title: Antiproliferative and anti-invasive effect of piceatannol, a polyphenol present in grapes and wine, against hepatoma AH109A cells.
abstract: Piceatannol is a stilbenoid, a metabolite of resveratrol found in red wine. Piceatannol and sera from rats orally given piceatannol were found to dose-dependently suppress both the proliferation and invasion of AH109A hepatoma cells in culture. Its antiproliferative effect was based on cell cycle arrest at lower concentration (25~50 μM) and on apoptosis induction at higher concentration (100 μM). Piceatannol suppressed reactive oxygen species-potentiated invasive capacity by scavenging the intracellular reactive oxygen species. These results suggest that piceatannol, unlike resveratrol, has a potential to suppress the hepatoma proliferation by inducing cell cycle arrest and apoptosis induction. They also suggest that the antioxidative property of piceatannol, like resveratrol, may be involved in its anti-invasive action. Subsequently, piceatannol was found to suppress the growth of solid tumor and metastasis in hepatoma-bearing rats. Thus, piceatannol may be a useful anticancer natural product.
authors.affiliation: Department of Applied Biological Chemistry, Graduate School of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, Tokyo, Japan.
authors.forename: Yuichiro
authors.initials: Y
authors.lastname: Kita
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Miura
authors.forename: Kazumi
authors.initials: K
authors.lastname: Yagasaki
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D059447:Cell Cycle Checkpoints / Q000187:drug effects; D048708:Cell Growth Processes / Q000187:drug effects; D045744:Cell Line, Tumor; D006861:Hydrogen Peroxide / Q000494:pharmacology; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D009361:Neoplasm Invasiveness; D009374:Neoplasms, Experimental; D010545:Peroxides / Q000032:analysis / Q000378:metabolism; D051381:Rats; D013267:Stilbenes / Q000494:pharmacology*; D027843:Vitis / Q000737:chemistry; D014920:Wine
chemical_list: D010545:Peroxides; D013267:Stilbenes; C041525:3,3',4,5'-tetrahydroxystilbene; D006861:Hydrogen Peroxide