title: Large-scale solvent-free chlorination of hydroxy-pyrimidines, -pyridines, -pyrazines and -amides using equimolar POCl₃.
abstract: Chlorination with equimolar POCl₃ can be efficiently achieved not only for hydroxypyrimidines, but also for many other substrates such as 2-hydroxy-pyridines, -quinoxalines, or even -amides. The procedure is solvent-free and involves heating in a sealed reactor at high temperatures using one equivalent of pyridine as base. It is suitable for large scale (multigram) batch preparations.
authors.affiliation: School of Chemistry and Molecular Engineering, East China University of Science and Technology, Shanghai, 200237, China.
authors.forename: Han
authors.initials: H
authors.lastname: Wang
authors.forename: Kun
authors.initials: K
authors.lastname: Wen
authors.forename: Le
authors.initials: L
authors.lastname: Wang
authors.forename: Ye
authors.initials: Y
authors.lastname: Xiang
authors.forename: Xiaocheng
authors.initials: X
authors.lastname: Xu
authors.forename: Yongjia
authors.initials: Y
authors.lastname: Shen
authors.forename: Zhihua
authors.initials: Z
authors.lastname: Sun
mesh_terms: D000577:Amides / Q000737:chemistry*; D054879:Halogenation; D017553:Phosphorus Compounds / Q000737:chemistry*; D011725:Pyridines / Q000737:chemistry*; D011743:Pyrimidines / Q000737:chemistry*; D012997:Solvents; D013696:Temperature
chemical_list: D000577:Amides; D017553:Phosphorus Compounds; D011725:Pyridines; D011743:Pyrimidines; D012997:Solvents; C013196:phosphoryl chloride