title: Association between the Ku70-1310C/G promoter polymorphism and cancer risk: a meta-analysis.
abstract: Ku70 plays an important role in DNA double-strand break repair. Studies revealing conflicting results on the role of the Ku70-1310C/G promoter polymorphism on cancer risk led us to perform a meta-analysis to investigate this relationship. Ten case-control studies with 2566 cases and 3058 controls were identified. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of associations. The overall results suggested no association between the Ku70-1310C/G promoter polymorphism and total cancer risk. However, on stratified analysis, significantly increased risks were observed among the Asian population (GG vs. CC: OR=1.50, 95%CI=1.10-2.06; GG vs. CC/CG: OR=1.47, 95%CI=1.07-2.01) and population-based case- control studies (GG vs. CC: OR=1.57, 95%CI=1.12-2.22; CG vs. CC: OR=1.35, 95%CI=1.11-1.64; CG/GG vs. CC: OR=1.37, 95%CI=1.14-1.65). Additionally, variant genotypes were associated with a significantly increased breast cancer risk (GG vs. CC: OR=1.80, 95%CI=1.26-2.56; GG vs. CC/CG: OR=1.40, 95%CI=1.01-1.95).
authors.affiliation: Department of Breast Surgery, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China.
authors.forename: Lu
authors.initials: L
authors.lastname: Xu
authors.forename: Xiao-Bing
authors.initials: XB
authors.lastname: Ju
authors.forename: Pu
authors.initials: P
authors.lastname: Li
authors.forename: Jue
authors.initials: J
authors.lastname: Wang
authors.forename: Zhu-Mei
authors.initials: ZM
authors.lastname: Shi
authors.forename: Ming-Jie
authors.initials: MJ
authors.lastname: Zheng
authors.forename: Dan-Dan
authors.initials: DD
authors.lastname: Xue
authors.forename: Yan-jie
authors.initials: YJ
authors.lastname: Xu
authors.forename: Yong-mei
authors.initials: YM
authors.lastname: Yin
authors.forename: Shui
authors.initials: S
authors.lastname: Wang
authors.forename: Yong-Ping
authors.initials: YP
authors.lastname: You
mesh_terms: D034961:Antigens, Nuclear / Q000235:genetics*; D016022:Case-Control Studies; D004268:DNA-Binding Proteins / Q000235:genetics*; D006801:Humans; D000072200:Ku Autoantigen; D009369:Neoplasms / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D011379:Prognosis; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012307:Risk Factors
chemical_list: D034961:Antigens, Nuclear; D004268:DNA-Binding Proteins; C000606509:Xrcc6 protein, human; D000072200:Ku Autoantigen