title: Hepatic echinococcosis: clinical and therapeutic aspects.
abstract: Echinococcosis or hydatid disease (HD) is a zoonosis caused by the larval stages of taeniid cestodes belonging to the genus Echinococcus. Hepatic echinococcosis is a life-threatening disease, mainly differentiated into alveolar and cystic forms, associated with Echinoccus multilocularis (E. multilocularis) and Echinococcus granulosus (E. granulosus) infection, respectively. Cystic echinococcosis (CE) has a worldwide distribution, while hepatic alveolar echinococcosis (AE) is endemic in the Northern hemisphere, including North America and several Asian and European countries, like France, Germany and Austria. E. granulosus young cysts are spherical, unilocular vesicles, consisting of an internal germinal layer and an outer acellular layer. Cyst expansion is associated with a host immune reaction and the subsequent development of a fibrous layer, called the pericyst; old cysts typically present internal septations and daughter cysts. E. multilocularis has a tumor-like, infiltrative behavior, which is responsible for tissue destruction and finally for liver failure. The liver is the main site of HD involvement, for both alveolar and cystic hydatidosis. HD is usually asymptomatic for a long period of time, because cyst growth is commonly slow; the most frequent symptoms are fatigue and abdominal pain. Patients may also present jaundice, hepatomegaly or anaphylaxis, due to cyst leakage or rupture. HD diagnosis is usually accomplished with the combined use of ultrasonography and immunodiagnosis; furthermore, the improvement of surgical techniques, the introduction of minimally invasive treatments [such as puncture, aspiration, injection, re-aspiration (PAIR)] and more effective drugs (such as benzoimidazoles) have deeply changed life expectancy and quality of life of patients with HD. The aim of this article is to provide an up-to-date review of biological, diagnostic, clinical and therapeutic aspects of hepatic echinococcosis.
authors.affiliation: Department of Clinical and Molecular Biomedicine, Division of Infectious Diseases, University of Catania, Via Palermo 636,95125ARNAS Garibaldi Nesima, Catania,Italy. gnunnari@hotmail.com
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Nunnari
authors.forename: Marilia R
authors.initials: MR
authors.lastname: Pinzone
authors.forename: Salvatore
authors.initials: S
authors.lastname: Gruttadauria
authors.forename: Benedetto M
authors.initials: BM
authors.lastname: Celesia
authors.forename: Giordano
authors.initials: G
authors.lastname: Madeddu
authors.forename: Giulia
authors.initials: G
authors.lastname: Malaguarnera
authors.forename: Piero
authors.initials: P
authors.lastname: Pavone
authors.forename: Alessandro
authors.initials: A
authors.lastname: Cappellani
authors.forename: Bruno
authors.initials: B
authors.lastname: Cacopardo
mesh_terms: D000818:Animals; D003937:Diagnosis, Differential; D004444:Echinococcosis, Hepatic / Q000453:epidemiology / Q000473:pathology* / Q000503:physiopathology* / Q000628:therapy*; D004446:Echinococcus / Q000472:pathogenicity / Q000502:physiology; D006790:Host-Parasite Interactions; D006801:Humans; D015047:Zoonoses