title: [32P]ATP inhibits the growth of xenografted tumors in nude mice.
abstract: The search for new therapeutic agents that are effective against cancer has been difficult and expensive. The activity of anticancer candidate agents against human cancer-derived cell lines in immunocompromised mice is an important tool in this search. Because ATP is a naturally occurring small molecule, its radiolabeled form poses many advantages as a potential anticancer therapeutic agent. We previously found that a single, low-dose intravenous injection of [ ( 32) P]ATP inhibited the growth of xenografted tumors in nude mice for up to several weeks. The current study describes the biodistribution and the results and advantages of multi-dose administration of this potential drug. Future studies should investigate the mechanism involved in the possible use of [ ( 32) P]ATP as a cytotoxic agent that homes naturally to the tumor microenvironment.
authors.affiliation: Department of Medicine; The Johns Hopkins School of Medicine; Baltimore, MD USA.
authors.forename: Yulan
authors.initials: Y
authors.lastname: Cheng
authors.forename: Srinivasan
authors.initials: S
authors.lastname: Senthamizhchelvan
authors.forename: Rachana
authors.initials: R
authors.lastname: Agarwal
authors.forename: Gilbert M
authors.initials: GM
authors.lastname: Green
authors.forename: Ronnie C
authors.initials: RC
authors.lastname: Mease
authors.forename: George
authors.initials: G
authors.lastname: Sgouros
authors.forename: David L
authors.initials: DL
authors.lastname: Huso
authors.forename: Martin G
authors.initials: MG
authors.lastname: Pomper
authors.forename: Stephen J
authors.initials: SJ
authors.lastname: Meltzer
authors.forename: John M
authors.initials: JM
authors.lastname: Abraham
mesh_terms: D000255:Adenosine Triphosphate / Q000493:pharmacokinetics* / Q000627:therapeutic use; D000818:Animals; D000970:Antineoplastic Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D006367:HeLa Cells; D006801:Humans; D016867:Immunocompromised Host; D051379:Mice; D008819:Mice, Nude; D009369:Neoplasms / Q000188:drug therapy* / Q000473:pathology; D010761:Phosphorus Radioisotopes / Q000737:chemistry; D014018:Tissue Distribution; D014183:Transplantation, Heterologous
chemical_list: D000970:Antineoplastic Agents; D010761:Phosphorus Radioisotopes; D000255:Adenosine Triphosphate