title: Osseous reaction to implantation of two endodontic cements: Mineral trioxide aggregate (MTA) and calcium enriched mixture (CEM).
abstract: OBJECTIVE
  The aim of the present in vivo study was to determine bone tissue reaction to calcium enriched mixture (CEM) and mineral trioxide aggregate (MTA) using a rat femur model.
  
  
  METHODS
  Sixty-three rats were selected and randomly divided into three groups of 21 each [experimental groups (n=15), control (n=6)]. Implantation cavities were prepared in each femoral bone and randomly filled with the biomaterials only in the experimental groups. The animals in three groups were sacrificed 1, 4, and 8 weeks postoperatively. Histologic evaluations comprising inflammation severity and new bone formation were blindly made on H&E-stained decalcified 6-µm sections.
  
  
  RESULTS
  At 1, 4, and 8 weeks after implantation number of inflammatory cells had decreased in the CEM, MTA and control groups, respectively, with no statistically significant differences. Conversely, new bone formation had increased in all the experimental and control groups, without statistically significant differences.
  
  
  CONCLUSIONS
  The results suggest that biocompatibility of MTA, as gold standard, and CEM cement as a new endodontic biomaterial are comparable.
authors.affiliation: Dental and Periodontal Research Center, Department of Endodontics, Faculty of Dentistry, Tabriz University of Medical Sciences, Golgasht Street, 5166614713, Tabriz, Iran.
authors.forename: Saeed
authors.initials: S
authors.lastname: Rahimi
authors.forename: Hadi
authors.initials: H
authors.lastname: Mokhtari
authors.forename: Shahriar
authors.initials: S
authors.lastname: Shahi
authors.forename: Ali
authors.initials: A
authors.lastname: Kazemi
authors.forename: Saeed
authors.initials: S
authors.lastname: Asgary
authors.forename: Mohammad-Jafar
authors.initials: MJ
authors.lastname: Eghbal
authors.forename: Mehran
authors.initials: M
authors.lastname: Mesgariabbasi
authors.forename: Daryoush
authors.initials: D
authors.lastname: Mohajeri
mesh_terms: D017607:Aluminum Compounds; D000818:Animals; D001842:Bone and Bones / Q000187:drug effects*; D002118:Calcium / Q000494:pharmacology*; D017610:Calcium Compounds; D003738:Dental Cements / Q000494:pharmacology*; D004338:Drug Combinations; D010087:Oxides; D051381:Rats; D017208:Rats, Wistar; D012387:Root Canal Filling Materials / Q000494:pharmacology*; D017640:Silicates
chemical_list: D017607:Aluminum Compounds; D017610:Calcium Compounds; D003738:Dental Cements; D004338:Drug Combinations; D010087:Oxides; D012387:Root Canal Filling Materials; D017640:Silicates; C086631:mineral trioxide aggregate; D002118:Calcium