title: Secoscabronine M, a novel diterpenoid from the Chinese bitter mushroom Sarcodon scabrosus.
abstract: Secoscabronine M (1) is a hemiacetal cyathane diterpenoid that was isolated from the fruiting bodies of the basidiomycete Sarcodon scabrosus (Fr.) Karst. Compound 1 possesses a novel structure with a bond cleavage between C-3 and C-4. The structure of the new compound was elucidated by means of spectroscopic methods, including two-dimensional nuclear magnetic resonance experiments. The absolute configuration of 1 was established by analysis of circular dichroism spectroscopy and also by employing time-dependent density functional theory calculations. In addition, compound 1 was confirmed to be an equilibrium mixture of two epimers (15S and 15R) at position C-15 in polar solvents by one-dimensional nuclear magnetic resonance analysis.
authors.affiliation: College of Science, Northwest A & F University, Yangling, Shaanxi 712100, People's Republic of China.
authors.forename: Xin-Wei
authors.initials: XW
authors.lastname: Shi
authors.forename: An-Ling
authors.initials: AL
authors.lastname: Zhang
authors.forename: Gennaro
authors.initials: G
authors.lastname: Pescitelli
authors.forename: Jin-Ming
authors.initials: JM
authors.lastname: Gao
mesh_terms: D000818:Animals; D001487:Basidiomycota / Q000737:chemistry*; D002942:Circular Dichroism; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D015394:Molecular Structure; D016501:Neurites / Q000187:drug effects; D016716:PC12 Cells; D051381:Rats
chemical_list: D004224:Diterpenes; C497675:cyathane; C576080:secoscabronine M