title: Electrical control of protein conformation.
abstract: Conducting polymer devices that enable precise control of fibronectin conformation over macroscopic areas are reported. Single conformations as well as conformation gradients are achieved by applying an appropriate potential. These surfaces remain biologically relevant and support cell culture; hence, they may serve as a model to understand and control cell-surface interactions, with applications in basic research, medical diagnostics, and tissue engineering.
authors.affiliation: Department of Materials Science and Engineering, Cornell University, Ithaca, NY 14853, USA.
authors.forename: Alwin M D
authors.initials: AM
authors.lastname: Wan
authors.forename: Rebecca M
authors.initials: RM
authors.lastname: Schur
authors.forename: Christopher K
authors.initials: CK
authors.lastname: Ober
authors.forename: Claudia
authors.initials: C
authors.lastname: Fischbach
authors.forename: Delphine
authors.initials: D
authors.lastname: Gourdon
authors.forename: George G
authors.initials: GG
authors.lastname: Malliaras
mesh_terms: D016475:3T3 Cells; D000818:Animals; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry; D004560:Electricity; D005353:Fibronectins / Q000737:chemistry* / Q000378:metabolism; D031541:Fluorescence Resonance Energy Transfer; D051379:Mice; D011108:Polymers / Q000737:chemistry; D011487:Protein Conformation; D044968:Regenerative Medicine; D013499:Surface Properties; D023822:Tissue Engineering
chemical_list: D019086:Bridged Bicyclo Compounds, Heterocyclic; D005353:Fibronectins; D011108:Polymers; C121383:poly(3,4-ethylene dioxythiophene)