title: Hijacking mitochondria: bacterial toxins that modulate mitochondrial function.
abstract: Bacterial infection has enormous global social and economic impacts stemming from effects on human health and agriculture. Although there are still many unanswered questions, decades of research has uncovered many of the pathogenic mechanisms at play. It is now clear that bacterial pathogens produce a plethora of proteins known as "toxins" and "effectors" that target a variety of physiological host processes during the course of infection. One of the targets of host targeted bacterial toxins and effectors are the mitochondria. The mitochondrial organelles are major players in many biological functions, including energy conversion to ATP and cell death pathways, which inherently makes them targets for bacterial proteins. We present a summary of the toxins targeted to mitochondria and for those that have been studied in finer detail, we also summarize what we know about the mechanisms of targeting and finally their action at the organelle.
authors.affiliation: Department of Biochemistry & Molecular Biology, Monash University, Clayton, Australia.
authors.forename: Jhih-Hang
authors.initials: JH
authors.lastname: Jiang
authors.forename: Janette
authors.initials: J
authors.lastname: Tong
authors.forename: Kipros
authors.initials: K
authors.lastname: Gabriel
mesh_terms: D000818:Animals; D001424:Bacterial Infections; D001426:Bacterial Proteins / Q000378:metabolism*; D001427:Bacterial Toxins / Q000378:metabolism*; D054884:Host-Pathogen Interactions; D006801:Humans; D053078:Membrane Potential, Mitochondrial; D008928:Mitochondria / Q000378:metabolism / Q000502:physiology*; D021381:Protein Transport
chemical_list: D001426:Bacterial Proteins; D001427:Bacterial Toxins