title: Neonatal outcome of the pregnancies associated with placental villous thrombosis - thrombophilic status of the mothers and the infants.
abstract: OBJECTIVE
  To analyze the relationship of obstetric complications and neonatal outcomes with the thrombophilic status of the mother-infant couples in case of demonstrated placental villous thrombosis in histopathological evaluation after delivery.
  
  
  METHODS
  Placentas of high-risk pregnancies, unexplained fetal loss or infants who needed neonatal intensive care unit (NICU) admission were collected at the time of delivery.
  
  
  RESULTS
  In a 6 months period, placental villous thrombosis was detected in 30 among 800 placentas. Half of the mothers had a bad obstetric outcome previously, such as at least one abortus or stillbirth. Eighteen neonates (60%) were premature. Seventy-five percent of the neonates (n = 24) needed NICU admission and the mortality rate was 9.3 %. Five of the patients had congenital anomalies. Thrombophilic mutations could be evaluated in seven mothers-infant couples, all of whom had at least one positive mutation for thrombosis.
  
  
  CONCLUSIONS
  Severe fetal vasculopathy appears to be a predisposing factor for adverse neonatal outcomes. Analyzing placentas will yield advantages as the same pathological process may repeat in subsequent pregnancies. Thrombophilic mutations should be evaluated to provide the etiology of the adverse outcome and to give prophylaxis for the future pregnancies.
authors.affiliation: Zekai Tahir Burak Maternity Teaching Hospital, Division of Neonatology, Ankara, Turkey. kgamze@hotmail.com
authors.forename: Gamze
authors.initials: G
authors.lastname: Demirel
authors.forename: Istemi Han
authors.initials: IH
authors.lastname: Celik
authors.forename: Sema
authors.initials: S
authors.lastname: Zergeroglu
authors.forename: Omer
authors.initials: O
authors.lastname: Erdeve
authors.forename: Ugur
authors.initials: U
authors.lastname: Dilmen
mesh_terms: D000328:Adult; D002824:Chorionic Villi / Q000473:pathology; D005260:Female; D006801:Humans; D007231:Infant, Newborn / Q000097:blood / Q000502:physiology; D007232:Infant, Newborn, Diseases / Q000175:diagnosis / Q000453:epidemiology; D008297:Male; D009035:Mothers / Q000706:statistics & numerical data; D010922:Placenta Diseases / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000175:diagnosis / Q000453:epidemiology*; D011256:Pregnancy Outcome / Q000453:epidemiology*; D011379:Prognosis; D011644:Puerperal Disorders / Q000175:diagnosis / Q000453:epidemiology; D019851:Thrombophilia / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology; D013927:Thrombosis / Q000175:diagnosis* / Q000453:epidemiology / Q000473:pathology