title: Association of genetic polymorphisms with personality profile in individuals without psychiatric disorders.
abstract: OBJECTIVE
  Population-based twin studies demonstrate that approximately 40-50% of the variability in personality dimensions results from genetic factors. This study assessed selected polymorphisms in the COMT Val158Met, MAOA 3'VNTR, 5HTTLPR, 102T/C 5-HT2A, DAT 3'VNTR and DRD2 exon 8 genes and evaluated their association with personality profiles, anxiety levels, and depressiveness in healthy subjects.
  
  
  METHODS
  This study included 406 unrelated (mean age 38.51 years), mentally and somatically healthy Caucasian subjects of Polish origin. The prevalence of the gene variants mentioned above and their association with personality profiles, anxiety levels, and depressiveness was assessed using the Temperament and Character Inventory, NEO Five-Factor Inventory, Spielberger's State-Trait Anxiety Inventory and Beck's Depression Inventory.
  
  
  RESULTS
  The effects of the 5HTTLPR gene on the s/s genotype and empathy (C2) were lowest in the entire group. The effects of gender, age and the HT2A gene for the T/T genotype and attachment (RD3) were highest in women. The effects of gender, age and the DAT gene on the 9/9 DAT genotype, compassion (C4) and cooperativeness (C) were lowest in women. The effects of gender, age and the COMT gene on the Met/Met genotype and neuroticism (NEU) NEO-FFI were also lowest in women.
  
  
  CONCLUSIONS
  Our results suggest considerable influence of individual genes on the formation of personality traits.
authors.affiliation: Department of Psychiatry, Pomeranian Medical University, Broniewskiego 26, 71-460 Szczecin, Poland.
authors.forename: Justyna
authors.initials: J
authors.lastname: Pełka-Wysiecka
authors.forename: Joanna
authors.initials: J
authors.lastname: Ziętek
authors.forename: Anna
authors.initials: A
authors.lastname: Grzywacz
authors.forename: Jolanta
authors.initials: J
authors.lastname: Kucharska-Mazur
authors.forename: Przemysław
authors.initials: P
authors.lastname: Bienkowski
authors.forename: Jerzy
authors.initials: J
authors.lastname: Samochowiec
mesh_terms: D000328:Adult; D000367:Age Factors; D002394:Catechol O-Methyltransferase / Q000235:genetics; D050483:Dopamine Plasma Membrane Transport Proteins / Q000235:genetics; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008995:Monoamine Oxidase / Q000235:genetics; D010551:Personality / Q000235:genetics*; D010555:Personality Inventory / Q000706:statistics & numerical data; D011110:Polymorphism, Genetic / Q000235:genetics*; D044402:Receptor, Serotonin, 5-HT2A / Q000235:genetics; D017448:Receptors, Dopamine D2 / Q000235:genetics; D050486:Serotonin Plasma Membrane Transport Proteins / Q000235:genetics; D012727:Sex Characteristics; D044465:White People / Q000235:genetics / Q000523:psychology
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; D044402:Receptor, Serotonin, 5-HT2A; D017448:Receptors, Dopamine D2; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D008995:Monoamine Oxidase; D002394:Catechol O-Methyltransferase