title: Flow synthesis using gaseous ammonia in a Teflon AF-2400 tube-in-tube reactor: Paal-Knorr pyrrole formation and gas concentration measurement by inline flow titration.
abstract: Using a simple and accessible Teflon AF-2400 based tube-in-tube reactor, a series of pyrroles were synthesised in flow using the Paal-Knorr reaction of 1,4-diketones with gaseous ammonia. An inline flow titration technique allowed measurement of the ammonia concentration and its relationship to residence time and temperature.
authors.affiliation: Whiffen Laboratory, Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
authors.forename: Philippa B
authors.initials: PB
authors.lastname: Cranwell
authors.forename: Matthew
authors.initials: M
authors.lastname: O'Brien
authors.forename: Duncan L
authors.initials: DL
authors.lastname: Browne
authors.forename: Peter
authors.initials: P
authors.lastname: Koos
authors.forename: Anastasios
authors.initials: A
authors.lastname: Polyzos
authors.forename: Miguel
authors.initials: M
authors.lastname: Peña-López
authors.forename: Steven V
authors.initials: SV
authors.lastname: Ley
mesh_terms: D000641:Ammonia / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic / Q000295:instrumentation*; D011138:Polytetrafluoroethylene / Q000737:chemistry*; D011758:Pyrroles / Q000138:chemical synthesis* / Q000737:chemistry*
chemical_list: D011758:Pyrroles; D000641:Ammonia; D011138:Polytetrafluoroethylene