title: Temporal resolution deficits in patients with refractory complex partial seizures and mesial temporal sclerosis (MTS).
abstract: We studied the temporal resolution ability in patients with refractory complex partial seizures and mesial temporal sclerosis (MTS) using Gaps-In-Noise (GIN) test in a prospective cross-sectional study. Thirteen patients with right MTS (age: 31±7.67 years; M:F=8:5) and 13 patients with left MTS (age: 25.76±8.26 years; M:F=9:4) having normal hearing and mini-mental state examination (MMSE) score of >23/30 were recruited. Fifty healthy volunteers (26.3±5.17 years; M:F=28:22) formed the control group. Gaps-In-Noise test demonstrated impaired temporal resolution: 69.2% of patients with right MTS (RMTS) and 76.9% of patients with left MTS (LMTS) had abnormal scores in the right ear for gap detection threshold (GDT) measure. Similarly, 53.8% of patients in the RMTS group and 76.9% of patients in the LMTS group had abnormal scores in the left ear. In percentage of correct identification (PCI), 46.1% of patients with RMTS and 69.2% of patients with LMTS had poorer scores in the right ear, whereas 46.1% of patients with RMTS and 61.5% of patients with LMTS had poorer scores in the left ear. Both patient groups, viz., RMTS and LMTS, demonstrated bilateral temporal resolution deficits.
authors.affiliation: Department of Speech Pathology and Audiology, National Institute of Mental Health and Neurosciences, Bangalore, India.
authors.forename: Rajasekaran
authors.initials: R
authors.lastname: Aravindkumar
authors.forename: N
authors.initials: N
authors.lastname: Shivashankar
authors.forename: P
authors.initials: P
authors.lastname: Satishchandra
authors.forename: Sanjib
authors.initials: S
authors.lastname: Sinha
authors.forename: J
authors.initials: J
authors.lastname: Saini
authors.forename: D K
authors.initials: DK
authors.lastname: Subbakrishna
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods; D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D003430:Cross-Sectional Studies; D017029:Epilepsy, Complex Partial / Q000150:complications* / Q000473:pathology*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D007805:Language Development Disorders / Q000175:diagnosis / Q000209:etiology*; D008297:Male; D009483:Neuropsychological Tests; D011446:Prospective Studies; D011601:Psychophysics; D012598:Sclerosis / Q000150:complications / Q000473:pathology; D012684:Sensory Thresholds; D017603:Signal Detection, Psychological; D013702:Temporal Lobe / Q000473:pathology*; D055815:Young Adult