title: The prevalence and role of human papillomavirus genotypes in primary cervical screening in the northeast of China.
abstract: BACKGROUND
  Studies have shown that type-specific persistence of high-risk human papillomavirus (HPV) infection contributed significantly to cervical carcinogenesis.
  
  
  METHODS
  In this population-based study (on 24041 women), we report on the prevalent genotypes of HPVs and the prevalent genotypes of HPV persistent infection in the northeast of China.
  
  
  RESULTS
  Our results showed that in HPV infected women (45.6% in total), (95% CI, 44.97%-46.23%), 17.35% (95%CI, 16.87%-17.83%) suffered persistent infection. The most common high-risk HPV types in persistent positivity were HPV-16 (18.21%; 95%CI, 17.04%-19.38%), HPV-58 (13.2%; 95%CI, 12.17%-14.23%), HPV-18 (8.66%; 95%CI, 7.81%-9.51%), HPV-52 (7.06%; 95% CI, 6.28%-7.84%) and HPV-33 (6.78%; 95% CI, 6.02%-7.54%). The prevalence of persistent infections with HPV-16,-58, -18, -52 and 33 in cervicitis were lower compared to those in CIN (all P < 0.05). HPV-58, -33 and multiple HPV persistent positivity were significantly associated with older age (all P < 0.05). HPV-18 persistent positivity was significantly associated with adenocarcinoma and lymphatic metastasis (all P < 0.05). HPV-18 persistent positivity was associated with cervical cancer prognosis (P <0.0001). Multivariate analyses showed that HPV-18 persistent positivity, (RR = 1.704, 95%CI = 1.095-2.654, p = 0.028) and lymphatic metastasis (RR = 2.304, 95%CI = 1.354-3.254, P = 0.015) were independent predictors for 3-year survival in cervical cancer.
  
  
  CONCLUSIONS
  we provided extensive results of HPV genotype prevalence and distribution in the northeast of China. HPV genotyping is worthwhile to perform because of its independent prognostic value in cervical cancer.
authors.affiliation: Department of Obstetrics and Gynecology, Shengjing Hospital, China Medical University, Shenyang, Liaoning, China.
authors.forename: Shizhuo
authors.initials: S
authors.lastname: Wang
authors.forename: Heng
authors.initials: H
authors.lastname: Wei
authors.forename: Ning
authors.initials: N
authors.lastname: Wang
authors.forename: Shulan
authors.initials: S
authors.lastname: Zhang
authors.forename: Yao
authors.initials: Y
authors.lastname: Zhang
authors.forename: Qiang
authors.initials: Q
authors.lastname: Ruan
authors.forename: Weiguo
authors.initials: W
authors.lastname: Jiang
authors.forename: Qian
authors.initials: Q
authors.lastname: Xiao
authors.forename: Xiaomei
authors.initials: X
authors.lastname: Luan
authors.forename: Xiuyan
authors.initials: X
authors.lastname: Qian
authors.forename: Lili
authors.initials: L
authors.lastname: Zhang
authors.forename: Xiang
authors.initials: X
authors.lastname: Gao
authors.forename: Xiaowei
authors.initials: X
authors.lastname: Sun
mesh_terms: D002584:Cervix Uteri / Q000473:pathology / Q000821:virology; D002681:China / Q000453:epidemiology; D005260:Female; D005838:Genotype; D006801:Humans; D008403:Mass Screening; D009367:Neoplasm Staging; D009856:Oncogene Proteins, Viral / Q000235:genetics / Q000378:metabolism; D027383:Papillomaviridae / Q000235:genetics*; D015995:Prevalence; D011379:Prognosis; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000473:pathology / Q000821:virology*
chemical_list: C068651:E6 protein, Human papillomavirus type 16; D009856:Oncogene Proteins, Viral; D012097:Repressor Proteins