title: Serum soluble death receptor 5 concentration in patients with chronic hepatitis B is associated with liver damage and viral antigen level.
abstract: OBJECTIVE
  To measure the levels of serum soluble death receptor 5 (sDR5) in patients with hepatitis B.
  
  
  METHODS
  sDR5 concentration in 60 HBV infected patients and 30 healthy volunteers were measured by ELISA.
  
  
  RESULTS
  sDR5 concentration in the HBV infected patients was decreased and correlated with serum ALT, Tbil level, albumin/globulin ratio and HBV antigen level.
  
  
  CONCLUSIONS
  Decreased serum sDR5 is associated with high level of liver damage and inhibited HBV antigen expression.
authors.affiliation: Key Laboratory for Experimental Teratology of Ministry of Education and Institute of Immunology, Shandong University School of Medicine, 44 Wenhua Xi Road, Jinan 250012, PR China.
authors.forename: Juan
authors.initials: J
authors.lastname: Du
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Jianjun
authors.initials: J
authors.lastname: Han
authors.forename: Lifen
authors.initials: L
authors.lastname: Gao
authors.forename: Chunhong
authors.initials: C
authors.lastname: Ma
authors.forename: Xiaohong
authors.initials: X
authors.lastname: Liang
mesh_terms: D000410:Alanine Transaminase / Q000097:blood / Q000276:immunology; D000956:Antigens, Viral / Q000097:blood / Q000276:immunology*; D001219:Aspartate Aminotransferases / Q000097:blood / Q000276:immunology; D001663:Bilirubin / Q000097:blood / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D006514:Hepatitis B Surface Antigens / Q000097:blood / Q000276:immunology; D006513:Hepatitis B e Antigens / Q000097:blood / Q000276:immunology; D006515:Hepatitis B virus / Q000276:immunology / Q000502:physiology; D019694:Hepatitis B, Chronic / Q000097:blood / Q000276:immunology* / Q000821:virology; D054884:Host-Pathogen Interactions / Q000276:immunology; D006801:Humans; D008099:Liver / Q000276:immunology* / Q000473:pathology / Q000821:virology; D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand / Q000097:blood / Q000276:immunology*; D012995:Solubility
chemical_list: D000956:Antigens, Viral; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens; D053220:Receptors, TNF-Related Apoptosis-Inducing Ligand; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001663:Bilirubin