title: Effects of pyrethroid insecticide exposure on haematological and haemostatic profiles in rats.
abstract: High malaria burden has led to the increase use of insecticides in the tropics and subtropics. This study thus aimed at assessing the haematological effects and associated haemostatic alteration of pyrethroid insecticide exposure using experimental animal model. Rats of comparable ages and weights were randomized into four groups (A-D). Rats in groups B, C and D were exposed to pyrethroid insecticide by inhalation for 1, 2 and 3 min daily respectively for three weeks. Rats in group A (control) were not exposed. Haematological and haemostatic variables were comparable in all groups (< 0.05). Results from the study show that minimal exposure to pyrethroids is safe.
authors.affiliation: Department of Physiology, College of Health Sciences, Ladoke Akintola University of Technology, Ogbomoso, Oyo State, Nigeria.
authors.forename: W A
authors.initials: WA
authors.lastname: Saka
authors.forename: R E
authors.initials: RE
authors.lastname: Akhigbe
authors.forename: O M
authors.initials: OM
authors.lastname: Azeez
authors.forename: T R
authors.initials: TR
authors.lastname: Babatunde
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000187:drug effects; D004906:Erythrocyte Count; D004912:Erythrocytes / Q000187:drug effects; D006405:Hematology / Q000379:methods; D006487:Hemostasis / Q000187:drug effects; D007300:Insect Control / Q000379:methods; D007306:Insecticides / Q000494:pharmacology* / Q000633:toxicity; D008288:Malaria / Q000517:prevention & control*; D010976:Platelet Count; D011722:Pyrethrins / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D007306:Insecticides; D011722:Pyrethrins