title: The CPEB-family of proteins, translational control in senescence and cancer.
abstract: Cytoplasmic elongation of the poly(A) tail was originally identified as a mechanism to activate maternal mRNAs, stored as silent transcripts with short poly(A) tails, during meiotic progression. A family of RNA-binding proteins named CPEBs, which recruit the translational repression or cytoplasmic polyadenylation machineries to their target mRNAs, directly mediates cytoplasmic polyadenylation. Recent years have witnessed an explosion of studies showing that CPEBs are not only expressed in a variety of somatic tissues, but have essential functions controlling gene expression in time and space in the adult organism. These "new" functions of the CPEBs include regulating the balance between senescence and proliferation and its pathological manifestation, tumor development. In this review, we summarize current knowledge on the functions of the CPEB-family of proteins in the regulation of cell proliferation, their target mRNAs and the mechanism controlling their activities.
authors.affiliation: Institute for Research in Biomedicine (IRB Barcelona), Baldiri Reixac 10, Barcelona, 08028, Spain.
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Fernández-Miranda
authors.forename: Raúl
authors.initials: R
authors.lastname: Méndez
mesh_terms: D000375:Aging / Q000235:genetics*; D000818:Animals; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D014176:Protein Biosynthesis / Q000235:genetics*; D012323:RNA Processing, Post-Transcriptional / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics* / Q000502:physiology; D039221:mRNA Cleavage and Polyadenylation Factors / Q000235:genetics* / Q000502:physiology
chemical_list: C490386:CPEB1 protein, human; D014157:Transcription Factors; D039221:mRNA Cleavage and Polyadenylation Factors