title: Optical coherence photoacoustic microscopy: accomplishing optical coherence tomography and photoacoustic microscopy with a single light source.
abstract: We developed optical coherence photoacoustic microscopy (OC-PAM) to demonstrate that the functions of optical coherence tomography (OCT) and photoacoustic microscopy (PAM) can be achieved simultaneously by using a single illuminating light source. We used a pulsed broadband laser centered at 580 nm and detected the absorbed photons through photoacoustic detection and the back-scattered photons with an interferometer. In OC-PAM, each laser pulse generates both one OCT A-line and one PAM A-line simultaneously; as a result, the two imaging modalities are intrinsically co-registered in the lateral directions. In vivo images of the mouse ear were acquired to demonstrate the capabilities of OC-PAM.
authors.forename: Xiangyang
authors.initials: X
authors.lastname: Zhang
authors.forename: Hao F
authors.initials: HF
authors.lastname: Zhang
authors.forename: Shuliang
authors.initials: S
authors.lastname: Jiao
mesh_terms: D000042:Absorption; D000818:Animals; D004423:Ear / Q000098:blood supply; D004867:Equipment Design; D007368:Interferometry; D007834:Lasers; D051379:Mice; D008853:Microscopy / Q000295:instrumentation* / Q000379:methods*; D061088:Photoacoustic Techniques / Q000295:instrumentation* / Q000379:methods*; D017785:Photons; D041623:Tomography, Optical Coherence / Q000295:instrumentation* / Q000379:methods*