title: [Correction of endothelial dysfunction by L-arginine under experimental pre-eclampsia conditions].
abstract: The ADMA-like pre-eclampsia in pregnant rats was modeled by daily introduction of L-NAME in a dose of 25 mg/kg for 7 days. L-arginine (200 mg/kg) prevented the development of arterial hypertension and a decrease in placentary microcirculation and microalbuminuria. The possibility of using L-arginine for the prevention of competitive eNOS inhibition by ADMA is discussed.
authors.forename: M V
authors.initials: MV
authors.lastname: Pokrovskiĭ
authors.forename: T G
authors.initials: TG
authors.lastname: Pokrovskaia
authors.forename: V V
authors.initials: VV
authors.lastname: Gureev
authors.forename: A A
authors.initials: AA
authors.lastname: Barsuk
authors.forename: E V
authors.initials: EV
authors.lastname: Proskuriakova
authors.forename: M V
authors.initials: MV
authors.lastname: Korokin
authors.forename: O S
authors.initials: OS
authors.lastname: Gudyrev
authors.forename: A S
authors.initials: AS
authors.lastname: Belous
authors.forename: V I
authors.initials: VI
authors.lastname: Kochkarov
authors.forename: L M
authors.initials: LM
authors.lastname: Danilenko
authors.forename: O V
authors.initials: OV
authors.lastname: Levashova
authors.forename: N V
authors.initials: NV
authors.lastname: Mal'tseva
authors.forename: O S
authors.initials: OS
authors.lastname: Polianskaia
mesh_terms: D000419:Albuminuria / Q000517:prevention & control; D000818:Animals; D001120:Arginine / Q000008:administration & dosage* / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D004727:Endothelium / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006801:Humans; D006973:Hypertension / Q000517:prevention & control*; D007274:Injections, Intraperitoneal; D008833:Microcirculation / Q000187:drug effects / Q000502:physiology; D019331:NG-Nitroarginine Methyl Ester / Q000008:administration & dosage / Q000009:adverse effects; D052250:Nitric Oxide Synthase Type III / Q000378:metabolism; D010920:Placenta / Q000098:blood supply / Q000187:drug effects*; D011225:Pre-Eclampsia / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D011247:Pregnancy; D051381:Rats
chemical_list: D001120:Arginine; D052250:Nitric Oxide Synthase Type III; C496316:Nos3 protein, rat; D019331:NG-Nitroarginine Methyl Ester