title: Genetic polymorphisms of IL17A and pri-microRNA-938, targeting IL17A 3'-UTR, influence susceptibility to gastric cancer.
abstract: We report an association between gastric cancer (GC) and polymorphisms in IL17A, rs2275913 (-197 G > A), rs3748067 (*1249 C > T), and pri-miR-938, rs2505901 (T > C). We employed the multiplex PCR-SSCP method to detect gene polymorphisms in 337 GC cases and 587 controls. The minor allele frequency of rs2275913 was significantly higher, and those of rs3748067 and rs2505901 significantly lower, in GC cases than controls. The rs2275913 AA homozygote was associated with an increased risk (OR, 2.38; 95%CI, 1.63-3.46; p < 0.0001) for the development of both intestinal and diffuse types of GC. The rs3748067 T polymorphism was associated with a decreased risk for intestinal GC (OR, 0.511; 95%CI, 0.272-0.962; p = 0.037), whereas rs2505901 C locus carried a decreased risk overall for GC (OR, 0.733; 95%CI, 0.545-0.985; p = 0.039). In addition, rs3748067 T allele was inversely correlated with lymph node metastasis. Our results suggest that polymorphisms in both IL17A and pri-miR-938 contribute to cancer risk susceptibility and therefore can affect the development of gastric cancer.
authors.affiliation: Department of Gastroenterology, Kanazawa Medical University, 1-1 Daigaku, Uchinada-machi, Ishikawa 920-0293, Japan. tarisawa@kanazawa-med.ac.jp
authors.forename: Tomiyasu
authors.initials: T
authors.lastname: Arisawa
authors.forename: Tomomitsu
authors.initials: T
authors.lastname: Tahara
authors.forename: Hisakazu
authors.initials: H
authors.lastname: Shiroeda
authors.forename: Yasuhito
authors.initials: Y
authors.lastname: Matsue
authors.forename: Takahiro
authors.initials: T
authors.lastname: Minato
authors.forename: Tomoe
authors.initials: T
authors.lastname: Nomura
authors.forename: Hideto
authors.initials: H
authors.lastname: Yamada
authors.forename: Ranji
authors.initials: R
authors.lastname: Hayashi
authors.forename: Takashi
authors.initials: T
authors.lastname: Saito
authors.forename: Kazuhiro
authors.initials: K
authors.lastname: Matsunaga
authors.forename: Tomoki
authors.initials: T
authors.lastname: Fukuyama
authors.forename: Nobuhiko
authors.initials: N
authors.lastname: Hayashi
authors.forename: Toshimi
authors.initials: T
authors.lastname: Otsuka
authors.forename: Atsushi
authors.initials: A
authors.lastname: Fukumura
authors.forename: Masakatsu
authors.initials: M
authors.lastname: Nakamura
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Shibata
mesh_terms: D020413:3' Untranslated Regions / Q000235:genetics; D000368:Aged; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006801:Humans; D020381:Interleukin-17 / Q000235:genetics*; D008297:Male; D035683:MicroRNAs / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D012306:Risk; D013274:Stomach Neoplasms / Q000235:genetics* / Q000276:immunology
chemical_list: D020413:3' Untranslated Regions; D020381:Interleukin-17; D035683:MicroRNAs