title: Small leucine rich proteoglycan family regulates multiple signalling pathways in neural development and maintenance.
abstract: The small leucine-rich repeat proteoglycan (SLRPs) family of proteins currently consists of five classes, based on their structural composition and chromosomal location. As biologically active components of the extracellular matrix (ECM), SLRPs were known to bind to various collagens, having a role in regulating fibril assembly, organization and degradation. More recently, as a function of their diverse proteins cores and glycosaminoglycan side chains, SLRPs have been shown to be able to bind various cell surface receptors, growth factors, cytokines and other ECM components resulting in the ability to influence various cellular functions. Their involvement in several signaling pathways such as Wnt, transforming growth factor-β and epidermal growth factor receptor also highlights their role as matricellular proteins. SLRP family members are expressed during neural development and in adult neural tissues, including ocular tissues. This review focuses on describing SLRP family members involvement in neural development with a brief summary of their role in non-neural ocular tissues and in response to neural injury.
authors.affiliation: University College London (UCL) Institute of Ophthalmology, UCL, London, UK.
authors.forename: Margaret
authors.initials: M
authors.lastname: Dellett
authors.forename: Wanzhou
authors.initials: W
authors.lastname: Hu
authors.forename: Vasiliki
authors.initials: V
authors.lastname: Papadaki
authors.forename: Shin-ichi
authors.initials: S
authors.lastname: Ohnuma
mesh_terms: D000818:Animals; D058575:Decorin / Q000378:metabolism*; D047108:Embryonic Development; D005109:Extracellular Matrix / Q000378:metabolism / Q000502:physiology; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D000090263:Leucine-Rich Repeat Proteins; D058953:Neural Stem Cells / Q000166:cytology / Q000378:metabolism; D055495:Neurogenesis; D011485:Protein Binding; D011506:Proteins / Q000378:metabolism*; D012160:Retina / Q000166:cytology / Q000196:embryology / Q000293:injuries / Q000378:metabolism; D055153:Stem Cell Niche; D016212:Transforming Growth Factor beta / Q000378:metabolism; D060449:Wnt Signaling Pathway
chemical_list: D058575:Decorin; D016326:Extracellular Matrix Proteins; D000090263:Leucine-Rich Repeat Proteins; D011506:Proteins; D016212:Transforming Growth Factor beta