title: The neuroprotective and neurogenic effects of neuropeptide Y administration in an animal model of hippocampal neurodegeneration and temporal lobe epilepsy induced by trimethyltin.
abstract: The effects of intracerebroventricular administration of neuropeptide Y (NPY), which is believed to play an important role in neuroprotection against excitotoxicity and in the modulation of adult neurogenesis, were evaluated in an animal model of hippocampal neurodegeneration and temporal lobe epilepsy represented by trimethyltin (TMT) intoxication. A single TMT injection (8 mg/kg) causes, in the rat brain, massive neuronal death, selectively involving pyramidal neurons, accompanied by glial activation and enhanced hippocampal neurogenesis. Our data indicate that intracerebroventricular administration of exogenous NPY (at the dose of 2 μg/2 μL, 4 days after TMT-administration), in adult rats, exerts a protective role in regard to TMT-induced hippocampal damage and a proliferative effect on the hippocampal neurogenic niche through the up-regulation of Bcl-2, Bcl2l1, Bdnf, Sox-2, NeuroD1, Noggin and Doublecortin genes, contributing to delineate more clearly the role of NPY in in vivo neurodegenerative processes.
authors.affiliation: Institute of Anatomy and Cell Biology, Università Cattolica del Sacro Cuore, Rome, Italy.
authors.forename: Valentina
authors.initials: V
authors.lastname: Corvino
authors.forename: Elisa
authors.initials: E
authors.lastname: Marchese
authors.forename: Stefano
authors.initials: S
authors.lastname: Giannetti
authors.forename: Wanda
authors.initials: W
authors.lastname: Lattanzi
authors.forename: Davide
authors.initials: D
authors.lastname: Bonvissuto
authors.forename: Filippo
authors.initials: F
authors.lastname: Biamonte
authors.forename: Adriana Maria
authors.initials: AM
authors.lastname: Mongiovì
authors.forename: Fabrizio
authors.initials: F
authors.lastname: Michetti
authors.forename: Maria Concetta
authors.initials: MC
authors.lastname: Geloso
mesh_terms: D000818:Animals; D000963:Antimetabolites; D051017:Apoptosis Regulatory Proteins / Q000096:biosynthesis; D019208:Brain-Derived Neurotrophic Factor / Q000096:biosynthesis; D001973:Bromodeoxyuridine; D000089662:Doublecortin Protein; D004833:Epilepsy, Temporal Lobe / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology*; D005260:Female; D015870:Gene Expression / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects* / Q000473:pathology; D007150:Immunohistochemistry; D007276:Injections, Intraventricular; D009410:Nerve Degeneration / Q000209:etiology / Q000517:prevention & control*; D009419:Nerve Tissue Proteins / Q000096:biosynthesis / Q000235:genetics; D055495:Neurogenesis / Q000187:drug effects* / Q000235:genetics; D009478:Neuropeptide Y / Q000008:administration & dosage / Q000494:pharmacology*; D018696:Neuroprotective Agents; D012313:RNA / Q000096:biosynthesis / Q000302:isolation & purification; D051381:Rats; D017208:Rats, Wistar; D060888:Real-Time Polymerase Chain Reaction; D017476:Receptors, Neuropeptide Y / Q000187:drug effects; D014298:Trimethyltin Compounds
chemical_list: D000963:Antimetabolites; D051017:Apoptosis Regulatory Proteins; D019208:Brain-Derived Neurotrophic Factor; C000714848:Dcx protein, rat; D000089662:Doublecortin Protein; D009419:Nerve Tissue Proteins; D009478:Neuropeptide Y; D018696:Neuroprotective Agents; D017476:Receptors, Neuropeptide Y; D014298:Trimethyltin Compounds; C046488:trimethyltin; D012313:RNA; D001973:Bromodeoxyuridine