title: Increased expression of BAG-1 in rat brain cortex after traumatic brain injury.
abstract: BAG-1 protein was initially identified as a Bcl-2-binding protein. It was reported to enhance Bcl-2 protection from cell death, suggesting that BAG-1 represents a new type of anti-cell death gene. Moreover, recent study has shown that BAG-1 can enhance the proliferation of neuronal precursor cells, attenuate the growth inhibition induced by siah1. However, its function and expression in the central nervous system lesion are not been understood very well. In this study, we performed a traumatic brain injury (TBI) model in adult rats and investigated the dynamic changes of BAG-1 expression in the brain cortex. Double immunofluorescence staining revealed that BAG-1 was co-expressed with NEURON and glial fibrillary acidic protein (GFAP). In addition, we detected that proliferating cell nuclear antigen had the co-localization with GFAP, and BAG-1. All our findings suggested that BAG-1 might involve in the pathophysiology of brain after TBI.
authors.affiliation: The Jiangsu Province Key Laboratory of Neuroregeneration, Nantong University, Nantong 226001, Peoples Republic of China.
authors.forename: Ting
authors.initials: T
authors.lastname: Xu
authors.forename: Xueqian
authors.initials: X
authors.lastname: Wang
authors.forename: Maohong
authors.initials: M
authors.lastname: Cao
authors.forename: Xinmin
authors.initials: X
authors.lastname: Wu
authors.forename: Yaohua
authors.initials: Y
authors.lastname: Yan
authors.forename: Hongran
authors.initials: H
authors.lastname: Fu
authors.forename: Wei
authors.initials: W
authors.lastname: Zhao
authors.forename: Peipei
authors.initials: P
authors.lastname: Gong
authors.forename: Kaifu
authors.initials: K
authors.lastname: Ke
authors.forename: Xingxing
authors.initials: X
authors.lastname: Gu
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000378:metabolism* / Q000473:pathology; D001930:Brain Injuries / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D049109:Cell Proliferation; D002540:Cerebral Cortex / Q000293:injuries / Q000378:metabolism* / Q000473:pathology; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D015870:Gene Expression; D005904:Glial Fibrillary Acidic Protein / Q000235:genetics / Q000378:metabolism; D007150:Immunohistochemistry; D008297:Male; D009474:Neurons / Q000378:metabolism* / Q000473:pathology; D018809:Proliferating Cell Nuclear Antigen / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism; D015854:Up-Regulation
chemical_list: C091732:BCL2-associated athanogene 1 protein; D004268:DNA-Binding Proteins; D005904:Glial Fibrillary Acidic Protein; D018809:Proliferating Cell Nuclear Antigen; D014157:Transcription Factors