title: Graphene-oxide-based immunosensing through fluorescence quenching by peroxidase-catalyzed polymerization.
abstract: A graphene oxide (GO)-based immunosensor is developed for the detection of interleukin-5 (IL-5), a key cytokine associated with asthma pathology and eosinophilia. The immunosensing platform utilizes the innate fluorescence of GO, not demanding biomolecules labeled with fluorescent dyes. The GO-based immunoassay exhibits high specificity for IL-5 among other cytokines and is not affected by nonspecific proteins in human serum.
authors.affiliation: Department of Materials Science and Engineering, Korea Advanced Institute of Science and Technology, 335 Science Road, Daejeon, Korea.
authors.forename: Seong Yoon
authors.initials: SY
authors.lastname: Lim
authors.forename: Junhyoung
authors.initials: J
authors.lastname: Ahn
authors.forename: Joon Seok
authors.initials: JS
authors.lastname: Lee
authors.forename: Min-Gon
authors.initials: MG
authors.lastname: Kim
authors.forename: Chan Beum
authors.initials: CB
authors.lastname: Park
mesh_terms: D015374:Biosensing Techniques / Q000379:methods*; D006108:Graphite / Q000737:chemistry*; D036103:Nanotechnology / Q000379:methods*; D009195:Peroxidase / Q000378:metabolism*; D058105:Polymerization
chemical_list: D006108:Graphite; D009195:Peroxidase