title: Comparison of MRI and ¹⁸F-NaF PET/CT in patients with patellofemoral pain.
abstract: OBJECTIVE
  To determine whether bone metabolic activity corresponds to bone and cartilage damage in patients with patellofemoral pain.
  
  
  METHODS
  We acquired magnetic resonance imaging (MRI) and (18) F-NaF positron emission tomography (PET) / computed tomography (CT) scans of the knees of 22 subjects. We compared locations of increased tracer uptake on the (18) F-NaF PET images to bone marrow edema and cartilage damage visualized on MRI.
  
  
  RESULTS
  We found that increased bone activity on (18) F-NaF PET does not always correspond to structural damage in the bone or cartilage as seen on MRI.
  
  
  CONCLUSIONS
  Our results suggest that (18) F-NaF PET/CT may provide additional information in patellofemoral pain patients compared to MRI.
authors.affiliation: Department of Radiology, Stanford University, Stanford, California, USA.
authors.forename: Christine E
authors.initials: CE
authors.lastname: Draper
authors.forename: Andrew
authors.initials: A
authors.lastname: Quon
authors.forename: Michael
authors.initials: M
authors.lastname: Fredericson
authors.forename: Thor F
authors.initials: TF
authors.lastname: Besier
authors.forename: Scott L
authors.initials: SL
authors.lastname: Delp
authors.forename: Gary S
authors.initials: GS
authors.lastname: Beaupre
authors.forename: Garry E
authors.initials: GE
authors.lastname: Gold
mesh_terms: D000328:Adult; D005260:Female; D005462:Fluorine Radioisotopes; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D064847:Multimodal Imaging / Q000379:methods*; D046788:Patellofemoral Pain Syndrome / Q000175:diagnosis*; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D012969:Sodium Fluoride; D014057:Tomography, X-Ray Computed
chemical_list: D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D012969:Sodium Fluoride