title: Does lipid emulsion reduce amphotericin B nephrotoxicity? A systematic review and meta-analysis.
abstract: This meta-analysis of 13 studies revealed that amphotericin B delivered as a locally prepared lipid emulsion or in liposomes reduced nephrotoxicity to a similar degree, by 18.4% (relative risk [RR], 0.40 [99% confidence interval, .25-.64]; n = 459) and 18.1% (RR, 0.48 [99% CI, .36-.64]); n = 1233), respectively.
authors.affiliation: Federal University of Bahia, University Hospital Prof. Edgard Santos, Salvador-Bahia, Brazil. smistro@ufba.br
authors.forename: Sóstenes
authors.initials: S
authors.lastname: Mistro
authors.forename: Isis de M
authors.initials: Ide M
authors.lastname: Maciel
authors.forename: Rouseli G
authors.initials: RG
authors.lastname: de Menezes
authors.forename: Zuinara P
authors.initials: ZP
authors.lastname: Maia
authors.forename: Robert T
authors.initials: RT
authors.lastname: Schooley
authors.forename: Roberto
authors.initials: R
authors.lastname: Badaró
mesh_terms: D000666:Amphotericin B / Q000008:administration & dosage* / Q000009:adverse effects*; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000009:adverse effects*; D006801:Humans; D015994:Incidence; D007674:Kidney Diseases / Q000139:chemically induced*
chemical_list: D000935:Antifungal Agents; C068538:liposomal amphotericin B; D000666:Amphotericin B