title: Amphiphilic α-helix mimetics based on a benzoylurea scaffold.
abstract: The design and synthesis of amphiphilic benzoylurea α-helix mimetics is described. These conformationally constrained molecules allow for the correct angular and spatial projection of hydrophobic and hydrophilic groups and thus the reproduction of side-chains on both faces of an α-helix.
authors.affiliation: Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK.
authors.forename: Sam
authors.initials: S
authors.lastname: Thompson
authors.forename: Andrew D
authors.initials: AD
authors.lastname: Hamilton
mesh_terms: D057927:Hydrophobic and Hydrophilic Interactions; D008958:Models, Molecular; D057786:Peptidomimetics / Q000737:chemistry*; D017433:Protein Structure, Secondary; D014508:Urea / Q000737:chemistry*
chemical_list: D057786:Peptidomimetics; D014508:Urea