title: Comparison of the host immune response to herpes simplex virus 1 (HSV-1) and HSV-2 at two different mucosal sites.
abstract: A study was undertaken to compare the host immune responses to herpes simplex virus 1 (HSV-1) and HSV-2 infection by the ocular or genital route in mice. Titers of HSV-2 from tissue samples were elevated regardless of the route of infection. The elevation in titers of HSV-2, including cell infiltration and cytokine/chemokine levels in the central nervous system relative to those found following HSV-1 infection, was correlative with inflammation. These results underscore a dichotomy between the host immune responses to closely related alphaherpesviruses.
authors.affiliation: Department of Ophthalmology, The University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA.
authors.forename: Min
authors.initials: M
authors.lastname: Zheng
authors.forename: Christopher D
authors.initials: CD
authors.lastname: Conrady
authors.forename: Julie M
authors.initials: JM
authors.lastname: Ward
authors.forename: Katie M
authors.initials: KM
authors.lastname: Bryant-Hudson
authors.forename: Daniel J J
authors.initials: DJ
authors.lastname: Carr
mesh_terms: D000818:Animals; D016207:Cytokines / Q000378:metabolism; D005260:Female; D018259:Herpesvirus 1, Human / Q000276:immunology*; D018258:Herpesvirus 2, Human / Q000276:immunology*; D018928:Immunity, Mucosal; D051379:Mice; D008810:Mice, Inbred C57BL; D019562:Viral Load
chemical_list: D016207:Cytokines