title: Association between arsenic exposure from drinking water and plasma levels of cardiovascular markers.
abstract: The authors conducted a cross-sectional study to assess the relation between arsenic exposure from drinking water and plasma levels of markers of systemic inflammation and endothelial dysfunction (matrix metalloproteinase-9, myeloperoxidase, plasminogen activator inhibitor-1, soluble E-selectin, soluble intercellular adhesion molecule-1 (ICAM-1), and soluble vascular adhesion molecule-1 (VCAM-1)) using baseline data from 668 participants (age, >30 years) in the Health Effects of Arsenic Longitudinal Study in Bangladesh (2007-2008). Both well water arsenic and urinary arsenic were positively associated with plasma levels of soluble VCAM-1. For every 1-unit increase in log-transformed well water arsenic (ln μg/L) and urinary arsenic (ln μg/g creatinine), plasma soluble VCAM-1 was 1.02 (95% confidence interval: 1.01, 1.03) and 1.04 (95% confidence interval: 1.01, 1.07) times greater, respectively. There was a significant interaction between arsenic exposure and higher body mass index, such that the increased levels of plasminogen activator inhibitor-1 and soluble VCAM-1 associated with arsenic exposure were stronger among people with higher body mass index. The findings indicate an effect of chronic arsenic exposure from drinking water on vascular inflammation and endothelial dysfunction that could be modified by body mass index and also suggest a potential mechanism underlying the association between arsenic exposure and cardiovascular disease.
authors.affiliation: Department of Environmental Medicine, New York University School of Medicine, New York, USA.
authors.forename: Fen
authors.initials: F
authors.lastname: Wu
authors.forename: Farzana
authors.initials: F
authors.lastname: Jasmine
authors.forename: Muhammad G
authors.initials: MG
authors.lastname: Kibriya
authors.forename: Mengling
authors.initials: M
authors.lastname: Liu
authors.forename: Oktawia
authors.initials: O
authors.lastname: Wójcik
authors.forename: Faruque
authors.initials: F
authors.lastname: Parvez
authors.forename: Ronald
authors.initials: R
authors.lastname: Rahaman
authors.forename: Shantanu
authors.initials: S
authors.lastname: Roy
authors.forename: Rachelle
authors.initials: R
authors.lastname: Paul-Brutus
authors.forename: Stephanie
authors.initials: S
authors.lastname: Segers
authors.forename: Vesna
authors.initials: V
authors.lastname: Slavkovich
authors.forename: Tariqul
authors.initials: T
authors.lastname: Islam
authors.forename: Diane
authors.initials: D
authors.lastname: Levy
authors.forename: Jacob L
authors.initials: JL
authors.lastname: Mey
authors.forename: Alexander
authors.initials: A
authors.lastname: van Geen
authors.forename: Joseph H
authors.initials: JH
authors.lastname: Graziano
authors.forename: Habibul
authors.initials: H
authors.lastname: Ahsan
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
mesh_terms: D000328:Adult; D001151:Arsenic / Q000032:analysis / Q000633:toxicity*; D001459:Bangladesh; D015415:Biomarkers / Q000097:blood*; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000097:blood / Q000139:chemically induced*; D003430:Cross-Sectional Studies; D060766:Drinking Water / Q000737:chemistry*; D019040:E-Selectin / Q000097:blood; D004730:Endothelium, Vascular / Q000187:drug effects / Q000503:physiopathology; D004781:Environmental Exposure / Q000009:adverse effects* / Q000032:analysis; D005260:Female; D006801:Humans; D007249:Inflammation / Q000097:blood / Q000139:chemically induced; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D016014:Linear Models; D008137:Longitudinal Studies; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood; D008875:Middle Aged; D009195:Peroxidase / Q000097:blood; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D011446:Prospective Studies; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood; D014874:Water Pollutants, Chemical / Q000032:analysis / Q000633:toxicity*; D014877:Water Pollution, Chemical / Q000009:adverse effects* / Q000032:analysis
chemical_list: D015415:Biomarkers; D060766:Drinking Water; D019040:E-Selectin; C573420:ICAM1 protein, human; D017395:Plasminogen Activator Inhibitor 1; C051321:SERPINE1 protein, human; D019010:Vascular Cell Adhesion Molecule-1; D014874:Water Pollutants, Chemical; D018799:Intercellular Adhesion Molecule-1; D009195:Peroxidase; D020780:Matrix Metalloproteinase 9; D001151:Arsenic