title: Primary sellar neuroblastoma. A new case and review of literature.
abstract: The primary intracranial development of olfactory neuroblastomas, outside olfactory epithelium, is rare. We report a case of primary sellar neuroblastoma without any aggressive histopathological features, managed solely surgically without adjuvant therapy, with good outcomes at 3 years. Primary sellar neuroblastomas mostly occur in women in the 4th decade with a context of a non-secreting pituitary tumour. Diagnosis is made on histopathological examination (small cells, fibrillary intercellular background, strong immunoreactivity for neurons markers, negative immunoreactivity for anterior pituitary hormones). Management is based on surgery. Adjuvant treatment is not consensual, largely depends on patient's conditions and aggressive histopathological features.
authors.affiliation: Service de neurochirurgie, centre hospitalo-universitaire Rangueil, 1, avenue du Pr-Jean-Poulhès, TSA 50032, 31059 Toulouse cedex, France. martindupuy@yahoo.fr
authors.forename: Martin
authors.initials: M
authors.lastname: Dupuy
authors.forename: Fabrice
authors.initials: F
authors.lastname: Bonneville
authors.forename: Solange
authors.initials: S
authors.lastname: Grunenwald
authors.forename: Florence
authors.initials: F
authors.lastname: Breibach
authors.forename: Marie-Bernadette
authors.initials: MB
authors.lastname: Delisle
authors.forename: Patrick
authors.initials: P
authors.lastname: Chaynes
authors.forename: Jean-Christophe
authors.initials: JC
authors.lastname: Sol
authors.forename: Philippe
authors.initials: P
authors.lastname: Caron
mesh_terms: D019797:3-Iodobenzylguanidine; D000236:Adenoma / Q000175:diagnosis; D000328:Adult; D000568:Amenorrhea / Q000209:etiology; D014408:Biomarkers, Tumor; D003937:Diagnosis, Differential; D018304:Esthesioneuroblastoma, Olfactory / Q000737:chemistry / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000209:etiology; D007016:Hypophysectomy; D007177:Inappropriate ADH Syndrome / Q000209:etiology*; D007457:Iodine Radioisotopes; D008279:Magnetic Resonance Imaging; D009363:Neoplasm Proteins / Q000032:analysis; D010911:Pituitary Neoplasms / Q000175:diagnosis; D011379:Prognosis; D019275:Radiopharmaceuticals; D012074:Remission Induction; D012658:Sella Turcica; D015173:Supratentorial Neoplasms / Q000737:chemistry / Q000150:complications / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D014786:Vision Disorders / Q000209:etiology; D051598:Whole Body Imaging
chemical_list: D014408:Biomarkers, Tumor; D007457:Iodine Radioisotopes; D009363:Neoplasm Proteins; D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine