title: Recovery of influenza B virus with the H273Y point mutation in the neuraminidase active site from a human patient.
abstract: The H275Y oseltamivir resistance mutation confers high-level resistance to oseltamivir in isolates of human A(H1N1) influenza. We report the recovery and identification of an influenza B virus with the H273Y neuraminidase point mutation directly from a human patient. The H273Y influenza B isolate is resistant to oseltamivir and peramivir but sensitive to zanamivir.
authors.affiliation: Public Health Ontario, Toronto, Ontario, Canada. rachel.higgins@oahpp.ca
authors.forename: Rachel R
authors.initials: RR
authors.lastname: Higgins
authors.forename: Melissa
authors.initials: M
authors.lastname: Beniprashad
authors.forename: Eddie
authors.initials: E
authors.lastname: Chong-King
authors.forename: Yan
authors.initials: Y
authors.lastname: Li
authors.forename: Nathalie
authors.initials: N
authors.lastname: Bastien
authors.forename: Donald E
authors.initials: DE
authors.lastname: Low
authors.forename: Jonathan B
authors.initials: JB
authors.lastname: Gubbay
mesh_terms: D000146:Acids, Carbocyclic; D000328:Adult; D000998:Antiviral Agents / Q000494:pharmacology; D020134:Catalytic Domain; D003517:Cyclopentanes / Q000494:pharmacology; D024882:Drug Resistance, Viral; D006146:Guanidines / Q000494:pharmacology; D006801:Humans; D009981:Influenza B virus / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification*; D007251:Influenza, Human / Q000821:virology*; D008297:Male; D008969:Molecular Sequence Data; D020125:Mutation, Missense; D009439:Neuraminidase / Q000235:genetics*; D053139:Oseltamivir / Q000494:pharmacology; D017354:Point Mutation; D012367:RNA, Viral / Q000235:genetics; D017422:Sequence Analysis, DNA; D053243:Zanamivir / Q000494:pharmacology
chemical_list: D000146:Acids, Carbocyclic; D000998:Antiviral Agents; D003517:Cyclopentanes; D006146:Guanidines; D012367:RNA, Viral; D053139:Oseltamivir; D009439:Neuraminidase; D053243:Zanamivir; C414210:peramivir