title: Epidemiological, virological, and entomological characteristics of dengue from 1978 to 2009 in Guangzhou, China.
abstract: To understand its unprecedented resurgence, we examined the epidemiological, virological, and entomological features of dengue in Guangzhou during 1978-2009. Cases reported to the Guangzhou Centre for Disease Control and Prevention and data from virological and entomological surveillance were analyzed from three periods: 1978-1988, 1989-1999, and 2000-2009. Although cases decreased over time: 6,649 (1978-1988) to 6,479 (1989-1999) to 2,526 (2000-2009), geographical expansion resulted in districts with an average incidence >2.5/100,000, increasing from five (1978-1988, 1989-1999) to seven (2000-2009). Age distribution (mean age: 34.9 years) provided a trend of increasing dengue incidence among adults, and there was a significantly higher incidence among men with a sex ratio of 1.15:1 (P<0.001). Cases occurred from May through November with a peak between August and October, and a long-term trend was characterized by a three to five-year cyclical pattern. The most frequently isolated serotypes were DENV-2 (1978-1988) and DENV-1 (1989-1999 and 2000-2009). Seasonal fluctuations in immature densities of Aedes albopictus (sole transmission vector in Guangzhou) were consistent with the dengue seasonality. After a 30-year apparent absence, DENV-3 had reemerged in 2009. The current epidemiological situation is highly conducive to periodic dengue resurgences. Thus, a high degree of surveillance and strict control measures in source reduction should be maintained.
authors.affiliation: School of Public Health and Tropical Medicine of South Medical University, No.1838, North Road Avenue, Guangzhou, Guangdong Province 510515, PR China.
authors.forename: Lei
authors.initials: L
authors.lastname: Luo
authors.forename: Hui-ying
authors.initials: HY
authors.lastname: Liang
authors.forename: Yu-shan
authors.initials: YS
authors.lastname: Hu
authors.forename: Wei-jia
authors.initials: WJ
authors.lastname: Liu
authors.forename: Yu-lin
authors.initials: YL
authors.lastname: Wang
authors.forename: Qin-long
authors.initials: QL
authors.lastname: Jing
authors.forename: Xue-li
authors.initials: XL
authors.lastname: Zheng
authors.forename: Zhi-cong
authors.initials: ZC
authors.lastname: Yang
mesh_terms: D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000818:Animals; D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D009033:Culicidae / Q000502:physiology; D003715:Dengue / Q000453:epidemiology* / Q000635:transmission / Q000821:virology*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007303:Insect Vectors / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D012621:Seasons; D055815:Young Adult