title: Effect of dexamethasone on the frequency of postdural puncture headache after spinal anesthesia for cesarean section: a double-blind randomized clinical trial.
abstract: In this study, we evaluated the effect of dexamethasone used as a prophylaxis for nausea and vomiting on the incidence of postdural puncture headache (PDPH) in pregnant women receiving spinal anesthesia for cesarean section. In a prospective, randomized, double-blind, placebo-controlled study, 372 women under spinal anesthesia received 8 mg of dexamethasone or placebo intravenously just after the umbilical cord was clamped. The rate of PDPH and correlated risk factors were evaluated. The prevalence of nausea and vomiting in the dexamethasone and placebo groups was 54.4 and 51.7%, respectively. There was no statistically meaningful difference between the results (P value = 0.673). The overall incidence rate of PDPH was 10.8%, with 28 cases from the dexamethasone group compared with 11 subjects from the placebo group (P value = 0.006). This effect was most prominent on the first day (P value = 0.046) and disappeared on the second day after spinal anesthesia (P value = 0.678). Prophylactic treatment with 8 mg of dexamethasone not only increases the severity and incidence of PDPH, but is also ineffective in decreasing the prevalence of intra-operative nausea and vomiting during cesarean section. The treatment is a significant risk factor for the development of PDPH.
authors.affiliation: Department of Anesthesiology, Tehran University of Medical Sciences, Tehran, Iran. yousefshahi@tums.ac.ir
authors.forename: Fardin
authors.initials: F
authors.lastname: Yousefshahi
authors.forename: Alireza Rahat
authors.initials: AR
authors.lastname: Dahmardeh
authors.forename: Mohammadreza
authors.initials: M
authors.lastname: Khajavi
authors.forename: Atabak
authors.initials: A
authors.lastname: Najafi
authors.forename: Patricia
authors.initials: P
authors.lastname: Khashayar
authors.forename: Khosro
authors.initials: K
authors.lastname: Barkhordari
mesh_terms: D000328:Adult; D000775:Anesthesia, Spinal / Q000009:adverse effects*; D000932:Antiemetics / Q000627:therapeutic use*; D002585:Cesarean Section; D003907:Dexamethasone / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D009325:Nausea / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control*; D051299:Post-Dural Puncture Headache / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control*; D011247:Pregnancy; D016896:Treatment Outcome; D014839:Vomiting / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control*
chemical_list: D000932:Antiemetics; D003907:Dexamethasone