title: A delta-sarcoglycan gene polymorphism as a risk factor for hypertrophic cardiomyopathy.
abstract: BACKGROUND
  The C allele of c.-94C>G polymorphism of the delta-sarcoglycan gene was associated as a risk factor for coronary spasm in Japanese patients with hypertrophic cardiomyopathy (HCM).
  
  
  OBJECTIVE
  We evaluated whether the c.-94C>G polymorphism can be a risk factor for HCM in Mexican patients.
  
  
  METHODS
  The polymorphism was genotyped and the risk was estimated in 35 HCM patients and 145 healthy unrelated individuals. Data of this polymorphism reported in Mexican Amerindian populations were included.
  
  
  RESULTS
  The C allele frequency in HCM patients was higher with an odds ratio (OR) of 2.37, and the risk for the CC genotype increased to 5.0. The analysis with Mexican Amerindian populations showed that the C allele frequency was significantly higher in HCM patients with an OR of 2.96 and for CC genotype the risk increased to 7.60.
  
  
  CONCLUSIONS
  The C allele of the c.-94C>G polymorphism is a risk factor for HCM, which is increased by the Amerindian component and can play an important role in the etiology and progression of disease in Mexican patients.
authors.affiliation: Unidad de Investigación Médica en Genética Humana, Hospital de Pediatría, Centro Médico Nacional Siglo XXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico. romaorr@yahoo.com.mx
authors.forename: Rosa M
authors.initials: RM
authors.lastname: Ordoñez-Razo
authors.forename: Martín H
authors.initials: MH
authors.lastname: Garrido-Garduño
authors.forename: Ramón A
authors.initials: RA
authors.lastname: Pérez-Martínez
authors.forename: Victor M
authors.initials: VM
authors.lastname: Ruiz
authors.forename: Esteban
authors.initials: E
authors.lastname: Herrera-Tepatlán
authors.forename: Maricela
authors.initials: M
authors.lastname: Rodríguez-Cruz
authors.forename: Ana L
authors.initials: AL
authors.lastname: Jiménez-Vaca
authors.forename: Fernando
authors.initials: F
authors.lastname: Minauro-Sanmiguel
authors.forename: Fabio A
authors.initials: FA
authors.lastname: Salamanca-Gómez
mesh_terms: D000328:Adult; D002312:Cardiomyopathy, Hypertrophic / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D009154:Mutation; D012307:Risk Factors; D049031:Sarcoglycans / Q000235:genetics*
chemical_list: D049031:Sarcoglycans