title: Effect of CCR5-Δ32 heterozygosity on HIV-1 susceptibility: a meta-analysis.
abstract: BACKGROUND
  So far, many studies have investigated the distribution of CCR5 genotype between HIV-1 infected patients and uninfected people. However, no definite results have been put forward about whether heterozygosity for a 32-basepair deletion in CCR5 gene (CCR5-Δ32) can affect HIV-1 susceptibility.
  
  
  METHODS
  We performed a meta-analysis of 18 studies including more than 12000 subjects for whom the CCR5-Δ32 polymorphism was genotyped. Odds ratio (OR) with 95% confidence interval (CI) were employed to assess the association of CCR5-Δ32 polymorphism with HIV-1 susceptibility.
  
  
  RESULTS
  Compared with the wild-type CCR5 homozygotes, the pooled OR for CCR5-Δ32 heterozygotes was 1.02 (95%CI, 0.88-1.19) for healthy controls (HC) and 0.95 (95%CI, 0.71-1.26) for exposed uninfected (EU) controls. Similar results were found in stratified analysis by ethnicity, sample size and method of CCR5-Δ32 genotyping.
  
  
  CONCLUSIONS
  The meta-analysis indicated that HIV-1 susceptibility is not significantly affected by heterozygosity for CCR5-Δ32.
authors.affiliation: The State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Science, Fudan University, Shanghai, China.
authors.forename: Sijie
authors.initials: S
authors.lastname: Liu
authors.forename: Chuijin
authors.initials: C
authors.lastname: Kong
authors.forename: Jie
authors.initials: J
authors.lastname: Wu
authors.forename: Hao
authors.initials: H
authors.lastname: Ying
authors.forename: Huanzhang
authors.initials: H
authors.lastname: Zhu
mesh_terms: D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D015658:HIV Infections / Q000235:genetics*; D015497:HIV-1; D006579:Heterozygote; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D019713:Receptors, CCR5 / Q000235:genetics*; D017384:Sequence Deletion
chemical_list: D019713:Receptors, CCR5