title: Primary coronary artery bypass surgery in the presence of decreasing preoperative renal function: effect on short-term outcomes.
abstract: BACKGROUND
  This study evaluated the impact of decreasing renal function on short-term outcomes in patients undergoing primary coronary artery bypass grafting (CABG).
  
  
  METHODS
  The study period was from February 1999 to February 2009. Data on 4050 patients undergoing primary CABG were prospectively collected and analyzed retrospectively. The study population was divided into 3 groups: the CABG:N group, patients with preoperative serum creatinine levels <2 mg/dL (n = 3947); the CABG:RF group, patients with preoperative creatinine levels >2 mg/dL (n = 87); and the CABG:D group, patients on dialysis (n = 16).
  
  
  RESULTS
  The significant differences between the groups (CABG:D > CABG:RF > CABG:N) in short-term outcomes were with respect to blood product use (P < .001), postoperative acute myocardial infarction (P < .001), pulmonary complications (P .001), infection (P < .001), and death (P < .001). The risk of short-term death (30 days) in the CABG:D group (4/16, 25%) was 25 times greater than that in the CABG:N group (38/3947, 0.96%).
  
  
  CONCLUSIONS
  CABG in the presence of renal failure is associated with significant morbidity and mortality.
authors.affiliation: Department of Cardiothoracic Surgery, Princess Alexandra Hospital, Brisbane, Australia.
authors.forename: Hasanga
authors.initials: H
authors.lastname: Jayasekera
authors.forename: Ryan
authors.initials: R
authors.lastname: Harvey
authors.forename: Nigel
authors.initials: N
authors.lastname: Pinto
authors.forename: Julie
authors.initials: J
authors.lastname: Mundy
authors.forename: Annabel
authors.initials: A
authors.lastname: Wood
authors.forename: Elaine
authors.initials: E
authors.lastname: Beller
authors.forename: Paul
authors.initials: P
authors.lastname: Peters
authors.forename: Pallav
authors.initials: P
authors.lastname: Shah
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D015897:Comorbidity; D001026:Coronary Artery Bypass / Q000401:mortality*; D003324:Coronary Artery Disease / Q000401:mortality* / Q000601:surgery*; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D007677:Kidney Function Tests / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D057234:Preoperative Period; D015995:Prevalence; D051437:Renal Insufficiency / Q000097:blood / Q000175:diagnosis* / Q000401:mortality*; D018570:Risk Assessment; D012307:Risk Factors; D016019:Survival Analysis; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D003404:Creatinine