title: Impact of cytomegalovirus on early immunosenescence of CD8+ T lymphocytes after solid organ transplantation.
abstract: The increasing number of elderly people eligible for solid organ transplants has made it necessary to reevaluate how the decline in immune function associated to ageing (immunosenescence) affects solid organ transplants. Some immunosenescence biomarkers, such as the expansion of CD28(-)CD8+ T lymphocytes, have been associated to cytomegalovirus infection and are related to a form of accelerated immune senescence in transplant recipients. However, the impact of cytomegalovirus replication on downregulation of CD28 on total CD8+ T cells is independent of patients' age, whereas downregulation on cytomegalovirus-specific CD8+ T cells depends on patients' age, inducing early immunosenescence of cytomegalovirus-specific CD8+ T cells in young but not elderly solid organ transplants recipients. Although immunosenescence in transplant recipients should be considered a two-edged sword as it is a risk factor for the development of tumors after transplantation, it has a beneficial effect in attenuating acute allograft rejection and correlates with better clinical outcomes.
authors.affiliation: BSc, Instituto Maimónides de Investigación Biomédica de Córdoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, Cordoba, Spain. sacanti@hotmail.com
authors.forename: Sara
authors.initials: S
authors.lastname: Cantisán
authors.forename: Julián
authors.initials: J
authors.lastname: Torre-Cisneros
authors.forename: Rosario
authors.initials: R
authors.lastname: Lara
authors.forename: Sofía
authors.initials: S
authors.lastname: Zarraga
authors.forename: Miguel
authors.initials: M
authors.lastname: Montejo
authors.forename: Rafael
authors.initials: R
authors.lastname: Solana
mesh_terms: D000368:Aged; D000375:Aging / Q000276:immunology* / Q000473:pathology; D018106:CD28 Antigens / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000473:pathology; D016922:Cellular Senescence / Q000276:immunology; D003587:Cytomegalovirus / Q000276:immunology / Q000472:pathogenicity* / Q000502:physiology; D003586:Cytomegalovirus Infections / Q000209:etiology / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D018448:Models, Immunological; D009369:Neoplasms / Q000209:etiology / Q000276:immunology; D012307:Risk Factors; D014181:Transplantation Immunology; D019737:Transplants / Q000009:adverse effects*; D014779:Virus Replication
chemical_list: D018106:CD28 Antigens