title: Usefulness of tissue transglutaminase type 2 antibodies in early pregnancy.
abstract: Celiac disease (CD), an autoimmune disease triggered by dietary gluten, is a multi-systemic disorder that primarily results in mucosal damage of the small intestine. Reproductive disorders and pregnancy complications have been associated with CD. Conflicting results have been published concerning CD and the risk of impaired fetal growth with reduced birthweight. The aim of our multicentric, perspective, case-control study was to determine the prevalence of undiagnosed CD in mothers of small for gestational age (SGA) newborns in two regions of Italy. The study included 480 mothers: group A consisted of 284 SGA newborns' mothers and group B consisted of 196 appropriate for gestational age (AGA) newborns' mothers. Tissue transglutaminase type 2 antibodies (TG2) IgA and IgG were measured in blood samples. We diagnosed two new cases of CD in asymptomatic mothers. It may be appropriate to include the TG2 to the panel of prenatal blood test.
authors.affiliation: Department of Gynecology, Obstetrics and Neonatology, Section of Neonatology and NICU, University of Bari, Bari, Italy. baldassarre@bioetaev.uniba.it
authors.forename: Maria Elisabetta
authors.initials: ME
authors.lastname: Baldassarre
authors.forename: Annamaria
authors.initials: A
authors.lastname: Laneve
authors.forename: Antonietta
authors.initials: A
authors.lastname: Fontana
authors.forename: Fabio
authors.initials: F
authors.lastname: Manca
authors.forename: Gennaro
authors.initials: G
authors.lastname: Salvia
authors.forename: Patrizia
authors.initials: P
authors.lastname: Barcaglioni
authors.forename: Adolfo
authors.initials: A
authors.lastname: Cella
authors.forename: Silvia
authors.initials: S
authors.lastname: Giannuzzo
authors.forename: Luigi
authors.initials: L
authors.lastname: Esposito
authors.forename: Teresa
authors.initials: T
authors.lastname: Capursi
authors.forename: Carla
authors.initials: C
authors.lastname: Mastrorilli
authors.forename: Alexander
authors.initials: A
authors.lastname: Padovano
authors.forename: Nicola
authors.initials: N
authors.lastname: Laforgia
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology; D002446:Celiac Disease / Q000097:blood* / Q000276:immunology; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood* / Q000276:immunology; D019204:GTP-Binding Proteins / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood* / Q000276:immunology; D007074:Immunoglobulin G / Q000097:blood* / Q000276:immunology; D007230:Infant, Low Birth Weight / Q000097:blood* / Q000276:immunology; D007231:Infant, Newborn; D011247:Pregnancy; D011446:Prospective Studies; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D000091345:Protein Glutamine gamma Glutamyltransferase 2; D011503:Transglutaminases; D019204:GTP-Binding Proteins