title: In vitro anti-glycation and anti-oxidant properties of synthesized Schiff bases.
abstract: A series of mono, bis and mixed Schiff bases (1-7) were synthesised and evaluated for potential anti-glycation and anti-oxidant activities using the bovine serum albumin-glucose assay and 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical assay respectively. All compounds showed significant (p<0.05) antiglycating activities with IC50 values (4.02x10(-24)±0.1-2.88x10(-1)±1.35 mM) which were lower than the standard positive control aminoguanidine (IC50: 1.51x10(-3)±2.11 mM). Moreover, compounds 1-7 were found to possess significant (p<0.05) DPPH radical scavenging properties with SC50 values (1.31x10(-19)±0.05 to 2.25x10(-1)±1.24 mM) lower than the standard ascorbic acid (SC50: 5.50x10(-3)±2.11 mM). Compound 6 was found to be the most potent anti-glycating molecule (IC50 value: 4.02x10(-24)±0.1 mM) while compound 5 was the most potent anti-oxidant molecule (SC50: 1.31x10(-19)±0.05 mM); both being significantly lower (p<0.05) than the respective positive controls used. The present data showed that the number of phenolic OH together with structural changes influence both the anti-glycation and anti-oxidant observed herein. This study provides for the first time a series of potential template molecules for possible pharmaceutical applications that warrant further investigation as potential anti-glycation and anti-oxidant agents which could be of importance in metabolic diseases including diabetes mellitus.
authors.affiliation: Department of Chemistry, Faculty of Science, University of Mauritius, Reduit, Mauritius.
authors.forename: Sabina
authors.initials: S
authors.lastname: Jhaumeer-Laulloo
authors.forename: Minu Gupta
authors.initials: MG
authors.lastname: Bhowon
authors.forename: Shabneez
authors.initials: S
authors.lastname: Mungur
authors.forename: Mohamad Fawzi
authors.initials: MF
authors.lastname: Mahomoodally
authors.forename: Anwar Hussein
authors.initials: AH
authors.lastname: Subratty
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000737:chemistry; D002417:Cattle; D016166:Free Radical Scavengers / Q000737:chemistry; D006031:Glycosylation / Q000187:drug effects; D015394:Molecular Structure; D010851:Picrates / Q000737:chemistry; D012545:Schiff Bases / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D012710:Serum Albumin, Bovine / Q000378:metabolism
chemical_list: D000975:Antioxidants; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D010851:Picrates; D012545:Schiff Bases; D012710:Serum Albumin, Bovine; C004931:1,1-diphenyl-2-picrylhydrazyl