title: Negative correlation between D-dimer and plasminogen activator inhibitor-1 levels is absent in obese women.
abstract: Obesity is characterized by alterations in haemostatic processes that lead to a prothrombotic state. D-dimer (D-Di) is the last product of the fibrinolysis and may reflect the haemostatic balance. As the plasminogen activator inhibitor (PAI)-1 is the main inhibitor of fibrinolysis and it is elevated in obese, we hypothesize that negative correlation exists between PAI-1 and D-Di. In addition, we evaluated if plasma levels of PAI-1 and D-Di may be correlated with clinical parameters of adiposity [waist circumference and waist-to-hip ratio (WHR)]. We measured plasma PAI-1 and D-Di concentrations using ELISA in 60 women: 21 lean women without comorbidities and 39 obese women. We found higher levels of D-Di and PAI-1 in obese groups compared to control group (P < 0.05). No differences were observed between obese and obese untreated hypertensives. PAI-1 levels, but not of D-Di, are positively correlated with BMI (control, r = 0.44) and WHR (all obese, r = 0.40). Negative correlation was found between PAI-1 and D-Di in control (r = -0.56), no association was observed in obese, signalizing to a particular attention regarding the clinical use of D-Di. Our results indicate the magnitude of central obesity as a risk factor for development of disorders related to prothrombotic states.
authors.affiliation: Núcleo de Pós-Graduação e Pesquisa, Santa Casa de Belo Horizonte, Rua Domingos Vieira 590, Belo Horizonte, Brazil.
authors.forename: Priscilla T
authors.initials: PT
authors.lastname: Ceo
authors.forename: Eveline
authors.initials: E
authors.lastname: Petruceli
authors.forename: Adriana Ap
authors.initials: AA
authors.lastname: Bosco
authors.forename: Claudia M
authors.initials: CM
authors.lastname: Andrade-Fernandes
authors.forename: Cristiane V C
authors.initials: CV
authors.lastname: Russi
authors.forename: Maria das G
authors.initials: Md
authors.lastname: Carvalho
authors.forename: Valeria C
authors.initials: VC
authors.lastname: Sandrim
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D015992:Body Mass Index; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D005342:Fibrinolysis / Q000502:physiology; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D012307:Risk Factors; D055105:Waist Circumference; D049629:Waist-Hip Ratio
chemical_list: D015415:Biomarkers; D005338:Fibrin Fibrinogen Degradation Products; D017395:Plasminogen Activator Inhibitor 1; C036309:fibrin fragment D