title: Impact of age of onset of illness on clinical phenotype in OCD.
abstract: BACKGROUND
  This study aims to examine the demographic, clinical and comorbid patterns in a large sample of adult OCD subjects at a specialty OCD clinic in India.
  
  
  METHODS
  Consecutive patients (n=545) who consulted a specialty OCD Clinic over 5 years at a large psychiatric hospital in India were evaluated with the Mini International Neuropsychiatric Interview, the Yale-Brown Obsessive-Compulsive Scale, and the Clinical Global Impression scale.
  
  
  RESULTS
  Earlier age onset of OCD (years) was characterized by male preponderance (19.61±7.98 vs. 25.19±10.39, U=23453.5, p=<0.001), positive family history of OCD (19.60±10.02 vs. 22.27±9.20, U=16590.5, p<0.001) and presence of tic disorder (16.28±8.21 vs. 22.01±9.38, OR=0.86, p=0.001). In addition, early age of onset was associated with presence of sexual obsessions (18.92±7.49 vs. 22.88±9.82, OR=0.96, p=0.02), hoarding (19.61±9.32 vs. 22.21±9.36, OR=0.95, p=0.009), repeating rituals (19.76±8.37 vs. 23.29±9.84, OR=0.95, p=0.006) and need to touch compulsions (16.40±7.19 vs. 22.36±9.43, OR=0.89, p<0.001).
  
  
  CONCLUSIONS
  Our findings from a large sample not only confirm that early onset OCD could be a valid and distinct subtype of OCD but also support the cross-cultural similarity of early onset phenotype.
authors.affiliation: Department of Psychiatry, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore 560029, India. jairamnimhans@gmail.com
authors.forename: Janardhanan C
authors.initials: JC
authors.lastname: Narayanaswamy
authors.forename: Biju
authors.initials: B
authors.lastname: Viswanath
authors.forename: Anish
authors.initials: A
authors.lastname: Veshnal Cherian
authors.forename: Suresh
authors.initials: S
authors.lastname: Bada Math
authors.forename: Thennarasu
authors.initials: T
authors.lastname: Kandavel
authors.forename: Y C
authors.initials: YC
authors.lastname: Janardhan Reddy
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D017668:Age of Onset; D000368:Aged; D003192:Compulsive Behavior / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D009770:Obsessive Behavior / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D009771:Obsessive-Compulsive Disorder / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D010641:Phenotype; D011569:Psychiatric Status Rating Scales; D012737:Sex Factors; D013981:Tic Disorders / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*