title: Zinc oxide nanoparticles catalyzed condensation reaction of isocoumarins and 1,7-heptadiamine in the formation of bis-isoquinolinones.
abstract: The diversified bis-isoquinolinones were obtained in two steps, utilizing homophthalic acid and various acid chlorides providing 3-substituted isocoumarins in the first step which on further condensation with 1,7-heptadiamine involving C-N bond formation from the lactone in the presence of 10 mol% zinc oxide nanoparticles (ZnO NPs) (<150 nm) afforded the desired bis-isoquinolinones in high yield and purity. The synthesized compounds were then characterized using FTIR, (1)H NMR, (13)C NMR, and HRMS techniques.
authors.affiliation: Organic Chemistry Division, School of Advanced Sciences, VIT University, Tamil Nadu, Vellore 632 014, India.
authors.forename: Varadhan
authors.initials: V
authors.lastname: Krishnakumar
authors.forename: Kesarla Mohan
authors.initials: KM
authors.lastname: Kumar
authors.forename: Badal Kumar
authors.initials: BK
authors.lastname: Mandal
authors.forename: Fazlur-Rahman Nawaz
authors.initials: FR
authors.lastname: Khan
mesh_terms: D002384:Catalysis; D003959:Diamines / Q000737:chemistry*; D049934:Isocoumarins / Q000737:chemistry*; D007546:Isoquinolines / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D053768:Metal Nanoparticles; D046529:Microscopy, Electron, Transmission; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction; D015034:Zinc Oxide / Q000737:chemistry*
chemical_list: D003959:Diamines; D049934:Isocoumarins; D007546:Isoquinolines; C015127:1,7-diaminoheptane; D015034:Zinc Oxide