title: Investigating the recrystallization behavior of amorphous paracetamol by variable temperature Raman studies and surface Raman mapping.
abstract: In situ Raman spectroscopy and Raman mapping are used to monitor the crystallization of amorphous paracetamol in both covered and uncovered geometries, for which different crystallization pathways have been reported previously. The results suggest that surface crystallization predominates in the uncovered samples, leading to forms I and II, whereas in the covered samples bulk crystallization dominates and leads to form III.
authors.affiliation: Laboratory of Biophysics and Surface Analysis, School of Pharmacy, Boots Science Building, University of Nottingham, Nottingham, UK.
authors.forename: Jagadeesh Babu
authors.initials: JB
authors.lastname: Nanubolu
authors.forename: Jonathan C
authors.initials: JC
authors.lastname: Burley
mesh_terms: D000082:Acetaminophen / Q000737:chemistry*; D003460:Crystallization; D025341:Principal Component Analysis; D013059:Spectrum Analysis, Raman / Q000379:methods*; D013696:Temperature
chemical_list: D000082:Acetaminophen