title: A new player in the puzzle of filovirus entry.
abstract: Viruses of the genera Ebolavirus and Marburgvirus are filoviruses that cause haemorrhagic fever in primates, with extremely high fatality rates. Studies have focused on elucidating how these viruses enter host cells, with the aim of developing therapeutics. The ebolavirus glycoprotein has been found to play key parts in all steps of entry. Furthermore, recent studies have identified Niemann-Pick C1 (NPC1), a protein that resides deep in the endocytic pathway, as an important host factor in this process.
authors.affiliation: Department of Cell Biology, University of Virginia, 1340 Jefferson Park Avenue, Charlottesville, Virginia 22908-20732, USA. jw7g@virginia.edu
authors.forename: Judith M
authors.initials: JM
authors.lastname: White
authors.forename: Kathryn L
authors.initials: KL
authors.lastname: Schornberg
mesh_terms: D002352:Carrier Proteins / Q000378:metabolism*; D029043:Ebolavirus / Q000472:pathogenicity*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008562:Membrane Glycoproteins / Q000378:metabolism*; D008954:Models, Biological; D008958:Models, Molecular; D000077296:Niemann-Pick C1 Protein; D011991:Receptors, Virus / Q000378:metabolism; D014759:Viral Envelope Proteins / Q000378:metabolism*; D053586:Virus Internalization
chemical_list: D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008562:Membrane Glycoproteins; C106881:NPC1 protein, human; D000077296:Niemann-Pick C1 Protein; D011991:Receptors, Virus; D014759:Viral Envelope Proteins; C113189:envelope glycoprotein, Ebola virus