title: [The epidemiological impact of varicella vaccination in kindergartens, primary and secondary schools in Beijing].
abstract: OBJECTIVE
  To study the epidemiological impact of varicella vaccine vaccination on kindergartens and school children in Beijing.
  
  
  METHODS
  According to "China Information System for Diseases Control and Prevention", the reported clinical diagnosis varicella cases were tracked in kindergartens, primary and secondary schools whose onset date were from 2008 to 2010. Epidemiological survey was conducted and epidemiological features were analyzed.
  
  
  RESULTS
  A total of 21 474 varicella cases were investigated: 55.3% (11 883 cases) had been vaccinated by varicella vaccine. Of cases with definite immunization history, interval between vaccination date and onset date were from 30 days to 1 year accounted for 3.4% (286/8510), 1 to 3 years accounted for 18.2% (1551/8510), 3 to 5 years accounted for 28.6% (2431/8510), 5 to 10 years accounted for 34.3% (2916/8510) (left-closed right-open interval); The peak age of onset was 4 years old in cases without immunization history, which was 6 years old in cases with immunization history; The proportion of cases with immunization history (≥ 30 days) had increased from 42.4% (2862/6754) in 2008 to 56.3% (4327/7679) in 2010. The cases with no fever had a higher proportion (54.9%, 6413/11 679) of immunization history (≥ 30 days) than cases with fever (47.7%, 4533/9500) (P < 0.01); The cases with rashes less than 50 had a higher proportion (57.4%, 8045/14 020) of immunization history (≥ 30 days) than cases with rashes more than 50 (40.2%, 2902/7216) (P < 0.01).
  
  
  CONCLUSIONS
  Varicella vaccine delays the peak age of onset, alleviates the symptoms. The current immunization strategy can not block varicella spread in kindergartens, primary and secondary schools.
authors.affiliation: Beijing Center for Disease Prevention and Control, China.
authors.forename: Luo-dan
authors.initials: LD
authors.lastname: Suo
authors.forename: Li
authors.initials: L
authors.lastname: Lu
authors.forename: Jiang
authors.initials: J
authors.lastname: Wu
authors.forename: Dong-lei
authors.initials: DL
authors.lastname: Liu
authors.forename: Xing-huo
authors.initials: XH
authors.lastname: Pang
mesh_terms: D000293:Adolescent; D002644:Chickenpox / Q000453:epidemiology* / Q000517:prevention & control*; D019433:Chickenpox Vaccine; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D012574:Schools; D012578:Schools, Nursery
chemical_list: D019433:Chickenpox Vaccine