title: Directing stem cell fate by controlling the affinity and density of ligand-receptor interactions at the biomaterials interface.
abstract: Sticky situation: the differentiation of mesenchymal stem cells can be influenced by the affinity and density of an immobilized ligand for the integrin receptors. Cells adherent to monolayers that present the high-affinity, cyclic-RGD peptide (left) show increased expression of osteogenic markers, while cells on monolayers presenting the lower-affinity, linear-RGD peptide (right) express early markers of myogenesis at a high density and neurogenesis at a low density of the ligand.
authors.affiliation: Department of Chemistry, Northwestern University, USA.
authors.forename: Kristopher A
authors.initials: KA
authors.lastname: Kilian
authors.forename: Milan
authors.initials: M
authors.lastname: Mrksich
mesh_terms: D001672:Biocompatible Materials / Q000378:metabolism / Q000494:pharmacology*; D002448:Cell Adhesion / Q000502:physiology; D018929:Cell Culture Techniques; D002454:Cell Differentiation / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D005455:Fluorescent Antibody Technique; D006801:Humans; D008024:Ligands; D059630:Mesenchymal Stem Cells / Q000166:cytology* / Q000187:drug effects* / Q000378:metabolism; D010455:Peptides; D011485:Protein Binding; D011956:Receptors, Cell Surface / Q000378:metabolism*
chemical_list: D001672:Biocompatible Materials; D008024:Ligands; D010455:Peptides; D011956:Receptors, Cell Surface