title: The TBX21 transcription factor T-1993C polymorphism is associated with decreased IFN-γ and IL-4 production by primary human lymphocytes.
abstract: T-bet is a transcription factor that drives the Th1 immune response primarily through promoting expression of the IFN-γ gene. Polymorphisms in the T-bet gene, TBX21, have been associated with immune-mediated diseases such as asthma and systemic sclerosis. We found that the TBX21 promoter polymorphism T-1993C is associated with a significant decrease in IL-4 and IFN-γ production by stimulated primary human lymphocytes from healthy participants.
authors.affiliation: Department of Dermatology, University of North Carolina, Chapel Hill, NC zina@iff.fiocruz.br, USA.
authors.forename: K M
authors.initials: KM
authors.lastname: Fyall
authors.forename: A M
authors.initials: AM
authors.lastname: Fong
authors.forename: S B
authors.initials: SB
authors.lastname: Rao
authors.forename: J G
authors.initials: JG
authors.lastname: Ibrahim
authors.forename: W T
authors.initials: WT
authors.lastname: Waxweiler
authors.forename: N E
authors.initials: NE
authors.lastname: Thomas
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D005786:Gene Expression Regulation / Q000276:immunology; D056726:Genetic Association Studies; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis* / Q000276:immunology; D015847:Interleukin-4 / Q000096:biosynthesis* / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D061251:Primary Cell Culture; D011401:Promoter Regions, Genetic / Q000276:immunology; D020825:T-Box Domain Proteins / Q000235:genetics* / Q000276:immunology; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D000098815:T-bet Transcription Factor
chemical_list: D020825:T-Box Domain Proteins; D000098815:T-bet Transcription Factor; D015847:Interleukin-4; D007371:Interferon-gamma; D013755:Tetradecanoylphorbol Acetate