title: MicroRNA expression and activity in pediatric acute lymphoblastic leukemia (ALL).
abstract: Acute lymphoblastic leukemia (ALL) is the most common type of pediatric neoplasia. Highly heterogeneous, ALL includes several genetic subtypes with varying clinical outcome. Although, some features are well established as prognostic predictors, the details of the molecular mechanisms underlying different phenotypes are only beginning to emerge. Recently, microRNAs (miRNAs) have been shown to influence a range of physiological processes and, consequently, alterations in their expression and functions have been associated with the development of many cancers, including leukemia. This article aims to review the current state of knowledge of the role of miRNAs on the biology of childhood ALL, also including relevant findings from the adult leukemia literature.
authors.affiliation: Department of Genetics, School of Medicine of Ribeirão Preto, University of São Paulo, Ribeirão Preto, Brazil. oliveirajc@usp.br
authors.forename: Jaqueline C
authors.initials: JC
authors.lastname: de Oliveira
authors.forename: María Sol
authors.initials: MS
authors.lastname: Brassesco
authors.forename: Carlos Alberto
authors.initials: CA
authors.lastname: Scrideli
authors.forename: Luiz Gonzaga
authors.initials: LG
authors.lastname: Tone
authors.forename: Aru
authors.initials: A
authors.lastname: Narendran
mesh_terms: D000818:Animals; D002648:Child; D019008:Drug Resistance, Neoplasm; D006801:Humans; D035683:MicroRNAs / Q000378:metabolism*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000145:classification / Q000188:drug therapy / Q000378:metabolism*; D011379:Prognosis
chemical_list: D035683:MicroRNAs