title: The gender difference of selective serotonin reuptake inhibitor, fluoxetine in adult rats with stress-induced gastric ulcer.
abstract: We investigated the gender difference of selective serotonin reuptake inhibitor, fluoxetine in adult rats with stress-induced gastric ulcer. The rats were randomly divided into six groups: Group I, control males and group II, control females; group III, acute cold restraint stressed males and group IV, acute cold restraint stressed females; group V, fluoxetine-treated stressed males and group VI, fluoxetine-treated stressed females. Acute cold restraint stress was established by fixing the four limbs of the rat and placing it in a refrigerator at 4°C for 3h. Fluoxetine was given intraperitoneal in a single dose of 10mg/kg/day. After 2 weeks, stomach and brain tissues were collected for the assay of gastric malonaldehyde (MDA), catalase, nitric oxide (NO) and cortical gamma aminobutyric acid (GABA). Stressed animals exhibited increased total acidity in association with decreased gastric secretion volume. Gastric MDA was increased while gastric catalase, NO, and cortical GABA were decreased in stressed male rats when compared to stressed females. However, fluoxetine administration attenuated these stress-induced changes especially in stressed male animals. Stressed male rats were more responsive to the antiulcer effect of fluoxetine more than stressed females. However, fluoxetine might be considered to be the first-choice drug in depressive patients with gastric ulcers in the future.
authors.affiliation: Rabigh Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia; Al-Azher Faculty of Medicine, Assiut, Egypt. Khaled_71111@yahoo.com
authors.forename: Khaled A
authors.initials: KA
authors.lastname: Abdel-Sater
authors.forename: Wafaa M
authors.initials: WM
authors.lastname: Abdel-Daiem
authors.forename: Mohamad
authors.initials: M
authors.lastname: Sayyed Bakheet
mesh_terms: D000818:Animals; D002374:Catalase / Q000378:metabolism; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D005260:Female; D005473:Fluoxetine / Q000494:pharmacology* / Q000627:therapeutic use; D005753:Gastric Mucosa / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D012727:Sex Characteristics; D013270:Stomach / Q000187:drug effects; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000209:etiology* / Q000378:metabolism; D013315:Stress, Psychological / Q000150:complications*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D002374:Catalase; D005473:Fluoxetine; D008315:Malondialdehyde; D009569:Nitric Oxide; D017367:Selective Serotonin Reuptake Inhibitors; D005680:gamma-Aminobutyric Acid