title: Regional effects of magnetization dispersion on quantitative perfusion imaging for pulsed and continuous arterial spin labeling.
abstract: Most experiments assume a global transit delay time with blood flowing from the tagging region to the imaging slice in plug flow without any dispersion of the magnetization. However, because of cardiac pulsation, nonuniform cross-sectional flow profile, and complex vessel networks, the transit delay time is not a single value but follows a distribution. In this study, we explored the regional effects of magnetization dispersion on quantitative perfusion imaging for varying transit times within a very large interval from the direct comparison of pulsed, pseudo-continuous, and dual-coil continuous arterial spin labeling encoding schemes. Longer distances between tagging and imaging region typically used for continuous tagging schemes enhance the regional bias on the quantitative cerebral blood flow measurement causing an underestimation up to 37% when plug flow is assumed as in the standard model.
authors.affiliation: Max-Planck Institute for Biological Cybernetics, High Field Magnetic Resonance Center, Tübingen, Germany. mustafa.cavusoglu@tuebingen.mpg.de
authors.forename: Mustafa
authors.initials: M
authors.lastname: Çavuşoğlu
authors.forename: Rolf
authors.initials: R
authors.lastname: Pohmann
authors.forename: Harold Christopher
authors.initials: HC
authors.lastname: Burger
authors.forename: Kâmil
authors.initials: K
authors.lastname: Uludağ
mesh_terms: D000328:Adult; D000465:Algorithms; D016477:Artifacts; D001783:Blood Flow Velocity / Q000502:physiology; D001921:Brain / Q000033:anatomy & histology / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D060526:Magnetic Fields; D018810:Magnetic Resonance Angiography / Q000379:methods*; D008297:Male; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013113:Spin Labels
chemical_list: D013113:Spin Labels