title: Molecular mechanisms linking endometriosis under oxidative stress with ovarian tumorigenesis and therapeutic modalities.
abstract: Inflammation plays a role in the pathogenesis of endometriosis. Endometriosis-associated ovarian carcinogenesis might be promoted through oxidative stress-induced increased genomic instability, aberrant methylation, and aberrant chromatin remodeling, as well as mutations of tumor suppressor genes. Aberrant expression of ARID1A, PIK3CA, and NF-kB genes has been recognized as the major target genes involved in oxidative stress-induced carcinogenesis. HNF-1beta appears to play a key role in anti-oxidative defense mechanisms. We discuss the pathophysiologic roles of oxidative stress as somatic mutations as well as highly specific agents that effectively modulate these targets.
authors.affiliation: Department of Obstetrics and Gynecology, Nara Medical University,   Nara,   Japan.
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Shigetomi
authors.forename: Taihei
authors.initials: T
authors.lastname: Tsunemi
authors.forename: Shoji
authors.initials: S
authors.lastname: Haruta
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Kajihara
authors.forename: Yoriko
authors.initials: Y
authors.lastname: Yoshizawa
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Tanase
authors.forename: Naoto
authors.initials: N
authors.lastname: Furukawa
authors.forename: Shozo
authors.initials: S
authors.lastname: Yoshida
authors.forename: Toshiyuki
authors.initials: T
authors.lastname: Sado
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Kobayashi
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000188:drug therapy / Q000378:metabolism; D000975:Antioxidants / Q000627:therapeutic use; D004715:Endometriosis / Q000150:complications* / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007249:Inflammation / Q000473:pathology; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000209:etiology / Q000378:metabolism*; D018384:Oxidative Stress / Q000187:drug effects / Q000235:genetics; D015398:Signal Transduction
chemical_list: D000975:Antioxidants