title: Decreased functional brain activation in Friedreich ataxia using the Simon effect task.
abstract: The present study applied the Simon effect task to examine the pattern of functional brain reorganization in individuals with Friedreich ataxia (FRDA), using functional magnetic resonance imaging (fMRI). Thirteen individuals with FRDA and 14 age and sex matched controls participated, and were required to respond to either congruent or incongruent arrow stimuli, presented either to the left or right of a screen, via laterally-located button press responses. Although the Simon effect (incongruent minus congruent stimuli) showed common regions of activation in both groups, including the superior and middle prefrontal cortices, insulae, superior and inferior parietal lobules (LPs, LPi), occipital cortex and cerebellum, there was reduced functional activation across a range of brain regions (cortical, subcortical and cerebellar) in individuals with FRDA. The greater Simon effect behaviourally in individuals with FRDA, compared with controls, together with concomitant reductions in functional brain activation and reduced functional connectivity between cortical and sub-cortical regions, implies a likely disruption of cortico-cerebellar loops and ineffective engagement of cognitive/attention regions required for response suppression.
authors.affiliation: Experimental Neuropsychology Research Unit, School of Psychology and Psychiatry, Monash University, Clayton 3800, Victoria, Australia. nellie.georgiou-karistianis@monash.edu
authors.forename: N
authors.initials: N
authors.lastname: Georgiou-Karistianis
authors.forename: H
authors.initials: H
authors.lastname: Akhlaghi
authors.forename: L A
authors.initials: LA
authors.lastname: Corben
authors.forename: M B
authors.initials: MB
authors.lastname: Delatycki
authors.forename: E
authors.initials: E
authors.lastname: Storey
authors.forename: J L
authors.initials: JL
authors.lastname: Bradshaw
authors.forename: G F
authors.initials: GF
authors.lastname: Egan
mesh_terms: D000328:Adult; D001288:Attention; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D005260:Female; D005621:Friedreich Ataxia / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011597:Psychomotor Performance; D013647:Task Performance and Analysis