title: Study of echocardiographic alterations in the first six months after kidney transplantation.
abstract: BACKGROUND
  Cardiac disorders are very common in individuals with chronic kidney disease and are associated with morbimortality.
  
  
  OBJECTIVE
  To evaluate cardiac alterations after kidney transplantation.
  
  
  METHODS
  We prospectively evaluated 40 patients with chronic kidney disease, immediately before and one month, three months and six months after kidney transplantation, using tissue Doppler echocardiographic study. The left ventricular mass, systolic and diastolic function parameters were analyzed.
  
  
  RESULTS
  The mean age was 31.6 years and 40% of patients were female. We observed a reduction in left ventricular diastolic diameter (52.23 to 49.95 mm, p = 0.021) and LV mass index (131.48 to 113.039 g/m2, p = 0.002) after kidney transplantation. The mean E/e' decreased in the third and sixth months after kidney transplantation, when compared to basal values (8.13 and 7.85 vs. 9.79, p <0.05). The ejection fraction increased from the first month after kidney transplantation compared to basal assessment (69.72% vs. 65.68%, p <0.05). The prevalence of diastolic dysfunction decreased 43% during the evaluated period. The basal ejection fraction and mean E/e' were associated with reduced LV mass index after kidney transplantation. The LV mass index at baseline, female sex and decrease in serum phosphorus were associated with a reduction in the mean E/e ' ratio after kidney transplantation.
  
  
  CONCLUSIONS
  Kidney transplantation resulted in significant alterations in Doppler echocardiographic parameters of LV mass, systolic and diastolic function in patients with chronic kidney disease.
authors.affiliation: Hospital Universitário, Universidade Federal do Maranhão, São Luis, MA, Brasil. francival@cardiol.br
authors.forename: Francival Leite de
authors.initials: FL
authors.lastname: Souza
authors.forename: Karenn Barros
authors.initials: KB
authors.lastname: Bezerra
authors.forename: Andréa Rodrigues
authors.initials: AR
authors.lastname: Sousa
authors.forename: Teresa Cristina Alves
authors.initials: TC
authors.lastname: Ferreira
authors.forename: Maria Inês Gomes
authors.initials: MI
authors.lastname: Oliveira
authors.forename: Giovanna Parada
authors.initials: GP
authors.lastname: Martins
authors.forename: Fernando Alberto Costa Cardoso
authors.initials: FA
authors.lastname: Silva
authors.forename: Alcione Miranda
authors.initials: AM
authors.lastname: Santos
authors.forename: Natalino
authors.initials: N
authors.lastname: Salgado Filho
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity; D015150:Echocardiography, Doppler; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006331:Heart Diseases / Q000000981:diagnostic imaging; D006801:Humans; D007676:Kidney Failure, Chronic / Q000503:physiopathology*; D016030:Kidney Transplantation / Q000502:physiology*; D008297:Male; D015999:Multivariate Analysis; D009200:Myocardial Contraction / Q000502:physiology; D011446:Prospective Studies; D012737:Sex Factors; D013997:Time Factors