title: Studies on synthesis, characterization, DNA interaction and cytotoxicity of ruthenium(II) Schiff base complexes.
abstract: The synthesis and characterization of three hexa-coordinated ruthenium(II) Schiff base complexes of the type [RuCl(CO)(B)L] (B=PPh(3)/AsPh(3)/py and L=monobasic tridentate Schiff base ligand derived by the condensation of salicylaldehyde with 4-aminoantipyrine) are reported. IR, electronic, NMR and mass spectral data of the complexes are discussed. An octahedral geometry has been tentatively proposed for all the complexes. DNA binding properties of the ligand and its ruthenium(II) complexes have been investigated by electronic absorption spectroscopy. Two of the complexes were tested for DNA cleavage property. Finally, in vitro study of the cytotoxicity of the ligand and the complex [RuCl(CO)(PPh(3))L] on HeLa were tested. The IC(50) value for the ligand and the complex were 52.3 and 31.6μm respectively.
authors.affiliation: Department of Chemistry, Sri Ramakrishna Mission Vidyalaya College of Arts and Science, Coimbatore 641 020, Tamil Nadu, India.
authors.forename: Gunasekaran
authors.initials: G
authors.lastname: Raja
authors.forename: Ray J
authors.initials: RJ
authors.lastname: Butcher
authors.forename: Chinnasamy
authors.initials: C
authors.lastname: Jayabalakrishnan
mesh_terms: D000042:Absorption / Q000187:drug effects; D000818:Animals; D002417:Cattle; D016923:Cell Death / Q000187:drug effects; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000633:toxicity*; D018360:Crystallography, X-Ray; D004247:DNA / Q000378:metabolism*; D053837:DNA Cleavage / Q000187:drug effects; D004583:Electrons; D006367:HeLa Cells; D006801:Humans; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008968:Molecular Conformation; D012428:Ruthenium / Q000378:metabolism* / Q000633:toxicity*; D012545:Schiff Bases / Q000138:chemical synthesis* / Q000378:metabolism / Q000633:toxicity*; D013055:Spectrophotometry, Infrared
chemical_list: D056831:Coordination Complexes; D008024:Ligands; D012545:Schiff Bases; D012428:Ruthenium; D004247:DNA; C427203:calf thymus DNA