title: Duration of detection of anti-BmR1 IgG4 antibodies after mass-drug administration (MDA) in Sarawak, Malaysia.
abstract: The detection rates of brugian filariasis in three regions of Sarawak namely Central,   North and South after three courses of mass drug administration (MDA) from year 2004 to   2006 was investigated. A recombinant BmR1 antigen-based IgG4 detection test, named   Brugia Rapid and night blood smear for microfilaria (mf) detection were used. All three   regions recorded a sharp fall in mf positive rates after a year post-MDA. Meanwhile Brugia   Rapid positive rates declined more gradually to 3.8% and 5.6% of the pre-MDA levels in the   Central and North regions, respectively. This study showed that in filariasis endemic areas in   Sarawak, anti-filarial IgG4 antibodies to BmR1, as detected by the Brugia Rapid test, were   positive for one to two years after mf disappearance.
authors.affiliation: Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, Penang, Malaysia. rahmah8485@gmail.com
authors.forename: R
authors.initials: R
authors.lastname: Noordin
authors.forename: J
authors.initials: J
authors.lastname: Muhi
authors.forename: Z
authors.initials: Z
authors.lastname: Md Idris
authors.forename: N
authors.initials: N
authors.lastname: Arifin
authors.forename: A
authors.initials: A
authors.lastname: Kiyu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood*; D000947:Antigens, Helminth; D002009:Brugia / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D004358:Drug Therapy / Q000379:methods*; D004605:Elephantiasis, Filarial / Q000188:drug therapy* / Q000453:epidemiology / Q000276:immunology*; D005369:Filaricides / Q000008:administration & dosage*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D008296:Malaysia / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins; D016036:Seroepidemiologic Studies; D013997:Time Factors; D055815:Young Adult
chemical_list: D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D005369:Filaricides; D007074:Immunoglobulin G; D011994:Recombinant Proteins