title: Validation of diffuse correlation spectroscopic measurement of cerebral blood flow using phase-encoded velocity mapping magnetic resonance imaging.
abstract: Diffuse correlation spectroscopy (DCS) is a novel optical technique that appears to be an excellent tool for assessing cerebral blood flow in a continuous and non-invasive manner at the bedside. We present new clinical validation of the DCS methodology by demonstrating strong agreement between DCS indices of relative cerebral blood flow and indices based on phase-encoded velocity mapping magnetic resonance imaging (VENC MRI) of relative blood flow in the jugular veins and superior vena cava. Data were acquired from 46 children with single ventricle cardiac lesions during a hypercapnia intervention. Significant increases in cerebral blood flow, measured both by DCS and by VENC MRI, as well as significant increases in oxyhemoglobin concentration, and total hemoglobin concentration, were observed during hypercapnia. Comparison of blood flow changes measured by VENC MRI in the jugular veins and by DCS revealed a strong linear relationship, R=0.88, p<0.001, slope=0.91±0.07. Similar correlations were observed between DCS and VENC MRI in the superior vena cava, R=0.77, slope=0.99±0.12, p<0.001. The relationship between VENC MRI in the aorta and DCS, a negative control, was weakly correlated, R=0.46, slope=1.77±0.45, p<0.001.
authors.affiliation: University of Pennsylvania, Department of Physics and Astronomy, 3231 Walnut Street, Philadelphia, Pennsylvania 19104, USA. ebuckle2@sas.upenn.edu
authors.forename: Erin M
authors.initials: EM
authors.lastname: Buckley
authors.forename: Dalton
authors.initials: D
authors.lastname: Hance
authors.forename: Thomas
authors.initials: T
authors.lastname: Pawlowski
authors.forename: Jennifer
authors.initials: J
authors.lastname: Lynch
authors.forename: Felice B
authors.initials: FB
authors.lastname: Wilson
authors.forename: Rickson C
authors.initials: RC
authors.lastname: Mesquita
authors.forename: Turgut
authors.initials: T
authors.lastname: Durduran
authors.forename: Laura K
authors.initials: LK
authors.lastname: Diaz
authors.forename: Mary E
authors.initials: ME
authors.lastname: Putt
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Licht
authors.forename: Mark A
authors.initials: MA
authors.lastname: Fogel
authors.forename: Arjun G
authors.initials: AG
authors.lastname: Yodh
mesh_terms: D001011:Aorta / Q000502:physiology; D001784:Blood Gas Analysis; D002245:Carbon Dioxide / Q000097:blood; D002560:Cerebrovascular Circulation / Q000502:physiology*; D002675:Child, Preschool; D004058:Diffusion; D005260:Female; D006330:Heart Defects, Congenital / Q000601:surgery; D006801:Humans; D006935:Hypercapnia / Q000503:physiopathology; D007223:Infant; D007601:Jugular Veins / Q000502:physiology; D016014:Linear Models; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D010108:Oxyhemoglobins / Q000737:chemistry; D015203:Reproducibility of Results; D013057:Spectrum Analysis / Q000379:methods*; D018709:Statistics, Nonparametric; D014683:Vena Cava, Superior / Q000502:physiology
chemical_list: D010108:Oxyhemoglobins; D002245:Carbon Dioxide