title: From disordered eating to addiction: the "food drug" in bulimia nervosa.
abstract: The high prevalence of substance abuse in individuals with bulimia nervosa (BN) and the pervasive symptom substitution in many types of drug addiction suggest that a number of substances--including food--can impair an individual's self-control, even in the presence of negative consequences. Nonetheless, the neurobiological similarities between BN and drug addiction are not clearly established. This review explores how the specific eating patterns seen in BN (binge eating and purging, with intermittent dietary restriction) are particularly addictive and differentiate BN from other eating disorders and obesity. A number of peripheral and central biological aberrations seen in BN may result in altered reward sensitivity in these individuals, particularly through effects on the dopaminergic system. Neurobiological findings support the notion that BN is an addictive disorder, which has treatment implications for therapy and pharmacological manipulations.
authors.affiliation: Department of Molecular Physiology and Pharmacology, Tufts University School of Medicine, Boston, MA 02111, USA.
authors.forename: Erin N
authors.initials: EN
authors.lastname: Umberg
authors.forename: Richard I
authors.initials: RI
authors.lastname: Shader
authors.forename: L K George
authors.initials: LK
authors.lastname: Hsu
authors.forename: David J
authors.initials: DJ
authors.lastname: Greenblatt
mesh_terms: D016739:Behavior, Addictive; D052018:Bulimia Nervosa / Q000209:etiology / Q000378:metabolism / Q000523:psychology* / Q000628:therapy; D004298:Dopamine / Q000502:physiology; D001068:Feeding and Eating Disorders / Q000378:metabolism / Q000503:physiopathology / Q000523:psychology* / Q000628:therapy; D006801:Humans; D009474:Neurons / Q000378:metabolism; D012054:Reinforcement, Psychology
chemical_list: D004298:Dopamine