title: MBT/Pas mouse: a relevant model for the evaluation of Rift Valley fever vaccines.
abstract: Currently, there are no worldwide licensed vaccines for Rift Valley fever (RVF) that are both safe and effective. Development and evaluation of vaccines, diagnostics and treatments depend on the availability of appropriate animal models. Animal models are also necessary to understand the basic pathobiology of infection. Here, we report the use of an inbred MBT/Pas mouse model that consistently reproduces RVF disease and serves our purpose for testing the efficacy of vaccine candidates; an attenuated Rift Valley fever virus (RVFV) and a recombinant RVFV-capripoxvirus. We show that this model is relevant for vaccine testing.
authors.affiliation: Institut Pasteur de Tunis, Université de Tunis El Manar, 1002 Tunis Belvédère, Tunisia.
authors.forename: Emna
authors.initials: E
authors.lastname: Ayari-Fakhfakh
authors.affiliation: Centre National de la Recherche Scientifique, Unité de Recherche Associée 2578, Paris, France.|Mouse Functional Genetics, Institut Pasteur, Paris, France.
authors.forename: Tânia Zaverucha
authors.initials: TZ
authors.lastname: do Valle
authors.affiliation: Centre National de la Recherche Scientifique, Unité de Recherche Associée 2578, Paris, France.|Mouse Functional Genetics, Institut Pasteur, Paris, France.
authors.forename: Laurent
authors.initials: L
authors.lastname: Guillemot
authors.affiliation: Centre National de la Recherche Scientifique, Unité de Recherche Associée 2578, Paris, France.|Mouse Functional Genetics, Institut Pasteur, Paris, France.
authors.forename: Jean-Jacques
authors.initials: JJ
authors.lastname: Panthier
authors.affiliation: Molecular Genetics of Bunyaviruses, Institut Pasteur, Paris, France.
authors.forename: Michèle
authors.initials: M
authors.lastname: Bouloy
authors.affiliation: Institut Pasteur de Tunis, Université de Tunis El Manar, 1002 Tunis Belvédère, Tunisia.
authors.forename: Abdeljelil
authors.initials: A
authors.lastname: Ghram
authors.affiliation: CIRAD, UMR Contrôle des Maladies, Montpellier, F-34398, France.
authors.forename: Emmanuel
authors.initials: E
authors.lastname: Albina
authors.affiliation: CIRAD, UMR Contrôle des Maladies, Montpellier, F-34398, France.
authors.forename: Catherine
authors.initials: C
authors.lastname: Cêtre-Sossah
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D005260:Female; D006801:Humans; D051379:Mice; D012295:Rift Valley Fever / Q000276:immunology* / Q000517:prevention & control*; D012296:Rift Valley fever virus / Q000276:immunology*; D014611:Vaccination / Q000379:methods*; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000276:immunology; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology*
chemical_list: D014613:Vaccines, Attenuated; D014765:Viral Vaccines