title: [Hepatocellular carcinoma: molecular pathogenesis and novel targets for therapy].
abstract: Hepatocellular carcinomas rank among the most common cancers worldwide. They are                     characterized by phenotypic heterogeneity and poor response to treatment                     modalities. Although considerable progress in diagnosis and management of                     hepatocellular carcinomas has been made over the last decade, the exact biology                     of liver cancer remains poorly understood, overall hindering the development of                     new therapeutic strategies. The development of whole-genome analyses on                     different molecular levels greatly advanced our understanding of                     hepatocarcinogenesis by simultaneously investigating thousands of molecular                     targets. Although implementation of the results from these analyses in routine                     clinical practice is still limited, these next generation technologies offer                     unprecedented insights into the molecular mechanisms of the development of liver                     cancer. Overall, great promise rests on whole genomic approaches to improve the                     diagnostic testing and to identify novel targets for individualized treatment                     modalities in liver cancer.
authors.affiliation: I. Medizinische Klinik und Poliklinik, Universitätsmedizin Mainz, Universität Mainz.
authors.forename: J U
authors.initials: JU
authors.lastname: Marquardt
authors.forename: P R
authors.initials: PR
authors.lastname: Galle
authors.forename: A
authors.initials: A
authors.lastname: Teufel
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000235:genetics / Q000378:metabolism; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000235:genetics / Q000378:metabolism*; D058990:Molecular Targeted Therapy / Q000379:methods*; D009363:Neoplasm Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins