title: Pharmacogenetics of glutamate system genes and SSRI-associated sexual dysfunction.
abstract: We examined whether polymorphisms in the GRIK2, GRIA3 and GRIA1 genes were associated with selective serotonin reuptake inhibitor (SSRI)-associated sexual dysfunction in 114 participants treated for depression. One polymorphism in GRIA1 (rs1994862) was associated with arousal dysfunction, providing further evidence for the role of GRIA1 in mechanisms underlying SSRI-associated sexual side effects.
authors.affiliation: University of Illinois at Chicago College of Pharmacy, Department of Pharmacy Practice, Chicago, IL, USA. jbishop@uic.edu
authors.forename: Jeffrey R
authors.initials: JR
authors.lastname: Bishop
authors.forename: Sharon S
authors.initials: SS
authors.lastname: Chae
authors.forename: Shitalben
authors.initials: S
authors.lastname: Patel
authors.forename: Jessica
authors.initials: J
authors.lastname: Moline
authors.forename: Vicki L
authors.initials: VL
authors.lastname: Ellingrod
mesh_terms: D000293:Adolescent; D000328:Adult; D003863:Depression / Q000150:complications / Q000188:drug therapy / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D018091:Receptors, AMPA / Q000235:genetics*; D018092:Kainic Acid Receptors / Q000235:genetics*; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D020018:Sexual Dysfunctions, Psychological / Q000139:chemically induced / Q000150:complications / Q000235:genetics*; D000097806:GluK2 Kainate Receptor
chemical_list: D018091:Receptors, AMPA; D018092:Kainic Acid Receptors; D017367:Selective Serotonin Reuptake Inhibitors; D000097806:GluK2 Kainate Receptor; C104723:glutamate receptor ionotropic, AMPA 3