title: [The influence of calcium N-(5-hydroxynicotinoyl)-L-glutamate on reproductive function, prenatal and postnatal development of rats].
abstract: The safety of a new nootrope and neuroprotector--calcium N-(5-hydroxynicotinoyl)-L-glutamate (ampasse)--has been evaluated. It is shown that ampasse at a dose of 6.7 mg/kg (10 times the maximum therapeutic dose for humans) did not affect the reproductive function in experimental animals and did not produced any embryotoxic and teratogenic effects.
authors.forename: A V
authors.initials: AV
authors.lastname: Kiselev
authors.forename: S V
authors.initials: SV
authors.lastname: Stovbun
authors.forename: V I
authors.initials: VI
authors.lastname: Sergienko
mesh_terms: D000818:Animals; D002118:Calcium / Q000737:chemistry; D030762:Estrous Cycle / Q000187:drug effects / Q000502:physiology; D005260:Female; D005298:Fertility / Q000187:drug effects* / Q000502:physiology; D005325:Fetal Organ Maturity / Q000187:drug effects; D005328:Fetal Viability / Q000187:drug effects; D020567:Fetal Weight / Q000187:drug effects; D005333:Fetus; D005971:Glutamates / Q000138:chemical synthesis / Q000633:toxicity*; D006801:Humans; D007273:Injections, Intramuscular; D008098:Litter Size / Q000187:drug effects; D008297:Male; D018696:Neuroprotective Agents / Q000138:chemical synthesis / Q000633:toxicity*; D009539:Nicotinic Acids / Q000138:chemical synthesis / Q000633:toxicity*; D018697:Nootropic Agents / Q000138:chemical synthesis / Q000633:toxicity*; D010298:Parity / Q000187:drug effects / Q000502:physiology; D011247:Pregnancy; D051381:Rats; D012098:Reproduction / Q000187:drug effects* / Q000502:physiology
chemical_list: D005971:Glutamates; D018696:Neuroprotective Agents; D009539:Nicotinic Acids; D018697:Nootropic Agents; C066295:nooglutil; D002118:Calcium