title: Applying the 2011 St Gallen panel of prognostic markers on a large single hospital cohort of consecutively treated primary operable breast cancers.
abstract: BACKGROUND
  Many easily measurable and readily available factors are now established as being prognostic in primary operable breast cancer. We here applied the 2011 St Gallen surrogate definition for breast cancer subclassification using tumor grade instead of Ki67.
  
  
  METHODS
  Four thousand three hundred and eighteen consecutive patients who had surgery for primary operable breast cancer (1 January 2000 and 31 December 2009) in UZ Leuven excluding primary metastastic male breast cancers and those receiving neoadjuvant therapy. Five different surrogate phenotypes were created using the combined expression of estrogen receptor, progesterone receptor, human epidermal growth factor receptor-2 together with tumor grade. Disease-free interval (DFI), distant metastastis-free interval (DMFI), locoregional relapse-free interval (LRRFI), breast cancer-specific survival (BCSS) and overall survival (OS) were calculated.
  
  
  RESULTS
  Surrogate phenotypes present with significant differences in DFI, DMFI, LRRFI, BCSS and OS. 'Luminal A' tumors presented with the best outcome parameters but the effect weakened at longer follow-up.
  
  
  CONCLUSIONS
  The four surrogate markers, agreed upon by the 2011 St Gallen consensus, defined five prognostic surrogate phenotypes in a large series of consecutively treated breast cancer patients. Their prognostic value changed with longer follow-up. The added value of gene expression profile over classical pathological assessment remains to be defined.
authors.affiliation: Multidisciplinary Breast Centre, University Hospital Leuven, Leuven. Electronic address: olivier.brouckaert@uzleuven.be.
authors.forename: O
authors.initials: O
authors.lastname: Brouckaert
authors.affiliation: Department of Electrical Engineering (ESAT-SISTA), Katholieke Universiteit Leuven, Leuven, Belgium.
authors.forename: A
authors.initials: A
authors.lastname: Laenen
authors.affiliation: Multidisciplinary Breast Centre, University Hospital Leuven, Leuven.
authors.forename: J
authors.initials: J
authors.lastname: Vanderhaegen
authors.affiliation: Multidisciplinary Breast Centre, University Hospital Leuven, Leuven.
authors.forename: H
authors.initials: H
authors.lastname: Wildiers
authors.affiliation: Multidisciplinary Breast Centre, University Hospital Leuven, Leuven.
authors.forename: K
authors.initials: K
authors.lastname: Leunen
authors.affiliation: Multidisciplinary Breast Centre, University Hospital Leuven, Leuven.
authors.forename: F
authors.initials: F
authors.lastname: Amant
authors.affiliation: Multidisciplinary Breast Centre, University Hospital Leuven, Leuven.
authors.forename: P
authors.initials: P
authors.lastname: Berteloot
authors.affiliation: Multidisciplinary Breast Centre, University Hospital Leuven, Leuven.
authors.forename: A
authors.initials: A
authors.lastname: Smeets
authors.affiliation: Multidisciplinary Breast Centre, University Hospital Leuven, Leuven.
authors.forename: R
authors.initials: R
authors.lastname: Paridaens
authors.affiliation: Multidisciplinary Breast Centre, University Hospital Leuven, Leuven.
authors.forename: M R
authors.initials: MR
authors.lastname: Christiaens
authors.affiliation: Multidisciplinary Breast Centre, University Hospital Leuven, Leuven.
authors.forename: G
authors.initials: G
authors.lastname: Floris
authors.affiliation: Multidisciplinary Breast Centre, University Hospital Leuven, Leuven.
authors.forename: P
authors.initials: P
authors.lastname: Moerman
authors.affiliation: Multidisciplinary Breast Centre, University Hospital Leuven, Leuven.
authors.forename: E
authors.initials: E
authors.lastname: Van Limbergen
authors.affiliation: Multidisciplinary Breast Centre, University Hospital Leuven, Leuven.
authors.forename: S
authors.initials: S
authors.lastname: Peeters
authors.affiliation: Multidisciplinary Breast Centre, University Hospital Leuven, Leuven.
authors.forename: C
authors.initials: C
authors.lastname: Weltens
authors.affiliation: Multidisciplinary Breast Centre, University Hospital Leuven, Leuven.
authors.forename: I
authors.initials: I
authors.lastname: Vergote
authors.affiliation: Multidisciplinary Breast Centre, University Hospital Leuven, Leuven.
authors.forename: P
authors.initials: P
authors.lastname: Neven
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000378:metabolism*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D015331:Cohort Studies; D003131:Combined Modality Therapy; D005260:Female; D006760:Hospitalization; D006801:Humans; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D016019:Survival Analysis
chemical_list: D000970:Antineoplastic Agents; D014408:Biomarkers, Tumor