title: Alkene synthesis through transition metal-catalyzed cross-coupling of N-tosylhydrazones.
abstract: In this chapter, alkene synthesis based on the reaction of N-tosylhydrazones is described. The reactivity of tosylhydrazones is determined by either the acidity of α-proton and hydrazone proton or the electropositivity of the carbon of C=N bond. This leads to diverse reactivities and a series of N-tosylhydrazone-based olefination methodologies. Both non-catalytic and transition metal-catalyzed olefinations from N-tosylhydrazones are introduced in this chapter. Most of the transition metal-catalyzed reactions proceed via metal carbene transformations. The synthesis of alkenes through Pd-catalyzed cross-coupling reactions of N-tosylhydrazones is particularly attractive and will be discussed in detail.
authors.affiliation: Peking University, Beijing, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhang
authors.forename: Jianbo
authors.initials: J
authors.lastname: Wang
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis*; D002384:Catalysis; D006835:Hydrazones / Q000737:chemistry*; D015394:Molecular Structure; D028561:Transition Elements / Q000494:pharmacology*
chemical_list: D000475:Alkenes; D006835:Hydrazones; D028561:Transition Elements