title: Quality assessment of reporting of animal studies on pathogenesis and treatment of peri-implant mucositis and peri-implantitis. A systematic review using the ARRIVE guidelines.
abstract: OBJECTIVE
  To address the following focused question: What is the quality of reporting of pre-clinical research for the study and treatment of mucositis/peri-implantitis?
  
  
  METHODS
  Electronic databases of the PubMed and the Cochrane Library were searched for animal studies reporting on pathogenesis or therapy of either peri-implant mucositits or peri-implantitis and completed by dual manual searches in duplicate between 1992 and May 2011. Quality assessment (i.e. grading of a checklist of 20 items in different categories) of selected full-text articles was performed according to the Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines.
  
  
  RESULTS
  Following screening, 75 publications were eligible for the review. For publications reporting on pathogenesis (n = 7) and therapy (n = 1) of peri-implant mucositis, minimum gradings were assigned to items 5 (Methods/Ethical Statement), 9 (Methods/Housing and husbandry), 11 (Methods/Allocation animals to experimental groups), 14 (Results/Baseline data), and 17 (Results/Adverse events). For publications reporting on pathogenesis (n = 34) and therapy (n = 33) of peri-implantitis, minimum grades were mainly assigned to items 9, 11, 14, and 17.
  
  
  CONCLUSIONS
  This systematic review has identified missing information in the publications on pre-clinical research for the study and treatment of mucositis/peri-implantitis.
authors.affiliation: Department of Oral Surgery, Heinrich Heine University, Düsseldorf, Germany. Frank.Schwarz@med.uni-duesseldorf.de
authors.forename: Frank
authors.initials: F
authors.lastname: Schwarz
authors.forename: Gerhard
authors.initials: G
authors.lastname: Iglhaut
authors.forename: Jürgen
authors.initials: J
authors.lastname: Becker
mesh_terms: D032761:Animal Experimentation / Q000592:standards*; D000818:Animals; D057189:Checklist; D015921:Dental Implants / Q000009:adverse effects; D017408:Guidelines as Topic; D057873:Peri-Implantitis / Q000209:etiology* / Q000628:therapy; D012107:Research Design / Q000592:standards*; D013280:Stomatitis / Q000209:etiology* / Q000628:therapy
chemical_list: D015921:Dental Implants