title: Effect of berberine hydrochloride on grass carp Ctenopharyngodon idella serum bactericidal activity against Edwardsiella ictaluri.
abstract: Bactericidal activity of grass carp (Ctenopharyngodon idella) serum was significantly enhanced when pre-treated with 15 mg l⁻¹ or 3 mg l⁻¹ of berberine hydrochloride, an effective component of several commonly used herbal medicines in aquaculture. The complement consumption experiment demonstrated that berberine hydrochloride can certainly activate fish complement system. The results of both experiments suggested that berberine hydrochloride could enhance the serum bactericidal activity in grass carp by activating the complement system and indicating the potential in the prevention or treatment of fish diseases.
authors.affiliation: State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Donghu Road #7, Wuhan 430072, PR China.
authors.forename: Cheng
authors.initials: C
authors.lastname: Ji
authors.forename: De Feng
authors.initials: DF
authors.lastname: Zhang
authors.forename: Ai Hua
authors.initials: AH
authors.lastname: Li
authors.forename: Xiao Ning
authors.initials: XN
authors.lastname: Gong
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D001599:Berberine / Q000494:pharmacology*; D002347:Carps / Q000276:immunology*; D003165:Complement System Proteins / Q000378:metabolism; D020610:Edwardsiella ictaluri; D004756:Enterobacteriaceae Infections / Q000276:immunology / Q000662:veterinary*; D005393:Fish Diseases / Q000276:immunology*; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation / Q000187:drug effects; D015610:Serum Bactericidal Test
chemical_list: D000276:Adjuvants, Immunologic; D001599:Berberine; D003165:Complement System Proteins