title: Muscle-specific kinase-antibody-positive myasthenia gravis after autologous bone marrow transplantation.
abstract: A 44-year-old man presented with oculobulbar weakness approximately 5 years after autologous bone marrow transplantation (BMT). His workup led to the diagnosis of muscle-specific kinase-antibody-related myasthenia gravis (MG). There has been only one case report of muscle-specific kinase-antibody-positive MG after BMT, which was allogeneic. We report the first case of autologous BMT-associated MG with muscle-specific kinase antibody. The pathogenic mechanisms of immune dysregulation leading to MG after BMT are discussed.
authors.affiliation: Department of Neurology, Henry Ford Hospital, Detroit, MI, USA. kgrover1@hfhs.org
authors.forename: Kavita Mohindra
authors.initials: KM
authors.lastname: Grover
authors.forename: Naganand
authors.initials: N
authors.lastname: Sripathi
authors.forename: Stanton Bernard
authors.initials: SB
authors.lastname: Elias
mesh_terms: D000328:Adult; D000906:Antibodies / Q000097:blood*; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D004576:Electromyography; D006801:Humans; D008297:Male; D009157:Myasthenia Gravis / Q000097:blood / Q000209:etiology / Q000276:immunology; D009431:Neural Conduction / Q000502:physiology; D009460:Neurologic Examination; D016601:RNA-Binding Proteins / Q000276:immunology*; D014182:Transplantation, Autologous / Q000009:adverse effects
chemical_list: D000906:Antibodies; C493663:MBNL1 protein, human; D016601:RNA-Binding Proteins