title: Association of complete recovery from acute kidney injury with incident CKD stage 3 and all-cause mortality.
abstract: BACKGROUND
  There is a gap of knowledge in the long-term outcomes of patients who have complete recovery of kidney function after an episode of acute kidney injury (AKI). We sought to determine whether complete recovery of kidney function after an episode of AKI is associated with the development of incident stage 3 chronic kidney disease (CKD) and mortality in patients with normal baseline kidney function.
  
  
  METHODS
  Retrospective cohort study.
  
  
  METHODS
  3,809 patients from an integrated health care delivery system who had a hospitalization between January 1, 1999, and December 31, 2009, with follow-up through March 31, 2010.
  
  
  METHODS
  AKI defined by International Classification of Diseases, Ninth Revision (ICD-9) codes and using the AKI Network (AKIN) definition, with complete recovery defined as a decrease in serum creatinine level to less than 1.10 times the baseline value.
  
  
  METHODS
  Incident stage 3 CKD persistent for 3 months and all-cause mortality.
  
  
  RESULTS
  After a median follow-up of 2.5 years, incident stage 3 CKD occurred in 15% and 3% of those with and without AKI, respectively, with an unadjusted HR of 5.93 (95% CI, 4.49-7.84) and HR of 3.82 (95% CI, 2.81-5.19) in propensity score-stratified analyses. Deaths occurred in 35% and 24% of those with and without AKI, respectively, with an unadjusted HR of 1.46 (95% CI, 1.27-1.68). In propensity score-stratified analyses, HR decreased to 1.08 (95% CI, 0.93-1.27).
  
  
  CONCLUSIONS
  Measurements of albuminuria were not available.
  
  
  CONCLUSIONS
  Complete recovery of kidney function after an episode of AKI in patients with normal baseline kidney function is associated with increased risk of the development of incident stage 3 CKD, but not all-cause mortality.
authors.affiliation: Research & Evaluation, Kaiser Permanente Southern California, Pasadena, CA, USA.
authors.forename: Jason
authors.initials: J
authors.lastname: Jones
authors.forename: John
authors.initials: J
authors.lastname: Holmen
authors.forename: Jennifer
authors.initials: J
authors.lastname: De Graauw
authors.forename: Anna
authors.initials: A
authors.lastname: Jovanovich
authors.forename: Sid
authors.initials: S
authors.lastname: Thornton
authors.forename: Michel
authors.initials: M
authors.lastname: Chonchol
mesh_terms: D058186:Acute Kidney Injury / Q000145:classification* / Q000453:epidemiology* / Q000503:physiopathology / Q000628:therapy; D017677:Age Distribution; D000368:Aged; D016022:Case-Control Studies; D002423:Cause of Death; D015897:Comorbidity; D016001:Confidence Intervals; D003404:Creatinine / Q000097:blood; D018450:Disease Progression; D005260:Female; D017052:Hospital Mortality / Q000639:trends; D006801:Humans; D015994:Incidence; D038801:International Classification of Diseases; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D020127:Recovery of Function; D051436:Renal Insufficiency, Chronic / Q000145:classification / Q000453:epidemiology* / Q000503:physiopathology / Q000628:therapy; D012189:Retrospective Studies; D012720:Severity of Illness Index; D017678:Sex Distribution; D016019:Survival Analysis; D013997:Time Factors
chemical_list: D003404:Creatinine