title: Staphylococcus aureus infections in pediatric patients with diabetes mellitus.
abstract: OBJECTIVE
  To describe Staphylococcus aureus infections in children with diabetes mellitus (DM).
  
  
  METHODS
  Children with DM (cases) and S. aureus infections (2/02-6/10) were identified from a surveillance database. Patient charts were reviewed, and S. aureus isolates were characterized by molecular methods. Cases were compared to age-matched controls without DM but with CA-S. aureus skin and soft tissue infections (SSTI) using conditional logistic regression.
  
  
  RESULTS
  Forty-seven cases were identified; 41 were matched with 123 controls. Four cases had osteomyelitis and 43 had SSTI. Mean age was 14.2 years and 63% of cases had hemoglobin (Hb) A1c levels above 10%. Cases and controls differed by gender (85% vs. 45% female, P < 0.001), BMI% (median 87% vs. 72%, P = 0.04), methicillin-resistant S. aureus (MRSA) infection (49% vs. 68%, P = 0.04), and recurrent infections (22% vs. 4%, P = 0.001). Among cases, 88% of recurrences were caused by MRSA.
  
  
  CONCLUSIONS
  The majority of cases had poor glycemic control, more recurrences, fewer primary MRSA infections and were more likely to be female compared to a control group. Improved glycemic control may reduce the risk for infection, and decrease hospitalizations due to S. aureus infections.
authors.affiliation: Department of Pediatrics, Baylor College of Medicine and Texas Children's Hospital, Houston, TX, USA.
authors.forename: Erin N
authors.initials: EN
authors.lastname: Menne
authors.forename: Rona Yoffe
authors.initials: RY
authors.lastname: Sonabend
authors.forename: Edward O
authors.initials: EO
authors.lastname: Mason
authors.forename: Linda B
authors.initials: LB
authors.lastname: Lamberth
authors.forename: Wendy A
authors.initials: WA
authors.lastname: Hammerman
authors.forename: Charles G
authors.initials: CG
authors.lastname: Minard
authors.forename: Sheldon L
authors.initials: SL
authors.lastname: Kaplan
authors.forename: Kristina G
authors.initials: KG
authors.lastname: Hulten
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D048909:Diabetes Complications / Q000453:epidemiology*; D005260:Female; D038321:Glycemic Index; D006801:Humans; D008297:Male; D012307:Risk Factors; D013203:Staphylococcal Infections / Q000453:epidemiology*; D013211:Staphylococcus aureus / Q000302:isolation & purification*