title: [Function of SM protein in vesicle transport].
abstract: Most cells contain various transport vesicles that target to different destinations. The underlying molecular mechanisms are highly conserved in evolution. Sec1/Munc-18 (SM) proteins play an important role on regulating vesicle transport by interacting with soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) at each vesicle fusion sites. SM proteins interact with syntaxin, an important component in SNARE complex, to regulate the assembly of SNARE complex, and promote overall membrane fusion process together with SNARE complex. This review summaries new research progresses of structure and function of SM protein.
authors.affiliation: Key Laboratory of Saline-alkali Vegetation Ecology Restoration in Oil Field of Ministry of Education, Alkali Soil Natural Environmental Science Center, Northeast Forestry University, Harbin 150040, China. feixiang1209@163.com
authors.forename: Xiang
authors.initials: X
authors.lastname: Zhao
authors.forename: Bao-Da
authors.initials: BD
authors.lastname: Han
authors.forename: Li-Xin
authors.initials: LX
authors.lastname: Li
mesh_terms: D000818:Animals; D001692:Biological Transport; D002135:Calcium-Binding Proteins / Q000502:physiology; D022162:Cytoplasmic Vesicles / Q000378:metabolism*; D006801:Humans; D051938:Munc18 Proteins / Q000737:chemistry / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000502:physiology; D050683:R-SNARE Proteins / Q000502:physiology; D050600:SNARE Proteins / Q000502:physiology
chemical_list: D002135:Calcium-Binding Proteins; C091524:DOC2A protein, human; D051938:Munc18 Proteins; D009419:Nerve Tissue Proteins; D050683:R-SNARE Proteins; D050600:SNARE Proteins; C484767:STXBP5 protein, human