title: Beyond azide-alkyne click reaction: easy access to 18F-labelled compounds via nitrile oxide cycloadditions.
abstract: Radiofluorinated 4-fluorobenzonitrile oxide and N-hydroxy-4-fluorobenzimidoyl chloride rapidly react with different alkenes and alkynes under mild conditions. These cycloadditions are suitable for the preparation of low-molecular weight radiopharmaceuticals and, in a strain-promoted variant, can enable easy labelling of sensitive biopolymers.
authors.affiliation: Klinik für Nuklearmedizin, Aachen University, RWTH, Pauwelsstr. 30, 52074 Aachen, Germany.
authors.forename: Boris D
authors.initials: BD
authors.lastname: Zlatopolskiy
authors.forename: René
authors.initials: R
authors.lastname: Kandler
authors.forename: Diana
authors.initials: D
authors.lastname: Kobus
authors.forename: Felix M
authors.initials: FM
authors.lastname: Mottaghy
authors.forename: Bernd
authors.initials: B
authors.lastname: Neumaier
mesh_terms: D000480:Alkynes / Q000737:chemistry*; D001386:Azides / Q000737:chemistry*; D057930:Click Chemistry; D003500:Cyclization; D005462:Fluorine Radioisotopes / Q000737:chemistry*; D009570:Nitriles / Q000737:chemistry*; D010087:Oxides / Q000737:chemistry*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000480:Alkynes; D001386:Azides; D005462:Fluorine Radioisotopes; D009570:Nitriles; D010087:Oxides; D019275:Radiopharmaceuticals