title: Recognition of damaged DNA: structure and dynamic markers.
abstract: DNA damage, a consequence of external factors and inherent metabolic processes, is omnipresent. Nature has devised multiple strategies to safeguard the genetic information and developed intricate repair mechanisms and pathways to reverse an array of different DNA lesions, including mismatches. Failure of the DNA repair systems may result in mutation, premature ageing, and cancer. In this review, we focus on structural and dynamic aspects of detection of lesions in base excision and mismatch repair. A thorough understanding of repair, pathways, and regulation is necessary to develop strategies for targeting DNA-related pathologies.
authors.affiliation: Department of Chemistry, Georgia State University, Atlanta, Georgia 30302, USA. mwg@gsu.edu
authors.forename: Markus W
authors.initials: MW
authors.lastname: Germann
authors.forename: Christopher N
authors.initials: CN
authors.lastname: Johnson
authors.forename: Alexander M
authors.initials: AM
authors.lastname: Spring
mesh_terms: D002843:Chromatin / Q000378:metabolism; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D004249:DNA Damage; D053843:DNA Mismatch Repair; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000378:metabolism; D003857:Deoxyuridine / Q000378:metabolism; D006147:Guanine / Q000031:analogs & derivatives / Q000378:metabolism; D006801:Humans; D008958:Models, Molecular; D051718:MutS Homolog 2 Protein / Q000378:metabolism; D051981:Uracil-DNA Glycosidase / Q000378:metabolism
chemical_list: C453560:7,8-dihydro-8-oxoguanine; D002843:Chromatin; D004268:DNA-Binding Proteins; C094443:G-T mismatch-binding protein; D006147:Guanine; D004247:DNA; D051981:Uracil-DNA Glycosidase; C497172:MSH2 protein, human; D051718:MutS Homolog 2 Protein; D003857:Deoxyuridine