title: Curing diabetes with transplantation?
abstract: Type 1 diabetes affects >1 million people in the United States, where it accounts for up to 10% of all diabetes cases. Glycemic control via the use of exogenous insulin injections in diabetic patients is incomplete, resulting in multiple long-term complications such as retinopathy, neuropathy, vasculopathy, and nephropathy. The goal of beta-cell replacement by whole-pancreas or islet transplantation is to achieve long-term insulin independence, and the proposed benefits are improved quality of life, prevention of recurrent diabetic nephropathy, stabilization or improvement in secondary complications, and improved mortality. No other regimen of insulin delivery can achieve this level of physiologic regulation.
authors.affiliation: Nephrology Division, Mount Sinai School of Medicine, New York, NY, USA.
authors.forename: Anja
authors.initials: A
authors.lastname: Richter
authors.forename: Susan M
authors.initials: SM
authors.lastname: Lerner
authors.forename: Bernd
authors.initials: B
authors.lastname: Schröppel
mesh_terms: D048909:Diabetes Complications / Q000601:surgery*; D003920:Diabetes Mellitus / Q000601:surgery*; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods*; D016381:Islets of Langerhans Transplantation; D016030:Kidney Transplantation; D016035:Pancreas Transplantation; D011788:Quality of Life; D016896:Treatment Outcome