title: Cytogenetic and molecular predictors of outcome in acute lymphocytic leukemia: recent developments.
abstract: During the last decade a tremendous technologic progress based on genome-wide profiling of genetic aberrations, structural DNA alterations, and sequence variations has allowed a better understanding of the molecular basis of pediatric and adult B/T-acute lymphoblastic leukemia (ALL), contributing to a better recognition of the biological heterogeneity of ALL and to a more precise definition of risk factors. Importantly, these advances identified novel potential targets for therapeutic intervention. This review will be focused on the cytogenetic/molecular advances in pediatric and adult ALL based on recently published articles.
authors.affiliation: Department of Hematology and Oncological Sciences L. and A. Seràgnoli, University of Bologna, Bologna, Italy. ilaria.iacobucci2@unibo.it
authors.forename: Ilaria
authors.initials: I
authors.lastname: Iacobucci
authors.forename: Cristina
authors.initials: C
authors.lastname: Papayannidis
authors.forename: Annalisa
authors.initials: A
authors.lastname: Lonetti
authors.forename: Anna
authors.initials: A
authors.lastname: Ferrari
authors.forename: Michele
authors.initials: M
authors.lastname: Baccarani
authors.forename: Giovanni
authors.initials: G
authors.lastname: Martinelli
mesh_terms: D020732:Cytogenetic Analysis / Q000379:methods; D020869:Gene Expression Profiling; D015894:Genome, Human; D006801:Humans; D009154:Mutation; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D017422:Sequence Analysis, DNA / Q000379:methods