title: Nasopharyngeal lactate dehydrogenase concentrations predict bronchiolitis severity in a prospective multicenter emergency department study.
abstract: We reexamined the finding of an inverse relationship between values of nasopharyngeal lactate dehydrogenase, a marker of the innate immune response, and bronchiolitis severity. In a prospective, multicenter study of 258 children, we found in a multivariable model that higher nasopharyngeal lactate dehydrogenase values in young children with bronchiolitis were independently associated with a decreased risk of hospitalization.
authors.affiliation: Department of Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA. jonathan.mansbach@childrens.harvard.edu
authors.forename: Jonathan M
authors.initials: JM
authors.lastname: Mansbach
authors.forename: Pedro A
authors.initials: PA
authors.lastname: Piedra
authors.forename: Federico R
authors.initials: FR
authors.lastname: Laham
authors.forename: Alexander J
authors.initials: AJ
authors.lastname: McAdam
authors.forename: Sunday
authors.initials: S
authors.lastname: Clark
authors.forename: Ashley F
authors.initials: AF
authors.lastname: Sullivan
authors.forename: Carlos A
authors.initials: CA
authors.lastname: Camargo
mesh_terms: D001988:Bronchiolitis / Q000175:diagnosis* / Q000473:pathology*; D015331:Cohort Studies; D004635:Emergency Medicine / Q000379:methods; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007770:L-Lactate Dehydrogenase / Q000032:analysis*; D008297:Male; D009305:Nasopharynx / Q000201:enzymology*; D011379:Prognosis; D011446:Prospective Studies; D012720:Severity of Illness Index; D013223:Statistics as Topic
chemical_list: D007770:L-Lactate Dehydrogenase