title: Hemodynamic effects of peri-operative statin therapy in on-pump cardiac surgery patients.
abstract: BACKGROUND
  Peri-operative statin therapy in cardiac surgery cases is reported to reduce the rate of mortality, stroke, postoperative atrial fibrillation, and systemic inflammation. Systemic inflammation could affect the hemodynamic parameters and stability. We set out to study the effect of statin therapy on perioperative hemodynamic parameters and its clinical outcome.
  
  
  METHODS
  In a single center study from 2006 to 2007, peri-operative hemodynamic parameters of 478 patients, who underwent cardiac surgery with cardiopulmonary bypass, were measured. Patients were divided into those who received perioperative statin therapy (n = 276; statin group) and those who did not receive statin therapy (n = 202; no-statin group). The two groups were compared together using Kolmogorov-Smirnov-Test, Fisher's-Exact-Test, and Student's-T-test. A p value < 0.05 was considered as significant.
  
  
  RESULTS
  There was no significant difference in the preoperative risk factors. Onset of postoperative atrial fibrillation was not affected by statin therapy. Extended hemodynamic measurements revealed no significant difference between the two groups, apart from Systemic Vascular Resistance Index (SVRI). The no-statin group had a significantly higher SVRI (882 ± 206 vs. 1050 ± 501 dyn s/cm5/m2, p = 0.022). Inotropic support was the same in both groups and no significant difference in the mortality rate was noticed. Also, hemodynamic parameters were not affected by different types and doses of statins.
  
  
  CONCLUSIONS
  Perioperative statin therapy for patients undergoing on-pump coronary bypass grafting or valvular surgery, does not affect the hemodynamic parameters and its clinical outcome.
authors.affiliation: Department of Anaesthesiology, Emergency and Intensive Care Medicine, University of Göttingen, Göttingen, Germany.
authors.forename: Jose
authors.initials: J
authors.lastname: Hinz
authors.forename: Philipp
authors.initials: P
authors.lastname: Gehoff
authors.forename: Hanna
authors.initials: H
authors.lastname: Schotola
authors.forename: Morteza Tavakkoli
authors.initials: MT
authors.lastname: Hosseini
authors.forename: Vassilios N
authors.initials: VN
authors.lastname: Didilis
authors.forename: Ahmad Fawad
authors.initials: AF
authors.lastname: Jebran
authors.forename: Anastasia
authors.initials: A
authors.lastname: Gehoff
authors.forename: Christoph H
authors.initials: CH
authors.lastname: Wiese
authors.forename: Egbert Godehard
authors.initials: EG
authors.lastname: Schulz
authors.forename: Friedrich Albert
authors.initials: FA
authors.lastname: Schoendube
authors.forename: Aron Frederik
authors.initials: AF
authors.lastname: Popov
mesh_terms: D000368:Aged; D006348:Cardiac Surgical Procedures / Q000379:methods*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D019990:Perioperative Care / Q000379:methods; D011292:Premedication; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome
chemical_list: D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors