title: Correlation between osteoporosis and degeneration of intervertebral discs in aging rats.
abstract: This study examined the correlation between osteoporosis and the degeneration of intervertebral discs. Sprague-Dawley rats were maintained up to 22 or 28 months. The femoral bone, tibial bone and lumbar vertebra were histologically studied and the expression of collagen type II and X in intervertebral discs was immunohistochemiscally determined. Several indices for the degeneration of intervertebral discs and osteoporosis and the correlation among them were then analyzed. Close correlations were found among the indices for the degeneration of intervertebral discs, including the relative area of the vascular bud, the ratio of the uncalcified and the calcified layers, the expression of collagen type II and X. The correlation with collagen type X was negative. There existed positive correlations among the indices for osteoporosis, including the thickness ratio of cortical bone, the relative area of bone trabecula, the density of femoral and vertebral body bones, and the maximum stress and strain on bone. Analysis on the relationship of osteoporosis and the disease on disc showed that the indices of osteoporosis were negatively correlated with the indices of the degeneration of intervertebral discs but the expression of collagen type X was positively correlated, with the density of vertebral body bones having the strongest dependence on collagen type X. The maximum stress and strain bore no correlation with the degeneration of intervertebral discs. These results suggest that osteoporosis was negatively correlated with the degeneration of intervertebral discs.
authors.affiliation: Department of Orthopedics, First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, 710061, China. zyingang@mail.xjtu.edu.cn.
authors.forename: Yingang
authors.initials: Y
authors.lastname: Zhang
authors.affiliation: Department of Orthopedics, Xi'an Traditional Chinese Medicine Hospital, Xi'an, 710001, China.
authors.forename: Junqing
authors.initials: J
authors.lastname: Xia
authors.affiliation: Department of Orthopedics, First Affiliated Hospital of Medical College of Xi'an Jiaotong University, Xi'an, 710061, China.
authors.forename: Yusheng
authors.initials: Y
authors.lastname: Qiu
authors.affiliation: Department of Cellular and Structural Biology, University of Texas Health Sciences Center, San Antonio, 78229, USA.
authors.forename: Yidong
authors.initials: Y
authors.lastname: Bai
mesh_terms: D000375:Aging / Q000473:pathology*; D000818:Animals; D005260:Female; D055959:Intervertebral Disc Degeneration / Q000209:etiology* / Q000473:pathology* / Q000503:physiopathology; D010024:Osteoporosis / Q000150:complications* / Q000473:pathology* / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013223:Statistics as Topic