title: Suicide ideators and attempters with schizophrenia--the role of 5-HTTLPR, rs25531, and 5-HTT VNTR Intron 2 variants.
abstract: OBJECTIVE
  To examine the role of 5-HTTLPR, rs25531 and 5-HTT VNTR Intron 2 variants in subjects with psychotic disorders manifesting suicide ideation and behaviour.
  
  
  METHODS
  The study included 519 subsequently hospitalized subjects who were genotyped for 5-HTTLPR, rs25531 and 5-HTT VNTR In2 variants. Clinical assessments included structured psychiatric interview, sociodemographic characteristics, suicide ideation and behaviour (SIBQ), severity of psychopathology (PANSS) and depression (CDSS).
  
  
  RESULTS
  Three subgroups were identified: suicide attempters (N = 161), suicide ideators (N = 174) and subjects who never reported suicide ideation or behaviour (comparative group, N = 184).
  
  
  RESULTS
  1) Suicide attempters scored highest on the CDSS, while no differences between the three clinical subgroups were detected in the PANSS scores; 2) Suicide attempters were more frequently the carriers of L(A) allele, while subjects in the comparative group were more frequently the carriers of low expression 5-HTTLPR/5-HTT rs25531 haplotype SL(G); 3) No difference was found between the three clinical groups in the 5-HTT VNTR In2 variants; 4) Subjects with 5-HTTLPR/5-HTT rs25531 intermediate expression haplotype (L(A)L(G,)SL(A)) scored higher on the PANSS general psychopathology subscale; 5) There was no association between suicide attempt or ideation and 5-HTTLPR/In2 or 5-HTTLPR/rs25531/In2 haplotype distribution.
  
  
  CONCLUSIONS
  The suicide ideators, attempters and controls did not differ significantly in 5-HTTLPR or 5-HTT VNTR In 2 variants, but 5-HTTLPR/5-HTT rs25531 haplotype might be a useful genetic marker in distinguishing these three clinical groups.
authors.affiliation: Clinical Institute of Laboratory Diagnosis, University Hospital Center Zagreb, Kispaticeva 12, 10 000 Zagreb, Croatia.
authors.forename: N
authors.initials: N
authors.lastname: Božina
authors.forename: N
authors.initials: N
authors.lastname: Jovanović
authors.forename: A
authors.initials: A
authors.lastname: Podlesek
authors.forename: M
authors.initials: M
authors.lastname: Rojnić Kuzman
authors.forename: M
authors.initials: M
authors.lastname: Kudumija Slijepčević
authors.forename: A
authors.initials: A
authors.lastname: Roguljić
authors.forename: A
authors.initials: A
authors.lastname: Dimitrović
authors.forename: T
authors.initials: T
authors.lastname: Božina
authors.forename: J
authors.initials: J
authors.lastname: Lovrić
authors.forename: H
authors.initials: H
authors.lastname: Ljubić
authors.forename: V
authors.initials: V
authors.lastname: Medved
mesh_terms: D000328:Adult; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D018598:Minisatellite Repeats / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000235:genetics*; D012565:Schizophrenic Psychology; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics*; D059020:Suicidal Ideation; D013406:Suicide, Attempted / Q000523:psychology*; D055815:Young Adult
chemical_list: C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins