title: Role of SDF1/CXCR4 interaction in experimental hemiplegic models with neural cell transplantation.
abstract: Much attention has been focused on neural cell transplantation because of its promising clinical applications. We have reported that embryonic stem (ES) cell derived neural stem/progenitor cell transplantation significantly improved motor functions in a hemiplegic mouse model. It is important to understand the molecular mechanisms governing neural regeneration of the damaged motor cortex after the transplantation. Recent investigations disclosed that chemokines participated in the regulation of migration and maturation of neural cell grafts. In this review, we summarize the involvement of inflammatory chemokines including stromal cell derived factor 1 (SDF1) in neural regeneration after ES cell derived neural stem/progenitor cell transplantation in mouse stroke models.
authors.affiliation: Department of Immunology and Medicine, St. Marianna University School of Medicine, Sugao 2-16-1, Miyamae-ku, Kawasaki 216-8511, Japan.
authors.forename: Nagisa
authors.initials: N
authors.lastname: Arimitsu
authors.affiliation: Department of Immunology and Medicine, St. Marianna University School of Medicine, Sugao 2-16-1, Miyamae-ku, Kawasaki 216-8511, Japan.
authors.forename: Jun
authors.initials: J
authors.lastname: Shimizu
authors.affiliation: Department of Immunology and Medicine, St. Marianna University School of Medicine, Sugao 2-16-1, Miyamae-ku, Kawasaki 216-8511, Japan.
authors.forename: Naruyoshi
authors.initials: N
authors.lastname: Fujiwara
authors.affiliation: Department of Immunology and Medicine, St. Marianna University School of Medicine, Sugao 2-16-1, Miyamae-ku, Kawasaki 216-8511, Japan.
authors.forename: Kenji
authors.initials: K
authors.lastname: Takai
authors.affiliation: Department of Immunology and Medicine, St. Marianna University School of Medicine, Sugao 2-16-1, Miyamae-ku, Kawasaki 216-8511, Japan.
authors.forename: Erika
authors.initials: E
authors.lastname: Takada
authors.affiliation: Department of Neurosurgery, St. Marianna University School of Medicine, Sugao 2-16-1, Miyamae-ku, Kawasaki 216-8511, Japan.
authors.forename: Takao
authors.initials: T
authors.lastname: Kono
authors.affiliation: Department of Immunology and Medicine, St. Marianna University School of Medicine, Sugao 2-16-1, Miyamae-ku, Kawasaki 216-8511, Japan.
authors.forename: Yuji
authors.initials: Y
authors.lastname: Ueda
authors.affiliation: Department of Immunology and Medicine, St. Marianna University School of Medicine, Sugao 2-16-1, Miyamae-ku, Kawasaki 216-8511, Japan.
authors.forename: Tomoko
authors.initials: T
authors.lastname: Suzuki
authors.affiliation: Department of Immunology and Medicine, St. Marianna University School of Medicine, Sugao 2-16-1, Miyamae-ku, Kawasaki 216-8511, Japan.
authors.forename: Noboru
authors.initials: N
authors.lastname: Suzuki
mesh_terms: D000818:Animals; D054377:Chemokine CXCL12 / Q000378:metabolism*; D004195:Disease Models, Animal; D006429:Hemiplegia / Q000378:metabolism* / Q000473:pathology / Q000628:therapy*; D006801:Humans; D058953:Neural Stem Cells / Q000637:transplantation*; D011485:Protein Binding; D019718:Receptors, CXCR4 / Q000378:metabolism*
chemical_list: D054377:Chemokine CXCL12; D019718:Receptors, CXCR4