title: Clonidine-induced growth hormone and growth-hormone-releasing hormone release is mediated by tachykinin NK2 receptors in sheep.
abstract: Clonidine is an α(2)-adrenergic agonist, historically known to treat high blood pressure. Further studies showed that it could be used in the treatment of neuropsychiatric disorders. Afterwards, it has been reported that clonidine stimulated growth hormone (GH) release in many species including man. Using a transnasal surgery technique in awake sheep that allowed accessing hypothalamopituitary portal vessels, our laboratory previously reported that the injection of clonidine in sheep induced a significant, immediate and short-lasting increase in peripheral GH and portal GH-releasing hormone (GHRH) levels. In this study, we show that the clonidine-induced peripheral GH and portal GHRH increase in sheep appears to be mediated by the tachykinin NK2 receptor.
authors.affiliation: University of Aix-Marseille and Laboratory of Experimental Neuroendocrinology, Institut National de la Santé et de la Recherche Médicale U 297, Marseille, France.
authors.forename: Guy-Joseph
authors.initials: GJ
authors.lastname: Lemamy
authors.forename: Viviane
authors.initials: V
authors.lastname: Guillaume
authors.forename: Bénédicte
authors.initials: B
authors.lastname: Ndéboko
authors.forename: Justine
authors.initials: J
authors.lastname: Mouecoucou
authors.forename: Mireille
authors.initials: M
authors.lastname: Renard
authors.forename: Charles
authors.initials: C
authors.lastname: Oliver
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000818:Animals; D001549:Benzamides / Q000494:pharmacology; D003000:Clonidine / Q000494:pharmacology*; D013006:Growth Hormone / Q000378:metabolism*; D013007:Growth Hormone-Releasing Hormone / Q000378:metabolism*; D008297:Male; D064729:Neurokinin-1 Receptor Antagonists; D010880:Piperidines / Q000494:pharmacology; D011812:Quinuclidines / Q000494:pharmacology; D018040:Receptors, Neurokinin-1 / Q000378:metabolism; D018041:Receptors, Neurokinin-2 / Q000037:antagonists & inhibitors / Q000378:metabolism*; D012756:Sheep
chemical_list: D000316:Adrenergic alpha-Agonists; D001549:Benzamides; D064729:Neurokinin-1 Receptor Antagonists; D010880:Piperidines; D011812:Quinuclidines; D018040:Receptors, Neurokinin-1; D018041:Receptors, Neurokinin-2; C085215:SR 140333; C073839:SR 48968; D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone; D003000:Clonidine