title: Exploring ART intake scenes in a human rights-based intervention to improve adherence: a randomized controlled trial.
abstract: To assess the effectiveness of a psychosocial individual intervention to improve adherence to ART in a Brazilian reference-center, consenting PLHIV with viral load >50 copies/ml were selected. After 4 weeks of MEMS cap use, participants were randomized into an intervention group (IG) (n = 64) or control group (CG) (n = 57). CG received usual care only. The IG participated in a human rights-based intervention approach entailing four dialogical meetings focused on medication intake scenes. Comparison between IG and CG revealed no statistically significant difference in adherence measured at weeks 8, 12, 16, 20 and 24. Viral load (VL) decreased in both groups (p < 0.0001) with no significant difference between study groups. The lower number of eligible patients than expected underpowered the study. Ongoing qualitative analysis should provide deeper understanding of the trial results. NIH Clinical Trials: NCT00716040.
authors.affiliation: Reference and Training Center for Sexually Transmitted Infection and Acquired Immunodeficiency Syndrome, Rua Santa Cruz, 81, Vila Mariana, São Paulo, SP, CEP: 4112-000, Brazil. cr_basso@terra.com.br
authors.forename: Cáritas Relva
authors.initials: CR
authors.lastname: Basso
authors.forename: Ernani Tiaraju Santa
authors.initials: ET
authors.lastname: Helena
authors.forename: Joselita Maria Magalhães
authors.initials: JM
authors.lastname: Caraciolo
authors.forename: Vera
authors.initials: V
authors.lastname: Paiva
authors.forename: Maria Ines Battistela
authors.initials: MI
authors.lastname: Nemes
mesh_terms: D000293:Adolescent; D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage*; D023241:Antiretroviral Therapy, Highly Active / Q000379:methods* / Q000523:psychology; D001938:Brazil; D018791:CD4 Lymphocyte Count; D005260:Female; D015658:HIV Infections / Q000188:drug therapy* / Q000523:psychology* / Q000821:virology; D006806:Human Rights; D006801:Humans; D008297:Male; D055118:Medication Adherence / Q000523:psychology*; D008875:Middle Aged; D017063:Outcome Assessment, Health Care; D012944:Social Support; D012959:Socioeconomic Factors; D019562:Viral Load; D055815:Young Adult; D016903:Drug Monitoring
chemical_list: D019380:Anti-HIV Agents