title: Left ventricular assist device as bridge to recovery for anthracycline-induced terminal heart failure.
abstract: Anthracycline treatments are hampered by dose-related cardiotoxicity, frequently leading to heart failure (HF) with a very poor prognosis. The authors report a case of a 19-year-old man developing HF after anthracycline treatment for Ewing sarcoma. Despite medical treatment, his condition deteriorated to terminal HF, leading to implantation of a mechanical left ventricular assist device (LVAD). His heart function recovered, allowing explantation of the device 14 months after implantation. Heart transplantation is often contraindicated in the first years after treatment for cancers, and LVAD as "bridge to recovery" may be warranted in similar patients.
authors.affiliation: Departments of CardiologyThoracic Surgery Thoracic Anesthesiology Oncology, Rigshopitalet, Copenhagen, Denmark. jon.michael.appel@gmail.com
authors.forename: Jon M
authors.initials: JM
authors.lastname: Appel
authors.forename: Kåre
authors.initials: K
authors.lastname: Sander
authors.forename: Peter B
authors.initials: PB
authors.lastname: Hansen
authors.forename: Jacob E
authors.initials: JE
authors.lastname: Møller
authors.forename: Anders
authors.initials: A
authors.lastname: Krarup-Hansen
authors.forename: Finn
authors.initials: F
authors.lastname: Gustafsson
mesh_terms: D018943:Anthracyclines / Q000009:adverse effects*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D054715:Cardiotoxins / Q000009:adverse effects; D006333:Heart Failure / Q000139:chemically induced / Q000473:pathology / Q000628:therapy*; D016027:Heart Transplantation; D006352:Heart Ventricles / Q000294:innervation* / Q000473:pathology; D006353:Heart-Assist Devices; D006801:Humans; D008297:Male; D055815:Young Adult
chemical_list: D018943:Anthracyclines; D000970:Antineoplastic Agents; D054715:Cardiotoxins