title: Jararhagin, a hemorrhagic snake venom metalloproteinase from Bothrops jararaca.
abstract: Jararhagin is a metalloproteinase isolated from Bothrops jararaca snake venom, which has been extensively studied. These studies showed its involvement on most of the systemic and local damaging effects of snakebite envenomings. In this review we comment on the major targets of jararhagin as the vascular endothelium, platelets and coagulation factors and also its action on other cell systems as inflammatory cells and their mediators, cancer and cell signaling. The mechanisms of jararhagin action are discussed together with structural features essential for the expression of its biological activities. The studies reviewed here denote jararhagin as a prototype for studies of snake venom metalloproteinases, bringing new insights into cellular-matrix interactions and adding for the improvement of snakebite treatment.
authors.affiliation: Laboratório de Imunopatologia, Instituto Butantan, Av. Vital Brasil 1500, CEP-05503-900 São Paulo, SP, Brazil. anamoura@butantan.gov.br
authors.forename: Ana M
authors.initials: AM
authors.lastname: Moura-da-Silva
authors.forename: Cristiani
authors.initials: C
authors.lastname: Baldo
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D001665:Binding Sites; D017837:Bothrops / Q000378:metabolism*; D001938:Brazil; D002448:Cell Adhesion / Q000187:drug effects; D003094:Collagen / Q000737:chemistry / Q000378:metabolism; D003435:Crotalid Venoms / Q000737:chemistry / Q000201:enzymology* / Q000378:metabolism / Q000494:pharmacology; D042783:Endothelial Cells / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D016023:Integrins / Q000737:chemistry / Q000378:metabolism; D008264:Macrophages / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D008666:Metalloendopeptidases / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D011487:Protein Conformation; D030162:Reptilian Proteins / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D000097146:Bothrops jararaca Venom
chemical_list: D000925:Anticoagulants; D003094:Collagen; D003435:Crotalid Venoms; D018836:Inflammation Mediators; D016023:Integrins; D008666:Metalloendopeptidases; D010975:Platelet Aggregation Inhibitors; D030162:Reptilian Proteins; D000097146:Bothrops jararaca Venom