title: [Meta-analysis of the association of Pro12Ala polymorphism of peroxisome proliferator activated receptor gamma gene with type 2 diabetes in Chinese Han population].
abstract: OBJECTIVE
  To evaluate the association of Pro12Ala polymorphism of peroxisome proliferator activated receptor gamma (PPARgamma) gene with type 2 diabetes (T2DM) in Chinese Han population.
  
  
  METHODS
  The present investigation was carried out using the keywords "PPARgamma", "pparg", "Pro12Ala", "type 2 diabetes", and "Chinese. The odds ratios (OR) for Ala12 used as the metric of choice were calculated in the dominant and additive model separately. The Meta-analysis was conducted by software STATA 11.0.
  
  
  RESULTS
  (1) We identified 22 studies, of which 17 studies involving 3927 type 2 diabetes cases and 3364 controls fell into the inclusion criteria. The analysis indicated no significant inter-study heterogeneity and publication bias. (2) The frequencies of the minor allele Ala12 in type 2 diabetes and control groups were 4.8% and 4.6% respectively. (3) The combined overall OR of dominant and additive model calculated by fix-effects meta-analysis for type 2 diabetes and the Pro12Ala polymorphism, were 0.95 (95% CI: 0.80, 1.12) and 0.93 (95% CI: 0.79, 1.09) respectively.
  
  
  CONCLUSIONS
  In this meta-analysis, the Pro12Ala gene variant (rs1801282) is not found to be associated with the susceptibility for type 2 diabetes in Chinese Han population.
authors.affiliation: Department of Endocrinology, People's Hospital, Peking University, Beijing 100044, China.
authors.forename: Wu-Lan
authors.initials: WL
authors.lastname: Guo
authors.forename: Yong
authors.initials: Y
authors.lastname: Tang
authors.forename: Xue-Yao
authors.initials: XY
authors.lastname: Han
authors.forename: Li-Nong
authors.initials: LN
authors.lastname: Ji
mesh_terms: D044466:Asian People / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006801:Humans; D047495:PPAR gamma / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D047495:PPAR gamma