title: Intragastric pressure as a determinant of food intake.
abstract: BACKGROUND
  Different studies indicated a correlation between intragastric pressure (IGP) and satiation. Our aim was to investigate this correlation while artificially increasing the IGP.
  
  
  METHODS
  In 12 fasted healthy volunteers an infusion catheter and a manometry probe were positioned intragastrically. Intragastric pressure was increased using a custom-made belt before or progressively during intragastric nutrient infusion. Nutrient drink (1.5 kcal mL(-1)) was intragastrically infused at 60 mL min(-1) . The subjects scored satiation using a 6-point Likert scale until maximum, when the infusion ended and the belt was released. Results are presented as mean ± S.E.M. and compared using a paired t-test.
  
  
  RESULTS
  When the belt was tightened before the nutrient infusion, fasting IGP was significantly increased (13.6 ± 1.3 vs 9.6 ± 0.9 mmHg; P < 0.05) but no differences in satiation could be observed. When progressively tightening the belt during nutrient infusion the IGP increased with 0.43 ± 0.04 mmHg per minute while in control experiments this was 0.28 ± 0.05 mmHg per minute (P < 0.01). During the latter experiment satiation linearly increased with 0.35 ± 0.03 and 0.29 ± 0.02 units per minute until maximal satiation (P < 0.01) while maximum volume consumed was 926 ± 66 and 1095 ± 82 mL when progressively increasing the IGP vs control respectively (P < 0.01).
  
  
  CONCLUSIONS
  These findings indicate that IGP per se does not affect satiation but that a gradual IGP increase during food intake is associated with decreased food intake, indicating that gastric accommodation is an important determinant of food intake.
authors.affiliation: Translational Research Center for Gastrointestinal Disorders, University of Leuven, Leuven, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Janssen
authors.forename: S
authors.initials: S
authors.lastname: Verschueren
authors.forename: J
authors.initials: J
authors.lastname: Tack
mesh_terms: D000328:Adult; D003187:Compliance / Q000502:physiology*; D004435:Eating / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008365:Manometry; D011312:Pressure; D012527:Satiation / Q000502:physiology*; D013270:Stomach / Q000502:physiology*