title: Tumor suppressor activity of CBX7 in lung carcinogenesis.
abstract: The generation of knockout mice for the Cbx7 gene validates the tumor suppressor role of CBX7, whose expression is lost in several human malignancies. Indeed, these mice developed liver and lung adenomas and carcinomas. Cyclin E overexpression due to the lack of Cbx7 negative regulation of its expression likely accounts for the phenotype of the Cbx7-KO mice. A similar mechanism is likely involved in human lung carcinogenesis, since cyclin E upregulation associated with the loss of CBX7 expression has been observed in most of the human lung carcinomas analyzed.
authors.affiliation: Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Dipartimento di Biologia e Patologia Cellulare e Molecolare, Facoltà di Medicina e Chirurgia di Napoli, Università degli Studi di Napoli Federico II, Naples, Italy.
authors.forename: Floriana
authors.initials: F
authors.lastname: Forzati
authors.forename: Antonella
authors.initials: A
authors.lastname: Federico
authors.forename: Pierlorenzo
authors.initials: P
authors.lastname: Pallante
authors.forename: Monica
authors.initials: M
authors.lastname: Fedele
authors.forename: Alfredo
authors.initials: A
authors.lastname: Fusco
mesh_terms: D000818:Animals; D002277:Carcinoma / Q000378:metabolism* / Q000473:pathology; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D019927:Cyclin E / Q000235:genetics / Q000378:metabolism; D024003:HMGA Proteins / Q000378:metabolism; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology; D051379:Mice; D018345:Mice, Knockout; D063150:Polycomb Repressive Complex 1; D011401:Promoter Regions, Genetic; D012097:Repressor Proteins / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D015854:Up-Regulation
chemical_list: C519505:Cbx7 protein, mouse; D019927:Cyclin E; D024003:HMGA Proteins; D012097:Repressor Proteins; D063150:Polycomb Repressive Complex 1