title: [Effects of CVB-D on hemodynamic in anaesthetized dogs in vivo].
abstract: OBJECTIVE
  To investigate hemodynamic in anaesthetized dogs after the intravenous injection of cyclovirobuxine D (CVB-D).
  
  
  METHODS
  The hemodynamic of anaesthetized dogs were observed after intravenous injection of CVB-D at doses of 0.1, 0.2, 0.4 mg/kg.
  
  
  RESULTS
  CVB-D of 0.2 and 0.4 mg/kg could decrease HR, TPVR and increase CBF. In addition, CVB-D of 0.4 mg/kg could increase SAP and SV. Yet MAP and CO of dogs showed no remarkable changes with the treatment of CVB-D.
  
  
  CONCLUSIONS
  CVB-D has effect of improving cardiac function, which may be the mechanism of anti-myocardial ischemia effect of CVB-D.
authors.affiliation: Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica, Nanjing University of TCM, Nanjing 200046, China. yubinruming@sina.com
authors.forename: Bin
authors.initials: B
authors.lastname: Yu
authors.forename: Ming
authors.initials: M
authors.lastname: Ruan
authors.forename: Xiang-Chun
authors.initials: XC
authors.lastname: Shen
authors.forename: Li
authors.initials: L
authors.lastname: Xu
authors.forename: Hong
authors.initials: H
authors.lastname: Zheng
authors.forename: Tai-Hui
authors.initials: TH
authors.lastname: Fang
mesh_terms: D000758:Anesthesia; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D031235:Buxus / Q000737:chemistry; D002302:Cardiac Output / Q000187:drug effects; D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D003326:Coronary Circulation / Q000187:drug effects; D004285:Dogs; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D007275:Injections, Intravenous; D008297:Male; D011897:Random Allocation; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D002316:Cardiotonic Agents; D004365:Drugs, Chinese Herbal; C032939:cyclovirobuxine D