title: Influence of local or systemic corticosteroids on skin wound healing resistance.
abstract: OBJECTIVE
  To compare the resistance of skin wound healing of mice submitted to local or systemic hydrocortisone administration, in different postoperative periods.
  
  
  METHODS
  An incision and suture was performed on the thoracic skin of 130 male mice: Group 1 (n = 10) resistance of the integer skin; Group 2 (n = 30) submitted only to skin incision and suture; Group 3 (n = 30) skin incision and suture followed by administration of saline fluid; Group 4 (n = 30) skin incision and suture followed by administration of local hydrocortisone; Group 5 (n = 30) skin incision and suture followed by administration of systemic hydrocortisone. The resistance of the wound healing and the weight of the animals were studied on the seventh, 14(th) and 21(st) postoperative days. Histological examination was also performed.
  
  
  RESULTS
  The mice that received corticoid (groups 4 and 5) presented significant decreasing on their weight (p = 0.02). The Groups 3, 4 and 5 showed lower scar resistance than Group 2 on the seventh postoperative day (p < 0.05). On the 14(th) and 21(st) days, there was no difference on the skin would healing resistance (p > 0.05).
  
  
  CONCLUSIONS
  Administration of hydrocortisone in mice is responsible for weight decreasing and reduction of the skin wound healing resistance during the first postoperative week.
authors.affiliation: Department of Surgery, UFMG, Brazil.
authors.forename: Luiz Ronaldo
authors.initials: LR
authors.lastname: Alberti
authors.forename: Leonardo de Souza
authors.initials: Lde S
authors.lastname: Vasconcellos
authors.forename: Andy
authors.initials: A
authors.lastname: Petroianu
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D006854:Hydrocortisone / Q000008:administration & dosage*; D008297:Male; D051379:Mice; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology
chemical_list: D000893:Anti-Inflammatory Agents; D006854:Hydrocortisone