title: Serum intact-parathyroid hormone level following total knee arthroplasty.
abstract: OBJECTIVE
  To evaluate short-term parathyroid hormone (PTH) secretion following total knee arthroplasty (TKA).
  
  
  METHODS
  119 Caucasian postmenopausal women aged 49 to 81 (mean, 69.8) years who underwent TKA for end-stage knee osteoarthritis were included. Serum levels of intact-PTH, calcium, phosphorus, and creatinine were evaluated pre- and post-operatively (on days -1 and 7). Creatinine clearance was also calculated.
  
  
  RESULTS
  In 67 of the patients, serum intact-PTH levels decreased after TKA; this sample proportion was not significant (p=0.82). In 16 of the patients, such levels elevated abnormally (above normal range). In the remaining 36 patients, such levels elevated within the normal range. Therefore, the mean serum intact- PTH level of all patients increased slightly after TKA (45.4 vs. 45.3, p=0.162). The serum intact-PTH level did not correlate to body weight (r=-0.045, p=0.624), patient age (r=-0.061, p=0.508), serum creatinine level (r=0.084, p=0.366), and clearance of creatinine (r=-0.037, p=0.692).
  
  
  CONCLUSIONS
  In most postmenopausal women, the serum intact-PTH level decreased moderately following TKA, but in some, the level was abnormally elevated. This may interfere the prosthesis incorporation process.
authors.affiliation: 3rd Orthopaedic Department, Aristotle University of Thessaloniki-Medical School, Papageorgiou General Hospital, Thessaloniki, Greece. kyrpap2005@yahoo.com
authors.forename: Kyriakos A
authors.initials: KA
authors.lastname: Papavasiliou
authors.forename: Aggeliki
authors.initials: A
authors.lastname: Nikopoulou
authors.forename: Eustathios I
authors.initials: EI
authors.lastname: Kenanidis
authors.forename: Michael E
authors.initials: ME
authors.lastname: Potoupnis
authors.forename: Margaritis J
authors.initials: MJ
authors.lastname: Kyrkos
authors.forename: Fares E
authors.initials: FE
authors.lastname: Sayegh
authors.forename: George A
authors.initials: GA
authors.lastname: Kapetanos
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D019645:Arthroplasty, Replacement, Knee; D005260:Female; D006801:Humans; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood*; D011446:Prospective Studies
chemical_list: D010281:Parathyroid Hormone