title: [Estimating glomerular filtration rate in 2012: which adding value for the CKD-EPI equation?].
abstract: Measuring or estimating glomerular filtration rate (GFR) is still considered as the best way to apprehend global renal function. In 2009, the new Chronic Kidney Disease Epidemiology (CKD-EPI) equation has been proposed as a better estimator of GFR than the Modification of Diet in Renal Disease (MDRD) study equation. This new equation is supposed to underestimate GFR to a lesser degree in higher GFR levels. In this review, we will present and deeply discuss the performances of this equation. Based on articles published between 2009 and 2012, this review will underline advantages, notably the better knowledge of chronic kidney disease prevalence, but also limitations of this new equation, especially in some specific populations. We eventually insist on the fact that all these equations are estimations and nephrologists should remain cautious in their interpretation.
authors.affiliation: Service de Néphrologie-Dialyse-Transplantation, Université de Liège, CHU Sart-Tilman, 4000 Liège, Belgique. pierre_delanaye@yahoo.fr
authors.forename: Pierre
authors.initials: P
authors.lastname: Delanaye
authors.forename: Christophe
authors.initials: C
authors.lastname: Mariat
authors.forename: Olivier
authors.initials: O
authors.lastname: Moranne
authors.forename: Etienne
authors.initials: E
authors.lastname: Cavalier
authors.forename: Martin
authors.initials: M
authors.lastname: Flamant
mesh_terms: D003404:Creatinine / Q000097:blood*; D004032:Diet; D005919:Glomerular Filtration Rate; D006801:Humans; D055641:Mathematical Concepts; D015995:Prevalence; D051436:Renal Insufficiency, Chronic / Q000175:diagnosis* / Q000453:epidemiology
chemical_list: D003404:Creatinine