title: IL-37 (IL-1F7) the newest anti-inflammatory cytokine which suppresses immune responses and inflammation.
abstract: Cytokines such as interleukins, chemokines and interferons are  immunomodulating and inflammatory agents, characterized by considerable  redundancy, in that many cytokines appear to share similar functions. Virtually all nucleated cells, but especially epithelial cells and macrophages, are potent producers of cytokines. The objective of this study is to review the detailed mechanism of action and the biological profiles of IL-37, the newest anti-inflammatory cytokine. This review focuses on IL-37, a key cytokine in regulating inflammatory responses, mainly by inhibiting the expression, production and function of proinflammatory cytokines: IL-1 family pro-inflammatory effects are markedly suppressed by IL-37.
authors.forename: S
authors.initials: S
authors.lastname: Tete
authors.forename: D
authors.initials: D
authors.lastname: Tripodi
authors.forename: M
authors.initials: M
authors.lastname: Rosati
authors.forename: F
authors.initials: F
authors.lastname: Conti
authors.forename: G
authors.initials: G
authors.lastname: Maccauro
authors.forename: A
authors.initials: A
authors.lastname: Saggini
authors.forename: E
authors.initials: E
authors.lastname: Cianchetti
authors.forename: A
authors.initials: A
authors.lastname: Caraffa
authors.forename: P
authors.initials: P
authors.lastname: Antinolfi
authors.forename: E
authors.initials: E
authors.lastname: Toniato
authors.forename: M L
authors.initials: ML
authors.lastname: Castellani
authors.forename: P
authors.initials: P
authors.lastname: Conti
authors.forename: T C
authors.initials: TC
authors.lastname: Theoharides
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D006801:Humans; D007375:Interleukin-1 / Q000037:antagonists & inhibitors / Q000494:pharmacology*
chemical_list: D000893:Anti-Inflammatory Agents; C508587:IL37 protein, human; D007375:Interleukin-1