title: Histopathological classification of pseudomyxoma peritonei and the prognostic importance of PINCH protein.
abstract: OBJECTIVE
  The aims of this study were i) to assess a new and more detailed histopathological classification and to analyze concordance between pathologists in the histopathological classification of pseudomyxoma peritonei (PMP); ii) to analyze the expression in the stroma of the particularly interesting new cysteine-histidine (PINCH) protein and its prognostic importance in PMP.
  
  
  METHODS
  Surgical specimens from 81 patients, classified according to the Ronnett et al histopathological classification were compared to a new system with four groups ranging from indolent to aggressive growth patterns. PINCH protein expression was analyzed and was related to clinical variables.
  
  
  RESULTS
  The new four-group classification provided better prognostic information than the classification according to Ronnett et al. (p=0.04). Expression of the PINCH protein in the stroma was found in 83% of the cases and was associated with high tumor burden (p=0.002) and a poor prognosis (p=0.04).
  
  
  CONCLUSIONS
  The proposed new PMP classification system may provide additional prognostic information. PINCH protein is expressed in PMP and has prognostic information.
authors.affiliation: Department of Surgical Sciences, Section of Surgery, Uppsala University, Uppsala, Sweden.
authors.forename: Håkan
authors.initials: H
authors.lastname: Andréasson
authors.forename: Alkwin
authors.initials: A
authors.lastname: Wanders
authors.forename: Xiao-Feng
authors.initials: XF
authors.lastname: Sun
authors.forename: Roger
authors.initials: R
authors.lastname: Willén
authors.forename: Wilhelm
authors.initials: W
authors.lastname: Graf
authors.forename: Peter
authors.initials: P
authors.lastname: Nygren
authors.forename: Bengt
authors.initials: B
authors.lastname: Glimelius
authors.forename: Zhi-Yong
authors.initials: ZY
authors.lastname: Zhang
authors.forename: Haile
authors.initials: H
authors.lastname: Mahteme
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000502:physiology*; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D060588:LIM Domain Proteins / Q000502:physiology*; D008297:Male; D008565:Membrane Proteins / Q000502:physiology; D008875:Middle Aged; D011379:Prognosis; D011553:Pseudomyxoma Peritonei / Q000378:metabolism*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D060588:LIM Domain Proteins; C088088:LIMS1 protein, human; D008565:Membrane Proteins