title: [Renal abnormalities in ankylosing spondylitis].
abstract: We will study the epidemiologic, clinical, biological, therapeutic, prognostic characteristics and predictive factors of development of nephropathy in ankylosing spondylitis patients. We retrospectively reviewed the medical record of 32 cases with renal involvement among 212 cases of ankylosing spondylitis followed in our service during the period spread out between 1978 and 2006. The renal involvement occurred in all patients a mean of 12 years after the clinical onset of the rheumatic disease. Thirty-two patients presented one or more signs of renal involvement: microscopic hematuria in 22 patients, proteinuria in 23 patients, nephrotic syndrome in 11 patients and decreased renal function in 24 patients (75%). Secondary renal amyloidosis (13 patients), which corresponds to a prevalence of 6,1% and tubulointerstitial nephropathy (7 patients) were the most common cause of renal involvement in ankylosing spondylitis followed by IgA nephropathy (4 patients). Seventeen patients evolved to the end stage renal disease after an average time of 29.8 ± 46 months. The average follow-up of the patients was 4,4 years. By comparing the 32 patients presenting a SPA and renal disease to 88 with SPA and without nephropathy, we detected the predictive factors of occurred of nephropathy: tobacco, intense inflammatory syndrome, sacroileite stage 3 or 4 and presence of column bamboo. The finding of 75% of the patients presented a renal failure at the time of the diagnosis of renal involvement suggests that evidence of renal abnormality involvement should be actively sought in this disease.
authors.affiliation: Service de Médecine A et Laboratoire de Recherche de Pathologie Rénale, Lr00S001, Hôpital Charles-Nicolle, Tunis, Tunisie. bksousou2007@yahoo.fr
authors.forename: Barbouch
authors.initials: B
authors.lastname: Samia
authors.forename: Faiçal
authors.initials: F
authors.lastname: Hazgui
authors.forename: Khaoula Ben
authors.initials: KB
authors.lastname: Abdelghani
authors.forename: Fethi Ben
authors.initials: FB
authors.lastname: Hamida
authors.forename: Rym
authors.initials: R
authors.lastname: Goucha
authors.forename: Hafedh
authors.initials: H
authors.lastname: Hedri
authors.forename: Chokri Ben
authors.initials: CB
authors.lastname: Taarit
authors.forename: Hedi Ben
authors.initials: HB
authors.lastname: Maiz
authors.forename: Adel
authors.initials: A
authors.lastname: Kheder
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007674:Kidney Diseases / Q000453:epidemiology / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D013167:Spondylitis, Ankylosing / Q000150:complications*; D055815:Young Adult