title: Prediction of cytogenetic abnormalities with gene expression profiles.
abstract: Cytogenetic abnormalities are important clinical parameters in various types of cancer, including multiple myeloma. We developed a model to predict cytogenetic abnormalities in patients with multiple myeloma using gene expression profiling and validated it by different cytogenetic techniques. The model has an accuracy rate up to 0.89. These results provide proof of concept for the hypothesis that gene expression profiling is a superior genomic method for clinical molecular diagnosis and/or prognosis.
authors.affiliation: Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock, AR 72205, USA.
authors.forename: Yiming
authors.initials: Y
authors.lastname: Zhou
authors.forename: Qing
authors.initials: Q
authors.lastname: Zhang
authors.forename: Owen
authors.initials: O
authors.lastname: Stephens
authors.forename: Christoph J
authors.initials: CJ
authors.lastname: Heuck
authors.forename: Erming
authors.initials: E
authors.lastname: Tian
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Sawyer
authors.forename: Marie-Astrid
authors.initials: MA
authors.lastname: Cartron-Mizeracki
authors.forename: Pingping
authors.initials: P
authors.lastname: Qu
authors.forename: Jason
authors.initials: J
authors.lastname: Keller
authors.forename: Joshua
authors.initials: J
authors.lastname: Epstein
authors.forename: Bart
authors.initials: B
authors.lastname: Barlogie
authors.forename: John D
authors.initials: JD
authors.lastname: Shaughnessy
mesh_terms: D001707:Biopsy, Needle; D001853:Bone Marrow / Q000378:metabolism / Q000473:pathology; D016022:Case-Control Studies; D002869:Chromosome Aberrations; D055028:Comparative Genomic Hybridization; D020732:Cytogenetic Analysis / Q000379:methods*; D005260:Female; D020869:Gene Expression Profiling / Q000379:methods; D006801:Humans; D008297:Male; D046228:Microarray Analysis / Q000379:methods; D015233:Models, Statistical; D009101:Multiple Myeloma / Q000175:diagnosis* / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D011379:Prognosis; D012680:Sensitivity and Specificity