title: Biomarkers of deep venous thrombosis.
abstract: Deep venous thrombosis (DVT), which is associated with pulmonary embolism, is a fatal disease because of its high morbidity and mortality in outpatients and inpatients, especially in hospitalized patients. At the same time, lack of subjective clinical symptoms and objective clinical signs makes the diagnosis complicated. Historically, the primarily imaging modalities, including duplex ultrasound, helical CT scans, and venography, establish the diagnosis of DVT. Currently, both imaging modalities and serology are utilized. These plasma molecules are regarded as the biomarkers of DVT including D-dimer, P-selectin, Factor VIII, thrombin generation, inflammatory cytokines, microparticles, fibrin monomer, leukocyte count and so on. This brief review is used to analyze the contribution of the biomarkers to diagnosis and guidance of therapy for DVT.
authors.affiliation: The Center of Diagnosis and Treatment for Joint Disease, Nanjing Drum Tower Hospital Affiliated to Medical School of Nanjing University, Northern Zhongshan Road, Nanjing, 210008, Jiangsu, People's Republic of China. houhuach@126.com
authors.forename: Huacheng
authors.initials: H
authors.lastname: Hou
authors.forename: Zhijuan
authors.initials: Z
authors.lastname: Ge
authors.forename: Pu
authors.initials: P
authors.lastname: Ying
authors.forename: Jin
authors.initials: J
authors.lastname: Dai
authors.forename: Dongquan
authors.initials: D
authors.lastname: Shi
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Xu
authors.forename: Dongyang
authors.initials: D
authors.lastname: Chen
authors.forename: Qing
authors.initials: Q
authors.lastname: Jiang
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood; D055252:Cell-Derived Microparticles / Q000378:metabolism*; D016207:Cytokines / Q000097:blood*; D005169:Factor VIII / Q000378:metabolism*; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism*; D006801:Humans; D019007:P-Selectin / Q000097:blood*; D010690:Phlebography; D013917:Thrombin / Q000378:metabolism*; D036542:Tomography, Spiral Computed; D014463:Ultrasonography; D020246:Venous Thrombosis / Q000097:blood* / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000628:therapy
chemical_list: D015415:Biomarkers; D016207:Cytokines; D005338:Fibrin Fibrinogen Degradation Products; D019007:P-Selectin; C036309:fibrin fragment D; C078147:F8 protein, human; D005169:Factor VIII; D013917:Thrombin