title: Computational analysis of axonal transport: a novel assessment of neurotoxicity, neuronal development and functions.
abstract: Axonal transport plays a crucial role in neuronal morphogenesis, survival and function. Despite its importance, however, the molecular mechanisms of axonal transport remain mostly unknown because a simple and quantitative assay system for monitoring this cellular process has been lacking. In order to better characterize the mechanisms involved in axonal transport, we formulate a novel computer-assisted monitoring system of axonal transport. Potential uses of this system and implications for future studies will be discussed.
authors.affiliation: Department of Molecular Pharmacology and Neurobiology, Yokohama City University, Graduate School of Medicine, Yokohama 236-0004, Japan.
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Goshima
authors.affiliation: Department of Molecular Pharmacology and Neurobiology, Yokohama City University, Graduate School of Medicine, Yokohama 236-0004, Japan.
authors.forename: Tomonobu
authors.initials: T
authors.lastname: Hida
authors.affiliation: Graduate School of Environment and Information Sciences, Yokohama National University, Yokohama 240-8501, Japan.
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Gotoh
mesh_terms: D000818:Animals; D001370:Axonal Transport / Q000187:drug effects / Q000502:physiology*; D002470:Cell Survival; D002642:Chick Embryo; D019295:Computational Biology; D007091:Image Processing, Computer-Assisted; D008959:Models, Neurological; D009414:Nerve Growth Factors / Q000502:physiology; D009415:Nerve Net / Q000254:growth & development / Q000502:physiology; D055495:Neurogenesis / Q000502:physiology; D009473:Neuronal Plasticity; D009474:Neurons / Q000166:cytology / Q000502:physiology; D009498:Neurotoxins / Q000633:toxicity
chemical_list: D009414:Nerve Growth Factors; D009498:Neurotoxins