title: Polyostotic fibrous dysplasia in a cynomolgus Macaque (Macaca fascicularis).
abstract: A 2.3-y-old female cynomolgus macaque (Macaca fascicularis) presented with a broken right tibia and fibula. Radiographs showed multiple cyst-like defects in all long bones. We suspected that both fractures were pathologic because they occurred through these defects. Ultrasonography,  MRI, and dual X-ray absorptiometry revealed that the defects were filled with soft tissue. Grossly, the bones were abnormal in shape, and a gelatinous material filled the defects and the surrounding marrow cavity. Histologically, the gelatinous material was composed of fibrin and cartilage;  few normal bone cells were seen. Genetic testing revealed extra material on the short arm of chromosome 8 in all tissues examined, but no copy number alterations of likely clinical significance were observed, and no abnormalities were found that were unique to the lesions. In light of the  clinical signs and radiographic and pathologic findings, polyostotic fibrous dysplasia was diagnosed. This report represents the first documented case of fibrous dysplasia in a cynomolgus macaque.
authors.affiliation: Southwest National Primate Research Center, University of Texas Health Science Center at San Antonio, San Antoni, TX, USA. cbauer@txbiomed.org
authors.forename: Cassondra
authors.initials: C
authors.lastname: Bauer
authors.forename: Betty G
authors.initials: BG
authors.lastname: Dunn
authors.forename: Arthur R
authors.initials: AR
authors.lastname: Brothman
authors.forename: Edward J
authors.initials: EJ
authors.lastname: Dick
authors.forename: Chris
authors.initials: C
authors.lastname: Christensen
authors.forename: Andra
authors.initials: A
authors.lastname: Voges
authors.forename: Charleen M
authors.initials: CM
authors.lastname: Moore
mesh_terms: D015502:Absorptiometry, Photon / Q000662:veterinary; D000818:Animals; D001344:Autopsy / Q000662:veterinary; D001706:Biopsy / Q000662:veterinary; D005260:Female; D005359:Fibrous Dysplasia, Polyostotic / Q000662:veterinary*; D005360:Fibula / Q000000981:diagnostic imaging / Q000293:injuries* / Q000473:pathology; D008252:Macaca fascicularis / Q000235:genetics / Q000293:injuries; D008279:Magnetic Resonance Imaging / Q000662:veterinary; D008992:Monkey Diseases / Q000175:diagnosis* / Q000235:genetics / Q000473:pathology; D013978:Tibial Fractures / Q000662:veterinary; D014463:Ultrasonography