title: Regulation of polyphosphate kinase production by antisense RNA in Pseudomonas fluorescens Pf0-1.
abstract: Pseudomonas spp. adapt rapidly to environmental fluctuations. Loss or overproduction of polyphosphate reduces the fitness of Pseudomonas fluorescens Pf0-1, indicating the importance of the fine-tuning of polyphosphate production. An antisense RNA was investigated and shown to regulate the polyphosphate kinase gene (ppk) by a posttranscriptional mechanism reducing ppk transcript abundance.
authors.affiliation: Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts, USA. mark.silby@umassd.edu
authors.forename: Mark W
authors.initials: MW
authors.lastname: Silby
authors.forename: Julie S
authors.initials: JS
authors.lastname: Nicoll
authors.forename: Stuart B
authors.initials: SB
authors.lastname: Levy
mesh_terms: D020869:Gene Expression Profiling; D015964:Gene Expression Regulation, Bacterial; D017856:Phosphotransferases (Phosphate Group Acceptor) / Q000096:biosynthesis*; D011122:Polyphosphates / Q000378:metabolism; D011551:Pseudomonas fluorescens / Q000201:enzymology* / Q000235:genetics*; D016372:RNA, Antisense / Q000235:genetics* / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D011122:Polyphosphates; D016372:RNA, Antisense; D017856:Phosphotransferases (Phosphate Group Acceptor); C022424:polyphosphate kinase