title: The R-DoC initiative: science and practice.
abstract: A research focus upon dimensions of observable behaviors and neurobiological indices, as outlined in the R-DoC initiative, is likely to enhance our understanding of psychopathology in a number of ways that are outlined in this article. Specific examples include a greater understanding of the mechanisms underlying comorbidity and complexity of symptom manifestation, individual differences in symptom expression, and developmental changes in symptom expression. Furthermore, the R-DoC approach may have treatment implications, including treatment efficacy, and identification of treatment moderators and treatment mediators.
authors.affiliation: Department of Psychology, University of California, Los Angeles, CA 90095, USA. craske@psych.ucla.edu
authors.forename: Michelle G
authors.initials: MG
authors.lastname: Craske
mesh_terms: D006801:Humans; D001523:Mental Disorders / Q000145:classification / Q000503:physiopathology / Q000523:psychology; D017410:Practice Guidelines as Topic / Q000592:standards; D011599:Psychopathology / Q000379:methods / Q000592:standards / Q000639:trends