title: Staphylococcus aureus bloodstream infections in children: A population-based assessment.
abstract: BACKGROUND
  Although Staphylococcus aureus is a major cause of bloodstream infections, population-based data on these infections in children are limited.
  
  
  OBJECTIVE
  To describe the epidemiology of S aureus bacteremia in children.
  
  
  METHODS
  Population-based surveillance for all incident S aureus bacteremias was conducted among children (18 years of age or younger) living in the Calgary Health Region (Alberta) from 2000 to 2006.
  
  
  RESULTS
  During the seven-year study, 120 S aureus bloodstream infections occurred among 119 patients; 27% were nosocomial, 18% health care associated and 56% community acquired. The annual incidence was 6.5/100,000 population and 0.094/1000 live births. A total of 52% had a significant underlying condition, and this was higher for nosocomial cases. Bone and joint (40%), bacteremia without a focus (33%), and skin and soft tissue infections (15%) were the most common clinical syndromes. Infections due to methicillin-resistant S aureus were uncommon (occurring in one infection) and three patients (2.5%) died.
  
  
  CONCLUSIONS
  S aureus bacteremia is an important cause of morbidity in the paediatric age group. Underlying medical conditions and implanted devices are important risk factors. Methicillin-resistant S aureus and mortality rates are low.
authors.affiliation: Department of Paediatrics;
authors.forename: Otto G
authors.initials: OG
authors.lastname: Vanderkooi
authors.forename: Daniel B
authors.initials: DB
authors.lastname: Gregson
authors.forename: James D
authors.initials: JD
authors.lastname: Kellner
authors.forename: Kevin B
authors.initials: KB
authors.lastname: Laupland