title: Resuscitation-promoting factors (Rpf): in search of inhibitors.
abstract: Resuscitation promoting factors (Rpf) are a family of proteins secreted by actively growing actinobacteria, including Mycobacterium tuberculosis. Experimental evidence suggests that Rpfs play a distinct role in bacterial resuscitation and re-growth as well as reactivation of chronic tuberculosis in mice. The striking similarity of the Rpfs structure to cell wall hydrolysing enzymes has provided a basis for the development of novel low molecular weight inhibitors of Rpfs activity. In particular, recently characterised nitrophenylthiocyanate compounds could be considered as a promising scaffold for generation of therapeutic agents targeting reactivation of latent tuberculosis. This review describes recent progress in understanding of molecular mechanisms of Rpf biological activity.
authors.affiliation: A. N. Bach Institute of Biochemistry, RAS, Leninsky pr., 33, 119071, Moscow, Russia. arseny@inbi.ras.ru
authors.forename: Arseny S
authors.initials: AS
authors.lastname: Kaprelyants
authors.forename: Galina V
authors.initials: GV
authors.lastname: Mukamolova
authors.forename: Alessia
authors.initials: A
authors.lastname: Ruggiero
authors.forename: Vadim A
authors.initials: VA
authors.lastname: Makarov
authors.forename: Galina R
authors.initials: GR
authors.lastname: Demina
authors.forename: Margarita O
authors.initials: MO
authors.lastname: Shleeva
authors.forename: Vasilii D
authors.initials: VD
authors.lastname: Potapov
authors.forename: Pavel A
authors.initials: PA
authors.lastname: Shramko
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000037:antagonists & inhibitors*; D016207:Cytokines / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D051379:Mice; D009169:Mycobacterium tuberculosis / Q000472:pathogenicity*; D014376:Tuberculosis / Q000188:drug therapy*
chemical_list: D001426:Bacterial Proteins; D016207:Cytokines; D004791:Enzyme Inhibitors; C113704:resuscitation-promoting factor, bacteria