title: Paraganglioma of the Organ of Zuckerkandl.
abstract: Paragangliomas are tumors of the sympathetic and parasympathetic paraganglia. While most paraganglioma are of parasympathetic origin and present as benign palpable masses of the neck, sympathetic paraganglioma are often secretory, presenting with symptoms related to excess catecholamines. Such symptoms include hypertension, headache, palpitations, and diaphoresis. Most sympathetic paraganglioma form within the adrenal medulla, the largest sympathetic paraganglia, and are commonly known as pheochromocytomas. However, sympathetic paragangliomas may present extra-adrenally, carrying a significantly higher risk of malignancy. In this manuscript, we examine a case of a young man with an extra-adrenal sympathetic paraganglioma of the Organ of Zuckerkandl. Furthermore, we discuss appropriate diagnostic workup and treatment of pheochromocytomas and sympathetic paragangliomas.
authors.affiliation: Department of Surgery, Tulane University School of Medicine, New Orleans, USA.
authors.forename: Lawrence
authors.initials: L
authors.lastname: Huan
authors.forename: Rachna
authors.initials: R
authors.lastname: Jetly
authors.forename: Emad
authors.initials: E
authors.lastname: Kandil
mesh_terms: D001012:Aorta, Abdominal / Q000000981:diagnostic imaging; D002395:Catecholamines / Q000097:blood / Q000378:metabolism; D004210:Dissection / Q000379:methods; D006801:Humans; D008297:Male; D008991:Monitoring, Physiologic; D010220:Para-Aortic Bodies / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D010235:Paraganglioma / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D011300:Preoperative Care / Q000379:methods; D011379:Prognosis; D011859:Radiography; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D002395:Catecholamines