title: Resveratrol and piperine enhance radiosensitivity of tumor cells.
abstract: The use of ionizing radiation (IR) is essential for treating many human cancers. However, radioresistance markedly impairs the efficacy of tumor radiotherapy. IR enhances the production of reactive oxygen species (ROS) in a variety of cells which are determinant components in the induction of apoptosis. Much interest has developed to augment the effect of radiation in tumors by combining it with radiosensitizers to improve the therapeutic ratio. In the current study, the radiosensitizing effects of resveratrol and piperine on cancer cells were evaluated. Cancer cell lines treated with these natural products exhibited significantly augmented IR-induced apoptosis and loss of mitochondrial membrane potential, presumably through enhanced ROS generation. Applying natural products as sensitizers for IR-induced apoptotic cell death offers a promising therapeutic approach to treat cancer.
authors.affiliation: School of Life Sciences and Biotechnology, College of Natural Sciences, Kyungpook National University, Daegu, Korea.
authors.forename: Jean Kyoung
authors.initials: JK
authors.lastname: Tak
authors.forename: Jun Ho
authors.initials: JH
authors.lastname: Lee
authors.forename: Jeen-Woo
authors.initials: JW
authors.lastname: Park
mesh_terms: D000470:Alkaloids / Q000494:pharmacology*; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects* / Q000528:radiation effects; D052117:Benzodioxoles / Q000494:pharmacology*; D015153:Blotting, Western; D003110:Colonic Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D006801:Humans; D008546:Melanoma, Experimental / Q000188:drug therapy / Q000532:radiotherapy; D053078:Membrane Potential, Mitochondrial / Q000187:drug effects / Q000528:radiation effects; D010084:Oxidation-Reduction; D029222:Piper nigrum / Q000737:chemistry; D010880:Piperidines / Q000494:pharmacology*; D053284:Polyunsaturated Alkamides / Q000494:pharmacology*; D011836:Radiation Tolerance / Q000187:drug effects*; D011839:Radiation, Ionizing; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D017382:Reactive Oxygen Species / Q000378:metabolism; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D000470:Alkaloids; D016588:Anticarcinogenic Agents; D052117:Benzodioxoles; D010880:Piperidines; D053284:Polyunsaturated Alkamides; D011838:Radiation-Sensitizing Agents; D017382:Reactive Oxygen Species; D013267:Stilbenes; D000077185:Resveratrol; C008922:piperine