title: Effects of curcumin and Ginkgo biloba on matrix metalloproteinases gene expression and other biomarkers of inflammatory bowel disease.
abstract: Treatment of inflammatory bowel disease (IBD) by synthetic active ingredients leads to many side effects. The objective of this study was to manage IBD using natural products as curcumin and Ginkgo biloba. Rats were divided into four groups (control, IBD, curcumin treated, and ginkgo treated). Inflammation was assessed by determination of myeloperoxidase, matrix metalloproteinases, metalloproteinase-1 inhibitor, nitric oxide, hydroxyproline, tumor necrosis factor-alpha, ceruloplasmin, and histopathological scoring. IBD induction significantly increased all measured parameters. Treated groups had significantly lower levels when compared with the IBD group. In conclusion, curcumin and ginkgo were effective in prevention and treatment of IBD.
authors.affiliation: Faculty of Pharmacy, Cairo University, Cairo, Egypt.
authors.forename: Tarek Kamal
authors.initials: TK
authors.lastname: Motawi
authors.forename: Sherine Maher
authors.initials: SM
authors.lastname: Rizk
authors.forename: Ahmed Hassan
authors.initials: AH
authors.lastname: Shehata
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000097:blood / Q000378:metabolism; D002570:Ceruloplasmin / Q000378:metabolism; D003106:Colon / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D003474:Curcumin / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D015870:Gene Expression / Q000187:drug effects; D020441:Ginkgo biloba / Q000737:chemistry*; D006909:Hydroxyproline / Q000378:metabolism; D015212:Inflammatory Bowel Diseases / Q000097:blood / Q000139:chemically induced / Q000201:enzymology*; D008297:Male; D020781:Matrix Metalloproteinase 1 / Q000235:genetics / Q000378:metabolism*; D019278:Matrix Metalloproteinase 3 / Q000235:genetics / Q000378:metabolism*; D009569:Nitric Oxide / Q000097:blood; D009195:Peroxidase / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D019715:Tissue Inhibitor of Metalloproteinase-1 / Q000235:genetics / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000097:blood
chemical_list: D015415:Biomarkers; D004365:Drugs, Chinese Herbal; C576839:TIMP1 protein, rat; D019715:Tissue Inhibitor of Metalloproteinase-1; D014409:Tumor Necrosis Factor-alpha; D009569:Nitric Oxide; D009195:Peroxidase; D002570:Ceruloplasmin; D019278:Matrix Metalloproteinase 3; C576840:MMP1 protein, rat; D020781:Matrix Metalloproteinase 1; D003474:Curcumin; D006909:Hydroxyproline