title: One-pot, three-component synthesis of a library of spirooxindole-pyrimidines catalyzed by magnetic nanoparticle supported dodecyl benzenesulfonic acid in aqueous media.
abstract: Dodecyl benzenesulfonic acid functionalized silica-coated magnetic nanoparticles (γ-Fe2O3@SiO2-DDBSA) were readily prepared and identified as an efficient catalyst for the synthesis of a library of spirooxindole-pyrimidine derivatives by three-component condensation reaction of barbituric acids, isatins and cyclohexane-1,3-diones. The aqueous reaction medium, easy recovery of the catalyst using an external magnet, and high yields make the protocol sustainable and economic.
authors.affiliation: Key Laboratory of Inorganic Nanomaterial of Hebei Province, College of Chemistry & Material Science, Hebei Normal University , Shijiazhuang 050024, China.
authors.forename: Jia
authors.initials: J
authors.lastname: Deng
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Mo
authors.forename: Fei-Yang
authors.initials: FY
authors.lastname: Zhao
authors.forename: Zhan-Hui
authors.initials: ZH
authors.lastname: Zhang
authors.forename: Shou-Xin
authors.initials: SX
authors.lastname: Liu
mesh_terms: D002384:Catalysis; D008280:Magnetics; D008855:Microscopy, Electron, Scanning; D053758:Nanoparticles / Q000737:chemistry*; D011743:Pyrimidines / Q000138:chemical synthesis*; D014867:Water / Q000737:chemistry*
chemical_list: D011743:Pyrimidines; D014867:Water