title: Cost-effectiveness analysis of dronedarone versus other anti-arrhythmic drugs for the treatment of atrial fibrillation--results for Canada, Italy, Sweden and Switzerland.
abstract: The ATHENA clinical trial enrolled 4,628 patients in 37 countries and evaluated the efficacy of dronedarone 400 mg twice daily versus placebo for the prevention of cardiovascular hospitalisation or death from any cause in patients with paroxysmal or persistent atrial fibrillation or atrial flutter. The trial showed a statistically significant 24% reduction in the primary endpoint cardiovascular hospitalisations or all-cause death. In the current paper, parameters that drive the cost-effectiveness of dronedarone on top of standard therapy versus likely comparators, i.e. amiodarone, sotalol and flecainide, were investigated by means of a health economic model based on the ATHENA clinical trial. Dronedarone is cost-effective, and ICERs are low versus amiodarone with €5,340; €4,620; €3,850 and €5,630 per QALY gained for Canada, Italy, Sweden and Switzerland, respectively. The most significant driving factor for the cost-effectiveness of dronedarone is the increased survival rate for patients on dronedarone.
authors.affiliation: OptumInsight, Stockholm, Sweden. Jonas.nilsson@optum.com
authors.forename: Jonas
authors.initials: J
authors.lastname: Nilsson
authors.forename: Örjan
authors.initials: Ö
authors.lastname: Åkerborg
authors.forename: Gaëlle
authors.initials: G
authors.lastname: Bégo-Le Bagousse
authors.forename: Mårten
authors.initials: M
authors.lastname: Rosenquist
authors.forename: Peter
authors.initials: P
authors.lastname: Lindgren
mesh_terms: D000367:Age Factors; D000638:Amiodarone / Q000031:analogs & derivatives* / Q000191:economics / Q000627:therapeutic use; D000889:Anti-Arrhythmia Agents / Q000191:economics* / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000150:complications / Q000188:drug therapy*; D002170:Canada; D002318:Cardiovascular Diseases / Q000191:economics / Q000209:etiology; D003362:Cost-Benefit Analysis; D000077764:Dronedarone; D005060:Europe; D006304:Health Status; D006801:Humans; D018803:Models, Economic; D019057:Quality-Adjusted Life Years; D016032:Randomized Controlled Trials as Topic; D012737:Sex Factors; D016019:Survival Analysis
chemical_list: D000889:Anti-Arrhythmia Agents; D000077764:Dronedarone; D000638:Amiodarone