title: Glioblastoma with oligodendroglial components: glioblastoma or anaplastic oligodendroglial tumors.
abstract: There have been some recent reports about glioblastoma with oligodendroglial (OG) components and malignant glioma with primitive neuroectodermal tumor (PNET)-like components. We investigated whether the presence and extent of OG components and PNET-like components influenced the prognosis in patients with glioblastoma. Eighty-six patients with glioblastoma were divided into an OG group (28 %), which revealed areas with a honeycomb appearance, and a non-OG group (72 %) without a honeycomb appearance. Patients with glioblastoma were also divided into a PNET group (27 %), which revealed areas with PNET-like features defined as neoplastic cells with high N/C ratios and hyperchromatic oval-carrot-shaped nuclei, and lacked the typical honeycomb appearance, and a non-PNET group (73 %) without PNET features. There were no significant differences in overall survival among the OG, the non-OG, the PNET, and the non-PNET groups. Two patients who survived longer than 36 months had both OG and PNET components with 1p or 19q loss of heterozygosity. Perinuclear halo, which is a characteristic feature of oligodendrogliomas, is an artifact of tissue fixation. Therefore, we should not readily use the term glioblastoma with OG components. PNET-like components, which are considered rare in malignant gliomas, may be frequently identified in glioblastomas.
authors.affiliation: Department of Neurosurgery, Faculty of Medical Sciences, University of Fukui, Eiheiji, Japan. takeu@u-fukui.ac.jp
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Takeuchi
authors.forename: Tetsuya
authors.initials: T
authors.lastname: Hosoda
authors.forename: Ryuhei
authors.initials: R
authors.lastname: Kitai
authors.forename: Toshiaki
authors.initials: T
authors.lastname: Kodera
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Arishima
authors.forename: Kenzo
authors.initials: K
authors.lastname: Tsunetoshi
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Neishi
authors.forename: Takahiro
authors.initials: T
authors.lastname: Yamauchi
authors.forename: Kazufumi
authors.initials: K
authors.lastname: Sato
authors.forename: Yoshiyuki
authors.initials: Y
authors.lastname: Imamura
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Itoh
authors.forename: Toshihiko
authors.initials: T
authors.lastname: Kubota
authors.forename: Ken-ichiro
authors.initials: K
authors.lastname: Kikuta
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000401:mortality / Q000473:pathology*; D005260:Female; D005909:Glioblastoma / Q000401:mortality / Q000473:pathology*; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D018242:Neuroectodermal Tumors, Primitive / Q000401:mortality / Q000473:pathology*; D009837:Oligodendroglioma / Q000401:mortality / Q000473:pathology*