title: Measurement of high-molecular-weight adiponectin is not useful in assessing coronary stenosis.
abstract: BACKGROUND
  In many studies, high-molecular-weight (HMW) adiponectin has been considered the active form of adiponectin. However, whether HMW adiponectin is a good surrogate marker for coronary artery disease still needs to be elucidated.
  
  
  METHODS
  We conducted a hospital-based cross-sectional study to examine the relationship between total, HMW or non-HMW adiponectin concentrations and coronary stenosis in 83 male patients and 138 male controls.
  
  
  RESULTS
  Patients with coronary stenosis had significantly lower total adiponectin concentrations compared with controls. Non-HMW adiponectin concentrations in cases were significantly lower than the controls. However, there were no significant differences between cases and controls in HMW adiponectin concentrations. From the receiver operating characteristic (ROC) analysis, the area under the curve (AUC) for total and non-HMW adiponectin was significantly larger than that for HMW adiponectin concentrations. Of the three models, that for non-HMW adiponectin showed the largest AUC (total adiponectin 0.74, HMW adiponectin 0.54, and non-HMW adiponectin 0.79).
  
  
  CONCLUSIONS
  Despite associations between total adiponectin levels and coronary stenosis, our data go against any apparent association between HMW adiponectin concentrations and coronary stenosis.
authors.affiliation: Faculty of Preventive Medicine and Public Health and School of Medicine, Fukuoka University, Fukuoka, Japan. imatoh@cis.fukuoka-u.ac.jp
authors.forename: Takuya
authors.initials: T
authors.lastname: Imatoh
authors.forename: Motonobu
authors.initials: M
authors.lastname: Miyazaki
authors.forename: Ken
authors.initials: K
authors.lastname: Kadowaki
authors.forename: Shinichi
authors.initials: S
authors.lastname: Tanihara
authors.forename: Chinami
authors.initials: C
authors.lastname: Akashi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Une
mesh_terms: D052242:Adiponectin / Q000097:blood* / Q000737:chemistry*; D016022:Case-Control Studies; D023921:Coronary Stenosis / Q000097:blood* / Q000175:diagnosis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D012372:ROC Curve
chemical_list: D052242:Adiponectin