title: ALDH marks leukemia stem cell.
abstract: In this issue of Blood,Gerber et al use aldehyde dehydrogenase (ALDH) activity to further subdivide the CD34(+)CD38(-) compartment in the bone marrow of acute myeloid leukemia (AML) patients. They identify a unique population with intermediate ALDH activity (ALDH(int)) that contains leukemia stem cells (LSCs). Moreover, persistence of this population after therapy is a marker of clinically significant minimal residual disease.
authors.affiliation: Oregon Health & Science University, USA.
authors.forename: Angela G
authors.initials: AG
authors.lastname: Fleischman
mesh_terms: D000818:Animals; D018952:Antigens, CD34 / Q000378:metabolism*; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis* / Q000473:pathology*; D008297:Male; D014411:Neoplastic Stem Cells / Q000473:pathology*
chemical_list: D018952:Antigens, CD34