title: Iron homeostasis in osteoporosis and its clinical implications.
abstract: Osteoporosis has until now been considered to be a disease associated with abnormal calcium metabolism. However, an increasing number of clinical observations strongly suggest the association of iron overload with bone diseases, particularly in osteoporosis in menopausal women. The recent identification of hepcidin sheds new light into the crucial role of iron homeostasis in bone metabolism. Decreasing iron overload in cell studies as well as in animal experiments has been shown to improve bone cell metabolism and growth in vitro and in vivo. In view of the significant iron overload found in the aging population, especially in females, the therapeutic potential of lowering iron overload for the treatment of osteoporosis is suggested.
authors.affiliation: Department of Orthopaedics, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
authors.forename: G F
authors.initials: GF
authors.lastname: Li
authors.forename: Y Z
authors.initials: YZ
authors.lastname: Pan
authors.forename: P
authors.initials: P
authors.lastname: Sirois
authors.forename: K
authors.initials: K
authors.lastname: Li
authors.forename: Y J
authors.initials: YJ
authors.lastname: Xu
mesh_terms: D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000502:physiology; D005260:Female; D064451:Hepcidins; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007501:Iron / Q000378:metabolism; D019190:Iron Overload / Q000150:complications*; D010024:Osteoporosis / Q000209:etiology* / Q000503:physiopathology
chemical_list: D023181:Antimicrobial Cationic Peptides; C578702:HAMP protein, human; D064451:Hepcidins; D007501:Iron