title: Markers of vulnerability to obsessive-compulsive disorder in an ultra-high risk sample of patients who developed psychosis.
abstract: OBJECTIVE
  The study aims to identify markers of vulnerability to obsessive-compulsive disorder (OCD) in an ultra-high risk sample of patients who developed psychosis.
  
  
  METHODS
  Three hundred and eleven patients at ultra-high risk for psychosis were examined at baseline and after a mean of 7.4 years follow-up. Patients who developed psychosis with OCD (PSY + OCD; n = 13) and psychosis without OCD (PSY - OCD; n = 45) were compared in terms of socio-demographic and clinical features.
  
  
  RESULTS
  PSY + OCD patients displayed greater severity of depression before and after conversion to PSY + OCD, and increased rates of depressive disorders before exhibiting PSY + OCD. However, they only displayed greater severity of anxiety and increased rates of non-OCD anxiety disorders after psychosis. Further, PSY + OCD patients were more likely to report a positive family history for anxiety disorders than PSY - OCD.
  
  
  CONCLUSIONS
  Although depression and a family history of anxiety disorder may act as vulnerability markers for OCD in psychosis, the resulting anxiety may be a correlate or a consequence of PSY + OCD.
authors.affiliation: Melbourne Neuropsychiatry Centre, University of Melbourne and Melbourne Health, Carlton South, Australia. lfontenelle@gmail.com
authors.forename: Leonardo F
authors.initials: LF
authors.lastname: Fontenelle
authors.forename: Ashleigh
authors.initials: A
authors.lastname: Lin
authors.forename: Christos
authors.initials: C
authors.lastname: Pantelis
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Wood
authors.forename: Barnaby
authors.initials: B
authors.lastname: Nelson
authors.forename: Alison R
authors.initials: AR
authors.lastname: Yung
mesh_terms: D000293:Adolescent; D000328:Adult; D001008:Anxiety Disorders / Q000150:complications / Q000523:psychology; D001315:Australia; D003866:Depressive Disorder / Q000150:complications / Q000523:psychology; D005192:Family Health / Q000706:statistics & numerical data; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000150:complications / Q000523:psychology*; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D011618:Psychotic Disorders / Q000150:complications / Q000523:psychology*; D012307:Risk Factors