title: Molecular scaffolds using multiple orthogonal conjugations: applications in chemical biology and drug discovery.
abstract: Heteromultifunctional scaffolds that harness sequential "click" reactions will find significant utility in the areas of chemical biology and chemically enabled/enhanced biotherapeutics ("chemologics"). Here we review the existing synthetic technologies that illustrate the considerable potential of the field.
authors.affiliation: School of Biosciences, University of Kent, Canterbury, Kent, CT2 7NJ, UK.
authors.forename: David M
authors.initials: DM
authors.lastname: Beal
authors.forename: Lyn H
authors.initials: LH
authors.lastname: Jones
mesh_terms: D001386:Azides / Q000737:chemistry; D003432:Cross-Linking Reagents / Q000737:chemistry; D055808:Drug Discovery; D010091:Oximes / Q000737:chemistry; D013438:Sulfhydryl Compounds / Q000737:chemistry
chemical_list: D001386:Azides; D003432:Cross-Linking Reagents; D010091:Oximes; D013438:Sulfhydryl Compounds