title: Influence of the distensibility of large arteries on the longitudinal impedance: application for the development of non-invasive techniques to the diagnosis of arterial diseases.
abstract: BACKGROUND
  This study shows that the arterial longitudinal impedance constitutes a hemodynamic parameter of interest for performance characterization of large arteries in normal condition as well as in pathological situations. For this purpose, we solved the Navier-Stokes equations for an incompressible flow using the finite element analysis method and the Arbitrary Lagrangian Eulerian (ALE) formulation. The mathematical model assumes a two-dimensional flow and takes into account the nonlinear terms in the equations of fluid motion that express the convective acceleration, as well as the nonlinear deformation of the arterial wall. Several numerical simulations of the blood flow in large vessels have been performed to study the propagation along an arterial vessel of a pressure gradient pulse and a rate flow pulse. These simulations include various deformations of the wall artery leading to parietal displacements ranging from 0 (rigid wall) to 15% (very elastic wall) in order to consider physiological and pathological cases.
  
  
  RESULTS
  The results show significant changes of the rate flow and the pressure gradient wave as a function of aosc, the relative variation in the radius of the artery over a cardiac cycle. These changes are notable beyond a critical value of aosc equal to 0.05. This critical value is also found in the evolution of the longitudinal impedance. So, above a variation of radius of 5%, the convective acceleration, created by the fluid-wall interactions, have an influence on the flow detectable on the longitudinal impedance.
  
  
  CONCLUSIONS
  The interpretation of the evolution of the longitudinal impedance shows that it could be a mean to test the performance of large arteries and can contribute to the diagnosis of parietal lesions of large arteries. For a blood vessel with a wall displacement higher than 5% similar to those of large arteries like the aorta, the longitudinal impedance is substantially greater than that obtained in the absence of wall displacement. This study also explains the effects of convective acceleration, on the shape of the decline of the pressure gradient wave and shows that they should not be neglected when the variation in radius is greater than 5%.
authors.affiliation: Biomedical Engineering Department, Higher Institute of Biotechnology of Sfax, Route de la Soukra BP261, 3032, Sfax, Tunisie.|Unit of research of Biophysics, Faculty of Medicine of Sousse, Sousse, Tunisie.
authors.forename: Wassila
authors.initials: W
authors.lastname: Sahtout
authors.affiliation: Unit of research of Biophysics, Faculty of Medicine of Sousse, Sousse, Tunisie.
authors.forename: Ridha Ben
authors.initials: RB
authors.lastname: Salah