title: In vitro H(+) -K(+) ATPase inhibitory potential of methanolic extract of Cissus quadrangularis Linn.
abstract: OBJECTIVE
  This study was undertaken to study in vitro H(+) -K(+) ATPase inhibitory potential of methanolic extract of Cissus quadrangularis Linn.  MATERIALS AND MATHODS: Total phenolic and flavonoid contents from extract was quantified and H(+) -K(+) ATPase inhibition assay was performed in presence of different concentrations of standard (omeprazole) and methanol extract.
  
  
  RESULTS
  Extract showed significant (*P < 0.05) proton pump inhibitory activity in the goat gastric mucosal homogenate which was comparable to standard.
  
  
  CONCLUSIONS
  These findings showed that methanolic extract of C. quadrangularis Linn. is potent inhibitor of proton pump.
authors.affiliation: Department of Pharmacology, Shri Ram Institute of Technology -Pharmacy, Jabalpur, Madhya Pradesh, India.
authors.forename: Priyanka
authors.initials: P
authors.lastname: Yadav
authors.forename: Aditya
authors.initials: A
authors.lastname: Ganeshpurkar
authors.forename: Gopal
authors.initials: G
authors.lastname: Rai