title: Prognostic value of survivin expression in Wilms tumor.
abstract: OBJECTIVE
  To determine survivin expression patterns in Wilms tumor (WT) and compare it with the expression in normal renal tissue. Also, to analyse cytoplasmic and nuclear survivin expression in relation to histological type, prognostic group and tumor stage.
  
  
  METHODS
  Immunohistochemical expression of survivin was analysed in 59 cases of primary WT and in 10 normal kidney specimens, taken from the same patients, but distant from the tumor.
  
  
  RESULTS
  51 out of 59 cases of WT (86.44%) showed decreased cytoplasmic survivin expression and 4 out of 59 cases of WT (6.78%) showed nuclear overexpression of survivin. There was statistically significant difference in the frequency of decreased cytoplasmic expression of survivin in individual components of WT (p=0.005). Decreased cytoplasmic expression of survivin in epithelial, blastemal and stromal component was found significantly more often in low stage WT compared to high stage WT (Fisher exact test, p=0.0002, p=0.002, p=0.002, respectively). There was no statistically significant difference in the frequency of survivin nuclear overexpression between different stages of WT (Fisher exact test, p=0.564), histological types (Fisher exact test, p=0.915), or between different prognostic groups (Fisher exact test, p=1).
  
  
  CONCLUSIONS
  Decreased survivin cytoplasmic expression or nuclear overexpression may be related to favorable prognosis of WT.
authors.affiliation: Institute of Pathology, School of Medicine, University of Belgrade, Serbia.
authors.forename: G
authors.initials: G
authors.lastname: Basta-Jovanovic
authors.forename: S
authors.initials: S
authors.lastname: Radojevic-Skodric
authors.forename: D
authors.initials: D
authors.lastname: Brasanac
authors.forename: S
authors.initials: S
authors.lastname: Djuricic
authors.forename: J
authors.initials: J
authors.lastname: Milasin
authors.forename: L
authors.initials: L
authors.lastname: Bogdanovic
authors.forename: D
authors.initials: D
authors.lastname: Opric
authors.forename: M
authors.initials: M
authors.lastname: Savin
authors.forename: I
authors.initials: I
authors.lastname: Baralic
authors.forename: M
authors.initials: M
authors.lastname: Jovanovic
mesh_terms: D002467:Cell Nucleus / Q000737:chemistry; D002648:Child; D002675:Child, Preschool; D003593:Cytoplasm / Q000737:chemistry; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D051034:Inhibitor of Apoptosis Proteins / Q000032:analysis*; D007680:Kidney Neoplasms / Q000737:chemistry* / Q000401:mortality / Q000473:pathology; D008297:Male; D009367:Neoplasm Staging; D011379:Prognosis; D000077022:Survivin; D009396:Wilms Tumor / Q000737:chemistry* / Q000401:mortality / Q000473:pathology
chemical_list: C107489:BIRC5 protein, human; D051034:Inhibitor of Apoptosis Proteins; D000077022:Survivin