title: Vascular stiffness in incident peritoneal dialysis patients over time.
abstract: OBJECTIVE
  Vascular stiffness is prevalent in end-stage renal disease patients and predicts adverse events. This study describes the prevalence of vascular stiffness and its associated factors in a cohort of incident peritoneal dialysis (PD) patients.
  
  
  METHODS
  In a prospective observational study of 50 patients, carotid-femoral pulse wave velocity (PWV) were conducted at baseline, 3, 6 and 12 months after initiation of PD. Aortic calcification scores (ACS) were derived using plain lateral abdominal films. We examined the association of significant changes in PWV (defined as 1 m/s or 15% change from baseline) over 6 months in conjunction with demographic and clinical data.
  
  
  RESULTS
  The mean age was 58 years, 67% were male, and 48% were Caucasian. One third was diabetic, and 23% had pre-existing cardiovascular disease. Median eGFR was 8.7 ml/ min. ACS was strongly correlated with PWV (r = 0.62, p < 0.0001). Over 6 months, 42% demonstrated significant increases, while 23% demonstrated decreases in their PWV. Factors shown to be associated with increasing PWV were Caucasian race (OR = 4.50; CI: 0.97 - 20.83), higher phosphate (OR = 8.36; CI: 1.10 - 63.51) and a lower baseline PWV (OR = 0.67; CI: 0.45 - 0.99). Decrease in PWV was associated with the absence of calcium based phosphate binder usage (OR = 0.11; CI: 0.02 - 0.73). Changes in weight and PWV at 12 months were significantly correlated (p = 0.007, r = 0.57).
  
  
  CONCLUSIONS
  In this group of incident PD patients, we demonstrate a lower prevalence of vascular calcification than in hemodialysis patients, a correlation of calcification with PWV, and an important finding that PWV can change in either direction over a short period of time, which are associated with modifiable risk factors.
authors.affiliation: Division of Nephrology, University of British Columbia. mxtang@providencehealth.bc.ca
authors.forename: Mila
authors.initials: M
authors.lastname: Tang
authors.forename: Alexandra
authors.initials: A
authors.lastname: Romann
authors.forename: Giusy
authors.initials: G
authors.lastname: Chiarelli
authors.forename: Ognjenka
authors.initials: O
authors.lastname: Djurdjev
authors.forename: Monica
authors.initials: M
authors.lastname: Beaulieu
authors.forename: Mhairi
authors.initials: M
authors.lastname: Sigrist
authors.forename: Paul
authors.initials: P
authors.lastname: Taylor
authors.forename: Suneet
authors.initials: S
authors.lastname: Singh
authors.forename: Adeera
authors.initials: A
authors.lastname: Levin
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D011446:Prospective Studies; D011673:Pulsatile Flow; D061205:Vascular Calcification / Q000453:epidemiology / Q000209:etiology; D059289:Vascular Stiffness
chemical_list: D010281:Parathyroid Hormone