title: Absolute configurations of integracins A, B, and 15'-dehydroxy-integracin B.
abstract: Integracins A (1) and B (2), potent HIV-1 integrase inhibitors, and 15'-dehydroxy-integracin B (3) were isolated for the first time from Chinese mangrove plant Sonneratia hainanensis. Their absolute configurations were determined by the Mosher's method and specific rotation analysis of alcohols (6 and 7) obtained from integracin A in two steps and by chemical correlation. Integracin A (1) also exhibited significant cytotoxicity against the tumor cell lines HepG2 and NCI-H460 with both 100% inhibitions at 25 µg/ml.
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, People's Republic of China.
authors.forename: Hai-Li
authors.initials: HL
authors.lastname: Liu
authors.forename: Xiao-Yin
authors.initials: XY
authors.lastname: Huang
authors.forename: Jia
authors.initials: J
authors.lastname: Li
authors.forename: Guo-Rong
authors.initials: GR
authors.lastname: Xin
authors.forename: Yue-Wei
authors.initials: YW
authors.lastname: Guo
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D056945:Hep G2 Cells; D006801:Humans; D019684:Magnoliopsida / Q000737:chemistry; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry; D012118:Resorcinols / Q000737:chemistry* / Q000494:pharmacology
chemical_list: C574907:15'-dehydroxy-integracin B; D000970:Antineoplastic Agents; D012118:Resorcinols; C574906:integracin A; C574908:integracin B