title: Decreased aztreonam susceptibility among Pseudomonas aeruginosa isolates from hospital effluent treatment system and clinical samples.
abstract: The aim of this study was to evaluate the antimicrobial resistance patterns of Pseudomonas aeruginosa isolates from hospital wastewater treatment system (HWTS) and clinical specimens in a hospital of Rio de Janeiro city, Brazil. Forty-three isolates obtained from four of the five steps of the HWTS (n = 27) and clinical samples (n = 16) from patients were analyzed regarding their susceptibility profiles to 12 antibiotics. Clinical isolates exhibited higher resistance profiles to antibiotics than wastewater isolates. However, out of 27 isolates from sewage, 62.9% showed decreased susceptibility to aztreonam while 50% of clinical isolates were resistant to this antibiotic. Isolates were not detected at the chlorination stage but they were obtained from the following stage of the treatment revealing the capacity of regrowth after chlorinated sewage effluent. To our knowledge, this is the first study reporting decreased aztreonam susceptibility among P. aeruginosa isolates from a hospital wastewater treatment system. Further investigations are being conducted by our laboratory including a larger sampling program in order to obtain more data.
authors.affiliation: Department of Microbiology, National Institute of Quality Control in Health, Fiocruz, Rio de Janeiro, Brazil.
authors.forename: Deborah O
authors.initials: DO
authors.lastname: Santoro
authors.forename: Célia M C A
authors.initials: CM
authors.lastname: Romão
authors.forename: Maysa M
authors.initials: MM
authors.lastname: Clementino
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001398:Aztreonam / Q000494:pharmacology*; D001938:Brazil; D024881:Drug Resistance, Bacterial; D006761:Hospitals; D006801:Humans; D008826:Microbial Sensitivity Tests; D011552:Pseudomonas Infections / Q000188:drug therapy / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000302:isolation & purification; D014865:Waste Disposal, Fluid; D062065:Wastewater / Q000382:microbiology*; D014873:Water Pollutants / Q000302:isolation & purification
chemical_list: D000900:Anti-Bacterial Agents; D001398:Aztreonam; D062065:Wastewater; D014873:Water Pollutants