title: A comparative study of clinical features between monotypic and dual infection cases with Chikungunya virus and dengue virus in West Bengal, India.
abstract: Chikungunya virus (CHIKV) and dengue virus (DENV) are circulating individually in the state of West Bengal, India. However, after 1965 the dual-infection caused by both viruses had not been recorded until 2010. In 2010, an investigation of the febrile cases was carried out to confirm the involvement of both viruses simultaneously. A total of 550 blood samples were tested for the detection of immunoglobulin M (IgM) antibody against both CHIKV and DENV. Serology by the enzyme-linked immunosorbent assay method confirmed that 131 (23.8%) and 104 (18.9%) patients had IgM antibody against CHIKV and DENV, respectively, whereas 68 (12.4%) had IgM antibodies against both CHIKV and DENV. Fever, joint pain, rashes, headache, myalgia, and nausea/vomiting are the common features in the case of both monotypic and dual-infection. Severe arthralgia and swelling of joints were common only in CHIKV-positive cases and abdominal pain was mainly associated with DENV infection. Diarrhea was reported only by the dual-infected patients (16.2%).
authors.affiliation: ICMR Virus Unit, ID and BG Hospital, Beliaghata, Kolkata, India. taraphdar.debjani@gmail.com
authors.forename: Debjani
authors.initials: D
authors.lastname: Taraphdar
authors.forename: Arindam
authors.initials: A
authors.lastname: Sarkar
authors.forename: Bansi B
authors.initials: BB
authors.lastname: Mukhopadhyay
authors.forename: Shyamalendu
authors.initials: S
authors.lastname: Chatterjee
mesh_terms: D000293:Adolescent; D000328:Adult; D018354:Alphavirus Infections / Q000150:complications / Q000453:epidemiology* / Q000821:virology; D000914:Antibodies, Viral / Q000097:blood; D018771:Arthralgia / Q000150:complications / Q000473:pathology / Q000821:virology; D002646:Chikungunya virus / Q000472:pathogenicity*; D002648:Child; D002675:Child, Preschool; D060085:Coinfection / Q000150:complications / Q000453:epidemiology* / Q000821:virology; D003715:Dengue / Q000150:complications / Q000453:epidemiology* / Q000821:virology; D003716:Dengue Virus / Q000472:pathogenicity*; D004196:Disease Outbreaks; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D007194:India / Q000453:epidemiology; D007223:Infant; D008297:Male; D008875:Middle Aged; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral; D007075:Immunoglobulin M