title: Reversible posterior leukoencephalopathy syndrome after carboplatin and paclitaxel regimen for lung cancer.
abstract: Reversible posterior leukoencephalopathy syndrome (RPLS) is uncommon neurological syndrome that is characterized by specific clinical and radiologic findings. Previous reported associations of RPLS include hypertension, eclampsia, renal impairment and drugs. Prompt diagnosis and therapy is critical to ensure resolution of the neurological disability. Some cases have been reported in association with the increased use of antineoplastic agents in cancer patients. We report the case of a 62-year-old man who was diagnosed with RPLS after receiving carboplatin and paclitaxel chemotherapy for lung cancer. This case appears to be the first recognized association of RPLS with this regimen.
authors.affiliation: Department of Internal Medicine, Isesaki Municipal Hospital, Japan. m06701014@gunma-u.ac.jp
authors.forename: Hisao
authors.initials: H
authors.lastname: Imai
authors.forename: Nozomi
authors.initials: N
authors.lastname: Okuno
authors.forename: Shinichi
authors.initials: S
authors.lastname: Ishihara
authors.forename: Sachiko
authors.initials: S
authors.lastname: Nakano
authors.forename: Seiichi
authors.initials: S
authors.lastname: Higuchi
authors.forename: Tadashi
authors.initials: T
authors.lastname: Arai
authors.forename: Mari
authors.initials: M
authors.lastname: Tokunaga
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Taidoh
authors.initials: T
authors.lastname: Arai
authors.forename: Masatomo
authors.initials: M
authors.lastname: Mori
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects*; D016190:Carboplatin / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage / Q000009:adverse effects; D054038:Posterior Leukoencephalopathy Syndrome / Q000139:chemically induced* / Q000175:diagnosis*
chemical_list: D016190:Carboplatin; D017239:Paclitaxel