title: Effects of exercise training on exercise capacity in patients with non-small cell lung cancer receiving targeted therapy.
abstract: OBJECTIVE
  Peak oxygen consumption (VO(2peak)) is an important predictive factor for long-term prognosis in patients with non-small cell lung cancer (NSCLC). The purpose of this study was to investigate whether 8 weeks of exercise training improves exercise capacity, as assessed by VO(2peak), and other related factors in patients with NSCLC receiving targeted therapy.
  
  
  METHODS
  A total of 24 participants with adenocarcinoma were randomly assigned to either the control group (n = 11) or the exercise group (n = 13). Subjects in the exercise group participated in individualized, high-intensity aerobic interval training of exercise. The outcome measures assessed at baseline and after 8 weeks were as follows: VO(2peak) and the percentage of predicted VO(2peak) (%predVO(2peak)), muscle strength and endurance of the right quadriceps, muscle oxygenation during exercise, insulin resistance as calculated by the homeostasis model, high-sensitivity C-reactive protein, and quality of life (QoL) questionnaire inventory.
  
  
  RESULTS
  No exercise-related adverse events were reported. After exercise training, VO(2peak) and %predVO(2peak) increased by 1.6 mL kg(-1) min(-1) and 5.3% (p < 0.005), respectively; these changes were associated with improvements in circulatory, respiratory, and muscular functions at peak exercise (all p = 0.001). The exercise group also had less dyspnea (p = 0.01) and favorably lower fatigue (p = 0.05) than baseline.
  
  
  CONCLUSIONS
  Patients with NSCLC receiving targeted therapy have quite a low exercise capacity, even with a relatively high QoL. Exercise training appears to improve exercise capacity and alleviate some cancer-related symptoms.
authors.affiliation: School and Graduate Institute of Physical Therapy, College of Medicine, National Taiwan University, Floor 3, No.17, Xuzhou Road, Zhongzheng District, Taipei 100, Taiwan.
authors.forename: Chueh-Lung
authors.initials: CL
authors.lastname: Hwang
authors.forename: Chong-Jen
authors.initials: CJ
authors.lastname: Yu
authors.forename: Jin-Yuan
authors.initials: JY
authors.lastname: Shih
authors.forename: Pan-Chyr
authors.initials: PC
authors.lastname: Yang
authors.forename: Ying-Tai
authors.initials: YT
authors.lastname: Wu
mesh_terms: D000230:Adenocarcinoma / Q000150:complications / Q000534:rehabilitation*; D000328:Adult; D000368:Aged; D002097:C-Reactive Protein; D004417:Dyspnea / Q000209:etiology / Q000534:rehabilitation; D005080:Exercise Test; D005081:Exercise Therapy / Q000379:methods*; D017079:Exercise Tolerance; D005221:Fatigue / Q000209:etiology / Q000534:rehabilitation; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008175:Lung Neoplasms / Q000150:complications / Q000534:rehabilitation*; D008297:Male; D008875:Middle Aged; D053580:Muscle Strength; D010101:Oxygen Consumption; D010807:Physical Endurance; D011379:Prognosis; D052097:Quadriceps Muscle; D011788:Quality of Life; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
chemical_list: D002097:C-Reactive Protein