title: Phylogenetic classification of diverse LysR-type transcriptional regulators of a model prokaryote Geobacter sulfurreducens.
abstract: The protein family of LysR-type transcriptional regulators (LTTRs) is highly abundant among prokaryotes. We analyzed 10,145 non-redundant microbial sequences with homology to eight LysR family regulators of a model prokaryote, Geobacter sulfurreducens, and employed phylogenetic tree inference for LTTR classification. We also analyzed the arrangement of genome clusters containing G. sulfurreducens LTTR genes and searched for LTTR regulatory motifs, suggesting likely regulatory targets of G. sulfurreducens LTTRs. This is the first study to date providing a detailed classification of LTTRs in the deltaproteobacterial family Geobacteraceae.
authors.affiliation: Department of Preventive Medicine, The University of Tennessee Health Science Center, Memphis, TN 38163, USA. krushkal@gmail.com
authors.forename: Julia
authors.initials: J
authors.lastname: Krushkal
authors.forename: Yanhua
authors.initials: Y
authors.lastname: Qu
authors.forename: Derek R
authors.initials: DR
authors.lastname: Lovley
authors.forename: Ronald M
authors.initials: RM
authors.lastname: Adkins
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics*; D001483:Base Sequence; D045302:Geobacter / Q000235:genetics*; D008969:Molecular Sequence Data; D005810:Multigene Family; D059372:Nucleotide Motifs / Q000235:genetics; D010802:Phylogeny; D017422:Sequence Analysis, DNA; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D001426:Bacterial Proteins; D014157:Transcription Factors; C073470:LysR protein, Bacteria