title: Dynamic material properties of the pregnant human uterus.
abstract: Given that automobile crashes are the largest single cause of death for pregnant females, scientists are developing advanced computer models of pregnant occupants. The purpose of this study is to quantify the dynamic material properties of the human uterus in order to increase the biofidelity of these models. A total of 19 dynamic tension tests were performed on pregnant human uterus tissues taken from six separate donors. The tissues were collected during full term Cesarean style deliveries and tested within 36 h of surgery. The tissues were processed into uniform coupon sections and tested at 1.5 strains/s using linear motors. Local stress and strain were determined from load data and optical markers using high speed video. The experiments resulted in a non-linear stress versus strain curves with an overall average peak failure true strain of 0.32±0.112 and a corresponding peak failure true stress of 656.3±483.9 kPa. These are the first data available for the dynamic response of pregnant human uterus tissues, and it is anticipated they will increase the accuracy of future pregnant female computational models.
authors.affiliation: Virginia Tech-Wake Forest University, School of Biomedical Engineering and Sciences, 313 ICTAS Building, Stanger Street MC 0298, Blacksburg, VA 24061, USA.
authors.forename: Sarah J
authors.initials: SJ
authors.lastname: Manoogian
authors.forename: Jill A
authors.initials: JA
authors.lastname: Bisplinghoff
authors.forename: Andrew R
authors.initials: AR
authors.lastname: Kemper
authors.forename: Stefan M
authors.initials: SM
authors.lastname: Duma
mesh_terms: D005260:Female; D006801:Humans; D011247:Pregnancy / Q000502:physiology*; D013314:Stress, Mechanical; D013718:Tensile Strength; D014599:Uterus / Q000502:physiology*