title: [Fear memory extinction accelerated by simultaneous activation of GABA(B) and NMDA receptors].
abstract: Effects of the N-methyl-D-aspartate (NMDA) agonist (D-cycloserine) and GABA(B) agonist (baclofen) on the fear memory extinction as manifested in the passive avoidance reaction in C57Bl/6J mice with "behavioral despair" (model of depression) and without previously developed stress have been studied. The positive acceleration of the fear memory extinction was observed in depressive mice upon the simultaneous administration of D-cycloserine and baclofen.
authors.forename: N I
authors.initials: NI
authors.lastname: Dubrovina
mesh_terms: D000818:Animals; D000963:Antimetabolites / Q000494:pharmacology; D001362:Avoidance Learning / Q000187:drug effects; D001418:Baclofen / Q000494:pharmacology*; D003523:Cycloserine / Q000494:pharmacology*; D003863:Depression / Q000188:drug therapy* / Q000523:psychology; D005108:Extinction, Psychological / Q000187:drug effects; D005239:Fear / Q000187:drug effects* / Q000523:psychology; D058786:GABA-B Receptor Agonists / Q000494:pharmacology; D008297:Male; D008568:Memory / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D018080:Receptors, GABA-B / Q000378:metabolism; D016194:Receptors, N-Methyl-D-Aspartate / Q000819:agonists
chemical_list: D000963:Antimetabolites; D058786:GABA-B Receptor Agonists; D018080:Receptors, GABA-B; D016194:Receptors, N-Methyl-D-Aspartate; D003523:Cycloserine; D001418:Baclofen