title: [Physiology, pharmacology and modelling of potassium channels: focus on SK channels].
abstract: Various types of ion channels are involved in the control of neuronal activity. Among them, SK channels represent an interesting therapeutic target. Indeed, they underlie medium duration after hyperpolarizations in many types of neurons, thus inhibiting cell excitability. A thorough knowledge of the physiology of these channels and the discovery of non-peptidic selective modulators able to cross the blood-brain barrier are essential in view of developing future drugs for brain diseases such as those related to a dysfunction of dopaminergic and serotonergic systems.
authors.affiliation: Laboratoire de chimie pharmaceutique et centre interfacultaire de recherche du médicament (CIRM), université de Liège, 1, avenue de l'hôpital, 4000 Liège, Belgique. sdilly@ulg.ac.be
authors.forename: Sébastien
authors.initials: S
authors.lastname: Dilly
authors.forename: Sylvie
authors.initials: S
authors.lastname: Poncin
authors.forename: Cédric
authors.initials: C
authors.lastname: Lamy
authors.forename: Jean-François
authors.initials: JF
authors.lastname: Liégeois
authors.forename: Vincent
authors.initials: V
authors.lastname: Seutin
mesh_terms: D000818:Animals; D006801:Humans; D008564:Membrane Potentials / Q000187:drug effects / Q000235:genetics / Q000502:physiology; D008954:Models, Biological; D008958:Models, Molecular; D011188:Potassium / Q000378:metabolism; D026902:Potassium Channel Blockers / Q000494:pharmacology*; D015221:Potassium Channels / Q000819:agonists* / Q000737:chemistry* / Q000235:genetics / Q000502:physiology*; D051640:Small-Conductance Calcium-Activated Potassium Channels / Q000819:agonists / Q000037:antagonists & inhibitors / Q000737:chemistry / Q000502:physiology; D013379:Substrate Specificity
chemical_list: D026902:Potassium Channel Blockers; D015221:Potassium Channels; D051640:Small-Conductance Calcium-Activated Potassium Channels; D011188:Potassium