title: [The pathogenic aspects of fat acids metabolism with short chain and production of cytokines in target affected areas of skin under psoriasis].
abstract: The article deals with the results of analysis of specters of short-chained fat acids and cytokines in affected skin of patients with psoriasis. The study revealed the significant decrease of short-chained fat acids level, the shift of cytokine profile in the direction of anti-inflammatory factors (interleukins 1L-1beta, IL-8, tumor necrosis factor TNF-alpha, interferon IFN-alpha) and mytogenetic factors (EGF) on the background of stable values of anti-inflammatory cytokine IL-4. The direct pathogenically significant correlation relationships are established between the IL-4 level and the amount of most analyzed short-chained fat acids. The negative correlation relationships were established between content of C2 and IL-1beta.
authors.forename: E V
authors.initials: EV
authors.lastname: fal'ko
authors.forename: B S
authors.initials: BS
authors.lastname: Khyshiktuev
authors.forename: T M
authors.initials: TM
authors.lastname: Karavaeva
authors.forename: P P
authors.initials: PP
authors.lastname: Tereshkov
authors.forename: A Ts
authors.initials: ATs
authors.lastname: Gomboeva
mesh_terms: D000293:Adolescent; D000328:Adult; D016207:Cytokines / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism*; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000378:metabolism* / Q000473:pathology; D012867:Skin / Q000378:metabolism* / Q000473:pathology
chemical_list: D016207:Cytokines; D005227:Fatty Acids