title: Trichinella spiralis: infection changes serum paraoxonase-1 levels, lipid profile, and oxidative status in rats.
abstract: Paraoxonase-1 (PON1) is an HDL-associated enzyme with anti-atherogenic properties. Reduced PON1 activity has previously been observed in Nippostrongylus brasiliensis-infected rats. However, the effect of chronic zoonotic nematode infections on serum PON1 activity has not yet been studied. Therefore, we evaluated the effect of Trichinella spiralis infection on serum PON1 activity, the lipid profile, and oxidative stress in rats. There were significant reductions in serum PON1 activities (Day 2-Week 7 post-infection) in rats infected with T. spiralis, and these reductions were associated with significant increases in the serum levels of triglyceride and LDL/VLDL, as well as a significant reduction in the level of HDL. Moreover, T. spiralis infection was associated with a status of oxidative stress indicated by increased concentrations of superoxide dismutase and malondialdehyde. Given the zoonotic prevalence of T. spiralis and the cardioprotective role of PON1, further mechanistic research in this area is warranted.
authors.affiliation: Laboratory of Veterinary Parasitic Diseases, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan.
authors.forename: Shogo
authors.initials: S
authors.lastname: Mido
authors.forename: Eman Mohamed
authors.initials: EM
authors.lastname: Fath
authors.forename: Ayman Samir
authors.initials: AS
authors.lastname: Farid
authors.forename: Nariaki
authors.initials: N
authors.lastname: Nonaka
authors.forename: Yuzaburo
authors.initials: Y
authors.lastname: Oku
authors.forename: Yoichiro
authors.initials: Y
authors.lastname: Horii
mesh_terms: D000818:Animals; D043303:Aryldialkylphosphatase / Q000097:blood*; D002784:Cholesterol / Q000097:blood; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood; D008297:Male; D051379:Mice; D018384:Oxidative Stress; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000097:blood; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis; D017160:Trichinella spiralis / Q000502:physiology*; D014235:Trichinellosis / Q000097:blood / Q000201:enzymology / Q000378:metabolism*; D014280:Triglycerides / Q000097:blood
chemical_list: D008055:Lipids; D008074:Lipoproteins; D017392:Thiobarbituric Acid Reactive Substances; D014280:Triglycerides; D002784:Cholesterol; D013482:Superoxide Dismutase; D043303:Aryldialkylphosphatase