title: Cross-diagnostic comparison of duration mismatch negativity and P3a in bipolar disorder and schizophrenia.
abstract: OBJECTIVE
  Bipolar disorder and schizophrenia share common pathophysiological processes and may have similar perceptual abnormalities. Mismatch negativity (MMN) and P3a - event-related potentials associated with auditory preattentional processing - have been extensively studied in schizophrenia, but rarely in bipolar disorder. Furthermore, MMN and P3a have not been examined between diagnostic subgroups of patients with bipolar disorder. We evaluated MMN and P3a in patients with bipolar disorder compared to patients with schizophrenia and healthy controls.
  
  
  METHODS
  MMN and P3a were assessed in 52 bipolar disorder patients, 30 schizophrenia patients, and 27 healthy control subjects during a duration-deviant auditory oddball paradigm.
  
  
  RESULTS
  Significant MMN and P3a amplitude reductions were present in patients with bipolar disorder and schizophrenia relative to controls. The MMN reduction was more prominent in patients with schizophrenia than bipolar disorder, at a trend level. P3a did not differ significantly between patient groups. There were no MMN or P3a differences between patients with bipolar I (n = 34) and bipolar II (n = 18) disorder. Patients with bipolar I disorder failed to show lateralized MMN, in contrast to the other groups. No MMN or P3a differences were found between patients with bipolar disorder taking (n = 12) and not taking (n = 40) lithium, as well as between those taking (n = 30) and not taking (n = 22) antipsychotic medications.
  
  
  CONCLUSIONS
  Patients with bipolar disorder showed deficits in preattentive auditory processing, including MMN deficits that are less severe and P3a deficits that are slightly more pronounced, than those seen in schizophrenia.
authors.affiliation: Mental Illness Research, Education, and Clinical Center (MIRECC), VA Greater Los Angeles Healthcare System, Los Angeles, CA 90073, USA. caroljahshan@hotmail.com
authors.forename: Carol
authors.initials: C
authors.lastname: Jahshan
authors.forename: Jonathan K
authors.initials: JK
authors.lastname: Wynn
authors.forename: Kristopher I
authors.initials: KI
authors.lastname: Mathis
authors.forename: Lori L
authors.initials: LL
authors.lastname: Altshuler
authors.forename: David C
authors.initials: DC
authors.lastname: Glahn
authors.forename: Michael F
authors.initials: MF
authors.lastname: Green
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D000704:Analysis of Variance; D001714:Bipolar Disorder / Q000145:classification / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology*; D001931:Brain Mapping; D003265:Contingent Negative Variation / Q000187:drug effects / Q000502:physiology*; D004569:Electroencephalography; D018913:Event-Related Potentials, P300 / Q000187:drug effects / Q000502:physiology*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D018021:Lithium Chloride / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000175:diagnosis* / Q000503:physiopathology*
chemical_list: D018021:Lithium Chloride