title: Functional MRI evaluation of supplementary motor area language dominance in right- and left-handed subjects.
abstract: Functional magnetic resonance imaging (fMRI) is a non-invasive brain imaging technique widely used in the evaluation of the brain function that provides images with high temporal and spatial resolution. Investigation of the supplementary motor area (SMA) function is critical in the pre-surgical evaluation of neurological patients, since marked individual differences and complex overlapping with adjacent cortical areas exist, and it is important to spare the SMA from lesions when adjacent cortical tissue is surgically removed. We used fMRI to assess the activity of SMA in six right-handed and six left-handed healthy volunteers when a task requiring silent repetition of a series of words was given. Brain activation areas in each of the subjects were localized according to the standard Talairach coordinate space, and the individual voxels for each map were compared after 3D sagittal images were created and SMA was delimited. Quantitative analysis of hemispheric and bilateral SMA activation was described as mean ± standard deviation of hot points/total points. The results show that the language task induced bilateral SMA activation. Left SMA activation was significantly higher than right SMA activation in both right-handed and left-handed subjects.
authors.affiliation: Post-Graduation Program in Medical Clinics and Health Sciences, School of Medicine, Pontifical Catholic University, Porto Alegre, Rio Grande do Sul, Brazil. dalacorte@gmail.com
authors.forename: Amauri
authors.initials: A
authors.lastname: Dalacorte
authors.forename: Mirna Wetters
authors.initials: MW
authors.lastname: Portuguez
authors.forename: Carlos Magno
authors.initials: CM
authors.lastname: Maurer das Neves
authors.forename: Maurício
authors.initials: M
authors.lastname: Anes
authors.forename: Jaderson Costa
authors.initials: JC
authors.lastname: Dacosta
mesh_terms: D000328:Adult; D001931:Brain Mapping; D005625:Frontal Lobe / Q000502:physiology*; D007839:Functional Laterality / Q000502:physiology*; D059907:Functional Neuroimaging; D006801:Humans; D007802:Language; D008279:Magnetic Resonance Imaging; D009044:Motor Cortex / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology*