title: [Type 1 diabetes mellitus, diabetic nephropathy: transplantology potential].
abstract: The review covers the role of transplantology in treatment of patients with type 1 diabetes and the state of its development in the world and in Russia. The results of major multicenter studies, devoted to the influence of simultaneous kidney and pancreas transplantation and kidney transplantation alone on life expectancy and quality of life of diabetic patients are summarized here. Experience in pancreas-kidney transplantation, gained in Academician VI. Shumakov Federal Research Center of Transplantology and Artificial Organs, is described, including surgical technical and postoperative treatment. Also we perform the results of research work, devoted to the influence of pancreas transplantation on dfferent homeostasis parameters, such as: oxidative stress parameters, homocysteine, receptor for advanced glycation endproduct (RAGE), and markers ofendocrine function of pancreas transplant.
authors.forename: S V
authors.initials: SV
authors.lastname: Got'e
mesh_terms: D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D003928:Diabetic Nephropathies / Q000209:etiology / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D006085:Graft Survival; D006706:Homeostasis; D006801:Humans; D007668:Kidney / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D016030:Kidney Transplantation / Q000009:adverse effects / Q000379:methods; D008017:Life Expectancy; D010043:Outcome and Process Assessment, Health Care; D010179:Pancreas / Q000378:metabolism / Q000473:pathology / Q000601:surgery*; D016035:Pancreas Transplantation / Q000009:adverse effects / Q000379:methods; D011184:Postoperative Period; D010818:Practice Patterns, Physicians'; D011788:Quality of Life