title: Ru-catalyzed highly chemo- and enantioselective hydrogenation of γ-halo-γ,δ-unsaturated-β-keto esters under neutral conditions.
abstract: Finely-tuned ruthenium-catalyzed highly chemoselective and enantioselective hydrogenation of γ-halo-γ,δ-unsaturated-β-keto esters at the carbonyl group was achieved under neutral reaction conditions (ee up to 97%). Both olefin and alkenyl halogen moieties, which are labile under hydrogenation conditions, remained untouched during the reaction.
authors.affiliation: School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Ma
authors.forename: Wanfang
authors.initials: W
authors.lastname: Li
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Li
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Tao
authors.forename: Weizheng
authors.initials: W
authors.lastname: Fan
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Xie
authors.forename: Tahar
authors.initials: T
authors.lastname: Ayad
authors.forename: Virginie
authors.initials: V
authors.lastname: Ratovelomanana-Vidal
authors.forename: Zhaoguo
authors.initials: Z
authors.lastname: Zhang
mesh_terms: D000475:Alkenes / Q000737:chemistry; D002384:Catalysis; D004952:Esters; D006865:Hydrogenation; D007659:Ketones / Q000737:chemistry*; D017705:Lignans / Q000737:chemistry; D012428:Ruthenium / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000475:Alkenes; D004952:Esters; D007659:Ketones; D017705:Lignans; D012428:Ruthenium