title: Supplementation of milled chia seeds increases plasma ALA and EPA in postmenopausal women.
abstract: Ten postmenopausal women (age 55.6 ± 0.8 years, BMI 24.6 ± 1.1 kg/m²) ingested 25 g/day milled chia seed during a 7-week period, with six plasma samples collected for measurement of α-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), and docosahexaenoic acid (DHA). Subjects operated as their own controls with overnight fasted blood samples taken at baseline (average of two samples), and then after 1, 2, 3, 5, and 7 weeks supplementation. Plasma ALA increased significantly after one week supplementation and was 138 % above baseline levels by the end of the study (overall time effect, P < 0.001). EPA increased 30 % above baseline (overall time effect, P = 0.019) and was correlated across time with ALA (r = 0.84, P = 0.02). No significant change in plasma DPA levels was measured (overall time effect, P = 0.067). Plasma DHA decreased slightly by the end of the study (overall time effect, P = 0.030) and was not correlated with change in ALA. In conclusion, ingestion of 25 g/day milled chia seeds for seven weeks by postmenopausal women resulted in significant increases in plasma ALA and EPA but not DPA and DHA.
authors.affiliation: Human Performance Lab, North Carolina Research Campus, Plants for Human Health Institute, Appalachian State University, 600 Laureate Way, Kannapolis, NC 28081, USA. Fuxia.Jin@dole.com
authors.forename: Fuxia
authors.initials: F
authors.lastname: Jin
authors.forename: David C
authors.initials: DC
authors.lastname: Nieman
authors.forename: Wei
authors.initials: W
authors.lastname: Sha
authors.forename: Guoxiang
authors.initials: G
authors.lastname: Xie
authors.forename: Yunping
authors.initials: Y
authors.lastname: Qiu
authors.forename: Wei
authors.initials: W
authors.lastname: Jia
mesh_terms: D019587:Dietary Supplements; D004281:Docosahexaenoic Acids / Q000097:blood; D015118:Eicosapentaenoic Acid / Q000097:blood*; D005260:Female; D005504:Food Analysis; D005511:Food Handling; D006801:Humans; D008875:Middle Aged; D010936:Plant Extracts / Q000097:blood / Q000494:pharmacology; D017698:Postmenopause / Q000097:blood*; D027544:Salvia / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry*; D017962:alpha-Linolenic Acid / Q000097:blood*
chemical_list: D010936:Plant Extracts; D017962:alpha-Linolenic Acid; D004281:Docosahexaenoic Acids; D015118:Eicosapentaenoic Acid