title: Limitations of gene duplication models: evolution of modules in protein interaction networks.
abstract: It has been generally acknowledged that the module structure of protein interaction networks plays a crucial role with respect to the functional understanding of these networks. In this paper, we study evolutionary aspects of the module structure of protein interaction networks, which forms a mesoscopic level of description with respect to the architectural principles of networks. The purpose of this paper is to investigate limitations of well known gene duplication models by showing that these models are lacking crucial structural features present in protein interaction networks on a mesoscopic scale. This observation reveals our incomplete understanding of the structural evolution of protein networks on the module level.
authors.affiliation: Computational Biology and Machine Learning Lab, Center for Cancer Research and Cell Biology, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, United Kingdom. v@bio-complexity.com
authors.forename: Frank
authors.initials: F
authors.lastname: Emmert-Streib
mesh_terms: D000465:Algorithms; D016000:Cluster Analysis; D019143:Evolution, Molecular; D020440:Gene Duplication; D008957:Models, Genetic; D060066:Protein Interaction Maps