title: Clinical outcomes of patients with nonseminomatous germ cell tumours and negative postchemotherapy positron emission tomography.
abstract: Univariate and multivariate analyses were carried out to identify factors associated with the failure of 18-fluorodeoxyglucose positron emission tomography (FDG-PET) to correctly predict relapse-free survival in patients with nonseminomatous germ cell tumours. Ninety-three patients with negative postchemotherapy FDG-PET scan were analyzed in the retrospective study. The FDG-PET result was validated by long-term follow-up and, in some patients, by resection of the residual tumour mass. The negative predictive value of FDG-PET was 81.7%. Higher tumour marker levels and nodal stage at diagnosis, presence of residual mass, and teratoma or teratocarcinoma in the primary histology were associated with FDG-PET failure.
authors.affiliation: Department of Oncology, Thomayer University Hospital and First Faculty of Medicine, Charles University, Prague, Czech Republic. tomas.buchler@ftn.cz
authors.forename: Tomas
authors.initials: T
authors.lastname: Buchler
authors.forename: Katerina
authors.initials: K
authors.lastname: Simonova
authors.forename: Pavel
authors.initials: P
authors.lastname: Fencl
authors.forename: Jiri
authors.initials: J
authors.lastname: Jarkovsky
authors.forename: Jitka
authors.initials: J
authors.lastname: Abrahamova
mesh_terms: D000293:Adolescent; D000328:Adult; D018572:Disease-Free Survival; D005188:False Negative Reactions; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008297:Male; D008875:Middle Aged; D018365:Neoplasm, Residual / Q000000981:diagnostic imaging; D009373:Neoplasms, Germ Cell and Embryonal / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000401:mortality; D049268:Positron-Emission Tomography; D011237:Predictive Value of Tests; D013724:Teratoma / Q000175:diagnosis; D013736:Testicular Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000401:mortality; D055815:Young Adult
chemical_list: D019788:Fluorodeoxyglucose F18