title: Genetic variants in interleukin-2 and risk of lymphoma among children in Korea.
abstract: To estimate the genetic susceptibility for childhood lymphoma, we conducted an association study for 23 cases and 148 controls. Total 1536 tag single nucleotide polymorphisms (SNPs) were selected in 138 candidate gene regions related to immune responses, apoptosis, the cell cycle, and DNA repair. Twelve SNPs were significantly associated with the risk of lymphoma (P(trend)<0.05) in six genes (IL1RN, IL2, IL12RB1, JAK3, TNFRSF13B, and XRCC3). The most significant association was seen for IL2 variant rs2069762 (OR(TG+GG) vs. TT=3.43 (1.29-9.11), P(trend)=0.002, minP=0.005). These findings suggest that common genetic variants in IL2 might play a role in the pathogenesis of childhood lymphoma.
authors.affiliation: Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology and College of Medicine, Seoul National University, Seoul, Korea.
authors.forename: Nan
authors.initials: N
authors.lastname: Song
authors.forename: Sohee
authors.initials: S
authors.lastname: Han
authors.forename: Kyoung-Mu
authors.initials: KM
authors.lastname: Lee
authors.forename: Ji-Yeob
authors.initials: JY
authors.lastname: Choi
authors.forename: Sue K
authors.initials: SK
authors.lastname: Park
authors.forename: Sujee
authors.initials: S
authors.lastname: Jeon
authors.forename: Yunhee
authors.initials: Y
authors.lastname: Lee
authors.forename: Hyo Seop
authors.initials: HS
authors.lastname: Ahn
authors.forename: Hee Young
authors.initials: HY
authors.lastname: Shin
authors.forename: Hyoung Jin
authors.initials: HJ
authors.lastname: Kang
authors.forename: Hong Hoe
authors.initials: HH
authors.lastname: Koo
authors.forename: Jong Jin
authors.initials: JJ
authors.lastname: Seo
authors.forename: Ji Eun
authors.initials: JE
authors.lastname: Choi
authors.forename: Daehee
authors.initials: D
authors.lastname: Kang
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007376:Interleukin-2 / Q000235:genetics*; D008223:Lymphoma / Q000235:genetics* / Q000473:pathology*; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011379:Prognosis; D012307:Risk Factors; D055815:Young Adult
chemical_list: D007376:Interleukin-2