title: Correction of tear troughs and periorbital lines with a range of customized hyaluronic acid fillers.
abstract: BACKGROUND
  The periorbital region is a challenging area for injectable filler. Overcorrection and/or the use of unsuitable fillers may lead to unwanted results. As evidence for this region is limited, most physicians follow a trial and error approach.
  
  
  OBJECTIVE
  Assess the efficacy, patient satisfaction, and safety of the HA E filler range in periorbital rejuvenation.
  
  
  METHODS
  This was a multi-center, six-month, open-label study. Subjects could receive HA E Touch, HA E Classic, and HA E Deep for the treatment of tear troughs and periorbital lines at baseline, and an optional touch-up three weeks later. Global aesthetic improvement for both indications, periorbital wrinkle assessments (Lemperle Rating Scale), 3-D volume analysis (for tear troughs only), adverse events and injection site reactions were evaluated at each visit. A subject satisfaction questionnaire was performed three weeks after last injection.
  
  
  RESULTS
  Overall, HA E Classic and Deep were infected for tear troughs, and HA E Touch for periorbital lines. Mean aesthetic improvement in tear troughs was 1.5-2 grades for both products at each post-baseline visit, and results of the clinical evaluation were confirmed by results of 3-D volume analysis. Improvements of periorbital lines in both aesthetic outcomes and wrinkle severity were around 1.5 grades at week 3, and close to 1 grade at month 6. The majority of subjects were satisfied or very satisfied with their aesthetic outcome. Treatments of both indications were safe and well-tolerated, with only mild and transient injection site reactions reported.
  
  
  CONCLUSIONS
  This HA E filler range is suitable for rejuvenation of the periorbital region, which leads to safe results, long-lasting efficacy and high levels of patient satisfaction.
authors.affiliation: Division of Evidence Based Medicine, Charité-Universitätsmedizin, Berlin, Germany. berthold.rzany@charite.de
authors.forename: Berthold
authors.initials: B
authors.lastname: Rzany
authors.forename: Hugues
authors.initials: H
authors.lastname: Cartier
authors.forename: Philippe
authors.initials: P
authors.lastname: Kestermont
authors.forename: Patrick
authors.initials: P
authors.lastname: Trevidic
authors.forename: Gerhard
authors.initials: G
authors.lastname: Sattler
authors.forename: Nabil
authors.initials: N
authors.lastname: Kerrouche
authors.forename: Jean-Charles
authors.initials: JC
authors.lastname: Dhuin
mesh_terms: D000328:Adult; D003357:Cosmetic Techniques; D005143:Eyelids; D005145:Face; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage* / Q000009:adverse effects; D021621:Imaging, Three-Dimensional; D007267:Injections; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D012060:Rejuvenation; D012720:Severity of Illness Index; D015595:Skin Aging; D011795:Surveys and Questionnaires
chemical_list: D006820:Hyaluronic Acid