title: [Heat shock proteins: aging changes, development thrombotic diseases and peptidergic regulation of genes].
abstract: The review and the data of our own investigation demonstrated the role of heat shock proteins in regulation of intracellular and tissue homeostasis at stress influence. The review told that decrease of expression of heat shock proteins can be one of the main causes of aging. Heat shock proteins, which are regulators of proliferation, apoptosis, differentiation of cells and intracellular homeostasis, play important role in activity of immune, cardiovascular and other systems and take part in development of atherosclerosis, heart attack, ischemic stroke and other thrombotic diseases. One of the ways to repair the expression of heat shock proteins is using short peptides.
authors.forename: B I
authors.initials: BI
authors.lastname: Kuznik
authors.forename: N S
authors.initials: NS
authors.lastname: Lin'kova
authors.forename: V Kh
authors.initials: VKh
authors.lastname: Khavinson
mesh_terms: D000375:Aging / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D002468:Cell Physiological Phenomena / Q000235:genetics / Q000528:radiation effects; D002690:Chlamydia Infections / Q000150:complications / Q000378:metabolism / Q000382:microbiology; D016993:Chlamydophila pneumoniae / Q000302:isolation & purification; D005786:Gene Expression Regulation; D006360:Heat-Shock Proteins / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000378:metabolism; D018869:Heat-Shock Response / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology / Q000528:radiation effects; D006358:Hot Temperature; D006801:Humans; D009747:Nutritional Physiological Phenomena; D058226:Plaque, Atherosclerotic / Q000378:metabolism / Q000382:microbiology; D013923:Thromboembolism / Q000378:metabolism*
chemical_list: D006360:Heat-Shock Proteins