title: Beneficial modulation from a high-purity caviar-derived homogenate on chronological skin aging.
abstract: This study tested the activity of LD-1227, which contains a caviar-derived homogenate added with coenzyme Q(10) (CoQ(10))-selenium component (CaviarLieri(®), Lab-Dom, Switzerland), in aged human skin and its potential role on skin mitochondria function. Human dermal fibroblasts were obtained from healthy donors over 70 years old and treated with LD-1227 for 72 hr. As compared to baseline, LD-1227 caused a robust (>67%) collagen type I synthesis (p<0.001) and decreased fibronectin synthesis (p<0.05) with significant fibronectin messenger RNA (mRNA) downregulation (p<0.05, r=0.78). A significant collagen mRNA overexpression occurred with LD-1227 treatment (p<0.05). Mitochondria cytosolic adenosine triphosphate (ATP) level decreased in aged skin samples (p<0.05 vs. young control), but this phenomenon was reversed by LD-1227 (p<0.01). These data show that LD-1227 may modify the extracellular matrix milieu in aged skin and also beneficially affect mitochondrial function.
authors.affiliation: ReGenera Res Group for Aging Intervention, Milan, Italy. fmarchimede@libero.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Marotta
authors.forename: Ascanio
authors.initials: A
authors.lastname: Polimeni
authors.forename: Umberto
authors.initials: U
authors.lastname: Solimene
authors.forename: Aldo
authors.initials: A
authors.lastname: Lorenzetti
authors.forename: Emilio
authors.initials: E
authors.lastname: Minelli
authors.forename: Shalini
authors.initials: S
authors.lastname: Jain
authors.forename: Reza
authors.initials: R
authors.lastname: Rastmanesh
authors.forename: Sonia
authors.initials: S
authors.lastname: Sedriep
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Soresi
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000328:Adult; D000368:Aged; D000375:Aging; D000818:Animals; D003094:Collagen / Q000378:metabolism; D015536:Down-Regulation; D004531:Eggs; D005109:Extracellular Matrix / Q000378:metabolism; D005353:Fibronectins / Q000096:biosynthesis; D005396:Fish Products; D005399:Fishes; D006801:Humans; D012333:RNA, Messenger / Q000378:metabolism; D015595:Skin Aging / Q000187:drug effects*; D013997:Time Factors; D014451:Ubiquinone / Q000031:analogs & derivatives / Q000737:chemistry
chemical_list: D005353:Fibronectins; D012333:RNA, Messenger; D014451:Ubiquinone; D000255:Adenosine Triphosphate; D003094:Collagen; C024989:coenzyme Q10