title: Trying to make sense of retromer.
abstract: Retromer is a cytosolic protein complex which binds to post-Golgi organelles involved in the trafficking of proteins to the lytic compartment of the cell. In non-plant organisms, retromer mediates the recycling of acid hydrolase receptors from early endosomal (EE) compartments. In plants, retromer components are required for the targeting of vacuolar storage proteins, and for the recycling of endocytosed PIN proteins. However, there are contradictory reports as to the localization of the sorting nexins and the core subunit of retromer. There is also uncertainty as to the identity of the organelles from which vacuolar sorting receptors (VSRs) and endocytosed plasma membrane (PM) proteins are recycled. In this review we try to resolve some of these conflicting observations.
authors.affiliation: Plant Cell Biology, Centre for Organismal Studies, University of Heidelberg, D-69120 Heidelberg, Germany. david.robinson@urz.uni-heidelberg.de
authors.forename: David G
authors.initials: DG
authors.lastname: Robinson
authors.forename: Peter
authors.initials: P
authors.lastname: Pimpl
authors.forename: David
authors.initials: D
authors.lastname: Scheuring
authors.forename: York-Dieter
authors.initials: YD
authors.lastname: Stierhof
authors.forename: Silke
authors.initials: S
authors.lastname: Sturm
authors.forename: Corrado
authors.initials: C
authors.lastname: Viotti
mesh_terms: D000818:Animals; D004705:Endocytosis; D006863:Hydrogen-Ion Concentration; D008322:Mammals / Q000378:metabolism; D046912:Multiprotein Complexes / Q000378:metabolism*; D010944:Plants / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D058305:Sorting Nexins / Q000378:metabolism; D021601:trans-Golgi Network / Q000378:metabolism*
chemical_list: D046912:Multiprotein Complexes; D058305:Sorting Nexins