title: Holding on to stemness.
abstract: The attachment of stem cells to specialized functional niches instructs stem cell maintenance, with loss of adhesion associated with differentiation driven by cell-intrinsic programs. Id transcription factors are now shown to link cell-intrinsic maintenance programs and extrinsic cues by promoting adhesion of neural stem cells to the niche.
authors.affiliation: Department of Cell Biology, Lerner Research Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio 44195, USA. lathiaj@ccf.org
authors.forename: Justin D
authors.initials: JD
authors.lastname: Lathia
authors.forename: Jeremy N
authors.initials: JN
authors.lastname: Rich
mesh_terms: D000818:Animals; D000951:Antigens, Neoplasm / Q000502:physiology*; D002448:Cell Adhesion / Q000502:physiology*; D058953:Neural Stem Cells / Q000166:cytology*
chemical_list: D000951:Antigens, Neoplasm; C464525:Id tumor-specific protein, mouse