title: Heart ablation using a planar rectangular high intensity ultrasound transducer and MRI guidance.
abstract: The aim of this study was to evaluate a flat rectangular (3×10mm(2)) MRI compatible transducer operating at 5MHz. The main task was to explore the feasibility of creating deep lesions in heart at a depth of at least 15mm. The size of thermal necrosis in heart tissue was estimated as a function of power and time using a simulation model. The system was then tested in an excised lamb heart. In this study, we were able to create lesions of 15mm deep with acoustic power of 6W for an exposure of approximately 1min. The contrast to noise ratio (CNR) between lesion and heart tissue was evaluated using fast spin echo (FSE). The CNR value was approximately 22 using T1W FSE. Maximum CNR was achieved with repetition time (TR) between 300 and 800ms. Using T2W FSE, the corresponding CNR was approximately 13 for the 14 in vivo experiments. The average lesion depth was 11.93mm with a standard deviation of 0.62mm. In vivo irradiation conditions were 6W for 60s. The size of the lesion in the other two dimensions was close to 3×10mm(2) (size of the transducer element).
authors.affiliation: City University, London, UK. acouppis@cytanet.com.cy
authors.forename: Andreas
authors.initials: A
authors.lastname: Couppis
authors.forename: Christakis
authors.initials: C
authors.lastname: Damianou
authors.forename: Panayiotis
authors.initials: P
authors.lastname: Kyriacou
authors.forename: Cyril
authors.initials: C
authors.lastname: Lafon
authors.forename: Francoise
authors.initials: F
authors.lastname: Chavrier
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Chapelon
authors.forename: Alain
authors.initials: A
authors.lastname: Birer
mesh_terms: D055011:Ablation Techniques / Q000295:instrumentation / Q000379:methods*; D000818:Animals; D006348:Cardiac Surgical Procedures / Q000295:instrumentation / Q000379:methods*; D003198:Computer Simulation; D004867:Equipment Design; D005240:Feasibility Studies; D006321:Heart; D006979:Hyperthermia, Induced / Q000295:instrumentation / Q000379:methods*; D053783:Magnetic Resonance Imaging, Interventional / Q000295:instrumentation*; D011817:Rabbits; D012756:Sheep; D014159:Transducers; D014464:Ultrasonic Therapy / Q000295:instrumentation / Q000379:methods*