title: Variation in reported neonatal group B streptococcal disease incidence in developing countries.
abstract: Group B Streptococcus (GBS) is a leading cause of neonatal sepsis in developed countries. Its burden in the developing world is less clear. Studies reporting neonatal GBS disease incidence from developing countries were identified from 5 literature databases. Studies were assessed with respect to case finding and culture methods. Only 20 studies were identified. The GBS incidence ranged 0-3.06 per 1000 live births with variation within and between geographic regions. All but 1 study identified GBS cases within a hospital setting, despite the potential for births in the community. Possible case under-ascertainment was only discussed in 2 studies. A higher GBS incidence was reported when using automated culture methods. Prospective, population-based surveillance is urgently needed in developing countries to provide an accurate assessment of the neonatal GBS disease burden. This will be crucial for the design of interventions, including novel vaccines, and the understanding of their potential to impact mortality from neonatal sepsis.
authors.affiliation: Immunology and Parasitology, Department of Microbiology, College of Health Sciences, Mekelle University, Ethiopia.
authors.forename: Alemnew F
authors.initials: AF
authors.lastname: Dagnew
authors.forename: Marianne C
authors.initials: MC
authors.lastname: Cunnington
authors.forename: Queen
authors.initials: Q
authors.lastname: Dube
authors.forename: Morven S
authors.initials: MS
authors.lastname: Edwards
authors.forename: Neil
authors.initials: N
authors.lastname: French
authors.forename: Robert S
authors.initials: RS
authors.lastname: Heyderman
authors.forename: Shabir A
authors.initials: SA
authors.lastname: Madhi
authors.forename: Karen
authors.initials: K
authors.lastname: Slobod
authors.forename: Sue Ann Costa
authors.initials: SA
authors.lastname: Clemens
mesh_terms: D001431:Bacteriological Techniques; D003906:Developing Countries / Q000706:statistics & numerical data*; D018563:Disease Notification; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000453:epidemiology* / Q000382:microbiology*; D013290:Streptococcal Infections / Q000453:epidemiology*; D013292:Streptococcus agalactiae / Q000302:isolation & purification*