title: Inoperable cerebral alveolar echinococcosis controlled with high dosages of albendazole adjusted with monitoring of blood levels.
abstract: Cerebral alveolar echinococcosis (AE) is a rare and difficult-to-treat zoonosis caused by Echinococcus multilocularis. A 29-year-old immigrant from Siberia with a past history of hepatic AE, presented with acute onset of grand mal seizures, weakness of the left leg, and cephalgia. Magnetic resonance imaging of the brain revealed inoperable right-sided infiltrative lesions, suggesting cerebral AE. Despite anthelmintic treatment only slow improvement occurred.
authors.affiliation: Section Tropical Medicine, Department of Internal Medicine I, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. stauga@bni-hamburg.de
authors.forename: Sabine
authors.initials: S
authors.lastname: Stauga
authors.forename: Stefan
authors.initials: S
authors.lastname: Schmiedel
mesh_terms: D000328:Adult; D015766:Albendazole / Q000008:administration & dosage* / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D000923:Anticestodal Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001927:Brain Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000469:parasitology*; D001929:Brain Edema / Q000469:parasitology / Q000473:pathology; D018450:Disease Progression; D016903:Drug Monitoring; D004443:Echinococcosis; D004444:Echinococcosis, Hepatic / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery; D054242:Emigrants and Immigrants; D005858:Germany; D006498:Hepatectomy; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012008:Recurrence; D012800:Siberia / Q000208:ethnology; D014195:Travel
chemical_list: D000923:Anticestodal Agents; D015766:Albendazole; C027186:albendazole sulfoxide