title: Activated microglial cells synthesize and secrete AGE-albumin.
abstract: A holy grail of curing neurodegenerative diseases is to identify the main causes and mechanisms underlying neuronal death. Many studies have sought to identify these targets in a wide variety of ways, but a more important task is to identify critical molecular targets and their origins. Potential molecular targets include advanced glycation end products (AGEs) that can promote neuronal cell death, thereby contributing to neurodegenerative disorders such as Alzheimer disease or Parkinson disease. In this study, we showed that AGE-albumin (glycated albumin) is synthesized in microglial cells and secreted in the human brain. Our results provide new insight into which microglial cells can promote the receptor for AGE-mediated neuronal cell death, eventually leading to neurodegenerative diseases.
authors.affiliation: Center for Genomics and Proteomics, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon, Korea.
authors.forename: Kyunghee
authors.initials: K
authors.lastname: Byun
authors.forename: Enkhjaigal
authors.initials: E
authors.lastname: Bayarsaikhan
authors.forename: Daesik
authors.initials: D
authors.lastname: Kim
authors.forename: Myeongjoo
authors.initials: M
authors.lastname: Son
authors.forename: Junhee
authors.initials: J
authors.lastname: Hong
authors.forename: Goo-Bo
authors.initials: GB
authors.lastname: Jeong
authors.forename: Sun Ha
authors.initials: SH
authors.lastname: Paek
authors.forename: Moo-Ho
authors.initials: MH
authors.lastname: Won
authors.forename: Bonghee
authors.initials: B
authors.lastname: Lee