title: Efficient γ-amino-proline-derived cell penetrating peptide-superparamagnetic iron oxide nanoparticle conjugates via aniline-catalyzed oxime chemistry as bimodal imaging nanoagents.
abstract: Aniline-catalyzed oxime chemistry was employed to conjugate a γ-amino-proline-derived cell penetrating peptide to superparamagnetic iron oxide nanoparticles (SPIONs). Internalization of the novel nanoconjugate into HeLa cells was found to be remarkably higher compared to the analogous TAT-SPION conjugate.
authors.affiliation: CIBER-BBN, Networking Centre on Bioengineering, Biomaterials, and Nanomedicine, 08028 Barcelona, Spain. silviacavalliIRB@gmail.com
authors.forename: Silvia
authors.initials: S
authors.lastname: Cavalli
authors.forename: Daniel
authors.initials: D
authors.lastname: Carbajo
authors.forename: Milena
authors.initials: M
authors.lastname: Acosta
authors.forename: Silvia
authors.initials: S
authors.lastname: Lope-Piedrafita
authors.forename: Ana Paula
authors.initials: AP
authors.lastname: Candiota
authors.forename: Carles
authors.initials: C
authors.lastname: Arús
authors.forename: Miriam
authors.initials: M
authors.lastname: Royo
authors.forename: Fernando
authors.initials: F
authors.lastname: Albericio
mesh_terms: D000814:Aniline Compounds / Q000737:chemistry*; D002384:Catalysis; D057846:Cell-Penetrating Peptides / Q000737:chemistry / Q000378:metabolism*; D005290:Ferric Compounds / Q000737:chemistry*; D005434:Flow Cytometry; D006367:HeLa Cells; D006801:Humans; D058185:Magnetite Nanoparticles / Q000737:chemistry*; D018613:Microscopy, Confocal; D010091:Oximes / Q000737:chemistry*; D011392:Proline / Q000737:chemistry*
chemical_list: D000814:Aniline Compounds; D057846:Cell-Penetrating Peptides; D005290:Ferric Compounds; D058185:Magnetite Nanoparticles; D010091:Oximes; C000499:ferric oxide; D011392:Proline; C023650:aniline