title: Evaluation of antinociceptive and anti-inflammatory activity of hydromethanol extract of Cocos nucifera L.
abstract: Cocos nucifera L. (family: arecaceae) is generally straight unbranched plant, traditionally cultivated for its fruit (coconut) in home gardens. In the present study, anti-inflammatory and antinociceptive (analgesic) activity of hydromethanol extract of Cocos nucifera L. (HECN) was evaluated in animal models. HECN showed significant (p < 0.05) and dosedependent anti-inflammatory activity in carrageenan induced paw oedema models of inflammation and the result was comparable with the standard drug diclofenac. In addition, the extract also showed highly significant (p < 0.01) antinociceptive activity. HECN treated group showed increase in the reaction time in hot plate method and decrease the writhing induced by acetic acid in mice when compared with control group animal. The anti-inflammatory and antinociceptive activity observed in the present study could be attributed largely to the presence of its antioxidant phytoconstituents such as flavonoid, saponin and polyphenols.
authors.affiliation: Department of Pharmaceutical Technology, Jadavpur University, Kolkata, 700032, India. sagar_n2007@yahoo.co.in
authors.forename: Sagar
authors.initials: S
authors.lastname: Naskar
authors.forename: U K
authors.initials: UK
authors.lastname: Mazumder
authors.forename: G
authors.initials: G
authors.lastname: Pramanik
authors.forename: P
authors.initials: P
authors.lastname: Saha
authors.forename: P K
authors.initials: PK
authors.lastname: Haldar
authors.forename: M
authors.initials: M
authors.lastname: Gupta
mesh_terms: D000700:Analgesics / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D000975:Antioxidants / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology; D003059:Cocos / Q000737:chemistry*; D004008:Diclofenac / Q000494:pharmacology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D007249:Inflammation / Q000188:drug therapy; D008297:Male; D051379:Mice; D010146:Pain / Q000188:drug therapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D010936:Plant Extracts; D004008:Diclofenac