title: Aspirin-exacerbated respiratory disease: burden of disease.
abstract: Aspirin-exacerbated respiratory disease (AERD) is characterized by adult onset of asthma, chronic rhinosinusitis (CRS), nasal polyposis, and aspirin sensitivity. In this syndrome, each disease component has deleterious effects on the patient's health and quality of life. Latest figures from the Centers for Disease Control indicate 8.2% of the U.S. population has asthma and among adult asthmatic patients, up to 9% have AERD. Approximately 13% of the population suffers from CRS and 15% of patients with CRS with nasal polyposis have AERD. A review of the impact that each component of AERD has on patients will delineate the considerable burden of AERD, especially when considering the cumulative effects of the tetrad.
authors.affiliation: Scripps Clinic, La Jolla, California, USA. Chang.Jinny@scrippshealth.org
authors.forename: Jinny E
authors.initials: JE
authors.lastname: Chang
authors.forename: Andrew
authors.initials: A
authors.lastname: White
authors.forename: Ronald A
authors.initials: RA
authors.lastname: Simon
authors.forename: Donald D
authors.initials: DD
authors.lastname: Stevenson
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects*; D055963:Asthma, Aspirin-Induced / Q000145:classification / Q000191:economics* / Q000503:physiopathology; D002908:Chronic Disease; D017281:Cost of Illness; D016861:Cyclooxygenase Inhibitors / Q000191:economics / Q000627:therapeutic use; D006801:Humans; D009298:Nasal Polyps / Q000209:etiology / Q000503:physiopathology; D000857:Olfaction Disorders / Q000191:economics / Q000209:etiology / Q000503:physiopathology; D011788:Quality of Life; D012140:Respiratory Tract Diseases / Q000191:economics* / Q000209:etiology* / Q000503:physiopathology; D012220:Rhinitis / Q000191:economics / Q000209:etiology / Q000503:physiopathology; D012852:Sinusitis / Q000191:economics / Q000209:etiology / Q000503:physiopathology; D014481:United States / Q000453:epidemiology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D001241:Aspirin