title: Toll-like receptors (TLR2 and TLR4) recognize polysaccharides of Pseudallescheria boydii cell wall.
abstract: Pseudallescheria boydii is an opportunistic fungus widespread in the environment, and has recently emerged as an agent of localized as well as disseminated infections in both immunocompromised and immunocompetent hosts. The host response to fungi is in part dependent on the activation of evolutionary conserved receptors including Toll-like receptors and phagocytic receptors. This review will discuss the isolation and structural characterization of α-glucans and rhamnomannans from P. boydii cell wall and their roles in the induction of innate immune response.
authors.affiliation: Instituto de Ciências Biomédicas/Pólo de Xerém, Universidade Federal do Rio de Janeiro, Brazil.
authors.forename: Rodrigo Tinoco
authors.initials: RT
authors.lastname: Figueiredo
authors.forename: Vera Carolina B
authors.initials: VC
authors.lastname: Bittencourt
authors.forename: Lívia Cristina L
authors.initials: LC
authors.lastname: Lopes
authors.forename: Guilherme
authors.initials: G
authors.lastname: Sassaki
authors.forename: Eliana
authors.initials: E
authors.lastname: Barreto-Bergter
mesh_terms: D002473:Cell Wall / Q000737:chemistry / Q000276:immunology; D005936:Glucans / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D006801:Humans; D007113:Immunity, Innate; D008264:Macrophages / Q000276:immunology / Q000378:metabolism; D008351:Mannans / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D009000:Monocytes / Q000276:immunology / Q000378:metabolism; D009181:Mycoses / Q000276:immunology / Q000382:microbiology; D011541:Pseudallescheria / Q000737:chemistry* / Q000276:immunology; D021681:Scedosporium / Q000737:chemistry* / Q000276:immunology; D051195:Toll-Like Receptor 2 / Q000276:immunology / Q000378:metabolism*; D051197:Toll-Like Receptor 4 / Q000276:immunology / Q000378:metabolism*
chemical_list: D005936:Glucans; D008351:Mannans; D051195:Toll-Like Receptor 2; D051197:Toll-Like Receptor 4