title: Pluronic F108 coating decreases the lung fibrosis potential of multiwall carbon nanotubes by reducing lysosomal injury.
abstract: We compared the use of bovine serum albumin (BSA) and pluronic F108 (PF108) as dispersants for multiwalled carbon nanotubes (MWCNTs) in terms of tube stability as well as profibrogenic effects in vitro and in vivo. While BSA-dispersed tubes were a potent inducer of pulmonary fibrosis, PF108 coating protected the tubes from damaging the lysosomal membrane and initiating a sequence of cooperative cellular events that play a role in the pathogenesis of pulmonary fibrosis. Our results suggest that PF108 coating could serve as a safer design approach for MWCNTs.
authors.affiliation: Division of NanoMedicine, Department of Medicine University of California, Los Angeles, California 90095, United States.
authors.forename: Xiang
authors.initials: X
authors.lastname: Wang
authors.forename: Tian
authors.initials: T
authors.lastname: Xia
authors.forename: Matthew C
authors.initials: MC
authors.lastname: Duch
authors.forename: Zhaoxia
authors.initials: Z
authors.lastname: Ji
authors.forename: Haiyuan
authors.initials: H
authors.lastname: Zhang
authors.forename: Ruibin
authors.initials: R
authors.lastname: Li
authors.forename: Bingbing
authors.initials: B
authors.lastname: Sun
authors.forename: Sijie
authors.initials: S
authors.lastname: Lin
authors.forename: Huan
authors.initials: H
authors.lastname: Meng
authors.forename: Yu-Pei
authors.initials: YP
authors.lastname: Liao
authors.forename: Meiying
authors.initials: M
authors.lastname: Wang
authors.forename: Tze-Bin
authors.initials: TB
authors.lastname: Song
authors.forename: Yang
authors.initials: Y
authors.lastname: Yang
authors.forename: Mark C
authors.initials: MC
authors.lastname: Hersam
authors.forename: André E
authors.initials: AE
authors.lastname: Nel
mesh_terms: D000280:Administration, Inhalation; D000818:Animals; D020099:Coated Materials, Biocompatible / Q000737:chemistry*; D008247:Lysosomes / Q000187:drug effects* / Q000473:pathology*; D051379:Mice; D037742:Nanotubes, Carbon / Q000633:toxicity*; D020442:Poloxamer / Q000737:chemistry*; D011658:Pulmonary Fibrosis / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control*
chemical_list: D020099:Coated Materials, Biocompatible; D037742:Nanotubes, Carbon; D020442:Poloxamer