title: Remarkably fast and selective aromatization of Hantzsch esters with MoOCl4 and MoCl5: a chemical model for possible biologically relevant properties of molybdenum-containing enzymes.
abstract: Mo(VI) and Mo(V) salts both react selectively with Hantzsch esters to produce substitute pyridines in good-to-excellent yield (75-99%). The remarkable reactivity and selectivity of MoOCl(4) under reflux of acetonitrile and MoCl(5) in dichloromethane at room temperature encouraged us to propose that molybdenum-containing enzymes (such as xanthine or aldehyde oxidase) also participate to some degree in the metabolism of 1,4-dihydropyridine drugs in the liver analogous to NADH in the respiratory chain.
authors.affiliation: BELUPO Pharmaceuticals, Inc., R&D, Koprivnica, Croatia. mladen.litvic@belupo.hr
authors.forename: Mladen
authors.initials: M
authors.lastname: Litvić
authors.forename: Maja
authors.initials: M
authors.lastname: Regović
authors.forename: Karolina
authors.initials: K
authors.lastname: Smic
authors.forename: Marija
authors.initials: M
authors.lastname: Lovrić
authors.forename: Mirela
authors.initials: M
authors.lastname: Filipan-Litvić
mesh_terms: D042931:Aldehyde Oxidase / Q000378:metabolism*; D002712:Chlorides / Q000737:chemistry*; D004095:Dihydropyridines / Q000737:chemistry / Q000378:metabolism; D004952:Esters; D008956:Models, Chemical; D008982:Molybdenum / Q000737:chemistry*; D014969:Xanthine Oxidase / Q000378:metabolism*
chemical_list: D002712:Chlorides; D004095:Dihydropyridines; D004952:Esters; C038806:1,4-dihydropyridine; D008982:Molybdenum; C085192:molybdenum chloride; D014969:Xanthine Oxidase; D042931:Aldehyde Oxidase