title: Pressure-induced angioedema associated with endotracheal tube: successful treatment with epinephrine in two cases.
abstract: Pressure-induced urticaria is a non-immunoglobulin E-mediated type of urticaria. Some patients only have angioedema, and the term pressure-induced angioedema (PIA) is more appropriate for them. PIA has not previously been reported in association with endotracheal tube. Here we describe two patients who developed PIA after endotracheal intubation. There were no histories of angioedema, drug and food allergy in both patients. Tests for specific aero-allergens and latex were negative. Serum total immunoglobulin E and C4 levels were in normal ranges. Antihistamines and intravenous steroid therapy were ineffective. Angioedema regressed with intravenous epinephrine infusion and did not relapse after extubation.
  
  
  CONCLUSIONS
  We suggest that endotracheal tubes can cause PIA. Epinephrine therapy should be used early at treatment, especially in the patients who are at great risk for life-threatening airway problems.
authors.affiliation: Department of Pediatric Critical Care, Ankara University Faculty of Medicine, 06100 Ankara, Turkey. caglar_odek@hotmail.com
authors.forename: Cağlar
authors.initials: C
authors.lastname: Odek
authors.forename: Tanıl
authors.initials: T
authors.lastname: Kendirli
authors.forename: Funda
authors.initials: F
authors.lastname: Cipe
authors.forename: Banu
authors.initials: B
authors.lastname: Katlan
authors.forename: Figen
authors.initials: F
authors.lastname: Doğu
mesh_terms: D000799:Angioedema / Q000188:drug therapy / Q000209:etiology*; D002675:Child, Preschool; D004837:Epinephrine / Q000627:therapeutic use*; D006801:Humans; D007442:Intubation, Intratracheal / Q000009:adverse effects*; D008297:Male; D014662:Vasoconstrictor Agents / Q000627:therapeutic use*
chemical_list: D014662:Vasoconstrictor Agents; D004837:Epinephrine