title: Rationale for further medical and health research on high-potency sweeteners.
abstract: High-potency or artificial sweeteners have historically been considered inert compounds without physiological consequences other than taste sensations. However, recent data suggest that some of these sweeteners have biological effects that may impact human health. Furthermore, there are significant gaps in our current knowledge of the pharmacokinetics of these sweeteners, their potential for "sweetener-drug interactions" and their impact on appetite and body weight regulation. Nine research needs are described that address some of the major unknown issues associated with ingestion of high-potency sweeteners.
authors.affiliation: Schiffman Consulting, 18 Heath Place, Durham, NC 27705-5713, USA. sschiffman@nc.rr.com
authors.forename: Susan S
authors.initials: SS
authors.lastname: Schiffman
mesh_terms: D000042:Absorption; D000818:Animals; D001066:Appetite / Q000187:drug effects; D035843:Biomedical Research / Q000639:trends*; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D004347:Drug Interactions; D059022:Food Safety; D041981:Gastrointestinal Tract / Q000187:drug effects / Q000382:microbiology; D006358:Hot Temperature; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D013549:Sweetening Agents / Q000009:adverse effects / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics
chemical_list: D013549:Sweetening Agents