title: 2,4,6-Trichlorophenylhydrazine Schiff bases as DPPH radical and super oxide anion scavengers.
abstract: Syntheses of thirty 2,4,6-trichlorophenylhydrazine Schiff bases 1-30 were carried out and evaluated for their in vitro DPPH radical and super oxide anion scavenging activities. Compounds 1-30 have shown a varying degree of DPPH radical scavenging activity and their IC50 values range between 4.05-369.30 µM. The compounds 17, 28, 18, 14, 8, 15, 12, 2, 29, and 7 exhibited IC50 values ranging between 4.05±0.06-24.42±0.86 µM which are superior to standard n-propylgallate (IC50=30.12±0.27 µM). Selected compounds have shown a varying degree of superoxide anion radical scavenger activity and their IC50 values range between 91.23-406.90 µM. The compounds 28, 8, 17, 15, and 14, showed IC50 values between 91.23±1.2-105.31±2.29 µM which are superior to standard n-propylgallate (IC50=106.34±1.6 µM).
authors.affiliation: H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan. hassaan2@super.net.pk
authors.forename: Khalid Mohammed
authors.initials: KM
authors.lastname: Khan
authors.forename: Zarbad
authors.initials: Z
authors.lastname: Shah
authors.forename: Viqar Uddin
authors.initials: VU
authors.lastname: Ahmad
authors.forename: Momin
authors.initials: M
authors.lastname: Khan
authors.forename: Muhammad
authors.initials: M
authors.lastname: Taha
authors.forename: Fazal
authors.initials: F
authors.lastname: Rahim
authors.forename: Sajjad
authors.initials: S
authors.lastname: Ali
authors.forename: Nida
authors.initials: N
authors.lastname: Ambreen
authors.forename: Shahnaz
authors.initials: S
authors.lastname: Perveen
authors.forename: M Iqbal
authors.initials: MI
authors.lastname: Choudhary
authors.forename: Wolfgang
authors.initials: W
authors.lastname: Voelter
mesh_terms: D000838:Anions; D001713:Biphenyl Compounds / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000737:chemistry*; D006834:Hydrazines / Q000138:chemical synthesis / Q000737:chemistry*; D015394:Molecular Structure; D010851:Picrates / Q000737:chemistry*; D012545:Schiff Bases / Q000138:chemical synthesis / Q000737:chemistry; D013481:Superoxides / Q000737:chemistry*
chemical_list: D000838:Anions; D001713:Biphenyl Compounds; D016166:Free Radical Scavengers; D006834:Hydrazines; D010851:Picrates; D012545:Schiff Bases; D013481:Superoxides; C071044:2,4,6-trichlorophenylhydrazine; C004931:1,1-diphenyl-2-picrylhydrazyl