title: The role of mannose-binding lectin in pneumococcal infection.
abstract: The role of mannose-binding lectin (MBL) deficiency (MBL2; XA/O and O/O genotypes) in host defences remains controversial. The surfactant proteins (SP)-A1, -A2 and -D, other collectins whose genes are located near MBL2, are part of the first-line lung defence against infection. We analysed the role of MBL on susceptibility to pneumococcal infection and the existence of linkage disequilibrium (LD) among the four genes. We studied 348 patients with pneumococcal community-acquired pneumonia (P-CAP) and 2,110 controls. A meta-analysis of MBL2 genotypes in susceptibility to P-CAP and to invasive pneumococcal disease (IPD) was also performed. The extent of LD of MBL2 with SFTPA1, SFTPA2 and SFTPD was analysed. MBL2 genotypes did not associate with either P-CAP or bacteraemic P-CAP in the case-control study. The MBL-deficient O/O genotype was significantly associated with higher risk of IPD in a meta-analysis, whereas the other MBL-deficient genotype (XA/O) showed a trend towards a protective role. We showed the existence of LD between MBL2 and SP genes. The data do not support a role of MBL deficiency on susceptibility to P-CAP or to IPD. LD among MBL2 and SP genes must be considered in studies on the role of MBL in infectious diseases.
authors.affiliation: Dept of Immunology, Hospital Universitario de Gran Canaria Dr Negrín, Las Palmas de Gran Canaria, Spain.
authors.forename: M Isabel
authors.initials: MI
authors.lastname: García-Laorden
authors.forename: Felipe
authors.initials: F
authors.lastname: Rodríguez de Castro
authors.forename: Jordi
authors.initials: J
authors.lastname: Solé-Violán
authors.forename: Antoni
authors.initials: A
authors.lastname: Payeras
authors.forename: M Luisa
authors.initials: ML
authors.lastname: Briones
authors.forename: Luis
authors.initials: L
authors.lastname: Borderías
authors.forename: Javier
authors.initials: J
authors.lastname: Aspa
authors.forename: José
authors.initials: J
authors.lastname: Blanquer
authors.forename: Olga
authors.initials: O
authors.lastname: Rajas
authors.forename: J Alberto
authors.initials: JA
authors.lastname: Marcos-Ramos
authors.forename: Estefanía
authors.initials: E
authors.lastname: Herrera-Ramos
authors.forename: Miguel A
authors.initials: MA
authors.lastname: García-Bello
authors.forename: Judith
authors.initials: J
authors.lastname: Noda
authors.forename: José M
authors.initials: JM
authors.lastname: Ferrer
authors.forename: Jordi
authors.initials: J
authors.lastname: Rello
authors.forename: Carlos
authors.initials: C
authors.lastname: Rodríguez-Gallego
mesh_terms: D017714:Community-Acquired Infections / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D037601:Mannose-Binding Lectin / Q000235:genetics*; D008875:Middle Aged; D011018:Pneumonia, Pneumococcal / Q000235:genetics*; D011446:Prospective Studies
chemical_list: D037601:Mannose-Binding Lectin