title: Intramolecular free-radical cyclization reactions on pentose sugars for the synthesis of carba-LNA and carba-ENA and the application of their modified oligonucleotides as potential RNA targeted therapeutics.
authors.affiliation: Chemical Biology Program, Department of Cell and Molecular Biology, Biomedical Center, Uppsala University, Sweden.
authors.forename: Chuanzheng
authors.initials: C
authors.lastname: Zhou
authors.forename: Jyoti
authors.initials: J
authors.lastname: Chattopadhyaya
mesh_terms: D000818:Animals; D001483:Base Sequence; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D003500:Cyclization; D005609:Free Radicals / Q000737:chemistry*; D006801:Humans; D058990:Molecular Targeted Therapy; D009841:Oligonucleotides / Q000138:chemical synthesis* / Q000737:chemistry* / Q000235:genetics; D010429:Pentoses / Q000737:chemistry*; D012313:RNA / Q000737:chemistry / Q000378:metabolism*
chemical_list: D005609:Free Radicals; D009841:Oligonucleotides; D010429:Pentoses; C477371:locked nucleic acid; D012313:RNA