title: Association analysis between HOXD9 genes and the development of developmental dysplasia of the hip in Chinese female Han population.
abstract: BACKGROUND
  Developmental dysplasia of the hip (DDH) is a congenital or acquired deformation or misalignment of the hip joint which affects mainly females. We hypothesized that HOXD9 gene could be regulated in acetabular size or shape and related in DDH developing.
  
  
  METHODS
  Two hundred and nine Chinese Han female DDH patients and 173 ethnic, age matched healthy female controls were genotyped for HOXD9 two tag SNPs using sequenom method.
  
  
  RESULTS
  One of the two tag SNPs, rs711822, was not shown significantly differences in genotypic or allelic distribution between case and control group. Comparing the genotypic distribution of rs711819, there was significant differences between DDH patients group and control group (χ² = 7.54, df =2, P =0.023), and the association to DDH developing reached significance (P =0.045, OR =1.79, 95 % CI: 1.01-3.17 by dominant mode).
  
  
  CONCLUSIONS
  In conclusion, the association between one tag SNP of HOXD9 gene and the development of DDH reach significant in our study population, this result indicate the positive correlation between HOXD9 gene and DDH developing. Further study in larger sample size and different population as well as functional studies will help to understand the pathogenesis of DDH.
authors.affiliation: 1Tianjing medical University, Tianjing, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Tian
authors.forename: Lixi
authors.initials: L
authors.lastname: Zhao
authors.forename: Jing
authors.initials: J
authors.lastname: Wang
authors.forename: Peisu
authors.initials: P
authors.lastname: Suo
authors.forename: Jianmin
authors.initials: J
authors.lastname: Wang
authors.forename: Longfei
authors.initials: L
authors.lastname: Cheng
authors.forename: Zhi
authors.initials: Z
authors.lastname: Cheng
authors.forename: Jian
authors.initials: J
authors.lastname: Jia
authors.forename: Shilian
authors.initials: S
authors.lastname: Kan
authors.forename: Binbin
authors.initials: B
authors.lastname: Wang
authors.forename: Xu
authors.initials: X
authors.lastname: Ma
mesh_terms: D044466:Asian People / Q000235:genetics*; D002681:China / Q000208:ethnology; D005260:Female; D056726:Genetic Association Studies / Q000379:methods*; D020022:Genetic Predisposition to Disease; D006618:Hip Dislocation, Congenital / Q000208:ethnology / Q000235:genetics*; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D007223:Infant; D009363:Neoplasm Proteins / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*
chemical_list: C088822:HOXD9 protein, human; D018398:Homeodomain Proteins; D009363:Neoplasm Proteins