title: May long term oxcarbazepine treatment be lead to secondary hyperparathyroidism?
abstract: OBJECTIVE
  The adverse effects of newer antiepileptic drugs are not well-known. This study assessed the impact of oxcarbazepine (OXC) treatment on bone turnover.
  
  
  METHODS
  Forty-four children with idiopathic focal (and/or secondarily generalized) epilepsy who had been treated with OXC for more than 1 year were compared with 33 healthy, age- and sex-matched children. Serum calcium, phosphorus, alkaline phosphatase, parathyroid hormone, osteocalcin, calcitonin, and 25-hydroxyvitamin D, and bone mineral density were measured to evaluate and compare bone mineralization between the two groups.
  
  
  RESULTS
  The serum levels of calcium, osteocalcin, 25-hydroxyvitamin D, and bone mineral density did not differ significantly between the study and control groups. However, serum levels of parathyroid hormone, alkaline phosphatase, phosphorus, and calcitonin differed significantly between the two groups.
  
  
  CONCLUSIONS
  These findings suggest that OXC treatment leads to secondary hyperparathyroidism with high-turnover bone disease and/or impaired intestinal calcium absorption.
authors.affiliation: Department of Pediatrics, Gulhane Military Medical Faculty, Etlik, Ankara, Turkey.
authors.forename: O
authors.initials: O
authors.lastname: Babacan
authors.forename: A
authors.initials: A
authors.lastname: Karaoglu
authors.forename: S
authors.initials: S
authors.lastname: Vurucu
authors.forename: E
authors.initials: E
authors.lastname: Yesilkaya
authors.forename: O
authors.initials: O
authors.lastname: Yesilyurt
authors.forename: T
authors.initials: T
authors.lastname: Cayci
authors.forename: M
authors.initials: M
authors.lastname: Gulgun
authors.forename: B
authors.initials: B
authors.lastname: Unay
authors.forename: R
authors.initials: R
authors.lastname: Akın
authors.forename: O
authors.initials: O
authors.lastname: Ozcan