title: Modulation of the cardiovascular system by leptin.
abstract: It is well established that individuals with the metabolic syndrome have a significantly increased risk of cardiovascular disease and much effort has been expended to elicit the underlying mechanisms. Various studies have proposed that excessive or deficient physiological effects mediated by leptin make an important contribution, yet many paradoxical observations often preclude a clear definition of the role of leptin. This review article will briefly discuss principal and most recent evidence on direct and indirect regulation of the cardiovascular system by leptin, focusing on cardiac structural and functional as well as vascular effects.
authors.affiliation: Division of Endocrinology, Metabolism and Diabetes and Program in Molecular Medicine, University of Utah School of Medicine, Salt Lake City, Utah, USA.
authors.forename: E Dale
authors.initials: ED
authors.lastname: Abel
authors.forename: Gary
authors.initials: G
authors.lastname: Sweeney
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000378:metabolism / Q000473:pathology; D002319:Cardiovascular System / Q000378:metabolism*; D006801:Humans; D020738:Leptin / Q000172:deficiency / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology
chemical_list: D020738:Leptin