title: Integrin signaling in mammary epithelial cells and breast cancer.
abstract: Cells sense and respond to the extracellular matrix (ECM) by way of integrin receptors, which facilitate cell adhesion and intracellular signaling. Advances in understanding the mammary epithelial cell hierarchy are converging with new developments that reveal how integrins regulate the normal mammary gland. But in breast cancer, integrin signaling contributes to the development and progression of tumors. This paper highlights recent studies which examine the role of integrin signaling in mammary epithelial cells and their malignant counterparts.
authors.affiliation: Molecular Medicine Program, Biomedical Genetics Section, Department of Medicine, Boston University School of Medicine, 72 East Concord Street, L320, Boston, MA 02118, USA.
authors.forename: Arthur W
authors.initials: AW
authors.lastname: Lambert
authors.forename: Sait
authors.initials: S
authors.lastname: Ozturk
authors.forename: Sam
authors.initials: S
authors.lastname: Thiagalingam