title: Advances in cell-based therapy for peripheral vascular disease.
abstract: Evidence is accumulating to support cell-based therapies as a new approach for chronic diseases. Perhaps the area of greatest impact, in terms of patient numbers, is cardiovascular disorders. This review considers cell transplantation as a potential treatment for peripheral vascular disease, including ischemic stroke and erectile dysfunction. Bone marrow derived cells are required for endogenous repair in adult individuals affected by angiopathies. Clinical trials using progenitor cells generated from monocytic or non-monocytic cells indicate that both are effective, suggesting that angiogenesis is the result of cross talk between different cells and pathways. Currently, there are 14 registered clinical trials (ClinicalTrials.gov) examining different approaches to stem cell therapy to cure peripheral artery disease, of which 6 have completed enrollment. Here, we will review published clinical studies that used cell transplantation for peripheral vascular ischemic disorders.
authors.affiliation: Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL 33136 USA.
authors.forename: Arnon
authors.initials: A
authors.lastname: Blum
authors.forename: Wayne
authors.initials: W
authors.lastname: Balkan
authors.forename: Joshua M
authors.initials: JM
authors.lastname: Hare
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000503:physiopathology / Q000601:surgery; D007172:Erectile Dysfunction / Q000503:physiopathology / Q000601:surgery; D005260:Female; D006801:Humans; D007511:Ischemia / Q000503:physiopathology / Q000601:surgery; D035002:Lower Extremity / Q000098:blood supply*; D008297:Male; D018919:Neovascularization, Physiologic; D016491:Peripheral Vascular Diseases / Q000453:epidemiology / Q000503:physiopathology / Q000601:surgery*; D012038:Regeneration; D018570:Risk Assessment; D012307:Risk Factors; D033581:Stem Cell Transplantation / Q000009:adverse effects / Q000639:trends*; D013997:Time Factors; D016896:Treatment Outcome