title: Harnessing genomics and genome biology to understand malaria biology.
abstract: Malaria is an important human disease and is the target of a global eradication campaign. New technological and informatics advancements in population genomics are being leveraged to identify genetic loci under selection in the malaria parasite and to find variants that are associated with key clinical phenotypes, such as drug resistance. This article provides a timely Review of how population-genetics-based strategies are being applied to Plasmodium falciparum both to identify genetic loci as key targets of interventions and to develop monitoring and surveillance tools that are crucial for the successful elimination and eradication of malaria.
authors.affiliation: Department of Immunology and Infectious Disease, Harvard School of Public Health, 665 Huntington Avenue, Boston, Massachusetts 02115, USA. svolkman@hsph.harvard.edu
authors.forename: Sarah K
authors.initials: SK
authors.lastname: Volkman
authors.forename: Daniel E
authors.initials: DE
authors.lastname: Neafsey
authors.forename: Stephen F
authors.initials: SF
authors.lastname: Schaffner
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Park
authors.forename: Dyann F
authors.initials: DF
authors.lastname: Wirth
mesh_terms: D000818:Animals; D000852:Anopheles / Q000469:parasitology / Q000502:physiology; D000962:Antimalarials / Q000627:therapeutic use; D004351:Drug Resistance / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D056426:Genetic Loci; D018503:Genome, Protozoan; D023281:Genomics; D006801:Humans; D008288:Malaria / Q000469:parasitology*; D008297:Male; D010963:Plasmodium falciparum / Q000187:drug effects / Q000235:genetics*; D012641:Selection, Genetic
chemical_list: D000962:Antimalarials