title: The influence of simvastatin in induced peritoneal fibrosis in rats by peritoneal dialysis solution with glucosis 4.25%.
abstract: OBJECTIVE
  To investigate the influence of using simvastatin on the peritoneal fibrosis induced in rats using peritoneal dialysis solution with glucoses 4.25%.
  
  
  METHODS
  Prospective controlled study in 20 non-uremic Wistar rats. The animals received a peritoneal infusion of 10 ml/100 g of peritoneal dialysis solution glucose 4.25% on a daily basis. The animals were divided in two groups: experimental and control. The experimental group received simvastatin 4 mg/kg/d, by a gastric tube. The control group did not receive any drug. The follow-up was 21 and 49 days. At the end, one surgical procedure was performed to get histological samples of visceral and parietal peritoneum. The samples were analyzed using Hematoxylin Eosin and Sirius Red, to evaluate the severity of the fibrosis.
  
  
  RESULTS
  The analysis showed that the intensity of the fibrosis, the peritoneal thickness and the cell number in experimental and control groups were not statistically significant different in experimental and control groups.
  
  
  CONCLUSIONS
  The simvastatin do not decrease the intensity of fibrosis on the peritoneal membrane that happens on rats on peritoneal dialysis.
authors.affiliation: State University of Ponta Grossa, Curitiba, PR, Brazil.
authors.forename: Gilberto
authors.initials: G
authors.lastname: Baroni
authors.forename: Adriana Fátima Menegat
authors.initials: AF
authors.lastname: Schuinski
authors.forename: Poliana Turmena
authors.initials: PT
authors.lastname: Berticelli
authors.forename: Maria Angélica Alexandre da
authors.initials: MA
authors.lastname: Silva
authors.forename: Denise Sbrissia e Silva
authors.initials: DS
authors.lastname: Gouveia
authors.forename: Roberto
authors.initials: R
authors.lastname: Pecoits Filho
authors.forename: Fernando
authors.initials: F
authors.lastname: Meyer
mesh_terms: D000818:Animals; D002452:Cell Count; D003094:Collagen / Q000032:analysis; D015314:Dialysis Solutions / Q000009:adverse effects*; D005947:Glucose / Q000009:adverse effects*; D008297:Male; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D056627:Peritoneal Fibrosis / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D011446:Prospective Studies; D051381:Rats; D017208:Rats, Wistar; D019821:Simvastatin / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D015314:Dialysis Solutions; D003094:Collagen; D019821:Simvastatin; D005947:Glucose