title: Alcohol abuse and glycoconjugate metabolism.
abstract: The relationship between alcohol consumption and glycoconjugate metabolism is complex and multidimensional. This review summarizes the advances in basic and clinical research on the molecular and cellular events involved in the metabolic effects of alcohol on glycoconjugates (glycoproteins, glycolipids, and proteoglycans). We summarize the action of ethanol, acetaldehyde, reactive oxygen species (ROS), nonoxidative metabolite of alcohol--fatty acid ethyl esters (FAEEs), and the ethanol-water competition mechanism, on glycoconjugate biosynthesis, modification, transport and secretion, as well as on elimination and catabolism processes. As the majority of changes in the cellular metabolism of glycoconjugates are generally ascribed to alterations in synthesis, transport, glycosylation and secretion, the degradation and elimination processes, of which the former occurs also in extracellular matrix, seem to be underappreciated. The pathomechanisms are additionally complicated by the fact that the effect of alcohol intoxication on the glycoconjugate metabolism depends not only on the duration of ethanol exposure, but also demonstrates dose- and regional-sensitivity. Further research is needed to bridge the gap in transdisciplinary research and enhance our understanding of alcohol- and glycoconjugate-related diseases.
authors.affiliation: Department of Psychiatry, Medical University of Bialystok, Plac Brodowicza 1, 16-070 Choroszcz, Poland. napoleonwas@yahoo.com
authors.forename: Napoleon
authors.initials: N
authors.lastname: Waszkiewicz
authors.forename: Sławomir Dariusz
authors.initials: SD
authors.lastname: Szajda
authors.forename: Anna
authors.initials: A
authors.lastname: Zalewska
authors.forename: Agata
authors.initials: A
authors.lastname: Szulc
authors.forename: Alina
authors.initials: A
authors.lastname: Kępka
authors.forename: Alina
authors.initials: A
authors.lastname: Minarowska
authors.forename: Marzena
authors.initials: M
authors.lastname: Wojewódzka-Żelezniakowicz
authors.forename: Beata
authors.initials: B
authors.lastname: Konarzewska
authors.forename: Sylwia
authors.initials: S
authors.lastname: Chojnowska
authors.forename: Jerzy Robert
authors.initials: JR
authors.lastname: Ladny
authors.forename: Krzysztof
authors.initials: K
authors.lastname: Zwierz
mesh_terms: D000437:Alcoholism / Q000378:metabolism*; D006001:Glycoconjugates / Q000378:metabolism*; D006801:Humans
chemical_list: D006001:Glycoconjugates