title: Obesity susceptibility loci and dietary intake in the Look AHEAD Trial.
abstract: BACKGROUND
  Genome-wide association studies (GWAS) have identified consistent associations with obesity. However, the mechanisms remain unclear.
  
  
  OBJECTIVE
  The objective was to determine the association between obesity susceptibility loci and dietary intake.
  
  
  METHODS
  The association of GWAS-identified obesity risk alleles (FTO, MC4R, SH2B1, BDNF, INSIG2, TNNI3K, NISCH-STAB1, MTIF3, MAP2K5, QPCTL/GIPR, and PPARG) with dietary intake, measured through food-frequency questionnaires, was investigated in 2075 participants from the Look AHEAD (Action for Health in Diabetes) clinical trial. We adjusted for age, sex, population stratification, and study site.
  
  
  RESULTS
  Obesity risk alleles at FTO rs1421085 significantly predicted more eating episodes per day (P = 0.001)-an effect that persisted after adjustment for body weight (P = 0.004). Risk variants within BDNF were significantly associated with more servings from the dairy product and the meat, eggs, nuts, and beans food groups (P ≤ 0.004). The risk allele at SH2B1 rs4788099 was significantly associated with more servings of dairy products (P = 0.001), whereas the risk allele at TNNI3K rs1514176 was significantly associated with a lower percentage of energy from protein (P = 0.002).
  
  
  CONCLUSIONS
  These findings suggest that obesity risk loci may affect the pattern and content of food consumption among overweight or obese individuals with type 2 diabetes. The Look AHEAD Genetic Ancillary Study was registered at clinicaltrials.gov as NCT01270763 and the Look AHEAD study as NCT00017953.
authors.affiliation: Weight Control and Diabetes Research Center, The Miriam Hospital, Providence, RI 02903, USA. jeanne_mccaffery@brown
authors.forename: Jeanne M
authors.initials: JM
authors.lastname: McCaffery
authors.forename: George D
authors.initials: GD
authors.lastname: Papandonatos
authors.forename: Inga
authors.initials: I
authors.lastname: Peter
authors.forename: Gordon S
authors.initials: GS
authors.lastname: Huggins
authors.forename: Hollie A
authors.initials: HA
authors.lastname: Raynor
authors.forename: Linda M
authors.initials: LM
authors.lastname: Delahanty
authors.forename: Lawrence J
authors.initials: LJ
authors.lastname: Cheskin
authors.forename: Ashok
authors.initials: A
authors.lastname: Balasubramanyam
authors.forename: Lynne E
authors.initials: LE
authors.lastname: Wagenknecht
authors.forename: Rena R
authors.initials: RR
authors.lastname: Wing
mesh_terms: D000483:Alleles; D003611:Dairy Products; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000235:genetics*; D004032:Diet; D004034:Diet Surveys; D004044:Dietary Proteins; D002149:Energy Intake / Q000235:genetics*; D005247:Feeding Behavior / Q000502:physiology*; D005260:Female; D056426:Genetic Loci; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000150:complications / Q000235:genetics*; D012307:Risk Factors; D011795:Surveys and Questionnaires
chemical_list: D004044:Dietary Proteins