title: Persistence of functional antibodies to group B streptococcal capsular polysaccharides following immunization with glycoconjugate vaccines.
abstract: The duration of functional activity of group B streptococcal (GBS) glycoconjugate vaccine-induced capsular polysaccharide-specific (CPS) IgG was evaluated among healthy adult responders. Opsonophagocytic activity declined significantly from a 4-week post-immunization peak, but substantial functional activity, exceeding 1 log(10) reduction in GBS cfu/mL, was retained at 18 months to 2 years post-immunization for each GBS type assessed. The persistence of functional antibody activity when GBS CPS-specific IgG concentrations decline, although remaining significantly higher than pre-immunization levels, suggests that long-term protection may be expected from candidate GBS glycoconjugates administered to this population.
authors.affiliation: Department of Pediatrics, Baylor College of Medicine, Houston, TX, USA. morvene@bcm.edu
authors.forename: Morven S
authors.initials: MS
authors.lastname: Edwards
authors.forename: Heidi J
authors.initials: HJ
authors.lastname: Lane
authors.forename: Sharon L
authors.initials: SL
authors.lastname: Hillier
authors.forename: Marcia A
authors.initials: MA
authors.lastname: Rench
authors.forename: Carol J
authors.initials: CJ
authors.lastname: Baker
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood*; D001770:Blood Bactericidal Activity; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D009895:Opsonin Proteins / Q000097:blood; D010587:Phagocytosis; D011135:Polysaccharides, Bacterial / Q000008:administration & dosage / Q000276:immunology*; D022541:Streptococcal Vaccines / Q000008:administration & dosage / Q000276:immunology*; D013292:Streptococcus agalactiae / Q000276:immunology*; D013997:Time Factors; D018074:Vaccines, Conjugate / Q000008:administration & dosage / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D009895:Opsonin Proteins; D011135:Polysaccharides, Bacterial; D022541:Streptococcal Vaccines; D018074:Vaccines, Conjugate