title: Perspectives on developing small molecule inhibitors targeting HIV-1 integrase.
abstract: HIV-1 integrase (IN) is a crucial enzyme in the life cycle of HIV-1 and also a validated target for developing anti-HIV inhibitors. Recent progress in drug design has significantly accelerated the development of anti-AIDS IN inhibitors. A large amount of novel inhibitors that interact specifically with IN were developed along with the expanding and application of methods to drug design. This article reviewed the anti-HIV IN inhibitors discovered by the rational drug design approaches in the recent 5-year.
authors.affiliation: College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100124, China.
authors.forename: J J
authors.initials: JJ
authors.lastname: Tan
authors.forename: C
authors.initials: C
authors.lastname: Liu
authors.forename: X H
authors.initials: XH
authors.lastname: Sun
authors.forename: X J
authors.initials: XJ
authors.lastname: Cong
authors.forename: L M
authors.initials: LM
authors.lastname: Hu
authors.forename: C X
authors.initials: CX
authors.lastname: Wang
authors.forename: X J
authors.initials: XJ
authors.lastname: Liang
mesh_terms: D001665:Binding Sites; D015195:Drug Design; D055808:Drug Discovery / Q000639:trends*; D015658:HIV Infections / Q000188:drug therapy; D019427:HIV Integrase / Q000737:chemistry* / Q000378:metabolism; D019428:HIV Integrase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects* / Q000201:enzymology; D006801:Humans; D006860:Hydrogen Bonding; D008024:Ligands; D056004:Molecular Dynamics Simulation; D011485:Protein Binding; D054852:Small Molecule Libraries / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D019428:HIV Integrase Inhibitors; D008024:Ligands; D054852:Small Molecule Libraries; D019427:HIV Integrase; C514801:p31 integrase protein, Human immunodeficiency virus 1