title: BEAMing up personalized medicine: mutation detection in blood.
abstract: BEAMing is a feasible, accurate, and sensitive method for detection of PIK3CA mutations in circulating tumor DNA in blood. Mutation status of PIK3CA may change between primary tumor and recurrence. The results suggest a new approach for noninvasive determination of current mutation status in patients with metastatic disease.
authors.affiliation: Department of Pathology and Surgery, Brigham and Women's Hospital; Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA. arichardson@partners.org
authors.forename: Andrea L
authors.initials: AL
authors.lastname: Richardson
authors.forename: J Dirk
authors.initials: JD
authors.lastname: Iglehart
mesh_terms: D001943:Breast Neoplasms / Q000097:blood / Q000235:genetics*; D058534:Class I Phosphatidylinositol 3-Kinases; D004273:DNA, Neoplasm / Q000097:blood* / Q000235:genetics*; D005260:Female; D006801:Humans; D050505:Mutant Proteins / Q000097:blood; D009154:Mutation; D009362:Neoplasm Metastasis / Q000235:genetics; D019869:Phosphatidylinositol 3-Kinases / Q000097:blood* / Q000235:genetics*; D057285:Precision Medicine; D012680:Sensitivity and Specificity
chemical_list: D004273:DNA, Neoplasm; D050505:Mutant Proteins; D019869:Phosphatidylinositol 3-Kinases; D058534:Class I Phosphatidylinositol 3-Kinases; C484760:PIK3CA protein, human