title: Effect of spinally administered simvastatin on the formalin-induced nociceptive response in mice.
abstract: Clinical and experimental observations indicated that 3-hydroxy-3-methylglutaryl CoA reductase inhibitor statins have pleiotropic effects. The present study determined the antinociceptive property of centrally administered simvastatin on the formalin-induced nociception in the mouse. Intrathecal administration of simvastatin at doses of 0.5 - 50 nmol dose-dependently attenuated the second, but not the first, phase of the formalin-induced nociception, which was partially reversed by mevalonate (5 µmol). Intracerebroventricular injection of simvastatin (50 nmol) did not affect the formalin-induced nociception. These results suggest that simvastatin-induced antinociception is mediated by attenuation of the sensitization of spinal nociceptive transmission.
authors.affiliation: Second Department of Pharmacology, School of Pharmaceutical Sciences, Kyushu University of Health and Welfare, Nobeoka-shi, Miyazaki, Japan. ohsawa@phar.nagoya-cu.ac.jp
authors.forename: Masahiro
authors.initials: M
authors.lastname: Ohsawa
authors.forename: Junpei
authors.initials: J
authors.lastname: Mutoh
authors.forename: Shohei
authors.initials: S
authors.lastname: Yamamoto
authors.forename: Hideki
authors.initials: H
authors.lastname: Ono
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Hisa
mesh_terms: D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D005557:Formaldehyde; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology*; D007278:Injections, Spinal / Q000379:methods; D008297:Male; D008798:Mevalonic Acid / Q000494:pharmacology; D051379:Mice; D008813:Mice, Inbred ICR; D059225:Nociception / Q000187:drug effects*; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy*; D010147:Pain Measurement / Q000379:methods; D019821:Simvastatin / Q000494:pharmacology*; D013116:Spinal Cord / Q000187:drug effects*
chemical_list: D000700:Analgesics; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D005557:Formaldehyde; D019821:Simvastatin; D008798:Mevalonic Acid