title: Biomarker discovery in human cerebrospinal fluid: the need for integrative metabolome and proteome databases.
abstract: The number of metabolites identified in human cerebrospinal fluid (CSF) has steadily increased over the past 5 years, and in this issue of Genome Medicine David Wishart and colleagues provide a comprehensive update that brings the number of metabolites listed in the CSF metabolome database to 476 compounds. There is now a need for an integrative metabolome-proteome CSF database to maximize the impact of this achievement in biomedical research. Only by such efforts can we hope to unravel the complexity of molecular pathophysiological processes.
authors.affiliation: Institute of Biotechnology, University of Cambridge, Cambridge CB2 1QT, UK. pg110@cam.ac.uk.
authors.forename: Emanuel
authors.initials: E
authors.lastname: Schwarz
authors.forename: E Fuller
authors.initials: EF
authors.lastname: Torrey
authors.forename: Paul C
authors.initials: PC
authors.lastname: Guest
authors.forename: Sabine
authors.initials: S
authors.lastname: Bahn