title: Doped biomolecules in miniaturized electric junctions.
abstract: Control over molecular scale electrical properties within nano junctions is demonstrated, utilizing site-directed C(60) targeting into protein macromolecules as a doping means. The protein molecules, self-assembled in a miniaturized transistor device, yield robust and reproducible operation. Their device signal is dominated by an active center that inverts affinity upon guest incorporation and thus controls the properties of the entire macromolecule. We show how the leading routes of electron transport can be drawn, spatially and energetically, on the molecular level and, in particular, how the dopant effect is dictated by its "strategic" binding site. Our findings propose the extension of microelectronic methodologies to the nanometer scale and further present a promising platform for ex situ studies of biochemical processes.
authors.affiliation: Center for Nanoscience and Nanotechnology, Tel-Aviv University, Israel.
authors.forename: Elad
authors.initials: E
authors.lastname: Mentovich
authors.forename: Bogdan
authors.initials: B
authors.lastname: Belgorodsky
authors.forename: Michael
authors.initials: M
authors.lastname: Gozin
authors.forename: Shachar
authors.initials: S
authors.lastname: Richter
authors.forename: Hagai
authors.initials: H
authors.lastname: Cohen
mesh_terms: D000818:Animals; D002417:Cattle; D004553:Electric Conductivity; D004579:Electron Transport; D037741:Fullerenes / Q000737:chemistry*; D008958:Models, Molecular; D012710:Serum Albumin, Bovine / Q000737:chemistry*; D013499:Surface Properties; D014173:Transistors, Electronic
chemical_list: D037741:Fullerenes; D012710:Serum Albumin, Bovine; C069837:fullerene C60