title: In vitro assessment of poly(methylmethacrylate)-based bone cement containing magnetite nanoparticles for hyperthermia treatment of bone tumor.
abstract: Poly(methylmethacrylate) (PMMA)-based cements containing magnetite (C-PMMA/Fe(3)O(4)) is useful in hyperthermia treatment for bone tumor. We have prepared C-PMMA/Fe(3)O(4) by incorporating Fe(3) O(4) powders of different diameters (means of 300, 35, and 11 nm) into the polymerization reaction of methyl methacrylate monomer to develop a new bone cement with high heating efficiencies in alternating current (AC) magnetic fields. Further, we have investigated the in vitro heating capability of the cements in different AC magnetic fields. The mechanical strength and biocompatibility of the resultant cements were also assessed. Their heat generation strongly depends on the magnetite nanoparticle sizes and applied magnetic fields. The cement containing Fe(3)O(4) with mean diameter around 35 nm exhibited the highest heating capability in AC magnetic fields of 120 and 300 Oe at 100 kHz while that with mean diameter around 11 nm exhibited optimum heating capability in AC magnetic fields of 40 Oe at 600 kHz. The incorporation of Fe(3)O(4) into cement-30 wt % of the total amount of cement-did not significantly change the compressive strength of cement, and the proliferation of rat fibroblast Rat-1 cells on cement discs was not inhibited. Our investigations are useful for designing new PMMA/Fe(3)O(4) bone cement with high heating efficiencies and biocompatibilities for bone tumor treatments.
authors.affiliation: College of Chemistry and Chemical Engineering, Guangxi University, Nanning 530004, China. zhixiali@hotmail.com
authors.forename: Zhixia
authors.initials: Z
authors.lastname: Li
authors.forename: Koki
authors.initials: K
authors.lastname: Kawamura
authors.forename: Masakazu
authors.initials: M
authors.lastname: Kawashita
authors.forename: Tada-aki
authors.initials: TA
authors.lastname: Kudo
authors.forename: Hiroyasu
authors.initials: H
authors.lastname: Kanetaka
authors.forename: Masahiro
authors.initials: M
authors.lastname: Hiraoka
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology; D001843:Bone Cements / Q000494:pharmacology*; D001859:Bone Neoplasms / Q000628:therapy*; D004247:DNA / Q000378:metabolism; D004560:Electricity; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D006358:Hot Temperature; D006979:Hyperthermia, Induced; D060526:Magnetic Fields; D058185:Magnetite Nanoparticles / Q000627:therapeutic use* / Q000648:ultrastructure; D008422:Materials Testing; D055595:Mechanical Phenomena / Q000187:drug effects; D019904:Polymethyl Methacrylate / Q000494:pharmacology*; D051381:Rats; D014961:X-Ray Diffraction
chemical_list: D001672:Biocompatible Materials; D001843:Bone Cements; D058185:Magnetite Nanoparticles; D004247:DNA; D019904:Polymethyl Methacrylate