title: Is thrombophilia a risk factor for placenta-mediated pregnancy complications?
abstract: OBJECTIVE
  To determine if thrombophilia is a risk factor for placenta-mediated pregnancy complications (PMPC) (i.e., preeclampsia, intrauterine growth restriction (IUGR), placental abruption, intrauterine fetal death and recurrent pregnancy loss).
  
  
  METHODS
  A 5-year retrospective cohort study. Ongoing pregnancies in women with an antecedent PMPC with thrombophilia were compared with the pregnancies in similar women without thrombophilia. The main outcome measures were mean birth weight deviations, corrected for gestational age, and recurrence of PMPC. Low-molecular-weight heparin (LMWH) was employed for thromboprophylaxis only. Mann-Whitney's, Fisher's and Chi-square tests were employed for comparison.
  
  
  RESULTS
  PMPC recurred in 10/43 (23 %) in the thrombophilia group and in 7/41 (17 %) in the non-thrombophilia group, P < 0.059. The mean birth weight deviations were not significantly different either: -7.2 versus -3.0 %, respectively. LMWH, as could be expected, was used more often in thrombophilia patients (39/43 vs. 10/41, P < 0.001).
  
  
  CONCLUSIONS
  Thrombophilia does hardly increase the risk of IUGR/PMPC or if so, it can be prevented by LMWH.
authors.affiliation: Department of Obstetrics and Gynecology, Roskilde University Hospital, 4000, Roskilde, Denmark. elisehoffmann@gmail.com
authors.forename: Elise
authors.initials: E
authors.lastname: Hoffmann
authors.forename: Elisabeth
authors.initials: E
authors.lastname: Hedlund
authors.forename: Trine
authors.initials: T
authors.lastname: Perin
authors.forename: Jens
authors.initials: J
authors.lastname: Lyndrup
mesh_terms: D000328:Adult; D001724:Birth Weight; D003718:Denmark / Q000453:epidemiology; D005260:Female; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use; D006801:Humans; D010922:Placenta Diseases / Q000453:epidemiology* / Q000209:etiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology* / Q000209:etiology; D012189:Retrospective Studies; D012307:Risk Factors; D019851:Thrombophilia / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology*
chemical_list: D006495:Heparin, Low-Molecular-Weight