title: The effect of diallyl polysulfanes on cellular signaling cascades.
abstract: Diallyl polysulfanes, such as diallyl trisulfide and diallyl tetrasulfide, are regarded as a group of potential chemopreventive compounds as they have been proven to be effective inhibitors of cancer cells. These agents have been implicated in signal transductions, including the generation of Reactive Oxygen Species (ROS), Endoplasmic Reticulum (ER) stress, mitogen-activated protein kinase (MAPK) signaling, regulation of cell cycle progression, and induction of apoptosis. Nonetheless, certain aspects of the diallyl polysulfane triggered inhibitory effects on cancer cells are still not clear. Understanding the targeted signaling pathways may help to develop new strategies to treat cancer and other diseases. This review is therefore aimed at addressing the targeting of specific intracellular signal transduction cascades by these diallyl polysulfanes in order to shed some light on possible mechanisms of action of these compounds.
authors.affiliation: Medizinische Biochemie und Molekularbiologie und Kompetenzzentrum Molekulare Medizin (KOMM), Universität des Saarlandes, Gebäude 44, 66424 Homburg, Germany. Mathias.Montenarh@uks.eu
authors.forename: Mathias
authors.initials: M
authors.lastname: Montenarh
authors.forename: Nathaniel E B
authors.initials: NE
authors.lastname: Saidu
mesh_terms: D000475:Alkenes / Q000737:chemistry / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D002453:Cell Cycle / Q000187:drug effects; D059865:Endoplasmic Reticulum Stress / Q000187:drug effects; D006801:Humans; D020935:MAP Kinase Signaling System / Q000187:drug effects; D017382:Reactive Oxygen Species / Q000737:chemistry; D015398:Signal Transduction / Q000187:drug effects*; D013451:Sulfonic Acids / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000475:Alkenes; D017382:Reactive Oxygen Species; D013451:Sulfonic Acids