title: [Improving the dissolution rate of poorly water-soluble resveratrol by the ordered mesoporous silica].
abstract: The aim of this study is to synthesize the ordered mesoporous silica (OMS) as drug carrier to improve release property of insoluble drug and investigate the dissolution profile of insoluble drug from the porous carrier. The OMS was obtained by using cetyltrimethyl ammonium bromide as the template and resveratrol was selected as the model drug. The resveratrol-loaded OMS (Res-OMS) were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), N2 adsorption-desorption, X-ray diffraction (XRD) and FT-IR spectroscopy. In vitro drug release behavior was also investigated. It was found that the synthesized OMS showed a large surface area, a narrow pore size distribution and an important mesoporosity associated to hexagonally organized channels. Compared with physical mixture and crystalline powder, resveratrol was in amorphous or molecular form after loading into OMS. The release rate ofresveratrol from drug-loaded OMS was significantly increased suggesting the great potential application of OMS for the formulation of poorly soluble drugs.
authors.affiliation: School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
authors.forename: Gui-Lan
authors.initials: GL
authors.lastname: Quan
authors.forename: Bao
authors.initials: B
authors.lastname: Chen
authors.forename: Zhou-Hua
authors.initials: ZH
authors.lastname: Wang
authors.forename: Han
authors.initials: H
authors.lastname: Wu
authors.forename: Xin-Tian
authors.initials: XT
authors.lastname: Huang
authors.forename: Lin-Na
authors.initials: LN
authors.lastname: Wu
authors.forename: Chuan-Bin
authors.initials: CB
authors.lastname: Wu
mesh_terms: D004337:Drug Carriers; D004339:Drug Compounding; D016503:Drug Delivery Systems; D008855:Microscopy, Electron, Scanning; D046529:Microscopy, Electron, Transmission; D016062:Porosity; D000077185:Resveratrol; D012822:Silicon Dioxide / Q000737:chemistry*; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D013267:Stilbenes / Q000008:administration & dosage / Q000737:chemistry*; D014961:X-Ray Diffraction
chemical_list: D004337:Drug Carriers; D013267:Stilbenes; D012822:Silicon Dioxide; D000077185:Resveratrol