title: Two new antimicrobial metabolites from the endophytic fungus, Seimatosporium sp.
abstract: Two new acaranoic acids, named seimatoporic acid A and B (1, and 2), together with six known compounds, R-(-)-mellein (3), cis-4-hydroxymellein (4), trans-4-hydroxymellein (5), 4R-hydroxy-5-methylmellein (6), (-)-5-hydroxymethylmellein (7), and ergosterol (8) were isolated from an endophytic fungus, Seimatosporium sp, by a bioassay-guided procedure. The structures of the new compounds have been assigned from analysis of the 1H and 13C NMR spectra, DEPT, and by 2D COSY, HMQC, HMBC and NOESY experiments. A mixture of compounds 1 and 2 showed strong antifungal activity against Botrytis cinerea, Septoria tritici, and Pyricularia oryzae.
authors.affiliation: Department Chemie, Universität Paderborn, Warburger Strasse 100, 33098 Paderborn, Germany.
authors.forename: Hidayat
authors.initials: H
authors.lastname: Hussain
authors.forename: Karsten
authors.initials: K
authors.lastname: Krohn
authors.forename: Barbara
authors.initials: B
authors.lastname: Schulz
authors.forename: Siegfried
authors.initials: S
authors.lastname: Draeger
authors.forename: Mamona
authors.initials: M
authors.lastname: Nazir
authors.forename: Muhammad
authors.initials: M
authors.lastname: Saleem
mesh_terms: D000890:Anti-Infective Agents / Q000302:isolation & purification*; D060026:Endophytes / Q000737:chemistry / Q000378:metabolism; D031666:Epilobium / Q000382:microbiology; D049934:Isocoumarins / Q000737:chemistry* / Q000302:isolation & purification*; D008826:Microbial Sensitivity Tests; D013098:Xylariales / Q000737:chemistry* / Q000378:metabolism
chemical_list: D000890:Anti-Infective Agents; D049934:Isocoumarins; C572155:seimatoporic acid A; C572156:seimatoporic acid B