title: Senescence in chronic obstructive pulmonary disease.
abstract: There is a growing realization that chronic obstructive pulmonary disease involves several processes present in aging and cellular senescence. The impact of these processes in the pathogenesis of the main manifestations is multiple, particularly in the propagation of a proinflammatory phenotype, loss of reparative potential, and amplification of oxidative stress, all ultimately leading to tissue damage. This review highlights salient aspects related to senescence discussed in the 2011 Aspen Lung Conference.
authors.affiliation: Department of Medicine, University of Colorado School of Medicine, Aurora, Colorado, USA. Rubin.Tuder@ucdenver.edu
authors.forename: Rubin M
authors.initials: RM
authors.lastname: Tuder
authors.forename: Jeffrey A
authors.initials: JA
authors.lastname: Kern
authors.forename: York E
authors.initials: YE
authors.lastname: Miller
mesh_terms: D016922:Cellular Senescence / Q000276:immunology*; D006801:Humans; D008168:Lung / Q000276:immunology / Q000378:metabolism; D018384:Oxidative Stress / Q000276:immunology*; D029424:Pulmonary Disease, Chronic Obstructive / Q000276:immunology* / Q000378:metabolism*