title: Risk factors for early death in transient myeloproliferative disorder without phenotypic features of Down syndrome: a case report and literature review.
abstract: Not only in newborns with Down syndrome, but newborns without phenotypic features of Down syndrome also develop transient myeloproliferative disorder (TMD). In these cases, trisomy 21 and related chromosomal abnormalities are either constitutionally mosaic or limited to blood cells. Risk factors for early death of these patients are unknown so far. We here report a fatal case of TMD without phenotypic features of Down syndrome and review literature to identify risk factors associated with early death. Not only are gestational age and white blood cell count risk factors for early death in TMD with Down syndrome, but they also appear to be risk factors in TMD without Down syndrome.
authors.affiliation: Department of Pediatrics, Toyohashi Municipal Hospital, Toyohashi, Aichi, Japan. pisces-koya@yacht.ocn.ne.jp
authors.forename: Koya
authors.initials: K
authors.lastname: Kawase
authors.forename: Eiichi
authors.initials: E
authors.lastname: Azuma
authors.forename: Hironori
authors.initials: H
authors.lastname: Ohshita
authors.forename: Tatsushi
authors.initials: T
authors.lastname: Tanaka
authors.forename: Yu
authors.initials: Y
authors.lastname: Hanada
authors.forename: Tomoaki
authors.initials: T
authors.lastname: Sasaki
authors.forename: Mari
authors.initials: M
authors.lastname: Sugimoto
authors.forename: Takao
authors.initials: T
authors.lastname: Togawa
authors.forename: Masanori
authors.initials: M
authors.lastname: Kouwaki
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Ito
authors.forename: Masahiro
authors.initials: M
authors.lastname: Hirayama
authors.forename: Norihisa
authors.initials: N
authors.lastname: Koyama
mesh_terms: D002869:Chromosome Aberrations; D003645:Death, Sudden / Q000209:etiology*; D004314:Down Syndrome; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007958:Leukocyte Count; D009196:Myeloproliferative Disorders / Q000150:complications* / Q000401:mortality*; D010641:Phenotype; D011379:Prognosis; D012196:Review Literature as Topic; D012307:Risk Factors