title: Acute inflammatory demyelinating polyradiculoneuropathy in a patient receiving oxaliplatin-based chemotherapy.
abstract: We report a case of acute inflammatory demyelinating polyradiculoneuropathy (AIDP) that developed in a patient with cholangiocarcinoma after receiving oxaliplatin-based chemotherapy. A 62-year-old man had multiple hypodense lesions with delayed enhancement in the both lobes of the liver on abdominal computed tomography. He was treated with 5-fluorouracil, leucovorin and oxaliplatin (100 mg/m(2)). After eight cycles of treatment and a cumulative oxaliplatin dose of 780 mg/m(2), he developed an unsteady gait, dysphagia, weakness of both the upper and lower limbs and impairment of all sensory modalities. Nerve conduction studies confirmed the diagnosis of AIDP. Immunoglobulin G i.v. was administered for 5 days but the neurological deficits of both his upper and lower limbs did not improve. This case highlights unusual peripheral nervous system manifestations in a patient who received chemotherapy with oxaliplatin.
authors.affiliation: Hematology-Oncology, Chonnam National University Medical School, Gwangju, Republic of Korea.
authors.forename: Ju Young
authors.initials: JY
authors.lastname: Yoon
authors.forename: Tai Seung
authors.initials: TS
authors.lastname: Nam
authors.forename: Myeong Kyu
authors.initials: MK
authors.lastname: Kim
authors.forename: Jun Eul
authors.initials: JE
authors.lastname: Hwang
authors.forename: Hyun-Jeong
authors.initials: HJ
authors.lastname: Shim
authors.forename: Sang Hee
authors.initials: SH
authors.lastname: Cho
authors.forename: Ik Joo
authors.initials: IJ
authors.lastname: Chung
authors.forename: Woo Kyun
authors.initials: WK
authors.lastname: Bae
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects*; D001650:Bile Duct Neoplasms / Q000188:drug therapy; D018281:Cholangiocarcinoma / Q000188:drug therapy; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects; D020275:Guillain-Barre Syndrome / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage / Q000009:adverse effects; D008113:Liver Neoplasms / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009944:Organoplatinum Compounds / Q000008:administration & dosage / Q000009:adverse effects*; D000077150:Oxaliplatin
chemical_list: D009944:Organoplatinum Compounds; D000077150:Oxaliplatin; D002955:Leucovorin; D005472:Fluorouracil