title: Acute ghrelin administration reverses depressive-like behavior induced by bilateral olfactory bulbectomy in mice.
abstract: This study aims to examine the antidepressant-like action of Ghrelin (Ghr), a hormone synthesized predominantly by gastrointestinal endocrine cells and released during periods of negative energy balance, in two behavioral models: tail suspension test (TST), a predictive model of antidepressant activity, and the olfactory bulbectomy (OB), an established animal model of depression. The reduction in the immobility time in the TST was the parameter used to assess antidepressant-like effect of Ghr. The depressive-like behavior in olfactory bulbectomized mice was inferred through the increase in the immobility time in the TST and the hyperlocomotor activity in the open-field test. Ghr produced antidepressant-like effect in TST (0.3 nmol/μl, i.c.v.), and reversed OB-induced depressive-like behavior. In conclusion, these results provide clear evidence that an acute administration of ghrelin produce antidepressant-like effect in the TST and OB.
authors.affiliation: Cátedra de Fisiología, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina. vcarlini@live.com.ar
authors.forename: Valeria Paola
authors.initials: VP
authors.lastname: Carlini
authors.forename: Daniele Guilhermano
authors.initials: DG
authors.lastname: Machado
authors.forename: Florencia
authors.initials: F
authors.lastname: Buteler
authors.forename: Marisa
authors.initials: M
authors.lastname: Ghersi
authors.forename: Marina F
authors.initials: MF
authors.lastname: Ponzio
authors.forename: Ana Carolina
authors.initials: AC
authors.lastname: Martini
authors.forename: Helgi B
authors.initials: HB
authors.lastname: Schiöth
authors.forename: Marta Fiol
authors.initials: MF
authors.lastname: de Cuneo
authors.forename: Ana Lúcia S
authors.initials: AL
authors.lastname: Rodrigues
authors.forename: Susana R
authors.initials: SR
authors.lastname: de Barioglio
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects*; D003863:Depression / Q000188:drug therapy*; D005260:Female; D054439:Ghrelin / Q000008:administration & dosage* / Q000494:pharmacology; D019417:Hindlimb Suspension; D046353:Immobility Response, Tonic / Q000187:drug effects; D051379:Mice; D009830:Olfactory Bulb / Q000187:drug effects / Q000601:surgery
chemical_list: D000928:Antidepressive Agents; D054439:Ghrelin