title: Rho GDP-dissociation inhibitor alpha is associated with cancer metastasis in colon and prostate cancer.
abstract: Since metastasis is one of the most important prognostic factors in colorectal cancer, development of new methods to diagnose and prevent metastasis is highly desirable. However, the molecular mechanisms leading to the metastatic phenotype have not been well elucidated. In this study, a proteomics-based search was carried out for metastasis-related proteins in colorectal cancer by analyzing the differential expression of proteins in primary versus metastasis focus-derived colorectal tumor cells. Protein expression profiles were determined using a tissue microarray (TMA), and the results identified Rho GDP-dissociation inhibitor alpha (Rho GDI) as a metastasis-related protein in colon and prostate cancer patients. Consequently, Rho GDI may be useful as a diagnostic biomarker and/or a therapeutic to prevent colon and prostate cancer metastasis.
authors.affiliation: Laboratory of Biopharmaceutical Research, National Institute of Biomedical Innovation, Graduate School of Pharmaceutical Sciences Osaka University, Osaka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yamashita
authors.forename: T
authors.initials: T
authors.lastname: Okamura
authors.forename: K
authors.initials: K
authors.lastname: Nagano
authors.forename: S
authors.initials: S
authors.lastname: Imai
authors.forename: Y
authors.initials: Y
authors.lastname: Abe
authors.forename: H
authors.initials: H
authors.lastname: Nabeshi
authors.forename: T
authors.initials: T
authors.lastname: Yoshikawa
authors.forename: Y
authors.initials: Y
authors.lastname: Yoshioka
authors.forename: H
authors.initials: H
authors.lastname: Kamada
authors.forename: Y
authors.initials: Y
authors.lastname: Tsutsumi
authors.forename: S
authors.initials: S
authors.lastname: Tsunoda
mesh_terms: D000368:Aged; D015153:Blotting, Western; D045744:Cell Line, Tumor; D002851:Chromatography, High Pressure Liquid; D003110:Colonic Neoplasms / Q000556:secondary*; D015180:Electrophoresis, Gel, Two-Dimensional; D005456:Fluorescent Dyes; D005782:Gels; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000378:metabolism; D020730:Guanine Nucleotide Dissociation Inhibitors / Q000502:physiology*; D006801:Humans; D006868:Hydrolysis; D007150:Immunohistochemistry; D008297:Male; D013058:Mass Spectrometry; D046228:Microarray Analysis; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000556:secondary*; D014357:Trypsin / Q000737:chemistry; D062947:rho-Specific Guanine Nucleotide Dissociation Inhibitors
chemical_list: D005456:Fluorescent Dyes; D005782:Gels; D020730:Guanine Nucleotide Dissociation Inhibitors; D062947:rho-Specific Guanine Nucleotide Dissociation Inhibitors; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases; D014357:Trypsin