title: A case report of primary small cell carcinoma of the breast and review of the literature.
abstract: Primary small cell carcinoma (SCC) of the breast, an exceedingly rare and aggressive tumor, is often characterized by rapid progression and poor prognosis. We report a case of primary SCC of the breast that was diagnosed through pathologic and immunohistochemical examinations. Computed tomography (CT) scans failed to reveal a non-mammary primary site. Due to the scant number of relevant case summaries, this type of tumor is proved to be a diagnostic and therapeutic challenge. Therefore, we also reviewed relevant literature to share expertise in diagnosis, clinicopathologic characteristics, treatment, and prognosis of this type of tumor. Future studies with more cases are required to define more appropriate treatment indications for this disease.
authors.affiliation: Department of Breast Oncology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, People's Republic of China. weiweid@mail.sysu.edu.cn
authors.forename: Qi-Dong
authors.initials: QD
authors.lastname: Ge
authors.forename: Ning
authors.initials: N
authors.lastname: Lv
authors.forename: Yun
authors.initials: Y
authors.lastname: Cao
authors.forename: Xi
authors.initials: X
authors.lastname: Wang
authors.forename: Jun
authors.initials: J
authors.lastname: Tang
authors.forename: Ze-Ming
authors.initials: ZM
authors.lastname: Xie
authors.forename: Xiang-Sheng
authors.initials: XS
authors.lastname: Xiao
authors.forename: Peng
authors.initials: P
authors.lastname: Liu
authors.forename: Xiao-Ming
authors.initials: XM
authors.lastname: Xie
authors.forename: Wei-Dong
authors.initials: WD
authors.lastname: Wei
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D019002:CD56 Antigen / Q000378:metabolism; D016190:Carboplatin / Q000008:administration & dosage; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D018288:Carcinoma, Small Cell / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D000077143:Docetaxel; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008327:Mammography; D009687:Nuclear Proteins / Q000378:metabolism; D010751:Phosphopyruvate Hydratase / Q000378:metabolism; D016708:Synaptophysin / Q000378:metabolism; D043823:Taxoids / Q000008:administration & dosage; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors / Q000378:metabolism; D014463:Ultrasonography
chemical_list: D019002:CD56 Antigen; D009687:Nuclear Proteins; D016708:Synaptophysin; D043823:Taxoids; D000074482:Thyroid Nuclear Factor 1; D014157:Transcription Factors; D000077143:Docetaxel; D016190:Carboplatin; D010751:Phosphopyruvate Hydratase