title: Using trichloroacetic acid in the treatment of acanthosis nigricans: a pilot study.
abstract: BACKGROUND
  Despite several therapeutic modalities, acanthosis nigricans (AN) remains a difficult dermatosis to treat.
  
  
  OBJECTIVE
  This study aims to test the safety and efficacy of trichloroacetic acid (TCA) as a chemical peel in the treatment of AN in a random sample of Egyptian female patients.
  
  
  METHODS
  Six females with AN lesions were included in this pilot study. All patients received chemical peeling sessions using TCA over the affected skin lesions. Sessions were carried out to all patients once per week. Treatment was continued for 1 month. Treatment efficacy was evaluated by determining the average rate of response of the lesions to the treatment on a weekly basis.
  
  
  RESULTS
  All patients showed improvement as regard hyperpigmentation, thickening, and the overall appearance. The physician assessment was excellent in three lesions, moderate in five, and was mild in two. No side effects had been reported.
  
  
  CONCLUSIONS
  The study may present TCA as a safe, easy, and an effective method for the treatment of AN.
authors.affiliation: The Department of Dermatology, Kasr El-Ainy University Hospital, Cairo University , Cairo , Egypt.
authors.forename: Amira
authors.initials: A
authors.lastname: Zayed
authors.forename: Rehab Mohamed
authors.initials: RM
authors.lastname: Sobhi
authors.forename: Dalia M
authors.initials: DM
authors.lastname: Abdel Halim
mesh_terms: D000052:Acanthosis Nigricans / Q000188:drug therapy*; D000287:Administration, Topical; D000328:Adult; D002424:Caustics / Q000008:administration & dosage*; D002615:Chemexfoliation; D003879:Dermatologic Agents / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D010865:Pilot Projects; D014238:Trichloroacetic Acid / Q000008:administration & dosage*; D055815:Young Adult
chemical_list: D002424:Caustics; D003879:Dermatologic Agents; D014238:Trichloroacetic Acid