title: BRCA1 as tumor suppressor: lord without its RING?
abstract: BRCA1 is a tumor suppressor with critical roles in the maintenance of genomic stability. It encodes a large protein with an amino-terminal RING domain that possesses ubiquitin-ligase activity. Given the occurrence of numerous cancer-causing mutations within its RING domain, investigators have long suspected that BRCA1's ubiquitin ligase is important for its tumor suppression and DNA repair activities. Using genetically engineered mouse models, two recent studies shed light on this age-old hypothesis.
authors.affiliation: Department of Genetics, Harvard Medical School, 77 Ave, Louis Pasteur, Boston, MA 02115, USA.
authors.forename: Andrew E H
authors.initials: AE
authors.lastname: Elia
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Elledge
mesh_terms: D000818:Animals; D019313:BRCA1 Protein / Q000737:chemistry* / Q000235:genetics* / Q000378:metabolism; D001943:Breast Neoplasms / Q000235:genetics; D004260:DNA Repair; D016147:Genes, Tumor Suppressor; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D009154:Mutation; D017434:Protein Structure, Tertiary
chemical_list: D019313:BRCA1 Protein; C492913:BRCA1 protein, human