title: Efficient preparation of incensole and incensole acetate, and quantification of these bioactive diterpenes in Boswellia papyrifera by a RP-DAD-HPLC method.
abstract: Incensole and incensole acetate, found in incense, are encouraging potent bioactive diterpenic cembrenoids, inhibiting Nuclear Factor-kappaB activation. Furthermore, incensole acetate elicits psycho-activity in mice by activating the TRPV3 channels in the brain. Starting from crude extracts of the incense species Boswellia papyrifera Hochst., a convenient procedure for the efficient large-scale synthesis of incensole and its acetate is presented. Additionally, a reversed-phase, diode-array-detection, high-performance liquid chromatography (RP-DAD-HPLC) method for the quantification of incensole and incensole acetate is reported, indicating that these two compounds are typical biomarkers for B. papyrifera.
authors.affiliation: Organic Chemistry II, Am Campus C4.2, Universität des Saarlandes, D-66123 Saarbrücken, Germany.
authors.forename: Michael
authors.initials: M
authors.lastname: Paul
authors.forename: Johann
authors.initials: J
authors.lastname: Jauch
mesh_terms: D000107:Acetylation; D029743:Boswellia / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004224:Diterpenes / Q000138:chemical synthesis / Q000302:isolation & purification*
chemical_list: D004224:Diterpenes; C530368:incensole acetate