title: Associations between XPD Asp312Asn polymorphism and risk of head and neck cancer: a meta-analysis based on 7,122 subjects.
abstract: BACKGROUND
  To investigate the association between XPD Asp312Asn polymorphism and head and neck cancer risk through this meta-analysis.
  
  
  METHODS
  We performed a meta-analysis of 9 published case-control studies including 2,670 patients with head and neck cancer and 4,452 controls. An odds ratio (OR) with a 95% confidence interval (CI) was applied to assess the association between XPD Asp312Asn polymorphism and head and neck cancer risk.
  
  
  RESULTS
  Overall, no significant association between XPD Asp312Asn polymorphism and head and neck cancer risk was found in this meta-analysis (Asn/Asn vs. Asp/Asp: OR = 0.95, 95%CI = 0.80-1.13, P = 0.550, P(heterogeneity) = 0.126; Asp/Asn vs. Asp/Asp: OR = 1.11, 95%CI = 0.99-1.24, P = 0.065, P(heterogeneity) = 0.663; Asn/Asn+Asp/Asn vs. Asp/Asp: OR = 1.07, 95%CI = 0.97-1.19, P = 0.189, P(heterogeneity) = 0.627; Asn/Asn vs. Asp/Asp+Asp/Asn: OR = 0.87, 95%CI = 0.68-1.10, P = 0.243, P(heterogeneity) = 0.089). In the subgroup analysis by HWE, ethnicity, and study design, there was still no significant association detected in all genetic models.
  
  
  CONCLUSIONS
  This meta-analysis demonstrates that XPD Asp312Asn polymorphism may not be a risk factor for developing head and neck cancer.
authors.affiliation: Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan, People's Republic of China.
authors.forename: Yuan Yuan
authors.initials: YY
authors.lastname: Hu
authors.forename: Hua
authors.initials: H
authors.lastname: Yuan
authors.forename: Guang Bing
authors.initials: GB
authors.lastname: Jiang
authors.forename: Ning
authors.initials: N
authors.lastname: Chen
authors.forename: Li
authors.initials: L
authors.lastname: Wen
authors.forename: Wei Dong
authors.initials: WD
authors.lastname: Leng
authors.forename: Xian Tao
authors.initials: XT
authors.lastname: Zeng
authors.forename: Yu Ming
authors.initials: YM
authors.lastname: Niu
mesh_terms: D019943:Amino Acid Substitution; D044466:Asian People; D016022:Case-Control Studies; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D006258:Head and Neck Neoplasms / Q000208:ethnology / Q000235:genetics*; D006801:Humans; D016017:Odds Ratio; D020641:Polymorphism, Single Nucleotide; D012307:Risk Factors; D044465:White People; D051759:Xeroderma Pigmentosum Group D Protein / Q000235:genetics*
chemical_list: D051759:Xeroderma Pigmentosum Group D Protein; C497292:ERCC2 protein, human