title: Biological Effect of Leaf Aqueous Extract of Caesalpinia pyramidalis in Goats Naturally Infected with Gastrointestinal Nematodes.
abstract: Forty-eight goats naturally infected with gastrointestinal nematodes were randomly divided into four groups (n = 12): negative control (G1) (untreated), positive control (G2) (treated with doramectin, 1 mL/50 Kg b.w.), and G3 and G4 treated with 2.5 and 5 mg/Kg b.w. of a leaf aqueous extract of Caesalpinia pyramidalis (CP). Fecal and blood samples were regularly collected for the evaluation of fecal egg count (FEC), hematological and immunological parameters to assess the anthelmintic activity. In treated animals with CP, there was noted a significant reduction of 54.6 and 71.2% in the mean FEC (P < 0.05). An increase in IgA levels was observed in G3 and G4 (P < 0.05), during the experimental period, suggesting that it was stimulated by the extract administration. In conclusion, the results showed that CP provoked a protective response in infected animals treated with them. This response could be partly explained by the CP chemical composition.
authors.affiliation: Escola de Medicina Veterinária, Universidade Federal da Bahia, 40170-000 Salvador, BA, Brazil.
authors.forename: Roberto Robson
authors.initials: RR
authors.lastname: Borges-Dos-Santos
authors.forename: Jorge A
authors.initials: JA
authors.lastname: López
authors.forename: Luciano C
authors.initials: LC
authors.lastname: Santos
authors.forename: Farouk
authors.initials: F
authors.lastname: Zacharias
authors.forename: Jorge Maurício
authors.initials: JM
authors.lastname: David
authors.forename: Juceni Pereira
authors.initials: JP
authors.lastname: David
authors.forename: Fernanda Washington de Mendonça
authors.initials: FW
authors.lastname: Lima