title: A case of Klinefelter's syndrome with type 1 diabetes mellitus.
abstract: Klinefelter’s syndrome (KS) is the most common sex chromosome disease in men. Classical features of the syndrome include a eunuchoidal body habitus, small testes and hypergonadotrophic hypogonadism. There has been an increased risk of diabetes mellitus and autoimmune disease for KS patients. This paper reports a case of KS in association with type 1 diabetes mellitus. The patient was a 21-year-old man, who has been confirmed by absolute insulin deficiency and positive IA-2 autoantibody. The hyperinsulinemic euglycemic clamp test indicated his insulin sensitivity in normal range, and his blood glucose was controlled well by the insulin therapy.
authors.affiliation: Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, and Department of Endocrinology, China-Japan Friendship Hospital, Beijing 100730, China.
authors.forename: Xiao-pin
authors.initials: XP
authors.lastname: Cai
authors.forename: Li
authors.initials: L
authors.lastname: Zhao
authors.forename: Min
authors.initials: M
authors.lastname: Mao
authors.forename: Zhao-jun
authors.initials: ZJ
authors.lastname: Yang
authors.forename: Xiao-yan
authors.initials: XY
authors.lastname: Xing
authors.forename: Guang-wei
authors.initials: GW
authors.lastname: Li
mesh_terms: D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis* / Q000209:etiology*; D006801:Humans; D007713:Klinefelter Syndrome / Q000150:complications* / Q000175:diagnosis*; D008297:Male; D055815:Young Adult