title: New domino heteroannulation of enaminones: synthesis of diverse fused naphthyridines.
abstract: A series of new poly-functionalized fused naphthyridine derivatives were synthesized via a three-component reaction of aldehyde, 2-aminoprop-1-ene-1,1,3-tricarbonitrile and enaminone in EtOH using EtONa as a base. During these reaction processes, the domino construction of fused naphthyridine skeleton with concomitant formation of two new pyridine rings was readily achieved via base promoted three-component reactions in a one-pot operation. The procedures are facile, avoiding time-consuming and costly syntheses, tedious work-up and purifications of precursors.
authors.affiliation: School of Chemistry and Chemical Engineering, and Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials, Jiangsu Normal University, Jiangsu, PR China.
authors.forename: Jing
authors.initials: J
authors.lastname: Li
authors.forename: Yan
authors.initials: Y
authors.lastname: Yu
authors.forename: Man-Su
authors.initials: MS
authors.lastname: Tu
authors.forename: Bo
authors.initials: B
authors.lastname: Jiang
authors.forename: Shu-Liang
authors.initials: SL
authors.lastname: Wang
authors.forename: Shu-Jiang
authors.initials: SJ
authors.lastname: Tu
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D009287:Naphthyridines / Q000138:chemical synthesis* / Q000737:chemistry; D009570:Nitriles / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry
chemical_list: D000447:Aldehydes; D009287:Naphthyridines; D009570:Nitriles; D011725:Pyridines