title: Treatment of hepatitis C virus infection in adults and children: updated Swedish consensus recommendations.
abstract: Swedish recommendations for the treatment of hepatitis C virus (HCV) infection were updated at a recent expert meeting. Therapy for acute HCV infection should be initiated if spontaneous resolution does not occur within 12 weeks. The recommended standard-of-care therapy for chronic HCV genotype 1 infection is an HCV protease inhibitor in combination with peginterferon (peg-IFN) and ribavirin. Treatment is strongly recommended in patients with bridging fibrosis and cirrhosis, whereas in patients with less advanced fibrosis, deferring therapy may be preferential in light of likely therapeutic improvements in the near future. Patients with chronic genotype 2/3 infection should generally be treated with peg-IFN and ribavirin for 24 weeks. In patients with a very rapid viral response (i.e. HCV RNA below 1000 IU/ml on day 7), or favourable baseline characteristics and undetectable HCV RNA week 4, treatment can be shortened to 12-16 weeks, provided that no dose reductions are needed.
authors.affiliation: Department of Infectious Diseases, Institute of Biomedicine, University of Gothenburg, Göteborg, Sweden. martin.lagging@medfak.gu.se
authors.forename: Martin
authors.initials: M
authors.lastname: Lagging
authors.forename: Ann-Sofi
authors.initials: AS
authors.lastname: Duberg
authors.forename: Rune
authors.initials: R
authors.lastname: Wejstål
authors.forename: Ola
authors.initials: O
authors.lastname: Weiland
authors.forename: Magnus
authors.initials: M
authors.lastname: Lindh
authors.forename: Soo
authors.initials: S
authors.lastname: Aleman
authors.forename: Filip
authors.initials: F
authors.lastname: Josephson
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage*; D002648:Child; D004359:Drug Therapy, Combination / Q000379:methods; D019698:Hepatitis C, Chronic / Q000188:drug therapy*; D006801:Humans; D007372:Interferons / Q000008:administration & dosage; D012254:Ribavirin / Q000008:administration & dosage; D013997:Time Factors
chemical_list: D000998:Antiviral Agents; D012254:Ribavirin; D007372:Interferons