title: Risk assessment of amorphous silicon dioxide nanoparticles in a glass cleaner formulation.
abstract: Since nanomaterials are a heterogeneous group of substances used in various applications, risk assessment needs to be done on a case-by-case basis. Here the authors assess the risk (hazard and exposure) of a glass cleaner with synthetic amorphous silicon dioxide (SAS) nanoparticles during production and consumer use (spray application). As the colloidal material used is similar to previously investigated SAS, the hazard profile was considered to be comparable. Overall, SAS has a low toxicity. Worker exposure was analysed to be well controlled. The particle size distribution indicated that the aerosol droplets were in a size range not expected to reach the alveoli. Predictive modelling was used to approximate external exposure concentrations. Consumer and environmental exposure were estimated conservatively and were not of concern. It was concluded based on the available weight-of-evidence that the production and application of the glass cleaner is safe for humans and the environment under intended use conditions.
authors.affiliation: Henkel AG & Co. KGaA, Corporate Scientific Services - Toxicology , Düsseldorf , Germany. karin.michel@henkel.com
authors.forename: Karin
authors.initials: K
authors.lastname: Michel
authors.forename: Julia
authors.initials: J
authors.lastname: Scheel
authors.forename: Stefan
authors.initials: S
authors.lastname: Karsten
authors.forename: Norbert
authors.initials: N
authors.lastname: Stelter
authors.forename: Thorsten
authors.initials: T
authors.lastname: Wind
mesh_terms: D000818:Animals; D055598:Chemical Phenomena; D003902:Detergents / Q000737:chemistry*; D006801:Humans; D019570:Inhalation Exposure / Q000032:analysis*; D008956:Models, Chemical; D053758:Nanoparticles / Q000737:chemistry*; D018570:Risk Assessment / Q000379:methods; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D003902:Detergents; D012822:Silicon Dioxide