title: The 'complexities' of life and death: death receptor signalling platforms.
abstract: Cell death is critical to the normal functioning of multi-cellular organisms, playing a central role in development, immunity, inflammation, and cancer progression. Two cell death mechanisms, apoptosis and necroptosis, are dependent on the formation of distinct multi-protein complexes including the DISC, Apoptosome, Piddosome and Necrosome following the induction of cell death by specific stimuli. The role of several of these key multi-protein signalling platforms, namely the DISC, TNFR1 complex I/II, the Necrosome and Ripoptosome, in mediating these pathways will be discussed, as well as the open questions and potential therapeutic benefits of understanding their underlying mechanisms.
authors.affiliation: MRC Toxicology Unit, University of Leicester, Leicester, UK.
authors.forename: Laura S
authors.initials: LS
authors.lastname: Dickens
authors.forename: Ian R
authors.initials: IR
authors.lastname: Powley
authors.forename: Michelle A
authors.initials: MA
authors.lastname: Hughes
authors.forename: Marion
authors.initials: M
authors.lastname: MacFarlane
mesh_terms: D000818:Animals; D016923:Cell Death; D006801:Humans; D046912:Multiprotein Complexes; D053218:Receptors, Death Domain / Q000378:metabolism / Q000502:physiology*; D015398:Signal Transduction
chemical_list: D046912:Multiprotein Complexes; D053218:Receptors, Death Domain