title: Two new quaternary protoberberine alkaloids from Corydalis yanhusuo.
abstract: Two new quaternary protoberberine alkaloids, namely corydayanine (1) and yanhusuine (2), were isolated from the tubers of Corydalis yanhusuo. On the basis of extensive chemical and spectroscopic evidences, especially 1D and 2D NMR and HRMS experiments, their structures were elucidated as 5,6-dihydro-3,9-dihydroxy-2,10-dimethoxy-13-methyl-dibenzo[a,g] quinolizinium alkaloid and 5,6-dihydro-12-hydroxy-2,3,9-trimethoxy-13-methyl-dibenzo[a,g] quinolizinium alkaloid, respectively.
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
authors.forename: Qiong
authors.initials: Q
authors.lastname: Zhou
authors.forename: An-Jun
authors.initials: AJ
authors.lastname: Deng
authors.forename: Hai-Lin
authors.initials: HL
authors.lastname: Qin
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D001600:Berberine Alkaloids / Q000737:chemistry / Q000302:isolation & purification*; D031311:Corydalis / Q000737:chemistry*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D035281:Plant Tubers / Q000737:chemistry
chemical_list: D000470:Alkaloids; D001600:Berberine Alkaloids; D004365:Drugs, Chinese Herbal; C573373:corydayanine; C573374:yanhusuine; C009090:protoberberine