title: Takotsubo cardiomyopathy: its possible impact during adult donor care.
abstract: Takotsubo cardiomyopathy, the syndrome caused by an extreme release and circulation of catecholamines, shares several histopathological and clinical similarities with cardiac changes after brain death noted in animal investigations and human observation. Overwhelming stimulation of myocardial inotropic β receptors may alter their responsiveness and induce other biochemical processes, producing reduced cardiac contractility. Treatment methods in Takotsubo cardiomyopathy that use extracorporeal circulatory support and medications that do not rely on β-receptor stimulation and preemptive blockade of β receptors or calcium channels before brain death may be relevant to donor care.
authors.affiliation: Vivian L. Smith Department of Neurosurgery, University of Texas Health Sciences Center at Houston Medical School, USA. djpowner@gmail.com
authors.forename: David J
authors.initials: DJ
authors.lastname: Powner
authors.forename: Hanh
authors.initials: H
authors.lastname: Truong
mesh_terms: D000328:Adult; D002317:Cardiovascular Agents / Q000627:therapeutic use; D004452:Echocardiography; D015199:Extracorporeal Membrane Oxygenation; D006801:Humans; D054549:Takotsubo Cardiomyopathy / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy*; D014019:Tissue Donors
chemical_list: D002317:Cardiovascular Agents