title: Antinociceptive and anti-inflammatory effects of ethanol extract from Vernonia polyanthes leaves in Rodents.
abstract: The ethanol extract from Vernonia polyanthes leaves (EEVP) was investigated for antinociceptive and anti-inflammatory effects at the doses (p.o.) of 100, 200 and 400 mg/kg in animal models. The extract reduced the number of abdominal contortions by 16.75% and 31.44% at a dose of 200 and 400 mg/kg, respectively. The results obtained showed that EEVP exerted a significant antinociceptive effect in the two phases of formalin. The EEVP increased the reaction time on a hot plate at the doses of 100, 200 and 400 mg/kg after 90 min of treatment. The paw edema was reduced by EEVP at the doses of 100, 200 and 400 mg/kg after 4 h of application of carrageenan. Doses of 200 and 400 mg/kg, administered 4 h before the carrageenan injection, significantly reduced the exudate volume (29.25 and 45.74%, respectively) and leukocyte migration (18.19 and 27.95%, respectively). These results suggest that V. polyanthes can be an active source of substances with antinociceptive and anti-inflammatory activities.
authors.affiliation: Graduate Program in Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036-330, Brazil.
authors.forename: Vanessa
authors.initials: V
authors.lastname: Dos Santos Temponi
authors.affiliation: Graduate Program in Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036-330, Brazil.
authors.forename: Jucélia Barbosa
authors.initials: JB
authors.lastname: Da Silva
authors.affiliation: Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036-330, Brazil.
authors.forename: Maria Silvana
authors.initials: MS
authors.lastname: Alves
authors.affiliation: Department of Biochemistry, Institute of Biological Sciences, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora 36036-330, Brazil.
authors.forename: Antônia
authors.initials: A
authors.lastname: Ribeiro
authors.affiliation: Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036-330, Brazil.
authors.forename: José de Jesus Ribeiro Gomes de
authors.initials: JJRG
authors.lastname: Pinho
authors.affiliation: Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036-330, Brazil.
authors.forename: Célia Hitomi
authors.initials: CH
authors.lastname: Yamamoto
authors.affiliation: Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036-330, Brazil.
authors.forename: Miriam Aparecida Oliveira
authors.initials: MAO
authors.lastname: Pinto
authors.affiliation: Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036-330, Brazil.
authors.forename: Glauciemar
authors.initials: G
authors.lastname: Del-Vechio-Vieira
authors.affiliation: Department of Pharmaceutical Sciences, Faculty of Pharmacy, Federal University of Juiz de Fora, Campus Universitário, Juiz de Fora, Minas Gerais 36036-330, Brazil.
authors.forename: Orlando Vieira
authors.initials: OV
authors.lastname: De Sousa
mesh_terms: D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D002351:Carrageenan; D004487:Edema / Q000188:drug therapy; D000431:Ethanol / Q000737:chemistry; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D008297:Male; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy; D059408:Pain Management; D010147:Pain Measurement; D010936:Plant Extracts / Q000627:therapeutic use*; D018515:Plant Leaves / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D035741:Vernonia / Q000378:metabolism*
chemical_list: D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D000431:Ethanol; D002351:Carrageenan