title: [Childhood's determinants for high blood pressure in adulthood].
abstract: Hypertension has been estimated to affect 20 - 25% of the adult population and represents an important risk factor for cardiovascular disease like coronary heart disease, stroke and peripheral artery occlusive disease. In addition, hypertension supports the development and progression of chronic kidney insufficiency. The interaction of multiple genetic and environmental factors are felt to influence the level of blood pressure. Epidemiological data in the sixties and seventies demonstrated a correlation between cardiovascular disease and infant mortality in the same population. In the late eighties Barker and coworkers described a strong correlation between low birth weight and increased risk for the development of cardiovascular complications. It has been supposed that factors influencing the intrauterine growth and development can lead to adult cardiovascular diseases, known as the concept of "fetal programming". Beside the effect of fetal programming, multiple (preventable and non-preventable) factors determine the blood pressure level in childhood, which will define adult blood pressure level through the blood pressure tracking from childhood to adulthood. Hence, the prevention of cardiovascular disease in adulthood begins in childhood through identification of preventable risk factors as for example obesity and passive smoking and recognition of risk groups like small for gestational age or preterm children.
authors.affiliation: Pädiatrische Nephrologie, Medizinische Universitäts-Kinderklinik, Inselspital, Bern.
authors.forename: Barbara S
authors.initials: BS
authors.lastname: Bucher
authors.forename: Sibyelle
authors.initials: S
authors.lastname: Tschumi
authors.forename: Giacomo D
authors.initials: GD
authors.lastname: Simonetti
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D047109:Fetal Development; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006801:Humans; D006973:Hypertension / Q000209:etiology* / Q000235:genetics; D007231:Infant, Newborn; D009765:Obesity / Q000150:complications; D011247:Pregnancy; D014028:Tobacco Smoke Pollution / Q000009:adverse effects; D055815:Young Adult
chemical_list: D014028:Tobacco Smoke Pollution