title: [Antimicrobial resistance among E. coli in urinary specimens: prevalence data from three laboratories in Zurich between 1985 and 2010].
abstract: Urinary tract infections in women are common. Drug resistance among Escherichia coli, the most frequent uropathogen, has increased worldwide. In a prevalence study we investigated the local antibiotic susceptibility of this microorganism in urinary specimens of three laboratories in Zurich. Resistance rates against trimethoprim-sulfamethoxazole 2010 were 28%, 16% against quinolones and 16% against amoxicillin/clavulanic acid. Resistance prevalence for nitrofurantoin and fosfomycin were low with 3,6%, resp. 0,7%. The rate of extended-spectrum beta-lactamase-producing E. coli has rapidly increased to 4,3% in 2010. Based on this data and according to the international guidelines for the treatment of uncomplicated cystitis, therapy with trimethoprim-sulfamethoxazole and quinolones are no longer recommended. Nitrofurantoin and Fosfomycin are an appropriate choice. Microbiological testing is advised.
authors.affiliation: Klinik für Infektionskrankheiten und Spitalhygiene, Universität Zürich, Universitätsspital Zürich, Zürich. helen.kovari@usz.ch
authors.forename: F
authors.initials: F
authors.lastname: Savaria
authors.forename: R
authors.initials: R
authors.lastname: Zbinden
authors.forename: J
authors.initials: J
authors.lastname: Wüst
authors.forename: A
authors.initials: A
authors.lastname: Burnens
authors.forename: B
authors.initials: B
authors.lastname: Ledergerber
authors.forename: R
authors.initials: R
authors.lastname: Weber
authors.forename: H
authors.initials: H
authors.lastname: Kovari
mesh_terms: D003556:Cystitis / Q000188:drug therapy / Q000382:microbiology; D024901:Drug Resistance, Multiple, Bacterial; D004926:Escherichia coli / Q000187:drug effects*; D004927:Escherichia coli Infections / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D006801:Humans; D013557:Switzerland; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000382:microbiology