title: Suicidal ideation and thought disorder associated with the formoterol component of combined asthma medication.
abstract: Combination inhaled asthma medications containing corticosteroids and long-acting beta-adrenergic (LABA) agents are generally well tolerated, although a small minority of children receiving them may develop side-effects. Herein is reported a case of a 9-year-old boy who developed insomnia, pressured speech, agitation, and suicidal ideation within the 1st month after initiating formoterol + budesonide. He had not received oral glucocorticoids for >90 days. All symptoms resolved within 48 hr upon discontinuing formoterol while continuing budesonide. To our knowledge, this is the first report of childhood suicidal ideation strongly associated with use of a combination inhaled corticosteroid/LABA.
authors.affiliation: University of Colorado School of Pharmacy, Denver, CO 80206, USA.
authors.forename: Mary Anne
authors.initials: MA
authors.lastname: del Rosario
authors.forename: Bruce G
authors.initials: BG
authors.lastname: Bender
authors.forename: Carl W
authors.initials: CW
authors.lastname: White
mesh_terms: D001249:Asthma / Q000188:drug therapy; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000009:adverse effects*; D019819:Budesonide / Q000008:administration & dosage / Q000009:adverse effects*; D002648:Child; D004359:Drug Therapy, Combination; D004983:Ethanolamines / Q000008:administration & dosage / Q000009:adverse effects*; D000068759:Formoterol Fumarate; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000139:chemically induced*; D059020:Suicidal Ideation; D013850:Thinking / Q000187:drug effects*
chemical_list: D001993:Bronchodilator Agents; D004983:Ethanolamines; D019819:Budesonide; D000068759:Formoterol Fumarate