title: [Cis-CA1P inhibits tumor cell proliferation and prevents blood vessel formation].
abstract: OBJECTIVE
  To investigate the effects of cis-combretastatin-A1 phosphate (cis-CA1P) on tumor cell proliferation, and its effects on the blood vessel formations.
  
  
  METHODS
  MTT and IC50 values were used to assess the inhibitory effects of cis-CA1P on tumor cell proliferation. Chicken embryo chorioallantoic membrane and thoracic aorta annulations isolated from rats were used to investigate the effects of cis-CAIP on the blood vessel formation.
  
  
  RESULTS
  Cis-CA1P concentration-dependently inhibited the proliferations of several cancer cell lines, including human gastric carcinoma cell line MGC-803, human leukemic monocyte lymphoma cell line U937, human melanoma cell line A375, human colon cancer cell line HCT116, human breast carcinoma cell line MDA-MB-231, and human leukemia cell line K562. Cis-CAIP significantly decreased the formation of blood vessels in chicken embryo chorioallantoic membrane and in thoracic aorta annulations.
  
  
  CONCLUSIONS
  Cis-CA1P inhibits cancer cell proliferation and prevents blood vessel formation.
authors.affiliation: School of Basic Medical Sciences, Nanjing Medical University, Nanjing 210029, China.
authors.forename: Yuan-Zheng
authors.initials: YZ
authors.lastname: Xia
authors.forename: Yong
authors.initials: Y
authors.lastname: Yang
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Wang
authors.forename: Jing-Jing
authors.initials: JJ
authors.lastname: Duan
authors.forename: Xian-Jing
authors.initials: XJ
authors.lastname: Li
authors.forename: An-Peng
authors.initials: AP
authors.lastname: Zhao
authors.forename: Xiu-Lan
authors.initials: XL
authors.lastname: Sun
mesh_terms: D000818:Animals; D001011:Aorta / Q000187:drug effects; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects*; D002642:Chick Embryo; D049033:Chorioallantoic Membrane / Q000098:blood supply / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D009389:Neovascularization, Pathologic / Q000517:prevention & control*; D010710:Phosphates / Q000494:pharmacology*; D051381:Rats; D013267:Stilbenes / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D010710:Phosphates; D013267:Stilbenes; C063690:combretastatin A-1