title: Copper(I)-mediated cascade reactions: an efficient approach to the synthesis of functionalized benzofuro[3,2-d]pyrimidines.
abstract: A novel cascade reaction was developed for the synthesis of diverse members of a series of benzofuro[3,2-d]pyrimidine derivatives. The process utilizes readily prepared 3-chlorochromenones and various commercially available amidines and their analogues as starting materials. This tandem reaction is promoted by using a simple copper(I) reagent and involves a chemoselective Michael addition-heterocyclization-intramolecular cyclization sequence.
authors.affiliation: State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai 201203, China.
authors.forename: Bo
authors.initials: B
authors.lastname: Chao
authors.forename: Shijun
authors.initials: S
authors.lastname: Lin
authors.forename: Qingdong
authors.initials: Q
authors.lastname: Ma
authors.forename: Dong
authors.initials: D
authors.lastname: Lu
authors.forename: Youhong
authors.initials: Y
authors.lastname: Hu
mesh_terms: D001572:Benzofurans / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D003300:Copper / Q000737:chemistry*; D003500:Cyclization; D015394:Molecular Structure; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001572:Benzofurans; D011743:Pyrimidines; D003300:Copper