title: Role of cathepsin A and cathepsin C in the regulation of glycosidase activity.
abstract: Increased tissue activity of cathepsin A and cathepsin C can be observed in many pathological conditions. It is associated with an enhanced degradation of glycosaminoglycans, proteoglycans, and glycoproteins, and results in their decreased tissue content. Cathepsin C releases the glycosidases from complexes formed with cathepsin A, and reinstates their activity. In this review a current state of knowledge is presented concerning the regulation of selected glycosidases activity by cathepsin A (EC 3.4.16.1) and C (EC 3.4.14.1).
authors.affiliation: Department of Lung Diseases and Tuberculosis, Medical University of Bialystok, Poland.
authors.forename: Alina
authors.initials: A
authors.lastname: Minarowska
authors.forename: Łukasz
authors.initials: Ł
authors.lastname: Minarowski
authors.forename: Alicja
authors.initials: A
authors.lastname: Karwowska
authors.forename: Anna Justyna
authors.initials: AJ
authors.lastname: Milewska
authors.forename: Marek
authors.initials: M
authors.lastname: Gacko
mesh_terms: D000595:Amino Acid Sequence; D043402:Cathepsin A / Q000378:metabolism*; D020789:Cathepsin C / Q000378:metabolism*; D006026:Glycoside Hydrolases / Q000378:metabolism*; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data
chemical_list: D006026:Glycoside Hydrolases; D020789:Cathepsin C; D043402:Cathepsin A