title: No increased mortality from donor or recipient hepatitis B- and/or hepatitis C-positive serostatus after related-donor allogeneic hematopoietic cell transplantation.
abstract: Limited data exist on allogeneic transplant outcomes in recipients receiving hematopoietic cells from donors with prior or current hepatitis B (HBV) or C virus (HCV) infection (seropositive donors), or for recipients with prior or current HBV or HCV infection (seropositive recipients). Transplant outcomes are reported for 416 recipients from 121 centers, who received a human leukocyte antigen-identical related-donor allogeneic transplant for hematologic malignancies between 1995 and 2003. Of these, 33 seronegative recipients received grafts from seropositive donors and 128 recipients were seropositive. The remaining 256 patients served as controls. With comparable median follow-up (cases, 5.9 years; controls, 6.7 years), the incidence of treatment-related mortality, survival, graft-versus-host disease, and hepatic toxicity, appears similar in all cohorts. The frequencies of hepatic toxicities as well as causes of death between cases and controls were similar. Prior exposure to HBV or HCV in either the donor or the recipient should not be considered an absolute contraindication to transplant.
authors.affiliation: Blood and Marrow Transplantation, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, USA. marcie.tomblyn@moffitt.org
authors.forename: M
authors.initials: M
authors.lastname: Tomblyn
authors.forename: M
authors.initials: M
authors.lastname: Chen
authors.forename: M
authors.initials: M
authors.lastname: Kukreja
authors.forename: M D
authors.initials: MD
authors.lastname: Aljurf
authors.forename: F
authors.initials: F
authors.lastname: Al Mohareb
authors.forename: B J
authors.initials: BJ
authors.lastname: Bolwell
authors.forename: J-Y
authors.initials: JY
authors.lastname: Cahn
authors.forename: M H
authors.initials: MH
authors.lastname: Carabasi
authors.forename: R P
authors.initials: RP
authors.lastname: Gale
authors.forename: R E
authors.initials: RE
authors.lastname: Gress
authors.forename: V
authors.initials: V
authors.lastname: Gupta
authors.forename: G A
authors.initials: GA
authors.lastname: Hale
authors.forename: P
authors.initials: P
authors.lastname: Ljungman
authors.forename: R T
authors.initials: RT
authors.lastname: Maziarz
authors.forename: J
authors.initials: J
authors.lastname: Storek
authors.forename: J R
authors.initials: JR
authors.lastname: Wingard
authors.forename: J-A H
authors.initials: JA
authors.lastname: Young
authors.forename: M M
authors.initials: MM
authors.lastname: Horowitz
authors.forename: K K
authors.initials: KK
authors.lastname: Ballen
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation / Q000401:mortality*; D016174:Hepacivirus; D006509:Hepatitis B / Q000453:epidemiology / Q000401:mortality* / Q000821:virology; D006515:Hepatitis B virus; D006526:Hepatitis C / Q000453:epidemiology / Q000401:mortality* / Q000821:virology; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D008875:Middle Aged; D014019:Tissue Donors; D014180:Transplantation; D014184:Transplantation, Homologous / Q000401:mortality*; D055815:Young Adult