title: Synthesis of 3-(2, 8, 9-trioxa-5-aza-1-germatricyclo [3.3.3.0] undecane-1-yl)-3-(4-hydroxyl-3-methoxyphenyl)-propionic acid and its inhibitory effect on the cervical tumor U14 in vitro and in vivo.
abstract: In this study, the novel germatrane compound, 3-(2, 8, 9-trioxa-5-aza-1- germatricyclo [3.3.3.0] undecane-1-yl)-3-(4-hydroxy-3- methoxyphenyl)-propionic acid (1), has been synthesized and its activities against cervical tumor U14 were evaluated in vitro and in vivo. The results have demonstrated that the compound posed significant inhibition on U14 tumor with IC(50) values of 48.57 mg/L in cell-based assay and tumor inhibitory rates of 38.50%, 47.17% and 64.02% (from low dose to high dose) in animal experiment.
authors.affiliation: Medicinal Chemistry Department, Guangdong Pharmaceutical University, Guangzhou, Guangdong, China.
authors.forename: Lianbao
authors.initials: L
authors.lastname: Ye
authors.forename: Xiaomin
authors.initials: X
authors.lastname: Ou
authors.forename: Xuedong
authors.initials: X
authors.lastname: Peng
authors.forename: Yan
authors.initials: Y
authors.lastname: Luo
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002109:Caffeic Acids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D005260:Female; D020128:Inhibitory Concentration 50; D051379:Mice; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy*
chemical_list: C576810:3-(2,8,9-trioxa-5-aza-1-germatricyclo(3.3.3.0)undecane-1-yl)-3-(4-hydroxyl-3-methoxyphenyl)propionic acid; D000970:Antineoplastic Agents; D002109:Caffeic Acids; D009942:Organometallic Compounds