title: Does 45,X/46,XX mosaicism with 6-28% of aneuploidy affect the outcomes of IVF or ICSI?
abstract: OBJECTIVE
  Several studies have shown an increased frequency of chromosomal aberrations in female partners of couples examined prior to intracytoplasmic sperm injection (ICSI). A retrospective cohort study was performed to determine whether 45,X/46,XX mosaicism affects the outcomes of in vitro fertilization (IVF) or ICSI.
  
  
  METHODS
  Forty-six women with a 45,X/46,XX karyotype with 6-28% of aneuploidy were compared with 59 control women (46,XX), matched for age, from the female population who underwent IVF or ICSI between 1 January 1996 and 31 December 2006 at the Reproductive Medicine Unit at Brest University Hospital. The outcomes of 254 treatment cycles were compared according to patient karyotype.
  
  
  RESULTS
  No difference was found in the number of retrieved oocytes (8.9 ± 5.5 vs 8.5 ± 4.7; p=0.56) or the number of mature oocytes (7.4 ± 4.7 vs 6.9 ± 4.2; p=0.49) between the 45,X/46,XX group and the 46,XX group, respectively. Fertilization rates did not differ between the groups for either IVF or ICSI. In addition, no difference was found in the pregnancy rate by cycle (17.4% vs 18.7%, respectively; p=0.87). The percentage of first-trimester miscarriages was similar in both groups (13.6% vs 12.5%, respectively; p=0.51).
  
  
  CONCLUSIONS
  45,X/46,XX mosaicism with 6-28% of aneuploidy has no adverse effect on the outcomes of IVF or ICSI among women referred to assisted reproductive technologies.
authors.affiliation: CHU Brest, Service de Gynécologie Obstétrique et Médecine de Reproduction, Brest, France. lionelhomer@yahoo.fr
authors.forename: L
authors.initials: L
authors.lastname: Homer
authors.forename: F
authors.initials: F
authors.lastname: Morel
authors.forename: F
authors.initials: F
authors.lastname: Gallon
authors.forename: M-T
authors.initials: MT
authors.lastname: Le Martelot
authors.forename: V
authors.initials: V
authors.lastname: Amice
authors.forename: V
authors.initials: V
authors.lastname: Kerlan
authors.forename: M
authors.initials: M
authors.lastname: De Braekeleer
mesh_terms: D000328:Adult; D000782:Aneuploidy; D041321:Chromosomes, Human, X; D015331:Cohort Studies; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007247:Infertility, Female / Q000235:genetics / Q000628:therapy; D008297:Male; D009030:Mosaicism; D011247:Pregnancy; D012189:Retrospective Studies; D020554:Sperm Injections, Intracytoplasmic