title: The role of the breast cancer surgeon in personalized cancer care: clinical utility of the 21-gene assay.
abstract: BACKGROUND
  Breast cancer surgeons represent the first line of defense for many patients battling this disease. They often have the first contact to discuss treatment options with the patient after diagnosis. However, the potential impact of this consultation has evolved with the arrival of commercialized multigene prognostic and predictive tests that continue to reshape the landscape of breast cancer management, including modern surgical practice.
  
  
  METHODS
  This review was compiled from peer-reviewed literature indexed in PubMed.
  
  
  CONCLUSIONS
  The advent of genomic analysis has advanced the treatment and management of breast cancer toward the goal of personalized care. Therefore, the role of the surgeon now extends beyond extirpation of the tumor and includes an understanding of the biology of the disease as well as an appreciation of this new technology. Breast cancer surgeons should seize this opportunity to provide patients and colleagues with this information in an expeditious manner to optimize clinical outcomes.
authors.affiliation: H. Lee Moffitt Cancer Center and Research Institute, 12902 Magnolia Drive, Tampa, FL 33612, USA. Christine.laronga@moffitt.org
authors.forename: Christine
authors.initials: C
authors.lastname: Laronga
authors.forename: Jay K
authors.initials: JK
authors.lastname: Harness
authors.forename: Matthew
authors.initials: M
authors.lastname: Dixon
authors.forename: Patrick I
authors.initials: PI
authors.lastname: Borgen
mesh_terms: D014408:Biomarkers, Tumor; D001943:Breast Neoplasms / Q000235:genetics / Q000601:surgery*; D003131:Combined Modality Therapy; D003661:Decision Support Techniques; D005260:Female; D005819:Genetic Markers; D005820:Genetic Testing / Q000379:methods; D006801:Humans; D008495:Medical Oncology; D010819:Physician's Role; D057285:Precision Medicine; D011379:Prognosis; D013043:Specialties, Surgical
chemical_list: D014408:Biomarkers, Tumor; D005819:Genetic Markers