title: Precision of GE Lunar iDXA for the measurement of total and regional body composition in nonobese adults.
abstract: Dual-energy X-ray absorptiometry (DXA) is a well-accepted technique for measuring body composition. Knowledge of measurement precision is critical for monitoring of changes in bone mineral content (BMC), and fat and lean masses. The purpose of this study was to characterize in vivo precision of total body and regional body composition parameters using the GE Lunar iDXA (GE Healthcare Lunar, Madison, WI) system in a sample of nonobese subjects. We also evaluated the difference between expert and automatic region-of-interest (ROI) analysis on body composition precision. To this end, 2 total body scans were performed on each subject with repositioning between scans. Total body precision for BMC, fat and lean mass were 0.5%, 1.0%, and 0.5% coefficient of variation (CV), respectively. Regional body composition precision error was less than 2.5% CV for all regions except arms. Precision error was higher for the arms (CV: BMC 1.5%; fat mass 2.8%; lean mass 1.6%), likely owing to the placement of arms relative to torso leading to differences in ROI. There was a significant correlation between auto ROI and expert ROI (r>0.99). Small, but statistically significant differences were found between auto and manual ROI. Differences were small in total body, leg, trunk, and android and gynoid regions (0.004-2.8%), but larger in arm region (3.0-6.3%). Total body and regional precision for iDXA are small and it is suggested that iDXA may be useful for monitoring changes in body composition during longitudinal trials.
authors.affiliation: Computational Biology and Biostatistics Laboratory, GE Global Research Center, Niskayuna, NY, USA. Electronic address: rothney@ge.com.
authors.forename: Megan P
authors.initials: MP
authors.lastname: Rothney
authors.affiliation: Nestec Ltd., Nestle Research Center, Lausanne, Switzerland.
authors.forename: Francois-Pierre
authors.initials: FP
authors.lastname: Martin
authors.affiliation: GE Healthcare, Madison, WI, USA.
authors.forename: Yi
authors.initials: Y
authors.lastname: Xia
authors.affiliation: Nestec Ltd., Nestle Research Center, Lausanne, Switzerland.
authors.forename: Maurice
authors.initials: M
authors.lastname: Beaumont
authors.affiliation: Computational Biology and Biostatistics Laboratory, GE Global Research Center, Niskayuna, NY, USA.
authors.forename: Cynthia
authors.initials: C
authors.lastname: Davis
authors.affiliation: GE Healthcare, Madison, WI, USA.
authors.forename: David
authors.initials: D
authors.lastname: Ergun
authors.affiliation: Nestec Ltd., Nestle Research Center, Lausanne, Switzerland.
authors.forename: Laurent
authors.initials: L
authors.lastname: Fay
authors.affiliation: Computational Biology and Biostatistics Laboratory, GE Global Research Center, Niskayuna, NY, USA.
authors.forename: Fiona
authors.initials: F
authors.lastname: Ginty
authors.affiliation: Nestec Ltd., Nestle Research Center, Lausanne, Switzerland.
authors.forename: Sunil
authors.initials: S
authors.lastname: Kochhar
authors.affiliation: GE Healthcare, Madison, WI, USA.
authors.forename: Wynn
authors.initials: W
authors.lastname: Wacker
authors.affiliation: Nestec Ltd., Nestle Research Center, Lausanne, Switzerland.
authors.forename: Serge
authors.initials: S
authors.lastname: Rezzi
mesh_terms: D015502:Absorptiometry, Photon / Q000295:instrumentation*; D000328:Adult; D001823:Body Composition / Q000502:physiology*; D015519:Bone Density; D004867:Equipment Design; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009765:Obesity; D015203:Reproducibility of Results; D055815:Young Adult