title: Naked and self-clickable propargylic-decorated single-chain nanoparticle precursors via redox-initiated RAFT polymerization.
abstract: Protection of acetylenic monomers is a common practice to avoid parasitic side reactions during polymerization. Herein, we report that redox-initiated RAFT polymerization allows the direct, room temperature synthesis of a variety of single-chain nanoparticle precursors (displaying narrow molecular weight dispersity, M[overline](W)/M[overline](n) = 1.12 -1.37 up to M[overline](W) = 100 kDa) containing well-defined amounts of naked, unprotected acetylenic functional groups available for rapid and quantitative intrachain cross-linking via metal-catalyzed carbon-carbon coupling (i.e., C-C "click" chemistry). To illustrate the useful "self-clickable" character of the new unprotected acetylenic precursors, single-chain nanoparticles have been prepared for the first time in a facile and highly efficient manner by copper-catalyzed alkyne homocoupling (i.e., Glaser-Hay coupling) at room temperature under normal air atmosphere.
authors.affiliation: Centro de Física de Materiales (CSIC, UPV/EHU) - Materials Physics Center, Paseo Manuel de Lardizábal 5, 20018 San Sebastián, Spain.
authors.forename: Ana
authors.initials: A
authors.lastname: Sanchez-Sanchez
authors.forename: Isabel
authors.initials: I
authors.lastname: Asenjo-Sanz
authors.forename: Lorea
authors.initials: L
authors.lastname: Buruaga
authors.forename: José A
authors.initials: JA
authors.lastname: Pomposo
mesh_terms: D057930:Click Chemistry; D015394:Molecular Structure; D053758:Nanoparticles / Q000737:chemistry*; D010084:Oxidation-Reduction; D058105:Polymerization; D019904:Polymethyl Methacrylate / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D019904:Polymethyl Methacrylate