title: Solvent effect on copper-catalyzed azide-alkyne cycloaddition (CuAAC): synthesis of novel triazolyl substituted quinolines as potential anticancer agents.
abstract: A regioselective route to novel mono triazolyl substituted quinolines has been developed via copper-catalyzed azide-alkyne cycloaddition (CuAAC) of 2,4-diazidoquinoline with terminal alkynes in DMF. The reaction provided bis triazolyl substituted quinolines when performed in water in the presence of Et(3)N. A number of the compounds synthesized showed promising anti-proliferative properties when tested in vitro especially against breast cancer cells.
authors.affiliation: Chemistry-Technology Development Center, Dr. Reddy's Laboratories Limited, Miyapur, Hyderabad, Andhra Pradesh, India.
authors.forename: Amarender Reddy
authors.initials: AR
authors.lastname: Ellanki
authors.forename: Aminul
authors.initials: A
authors.lastname: Islam
authors.forename: Veera Swamy
authors.initials: VS
authors.lastname: Rama
authors.forename: Ranga Prasad
authors.initials: RP
authors.lastname: Pulipati
authors.forename: D
authors.initials: D
authors.lastname: Rambabu
authors.forename: G Rama
authors.initials: GR
authors.lastname: Krishna
authors.forename: C Malla
authors.initials: CM
authors.lastname: Reddy
authors.forename: K
authors.initials: K
authors.lastname: Mukkanti
authors.forename: G R
authors.initials: GR
authors.lastname: Vanaja
authors.forename: Arunasree M
authors.initials: AM
authors.lastname: Kalle
authors.forename: K Shiva
authors.initials: KS
authors.lastname: Kumar
authors.forename: Manojit
authors.initials: M
authors.lastname: Pal
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D001386:Azides / Q000737:chemistry*; D045744:Cell Line, Tumor; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008958:Models, Molecular; D011804:Quinolines / Q000737:chemistry*; D012997:Solvents / Q000737:chemistry*
chemical_list: D000480:Alkynes; D000970:Antineoplastic Agents; D001386:Azides; D011804:Quinolines; D012997:Solvents; D003300:Copper