title: A functional polymorphism in the promoter region of the IL1B gene is associated with risk of multiple myeloma.
abstract: The cytokine interleukin-1β (IL1B) is important for anti-tumour immune response. Genetic variation may modify the expression of IL1B and thereby influence the risk of disease. We investigated genetic variations with functional importance in the IL1B and NFKB1 genes in 348 population-based samples of multiple myeloma (MM) and a random sample of 1700 individuals. Carriers of the variant T-allele IL1B C-3737T and carriers of the TGT haplotype were at lower risk of MM [relative risk (RR) 0·58 (95% confidence interval (CI) = 0·41-0·84) and RR 0·59 (95%CI 0·40-0·85), respectively]. No association with risk of MM was found for the NFKB1- 94 ins/del polymorphism.
authors.affiliation: Department of Haematology, Roskilde Hospital, Copenhagen University, Roskilde, Denmark. avag@regionsjaelland.dk
authors.forename: Annette J
authors.initials: AJ
authors.lastname: Vangsted
authors.forename: Kaspar R
authors.initials: KR
authors.lastname: Nielsen
authors.forename: Tobias W
authors.initials: TW
authors.lastname: Klausen
authors.forename: Einar
authors.initials: E
authors.lastname: Haukaas
authors.forename: Anne
authors.initials: A
authors.lastname: Tjønneland
authors.forename: Ulla
authors.initials: U
authors.lastname: Vogel
mesh_terms: D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D053583:Interleukin-1beta / Q000235:genetics*; D008297:Male; D009101:Multiple Myeloma / Q000235:genetics* / Q000276:immunology; D052002:NF-kappa B p50 Subunit / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics*
chemical_list: D053583:Interleukin-1beta; D052002:NF-kappa B p50 Subunit; C489548:NFKB1 protein, human