title: Mitigating heterocycle metabolism in drug discovery.
authors.affiliation: Department of Therapeutic Discovery, Amgen, Inc, Thousand Oaks, CA 91320, USA.
authors.forename: David J
authors.initials: DJ
authors.lastname: St Jean
authors.forename: Christopher
authors.initials: C
authors.lastname: Fotsch
mesh_terms: D000818:Animals; D001711:Biotransformation; D016208:Databases, Factual; D055808:Drug Discovery / Q000379:methods*; D004347:Drug Interactions; D006573:Heterocyclic Compounds, 1-Ring / Q000737:chemistry / Q000378:metabolism*; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D051379:Mice; D004364:Pharmaceutical Preparations / Q000737:chemistry / Q000378:metabolism*; D051381:Rats
chemical_list: D006573:Heterocyclic Compounds, 1-Ring; D006576:Heterocyclic Compounds, 4 or More Rings; D004364:Pharmaceutical Preparations