title: [Fluorouracil implants for colorectal cancer: a systematic review and meta-analysis].
abstract: OBJECTIVE
  To evaluate the benefit and safety of fluorouracil implants on colorectal cancer.
  
  
  METHODS
  Based on the methods of Cochrane systematic reviews, databases including CBM(1982 to March 2011), CNKI(1911 to March 2011), EMBASE(1966 to March 2011), and Medline(1950 to March 2011) were searched to identify randomized controlled trials assessing the benefit of fluorouracil implants on colorectal cancer. The quality of the included studies was assessed using the Cochrane's tool for assessing bias. RevMan5.0 was used for meta-analysis.
  
  
  RESULTS
  Sixteen studies were included(n=1223). The quality of included studies was moderate. Fluorouracil implants could reduce the 2-year mortality(RR=0.33. 95% CI:0.18-0.59), 2-year metastasis rate(RR=0.35, 95% CI: 0.19-0.66), and 2-year recurrence rate(RR=0.48, 95% CI:0.36-0.65). There were no significant differences in complications and adverse effects between fluorouracil implants and the control group.
  
  
  CONCLUSIONS
  Current evidence demonstrates that fluorouracil implants may modestly improve the outcome of colorectal cancer patients without increasing its adverse events. However, the results should be interpreted with caution due to the risk of bias of included studies.
authors.affiliation: Department of Evidence-Based Medicine and Clinical Epidemiology, Sichuan University, Chengdu, China.
authors.forename: Yan
authors.initials: Y
authors.lastname: Huang
authors.forename: Yan-li
authors.initials: YL
authors.lastname: Nie
authors.forename: Ming-ming
authors.initials: MM
authors.lastname: Zhang
authors.forename: Yu-lin
authors.initials: YL
authors.lastname: Li
authors.forename: Jian-rong
authors.initials: JR
authors.lastname: Chen
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D015179:Colorectal Neoplasms / Q000188:drug therapy*; D005472:Fluorouracil / Q000627:therapeutic use*; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D005472:Fluorouracil