title: Conglomerated beads shape of lacunar infarcts on diffusion-weighted MRI: what does it suggest?
abstract: OBJECTIVE
  We aimed to analyze lesion patterns of lacunae-sized infarctions in the perforating arterial territory in terms of shape and to determine whether the particular pattern of conglomerated beads shape affected early neurologic deterioration.
  
  
  METHODS
  We consecutively included acute ischemic stroke patients with confirmed lacunae-sized acute ischemic infarcts in the penetrating arterial territories on diffusion-weighted MRI. Based on diffusion-weighted MRI, the shape of ischemic infarcts was divided into oval or conglomerated beads shape. Demographics, risk factors, NIH Stroke Scale (NIHSS) score at admission and discharge, and stroke mechanisms were analyzed. Early neurologic deterioration was defined as any increase of NIHSS score at the time of discharge.
  
  
  RESULTS
  Among 105 patients included, the conglomerated beads shape of infarcts was observed in 34 (32.4%) patients and the oval shape in 71 (67.6%) patients. The baseline characteristics were not different between the 2 groups. However, the maximal diameter of the lesion was significantly larger in the conglomerated beads shape group (12.8 ± 3.3 mm vs 10.8 ± 3.8 mm, p = 0.009). Early neurologic deterioration was also more commonly observed in the conglomerated beads shape group than in the oval shape group (20.6% vs 4.2%, p = 0.012). Multiple logistic regression analysis showed that the conglomerated beads shape was significantly associated with early neurologic deterioration (odds ratio 6.83, 95% confidence interval 1.53-30.55, p = 0.012).
  
  
  CONCLUSIONS
  In 32.4% of all the lacunae-sized infarcts in the perforating artery territory, the conglomerated beads shape was observed. This shape was significantly associated with early neurologic deterioration.
authors.affiliation: Department of Neurology, College of Medicine, The Catholic University of Korea, Yeouido St. Mary’s Hospital, Seoul, South Korea.
authors.forename: Dong Woo
authors.initials: DW
authors.lastname: Ryu
authors.forename: Young-Min
authors.initials: YM
authors.lastname: Shon
authors.forename: Beum Saeng
authors.initials: BS
authors.lastname: Kim
authors.forename: A-Hyun
authors.initials: AH
authors.lastname: Cho
mesh_terms: D000368:Aged; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D018450:Disease Progression; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D002537:Intracranial Arteriosclerosis / Q000175:diagnosis; D020766:Intracranial Embolism / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination; D011379:Prognosis; D059409:Stroke, Lacunar / Q000175:diagnosis*