title: [Uric acid, atherosclerosis and vascular calcifications in chronic kidney disease].
abstract: Abstract. Epidemiological and clinical studies have shown that cardiovascular disease is associated with an increase in mortality in patients with chronic kidney disease (CKD). Vascular complications are mainly secondary to calcification and atherosclerosis. Interest in the association between uric acid levels and cardiovascular risk has been renewed in recent years. The objective of this research was to determine the relation between vascular calcification (VC) and atherosclerosis, through carotid ultrasound, with uric acid levels in patients with CKD in dialysis. VCs were observed in 56% of patients, 46% had ultrasound criteria for atherosclerosis with an overall average of 0.89 mm (SD +/- 0.28), being higher in patients with hypertension and diabetes; this group also showed increased susceptibility to VC (p = 0.01). The levels of urea (141.3 mg/dL) (p = 0.01) and uric acid (6.9 mg/dL) (p = 0.04) showed significant association with the presence of VC. Adverse cardiovascular events were observed mainly in patients with atherosclerosis and VC (p = 0.01). This investigation showed that an increase in uric acid levels above 6 mg/dL is associated with an increased risk of calcification and cardiovascular adverse events in CKD patients in dialysis.
authors.affiliation: Hospital Universitario Ruiz y Páez, Servicio de Nefrología, Ciudad Bolívar, Caracas, Venezuela. luisgerardodg@hotmail.com
authors.forename: Luis
authors.initials: L
authors.lastname: D'Marco
authors.forename: Irene
authors.initials: I
authors.lastname: García
authors.forename: Claudia
authors.initials: C
authors.lastname: Vega
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D050197:Atherosclerosis / Q000453:epidemiology*; D002114:Calcinosis / Q000097:blood / Q000453:epidemiology*; D002318:Cardiovascular Diseases / Q000453:epidemiology; D002908:Chronic Disease; D015897:Comorbidity; D003404:Creatinine / Q000097:blood; D003430:Cross-Sectional Studies; D003928:Diabetic Nephropathies / Q000097:blood / Q000453:epidemiology / Q000628:therapy; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D006973:Hypertension / Q000453:epidemiology; D033461:Hyperuricemia / Q000453:epidemiology; D007674:Kidney Diseases / Q000097:blood / Q000150:complications / Q000453:epidemiology* / Q000628:therapy; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D006435:Renal Dialysis; D012306:Risk; D014527:Uric Acid / Q000097:blood*; D014687:Venezuela / Q000453:epidemiology; D055815:Young Adult
chemical_list: D008055:Lipids; D014527:Uric Acid; D003404:Creatinine