title: TNF-α expression in the UCB-MSCs as stable source inhibits gastric cancers growth in nude mice.
abstract: Mesenchymal stem cells (MSCs) are potentially vehicles for therapy of malignant diseases. In our study, we investigated whether UCB-MSCs are capable to carry TNF-α to target tumor cells in vivo. The human gastric cancer cells SGC-7901 were subcutaneously injected into the abdomen near groins of 15 nude mice to establish experiment tumor models. MSC-TNF-α demonstrated a strong suppressive effect on the tumor growth compared with MSC and NaCl. Thus, MSC-TNF-α can obviously inhibit Gastric cancers growth in nude mice, indicating that UCB-MSCs may have the potential to become a prevention approach against gastric cancer.
authors.affiliation: Department of General Surgery, Qingdao Municipal Hospital, Qingdao, China.
authors.forename: Weizheng
authors.initials: W
authors.lastname: Mao
authors.forename: Xinhong
authors.initials: X
authors.lastname: Zhu
authors.forename: Dongqi
authors.initials: D
authors.lastname: Tang
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Zhao
authors.forename: Baocheng
authors.initials: B
authors.lastname: Zhao
authors.forename: Guiliang
authors.initials: G
authors.lastname: Ma
authors.forename: Xuebin
authors.initials: X
authors.lastname: Zhang
authors.forename: Gang
authors.initials: G
authors.lastname: An
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
mesh_terms: D000818:Animals; D045744:Cell Line, Tumor; D005312:Fetal Blood / Q000166:cytology; D018014:Gene Transfer Techniques; D015316:Genetic Therapy; D059630:Mesenchymal Stem Cells / Q000378:metabolism*; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D013274:Stomach Neoplasms / Q000378:metabolism*; D014162:Transfection; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics* / Q000378:metabolism
chemical_list: D014409:Tumor Necrosis Factor-alpha