title: Characterization and photodynamic activity of a new phthalocyanine nanoparticles.
abstract: Nanoparticles of a hydrophobic photosensitizer, tetrakis (3-trifluoromethylphenoxy) zinc phthalocyanine (FPcZn) have been synthesized by using a simple reprecipitation technique. The resulting drug nanoparticles (FPcZn-NP) were spherical, highly monodispersed and stable in aqueous system, without an additional stabilizer. Comparative studies with FPcZn-NP and FPcZn indicated that after the formation of nanoparticles, FPcZn-NP maintained the efficiency of (1)O(2) generation. Further more, the in vitro studies demonstrated that such nanoparticles can be efficiently taken up by Hela cells, which might be resulted to cell death by light irradiation. These properties could make the FPcZn-NP to be a promising candidate in clinical photodynamic therapy.
authors.affiliation: Jiangsu Key Laboratory of Biofunctional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing, 210046, People's Republic of China.
authors.forename: Rui
authors.initials: R
authors.lastname: Lin
authors.forename: Lin
authors.initials: L
authors.lastname: Zhou
authors.forename: Ke-Long
authors.initials: KL
authors.lastname: Fang
authors.forename: Yun
authors.initials: Y
authors.lastname: Lin
authors.forename: Ao
authors.initials: A
authors.lastname: Wang
authors.forename: Jia-Hong
authors.initials: JH
authors.lastname: Zhou
authors.forename: Shao-Hua
authors.initials: SH
authors.lastname: Wei
mesh_terms: D006367:HeLa Cells; D006801:Humans; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology*; D054833:Isoindoles; D046529:Microscopy, Electron, Transmission; D053758:Nanoparticles; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry / Q000494:pharmacology*; D026082:Singlet Oxygen / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet
chemical_list: D007211:Indoles; D054833:Isoindoles; D017319:Photosensitizing Agents; D026082:Singlet Oxygen; C013647:phthalocyanine