title: No association between transmembrane protein-tyrosine phosphatase receptor type C (PTPRC) exon A 77C>G transversion and liver transplant rejection.
abstract: This study was carried out to evaluate the association between 77C>G transversion (rs17612648) in exon A of the PTPRC gene and liver transplant rejection. No significant differences in genotype and allele frequencies of the 77C>G transversion were detected between recipients without rejection (n = 106) and recipients with rejection (n = 104). In conclusion, there was no evidence for the contribution of the 77C>G transversion in susceptibility to liver transplant rejection in a Caucasian population.
authors.affiliation: Department of Hepatobiliary and Transplant Surgery, University Hospital Hamburg-Eppendorf, Germany. h.thude@uke.de
authors.forename: H
authors.initials: H
authors.lastname: Thude
authors.forename: A D
authors.initials: AD
authors.lastname: Schipler
authors.forename: A
authors.initials: A
authors.lastname: Treszl
authors.forename: M
authors.initials: M
authors.lastname: Sterneck
authors.forename: B
authors.initials: B
authors.lastname: Nashan
mesh_terms: D000328:Adult; D000368:Aged; D003596:Cytosine / Q000378:metabolism; D005091:Exons; D005260:Female; D005787:Gene Frequency; D056726:Genetic Association Studies / Q000379:methods; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006084:Graft Rejection / Q000235:genetics* / Q000378:metabolism; D006085:Graft Survival; D006147:Guanine / Q000378:metabolism; D006801:Humans; D017493:Leukocyte Common Antigens / Q000235:genetics*; D016031:Liver Transplantation / Q000009:adverse effects / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D044465:White People / Q000235:genetics
chemical_list: D006147:Guanine; D003596:Cytosine; D017493:Leukocyte Common Antigens; C516769:PTPRC protein, human