title: Acute stroke management in patients taking dabigatran.
abstract: Dabigatran etexilate is emerging as an alternative for vitamin K antagonists, but evidence-based guidelines for management of intracerebral hemorrhage and acute ischemic stroke in patients taking this drug are nonexistent. This review summarizes current knowledge on key pharmacological features and the assessment of dabigatran activity. Pragmatic approaches are provided for individualized decision taking with regard to hemostatic therapy and reperfusion strategies in acute stroke patients.
authors.affiliation: Department of Neurology, Universitair Ziekenhuis Brussel, Center for Neurosciences (C4N), Vrije Universiteit Brussel (VUB), Brussels, Belgium. raf.brouns@uzbrussel.be
authors.forename: Raf
authors.initials: R
authors.lastname: Brouns
authors.forename: Robbert-Jan
authors.initials: RJ
authors.lastname: Van Hooff
authors.forename: Ann
authors.initials: A
authors.lastname: De Smedt
authors.forename: Maarten
authors.initials: M
authors.lastname: Moens
authors.forename: Sylvie
authors.initials: S
authors.lastname: De Raedt
authors.forename: Maarten
authors.initials: M
authors.lastname: Uyttenboogaart
authors.forename: Gert-Jan
authors.initials: GJ
authors.lastname: Luijckx
authors.forename: Kristin
authors.initials: K
authors.lastname: Jochmans
authors.forename: Jacques
authors.initials: J
authors.lastname: De Keyser
mesh_terms: D000925:Anticoagulants / Q000037:antagonists & inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000037:antagonists & inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D001778:Blood Coagulation Disorders / Q000139:chemically induced / Q000188:drug therapy; D019090:Case Management; D002543:Cerebral Hemorrhage / Q000097:blood / Q000188:drug therapy; D002544:Cerebral Infarction / Q000188:drug therapy; D000069604:Dabigatran; D017408:Guidelines as Topic; D006487:Hemostasis / Q000187:drug effects; D006490:Hemostatics / Q000627:therapeutic use; D006801:Humans; D056687:Off-Label Use; D011725:Pyridines / Q000037:antagonists & inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D006435:Renal Dialysis; D015424:Reperfusion; D020521:Stroke / Q000188:drug therapy*; D014812:Vitamin K / Q000037:antagonists & inhibitors
chemical_list: D000925:Anticoagulants; D001562:Benzimidazoles; D006490:Hemostatics; D011725:Pyridines; D014812:Vitamin K; D000069604:Dabigatran