title: Simplification to monotherapy with lopinavir/ritonavir in adolescents with vertically acquired HIV-1 infection.
abstract: In recent years, the use of boosted protease inhibitors monotherapy has become increasingly important, especially considering the advantages in terms of costs, tolerability, and simplification. Despite that, knowledge about the efficacy and safety of this approach  in HIV-1-infected adolescents who have acquired HIV-1 infection through perinatal transmission is still limited. We report here our experience with two adolescents who have been successfully treated with lopinavir/ritonavir monotherapy.
authors.affiliation: Clinica Malattie Infettive, University of Genoa, San Martino Hospital, Italy.
authors.forename: Eva
authors.initials: E
authors.lastname: Schenone
authors.forename: Antonio
authors.initials: A
authors.lastname: Di Biagio
authors.forename: Andrea
authors.initials: A
authors.lastname: Parisini
authors.forename: Bianca
authors.initials: B
authors.lastname: Bruzzone
authors.forename: Laura
authors.initials: L
authors.lastname: Sticchi
authors.forename: Anna
authors.initials: A
authors.lastname: Calzi
authors.forename: Elena
authors.initials: E
authors.lastname: Nicco
authors.forename: Giovanni
authors.initials: G
authors.lastname: Secondo
authors.forename: Claudio
authors.initials: C
authors.lastname: Viscoli
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000635:transmission* / Q000821:virology; D017320:HIV Protease Inhibitors / Q000627:therapeutic use*; D015497:HIV-1 / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D061466:Lopinavir / Q000627:therapeutic use*; D008297:Male; D012367:RNA, Viral / Q000235:genetics; D019438:Ritonavir / Q000627:therapeutic use*; D016896:Treatment Outcome; D019562:Viral Load; D055815:Young Adult
chemical_list: D017320:HIV Protease Inhibitors; D012367:RNA, Viral; D061466:Lopinavir; D019438:Ritonavir