title: Expression of selected neuropeptides in pathogenesis of bullous pemphigoid and dermatitis herpetiformis.
abstract: Bullous pemphigoid (BP) and dermatitis herpetiformis (DH) are chronic subepidermal bullous diseases, which progress together with an itch and an inflammatory reaction. These symptoms may be the cause of a phenomenon described in the literature as a neurogenic skin inflammation. Neuropeptides are one of the mediators which take part in this process. The aim of our study was to indicate the expression of selected neuropeptides - CRF (corticotropin releasing factor), CGRP (calcitonin gene-related peptide), NKB (neurokinin B), SP (substance P) and the receptor for endothelin B (ETRB) - in the skin of patients suffering from BP or DH. A significantly increased expression of CRF was found in the specimen collected from the skin lesions of patients with BP and DH as well as a significantly increased expression of receptor for endothelin B in the patients with DH by the immunohistochemical method. The results obtained give evidence of a possible participation of CRF and receptor for endothelin B in the pathogenesis of the itch in the dermatitis herpetiformis as well as CRF in bullous pemphigoid.
authors.affiliation: Department of Dermatology and Venereology, Medical University of Lodz, Lodz, Poland. anka_nykiel@wp.pl
authors.forename: Anna
authors.initials: A
authors.lastname: Cynkier
authors.forename: Agnieszka
authors.initials: A
authors.lastname: Zebrowska
authors.forename: Małgorzata
authors.initials: M
authors.lastname: Wągrowska-Danilewicz
authors.forename: Marian
authors.initials: M
authors.lastname: Danilewicz
authors.forename: Anna
authors.initials: A
authors.lastname: Erkiert-Polguj
authors.forename: Olga
authors.initials: O
authors.lastname: Stasikowska-Kanicka
authors.forename: Anna
authors.initials: A
authors.lastname: Sysa-Jędrzejowska
authors.forename: Elżbieta
authors.initials: E
authors.lastname: Waszczykowska
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015740:Calcitonin Gene-Related Peptide / Q000032:analysis / Q000096:biosynthesis; D003346:Corticotropin-Releasing Hormone / Q000032:analysis / Q000096:biosynthesis; D003874:Dermatitis Herpetiformis / Q000150:complications / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D015287:Neurokinin B / Q000032:analysis / Q000096:biosynthesis; D009479:Neuropeptides / Q000032:analysis / Q000096:biosynthesis*; D010391:Pemphigoid, Bullous / Q000150:complications / Q000378:metabolism*; D011537:Pruritus / Q000209:etiology / Q000378:metabolism*; D044023:Receptor, Endothelin B / Q000032:analysis / Q000096:biosynthesis; D013373:Substance P / Q000032:analysis / Q000096:biosynthesis
chemical_list: D009479:Neuropeptides; D044023:Receptor, Endothelin B; D013373:Substance P; D015287:Neurokinin B; D003346:Corticotropin-Releasing Hormone; D015740:Calcitonin Gene-Related Peptide