title: Autoimmune disease-associated CD226 gene variants are not involved in giant cell arteritis susceptibility in the Spanish population.
abstract: OBJECTIVE
  CD226 genetic variants have been associated with a number of autoimmune diseases. The aim of this study was to investigate the potential implication of the CD226 loci in the susceptibility to and main clinical manifestations of giant cell arteritis (GCA).
  
  
  METHODS
  A Spanish Caucasian cohort of 455 patients diagnosed with biopsy-proven GCA and 1414 healthy controls were included in the study. Three CD226 polymorphisms, rs727088, rs34794968 and rs763361, were genotyped using the TaqMan® allelic discrimination technology. PLINK software was used for the statistical analyses.
  
  
  RESULTS
  No significant association between the CD226 polymorphisms and susceptibility to GCA was found (rs727088: p=0.92, OR=1.01, CI 95% 0.86-1.18; rs34794968: p=0.61, OR=1.04, CI 95% 0.89-1.22; rs763361: p=0.88, OR=0.99, CI 95% 0.84-1.16). Similarly, when patients were stratified according to the specific clinical features of GCA such as polymyalgia rheumatica, visual ischaemic manifestations or irreversible occlusive disease, no association was observed either between the case subgroups and the control set or between GCA patients with and without the specific features of the disease. Furthermore, the haplotype analysis revealed no significant association with the clinical manifestations of the disease.
  
  
  CONCLUSIONS
  Our results show that the three CD226 polymorphisms analysed do not play a relevant role in the susceptibility to GCA and clinical manifestations of this vasculitis.
authors.affiliation: Instituto de Parasitología y Biomedicina López-Neyra, CSIC, Granada, Spain. auroraselo@ipb.csic.es
authors.forename: Aurora
authors.initials: A
authors.lastname: Serrano
authors.forename: F David
authors.initials: FD
authors.lastname: Carmona
authors.forename: José A
authors.initials: JA
authors.lastname: Miranda-Filloy
authors.forename: Santos
authors.initials: S
authors.lastname: Castañeda
authors.forename: Luis
authors.initials: L
authors.lastname: Rodríguez-Rodríguez
authors.forename: Inmaculada C
authors.initials: IC
authors.lastname: Morado
authors.forename: Carmen
authors.initials: C
authors.lastname: Gómez-Vaquero
authors.forename: Roser
authors.initials: R
authors.lastname: Solans
authors.forename: Bernardo
authors.initials: B
authors.lastname: Sopeña
authors.forename: Ricardo
authors.initials: R
authors.lastname: Blanco
authors.forename: Ainhoa
authors.initials: A
authors.lastname: Unzurrunzaga
authors.forename: Norberto
authors.initials: N
authors.lastname: Ortego-Centeno
authors.forename: Begoña
authors.initials: B
authors.lastname: Marí-Alfonso
authors.forename: Eugenio
authors.initials: E
authors.lastname: de Miguel
authors.forename: Ana
authors.initials: A
authors.lastname: Hidalgo-Conde
authors.forename: Javier
authors.initials: J
authors.lastname: Martín
authors.forename: Miguel A
authors.initials: MA
authors.lastname: González-Gay
mesh_terms: D000368:Aged; D000945:Antigens, Differentiation, T-Lymphocyte / Q000235:genetics*; D015551:Autoimmunity / Q000235:genetics*; D001706:Biopsy; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D005787:Gene Frequency; D005820:Genetic Testing; D013700:Giant Cell Arteritis / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D006239:Haplotypes; D006801:Humans; D008297:Male; D016017:Odds Ratio; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D060888:Real-Time Polymerase Chain Reaction; D018570:Risk Assessment; D012307:Risk Factors; D013030:Spain / Q000453:epidemiology; D000098862:T Lineage-Specific Activation Antigen 1
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; D000098862:T Lineage-Specific Activation Antigen 1