title: [Role of intrarenal mononuclear cells apoptosis in the mechanisms of pathogenesis IgA-nephropathy in patients with different age groups].
abstract: Apoptosis plays an important role in the mechanism of regulation of the development of glomerulonephritis. We explored the role of apoptosis of mononuclear cells in patients with intrarenal IgA-nephropathy in different age groups and its relation to clinical laboratory, the morphological pattern of the disease. The position of the acceleration of the process of apoptosis intrarenal mononuclear cells in the elderly was confirmed. The effect of Fas antigen by intraglomerular mononuclear cells on systolic and diastolic blood pressure, regardless of the patient's age and its importance in the development of hypertrophy of arteries and arterioles of glomerulus and formation fuksinophilea deposits in the glomerulus were found. It is also shown that the infectious antigen (cytomegalovirus and Chlamydia trachomatis) differently affects the process of apoptosis of mononuclear cells.
authors.forename: I A
authors.initials: IA
authors.lastname: Rakitianskaia
authors.forename: T S
authors.initials: TS
authors.lastname: Riabova
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000942:Antigens, Bacterial / Q000378:metabolism; D000956:Antigens, Viral / Q000378:metabolism; D017209:Apoptosis / Q000276:immunology*; D051017:Apoptosis Regulatory Proteins / Q000378:metabolism; D001794:Blood Pressure / Q000276:immunology*; D002692:Chlamydia trachomatis / Q000276:immunology; D003587:Cytomegalovirus / Q000276:immunology; D005260:Female; D005922:Glomerulonephritis, IGA / Q000276:immunology / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D007677:Kidney Function Tests / Q000379:methods*; D007678:Kidney Glomerulus / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D007963:Leukocytes, Mononuclear / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D013223:Statistics as Topic; D019014:fas Receptor / Q000378:metabolism*
chemical_list: D000942:Antigens, Bacterial; D000956:Antigens, Viral; D051017:Apoptosis Regulatory Proteins; D019014:fas Receptor