title: [Intraductal papillary mucinous neoplasm of the pancreas: case report and review of the literature].
abstract: Intraductal papillary mucinous neoplasm (IPMN) of the pancreas is a relatively rare clinical entity with a main characteristic being mucus production. Extension of IPMN along pancretic ducts and mucus production lead to ductal obstruction and dilatation, resulting in recurrent episodes of acute pancreatitis. Molecular background of IPMN-a comprises several aberrations, with the K-ras gene mutation being the likely trigger that initiates further genetic changes. Due to its indolent nature, IPMN is most commonly diagnosed in the 7th decade of life. Depending on the histology type, IPMN has a malignant potential. Therefore, surgical therapy remains a "gold standard" of treatment. Insidious, slow progression of the disease and absence of symptoms in a certain number of patients makes diagnostic approach to this entity difficult. In this paper we present a patient with IPMN of the pancreas, in whom the episodes of acute pancreatitis had been present for 22 years.
authors.affiliation: Zavod za gastroenterologiju i hepatologiju, Klinika za unutrainje bolesti Medicinskog fakulteta Sveucilista u Zagrebu, KBC Zagreb.
authors.forename: Hrvoje
authors.initials: H
authors.lastname: Iveković
authors.forename: Nadan
authors.initials: N
authors.lastname: Rustemović
authors.forename: Milorad
authors.initials: M
authors.lastname: Opacić
authors.forename: Ognjan
authors.initials: O
authors.lastname: Deban
authors.forename: Bosko
authors.initials: B
authors.lastname: Romic
authors.forename: Jasminka Jakić
authors.initials: JJ
authors.lastname: Razumović
authors.forename: Rajko
authors.initials: R
authors.lastname: Ostojić
authors.forename: Roland
authors.initials: R
authors.lastname: Pulanić
authors.forename: Boris
authors.initials: B
authors.lastname: Vucelić
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000175:diagnosis / Q000473:pathology*; D021441:Carcinoma, Pancreatic Ductal / Q000175:diagnosis / Q000473:pathology*; D002291:Carcinoma, Papillary / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000473:pathology*