title: Sprint interval running increases insulin sensitivity in young healthy subjects.
abstract: High intensity cycling training increases oxidative capacity in skeletal muscles and improves insulin sensitivity. The present study compared the effect of eight weeks of sprint interval running (SIT) and continuous running at moderate intensity (CT) on insulin sensitivity and cholesterol profile in young healthy subjects (age 25.2 ± 0.7; VO(2max) 49.3 ± 1.2 ml·kg(-1)·min(-1)). SIT and CT increased maximal oxygen uptake by 5.3 ± 1.8 and 3.8 ± 1.6%, respectively (p < 0.05 for both). Oral glucose tolerance test (OGTT) was performed before and 60 h after the last training session. SIT, but not CT, reduced glucose area under curve and improved HOMA β-cell index (p < 0.05). Insulin area under curve did not decrease significantly in any group. SIT, but not CT, reduced LDL and total cholesterol. In conclusion, sprint interval running improves insulin sensitivity and cholesterol profile in healthy subjects, and sprint interval running may be more effective to improve insulin sensitivity than continuous running at moderate intensity.
authors.affiliation: Department of Physical Performance, Norwegian School of Sport Science, PO Box 4014 Ullevål Stadion, N-0806 Oslo, Norway.
authors.forename: Marit
authors.initials: M
authors.lastname: Sandvei
authors.forename: Per Bendix
authors.initials: PB
authors.lastname: Jeppesen
authors.forename: Line
authors.initials: L
authors.lastname: Støen
authors.forename: Sigbjørn
authors.initials: S
authors.lastname: Litleskare
authors.forename: Egil
authors.initials: E
authors.lastname: Johansen
authors.forename: Trine
authors.initials: T
authors.lastname: Stensrud
authors.forename: Eystein
authors.initials: E
authors.lastname: Enoksen
authors.forename: Arto
authors.initials: A
authors.lastname: Hautala
authors.forename: Kaisu
authors.initials: K
authors.lastname: Martinmäki
authors.forename: Hannu
authors.initials: H
authors.lastname: Kinnunen
authors.forename: Mikko
authors.initials: M
authors.lastname: Tulppo
authors.forename: Jørgen
authors.initials: J
authors.lastname: Jensen
mesh_terms: D000293:Adolescent; D000328:Adult; D019540:Area Under Curve; D001786:Blood Glucose / Q000032:analysis; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D018482:Muscle, Skeletal / Q000502:physiology; D010101:Oxygen Consumption; D010807:Physical Endurance / Q000502:physiology*; D012420:Running / Q000145:classification / Q000502:physiology*
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D007328:Insulin