title: Uveitis and common variable immunodeficiency: data from the DEF-I study and literature review.
abstract: OBJECTIVE
  To examine the relation between uveitis and common variable immunodeficiency (CVID).
  
  
  METHODS
  Retrospective analysis of patients included in the French DEFI cohort of adults with CVID and of patients identified by reviewing the literature.
  
  
  RESULTS
  Four patients were identified in the DEFI study (frequency of uveitis: 1.6%). The course of uveitis was not changed in the patients who started intravenous immunoglobulins replacement therapy after CVID diagnosis. Ten cases of CVID-associated uveitis were listed in the literature. Overall, among the 14 patients, uveitis was always chronic, usually bilateral (n = 11) and granulomatous (n = 9). Seven patients presented with a "sarcoid-likeâ syndrome. Nine patients had granulomatous uveitis suggestive of ocular sarcoidosis. Five patients were treated with local corticosteroids, and 9 required systemic treatment (corticosteroids alone n = 5 and/or immunosuppressive agents n = 4).
  
  
  CONCLUSIONS
  CVID can be associated with uveitis. Since uveitis can reveal the immunodeficiency, CVID diagnosis should be considered at the time of uveitis diagnosis.
authors.affiliation: Department of Internal Medicine, Hôpital Croix-Rousse, Lyon, France.
authors.forename: Florian
authors.initials: F
authors.lastname: Pasquet
authors.forename: Laurent
authors.initials: L
authors.lastname: Kodjikian
authors.forename: Frédéric
authors.initials: F
authors.lastname: Mura
authors.forename: Sophie
authors.initials: S
authors.lastname: Riviere
authors.forename: Julien
authors.initials: J
authors.lastname: Harroche
authors.forename: André-Pierre
authors.initials: AP
authors.lastname: Blanc
authors.forename: Fabrice
authors.initials: F
authors.lastname: Chaix
authors.forename: Eric
authors.initials: E
authors.lastname: Oksenhendler
authors.forename: Pascal
authors.initials: P
authors.lastname: Seve
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D002986:Clinical Trials as Topic; D017074:Common Variable Immunodeficiency / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D005260:Female; D005602:France; D006105:Granulomatous Disease, Chronic / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D015337:Multicenter Studies as Topic; D012189:Retrospective Studies; D012507:Sarcoidosis / Q000175:diagnosis / Q000188:drug therapy; D014605:Uveitis / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D055815:Young Adult
chemical_list: D000305:Adrenal Cortex Hormones; D016756:Immunoglobulins, Intravenous; D007166:Immunosuppressive Agents