title: Diffusion sensitivity of turbo spin echo sequences.
abstract: This article introduces an effective b-factor b(TSE) for turbo spin echo (TSE) sequences to quantify their inherent diffusion sensitivity. b(TSE) is investigated for a broad variety of two-dimensional- and three-dimensional-TSE sequences using constant and varying flip angles (transitions between pseudo steady states, SPACE, VISTA, Cube, etc.). The inherent TSE diffusion sensitivity becomes important for high-resolution protocols, which can lead to subtle contrast modifications or even fluid suppressions in a clinical setting or animal imaging regime. The b(TSE) values obtained considerably depend on the relaxation times and diffusion coefficient and, thus, on the tissue under observation. The fractional b(TSE) contributions per TSE imaging encoding axis are highly anisotropic. Further noteworthy effects such as decreasing b-factors along a TSE train are pointed out and explained. The results are also discussed in combination with recent findings regarding contrast properties and possible diffusion sensitivity of TSE sequences. Identical but well more pronounced b(TSE) effects are observed in the animal imaging regime due to smaller field of view and higher resolutions.
authors.affiliation: Department of Radiology, Medical Physics, University Medical Center Freiburg, Freiburg, Germany. matthias.weigel@uniklinik-freiburg.de
authors.forename: Matthias
authors.initials: M
authors.lastname: Weigel
authors.forename: Jürgen
authors.initials: J
authors.lastname: Hennig
mesh_terms: D000465:Algorithms; D003198:Computer Simulation; D038524:Diffusion Magnetic Resonance Imaging / Q000379:methods*; D017352:Echo-Planar Imaging / Q000379:methods*; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007090:Image Interpretation, Computer-Assisted / Q000379:methods*; D021621:Imaging, Three-Dimensional / Q000379:methods*; D008954:Models, Biological; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013113:Spin Labels
chemical_list: D013113:Spin Labels