title: Synthesis of norlignans and in vitro inhibitory activity of antigen-induced degranulation.
abstract: The synthesis and biological evaluation of a series of novel norlignans are described. Norlignans were evaluated for their inhibitory activity on the release of β-hexosaminidase, a marker of degranulation, from RBL-2H3 cells induced by the IgE-antigen complex. The results showed that norlignans 4c and 4e potently inhibited degranulation, with IC(50) values of 18.3 and 17.9 μM, respectively.
authors.affiliation: College of Pharmacy, Kyung Hee University, Seoul, Republic of Korea.
authors.forename: Eonjeong
authors.initials: E
authors.lastname: Park
authors.forename: Yoon Jung
authors.initials: YJ
authors.lastname: Yang
authors.forename: Aejin
authors.initials: A
authors.lastname: Kim
authors.forename: Jong Hwan
authors.initials: JH
authors.lastname: Kwak
authors.forename: Young Hoon
authors.initials: YH
authors.lastname: Jung
authors.forename: Se Chan
authors.initials: SC
authors.lastname: Kang
authors.forename: In Su
authors.initials: IS
authors.lastname: Kim
mesh_terms: D000818:Animals; D000936:Antigen-Antibody Complex / Q000276:immunology*; D001491:Basophils / Q000502:physiology; D015550:Cell Degranulation / Q000187:drug effects*; D045744:Cell Line, Tumor; D007073:Immunoglobulin E / Q000737:chemistry / Q000378:metabolism; D017705:Lignans / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship; D001619:beta-N-Acetylhexosaminidases / Q000378:metabolism
chemical_list: D000936:Antigen-Antibody Complex; D017705:Lignans; D007073:Immunoglobulin E; D001619:beta-N-Acetylhexosaminidases