title: Can we cure HIV-1-associated nephropathy in transgenic mice?
abstract: HIV-1-associated nephropathy (HIVAN) is a rapidly progressive form of focal segmental glomerulosclerosis. HIV transgenic mice can develop a HIVAN-like renal disease. Zhong et al. show that the oral administration of a cyclic nucleotide phosphodiesterase 4 inhibitor and a retinoic acid receptor-α agonist can prevent the development of HIVAN in transgenic mice, acting through a cAMP-dependent mechanism that is independent of HIV-1 genes. These findings suggest that endogenous host factors play a critical role in HIVAN.
authors.affiliation: Center for Molecular Physiology Research, The George Washington University, Washington, DC, USA. Pray@cnmc.org
authors.forename: Patricio E
authors.initials: PE
authors.lastname: Ray
mesh_terms: D016263:AIDS-Associated Nephropathy / Q000517:prevention & control*; D000631:Aminopyridines / Q000494:pharmacology*; D000818:Animals; D001549:Benzamides / Q000494:pharmacology*; D001565:Benzoates / Q000494:pharmacology*; D003521:Cyclopropanes / Q000494:pharmacology; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D015497:HIV-1 / Q000235:genetics*; D007684:Kidney Tubules / Q000187:drug effects*; D008297:Male; D058988:Phosphodiesterase 4 Inhibitors / Q000494:pharmacology*; D051437:Renal Insufficiency / Q000517:prevention & control*; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*
chemical_list: D000631:Aminopyridines; D001549:Benzamides; D001565:Benzoates; D003521:Cyclopropanes; D058988:Phosphodiesterase 4 Inhibitors; D013764:Tetrahydronaphthalenes; C424423:Roflumilast; C068073:Am 580