title: Thomas K. Jeffers: pioneer of coccidiosis research.
abstract: Thomas K. Jeffers has made many significant contributions to our understanding of the biology of the parasite Eimeria, the cause of coccidiosis in poultry. His work has had direct practical application for the control of this widespread disease. Topics discussed include Jeffers' pioneering work concerned with genetics of the host response to infection, the nature of biological and immunological intraspecific variation, drug resistance and discovery, field surveys of resistance, and his most recognized achievement-the demonstration that the lifecycle of coccidia may be altered by artificial selection. Parasites so modified are attenuated but retain their immunogenicity, a discovery that has led to the development of live vaccines that are inherently non-pathogenic. This article provides a brief biography and describes the contributions that Jeffers has made to our knowledge of coccidiosis.
authors.affiliation: Department of Poultry Science, University of Arkansas, Fayetteville, AR 72701, USA. dchapman@uark.edu
authors.forename: H D
authors.initials: HD
authors.lastname: Chapman
mesh_terms: D000818:Animals; D001715:Bird Diseases / Q000235:genetics / Q000473:pathology* / Q000517:prevention & control*; D001717:Birds; D003048:Coccidiosis / Q000473:pathology / Q000517:prevention & control / Q000662:veterinary*; D004539:Eimeria / Q000276:immunology* / Q000502:physiology*; D049673:History, 20th Century; D049674:History, 21st Century; D016052:Protozoan Vaccines / Q000276:immunology / Q000627:therapeutic use*; D012106:Research / Q000266:history*
chemical_list: D016052:Protozoan Vaccines