title: Design, synthesis, and anti-influenza viral activities of 1,3-diarylprop-2-en-1-ones: a novel class of neuraminidase inhibitors.
abstract: A series of 1,3-diarylprop-2-en-1-one derivatives 3a-v have been synthesized and evaluated for their ability to inhibit neuraminidase (NA). Among the prepared compounds, the less lipophilic derivative 3k showed the most potent in vitro inhibitory activity against NA with an IC(50) value of 1.5 μM.
authors.affiliation: Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute, Jeongup, 580-185, Korea.
authors.forename: Mayank
authors.initials: M
authors.lastname: Kinger
authors.forename: Yong Dae
authors.initials: YD
authors.lastname: Park
authors.forename: Jeong Hoon
authors.initials: JH
authors.lastname: Park
authors.forename: Min Goo
authors.initials: MG
authors.lastname: Hur
authors.forename: Hyung Jae
authors.initials: HJ
authors.lastname: Jeong
authors.forename: Su-Jin
authors.initials: SJ
authors.lastname: Park
authors.forename: Woo Song
authors.initials: WS
authors.lastname: Lee
authors.forename: Sang Wook
authors.initials: SW
authors.lastname: Kim
authors.forename: Seung Dae
authors.initials: SD
authors.lastname: Yang
mesh_terms: D000998:Antiviral Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D006801:Humans; D009980:Influenza A virus / Q000201:enzymology; D009981:Influenza B virus / Q000201:enzymology; D007251:Influenza, Human / Q000188:drug therapy* / Q000821:virology; D015394:Molecular Structure; D009439:Neuraminidase / Q000037:antagonists & inhibitors*; D011427:Propiophenones / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000998:Antiviral Agents; D011427:Propiophenones; D009439:Neuraminidase