title: Osteoblastic osteosarcoma in a rabbit.
abstract: An osteosarcoma developed in the tarsal joint region involving the distal tibia of a domestic rabbit (Oryctolagus cuniculus). Micrometastases were present in the lungs. Histologically the tumor was composed of ovoid to short-spindle cells with abundant giant cells, producing  irregular islands of osteoids. The tumor cells were immunopositive with antiosteocalcin monoclonal antibody, consistent with their derivation from osteoblasts. According to review of 10 published cases, productive osteoblasic osteosarcoma is the most common bone tumor in rabbits, with half  of all cases developing in the skull or facial bones.
authors.affiliation: Laboratory of Veterinary Pathology, College of Bioresource Sciences, Nihon University, Fujisawa, Kanagawa, Japan.
authors.forename: Megumi
authors.initials: M
authors.lastname: Ishikawa
authors.forename: Hirotaka
authors.initials: H
authors.lastname: Kondo
authors.forename: Mamoru
authors.initials: M
authors.lastname: Onuma
authors.forename: Hisashi
authors.initials: H
authors.lastname: Shibuya
authors.forename: Tsuneo
authors.initials: T
authors.lastname: Sato
mesh_terms: D000820:Animal Diseases / Q000378:metabolism / Q000473:pathology*; D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis; D001706:Biopsy / Q000662:veterinary; D001859:Bone Neoplasms / Q000662:veterinary*; D005260:Female; D007150:Immunohistochemistry / Q000662:veterinary; D008175:Lung Neoplasms / Q000662:veterinary*; D061206:Neoplasm Micrometastasis; D010006:Osteoblasts / Q000737:chemistry / Q000473:pathology*; D015675:Osteocalcin / Q000032:analysis; D012516:Osteosarcoma / Q000662:veterinary*; D057805:Pets; D011817:Rabbits; D011859:Radiography; D013977:Tibia / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; D015675:Osteocalcin