title: Electrospun TiO2 nanofiber-based cell capture assay for detecting circulating tumor cells from colorectal and gastric cancer patients.
abstract: A nanostructured platform that combines electrospun TiO(2) nanofibers (TiNFs)-deposited substrate and cell-capture agent realizes significant capture of circulating tumor cells (CTCs). The enhanced local topographic interactions between the horizontally packed TiNFs deposited substrates and extracellular matrix scaffolds, in addition to anti-EpCAM/EpCAM biological recognition, contributes to the significantly enhanced capture efficiency compared to flat surfaces.
authors.affiliation: Key Laboratory of Artificial Micro- and Nano-Structures of Ministry of Education, School of Physics and Technology, Wuhan University, Hubei, PR China.
authors.forename: Nangang
authors.initials: N
authors.lastname: Zhang
authors.forename: Yuliang
authors.initials: Y
authors.lastname: Deng
authors.forename: Qidong
authors.initials: Q
authors.lastname: Tai
authors.forename: Boran
authors.initials: B
authors.lastname: Cheng
authors.forename: Libo
authors.initials: L
authors.lastname: Zhao
authors.forename: Qinglin
authors.initials: Q
authors.lastname: Shen
authors.forename: Rongxiang
authors.initials: R
authors.lastname: He
authors.forename: Longye
authors.initials: L
authors.lastname: Hong
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Shishang
authors.initials: S
authors.lastname: Guo
authors.forename: Kan
authors.initials: K
authors.lastname: Liu
authors.forename: Hisan-Rong
authors.initials: HR
authors.lastname: Tseng
authors.forename: Bin
authors.initials: B
authors.lastname: Xiong
authors.forename: Xing-Zhong
authors.initials: XZ
authors.lastname: Zhao
mesh_terms: D000951:Antigens, Neoplasm / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000378:metabolism; D045744:Cell Line, Tumor; D015179:Colorectal Neoplasms / Q000097:blood* / Q000473:pathology; D000071858:Epithelial Cell Adhesion Molecule; D045325:HCT116 Cells; D006367:HeLa Cells; D006801:Humans; D007150:Immunohistochemistry; D020014:K562 Cells; D057139:Nanofibers / Q000737:chemistry*; D009360:Neoplastic Cells, Circulating / Q000378:metabolism; D011205:Povidone / Q000737:chemistry; D013274:Stomach Neoplasms / Q000097:blood* / Q000473:pathology; D014025:Titanium / Q000737:chemistry*
chemical_list: D000951:Antigens, Neoplasm; D015815:Cell Adhesion Molecules; D000071858:Epithelial Cell Adhesion Molecule; C009495:titanium dioxide; D014025:Titanium; D011205:Povidone