title: Fatal Canid herpesvirus 1 infection in an adult dog.
abstract: Canid herpesvirus 1 (CaHV-1) is a well-known cause of fatal hepatic and renal necrosis in neonatal puppies. In adult dogs infected with CaHV-1, papulovesicular genital lesions may be observed. CaHV-1 infection during pregnancy can lead to embryonic resorption, abortion, and stillbirth. In high-density dog populations, CaHV-1 can also contribute to kennel cough. Furthermore, recent literature has clearly documented that CaHV-1 can induce ocular disease in immature and adult dogs. The current study describes a case of fatal CaHV-1 infection in a 9-year-old spayed female Bichon Frise dog. Following a history of vomiting and diarrhea, the dog deteriorated and subsequently died. The main lesions were multifocal areas of necrosis with intranuclear inclusion bodies in the liver, adrenal gland, and small intestine, similar to the lesions observed in CaHV-1-infected puppies. Infection with CaHV-1 was confirmed on samples of liver by polymerase chain reaction, immunohistochemistry, and in situ hybridization. There was no indication of immunosuppression in this dog. Based on the results presented herein, CaHV-1 should be included in the list of differential diagnoses of hepatic necrosis in adult dogs.
authors.affiliation: Diagnostic Center for Population and Animal Health, Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48910-8104, USA.
authors.forename: Barbie J
authors.initials: BJ
authors.lastname: Gadsden
authors.forename: Roger K
authors.initials: RK
authors.lastname: Maes
authors.forename: Annabel G
authors.initials: AG
authors.lastname: Wise
authors.forename: Matti
authors.initials: M
authors.lastname: Kiupel
authors.forename: Ingeborg M
authors.initials: IM
authors.lastname: Langohr
mesh_terms: D000818:Animals; D004279:DNA, Viral / Q000737:chemistry / Q000235:genetics; D004283:Dog Diseases / Q000473:pathology / Q000821:virology*; D004285:Dogs; D017809:Fatal Outcome; D005260:Female; D006566:Herpesviridae Infections / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D002184:Herpesvirus 1, Canid / Q000235:genetics / Q000302:isolation & purification*; D007150:Immunohistochemistry / Q000662:veterinary; D017403:In Situ Hybridization / Q000662:veterinary; D008107:Liver Diseases / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D016133:Polymerase Chain Reaction / Q000662:veterinary
chemical_list: D004279:DNA, Viral