title: Synthesis of variously sulfated biotinylated oligosaccharides from the linkage region of proteoglycans.
abstract: The synthesis of a collection, as biotinylated conjugates, of various sulfoforms of the trisaccharide β-D-GlcpA-(1→3)-β-D-Galp-(1→3)-β-D-Galp, structures encountered in the linkage region of proteoglycans, is reported herein for the first time. An efficient and stereocontrolled preparation was achieved using common key intermediates in a divergent manner. These molecules should be useful probes to study the substrate specificity of the glycosyltransferases involved at the bifurcation point in the biosynthesis of proteoglycans.
authors.affiliation: Institut de Chimie Organique et Analytique, UMR 7311 CNRS et Université d'Orléans, Pôle de Chimie, Université d'Orléans, BP 6759, 45067 Orléans Cedex 2, France.
authors.forename: Katia
authors.initials: K
authors.lastname: Aït-Mohand
authors.forename: Chrystel
authors.initials: C
authors.lastname: Lopin-Bon
authors.forename: Jean-Claude
authors.initials: JC
authors.lastname: Jacquinet
mesh_terms: D002240:Carbohydrate Sequence; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000737:chemistry*; D011509:Proteoglycans / Q000737:chemistry*
chemical_list: D009844:Oligosaccharides; D011509:Proteoglycans