title: Varicella-zoster virus: Prevention through vaccination.
abstract: Widespread use of varicella vaccine in the United States has drastically changed the epidemiology of the disease. Although chickenpox is no longer a ubiquitous childhood infection, varicella-zoster virus continues to circulate in the community and nonimmune pregnant women remain at risk. Varicella can cause severe infection in pregnant women, often complicated by viral pneumonia. Maternal varicella occurring in the first half of pregnancy can cause the rare but devastating congenital varicella syndrome, whereas infection in the late stages of pregnancy may cause neonatal varicella. The best approach to avoiding the morbidity and mortality associated with chickenpox in pregnancy is to screen and vaccinate susceptible reproductive-age women.
authors.affiliation: Division of Infectious Diseases, University of Alabama of Birmingham and Birmingham Veterans Administration Medical Center, Birmingham, Alabama, USA. jgnann@uab.edu
authors.forename: John W
authors.initials: JW
authors.lastname: Gnann
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D018890:Chemoprevention; D002644:Chickenpox / Q000151:congenital / Q000175:diagnosis / Q000188:drug therapy / Q000517:prevention & control*; D019433:Chickenpox Vaccine; D004198:Disease Susceptibility; D005260:Female; D006562:Herpes Zoster / Q000188:drug therapy; D014645:Herpesvirus 3, Human / Q000276:immunology; D006801:Humans; D007116:Immunization, Passive; D007136:Immunoglobulins / Q000627:therapeutic use; D007155:Immunologic Factors / Q000627:therapeutic use; D007231:Infant, Newborn; D011024:Pneumonia, Viral / Q000188:drug therapy / Q000209:etiology; D011181:Postnatal Care; D016742:Preconception Care; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control*; D011295:Prenatal Care
chemical_list: D000998:Antiviral Agents; D019433:Chickenpox Vaccine; D007136:Immunoglobulins; D007155:Immunologic Factors; D000212:Acyclovir