title: Pathogen free conditions slow the onset of neurodegeneration in a mouse model of nerve growth factor deprivation.
abstract: Several studies suggest that systemic infection occurring during aging and chronic neurodegenerative diseases can evoke an exaggerated immune response that contributes to the progression of neurodegeneration and cognitive decline. However, studies directly addressing the relationship between microbial environment and the onset of neurodegeneration in Alzheimer's disease animal models are lacking. Here we show that the onset of neurodegeneration that transgenic mice develop when raised in conventional husbandry slows down when raising anti-nerve growth factor transgenic mice in a murine pathogen free condition.
authors.affiliation: Laboratory of Neurobiology, Scuola Normale Superiore, Pisa, Italy. simona.capsoni@sns.it
authors.forename: Simona
authors.initials: S
authors.lastname: Capsoni
authors.forename: Nicola Maria
authors.initials: NM
authors.lastname: Carucci
authors.forename: Antonino
authors.initials: A
authors.lastname: Cattaneo
mesh_terms: D000818:Animals; D017250:Caliciviridae Infections / Q000150:complications; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D003072:Cognition Disorders / Q000209:etiology; D004195:Disease Models, Animal; D018450:Disease Progression; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D008070:Lipopolysaccharides / Q000633:toxicity; D051379:Mice; D008822:Mice, Transgenic; D020932:Nerve Growth Factor / Q000172:deficiency*; D019636:Neurodegenerative Diseases / Q000097:blood / Q000150:complications* / Q000209:etiology* / Q000473:pathology; D029322:Norovirus / Q000472:pathogenicity; D014245:Trichomonas Infections / Q000150:complications; D016875:tau Proteins / Q000378:metabolism
chemical_list: D015850:Interleukin-6; D008070:Lipopolysaccharides; D016875:tau Proteins; D020932:Nerve Growth Factor; D002795:Choline O-Acetyltransferase