title: A new depsidone of Lobaria pulmonaria with acetylcholinesterase inhibition activity.
abstract: The phytochemical investigation conducted on a foliose lichen, Lobaria pulmonaria(L.) Hoffm. (Lobariaceae), led to the isolation of a new depsidone in the form of its diacetate derivative which showed a moderate acetylcholinesterase inhibition activity (1 µg) in vitro. This is the first record of identified depsidone structure in searching for these inhibitors.
authors.affiliation: National Research Council of Italy Institute of Biomolecular Chemistry, CNR-ICB, Pozzuoli (Naples), Italy. borispejin@imsi.rs
authors.forename: Boris
authors.initials: B
authors.lastname: Pejin
authors.forename: Giuseppina
authors.initials: G
authors.lastname: Tommonaro
authors.forename: Carmine
authors.initials: C
authors.lastname: Iodice
authors.forename: Vele
authors.initials: V
authors.lastname: Tesevic
authors.forename: Vlatka
authors.initials: V
authors.lastname: Vajs
authors.forename: Salvatore
authors.initials: S
authors.lastname: De Rosa
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D001203:Ascomycota / Q000737:chemistry*; D002800:Cholinesterase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D053630:Depsides / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004789:Enzyme Activation / Q000187:drug effects; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D002800:Cholinesterase Inhibitors; D053630:Depsides; D007783:Lactones; C000875:depsidone; D000110:Acetylcholinesterase