title: Survival benefit of early infant antiretroviral therapy is compromised when diagnosis is delayed.
abstract: Late presentation is common among African HIV-1-infected infants. Incidence and correlates of mortality were examined in 99 infants with HIV-1 diagnosis by 5 months of age. Twelve-month survival was 66.8% (95% confidence interval: 55.9-75.6%). World Health Organization stage 3 or 4, underweight, wasting, microcephaly, low hemoglobin, pneumonia and gastroenteritis predicted mortality. Early HIV-1 diagnosis with antiretroviral therapy before symptomatic disease is critical for infant survival.
authors.affiliation: Department of Paediatrics, University of Nairobi, Nairobi, Kenya. dalton@africaonline.co.ke
authors.forename: Dalton
authors.initials: D
authors.lastname: Wamalwa
authors.forename: Sarah
authors.initials: S
authors.lastname: Benki-Nugent
authors.forename: Agnes
authors.initials: A
authors.lastname: Langat
authors.forename: Ken
authors.initials: K
authors.lastname: Tapia
authors.forename: Evelyn
authors.initials: E
authors.lastname: Ngugi
authors.forename: Jennifer A
authors.initials: JA
authors.lastname: Slyker
authors.forename: Barbra A
authors.initials: BA
authors.lastname: Richardson
authors.forename: Grace C
authors.initials: GC
authors.lastname: John-Stewart
mesh_terms: D019380:Anti-HIV Agents / Q000008:administration & dosage*; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods*; D057210:Delayed Diagnosis; D005260:Female; D015658:HIV Infections / Q000175:diagnosis* / Q000188:drug therapy* / Q000401:mortality / Q000821:virology; D015497:HIV-1 / Q000302:isolation & purification; D006801:Humans; D007223:Infant; D008297:Male; D016019:Survival Analysis
chemical_list: D019380:Anti-HIV Agents