title: Age of 40 years or younger is an independent risk factor for locoregional failure in early breast cancer: a single-institutional analysis in saudi arabia.
abstract: Background. This study was undertaken to evaluate the impact of prognostic factors on the locoregional failure-free survival of early breast cancer patients. Methods. In this single-institutional study, 213 breast cancer patients were retrospectively analysed. Fifty-five of 213 patients were ≤40 years of age at diagnosis. The impact of patient- or treatment-related factors on the locoregional failure-free survival was assessed using the Kaplan-Meier method. The simultaneous impact of factors on the locoregional failure-free survival was assessed using the Cox proportional hazards regression analysis. Results. The median follow-up time of the censored patients was 22 months (mean 28 months, range 3-92 months). On univariate analysis, statistically significant factors for the locoregional failure-free survival were the age (≤40 versus >40 years), T stage (Tis, T0-2 versus T3-4), molecular tumor type (luminal A versus luminal B, Her2neu overexpression, or triple negative), and lymphovascular status (LV0 versus LV1). On multivariate analysis, age and T stage remained statistically significant. Conclusions. Being 40 years or younger has a statistically significant independent adverse impact on the locoregional failure-free survival of patients with early breast cancer.
authors.affiliation: Department of Radiation Oncology, Saad Specialist Hospital, P.O. Box 30353, Al Khobar 31952, Saudi Arabia.
authors.forename: Volker
authors.initials: V
authors.lastname: Rudat
authors.forename: Hamdan
authors.initials: H
authors.lastname: El-Sweilmeen
authors.forename: Elias
authors.initials: E
authors.lastname: Fadel
authors.forename: Iris
authors.initials: I
authors.lastname: Brune-Erber
authors.forename: Alaa
authors.initials: A
authors.lastname: Ahmad Nour
authors.forename: Zinaida
authors.initials: Z
authors.lastname: Bushnag
authors.forename: Nidal
authors.initials: N
authors.lastname: Masri
authors.forename: Saleh
authors.initials: S
authors.lastname: Altuwaijri