title: Characterization of human papillomavirus type 120: a novel betapapillomavirus with tropism for multiple anatomical niches.
abstract: Recent studies indicate that human papillomaviruses (HPVs) from the genera Betapapillomavirus and Gammapapillomavirus are abundant in the human oral cavity. We report the cloning and characterization of a 7304 bp HPV120 genome from the oral cavity that is related most closely to HPV23 (L1 ORF, 83.7 % similarity), clustering it in the genus Betapapillomavirus (β-PV). HPV120 contains five early and two late genes, but no E5 ORF. HPV120 was detected from heterogeneous human biological niches, including the oral cavity, eyebrow hairs, anal canal and penile, vulvar and perianal warts. Characterization of the clinical spectrum of HPV120 infections indicates a broader spectrum of epithelial tropism than appreciated previously for HPV types from the genus β-PV.
authors.affiliation: Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
authors.forename: Danielle
authors.initials: D
authors.lastname: Bottalico
authors.affiliation: Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
authors.forename: Zigui
authors.initials: Z
authors.lastname: Chen
authors.affiliation: Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Zaloška 4, 1105 Ljubljana, Slovenia.
authors.forename: Boštjan J
authors.initials: BJ
authors.lastname: Kocjan
authors.affiliation: Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Zaloška 4, 1105 Ljubljana, Slovenia.
authors.forename: Katja
authors.initials: K
authors.lastname: Seme
authors.affiliation: Institute of Microbiology and Immunology, Faculty of Medicine, University of Ljubljana, Zaloška 4, 1105 Ljubljana, Slovenia.
authors.forename: Mario
authors.initials: M
authors.lastname: Poljak
authors.affiliation: Obstetrics, Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA.|Departments of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.|Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY 10461, USA.|Department of Pediatrics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
authors.forename: Robert D
authors.initials: RD
authors.lastname: Burk
mesh_terms: D001003:Anal Canal / Q000821:virology; D052686:Betapapillomavirus / Q000145:classification* / Q000235:genetics*; D003218:Condylomata Acuminata / Q000821:virology; D015967:Gene Expression Regulation, Viral; D016679:Genome, Viral; D006197:Hair / Q000821:virology; D006801:Humans; D008969:Molecular Sequence Data; D009055:Mouth / Q000821:virology; D030361:Papillomavirus Infections / Q000821:virology; D010802:Phylogeny; D020641:Polymorphism, Single Nucleotide; D056189:Viral Tropism / Q000502:physiology*