title: Metabolomic study of plasma of patients with abdominal aortic aneurysm.
abstract: Abdominal aortic aneurysm (AAA) is an important health problem, both because of AAA rupture and death and because of increased cardiovascular mortality. Identification of new biomarkers of AAA may suggest novel pathological mechanisms and targets for new medical treatments to slow AAA progression. Metabolic changes in AAA patients were mainly related to carbohydrate and lipid metabolism and many of these changes can be associated with a situation of insulin resistance (which can be related to metabolic syndrome) together with altered amino acid metabolism. For the first time, metabolites that can be associated with differential metabolism by the gut microflora of AAA patients have also been found. Moreover, aminomalonic acid in plasma has been shown to be the metabolite with the biggest difference between patients suffering from large aneurysm (>5 cm) and controls.
authors.affiliation: Cembio, Pharmacy Faculty, Campus Monteprincipe, San Pablo-CEU University, 28668 Boadilla del Monte, Spain.
authors.forename: Francisco J
authors.initials: FJ
authors.lastname: Rupérez
authors.forename: Priscila
authors.initials: P
authors.lastname: Ramos-Mozo
authors.forename: Joanna
authors.initials: J
authors.lastname: Teul
authors.forename: Roxana
authors.initials: R
authors.lastname: Martinez-Pinna
authors.forename: Antonia
authors.initials: A
authors.lastname: Garcia
authors.forename: Myriam
authors.initials: M
authors.lastname: Malet-Martino
authors.forename: Emilio
authors.initials: E
authors.lastname: Camafeita
authors.forename: Juan Antonio
authors.initials: JA
authors.lastname: Lopez
authors.forename: Carlos
authors.initials: C
authors.lastname: Pastor-Vargas
authors.forename: Jesús
authors.initials: J
authors.lastname: Egido
authors.forename: Stéphane
authors.initials: S
authors.lastname: Balayssac
authors.forename: Véronique
authors.initials: V
authors.lastname: Gilard
authors.forename: Coral
authors.initials: C
authors.lastname: Barbas
authors.forename: Jose Luis
authors.initials: JL
authors.lastname: Martin-Ventura
mesh_terms: D017544:Aortic Aneurysm, Abdominal / Q000097:blood*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D055432:Metabolomics