title: Natural killer cell mediated pathogenesis determines outcome of central nervous system infection with Venezuelan equine encephalitis virus in C3H/HeN mice.
abstract: TC83 is a human vaccine with investigational new drug status and is used as a prototype Venezuelan equine encephalitis virus for pathogenesis and antiviral research. Differing from other experimental models, the virus causes high titer infection in the brain and 90-100% mortality in the C3H/HeN murine model. To better characterize the susceptibility to disease development in C3H/HeN mice, we have analyzed the gene transcriptomes and cytokine production in the brains of infected mice. Our analysis indicated the potential importance of natural killer cells in the encephalitic disease development. This paper describes for the first time a pathogenic role for natural killer cells in VEEV encephalitis.
authors.affiliation: Sealy Center for Vaccine Development, Galveston National Lab, Department of Pathology, University of Texas Medical Branch, Galveston, TX 77550, USA. kattaylo@utmb.edu
authors.forename: Katherine
authors.initials: K
authors.lastname: Taylor
authors.forename: Olga
authors.initials: O
authors.lastname: Kolokoltsova
authors.forename: Michael
authors.initials: M
authors.lastname: Patterson
authors.forename: Allison
authors.initials: A
authors.lastname: Poussard
authors.forename: Jennifer
authors.initials: J
authors.lastname: Smith
authors.forename: D Mark
authors.initials: DM
authors.lastname: Estes
authors.forename: Slobodan
authors.initials: S
authors.lastname: Paessler
mesh_terms: D000818:Animals; D001921:Brain / Q000473:pathology / Q000821:virology; D016207:Cytokines / Q000378:metabolism; D004195:Disease Models, Animal; D004666:Encephalitis Virus, Venezuelan Equine / Q000276:immunology* / Q000472:pathogenicity*; D004685:Encephalomyelitis, Venezuelan Equine / Q000276:immunology* / Q000401:mortality / Q000473:pathology*; D020869:Gene Expression Profiling; D007694:Killer Cells, Natural / Q000276:immunology*; D051379:Mice; D008809:Mice, Inbred C3H; D016019:Survival Analysis
chemical_list: D016207:Cytokines