title: Should ambulatory blood pressure monitoring be mandatory for future studies in resistant hypertension:  a perspective.
abstract: Recent technologic advances rekindled interventional management of resistant hypertension, either by carotid baroreceptor activation or renal sympathetic denervation. Interventional techniques result in impressive falls in office blood pressure (BP); however, ambulatory BP reductions are rather modest. This disparity between office and ambulatory BP reductions is observed with antihypertensive drugs, but at a much lower degree. Available explanations are not convincing, therefore, we propose that sympathetic overactivity may partially explain this divergence. Further studies are needed to prove or disprove our hypothesis.
authors.forename: Michael
authors.initials: M
authors.lastname: Doumas
authors.forename: Panagiota
authors.initials: P
authors.lastname: Anyfanti
authors.forename: George
authors.initials: G
authors.lastname: Bakris
mesh_terms: D000959:Antihypertensive Agents / Q000494:pharmacology; D001794:Blood Pressure; D001795:Blood Pressure Determination / Q000379:methods; D018660:Blood Pressure Monitoring, Ambulatory; D002986:Clinical Trials as Topic; D004864:Equipment and Supplies; D005060:Europe; D006801:Humans; D006973:Hypertension / Q000175:diagnosis* / Q000628:therapy*; D015337:Multicenter Studies as Topic; D013564:Sympathetic Nervous System; D059466:White Coat Hypertension / Q000175:diagnosis
chemical_list: D000959:Antihypertensive Agents