title: [NGAL, biomarker of acute kidney injury in 2012].
abstract: Neutrophil Gelatinase Associated Lipocalin (NGAL) is one of the most promising biomarkers for acute kidney injury (AKI). Although urinary NGAL is intuitively more appropriate to apprehend renal injury, clinical data have accumulated on the potential interest of NGAL measured indifferently in serum or urine. Diagnostic performance of NGAL greatly varies across studies according to different factors such as the type of patients (pediatric versus adult) and the clinical situations (surgery versus intensive care). Overall, NGAL is presented as a useful tool to diagnose and predict AKI outcome but several issues (the absence of a unique pertinent threshold value, the incomplete analytical validation of its measurement and, its apparent limited clinical added value as compared to traditional AKI markers) remain to be addressed in order to definitely recommend its use in clinical practice.
authors.affiliation: Service de néphrologie, dialyse, hypertension, transplantation, université Jean Monnet, hopital Nord, CHU de Saint-Étienne, 42055 Saint-Étienne cedex 2, France. amandinebrunon@yahoo.fr
authors.forename: Amandine
authors.initials: A
authors.lastname: Gagneux-Brunon
authors.forename: Pierre
authors.initials: P
authors.lastname: Delanaye
authors.forename: Delphine
authors.initials: D
authors.lastname: Legrand
authors.forename: Etienne
authors.initials: E
authors.lastname: Cavalier
authors.forename: Christophe
authors.initials: C
authors.lastname: Mariat
mesh_terms: D058186:Acute Kidney Injury / Q000145:classification / Q000175:diagnosis*; D000209:Acute-Phase Proteins / Q000032:analysis* / Q000502:physiology; D015415:Biomarkers / Q000032:analysis; D042241:Early Diagnosis; D006801:Humans; D016030:Kidney Transplantation; D000071068:Lipocalin-2; D054834:Lipocalins / Q000032:analysis* / Q000502:physiology; D011379:Prognosis; D011518:Proto-Oncogene Proteins / Q000032:analysis* / Q000502:physiology
chemical_list: D000209:Acute-Phase Proteins; D015415:Biomarkers; C489506:LCN2 protein, human; D000071068:Lipocalin-2; D054834:Lipocalins; D011518:Proto-Oncogene Proteins