title: Expression of gelatinases (MMP-2, MMP-9) and cyclooxygenases (COX-1, COX-2) in some benign salivary gland tumors.
abstract: Salivary gland tumors, most of which are rare benign tumors, represent a histologically heterogenous group with the greatest diversity of morphological and cellular features. The aim of this study is to analyse the expression and possible interactions between gelatinases (MMP-2, MMP-9) and cyclooxygenases (COX-1, COX-2) in some benign salivary gland tumors. We investigated the expression of gelatinases and cyclooxigenases in control salivary gland, Pleomorphic adenoma and Warthin's tumor through immunohistochemistry and Reverse Transcription - Polymerase Chain Reaction (PCR). We identified the expression of both classes of enzyme in normal samples and in the two types of pathological samples without any quantitative differences. From the present data no significant differences emerge in the expression of these enzymes among the different pathologies examined. Nevertheless, due to the small number of samples included in this study, general statements regarding correlation between the degree of severity of the tumoral pathology and the quantitative expression of these potential tumoral markers can not be made.
authors.affiliation: Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche, Sezione di Istologia ed  Embriologia, Universit&#x00E0; degli Studi di Palermo, Palermo, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Lipari
authors.forename: A
authors.initials: A
authors.lastname: Mauro
authors.forename: S
authors.initials: S
authors.lastname: Gallina
authors.forename: S
authors.initials: S
authors.lastname: Tortorici
authors.forename: M
authors.initials: M
authors.lastname: Buscemi
authors.forename: S
authors.initials: S
authors.lastname: Tete
authors.forename: A
authors.initials: A
authors.lastname: Gerbino
mesh_terms: D000235:Adenolymphoma / Q000201:enzymology* / Q000473:pathology; D008949:Adenoma, Pleomorphic / Q000201:enzymology* / Q000473:pathology; D051545:Cyclooxygenase 1 / Q000032:analysis*; D051546:Cyclooxygenase 2 / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D020778:Matrix Metalloproteinase 2 / Q000032:analysis*; D020780:Matrix Metalloproteinase 9 / Q000032:analysis*; D011446:Prospective Studies; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012468:Salivary Gland Neoplasms / Q000201:enzymology* / Q000473:pathology
chemical_list: D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9