title: A Case of Mycobacterial Skin Disease Caused by Mycobacterium peregrinum, and a Review of Cutaneous Infection.
abstract: An 83-year-old Japanese man presented with a 2-month history of symptomatic nodules on the left hand. He was not in an immunocompromised condition and reported no causal events. A biopsy specimen demonstrated granulomatous tissue with mixed cell infiltration consisting of neutrophils, histiocytes, lymphocytes, and multinuclear giant cells. No bacillus was detected by PAS, acid-fast stain, immunofluorescent stain or polymerase chain reaction analysis. The isolate was found to be a rapidly growing mycobacterium after 4 weeks of incubation at 25°C on an Ogawa egg slant. Mycobacterium peregrinum was isolated by DNA-DNA hybridization analysis, 16S rRNA gene sequence, and by its production of 3-day arylsulfatase. The patient received 200 mg oral minocycline for 28 weeks. The lesion disappeared after 10 weeks of this treatment.
authors.affiliation: Department of Dermatology, Shinshu University School of Medicine, Matsumoto, Tokyo, Japan.
authors.forename: Fuminao
authors.initials: F
authors.lastname: Kamijo
authors.forename: Hisashi
authors.initials: H
authors.lastname: Uhara
authors.forename: Hitomi
authors.initials: H
authors.lastname: Kubo
authors.forename: Kazue
authors.initials: K
authors.lastname: Nakanaga
authors.forename: Yoshihiko
authors.initials: Y
authors.lastname: Hoshino
authors.forename: Norihisa
authors.initials: N
authors.lastname: Ishii
authors.forename: Ryuhei
authors.initials: R
authors.lastname: Okuyama