title: Bioactive polymer scaffold for fabrication of vascularized engineering tissue.
abstract: Tissue engineering seeks strategies to design polymeric scaffolds that allow high-cell-density cultures with signaling molecules and suitable vascular supply. One major obstacle in tissue engineering is the inability to create thick engineered-tissue constructs. A pre-vascularized tissue scaffold appears to be the most favorable approach to avoid nutrient and oxygen supply limitations as well as to allow waste removal, factors that are often hurdles in developing thick engineered tissues. Vascularization can be achieved using strategies in which cells are cultured in bioactive polymer scaffolds that can mimic extracellular matrix environments. This review addresses recent advances and future challenges in developing and using bioactive polymer scaffolds to promote tissue construct vascularization.
authors.affiliation: Medical Devices and Implant Technology (Mediteg) Research Group, Department of Biomechanics and Biomedical Materials, Universiti Teknologi Malaysia, Block P23 UTM Skudai, 81310 Johor Bahru, Johore, Malaysia. Irza.Sukmana@gmail.com
authors.forename: Irza
authors.initials: I
authors.lastname: Sukmana
mesh_terms: D042783:Endothelial Cells / Q000502:physiology; D005109:Extracellular Matrix / Q000502:physiology; D006801:Humans; D018919:Neovascularization, Physiologic / Q000502:physiology*; D011108:Polymers; D023822:Tissue Engineering; D054457:Tissue Scaffolds
chemical_list: D011108:Polymers