title: Outcomes of endodontic therapy in general practice: a study by the Practitioners Engaged in Applied Research and Learning Network.
abstract: BACKGROUND
  The authors undertook a study involving members of a dental practice-based research network to determine the outcome and factors associated with success and failure of endodontic therapy.
  
  
  METHODS
  Members in participating practices (practitioner-investigators [P-Is]) invited the enrollment of all patients seeking treatment in the practice who had undergone primary endodontic therapy and restoration in a permanent tooth three to five years previously. If a patient had more than one tooth so treated, the P-I selected as the index tooth the tooth treated earliest during the three- to five-year period. The authors excluded from the study any teeth that served as abutments for removable partial dentures or overdentures, third molars and teeth undergoing active orthodontic endodontic therapy. The primary outcome was retention of the index tooth. Secondary outcomes, in addition to extraction, that defined failure included clinical or radiographic evidence (or both) of periapical pathosis, endodontic retreatment or pain on percussion.
  
  
  RESULTS
  P-Is in 64 network practices enrolled 1,312 patients with a mean (standard deviation) time to follow-up of 3.9 (0.6) years. During that period, 3.3 percent of the index teeth were extracted, 2.2 percent underwent retreatment, 3.6 percent had pain on percussion and 10.6 percent had periapical radiolucencies for a combined failure rate of 19.1 percent. The presence of preoperative periapical radiolucency with a diagnosis of either irreversible pulpitis or necrotic pulp was associated with failure after multivariate analysis, as were multiple canals, male sex and Hispanic/Latino ethnicity.
  
  
  CONCLUSIONS
  These results suggest that failure rates for endodontic therapy are higher than previously reported in general practices, according to results of studies based on dental insurance claims data.
  
  
  CONCLUSIONS
  The results of this study can help guide the practitioner in deciding the most appropriate course of therapy for teeth with irreversible pulpitis, necrotic pulp or periapical periodontitis.
authors.affiliation: Practitioners Engaged in Applied Research and Learning (PEARL) Network, New York City, New York, USA.
authors.forename: Susan D
authors.initials: SD
authors.lastname: Bernstein
authors.forename: Allan J
authors.initials: AJ
authors.lastname: Horowitz
authors.forename: Martin
authors.initials: M
authors.lastname: Man
authors.forename: Hongyu
authors.initials: H
authors.lastname: Wu
authors.forename: Denise
authors.initials: D
authors.lastname: Foran
authors.forename: Donald A
authors.initials: DA
authors.lastname: Vena
authors.forename: Damon
authors.initials: D
authors.lastname: Collie
authors.forename: Abigail G
authors.initials: AG
authors.lastname: Matthews
authors.forename: Frederick A
authors.initials: FA
authors.lastname: Curro
authors.forename: Van P
authors.initials: VP
authors.lastname: Thompson
authors.forename: Ronald G
authors.initials: RG
authors.lastname: Craig
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D055812:Community-Based Participatory Research; D018865:Dental Research / Q000379:methods*; D019232:Dental Restoration Failure; D004498:Education, Dental, Continuing; D004708:Endodontics / Q000193:education*; D005260:Female; D005792:General Practice, Dental; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012107:Research Design; D019233:Retreatment; D012189:Retrospective Studies; D012390:Root Canal Therapy / Q000009:adverse effects*; D014081:Tooth Extraction; D014098:Toothache / Q000209:etiology; D016896:Treatment Outcome; D055815:Young Adult