title: [Clinical analysis of invasive fungal infections in patients with hematologic malignancies].
abstract: The aim of this study was to investigate the clinical situation of invasive fungal infections in patients with hematological malignancies, and discuss the susceptible factors and precautions. 541 patients with hematological malignancies from 2008 Jan to 2011 Dec in hospital 307 of Chinese PLA were statistically retrospectively analyzed in term of clinical manifestation, image examination, culture results of secretions, therapy and so on. The results showed that 63 out of 541 patients got invasive fungal infections. The respiratory tract and intestinal tract were the most common infection sites (62.34 and 19.48, respectively); Candida albicans (66.67) and Candida glabrata (12.82) were the most common pathogens. It is concluded that the main risk factors are as follows: primary diseases, chemotherapy, glucocorticoid, leukopenia after chemotherapy, applications of broad-spectrum antibiotics and aging. It is suggested that a stratification of risk factors is helpful in preventing and treating invasive fungal infections.
authors.affiliation: General Hospital of PLA, Beijing, China.
authors.forename: Sha
authors.initials: S
authors.lastname: Liu
authors.forename: Mei
authors.initials: M
authors.lastname: Guo
authors.forename: Jian-Hui
authors.initials: JH
authors.lastname: Qiao
authors.forename: Chang-Lin
authors.initials: CL
authors.lastname: Yu
authors.forename: Qi-Yun
authors.initials: QY
authors.lastname: Sun
authors.forename: Kai-Xun
authors.initials: KX
authors.lastname: Hu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002175:Candida / Q000472:pathogenicity; D002648:Child; D003428:Cross Infection / Q000382:microbiology*; D005260:Female; D019337:Hematologic Neoplasms / Q000150:complications / Q000382:microbiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000150:complications / Q000382:microbiology; D012189:Retrospective Studies; D055815:Young Adult