title: Surgical treatment of gastroesophageal reflux disease.
abstract: BACKGROUND
  Gastroesophageal reflux disease is by far the most prevalent disorder of the foregut. For a long time during the twentieth century, surgical therapy was the mainstay of treatment and the only chance for cure for patients with severe symptoms. Later, after introduction of proton pump inhibitor therapy in the early 1990 s, surgical therapy was considered widely a second choice option due to its potential morbidity and side effects. More recently, however, there is growing evidence that long-term antisecretory therapy might be associated to a number of adverse effects such as osteoporosis and increased risk of cardiovascular events. This is the rationale why interventional and surgical options are coming back into focus.
  
  
  OBJECTIVE
  The purpose of this review is to analyze and to discuss the current spectrum of surgical therapy of gastroesophageal reflux disease.
authors.affiliation: Department of General, Visceral, and Cancer Surgery, University of Cologne, Kerpener Strasse 62, 50931, Cologne, Germany. christian.gutschow@uk-koeln.de
authors.forename: Christian A
authors.initials: CA
authors.lastname: Gutschow
authors.forename: Arnulf H
authors.initials: AH
authors.lastname: Hölscher
mesh_terms: D013505:Digestive System Surgical Procedures / Q000379:methods*; D018662:Fundoplication / Q000379:methods; D005764:Gastroesophageal Reflux / Q000188:drug therapy / Q000601:surgery*; D006801:Humans; D054328:Proton Pump Inhibitors / Q000627:therapeutic use; D013526:Surgical Mesh
chemical_list: D054328:Proton Pump Inhibitors