title: Synthesis and immunostimulating properties of novel adamant-1-yl tripeptides.
abstract: The aim of this work was to prepare L- and D-(adamant-1-yl)-Gly-L-Ala-D-isoGln peptides in order to study their adjuvant (immunostimulating) activities. Adjuvant activity of adamant-1-yl tripeptides was tested in the mouse model using ovalbumin as an antigen and in comparison to the peptidoglycan monomer (PGM; β-D-GlcNAc-(1→4)-D-MurNAc-L-Ala-D-isoGln-mesoDAP(εNH(2) )-D-Ala-D-Ala) and structurally related adamant-2-yl tripeptides.
authors.affiliation: Department of Chemistry, University of Zagreb, Zagreb, Croatia.
authors.forename: Rosana
authors.initials: R
authors.lastname: Ribić
authors.forename: Lidija
authors.initials: L
authors.lastname: Habjanec
authors.forename: Branka
authors.initials: B
authors.lastname: Vranešić
authors.forename: Ruža
authors.initials: R
authors.lastname: Frkanec
authors.forename: Srđanka
authors.initials: S
authors.lastname: Tomić
mesh_terms: D000218:Adamantane / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D000276:Adjuvants, Immunologic / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D051379:Mice; D009842:Oligopeptides / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D010047:Ovalbumin / Q000276:immunology; D010457:Peptidoglycan / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000276:Adjuvants, Immunologic; D009842:Oligopeptides; D010457:Peptidoglycan; D010047:Ovalbumin; D000218:Adamantane