title: [Maternal and fetal outcomes in systemic lupus erythematosus: analysis of 41 patients].
abstract: OBJECTIVE
  To evaluate the outcomes of pregnancies in patients with systemic lupus erythematosus (SLE).
  
  
  METHODS
  A retrospective observation  was made on 41 patients with SLE delivered in our hospital and the disease activity of the patients and neonatal conditions were followed up for one year  after delivery. The impact of the disease duration, the use of cyclophosphamide, the highest systematic lupus erythematosus disease activity index  (SLEDAI) score during the disease and the antepartum SLEDAI score to the outcome of delivery were analyzed.
  
  
  RESULTS
  The disease duration of SLE  was (3.5±3.1) years, the highest SLEDAI score during the disease was 10.6±3.1. The antepartum SLEDAI score was 6.2±1.6, the postpartum SLEDAI score  was 6.4±2.9. The SLEDAI score in one year after delivery was 5.4±2.1, which in patients with disease duration more than 4 years was higher than that in  patients with disease duration less than 4 years (P=0.03). All the deliveries were live births. The gestational age at birth was (37.6±3.3) weeks, and the body  weight was (2 510.0±756.9) g. These figures were significantly lower than those of the healthy women (P=0.03 and P=0.008, respectively). Four (9.8%)  newborns were diagnosed as neonatal lupus.
  
  
  CONCLUSIONS
  The risks of premature and low weight baby rates are increased in patients with SLE. The  proper timing of pregnancy and conception will improve pregnancy outcomes.
authors.affiliation: Department of Rheumatology, Peking University People's Hospital, Beijing100044, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Ye
authors.forename: Shi
authors.initials: S
authors.lastname: Chen
authors.forename: Yuan
authors.initials: Y
authors.lastname: An
mesh_terms: D000328:Adult; D002681:China / Q000453:epidemiology; D005260:Female; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000151:congenital / Q000453:epidemiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology*; D011256:Pregnancy Outcome; D047928:Premature Birth; D012189:Retrospective Studies; D055815:Young Adult