title: Immunohistochemical characterization of feline mast cell tumors.
abstract: Expression of histamine, serotonin, and KIT was evaluated in 61 archived feline mast cell tumors (MCTs) from the skin (n = 29), spleen (n = 17), and gastrointestinal (GI) tract (n = 15) using immunohistochemistry. Twenty-eight percent of cutaneous MCTs, 18% of splenic MCTs, and 53% of GI MCTs displayed histamine immunoreactivity. Serotonin immunoreactivity was detected in 3 GI and 1 cutaneous MCT. Sixty-nine percent of cutaneous MCTs, 35% of splenic MCTs, and 33% of GI MCTs were positive for KIT. Expression of these biogenic amines and KIT was less common than expected. Results of this study suggest heterogeneity in feline MCTs based on anatomic location. Further studies are needed to explain the significance of these differences.
authors.affiliation: Georgia Veterinary Specialists, 455 Abernathy Road, Atlanta, GA, USA.
authors.forename: C L
authors.initials: CL
authors.lastname: Mallett
authors.forename: N C
authors.initials: NC
authors.lastname: Northrup
authors.forename: C F
authors.initials: CF
authors.lastname: Saba
authors.forename: C O
authors.initials: CO
authors.lastname: Rodriguez
authors.forename: K M
authors.initials: KM
authors.lastname: Rassnick
authors.forename: T L
authors.initials: TL
authors.lastname: Gieger
authors.forename: M O
authors.initials: MO
authors.lastname: Childress
authors.forename: E W
authors.initials: EW
authors.lastname: Howerth
mesh_terms: D000818:Animals; D002371:Cat Diseases / Q000378:metabolism / Q000473:pathology*; D002415:Cats; D041981:Gastrointestinal Tract / Q000378:metabolism / Q000473:pathology; D006632:Histamine / Q000378:metabolism*; D007150:Immunohistochemistry / Q000662:veterinary; D008407:Mast Cells / Q000378:metabolism / Q000473:pathology; D012515:Mast-Cell Sarcoma / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D008415:Mastocytosis / Q000378:metabolism / Q000473:pathology / Q000662:veterinary; D011379:Prognosis; D019009:Proto-Oncogene Proteins c-kit / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism*; D012867:Skin / Q000378:metabolism / Q000473:pathology; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D013154:Spleen / Q000378:metabolism / Q000473:pathology
chemical_list: D012701:Serotonin; D006632:Histamine; D019009:Proto-Oncogene Proteins c-kit