title: Comparison of epirubicin-iodized oil suspension and emulsion for transcatheter arterial chemoembolization in VX2 tumor.
abstract: To compare the antitumor efficacy and safety of transcatheter arterial chemoembolization (TACE) by epirubicin suspension (epirubicin suspension: epirubicin-iodized oil mixture without solution) to that by epirubicin emulsion (epirubicin emulsion: epirubicin-iodized oil mixture with solution), the efficacy of treatment by administration of either an epirubicin suspension or emulsion was examined in an animal model. Changes in plasma epirubicin concentration were compared over 24 h immediately after treatment, and enhanced ultrasonographic and histopathological analysis subsequently conducted 7 days after treatment to determine the growth ratio and proportion of viable tumor cells. The growth ratio and proportion of viable tumor cells were found to be significantly lower in the suspension group than in the emulsion group while the plasma epirubicin concentration was found to be significantly higher in the suspension group than in the emulsion group. These results indicate that administration of an epirubicin suspension is a superior form of TACE compared to that of administration of an epirubicin emulsion.
authors.affiliation: Department of Radiology, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8603, Japan. s9015@nms.ac.jp
authors.forename: Tatsuo
authors.initials: T
authors.lastname: Ueda
authors.forename: Satoru
authors.initials: S
authors.lastname: Murata
authors.forename: Takahiko
authors.initials: T
authors.lastname: Mine
authors.forename: Shiro
authors.initials: S
authors.lastname: Onozawa
authors.forename: Munehiko
authors.initials: M
authors.lastname: Onda
authors.forename: Zenya
authors.initials: Z
authors.lastname: Naito
authors.forename: Yasuo
authors.initials: Y
authors.lastname: Amano
authors.forename: Shinichiro
authors.initials: S
authors.lastname: Kumita
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001158:Arteries; D016461:Chemoembolization, Therapeutic / Q000379:methods*; D015251:Epirubicin / Q000493:pharmacokinetics / Q000627:therapeutic use*; D005260:Female; D007459:Iodized Oil / Q000737:chemistry*; D009374:Neoplasms, Experimental / Q000473:pathology / Q000628:therapy*; D011817:Rabbits
chemical_list: D000970:Antineoplastic Agents; D015251:Epirubicin; D007459:Iodized Oil