title: Comparison of two in vitro methods to evaluate the water resistance of sunscreens.
abstract: For a long time, the water resistance of sunscreens has been determined in vivo, according to Colipa's (Comité de Liaison des Industries de la Parfumerie) procedure. This method is not so ethical as healthy volunteers are irradiated, and can be replaced by an in vitro method which is easy and quick to perform. The objective of this work was to correlate the experimental device proposed by Choquenet et al. and the dissolutest (Sotax AT6). This equipment is used in the pharmaceutical industry to control the tablets. The experimental conditions have been fixed to correlate the results obtained with both methods. The stirring speed for the dissolutest was fixed at 75 rpm, which is the speed value recommended by the European Pharmacopeia to study the dissolution over time of tablets.
authors.affiliation: LPiC, MMS, EA21601, Faculty of Pharmacy, Université de Nantes, France.
authors.forename: C
authors.initials: C
authors.lastname: Cheignon
authors.forename: C
authors.initials: C
authors.lastname: Couteau
authors.forename: A
authors.initials: A
authors.lastname: Billon-Chabaud
authors.forename: E Marques
authors.initials: EM
authors.lastname: Da Silva
authors.forename: E
authors.initials: E
authors.lastname: Paparis
authors.forename: L J M
authors.initials: LJ
authors.lastname: Coiffard
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000295:instrumentation / Q000379:methods; D004345:Drug Industry / Q000295:instrumentation; D004655:Emulsions; D012995:Solubility; D013473:Sunscreening Agents / Q000737:chemistry* / Q000494:pharmacology; D014867:Water
chemical_list: D004655:Emulsions; D013473:Sunscreening Agents; D014867:Water