title: The relationship between helicobacter pylori infection and gastro-esophageal reflux disease.
abstract: BACKGROUND
  Gastro-esophageal reflux disease is a common condition, affecting 25%-40% of the population. Increasing attention has been paid to the relationship between Helicobacter pylori infection and reflux esophagitis.
  
  
  OBJECTIVE
  The aim of this study was to investigate the association between CagA+ H. pylori and endoscopically proven gastro-esophageal reflux disease.
  
  
  METHODS
  The study group included 60 hospital patients with gastro-esophageal reflux disease between 2007 and 2009 as compared with 30 healthy patients from a control group that was age and sex matched. Helicobacter pylori CagA+ was identified by an immunological test (Immunochromatography test) (ACON, USA).
  
  
  RESULTS
  Helicobacter pyloriCagA+ was present in 42/60 (70%) of the patients with gastro-esophageal reflux disease and in 11/30 (36.6%) patients in the control group (p=0.002). The Odds ratio = 0.8004 with 95% Confidence Interval = from 0.3188 to 2.0094. The relative risk=1.35 that indicates an association between Helicobacter pylori and disease.
  
  
  CONCLUSIONS
  The presence of Helicobacter pylori is significantly increased in patients with gastro-esophageal reflux disease as compared with the control group.
authors.affiliation: Department of Microbiology, Al-Kindi College of Medicine Baghdad University, AL-Nahda Square, Baghdad, Iraq.
authors.forename: Batool M
authors.initials: BM
authors.lastname: Mahdi