title: From primary progressive aphasia to corticobasal syndrome: two clinical and rCBF functional reports.
abstract: We describe two cases, both presenting with a 2-year history of isolated language disorders, one compatible with logopenic variant and the other with non-fluent variant of primary progressive aphasia (PPA). Afterwards, each developed a corticobasal syndrome (CBS) with alien limb phenomenon and a multi-domain cognitive impairment. Regional cerebral perfusion (rCBF) study using 99mTc-ECD single photon emission computed tomography (SPECT) revealed hypoperfusion patterns consistent with these aphasia types and with the presence of limb apraxia. We report two cases of PPA variants associated with CBS and we suggest that SPECT rCBF correlates can be useful in making a differential diagnosis within the PPA spectrum.
authors.affiliation: Department of Neurology, Scientific Institute and University Vita-Salute San Raffaele, Milan, Italy. caso.francesca@hsr.it
authors.forename: F
authors.initials: F
authors.lastname: Caso
authors.forename: F
authors.initials: F
authors.lastname: Onofrio
authors.forename: M
authors.initials: M
authors.lastname: Falautano
authors.forename: P
authors.initials: P
authors.lastname: Todeschini
authors.forename: R
authors.initials: R
authors.lastname: Migliaccio
authors.forename: G
authors.initials: G
authors.lastname: Comi
authors.forename: D
authors.initials: D
authors.lastname: Perani
authors.forename: G
authors.initials: G
authors.lastname: Magnani
mesh_terms: D000368:Aged; D018888:Aphasia, Primary Progressive / Q000150:complications* / Q000000981:diagnostic imaging; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003072:Cognition Disorders / Q000000981:diagnostic imaging / Q000209:etiology*; D003545:Cysteine / Q000031:analogs & derivatives; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D009483:Neuropsychological Tests; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D012189:Retrospective Studies; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C059659:technetium Tc 99m bicisate; D003545:Cysteine