title: Genomic comparison between a virulent type A1 strain of Francisella tularensis and its attenuated O-antigen mutant.
abstract: We report the complete genome sequences of TI0902, a highly virulent type A1 strain, and TIGB03, a related, attenuated chemical mutant strain. Compared to the wild type, the mutant strain had 45 point mutations and a 75.9-kb duplicated region that had not been previously observed in Francisella species.
authors.affiliation: Department of Biological Sciences, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA.
authors.forename: Thero
authors.initials: T
authors.lastname: Modise
authors.forename: Cheryl
authors.initials: C
authors.lastname: Ryder
authors.forename: Shrinivasrao P
authors.initials: SP
authors.lastname: Mane
authors.forename: Aloka B
authors.initials: AB
authors.lastname: Bandara
authors.forename: Roderick V
authors.initials: RV
authors.lastname: Jensen
authors.forename: Thomas J
authors.initials: TJ
authors.lastname: Inzana
mesh_terms: D005604:Francisella tularensis / Q000145:classification / Q000235:genetics* / Q000472:pathogenicity*; D016680:Genome, Bacterial; D008969:Molecular Sequence Data; D009154:Mutation; D019081:O Antigens / Q000235:genetics*; D014774:Virulence
chemical_list: D019081:O Antigens