title: Medial temporal atrophy and memory dysfunction in poststroke cognitive impairment-no dementia.
abstract: OBJECTIVE
  It was recently reported that the prevalence of poststroke memory dysfunction might be higher than previously thought. Stroke may exist concomitantly with underlying Alzheimer's disease (AD), and so we determined whether post-stroke memory dysfunction indicates manifestation of underlying subclinical AD.
  
  
  METHODS
  Of 1201 patients in a prospective cognitive assessment database, we enrolled subjects with poststroke amnestic vascular cognitive impairment-no dementia (aVCIND; n=48), poststroke nonamnestic vascular cognitive impairment-no dementia (naVCIND; n=50), and nonstroke amnestic mild cognitive impairment (aMCI; n=65). All subjects had cognitive deficits, but did not meet the criteria for dementia. A standardized neuropsychological test battery and magnetic resonance imaging were performed at least 90 days after the index stroke (mean, 473 days). Visual assessment of medial temporal atrophy (MTA) was used as a measure of underlying AD pathology.
  
  
  RESULTS
  The MTA score was significantly lower in the naVCIND group (0.64±0.85, mean±SD) than in the aVCIND (1.10±1.08) and aMCI (1.45±1.13; p<0.01) groups. Multivariable ordinal logistic regression analysis revealed that compared with naVCIND, aVCIND [odds ratio (OR)=2.69; 95% confidence interval (CI)=1.21-5.99] and aMCI (OR=5.20; 95% CI=2.41-11.23) were significantly associated with increasing severity of MTA.
  
  
  CONCLUSIONS
  Our findings show that compared with poststroke naVCIND, the odds of having more-severe MTA were increased for poststroke aVCIND and nonstroke aMCI.
authors.affiliation: Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
authors.forename: Beom Joon
authors.initials: BJ
authors.lastname: Kim
authors.forename: Mi-Young
authors.initials: MY
authors.lastname: Oh
authors.forename: Myung Suk
authors.initials: MS
authors.lastname: Jang
authors.forename: Moon-Ku
authors.initials: MK
authors.lastname: Han
authors.forename: Jisung
authors.initials: J
authors.lastname: Lee
authors.forename: Juneyoung
authors.initials: J
authors.lastname: Lee
authors.forename: Yeonwook
authors.initials: Y
authors.lastname: Kang
authors.forename: Kyung-Ho
authors.initials: KH
authors.lastname: Yu
authors.forename: Byung-Chul
authors.initials: BC
authors.lastname: Lee
authors.forename: Sangyun
authors.initials: S
authors.lastname: Kim
authors.forename: Byung-Woo
authors.initials: BW
authors.lastname: Yoon
authors.forename: Hee-Joon
authors.initials: HJ
authors.lastname: Bae