title: Radiation pneumonitis following yttrium-90 radioembolization: case report and literature review.
abstract: Radiation-induced pneumonitis (RP) is a rare complication of radioembolization with yttrium-90 ((90)Y) microspheres. The present report describes a case of RP in a patient with liver metastases from a gastrointestinal stromal tumor after radioembolization with (90)Y glass microspheres. This patient developed clinical, functional, and radiographic findings consistent with RP, with near-complete pulmonary parenchymal recovery and no clinical evidence of relapse or progressive decline in pulmonary function over a 9-month period. As clinical use of radioembolization expands, rare adverse events such as RP may become more frequent. It is essential that interventional radiologists, radiation/medical oncologists, and nuclear medicine physicians recognize this potential complication.
authors.affiliation: Department of Radiology, Ohio State University, Columbus, Ohio, USA.
authors.forename: Chadwick L
authors.initials: CL
authors.lastname: Wright
authors.forename: Jeff D
authors.initials: JD
authors.lastname: Werner
authors.forename: Jerry M
authors.initials: JM
authors.lastname: Tran
authors.forename: Vanessa L
authors.initials: VL
authors.lastname: Gates
authors.forename: Ali A
authors.initials: AA
authors.lastname: Rikabi
authors.forename: Manisha H
authors.initials: MH
authors.lastname: Shah
authors.forename: Riad
authors.initials: R
authors.lastname: Salem
mesh_terms: D004621:Embolization, Therapeutic / Q000009:adverse effects*; D046152:Gastrointestinal Stromal Tumors / Q000473:pathology*; D005938:Glucocorticoids / Q000627:therapeutic use; D006499:Hepatic Artery; D006801:Humans; D007580:Jejunal Neoplasms / Q000473:pathology*; D008113:Liver Neoplasms / Q000098:blood supply / Q000532:radiotherapy* / Q000556:secondary*; D008168:Lung / Q000098:blood supply / Q000000981:diagnostic imaging / Q000187:drug effects / Q000528:radiation effects*; D008297:Male; D008875:Middle Aged; D017564:Radiation Pneumonitis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology*; D019275:Radiopharmaceuticals / Q000008:administration & dosage / Q000009:adverse effects*; D011879:Radiotherapy Dosage; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D015021:Yttrium Radioisotopes / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D005938:Glucocorticoids; D019275:Radiopharmaceuticals; D015021:Yttrium Radioisotopes