title: MicroRNA-193b modulates proliferation, migration, and invasion of non-small cell lung cancer cells.
abstract: MicroRNAs have been reported to be closely related to the development of human lung cancers. However, the functions of microRNAs in non-small cell lung cancer (NSCLC) remain largely undefined. Here, we investigated the role of microRNA-193b (miR-193b) in NSCLC. Our data showed that miR-193b was markedly down-regulated in NSCLC cancer tissues compared with adjacent normal tissues. The NSCLC cell line (A549) transfected with the miR-193b exhibited significantly decreased proliferation, migration, and invasion capacities when compared with the control cells. In contrast, inhibition of miR-193b increased the proliferation, migration, and invasion of A549 cells. Moreover, miR-193b repressed the expressions of cyclin D1 and urokinase-type plasminogen activator in A549 cells. These data suggest that miR-193b is a tumor suppressor in NSCLC.
authors.affiliation: College of Life Science, China Jiliang University, Hangzhou, China. biohhj@gmail.com
authors.forename: Huajun
authors.initials: H
authors.lastname: Hu
authors.forename: Shangao
authors.initials: S
authors.lastname: Li
authors.forename: Jun
authors.initials: J
authors.lastname: Liu
authors.forename: Bin
authors.initials: B
authors.lastname: Ni
mesh_terms: D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism / Q000473:pathology*; D045744:Cell Line, Tumor; D002465:Cell Movement; D049109:Cell Proliferation / Q000187:drug effects*; D019938:Cyclin D1 / Q000096:biosynthesis; D015536:Down-Regulation; D059585:G1 Phase Cell Cycle Checkpoints; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism / Q000473:pathology*; D035683:MicroRNAs / Q000096:biosynthesis / Q000502:physiology*; D009361:Neoplasm Invasiveness; D014568:Urokinase-Type Plasminogen Activator / Q000096:biosynthesis
chemical_list: C530104:CCND1 protein, human; C546818:MIRN193 microRNA, human; D035683:MicroRNAs; D019938:Cyclin D1; D014568:Urokinase-Type Plasminogen Activator