title: Reduced sulfate plasma concentrations in the BTBR T+tf/J mouse model of autism.
abstract: Clinical studies have shown that children diagnosed with autism show abnormal sulfate chemistry, which is critical for cellular and metabolic processes. To determine if the inbred BTBR T+tf/J mouse shows autism-relevant aberrations in sulfate chemistry, the present study examined plasma sulfate concentrations in BTBR T+tf/J, inbred C57BL/6J, and outbred CD-1 mice. Results showed that the BTBR T+tf/J mouse exhibits significantly lower plasma sulfate concentrations in comparison to both C57BL/6J and CD-1 mice. These results suggest that the BTBR mouse shows autism-relevant abnormalities in sulfate chemistry and may serve additional utility in examining the role of sulfate and sulfate-dependent systems in relation to autism-relevant behavioral aberrations.
authors.affiliation: Department of Psychology, University of Hawaii, Honolulu, HI, USA. mcorley@hawaii.edu
authors.forename: Michael J
authors.initials: MJ
authors.lastname: Corley
authors.forename: Ksenia Z
authors.initials: KZ
authors.lastname: Meyza
authors.forename: D Caroline
authors.initials: DC
authors.lastname: Blanchard
authors.forename: Robert J
authors.initials: RJ
authors.lastname: Blanchard
mesh_terms: D000818:Animals; D001321:Autistic Disorder / Q000097:blood*; D004195:Disease Models, Animal; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000097:blood; D008815:Mice, Inbred Strains / Q000097:blood; D013431:Sulfates / Q000097:blood*
chemical_list: D013431:Sulfates