title: Effect of endoscopic sinus surgery on pulmonary status of adults with cystic fibrosis.
abstract: OBJECTIVE
  Functional endoscopic sinus surgery (FESS) provides symptomatic relief of sinus disease in patients with cystic fibrosis (CF), but it is unclear whether it has beneficial effects on lung disease in this population. This study assessed the effect of FESS on the respiratory status of adult patients with CF.
  
  
  METHODS
  Retrospective chart review.
  
  
  METHODS
  Tertiary medical center.
  
  
  METHODS
  Thirty-two adult patients with CF who underwent 45 operative cases.
  
  
  METHODS
  Clinical information retrieved for the 12-month periods preceding and following to determine the effect of FESS on the rate of decline in lung function, as well as intravenous antibiotic use and hospitalization for pulmonary exacerbation.
  
  
  RESULTS
  The rate of decline in forced expiratory volume in 1 second and forced vital capacity was not significantly different in the 12 months before and after FESS. Functional endoscopic sinus surgery did not reduce days hospitalized or days on intravenous antibiotics for a respiratory exacerbation in the pre- vs postoperative period. Limiting the analysis to the 30 surgeries that were performed in patients with concomitant respiratory symptoms (ie, excluding the 15 surgeries performed for sinus symptoms alone) did not significantly alter the results. Covariates of importance in CF, including CFTR genotype, gender, or microbiology, did not affect the study results.
  
  
  CONCLUSIONS
  These results did not demonstrate an effect of FESS on progression of lung disease in patients with CF, but further research is needed because low statistical power has made some of the negative findings inconclusive.
authors.affiliation: The Minnesota CF Center, Department of Medicine, University of Minnesota School of Medicine, Minneapolis, Minnesota 55455, USA.
authors.forename: Robert R
authors.initials: RR
authors.lastname: Kempainen
authors.forename: Javad A
authors.initials: JA
authors.lastname: Sajan
authors.forename: Anne M
authors.initials: AM
authors.lastname: Pylkas
authors.forename: Jordan M
authors.initials: JM
authors.lastname: Dunitz
authors.forename: Frank L
authors.initials: FL
authors.lastname: Rimell
authors.forename: Carlos E
authors.initials: CE
authors.lastname: Milla
mesh_terms: D000328:Adult; D003550:Cystic Fibrosis / Q000175:diagnosis / Q000601:surgery*; D004724:Endoscopy; D005260:Female; D005541:Forced Expiratory Volume / Q000502:physiology*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D010256:Paranasal Sinuses / Q000503:physiopathology / Q000601:surgery*; D011183:Postoperative Complications / Q000503:physiopathology*; D013147:Spirometry; D014797:Vital Capacity / Q000502:physiology*; D055815:Young Adult