title: Enantioselective total synthesis and absolute configuration of apiosporic acid.
abstract: The first total synthesis of the polyketide apiosporic acid is presented. Key steps are a Julia-Kocienski olefination, a Suzuki-Miyaura cross-coupling, and an intramolecular Diels-Alder reaction. The absolute configuration of the natural product was determined.
authors.affiliation: Organisch-Chemisches Institut der Ruprecht-Karls-Universität Heidelberg, Im Neuenheimer Feld 270, D-69120 Heidelberg, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Gärtner
authors.forename: David
authors.initials: D
authors.lastname: Kossler
authors.forename: Daniel
authors.initials: D
authors.lastname: Pflästerer
authors.forename: Günter
authors.initials: G
authors.lastname: Helmchen
mesh_terms: D003432:Cross-Linking Reagents / Q000737:chemistry*; D015394:Molecular Structure; D061065:Polyketides / Q000138:chemical synthesis* / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D003432:Cross-Linking Reagents; D061065:Polyketides; C575100:apiosporic acid