title: An efficient synthetic approach to 6,5'-(S)- and 6,5'-(R)-cyclouridine.
abstract: Here we present new routes for the efficient syntheses of 6,5'-(S)- and 6,5'-(R)-cyclouridine. The syntheses utilize readily accessible uridine as a starting material. This route to the R diastereomer is significantly more efficient than previous synthetic efforts, allowing us to obtain large amounts of pure material for future biological testing.
authors.affiliation: Merkert Chemistry Center, 2609 Beacon Street, Chestnut Hill, MA, USA.
authors.forename: Christopher S
authors.initials: CS
authors.lastname: Theile
authors.forename: Larry W
authors.initials: LW
authors.lastname: McLaughlin
mesh_terms: D060326:Chemistry Techniques, Synthetic / Q000191:economics / Q000379:methods; D008958:Models, Molecular; D013237:Stereoisomerism; D014529:Uridine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry
chemical_list: C007208:cyclouridine; D014529:Uridine