title: Fundamental role of microRNAs in androgen-dependent male reproductive biology and prostate cancerogenesis.
abstract: Male reproductive failure has been linked to successive development of various urologic diseases including prostate cancer. There is strong epidemiologic data in support of this association, it is important therefore to identify the fundamental grounds that lay beneath such a connection. Male reproductive biology, as sex determined, is significantly dependent upon the hormonal regulation of androgens. With the advancement of knowledge on androgen receptivity and epigenetic regulation, the role of new regulatory factors such as microRNAs becomes essential. This review focuses on unraveling the role of microRNA tight incorporation in androgen-dependent male reproductive biology in the context of recent prostate cancer data.
authors.affiliation: Institute of Biology and Immunology of Reproduction, BAS, Sofia, Bulgaria. krasiot@abv.bg
authors.forename: Krassimira
authors.initials: K
authors.lastname: Todorova
authors.forename: Milcho
authors.initials: M
authors.lastname: Mincheff
authors.forename: Soren
authors.initials: S
authors.lastname: Hayrabedyan
authors.forename: Jana
authors.initials: J
authors.lastname: Mincheva
authors.forename: Diana
authors.initials: D
authors.lastname: Zasheva
authors.forename: Aleksandar
authors.initials: A
authors.lastname: Kuzmanov
authors.forename: Nelson
authors.initials: N
authors.lastname: Fernández
mesh_terms: D000728:Androgens / Q000378:metabolism*; D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D006801:Humans; D008297:Male; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology*; D012098:Reproduction / Q000235:genetics*
chemical_list: D000728:Androgens; D035683:MicroRNAs