title: Synthesis and antimicrobial evaluation of some pyrazole derivatives.
abstract: Reaction of a series of (E)-3-phenyl-4-(p-substituted phenyl)-3-buten-2-ones with p-sulfamylphenyl hydrazine in glacial acetic acid gave the corresponding hydrazones, subsequent treatment of which with 30% HCl afforded pyrazole-1-sulphonamides. On the other hand, refluxing of chalcones with either thiosemicarbazide or isonicotinic acid hydrazide in ethanol containing a few drops of acetic acid gave pyrazoline-1-thiocarboxamides and isonicotinoyl pyrazolines, respectively. The structures of the synthesized compounds were determined on the basis of their elemental analyses and spectroscopic data. The antimicrobial activity of the newly isolated heterocyclic compounds was evaluated against Gram-positive, Gram-negative bacteria and fungi. Most of the compounds showed a moderate degree of potent antimicrobial activity.
authors.affiliation: Department of Chemistry, Faculty of Science, Alexandria University, Alexandria 21321, Egypt. dressamsharshira@yahoo.com
authors.forename: Essam Mohamed
authors.initials: EM
authors.lastname: Sharshira
authors.forename: Nagwa Mohamed Mahrous
authors.initials: NM
authors.lastname: Hamada
mesh_terms: D019342:Acetic Acid / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002074:Butanones / Q000737:chemistry; D047188:Chalcones / Q000737:chemistry; D005658:Fungi / Q000187:drug effects* / Q000254:growth & development; D006090:Gram-Negative Bacteria / Q000187:drug effects* / Q000254:growth & development; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000254:growth & development; D006851:Hydrochloric Acid / Q000737:chemistry; D007538:Isoniazid / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D010659:Phenylhydrazines / Q000737:chemistry; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D013449:Sulfonamides / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D002074:Butanones; D047188:Chalcones; D010659:Phenylhydrazines; D011720:Pyrazoles; D013449:Sulfonamides; D019342:Acetic Acid; D006851:Hydrochloric Acid; D007538:Isoniazid