title: Renal histology in pauci-immune rapidly progressive glomerulonephritis: 8-year retrospective study.
abstract: BACKGROUND
  The need to perform reporting of renal biopsies of antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitides in a more uniform manner required relook at our eight-year data.
  
  
  OBJECTIVE
  To document detailed renal histopathology of pauci-immune rapidly progressive glomerulonephritis (RPGN) and also to seek any significant differences in renal histology of C-ANCA-positive, P-ANCA-positive, and ANCA-negative patients.
  
  
  METHODS
  A detailed analysis of the histopathologic features of renal biopsies of 48 patients in whom a diagnosis of pauci-immune glomerulonephritis was concluded on renal biopsy and who presented clinically as rapidly progressive renal failure was done.
  
  
  METHODS
  One-way ANOVA and Pearson Chi square tests.
  
  
  RESULTS
  Compared with ANCA +ve patients, the ANCA -ve patients were much younger (46.85 ± 16.12 years vs 34.28±15.94 years). No significant differences were found between renal lesions of C-ANCA, P-ANCA, and ANCA-negative patients, except for diffuse tubular atrophy which was more severe and more frequently present with P-ANCA positivity (P value=0.013).
  
  
  CONCLUSIONS
  Pauci-immune RPGN (irrespective of ANCA status) is a relatively rare disorder in patients who are undergoing the renal biopsy at our institute, constituting 2% of all renal biopsies submitted. It is mandatory to have ANCA serology status during reporting of a kidney biopsy showing pauci-immune crescentic or necrotizing glomerulonephritis. Also, if a uniform reporting strategy is followed throughout the country, the studies from this vast country will be comparable.
authors.affiliation: Department of Immunopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: Ranjana W
authors.initials: RW
authors.lastname: Minz
authors.forename: Seema
authors.initials: S
authors.lastname: Chhabra
authors.forename: Kusum
authors.initials: K
authors.lastname: Joshi
authors.forename: Lekha
authors.initials: L
authors.lastname: Rani
authors.forename: Nidhi
authors.initials: N
authors.lastname: Sharma
authors.forename: Vinay
authors.initials: V
authors.lastname: Sakhuja
authors.forename: Rajan
authors.initials: R
authors.lastname: Duggal
authors.forename: Neelam
authors.initials: N
authors.lastname: Pasricha
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D056648:Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / Q000150:complications* / Q000473:pathology*; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D005260:Female; D005921:Glomerulonephritis / Q000473:pathology*; D006651:Histocytochemistry; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D007668:Kidney / Q000473:pathology*; D008297:Male; D008853:Microscopy; D008875:Middle Aged; D012189:Retrospective Studies
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic