title: Lignans from Schisandra propinqua with inhibitory effects on lymphocyte proliferation.
abstract: Seven new dibenzocyclooctadiene lignans, named propinquain E-K, together with 11 known lignans were isolated from the ethanol extract of the roots of Schisandra propinqua subsp. sinensis. The structures of the new compounds were elucidated by spectroscopic methods, including ¹H- and ¹³C-NMR, 2D-NMR, HR ESI-MS, and CD spectra. Two dibenzocyclooctadienes revealed inhibitory effects on lymphocyte proliferation.
authors.affiliation: School of Pharmacy, Research Center of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.
authors.forename: Mei Na
authors.initials: MN
authors.lastname: Jin
authors.forename: Zhi
authors.initials: Z
authors.lastname: Yao
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Takaishi
authors.forename: Hong Quan
authors.initials: HQ
authors.lastname: Duan
mesh_terms: D000818:Animals; D049109:Cell Proliferation / Q000187:drug effects*; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008214:Lymphocytes / Q000187:drug effects*; D015394:Molecular Structure; D032141:Schisandra / Q000737:chemistry*
chemical_list: D017705:Lignans