title: [Prognostic significance of lymphovascular invasion in upper urinary tract carcinoma: a retrospective monocentric analysis].
abstract: OBJECTIVE
  To analyze the prognostic impact of lymphovascular invasion (LVI) in case of urothelial carcinoma of upper urinary tract (UUT-UC).
  
  
  METHODS
  Retrospective study of 83 consecutive patients treated surgically for UUT-UC between January 1998 and October 2008. Prognostic interest of histopathological factors (stage, grade, LVI, CIS, tumor architecture, location, nodal status and surgical margins) was assessed in univariate and multivariate Cox regression model. Specific survival (SS), recurrence-free survival (RFS) and metastasis-free survival (MFS) were calculated using Kaplan-Meier method and Log-Rank test.
  
  
  RESULTS
  LVI was observed in 26.5% of patients after histopathologic reviewing. The SS, RFS and MFS at 2 years were 93%, 76% and 96% respectively in group without LVI compared to 40%, 13% and 38% in group with LVI (P<0.001). In univariate analysis, pathological stage, LVI and margin status were predictive of SS (P<0.05). Pathological stage, LVI and surgical margin status were predictive of RFS (P<0.05). LVI, tumor architecture and status of surgical margins were predictive of MFS (P<0.05). LVI was the only independent predictive factor in multivariate analysis for all survival (P=0.002, 0.002 and 0.001 respectively for the SS, RFS and MFS).
  
  
  CONCLUSIONS
  LVI was a poor prognostic factor in cases of UUT-UC. This criteria should be routinely sought and included in the pathology report.
authors.affiliation: Service d'urologie, hôpital Claude-Huriez, CHRU de Lille, université Lille Nord-de-France, rue Michel-Polonovski, 59037 Lille cedex, France. pierre colin@msn.com
authors.forename: P
authors.initials: P
authors.lastname: Colin
authors.forename: M
authors.initials: M
authors.lastname: Verhasselt-Crinquette
authors.forename: A
authors.initials: A
authors.lastname: Ouzzane
authors.forename: R
authors.initials: R
authors.lastname: Yakoubi
authors.forename: C
authors.initials: C
authors.lastname: Bouchery
authors.forename: S
authors.initials: S
authors.lastname: Debrock
authors.forename: J-C
authors.initials: JC
authors.lastname: Fantoni
authors.forename: A
authors.initials: A
authors.lastname: Villers
authors.forename: X
authors.initials: X
authors.lastname: Leroy
mesh_terms: D000368:Aged; D002295:Carcinoma, Transitional Cell / Q000401:mortality / Q000473:pathology* / Q000556:secondary*; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000401:mortality / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D014516:Ureteral Neoplasms / Q000401:mortality / Q000473:pathology*; D019043:Vascular Neoplasms / Q000401:mortality / Q000473:pathology*