title: Methotrexate induced lung injury in a patient with primary CNS lymphoma: a case report.
abstract: Methotrexate is an antimetabolite commonly used in clinical practice for a variety of indications ranging from rheumatoid arthritis and other connective tissue disorders to high dose regimens in many malignancies. This folate antagonist has got a spectrum of toxicities among which gastrointestinal effects predominate. Lung injury is a well described but rare event and has been reported most often in patients who have been on long term oral therapy for rheumatic disorders. Acute lung injury in a patient receiving a high dose regimen for haematological malignancies has not been reported previously. We present one such case of methotrexate related acute lung injury in a patient of primary CNS lymphoma receiving high dose methotrexate.
authors.affiliation: Department of Internal Medicine, PGIMER Chandigarh 160012, India.
authors.forename: Puneet
authors.initials: P
authors.lastname: Chhabra
authors.forename: Arjun Dutt
authors.initials: AD
authors.lastname: Law
authors.forename: Vikas
authors.initials: V
authors.lastname: Suri
authors.forename: Pankaj
authors.initials: P
authors.lastname: Malhotra
authors.forename: Subhash
authors.initials: S
authors.lastname: Varma