title: Biochemical premotor biomarkers for Parkinson's disease.
abstract: A biomarker is a biological characteristic that is objectively measured and evaluated as an indicator of normal biological or pathologic processes or of pharmacologic responses to a therapeutic intervention. We reviewed the current status of target protein biomarkers (eg, total/oligomeric α-synuclein and DJ-1) in cerebrospinal fluid, as well as on unbiased processes that can be used to discover novel biomarkers. We have also provide details about strategies toward potential populations/models and technologies, including the need for standardized sampling techniques, to pursue the identification of new biochemical markers in the premotor stage of Parkinson's disease in the future.
authors.affiliation: Paracelsus-Elena-Klinik and Georg August University Goettingen, Kassel, Germany. brit.mollenhauer@paracelsus-kliniken.de
authors.forename: Brit
authors.initials: B
authors.lastname: Mollenhauer
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
mesh_terms: D015415:Biomarkers / Q000134:cerebrospinal fluid; D042241:Early Diagnosis; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins / Q000134:cerebrospinal fluid*; D015513:Oncogene Proteins / Q000134:cerebrospinal fluid*; D010300:Parkinson Disease / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000209:etiology; D000071617:Protein Deglycase DJ-1; D051844:alpha-Synuclein / Q000134:cerebrospinal fluid*
chemical_list: D015415:Biomarkers; D047908:Intracellular Signaling Peptides and Proteins; D015513:Oncogene Proteins; D051844:alpha-Synuclein; C105131:PARK7 protein, human; D000071617:Protein Deglycase DJ-1