title: Real-time continuous glucose monitoring in an intensive care unit: better accuracy in patients with septic shock.
abstract: OBJECTIVE
  This study assessed the accuracy of real-time continuous glucose monitoring system (RTCGMS) devices in an intensive care unit (ICU) to determine whether the septic status of the patient has any influence on the accuracy of the RTCGMS.
  
  
  METHODS
  In total, 41 patients on insulin therapy were included. Patients were monitored for 72 h using RTCGMS. Arterial blood glucose (ABG) samples were obtained following the protocol established in the ICU. The results were evaluated using paired values (excluding those used for calibration) with the performance assessed using numerical accuracy. Nonparametric tests were used to determine statistically significant differences in accuracy.
  
  
  RESULTS
  In total, 956 ABG/RTCGMS pairs were analyzed. The overall median relative absolute difference (RAD) was 13.5%, and the International Organization for Standardization (ISO) criteria were 68.1%. The median RADs reported for patients with septic shock, with sepsis, and without sepsis were 11.2%, 14.3%, and 16.3%, respectively (P<0.05). Measurements meeting the ISO criteria were 74.5%, 65.6%, and 63.7% for patients with septic shock, with sepsis, and without sepsis, respectively (P<0.05).
  
  
  CONCLUSIONS
  The results showed that the septic status of patients influenced the accuracy of the RTCGMS in the ICU. Accuracy was significantly better in patients with septic shock in comparison with the other patient cohorts.
authors.affiliation: Department of Intensive Care, University Hospital of Girona Doctor Josep Trueta, Girona, Spain. carol_lorencio@hotmail.com
authors.forename: Carol
authors.initials: C
authors.lastname: Lorencio
authors.forename: Yenny
authors.initials: Y
authors.lastname: Leal
authors.forename: Alfonso
authors.initials: A
authors.lastname: Bonet
authors.forename: Jorge
authors.initials: J
authors.lastname: Bondia
authors.forename: Cesar C
authors.initials: CC
authors.lastname: Palerm
authors.forename: Abdo
authors.initials: A
authors.lastname: Tache
authors.forename: Josep-Maria
authors.initials: JM
authors.lastname: Sirvent
authors.forename: Josep
authors.initials: J
authors.lastname: Vehi
mesh_terms: D018806:APACHE; D000704:Analysis of Variance; D001786:Blood Glucose / Q000378:metabolism*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000379:methods*; D015203:Reproducibility of Results; D012772:Shock, Septic / Q000097:blood* / Q000503:physiopathology
chemical_list: D001786:Blood Glucose