title: Comparison of the use of cabergoline and gonadotrophin to treat primary and secondary anoestrus in bitches.
abstract: OBJECTIVE
  To determine the efficacy and reliability of cabergoline and pregnant mare's serum gonadotrophin (PMSG) for induction of oestrus in bitches with primary or secondary anoestrus.
  
  
  METHODS
  We studied 39 healthy bitches of various breeds aged 2-6 years and in primary or secondary anoestrus: 20 bitches were administered 5 µg/kg/day cabergoline orally until day 2 after the onset of pro-oestrus or for a maximum of 42 days, and 19 bitches were administered 20 IU/kg/day PMSG intramuscularly for 5 consecutive days, followed by an additional single injection of 25 IU/kg of human chorionic gonadotrophin on the fifth day.
  
  
  RESULTS
  The rates of oestrus induction in the primary and secondary anoestrous bitches treated with cabergoline and PMSG were found to be similar. Pregnancy and whelping rates in the cabergoline group were statistically different from the rates in the PMSG group (P < 0.001).
  
  
  CONCLUSIONS
  Cabergoline is more effective and reliable for the induction of a fertile oestrus in bitches with primary or secondary anoestrous.
authors.affiliation: Department of Obstetrics and Gynaecology, Faculty of Veterinary Medicine, University of Uludag, Dogum ve Jinekoloji Ana Bilim Dali, Bursa, Turkey. deniznak@gmail.com
authors.forename: D
authors.initials: D
authors.lastname: Nak
authors.forename: Y
authors.initials: Y
authors.lastname: Nak
authors.forename: G
authors.initials: G
authors.lastname: Simsek
mesh_terms: D000284:Administration, Oral; D000780:Anestrus / Q000187:drug effects*; D000818:Animals; D001947:Breeding; D000077465:Cabergoline; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004873:Ergolines / Q000008:administration & dosage / Q000627:therapeutic use*; D004971:Estrus / Q000187:drug effects / Q000502:physiology; D005260:Female; D006062:Gonadotropins / Q000008:administration & dosage / Q000627:therapeutic use*; D007273:Injections, Intramuscular / Q000662:veterinary; D010062:Ovulation Induction / Q000379:methods / Q000662:veterinary*; D011247:Pregnancy; D018873:Pregnancy Rate
chemical_list: D004873:Ergolines; D006062:Gonadotropins; D000077465:Cabergoline