title: Angiotensin-converting enzyme inhibitors in the perioperative period.
abstract: Angiotensin-converting enzyme (ACE) inhibitors inhibit the enzyme that cleaves angiotensin I to form angiotensin II. They are potent vasodilators as they decrease concentrations of angiotensin II and noradrenaline and increase concentrations of bradykinin and nitric oxide. They reduce secretion of aldosterone and antidiuretic hormone, thus reducing salt and water reabsorption by the kidney (Groban and Butterworth, 2006).
authors.affiliation: Department of Anaesthesia, Manchester Royal Infirmary, Manchester M13 9WL. croftrachael@hotmail.com
authors.forename: Rachael
authors.initials: R
authors.lastname: Croft
authors.forename: Greg
authors.initials: G
authors.lastname: Cook
authors.forename: Stephen
authors.initials: S
authors.lastname: Washington
mesh_terms: D000768:Anesthesia, General / Q000009:adverse effects; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects* / Q000494:pharmacology; D006801:Humans; D007022:Hypotension / Q000139:chemically induced*; D007431:Intraoperative Complications / Q000139:chemically induced*; D059035:Perioperative Period; D012084:Renin-Angiotensin System / Q000187:drug effects; D056737:Safety-Based Drug Withdrawals
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors