title: Paraoxonase 1 polymorphisms L55M and Q192R were not risk factors for Parkinson's disease: a HuGE review and meta-analysis.
abstract: OBJECTIVE
  The Paraoxonase 1 (PON1) has been studied as a potential candidate gene for Parkinson's disease risk, but direct evidence from genetic association studies remains inconclusive. We performed a meta-analysis pooling data from all relevant studies in order to determine the effects of two PON 1 polymorphisms (L55M and Q192R) on Parkinson's disease.
  
  
  METHODS
  We applied a random effects to combine odds ratio (OR) and 95% confidence intervals. Q statistic was used to evaluate the homogeneity, and Egger's test and Funnel plot were used to assess publication bias. In secondary analyses, we examined dominant and recessive models as well.
  
  
  RESULTS
  Concerning the PON1 L55M polymorphism, we identified 9 eligible studies (a total of 2582 cases and 3997 controls). The random effects pooled OR was OR=1.29, (0.90, 1.84). Concerning the Q192R polymorphism, we identified 7 eligible studies (a total of 2582 cases and 3997 controls). The random effects pooled OR was OR=1.08(0.81, 1.43). Analysis with dominant and recessive genetic models yielded the same inferences as genotype-based comparisons for both of the two polymorphisms.
  
  
  CONCLUSIONS
  The results of this meta-analysis suggested that both PON1 L55M and Q192R were not responsible for PD.
authors.affiliation: Department of Epidemiology and Statistics, School of Public Health, Hebei Medical University, 361 East Zhongshan Road, Shijiazhuang 050017, China.
authors.forename: Ying-Li
authors.initials: YL
authors.lastname: Liu
authors.forename: Jie
authors.initials: J
authors.lastname: Yang
authors.forename: Jie
authors.initials: J
authors.lastname: Zheng
authors.forename: Dian-Wu
authors.initials: DW
authors.lastname: Liu
authors.forename: Tian
authors.initials: T
authors.lastname: Liu
authors.forename: Jian-Min
authors.initials: JM
authors.lastname: Wang
authors.forename: Chao-Nan
authors.initials: CN
authors.lastname: Wang
authors.forename: Ming-Wei
authors.initials: MW
authors.lastname: Wang
authors.forename: Qing-Bao
authors.initials: QB
authors.lastname: Tian
mesh_terms: D043303:Aryldialkylphosphatase / Q000235:genetics*; D044466:Asian People / Q000235:genetics / Q000706:statistics & numerical data; D005260:Female; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D008297:Male; D008957:Models, Genetic; D010300:Parkinson Disease / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors; D044465:White People / Q000235:genetics / Q000706:statistics & numerical data
chemical_list: D043303:Aryldialkylphosphatase; C468406:PON1 protein, human