title: Peripheral blood stem cell collection in allogeneic donors: impact of venous access.
abstract: BACKGROUND
  Peripheral blood stem cell (PBSC) collection is accepted as a routine procedure in related and unrelated healthy donors worldwide. Venous access can be accomplished by peripheral veins or a central venous catheter (CVC). STUDY DESING AND METHODS: We compared efficacy and tolerability of 40 PBSC collections via CVC with 6267 PBSC collections via peripheral veins in healthy allogeneic donors. Results of the leukapheresis procedures and side effects in the donors were evaluated.
  
  
  RESULTS
  The median CD34+ cell counts on Day 5 and the results of the stem cell collection were not significantly different between the two groups of allogeneic donors. Pain or problems at the site of puncture or catheter insertion occurred in 58.6% of the donors with a CVC versus 37.8% of the donors with peripheral venous access (p = 0.03). The incidence and severity of paresthesia during the leukapheresis was not significantly different in both groups of donors (p = 0.09). During follow-up no major adverse events related to CVC were reported.
  
  
  CONCLUSIONS
  Central femoral lines proved to be safe and tolerable in healthy allogeneic donors but peripheral venous access should be preferred, whenever possible.
authors.affiliation: Department of Internal Medicine I, University Hospital Carl Gustav Carus, TU-Dresden; Cellex GmbH, Dresden, Germany. Kristina.Hoelig@uniklinikum-dresden.de
authors.forename: Kristina
authors.initials: K
authors.lastname: Hölig
authors.forename: Matthias
authors.initials: M
authors.lastname: Blechschmidt
authors.forename: Michael
authors.initials: M
authors.lastname: Kramer
authors.forename: Kristin
authors.initials: K
authors.lastname: Zimmer
authors.forename: Frank
authors.initials: F
authors.lastname: Kroschinsky
authors.forename: Kirsten
authors.initials: K
authors.lastname: Poppe-Thiede
authors.forename: Martin
authors.initials: M
authors.lastname: Bornhäuser
authors.forename: Gerhard
authors.initials: G
authors.lastname: Ehninger
mesh_terms: D000328:Adult; D000368:Aged; D001782:Blood Donors; D002405:Catheterization, Central Venous / Q000009:adverse effects / Q000379:methods* / Q000706:statistics & numerical data; D002406:Catheterization, Peripheral / Q000009:adverse effects / Q000379:methods* / Q000706:statistics & numerical data; D005260:Female; D005500:Follow-Up Studies; D019650:Hematopoietic Stem Cell Mobilization / Q000379:methods; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006801:Humans; D015994:Incidence; D007937:Leukapheresis / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010292:Paresthesia / Q000453:epidemiology / Q000517:prevention & control; D014184:Transplantation, Homologous; D055815:Young Adult