title: Effect of arginine vasopressin on the behavioral activity in the behavior despair depression rat model.
abstract: Arginine vasopressin (AVP), a nonapeptide posterior hormone of the pituitary, is mainly synthesized and secreted in the hypothalamic paraventricular nucleus (PVN) and supraoptic nucleus (SON). Large numbers of studies have reported that AVP plays a role in depression. The present study was to investigate by which level, brain or periphery, AVP affects the behavioral activity in the behavior despair depression rat model. The results showed that (1) either forced swimming or tail suspension significantly increased AVP concentration not only in the brain (PVN, SON, frontal of cortex, hippocampus, amygdala, lumber spinal cord) but also in the periphery (posterior pituitary and serum); (2) intraventricular injection (icv) of AVP decreased the animal immobility time, whereas V₁ receptor antagonist d(CH₂)₅Tyr(Me)AVP (icv) increased the animal immobility time in a dose-dependent manner not only in FST but also in TST, but the V₂ receptor antagonist d(CH₂)₅[D-Ile, Ile, Ala-NH₉]AVP did not change the animal immobility time in FST or TST; (3) V₁, not V₂ receptor antagonist could inhibit the animal immobility time decrease induced by AVP (icv); (4) neither AVP nor its receptor antagonist (including V₁ and V₂ receptor antagonist) influenced the animal immobility time in both FST and TST. The data suggested that AVP in the brain rather than the periphery played a role in the behavior despair depression by V₁, not V₂ receptors, which behavior despair might have a positive feedback effect on central AVP and blood AVP might have a negative feedback on central AVP in the depressive process.
authors.affiliation: College of Pharmacy, Xinxiang Medical University, Xinxiang, Henan 453003, China. bcd2009@126.com
authors.forename: Jun
authors.initials: J
authors.lastname: Yang
authors.forename: Yan-Juan
authors.initials: YJ
authors.lastname: Pan
authors.forename: Zhi-Kui
authors.initials: ZK
authors.lastname: Yin
authors.forename: Guang-Fan
authors.initials: GF
authors.lastname: Hai
authors.forename: Lu
authors.initials: L
authors.lastname: Lu
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhao
authors.forename: Da-Xin
authors.initials: DX
authors.lastname: Wang
authors.forename: Huan
authors.initials: H
authors.lastname: Wang
authors.forename: Gen
authors.initials: G
authors.lastname: Wang
mesh_terms: D000818:Animals; D065092:Antidiuretic Hormone Receptor Antagonists; D001127:Arginine Vasopressin / Q000097:blood / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D003863:Depression / Q000523:psychology*; D006380:Helplessness, Learned; D019417:Hindlimb Suspension; D007275:Injections, Intravenous; D007276:Injections, Intraventricular; D008297:Male; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism; D011863:Radioimmunoassay; D051381:Rats; D017207:Rats, Sprague-Dawley; D013116:Spinal Cord / Q000187:drug effects / Q000378:metabolism; D013550:Swimming / Q000523:psychology
chemical_list: D065092:Antidiuretic Hormone Receptor Antagonists; D001127:Arginine Vasopressin