title: Etravirine concentrations in the cervicovaginal compartment in HIV-1-infected women receiving etravirine-containing antiretroviral therapy: DIVA 02 study.
abstract: We studied the penetration of etravirine and HIV shedding in the genital tract among 12 HIV-1-infected women receiving an etravirine-containing regimen who had <40 copies/ml blood plasma (BP) HIV RNA. None of the cervicovaginal fluid (CVF) samples showed detectable HIV RNA. Median etravirine concentrations were 663 ng/ml in BP and 857 ng/ml in CVF, with a CVF/BP etravirine ratio of approximately 1.2. This good penetration of etravirine may contribute to the control of viral replication in the female genital tract.
authors.affiliation: LC Fleming Hospital, Infectious Diseases, Saint Martin, French West Indies. drcyrilclavel@yahoo.fr
authors.forename: C
authors.initials: C
authors.lastname: Clavel
authors.forename: G
authors.initials: G
authors.lastname: Peytavin
authors.forename: R
authors.initials: R
authors.lastname: Tubiana
authors.forename: C
authors.initials: C
authors.lastname: Soulié
authors.forename: E
authors.initials: E
authors.lastname: Courbon
authors.forename: C
authors.initials: C
authors.lastname: Crenn-Hebert
authors.forename: H
authors.initials: H
authors.lastname: Ichou
authors.forename: C
authors.initials: C
authors.lastname: Blanc
authors.forename: L
authors.initials: L
authors.lastname: Schneider
authors.forename: C
authors.initials: C
authors.lastname: Katlama
authors.forename: A-G
authors.initials: AG
authors.lastname: Marcelin
authors.forename: L
authors.initials: L
authors.lastname: Mandelbrot
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D002584:Cervix Uteri / Q000378:metabolism*; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D009570:Nitriles; D011724:Pyridazines / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D011743:Pyrimidines; D012367:RNA, Viral / Q000097:blood / Q000235:genetics; D014621:Vagina / Q000378:metabolism*; D014779:Virus Replication / Q000187:drug effects
chemical_list: D019380:Anti-HIV Agents; D009570:Nitriles; D011724:Pyridazines; D011743:Pyrimidines; D012367:RNA, Viral; C451734:etravirine