title: Intrathoracic myxosarcoma in a dog.
abstract: A 3-year-old Labrador retriever dog was presented with pyrexia, dyspnoea and tachycardia. A pleural effusion was detected radiographically and ultrasonography showed pleural fluid with floating material. The fluid was drained, revealing a soft tissue mass adjacent to the left ventricle. The aspirated fluid had a proteinaceous and gelatinous appearance. Cytological examination revealed atypical mesenchymal cells in a dense eosinophilic background, interpreted as consistent with the presence of a matrix-secreting tumour, probably a myxosarcoma. Thoracoscopy confirmed the presence of the mass adjacent to the left ventricle, but showed additional smaller pleural masses. Microscopical and immunohistochemical evaluation of a biopsy sample from the mass supported the diagnosis of a myxosarcoma, which was further confirmed by transmission electron microscopy.
authors.affiliation: Central Diagnostic Services, Department of Veterinary Medicine, University of Cambridge, UK. ccs40@cam.ac.uk
authors.forename: C-C
authors.initials: CC
authors.lastname: Sommerey
authors.forename: K A
authors.initials: KA
authors.lastname: Borgeat
authors.forename: U
authors.initials: U
authors.lastname: Hetzel
authors.forename: J
authors.initials: J
authors.lastname: Archer
authors.forename: A G
authors.initials: AG
authors.lastname: Torrance
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism; D002467:Cell Nucleus / Q000648:ultrastructure; D003593:Cytoplasm / Q000648:ultrastructure; D004283:Dog Diseases / Q000378:metabolism / Q000473:pathology*; D004285:Dogs; D017809:Fatal Outcome; D005260:Female; D046529:Microscopy, Electron, Transmission / Q000662:veterinary; D009236:Myxosarcoma / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D010996:Pleural Effusion / Q000175:diagnosis / Q000378:metabolism / Q000662:veterinary; D013899:Thoracic Neoplasms / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D013906:Thoracoscopy / Q000662:veterinary
chemical_list: D014408:Biomarkers, Tumor