title: Cytokine receptor activation at the cell surface.
abstract: Cytokines are well recognized for the pleiotropic nature of their signaling and biological activities on many cell types and their role in health and disease. Recent years have seen a steady stream of new cytokine receptor crystal structures including those that are activated by GM-CSF, type I interferon, and a variety of interleukins. Highlights include the observation of a dodecameric signaling complex for the GM-CSF receptor, electron microscopy imaging of an intact gp130/IL-6/IL-6Rα ternary receptor complex bound to its signal transducing Janus kinase and visualization of novel cytokine recognition mechanisms in the interleukin-17 and type I interferon families. This increasing knowledge in cytokine structural biology is driving new opportunities for developing novel therapies to modulate cytokine function in a diverse range of diseases including malignancies and chronic inflammation.
authors.affiliation: St. Vincent's Institute of Medical Research, 9 Princes Street, Fitzroy, Victoria 3065, Australia.
authors.forename: Sophie E
authors.initials: SE
authors.lastname: Broughton
authors.forename: Timothy R
authors.initials: TR
authors.lastname: Hercus
authors.forename: Angel F
authors.initials: AF
authors.lastname: Lopez
authors.forename: Michael W
authors.initials: MW
authors.lastname: Parker
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000737:chemistry* / Q000378:metabolism; D050822:Cytokine Receptor gp130 / Q000737:chemistry / Q000378:metabolism; D016207:Cytokines / Q000737:chemistry / Q000378:metabolism; D006031:Glycosylation; D006801:Humans; D053613:Janus Kinase 1 / Q000737:chemistry / Q000378:metabolism; D008954:Models, Biological; D008958:Models, Molecular; D046912:Multiprotein Complexes / Q000737:chemistry / Q000378:metabolism; D011485:Protein Binding; D011487:Protein Conformation; D055503:Protein Multimerization; D018121:Receptors, Cytokine / Q000737:chemistry* / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D016207:Cytokines; D046912:Multiprotein Complexes; D018121:Receptors, Cytokine; D050822:Cytokine Receptor gp130; D053613:Janus Kinase 1