title: Another side of the oxazaphospholidine oxide chiral ortho-directing group.
abstract: A new ferrocenyl oxazaphospholidine oxide 3 was synthesized together with its P-epimer 2 in the reaction of ferrocene lithium with phosphoramidite chloride 1. 3 was successfully derivatized into planar chiral 1,2-ferrocenes, including phosphine ligands, via highly diastereoselective ortho-lithiation and subsequent functionalization; these compounds display opposite planar chirality to those obtained from 2. Some of these 1,2-ferrocenes were further lithiated, allowing for the introduction of a free phosphine group at the oxazaphospholidine ring. The X-ray structures of the compounds 2 and 3 as well as those of the new 1,2-ferrocenes 4 and 7 have been determined.
authors.affiliation: Department of Chemistry, University of Liverpool, Liverpool L69 7ZD, UK.
authors.forename: Nelson
authors.initials: N
authors.lastname: Martins
authors.forename: Nuno
authors.initials: N
authors.lastname: Mateus
authors.forename: Daniele
authors.initials: D
authors.lastname: Vinci
authors.forename: Ourida
authors.initials: O
authors.lastname: Saidi
authors.forename: Amadeu
authors.initials: A
authors.lastname: Brigas
authors.forename: John
authors.initials: J
authors.lastname: Bacsa
authors.forename: Jianliang
authors.initials: J
authors.lastname: Xiao