title: Molecular genetics of head and neck cancer (Review).
abstract: Understanding of molecular regulatory pathways presents a novel therapeutic approach for the treatment of head and neck cancer. These specific check points are becoming the targeted therapeutic approach. In this review, we highlight certain major signaling mechanisms, which are involved in the pathophysiology of head and neck cancer. Also, we discuss the current ongoing trials based on the in vitro success of targeted therapies.
authors.affiliation: Department of Internal Medicine, Wyckoff Heights Medical Center,                     New York-Presbyterian Health Care System, affiliated with Weil Medical                     College of Cornell University, New York, NY 11237, USA.
authors.forename: Shitij
authors.initials: S
authors.lastname: Arora
authors.forename: Prachi
authors.initials: P
authors.lastname: Aggarwal
authors.forename: Amit
authors.initials: A
authors.lastname: Pathak
authors.forename: Rekha
authors.initials: R
authors.lastname: Bhandari
authors.forename: Frantz
authors.initials: F
authors.lastname: Duffoo
authors.forename: Subhash C
authors.initials: SC
authors.lastname: Gulati
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000378:metabolism; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000235:genetics / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D006258:Head and Neck Neoplasms / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D012106:Research / Q000639:trends; D015398:Signal Transduction; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism
chemical_list: D019941:Cyclin-Dependent Kinase Inhibitor p16; D016159:Tumor Suppressor Protein p53