title: Cerebral blood flow in the subgenual anterior cingulate cortex and modulation of the mood-regulatory networks in a successful rTMS treatment for major depressive disorder.
abstract: The subgenual anterior cingulate cortex (Cg25) has been reported to be a node of mood-regulatory networks. Using a responder and a non-responder of repetitive transcranial magnetic stimulation (rTMS) for depression, we examined pre/post-treatment cerebral blood flow (CBF) in the Cg25 and treatment-related CBF changes in cortical/subcortical regions. In the responder, pre-treatment Cg25 perfusion was higher and was decreased after treatment, in addition, CBF was increased in the frontal and parietal regions and decreased in the hippocampus and basal ganglia. Our results suggest that rTMS treatment response may be related to pre-treatment Cg25 activity and modulation of the Cg25 and mood-regulatory networks.
authors.affiliation: Department of Neuropsychiatry, Wakayama Medical University, Wakayama, Japan. t-shun@wakayama-med.ac.jp
authors.forename: Shun
authors.initials: S
authors.lastname: Takahashi
authors.forename: Satoshi
authors.initials: S
authors.lastname: Ukai
authors.forename: Tomikimi
authors.initials: T
authors.lastname: Tsuji
authors.forename: Asami
authors.initials: A
authors.lastname: Kose
authors.forename: Masaru
authors.initials: M
authors.lastname: Shoyama
authors.forename: Masahiro
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Masatoshi
authors.initials: M
authors.lastname: Okumura
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Shinosaki
mesh_terms: D002560:Cerebrovascular Circulation / Q000502:physiology*; D003865:Major Depressive Disorder / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy*; D005260:Female; D007839:Functional Laterality; D006179:Gyrus Cinguli / Q000098:blood supply* / Q000000981:diagnostic imaging; D006801:Humans; D021621:Imaging, Three-Dimensional; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D013997:Time Factors; D015899:Tomography, Emission-Computed, Single-Photon; D050781:Transcranial Magnetic Stimulation / Q000379:methods; D016896:Treatment Outcome