title: Increased expression of NOR-1 mRNA in the skeletal muscles of cold-exposed neonatal chicks.
abstract: Nuclear receptor subfamily 4, group A (NR4A) subgroup orphan receptors are rapidly induced by various physiological stimuli and have been suggested to regulate oxidative metabolism and muscle mass in mammalian skeletal muscle. The results showed that the NR4A subgroup orphan receptor, NOR-1 (NR4A3), was acutely increased in skeletal muscles of neonatal chicks in response to short-term cold exposure. The increased NOR-1 gene expression was concomitant with cold-induced changes in gene expression of both myostatin and proliferator-activated receptor-gamma coactivator-1 (PGC-1α), and the increase in skeletal muscle mass. These observations suggest that NOR-1 might play a role in controlling skeletal muscle growth in cold-exposed neonatal chicks.
authors.affiliation: Graduate School of Life and Environmental Sciences, University of Tsukuba, Ibaraki, Japan. ijiri@chem.agri.kagohisma-u.ac.jp
authors.forename: Daichi
authors.initials: D
authors.lastname: Ijiri
authors.forename: Tomoko
authors.initials: T
authors.lastname: Matsubara
authors.forename: Yukio
authors.initials: Y
authors.lastname: Kanai
authors.forename: Miho
authors.initials: M
authors.lastname: Hirabayashi
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002645:Chickens / Q000502:physiology*; D003080:Cold Temperature; D005786:Gene Expression Regulation; D018482:Muscle, Skeletal / Q000737:chemistry*; D057105:Nuclear Receptor Subfamily 4, Group A, Member 1 / Q000032:analysis* / Q000235:genetics; D012333:RNA, Messenger / Q000032:analysis
chemical_list: D057105:Nuclear Receptor Subfamily 4, Group A, Member 1; D012333:RNA, Messenger