title: Low serum MMP-1 in breast cancer: a negative prognostic factor?
abstract: In this study we investigated the prognostic significance of serum matrix metalloproteinase (MMP)-1 levels in early-stage breast cancer patients and correlated these levels with various clinicopathologic parameters. MMP-1 levels were determined by enzyme-linked immunosorbent assay. MMP-1 serum levels in patients (n = 60) were significantly lower than in healthy subjects (n = 20, p < 0.0001). We found significant negative correlation between serum levels of MMP-1 and several negative prognostic factors of breast cancer. Kaplan-Meier analysis showed significantly shorter 5-year survival in patients with lower values of MMP-1 compared to those with high levels of MMP-1 (p = 0.0147). Our results suggest a negative prognostic role of low serum MMP-1.
authors.affiliation: Department of Pathophysiology, University Hospital Center Zagreb and Zagreb Medical School, Zagreb, Croatia. ana.kulic1@zg.t-com.hr
authors.forename: A
authors.initials: A
authors.lastname: Kulić
authors.forename: N
authors.initials: N
authors.lastname: Dedić Plavetić
authors.forename: J
authors.initials: J
authors.lastname: Vrbanec
authors.forename: M
authors.initials: M
authors.lastname: Sirotković-Skerlev
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D001943:Breast Neoplasms / Q000201:enzymology* / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D020781:Matrix Metalloproteinase 1 / Q000097:blood*; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012372:ROC Curve; D013997:Time Factors
chemical_list: D014408:Biomarkers, Tumor; D020781:Matrix Metalloproteinase 1