title: Surfactant protein a polymorphism is associated with susceptibility to chronic obstructive pulmonary disease in Chinese Uighur population.
abstract: This study investigated the correlation between surfactant protein-A (SP-A) polymorphism and the susceptibility of chronic obstructive pulmonary disease (COPD) in Xinjiang Uighurs. Genomic DNA was extracted from peripheral blood of 194 COPD smokers and 201 healthy smokers of Uighur who were hospitalized in or paid a visit to one of the four Xinjiang-based hospitals involved in the study, from March 2009 to December 2010. Single nucleotide polymorphisms (SNPs) were studied at aa62 (CCA/CCG rs1136451) and aa219 (CGG/TGG, rs4253527) in SP-A. Genotypes were determined by using the TaqMan polymerase chain reaction (PCR). Our results showed that genotype frequencies were different between the COPD and normal smokers in aa62 (x                         (2)=6.852, P=0.033). There were also significant differences in allele genotype frequencies between the COPD and the control and allele G might decrease the risk COPD (x                         (2)=6.545, P=0.011; OR=0.663; 95% CI: 0.484-0.909). The result suggested that polymorphism of aa62 (CCA/CCG, rs1136451) of SP-A may be associated with the susceptibility to COPD in Xinjiang Uighurs.
authors.affiliation: Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.|Department of Respiratory Medicine, the First Affiliated Hospital of the Medical College, Shihezi University, Shihezi, 832000, China.
authors.forename: Jian
authors.initials: J
authors.lastname: Guan
authors.affiliation: Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
authors.forename: Xiansheng
authors.initials: X
authors.lastname: Liu
authors.affiliation: Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
authors.forename: Jungang
authors.initials: J
authors.lastname: Xie
authors.affiliation: Department of Respiratory Medicine, the First Affiliated Hospital of the Medical College, Shihezi University, Shihezi, 832000, China.
authors.forename: Xilin
authors.initials: X
authors.lastname: Xu
authors.affiliation: Department of Respiratory Medicine, the First Affiliated Hospital of the Medical College, Shihezi University, Shihezi, 832000, China.
authors.forename: Shuxin
authors.initials: S
authors.lastname: Luo
authors.affiliation: Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China.
authors.forename: Ran
authors.initials: R
authors.lastname: Wang
authors.affiliation: Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. yjxu@tjh.tjmu.edu.cn.
authors.forename: Yongjian
authors.initials: Y
authors.lastname: Xu
mesh_terms: D002681:China / Q000453:epidemiology; D005819:Genetic Markers / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000208:ethnology* / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D015995:Prevalence; D029424:Pulmonary Disease, Chronic Obstructive / Q000208:ethnology* / Q000235:genetics*; D037662:Pulmonary Surfactant-Associated Protein A / Q000235:genetics*; D012307:Risk Factors
chemical_list: D005819:Genetic Markers; D037662:Pulmonary Surfactant-Associated Protein A