title: Neuronal stem cells in the central nervous system and in human diseases.
abstract: The process of cortical expansion in the central nervous system is a key step of mammalian brain development to ensure its physiological function. Radial glial (RG) cells are a glial cell type contributing to this progress as intermediate neural progenitor cells responsible for an increase in the number of cortical neurons. In this review, we discuss the current understanding of RG cells during neurogenesis and provide further information on the mechanisms of neurodevelopmental diseases and stem cell-related brain tumorigenesis. Knowledge of neuronal stem cell and relative diseases will bridge benchmark research through translational studies to clinical therapeutic treatments of these diseases.
authors.affiliation: State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China. qianwu@moon.ibp.ac.cn
authors.forename: Qian
authors.initials: Q
authors.lastname: Wu
authors.forename: Xiaoqun
authors.initials: X
authors.lastname: Wang
mesh_terms: D014408:Biomarkers, Tumor / Q000378:metabolism; D001921:Brain / Q000254:growth & development / Q000502:physiology; D001932:Brain Neoplasms / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D005910:Glioma / Q000378:metabolism / Q000473:pathology / Q000628:therapy; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000737:chemistry / Q000378:metabolism; D054082:Lissencephaly / Q000378:metabolism / Q000473:pathology; D008831:Microcephaly / Q000378:metabolism / Q000473:pathology; D014411:Neoplastic Stem Cells / Q000166:cytology / Q000378:metabolism; D055495:Neurogenesis / Q000187:drug effects; D009457:Neuroglia / Q000166:cytology* / Q000378:metabolism; D047428:Protein Kinase Inhibitors / Q000737:chemistry / Q000494:pharmacology
chemical_list: D014408:Biomarkers, Tumor; D036341:Intercellular Signaling Peptides and Proteins; D047428:Protein Kinase Inhibitors