title: Estimating the genetic variance of major depressive disorder due to all single nucleotide polymorphisms.
abstract: Genome-wide association studies of psychiatric disorders have been criticized for their lack of explaining a considerable proportion of the heritability established in twin and family studies. Genome-wide association studies of major depressive disorder in particular have so far been unsuccessful in detecting genome-wide significant single nucleotide polymorphisms (SNPs). Using two recently proposed methods designed to estimate the heritability of a phenotype that is attributable to genome-wide SNPs, we show that SNPs on current platforms contain substantial information concerning the additive genetic variance of major depressive disorder. To assess the consistency of these two methods, we analyzed four other complex phenotypes from different domains. The pattern of results is consistent with estimates of heritability obtained in twin studies carried out in the same population.
authors.affiliation: Department of Psychology, University of Notre Dame, Notre Dame, IN 46556, USA. glubke@nd.edu
authors.forename: Gitta H
authors.initials: GH
authors.lastname: Lubke
authors.forename: Jouke Jan
authors.initials: JJ
authors.lastname: Hottenga
authors.forename: Raymond
authors.initials: R
authors.lastname: Walters
authors.forename: Charles
authors.initials: C
authors.lastname: Laurin
authors.forename: Eco J C
authors.initials: EJ
authors.lastname: de Geus
authors.forename: Gonneke
authors.initials: G
authors.lastname: Willemsen
authors.forename: Jan H
authors.initials: JH
authors.lastname: Smit
authors.forename: Christel M
authors.initials: CM
authors.lastname: Middeldorp
authors.forename: Brenda W J H
authors.initials: BW
authors.lastname: Penninx
authors.forename: Jacqueline M
authors.initials: JM
authors.lastname: Vink
authors.forename: Dorret I
authors.initials: DI
authors.lastname: Boomsma
mesh_terms: D003865:Major Depressive Disorder / Q000175:diagnosis / Q000235:genetics*; D005215:Fasting; D005260:Female; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation / Q000235:genetics*; D055106:Genome-Wide Association Study; D005838:Genotype; D005947:Glucose; D006801:Humans; D008297:Male; D015233:Models, Statistical; D009426:Netherlands; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D012907:Smoking / Q000235:genetics; D018433:Twin Studies as Topic
chemical_list: D005947:Glucose