title: Small bowel involvement is a prognostic factor in colorectal carcinomatosis treated with complete cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy.
abstract: BACKGROUND
  Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) is a promising treatment for patients with peritoneal carcinomatosis (PC). Our objective was to identify new prognostic factors in patients with PC from colorectal cancer treated with this procedure.
  
  
  METHODS
  All patients with PC from colorectal cancer treated by HIPEC from January 2000 to December 2007 were prospectively included. The tumor extension was assessed by the Peritoneal Cancer Index (PCI) and the residual disease was recorded using the completeness cytoreductive score (CCs). All clinical and treatment data were computed in univariate and multivariable analyses using survival as primary end point.
  
  
  RESULTS
  We carried out 51 complete procedures in 49 consecutive patients. The mean PCI was 10. The allocation of CCs was: CC-0 = 37, CC-1 = 14. The five-year overall and progression-free survival rate were 40% and 20%, respectively. Several prognostic factors for survival were identified by univariate analysis: PCI < 9 (P < 0.001), CC-0 vs. CC-1 (P < 0.01) and involvement of area 4 (P = 0.06), area 5 (P = 0.031), area 7 (P = 0.014), area 8 (P = 0.022), area 10 (P < 0.0001), and area 11 (P = 0.02). Only the involvement of the distal jejunum (area 10) was significant in the multivariable analysis (P = 0.027).
  
  
  CONCLUSIONS
  We demonstrated that the involvement of area 10 (distal jejunum of the PCI score) was an independent factor associated with poor prognosis.
authors.affiliation: Department of General Surgery and Digestive Cancerology, Centre Hospitalier Universitaire de Nice, Nice Cedex 3 B, France. benizri.e@chu-nice.fr
authors.forename: Emmanuel I
authors.initials: EI
authors.lastname: Benizri
authors.forename: Jean-Louis
authors.initials: JL
authors.lastname: Bernard
authors.forename: Amine
authors.initials: A
authors.lastname: Rahili
authors.forename: Daniel
authors.initials: D
authors.lastname: Benchimol
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Bereder
mesh_terms: D016009:Chi-Square Distribution; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D016001:Confidence Intervals; D018450:Disease Progression; D005260:Female; D005334:Fever; D006801:Humans; D007078:Ileal Neoplasms / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D007263:Infusions, Parenteral; D007421:Intestine, Small / Q000473:pathology* / Q000601:surgery; D007580:Jejunal Neoplasms / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D013223:Statistics as Topic; D016019:Survival Analysis