title: [Efficacy of local steroid injection on rat skin lesions induced by extravasation of vesicant anticancer drugs].
abstract: The efficacy of local steroid injection on the extravasation of vesicant anticancer drugs is controversial. In this study, the efficacy of local steroid injection was evaluated macroscopically and histologically in the extravasation models of doxorubicin (DXR), vinorelbine (VNR), and paclitaxel (PTX)in rats. Macroscopically, gross skin lesions were reduced by local steroid injections in rats treated with DXR and VNR. PTX did not cause gross skin lesions in most rats regardless of local steroid injection. Histologically, however, DXR, VNR, and PTX all induced deep tissue lesions such as edema, inflammation, and necrosis. Therefore, the effect of local steroid injection seemed to be minimal. In particular, DXR induced extensive necrosis in the subcutaneous and muscle tissues. VNR-induced skin lesions were milder than those induced by DXR, but had full thickness. Lesions caused by PTX were the mildest. These findings suggest that although local steroid injections could serve a primary role in diluting anticancer drugs and reducing gross skin lesions by their anti-inflammatory effect, they have less ability for suppressing deep-tissue lesions developing over time.
authors.affiliation: Dept. of Pharmacy, Teikyo University Hospital.
authors.forename: Masakazu
authors.initials: M
authors.lastname: Sugimoto
authors.forename: Makoto
authors.initials: M
authors.lastname: Yamamoto
authors.forename: Tomoya
authors.initials: T
authors.lastname: Mukouyama
authors.forename: Chiemi
authors.initials: C
authors.lastname: Ono
authors.forename: Masahiko
authors.initials: M
authors.lastname: Yasuda
authors.forename: Tomoko
authors.initials: T
authors.lastname: Shimada
authors.forename: Taizan
authors.initials: T
authors.lastname: Suzuki
authors.forename: Nobuyuki
authors.initials: N
authors.lastname: Kamo
authors.forename: Chizuko
authors.initials: C
authors.lastname: Shiga
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Hosono
authors.forename: Fumio
authors.initials: F
authors.lastname: Itagaki
authors.forename: Machiko
authors.initials: M
authors.lastname: Watanabe
authors.forename: Tadashi
authors.initials: T
authors.lastname: Ikeda
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000009:adverse effects*; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000188:drug therapy*; D007271:Injections, Intradermal; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013256:Steroids / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D013256:Steroids