title: Trends in susceptibility of vancomycin-resistant Enterococcus faecium to tigecycline, daptomycin, and linezolid and molecular epidemiology of the isolates: results from the Tigecycline In Vitro Surveillance in Taiwan (TIST) study, 2006 to 2010.
abstract: Among the 219 vancomycin-resistant Enterococcus faecium isolates collected in 20 Taiwanese hospitals from 2006 to 2010, all were susceptible to linezolid and daptomycin, and 98.6% were susceptible to tigecycline. There was a shift toward higher tigecycline MIC values (MIC(90)s) from 2006-2007 (0.06 μg/ml) to 2008-2010 (0.12 μg/ml). The MIC(90)s of daptomycin and linezolid remained stationary. Although pulsotypes among the isolates from the 20 hospitals varied, intrahospital spreading of several clones was identified in 13 hospitals.
authors.affiliation: Section of Infectious Diseases, Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan.
authors.forename: Hsih-Yeh
authors.initials: HY
authors.lastname: Tsai
authors.forename: Chun-Hsing
authors.initials: CH
authors.lastname: Liao
authors.forename: Yen-Hsu
authors.initials: YH
authors.lastname: Chen
authors.forename: Po-Liang
authors.initials: PL
authors.lastname: Lu
authors.forename: Cheng-Hua
authors.initials: CH
authors.lastname: Huang
authors.forename: Chin-Te
authors.initials: CT
authors.lastname: Lu
authors.forename: Yin-Ching
authors.initials: YC
authors.lastname: Chuang
authors.forename: Shih-Ming
authors.initials: SM
authors.lastname: Tsao
authors.forename: Yao-Shen
authors.initials: YS
authors.lastname: Chen
authors.forename: Yung-Ching
authors.initials: YC
authors.lastname: Liu
authors.forename: Wei-Yu
authors.initials: WY
authors.lastname: Chen
authors.forename: Tsrang-Neng
authors.initials: TN
authors.lastname: Jang
authors.forename: Hsiu-Chen
authors.initials: HC
authors.lastname: Lin
authors.forename: Chih-Ming
authors.initials: CM
authors.lastname: Chen
authors.forename: Zhi-Yuan
authors.initials: ZY
authors.lastname: Shi
authors.forename: Sung-Ching
authors.initials: SC
authors.lastname: Pan
authors.forename: Jia-Ling
authors.initials: JL
authors.lastname: Yang
authors.forename: Hsiang-Chi
authors.initials: HC
authors.lastname: Kung
authors.forename: Chun-Eng
authors.initials: CE
authors.lastname: Liu
authors.forename: Yu-Jen
authors.initials: YJ
authors.lastname: Cheng
authors.forename: Jien-Wei
authors.initials: JW
authors.lastname: Liu
authors.forename: Wu
authors.initials: W
authors.lastname: Sun
authors.forename: Lih-Shinn
authors.initials: LS
authors.lastname: Wang
authors.forename: Wen-Chien
authors.initials: WC
authors.lastname: Ko
authors.forename: Kwok-Woon
authors.initials: KW
authors.lastname: Yu
authors.forename: Ping-Cherng
authors.initials: PC
authors.lastname: Chiang
authors.forename: Ming-Hsun
authors.initials: MH
authors.lastname: Lee
authors.forename: Chun-Ming
authors.initials: CM
authors.lastname: Lee
authors.forename: Gwo-Jong
authors.initials: GJ
authors.lastname: Hsu
authors.forename: Po-Ren
authors.initials: PR
authors.lastname: Hsueh
mesh_terms: D000081:Acetamides / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017576:Daptomycin / Q000494:pharmacology*; D016521:Electrophoresis, Gel, Pulsed-Field; D016984:Enterococcus faecium / Q000187:drug effects*; D000069349:Linezolid; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000031:analogs & derivatives* / Q000494:pharmacology; D017720:Molecular Epidemiology / Q000379:methods*; D023303:Oxazolidinones / Q000494:pharmacology*; D013624:Taiwan; D000078304:Tigecycline; D020713:Vancomycin Resistance / Q000235:genetics
chemical_list: D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D000078304:Tigecycline; D008911:Minocycline; D000069349:Linezolid; D017576:Daptomycin