title: Low microsomal epoxide hydrolase expression is associated with bladder carcinogenesis and recurrence.
abstract: Microsomal epoxide hydrolase (mEH) plays a significant role in the metabolism of numerous xenobiotics and is associated with several forms of cancer. Here, we investigated the role of mEH expression in bladder carcinogenesis, subsequent progression and recurrence. The expression of mEH was analyzed by Western blot in 50 bladder urothelial carcinoma and 20 normal epithelial tissues. There was a significantly higher mEH expression in the normal epithelium (P<0.05) and mEH expression was lower in high stage than in low stage tumors (P<0.05). Further, immunohistochmistry in 106 bladder urothelial carcinoma demonstrated mEH expression to be negatively correlated with histological grade, pT stage and recurrence (P<0.05). These findings suggest the important role of mEH in bladder carcinogenesis, cancer development and recurrence, providing support for efforts to develop mEH-based gene therapy.
authors.affiliation: Department of Urology, The First Hospital of China Medical University, Shenyang, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Zhang
authors.forename: Xiu-Yue
authors.initials: XY
authors.lastname: Yu
authors.forename: Guo-Jun
authors.initials: GJ
authors.lastname: Zhang
authors.forename: Kun-Feng
authors.initials: KF
authors.lastname: Guo
authors.forename: Chui-Ze
authors.initials: CZ
authors.lastname: Kong
mesh_terms: D000328:Adult; D000368:Aged; D015153:Blotting, Western; D016022:Case-Control Studies; D018450:Disease Progression; D004851:Epoxide Hydrolases / Q000378:metabolism*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000201:enzymology* / Q000401:mortality / Q000473:pathology*; D009367:Neoplasm Staging; D011379:Prognosis; D015996:Survival Rate; D001743:Urinary Bladder / Q000201:enzymology; D001749:Urinary Bladder Neoplasms / Q000201:enzymology* / Q000401:mortality / Q000473:pathology*
chemical_list: D004851:Epoxide Hydrolases