title: Loudness dependence of auditory evoked potentials in patients with borderline personality disorder--impact of psychopathology.
abstract: Alterations of the central serotonergic system are considered to be involved in the pathophysiology of borderline personality disorder (BPD). The loudness dependence of the N1/P2 component of auditory evoked potentials (LD) has been shown to indirectly reflect central serotonergic activity. The aim of this study was to investigate LD in patients with BPD compared to healthy controls, and to evaluate the association between LD and psychopathology such as anxiety, anger or impulsiveness. Female patients with BPD were included and compared to age- and sex-matched healthy subjects. Self-rating instruments, such as the State-Trait Anxiety Inventory (STAI), State-Trait Anger Expression Inventory (STAXI), and the Barratt Impulsiveness Scale (BIS) were used to assess clinical scores of anxiety, anger, and impulsiveness. Evoked potentials were recorded following the application of acoustic stimuli with increasing intensities; the LD was analysed using dipole source analysis. The mean LD was significantly higher in patients with BPD compared to controls. In the entire sample there were significant positive correlations of LD with state anxiety scores and STAXI subscores. The data contribute to the knowledge of neurophysiological alterations in patients with BPD, supporting the hypothesis of serotonergic dysregulation in the pathophysiology of the disorder. The significant clinical correlations suggest monoaminergic modulations of psychopathology on the symptom level.
authors.affiliation: Department of Psychiatry, Ludwig-Maximilian-University of Munich, Germany.
authors.forename: Nadine
authors.initials: N
authors.lastname: Schaaff
authors.forename: Susanne
authors.initials: S
authors.lastname: Karch
authors.forename: Felix
authors.initials: F
authors.lastname: Segmiller
authors.forename: Walter
authors.initials: W
authors.lastname: Koch
authors.forename: Markus
authors.initials: M
authors.lastname: Reicherzer
authors.forename: Christoph
authors.initials: C
authors.lastname: Mulert
authors.forename: Ulrich
authors.initials: U
authors.lastname: Hegerl
authors.forename: Georg
authors.initials: G
authors.lastname: Juckel
authors.forename: Oliver
authors.initials: O
authors.lastname: Pogarell
mesh_terms: D000161:Acoustic Stimulation / Q000379:methods*; D000293:Adolescent; D000328:Adult; D000786:Anger / Q000502:physiology; D001007:Anxiety / Q000503:physiopathology / Q000523:psychology; D001883:Borderline Personality Disorder / Q000503:physiopathology* / Q000523:psychology; D002540:Cerebral Cortex / Q000503:physiopathology*; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D007175:Impulsive Behavior / Q000503:physiopathology / Q000523:psychology; D057566:Self Report