title: Serum anti-Mullerian hormone levels correlate with ovarian response in idiopathic hypogonadotropic hypogonadism.
abstract: OBJECTIVE
  The role of serum AMH levels in prediction of ovarian response in idiopathic hypogonadotropic hypogonadism (IHH) was evaluated. MATERIAL METHOD(S): Twelve patients with IHH underwent controlled ovarian hyperstimulation (COH) for IVF were enrolled in this prospective study. Serum AMH levels were studied on the 2nd or 3rd day of an induced menstrual cycle by a preceding low-dose oral contraceptive pill treatment. A fixed dose (150-300 IU/day) of hMG was given in all COH cycles. Correlations between serum AMH levels, COH outcomes and embryological data were investigated.
  
  
  RESULTS
  Mean serum AMH levels was 3.47 ± 2.15 ng/mL and mean serum peak estradiol was 2196 ± 1705 pg/mL. Mean number of follicles >14 mm, >17 mm on hCG day and MII oocytes were 4.14 ± 3.2, 4 ± 2.5 and 7.28 ± 3.5, respectively. Mean number of grade A embryos and transferred embryos were 3.28 ± 2.4 and 2.5 ± 0.7, respectively. The clinical pregnancy rate per patient was 41.6 % (5/12). Positive correlations were observed between serum AMH levels and MII oocytes (r = 0.84), grade A embryos (r = 0.85), serum peak estradiol levels (r = 0.87), and number of follicles >14 mm (r = 0.83) and >17 mm (r = 0.81) on hCG day, respectively.
  
  
  CONCLUSIONS
  AMH appears as a promising marker of ovarian response in patients with IHH undergoing IVF.
authors.affiliation: Department of Obstetrics and Gynecology, Ankara University School of Medicine, Kadın Hastalıkları ve Dog AD, Cebeci, 06100, Ankara, Turkey. msonmezer@gmail.com
authors.forename: M
authors.initials: M
authors.lastname: Sönmezer
authors.forename: B
authors.initials: B
authors.lastname: Özmen
authors.forename: C S
authors.initials: CS
authors.lastname: Atabekoglu
authors.forename: E G
authors.initials: EG
authors.lastname: Papuccu
authors.forename: S
authors.initials: S
authors.lastname: Ozkavukcu
authors.forename: B
authors.initials: B
authors.lastname: Berker
authors.forename: R
authors.initials: R
authors.lastname: Pabuccu
mesh_terms: D000328:Adult; D054304:Anti-Mullerian Hormone / Q000097:blood*; D005260:Female; D005307:Fertilization in Vitro; D006062:Gonadotropins / Q000097:blood; D006801:Humans; D007006:Hypogonadism / Q000097:blood / Q000503:physiopathology; D006080:Ovarian Follicle / Q000502:physiology; D010053:Ovary; D010062:Ovulation Induction; D011247:Pregnancy; D011446:Prospective Studies
chemical_list: D006062:Gonadotropins; D054304:Anti-Mullerian Hormone