title: Comparison of total laryngectomy with surgical (cricohyoidopexy) and nonsurgical organ-preservation modalities in advanced laryngeal squamous cell carcinomas: A multicenter retrospective analysis.
abstract: BACKGROUND
  Functional outcome and quality of life (QOL) have become relevant endpoints in the field of laryngeal oncology, leading to the emergence of organ-preserving strategies.
  
  
  METHODS
  The medical records of 166 patients with advanced (stages III and IV) laryngeal squamous cell carcinoma (SCC) who were treated with a total laryngectomy, radiochemotherapy, or cricohyoidopexy (CHP) were reviewed.
  
  
  RESULTS
  In the whole series, no statistically significant differences among the 3 treatment arms with respect to the overall survival (OS) and disease-specific survival (DSS) rates were observed. The organ-preservation rate was 45% for radiotherapy and 76.7% for CHP (p = .0002). Among the cT4a cases, a longer survival was observed for the patients treated with total laryngectomy (3 yr-OS = 78% vs 68% for CHP and 54% for radiochemotherapy, p = .031).
  
  
  CONCLUSIONS
  In advanced laryngeal SCC, CHP shows survival rates comparable to those of radiochemotherapy and a higher larynx-preservation rate, although it may not replace radiochemotherapy because it can be recommended only in selected cases.
authors.affiliation: Institute of Otorhinolaryngology, Policlinico Agostino Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy. francescobussu@yahoo.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Bussu
authors.forename: Gaetano
authors.initials: G
authors.lastname: Paludetti
authors.forename: Giovanni
authors.initials: G
authors.lastname: Almadori
authors.forename: Armando
authors.initials: A
authors.lastname: De Virgilio
authors.forename: Jacopo
authors.initials: J
authors.lastname: Galli
authors.forename: Francesco
authors.initials: F
authors.lastname: Miccichè
authors.forename: Mario
authors.initials: M
authors.lastname: Tombolini
authors.forename: Davide
authors.initials: D
authors.lastname: Rizzo
authors.forename: Andrea
authors.initials: A
authors.lastname: Gallo
authors.forename: Veronica
authors.initials: V
authors.lastname: Giglia
authors.forename: Antonio
authors.initials: A
authors.lastname: Greco
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Valentini
authors.forename: Marco
authors.initials: M
authors.lastname: De Vincentiis
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000601:surgery* / Q000628:therapy; D059248:Chemoradiotherapy; D003131:Combined Modality Therapy; D003413:Cricoid Cartilage / Q000473:pathology* / Q000601:surgery; D005260:Female; D006258:Head and Neck Neoplasms / Q000601:surgery* / Q000628:therapy; D006801:Humans; D007822:Laryngeal Neoplasms / Q000601:surgery* / Q000628:therapy; D007825:Laryngectomy / Q000379:methods*; D007830:Larynx / Q000473:pathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011788:Quality of Life; D012189:Retrospective Studies; D000077195:Squamous Cell Carcinoma of Head and Neck; D015996:Survival Rate; D016896:Treatment Outcome