title: ZFP36 expression impairs glioblastoma cell lines viability and invasiveness by targeting multiple signal transduction pathways.
abstract: RNA binding proteins belonging to the TIS11/TTP gene family regulate the stability of multiple targets. Their inactivation or deregulated expression has recently been related to cancer, and it has been suggested that they are capable of displaying tumor suppressor activities. Here we describe three new targets of ZFP36 (PIM-1, PIM-3 and XIAP) and show by different approaches that its ectopic expression is capable of impairing glioblastoma cell lines viability and invasiveness by interfering with different transduction pathways. Moreover, we provide evidence that compounds capable of inducing the expression of TIS11/TTP genes determine a comparable biological effect on the same cell contexts.
authors.affiliation: Dipartimento di Scienze Biomediche, Sezione di Chimica Biologica, Università di Modena e Reggio Emilia, Modena, Italy.
authors.forename: Tommaso
authors.initials: T
authors.lastname: Selmi
authors.forename: Andrea
authors.initials: A
authors.lastname: Martello
authors.forename: Tatiana
authors.initials: T
authors.lastname: Vignudelli
authors.forename: Erika
authors.initials: E
authors.lastname: Ferrari
authors.forename: Alexis
authors.initials: A
authors.lastname: Grande
authors.forename: Claudia
authors.initials: C
authors.lastname: Gemelli
authors.forename: Paolo
authors.initials: P
authors.lastname: Salomoni
authors.forename: Sergio
authors.initials: S
authors.lastname: Ferrari
authors.forename: Tommaso
authors.initials: T
authors.lastname: Zanocco-Marani
mesh_terms: D020413:3' Untranslated Regions; D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D002465:Cell Movement; D002470:Cell Survival; D005656:Fungal Proteins; D005909:Glioblastoma / Q000378:metabolism / Q000473:pathology; D057809:HEK293 Cells; D006801:Humans; D020928:Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D059808:Polyphenols / Q000494:pharmacology; D011485:Protein Binding; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism; D034622:RNA Interference; D034741:RNA, Small Interfering / Q000378:metabolism; D015398:Signal Transduction; D051816:Tristetraprolin / Q000235:genetics / Q000378:metabolism*; D051636:X-Linked Inhibitor of Apoptosis Protein / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism
chemical_list: D020413:3' Untranslated Regions; D005656:Fungal Proteins; D059808:Polyphenols; D011518:Proto-Oncogene Proteins; D034741:RNA, Small Interfering; D051816:Tristetraprolin; D051636:X-Linked Inhibitor of Apoptosis Protein; C497552:ZFP36 protein, human; C499249:PIM3 protein, human; D017346:Protein Serine-Threonine Kinases; D020928:Mitogen-Activated Protein Kinases; C432694:Pim1 protein, Pichia pastoris