title: A new lignan with anti-tumour activity from Polygonum perfoliatum L.
abstract: The methanol extract of the tubers of Polygonum perfoliatum L. afforded a new lignan: 8-oxo-pinoresinol (1), and five known compounds 3',5-dihydroxy-3,4',5',7-tetramethoxy-flavone (2), catechin (3), quercetin (4), quercetin-3-O-β-D-glucuronide (5) and rutin (6). Their structures were established by MS, one- and two-dimensional NMR experiments. Compound 1 showed cytotoxicity against human mammary carcinoma (Bcap-37), human colon carcinoma (RKO), human hepatocellular carcinoma (SMMC-7721), human prostate carcinoma (PC3) and human erythroleukaemia (K562) cells.
authors.affiliation: School of Food Science and Biotechnology, Zhejiang Gongshang University, Hangzhou 310035, PR China. wkw220@yahoo.com.cn
authors.forename: Kui-Wu
authors.initials: KW
authors.lastname: Wang
authors.forename: Jun-Ru
authors.initials: JR
authors.lastname: Zhu
authors.forename: Lian-Qing
authors.initials: LQ
authors.lastname: Shen
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D047309:Flavones / Q000737:chemistry; D006801:Humans; D017705:Lignans / Q000737:chemistry* / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D028502:Polygonum / Q000737:chemistry*; D011794:Quercetin / Q000031:analogs & derivatives / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D047309:Flavones; D017705:Lignans; D010936:Plant Extracts; C443401:quercetin 3-O-glucuronide; D011794:Quercetin; C043562:flavone