title: Management of granulomatous common variable immunodeficiency diagnosed in pregnancy: a case report.
abstract: Common variable immunodeficiency (CVID) is a rare condition that affects women of childbearing age with important implications in pregnancy. It is characterised by low immunoglobulins (Igs), poor antibody response and a susceptibility to recurrent infections. The cornerstone of management of CVID is Ig replacement. As the transfer of IgG across the placenta in the third trimester of pregnancy is necessary for protection of the infant in the first months of life, failure to recognise this condition and treat it appropriately can have adverse consequences for the neonate, as well as the mother. Here we describe the complex perinatal medical management of a 34-year-old woman who was diagnosed with CVID in the 26th week of pregnancy.
authors.affiliation: Department of Clinical Immunology, St Mary's Hospital, Imperial College Healthcare NHS Trust, London, UK. a.manson@doctors.org.uk
authors.forename: A L
authors.initials: AL
authors.lastname: Manson
authors.forename: S
authors.initials: S
authors.lastname: Zaheri
authors.forename: P
authors.initials: P
authors.lastname: Kelleher
authors.forename: S
authors.initials: S
authors.lastname: Wakelin
authors.forename: C
authors.initials: C
authors.lastname: Nelson-Piercy
authors.forename: S L
authors.initials: SL
authors.lastname: Seneviratne
authors.forename: N
authors.initials: N
authors.lastname: Cooper
mesh_terms: D002585:Cesarean Section; D003131:Combined Modality Therapy; D017074:Common Variable Immunodeficiency / Q000175:diagnosis* / Q000628:therapy*; D019468:Disease Management; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D010298:Parity; D011181:Postnatal Care / Q000379:methods*; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000175:diagnosis* / Q000628:therapy; D035583:Rare Diseases