title: Metabolic effects of replacing sucrose by isomaltulose in subjects with type 2 diabetes: a randomized double-blind trial.
abstract: OBJECTIVE
  To test the hypothesis that replacement of sucrose with isomaltulose in sweet foods and beverages improves metabolic control in patients with type 2 diabetes.
  
  
  METHODS
  One hundred ten patients with type 2 diabetes were randomized to receive sweet foods containing either 50 g/day isomaltulose or sucrose for 12 weeks as part of their habitual diet under free-living conditions. HbA(1c) at 12 weeks was the primary outcome parameter.
  
  
  RESULTS
  In the final analysis comprising 101 patients, isomaltulose did not significantly affect HbA(1c) at 12 weeks (sucrose: 7.39 ± 0.78%; isomaltulose: 7.24 ± 0.76%; regression coefficient [b]: 0.02 [95% CI: -0.21 to 0.25], P = 0.844). Triglycerides at 12 weeks were significantly lower in the isomaltulose versus the sucrose group (b: 34.01 [6.59-61.44], P = 0.016). Other secondary parameters did not significantly differ between groups.
  
  
  CONCLUSIONS
  Isomaltulose did not influence glycemic control assessed as HbA(1c) in type 2 diabetes under free-living conditions but was associated with lower triglyceride levels.
authors.affiliation: Else Kröner-Fresenius-Center for Nutritional Medicine, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
authors.forename: Stefanie
authors.initials: S
authors.lastname: Brunner
authors.forename: Ines
authors.initials: I
authors.lastname: Holub
authors.forename: Stephan
authors.initials: S
authors.lastname: Theis
authors.forename: Andrea
authors.initials: A
authors.lastname: Gostner
authors.forename: Ralph
authors.initials: R
authors.lastname: Melcher
authors.forename: Petra
authors.initials: P
authors.lastname: Wolf
authors.forename: Ulrike
authors.initials: U
authors.lastname: Amann-Gassner
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Scheppach
authors.forename: Hans
authors.initials: H
authors.lastname: Hauner
mesh_terms: D000293:Adolescent; D000328:Adult; D001628:Beverages; D001786:Blood Glucose / Q000378:metabolism*; D002182:Candy; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000178:diet therapy; D004311:Double-Blind Method; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D057187:Independent Living; D007534:Isomaltose / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology; D008297:Male; D013395:Sucrose / Q000008:administration & dosage* / Q000097:blood / Q000494:pharmacology; D013549:Sweetening Agents / Q000008:administration & dosage* / Q000494:pharmacology; D014280:Triglycerides / Q000097:blood*; D055815:Young Adult
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007534:Isomaltose; D013395:Sucrose; D013549:Sweetening Agents; D014280:Triglycerides; C517652:hemoglobin A1c protein, human; C008189:isomaltulose