title: [Toxic epidermal necrolysis during therapy with sulphasalazine in a patient with arthritis. Case report].
abstract: Toxic epidermal necrolysis (TEN) is a severe, life-threatening disease appearing after certain drugs, characterized by keratinocyte necrosis, which shows with painful cutaneous and mucosal exfoliation and systemic involvement. TEN mortality rate is between 30% to 70%, so patients need early administration of medical care. We report a case of a 40-year old woman with TEN-like symptoms, who received treatment with sulphasalazine for 3 weeks because of arthritis. Various diagnostic procedures were performed which caused many doubts about diagnosis. In differential diagnosis we thought about: firstly TEN after treatment with sulphasalazine--patient with systemic lupus erythematosus, secondly toxic epidermal necrolisis like lupus erythematosus, finally TEN and LE after treatment with sulpasalazine--patient with rheumatoid arthritis. Final diagnosis needs more investigation and further diagnostic procedures. The patient stays under our control.
authors.affiliation: Klinika Reumatologii i Chorób Wewnetrznych, AM we Wrocławiu. kasiasiek@poczta.onet.pl
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Rachwał-Siek
authors.forename: Monika
authors.initials: M
authors.lastname: Ponikowska
authors.forename: Piotr
authors.initials: P
authors.lastname: Wiland
mesh_terms: D000328:Adult; D018501:Antirheumatic Agents / Q000009:adverse effects*; D001168:Arthritis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D013262:Stevens-Johnson Syndrome / Q000175:diagnosis / Q000209:etiology*; D012460:Sulfasalazine / Q000009:adverse effects*
chemical_list: D018501:Antirheumatic Agents; D012460:Sulfasalazine