title: Comparison of MR enteroclysis with video capsule endoscopy in the investigation of small-intestinal disease.
abstract: OBJECTIVE
  To evaluate the diagnostic accuracy of MR enteroclysis and to compare it to video capsule endoscopy (VCE) in the analysis of suspected small-bowel disease.
  
  
  METHODS
  We performed a retrospective analysis of 77 patients who underwent both MR enteroclysis and VCE and compared the findings of these studies with the findings of enteroscopy, surgery, or with the results of clinical follow-up lasting ≥2 years.
  
  
  RESULTS
  Findings included malignant neoplasms (n = 13), benign neoplasms (n = 10), refractory celiac disease (n = 4), Crohn's disease (n = 2) and miscellaneous conditions (n = 10). Specificity of MR enteroclysis was higher than that of VCE (0.97 vs. 0.84, P = 0.047), whereas sensitivity was similar (0.79 vs. 0.74, P = 0.591). In 2/32 (6.3%) patients with both negative VCE and negative MR enteroclysis a positive diagnosis was established, compared to 5/11 (45.5%) patients in whom VCE was positive and MR enteroclysis was negative (likelihood ratio 8.1; P = 0.004), 9/11 (81.8%) patients in whom MR enteroclysis was positive and VCE was negative (likelihood ratio 23.5; P < 0.0001), and all 23 patients in whom both VCE and MR enteroclysis showed abnormalities (likelihood ratio 60.8; P < 0.0001).
  
  
  CONCLUSIONS
  VCE and MR enteroclysis are complementary modalities. In our study-population, MR enteroclysis was more specific than VCE, while both produced the same sensitivity.
authors.affiliation: Department of Gastroenterology and Hepatology, VU University Medical Centre, De Boelelaan 1118, 1081 HV, Amsterdam, The Netherlands. sjb.vanweyenberg@vumc.nl
authors.forename: Stijn J B
authors.initials: SJ
authors.lastname: Van Weyenberg
authors.forename: Koen
authors.initials: K
authors.lastname: Bouman
authors.forename: Maarten A J M
authors.initials: MA
authors.lastname: Jacobs
authors.forename: Brendan P
authors.initials: BP
authors.lastname: Halloran
authors.forename: Donald L
authors.initials: DL
authors.lastname: Van der Peet
authors.forename: Chris J J
authors.initials: CJ
authors.lastname: Mulder
authors.forename: Cornelis
authors.initials: C
authors.lastname: Van Kuijk
authors.forename: Jan Hein T M
authors.initials: JH
authors.lastname: Van Waesberghe
mesh_terms: D053704:Capsule Endoscopy; D016009:Chi-Square Distribution; D003287:Contrast Media; D005260:Female; D006801:Humans; D007410:Intestinal Diseases / Q000175:diagnosis* / Q000473:pathology; D007421:Intestine, Small; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media