title: Scavenger receptor for hemoglobin in preterm prelabor rupture of membranes pregnancies complicated by histological chorioamnionitis.
abstract: OBJECTIVE
  We sought to evaluate the distribution of scavenger receptor for hemoglobin positive (CD163(+)) cells in the placenta and fetal membranes from pregnancies complicated by preterm prelabor rupture of membranes with respect to the presence and absence of histological chorioamnionitis.
  
  
  METHODS
  Sixty-two women with singleton pregnancies with a gestational age between 24+0 and 36+6 weeks were included in a prospective cohort study. CD163 was evaluated by immunohistochemistry in the placenta and fetal membranes. The number of CD163(+) cells and neutrophils was counted in the following locations: fetal membranes' amnion, chorion, and decidua, as well as the placenta's amnion, chorionic plate, subchorionic fibrin, stem villi, terminal villi, and decidua.
  
  
  RESULTS
  CD163(+) cells were found in all compartments of the placenta and the fetal membranes regardless of the inflammatory status. A positive correlation between the number of CD163(+) cells and neutrophils in the subchorionic fibrin and the chorionic plate was found. The number of CD163(+) cells was higher in the placental subchorionic fibrin and chorionic plate when histological chorioamnionitis was present.
  
  
  CONCLUSIONS
  The presence of histological chorioamnionitis affected the number of CD163(+) cells in the placental chorionic plate and in the subchorionic fibrin but not in the fetal membranes.
authors.affiliation: Department of Obstetrics and Gynecology, Charles University in Prague, Faculty of Medicine Hradec Kralove, Biomedical Reseach Center, University Hospital Hradec Kralove, Czech Republic.
authors.forename: Marian
authors.initials: M
authors.lastname: Kacerovsky
authors.forename: Teresa
authors.initials: T
authors.lastname: Cobo
authors.forename: Helena
authors.initials: H
authors.lastname: Hornychova
authors.forename: Ctirad
authors.initials: C
authors.lastname: Andrys
authors.forename: Ales
authors.initials: A
authors.lastname: Ryska
authors.forename: Ivana
authors.initials: I
authors.lastname: Musilova
authors.forename: Jaroslav Thierry
authors.initials: JT
authors.lastname: Kriz
authors.forename: Milan
authors.initials: M
authors.lastname: Kostal
authors.forename: Bo
authors.initials: B
authors.lastname: Jacobsson
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000378:metabolism*; D015214:Antigens, Differentiation, Myelomonocytic / Q000378:metabolism*; D002821:Chorioamnionitis / Q000378:metabolism* / Q000473:pathology; D015331:Cohort Studies; D005321:Extraembryonic Membranes / Q000378:metabolism / Q000473:pathology; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000378:metabolism* / Q000473:pathology; D005865:Gestational Age; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D010920:Placenta / Q000378:metabolism* / Q000473:pathology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism / Q000473:pathology; D011956:Receptors, Cell Surface / Q000378:metabolism*; D051116:Receptors, Scavenger / Q000378:metabolism; D014018:Tissue Distribution; D055815:Young Adult; D000098902:CD163 Antigen
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D000098902:CD163 Antigen; D006454:Hemoglobins; D011956:Receptors, Cell Surface; D051116:Receptors, Scavenger