title: Transmitted antiretroviral drug resistance among drug-naive female sex workers with recent infection in Kampala, Uganda.
abstract: During 2006-2007, transmitted human immunodeficiency virus (HIV) drug resistance (TDR) among drug-naive women with newly diagnosed HIV infection and likely to be recently infected when attending antenatal clinics in Entebbe was found to be <5% with use of the World Health Organization (WHO) survey method. Using the same method, we attempted to classify TDR among women who seroconverted during 2008-2010 and who were identified from a cohort of recently infected sex workers in Kampala, Uganda. TDR mutations were identified using the 2009 WHO TDR mutations list. The WHO survey method could not be used to classify TDR because the necessary sample size was not reached during the survey period. However, a point prevalence estimate of 2.6% (95% confidence interval, 0.07%-13.8%) nonnucleoside reverse-transcriptase inhibitor TDR was determined.
authors.affiliation: MRC/UVRI Uganda Research Unit on AIDS, Entebbe, Nigeria.
authors.forename: Deogratius
authors.initials: D
authors.lastname: Ssemwanga
authors.forename: Nicaise
authors.initials: N
authors.lastname: Ndembi
authors.forename: Frederick
authors.initials: F
authors.lastname: Lyagoba
authors.forename: Brian
authors.initials: B
authors.lastname: Magambo
authors.forename: Anne
authors.initials: A
authors.lastname: Kapaata
authors.forename: Justine
authors.initials: J
authors.lastname: Bukenya
authors.forename: George W
authors.initials: GW
authors.lastname: Lubega
authors.forename: Silvia
authors.initials: S
authors.lastname: Bertagnolio
authors.forename: Judith
authors.initials: J
authors.lastname: Vandepitte
authors.forename: Heiner
authors.initials: H
authors.lastname: Grosskurth
authors.forename: Pontiano
authors.initials: P
authors.lastname: Kaleebu
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000494:pharmacology*; D015331:Cohort Studies; D024882:Drug Resistance, Viral; D005260:Female; D006678:HIV / Q000145:classification / Q000187:drug effects* / Q000235:genetics; D006679:HIV Seropositivity / Q000453:epidemiology / Q000635:transmission* / Q000821:virology*; D006801:Humans; D060386:Sex Workers / Q000706:statistics & numerical data*; D011795:Surveys and Questionnaires; D014454:Uganda / Q000453:epidemiology
chemical_list: D019380:Anti-HIV Agents