title: Brain natriuretic peptide in term pregnancy.
abstract: OBJECTIVE
  To determine the normal range of serum brain natriuretic peptide (BNP) in uncomplicated, singleton term pregnant patients.
  
  
  METHODS
  Serum for analysis of BNP was drawn at admission to labor and delivery (= 104), prior to administration of intravenous fluid.
  
  
  RESULTS
  Median BNP was 20 pg/mL, with an interquartile range of 20 pg/mL (range 5-70 pg/mL; or a mean ± standard deviation [SD] of 23 ± 16 pg/mL). Brain natriuretic peptide negatively correlated with prepregnant (r = -.24, P < .05) and pregnant weight (r = -26, P < .01) and with heart rate (r = -.35, P < 0.001); heart rate was also positively correlated with BMI (r = .32). Brain natriuretic peptide levels were higher in Hispanic than African American women, independent of body mass index (BMI) and heart rate.
  
  
  CONCLUSIONS
  Brain natriuretic peptide values found in term pregnant patients are similar to those of prepregnant women of reproductive age. Brain natriuretic peptide levels appear to be set by conditions present in the prepregnant condition and maintained, despite changes in plasma volume, systemic vascular resistance, and cardiac output.
authors.affiliation: Department of Obstetrics and Gynecology, Division of Maternal Fetal Medicine, Hackensack University Medical Center, University of Medicine and Dentistry of New Jersey--New Jersey Medical School, Hackensack, NJ, USA. ladinyurterikaplan@gmail.com
authors.forename: Ladin
authors.initials: L
authors.lastname: Yurteri-Kaplan
authors.forename: Shelley
authors.initials: S
authors.lastname: Saber
authors.forename: Stacy
authors.initials: S
authors.lastname: Zamudio
authors.forename: Deepak
authors.initials: D
authors.lastname: Srinivasan
authors.forename: Themba
authors.initials: T
authors.lastname: Nyirenda
authors.forename: Manuel
authors.initials: M
authors.lastname: Alvarez
authors.forename: Abdulla
authors.initials: A
authors.lastname: Al-Khan
mesh_terms: D000293:Adolescent; D000328:Adult; D001741:Black or African American; D001213:Asian; D015992:Body Mass Index; D001835:Body Weight; D005260:Female; D006339:Heart Rate; D006630:Hispanic or Latino; D006801:Humans; D007743:Labor, Obstetric / Q000097:blood*; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D011247:Pregnancy; D012016:Reference Values; D044465:White People
chemical_list: D020097:Natriuretic Peptide, Brain