title: [The clinical course of a three year-old girl after overdose of valproic acid].
abstract: Valproic acid (VA) is an antiepileptic drug, and frequently prescribed in pediatrics. VA overdose results in central nervous system depression, insufficient respiration, tachycardia, hypotension, hepatotoxicity, and electrolyte derangement. We describe the clinical course of a three year-old girl after accidental intake of 6,000 mg VA. Treatment included activated charcoal. Clinical observation included measurements of blood pressure, cardiac telemetry, and measurements of serum VA and metabolic parameters every 4-6 hrs. The girl was discharged successfully after 72 hrs with her usual dose of VA.
authors.affiliation: Klinisk Farmakologisk Afdeling, Bispebjerg Hospital, Bispebjerg Bakke 23, 2400 København NV, Denmark. thalia@dadlnet.dk
authors.forename: Thalia Marie
authors.initials: TM
authors.lastname: Blicher
authors.forename: Esben Thyssen
authors.initials: ET
authors.lastname: Vestergaard
authors.forename: Kim Peder
authors.initials: KP
authors.lastname: Dalhoff
mesh_terms: D000927:Anticonvulsants / Q000008:administration & dosage / Q000506:poisoning*; D000931:Antidotes / Q000627:therapeutic use; D002606:Charcoal / Q000627:therapeutic use; D002675:Child, Preschool; D062787:Drug Overdose / Q000188:drug therapy; D005260:Female; D006801:Humans; D014635:Valproic Acid / Q000008:administration & dosage / Q000506:poisoning*
chemical_list: D000927:Anticonvulsants; D000931:Antidotes; D002606:Charcoal; D014635:Valproic Acid