title: Two piperazic acid-containing cyclic hexapeptides from Streptomyces alboflavus 313.
abstract: Two novel cyclic hexapeptides, designated NW-G10 (1) and NW-G11 (2), were isolated from the fermentation broth of Streptomyces alboflavus 313. Their relative structures were elucidated on the basis of extensive spectroscopic analysis, and the absolute configurations of several constituent amino acids were determined by Marfey's method. NW-G10 (1) and NW-G11 (2) exhibited significant activity against Gram-positive bacteria, such as Bacillus cereus, Bacillus subtilis and Staphylococcus aureus, including methicillin-resistant Staphylococcus aureus (MRSA), but they are not active against gram negatives.
authors.affiliation: College of Plant Protection, Northwest A&F University, Yangling 712100, Shaanxi, People's Republic of China.
authors.forename: Shaopeng
authors.initials: S
authors.lastname: Wei
authors.forename: Lixia
authors.initials: L
authors.lastname: Fan
authors.forename: Wenjun
authors.initials: W
authors.lastname: Wu
authors.forename: Zhiqin
authors.initials: Z
authors.lastname: Ji
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001409:Bacillus cereus / Q000187:drug effects / Q000254:growth & development; D001412:Bacillus subtilis / Q000187:drug effects / Q000254:growth & development; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects / Q000254:growth & development; D008826:Microbial Sensitivity Tests; D050296:Microbial Viability / Q000187:drug effects; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000302:isolation & purification* / Q000494:pharmacology; D011724:Pyridazines / Q000737:chemistry*; D013302:Streptomyces / Q000737:chemistry* / Q000378:metabolism; D053719:Tandem Mass Spectrometry
chemical_list: D000900:Anti-Bacterial Agents; D010456:Peptides, Cyclic; D011724:Pyridazines; C014756:piperazic acid