title: Quality of Life and Utility in Patients with Metastatic Soft Tissue and Bone Sarcoma: The Sarcoma Treatment and Burden of Illness in North America and Europe (SABINE) Study.
abstract: The aim of the study was to assess health-related quality of life (HRQoL) among metastatic soft tissue (mSTS) or bone sarcoma (mBS) patients who had attained a favourable response to chemotherapy. We employed the EORTC QLQ-C30, the 3-item Cancer-Related Symptoms Questionnaire, and the EQ-5D instrument. HRQoL was evaluated overall and by health state in 120 mSTS/mBS patients enrolled in the SABINE study across nine countries in Europe and North America. Utility was estimated from responses to the EQ-5D instrument using UK population-based weights. The mean EQ-5D utility score was 0.69 for the pooled patient sample with little variation across health states. However, patients with progressive disease reported a clinically significant lower utility (0.56). Among disease symptoms, pain and respiratory symptoms are common. This study showed that mSTS/mBS is associated with reduced HRQoL and utility among patients with metastatic disease.
authors.affiliation: Department of Hematology, Oncology and Palliative Care, Sarcoma Center Berlin-Brandenburg, HELIOS Klinikum Bad Saarow, 15526 Bad Saarow, Germany.
authors.forename: Peter
authors.initials: P
authors.lastname: Reichardt
authors.forename: Michael
authors.initials: M
authors.lastname: Leahy
authors.forename: Xavier
authors.initials: X
authors.lastname: Garcia Del Muro
authors.forename: Stefano
authors.initials: S
authors.lastname: Ferrari
authors.forename: Javier
authors.initials: J
authors.lastname: Martin
authors.forename: Hans
authors.initials: H
authors.lastname: Gelderblom
authors.forename: Jingshu
authors.initials: J
authors.lastname: Wang
authors.forename: Arun
authors.initials: A
authors.lastname: Krishna
authors.forename: Jennifer
authors.initials: J
authors.lastname: Eriksson
authors.forename: Arthur
authors.initials: A
authors.lastname: Staddon
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Blay