title: Synthesis and cytotoxic activity of new acridine-thiazolidine derivatives.
abstract: Although their exact role in controlling tumour growth and apoptosis in humans remains undefined, acridine and thiazolidine compounds have been shown to act as tumour suppressors in most cancers. Based on this finding, a series of novel hybrid 5-acridin-9-ylmethylene-3-benzyl-thiazolidine-2,4-diones were synthesised via N-alkylation and Michael reaction. The cell viability was analysed using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, and DNA interaction assays were performed using electrochemical techniques.
authors.affiliation: Departamento de Fisiologia e Farmacologia, Faculdade de Medicina, Universidade Federal do Ceará, Fortaleza, Ceará, Brazil.
authors.forename: Francisco W A
authors.initials: FW
authors.lastname: Barros
authors.forename: Teresinha Gonçalves
authors.initials: TG
authors.lastname: Silva
authors.forename: Marina Galdino
authors.initials: MG
authors.lastname: da Rocha Pitta
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Bezerra
authors.forename: Letícia V
authors.initials: LV
authors.lastname: Costa-Lotufo
authors.forename: Manoel Odorico
authors.initials: MO
authors.lastname: de Moraes
authors.forename: Cláudia
authors.initials: C
authors.lastname: Pessoa
authors.forename: Maria Aline F B
authors.initials: MA
authors.lastname: de Moura
authors.forename: Fabiane C
authors.initials: FC
authors.lastname: de Abreu
authors.forename: Maria do Carmo Alves
authors.initials: Mdo C
authors.lastname: de Lima
authors.forename: Suely Lins
authors.initials: SL
authors.lastname: Galdino
authors.forename: Ivan da Rocha
authors.initials: Ida R
authors.lastname: Pitta
authors.forename: Marilia O F
authors.initials: MO
authors.lastname: Goulart
mesh_terms: D000166:Acridines / Q000737:chemistry*; D000478:Alkylation; D000677:Amsacrine / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D015374:Biosensing Techniques; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D004247:DNA / Q000032:analysis / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D055664:Electrochemical Techniques; D006801:Humans; D015394:Molecular Structure; D053778:Thiazolidines / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000166:Acridines; D000970:Antineoplastic Agents; D053778:Thiazolidines; D000677:Amsacrine; D004247:DNA