title: Fine control of polyester properties via epoxide ROP using monomers carrying diverse functional groups.
abstract: Synthetic biodegradable polymers are important biomaterials. However, most of them are biologically inert. Free functional groups can allow easy biofunctionalization. Efficient introduction of functional groups to biodegradable polymers is still a challenge. Here, a practical strategy is presented to synthesize various functional polyesters with free hydroxyl groups polymerized via epoxide ring-opening polymerization between dicarboxylic acids and diglycidyl dicarboxylates without protection and deprotection. The polymers exhibit a wide range of physical, thermal, and mechanical properties, and good cytocompatibilities. This synthetic platform is expected to lead to functional polymers useful for a wide variety of biomedical applications.
authors.affiliation: Departments of Bioengineering and Surgery, and the McGowan Institute, University of Pittsburgh, 3700 O'Hara Street, Pittsburgh, PA 15261, USA.
authors.forename: Zhengwei
authors.initials: Z
authors.lastname: You
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Bi
authors.forename: Yadong
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000818:Animals; D003998:Dicarboxylic Acids / Q000737:chemistry*; D004852:Epoxy Compounds / Q000737:chemistry*; D008422:Materials Testing; D051379:Mice; D041681:NIH 3T3 Cells; D011091:Polyesters / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology
chemical_list: D003998:Dicarboxylic Acids; D004852:Epoxy Compounds; D011091:Polyesters