title: Added sugar, glycemic index and load in colon cancer risk.
abstract: OBJECTIVE
  There is a growing body of in-vivo evidences that sucrose-rich diets cause mutations in the rat colon epithelium, with several biological mechanism hypothesized, but epidemiological studies have yielded conflicting results. In order to provide a quantification of the magnitude of the risk of colon cancer for high intake of added sugar, high dietary glycemic index and glycemic load, we performed a meta-analysis based on a systematic review of the literature to date.
  
  
  RESULTS
  Recent epidemiological data indicate a lack of association between high intake of added sugar, high-glycemic index and glycemic load diets and risk of colon cancer.
  
  
  CONCLUSIONS
  There is no consistent evidence from epidemiological studies, although a modest excess risk emerged in case-control studies, that added sugars, dietary glycemic index and glycemic load are associated with increased risk of colon cancer, independently from their effect on energy intake, overweight, obesity and diabetes, which are related to excess colon cancer risk.
authors.affiliation: Department of Epidemiology, University of Milan, Milan, Italy.
authors.forename: Carlotta
authors.initials: C
authors.lastname: Galeone
authors.forename: Claudio
authors.initials: C
authors.lastname: Pelucchi
authors.forename: Carlo
authors.initials: C
authors.lastname: La Vecchia
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003110:Colonic Neoplasms / Q000097:blood / Q000139:chemically induced*; D019422:Dietary Sucrose / Q000009:adverse effects* / Q000378:metabolism; D002149:Energy Intake; D038321:Glycemic Index; D006801:Humans
chemical_list: D001786:Blood Glucose; D019422:Dietary Sucrose