title: Dietary supplementation of female rats with elk velvet antler improves physical and neurological development of offspring.
abstract: Elk velvet antler (EVA) has a traditional use for promotion of general health. However, evidence of EVA effects at different lifestages is generally lacking. This paper investigated the effects of long-term maternal dietary EVA supplementation on physical, reflexological and neurological development of rat offspring. Female Wistar rats were fed standard chow or chow containing 10% EVA for 90 days prior to mating and throughout pregnancy and lactation. In each dietary group, 56 male and 56 female pups were assessed for physical, neuromotor, and reflexologic development postnatally. Among the examined physical developmental parameters, incisor eruption occurred one day earlier in pups nursing dams receiving EVA. Among neuromotor developmental parameters, duration of supported and unsupported standing was longer for pups nursing EVA supplemented dams. Acquisition of neurological reflex parameters (righting reflex, negative geotaxis, cliff avoidance acoustic startle) occurred earlier in pups nursing dams receiving EVA. Longterm maternal EVA supplementation prior to and during pregnancy and lactation accelerated certain physical, reflexologic, and neuromotor developmental milestones and caused no discernible adverse effects on developing offspring. The potential benefits of maternal EVA supplementation on postnatal development warrants further investigation to determine whether EVA can be endorsed for the promotion of maternal and child health.
authors.affiliation: Key Laboratory of New Animal Drug Project of Gansu Province, Key Laboratory of Research and Development for Veterinary Pharmaceutics, Ministry of Agriculture, Lanzhou Institute of Animal Science and Veterinary Pharmaceutics, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu 730050, China.
authors.forename: Jiongran
authors.initials: J
authors.lastname: Chen
authors.forename: Murray R
authors.initials: MR
authors.lastname: Woodbury
authors.forename: Jane
authors.initials: J
authors.lastname: Alcorn
authors.forename: Ali
authors.initials: A
authors.lastname: Honaramooz