title: Radiation Macular Edema after Ru-106 Plaque Brachytherapy for Choroidal Melanoma Resolved by an Intravitreal Dexamethasone 0.7-mg Implant.
abstract: OBJECTIVE
  To report the effective treatment of radiation macular edema following ruthenium-106 plaque brachytherapy for a choroidal melanoma with a dexamethasone 0.7-mg (Ozurdex(®)) intravitreal implant.
  
  
  METHODS
  An interventional case report with optical coherence tomography (OCT) scans.
  
  
  RESULTS
  A 65-year-old Caucasian woman was suffering from radiation macular edema following ruthenium-106 plaque brachytherapy for a choroidal melanoma on her left eye. She had undergone one intravitreal injection of 0.5 mg bevacizumab (Avastin(®), Genentech/Roche) in the following months without functional or anatomical improvement. Seven months after the development of radiation macular edema, she received a single intravitreal injection of dexamethasone 0.7 mg (Ozurdex). Four weeks following the injection, her best-corrected visual acuity improved from 0.3 to 0.5. Radiation macular edema resolved with a reduction of central retinal thickness from 498 μm before Ozurdex injection to 224 μm after Ozurdex injection, as measured by OCT scan.
  
  
  CONCLUSIONS
  Dexamethasone 0.7 mg (Ozurdex) has proven to be an effective treatment option in retinal vein occlusion and noninfectious uveitis. It can also be considered as off-label treatment in radiation macular edema following ruthenium-106 plaque brachytherapy for a choroidal melanoma.
authors.affiliation: Department of Ophthalmology, University of Catania, Catania, Italy.
authors.forename: Andrea
authors.initials: A
authors.lastname: Russo
authors.forename: Teresio
authors.initials: T
authors.lastname: Avitabile
authors.forename: Maurizio
authors.initials: M
authors.lastname: Uva
authors.forename: Salvatore
authors.initials: S
authors.lastname: Faro
authors.forename: Livio
authors.initials: L
authors.lastname: Franco
authors.forename: Marisa
authors.initials: M
authors.lastname: Sanfilippo
authors.forename: Seby
authors.initials: S
authors.lastname: Gulisano
authors.forename: Mario
authors.initials: M
authors.lastname: Toro
authors.forename: Vittorio
authors.initials: V
authors.lastname: De Grande
authors.forename: Stefania
authors.initials: S
authors.lastname: Rametta
authors.forename: Laura
authors.initials: L
authors.lastname: Foti
authors.forename: Antonio
authors.initials: A
authors.lastname: Longo
authors.forename: Michele
authors.initials: M
authors.lastname: Reibaldi