title: A single-centre randomized controlled clinical trial on the adjunct treatment of intra-bony defects with autogenous bone or a xenograft: results after 12 months.
abstract: BACKGROUND
  Limited evidence exists on the efficacy of regenerative treatment of peri-implantitis.
  
  
  METHODS
  Subjects receiving antibiotics and surgical debridement were randomly assigned to placement of autogenous bone (AB) or bovine-derived xenograft (BDX) and with placement of a collagen membrane. The primary outcome was evidence of radiographic bone fill and the secondary outcomes included reductions of probing depth (PD) bleeding on probing (BOP) and suppuration.
  
  
  RESULTS
  Twenty-two subjects were included in the AB and 23 subjects in the BDX group. Statistical analysis failed to demonstrate differences for 38/39 variables assessed at baseline. At 12 months, significant better results were obtained in the BDX group for bone levels (p < 0.001), BOP (p = 0.004), PI (p = 0.003) and suppuration (p < 0.01). When adjusting for number of implants treated per subject, a successful treatment outcome PD ≤ 5.0 mm, no pus, no bone loss and BOP at 1/4 or less sites the likelihood of defect fill was higher in the BDX group (LR: 3.2, 95% CI: 1.0-10.6, p < 0.05).
  
  
  CONCLUSIONS
  Bovine xenograft provided more radiographic bone fill than AB. The success for both surgical regenerative procedures was limited. Decreases in PD, BOP, and suppuration were observed.
authors.affiliation: Uppsala Käkkirurgiska Centrum, Uppsala, Sweden.
authors.forename: Ahmad
authors.initials: A
authors.lastname: Aghazadeh
authors.forename: G
authors.initials: G
authors.lastname: Rutger Persson
authors.forename: Stefan
authors.initials: S
authors.lastname: Renvert
mesh_terms: D020341:Absorbable Implants; D000368:Aged; D000539:Alveolar Process / Q000000981:diagnostic imaging; D000818:Animals; D001861:Bone Regeneration / Q000502:physiology; D018786:Bone Substitutes / Q000627:therapeutic use; D016025:Bone Transplantation / Q000379:methods*; D002417:Cattle; D003094:Collagen; D003774:Dental Plaque Index; D005260:Female; D005500:Follow-Up Studies; D005884:Gingival Hemorrhage / Q000601:surgery; D005889:Gingival Recession / Q000601:surgery; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008567:Membranes, Artificial; D008903:Minerals / Q000627:therapeutic use; D057873:Peri-Implantitis / Q000000981:diagnostic imaging / Q000601:surgery*; D010514:Periodontal Pocket / Q000601:surgery; D011446:Prospective Studies; D011859:Radiography; D016037:Single-Blind Method; D013492:Suppuration; D014182:Transplantation, Autologous; D014183:Transplantation, Heterologous; D016896:Treatment Outcome
chemical_list: C077540:Bio-Oss; D018786:Bone Substitutes; D008567:Membranes, Artificial; D008903:Minerals; D003094:Collagen