title: [Acute myocarditis].
abstract: Myocarditis is defined as inflammation of the myocardium accompanied by myocellular necrosis. Acute myocarditis must be considered in patients who present with recent-onset of cardiac failure or arrhythmia. Fulminant myocarditis is a distinct entity characterized by sudden onset of severe congestive heart failure or cardiogenic shock, usually following a flu-like illness, parvovirus B19, human herpesvirus 6, coxsackievirus and adenovirus being the most frequently viruses responsible for the disease. Treatment of myocarditis remains largely supportive, since immunosuppression has not been proven to be beneficial for acute lymphocytic myocarditis. Trials of antiviral therapies, or immunostimulants such as interferons, suggest a potential therapeutic role but require further investigation. Lastly, early recognition of patients rapidly progressing to refractory cardiac failure and their immediate transfer to a medical-surgical center experienced in mechanical circulatory support is warranted. In this setting, ECMO should be the first-line mechanical assistance. For highly unstable patients, a Mobile Cardiac Assistance Unit, that rapidly travels to primary care hospitals with a portable ECMO system and hooks it up before refractory multiorgan failure takes hold, is the preferred option.
authors.affiliation: Hôpital Pitié-Salpêtrière, Assistance publique-Hôpitaux de Paris, service de réanimation médicale, 75651 Paris cedex 13, France. alain.combes@psl.aphp.fr
authors.forename: Alain
authors.initials: A
authors.lastname: Combes
mesh_terms: D000208:Acute Disease; D004452:Echocardiography; D015199:Extracorporeal Membrane Oxygenation; D006321:Heart / Q000503:physiopathology*; D006333:Heart Failure / Q000628:therapy*; D006801:Humans; D009205:Myocarditis / Q000150:complications* / Q000188:drug therapy / Q000628:therapy; D009206:Myocardium / Q000473:pathology*; D011379:Prognosis; D012770:Shock, Cardiogenic / Q000628:therapy*; D016896:Treatment Outcome