title: [Histologic risk factors of basal cell carcinoma of the face, about 184 cases].
abstract: BACKGROUND
  Basal cell carcinoma is the most common type of skin cancer in humans.
  
  
  OBJECTIVE
  The aim of our study was to determine the histologic risk factors involved in recurrence of basal cell carcinomas of the face.
  
  
  METHODS
  We conducted a retrospective study of patients with primary basal cell carcinoma (BCC) of the face treated between March 2003 and December 2005. We analyzed the size of lateral and deep margins of tumor, histologic subtype, perineural invasion, and ulcerations. Clinical follow-up was observed until June 2011.
  
  
  RESULTS
  We note that 184 cases of BCC were included. Eleven recurrences occurred during the follow-up, i.e. 6%. The population was divided into two groups according to histologic safety margins (1 mm for all basal cell carcinomas, 0.8 mm for nodular and 2 mm for aggressive-growth (AG-BCC) subtypes). There was a significant difference between groups in regards to cancer recurrence. Tumor size above 2 cm and presence of perineural invasion increased the risk of recurrence.
  
  
  CONCLUSIONS
  Low histological safety margins appear to be critical on tumor recurrence. Depending on the tumor characteristics, and the patient, we advocate a re-excision in cases of histological safety margins inferior to 0.8 mm for the nodular subtypes and 2 mm for aggressive subtypes. Tumor size, and perineural invasion should be taken into consideration so as to make a well-informed decision between re-excision and a watching strategy in critical cases.
authors.affiliation: Service d'ophtalmologie, faculté de médecine Henri-Warembourg Lille, université Nord-de-France, hôpital Claude-Huriez, CHRU de Lille, France. owavreille@gmail.com
authors.forename: O
authors.initials: O
authors.lastname: Wavreille
authors.forename: E
authors.initials: E
authors.lastname: Martin De Lassalle
authors.forename: G
authors.initials: G
authors.lastname: Wavreille
authors.forename: L
authors.initials: L
authors.lastname: Mortier
authors.forename: V
authors.initials: V
authors.lastname: Martinot Duquennoy
mesh_terms: D000368:Aged; D002280:Basal Cell Carcinoma / Q000209:etiology* / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D005153:Facial Neoplasms / Q000209:etiology* / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000209:etiology / Q000401:mortality / Q000473:pathology / Q000601:surgery; D009381:Neoplasms, Radiation-Induced / Q000209:etiology / Q000401:mortality / Q000473:pathology / Q000601:surgery; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000209:etiology* / Q000401:mortality / Q000473:pathology* / Q000601:surgery*; D014466:Ultraviolet Rays / Q000009:adverse effects