title: Monitoring HIV drug resistance using early warning indicators in China: results from a pilot survey conducted in 2008.
abstract: Robust programmatic monitoring of factors associated with the emergence of human immunodeficiency virus (HIV) drug resistance is an essential component of antiretroviral therapy (ART) program evaluation and treatment optimization. China piloted World Health Organization HIV drug resistance early warning indicators to assess the feasibility and usefulness of results. Overall, early warning indicator monitoring showed high levels of appropriate ART prescribing, low rates of loss to follow-up 12 months after ART initiation, and high rates of retention of first-line ART at 12 months. On-time drug pick-up, which may signal treatment interruptions, was identified as a challenge. HIV drug resistance early warning indicator monitoring provides a valuable assessment of ART service delivery, and its application will be scaled up throughout China.
authors.affiliation: Division of Treatment and Care, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China.
authors.forename: Ye
authors.initials: Y
authors.lastname: Ma
authors.forename: Fujie
authors.initials: F
authors.lastname: Zhang
authors.forename: Huiqin
authors.initials: H
authors.lastname: Li
authors.forename: Hao
authors.initials: H
authors.lastname: Wu
authors.forename: Jianbo
authors.initials: J
authors.lastname: Zhang
authors.forename: Yusheng
authors.initials: Y
authors.lastname: Ding
authors.forename: Decai
authors.initials: D
authors.lastname: Zhao
authors.forename: Hua
authors.initials: H
authors.lastname: Fang
authors.forename: Shuntai
authors.initials: S
authors.lastname: Zhou
authors.forename: Zhongfu
authors.initials: Z
authors.lastname: Liu
authors.forename: Lan
authors.initials: L
authors.lastname: Zhang
authors.forename: Connie
authors.initials: C
authors.lastname: Osborne
authors.forename: Nicole
authors.initials: N
authors.lastname: Seguy
authors.forename: Yan
authors.initials: Y
authors.lastname: Zhao
mesh_terms: D000328:Adult; D044966:Anti-Retroviral Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002681:China / Q000453:epidemiology; D015331:Cohort Studies; D003695:Delivery of Health Care; D024882:Drug Resistance, Viral; D015658:HIV Infections / Q000188:drug therapy* / Q000453:epidemiology*; D006305:Health Status Indicators; D006801:Humans; D059012:Lost to Follow-Up; D010865:Pilot Projects; D011159:Population Surveillance; D014944:World Health Organization; D016903:Drug Monitoring
chemical_list: D044966:Anti-Retroviral Agents