title: Formulation factors affecting the release of ezetimibe from different liquisolid compacts.
abstract: BACKGROUND
  Liquisolid technique is one of the methods used to improve the dissolution rate of the poorly water soluble drugs utilizing non volatile liquids.
  
  
  OBJECTIVE
  Enhancement of the release of ezetimibe from different liquisolid formulations.
  
  
  METHODS
  Four liquid vehicles were used to prepare the liquid medications with different drug concentrations. The interaction between the drug and the excipients in liquisolid powders were characterized by DSC, X-ray, FTIR and SEM. Furthermore, the powder characteristics were evaluated by Carr's Index and powder wetting time determinations, respectively. All prepared formulations were compressed at different pressures to end with the same constant porosity and the tablets were evaluated by different tests and compared with conventional formula.
  
  
  CONCLUSIONS
  No interaction had been detected in all liquisolid formulations as shown in the results of XRD, FTIR, DSC and SEM. In addition to that, all liquisolid compacts had expressed faster dissolution profiles compared with that of conventional formula.
  
  
  CONCLUSIONS
  The dissolution rate was affected by the drug concentration, solubility of the drug in the liquid vehicle and type of carrier. In addition, the presence of the liquid vehicle has been found to affect the mechanical properties of the liquisolid formulations.
authors.affiliation: Department of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, Jordan. mskhanfar@just.edu.jo
authors.forename: M
authors.initials: M
authors.lastname: Khanfar
authors.forename: M
authors.initials: M
authors.lastname: Sheikh Salem
authors.forename: R
authors.initials: R
authors.lastname: Hawari
mesh_terms: D001384:Azetidines / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical / Q000379:methods; D004339:Drug Compounding / Q000379:methods; D005079:Excipients / Q000737:chemistry; D000069438:Ezetimibe; D050866:Liquid Crystals / Q000737:chemistry*; D016062:Porosity; D011208:Powders / Q000737:chemistry; D012995:Solubility; D013607:Tablets / Q000737:chemistry
chemical_list: D001384:Azetidines; D005079:Excipients; D011208:Powders; D013607:Tablets; D000069438:Ezetimibe