title: A novel t(3;8)(p13;q21.1) translocation in a case of lipoblastoma.
abstract: Lipoblastoma is a rare benign neoplasm of embryonic white fatty tissue primarily found in the extremities of children <3 years old (Batanian et al., Cancer Genet Cytogenet 125(1):10-13, 2001; McVay MR et al., J Pediatr Surg 41(6):1067-1071, 2006; Kamal et al., J Pediatr Surg 46(7):E9-E12, 2011). Translocations affecting the 8q11-13 region are commonly reported with lipoblastoma and proper diagnosis requires cytogenetic analysis to distinguish it from malignant myxoid liposarcoma (Miller et al., J Pediatr Surg 32(12):1771-1772, 1997; Morerio et al., Pediatr Blood Cancer 52(1):132-134, 2009). We describe an additional case of lipoblastoma containing a new translocation t(3;8)(p13;q21.1), which has not previously been reported in a healthy asymptomatic child.
authors.affiliation: Section of Pediatric Surgery, Department of Surgery, University of Wisconsin, Madison, WI 53792-7375, USA. abrinkman@uwhealth.org
authors.forename: Adam S
authors.initials: AS
authors.lastname: Brinkman
authors.forename: Bradley
authors.initials: B
authors.lastname: Maxfield
authors.forename: Kara
authors.initials: K
authors.lastname: Gill
authors.forename: Neha J
authors.initials: NJ
authors.lastname: Patel
authors.forename: Ankush
authors.initials: A
authors.lastname: Gosain
mesh_terms: D002675:Child, Preschool; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D020732:Cytogenetic Analysis / Q000379:methods; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D062689:Lipoblastoma / Q000175:diagnosis* / Q000235:genetics* / Q000601:surgery; D008279:Magnetic Resonance Imaging; D013848:Thigh / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed; D014178:Translocation, Genetic / Q000235:genetics*