title: Refractory semantic access dysphasia resulting from resection of a left frontal glioma.
abstract: The existence of semantic access disorders is now well established, however the precise cognitive and anatomical underpinnings are still debated. Here we describe the case of a patient that became aphasic after the resection of a left frontal glioma. Detailed lesion reconstruction indicates that the lesion was mostly restricted to the left dorsal and ventral prefrontal cortices and the underlying white matter, but sparing temporal lobes. Critically, the patient showed all the signs of refractory semantic access dysphasia, supporting the association between this syndrome and damage to left prefrontal areas likely to subserve retrieval and selection mechanisms for verbal material.
authors.affiliation: Neurosurgery Unit, A.O.U. Santa Maria della Misericordia, Udine, Italy. fabio.campanella@uniud.it
authors.forename: Fabio
authors.initials: F
authors.lastname: Campanella
authors.forename: Cristiano
authors.initials: C
authors.lastname: Crescentini
authors.forename: Alessandro
authors.initials: A
authors.lastname: Mussoni
authors.forename: Miran
authors.initials: M
authors.lastname: Skrap
mesh_terms: D001037:Aphasia / Q000209:etiology* / Q000473:pathology / Q000523:psychology*; D001288:Attention / Q000502:physiology; D001932:Brain Neoplasms / Q000601:surgery*; D056344:Executive Function; D005260:Female; D005625:Frontal Lobe / Q000601:surgery*; D005910:Glioma / Q000601:surgery*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007807:Language Tests; D008279:Magnetic Resonance Imaging; D008568:Memory / Q000502:physiology; D009483:Neuropsychological Tests; D011183:Postoperative Complications / Q000523:psychology*; D011930:Reaction Time / Q000502:physiology; D055815:Young Adult