title: Are there any significant variations in the clinical or histological presentation of lymphoid pathologies over the course of time in Spain?
abstract: BACKGROUND
  Little data is available concerning variations in the clinical characteristics of lymphoid neoplasms at presentation. We decided to investigate whether any variations in these characteristics had occurred in Spain during the last few years.
  
  
  METHODS
  The GOTEL group database is an archive of all new lymphoma cases, regardless of their histological subtype, diagnosed in the hospitals within the group. An analysis was made of all the records between 1 January 1999 and 1 January 2009. Though the number of hospitals submitting data has changed over the course of time, data were provided by 26 hospitals from 16 Spanish provinces.
  
  
  RESULTS
  A total of 3651 cases of lymphoma were recorded during this period. Grouped by clinical features, 42.8% (1561 patients) had low-grade lymphoma, 30.4% (1110 patients) intermediate-grade lymphoma and 15.2% (556 patients) Hodgkin's lymphoma; 208 patients had T lymphoma (5.7%), 111 patients high-grade lymphoma (3%) and 105 patients (2.9%) suffered lymphomas that were difficult to classify. A total of 6.3% of the diagnoses (231 patients) were made prior to 1999, 29.5% between 2000 and 2001, 25.7% between 2002 and 2003, 19.7% between 2004 and 2005, 11.2% between 2006 and 2007, and there were 200 entries from 2008 to the close of the study period, corresponding to 1.5% of the complete database. The median age at diagnosis was 60 (range 7-105 years), by percentiles: 25 corresponded to 44 years old, 50 to 60 years old and 75 to 71. Distribution by gender was 53.1% male and 46.9% female. An analysis was made of all the clinical variables collected, comparing their behaviour during the different diagnostic periods. The periods, gender, ECOG, stage, LDH, ß2 microglobulin, Hodgkin's or non- Hodgkin's type neoplasm, B lymphoma vs. Hodgkin's, NK or T, nodal or extra-nodal origin, median age at diagnosis and histological type by region of origin did not show any statistically significant differences in their distribution over the course of time.
  
  
  CONCLUSIONS
  In our experience, there are no significant variations in clinical presentation or histological type in lymphomas diagnosed over the course of time in Spain.
authors.affiliation: Servicio de Oncología Médica, Hospital Universitario Puerta de Hierro, Majadahonda, Madrid, Spain. mprovenciop@gmail.es
authors.forename: Mariano
authors.initials: M
authors.lastname: Provencio
authors.forename: Pilar
authors.initials: P
authors.lastname: Sabín
authors.forename: José
authors.initials: J
authors.lastname: Gómez Codina
authors.forename: Antonio
authors.initials: A
authors.lastname: Rueda
authors.forename: Marta
authors.initials: M
authors.lastname: Llanos
authors.forename: Josep
authors.initials: J
authors.lastname: Gumá
authors.forename: Cristina
authors.initials: C
authors.lastname: Quero Blanco
authors.forename: Ana
authors.initials: A
authors.lastname: Blasco
authors.forename: Juan Ramón
authors.initials: JR
authors.lastname: Delgado
authors.forename: Miguel Ángel
authors.initials: MÁ
authors.lastname: Cruz
authors.forename: David
authors.initials: D
authors.lastname: Aguiar
authors.forename: Francisco Ramón
authors.initials: FR
authors.lastname: García-Arroyo
authors.forename: Joaquín
authors.initials: J
authors.lastname: Herrero
authors.forename: Javier
authors.initials: J
authors.lastname: Lavernia
authors.forename: Natividad
authors.initials: N
authors.lastname: Martínez Banaclocha
authors.forename: Manuel
authors.initials: M
authors.lastname: Morales
authors.forename: José
authors.initials: J
authors.lastname: Fuster
authors.forename: Álvaro
authors.initials: Á
authors.lastname: Sáez Cusi
authors.forename: Francisco
authors.initials: F
authors.lastname: Lobo
authors.forename: Delvys
authors.initials: D
authors.lastname: Rodríguez Abreu
authors.forename: Luis
authors.initials: L
authors.lastname: de la Cruz
authors.forename: Edelmira
authors.initials: E
authors.lastname: Antón
authors.forename: Alberto
authors.initials: A
authors.lastname: Rodríguez Jiménez
authors.forename: Alberto
authors.initials: A
authors.lastname: Arízcun
authors.forename: Xavi
authors.initials: X
authors.lastname: Pérez
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008223:Lymphoma / Q000145:classification* / Q000401:mortality / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D011379:Prognosis; D013030:Spain; D015996:Survival Rate; D055815:Young Adult