title: Infiltrating CD57+ inflammatory cells in head and neck squamous cell carcinoma: clinicopathological analysis and prognostic significance.
abstract: This study investigated the immunodetection of CD57+ inflammatory cells in patients with head and neck squamous cell carcinoma (HNSCC) and its association with clinicopathological parameters and overall survival. Data collected from the morphological analysis and immunohistochemical reaction testing of archived HNSCC specimens (n=70) were statistically analyzed by bivariate and multivariate statistical testing at a significance level of P<0.05. The results indicate that CD57+ inflammatory cells predominate within the peritumoral stroma of HNSCC lesions and the existence of two significant relationships: between high CD57+ cell density and the development of a tumor of a large size [odds ratio (OR)=5.610, 95% confidence interval (CI)=1.516-20.763) and between high CD57+ cell density and the development of locoregional metastatic disease (OR=3.401, 95% CI=1.162-9.951). A significant difference in the rate of survival was detected only in HNSCC patients that presented large size tumors (OR=4.747, 95% CI=1.281-17.594). Together, these results suggest that although high CD57+ inflammatory cell density is associated with HNSCC lesions of greater clinical severity, the variable of cell density is not an independent predictor of HNSCC patient survival. Our findings also suggest that the relatively aggressive infiltration of CD57+ inflammatory cells in the peritumoral stroma of head and neck carcinomas may contribute to an ineffective locoregional antitumoral response.
authors.affiliation: Health Science Programme, Health Research Laboratory, Universidade Estadual de Montes Claros, Montes Claros, Brazil.
authors.forename: Carlos Alberto de Carvalho
authors.initials: CA
authors.lastname: Fraga
authors.forename: Marcos Vinícius Macedo
authors.initials: MV
authors.lastname: de Oliveira
authors.forename: Patrícia Luciana Batista
authors.initials: PL
authors.lastname: Domingos
authors.forename: Ana Cristina de Carvalho
authors.initials: AC
authors.lastname: Botelho
authors.forename: André Luiz Sena
authors.initials: AL
authors.lastname: Guimarães
authors.forename: Andréa
authors.initials: A
authors.lastname: Teixeira-Carvalho
authors.forename: Rodrigo
authors.initials: R
authors.lastname: Correa-Oliveira
authors.forename: Alfredo Maurício Batista
authors.initials: AM
authors.lastname: De Paula
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D018959:CD57 Antigens / Q000276:immunology*; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000276:immunology / Q000401:mortality / Q000473:pathology*; D002452:Cell Count; D002465:Cell Movement; D005260:Female; D006258:Head and Neck Neoplasms / Q000150:complications / Q000276:immunology / Q000401:mortality / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007249:Inflammation / Q000150:complications / Q000276:immunology / Q000401:mortality / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011379:Prognosis; D012189:Retrospective Studies; D012720:Severity of Illness Index; D015996:Survival Rate; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology; D047368:Tumor Burden
chemical_list: D018959:CD57 Antigens