title: Solid organ transplantation for non-TTR hereditary amyloidosis: report from the 1st International Workshop on the Hereditary Renal Amyloidoses.
abstract: Fibrinogen A α-chain (AFib) and apolipoprotein AI (AApoAI) amyloidosis due to variants in the AFib and ApoAI genes are the most common types of hereditary amyloidosis in Europe and the United States. Liver is the exclusive source of the aberrant amyloidogenic protein in AFib and responsible for supplying approximately half of the circulating variant ApoAI. Nephrotic syndrome and renal impairment due to renal amyloidosis are common disease manifestations; however, recent research provides evidence to support a more diverse and systemic disease phenotype, which in turn has implications in the management of the hereditary amyloidoses with solid organ transplantation and, in particular, liver transplantation.
authors.affiliation: NHS Amyloidosis Transplant Programme, Liver Unit, Queen Elizabeth Hospital, Birmingham, UK. arie.stangou@nhs.net
authors.forename: Arie J
authors.initials: AJ
authors.lastname: Stangou
authors.forename: Luisa
authors.initials: L
authors.lastname: Lobato
authors.forename: Steven
authors.initials: S
authors.lastname: Zeldenrust
authors.forename: Mohamed
authors.initials: M
authors.lastname: Rela
authors.forename: Bernard
authors.initials: B
authors.lastname: Portmann
authors.forename: Reinhold P
authors.initials: RP
authors.lastname: Linke
authors.forename: Isabel
authors.initials: I
authors.lastname: Conceicao
authors.forename: Gerd
authors.initials: G
authors.lastname: Otto
authors.forename: Henryk
authors.initials: H
authors.lastname: Wilczek
authors.forename: Ole
authors.initials: O
authors.lastname: Suhr
authors.forename: Daniel
authors.initials: D
authors.lastname: Azoulay
authors.forename: Gilles
authors.initials: G
authors.lastname: Grateau
authors.forename: Maria
authors.initials: M
authors.lastname: Picken
authors.forename: John
authors.initials: J
authors.lastname: O'Grady
authors.forename: Nigel
authors.initials: N
authors.lastname: Heaton
authors.forename: Bo-Goran
authors.initials: BG
authors.lastname: Ericzon
authors.forename: Merrill D
authors.initials: MD
authors.lastname: Benson
mesh_terms: D028226:Amyloidosis, Familial / Q000378:metabolism / Q000601:surgery*; D016632:Apolipoprotein A-I / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D016031:Liver Transplantation; D016377:Organ Transplantation; D016896:Treatment Outcome
chemical_list: D016632:Apolipoprotein A-I; C464794:fibrinogen Aalpha; D005340:Fibrinogen