title: Phthalide and isocoumarin derivatives produced by an Acremonium sp. isolated from a mangrove Rhizophora apiculata.
abstract: Nine new fungal metabolites, one phthalide derivative, acremonide (1), and eight isocoumarin derivatives, acremonones A-H (2-9), were isolated from the mangrove-derived fungus Acremonium sp. PSU-MA70 together with 10 known compounds. Their structures were determined by NMR analysis. The known 8-deoxytrichothecin and trichodermol exhibited moderate antifungal activity against Candida albicans and Cryptococcus neoformanns, respectively.
authors.affiliation: Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Prince of Songkla University , Hat Yai, Songkhla 90112, Thailand. vatcharin.r@psu.ac.th
authors.forename: Vatcharin
authors.initials: V
authors.lastname: Rukachaisirikul
authors.forename: Aekkachai
authors.initials: A
authors.lastname: Rodglin
authors.forename: Yaowapa
authors.initials: Y
authors.lastname: Sukpondma
authors.forename: Souwalak
authors.initials: S
authors.lastname: Phongpaichit
authors.forename: Jirayu
authors.initials: J
authors.lastname: Buatong
authors.forename: Jariya
authors.initials: J
authors.lastname: Sakayaroj
mesh_terms: D000164:Acremonium / Q000737:chemistry*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification*; D002176:Candida albicans / Q000187:drug effects; D003455:Cryptococcus neoformans / Q000187:drug effects; D049934:Isocoumarins / Q000737:chemistry / Q000302:isolation & purification*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D043982:Rhizophoraceae / Q000382:microbiology*; D013785:Thailand
chemical_list: D000935:Antifungal Agents; D001572:Benzofurans; D049934:Isocoumarins; C574259:acremonide; C082022:phthalide