title: The impact of herbal drug use on adverse drug reaction profiles of patients on antiretroviral therapy in zimbabwe.
abstract: Background. The main objective was to determine the impact of herbal drug use on adverse drug reactions in patients on antiretroviral therapy (ART). Methodology. Patients receiving first-line ART from the national roll-out program participated in this cross-sectional study. Participants were interviewed and a data collection sheet was used to collect information from the corresponding medical record. Results. The majority (98.2%) of participants were using at least one herbal drug together with ART. The most common herbal remedies used were Allium Sativum (72.7%), Bidens pilosa (66.0%), Eucalyptus globulus (52.3%), Moringa oleifera (44.1%), Lippia javanica (36.3%), and Peltoforum africanum (34.3%). Two indigenous herbs, Musakavakadzi (OR = 0.25; 95% CI 0.076-0.828) and Peltoforum africanum (OR = 0.495; 95% CI 0.292-0.839) reduced the occurrence of adverse drug events. Conclusions. The use of herbal drugs is high in the HIV-infected population and there is need for pharmacovigilance programs to recognize the role they play in altering ADR profiles.
authors.affiliation: School of Pharmacy, University of Zimbabwe, P.O. Box MP167, Mount Pleasant, Harare, Zimbabwe.
authors.forename: Tinashe
authors.initials: T
authors.lastname: Mudzviti
authors.forename: Charles C
authors.initials: CC
authors.lastname: Maponga
authors.forename: Star
authors.initials: S
authors.lastname: Khoza
authors.forename: Qing
authors.initials: Q
authors.lastname: Ma
authors.forename: Gene D
authors.initials: GD
authors.lastname: Morse