title: Reduced plasma nonesterified fatty acid levels and the advent of an acute lung injury in mice after intravenous or enteral oleic acid administration.
abstract: Although exerting valuable functions in living organisms, nonesterified fatty acids (NEFAs) can be toxic to cells. Increased blood concentration of oleic acid (OLA) and other fatty acids is detected in many pathological conditions. In sepsis and leptospirosis, high plasma levels of NEFA and low albumin concentrations are correlated to the disease severity. Surprisingly, 24 h after intravenous or intragastric administration of OLA, main NEFA levels (OLA inclusive) were dose dependently decreased. However, lung injury was detected in intravenously treated mice, and highest dose killed all mice. When administered by the enteral route, OLA was not toxic in any tested conditions. Results indicate that OLA has important regulatory properties on fatty acid metabolism, possibly lowering circulating fatty acid through activation of peroxisome proliferator-activated receptors. The significant reduction in blood NEFA levels detected after OLA enteral administration can contribute to the already known health benefits brought about by unsaturated-fatty-acid-enriched diets.
authors.affiliation: Laboratório de Imunofarmacologia, Fundação Oswaldo Cruz, FIOCRUZ, Rio de Janeiro 21040-900, Brazil. cassianofg@gmail.com
authors.forename: Cassiano Felippe
authors.initials: CF
authors.lastname: Gonçalves de Albuquerque
authors.forename: Patrícia
authors.initials: P
authors.lastname: Burth
authors.forename: Mauricio
authors.initials: M
authors.lastname: Younes Ibrahim
authors.forename: Diogo Gomes
authors.initials: DG
authors.lastname: Garcia
authors.forename: Patrícia Torres
authors.initials: PT
authors.lastname: Bozza
authors.forename: Hugo Caire
authors.initials: HC
authors.lastname: Castro Faria Neto
authors.forename: Mauro Velho
authors.initials: MV
authors.lastname: Castro Faria
mesh_terms: D055371:Acute Lung Injury / Q000378:metabolism*; D000418:Albumins / Q000378:metabolism; D000818:Animals; D001992:Bronchoalveolar Lavage Fluid; D015232:Dinoprostone / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005227:Fatty Acids / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000008:administration & dosage* / Q000378:metabolism*; D005231:Fatty Acids, Unsaturated / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism; D007262:Infusions, Intravenous; D007975:Leukotriene B4 / Q000378:metabolism; D008055:Lipids / Q000737:chemistry; D008297:Male; D051379:Mice; D019301:Oleic Acid / Q000008:administration & dosage* / Q000378:metabolism; D047492:Peroxisome Proliferator-Activated Receptors / Q000378:metabolism
chemical_list: D000418:Albumins; D005227:Fatty Acids; D005230:Fatty Acids, Nonesterified; D005231:Fatty Acids, Unsaturated; D008055:Lipids; D047492:Peroxisome Proliferator-Activated Receptors; D007975:Leukotriene B4; D019301:Oleic Acid; D015232:Dinoprostone