title: Intercellular adhesion molecule-1 K469E polymorphism: Is it associated with preeclampsia in the Korean population?
abstract: OBJECTIVE
  To examine whether the distribution of genotypic and allelic frequencies of ICAM-1 K469 of Korean women with preeclampsia are different from that of a control group.
  
  
  METHODS
  In this case-control study the ICAM-1 K469E polymorphism was genotyped in 42 women with preeclampsia and 138 normotensive controls who had delivered at least two normal, term infants. A direct sequencing reaction method was used to detect a single nucleotide polymorphism.
  
  
  RESULTS
  The distribution of genotype frequencies and the frequency of the K469 allele of the preeclampsia group were not significantly different from those of the controls. A similar trend was observed between the severe preeclampsia patients and the controls.
  
  
  CONCLUSIONS
  The frequencies of the KK genotype and the K allele were higher in the preeclampsia group than those in the control group. However, there was no statistically significant difference.
authors.affiliation: Department of Obstetrics and Gynecology, Konkuk University School of Medicine, Graduate School of Medicine, Yonsei University, and Yonsei University Health System, Seoul, Republic of Korea.
authors.forename: Han-Sung
authors.initials: HS
authors.lastname: Kwon
authors.forename: In-Sook
authors.initials: IS
authors.lastname: Sohn
authors.forename: Han-Sung
authors.initials: HS
authors.lastname: Hwang
authors.forename: Yong-Won
authors.initials: YW
authors.lastname: Park
mesh_terms: D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics; D016022:Case-Control Studies; D017931:DNA Primers; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011225:Pre-Eclampsia / Q000235:genetics*; D011247:Pregnancy; D056910:Republic of Korea
chemical_list: D017931:DNA Primers; D018799:Intercellular Adhesion Molecule-1