title: Serum 25 hydroxy-vitamin D does not exhibit an acute phase reaction after acute myocardial infarction.
abstract: BACKGROUND
  There is growing epidemiological evidence linking serum 25 hydroxy-vitamin D (25(OH)D) concentrations to outcome in cardiovascular and other diseases. We have studied patients with acute myocardial infarction (AMI) to determine if they exhibit an acute phase reaction affecting 25(OH)D.
  
  
  METHODS
  Patients (n=32) with first AMI who had been treated with primary percutaneous coronary intervention within 12 h of symptom onset had venous blood samples taken two days, one week, one month and three months after presentation. Samples were analysed for troponin I, C-reactive protein (CRP) and 25(OH)D.
  
  
  RESULTS
  All patients had significant rises in troponin confirming the myocardial damage and CRP, both of which resolved by 28 days. In contrast, 25(OH)D remained unchanged throughout the 90-day observation period with a median concentration of 46 nmol/L.
  
  
  CONCLUSIONS
  Serum 25(OH)D does not change after AMI and is likely to be a reliable marker of vitamin D status in patients with cardiovascular disease.
authors.affiliation: Clinical Biochemistry, Leeds General Infirmary, Leeds LS1 3EX, UK. julian.barth@leedsth.nhs.uk
authors.forename: J H
authors.initials: JH
authors.lastname: Barth
authors.forename: H P
authors.initials: HP
authors.lastname: Field
authors.forename: A N
authors.initials: AN
authors.lastname: Mather
authors.forename: S
authors.initials: S
authors.lastname: Plein
mesh_terms: D000210:Acute-Phase Reaction / Q000097:blood*; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: D014807:Vitamin D; C104450:25-hydroxyvitamin D