title: Inflammation and clinical presentation in neurodegenerative disease: a volatile relationship.
abstract: A proposed immune mechanism that potentially modifies or exacerbates neurodegenerative disease presentation in older adults has received considerable attention in the past decade, with recent studies demonstrating a strong link between pro-inflammatory markers and neurodegeneration. The overarching aim of the following review is to synthesize recent research that supports a possible relationship between inflammation and clinical features of neurodegenerative diseases, including risk of development, cognitive and clinical correlates, and progression of the specified diseases. Specific emphasis is placed on providing a temporal context for the association between inflammation and neurodegeneration.
authors.affiliation: Neurology Department, Memory and Aging Center, University of California, San Francisco, CA 94143-1207, USA. bbettcher@memory.ucsf.edu
authors.forename: Brianne Magouirk
authors.initials: BM
authors.lastname: Bettcher
authors.forename: Joel H
authors.initials: JH
authors.lastname: Kramer
mesh_terms: D003072:Cognition Disorders / Q000209:etiology; D004660:Encephalitis / Q000209:etiology*; D006801:Humans; D019636:Neurodegenerative Diseases / Q000150:complications* / Q000276:immunology*; D013997:Time Factors