title: The intracellular controlled release from bioresponsive mesoporous silica with folate as both targeting and capping agent.
abstract: A smart mesoporous silica nanocarrier with intracellular controlled release is fabricated, with folic acid as dual-functional targeting and capping agent. The folate not only improves the efficiency of the nanocarrier internalized by the cancer cells, but also blocks the pores of the mesoporous silica to eliminate premature leakage of the drug. With disulfide bonds as linkers to attach the dual-functional folate within the surface of mesoporous silica, the controlled release can be triggered in the presence of reductant dithiothreitol (DTT) or glutathione (GSH). The cellular internalization via folate-receptor-mediated endocytosis and the intracellular controlled release of highly toxic anticancer drug DOX were demonstrated with an in vitro HeLa cell culture, indicating an efficient cancer-targeted drug delivery.
authors.affiliation: School of Chemical Biology and Pharmaceutics, Capital Medical University, Beijing 100069, China.
authors.forename: Rui
authors.initials: R
authors.lastname: Guo
authors.forename: Le-Le
authors.initials: LL
authors.lastname: Li
authors.forename: Wen-Hua
authors.initials: WH
authors.lastname: Zhao
authors.forename: Yu-Xi
authors.initials: YX
authors.lastname: Chen
authors.forename: Xiao-Zhu
authors.initials: XZ
authors.lastname: Wang
authors.forename: Chen-Jie
authors.initials: CJ
authors.lastname: Fang
authors.forename: Wei
authors.initials: W
authors.lastname: Feng
authors.forename: Tian-Lan
authors.initials: TL
authors.lastname: Zhang
authors.forename: Xiang
authors.initials: X
authors.lastname: Ma
authors.forename: Meng
authors.initials: M
authors.lastname: Lu
authors.forename: Shi-Qi
authors.initials: SQ
authors.lastname: Peng
authors.forename: Chun-Hua
authors.initials: CH
authors.lastname: Yan
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000633:toxicity; D017209:Apoptosis / Q000187:drug effects; D004229:Dithiothreitol / Q000737:chemistry; D004317:Doxorubicin / Q000737:chemistry / Q000633:toxicity; D004337:Drug Carriers / Q000737:chemistry*; D005492:Folic Acid / Q000737:chemistry*; D005978:Glutathione / Q000737:chemistry / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry*; D016062:Porosity; D012235:Rhodamines / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D012235:Rhodamines; D012822:Silicon Dioxide; D004317:Doxorubicin; D005492:Folic Acid; D005978:Glutathione; C029773:rhodamine B; D004229:Dithiothreitol