title: Inverse correlation between serum levels of selenoprotein P and adiponectin in patients with type 2 diabetes.
abstract: BACKGROUND
  We recently identified selenoprotein P (SeP) as a liver-derived secretory protein that causes insulin resistance in the liver and skeletal muscle; however, it is unknown whether and, if so, how SeP acts on adipose tissue. The present study tested the hypothesis that SeP is related to hypoadiponectinemia in patients with type 2 diabetes.
  
  
  RESULTS
  We compared serum levels of SeP with those of adiponectin and other clinical parameters in 36 patients with type 2 diabetes. We also measured levels of blood adiponectin in SeP knockout mice. Circulating SeP levels were positively correlated with fasting plasma glucose (r = 0.35, P = 0.037) and negatively associated with both total and high-molecular adiponectin in patients with type 2 diabetes (r = -0.355, P = 0.034; r = -0.367, P = 0.028). SeP was a predictor of both total and high-molecular adiponectin, independently of age, body weight, and quantitative insulin sensitivity index (β = -0.343, P = 0.022; β = -0.357, P = 0.017). SeP knockout mice exhibited an increase in blood adiponectin levels when fed regular chow or a high sucrose, high fat diet.
  
  
  CONCLUSIONS
  These results suggest that overproduction of liver-derived secretory protein SeP is connected with hypoadiponectinemia in patients with type 2 diabetes.
authors.affiliation: Department of Disease Control and Homeostasis, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan.
authors.forename: Hirofumi
authors.initials: H
authors.lastname: Misu
authors.forename: Kazuhide
authors.initials: K
authors.lastname: Ishikura
authors.forename: Seiichiro
authors.initials: S
authors.lastname: Kurita
authors.forename: Yumie
authors.initials: Y
authors.lastname: Takeshita
authors.forename: Tsuguhito
authors.initials: T
authors.lastname: Ota
authors.forename: Yoshiro
authors.initials: Y
authors.lastname: Saito
authors.forename: Kazuhiko
authors.initials: K
authors.lastname: Takahashi
authors.forename: Shuichi
authors.initials: S
authors.lastname: Kaneko
authors.forename: Toshinari
authors.initials: T
authors.lastname: Takamura
mesh_terms: D052242:Adiponectin / Q000097:blood*; D000368:Aged; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003924:Diabetes Mellitus, Type 2 / Q000097:blood; D059305:Diet, High-Fat; D019422:Dietary Sucrose / Q000378:metabolism; D005215:Fasting / Q000378:metabolism; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D008875:Middle Aged; D051149:Selenoprotein P / Q000097:blood* / Q000235:genetics
chemical_list: C499918:ADIPOQ protein, human; D052242:Adiponectin; D001786:Blood Glucose; D019422:Dietary Sucrose; D007328:Insulin; D051149:Selenoprotein P