title: Salivary cortisol, 17β-estradiol, progesterone, dehydroepiandrosterone, and α-amylase in patients with burning mouth syndrome.
abstract: OBJECTIVE
  The aim of this study was to investigate salivary markers related with burning mouth syndrome (BMS).
  
  
  METHODS
  Thirty female patients with BMS and twenty female control subjects were included. Unstimulated (UWS) and stimulated whole saliva samples (SWS) were collected, and their flow rates were determined. Salivary levels of cortisol, 17β-estradiol, progesterone, dehydroepiandrosterone (DHEA), and enzymatic activity of α-amylase were determined. Salivary transferrin level was measured to determine the level of blood contamination in saliva samples.
  
  
  RESULTS
  The levels of all analytes in UWS were significantly correlated with those of SWS. The levels of 17β-estradiol, progesterone, and DHEA in UWS were significantly correlated with age. Age-matched comparisons revealed that the patient group had significantly higher levels of cortisol in UWS and of 17β-estradiol in SWS. When the patients were divided into older (≥60years) and younger (<60years) groups, the older group showed a significantly lower level of progesterone in UWS. There were no significant relationships between treatment efficacy and levels of salivary analytes.
  
  
  CONCLUSIONS
  In conclusion, patients with BMS showed significantly higher levels of cortisol in UWS and of 17β-estradiol in SWS compared with controls.
authors.affiliation: Department of Oral Medicine and Oral Diagnosis, School of Dentistry and Dental Research Institute, Seoul National University, Yunkeun-Dong, Chongro-Ku, Seoul, Korea.
authors.forename: H-Il
authors.initials: HI
authors.lastname: Kim
authors.forename: Y-Y
authors.initials: YY
authors.lastname: Kim
authors.forename: J-Y
authors.initials: JY
authors.lastname: Chang
authors.forename: J-Y
authors.initials: JY
authors.lastname: Ko
authors.forename: H-S
authors.initials: HS
authors.lastname: Kho
mesh_terms: D000367:Age Factors; D000368:Aged; D002054:Burning Mouth Syndrome / Q000097:blood / Q000378:metabolism* / Q000523:psychology; D016022:Case-Control Studies; D002998:Clonazepam / Q000627:therapeutic use; D003687:Dehydroepiandrosterone / Q000032:analysis*; D004958:Estradiol / Q000032:analysis*; D005260:Female; D005500:Follow-Up Studies; D018757:GABA Modulators / Q000627:therapeutic use; D006801:Humans; D006854:Hydrocortisone / Q000032:analysis*; D054327:Lubricants / Q000627:therapeutic use; D008875:Middle Aged; D011374:Progesterone / Q000032:analysis*; D012463:Saliva / Q000737:chemistry* / Q000378:metabolism; D012636:Secretory Rate / Q000502:physiology; D014168:Transferrin / Q000032:analysis; D016896:Treatment Outcome; D000516:alpha-Amylases / Q000032:analysis*
chemical_list: D018757:GABA Modulators; D054327:Lubricants; D014168:Transferrin; D003687:Dehydroepiandrosterone; D011374:Progesterone; D004958:Estradiol; D002998:Clonazepam; D000516:alpha-Amylases; D006854:Hydrocortisone