title: [Application research of hot-melt extrusion in preparation of solid dispersion].
abstract: Hot-melt extrusion (HME) is mainly used to enhance the dissolution rate and bioavailability of poorly water soluble drugs. It has many advantages, such as simple process, continuous operation, high efficiency, on-line monitoring and so on. HME provides an innovative approach, which has been concerned by pharmaceutical workers, for preparation of solid dispersion abroad. This article reviews recent advances on preparation of solid dispersion by HME in preparation processing, carrier materials and quality evaluation in order to further promote and apply HME in preparation of solid dispersion.
authors.affiliation: The State key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau 999078, China.
authors.forename: Mei-Wan
authors.initials: MW
authors.lastname: Chen
authors.forename: Wen-Rong
authors.initials: WR
authors.lastname: Chen
authors.forename: Tong-Kai
authors.initials: TK
authors.lastname: Chen
authors.forename: Rui-E
authors.initials: RE
authors.lastname: Chen
authors.forename: Yi-Tao
authors.initials: YT
authors.lastname: Wang
mesh_terms: D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D004304:Dosage Forms; D004337:Drug Carriers; D004339:Drug Compounding; D006358:Hot Temperature; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D011312:Pressure; D012995:Solubility; D013678:Technology, Pharmaceutical / Q000379:methods*
chemical_list: D004304:Dosage Forms; D004337:Drug Carriers; D004364:Pharmaceutical Preparations