title: Regulation of spike timing-dependent plasticity of olfactory inputs in mitral cells in the rat olfactory bulb.
abstract: The recent history of activity input onto granule cells (GCs) in the main olfactory bulb can affect the strength of lateral inhibition, which functions to generate contrast enhancement. However, at the plasticity level, it is unknown whether and how the prior modification of lateral inhibition modulates the subsequent induction of long-lasting changes of the excitatory olfactory nerve (ON) inputs to mitral cells (MCs). Here we found that the repetitive stimulation of two distinct excitatory inputs to the GCs induced a persistent modification of lateral inhibition in MCs in opposing directions. This bidirectional modification of inhibitory inputs differentially regulated the subsequent synaptic plasticity of the excitatory ON inputs to the MCs, which was induced by the repetitive pairing of excitatory postsynaptic potentials (EPSPs) with postsynaptic bursts. The regulation of spike timing-dependent plasticity (STDP) was achieved by the regulation of the inter-spike-interval (ISI) of the postsynaptic bursts. This novel form of inhibition-dependent regulation of plasticity may contribute to the encoding or processing of olfactory information in the olfactory bulb.
authors.affiliation: Department of Neurobiology, Nanjing Medical University, Nanjing, Jiangsu Province, People's Republic of China.
authors.forename: Teng-Fei
authors.initials: TF
authors.lastname: Ma
authors.forename: Xiao-Lei
authors.initials: XL
authors.lastname: Zhao
authors.forename: Lei
authors.initials: L
authors.lastname: Cai
authors.forename: Nan
authors.initials: N
authors.lastname: Zhang
authors.forename: Si-Qiang
authors.initials: SQ
authors.lastname: Ren
authors.forename: Fang
authors.initials: F
authors.lastname: Ji
authors.forename: Tian
authors.initials: T
authors.lastname: Tian
authors.forename: Wei
authors.initials: W
authors.lastname: Lu
mesh_terms: D000200:Action Potentials; D000818:Animals; D004558:Electric Stimulation; D019706:Excitatory Postsynaptic Potentials; D018755:GABA Agonists / Q000494:pharmacology; D018756:GABA Antagonists / Q000494:pharmacology; D059330:GABAergic Neurons / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D007539:Isonicotinic Acids / Q000494:pharmacology; D009433:Neural Inhibition; D009473:Neuronal Plasticity; D009474:Neurons / Q000502:physiology; D009830:Olfactory Bulb / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D009832:Olfactory Nerve / Q000502:physiology*; D011724:Pyridazines / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D018755:GABA Agonists; D018756:GABA Antagonists; D007539:Isonicotinic Acids; D011724:Pyridazines; C049853:gabazine; C015300:isoguvacine