title: Immunopotentiating properties of a multispecific α-anti-idiotype antibody.
abstract: Multispecificity is not a well-understood property of some antibodies. Different functions have been attributed to multispecific natural antibodies, commonly associated with the neutralization and clearance of antigens. Much less is known about the role of antibodies like these, based on their idiotypic connectivity. B7Y33 is a chimeric IgG1 version of a polyreactive α anti-idiotype antibody that is able to interact with different immunoglobulin and non-immunoglobulin antigens. Here we report the capacity of this antibody to enhance the immunogenicity of several autologous IgMs in adjuvant-free conditions. Our results suggest that the formation of immune complexes seems to be necessary, but not sufficient, to this activity. The potential involvement of the interaction of B7Y33 with the FcγRIIb is discussed.
authors.affiliation: Immunobiology Department, Center of Molecular Immunology, Havana, Cuba.
authors.forename: Tays
authors.initials: T
authors.lastname: Hernández
authors.forename: Cristina
authors.initials: C
authors.lastname: Mateo de Acosta
authors.forename: Rolando
authors.initials: R
authors.lastname: Pérez
mesh_terms: D000888:Antibodies, Anti-Idiotypic / Q000276:immunology / Q000627:therapeutic use*; D001324:Autoantigens / Q000276:immunology; D000939:Epitopes; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology / Q000627:therapeutic use*; D056747:Immunomodulation; D007167:Immunotherapy; D011485:Protein Binding; D017452:Receptors, IgG / Q000378:metabolism*; D011993:Recombinant Fusion Proteins / Q000276:immunology / Q000627:therapeutic use*
chemical_list: D000888:Antibodies, Anti-Idiotypic; D001324:Autoantigens; D000939:Epitopes; C080571:Fc gamma receptor IIB; D007074:Immunoglobulin G; D017452:Receptors, IgG; D011993:Recombinant Fusion Proteins