title: Association of multi-pathogenic infections with BAT2, CXCL12, Mx1 and EHMT2 variations in pigs.
abstract: Porcine reproductive and respiratory syndrome virus (PRRSV), Haemophilus parasuis and Pseudorabies become a widespread problem causing great economic losses associated with reproductive disturbance, respiratory diseases, neonatal mortality, fibrinous polyserositis, meningitis and arthritis in the pig industry. The important candidate genes are assumed to play crucial roles in host defense against the diseases. The aims of this study were to evaluate the variants in HLA-B associated transcript 2 (BAT2), CXCL12, myxovirus resistance protein 1 (Mx1) and EHMT2 genes and their effects on the risk of infection PRRSV and H. parasuis in a case-control (diseased-healthy pigs) population of Duroc × Landrace × LargeWhite. The results showed that the mutations in BAT2, Mx1 and EHMT2 genes were significantly associated with the antibody and the reisk of infection PRRSV and H. parasuis. Those individuals with AA genotype of BAT2 had significantly higher Pseudorabies virus antibody than that with GG and GA (P < 0.05), and the individuals with TT genotype of EHMT2 generated higher Hog Cholera and Pseudorabies virus antibody than that wtih GG and GA (P < 0.01). These results indicated that the polymorphisms in Mx1, BAT2 and EHMT2 genes changed the diseases susceptibility and could be the potential markers assisting the pig breeding selection and disease resistance.
authors.affiliation: Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, Huazhong Agriculture University, Wuhan 430070, Hubei, China.
authors.forename: S J
authors.initials: SJ
authors.lastname: Wang
authors.forename: W J
authors.initials: WJ
authors.lastname: Liu
authors.forename: L G
authors.initials: LG
authors.lastname: Yang
authors.forename: H B
authors.initials: HB
authors.lastname: Liu
authors.forename: C A
authors.initials: CA
authors.lastname: Sargent
authors.forename: N A
authors.initials: NA
authors.lastname: Affara
authors.forename: S J
authors.initials: SJ
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology; D000914:Antibodies, Viral / Q000276:immunology; D016022:Case-Control Studies; D054377:Chemokine CXCL12 / Q000235:genetics*; D060467:Disease Resistance / Q000235:genetics / Q000276:immunology; D019204:GTP-Binding Proteins / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006192:Haemophilus Infections / Q000662:veterinary; D011495:Histone-Lysine N-Methyltransferase / Q000235:genetics*; D015994:Incidence; D064547:Myxovirus Resistance Proteins; D020641:Polymorphism, Single Nucleotide; D019318:Porcine Reproductive and Respiratory Syndrome / Q000235:genetics / Q000276:immunology; D011557:Pseudorabies / Q000235:genetics / Q000276:immunology; D013552:Swine; D013553:Swine Diseases / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D000914:Antibodies, Viral; D054377:Chemokine CXCL12; D064547:Myxovirus Resistance Proteins; D011495:Histone-Lysine N-Methyltransferase; D019204:GTP-Binding Proteins