title: On chemical structures with potent antiepileptic/anticonvulsant profile.
abstract: Epilepsy is a common chronic neurological disorder characterized by recurrent unprovoked seizures. There has been a considerable interest in the development of many antiepileptic and anticonvulsant agents for controlling epilepsy with fewer side effects and improvement of quality of life. Since the terms antiepileptics /anticonvulsants are used interchangeably, this article reviews their classification according to the chemical structure into: hydantoins, oxazolidinediones, succinimides, barbiturates, amides, benzodiazepines, valproic acid and its derivatives, GABA-analogues, cycloalkanes, semicarbazones, γ butyrolactones (GBLs), imidaquinazolines and pyrrolidine derivatives as well as miscellaneous compounds. In addition, the review discusses the different mechanisms of action of antiepileptic and anticonvulsant agents.
authors.affiliation: Medicinal and Pharmaceutical Chemistry Department, Pharmaceutical and Drug Industries Research Division, National Research Centre, Dokki, Cairo, Egypt. mnaboulenein@yahoo.com
authors.forename: M N
authors.initials: MN
authors.lastname: Aboul-Enein
authors.forename: A A
authors.initials: AA
authors.lastname: El-Azzouny
authors.forename: O A
authors.initials: OA
authors.lastname: Saleh
authors.forename: Y A
authors.initials: YA
authors.lastname: Maklad
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000737:chemistry* / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D012640:Seizures / Q000188:drug therapy / Q000378:metabolism
chemical_list: D000927:Anticonvulsants