title: Variation in the biomolecular interactions of nickel(II) hydrazone complexes upon tuning the hydrazide fragment.
abstract: Three new bivalent nickel hydrazone complexes have been synthesised from the reactions of [NiCl(2)(PPh(3))(2)] with H(2)L {L = dianion of the hydrazones derived from the condensation of o-hydroxynaphthaldehyde with furoic acid hydrazide (H(2)L(1)) (1)/thiophene-2-acid hydrazide (H(2)L(2)) (2)/isonicotinic acid hydrazide (H(2)L(3)) (3)} and formulated as [Ni(L(1))(PPh(3))] (4), [Ni(L(2))(PPh(3))] (5) and [Ni(L(3))(PPh(3))] (6). Structural characterization of these compounds 4-6 were accomplished by using various physico-chemical techniques. Single crystal X-ray diffraction data of complexes 4 and 5 proved their distorted square planar geometry. In order to ascertain the potential of the above synthesised compounds towards biomolecular interactions, additional experiments involving interaction with calf thymus DNA (CT DNA) and bovine serum albumin (BSA) were carried out. All the ligands and corresponding nickel(ii) chelates have been screened for their scavenging effect towards O(2)(-), OH and NO radicals. The efficiency of complexes 4-6 to arrest the growth of HeLa, HepG-2 and A431 tumour cell lines has been studied along with the cell viability test against the non-cancerous NIH 3T3 cells under in vitro conditions.
authors.affiliation: Department of Chemistry, Bharathiar University, Coimbatore-641 046, India.
authors.forename: Paramasivam
authors.initials: P
authors.lastname: Krishnamoorthy
authors.forename: Palanisamy
authors.initials: P
authors.lastname: Sathyadevi
authors.forename: Rachel R
authors.initials: RR
authors.lastname: Butorac
authors.forename: Alan H
authors.initials: AH
authors.lastname: Cowley
authors.forename: Nattamai S P
authors.initials: NS
authors.lastname: Bhuvanesh
authors.forename: Nallasamy
authors.initials: N
authors.lastname: Dharmaraj
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D001665:Binding Sites; D002417:Cattle; D045744:Cell Line, Tumor; D004247:DNA / Q000378:metabolism; D004996:Ethidium / Q000737:chemistry; D016166:Free Radical Scavengers / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D006571:Heterocyclic Compounds / Q000737:chemistry*; D006801:Humans; D006835:Hydrazones / Q000737:chemistry*; D020128:Inhibitory Concentration 50; D008958:Models, Molecular; D008968:Molecular Conformation; D009532:Nickel / Q000737:chemistry*; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology; D012710:Serum Albumin, Bovine / Q000378:metabolism; D013057:Spectrum Analysis; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D016166:Free Radical Scavengers; D006571:Heterocyclic Compounds; D006835:Hydrazones; D009942:Organometallic Compounds; D012710:Serum Albumin, Bovine; D009532:Nickel; D004247:DNA; D004996:Ethidium