title: Mobilization of CD34+CXCR4+ stem/progenitor cells and the parameters of left ventricular function and remodeling in 1-year follow-up of patients with acute myocardial infarction.
abstract: Mobilization of stem cells in acute MI might signify the reparatory response. Aim of the Study. Prospective evaluation of correlation between CD34+CXCR4+ cell mobilization and improvement of LVEF and remodeling in patients with acute MI in 1-year followup. Methods. 50 patients with MI, 28 with stable angina (SAP), and 20 individuals with no CAD (CTRL). CD34+CXCR4+ cells, SDF-1, G-CSF, troponin I (TnI) and NT-proBNP were measured on admission and 1 year after MI. Echocardiography and ergospirometry were carried out after 1 year. Results. Number of CD34+CXCR4+ cells in acute MI was significantly higher in comparison with SAP and CTRL, but lower in patients with decreased LVEF ≤40%. In patients who had significant LVEF increase ≥5% in 1 year FU the number of cells in acute MI was significantly higher versus patients with no LVEF improvement. Number of cells was positively correlated (r = 0,41, P = 0,031) with absolute LVEF change and inversely with absolute change of ESD and EDD in 1-year FU. Mobilization of CD34+CXCR4+ cells in acute MI was negatively correlated with maximum TnI and NT-proBNP levels. Conclusion. Mobilization of CD34+CXCR4+ cells in acute MI shows significant positive correlation with improvement of LVEF after 1 year.
authors.affiliation: Third Division of Cardiology, Medical University of Silesia, 45-47 Ziołowa Street, 40-635 Katowice, Poland.
authors.forename: Rafał
authors.initials: R
authors.lastname: Wyderka
authors.forename: Wojciech
authors.initials: W
authors.lastname: Wojakowski
authors.forename: Tomasz
authors.initials: T
authors.lastname: Jadczyk
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Maślankiewicz
authors.forename: Zofia
authors.initials: Z
authors.lastname: Parma
authors.forename: Tomasz
authors.initials: T
authors.lastname: Pawłowski
authors.forename: Piotr
authors.initials: P
authors.lastname: Musiałek
authors.forename: Marcin
authors.initials: M
authors.lastname: Majka
authors.forename: Marek
authors.initials: M
authors.lastname: Król
authors.forename: Wacław
authors.initials: W
authors.lastname: Kuczmik
authors.forename: Sebastian
authors.initials: S
authors.lastname: Dworowy
authors.forename: Barbara
authors.initials: B
authors.lastname: Korzeniowska
authors.forename: Mariusz Z
authors.initials: MZ
authors.lastname: Ratajczak
authors.forename: Michał
authors.initials: M
authors.lastname: Tendera
mesh_terms: D000368:Aged; D018952:Antigens, CD34 / Q000096:biosynthesis*; D054377:Chemokine CXCL12 / Q000096:biosynthesis; D004452:Echocardiography / Q000379:methods; D005260:Female; D005500:Follow-Up Studies; D016179:Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis; D019650:Hematopoietic Stem Cell Mobilization; D006801:Humans; D007249:Inflammation; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000378:metabolism*; D020097:Natriuretic Peptide, Brain / Q000096:biosynthesis; D010446:Peptide Fragments / Q000096:biosynthesis; D011379:Prognosis; D019718:Receptors, CXCR4 / Q000096:biosynthesis*; D013234:Stem Cells / Q000166:cytology*; D013997:Time Factors; D019210:Troponin I / Q000096:biosynthesis; D016277:Ventricular Function, Left / Q000502:physiology*; D020257:Ventricular Remodeling
chemical_list: D018952:Antigens, CD34; C515255:CXCL12 protein, human; C527276:CXCR4 protein, human; D054377:Chemokine CXCL12; D010446:Peptide Fragments; D019718:Receptors, CXCR4; D019210:Troponin I; C109794:pro-brain natriuretic peptide (1-76); D020097:Natriuretic Peptide, Brain; D016179:Granulocyte Colony-Stimulating Factor