title: A new tumour suppressor enters the network of intestinal progenitor cell homeostasis.
abstract: In this issue of The EMBO Journal, Wilson et al (2012) elegantly discovered an important new axis for intestinal homeostasis and cancer, using an RNAi screen to enhance the RAS-induced multivulva (MUV) phenotype in Caenorhabditis elegans.
authors.affiliation: Beatson Insitute for Cancer Research, Glasgow, UK.
authors.forename: Ee Hong
authors.initials: EH
authors.lastname: Tan
authors.forename: Owen James
authors.initials: OJ
authors.lastname: Sansom
mesh_terms: D000818:Animals; D005260:Female; D006706:Homeostasis / Q000502:physiology*; D006801:Humans; D007422:Intestines / Q000502:physiology*; D047908:Intracellular Signaling Peptides and Proteins / Q000502:physiology*; D008297:Male; D010088:Oxidoreductases; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology*; D013234:Stem Cells / Q000502:physiology*; D025521:Tumor Suppressor Proteins / Q000235:genetics*; D033921:Vesicular Transport Proteins / Q000502:physiology*
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; C410809:NRBP1 protein, human; D018160:Receptors, Cytoplasmic and Nuclear; D025521:Tumor Suppressor Proteins; D033921:Vesicular Transport Proteins; C116084:Nrbf1 protein, mouse; D010088:Oxidoreductases