title: Depression in elderly persons subject to childhood maltreatment is not modulated by corpus callosum and hippocampal loss.
abstract: Childhood adversity has been observed to engender structural changes in the hippocampus and corpus callosum associated with increased risk for depression in childhood and early adulthood. This study investigated this association in the elderly. Corpus callosum area and hippocampal volume were measured from structural MRI in 427 community dwelling elderly. Information on childhood adversity was obtained in the course of a clinical examination using a questionnaire covering multiple aspects of abuse. Multivariate analyses found a significant increase in corpus callosum area and hippocampal volume in subjects exposed to mental disorder in parents and poverty, respectively. No association was found with childhood sexual and physical abuse.
authors.affiliation: Inserm, U1061, Montpellier, F-34093, France. karen.ritchie@inserm.fr
authors.forename: Karen
authors.initials: K
authors.lastname: Ritchie
authors.forename: Isabelle
authors.initials: I
authors.lastname: Jaussent
authors.forename: Florence
authors.initials: F
authors.lastname: Portet
authors.forename: Philippe
authors.initials: P
authors.lastname: Courtet
authors.forename: Alain
authors.initials: A
authors.lastname: Malafosse
authors.forename: Jerome
authors.initials: J
authors.lastname: Maller
authors.forename: Chantal
authors.initials: C
authors.lastname: Meslin
authors.forename: Alain
authors.initials: A
authors.lastname: Bonafé
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Le Bars
authors.forename: Nicolas Menjot
authors.initials: NM
authors.lastname: de Champfleur
authors.forename: Sylvaine
authors.initials: S
authors.lastname: Artero
authors.forename: Marie-Laure
authors.initials: ML
authors.lastname: Ancelin
mesh_terms: D054523:Adult Survivors of Child Abuse; D000367:Age Factors; D000368:Aged; D016241:Child of Impaired Parents; D003337:Corpus Callosum / Q000473:pathology*; D003863:Depression / Q000209:etiology* / Q000523:psychology; D003866:Depressive Disorder; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D001523:Mental Disorders; D009929:Organ Size; D011203:Poverty; D011795:Surveys and Questionnaires