title: [Metabolic immunocorrection treatment of experimental widespread purulent peritonitis].
abstract: The effect of citoflavin and neoton preparations on the migration activity of neutrophil granulocytes under action of mitogen-induced immunocompetent blood cells, Peyer's patches, spleen and inguinal lymph was studied on a group of 55 male chinchilla rabbits with experimental model of widespread purulent peritonitis. It is established that the regulating action of immunocompetent cells on the migration of neutrophil leukocytes under the conditions of widespread purulent peritonitis is stable and widespread process, which is observed within 5 days of the postoperative period. The use of citoflavin and neoton during the postoperative period produces correction of the activity of immunocompetent cells, changing their properties in regulation of the migratory activity of neutrophil granulocytes. The effect is characteristic of both preparations and it is observed in all investigated organs, being manifested to a greater degree in immunocompetent cells of peripheral blood and Peyer's patches. Metabolic preparation citoflavin exhibits a more pronounced immunotropic action in comparison to neoton, which contains creatine phosphate.
authors.forename: V K
authors.initials: VK
authors.lastname: Gostishchev
authors.forename: V A
authors.initials: VA
authors.lastname: Kosinets
authors.forename: E A
authors.initials: EA
authors.lastname: Matusevich
authors.forename: G P
authors.initials: GP
authors.lastname: Adamenko
mesh_terms: D000818:Animals; D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D002465:Cell Movement / Q000187:drug effects* / Q000276:immunology; D004195:Disease Models, Animal; D004338:Drug Combinations; D004926:Escherichia coli / Q000276:immunology; D005486:Flavin Mononucleotide / Q000008:administration & dosage* / Q000627:therapeutic use; D006119:Groin; D006801:Humans; D007290:Inosine Diphosphate / Q000008:administration & dosage* / Q000627:therapeutic use; D008198:Lymph Nodes / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D008297:Male; D009000:Monocytes / Q000187:drug effects / Q000276:immunology; D018696:Neuroprotective Agents / Q000008:administration & dosage / Q000627:therapeutic use; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology; D009536:Niacinamide / Q000008:administration & dosage* / Q000627:therapeutic use; D010538:Peritonitis / Q000188:drug therapy* / Q000276:immunology* / Q000382:microbiology; D010581:Peyer's Patches / Q000187:drug effects* / Q000276:immunology; D010725:Phosphocreatine / Q000008:administration & dosage / Q000627:therapeutic use; D011184:Postoperative Period; D011817:Rabbits; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000276:immunology*; D013386:Succinates / Q000008:administration & dosage* / Q000627:therapeutic use; D013492:Suppuration
chemical_list: D002316:Cardiotonic Agents; D004338:Drug Combinations; D018696:Neuroprotective Agents; D013386:Succinates; C507879:cytoflavin; D010725:Phosphocreatine; D009536:Niacinamide; D005486:Flavin Mononucleotide; D007290:Inosine Diphosphate