title: [Estrogen actions on osteocytes].
abstract: Estrogen is well-known to play essential roles for maintenance of bone mass. Although its osteoprotective actions are mediated mainly through suppressing bone resorption, several reports has suggested that ERα/estrogen signal in osteocytes has some osteoprotective effects. For example, ERαis reported to be involved in adaptive response to loading which is thought to be sensed by osteocytes. Estrogen is also thought to be a viable factor for osteocytes. In addition, our group recently found that osteocytic ERαexhibited decreased bone mass, suggesting that osteocytic ERαexerts osteoprotective function. Also, functions of osteocyte itself have been characterized recently. These findings may lead to an understanding of estrogen actions on osteocytes and to a comprehensive understanding of estrogen actions on bone.
authors.affiliation: University of Tokyo, Japan.
authors.forename: Shino
authors.initials: S
authors.lastname: Kondoh
authors.forename: Yuuki
authors.initials: Y
authors.lastname: Imai
mesh_terms: D000818:Animals; D001862:Bone Resorption / Q000235:genetics / Q000378:metabolism; D001842:Bone and Bones / Q000378:metabolism*; D047628:Estrogen Receptor alpha / Q000235:genetics* / Q000502:physiology*; D004967:Estrogens / Q000502:physiology*; D006801:Humans; D010011:Osteocytes / Q000502:physiology*; D013314:Stress, Mechanical
chemical_list: D047628:Estrogen Receptor alpha; D004967:Estrogens