title: Anal Carcinoma, Version 2.2012: featured updates to the NCCN guidelines.
abstract: The workup and management of squamous cell anal carcinoma, which represents the most common histologic form of the disease, are addressed in the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Anal Carcinoma. These NCCN Guidelines Insights provide a summary of major discussion points of the 2012 NCCN Anal Carcinoma Panel meeting. In summary, the panel made 4 significant changes to the 2012 NCCN Guidelines for Anal Carcinoma: 1) local radiation therapy was added as an option for the treatment of patients with metastatic disease; 2) multifield technique is now preferred over anteroposterior-posteroanterior (AP-PA) technique for radiation delivery and the AP-PA technique is no longer recommended as the standard of care; 3) PET/CT should now be considered for radiation therapy planning; and 4) a section on risk reduction was added to the discussion section. In addition, the panel discussed the use of PET/CT for the workup of anal canal cancer and decided to maintain the recommendation that it can be considered in this setting. They also discussed the use of PET/CT for the workup of anal margin cancer and for the assessment of treatment response. They reaffirmed their recommendation that PET/CT is not appropriate in these settings.
authors.affiliation: Robert H. Lurie Comprehensive Cancer Center of Northwestern University, USA.
authors.forename: Al B
authors.initials: AB
authors.lastname: Benson
authors.forename: J Pablo
authors.initials: JP
authors.lastname: Arnoletti
authors.forename: Tanios
authors.initials: T
authors.lastname: Bekaii-Saab
authors.forename: Emily
authors.initials: E
authors.lastname: Chan
authors.forename: Yi-Jen
authors.initials: YJ
authors.lastname: Chen
authors.forename: Michael A
authors.initials: MA
authors.lastname: Choti
authors.forename: Harry S
authors.initials: HS
authors.lastname: Cooper
authors.forename: Raza A
authors.initials: RA
authors.lastname: Dilawari
authors.forename: Paul F
authors.initials: PF
authors.lastname: Engstrom
authors.forename: Peter C
authors.initials: PC
authors.lastname: Enzinger
authors.forename: Marwan G
authors.initials: MG
authors.lastname: Fakih
authors.forename: James W
authors.initials: JW
authors.lastname: Fleshman
authors.forename: Charles S
authors.initials: CS
authors.lastname: Fuchs
authors.forename: Jean L
authors.initials: JL
authors.lastname: Grem
authors.forename: Lucille A
authors.initials: LA
authors.lastname: Leong
authors.forename: Edward
authors.initials: E
authors.lastname: Lin
authors.forename: Kilian Salerno
authors.initials: KS
authors.lastname: May
authors.forename: Mary F
authors.initials: MF
authors.lastname: Mulcahy
authors.forename: Kate
authors.initials: K
authors.lastname: Murphy
authors.forename: Eric
authors.initials: E
authors.lastname: Rohren
authors.forename: David P
authors.initials: DP
authors.lastname: Ryan
authors.forename: Leonard
authors.initials: L
authors.lastname: Saltz
authors.forename: Sunil
authors.initials: S
authors.lastname: Sharma
authors.forename: David
authors.initials: D
authors.lastname: Shibata
authors.forename: John M
authors.initials: JM
authors.lastname: Skibber
authors.forename: William
authors.initials: W
authors.lastname: Small
authors.forename: Constantinos T
authors.initials: CT
authors.lastname: Sofocleous
authors.forename: Alan P
authors.initials: AP
authors.lastname: Venook
authors.forename: Christopher
authors.initials: C
authors.lastname: Willett
authors.forename: Deborah A
authors.initials: DA
authors.lastname: Freedman-Cass
mesh_terms: D001005:Anus Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D006801:Humans; D064847:Multimodal Imaging; D049268:Positron-Emission Tomography; D014057:Tomography, X-Ray Computed