title: Risperidone-induced leukopenia: a case report and brief review of literature.
abstract: A Caucasian, male, young adult with recurrent agitated depression and suicidal ideation received lithium and oral olanzapine. His white blood cell count was normal at that time. Due to unsatisfactory response, he received 4 mg/day risperidone. While symptoms improved, leukopenia emerged, specifically directed towards neutrophils. Upon risperidone discontinuation, white blood cell count returned to reference values within 1 week. As symptom control was satisfactory, we attempted no risperidone rechallenge. Accurate blood testing must accompany atypical antipsychotic drug administration since blood dyscrasias are always possible with these drugs.
authors.affiliation: NESMOS Department (Neurosciences, Mental Health and Sense Organs), and Unit of Psychiatry, Sant'Andrea Hospital, Sapienza University-Rome, School of Medicine and Psychology, Rome, Italy.
authors.forename: Giovanni
authors.initials: G
authors.lastname: Manfredi
authors.forename: Andrea
authors.initials: A
authors.lastname: Solfanelli
authors.forename: Giorgia
authors.initials: G
authors.lastname: Dimitri
authors.forename: Ilaria
authors.initials: I
authors.lastname: Cuomo
authors.forename: Gabriele
authors.initials: G
authors.lastname: Sani
authors.forename: Giorgio D
authors.initials: GD
authors.lastname: Kotzalidis
authors.forename: Paolo
authors.initials: P
authors.lastname: Girardi
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects*; D003866:Depressive Disorder / Q000188:drug therapy*; D006801:Humans; D007970:Leukopenia / Q000139:chemically induced; D008297:Male; D009503:Neutropenia / Q000139:chemically induced*; D018967:Risperidone / Q000009:adverse effects*
chemical_list: D014150:Antipsychotic Agents; D018967:Risperidone