title: Pancreatic carcinosarcoma in a cat.
abstract: A 10-year-old female American shorthair cat was presented for evaluation of weight loss. An intra-abdominal mass was found on ultrasonography and laparotomy was performed. The mass was located in the left uterine horn and further masses were found in the pancreas, greater omentum and diaphragm. Microscopical examination revealed that the pancreatic mass had epithelial and mesenchymal components, which on immunohistochemistry expressed cytokeratin and vimentin, respectively. In addition, some spindle cells expressed vimentin and E-cadherin, which might suggest epithelial to mesenchymal transition. In contrast, the uterine, omental and diaphragmatic masses had only mesenchymal composition. The pancreatic lesion is proposed to be a primary carcinosarcoma with metastasis of only the mesenchymal component to distant sites. This the first report of pancreatic carcinosarcoma in a cat.
authors.affiliation: Laboratory of Veterinary Pathology, Tokyo University of Agriculture and Technology, Tokyo, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Yamamoto
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
authors.forename: K
authors.initials: K
authors.lastname: Uchida
authors.forename: N
authors.initials: N
authors.lastname: Onda
authors.forename: M
authors.initials: M
authors.lastname: Shibutani
authors.forename: K
authors.initials: K
authors.lastname: Mitsumori
mesh_terms: D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism; D015820:Cadherins / Q000378:metabolism; D002296:Carcinosarcoma / Q000378:metabolism / Q000556:secondary / Q000601:surgery / Q000662:veterinary*; D002371:Cat Diseases / Q000473:pathology* / Q000601:surgery; D002415:Cats; D017809:Fatal Outcome; D005260:Female; D007633:Keratins / Q000378:metabolism; D014594:Uterine Neoplasms / Q000378:metabolism / Q000473:pathology / Q000601:surgery / Q000662:veterinary*; D014746:Vimentin / Q000378:metabolism
chemical_list: D014408:Biomarkers, Tumor; D015820:Cadherins; D014746:Vimentin; D007633:Keratins