title: Is there a link between diabetic glomerular injury and crescent formation? A case report and literature review.
abstract: Glomerular crescents are most commonly associated with rapidly progressive crescentic glomerulonephritis; however, they also develop in response to a wide range of primary and secondary glomerular injuries. Since various kind of glomerulopathies occasionally overlay diabetic glomerular injuries, the presence of crescents in renal biopsy specimens of diabetics may have stimulated a search for etiologies other than diabetes. In this report, we describe an unusual case of diabetic glomerulosclerosis with peculiar extracapillary proliferation. Although such a relationship has so far been ignored in most of the literature, the etiological linkage between diabetic glomerulosclerosis and the development of crescents may not be exceptional. We have reviewed the previous literature and herein discuss the pathological implications of the development of crescents in patients with diabetic glomerulosclerosis.
  The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/3950457896920255.
authors.affiliation: Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-Shi, Tochigi, 329-0498, Japan.
authors.forename: Naoko
authors.initials: N
authors.lastname: Otani
authors.forename: Tetsu
authors.initials: T
authors.lastname: Akimoto
authors.forename: Wako
authors.initials: W
authors.lastname: Yumura
authors.forename: Daisuke
authors.initials: D
authors.lastname: Matsubara
authors.forename: Yoshitaka
authors.initials: Y
authors.lastname: Iwazu
authors.forename: Akihiko
authors.initials: A
authors.lastname: Numata
authors.forename: Takuya
authors.initials: T
authors.lastname: Miki
authors.forename: Fumi
authors.initials: F
authors.lastname: Takemoto
authors.forename: Noriyoshi
authors.initials: N
authors.lastname: Fukushima
authors.forename: Shigeaki
authors.initials: S
authors.lastname: Muto
authors.forename: Eiji
authors.initials: E
authors.lastname: Kusano
mesh_terms: D015415:Biomarkers / Q000097:blood / Q000652:urine; D001706:Biopsy; D049109:Cell Proliferation; D003928:Diabetic Nephropathies / Q000097:blood / Q000188:drug therapy / Q000473:pathology* / Q000652:urine; D006801:Humans; D007150:Immunohistochemistry; D007678:Kidney Glomerulus / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged
chemical_list: D015415:Biomarkers