title: Efficacy and Tolerability of Malartin and Sulphadoxine-Pyrimethamine Combination against Uncomplicated Falciparum Malaria in Dibanda, Southwest Cameroon.
abstract: Artemisinin derivatives are now the most potent and rapidly acting antimalarials. The aim of this study was to assess the in vivo efficacy and tolerability of a combination of Malartin (an artesunate) and sulphadoxine-pyrimethamine (SP) in the treatment of uncomplicated falciparum malaria in Dibanda, Cameroon. A total of 197 subjects were recruited into the study and administered Malartin for 3 days and SP as a single dose on day 0. Only 174 of the subjects were successfully followed up on days 3, 7, and 14. The overall success rate of the drug combination was 92.53%. Parasite density decreased during the follow-up period in different age groups, sexes, and social classes. The prevalence of anaemia decreased from 22.99% at enrolment to 9.77% on day 14, and the difference was significant (P < 0.05) on all days of followup. The drug combination did not give rise to any serious side effects.
authors.affiliation: Department of Plant and Animal Sciences, Faculty of Science, University of Buea, P.O. Box 63, Buea, SWR, Cameroon.
authors.forename: Helen Kuokuo
authors.initials: HK
authors.lastname: Kimbi
authors.forename: Mesame
authors.initials: M
authors.lastname: Ntoko
authors.forename: Nelson N
authors.initials: NN
authors.lastname: Ntonifor
authors.forename: Emmaculate
authors.initials: E
authors.lastname: Lum
authors.forename: Anna L
authors.initials: AL
authors.lastname: Njunda
authors.forename: Peter Nde
authors.initials: PN
authors.lastname: Fon