title: Changes of the immunological and haematological parameters in rabbits after bendiocarbamate application.
abstract: The effect of bendiocarbamate application (5 mg/kg b.w.) on the haematological and immunological parameters in rabbits was evaluated. Total leukocyte cell count, erythrocyte cell count, differential cell count were determined during the period of three months of bendiocarbamate application and compared with those in healthy animals. The immunotoxic effect was evaluated by the test of ingestion ability of phagocytes (phagocytic activity and index of phagocytic activity) and proliferation activity of lymphocytes after mitogen stimulation. The significant decrease of total leukocytes, lymphocytosis and neutropaenia were found after bendiocarbamate application. The functional activities of phagocytes (expressed as phagocytic activity) and lymphocytes (proliferative activity) were significantly suppressed in rabbits treated with bendiocarbamate compared with those in control groups and values before the experiment.
authors.affiliation: Department of Epizootology and Parasitology, University of Veterinary Medicine and Pharmacy, Kosice, Slovak Republic.
authors.forename: Jana
authors.initials: J
authors.lastname: Mojzisova
authors.forename: Peter
authors.initials: P
authors.lastname: Massányi
authors.forename: Jan
authors.initials: J
authors.lastname: Danko
authors.forename: Alexandra
authors.initials: A
authors.lastname: Trbolova
authors.forename: Eva
authors.initials: E
authors.lastname: Petrovova
authors.forename: David
authors.initials: D
authors.lastname: Mazensky
authors.forename: Katarina
authors.initials: K
authors.lastname: Vdoviakova
authors.forename: Lenka
authors.initials: L
authors.lastname: Luptakova
authors.forename: Norbert
authors.initials: N
authors.lastname: Torma
mesh_terms: D000818:Animals; D001772:Blood Cell Count; D002219:Carbamates / Q000633:toxicity*; D007107:Immune System / Q000187:drug effects*; D011817:Rabbits
chemical_list: D002219:Carbamates