title: Multimodality imaging in amyloidosis.
abstract: Amyloidosis comprises a rare spectrum of protein deposition diseases that diffusely or focally affect any organ. Amyloid's variable clinical presentation and nonspecific disease course often cause it to evade early diagnosis. This pictorial essay aims to familiarize radiologists with the pathophysiology of amyloidosis, to describe the basic classifications of amyloidosis, and to use multimodality imaging to illustrate its varied appearance throughout the body. This review highlights the diagnostic challenge of interpreting radiographic studies in patients with hematologic malignancies and concurrent amyloidosis. Radiologists should consider amyloid in chronically ill patients or patients with hematologic malignancies who have unusual/unexpected imaging findings.
authors.affiliation: Department of Radiology, Dana Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02115, USA. sahoward@partners.org
authors.forename: Stephanie
authors.initials: S
authors.lastname: Howard
authors.forename: Jyothi
authors.initials: J
authors.lastname: Jagannathan
authors.forename: Katherine
authors.initials: K
authors.lastname: Krajewski
authors.forename: Angela
authors.initials: A
authors.lastname: Giardino
authors.forename: Katherine
authors.initials: K
authors.lastname: Zukotynski
authors.forename: Kevin
authors.initials: K
authors.lastname: O'Regan
authors.forename: Irene
authors.initials: I
authors.lastname: Ghobrial
authors.forename: Nikhil
authors.initials: N
authors.lastname: Ramaiya
mesh_terms: D000686:Amyloidosis / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D003952:Diagnostic Imaging / Q000379:methods*; D004452:Echocardiography; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D005471:Fluoroscopy; D006321:Heart / Q000000981:diagnostic imaging; D019337:Hematologic Neoplasms / Q000150:complications; D006801:Humans; D007249:Inflammation / Q000150:complications; D007596:Joints / Q000000981:diagnostic imaging / Q000473:pathology; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D008279:Magnetic Resonance Imaging / Q000379:methods; D064847:Multimodal Imaging / Q000379:methods; D009206:Myocardium / Q000473:pathology; D049268:Positron-Emission Tomography; D019275:Radiopharmaceuticals; D014057:Tomography, X-Ray Computed / Q000379:methods; D014781:Viscera / Q000000981:diagnostic imaging
chemical_list: D005462:Fluorine Radioisotopes; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18