title: Successful treatment of T4 renal cell carcinoma after a neoadjuvant targeted therapy using sunitinib: report of a case.
abstract: Since the introduction of targeted therapy, treatment of metastatic renal cell carcinoma (RCC) has undergone dramatic changes. Responses to targeted therapy within the primary tumor and metastatic lesions are novel findings not seen with immunotherapeutic-based strategies. We report here a case of T4 RCC in which cytoreductive nephrectomy became possible after a neoadjuvant targeted therapy using sunitinib. Our experience with the present case suggests that targeted therapy in the neoadjuvant setting may have a variety of potential applications. Further investigations should be encouraged.
authors.affiliation: Department of Urology, Kurume University School of Medicine, Kurume University, Kurume, Japan.
authors.forename: Kousuke
authors.initials: K
authors.lastname: Ueda
authors.forename: Masanori
authors.initials: M
authors.lastname: Noguchi
authors.forename: Sigetaka
authors.initials: S
authors.lastname: Suekane
authors.forename: Fukuko
authors.initials: F
authors.lastname: Moriya
authors.forename: Rikako
authors.initials: R
authors.lastname: Nagayoshi
authors.forename: Kazuhisa
authors.initials: K
authors.lastname: Ejima
authors.forename: Kousuke
authors.initials: K
authors.lastname: Momozono
authors.forename: Kei
authors.initials: K
authors.lastname: Matsuoka
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002292:Carcinoma, Renal Cell / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D007211:Indoles / Q000627:therapeutic use*; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000601:surgery; D008297:Male; D020360:Neoadjuvant Therapy; D009392:Nephrectomy; D011758:Pyrroles / Q000627:therapeutic use*; D000077210:Sunitinib; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D007211:Indoles; D011758:Pyrroles; D000077210:Sunitinib