title: Fast-spiking interneurons and gamma oscillations may be involved in the antidepressant effects of ketamine.
abstract: Accumulating lines of evidence have indicated that a non-selective N-methyl-d-aspartate (NMDA) receptor antagonist ketamine exerts fast and robust antidepressant effects via stimulating glutamate transmission and activating the glutamate alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors. Moreover, NMDA receptor antagonist has the ability to reduce the activity of fast-spiking (FS) interneurons which results in the disinhibition of pyramidal neurons and increases the glutamate transmission. We therefore hypothesize that FS interneurons may play an important role in the antidepressant effects of ketamine. Quantification of FS interneurons function via analyzing gamma oscillations may guide the antidepressant therapy of ketamine in clinical practice.
authors.affiliation: Department of Anesthesiology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, PR China.
authors.forename: Zhi-qiang
authors.initials: ZQ
authors.lastname: Zhou
authors.forename: Guang-fen
authors.initials: GF
authors.lastname: Zhang
authors.forename: Xiao-min
authors.initials: XM
authors.lastname: Li
authors.forename: Chun
authors.initials: C
authors.lastname: Yang
authors.forename: Jian-jun
authors.initials: JJ
authors.lastname: Yang
mesh_terms: D000200:Action Potentials; D000928:Antidepressive Agents / Q000494:pharmacology*; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D006801:Humans; D007395:Interneurons / Q000502:physiology*; D007649:Ketamine / Q000494:pharmacology*; D008962:Models, Theoretical
chemical_list: D000928:Antidepressive Agents; D018691:Excitatory Amino Acid Antagonists; D007649:Ketamine