title: [Pax-2 antigen expression in kidney tumours].
abstract: Pax-2 transcriptional factor is expressed during kidney development and could re-express in renal tumors. The aim of this study was to examine Pax-2 expression in different types of renal cell carcinoma (RCC) in order to see whether it is good immunohistochemical marker.
  
  
  METHODS
  We analyzed 48 different renal tumours stained with Pax-2 antibody. Pax-2 positive reaction was noticed in nucleus or cytoplasm. Expression of this antigen in tumours tissue was correlated with tumour stage and nuc-lear grade. Pax-2 expression between different histological RCC types was analyzed by chi2 test and Fishers test for two in-depended samples.
  
  
  RESULTS
  Pax-2 is expressed by a high percentage of re-nal tumors regardless of histologic type. Significant diffe-rence of Pax-2 expression between oncocytomas and chromofobe RCC was found.
  
  
  CONCLUSIONS
  Nuclear expression of Pax-2 is useful diagnostic kidney tumour marker. Pax-2 showed stronger expression in lower malignancy kidney tumours and in oncocytomas, than in high grade RCC like in those with sarcomatoid differentiation
authors.affiliation: Institut za patologiju, Beograd.
authors.forename: Jelena M
authors.initials: JM
authors.lastname: Vjestica
authors.forename: Jasmina
authors.initials: J
authors.lastname: Marković-Lipkovski
authors.forename: Cane D
authors.initials: CD
authors.lastname: Tulić
authors.forename: Milan R
authors.initials: MR
authors.lastname: Djokić
authors.forename: Bojan S
authors.initials: BS
authors.lastname: Segar
authors.forename: Sanja L
authors.initials: SL
authors.lastname: Cirović
authors.forename: Martina M
authors.initials: MM
authors.lastname: Stojanović
authors.forename: Aleksandar M
authors.initials: AM
authors.lastname: Vuksanović
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D002292:Carcinoma, Renal Cell / Q000175:diagnosis / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000378:metabolism*; D051762:PAX2 Transcription Factor / Q000378:metabolism*
chemical_list: D014408:Biomarkers, Tumor; D051762:PAX2 Transcription Factor