title: Does Cholecystectomy Increase the Esophageal Alkaline Reflux? Evaluation by Impedance-pH Technique.
abstract: OBJECTIVE
  The aim of this study is to investigate the reflux patterns in patients with galbladder stone and the change of reflux patterns after cholecystectomy in such patients.
  
  
  METHODS
  Fourteen patients with cholecystolithiasis and a control group including 10 healthy control subjects were enrolled in this prospective study. Demographical findings, reflux symptom score scale and 24-hour impedance pH values of the 14 cholecystolithiasis cases and the control group were evaluated. The impedance pH study was repeated 3 months after cholecystectomy.
  
  
  RESULTS
  Age, gender, and BMI were not different between the two groups. Total and supine weakly alkaline reflux time (%) (1.0 vs 22.5, P = 0.028; 201.85 vs 9.65, P = 0.012), the longest episodes of total, upright and supine weakly alkaline reflux mediums (11 vs 2, P = 0.025; 8.5 vs 1.0, P = 0.035; 3 vs 0, P = 0.027), total and supine weakly alkaline reflux time in minutes (287.35 vs 75.10, P = 0.022; 62.5 vs 1.4, P = 0.017), the number of alkaline reflux episodes (162.5 vs 72.5, P = 0.022) were decreased with statistical significance. No statistically significant difference was found in the comparison of symptoms between the subjects in the control group and the patients with cholecystolithiasis, in preoperative, postoperative and postcholecystectomy status.
  
  
  CONCLUSIONS
  Significant reflux symptoms did not occur after cholecystectomy. Post cholecystectomy weakly alkaline reflux was decreased, but it was determined that acid reflux increased after cholecystectomy by impedance pH-metry in the study group.
authors.affiliation: Department of Gastroenterology, Harran University Faculty of Medicine, Sanliurfa, Turkey.
authors.forename: Ahmet
authors.initials: A
authors.lastname: Uyanikoglu
authors.forename: Filiz
authors.initials: F
authors.lastname: Akyuz
authors.forename: Fatih
authors.initials: F
authors.lastname: Ermis
authors.forename: Serpil
authors.initials: S
authors.lastname: Arici
authors.forename: Gurhan
authors.initials: G
authors.lastname: Bas
authors.forename: Mustafa
authors.initials: M
authors.lastname: Cakirca
authors.forename: Bulent
authors.initials: B
authors.lastname: Baran
authors.forename: Zeynel
authors.initials: Z
authors.lastname: Mungan