title: Identification of a key prenyltransferase involved in biosynthesis of the most abundant fungal meroterpenoids derived from 3,5-dimethylorsellinic acid.
abstract: Destroying aromaticity: A novel prenyltransferase (Trt2) involved in fungal meroterpenoid biosynthesis was shown to catalyze an unusual aromatic addition reaction onto a fully substituted aromatic ring. The prenylated product serves as a key intermediate in the biosynthesis of the most abundant series of meroterpenoids in fungi.
authors.affiliation: Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
authors.forename: Takayuki
authors.initials: T
authors.lastname: Itoh
authors.forename: Kinya
authors.initials: K
authors.lastname: Tokunaga
authors.forename: Edayileveettil K
authors.initials: EK
authors.lastname: Radhakrishnan
authors.forename: Isao
authors.initials: I
authors.lastname: Fujii
authors.forename: Ikuro
authors.initials: I
authors.lastname: Abe
authors.forename: Yutaka
authors.initials: Y
authors.lastname: Ebizuka
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Kushiro
mesh_terms: D004122:Dimethylallyltranstransferase / Q000737:chemistry / Q000378:metabolism*; D005656:Fungal Proteins / Q000737:chemistry / Q000378:metabolism*; D005658:Fungi / Q000201:enzymology* / Q000378:metabolism; D012118:Resorcinols / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013729:Terpenes / Q000378:metabolism*
chemical_list: D005656:Fungal Proteins; D012118:Resorcinols; D013729:Terpenes; C501612:orsellinic acid; D004122:Dimethylallyltranstransferase