title: Nonketotic hyperosmolar syndrome as an acute complication of type 1 diabetes onset in a 20-month-old boy with congenital central nervous system defect.
abstract: Hyperglycemic hyperosmolar syndrome (HHS) is one of the most severe acute complications of type 2 diabetes, but may also be developed in type 1 diabetes. Similar to ketoacidosis,HHS still remains one of the major causes of morbidity and mortality in patients with diabetes,despite a significant progress in understanding its pathogenesis and greater consensus on HHS diagnosis and treatment. It is mainly observed in elderly patients with type 2 diabetes. However,it may also occur in children,especially in infants and those with concomitant central nervous system (CNS) defects or suffering from severe infections associated with dehydration. The authors report a case of HHS in a 20-month-old child with central nervous system abnormality. Symptoms observed in our patient are characteristic for HHS. It must be emphasized that HHS may accompany diabetes onset also in children.
authors.affiliation: Department of Pediatrics, Pediatric Endocrinology and Diabetes, Jan Paweł II Upper Silesian Center of Child's Health, Katowice, Poland. mchumiecki@gmail.com
authors.forename: Miron
authors.initials: M
authors.lastname: Chumiecki
authors.forename: Mariola
authors.initials: M
authors.lastname: Minkina-Pedras
authors.forename: Agata
authors.initials: A
authors.lastname: Chobot
authors.forename: Przemysława
authors.initials: P
authors.lastname: Jarosz-Chobot
mesh_terms: D002490:Central Nervous System / Q000002:abnormalities*; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000150:complications / Q000175:diagnosis*; D016883:Diabetic Ketoacidosis / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D020158:Hyperglycinemia, Nonketotic / Q000150:complications / Q000175:diagnosis*; D008297:Male; D013577:Syndrome