title: Graph spectral analysis of protein interaction network evolution.
abstract: We present an analysis of protein interaction network data via the comparison of models of network evolution to the observed data. We take a bayesian approach and perform posterior density estimation using an approximate bayesian computation with sequential Monte Carlo method. Our approach allows us to perform model selection over a selection of potential network growth models. The methodology we apply uses a distance defined in terms of graph spectra which captures the network data more naturally than previously used summary statistics such as the degree distribution. Furthermore, we include the effects of sampling into the analysis, to properly correct for the incompleteness of existing datasets, and have analysed the performance of our method under various degrees of sampling. We consider a number of models focusing not only on the biologically relevant class of duplication models, but also including models of scale-free network growth that have previously been claimed to describe such data. We find a preference for a duplication-divergence with linear preferential attachment model in the majority of the interaction datasets considered. We also illustrate how our method can be used to perform multi-model inference of network parameters to estimate properties of the full network from sampled data.
authors.affiliation: Centre of Integrative Systems Biology and Bioinformatics, Division of Molecular Biosciences, Imperial College London, London SW7 2AZ, UK. thomas.thorne@imperial.ac.uk
authors.forename: Thomas
authors.initials: T
authors.lastname: Thorne
authors.forename: Michael P H
authors.initials: MP
authors.lastname: Stumpf
mesh_terms: D000818:Animals; D001499:Bayes Theorem; D003198:Computer Simulation; D004331:Drosophila melanogaster / Q000378:metabolism; D004926:Escherichia coli / Q000378:metabolism; D019143:Evolution, Molecular; D016480:Helicobacter pylori / Q000378:metabolism; D015233:Models, Statistical; D009010:Monte Carlo Method; D060066:Protein Interaction Maps / Q000502:physiology*; D012441:Saccharomyces cerevisiae / Q000378:metabolism