title: The epidemiology of Alzheimer's disease: laying the foundation for drug design, conduct, and analysis of clinical trials.
abstract: Epidemiological studies increasingly inform Alzheimer's disease (AD) public health impact, prevention strategies, drug targets, therapeutic interventions, and clinical trial design. For this reason, the Alzheimer's Association Research Roundtable convened an international group of AD experts with experience in conducting both observational and clinical trials for a meeting on October 19 and 20, 2010, in Washington, DC, to discuss the role of epidemiologic studies in AD research and therapeutic advances. Topics included wellness markers and risk factors, with a focus on special populations such as those at elevated risk, super agers, and underserved populations. Discussions also highlighted lessons learned from observational studies of aging, cardiovascular disease, and other disease areas, as well as how new technologies have enabled the gathering of data relevant to drug development and clinical trial conduct.
authors.affiliation: Departments of Psychiatry, Neurology and Epidemiology, University of California, San Francisco, USA.
authors.forename: Kristine
authors.initials: K
authors.lastname: Yaffe
authors.forename: Michael
authors.initials: M
authors.lastname: Tocco
authors.forename: Ronald C
authors.initials: RC
authors.lastname: Petersen
authors.forename: Catherine
authors.initials: C
authors.lastname: Sigler
authors.forename: Leah C
authors.initials: LC
authors.lastname: Burns
authors.forename: Christel
authors.initials: C
authors.lastname: Cornelius
authors.forename: Ara S
authors.initials: AS
authors.lastname: Khachaturian
authors.forename: Michael C
authors.initials: MC
authors.lastname: Irizarry
authors.forename: Maria C
authors.initials: MC
authors.lastname: Carrillo
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000453:epidemiology*; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D015195:Drug Design; D016021:Epidemiologic Studies; D006801:Humans; D007391:International Cooperation
chemical_list: D014150:Antipsychotic Agents