title: Effect of abamectin exposure on semen parameters indicative of reduced sperm maturity: a study on farmworkers in Antalya (Turkey).
abstract: Environmental exposure to pesticides may cause serious health risks including fertility and reproductive function. The aim of this study was to highlight whether there is a relationship between exposure to abamectin and male fertility parameters of farmworkers. Twenty male farmworkers who were using abamectin and 20 men not exposed to pesticides were recruited as experimental and control groups, respectively. Semen analysis, molecular markers of sperm maturity and serum reproductive hormone levels were evaluated. In experimental group, high plasma abamectin levels were detected. These men have decreased sperm motility. Moreover, diminished molecular markers of sperm maturity, such as decreased hyaluronic acid (HA) binding of sperm, increased numbers of aniline blue positive sperm and increased percentage of creatine kinase (CK) positive sperm, were observed in abamectin-exposed men. Their serum testosterone, LH and FSH levels did not change significantly. We conclude that exposure to abamectin may impair male fertility by effecting semen quality.
authors.affiliation: Department of Histology and Embryology, Akdeniz University, School of Medicine, Antalya, Turkey. cilerozenci@akdeniz.edu.tr
authors.forename: C
authors.initials: C
authors.lastname: Celik-Ozenci
authors.forename: A
authors.initials: A
authors.lastname: Tasatargil
authors.forename: M
authors.initials: M
authors.lastname: Tekcan
authors.forename: L
authors.initials: L
authors.lastname: Sati
authors.forename: E
authors.initials: E
authors.lastname: Gungor
authors.forename: M
authors.initials: M
authors.lastname: Isbir
authors.forename: M F
authors.initials: MF
authors.lastname: Usta
authors.forename: M E
authors.initials: ME
authors.lastname: Akar
authors.forename: F
authors.initials: F
authors.lastname: Erler
mesh_terms: D000328:Adult; D000383:Agriculture; D000782:Aneuploidy; D015415:Biomarkers / Q000378:metabolism; D016022:Case-Control Studies; D003402:Creatine Kinase / Q000378:metabolism; D012739:Gonadal Steroid Hormones / Q000097:blood; D006801:Humans; D007248:Infertility, Male / Q000139:chemically induced; D007559:Ivermectin / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000097:blood; D008297:Male; D016273:Occupational Exposure; D010575:Pesticides / Q000009:adverse effects* / Q000097:blood; D012661:Semen / Q000166:cytology* / Q000187:drug effects*; D013079:Sperm Maturation / Q000187:drug effects* / Q000235:genetics / Q000502:physiology; D014421:Turkey
chemical_list: D015415:Biomarkers; D012739:Gonadal Steroid Hormones; D010575:Pesticides; C048324:abamectin; D007559:Ivermectin; D003402:Creatine Kinase