title: A new prospect in cancer therapy: targeting cancer stem cells to eradicate cancer.
abstract: According to the cancer stem cell theory, cancers can be initiated by cancer stem cells. This makes cancer stem cells prime targets for therapeutic intervention. Eradicating cancer stem cells by efficient targeting agents may have the potential to cure cancer. In this review, we summarize recent breakthroughs that have improved our understanding of cancer stem cells, and we discuss the therapeutic strategy of targeting cancer stem cells, a promising future direction for cancer stem cell research.
authors.affiliation: Nanobiomedicine Division, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou, Jiangsu 215123, P. R. China.
authors.forename: Li-Sha
authors.initials: LS
authors.lastname: Chen
authors.forename: An-Xin
authors.initials: AX
authors.lastname: Wang
authors.forename: Bing
authors.initials: B
authors.lastname: Dong
authors.forename: Ke-Feng
authors.initials: KF
authors.lastname: Pu
authors.forename: Li-Hua
authors.initials: LH
authors.lastname: Yuan
authors.forename: Yi-Min
authors.initials: YM
authors.lastname: Zhu
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000378:metabolism; D002454:Cell Differentiation / Q000187:drug effects*; D004337:Drug Carriers; D006046:Gold / Q000008:administration & dosage; D006801:Humans; D049329:Nanostructures; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D014411:Neoplastic Stem Cells / Q000187:drug effects / Q000378:metabolism / Q000473:pathology
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor; D004337:Drug Carriers; D006046:Gold