title: Triad of iron deficiency anemia, severe thrombocytopenia and menorrhagia-a case report and literature review.
abstract: BACKGROUND
  Thrombocytosis is a common disorder in patients diagnosed with iron deficiency anemia. The decreased platelet counts commonly found iron deficiency anemia is rarely reported in clinical practice. The exact mechanism of the occurrence of thrombocytopenia in iron deficiency anemia remains unclear. In this case report we discuss a triad of symptoms seen in the African American population: Iron deficiency anemia, menorrhagia and thrombocytopenia.
  
  
  METHODS
  A 40 year old multiparous African-American woman presented with heavy vaginal bleed, severe anemia (3.5 g/dL) and thrombocytopenia (30,000/mm(3)). The peripheral blood smear showed marked microcytic hypochromic cells with decreased platelets counts. After excluding other causes of thrombocytopenia and anemia, increased red cell distribution width and low iron saturation confirmed the diagnosis of iron deficiency anemia. Treatment for iron deficiency anemia was initiated with intravenous and oral iron supplements. Two months following treatment of iron deficiency anemia, the triad of manifestations resolved and patient remained stable.
  
  
  CONCLUSIONS
  Profound degree of iron deficiency anemia can present with thrombocytopenia and severe menorrhagia. Iron replacement should be the main treatment goal in these patients. This case report further supports the 2 compartment model of the role of iron in maintaining platelet counts.
authors.affiliation: Department of Internal Medicine, The Brookdale University Hospital and Medical Center, New York, USA.
authors.forename: Ramy
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authors.forename: Areej
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authors.forename: Shahzad
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authors.lastname: Raza
authors.forename: Muhammad
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authors.lastname: Kafeel
authors.forename: Ridhima
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authors.lastname: Dabas
authors.forename: Elizabeth
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authors.lastname: Haynes
authors.forename: Anjula
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authors.lastname: Gandhi
authors.forename: Omran L
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authors.lastname: Majumder
authors.forename: Mohammad
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authors.lastname: Zaman