title: Adaptive immunity is related to coronary artery disease severity after acute coronary syndrome in subjects with metabolic syndrome.
abstract: Metabolic syndrome (MetS) is an inflammatory state associated with high coronary disease risk. Inflammation and adaptive immunity modulate atherosclerosis and plaque instability. We examined early changes in anti-oxidized low-density lipoprotein (LDL) (anti-oxLDL) autoantibodies (Abs) in patients with MetS after an acute coronary syndrome (ACS). Patients of both genders (n=116) with MetS were prospectively included after an acute myocardial infarction (MI) or hospitalization due to unstable angina. Anti-oxLDL Abs (IgG class) were assayed at baseline, three and six weeks after ACS. The severity of coronary disease was evaluated by the Gensini score. We observed a decrease in anti-oxLDL Abs titers (p<0.002 vs. baseline), mainly in males (p=0.01), in those under 65 y (p=0.03), and in subjects with Gensini score above median (p=0.04). In conclusion, early decrease in circulating anti-oxLDL Abs is associated with coronary disease severity among subjects with MetS.
authors.affiliation: Cardiology Division, Department of Medicine, Federal University of São Paulo, SP, Brazil. mcoizar@terra.com.br
authors.forename: Maria C
authors.initials: MC
authors.lastname: Izar
authors.forename: Henrique A
authors.initials: HA
authors.lastname: Fonseca
authors.forename: Luiz F
authors.initials: LF
authors.lastname: Pinheiro
authors.forename: Carlos M
authors.initials: CM
authors.lastname: Monteiro
authors.forename: Rui M
authors.initials: RM
authors.lastname: Póvoa
authors.forename: Andréa M
authors.initials: AM
authors.lastname: Monteiro
authors.forename: Antonio M
authors.initials: AM
authors.lastname: Figueiredo-Neto
authors.forename: Magnus A
authors.initials: MA
authors.lastname: Gidlund
authors.forename: Francisco A
authors.initials: FA
authors.lastname: Fonseca
mesh_terms: D054058:Acute Coronary Syndrome / Q000150:complications / Q000276:immunology*; D056704:Adaptive Immunity; D000328:Adult; D000367:Age Factors; D000368:Aged; D000789:Angina, Unstable / Q000150:complications / Q000276:immunology; D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000150:complications / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008077:Lipoproteins, LDL / Q000276:immunology*; D008297:Male; D024821:Metabolic Syndrome / Q000150:complications / Q000276:immunology*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000276:immunology; D011446:Prospective Studies; D012720:Severity of Illness Index; D012737:Sex Factors
chemical_list: D001323:Autoantibodies; D008077:Lipoproteins, LDL; C099252:oxidized low density lipoprotein