title: Subacute toxicity of antimicrobial peptide S-thanatin in ICR mice.
abstract: Antibiotics are commonly used for infectious diseases and saved a lot of lives since its discovery, but the emergence of drug-resistant microorganism has brought a tremendous challenge to clinical therapy at present. Antimicrobial peptides, which are of broad antimicrobial spectrum and rare resistance development in pathogens, are expected to replace conventional antibiotics. S-thanatin, a novel antimicrobial peptide with 21 amino acid residues, was proved of significant benefit on therapy of pathogens infection. To evaluate the security of S-thanatin, its subacute toxicity was examined in ICR mice by continually intravenous injection with 125, 50, 20 mg/kg (1/4, 1/10, 1/25 LD(50)) or saline with equal volume for two weeks. Results demonstrated that neither significant difference of serum chemistry and hematology, nor pathological changes were changed in major organs caused by S-thanatin between groups. In conclusion, S-thanatin appears to be a safe antimicrobial peptide for further preclinical trials.
authors.affiliation: Center of Clinical Laboratory Medicine of Zhongda Hospital, Southeast University, Nanjing 210009, China. nationball@163.com
authors.forename: Guoqiu
authors.initials: G
authors.lastname: Wu
authors.forename: Xuepeng
authors.initials: X
authors.lastname: Deng
authors.forename: Pengpeng
authors.initials: P
authors.lastname: Wu
authors.forename: Zilong
authors.initials: Z
authors.lastname: Shen
authors.forename: Hanmei
authors.initials: H
authors.lastname: Xu
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000633:toxicity*; D023181:Antimicrobial Cationic Peptides / Q000633:toxicity*; D001522:Behavior, Animal / Q000187:drug effects; D005260:Female; D006321:Heart / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009206:Myocardium / Q000473:pathology; D013154:Spleen / Q000187:drug effects / Q000473:pathology
chemical_list: D000890:Anti-Infective Agents; D023181:Antimicrobial Cationic Peptides; C098076:thanatin