title: Cortical thinning in subcortical vascular dementia with negative 11C-PiB PET.
abstract: To determine the existence of cortical thinning in subcortical vascular dementia (SVaD) with a negative 11C-Pittsburgh compound B (PiB) positron emission tomography scan and to compare the topography of cortical thinning between PiB-negative SVaD and Alzheimer's disease (AD), we enrolled 24 patients with PiB(-) SVaD, 81 clinically probable AD individuals, and 72 normal cognitive controls. Compared with controls, cortical thinning in PiB(-) SVaD was most profound in the perisylvian area, medial prefrontal area, and posterior cingulate gyri, while the precuneus and medial temporal lobes were relatively spared. When the cortical thickness of AD and PiB(-) SVaD were directly compared, PiB(-) SVaD demonstrated significant cortical thinning in the bilateral inferior frontal, superior temporal gyri, and right medial frontal and orbitofrontal lobes, while AD showed significant cortical thinning in the right medial temporal region. SVaD without amyloid burden may lead to substantial cortical atrophy. Moreover, characteristic topography of cortical thinning in PiB(-) SVaD suggests different mechanisms of cortical thinning in PiB(-) SVaD and AD.
authors.affiliation: Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Kangnam-ku, Seoul, South Korea.
authors.forename: Chi Hun
authors.initials: CH
authors.lastname: Kim
authors.forename: Sang Won
authors.initials: SW
authors.lastname: Seo
authors.forename: Geon Ha
authors.initials: GH
authors.lastname: Kim
authors.forename: Ji Soo
authors.initials: JS
authors.lastname: Shin
authors.forename: Hanna
authors.initials: H
authors.lastname: Cho
authors.forename: Young
authors.initials: Y
authors.lastname: Noh
authors.forename: Suk-Hui
authors.initials: SH
authors.lastname: Kim
authors.forename: Min Ji
authors.initials: MJ
authors.lastname: Kim
authors.forename: Seun
authors.initials: S
authors.lastname: Jeon
authors.forename: Uicheul
authors.initials: U
authors.lastname: Yoon
authors.forename: Jong-Min
authors.initials: JM
authors.lastname: Lee
authors.forename: Seung Jun
authors.initials: SJ
authors.lastname: Oh
authors.forename: Jae Seung
authors.initials: JS
authors.lastname: Kim
authors.forename: Sung Tae
authors.initials: ST
authors.lastname: Kim
authors.forename: Jae-Hong
authors.initials: JH
authors.lastname: Lee
authors.forename: Duk L
authors.initials: DL
authors.lastname: Na
mesh_terms: D000368:Aged; D000814:Aniline Compounds; D052160:Benzothiazoles; D002250:Carbon Radioisotopes; D002540:Cerebral Cortex / Q000000981:diagnostic imaging* / Q000473:pathology; D015140:Dementia, Vascular / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D049268:Positron-Emission Tomography / Q000379:methods; D016037:Single-Blind Method; D013844:Thiazoles
chemical_list: C475519:2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole; D000814:Aniline Compounds; D052160:Benzothiazoles; D002250:Carbon Radioisotopes; D013844:Thiazoles