title: Quinazoline-tyrphostin as a new class of antitumor agents, molecular properties prediction, synthesis and biological testing.
abstract: A new series of substituted quinazolin-4-(3H)-one-tyrphostin derivatives was prepared and screened for their cytotoxic activity against three tumor cell lines, namely human breast cancer cell line (MCF-7), human cervical cancer cell line (HeLa) and human hepatocellular liver carcinoma cell line (HepG2) using the colorimetric MTT assay. Among the current series, 10 compounds exhibited remarkable in vitro antiproliferative activity against the three tested cell lines with the IC(50) values ranging from 0.009 to 0.015 mM. All the compounds showed suitable drug like characteristics according to Lipinski's rule.
authors.affiliation: Department of Pharmaceutical Chemistry, College of Pharmacy, Salman Bin Abdulaziz University, PO Box 173, Alkharj 11942, Saudi Arabia. ahmed.alafeefy@yahoo.com
authors.forename: Ahmed M
authors.initials: AM
authors.lastname: Alafeefy
authors.forename: Saleh I
authors.initials: SI
authors.lastname: Alqasoumi
authors.forename: Abdelkader E
authors.initials: AE
authors.lastname: Ashour
authors.forename: Vijay
authors.initials: V
authors.lastname: Masand
authors.forename: Nabila A
authors.initials: NA
authors.lastname: Al-Jaber
authors.forename: Taibi
authors.initials: T
authors.lastname: Ben Hadda
authors.forename: Menshawy A
authors.initials: MA
authors.lastname: Mohamed
mesh_terms: D000178:Acrylamides / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D060326:Chemistry Techniques, Synthetic; D004353:Drug Evaluation, Preclinical; D006801:Humans; D020128:Inhibitory Concentration 50; D011799:Quinazolines / Q000737:chemistry*; D020032:Tyrphostins / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000178:Acrylamides; D000970:Antineoplastic Agents; D011799:Quinazolines; D020032:Tyrphostins