title: Effect of non-random mating on genomic and BLUP selection schemes.
abstract: BACKGROUND
  The risk of long-term unequal contribution of mating pairs to the gene pool is that deleterious recessive genes can be expressed. Such consequences could be alleviated by appropriately designing and optimizing breeding schemes i.e. by improving selection and mating procedures.
  
  
  METHODS
  We studied the effect of mating designs, random, minimum coancestry and minimum covariance of ancestral contributions on rate of inbreeding and genetic gain for schemes with different information sources, i.e. sib test or own performance records, different genetic evaluation methods, i.e. BLUP or genomic selection, and different family structures, i.e. factorial or pair-wise.
  
  
  RESULTS
  Results showed that substantial differences in rates of inbreeding due to mating design were present under schemes with a pair-wise family structure, for which minimum coancestry turned out to be more effective to generate lower rates of inbreeding. Specifically, substantial reductions in rates of inbreeding were observed in schemes using sib test records and BLUP evaluation. However, with a factorial family structure, differences in rates of inbreeding due mating designs were minor. Moreover, non-random mating had only a small effect in breeding schemes that used genomic evaluation, regardless of the information source.
  
  
  CONCLUSIONS
  It was concluded that minimum coancestry remains an efficient mating design when BLUP is used for genetic evaluation or when the size of the population is small, whereas the effect of non-random mating is smaller in schemes using genomic evaluation.
authors.affiliation: Department of Animal and Aquacultural Sciences, Norwegian University of Life Science, Ås, Norway. kahsay.nirea@umb.no
authors.forename: Kahsay G
authors.initials: KG
authors.lastname: Nirea
authors.forename: Anna K
authors.initials: AK
authors.lastname: Sonesson
authors.forename: John A
authors.initials: JA
authors.lastname: Woolliams
authors.forename: Theo H E
authors.initials: TH
authors.lastname: Meuwissen
mesh_terms: D000465:Algorithms; D000822:Animal Husbandry; D000818:Animals; D017756:Aquaculture; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D016678:Genome; D007178:Inbreeding; D008297:Male; D008957:Models, Genetic; D010375:Pedigree
chemical_list: D005819:Genetic Markers