title: [Risk factors for recurrent disease in borderline ovarian tumors].
abstract: OBJECTIVE
  To evaluate risk factors for development of recurrent disease in borderline ovarian tumors.
  
  
  METHODS
  Retrospective study of 10-years single institution population.
  
  
  METHODS
  Dept. of Gynecology and Obstetrics, 3rd Medical Faculty of Charles University in Prague.
  
  
  METHODS
  59 consecutive cases of borderline ovarian tumors (BOT) were analyzed for age, histopathological type, DNA ploidy, stage, presence of invasive and non-invasive peritoneal implants, type of surgical procedure, residual disease, adjuvant therapy, recurrence and long-time prognosis of the patients.
  
  
  RESULTS
  Median follow-up was 47 months (range 1-144). There were 5 (8.5%) patients with DNA aneuploid tumors in the study group; 4 of them were younger than 50 years, 4 of them were early stage serous BOT; no one recur so far. No death of disease was described in the whole study group; only 2 patients (3.4%) developed recurrent disease - both were young patients after conservative surgery for serous diploid stage I/II BOT. Conservative surgery was the only significant factor for recurrence in univariate analysis (p = 0.0159) in our setting.
  
  
  CONCLUSIONS
  DNA ploidy was not proved to be prognostic factor in borderline ovarian tumors in our study group. The only significant risk factor for development of recurrent disease was conservative surgery, with no influence on overall survival.
authors.affiliation: Gynekologicko-porodnická klinika 3. LF UK a FNKV, Praha. pavla.libalova@lf3.cuni.cz
authors.forename: P
authors.initials: P
authors.lastname: Líbalová
authors.forename: Z
authors.initials: Z
authors.lastname: Vernerová
authors.forename: L
authors.initials: L
authors.lastname: Hubicková-Heringová
authors.forename: D
authors.initials: D
authors.lastname: Pintérová
authors.forename: K
authors.initials: K
authors.lastname: Tikovský
authors.forename: M
authors.initials: M
authors.lastname: Kubecová
authors.forename: B
authors.initials: B
authors.lastname: Svoboda
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D006801:Humans; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010051:Ovarian Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D011003:Ploidies; D012307:Risk Factors; D015996:Survival Rate; D055815:Young Adult
chemical_list: D004273:DNA, Neoplasm