title: Assessment of macular choroidal thickness by optical coherence tomography and angiographic changes in central serous chorioretinopathy.
abstract: OBJECTIVE
  To investigate the relationship between macular choroidal thickness measured by high-penetrating swept-source optical coherence tomography (SS-OCT) and angiographic findings in central serous chorioretinopathy (CSC).
  
  
  METHODS
  Prospective cross-sectional case series.
  
  
  METHODS
  Thirty-four patients with CSC (44 eyes) and 17 volunteer subjects (17 normal eyes).
  
  
  METHODS
  All subjects underwent a comprehensive ophthalmologic and SS-OCT prototype examination. All patients with CSC also underwent simultaneous fluorescein angiography (FA) and indocyanine green angiography (IA). Mean regional choroidal thickness measurements on the Early Treatment Diabetic Retinopathy Study (ETDRS) layout and squared sector grids were obtained by 3-dimensional raster scanning using SS-OCT.
  
  
  METHODS
  Macular choroidal thickness and angiographic abnormalities.
  
  
  RESULTS
  Mean whole macular choroidal thickness in eyes with CSC (total, 329.3±83.0 μm; classic CSC, 326.9±83.1 μm; chronic CSC, 325.4±93.3 μm; and multifocal posterior pigment epitheliopathy, 359.0±15.5 μm) was greater than that in normal eyes (233.0±67.0 μm) (P < 0.001). In unilateral cases, mean whole macular choroidal thickness was greater in eyes with unilateral CSC than in unaffected fellow eyes (P=0.021). There was no significant difference in choroidal thickness between active eyes and resolved eyes in any of the ETDRS sectors. Mean choroidal thickness was greater in areas with leakage on FA than in areas without leakage (P=0.001). Mean choroidal thickness was greater in areas with choroidal vascular hyperpermeability and in areas with punctate hyperfluorescent spots on IA than in unaffected areas (P<0.001 for both).
  
  
  CONCLUSIONS
  Increased choroidal thickness was observed in the whole macular area of eyes with any of the CSC subtypes. Choroidal thickness was related to leakage from the retinal pigment epithelium, choroidal vascular hyperpermeability, and punctate hyperfluorescent lesions. These findings provide evidence that CSC may be caused by focally increased hydrostatic pressure in the choroid.
authors.affiliation: Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
authors.forename: Pichai
authors.initials: P
authors.lastname: Jirarattanasopa
authors.forename: Sotaro
authors.initials: S
authors.lastname: Ooto
authors.forename: Akitaka
authors.initials: A
authors.lastname: Tsujikawa
authors.forename: Kenji
authors.initials: K
authors.lastname: Yamashiro
authors.forename: Masanori
authors.initials: M
authors.lastname: Hangai
authors.forename: Masaya
authors.initials: M
authors.lastname: Hirata
authors.forename: Akiko
authors.initials: A
authors.lastname: Matsumoto
authors.forename: Nagahisa
authors.initials: N
authors.lastname: Yoshimura
mesh_terms: D056833:Central Serous Chorioretinopathy / Q000175:diagnosis* / Q000503:physiopathology; D002829:Choroid / Q000473:pathology*; D004396:Coloring Agents; D003430:Cross-Sectional Studies; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D021621:Imaging, Three-Dimensional; D007208:Indocyanine Green; D008266:Macula Lutea; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D011446:Prospective Studies; D041623:Tomography, Optical Coherence; D014792:Visual Acuity / Q000502:physiology
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green