title: [Long-term outcome of patients with renal transplant and neural tube defect].
abstract: OBJECTIVE
  To evaluate the long term outcome of renal transplant in patients with a neural tube defect causing voiding dysfunctions.
  
  
  METHODS
  Between 1993 and 2010, 18 cadaveric renal transplants were performed in 16 patients (5 females and 11 males) older than 15 years with a neural tube defect and voiding dysfunction.
  
  
  RESULTS
  The patients had dialysis since the mean age of 27.4 and have been transplanted at the mean age of 32.2. The survival rate of the first kidney transplant was 93.75% at 1 year and 63.3% at 5 and 10 years respectively. With a mean follow-up of 6.67 years, 11 out of 16 first transplants remained functional (68.75%) The median survival of the first transplants was 13.52 years. At the end of the follow-up, 13 out of 18 transplants were still functional (72.2%). The mean serum creatinine level was 123.9 micromol/l with a mean glomerular filtration rate estimated by the simplified MDRD formula of 67 ml/min for the 13 still functional transplants. Before transplantation, 66% of patients had a neuro-urologic assessment versus 100% thereafter.
  
  
  CONCLUSIONS
  Renal transplantation in patients with neural tube defect is feasible without surgical particularities to those of other renal failure causes. These type of patients represented less than 1% of the followed cohort with an average graft survival rate of 63.3% at five and 10 years. The median survival time of the first graft was 13.52 years.
authors.affiliation: Service d'urologie, transplantation rénale et andrologie, CHU Rangueil, TSA 50032, 31059 Toulouse, France. olivier.abbo@gmail.com
authors.forename: O
authors.initials: O
authors.lastname: Abbo
authors.forename: N
authors.initials: N
authors.lastname: Mingat
authors.forename: M
authors.initials: M
authors.lastname: Roumiguié
authors.forename: J-B
authors.initials: JB
authors.lastname: Beauval
authors.forename: B
authors.initials: B
authors.lastname: Bordier
authors.forename: F
authors.initials: F
authors.lastname: Sallusto
authors.forename: B
authors.initials: B
authors.lastname: Malavaud
authors.forename: L
authors.initials: L
authors.lastname: Rostaing
authors.forename: P
authors.initials: P
authors.lastname: Rischmann
authors.forename: N
authors.initials: N
authors.lastname: Kamar
authors.forename: X
authors.initials: X
authors.lastname: Gamé
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology* / Q000601:surgery*; D016030:Kidney Transplantation; D008297:Male; D009436:Neural Tube Defects / Q000150:complications*; D013997:Time Factors; D016896:Treatment Outcome