title: The relationship between urinary bisphenol A levels and meningioma in Chinese adults.
abstract: BACKGROUND
  Estrogen has been implicated as a risk factor for meningioma. Bisphenol A (BPA), a widely used synthetic xenoestrogen, has already been reported to be associated with several estrogen-sensitive tumors.
  
  
  METHODS
  An exploratory association study of 243 meningioma cases and 258 frequency-matched healthy controls was conducted, using subjects from a hospital-based study to demonstrate the association of urine BPA concentration and the risk of meningioma. The specimens and data of patients were collected at Union Hospital, Wuhan, China, from 2009 to 2010.
  
  
  RESULTS
  A positive association between increasing levels of urinary BPA and meningioma was observed, independent of confounding factors such as gender, age, race, body mass index, HRT use, BMI, and family history of cancer. Compared to quartile 1 (referent), the multivariate-adjusted odds ratio of meningioma associated with quartile 4 was 1.45 (95 % CI, 1.02-1.98) (P trend = 0.03).
  
  
  CONCLUSIONS
  In this case-control study from China, a clear association between urinary BPA concentrations and diagnosis of meningioma was detected.
authors.affiliation: Department of Neurosurgery, Union Hospital, Huazhong University of Science and Technology, Wuhan, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Duan
authors.forename: Xuebin
authors.initials: X
authors.lastname: Hu
authors.forename: Hongyang
authors.initials: H
authors.lastname: Zhao
authors.forename: Jun
authors.initials: J
authors.lastname: Qin
authors.forename: Jie
authors.initials: J
authors.lastname: Luo
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D001559:Benzhydryl Compounds / Q000652:urine*; D015992:Body Mass Index; D016022:Case-Control Studies; D004785:Environmental Pollutants / Q000652:urine*; D005260:Female; D006801:Humans; D008297:Male; D008579:Meningioma / Q000175:diagnosis* / Q000473:pathology / Q000652:urine*; D008875:Middle Aged; D010636:Phenols / Q000652:urine*; D012307:Risk Factors; D000098826:Bisphenol A Compounds
chemical_list: D001559:Benzhydryl Compounds; D004785:Environmental Pollutants; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds