title: Correlations of circulating peptide YY and ghrelin with body weight, rate of weight gain, and time required to achieve the recommended daily intake in preterm infants.
abstract: The objective was to elucidate the relationships between serum concentrations of the gut hormone peptide YY (PYY) and ghrelin and growth development in infants for potential application to the clinical observation index. Serum concentrations of PYY and ghrelin were measured using radioimmunoassay from samples collected at the clinic. For each patient, gestational age, birth weight, time required to return to birth weight, rate of weight gain, time required to achieve recommended daily intake (RDI) standards, time required for full-gastric feeding, duration of hospitalization, and time of administration of total parenteral nutrition were recorded. Serum PYY and ghrelin concentrations were significantly higher in the preterm group (N = 20) than in the full-term group (N = 20; P < 0.01). Within the preterm infant group, the serum concentrations of PYY and ghrelin on postnatal day (PND) 7 (ghrelin = 1485.38 ± 409.24; PYY = 812.37 ± 153.77 ng/L) were significantly higher than on PND 1 (ghrelin = 956.85 ± 223.09; PYY = 545.27 ± 204.51 ng/L) or PND 3 (ghrelin = 1108.44 ± 351.36; PYY = 628.96 ± 235.63 ng/L; P < 0.01). Both serum PYY and ghrelin concentrations were negatively correlated with body weight, and the degree of correlation varied with age. Serum ghrelin concentration correlated negatively with birth weight and positively with the time required to achieve RDI (P < 0.05). In conclusion, serum PYY and ghrelin concentrations reflect a negative energy balance, predict postnatal growth, and enable compensation. Further studies are required to elucidate the precise concentration and roles of PYY and ghrelin in newborns and to determine the usefulness of measuring these hormones in clinical practice.
authors.affiliation: Department of Pediatrics, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China.
authors.forename: XiaFang
authors.initials: X
authors.lastname: Chen
authors.forename: XueLiang
authors.initials: X
authors.lastname: Du
authors.forename: JianXing
authors.initials: J
authors.lastname: Zhu
authors.forename: LiJuan
authors.initials: L
authors.lastname: Xie
authors.forename: YongJun
authors.initials: Y
authors.lastname: Zhang
authors.forename: ZhenJuan
authors.initials: Z
authors.lastname: He
mesh_terms: D001835:Body Weight / Q000502:physiology*; D016022:Case-Control Studies; D002149:Energy Intake / Q000502:physiology*; D005260:Female; D054439:Ghrelin / Q000097:blood*; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature / Q000502:physiology*; D008297:Male; D009751:Nutritional Requirements / Q000502:physiology*; D019894:Peptide YY / Q000097:blood*; D011863:Radioimmunoassay; D015430:Weight Gain / Q000502:physiology*
chemical_list: D054439:Ghrelin; D019894:Peptide YY