title: The presence of overactive bladder wet increased the risk and severity of erectile dysfunction in men with type 2 diabetes.
abstract: BACKGROUND
  Diabetes is a common risk factor for overactive bladder (OAB) syndrome and erectile dysfunction (ED).
  
  
  OBJECTIVE
  The study evaluated the risk factors of OAB and association of OAB and ED in type 2 diabetic men.
  
  
  METHODS
  The diagnosis of ED and OAB was based on a self-administered questionnaire containing Sexual Health Inventory for Men (SHIM) and OAB symptom score (OABSS, 0-15, indicating increasing severity of symptoms), respectively.
  
  
  METHODS
  The clinical variables and diabetes-associated complications, including ED, which are risk factors for OAB, were evaluated.
  
  
  RESULTS
  Of 453 consecutive subjects attending outpatient diabetic clinic with a mean age of 60.6 years, 25.4%, 10.2%, 81.9%, and 28.3% reported having OAB, OAB wet, ED, and severe ED, respectively. The OABSS is inversely associated with SHIM (correlation coefficient-0.275). The patients with OAB have significantly lower SHIM score, testosterone level, and serum albumin level, have more proportion of severe ED, were older, and have longer duration of diabetes mellitus (DM). After adjustment for age and duration of DM, the presence of severe ED was associated with OAB (odds ratio [OR] = 1.58), and severe ED (OR = 2.36), SHIM score (OR = 0.92), and serum albumin level (OR = 0.24) were risk factors for OAB wet (patients with urgency incontinence, once a week or more). The OR of ED in patients with OAB or OAB wet compared with no OAB was 1.82, and 3.61, respectively. Among the OAB components, urgency incontinence has the strongest impact on ED (OR = 4.06), followed by nocturia, urgency, and frequency. About 15.1% (N = 68) without OAB and ED are younger and have shorter DM duration, lower systolic BP, and higher serum albumin level after multivariate analysis compared with patients with OAB or ED.
  
  
  CONCLUSIONS
  The presence of severe ED was significantly associated with OAB, especially OAB wet. The presence of OAB wet increased the risk and severity of ED.
authors.affiliation: Division of Metabolism, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Taiwan.
authors.forename: Rue-Tsuan
authors.initials: RT
authors.lastname: Liu
authors.forename: Min-Shen
authors.initials: MS
authors.lastname: Chung
authors.forename: Yao-Chi
authors.initials: YC
authors.lastname: Chuang
authors.forename: Jong-Jer
authors.initials: JJ
authors.lastname: Lee
authors.forename: Wei-Chia
authors.initials: WC
authors.lastname: Lee
authors.forename: Hsueh-Wen
authors.initials: HW
authors.lastname: Chang
authors.forename: Kuender D
authors.initials: KD
authors.lastname: Yang
authors.forename: Michael B
authors.initials: MB
authors.lastname: Chancellor
mesh_terms: D000368:Aged; D002097:C-Reactive Protein / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D003404:Creatinine / Q000097:blood; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000150:complications*; D007172:Erectile Dysfunction / Q000097:blood / Q000209:etiology*; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012709:Serum Albumin / Q000032:analysis; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000097:blood; D053201:Urinary Bladder, Overactive / Q000097:blood / Q000209:etiology*
chemical_list: D002097:C-Reactive Protein; D002784:Cholesterol; D003404:Creatinine; D006442:Glycated Hemoglobin; D012709:Serum Albumin; D014280:Triglycerides; D014527:Uric Acid; C517652:hemoglobin A1c protein, human