title: Cycloartane triterpenoids from the stems of Schisandra glaucescens and their bioactivity.
abstract: Five new cycloartane triterpenoids, schiglausins K-O (1-5), including one hexanortriterpenoid (1) and one octanortriterpenoid (2), as well as two known compounds (6-7), were isolated from the stems of Schisandra glaucescens Diels. Their structures were elucidated on the basis of spectroscopic methods, including extensive NMR spectra. Compounds 2-7 were tested for their FXR agonistic and antagonistic effects. Compound 7 exhibited significant antagonistic effect against FXR with IC(50) of 1.50 μM.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Yunnan, People's Republic of China.
authors.forename: Juan
authors.initials: J
authors.lastname: Zou
authors.forename: Jing
authors.initials: J
authors.lastname: Jiang
authors.forename: Yan-Yan
authors.initials: YY
authors.lastname: Diao
authors.forename: Li-Bin
authors.initials: LB
authors.lastname: Yang
authors.forename: Jin
authors.initials: J
authors.lastname: Huang
authors.forename: Hong-Lin
authors.initials: HL
authors.lastname: Li
authors.forename: Xue
authors.initials: X
authors.lastname: Du
authors.forename: Wei-Lie
authors.initials: WL
authors.lastname: Xiao
authors.forename: Jian-Xin
authors.initials: JX
authors.lastname: Pu
authors.forename: Han-Dong
authors.initials: HD
authors.lastname: Sun
mesh_terms: D006801:Humans; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D018547:Plant Stems / Q000737:chemistry; D018160:Receptors, Cytoplasmic and Nuclear / Q000037:antagonists & inhibitors*; D032141:Schisandra / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000099150:Receptor, Farnesoid X-Activated
chemical_list: D010936:Plant Extracts; D018160:Receptors, Cytoplasmic and Nuclear; D014315:Triterpenes; D000099150:Receptor, Farnesoid X-Activated; C085352:cycloartane