title: Synthesis of alcohols from m-fluorophenylsulfones and dialkylboranes: application to the C14-C35 building block of E7389.
abstract: The reaction of m-fluorophenylsulfone anions with dialkylboranes, followed by alkaline hydroperoxide oxidation, yields alcohols in high yields. Optimization of the process, scope and limitation, and application to the synthesis of one of the C14-C35 building blocks of E7389, a right half analogue of halichondrin B, are reported.
authors.affiliation: Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, United States.
authors.forename: Lei
authors.initials: L
authors.lastname: Liu
authors.forename: James A
authors.initials: JA
authors.lastname: Henderson
authors.forename: Akihiko
authors.initials: A
authors.lastname: Yamamoto
authors.forename: Paul
authors.initials: P
authors.lastname: Brémond
authors.forename: Yoshito
authors.initials: Y
authors.lastname: Kishi