title: A novel quinoline-based two-photon fluorescent probe for detecting Cd2+ in vitro and in vivo.
abstract: A new two-photon fluorescent Cd(2+) probe APQ is developed by introducing a N(1),N(1)-dimethyl-N(2)-(pyridin-2-ylmethyl)ethane-1,2-diamine binding group and a 4-methoxyphenylvinyl conjugation-enhancing group to the 2- and 6-positions of quinoline. This probe shows a large red shift and good emission enhancement under Cd(2+) binding. It also exhibits a high ion selectivity for Cd(2+) (especially over Zn(2+)) and a large two-photon absorption cross section at 710 nm. Two-photon microscopy imaging studies reveal that the new probe is non-toxic and cell-permeable and can be used to detect intracellular Cd(2+) under two-photon excitation.
authors.affiliation: Department of Chemistry, Anhui University, Hefei 230039, P. R. China.
authors.forename: Yiming
authors.initials: Y
authors.lastname: Li
authors.forename: Hanbao
authors.initials: H
authors.lastname: Chong
authors.forename: Xiangming
authors.initials: X
authors.lastname: Meng
authors.forename: Shuxin
authors.initials: S
authors.lastname: Wang
authors.forename: Manzhou
authors.initials: M
authors.lastname: Zhu
authors.forename: Qingxiang
authors.initials: Q
authors.lastname: Guo
mesh_terms: D002104:Cadmium / Q000032:analysis* / Q000737:chemistry; D004579:Electron Transport; D004785:Environmental Pollutants / Q000032:analysis* / Q000737:chemistry; D005456:Fluorescent Dyes / Q000737:chemistry* / Q000633:toxicity; D006367:HeLa Cells; D006801:Humans; D006863:Hydrogen-Ion Concentration; D057054:Molecular Imaging; D017785:Photons; D011804:Quinolines / Q000737:chemistry*; D013057:Spectrum Analysis
chemical_list: D004785:Environmental Pollutants; D005456:Fluorescent Dyes; D011804:Quinolines; D002104:Cadmium; C037219:quinoline