title: CO2 gas induced drug release from pH-sensitive liposome to circumvent doxorubicin resistant cells.
abstract: A novel pH-sensitive liposome encapsulating doxorubicin was prepared by a NH(4)HCO(3) gradient method. The liposomes were able to release the drug at pH 5.0 by the production of CO(2) gas. More importantly, the drug-loaded liposome effectively circumvented the breast cancer cells resistant to doxorubicin.
authors.affiliation: CAS Key Laboratory for Biological Effects of Nanomaterials & Nanosafety, National Center for Nanoscience and Technology, 11 Beiyijie, Zhongguancun, Beijing 100190, China.
authors.forename: Juan
authors.initials: J
authors.lastname: Liu
authors.forename: Huili
authors.initials: H
authors.lastname: Ma
authors.forename: Tuo
authors.initials: T
authors.lastname: Wei
authors.forename: Xing-Jie
authors.initials: XJ
authors.lastname: Liang
mesh_terms: D002245:Carbon Dioxide / Q000378:metabolism*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects*; D004317:Doxorubicin / Q000737:chemistry / Q000494:pharmacology*; D019008:Drug Resistance, Neoplasm; D005740:Gases / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008081:Liposomes / Q000737:chemistry*
chemical_list: D005740:Gases; D008081:Liposomes; D002245:Carbon Dioxide; D004317:Doxorubicin