title: Chemical compositions and properties of Schinus areira L. essential oil on airway inflammation and cardiovascular system of mice and rabbits.
abstract: The main purpose was to investigate the effects of essential plant-oil of Schinus areira L. on hemodynamic functions in rabbits, as well as myocardial contractile strength and airways inflammation associated to bacterial endotoxin lipopolysaccharide (LPS) in mice. This study shows the important properties of the essential oil (EO) of S. areira studied and these actions on lung with significant inhibition associated to LPS, all of which was assessed in mice bronchoalveolar lavage fluid and evidenced by stability of the percentage of alveolar macrophages, infiltration of polymorphonuclear leukocytes and tumor necrosis factor-α concentration, and without pathway modifications in conjugated dienes activity. Clinical status (morbidity or mortality), macroscopic morphology and lung/body weight index were unaffected by the administration of the EO S. areira. Furthermore, the ex vivo analysis of isolated hearts demonstrated the negative inotropic action of the EO of S. areira in a mice model, and in rabbits changes in the hemodynamic parameters, such as a reduction of systolic blood pressure. We conclude that EO S. areira could be responsible for modifications on the cardiovascular and/or airway parameters.
authors.affiliation: Cátedra de Fisiología Humana, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Santa Rosa, Córdoba, Argentina.
authors.forename: María C
authors.initials: MC
authors.lastname: Bigliani
authors.forename: Víctor
authors.initials: V
authors.lastname: Rossetti
authors.forename: Ezequiel
authors.initials: E
authors.lastname: Grondona
authors.forename: Silvina
authors.initials: S
authors.lastname: Lo Presti
authors.forename: Patricia M
authors.initials: PM
authors.lastname: Paglini
authors.forename: Virginia
authors.initials: V
authors.lastname: Rivero
authors.forename: María P
authors.initials: MP
authors.lastname: Zunino
authors.forename: Andrés A
authors.initials: AA
authors.lastname: Ponce
mesh_terms: D000818:Animals; D001992:Bronchoalveolar Lavage Fluid; D002319:Cardiovascular System / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects; D007249:Inflammation / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology*; D008070:Lipopolysaccharides / Q000633:toxicity; D016676:Macrophages, Alveolar / Q000473:pathology; D008297:Male; D051379:Mice; D009200:Myocardial Contraction / Q000187:drug effects; D009822:Oils, Volatile / Q000737:chemistry / Q000494:pharmacology*; D009929:Organ Size; D018384:Oxidative Stress / Q000187:drug effects; D011817:Rabbits; D014132:Trachea / Q000187:drug effects* / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D008070:Lipopolysaccharides; D009822:Oils, Volatile; D014409:Tumor Necrosis Factor-alpha