title: Polymorphisms of MTHFR C677T and A1298C association with oral carcinoma risk: a meta-analysis.
abstract: Investigations regarding association of MTHFR polymorphisms with oral carcinoma risk have yielded inconclusive results. Thus, meta-analyses were performed. Results showed that no associations of C677T polymorphisms with oral carcinoma were observed for the overall data. In subgroup analyses by drinking status, homozygous TT alleles exhibited elevated oral cancer susceptibility in heavy drinkers. For A1298C polymorphism, CC alleles presented a possible preventive role for oral cancer. Collectively, results suggest that MTHFR 677TT polymorphism might be a low-penetrant risk factor for oral carcinoma only in heavy drinkers. Conversely, 1298CC alleles might play a preventive role for oral cancer.
authors.affiliation: Department of Stomatology, Xinqiao Hospital, Third Military Medical University, Chongqing, China.
authors.forename: Xianlu
authors.initials: X
authors.lastname: Zhuo
authors.forename: Junjun
authors.initials: J
authors.lastname: Ling
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhou
authors.forename: Houyu
authors.initials: H
authors.lastname: Zhao
authors.forename: Yufeng
authors.initials: Y
authors.lastname: Song
authors.forename: Yinghui
authors.initials: Y
authors.lastname: Tan
mesh_terms: D000428:Alcohol Drinking / Q000235:genetics; D020022:Genetic Predisposition to Disease; D006801:Humans; D042965:Methylenetetrahydrofolate Reductase (NADPH2) / Q000235:genetics*; D009062:Mouth Neoplasms / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors
chemical_list: D042965:Methylenetetrahydrofolate Reductase (NADPH2)