title: Multiplex PCR for rapid and improved diagnosis of bloodstream infections in liver transplant recipients.
abstract: This prospective study evaluated the utility of the SeptiFast (SF) test in detecting 25 clinically important pathogens in 225 blood samples from 170 intensive care unit (ICU) patients with suspected sepsis after liver transplantation (LTX) or after other major abdominal surgery (non-LTX). SF yielded a significantly higher positivity rate in the LTX group (52.3%) than in the non-LTX group (30.5%; P = 0.0009). SF may be a powerful tool for the early diagnosis of bloodstream infections in LTX patients.
authors.affiliation: Institute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
authors.forename: Peter-Michael
authors.initials: PM
authors.lastname: Rath
authors.forename: Fuat
authors.initials: F
authors.lastname: Saner
authors.forename: Andreas
authors.initials: A
authors.lastname: Paul
authors.forename: Nils
authors.initials: N
authors.lastname: Lehmann
authors.forename: Eike
authors.initials: E
authors.lastname: Steinmann
authors.forename: Jan
authors.initials: J
authors.lastname: Buer
authors.forename: Joerg
authors.initials: J
authors.lastname: Steinmann
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008828:Microbiological Techniques / Q000379:methods*; D008875:Middle Aged; D060885:Multiplex Polymerase Chain Reaction / Q000379:methods*; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D018805:Sepsis / Q000175:diagnosis* / Q000382:microbiology*; D014180:Transplantation