title: An aptazyme-based molecular device that converts a small-molecule input into an RNA output.
abstract: We describe the construction of an aptazyme-based molecular device that converts, through a cascade of reactions, a small-molecule input into output RNA strands. This device is applicable as an interface between a small molecule and a molecular system that accepts only nucleic acid input.
authors.affiliation: Department of Computational Intelligence and Systems Science, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama, Japan 226-8503.
authors.forename: Shotaro
authors.initials: S
authors.lastname: Ayukawa
authors.forename: Yoko
authors.initials: Y
authors.lastname: Sakai
authors.forename: Daisuke
authors.initials: D
authors.lastname: Kiga
mesh_terms: D052157:Aptamers, Nucleotide / Q000737:chemistry / Q000378:metabolism*; D015374:Biosensing Techniques / Q000379:methods*; D021881:DNA, Catalytic / Q000378:metabolism*; D005486:Flavin Mononucleotide / Q000378:metabolism*; D012313:RNA / Q000032:analysis / Q000378:metabolism*; D016337:RNA, Catalytic / Q000378:metabolism*
chemical_list: D052157:Aptamers, Nucleotide; D021881:DNA, Catalytic; D016337:RNA, Catalytic; D012313:RNA; D005486:Flavin Mononucleotide