title: Prospects for gene transfer for clinical heart failure.
abstract: Congestive heart failure is an inexorable disease associated with unacceptably high morbidity and mortality. Preclinical results indicate that gene transfer using various proteins is a safe and effective approach for increasing function of the failing heart. In the current review, we provide a summary of cardiac gene transfer in general and summarize findings using adenylyl cyclase 6 as therapeutic gene in the failing heart. We also discuss the potential usefulness of a new treatment for congestive heart failure, paracrine-based gene transfer.
authors.affiliation: Department of Medicine, University of California San Diego, CA, USA.
authors.forename: T
authors.initials: T
authors.lastname: Tang
authors.forename: M H
authors.initials: MH
authors.lastname: Gao
authors.forename: H Kirk
authors.initials: HK
authors.lastname: Hammond
mesh_terms: D000262:Adenylyl Cyclases / Q000235:genetics*; D000375:Aging; D002118:Calcium / Q000378:metabolism; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D006333:Heart Failure / Q000201:enzymology / Q000628:therapy*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000235:genetics; D019899:Paracrine Communication
chemical_list: D007334:Insulin-Like Growth Factor I; D000262:Adenylyl Cyclases; C121100:adenylyl cyclase 6; D002118:Calcium