title: Where is the vitamin D receptor?
abstract: The vitamin D receptor (VDR) is a member of the nuclear receptor superfamily and plays a central role in the biological actions of vitamin D. VDR regulates the expression of numerous genes involved in calcium/phosphate homeostasis, cellular proliferation and differentiation, and immune response, largely in a ligand-dependent manner. To understand the global function of the vitamin D system in physiopathological processes, great effort has been devoted to the detection of VDR in various tissues and cells, many of which have been identified as vitamin D targets. This review focuses on the tissue- and cell type-specific distribution of VDR throughout the body.
authors.affiliation: Department of Biochemistry, University of Wisconsin-Madison, 433 Babcock Drive, Madison, WI 53706, USA. yongjiwang@wisc.edu
authors.forename: Yongji
authors.initials: Y
authors.lastname: Wang
authors.forename: Jinge
authors.initials: J
authors.lastname: Zhu
authors.forename: Hector F
authors.initials: HF
authors.lastname: DeLuca
mesh_terms: D000818:Animals; D005786:Gene Expression Regulation; D006801:Humans; D009928:Organ Specificity; D021381:Protein Transport; D018167:Receptors, Calcitriol / Q000235:genetics / Q000378:metabolism*
chemical_list: D018167:Receptors, Calcitriol