title: Absolute monocyte/lymphocyte count prognostic score is independent of immunohistochemically determined cell of origin in predicting survival in diffuse large B-cell lymphoma.
abstract: The absolute monocyte/lymphocyte count prognostic score (AMC/ALC score) has not been directly compared with the cell of origin (COO) to predict overall survival (OS) and progression-free survival (PFS) in diffuse large B-cell lymphoma (DLBCL). Thus, we retrospectively examined a new cohort of 99 patients with DLBCL treated from 2008 to 2010, (1) to validate whether AMC/ALC score affects survival, (2) to investigate whether AMC/ALC score is independent of COO to predict survival and (3) to assess whether AMC/ALC score can further stratify clinical outcomes by COO. By univariate analysis, the AMC/ALC score was a predictor for OS and PFS. On multivariate analysis performed including the COO and the International Prognostic Index, AMC/ALC score remained an independent predictor for OS and PFS. The AMC/ALC score was able to further stratify DLBCL clinical outcomes by COO. The AMC/ALC score was independent of COO and added to its ability to identify patients with high-risk disease.
authors.affiliation: Division of Hematology, Mayo Clinic, Rochester, MN, USA. porrata.luis@mayo.edu
authors.forename: Luis F
authors.initials: LF
authors.lastname: Porrata
authors.forename: Kay
authors.initials: K
authors.lastname: Ristow
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Habermann
authors.forename: Nazan
authors.initials: N
authors.lastname: Ozsan
authors.forename: Ahmet
authors.initials: A
authors.lastname: Dogan
authors.forename: William
authors.initials: W
authors.lastname: Macon
authors.forename: Joseph P
authors.initials: JP
authors.lastname: Colgan
authors.forename: Thomas E
authors.initials: TE
authors.lastname: Witzig
authors.forename: David J
authors.initials: DJ
authors.lastname: Inwards
authors.forename: Stephen M
authors.initials: SM
authors.lastname: Ansell
authors.forename: Ivana N
authors.initials: IN
authors.lastname: Micallef
authors.forename: Patrick B
authors.initials: PB
authors.lastname: Johnston
authors.forename: Grzegorz S
authors.initials: GS
authors.lastname: Nowakowski
authors.forename: Carrie
authors.initials: C
authors.lastname: Thompson
authors.forename: Svetomir N
authors.initials: SN
authors.lastname: Markovic
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D018655:Lymphocyte Count; D016403:Lymphoma, Large B-Cell, Diffuse / Q000097:blood* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000502:physiology*; D011379:Prognosis; D016016:Proportional Hazards Models