title: Liposome solubilization induced by surfactant molecules in a microchip.
abstract: The dynamics of liposome solubilization was monitored by dynamic light scattering and optical microscopy.  A newly designed Y-shape microchannel connected to a room was incorporated into a microchip and the reaction processes of the liposome suspension and surfactant solution were observed in the room after mixing the two fluids and stopping the flow.  By using this microchip, we succeeded in real-time monitoring of liposome solubilization and the following dynamic processes of solubilization were proposed: 1) Deformed liposomes become spherical.  2) The liposome size increases until the surfactant/liposome ratio in the liposome membrane reaches a threshold value.  3) Mixed micelles of surfactants and phospholipids are released and the liposomes collapse.
authors.affiliation: Department of Applied Chemistry, Faculty of Science and Engineering, Chuo University, Tokyo, Japan.
authors.forename: Yuri
authors.initials: Y
authors.lastname: Shoji
authors.forename: Takashi
authors.initials: T
authors.lastname: Igarashi
authors.forename: Hiroko
authors.initials: H
authors.lastname: Nomura
authors.forename: Takeshi
authors.initials: T
authors.lastname: Eitoku
authors.forename: Kenji
authors.initials: K
authors.lastname: Katayama
mesh_terms: D056656:Lab-On-A-Chip Devices; D008027:Light; D008081:Liposomes / Q000737:chemistry*; D008823:Micelles; D046208:Microchip Analytical Procedures / Q000379:methods*; D008853:Microscopy / Q000379:methods; D055095:Optics and Photonics / Q000379:methods; D020113:Phenolphthalein / Q000737:chemistry; D010713:Phosphatidylcholines / Q000737:chemistry; D012542:Scattering, Radiation; D013501:Surface-Active Agents / Q000737:chemistry*; D013997:Time Factors
chemical_list: D008081:Liposomes; D008823:Micelles; D010713:Phosphatidylcholines; D013501:Surface-Active Agents; D020113:Phenolphthalein; C017251:1,2-oleoylphosphatidylcholine