title: [Biologic modulation of ionizing radiation by Toll-like receptors agonists: towards an increase in the therapeutic index of radiotherapy?].
abstract: Toll-like receptors are ubiquitous and very well conserved throughout evolution, with important functions mediating innate and adaptative immunological mechanisms. The importance of these receptors and their agonists has been recently pointed out in immunology and cancerology, although the accurate underlying mechanisms are still under investigation. The association of agonists of these receptors with ionizing radiation has been studied in preclinical experiments with promising results. Part of these compounds is flagellin, which seems to be able to modulate the radiosensitivity of both tumors and healthy tissues.
authors.affiliation: CRLC Val-d'Aurelle, service d'oncologie radiothérapie, 34298 Montpellier, France. riou@hotmail.com
authors.forename: Olivier
authors.initials: O
authors.lastname: Riou
authors.forename: David
authors.initials: D
authors.lastname: Azria
authors.forename: Christel
authors.initials: C
authors.lastname: Larbouret
authors.forename: Bruno
authors.initials: B
authors.lastname: Robert
mesh_terms: D003131:Combined Modality Therapy / Q000379:methods; D018899:CpG Islands / Q000276:immunology / Q000528:radiation effects; D005408:Flagellin / Q000494:pharmacology*; D006801:Humans; D007107:Immune System / Q000528:radiation effects*; D009369:Neoplasms / Q000276:immunology / Q000532:radiotherapy*; D058958:Organs at Risk / Q000528:radiation effects; D011836:Radiation Tolerance / Q000187:drug effects* / Q000502:physiology; D011839:Radiation, Ionizing; D011837:Radiation-Protective Agents / Q000627:therapeutic use; D011879:Radiotherapy Dosage; D051193:Toll-Like Receptors / Q000819:agonists* / Q000276:immunology / Q000502:physiology*
chemical_list: D011837:Radiation-Protective Agents; D051193:Toll-Like Receptors; D005408:Flagellin