title: Quantitative ultrasound bone measurements in pre-pubertal children with type 1 diabetes.
abstract: This case-control study aimed to assess bone status in children with type 1 diabetes mellitus (T1DM). Fifty-seven pre-pubertal patients (37 boys, aged 7.9 ± 2.5 years, T1DM duration 3.1 ± 1.6 years) and 171 age-matched healthy controls (111 boys) were studied. Quantitative ultrasound (QUS) was used to measure amplitude dependent speed of sound (Ad-SoS) at hand phalanges (expressed as standard deviation score [SDS]). Anthropometric and disease-related data (including mean HbA(1c) from whole T1DM duration [T], last year [Y], examination day [D]) were collected. Mean Ad-SoS SDS in patients -0.13 ± 1.32 (95% confidence interval [CI] -0.48, 0.22) was similar to that of controls. Subgroups discriminated according to HbA(1c) D, Y and T (cut-off 7.0%) did not differ regarding analyzed parameters. In patients, Ad-SoS SDS was comparable for both genders. Multivariable stepwise regression analysis showed significant negative influence of diabetes duration on Ad-SoS SDS. QUS findings in pre-pubertal children with T1DM do not differ from those in healthy children. Disease duration seems to affect negatively Ad-SoS SDS. However, independent prospective studies are needed to elucidate the true associations.
authors.affiliation: Department of Paediatrics, Clinical Hospital No. 1, Zabrze, Poland. agata.chobot@gmail.com
authors.forename: Agata P
authors.initials: AP
authors.lastname: Chobot
authors.forename: Anna
authors.initials: A
authors.lastname: Haffke
authors.forename: Joanna
authors.initials: J
authors.lastname: Polanska
authors.forename: Zenon P
authors.initials: ZP
authors.lastname: Halaba
authors.forename: Grazyna
authors.initials: G
authors.lastname: Deja
authors.forename: Przemyslawa
authors.initials: P
authors.lastname: Jarosz-Chobot
authors.forename: Wojciech
authors.initials: W
authors.lastname: Pluskiewicz
mesh_terms: D001842:Bone and Bones / Q000000981:diagnostic imaging*; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D008297:Male; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014463:Ultrasonography