title: Aging of budding yeast.
abstract: Accumulation of insoluble (i.e., aggregated, cross-linked) protein is proposed to be a major cause of aging of the budding yeast cell Saccharomyces cerevisiae. This may give rise to the Lansing effect--precocious aging of parthenogenetically propagated daughters from old mothers--and to the genomic instability observed in old cells.
authors.affiliation: Department of Medical Biochemistry and Microbiology, University of Uppsala, Uppsala, Sweden. anundhallen@swipnet.se
authors.forename: Anund
authors.initials: A
authors.lastname: Hallén
mesh_terms: D000375:Aging; D002455:Cell Division; D018385:Centrosome / Q000648:ultrastructure; D002869:Chromosome Aberrations; D042822:Genomic Instability; D006801:Humans; D008957:Models, Genetic; D008962:Models, Theoretical; D011506:Proteins / Q000737:chemistry; D012441:Saccharomyces cerevisiae / Q000502:physiology*; D004718:Saccharomycetales / Q000235:genetics* / Q000502:physiology*; D012995:Solubility; D013997:Time Factors
chemical_list: D011506:Proteins