title: The distinctive nature of atherosclerotic vascular disease in diabetes: pathophysiological and morphological insights.
abstract: As the incidence of diabetes mellitus continues to rise, parallel increases in the rates of diabetic atherosclerotic vascular disease are projected to impart major health and socioeconomic challenges for authorities worldwide. Diabetes results in a proatherogenic phenotype, manifesting in an accelerated, diffuse, polyvascular fashion. In this review, we highlight the pathophysiological and morphological hallmarks of diabetic atherosclerosis.
authors.affiliation: Department of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, OH 44195, USA.
authors.forename: Rishi
authors.initials: R
authors.lastname: Puri
authors.forename: Yu
authors.initials: Y
authors.lastname: Kataoka
authors.forename: Kiyoko
authors.initials: K
authors.lastname: Uno
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Nicholls
mesh_terms: D050197:Atherosclerosis / Q000097:blood / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology*; D002114:Calcinosis / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D003925:Diabetic Angiopathies / Q000097:blood / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000473:pathology* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D018384:Oxidative Stress; D017382:Reactive Oxygen Species
chemical_list: D017382:Reactive Oxygen Species