title: Versatile synthetic strategies for PBCA-based hybrid fluorescent microbubbles and their potential theranostic applications to cell labelling and imaging.
abstract: This research reports the versatile synthetic strategies for hybrid PBCA microbubbles as contrast agents and drug carriers loaded with fluorescent dyes and magnetic nanoparticles serving in vitro cell labelling and in vivo target imaging. These multifunctional probes therefore prove their potential biomedical applications in cancer diagnostics and treatment.
authors.affiliation: Department of Experimental Molecular Imaging (ExMI), Helmholtz Institute, Medical Faculty, RWTH Aachen University, Aachen 52074, Germany. zhliu@ukaachen.de
authors.forename: Zhe
authors.initials: Z
authors.lastname: Liu
authors.forename: Patrick
authors.initials: P
authors.lastname: Koczera
authors.forename: Dennis
authors.initials: D
authors.lastname: Doleschel
authors.forename: Fabian
authors.initials: F
authors.lastname: Kiessling
authors.forename: Jessica
authors.initials: J
authors.lastname: Gätjens
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D003287:Contrast Media / Q000737:chemistry; D003487:Cyanoacrylates / Q000737:chemistry*; D004337:Drug Carriers / Q000737:chemistry; D004659:Enbucrilate; D005456:Fluorescent Dyes / Q000737:chemistry*; D006801:Humans; D008279:Magnetic Resonance Imaging; D058185:Magnetite Nanoparticles / Q000737:chemistry; D051379:Mice; D008819:Mice, Nude; D045423:Microbubbles; D018613:Microscopy, Confocal; D009369:Neoplasms / Q000473:pathology; D040301:Vascular Endothelial Growth Factor Receptor-2 / Q000378:metabolism
chemical_list: D003287:Contrast Media; D003487:Cyanoacrylates; D004337:Drug Carriers; D005456:Fluorescent Dyes; D058185:Magnetite Nanoparticles; D040301:Vascular Endothelial Growth Factor Receptor-2; D004659:Enbucrilate