title: Reversible diffusion weighted imaging changes in propionic acidemia.
abstract: Propionic acidemia is an inborn error of metabolism with neurologic manifestations. We describe a 3-year-old boy with propionic acidemia presenting with a metabolic crisis including headache, vomiting, and altered mental status with metabolic acidosis. Electroencephalography showed focal slowing in right temporal region. Magnetic resonance imaging (MRI) of the brain showed restricted diffusion with apparent diffusion coefficient correlate in the right parietooccipital region. Correction of metabolic acidosis led to clinical improvement and normalization of MRI diffusion weighted imaging/apparent diffusion coefficient changes. This article suggests that restricted diffusion resulting from metabolic crises in propionic acidemia may be reversible in some cases.
authors.affiliation: Department of Neurology, University at Buffalo, SUNY-Buffalo, Buffalo, NY, USA. akandel@buffalo.edu
authors.forename: Amit
authors.initials: A
authors.lastname: Kandel
authors.forename: Sirisa Kandel
authors.initials: SK
authors.lastname: Amatya
authors.forename: E Ann
authors.initials: EA
authors.lastname: Yeh
mesh_terms: D001772:Blood Cell Count; D002675:Child, Preschool; D056324:Diffusion Tensor Imaging / Q000379:methods*; D004569:Electroencephalography; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D056693:Propionic Acidemia / Q000175:diagnosis* / Q000378:metabolism*; D013702:Temporal Lobe / Q000378:metabolism / Q000473:pathology