title: Early impairment of long-term depression in the perirhinal cortex of a mouse model of Alzheimer's disease.
abstract: Visual recognition memory is early impaired in Alzheimer's disease. Long-term depression of synaptic transmission in the perirhinal cortex is critically involved in this form of memory. We found that synaptic transmission was impaired in perirhinal cortex slices obtained from 3-month-old Tg2576 mice, and that 3,000 pulses at 5 Hz induced long-term depression in perirhinal cortex slices from age-matched control mice, but not in those from Tg2576 mice. To our knowledge, these data provide the first evidence of synaptic transmission and long-term depression impairment in the perirhinal cortex in an animal model of Alzheimer's disease, and the earliest synaptic deficit in Tg2576 mice.
authors.affiliation: Department of Human and General Physiology, University of Bologna, Bologna, Italy.
authors.forename: Francesco
authors.initials: F
authors.lastname: Tamagnini
authors.forename: Costanza
authors.initials: C
authors.lastname: Burattini
authors.forename: Tiziana
authors.initials: T
authors.lastname: Casoli
authors.forename: Marta
authors.initials: M
authors.lastname: Balietti
authors.forename: Patrizia
authors.initials: P
authors.lastname: Fattoretti
authors.forename: Giorgio
authors.initials: G
authors.lastname: Aicardi
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics* / Q000503:physiopathology*; D016229:Amyloid beta-Peptides / Q000235:genetics; D000818:Animals; D001931:Brain Mapping / Q000379:methods; D002540:Cerebral Cortex / Q000503:physiopathology*; D004195:Disease Models, Animal; D004594:Electrophysiology / Q000379:methods; D036881:Long-Term Synaptic Depression; D008568:Memory; D051379:Mice; D008822:Mice, Transgenic; D009473:Neuronal Plasticity; D009435:Synaptic Transmission; D013997:Time Factors
chemical_list: D016229:Amyloid beta-Peptides