title: Intra coronary freshly isolated bone marrow cells transplantation improve cardiac function in patients with ischemic heart disease.
abstract: BACKGROUND
  Autologous bone marrow cell transplantation (BMCs-Tx) is a promising novel option for treatment of cardiovascular disease. In this study we analyzed whether intracoronary autologous freshly isolated BMCs-Tx have beneficial effects on cardiac function in patients with ischemic heart disease (IHD).
  
  
  RESULTS
  In this prospective nonrandomized study we treated 12 patients with IHD by freshly isolated BMCs-Tx by use of point of care system and compared them with a representative 12 control group without cell therapy. Global ejection fraction (EF) and infarct size area were determined by left ventriculography.Intracoronary transplantation of autologous freshly isolated BMCs led to a significant reduction of infarct size (p < 0.001) and an increase of global EF (p = 0.003) as well as infarct wall movement velocity (p < 0.001) after 6 months follow-up compared to control group. In control group there were no significant differences of global EF, infarct size and infarct wall movement velocity between baseline and 6 months after coronary angiography. Furthermore, we found significant decrease in New York Heart Association (NYHA) as well as significant decrease of B-type natriuretic peptide (BNP) level 6 months after intracoronary cell therapy (p < 0.001), whereas there were no significant differences in control group 6 months after coronary angiography.
  
  
  CONCLUSIONS
  These results demonstrate that intracoronary transplantation of autologous freshly isolated BMCs by use of point of care system is safe and may lead to improvement of cardiac function in patients with IHD.
  
  
  BACKGROUND
  
  
  
  BACKGROUND
  ISRCTN54510226.
authors.affiliation: Department of Internal Medicine, Division of Cardiology, Rostock-University, Ernst Hydemann Str 6, Rostock 18055, Germany.
authors.forename: Ilkay
authors.initials: I
authors.lastname: Bozdag-Turan
authors.forename: R Goekmen
authors.initials: RG
authors.lastname: Turan
authors.forename: Sophie
authors.initials: S
authors.lastname: Ludovicy
authors.forename: Ibrahim
authors.initials: I
authors.lastname: Akin
authors.forename: Stephan
authors.initials: S
authors.lastname: Kische
authors.forename: Henrik
authors.initials: H
authors.lastname: Schneider
authors.forename: Tim C
authors.initials: TC
authors.lastname: Rehders
authors.forename: C Hakan
authors.initials: CH
authors.lastname: Turan
authors.forename: Nicole S
authors.initials: NS
authors.lastname: Arsoy
authors.forename: Tina
authors.initials: T
authors.lastname: Hermann
authors.forename: Liliya
authors.initials: L
authors.lastname: Paranskaya
authors.forename: Jasmin
authors.initials: J
authors.lastname: Ortak
authors.forename: Peter
authors.initials: P
authors.lastname: Kohlschein
authors.forename: Manuela
authors.initials: M
authors.lastname: Bastian
authors.forename: Kurtulus
authors.initials: K
authors.lastname: Sahin
authors.forename: Christoph A
authors.initials: CA
authors.lastname: Nienaber
authors.forename: Hueseyin
authors.initials: H
authors.lastname: Ince
mesh_terms: D000368:Aged; D015415:Biomarkers / Q000097:blood; D016026:Bone Marrow Transplantation; D002469:Cell Separation / Q000379:methods; D017023:Coronary Angiography; D005260:Female; D005858:Germany; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D009203:Myocardial Infarction / Q000097:blood / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D017202:Myocardial Ischemia / Q000097:blood / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D009206:Myocardium / Q000473:pathology; D020097:Natriuretic Peptide, Brain / Q000097:blood; D019095:Point-of-Care Systems; D011446:Prospective Studies; D020127:Recovery of Function; D013318:Stroke Volume; D013997:Time Factors; D014182:Transplantation, Autologous; D016896:Treatment Outcome; D016277:Ventricular Function, Left
chemical_list: D015415:Biomarkers; D020097:Natriuretic Peptide, Brain