title: Management of ovarian and testicular sex cord-stromal tumors in children and adolescents.
abstract: Pediatric ovarian and testicular sex cord-stromal tumors are distinct from germ cell neoplasms and may present with palpable mass or signs of hormone production. Both may be associated with specific genetic syndromes. Staging for ovarian sex cord-stromal tumors is based on the International Federation of Gynecology and Obstetrics classification for ovarian carcinoma. Treatment for those with high risk disease includes multiagent chemotherapy. Testicular stromal tumors often, though not always, follow a benign course. Additional research will help to define optimal treatment strategies for children with these rare tumors.
authors.affiliation: Pediatric Hematology/Oncology, Children's Hospitals and Clinics of Minnesota, Minneapolis, MN 55404, USA. krisann.schultz@childrensmn.org
authors.forename: Kris Ann P
authors.initials: KA
authors.lastname: Schultz
authors.forename: Dominik T
authors.initials: DT
authors.lastname: Schneider
authors.forename: Farzana
authors.initials: F
authors.lastname: Pashankar
authors.forename: Jonathan
authors.initials: J
authors.lastname: Ross
authors.forename: Lindsay
authors.initials: L
authors.lastname: Frazier
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy*; D012307:Risk Factors; D018312:Sex Cord-Gonadal Stromal Tumors / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy*; D013736:Testicular Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy*