title: Reducing transfusion-related acute lung injury risk: evidence for and approaches to transfusion-related acute lung injury mitigation.
abstract: Transfusion-related acute lung injury (TRALI) is a major cause of transfusion-related morbidity and mortality. Although the pathogenesis of TRALI is incompletely understood, substantial data from hemovigilance systems, large case series, clinical trials, and animal models have identified antileukocyte antibodies as a major precipitant and have contributed to the development of concrete interventions to reduce the risk of TRALI. This review presents the clinical data supporting specific donor management strategies to reduce TRALI risk and their observed clinical efficacy. Novel strategies that use the donor health questionnaire combined with testing are discussed, and important challenges that remain going forward are explored.
authors.affiliation: Blood Transfusion Service, Department of Pathology, Massachusetts General Hospital, Boston, MA 02114-2696, USA. rmakar@partners.org
authors.forename: Robert S
authors.initials: RS
authors.lastname: Makar
authors.forename: Amy
authors.initials: A
authors.lastname: Powers
authors.forename: Christopher P
authors.initials: CP
authors.lastname: Stowell
mesh_terms: D055371:Acute Lung Injury / Q000209:etiology* / Q000517:prevention & control; D000818:Animals; D000906:Antibodies / Q000737:chemistry; D058731:Blood Safety; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000276:immunology*; D008297:Male; D011817:Rabbits; D016032:Randomized Controlled Trials as Topic; D012128:Respiratory Distress Syndrome / Q000209:etiology; D012306:Risk; D012307:Risk Factors; D011795:Surveys and Questionnaires; D065227:Transfusion Reaction
chemical_list: D000906:Antibodies