title: Pharmacological study of the effect of licorice alone and in combination with diclofenac sodium on hepatotoxicity-induced experimentally in rats.
abstract: The protective effect of licorice and diclofenac sodium in doses of 50 mg/kg bwt. and 5 mg/kg bwt. respectively against liver toxicity induced by CCl4 (1ml/kg bwt.) in olive oil [1:1 (v/v)] every other day for 8 weeks and by hepatic ischemia/reperfusion in adult male albino rats was studied. Different antioxidant and liver function parameters were reported to find the protective effect of both licorice and diclofenac sodium against hepatotoxicity. Results showed that licorice protected against CCl4-induced hepatotoxicity as well as ischemia/reperfusion-induced liver injury. On the other hand, diclofenac sodium caused deleterious effects, especially in presence of CCl4, where a high mortality rate was observed.
authors.affiliation: Cairo University.
authors.forename: Hekma A
authors.initials: HA
authors.lastname: Abd El Latif
authors.forename: Sawsan S
authors.initials: SS
authors.lastname: Mahmoud
authors.forename: Gihan Farag
authors.initials: GF
authors.lastname: Asaad
authors.forename: Marwa
authors.initials: M
authors.lastname: El-Hussiny
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D002251:Carbon Tetrachloride / Q000633:toxicity; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology / Q000517:prevention & control*; D004008:Diclofenac / Q000494:pharmacology; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D006035:Glycyrrhiza; D008111:Liver Function Tests; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D015427:Reperfusion Injury / Q000517:prevention & control*
chemical_list: D000975:Antioxidants; D010936:Plant Extracts; D020011:Protective Agents; D004008:Diclofenac; D002251:Carbon Tetrachloride