibitors; D014527:Uric Acid; D014503:Urate Oxidase; D002945:Cisplatin