title: [Acute hepatic failure after ingestion of mushrooms].
abstract: This report is about a married couple who were admitted to hospital suffering from gastrointestinal complaints after eating mushrooms. With the suspicion of poisoning with Amanita phalloides treatment started with elimination of the toxins, symptomatic therapy and specific therapy with silibinin. After quantitative determination of the Amanita toxins the patients were immediately transferred to a university hospital.Poisoning by the death cap mushroom is responsible for acute hepatic and often also renal failure and is accompanied by a high mortality. Clinical symptoms follow a three-phase course with gastrointestinal complaints, an asymptomatic interval and finally the hepatorenal phase. Even in suspected cases of intoxication, treatment should be started by antidote therapy with silibinin.
authors.affiliation: Klinik für Kardiologie, Angiologie und Intensivmedizin, Klinikum Lippe-Detmold, Röntgenstrasse 18, Detmold, Germany. ralph.oeckinghaus@klinikum-lippe.de
authors.forename: R
authors.initials: R
authors.lastname: Oeckinghaus
authors.forename: A
authors.initials: A
authors.lastname: Cuneo
authors.forename: J
authors.initials: J
authors.lastname: Brockmeier
authors.forename: G S
authors.initials: GS
authors.lastname: Oeckinghaus
authors.forename: S
authors.initials: S
authors.lastname: Drewek-Platena
authors.forename: St
authors.initials: S
authors.lastname: Hochreuther
authors.forename: J
authors.initials: J
authors.lastname: Götz
authors.forename: U
authors.initials: U
authors.lastname: Tebbe
mesh_terms: D000368:Aged; D000545:Amanita; D000931:Antidotes / Q000627:therapeutic use; D000975:Antioxidants / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D009145:Mushroom Poisoning / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology*; D000077385:Silybin; D012838:Silymarin / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000931:Antidotes; D000975:Antioxidants; D012838:Silymarin; D000077385:Silybin