title: Release kinetics of cardiac biomarkers in patients undergoing transcoronary ablation of septal hypertrophy.
abstract: BACKGROUND
  The release kinetics of cardiac troponin T measured with conventional vs high-sensitivity cardiac troponin T (hs-cTnT) assays in patients with acute myocardial infarction (AMI) is difficult to establish.
  
  
  METHODS
  We analyzed the release kinetics of cTnT measured by fourth generation and high-sensitivity assays, creatine kinase-MB (CK-MB), and myoglobin in patients with hypertrophic obstructive cardiomyopathy undergoing transcoronary ablation of septal hypertrophy (TASH), a model of AMI. Consecutive patients (n = 21) undergoing TASH were included. Serum and EDTA-plasma samples were collected before and at 15, 30, 45, 60, 75, 90, and 105 min, and 2, 4, 8, and 24 h after TASH.
  
  
  RESULTS
  cTnT concentrations measured by the hs assay were significantly increased at 15 min [21.4 ng/L, interquartile range (IQR) 13.3-39.7 ng/L vs 11.3 ng/L, IQR 6.0-18.8 ng/L at baseline; P = 0.031]. In comparison, cTnT concentrations measured by the conventional fourth generation assay increased significantly at 60 min (30.0 ng/L, IQR 20.0-30.0 ng/L vs <10.0 ng/L, IQR <10.0-10.0 ng/L; P < 0.01), CK-MB at 90 min (8.4 μg/L, IQR 6.9-14.4 μg/L vs 0.9 μg/L, IQR 0.4-1.1 μg/L; P < 0.01), and myoglobin at 30 min (188.0 μg/L, IQR 154.0-233.0 μg/L vs 38.0 μg/L, IQR 28.0-56.0; P < 0.01).
  
  
  CONCLUSIONS
  cTnT concentrations measured by the hs assay were significantly increased after TASH at all of the time points, with a doubling at 15 min after induction of AMI, confirming earlier evidence of myocardial injury compared to the fourth generation cTnT assay and CK-MB and myoglobin.
authors.affiliation: Kerckhoff Heart and Thorax Center, Department of Cardiology, Bad Nauheim, Germany. c.liebetrau@kerckhoff-klinik.de
authors.forename: Christoph
authors.initials: C
authors.lastname: Liebetrau
authors.forename: Helge
authors.initials: H
authors.lastname: Möllmann
authors.forename: Holger
authors.initials: H
authors.lastname: Nef
authors.forename: Sebastian
authors.initials: S
authors.lastname: Szardien
authors.forename: Johannes
authors.initials: J
authors.lastname: Rixe
authors.forename: Christian
authors.initials: C
authors.lastname: Troidl
authors.forename: Matthias
authors.initials: M
authors.lastname: Willmer
authors.forename: Jedrzej
authors.initials: J
authors.lastname: Hoffmann
authors.forename: Michael
authors.initials: M
authors.lastname: Weber
authors.forename: Andreas
authors.initials: A
authors.lastname: Rolf
authors.forename: Christian
authors.initials: C
authors.lastname: Hamm
mesh_terms: D055011:Ablation Techniques; D015415:Biomarkers / Q000097:blood; D002312:Cardiomyopathy, Hypertrophic / Q000097:blood* / Q000601:surgery; D005260:Female; D006346:Heart Septum / Q000601:surgery*; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000601:surgery; D020107:Troponin T / Q000097:blood*
chemical_list: D015415:Biomarkers; D020107:Troponin T