title: Trichlorosilyl triflate-mediated enantioselective directed cross-aldol reaction between ketones using a chiral phosphine oxide as an organocatalyst.
abstract: Trichlorosilyl triflate-promoted directed cross-aldol reaction between ketones in the presence of a chiral phosphine oxide as an organocatalyst is described. This is the first enantioselective cross-aldol reaction between simple ketones with good enantioselectivity.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto, Japan.
authors.forename: Shohei
authors.initials: S
authors.lastname: Aoki
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Kotani
authors.forename: Masaharu
authors.initials: M
authors.lastname: Sugiura
authors.forename: Makoto
authors.initials: M
authors.lastname: Nakajima
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D002384:Catalysis; D007659:Ketones / Q000737:chemistry*; D008698:Mesylates / Q000737:chemistry*; D015394:Molecular Structure; D010720:Phosphines / Q000737:chemistry*; D012821:Silanes / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: D000447:Aldehydes; D007659:Ketones; D008698:Mesylates; D010720:Phosphines; D012821:Silanes; C116609:3-hydroxybutanal