title: Monodispersed molecularly imprinted polymer for creatinine by modified precipitation polymerization.
abstract: A monodispersed molecularly imprinted polymer (MIP) for creatinine was prepared by modified precipitation polymerization.  The retention and molecular-recognition properties of the prepared MIP were evaluated by the hydrophilic interaction chromatography mode using a mixture of ammonium acetate buffer and acetonitrile as a mobile phase in liquid chromatography.  The MIP had a specific recognition ability for creatinine, while other structurally related compounds, such as hydantoin, 1-methylhydantoin, 2-pyrrolidone, N-hydroxysuccinimide and creatine, could not be recognized on the MIP.  In addition to shape recognition, hydrophilic interactions could work for the recognition of creatinine on the MIP.
authors.affiliation: School of Pharmacy & Pharmaceutical Sciences, Mukogawa Women's University, Nishinomiya, Hyogo, Japan. haginaka@mukogawa-u.ac.jp
authors.forename: Jun
authors.initials: J
authors.lastname: Haginaka
authors.forename: Chitose
authors.initials: C
authors.lastname: Miura
authors.forename: Noriko
authors.initials: N
authors.lastname: Funaya
authors.forename: Hisami
authors.initials: H
authors.lastname: Matsunaga
mesh_terms: D000085:Acetates / Q000737:chemistry; D000097:Acetonitriles / Q000737:chemistry; D002021:Buffers; D002623:Chemistry Techniques, Analytical / Q000379:methods; D003401:Creatine / Q000737:chemistry; D003404:Creatinine / Q000737:chemistry*; D006801:Humans; D006827:Hydantoins / Q000737:chemistry; D007700:Kinetics; D008855:Microscopy, Electron, Scanning / Q000379:methods; D008956:Models, Chemical; D054802:Molecular Imprinting / Q000379:methods*; D011108:Polymers / Q000737:chemistry*; D011760:Pyrrolidinones / Q000737:chemistry; D013388:Succinimides / Q000737:chemistry; D013997:Time Factors
chemical_list: D000085:Acetates; D000097:Acetonitriles; D002021:Buffers; D006827:Hydantoins; D011108:Polymers; D011760:Pyrrolidinones; D013388:Succinimides; C032067:1-methylhydantoin; D003404:Creatinine; C028537:2-pyrrolidone; C001426:N-hydroxysuccinimide; D003401:Creatine; C018824:ammonium acetate; C032159:acetonitrile