title: Clinical effects of bovine lactoferrin on two canine cases with familial neutrophil dysfunction.
abstract: This study reported detailed clinical effects of bovine lactoferrin on 2 canine littermates (1 female and 1 male) with familial neutrophil dysfunction and an investigation of their genetic background. Clinical signs caused by severe upper respiratory bacterial infections were observed in these dogs. Oral administration of bovine lactoferrin for a long duration improved their clinical signs (severe uveitis in the female dog and coughing from pneumonia in the male dog). Their backcross dogs that have the same father didn't show clinical signs of bacterial infection. Neutrophil function tests revealed that the backcross dogs didn't have any disorders. It is likely that abnormal clinical signs are associated with neutrophil dysfunction in the colony, and the mother dog of these cases might be the genetic carrier of this dysfunction.
authors.affiliation: Department of Veterinary Medicine, Iwate University, 3-18-8 Ueda, Morioka, Iwate 020-8550, Japan. reekos@iwate-u.ac.jp
authors.forename: Reeko
authors.initials: R
authors.lastname: Sato
authors.forename: Saori
authors.initials: S
authors.lastname: Kobayashi
authors.forename: Yuya
authors.initials: Y
authors.lastname: Abe
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kamishina
authors.forename: Shinichi
authors.initials: S
authors.lastname: Oda
authors.forename: Jun
authors.initials: J
authors.lastname: Yasuda
authors.forename: Juso
authors.initials: J
authors.lastname: Sasaki
mesh_terms: D000818:Animals; D002417:Cattle; D004283:Dog Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000235:genetics / Q000276:immunology*; D004285:Dogs; D005260:Female; D007154:Immune System Diseases / Q000188:drug therapy / Q000235:genetics / Q000662:veterinary*; D007781:Lactoferrin / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D009504:Neutrophils / Q000187:drug effects* / Q000276:immunology; D010375:Pedigree; D011859:Radiography; D012141:Respiratory Tract Infections / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000662:veterinary*
chemical_list: D007781:Lactoferrin