title: Joint impact of physical activity and family history on the development of diabetes among urban adults in Mainland China: a pooled analysis of community-based prospective cohort studies.
abstract: To examine the joint influences of physical activity (PA) and family history (FH) of diabetes on subsequent type 2 diabetes (T2D), the authors pooled and analyzed data from 2 community-based urban adult prospective cohort studies in 2011 in Nanjing, China. Among 4550 urban participants, the 3-year cumulative incidence of T2D was 5.1%. After adjustment for potential confounders, compared with those with FH+ and insufficient PA, the adjusted odds ratio (95% confidence interval) of developing T2D was 0.42 (0.18, 0.98) for participants with sufficient PA and FH+, 0.32 (0.22, 0.46) for participants with insufficient PA and FH-, and 0.15 (0.08, 0.28) for participants with sufficient PA and FH-. Such significant graduated associations between PA/FH and risk of developing T2D were also identified in either men or women, separately. Sufficient PA and FH- may jointly reduce the risk of developing T2D in urban Chinese adults.
authors.affiliation: Nanjing Municipal Center for Disease Control and Prevention, Nanjing, China Nanjing Medical University, Nanjing, China f.xufei@gmail.com.
authors.forename: Fei
authors.initials: F
authors.lastname: Xu
authors.affiliation: Johns Hopkins University, Baltimore, MD, USA.
authors.forename: Youfa
authors.initials: Y
authors.lastname: Wang
authors.affiliation: The University of Queensland, Brisbane, Australia.
authors.forename: Robert S
authors.initials: RS
authors.lastname: Ware
authors.affiliation: The Chinese University of Hong Kong, Hong Kong, China.
authors.forename: Lap Ah
authors.initials: LA
authors.lastname: Tse
authors.affiliation: Nanjing Municipal Center for Disease Control and Prevention, Nanjing, China.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Wang
authors.affiliation: Nanjing Municipal Center for Disease Control and Prevention, Nanjing, China.
authors.forename: Xin
authors.initials: X
authors.lastname: Hong
authors.affiliation: Baker IDI Heart and Diabetes Institute, Melbourne, Australia.
authors.forename: David W
authors.initials: DW
authors.lastname: Dunstan
authors.affiliation: The University of Queensland, Brisbane, Australia Baker IDI Heart and Diabetes Institute, Melbourne, Australia.
authors.forename: Neville
authors.initials: N
authors.lastname: Owen
mesh_terms: D000328:Adult; D044466:Asian People; D002681:China / Q000453:epidemiology; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology*; D005192:Family Health; D005260:Female; D006801:Humans; D015994:Incidence; D007592:Joint Diseases; D008297:Male; D009043:Motor Activity; D011446:Prospective Studies; D011795:Surveys and Questionnaires; D014505:Urban Population