title: Chiral phosphoric acid-catalyzed enantioselective and diastereoselective spiroketalizations.
abstract: Catalytic enantioselective and diastereoselective spiroketalizations with BINOL-derived chiral phosphoric acids are reported. The chiral catalyst can override the inherent preference for the formation of thermodynamic spiroketals, and highly selective formation of nonthermodynamic spiroketals could be achieved under the reaction conditions.
authors.affiliation: Chemistry Department, University of Michigan, Ann Arbor, Michigan 48109, United States.
authors.forename: Zhankui
authors.initials: Z
authors.lastname: Sun
authors.forename: Grace A
authors.initials: GA
authors.lastname: Winschel
authors.forename: Alina
authors.initials: A
authors.lastname: Borovika
authors.forename: Pavel
authors.initials: P
authors.lastname: Nagorny
mesh_terms: D002384:Catalysis; D005663:Furans / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D010756:Phosphoric Acids / Q000737:chemistry*; D013141:Spiro Compounds / Q000737:chemistry*; D013237:Stereoisomerism; D013379:Substrate Specificity
chemical_list: D005663:Furans; D010756:Phosphoric Acids; D013141:Spiro Compounds; C520774:spiroketal; C030242:phosphoric acid