title: An analysis of the relative risk for hypothyroidism in patients with Type 2 diabetes.
abstract: OBJECTIVE
  We aimed to assess the relative risk for hypothyroidism in patients with Type 2 diabetes.
  
  
  METHODS
  In this study, 1112 patients with Type 2 diabetes (58% women, mean age 66.7 years, median duration of diabetes 10 years, 179 with previous history of thyroid disease) and 911 subjects without diabetes were evaluated.
  
  
  RESULTS
  The gender-, age- and weight-adjusted relative risk (odds ratio) of newly identified hypothyroidism in patients with Type 2 diabetes in comparison with control subjects was 2.81 (1.77-4.48). This odds ratio was significant in patients over 65 years [4.02 (1.95-8.31)], as well as in both men [4.84 (1.58-14.80)] and women [2.60 (1.54-4.38)], in obese patients [2.56 (1.36-4.82)] and non-obese patients [3.11 (1.56-6.20)] and in individuals with [4.26 (1.73-10.46)] and without [2.93 (1.50-5.75)] thyroid autoantibodies. Logistic regression analysis showed that newly diagnosed hypothyroidism was significantly and directly related not only with thyroid autoimmunity [19.15 (8.73-42.01)], but also with the presence of macroangiopathy [2.85 (1.51-5.35)] and metformin treatment [2.51 (1.28-4.92)].
  
  
  CONCLUSIONS
  Our results favour screening for hypothyroidism in patients with Type 2 diabetes older than 65 years, especially in the presence of diabetic macroangiopathy or treatment with metformin.
authors.affiliation: Department of Endocrinology, Hospital Ramón y Cajal, Madrid, Spain. jdiez.hrc@salud.madrid.org
authors.forename: J J
authors.initials: JJ
authors.lastname: Díez
authors.forename: P
authors.initials: P
authors.lastname: Iglesias
mesh_terms: D000368:Aged; D001323:Autoantibodies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000188:drug therapy / Q000453:epidemiology; D005215:Fasting / Q000097:blood*; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007037:Hypothyroidism / Q000097:blood* / Q000453:epidemiology / Q000517:prevention & control; D016015:Logistic Models; D008297:Male; D008687:Metformin / Q000627:therapeutic use; D016017:Odds Ratio; D015995:Prevalence; D012306:Risk; D013972:Thyrotropin / Q000097:blood*; D013974:Thyroxine / Q000097:blood*
chemical_list: D001323:Autoantibodies; D007004:Hypoglycemic Agents; D013972:Thyrotropin; D008687:Metformin; D013974:Thyroxine