title: [Cardiovascular risk in human immunodeficiency virus-infected patients in Spain. CoRIS cohort, 2011].
abstract: BACKGROUND
  Current information on cardiovascular risk (CVR) in HIV-infected patients in Spain is limited.
  
  
  METHODS
  An analysis was made of a prospective multicentre cohort of Spanish HIV-infected patients (CoRIS) between January-2010 and July-2011. CVR was evaluated using Framingham, REGICOR and SCORE equations.
  
  
  RESULTS
  The study included 1019 patients (76% males, mean age 40 years) recruited from 13 hospitals belonging to 10 autonomous communities in Spain. Almost two-thirds (65.4%) of patients were on antiretroviral therapy (ART), 36.7% with non-nucleoside analogs, 24% with protease inhibitors (PIs) (52% with atazanavir/r or darunavir/r) and 4,6% with raltegravir. More than half (56.2%) of the patients had an HIV viral load <50 copies/ml. Smoking prevalence was 46%, HDL cholesterol (HDL-C) <40mg/dl 36.1%, total cholesterol (total-C) >200mg/dl 27.8%, age >45years 27.2%, metabolic syndrome 11.5%, hypertension 9.4%, cocaine use 7%, and diabetes 2.9%. ART was associated with higher total-C and LDL-C concentrations, although also higher HDL-C and lower total-C/HDL-C ratio; patients receiving PIs boosted with a high ritonavir dose showed higher total-C levels and higher total-C/HDL-C ratio. According to Framingham cardiovascular, and coronary, REGICOR, and SCORE equations, 15.2%, 6.4%, 4.2% and 3.9% of patients, respectively, were classified as having moderate or high CVR.
  
  
  CONCLUSIONS
  In HIV-infected patients from CoRIS, prevalence of modifiable CVR factors is still high. Commonly used scores identify a relatively low number of patients with high CVR.
authors.affiliation: Hospital General Universitario de Elche, Universidad Miguel Hernández, Elche, España. marmasiac@gmail.com
authors.forename: Mar
authors.initials: M
authors.lastname: Masiá
authors.forename: Santiago
authors.initials: S
authors.lastname: Pérez-Cachafeiro
authors.forename: María
authors.initials: M
authors.lastname: Leyes
authors.forename: José
authors.initials: J
authors.lastname: López-Aldeguer
authors.forename: Mariola
authors.initials: M
authors.lastname: López
authors.forename: Ferrán
authors.initials: F
authors.lastname: Segura
authors.forename: José Ramón
authors.initials: JR
authors.lastname: Blanco
authors.forename: Alejandro
authors.initials: A
authors.lastname: Peña
authors.forename: Francisco
authors.initials: F
authors.lastname: Rodríguez
authors.forename: Mar
authors.initials: M
authors.lastname: Vera
authors.forename: Julia
authors.initials: J
authors.lastname: Del Amo
authors.forename: Félix
authors.initials: F
authors.lastname: Gutiérrez
mesh_terms: D000328:Adult; D002318:Cardiovascular Diseases / Q000209:etiology*; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D013030:Spain