title: Effects of magnesium sulphate on postoperative coagulation, measured by rotational thromboelastometry (ROTEM(®)).
abstract: We investigated the effects of magnesium sulphate on blood coagulation profiles using rotational thromboelastometry in gynaecological patients undergoing pelviscopic surgery. Patients were randomly allocated to the magnesium group (n = 20) or control group (n = 20). The magnesium group received magnesium sulphate (50 mg.kg(-1) followed by continuous infusion of 15 mg.kg(-1).h(-1)), whereas the control group received the same volume of isotonic saline according to the same methods. Mean (SD) postoperative serum magnesium levels were 1.58 (0.17) mmol.l(-1) in the magnesium group compared with 0.98 (0.06) mmol.l(-1) in the control group (p < 0.001). Postoperative clotting time, clot formation time, α-angle and maximum clot firmness of INTEM, and clot formation time, α-angle, and maximum clot firmness of EXTEM were significantly different between the two groups (p < 0.05). Intra-operative infusion of magnesium sulphate seems to attenuate postoperative hypercoagulability by maintaining magnesium levels at the upper limit of the normal range.
authors.affiliation: Department of Anaesthesiology and Pain Medicine, Seoul National University Bundang Hospital, Seongnam-si, Gyeonggi-do, South Korea.
authors.forename: H S
authors.initials: HS
authors.lastname: Na
authors.forename: Y H
authors.initials: YH
authors.lastname: Chung
authors.forename: J W
authors.initials: JW
authors.lastname: Hwang
authors.forename: S H
authors.initials: SH
authors.lastname: Do
mesh_terms: D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects*; D004311:Double-Blind Method; D006801:Humans; D008278:Magnesium Sulfate / Q000494:pharmacology*; D011183:Postoperative Complications / Q000517:prevention & control*; D013916:Thrombelastography / Q000379:methods*; D019851:Thrombophilia / Q000517:prevention & control*
chemical_list: D008278:Magnesium Sulfate