title: Longitudinal investigation of the impact of anxiety and mood disorders in adolescence on subsequent substance use disorder onset and vice versa.
abstract: OBJECTIVE
  A large body of epidemiological research indicates that anxiety and mood disorders are highly comorbid with substance use disorders (SUDs). However, longitudinal research regarding their temporal relations is limited. The goal of this study was to assess whether emotional disorders (i.e., anxiety and mood disorders) predict the onset of SUDs, whether SUDs predict the onset of emotional disorders, or both.
  
  
  METHODS
  The current study used data from baseline assessment (N=627) and four years of follow-up assessments from the NU/UCLA Youth Emotion Project to examine this question.
  
  
  RESULTS
  In line with the self-medication hypothesis of emotional disorder/SUDs comorbidity, anxiety and unipolar mood disorders at baseline assessment were associated with later onsets of SUDs. In particular, social anxiety disorder (SAD) at baseline predicted onset of alcohol use disorders and PTSD predicted the onset of all SUDs. SUDs did not predict any anxiety or unipolar mood disorders with the exception that alcohol use disorders predicted the onset of obsessive compulsive disorder (OCD).
  
  
  CONCLUSIONS
  These findings, as well as the clinical implications and future directions for research, are discussed.
authors.affiliation: UCLA Department of Psychology, University of California-Los Angeles, 405 Hilgard Ave., LosAngeles, CA 90024, United States.
authors.forename: Kate
authors.initials: K
authors.lastname: Wolitzky-Taylor
authors.forename: Lyuba
authors.initials: L
authors.lastname: Bobova
authors.forename: Richard E
authors.initials: RE
authors.lastname: Zinbarg
authors.forename: Susan
authors.initials: S
authors.lastname: Mineka
authors.forename: Michelle G
authors.initials: MG
authors.lastname: Craske
mesh_terms: D000293:Adolescent; D000294:Adolescent Behavior / Q000523:psychology; D001008:Anxiety Disorders / Q000453:epidemiology / Q000523:psychology*; D002641:Chicago / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008137:Longitudinal Studies; D015141:Los Angeles / Q000453:epidemiology; D008297:Male; D019964:Mood Disorders / Q000453:epidemiology / Q000523:psychology*; D012307:Risk Factors; D019966:Substance-Related Disorders / Q000453:epidemiology / Q000523:psychology*