title: Long-acting peptidomimetics based DPP-IV inhibitors.
abstract: Pyrrolidine based peptidomimetics are reported as potent and selective DPP-IV inhibitors for the treatment of T2DM. Compounds 16c and 16d showed excellent in vitro potency and selectivity towards DPP-IV and the lead compound 16c showed sustained antihyperglycemic effects, along with improved pharmacokinetic profile.
authors.affiliation: Zydus Research Centre, Sarkhej-Bavla NH 8A Moraiya, Ahmedabad, India.
authors.forename: Pradip
authors.initials: P
authors.lastname: Jadav
authors.forename: Rajesh
authors.initials: R
authors.lastname: Bahekar
authors.forename: Shailesh R
authors.initials: SR
authors.lastname: Shah
authors.forename: Dipam
authors.initials: D
authors.lastname: Patel
authors.forename: Amit
authors.initials: A
authors.lastname: Joharapurkar
authors.forename: Samadhan
authors.initials: S
authors.lastname: Kshirsagar
authors.forename: Mukul
authors.initials: M
authors.lastname: Jain
authors.forename: Mubeen
authors.initials: M
authors.lastname: Shaikh
authors.forename: Kalapatapu V V M
authors.initials: KV
authors.lastname: Sairam
mesh_terms: D000818:Animals; D054873:Dipeptidyl-Peptidase IV Inhibitors / Q000493:pharmacokinetics / Q000494:pharmacology*; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D057786:Peptidomimetics / Q000493:pharmacokinetics / Q000494:pharmacology*
chemical_list: D054873:Dipeptidyl-Peptidase IV Inhibitors; D007004:Hypoglycemic Agents; D057786:Peptidomimetics