title: Pharmacokinetics and correlation analysis of cilostazol in healthy Korean subjects.
abstract: BACKGROUND
  Cilostazol is frequently used to treat and prevent thrombosis in Korean patients.
  
  
  METHODS
  We performed the pharmacokinetic and correlation analysis of cilostazol in Korean healthy subjects. A total of male 78 volunteers was subjected to three separate bioequivalence studies in which 100 mg of cilostazol was administered. AUC, t(1/2), and C(max) were 12,100 ± 4,880 ng×h/ ml, 11.1 ± 4.4 hours, and 827 ± 361 ng/ml, respectively.
  
  
  RESULTS
  ALT was positively correlated with age and C(max) was positively correlated with AUC, but negatively correlated with body weight.
  
  
  CONCLUSIONS
  We suggest that the unique pharmacokinetic parameters and interrelationship can help to understand the pharmacokinetics of cilostazol in Korean subjects.
authors.affiliation: College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, South Korea.
authors.forename: Hye Duck
authors.initials: HD
authors.lastname: Choi
authors.forename: Hye Jung
authors.initials: HJ
authors.lastname: Lee
authors.forename: Sang Hun
authors.initials: SH
authors.lastname: Lee
authors.forename: Soo-Hwan
authors.initials: SH
authors.lastname: Kim
authors.forename: Chung Am
authors.initials: CA
authors.lastname: Choi
authors.forename: Min Jung
authors.initials: MJ
authors.lastname: Chang
authors.forename: Wan Gyoon
authors.initials: WG
authors.lastname: Shin
mesh_terms: D000328:Adult; D000367:Age Factors; D044466:Asian People; D001835:Body Weight; D000077407:Cilostazol; D018592:Cross-Over Studies; D006801:Humans; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000493:pharmacokinetics*; D013777:Tetrazoles / Q000493:pharmacokinetics*; D055815:Young Adult
chemical_list: D010975:Platelet Aggregation Inhibitors; D013777:Tetrazoles; D000077407:Cilostazol