title: Microscopic and nuclear morphometric findings of chromophobe renal cell carcinoma, renal oncocytoma, and tumor with overlapping histology.
abstract: We compared the microscopic and nuclear morphometric characteristics of classical chromophobe renal cell carcinoma (C-ChRC) and renal oncocytoma (RO) and applied meaningful characteristics to differentiate eosinophilic chromophobe renal cell carcinoma (E-ChRC) from RO that has overlapping histology (RO-OH) with E-ChRC to know the usefulness of nuclear morphometry. Microscopic and morphometric characteristics were evaluated in 24 C-ChRCs, 6 E-ChRCs, 5 RO-OHs, and 25 classical ROs (C-ROs). The microscopic findings favoring C-ChRC were rasinoid nuclei, perinuclear halo, and distinct cytoplasmic membrane. Characteristic for C-RO was either stromal edema or hyalinization. The morphometric values of nearest nuclear distance, shortest nuclear diameter, and nuclear diameter ratio were significantly different between C-ChRC and C-RO. However, it was impossible to distinguish E-ChRC from RO-OH by histology and nuclear morphometry. The results of our study show that nuclear morphometry and histomorphology can distinguish between C-ChRC and C-RO but not between E-ChRC and RO-OH.
authors.affiliation: Department of Pathology, Chonnam National University Hwasun Hospital, Chonnam/Chonnam National University Medical School, Gwangju, 501-749, Republic of Korea.
authors.forename: Sung Sun
authors.initials: SS
authors.lastname: Kim
authors.forename: Yoo Duk
authors.initials: YD
authors.lastname: Choi
authors.forename: Min Keun
authors.initials: MK
authors.lastname: Shim
authors.forename: Jin
authors.initials: J
authors.lastname: Kim
authors.forename: Yong Mee
authors.initials: YM
authors.lastname: Cho
authors.forename: Ja June
authors.initials: JJ
authors.lastname: Jang
authors.forename: Ryung Jin
authors.initials: RJ
authors.lastname: Park
authors.forename: Sang Woo
authors.initials: SW
authors.lastname: Juhng
authors.forename: Chan
authors.initials: C
authors.lastname: Choi
mesh_terms: D018249:Adenoma, Oxyphilic / Q000378:metabolism / Q000473:pathology*; D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000378:metabolism / Q000473:pathology*; D002467:Cell Nucleus / Q000378:metabolism / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000378:metabolism / Q000473:pathology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012737:Sex Factors