title: Novel therapeutic strategies for AML in 2012.
abstract: During the last four decades, much progress has been made in understanding the molecular pathogenesis of acute myeloid leukemia and in identifying prognostic factors predictive of outcome. However, progress in therapy has been much slower. Since the initial description  of the combination of an anthracycline and cytarabine for induction, few major advances have changed the standard of care. Furthermore, these few advances apply to younger patients and those with inherently more favorable disease biology. Intensification of post-remission cytarabine improves  the cure rate of patients in first complete remission (CR). Daunorubicin dose intensification improves outcome in younger patients. Finally, allogeneic hematopoietic cell transplantation is an effective strategy for many patients in first CR. The discovery of drugs with novel mechanisms of  action which are directly at specific molecular targets is among the most exciting areas of research and holds great promise for the development of effective treatment.
authors.affiliation: Department of Medicine, Leukemia Service, Memorial Sloan-Kettering Cancer Center, Weill Cornell Medical College, 1275 York Ave. Box 380, New York, NY 10065, USA. Tallmanm@mskcc.org
authors.forename: Martin S
authors.initials: MS
authors.lastname: Tallman
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D055808:Drug Discovery; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000235:genetics / Q000628:therapy*; D008875:Middle Aged; D009154:Mutation; D012074:Remission Induction
chemical_list: D000970:Antineoplastic Agents