title: Endogenous modifiers of cigarette smoke exposure within the lung.
abstract: Cigarette smoke exposure generates both acute and chronic inflammatory cell infiltrates that are operative in numerous pulmonary disorders. Cigarette smoke induces a complex signaling cascade within the lung mediated by epithelial cells, lymphocytes, macrophages, and others. The net result is a destructive and self-perpetuating inflammatory environment that is capable of creating lung diseases such as emphysema, while simultaneously fueling lung tumor growth using both matrix-dependent and -independent means.
authors.affiliation: University of Pittsburgh School of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Pittsburgh, PA 15261, USA. houghtonm@dom.pitt.edu
authors.forename: A McGarry
authors.initials: AM
authors.lastname: Houghton
mesh_terms: D006801:Humans; D007249:Inflammation / Q000276:immunology / Q000378:metabolism; D019272:Leukocyte Elastase / Q000276:immunology / Q000378:metabolism; D008168:Lung / Q000201:enzymology / Q000276:immunology*; D008175:Lung Neoplasms / Q000201:enzymology / Q000276:immunology*; D009504:Neutrophils / Q000201:enzymology / Q000276:immunology; D029424:Pulmonary Disease, Chronic Obstructive / Q000201:enzymology / Q000276:immunology*; D011656:Pulmonary Emphysema / Q000201:enzymology / Q000276:immunology*; D012907:Smoking / Q000276:immunology* / Q000378:metabolism
chemical_list: D019272:Leukocyte Elastase