title: Cytosolic double-stranded DNA as a damage-associated molecular pattern induces the inflammatory response in rat pancreatic stellate cells: a plausible mechanism for tissue injury-associated pancreatitis.
abstract: Pancreatitis is an inflammatory disease of unknown causes. There are many triggers causing pancreatitis, such as alcohol, common bile duct stone, virus and congenital or acquired stenosis of main pancreatic duct, which often involve tissue injuries. Pancreatitis often occurs in sterile condition, where the dead/dying pancreatic parenchymal cells and the necrotic tissues derived from self-digested-pancreas were observed. However, the causal relationship between tissue injury and pancreatitis and how tissue injury could induce the inflammation of the pancreas were not elucidated fully until now. This study demonstrates that cytosolic double-stranded DNA increases the expression of several inflammatory genes (cytokines, chemokines, type I interferon, and major histocompatibility complex) in rat pancreatic stellate cells. Furthermore, these increase accompanied the multiple signal molecules genes, such as interferon regulatory factors, nuclear factor-kappa B, low-molecular-weight protein 2, and transporter associated with antigen processing 1. We suggest that this phenomenon is a plausible mechanism that might explain how cell damage of the pancreas or tissue injury triggers acute, chronic, and autoimmune pancreatitis; it is potentially relevant to host immune responses induced during alcohol consumption or other causes.
authors.affiliation: Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
authors.forename: Taichi
authors.initials: T
authors.lastname: Nakamura
authors.forename: Tetsuhide
authors.initials: T
authors.lastname: Ito
authors.forename: Hisato
authors.initials: H
authors.lastname: Igarashi
authors.forename: Masahiko
authors.initials: M
authors.lastname: Uchida
authors.forename: Masayuki
authors.initials: M
authors.lastname: Hijioka
authors.forename: Takamasa
authors.initials: T
authors.lastname: Oono
authors.forename: Nao
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authors.lastname: Fujimori
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Niina
authors.forename: Koichi
authors.initials: K
authors.lastname: Suzuki
authors.forename: Robert T
authors.initials: RT
authors.lastname: Jensen
authors.forename: Ryoichi
authors.initials: R
authors.lastname: Takayanagi