title: [Intended pharmacotherapeutical approaches of Alzheimer's disease therapy].
abstract: Alzheimer's disease is a progressive neurodegenerative disorder mainly manifested by memory loss, personality changes, and cognitive dysfunction. Despite the fact that tireless research is being conducted, up-to-date pharmacotherapy of AD is presented only by two groups diverging in the mechanism of action. The larger one uses acetylcholinesterase inhibitors, and the second group is represented by the N-methyl-D-aspartate antagonist memantine. Even though the etiology of Alzheimer's disease is unknown, several different therapeutic approaches are being investigated. The aim of this paper is to provide an overview of the present state of intended therapeutics for AD, describing their mechanism of action if known, displaying chemical structures, and the state of clinical trials if any.
authors.affiliation: Univerzita Karlova v Praze, Farmaceutická fakulta v Hradci Králové, Katedra farmaceutické chemie a kontroly léciv.
authors.forename: Jan
authors.initials: J
authors.lastname: Korábecný
authors.forename: Eva
authors.initials: E
authors.lastname: Hrubá
authors.forename: Ondrej
authors.initials: O
authors.lastname: Soukup
authors.forename: Filip
authors.initials: F
authors.lastname: Zemek
authors.forename: Kamil
authors.initials: K
authors.lastname: Musílek
authors.forename: Eugenie
authors.initials: E
authors.lastname: Nepovímová
authors.forename: Katarína
authors.initials: K
authors.lastname: Spilovská
authors.forename: Veronika
authors.initials: V
authors.lastname: Opletalová
authors.forename: Kamil
authors.initials: K
authors.lastname: Kuca
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy*; D002800:Cholinesterase Inhibitors / Q000627:therapeutic use; D006801:Humans; D008559:Memantine / Q000627:therapeutic use; D016202:N-Methylaspartate / Q000037:antagonists & inhibitors
chemical_list: D002800:Cholinesterase Inhibitors; D016202:N-Methylaspartate; D008559:Memantine