title: Aphanamixoid A, a potent defensive limonoid, with a new carbon skeleton from Aphanamixis polystachya.
abstract: Aphanamixoid A (1), a limonoid with a new carbon skeleton, along with its biogenetically related limonoid aphanamixoid B (2), was isolated from the leaves and twigs of Aphanamixis polystachya . Their structures with the absolute stereochemistry were determined by spectroscopic analysis, X-ray crystallography and computational methods. The significant antifeedant activity of 1 against the generalist plant-feeding insect Helicoverpa armigera (EC50 = 0.015 μmol/cm(2)) suggested it may be a potent defensive component of A. polystachya.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, P. R. China, and Graduate School of Chinese Academy of Sciences, Beijing 100039, P. R. China.
authors.forename: Jie-Yun
authors.initials: JY
authors.lastname: Cai
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Shi-Hong
authors.initials: SH
authors.lastname: Luo
authors.forename: Duo-Zhi
authors.initials: DZ
authors.lastname: Chen
authors.forename: Gui-Hua
authors.initials: GH
authors.lastname: Tang
authors.forename: Chun-Mao
authors.initials: CM
authors.lastname: Yuan
authors.forename: Ying-Tong
authors.initials: YT
authors.lastname: Di
authors.forename: Sheng-Hong
authors.initials: SH
authors.lastname: Li
authors.forename: Xiao-Jiang
authors.initials: XJ
authors.lastname: Hao
authors.forename: Hong-Ping
authors.initials: HP
authors.lastname: He
mesh_terms: D000818:Animals; D018360:Crystallography, X-Ray; D005247:Feeding Behavior / Q000187:drug effects; D007814:Larva / Q000187:drug effects; D007915:Lepidoptera / Q000187:drug effects; D036701:Limonins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D029582:Meliaceae / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D018515:Plant Leaves / Q000737:chemistry; D018547:Plant Stems / Q000737:chemistry; D018411:Spodoptera / Q000187:drug effects
chemical_list: D036701:Limonins; C587800:aphanamixoid A