title: [Characteristics of paradontal recesses microbiocenosis and immune homeostasis in patients of elderly and senile age with chronic generalized periodontitis].
abstract: The microbiocenosis of periodontal recesses was studied and an assessment of the innate immunity mechanisms, as well as profiles of inflammatory cytokines were carried out in 114 people of middle, elderly and senile age with chronic generalized periodontitis (CGP). It was found that periodontal recesses mikrobiocenosis of patients with CGP of various ages was mainly presented by conditionally pathogenic bacterial and fungal microflora. There were identified the inefficient mechanisms of immune inflammation in case of conditionally pathogenic microflora, the reduction of neutrophils functional properties, and the increasing part of destructed phagocytazing neutrophils in patients of elderly and senile age. The immunosuppression in patients of elderly and senile age appears in insufficient production of IL-1beta, IL-8, resulting in reduced activity of phagocytosis mechanisms and lymphoid cells functional activity. Thus, the differences in etiopatogenetic microflora, immune homeostasis status in patients with CGP in middle, elderly and senile age, complexity in the application of antibacterial drugs require the development of new criteria for the selection of antibacterial drugs.
authors.forename: A K
authors.initials: AK
authors.lastname: Iordanishvili
authors.forename: S V
authors.initials: SV
authors.lastname: Soldatov
authors.forename: A V
authors.initials: AV
authors.lastname: Moskalev
authors.forename: L N
authors.initials: LN
authors.lastname: Soldatova
authors.forename: G A
authors.initials: GA
authors.lastname: Ryzhak
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000187:drug effects / Q000276:immunology*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D058448:Biota; D002175:Candida / Q000187:drug effects / Q000276:immunology / Q000302:isolation & purification; D055113:Chronic Periodontitis / Q000150:complications / Q000276:immunology / Q000382:microbiology / Q000503:physiopathology; D005260:Female; D006706:Homeostasis / Q000276:immunology*; D006801:Humans; D055633:Immune System Phenomena; D007113:Immunity, Innate; D007249:Inflammation / Q000276:immunology; D016209:Interleukin-8 / Q000378:metabolism; D008297:Male; D059013:Microbial Consortia / Q000187:drug effects / Q000276:immunology; D008875:Middle Aged; D009504:Neutrophils / Q000378:metabolism; D010514:Periodontal Pocket / Q000188:drug therapy / Q000209:etiology / Q000276:immunology / Q000503:physiopathology; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D016209:Interleukin-8