title: Neurological symptoms and signs in HTLV-1 patients with overactive bladder syndrome.
abstract: OBJECTIVE
  To compare neurological symptoms and signs in HTLV-1 asymptomatic carriers and HTLV-1 patients with overactive bladder (OB) syndrome.
  
  
  METHODS
  We studied 102 HTLV-1 positive individuals without HAM/TSP (HTLV-1 associated myelopathy/tropical spastic paraparesis) divided into two groups according to the presence or absence of OB syndrome. Clinical interview, neurological exam and proviral load was performed in all patients.
  
  
  CONCLUSIONS
  Individuals with OB were more commonly female (84.3 vs. 60.8% of asymptomatics, p=0.01). The prevalence of neurological complaints was higher in OB group, especially hand or foot numbness and arm or leg weakness. There was no difference between the groups in neurological strength and reflexes. Weakness complaint remained strongly associated with OB in multivariate logistic regression analysis adjusting for sex and age [adjusted odds ratio and 95%CI 3.59 (1.45-8.88) in arms and 6.68 (2.63-16.93) in legs]. Proviral load was also different between the two groups with higher level on OB individuals.
authors.affiliation: Immunology Department, Bahia Federal University, Salvador, BA, Brazil. davi81@me.com
authors.forename: Davi Tanajura
authors.initials: DT
authors.lastname: Costa
authors.forename: André Luiz Muniz Alves dos
authors.initials: AL
authors.lastname: Santos
authors.forename: Néviton Matos de
authors.initials: NM
authors.lastname: Castro
authors.forename: Isadora Cristina de
authors.initials: IC
authors.lastname: Siqueira
authors.forename: Edgar Marcelino de
authors.initials: EM
authors.lastname: Carvalho Filho
authors.forename: Marshall Jay
authors.initials: MJ
authors.lastname: Glesby
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015493:Paraparesis, Tropical Spastic / Q000150:complications*; D012044:Regression Analysis; D012307:Risk Factors; D012959:Socioeconomic Factors; D053201:Urinary Bladder, Overactive / Q000821:virology*; D019562:Viral Load