title: Complete resolution of laryngeal amyloidosis with radiation treatment.
abstract: BACKGROUND
  Localized amyloidosis of the larynx is a rare entity of unclear etiology. Surgical debulking is the primary treatment modality but often is not curative.
  
  
  RESULTS
  A 41-year-old woman presenting with increasing hoarseness, dysphagia, dyspnea, and weight loss was found to have a submucosal mass in the left false vocal fold. Biopsy of the specimen revealed amyloid. After negative work-up for systemic disease, the patient underwent surgical debulking. Specimens revealed a population of clonal plasma cells demonstrating lambda restriction. The patient was treated with adjuvant external beam radiation to a dose of 45 Gy. At 11 months, the patient's voice, breathing, and swallowing have all improved substantially.
  
  
  CONCLUSIONS
  Recent pathologic studies suggest that localized amyloidosis of the larynx is caused by a localized, nonmalignant plasma cell disorder. Because full resection is difficult, we recommend a combination of surgery and radiation therapy to cure this disease.
authors.affiliation: Department of Radiation Oncology, University of Maryland Medical Center, Baltimore, Maryland, USA. gneuner@umm.edu
authors.forename: Geoffrey A
authors.initials: GA
authors.lastname: Neuner
authors.forename: Ashraf A
authors.initials: AA
authors.lastname: Badros
authors.forename: Tanya K
authors.initials: TK
authors.lastname: Meyer
authors.forename: Nahid M
authors.initials: NM
authors.lastname: Nanaji
authors.forename: William F
authors.initials: WF
authors.lastname: Regine
mesh_terms: D000328:Adult; D000686:Amyloidosis / Q000532:radiotherapy*; D003680:Deglutition Disorders / Q000209:etiology; D004417:Dyspnea / Q000209:etiology; D005260:Female; D006685:Hoarseness / Q000209:etiology; D006801:Humans; D007818:Laryngeal Diseases / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D015431:Weight Loss