title: Severe hypercalcemia due to teriparatide.
abstract: Osteoporosis that is by far the most common metabolic bone disease, has been defined as a skeletal disorder characterized by compromised bone strength predisposing a person to an increased risk of fracture. Anabolic therapy with teriparatide, recombinant human parathyroid hormone (PTH 1-34), stimulates bone formation and resorption and improves trabecular and cortical microarchitecture. Teriparatide is indicated for the treatment of men and postmenopausal women with osteoporosis who are at high risk for fracture, including those who have failed or are intolerant of previous osteoporosis therapy. In conclusion, although teriparatide seems quite effective in the treatment of osteoporosis, it may cause life-threatening hypercalcemia. Therefore, patients should be closely monitored if symptoms of hypercalcemia are present during teriparatide treatment. Sustained hypercalcemia due to teriparatide treatment can not be seen in literature so we wanted to emphasize that severe hypercalcemia may develop due to teriperatide.
authors.affiliation: Internal Medicine Clinic, Bezmialem Vakif University Medical School Hospital, Istanbul, Turkey.
authors.forename: Cumali
authors.initials: C
authors.lastname: Karatoprak
authors.forename: Kadir
authors.initials: K
authors.lastname: Kayatas
authors.forename: Hanifi
authors.initials: H
authors.lastname: Kilicaslan
authors.forename: Servet
authors.initials: S
authors.lastname: Yolbas
authors.forename: Nurhan Aliye
authors.initials: NA
authors.lastname: Yazimci
authors.forename: Tolga
authors.initials: T
authors.lastname: Gümüskemer
authors.forename: Refik
authors.initials: R
authors.lastname: Demirtunç