title: Regulation of ATP production by mitochondrial Ca(2+).
abstract: Stimulation of mitochondrial oxidative metabolism by Ca(2+) is now generally recognised as important for the control of cellular ATP homeostasis. Here, we review the mechanisms through which Ca(2+) regulates mitochondrial ATP synthesis. We focus on cardiac myocytes and pancreatic β-cells, where tight control of this process is likely to play an important role in the response to rapid changes in workload and to nutrient stimulation, respectively. We also describe a novel approach for imaging the Ca(2+)-dependent regulation of ATP levels dynamically in single cells.
authors.affiliation: Section of Cell Biology, Division of Diabetes Endocrinology and Metabolism, Department of Medicine, Imperial College London, SW7 2AZ, London, UK.
authors.forename: Andrei I
authors.initials: AI
authors.lastname: Tarasov
authors.forename: Elinor J
authors.initials: EJ
authors.lastname: Griffiths
authors.forename: Guy A
authors.initials: GA
authors.lastname: Rutter
mesh_terms: D000255:Adenosine Triphosphate / Q000096:biosynthesis*; D002118:Calcium / Q000378:metabolism*; D004798:Enzymes / Q000378:metabolism; D006801:Humans; D050417:Insulin-Secreting Cells / Q000378:metabolism; D008928:Mitochondria / Q000201:enzymology / Q000378:metabolism*; D032383:Myocytes, Cardiac / Q000378:metabolism
chemical_list: D004798:Enzymes; D000255:Adenosine Triphosphate; D002118:Calcium