title: Hormone supplementation during aging: how much and when?
abstract: Circulating levels of dehydroepiandrosterone, a major adrenal steroid, show a marked age-related decrease in both humans and nonhuman primates. Because this decrease has been implicated in age-related cognitive decline, we administered supplementary dehydroepiandrosterone to perimenopausal rhesus macaques (Macaca mulatta) to test for cognitive benefits. Although recognition memory improved, there was no benefit to spatial working memory. To address the limitations of this study we developed a hormone supplementation regimen in aged male macaques that more accurately replicates the 24-hr androgen profiles of young animals. We hypothesize that this more comprehensive physiological hormone replacement paradigm will enhance cognitive function in the elderly.
authors.affiliation: Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, Oregon 97006, USA.
authors.forename: K G
authors.initials: KG
authors.lastname: Sorwell
authors.forename: J
authors.initials: J
authors.lastname: Garten
authors.forename: L
authors.initials: L
authors.lastname: Renner
authors.forename: A
authors.initials: A
authors.lastname: Weiss
authors.forename: V T
authors.initials: VT
authors.lastname: Garyfallou
authors.forename: S G
authors.initials: SG
authors.lastname: Kohama
authors.forename: M
authors.initials: M
authors.lastname: Neuringer
authors.forename: H F
authors.initials: HF
authors.lastname: Urbanski
mesh_terms: D000375:Aging; D000728:Androgens / Q000378:metabolism; D000818:Animals; D003071:Cognition / Q000187:drug effects; D003072:Cognition Disorders / Q000188:drug therapy; D003687:Dehydroepiandrosterone / Q000627:therapeutic use*; D006728:Hormones / Q000627:therapeutic use*; D008253:Macaca mulatta; D008297:Male; D008569:Memory Disorders / Q000188:drug therapy; D008570:Memory, Short-Term / Q000187:drug effects; D013256:Steroids / Q000627:therapeutic use*; D013739:Testosterone / Q000627:therapeutic use
chemical_list: D000728:Androgens; D006728:Hormones; D013256:Steroids; D013739:Testosterone; D003687:Dehydroepiandrosterone