title: Role of tobacco use in the etiology of acoustic neuroma.
abstract: Two previous studies suggest that cigarette smoking reduces acoustic neuroma risk; however, an association between use of snuff tobacco and acoustic neuroma has not been investigated previously. The authors conducted a case-control study in Sweden from 2002 to 2007, in which 451 cases and 710 population-based controls completed questionnaires. Cases and controls were matched on gender, region, and age within 5 years. The authors estimated odds ratios using conditional logistic regression analyses, adjusted for education and tobacco use (snuff use in the smoking analysis and smoking in the snuff analysis). The risk of acoustic neuroma was greatly reduced in male current smokers (odds ratio (OR) = 0.41, 95% confidence interval (CI): 0.23, 0.74) and moderately reduced in female current smokers (OR = 0.70, 95% CI: 0.40, 1.23). In contrast, current snuff use among males was not associated with risk of acoustic neuroma (OR = 0.94, 95% CI: 0.57, 1.55). The authors' findings are consistent with previous reports of lower acoustic neuroma risk among current cigarette smokers than among never smokers. The absence of an association between snuff use and acoustic neuroma suggests that some constituent of tobacco smoke other than nicotine may confer protection against acoustic neuroma.
authors.affiliation: Division of Epidemiology, College of Public Health, Ohio State University, Columbus, USA.
authors.forename: Sadie
authors.initials: S
authors.lastname: Palmisano
authors.forename: Judith
authors.initials: J
authors.lastname: Schwartzbaum
authors.forename: Michaela
authors.initials: M
authors.lastname: Prochazka
authors.forename: David
authors.initials: D
authors.lastname: Pettersson
authors.forename: Tommy
authors.initials: T
authors.lastname: Bergenheim
authors.forename: Rut
authors.initials: R
authors.lastname: Florentzson
authors.forename: Henrik
authors.initials: H
authors.lastname: Harder
authors.forename: Tiit
authors.initials: T
authors.lastname: Mathiesen
authors.forename: Gunnar
authors.initials: G
authors.lastname: Nyberg
authors.forename: Peter
authors.initials: P
authors.lastname: Siesjö
authors.forename: Maria
authors.initials: M
authors.lastname: Feychting
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D006306:Health Surveys; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009464:Neuroma, Acoustic / Q000209:etiology* / Q000517:prevention & control; D016017:Odds Ratio; D012042:Registries; D017678:Sex Distribution; D012907:Smoking; D011795:Surveys and Questionnaires; D013548:Sweden; D014030:Tobacco, Smokeless