title: Prediction of early response to uterine arterial embolisation of adenomyosis: value of T2 signal intensity ratio of adenomyosis.
abstract: OBJECTIVE
  To identify imaging predictors for complete necrosis after uterine artery embolisation (UAE) via quantitative measurement of the signal intensity obtained from magnetic resonance imaging (MRI) of a patient with adenomyosis.
  
  
  METHODS
  The MRIs of 119 patients with uterine adenomyosis, who underwent UAE, were retrospectively evaluated. Each lesion was classified based on its location and morphology on MRI. Thickness and signal intensity were measured in each adenomyosis and in the rectus muscle on the T2-weighted sagittal plane, and the T2-weighted signal intensity ratio (T2SR) was calculated. MR parameters were then compared in patients showing complete response that achieved complete necrosis and incomplete response after UAE via univariate and multivariate analysis. Receiver operating characteristic (ROC) analysis was used to evaluate the diagnostic performance of the predictor using MR parameters for differentiating the complete from the incomplete response.
  
  
  RESULTS
  The complete necrosis rate was 66.4 % (79/119) after UAE for adenomyosis. Univariate and multivariate analysis results indicated that T2SR was associated significantly with complete necrosis (P = 0.012). Symptomatic adenomyosis with T2SR above 0.475 was associated with complete necrosis after UAE (sensitivity = 57.0, specificity = 70.0, area under the ROC curve [AUC] = 0.643).
  
  
  CONCLUSIONS
  T2SR of adenomyosis on pre-procedural MRI can be utilised as a predictor for early therapeutic response of UAE in adenomyosis.
authors.affiliation: Department of Radiology and Research Institute of Radiological Science, Severance Hospital, Yonsei University College of Medicine, 50 Yonsei-ro, Seodaemun-gu, Seoul 120-752, Republic of Korea.
authors.forename: Dae Chul
authors.initials: DC
authors.lastname: Jung
authors.forename: Man Deuk
authors.initials: MD
authors.lastname: Kim
authors.forename: Young Taik
authors.initials: YT
authors.lastname: Oh
authors.forename: Jong Yun
authors.initials: JY
authors.lastname: Won
authors.forename: Do Yun
authors.initials: DY
authors.lastname: Lee
mesh_terms: D062788:Adenomyosis / Q000473:pathology* / Q000628:therapy*; D000328:Adult; D042241:Early Diagnosis; D005260:Female; D006490:Hemostatics / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D011142:Polyvinyl Alcohol / Q000627:therapeutic use*; D011379:Prognosis; D016896:Treatment Outcome; D055357:Uterine Artery Embolization / Q000379:methods*
chemical_list: D006490:Hemostatics; D011142:Polyvinyl Alcohol