title: Clinical experience with daptomycin in Italy: results from a registry study of the treatment of Gram-positive infections between 2006 and 2009.
abstract: The purpose of this study was to evaluate post-marketing efficacy and safety data for therapy with daptomycin (DAP) in Italy. Data from patients treated with DAP at 30 centres between January 2006 and July 2009 were analysed according to the protocol of the EU-CORE(SM). In 359 patients, DAP was most commonly prescribed for skin and skin-structure infections (55%), infective endocarditis (13%), and bacteraemia (12.5%). DAP was associated with rapid improvement, and clinical success rates ranging from 77 to 91%, despite almost half of the patient population being ≥65 years of age, 86% having significant underlying disease, and many being affected by drug-resistant pathogens. Staphylococcus aureus represented 35% of all pathogens isolated. Success rates for all staphylococcal and enterococcal infections were >80%, including methicillin-resistant S. aureus (MRSA) and methicillin-susceptible S. aureus (MSSA). Clinical outcomes were similar for DAP whether used as first- or second-line therapy. DAP was well tolerated even with prolonged treatment.
authors.affiliation: Unit of Infectious and Transplant Medicine, Second University of Naples, Monaldi Hospital, Italy.
authors.forename: Riccardo
authors.initials: R
authors.lastname: Utili
authors.forename: Alberto
authors.initials: A
authors.lastname: Cogo
authors.forename: Francesco
authors.initials: F
authors.lastname: Cristini
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Prisco
authors.forename: Evangelista
authors.initials: E
authors.lastname: Sagnelli
authors.forename: Carlo
authors.initials: C
authors.lastname: Tascini
authors.forename: Cinzia
authors.initials: C
authors.lastname: Iacoboni
authors.forename: Alessandro
authors.initials: A
authors.lastname: Capone
authors.forename: Gianni
authors.initials: G
authors.lastname: Gattuso
authors.forename: Gioacchino
authors.initials: G
authors.lastname: Angarano
authors.forename: Enzo
authors.initials: E
authors.lastname: Petrelli
authors.forename: Paolo
authors.initials: P
authors.lastname: Grossi
authors.forename: Marta
authors.initials: M
authors.lastname: Bartezaghi
authors.forename: Emanuela
authors.initials: E
authors.lastname: Zagni
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D016470:Bacteremia / Q000188:drug therapy* / Q000382:microbiology; D017576:Daptomycin / Q000627:therapeutic use*; D004697:Endocarditis, Bacterial / Q000188:drug therapy* / Q000382:microbiology; D005260:Female; D006094:Gram-Positive Bacteria / Q000187:drug effects* / Q000254:growth & development / Q000302:isolation & purification; D016908:Gram-Positive Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D017576:Daptomycin