title: Acute lymphocytic leukemia with eosinophilia: a case report and review of the literature.
abstract: We present a 61-year-old man with marked peripheral blood eosinophilia, feature of hypereosinophilic syndrome, that later evolved into acute lymphocytic leukemia (ALL-L2). Initially the patient suffered from significant complications related to eosinophilic toxicity, including large urticarial hyperpigmented plaques, myocardial infarction, and eosinophilic pneumonia. He was treated with high dose of steroids resulting in a rapid suppression of the eosinophilia. Two weeks later, the eosinophilia had relapsed, so a bone marrow aspiration was performed. Cytomorphological examination of the bone marrow showed typical ALL features, while flow cytometric analysis revealed an My+pre-B-ALL immunophenotype, and chromosome analysis of bone marrow showed a normal karyotype. He received chemotherapy according to the standard protocol for ALL and died from refractory respiratory failure and congestive heart failure immediately after antileukemic therapy. We review the literature and compare the demographics, clinical features, and outcomes of several cases and reported studies.
authors.affiliation: Department of Hematology, Affiliated Hospital of Nantong University, Nantong, China.
authors.forename: Guoqi
authors.initials: G
authors.lastname: Song
authors.forename: Hong
authors.initials: H
authors.lastname: Liu
authors.forename: Feng
authors.initials: F
authors.lastname: Sun
authors.forename: Ling
authors.initials: L
authors.lastname: Gu
authors.forename: Shukui
authors.initials: S
authors.lastname: Wang
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001853:Bone Marrow / Q000473:pathology; D003937:Diagnosis, Differential; D004802:Eosinophilia / Q000150:complications* / Q000175:diagnosis*; D017809:Fatal Outcome; D005434:Flow Cytometry; D006333:Heart Failure / Q000150:complications / Q000401:mortality; D006801:Humans; D016130:Immunophenotyping; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000175:diagnosis; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D011657:Pulmonary Eosinophilia / Q000150:complications / Q000628:therapy; D012131:Respiratory Insufficiency / Q000150:complications / Q000401:mortality; D016896:Treatment Outcome