title: Neutrophil recruitment is inhibited by nicotinamide in experimental pleurisy in mice.
abstract: Several emerging lines of evidence support an anti-inflammatory role for nicotinamide and other vitamin B components. However, the mechanisms underlying their activity remain unclear. In the present study, we investigated the ability of nicotinamide to inhibit both neutrophil recruitment in IL-8-, LTB(4)- or carrageenan-induced pleurisy in mice and the rolling and adherence of neutrophils. Nicotinamide inhibited IL-8-, LTB(4)- and carrageenan-induced neutrophil migration, KC production and carrageenan-induced neutrophil rolling and adherence. We propose that the effects of nicotinamide in inhibiting neutrophil recruitment in carrageenan-induced pleurisy may be due to the ability of nicotinamide to inhibit the action of IL-8 and LTB(4), decrease KC production, and inhibit early events that regulate leukocyte migration from blood vessels into tissue.
authors.affiliation: Laboratório de Inflamação e Dor - Instituto de Ciências Biológicas, UFMG, Brazil.
authors.forename: Raphael G
authors.initials: RG
authors.lastname: Ferreira
authors.forename: Tamires C
authors.initials: TC
authors.lastname: Matsui
authors.forename: Adriana M
authors.initials: AM
authors.lastname: Godin
authors.forename: Lindisley F
authors.initials: LF
authors.lastname: Gomides
authors.forename: Pedro E M
authors.initials: PE
authors.lastname: Pereira-Silva
authors.forename: Igor D G
authors.initials: ID
authors.lastname: Duarte
authors.forename: Gustavo B
authors.initials: GB
authors.lastname: Menezes
authors.forename: Márcio M
authors.initials: MM
authors.lastname: Coelho
authors.forename: André
authors.initials: A
authors.lastname: Klein
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002351:Carrageenan / Q000494:pharmacology; D002448:Cell Adhesion / Q000187:drug effects; D004195:Disease Models, Animal; D016209:Interleukin-8 / Q000494:pharmacology; D036904:Leukocyte Rolling / Q000187:drug effects; D007975:Leukotriene B4 / Q000494:pharmacology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D020556:Neutrophil Infiltration / Q000187:drug effects*; D009536:Niacinamide / Q000494:pharmacology*; D010998:Pleurisy / Q000188:drug therapy* / Q000276:immunology
chemical_list: D000893:Anti-Inflammatory Agents; D016209:Interleukin-8; D007975:Leukotriene B4; D009536:Niacinamide; D002351:Carrageenan