title: Diabetes mellitus and cancer risk in a network of case-control studies.
abstract: Diabetes has been associated to the risk of a few cancer sites, though quantification of this association in various populations remains open to discussion. We analyzed the relation between diabetes and the risk of various cancers in an integrated series of case-control studies conducted in Italy and Switzerland between 1991 and 2009. The studies included 1,468 oral and pharyngeal, 505 esophageal, 230 gastric, 2,390 colorectal, 185 liver, 326 pancreatic, 852 laryngeal, 3,034 breast, 607 endometrial, 1,031 ovarian, 1,294 prostate, and 767 renal cell cancer cases and 12,060 hospital controls. The multivariate odds ratios (OR) for subjects with diabetes as compared to those without-adjusted for major identified confounding factors for the cancers considered through logistic regression models-were significantly elevated for cancers of the oral cavity/pharynx (OR = 1.58), esophagus (OR = 2.52), colorectum (OR = 1.23), liver (OR = 3.52), pancreas (OR = 3.32), postmenopausal breast (OR = 1.76), and endometrium (OR = 1.70). For cancers of the oral cavity, esophagus, colorectum, liver, and postmenopausal breast, the excess risk persisted over 10 yr since diagnosis of diabetes. Our data confirm and further quantify the association of diabetes with colorectal, liver, pancreatic, postmenopausal breast, and endometrial cancer and suggest forthe first time that diabetes may also increase the risk of oral/pharyngeal and esophageal cancer.
authors.affiliation: Department of Epidemiology, Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy. cristina.bosetti@marionegri.it
authors.forename: Cristina
authors.initials: C
authors.lastname: Bosetti
authors.forename: Valentina
authors.initials: V
authors.lastname: Rosato
authors.forename: Jerry
authors.initials: J
authors.lastname: Polesel
authors.forename: Fabio
authors.initials: F
authors.lastname: Levi
authors.forename: Renato
authors.initials: R
authors.lastname: Talamini
authors.forename: Maurizio
authors.initials: M
authors.lastname: Montella
authors.forename: Eva
authors.initials: E
authors.lastname: Negri
authors.forename: Alessandra
authors.initials: A
authors.lastname: Tavani
authors.forename: Antonella
authors.initials: A
authors.lastname: Zucchetto
authors.forename: Silvia
authors.initials: S
authors.lastname: Franceschi
authors.forename: Giovanni
authors.initials: G
authors.lastname: Corrao
authors.forename: Carlo
authors.initials: C
authors.lastname: La Vecchia
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000150:complications / Q000453:epidemiology*; D016022:Case-Control Studies; D015986:Confounding Factors, Epidemiologic; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000453:epidemiology; D004067:Digestive System Neoplasms / Q000150:complications / Q000453:epidemiology*; D016889:Endometrial Neoplasms / Q000150:complications / Q000453:epidemiology*; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000150:complications / Q000453:epidemiology; D015999:Multivariate Analysis; D010610:Pharyngeal Neoplasms / Q000150:complications / Q000453:epidemiology; D012306:Risk; D013557:Switzerland / Q000453:epidemiology