title: Network analysis of oyster transcriptome revealed a cascade of cellular responses during recovery after heat shock.
abstract: Oysters, as a major group of marine bivalves, can tolerate a wide range of natural and anthropogenic stressors including heat stress. Recent studies have shown that oysters pretreated with heat shock can result in induced heat tolerance. A systematic study of cellular recovery from heat shock may provide insights into the mechanism of acquired thermal tolerance. In this study, we performed the first network analysis of oyster transcriptome by reanalyzing microarray data from a previous study. Network analysis revealed a cascade of cellular responses during oyster recovery after heat shock and identified responsive gene modules and key genes. Our study demonstrates the power of network analysis in a non-model organism with poor gene annotations, which can lead to new discoveries that go beyond the focus on individual genes.
authors.affiliation: Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences, Ocean University of China, Qingdao, China.
authors.forename: Lingling
authors.initials: L
authors.lastname: Zhang
authors.forename: Rui
authors.initials: R
authors.lastname: Hou
authors.forename: Hailin
authors.initials: H
authors.lastname: Su
authors.forename: Xiaoli
authors.initials: X
authors.lastname: Hu
authors.forename: Shi
authors.initials: S
authors.lastname: Wang
authors.forename: Zhenmin
authors.initials: Z
authors.lastname: Bao
mesh_terms: D000818:Animals; D016000:Cluster Analysis; D020869:Gene Expression Profiling; D053263:Gene Regulatory Networks; D018869:Heat-Shock Response / Q000235:genetics*; D010125:Ostreidae / Q000235:genetics*; D059467:Transcriptome