title: [The role of heat shock proteins in immune reactions in old-aged patients with chronic generalized periodontitis].
abstract: Chronic generalized periodontitis in the old-aged patients is accompanied by high levels of the antibodies to HSP, sIgA, IgM, IgG hyperproduction; elevated concentrations of IL-8 and IL-1alpha and low content of IL-4 in saliva and blood. Local anti-inflammatory therapy of chronic periodontitis does not restore normal immunity status. Appearance of antibodies to HSP plays a role in immune reactions, which maintain chronic inflammation of periodontium.
authors.forename: Iu I
authors.initials: IuI
authors.lastname: Pinelis
authors.forename: N N
authors.initials: NN
authors.lastname: Tsybikov
authors.forename: M S
authors.initials: MS
authors.lastname: Malezhik
authors.forename: L P
authors.initials: LP
authors.lastname: Malezhik
mesh_terms: D000367:Age Factors; D000368:Aged; D000375:Aging / Q000276:immunology; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D055113:Chronic Periodontitis / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D016903:Drug Monitoring; D005260:Female; D018840:HSP70 Heat-Shock Proteins / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007109:Immunity / Q000187:drug effects; D007136:Immunoglobulins / Q000097:blood / Q000378:metabolism; D007155:Immunologic Factors / Q000378:metabolism; D007249:Inflammation / Q000188:drug therapy / Q000276:immunology*; D007378:Interleukins / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010519:Periodontium / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D012463:Saliva / Q000276:immunology; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D018840:HSP70 Heat-Shock Proteins; D007136:Immunoglobulins; D007155:Immunologic Factors; D007378:Interleukins