title: Urinary endothelin-1-like immunoreactivity excretion in Wilms' tumor survivors.
abstract: BACKGROUND
  We evaluated urinary endothelin (ET)-1-like Immunoreactivity (uET-1 L) excretion in Wilms tumor (WT) survivors and investigated its relationships with glomerular filtration rate (GFR) and effective renal plasma flow (ERPF). Glomerular hemodynamics were also assessed by Gomez formulae.
  
  
  METHODS
  Seventeen WT survivors underwent renal sequential scintigraphy for residual kidney function determination including ERPF and GFR. Forty-five healthy individuals were selected as the control group. uET-1 L was measured by radioimmunoassay from the 24-h urine collection.
  
  
  RESULTS
  In WT survivors, uET-1 L excretion was significantly higher than in controls. Significant correlations were found between uET-1 L and ERPF and GFR. Cluster analysis, applied on uET-1 L, identified two different patient groups. Between them, GFR and ERPF were significantly different. No significant difference existed between the two clusters for age and sex, elapsed time from nephrectomy, treatment, or nephrectomy side. Applying Gomez formulae, significant difference was found for afferent and total renal resistance.
  
  
  CONCLUSIONS
  According to our results, uET-1 L seems to be a marker of glomerular injury in patients with renal mass loss revealing renal overload condition. The uET-1 L role in renal damage progression and hemodynamic glomerular worsening in nephrectomized patients should be proven by prospective long-term follow-up studies, even for potential ET-1 receptor antagonist therapeutic use.
authors.affiliation: Biophysics and Nuclear Medicine, Hautepierre University Hospital, Strasbourg, France.
authors.forename: Alessio
authors.initials: A
authors.lastname: Imperiale
authors.forename: Catia
authors.initials: C
authors.lastname: Olianti
authors.forename: Gabriella
authors.initials: G
authors.lastname: Bernini
authors.forename: Angela
authors.initials: A
authors.lastname: Tamburini
authors.forename: Maria Silvia
authors.initials: MS
authors.lastname: Tommasi
authors.forename: Giuseppe
authors.initials: G
authors.lastname: La Cava
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D015415:Biomarkers / Q000652:urine*; D002648:Child; D002675:Child, Preschool; D019332:Endothelin-1 / Q000652:urine*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007223:Infant; D007680:Kidney Neoplasms / Q000652:urine*; D008297:Male; D012079:Renal Circulation; D017741:Survivors; D009396:Wilms Tumor / Q000652:urine*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D019332:Endothelin-1