title: Association between schizophrenia and common variation in neurocan (NCAN), a genetic risk factor for bipolar disorder.
abstract: A recent study found genome-wide significant association between common variation in the gene neurocan (NCAN, rs1064395) and bipolar disorder (BD). In view of accumulating evidence that BD and schizophrenia partly share genetic risk factors, we tested this single-nucleotide polymorphism for association with schizophrenia in three independent patient-control samples of European ancestry, totaling 5061 patients and 9655 controls. The rs1064395 A-allele, which confers risk for BD, was significantly over-represented in schizophrenia patients compared to controls (p=2.28×10(-3); odds ratio=1.11). Follow-up in non-overlapping samples from the Schizophrenia Psychiatric GWAS Consortium (5537 patients, 8043 controls) provided further support for our finding (p=0.0239, odds ratio=1.07). Our data suggest that genetic variation in NCAN is a common risk factor for BD and schizophrenia.
authors.affiliation: Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany.
authors.forename: Thomas W
authors.initials: TW
authors.lastname: Mühleisen
authors.forename: Manuel
authors.initials: M
authors.lastname: Mattheisen
authors.forename: Jana
authors.initials: J
authors.lastname: Strohmaier
authors.forename: Franziska
authors.initials: F
authors.lastname: Degenhardt
authors.forename: Lutz
authors.initials: L
authors.lastname: Priebe
authors.forename: C Christoph
authors.initials: CC
authors.lastname: Schultz
authors.forename: René
authors.initials: R
authors.lastname: Breuer
authors.forename: Sandra
authors.initials: S
authors.lastname: Meier
authors.forename: Per
authors.initials: P
authors.lastname: Hoffmann
authors.forename: Fernando
authors.initials: F
authors.lastname: Rivandeneira
authors.forename: Albert
authors.initials: A
authors.lastname: Hofman
authors.forename: André G
authors.initials: AG
authors.lastname: Uitterlinden
authors.forename: Susanne
authors.initials: S
authors.lastname: Moebus
authors.forename: Christian
authors.initials: C
authors.lastname: Gieger
authors.forename: Rebecca
authors.initials: R
authors.lastname: Emeny
authors.forename: Karl-Heinz
authors.initials: KH
authors.lastname: Ladwig
authors.forename: H-Erich
authors.initials: HE
authors.lastname: Wichmann
authors.forename: Markus
authors.initials: M
authors.lastname: Schwarz
authors.forename: Jutta
authors.initials: J
authors.lastname: Kammerer-Ciernioch
authors.forename: Ralf G M
authors.initials: RG
authors.lastname: Schlösser
authors.forename: Igor
authors.initials: I
authors.lastname: Nenadic
authors.forename: Heinrich
authors.initials: H
authors.lastname: Sauer
authors.forename: Rainald
authors.initials: R
authors.lastname: Mössner
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Maier
authors.forename: Dan
authors.initials: D
authors.lastname: Rujescu
authors.forename: Christoph
authors.initials: C
authors.lastname: Lange
authors.forename: Roel A
authors.initials: RA
authors.lastname: Ophoff
authors.forename: Thomas G
authors.initials: TG
authors.lastname: Schulze
authors.forename: Marcella
authors.initials: M
authors.lastname: Rietschel
authors.forename: Markus M
authors.initials: MM
authors.lastname: Nöthen
authors.forename: Sven
authors.initials: S
authors.lastname: Cichon
mesh_terms: D001714:Bipolar Disorder / Q000235:genetics; D016022:Case-Control Studies; D011508:Chondroitin Sulfate Proteoglycans / Q000235:genetics*; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D037181:Lectins, C-Type / Q000235:genetics*; D009419:Nerve Tissue Proteins / Q000235:genetics*; D058580:Neurocan; D020641:Polymorphism, Single Nucleotide; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D011508:Chondroitin Sulfate Proteoglycans; D037181:Lectins, C-Type; D009419:Nerve Tissue Proteins; D058580:Neurocan; C076817:NCAN protein, human