title: Synthesis and characterization of novel zwitterionic lipids with pH-responsive biophysical properties.
abstract: We report the synthesis and biophysical characterization of a novel class of zwitterionic lipids (ZL) with head groups containing a 3° or 4° amine and carboxylate. ZL form stable liposomes that exhibit head group dependent, pH-responsive biophysical characteristics. These lipids may be suitable components for drug delivery applications due to their ease of synthesis and unique pH-dependent properties.
authors.affiliation: The UC Berkeley-UCSF Graduate Program in Bioengineering, University of California, Berkeley, Berkeley, CA 94720-1762, USA.
authors.forename: Colin L
authors.initials: CL
authors.lastname: Walsh
authors.forename: Juliane
authors.initials: J
authors.lastname: Nguyen
authors.forename: Francis C
authors.initials: FC
authors.lastname: Szoka
mesh_terms: D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry; D002264:Carboxylic Acids / Q000138:chemical synthesis / Q000737:chemistry; D003692:Delayed-Action Preparations / Q000138:chemical synthesis* / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D007477:Ions / Q000138:chemical synthesis* / Q000737:chemistry; D008055:Lipids / Q000138:chemical synthesis* / Q000737:chemistry; D008081:Liposomes / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000588:Amines; D002264:Carboxylic Acids; D003692:Delayed-Action Preparations; D007477:Ions; D008055:Lipids; D008081:Liposomes