title: Bronchial thermoplasty.
abstract: Even with the use of maximum pharmacological treatment, asthma still remains uncontrolled in some cases. For such cases of uncontrolled asthma, a novel therapy--Bronchial Thermoplasty (BT)--has shown some promising results over the past few years. BT is application of controlled radiofrequency heat via catheter inserted through a flexible bronchoscope, to the bronchial walls. It reduces the smooth muscle mass in bronchial wall and thus results in decreased contractility. Three major trials of BT show that it does not cause any improvement in FEV1. However, BT causes improvement the quality of life and decreases the future exacerbations and emergency hospital visits due to asthma. But the benefit observed was too small to be clinically significant. Follow up (two to five years) results of these BT trials did not show any significant long-term adverse event related to BT. However, further independent large randomized controlled trials and results of application of BT in real hospital settings are needed to define its role in asthma management.
authors.affiliation: Department of Pulmonary Medicine, Christian Medical College, Vellore, Tamil Nadu. drprincej@gmail.com
authors.forename: Prince
authors.initials: P
authors.lastname: James
authors.forename: Richa
authors.initials: R
authors.lastname: Gupta
mesh_terms: D000553:Ambulatory Care / Q000379:methods; D018927:Anti-Asthmatic Agents / Q000627:therapeutic use; D001249:Asthma / Q000473:pathology / Q000628:therapy; D001980:Bronchi / Q000473:pathology / Q000528:radiation effects; D001999:Bronchoscopy / Q000379:methods*; D017115:Catheter Ablation / Q000191:economics / Q000379:methods*; D002986:Clinical Trials as Topic; D003365:Costs and Cost Analysis; D004351:Drug Resistance; D006801:Humans; D009130:Muscle, Smooth / Q000473:pathology / Q000528:radiation effects; D012129:Respiratory Function Tests / Q000379:methods; D016896:Treatment Outcome
chemical_list: D018927:Anti-Asthmatic Agents