title: The ancient and evolving roles of cohesin in gene expression and DNA repair.
abstract: The cohesin complex, named for its key role in sister chromatid cohesion, also plays critical roles in gene regulation and DNA repair. It performs all three functions in single cell eukaryotes such as yeasts, and in higher organisms such as man. Minor disruption of cohesin function has significant consequences for human development, even in the absence of measurable effects on chromatid cohesion or chromosome segregation. Here we survey the roles of cohesin in gene regulation and DNA repair, and how these functions vary from yeast to man.
authors.affiliation: Edward A. Doisy Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, Saint Louis, MO 63104, USA. dorsettd@slu.edu
authors.forename: Dale
authors.initials: D
authors.lastname: Dorsett
authors.forename: Lena
authors.initials: L
authors.lastname: Ström
mesh_terms: D000818:Animals; D018797:Cell Cycle Proteins / Q000378:metabolism*; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism*; D004260:DNA Repair; D056890:Eukaryota / Q000254:growth & development / Q000378:metabolism; D015870:Gene Expression; D006801:Humans; D012854:Sister Chromatid Exchange; D000097722:Cohesins
chemical_list: D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; D000097722:Cohesins