title: Long-term outcomes of vitrectomy for progressive X-linked retinoschisis.
abstract: OBJECTIVE
  To evaluate the long-term outcomes of vitrectomy for progressive X-linked retinoschisis.
  
  
  METHODS
  Prospective, nonrandomized, consecutive, interventional case series.
  
  
  METHODS
  Twenty-eight eyes of 22 patients who were diagnosed with progressive X-linked retinoschisis were divided into 2 groups: a nonsurgical group (n = 11) and a vitrectomy group (n = 17). The main outcome measures included best-corrected visual acuity, the area of the macular schisis cavity measured by optical coherence tomography, the retinal anatomic status, and complications.
  
  
  RESULTS
  The mean follow-up period was 34.7 months (range, 10 to 68 months). The mean best-corrected visual acuity increased from 20/125 at baseline to 20/55 at the final follow-up in the vitrectomy group (P = .001), but decreased from 20/100 at baseline to 20/400 at the final follow-up in the nonsurgical group (P = .000). In the vitrectomy group, the macular schisis cavity resolved in all 17 eyes; the mean area of the macular schisis cavity decreased from 0.85 mm(2) at baseline to 0.23 mm(2) at the final follow-up (P = .000), and the retinas of 16 eyes (94%) were attached after surgery. In the nonsurgical group, retinal schisis progressively extended in 9 eyes (82%); the mean area of the macular schisis cavity increased from 0.82 mm(2) at baseline to 1.21 mm(2) at the final follow-up (P = .000); in 8 eyes (72%), retinal detachment developed, and 2 eyes (18%) experienced vitreous hemorrhage, which terminated the observations.
  
  
  CONCLUSIONS
  Vitrectomy may be an effective and essential treatment for patients with progressive X-linked retinoschisis to prevent a deterioration of vision before severe complications developed in their eyes.
authors.affiliation: State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China.
authors.forename: Honghua
authors.initials: H
authors.lastname: Yu
authors.forename: Tao
authors.initials: T
authors.lastname: Li
authors.forename: Yan
authors.initials: Y
authors.lastname: Luo
authors.forename: Shanshan
authors.initials: S
authors.lastname: Yu
authors.forename: Shiqing
authors.initials: S
authors.lastname: Li
authors.forename: Lei
authors.initials: L
authors.lastname: Lei
authors.forename: Jiaqing
authors.initials: J
authors.lastname: Li
authors.forename: Xiaoyan
authors.initials: X
authors.lastname: Ding
authors.forename: Ling
authors.initials: L
authors.lastname: Yuan
authors.forename: Shibo
authors.initials: S
authors.lastname: Tang
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D018450:Disease Progression; D004596:Electroretinography; D005451:Fluorescein Angiography; D005500:Follow-Up Studies; D006801:Humans; D011446:Prospective Studies; D041441:Retinoschisis / Q000503:physiopathology / Q000601:surgery*; D041623:Tomography, Optical Coherence; D016896:Treatment Outcome; D014792:Visual Acuity / Q000502:physiology; D014821:Vitrectomy