title: Effect of broccoli sprouts on insulin resistance in type 2 diabetic patients: a randomized double-blind clinical trial.
abstract: Use of antioxidant components is a new approach for improvement of insulin resistance (IR) as a main feature of type 2 diabetes and its complications. The aim of this study was to investigate the effects of broccoli sprouts powder (BSP) containing high concentration of sulphoraphane on IR in type 2 diabetic patients. Eighty-one patients were randomly assigned to receive 10 g/d BSP (A, n = 27), 5 g/d BSP (B, n = 29) and placebo (C, n = 25) for 4 weeks. Fasting serum glucose and insulin concentration, glucose to insulin ratio and homoeostasis model assessment of IR (HOMA-IR) index were measured at baseline and again 4 weeks after treatment. Seventy-two patients completed the study and 63 were included in the analysis. After 4 weeks, consumption of 10 g/d BSP resulted in a significant decrease in serum insulin concentration and HOMA-IR (p = 0.05 for treatment effect). Therefore, broccoli sprouts may improve IR in type 2 diabetic patients.
authors.affiliation: Obesity Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Bahadoran
authors.forename: Maryam
authors.initials: M
authors.lastname: Tohidi
authors.forename: Pantea
authors.initials: P
authors.lastname: Nazeri
authors.forename: Mahya
authors.initials: M
authors.lastname: Mehran
authors.forename: Fereidoun
authors.initials: F
authors.lastname: Azizi
authors.forename: Parvin
authors.initials: P
authors.lastname: Mirmiran
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage / Q000009:adverse effects / Q000032:analysis / Q000627:therapeutic use*; D001786:Blood Glucose / Q000032:analysis; D001937:Brassica / Q000737:chemistry*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000178:diet therapy* / Q000378:metabolism; D019587:Dietary Supplements / Q000009:adverse effects / Q000032:analysis; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology / Q000517:prevention & control; D006946:Hyperinsulinism / Q000209:etiology / Q000517:prevention & control; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D007492:Iran; D017879:Isothiocyanates / Q000008:administration & dosage / Q000009:adverse effects / Q000032:analysis / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D010352:Patient Dropouts; D018520:Plant Shoots / Q000737:chemistry*; D013454:Sulfoxides
chemical_list: D000975:Antioxidants; D001786:Blood Glucose; D007328:Insulin; D017879:Isothiocyanates; D013454:Sulfoxides; C016766:sulforaphane