title: Systematic evaluations regarding interparticular mass transfer in spheronization.
abstract: Pellets are frequently used in pharmaceutical applications. The extrusion-spheronization process is a well-established technique used to produce pellets of a spherical shape and narrow size distribution. In this process, cylindrical extrudates are transformed into spherical pellets by spheronization. Most established mechanisms consider only breakage and deformation to explain pellet formation. An interaction between the rounding extrudates via adhesion of fine particles was not considered for many years. This study deals with the evolution of pellet properties over time during the spheronization process in order to quantify the influence of pellet interactions on their properties. Therefore the most important pelletization aids (MCCI, MCCII and κ-carrageenan) were investigated using acetaminophen as a model drug and lactose as a filler. In the first seconds of the spheronization process, a high fine fraction was seen which decreased during the process. Simultaneously, the material transferred between the pellets increased. However the fine fraction is not high enough to explain the mass transfer; therefore a direct transfer between the pellets was assumed. The pelletization aid has a huge influence on the amount of mass transferred. Whereas κ-carrageenan leads to a quite low mass transfer of 15%, MCCI and MCCII show higher values up to 25%.
authors.affiliation: Institute of Pharmaceutics and Biopharmaceutics, Heinrich Heine University, Duesseldorf, Germany.
authors.forename: Martin
authors.initials: M
authors.lastname: Koester
authors.forename: Emilie
authors.initials: E
authors.lastname: Willemsen
authors.forename: Cornelia
authors.initials: C
authors.lastname: Krueger
authors.forename: Markus
authors.initials: M
authors.lastname: Thommes
mesh_terms: D000082:Acetaminophen / Q000737:chemistry*; D002351:Carrageenan / Q000737:chemistry*; D002482:Cellulose / Q000737:chemistry*; D004339:Drug Compounding / Q000379:methods*; D005079:Excipients / Q000737:chemistry*
chemical_list: D005079:Excipients; D000082:Acetaminophen; D002351:Carrageenan; D002482:Cellulose; C109691:microcrystalline cellulose