title: Low molecular mass dermatan sulfate modulates endothelial cells proliferation and migration.
abstract: Low molecular mass dermatan sulfate, obtained by depolymerization, induced the entrance in S phase of mitosis, enhanced the activity of matrix metalloproteinase-2, and could modulate cell migration of endothelial cells, through mechanisms independent of TNF-α autocrine regulation. LMMDS located at the injured sites could influence early stages of angiogenesis.
authors.affiliation: Biological Science Department, School of Pharmacy and Biochemistry, University of Buenos Aires, Junín 956, Ciudad Autónoma de Buenos Aires C1113AAD, Argentina.
authors.forename: Rita Yanina
authors.initials: RY
authors.lastname: Rasente
authors.forename: Paula
authors.initials: P
authors.lastname: Egitto
authors.forename: Graciela Cristina
authors.initials: GC
authors.lastname: Calabrese
mesh_terms: D000818:Animals; D002465:Cell Movement / Q000187:drug effects; D049109:Cell Proliferation / Q000187:drug effects; D002478:Cells, Cultured; D003871:Dermatan Sulfate / Q000494:pharmacology*; D042783:Endothelial Cells / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D020778:Matrix Metalloproteinase 2 / Q000235:genetics / Q000378:metabolism*; D051379:Mice; D008970:Molecular Weight; D009206:Myocardium / Q000166:cytology; D016196:S Phase / Q000187:drug effects; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis / Q000378:metabolism; D015854:Up-Regulation
chemical_list: D014409:Tumor Necrosis Factor-alpha; D003871:Dermatan Sulfate; D020778:Matrix Metalloproteinase 2