title: Cardioprotective effect of a biofermented nutraceutical on endothelial function in healthy middle-aged subjects.
abstract: We tested a biofermented nutraceutical (FPP) that has been previously shown to positively modulate nitric oxide (NO). Forty-two healthy middle-aged subjects were given 3 grams of FPP three times a day for 6 weeks, and tests were repeated at 3 and 6 weeks; the control group was given a placebo. Flow-mediated dilation (FMD) was measured together with NO compounds (nitrogen oxides [NOx]: NO(2)(-)+NO(3)(-)) plasma levels and asymmetrical dimethylarginine (ADMA). In the interventional group, overall FMD significantly increased from 4.2% to 7.3% (p<0.05 vs. placebo). A significant increase in plasma NO and a decrease in ADMA were detected after consumption of FPP (p<0.01). Although larger studies are awaited, it appears that, at least in healthy individuals, such nutraceutical intervention by positively acting on significant cardiovascular parameters can be considered in the armamentarium of a proactive age-management strategy.
authors.affiliation: ReGenera Res Group for Aging Intervention, Milan, Italy. fmarchimede@libero.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Marotta
authors.forename: Hariom
authors.initials: H
authors.lastname: Yadav
authors.forename: Archana
authors.initials: A
authors.lastname: Kumari
authors.forename: Roberto
authors.initials: R
authors.lastname: Catanzaro
authors.forename: Shalini
authors.initials: S
authors.lastname: Jain
authors.forename: Ascanio
authors.initials: A
authors.lastname: Polimeni
authors.forename: Aldo
authors.initials: A
authors.lastname: Lorenzetti
authors.forename: Vincenzo
authors.initials: V
authors.lastname: Soresi
mesh_terms: D000328:Adult; D000367:Age Factors; D001120:Arginine / Q000031:analogs & derivatives / Q000097:blood; D002097:C-Reactive Protein / Q000378:metabolism; D002316:Cardiotonic Agents / Q000494:pharmacology; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D002319:Cardiovascular System / Q000187:drug effects; D019587:Dietary Supplements; D004730:Endothelium, Vascular / Q000473:pathology*; D005260:Female; D005285:Fermentation; D006801:Humans; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D009569:Nitric Oxide / Q000037:antagonists & inhibitors / Q000097:blood / Q000378:metabolism; D010919:Placebos; D013997:Time Factors
chemical_list: D002316:Cardiotonic Agents; D010919:Placebos; C487735:dimethylarginine; D009569:Nitric Oxide; D002097:C-Reactive Protein; D001120:Arginine