title: Treatment of Kaposi sarcoma-associated herpesvirus-associated cancers.
abstract: Kaposi sarcoma (KS) is the most frequent AIDS-defining cancer worldwide. KS-associated herpesvirus (KSHV) is the etiological agent of KS, and the virus is also associated with two lymphoproliferative diseases. Both KS and KSHV-associated lymphomas, are cancers of unique molecular composition. They represent a challenge for cancer treatment and an opportunity to identify new mechanisms of transformation. Here, we review the current clinical insights into KSHV-associated cancers and discuss scientific insights into the pathobiology of KS, primary effusion lymphoma, and multicentric Castleman's disease.
authors.affiliation: Program in Global Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill Chapel Hill, NC, USA.
authors.forename: Dirk P
authors.initials: DP
authors.lastname: Dittmer
authors.forename: Kristy L
authors.initials: KL
authors.lastname: Richards
authors.forename: Blossom
authors.initials: B
authors.lastname: Damania