title: [Synthesis and structure-activity relationship of N-(2-arylethyl) isoquinoline derivatives as anti-cancer agents].
abstract: A series of novel N-(2-arylethyl) isoquinoline derivatives were designed, synthesized and evaluated for their anti-cancer activities. Among these analogs, compound 9a exhibited the potential anti-cancer activities on HepG2 and HCT116 cells with IC50 values of 2.52 and 1.99 microg x mL(-1), respectively. Cell cycle was blocked at S phase of HepG2 cells treated with 9a by flow cytometry detection. Our results provided a basis for the development of a new series of anti-cancer candidates.
authors.affiliation: Institute of Medicinal Biotechnology, China Academy of Medical Science and Peking Union Medical College, Beijing 100050, China.
authors.forename: Yan-Xiang
authors.initials: YX
authors.lastname: Wang
authors.forename: Wu-Li
authors.initials: WL
authors.lastname: Zhao
authors.forename: Chong-Wen
authors.initials: CW
authors.lastname: Bi
authors.forename: Yang-Biao
authors.initials: YB
authors.lastname: Li
authors.forename: Rong-Guang
authors.initials: RG
authors.lastname: Shao
authors.forename: Dan-Qing
authors.initials: DQ
authors.lastname: Song
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002453:Cell Cycle / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D045325:HCT116 Cells; D056945:Hep G2 Cells; D006801:Humans; D020128:Inhibitory Concentration 50; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D007546:Isoquinolines