title: Neural basis of autobiographical memory retrieval in schizophrenia.
abstract: BACKGROUND
  Autobiographical memory retrieval is impaired in schizophrenia.
  
  
  OBJECTIVE
  To determine the neural basis of this impairment.
  
  
  METHODS
  Thirteen patients with schizophrenia and 14 healthy controls performed an autobiographical memory retrieval task based on cue words during functional magnetic resonance imaging. Patients were selected on the basis of their ability to perform the task and all participants received training.
  
  
  RESULTS
  Although patients and controls activated a similar brain network during autobiographical memory retrieval, patients displayed decreased activation in several of these regions, including the anterior cingulate cortex, left lateral prefrontal cortex, right cerebellum and ventral tegmental area (k≥10, P<0.001, uncorrected). In addition, activation of the caudate nuclei was negatively correlated with retrieval performance in controls but positively correlated with performance in patients.
  
  
  CONCLUSIONS
  The autobiographical memory retrieval brain network is impaired in schizophrenia. Patients with schizophrenia display decreased activation of the cognitive control network during retrieval, possibly due to aberrant functioning of the dorsal striatum.
authors.affiliation: Department of Psychiatry, Centre Hospitalier Universitaire de Reims, Reims and LCPI Laboratory, Toulouse 2 Le Mirail University, Department of Psychology, Toulouse, France.
authors.forename: Christine
authors.initials: C
authors.lastname: Cuervo-Lombard
authors.forename: Cédric
authors.initials: C
authors.lastname: Lemogne
authors.forename: Fabien
authors.initials: F
authors.lastname: Gierski
authors.forename: Céline
authors.initials: C
authors.lastname: Béra-Potelle
authors.forename: Eric
authors.initials: E
authors.lastname: Tran
authors.forename: Christophe
authors.initials: C
authors.lastname: Portefaix
authors.forename: Arthur
authors.initials: A
authors.lastname: Kaladjian
authors.forename: Laurent
authors.initials: L
authors.lastname: Pierot
authors.forename: Frédéric
authors.initials: F
authors.lastname: Limosin
mesh_terms: D000328:Adult; D001921:Brain / Q000503:physiopathology*; D001927:Brain Diseases / Q000503:physiopathology / Q000523:psychology*; D016022:Case-Control Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D061212:Memory, Episodic; D008606:Mental Processes / Q000502:physiology; D011939:Mental Recall; D011581:Psychological Tests; D012563:Schizophrenia, Paranoid / Q000503:physiopathology / Q000523:psychology*; D012565:Schizophrenic Psychology