title: Guidelines for evaluating and managing children born with disorders of sexual development.
abstract: Children born with disorders of sexual differentiation (DSD) pose numerous challenges for the parents, family, and treating physicians. The pediatrician is usually the first medical contact for newborns with DSD or for toddlers and children who present with DSD at a later time. Several years ago, we formed a Gender Medicine Team (GMT) at Baylor College of Medicine and Texas Children's Hospital (TCH) to explore and evaluate the most appropriate management strategies, which had long been a matter of concern and contention. Subsequently, the GMT, composed of experts in the fields of endocrinology, ethics, genetics, gynecology, psychology, pediatric surgery, and urology, formed a Task Force to evaluate the information available from our own experiences and from reviews of the literature. Utilizing the Grading of Recommendation, Assessment, Development and Evaluation (GRADE) system to assess the evidence and recommendations, the Task Force developed a consensus statement for clinical management of DSD and for making appropriate sex assignments.
authors.affiliation: Baylor College of Medicine Texas Children’s Hospital, Houston, TX 77030, USA.
authors.forename: Ganka
authors.initials: G
authors.lastname: Douglas
authors.forename: Marni E
authors.initials: ME
authors.lastname: Axelrad
authors.forename: Mary L
authors.initials: ML
authors.lastname: Brandt
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Crabtree
authors.forename: Jennifer E
authors.initials: JE
authors.lastname: Dietrich
authors.forename: Shannon
authors.initials: S
authors.lastname: French
authors.forename: Sheila
authors.initials: S
authors.lastname: Gunn
authors.forename: Lefkothea
authors.initials: L
authors.lastname: Karaviti
authors.forename: Monica E
authors.initials: ME
authors.lastname: Lopez
authors.forename: Charles G
authors.initials: CG
authors.lastname: Macias
authors.forename: Laurence B
authors.initials: LB
authors.lastname: McCullough
authors.forename: Deepa
authors.initials: D
authors.lastname: Suresh
authors.forename: Elise
authors.initials: E
authors.lastname: Austin
authors.forename: V
authors.initials: V
authors.lastname: Reid Sutton
mesh_terms: D002675:Child, Preschool; D032921:Consensus; D012734:Disorders of Sex Development / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics / Q000601:surgery; D006801:Humans; D007223:Infant; D013781:Texas