title: Hodgkin lymphoma in patients with HIV infection: a review.
abstract: Hodgkin lymphoma (HL) is one of the most common types of non-AIDS-defining tumors in the HIV-infected. Its incidence however seems to have increased under highly active anti-retroviral therapy (HAART). HIV-HL is a different entity from HL in HIV-negative subjects with a poorer prognosis that is associated with tumor-subtype, EBV-infection, and "B" symptoms. Despite the aggressive nature of the disease, clinical outcome has improved with combination therapies including appropriately timed antiretroviral strategies and the quality of supportive care-notably the use of hematopoietic growth factors. More intensive chemotherapy regimens with or without autologous stem cell transplantation appear to improve survival. Functional imaging such as positron emission tomography and computed tomography (FDG-PET) may help guide treatment strategy and minimize long-term toxicity.
authors.affiliation: Hematology/Oncology Department, L'Archet Hospital, Nice, France.
authors.forename: Nihal
authors.initials: N
authors.lastname: Martis
authors.forename: Nicolas
authors.initials: N
authors.lastname: Mounier
mesh_terms: D019380:Anti-HIV Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D060085:Coinfection / Q000821:virology; D020031:Epstein-Barr Virus Infections / Q000150:complications; D019788:Fluorodeoxyglucose F18; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D006689:Hodgkin Disease / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology*; D049268:Positron-Emission Tomography; D011379:Prognosis
chemical_list: D019380:Anti-HIV Agents; D019788:Fluorodeoxyglucose F18