title: Tissue-specific homing of immune cells in malignant skin tumors.
abstract: Tissue-specific migration of immune cells involved both in physiological and pathological immune responses is a current research subject for medical science. Several homing molecules have been identified orchestrating extravasation of immune cells to certain peripheral non-lymphoid tissues such as gut, lung and skin. Regarding lymphocyte homing to skin, the first-line defense of human body cutaneous lymphocyte associated antigen (CLA) and a group of chemokine-chemokine receptor pairs are considered to be of crucial importance. The aim of the present review is to summarize existing knowledge about skin- and tumor-specific migration of immune cells playing a major pathogenetic role in host immune responses induced by non-lymphoid malignant skin tumors as well as in the development of primary cutaneous T-cell lymphomas (CTCL). Melanoma malignum, squamous and basal cell carcinoma evoke host immune responses and consequently a subset of reactive immune cells is recruited to site of the tumor. Regarding migratory process and exact functional role of these cells a growing number of data is available in literature. On the other hand tissue-specific immune cell homing is regarded as a key process in the pathogenesis of CTCL where malignant T-lymphocytes can be found in circulation and symptomatic skin. Hereby homing mechanism of malignant T-cells in mycosis fungoides and Sézary-syndrome as separate clinical entities of CTCL is discussed. A precise insight into the molecular background of skin- and tumor-specific immune cell migration can contribute to developing efficient vaccine therapies in non-lymphoid malignant skin tumors and beneficial treatment modalities in CTCL.
authors.affiliation: Department of Dermatovenerology and Dermatooncology, Semmelweis University, Mária u. 41, Budapest, 1085, Hungary. jokaihajnalka@gmail.com
authors.forename: Hajnalka
authors.initials: H
authors.lastname: Jókai
authors.forename: Márta
authors.initials: M
authors.lastname: Marschalkó
authors.forename: Judit
authors.initials: J
authors.lastname: Csomor
authors.forename: József
authors.initials: J
authors.lastname: Szakonyi
authors.forename: Orsolya
authors.initials: O
authors.lastname: Kontár
authors.forename: Gábor
authors.initials: G
authors.lastname: Barna
authors.forename: Sarolta
authors.initials: S
authors.lastname: Kárpáti
authors.forename: Péter
authors.initials: P
authors.lastname: Holló
mesh_terms: D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology; D002277:Carcinoma / Q000276:immunology / Q000473:pathology; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000276:immunology / Q000473:pathology; D008545:Melanoma / Q000276:immunology / Q000473:pathology; D008562:Membrane Glycoproteins / Q000276:immunology; D009361:Neoplasm Invasiveness; D019707:Receptors, Chemokine / Q000276:immunology; D016201:Receptors, Lymphocyte Homing / Q000276:immunology*; D012878:Skin Neoplasms / Q000276:immunology* / Q000473:pathology
chemical_list: D000945:Antigens, Differentiation, T-Lymphocyte; C063419:CTAGE1 protein, human; D008562:Membrane Glycoproteins; D019707:Receptors, Chemokine; D016201:Receptors, Lymphocyte Homing