title: Pilot study on the use of acoustic radiation force impulse imaging in the staging of cystic fibrosis associated liver disease.
abstract: BACKGROUND
  Acoustic radiation force impulse (ARFI) is a novel technique for the measurement of hepatic stiffness, which could be valuable in clinical follow-up of patients affected by cystic fibrosis liver disease (CFLD).
  
  
  METHODS
  Seventy-five patients with suspected CFLD (35 males) underwent clinical and ultrasonographic evaluations, liver and pulmonary function tests, ARFI investigation, and upper gastrointestinal endoscopy. Ten ARFI measurements were taken at the deep right hepatic lobe to compute median values of Shear Wave Velocity (SWV) for each individual.
  
  
  RESULTS
  SWV increased progressively from 1.02m/s (95%, Confidence Interval, CI, 0.92-1.126) in patients with no evidence of CFLD at ultrasonography (N=16), to 1.12 (95%CI 1.049-1.19) in patients with CFLD and no signs of portal hypertension (PHT, N=23), and to 1.25 (95%CI 1.14-1.358) in those with CFLD and signs of PHT (N=28). SWV was 1.63 (95%CI 1.26-1.99) in patients with oesophageal varices (N=8) (p<0.0001).
  
  
  CONCLUSIONS
  ARFI may represent an easy, fast and non-invasive tool for the clinical follow-up of patients with cystic fibrosis associated liver disease.
authors.affiliation: Research Unit for Multifactorial Diseases, Bambino Gesù Children's Hospital, IRCCS, Rome, Italy. melania.manco@opbg.net
authors.forename: Melania
authors.initials: M
authors.lastname: Manco
authors.forename: Cristina Lo
authors.initials: CL
authors.lastname: Zupone
authors.forename: Federico
authors.initials: F
authors.lastname: Alghisi
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: D'Andrea
authors.forename: Vincenzina
authors.initials: V
authors.lastname: Lucidi
authors.forename: Lidia
authors.initials: L
authors.lastname: Monti
mesh_terms: D000293:Adolescent; D000328:Adult; D003550:Cystic Fibrosis / Q000150:complications / Q000503:physiopathology; D054459:Elasticity Imaging Techniques / Q000379:methods*; D016099:Endoscopy, Gastrointestinal; D004932:Esophageal and Gastric Varices / Q000000981:diagnostic imaging* / Q000209:etiology; D005260:Female; D006801:Humans; D006975:Hypertension, Portal / Q000000981:diagnostic imaging* / Q000209:etiology; D008099:Liver / Q000473:pathology; D008107:Liver Diseases / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D008111:Liver Function Tests / Q000379:methods; D008297:Male; D008991:Monitoring, Physiologic / Q000379:methods; D010865:Pilot Projects; D012372:ROC Curve; D015203:Reproducibility of Results; D013016:Sound