title: Pathways of ion-molecular interactions of nucleogenic phenyl cations with the nucleophilic centers of picolines.
abstract: BACKGROUND
  The nuclear-chemical method brought unique opportunity for synthesis of unknown and hardly available organic compounds. Presence of tritium labeling allows one-step preparation of radioactive markers for the investigation of chemical and biological processes.
  
  
  METHODS
  The ion-molecular reactions of nucleogenic phenyl cations with 4-picoline have been carried out. The phenyl cations were generated by spontaneous tritium β-decay within the tritium-labeled benzene. Both additions to the nitrogen and substitutions about the aromatic ring were able to be studied simultaneously.
  
  
  RESULTS
  Unusual substitutions on both the α- and β-positions of the ring system have been revealed.
  
  
  CONCLUSIONS
  By unknown direct phenylation of nitrogen atom tritium-labeled N-phenylpicolinium derivatives, perspective biological markers have been synthesized.
authors.affiliation: Laboratory of Radiochemistry, Natural Sciences Institute of Perm State University, 4 Genkel St, Perm 614990, Russia. neshchepina@mail.ru.
authors.forename: Nadezhda E
authors.initials: NE
authors.lastname: Shchepina
authors.forename: Viktor V
authors.initials: VV
authors.lastname: Avrorin
authors.forename: Gennady A
authors.initials: GA
authors.lastname: Badun
authors.forename: Nikolay A
authors.initials: NA
authors.lastname: Bumagin
authors.forename: Scott B
authors.initials: SB
authors.lastname: Lewis
authors.forename: Sergey N
authors.initials: SN
authors.lastname: Shurov