title: Chicken-based formula is better tolerated than extensively hydrolyzed casein formula for the management of cow milk protein allergy in infants.
abstract: The effective treatment of cow milk allergy in infants consists of elimination of cow milk protein and the introduction of formulas based on an extensively hydrolyzed protein formula or an amino acid-based formula. However, about 10% of these infants are still allergic to an extensively hydrolyzed protein formula and an amino acid-based formula is very expensive. We conducted a study to verify whether the new chicken-based formula will be better tolerated than an extensively hydrolyzed protein formula for the treatment of cow milk allergy in infants. One hundred infants, diagnosed with cow milk allergy by double-blind, placebo-controlled food challenge tests, were enrolled in a double-blind, randomized, cross-over study to compare a response to an extensively hydrolyzed protein formula and the chicken-based formula. Subjects were randomly given one of the two formulas for 2 weeks. There was a 2-week washout period of taking an amino acid-based formula before being switched to the other formula for another 2 weeks. If the subjects showed allergic symptoms during the 2 weeks of test formula, they would be announced as intolerance or allergic to that formula. Sixty seven of 80 confirmed subjects agreed to enroll their infants. Fifty-eight subjects completed the study. Twenty and 33 infants were tolerant whereas and 38 and 25 infants were intolerant to an extensively hydrolyzed protein formula and the chicken-based formula, respectively. The chicken-based formula showed significantly better tolerance than an extensively hydrolyzed protein formula in the management of cow milk allergy in infants.
authors.affiliation: Department of Pediatrics, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkoknoi, Bangkok, Thailand. sipjr@mahidol.ac.th
authors.forename: Pipop
authors.initials: P
authors.lastname: Jirapinyo
authors.forename: Narumon
authors.initials: N
authors.lastname: Densupsoontorn
authors.forename: Channagan
authors.initials: C
authors.lastname: Kangwanpornsiri
authors.forename: Renu
authors.initials: R
authors.lastname: Wongarn
mesh_terms: D000596:Amino Acids / Q000009:adverse effects / Q000378:metabolism; D000818:Animals; D002364:Caseins / Q000009:adverse effects / Q000378:metabolism; D002417:Cattle; D002645:Chickens / Q000378:metabolism*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D005518:Food Preferences; D006801:Humans; D007223:Infant; D041943:Infant Formula / Q000737:chemistry* / Q000378:metabolism; D008297:Male; D016269:Milk Hypersensitivity / Q000178:diet therapy* / Q000208:ethnology / Q000378:metabolism; D008894:Milk Proteins / Q000009:adverse effects / Q000378:metabolism; D009124:Muscle Proteins / Q000009:adverse effects / Q000378:metabolism*; D010352:Patient Dropouts; D011492:Protein Hydrolysates / Q000009:adverse effects / Q000378:metabolism; D013785:Thailand
chemical_list: D000596:Amino Acids; D002364:Caseins; D008894:Milk Proteins; D009124:Muscle Proteins; D011492:Protein Hydrolysates