title: Effect of methylsulfonylmethane supplementation on exercise - Induced muscle damage and total antioxidant capacity.
abstract: OBJECTIVE
  The aim of this study was to evaluate effect of 10-day methylsulfonylmethane (MSM) supplementation on exercise-induced muscle damage.
  
  
  METHODS
  Eighteen healthy, non-smoking, active young men were recruited to participate in this study. Participants were randomized in a double-blind placebo-controlled fashion into two groups: MSM (M) (N.=9) and placebo (P) (N.=9). Subjects consumed daily either placebo (200 mL water) or MSM supplement (50 mg/kg MSM in 200 mL water) for 10 days. Afterward, participants ran 14 km. Blood samples were taken before supplementation, before exercise, immediately, 30 min, 2, 24 and 48 h after exercise.
  
  
  RESULTS
  CK and bilirubin significantly increased in P group 24 h after exercise compared to M group (P=0.041 and P=0.002, respectively). TAC increased immediately post, 30 min, 2 and 24 h after exercise just in M group (P<0.05). TAC showed significant increase in M group 2 and 24 h after exercise compared to P group (P=0.014 and P=0.033, respectively).
  
  
  CONCLUSIONS
  It seems that 10-day supplementation with MSM has allowed to decrease muscle damage via effect on antioxidant capacity.
authors.affiliation: Islamic Azad University-Ardabil branch, Ardabil, Iran.
authors.forename: S
authors.initials: S
authors.lastname: Barmaki
authors.forename: S
authors.initials: S
authors.lastname: Bohlooli
authors.forename: F
authors.initials: F
authors.lastname: Khoshkhahesh
authors.forename: B
authors.initials: B
authors.lastname: Nakhostin-Roohi
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D001663:Bilirubin / Q000097:blood; D003402:Creatine Kinase / Q000097:blood; D019587:Dietary Supplements; D004121:Dimethyl Sulfoxide / Q000008:administration & dosage / Q000494:pharmacology*; D004311:Double-Blind Method; D015444:Exercise / Q000502:physiology*; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000293:injuries* / Q000502:physiology; D012420:Running / Q000293:injuries / Q000502:physiology; D013450:Sulfones / Q000008:administration & dosage / Q000494:pharmacology*; D055815:Young Adult
chemical_list: D000975:Antioxidants; D013450:Sulfones; C025910:dimethyl sulfone; D003402:Creatine Kinase; D001663:Bilirubin; D004121:Dimethyl Sulfoxide