title: Identification and screening of carbapenemase-producing Enterobacteriaceae.
abstract: Carbapenem-hydrolysing β-lactamases are the most powerful β-lactamases, being able to hydrolyse almost all β-lactams. They are mostly of the KPC, VIM, IMP, NDM and OXA-48 types. Their current extensive spread worldwide in Enterobacteriaceae is an important source of concern, as these carbapenemase producers are multidrug-resistant. Detection of infected patients and of carriers are the two main approaches for prevention of their spread. Phenotypic and molecular-based techniques are able to identify these carbapenemase producers, although with variable efficiencies. The detection of carriers still relies mostly on the use of screening culture media.
authors.affiliation: Service de Bactériologie-Virologie, INSERM U914 'Emerging Resistance to Antibiotics', Hôpital de Bicêtre, Assistance Publique/Hôpitaux de Paris, Faculté de Médecine et Université Paris-Sud, K.-Bicêtre, France. nordmann.patrice@bct.aphp.fr
authors.forename: P
authors.initials: P
authors.lastname: Nordmann
authors.forename: M
authors.initials: M
authors.lastname: Gniadkowski
authors.forename: C G
authors.initials: CG
authors.lastname: Giske
authors.forename: L
authors.initials: L
authors.lastname: Poirel
authors.forename: N
authors.initials: N
authors.lastname: Woodford
authors.forename: V
authors.initials: V
authors.lastname: Miriagou
mesh_terms: D001426:Bacterial Proteins / Q000096:biosynthesis* / Q000235:genetics; D002353:Carrier State / Q000175:diagnosis / Q000453:epidemiology / Q000382:microbiology*; D003470:Culture Media; D004755:Enterobacteriaceae / Q000145:classification* / Q000201:enzymology / Q000235:genetics / Q000302:isolation & purification*; D004756:Enterobacteriaceae Infections / Q000175:diagnosis / Q000453:epidemiology / Q000382:microbiology*; D006801:Humans; D008403:Mass Screening / Q000379:methods*; D008826:Microbial Sensitivity Tests; D018440:beta-Lactam Resistance; D001618:beta-Lactamases / Q000096:biosynthesis* / Q000235:genetics; D047090:beta-Lactams / Q000494:pharmacology
chemical_list: D001426:Bacterial Proteins; D003470:Culture Media; D047090:beta-Lactams; D001618:beta-Lactamases; C063912:carbapenemase