title: A multipurpose quality assurance phantom for the small animal radiation research platform (SARRP).
abstract: In this work, the suitability and performance of a mouse-size MOSFET (Mousefet) phantom is investigated for routine quality assurance (QA) of the small animal radiation research platform (SARRP). This Mousefet phantom is a simple construction consisting of five micro-MOSFETS custom integrated in a quincunx pattern within a tissue-equivalent phantom, allowing repeat/multiple QA tasks to be quickly performed in one experimental set-up. The Mousefet phantom is particularly evaluated for facilitating SARRP QA tasks which may warrant daily evaluation, including output constancy, isocenter congruency test and cone beam computed tomography (CBCT) image geometric accuracy. Results for the output constancy measurements showed a maximum daily variation of less than 2.6% for all MOSFETS, in consonance with observations from concurrent ion chamber measurements. It is also shown that the design of the Mousefet phantom allows the output check data to be used for prompt verification of beam energy and cone profile constancy. For the isocenter congruency test, it is demonstrated that the Mousefet phantom can detect 0.3 mm deviations of the CBCT isocenter from the radiation isocenter. Meanwhile, results for CBCT image geometric accuracy were consistently found to be within 2% of the expected value. Other CBCT image quality parameters could also be assessed in terms of image intensity constancy, noise and image uniformity. Overall, the results establish the Mousefet phantom as a simple and time-efficient multipurpose tool that could be employed effectively for routine QA of the SARRP.
authors.affiliation: Department of Radiation Oncology, Division of Medical Physics and Biophysics, Brigham and Women's Hospital, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA 02115, USA. wngwa@lroc.harvard.edu
authors.forename: Wilfred
authors.initials: W
authors.lastname: Ngwa
authors.forename: Panagiotis
authors.initials: P
authors.lastname: Tsiamas
authors.forename: Piotr
authors.initials: P
authors.lastname: Zygmanski
authors.forename: G Mike
authors.initials: GM
authors.lastname: Makrigiorgos
authors.forename: Ross I
authors.initials: RI
authors.lastname: Berbeco
mesh_terms: D000818:Animals; D054893:Cone-Beam Computed Tomography / Q000295:instrumentation* / Q000592:standards; D051379:Mice; D019047:Phantoms, Imaging; D011786:Quality Control