title: [Pathological grading analysis of liver biopsies in chronic hepatitis B virus carriers of different age ranges].
abstract: OBJECTIVE
  To study the best time of taking liver biopsy for chronic HBV carriers of age ranges and then guiding antiretroviral treatment.
  
  
  METHODS
  The liver biopsy pathologic results of 292 cases of chronic HBV carriers were collected from the First Affiliated Hospital of Kunming Medical College. The patients were divided into three groups according to ages. The differences between groups were compared by calculating the ratio of inflammation above G2 or fibrosis staging above S2.
  
  
  RESULTS
  The percentages of the chronic HBV carriers with liver histopathology inflammation graded above G2 or fibrosis staging above S2 were 26.5% (36/136) in 11 to 29 year-old group, 39.4% (37/94) in 30-39 year-old group and 58.1% (36/62) in 40-60 year-old group. Significant difference existed among groups in general (P less than 0.01). 39.4% (37/94) of chronic HBV carriers were found with inflammation graded above G2 or fibrosis staging above S2 in 30-39 year-old group, no statistically significant difference found between group 30-39 years old and group and 40-60 years old 58.1% (36/62) (P less than 0.01). 26.5% (36/136) of chronic HBV carriers under 30 years old were with inflammation graded above G2 or fibrosis staging above S2 as compared with the percentage of 46.8% (73/156) in the chronic HBV carriers over 30 years old group, and significant difference existed between the two groups (P less than 0.01).
  
  
  CONCLUSIONS
  The best time choice of taking liver biopsy should be at the ages elder than or equal to 30.
authors.affiliation: Department of Infectious Diseases, the First Affiliated Hospital of Kunming Medical College, Kunming 650032, China.
authors.forename: Chun-xia
authors.initials: CX
authors.lastname: Yang
authors.forename: Wei-bo
authors.initials: WB
authors.lastname: Yang
authors.forename: Jing-hua
authors.initials: JH
authors.lastname: Fan
authors.forename: Yi-hui
authors.initials: YH
authors.lastname: Chen
authors.forename: Yan-mei
authors.initials: YM
authors.lastname: Zhang
authors.forename: Ju
authors.initials: J
authors.lastname: Zhou
authors.forename: Xiao-wei
authors.initials: XW
authors.lastname: Chi
authors.forename: Li
authors.initials: L
authors.lastname: Xu
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D001706:Biopsy; D002648:Child; D005260:Female; D019694:Hepatitis B, Chronic / Q000473:pathology*; D006801:Humans; D008099:Liver / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D055815:Young Adult