title: Serum levels of copper, selenium and manganese in forestry workers testing IgG positive for Brucella, Borrelia, and Rickettsia.
abstract: The aim of this study is to measure the alterations in the trace levels of serum copper (Cu), selenium (Se), and manganese (Mn) in forestry workers testing immunoglobulin G (IgG)-positive for Brucella, Borrelia, and Rickettsia. The study was conducted on a sample of 758 subjects (560 male and 198 female). All the subjects underwent medical examinations, which investigated particularly the presence of clinical signs compatible with zoonoses, and routine blood tests from venous blood sample, which tested previous immunisation versus cited microorganisms and serum concentration of Cu, Se, and Mn. The subjects were divided according to IgG positivity versus the cited microorganisms. The group of subjects with IgG positive versus Brucella showed statistically significant higher Cu levels than controls, while the Mn levels were not; the group of subjects with IgG positive versus Rickettsia showed higher levels of all three tested metals. The concentration of the examined metals did not show statistically significant difference between IgG-positive subjects versus subjects with Borrelia compared to controls. These data could confirm the role of both Cu and Se  in the regulation of immune response.
authors.affiliation: Dipartimento di Medicina Sociale del Territorio, Sezione Medicina del Lavoro, Università degli Studi di Messina, Messina, Italy.
authors.forename: Simona
authors.initials: S
authors.lastname: Abbate
authors.forename: Concetto
authors.initials: C
authors.lastname: Giorgianni
authors.forename: Graziella
authors.initials: G
authors.lastname: D'Arrigo
authors.forename: Renato
authors.initials: R
authors.lastname: Brecciaroli
authors.forename: Rosaria
authors.initials: R
authors.lastname: Catanoso
authors.forename: Carmela
authors.initials: C
authors.lastname: Alibrando
authors.forename: Giovanna
authors.initials: G
authors.lastname: Spatari
authors.forename: Silvia
authors.initials: S
authors.lastname: Gangemi
authors.forename: Carmelo
authors.initials: C
authors.lastname: Abbate
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood*; D001898:Borrelia / Q000276:immunology / Q000302:isolation & purification; D002002:Brucella / Q000276:immunology / Q000302:isolation & purification; D003300:Copper / Q000097:blood*; D005260:Female; D016468:Forestry; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008297:Male; D008345:Manganese / Q000097:blood*; D008875:Middle Aged; D012281:Rickettsia / Q000276:immunology / Q000302:isolation & purification; D012643:Selenium / Q000097:blood*
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D008345:Manganese; D003300:Copper; D012643:Selenium