title: Glycosaminoglycans in the urinary bladder mucosa, tumor tissue and mucosal tissue around tumor.
abstract: OBJECTIVE
  Glycosaminoglycans (GAG) are one of the main constituents of the connective tissue and cellular membrane. Their presence has been evidenced in mucosa and muscular tissue of the urinary bladder of both healthy individuals and those affected by carcinoma. This suggest their potential role in the onset of bladder carcinoma and follow-up of those patients. The aim of the study was to determine GAG levels in tumor tissue and the surrounding bladder mucosa in patients with bladder tumor, as well as in the bladder mucosa in patients with bladder carcinoma, and to compare the results according to the grade and stage of tumor and relapse.
  
  
  METHODS
  Tissue samples were taken in 61 patients (48 males and 13 females), mean age 61.5 years, range 40-92 years, obtained by transurethral resection (TUR) of bladder tumor, and 8 healthy persons. Determination of a total GAG content in the tissue samples was done by the Whiteman's method and then compared regarding the tumor grade and stage.
  
  
  RESULTS
  Tumor grade and stage directly correlated with the levels of GAG. The GAG levels were significantly higher in tumor samples as compared to healthy mucosa.
  
  
  CONCLUSIONS
  Higher GAG levels were recorded in all the patients with bladder tumors comparing to samples obtained from healthy individuals. GAG levels do not predict tumor relapse.
authors.affiliation: Faculty of Medicine, University of Belgrade, Belgrade, Serbia. bojanicnebojsa@gmail.com
authors.forename: Nebojsa
authors.initials: N
authors.lastname: Bojanić
authors.forename: Djordje
authors.initials: D
authors.lastname: Nale
authors.forename: Sava
authors.initials: S
authors.lastname: Mićić
authors.forename: Natasa
authors.initials: N
authors.lastname: Lalić
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Vuksanović
authors.forename: Cane
authors.initials: C
authors.lastname: Tulić
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006025:Glycosaminoglycans / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000378:metabolism; D001743:Urinary Bladder / Q000378:metabolism* / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D006025:Glycosaminoglycans