title: Key cellular components and interactive histocompatibility molecules regulating tolerance to the fetal allograft.
abstract: Implantation is a major landmark in life. It involves the correct apposition of the embryo in the maternal endometrium. The cellular environment influences placenta development, and direct contact of the fetus with maternal tissues is achieved through decidual cells. At the decidua, and at systemic level, the correct balance of cells potentially acting as antigen-presenting cells and histocompatibility products play a pivotal role in achieving feto-maternal tolerance. Here, we review some of the current issues associated with the interplay between cells and molecules needed for pregnancy development.
authors.affiliation: School of Biological Sciences, University of Essex, Colchester, Essex, UK.
authors.forename: Patrick S
authors.initials: PS
authors.lastname: Spencer
authors.forename: Soukaina M
authors.initials: SM
authors.lastname: Hakam
authors.forename: Phillipe P
authors.initials: PP
authors.lastname: Laissue
authors.forename: Asma
authors.initials: A
authors.lastname: Jabeen
authors.forename: Pallavi
authors.initials: P
authors.lastname: Jain
authors.forename: Soren
authors.initials: S
authors.lastname: Hayrabedyan
authors.forename: Krassimira
authors.initials: K
authors.lastname: Todorova
authors.forename: Alyssa
authors.initials: A
authors.lastname: Blanch
authors.forename: James M W R
authors.initials: JM
authors.lastname: McElhinney
authors.forename: Niwedhie
authors.initials: N
authors.lastname: Muhandiram
authors.forename: Shaza
authors.initials: S
authors.lastname: Alkhatib
authors.forename: Gill B
authors.initials: GB
authors.lastname: Dealtry
authors.forename: Jose M
authors.initials: JM
authors.lastname: Miranda-Sayago
authors.forename: Nelson
authors.initials: N
authors.lastname: Fernández
mesh_terms: D000818:Animals; D010064:Embryo Implantation / Q000276:immunology*; D005260:Female; D047109:Fetal Development / Q000276:immunology; D005333:Fetus / Q000276:immunology; D006680:HLA Antigens / Q000276:immunology; D006648:Histocompatibility; D006801:Humans; D007108:Immune Tolerance; D011247:Pregnancy / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: D006680:HLA Antigens