title: Nevoid hyperkeratosis of the areola misinterpreted as mycosis fungoides.
abstract: Nevoid hyperkeratosis of the nipple and areola is a benign condition with fewer than 70 cases reported in the literature. We report a case of unilateral nevoid hyperkeratosis of the areola with intraepidermal lymphocytes that resembled Pautrier's microabscesses on histological examination. This is the third report of mycosis fungoides-like changes in nevoid hyperkeratosis of the nipple and areola. In addition, this is the first case to present immunohistochemical and T-cell gene rearrangement studies of the intraepidermal lymphocytes. This case highlights a potential histopathological pitfall in the diagnosis of nevoid hyperkeratosis of the nipple and areola.
authors.affiliation: Division of Dermatology, Washington University School of Medicine, St. Louis, MO, USA.
authors.forename: Ilana S
authors.initials: IS
authors.lastname: Rosman
authors.forename: Donna M
authors.initials: DM
authors.lastname: Hepper
authors.forename: Anne C
authors.initials: AC
authors.lastname: Lind
authors.forename: Milan J
authors.initials: MJ
authors.lastname: Anadkat
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000473:pathology*; D003937:Diagnosis, Differential; D004817:Epidermis / Q000473:pathology; D005260:Female; D006801:Humans; D007642:Keratosis / Q000473:pathology*; D009182:Mycosis Fungoides / Q000473:pathology*; D009558:Nipples / Q000473:pathology; D013601:T-Lymphocytes / Q000473:pathology