title: Amide-directed tandem C-C/C-N bond formation through C-H activation.
abstract: The transformation of C-H bonds into other chemical bonds is of great significance in synthetic chemistry. C-H bond-activation processes provide a straightforward and atom-economic strategy for the construction of complex structures; as such, they have attracted widespread interest over the past decade. As a prevalent directing group in the field of C-H activation, the amide group not only offers excellent regiodirecting ability, but is also a potential C-N bond precursor. As a consequence, a variety of nitrogen-containing heterocycles have been obtained by using these reactions. This Focus Review addresses the recent research into the amide-directed tandem C-C/C-N bond-formation process through C-H activation. The large body of research in this field over the past three years has established it as one of the most-important topics in organic chemistry.
authors.affiliation: Department of Biochemistry, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd., Dallas, TX 75390-9038, USA. chen.zhu@utsouthwestern.edu
authors.forename: Chen
authors.initials: C
authors.lastname: Zhu
authors.forename: Rui
authors.initials: R
authors.lastname: Wang
authors.forename: John R
authors.initials: JR
authors.lastname: Falck
mesh_terms: D000475:Alkenes / Q000737:chemistry; D000480:Alkynes / Q000737:chemistry; D000577:Amides / Q000737:chemistry*; D002248:Carbon Monoxide / Q000737:chemistry; D003486:Cyanides / Q000737:chemistry; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*
chemical_list: D000475:Alkenes; D000480:Alkynes; D000577:Amides; D003486:Cyanides; D006841:Hydrocarbons, Aromatic; D002248:Carbon Monoxide