title: Expression and roles of NUPR1 in cholangiocarcinoma cells.
abstract: Nuclear protein-1 (NUPR1) is a small nuclear protein that is responsive to various stress stimuli. Although NUPR1 has been associated with cancer development, its expression and roles in cholangiocarcinoma have not yet been described. In the present study, we found that NUPR1 was over-expressed in human cholangiocarcinoma tissues, using immunohistochemistry. The role of NUPR1 in cholangiocarcinoma was examined by its specific siRNA. NUPR1 siRNA decreased proliferation, migration and invasion of human cholangiocarcinoma cell lines (HuCCT1 and SNU1196 cells). From these results, we conclude that NUPR1 is over-expressed in cholangiocarcinoma and regulates the proliferation and motility of cancer cells.
authors.affiliation: Department of Anatomy, Pusan National University School of Medicine, Yangsan, Korea.
authors.forename: Ki-Sun
authors.initials: KS
authors.lastname: Kim
authors.forename: Du-Il
authors.initials: DI
authors.lastname: Jin
authors.forename: Sik
authors.initials: S
authors.lastname: Yoon
authors.forename: Sun-Yong
authors.initials: SY
authors.lastname: Baek
authors.forename: Bong-Seon
authors.initials: BS
authors.lastname: Kim
authors.forename: Sae-Ock
authors.initials: SO
authors.lastname: Oh