title: Ianthellamide A, a selective kynurenine-3-hydroxylase inhibitor from the Australian marine sponge Ianthella quadrangulata.
abstract: Ianthellamide A (1), a novel octopamine derivative, was isolated from the Australian marine sponge Ianthella quadrangulata. Compound 1 selectively inhibited the activity of kynurenine 3-hydroxylase with an IC(50) value of 1.5 μM. It also significantly increased the level of endogenous kynurenic acid in rat brain and hence has the potential as a neuroprotective agent in the treatment of neurodegenerative disorders.
authors.affiliation: Eskitis Institute, Griffith University, Brisbane, QLD 4111, Australia. y.feng@griffith.edu.au
authors.forename: Yunjiang
authors.initials: Y
authors.lastname: Feng
authors.forename: Bruce F
authors.initials: BF
authors.lastname: Bowden
authors.forename: Vimal
authors.initials: V
authors.lastname: Kapoor
mesh_terms: D000818:Animals; D001557:Benzenesulfonates / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D050601:Kynurenine 3-Monooxygenase / Q000037:antagonists & inhibitors*; D009682:Magnetic Resonance Spectroscopy; D008386:Marine Biology; D009655:Octopamine / Q000031:analogs & derivatives* / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*
chemical_list: D001557:Benzenesulfonates; D004791:Enzyme Inhibitors; C574805:lanthellamide A; D009655:Octopamine; D050601:Kynurenine 3-Monooxygenase