title: Demethoxycurcumin inhibits cell proliferation, migration and invasion             in prostate cancer cells.
abstract: Curcumin (CUR) is a natural agent that has been demonstrated to effectively             inhibit prostate cancer growth. However, natural CUR is relatively unstable and             can be easily degraded in vivo. Therefore, it is essential to develop other stable             curcuminoids. Demethoxycurcumin (DMC) is a candidate that has been verified in             several tumor types and has potential for the treatment of prostate cancer. In             the present study, we investigated the effects of DMC on proliferation, apoptosis             and migration of PC-3 cells. MTT assay results indicated that DMC inhibited PC-3             cell viability in a dose- and time-dependent manner, and DMC induced G2/M phase             arrest. Furthermore, PC-3 cells in DMC-treated groups had a higher apoptotic rate             compared with DMSO-treated control. This effect may be due to the activation of             the caspase-3 pathway. In DMC-treated groups, migrating and invasive cells were             dramatically reduced (P<0.05). The activity of MMP-2, which is correlated with             migration and invasion was also suppressed by DMC. These results indicated that             DMC may inhibit PC-3 cell migration and invasion partially by affecting MMP-2             activity. In conclusion, DMC significantly inhibits proliferation, migration and             invasion of cultured PC-3 cells, and this study may provide evidence for future             in vivo studies and clinical use.
authors.affiliation: Department of Urology, The Fourth Hospital, Hebei Medical University, Hebei 050011, PR China.
authors.forename: Xiaochen
authors.initials: X
authors.lastname: Ni
authors.forename: Aili
authors.initials: A
authors.lastname: Zhang
authors.forename: Zhihong
authors.initials: Z
authors.lastname: Zhao
authors.forename: Yongqing
authors.initials: Y
authors.lastname: Shen
authors.forename: Shijie
authors.initials: S
authors.lastname: Wang
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis; D053148:Caspase 3 / Q000378:metabolism; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects*; D049109:Cell Proliferation / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D003474:Curcumin / Q000031:analogs & derivatives* / Q000494:pharmacology; D036381:Diarylheptanoids; D004789:Enzyme Activation; D006801:Humans; D059566:M Phase Cell Cycle Checkpoints / Q000187:drug effects; D008297:Male; D020778:Matrix Metalloproteinase 2 / Q000378:metabolism; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D011471:Prostatic Neoplasms
chemical_list: D000970:Antineoplastic Agents; D036381:Diarylheptanoids; D018809:Proliferating Cell Nuclear Antigen; C505407:CASP3 protein, human; D053148:Caspase 3; C522361:MMP2 protein, human; D020778:Matrix Metalloproteinase 2; D003474:Curcumin; C050229:demethoxycurcumin