title: The survival impact of systematic lymphadenectomy in endometrial cancer with the use of propensity score matching analysis.
abstract: OBJECTIVE
  We sought to evaluate whether patients with endometrial cancer in the Surveillance, Epidemiology, and End Results database who underwent lymphadenectomy demonstrate improved survival.
  
  
  METHODS
  The study population comprised 50,969 patients. The 3-year cause-specific survival was tested by using propensity score matching (PSM) analysis.
  
  
  RESULTS
  The PSM analysis generated a balanced, matched cohort in which baseline characteristics were not significantly different. The benefit of systematic lymphadenectomy appears to be significant for presumed stage I International Federation of Gynecology and Obstetrics grade 3 cancers and presumed stages II-III cancer. The omission of lymphadenectomy in stage I did not appear to show a deleterious survival consequence if the differentiation grade was moderate (grade 2) or well (grade 1).
  
  
  CONCLUSIONS
  Using PSM analysis, our results show no evidence of benefit in terms of survival for systematic lymphadenectomy in women with stage I endometrial cancer, except for grade 3 cancers.
authors.affiliation: Department of Obstetrics and Gynecology, Hospital Tenon, APHP (Assistance Publique des Hôpitaux de Paris), Paris, France. sofiane.bendifallah@yahoo.fr
authors.forename: Sofiane
authors.initials: S
authors.lastname: Bendifallah
authors.forename: Martin
authors.initials: M
authors.lastname: Koskas
authors.forename: Marcos
authors.initials: M
authors.lastname: Ballester
authors.forename: Anne-Sophie
authors.initials: AS
authors.lastname: Genin
authors.forename: Emile
authors.initials: E
authors.lastname: Darai
authors.forename: Roman
authors.initials: R
authors.lastname: Rouzier
mesh_terms: D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D000328:Adult; D000368:Aged; D016889:Endometrial Neoplasms / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008197:Lymph Node Excision; D008875:Middle Aged; D015999:Multivariate Analysis; D060787:Neoplasm Grading; D009367:Neoplasm Staging; D010388:Pelvis; D057216:Propensity Score; D012189:Retrospective Studies; D018426:SEER Program; D016019:Survival Analysis; D016896:Treatment Outcome