title: NADPH oxidase regulates efficacy of vaccination in aspergillosis.
abstract: Invasive aspergillosis is often a consequence of immune suppression, and accumulating evidence points to a role for adaptive immunity. Hence, it may be possible to manipulate the adaptive immune system to enhance protective immunity in at-risk individuals. In this issue of the JCI, De Luca and colleagues describe the ontogeny of adaptive immune responses to murine aspergillosis infection in relation to vaccination. Their thought-provoking findings reveal the complexities of vaccine-induced immunity and could be used to improve vaccine efficacy.
authors.affiliation: Division of Infectious Diseases, University of Cincinnati College of Medicine, and the Veterans Affairs Hospital, Cincinnati, Ohio 45267-0560, USA. george.deepe@uc.edu
authors.forename: George S
authors.initials: GS
authors.lastname: Deepe
mesh_terms: D000818:Animals; D000946:Antigens, Fungal / Q000276:immunology*; D045142:Cross-Priming; D005260:Female; D006105:Granulomatous Disease, Chronic / Q000276:immunology*; D014611:Vaccination
chemical_list: D000946:Antigens, Fungal