title: Assembly of N,N-disubstituted hydrazines and 1-aryl-1H-indazoles via copper-catalyzed coupling reactions.
abstract: CuI-catalyzed coupling of N-acyl-N'-substituted hydrazines with aryl iodides takes place at 60-90 °C to afford N-acyl-N',N'-disubstituted hydrazines regioselectively and thereby gives a facile method for assembling N,N-diaryl hydrazines. N-Acyl-N'-substituted hydrazines can also react with 2-bromoarylcarbonylic compounds at 60-125 °C under the catalysis of CuI/4-hydroxy-l-proline to provide 1-aryl-1H-indazoles.
authors.affiliation: Department of Chemistry, Fudan University , Shanghai 200433, China.
authors.forename: Xiaodong
authors.initials: X
authors.lastname: Xiong
authors.forename: Yongwen
authors.initials: Y
authors.lastname: Jiang
authors.forename: Dawei
authors.initials: D
authors.lastname: Ma
mesh_terms: D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003300:Copper / Q000737:chemistry*; D006834:Hydrazines / Q000138:chemical synthesis* / Q000737:chemistry*; D007191:Indazoles / Q000138:chemical synthesis* / Q000737:chemistry; D007454:Iodides / Q000737:chemistry*; D015394:Molecular Structure; D011392:Proline / Q000031:analogs & derivatives / Q000737:chemistry
chemical_list: D006834:Hydrazines; D007191:Indazoles; D007454:Iodides; D003300:Copper; C073870:cuprous iodide; D011392:Proline