title: Glycated albumin in patients with neonatal diabetes mellitus is apparently low in relation to glycemia compared with that in patients with type 1 diabetes mellitus.
abstract: BACKGROUND
  Although glycated albumin (GA) is a useful glycemic control marker in neonatal diabetes mellitus (NDM), there has been no report comparing GA levels between NDM patients and non-diabetic infants. Moreover, GA in NDM patients may be apparently low in relation to glycemia due to the assumed elevation of albumin metabolism in neonates.
  
  
  METHODS
  We compared GA levels between 6 patients with NDM and 18 non-diabetic infants or 14 patients with type 1 diabetes mellitus (T1DM). Mean blood glucose (MBG) was calculated on the basis of self-monitoring of blood glucose for 1 month before GA measurement.
  
  
  RESULTS
  GA in NDM patients was significantly higher than that in non-diabetic infants (22.0 ± 5.8 vs. 10.2 ± 1.4%; p < 0.0001), and GA levels significantly correlated with MBG in both NDM and T1DM patients. However, GA in NDM patients was significantly lower than in T1DM patients (25.8 ± 5.3%; p = 0.0046), whereas MBG in NDM patients was significantly higher than in T1DM patients (233 ± 79 vs. 183 ± 41 mg/dl; p = 0.0006).
  
  
  CONCLUSIONS
  GA levels in NDM patients were apparently low in relation to glycemia. Therefore, reference values for infants should be used for assessing the GA level in NDM.
authors.affiliation: Department of Pediatrics, Asahikawa Medical University, Asahikawa, Japan. shige5p@asahikawa-med.ac.jp
authors.forename: Shigeru
authors.initials: S
authors.lastname: Suzuki
authors.forename: Masafumi
authors.initials: M
authors.lastname: Koga
authors.forename: Hironori
authors.initials: H
authors.lastname: Takahashi
authors.forename: Kumihiro
authors.initials: K
authors.lastname: Matsuo
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Tanahashi
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Azuma
mesh_terms: D000293:Adolescent; D001786:Blood Glucose / Q000378:metabolism*; D002648:Child; D003920:Diabetes Mellitus / Q000097:blood*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D005260:Female; D017127:Glycation End Products, Advanced; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000097:blood*; D008297:Male; D012709:Serum Albumin / Q000378:metabolism*; D000093423:Glycated Serum Albumin
chemical_list: D001786:Blood Glucose; D017127:Glycation End Products, Advanced; D012709:Serum Albumin; D000093423:Glycated Serum Albumin