title: [A preliminary study on the genetic mode of aggressive periodontitis in Chinese Han nationality].
abstract: OBJECTIVE
  To investigate the potential genetic mode of aggressive periodontitis (AgP) in Chinese Han nationality.
  
  
  METHODS
  A total of 233 subjects from 73 nuclear families were recruited. All probands were diagnosed according to the criteria of AgP in 1999 classification of periodontal diseases. Ninety parents, 35 siblings and three grandparents and two offspring were examined based on full-mouth periodontal chartings (including parameter of probing depths, attachment loss, bleeding on probing at six sites per tooth) and full-mouth periapical radiographs. The genetic ratio was calculated and analyzed by the methods of Edwards and simple segregation.
  
  
  RESULTS
  The prevalence of AgP in probands' siblings was close to the square root of the prevalence of general population. The segregation ratio was 0.2419, which was close to the theoretical ratio for autosomal recessive inheritance. However, autosomal dominant inheritance could not be rejected in families whose parent(s) suffered from severe chronic periodontitis.
  
  
  CONCLUSIONS
  The genetic heterogeneity of AgP existed in Chinese Han nationality. The genetic mode was autosomal recessive inheritance in general, and autosomal dominant inheritance could not be excluded in families whose parent(s) suffered from severe chronical periodontitis. The results imply the genetic heterogeneity of AgP, and further demonstrate that AgP was a multifactorial disease with major genetic component in the disease etiology.
authors.affiliation: Department of Periodontology, Peking University School and Hospital of Stomatology, Beijing, China.
authors.forename: Xiu-yun
authors.initials: XY
authors.lastname: Ren
authors.forename: Li
authors.initials: L
authors.lastname: Xu
authors.forename: Huan-xin
authors.initials: HX
authors.lastname: Meng
authors.forename: Rui-fang
authors.initials: RF
authors.lastname: Lu
authors.forename: Zhi-bin
authors.initials: ZB
authors.lastname: Chen
authors.forename: Xiang-hui
authors.initials: XH
authors.lastname: Feng
mesh_terms: D010520:Aggressive Periodontitis / Q000453:epidemiology / Q000235:genetics*; D044466:Asian People / Q000235:genetics; D055113:Chronic Periodontitis / Q000453:epidemiology / Q000235:genetics; D005260:Female; D005799:Genes, Dominant; D005808:Genes, Recessive; D018740:Genetic Heterogeneity; D006801:Humans; D008297:Male; D010375:Pedigree; D015995:Prevalence; D011795:Surveys and Questionnaires