title: Changes in skin mechanical properties after long-term application of cream containing green tea extract.
abstract: OBJECTIVE
  We studied longterm application of cream containing green tea extract, to obtain knowledge of its effects on epidermal mechanics by 2-mm diameter Cutometer probe.
  
  
  METHODS
  Using this non-invasive device, we assessed the effects of green tea extract cream on skin mechanical properties. Healthy male volunteers (n=10) were included in this study, which lasted 60 days. The biomechanical properties of the skin were examined by a non-invasive suction device (Cutometer) and the cheeks were defined as the test area.
  
  
  RESULTS
  Statistically significant (p<0.05) results were notable for the R6 (Uv/Ue) parameter with respect to time (ANOVA); R0, R2 (Ua/Uf) and R7 (Ur/Uf) parameters were found statistically not significant by ANOVA. This study demonstrates that green tea formulation has a certain effect on R6 (Uv/Ue) parameter when applied regularly for a certain period of time.
  
  
  CONCLUSIONS
  These results indicate that the formulation has no pronounced overall effects on skin elastic or biological properties, but significant R6 (Uv/Ue) values indicate that it does have definite effects on the viscoelastic properties of the skin.
authors.affiliation: Department of Pharmacy, Faculty of Pharmacy and Alternative Medicine, The Islamia University of Bahawalpur, Pakistan. redgrape.u@gmail.com
authors.forename: Tariq
authors.initials: T
authors.lastname: Mahmood
authors.forename: Naveed
authors.initials: N
authors.lastname: Akhtar
authors.forename: Barkat Ali
authors.initials: BA
authors.lastname: Khan
authors.forename: Haji M
authors.initials: HM
authors.lastname: Shoaib Khan
authors.forename: Tariq
authors.initials: T
authors.lastname: Saeed
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000704:Analysis of Variance; D000975:Antioxidants / Q000008:administration & dosage; D001688:Biological Products / Q000008:administration & dosage; D028241:Camellia sinensis / Q000737:chemistry*; D002392:Catechin / Q000008:administration & dosage / Q000737:chemistry; D004548:Elasticity / Q000187:drug effects*; D004643:Emollients / Q000008:administration & dosage; D006801:Humans; D008297:Male; D010936:Plant Extracts / Q000008:administration & dosage*; D016037:Single-Blind Method; D012867:Skin / Q000033:anatomy & histology / Q000187:drug effects*; D016896:Treatment Outcome
chemical_list: D000975:Antioxidants; D001688:Biological Products; D004643:Emollients; D010936:Plant Extracts; D002392:Catechin