title: Implantable (bio)polymer coated titanium scaffolds: a review.
abstract: In the current review we aim to give an overview of the state of the art of the research on (bio)polymer functionalised titanium implants for bone tissue engineering applications. After a short introduction on bone tissue engineering and the requirements the applied materials have to meet, an extensive discussion on titanium in bone tissue engineering will be given. Starting with a short description of both the titanium bulk and surface properties, the requirement for surface modified titanium will be highlighted. The discussion will encompass inorganic and organic chemical modifications and a combination thereof with a focus on the organic modifications. Within the latter type of modification, physical adsorption, physical incorporation and covalent immobilisation will be compared. In the final part of the review an overview will be given of the fabrication and characterisation of three-dimensional titanium scaffolds.
authors.affiliation: Polymer Chemistry and Biomaterials Research Group, Ghent, Belgium.
authors.forename: Els
authors.initials: E
authors.lastname: Vanderleyden
authors.forename: Steven
authors.initials: S
authors.lastname: Mullens
authors.forename: Jan
authors.initials: J
authors.lastname: Luyten
authors.forename: Peter
authors.initials: P
authors.lastname: Dubruel
mesh_terms: D000497:Alloys; D000818:Animals; D001704:Biopolymers / Q000737:chemistry*; D001842:Bone and Bones; D006801:Humans; D015394:Molecular Structure; D016062:Porosity; D019736:Prostheses and Implants; D013499:Surface Properties; D023822:Tissue Engineering / Q000379:methods*; D054457:Tissue Scaffolds / Q000737:chemistry*; D014025:Titanium / Q000737:chemistry*; D017155:Wettability
chemical_list: D000497:Alloys; D001704:Biopolymers; C031462:titanium alloy (TiAl6V4); D014025:Titanium