title: Association between CASP7 and CASP14 genetic polymorphisms and the risk of childhood leukemia.
abstract: Current evidence suggests that apoptosis and the cell cycle system play an important role in cancer development. To identify susceptible genetic markers in these mechanisms, we did an association study in 63 patients and 148 controls. A total of 304 SNPs in 31 gene regions were selected. We evaluated an association at a gene region level by computing the minimum P-value (minP) and doing the false discovery rate (FDR) test. Both SNP and gene-based analyses presented associations with the risk of childhood leukemia for 5 genes: CASP7, CASP14, CASP8AP2, MYC, and RIPK1 (P(trend)<0.05). There were statistically significant associations for CASP7 (rs12416109 and rs3814231, P(trend) = 0.002 and 0.009, respectively, minP = 0.013, FDR = 0.042) and CASP14 (rs8110862, P(trend)<0.001, minP = 0.002, FDR = 0.027). This study suggests that genetic polymorphisms in apoptosis and cell cycle related genes might play a role in childhood leukemia development.
authors.affiliation: Department of Biomedical Sciences, Graduate School of Seoul National University, Seoul, Republic of Korea.
authors.forename: Chulbum
authors.initials: C
authors.lastname: Park
authors.forename: Sohee
authors.initials: S
authors.lastname: Han
authors.forename: Kyoung-Mu
authors.initials: KM
authors.lastname: Lee
authors.forename: Ji-Yeob
authors.initials: JY
authors.lastname: Choi
authors.forename: Nan
authors.initials: N
authors.lastname: Song
authors.forename: Sujee
authors.initials: S
authors.lastname: Jeon
authors.forename: Sue K
authors.initials: SK
authors.lastname: Park
authors.forename: Hyo Seop
authors.initials: HS
authors.lastname: Ahn
authors.forename: Hee Young
authors.initials: HY
authors.lastname: Shin
authors.forename: Hyoung Jin
authors.initials: HJ
authors.lastname: Kang
authors.forename: Hong Hoe
authors.initials: HH
authors.lastname: Koo
authors.forename: Jong Jin
authors.initials: JJ
authors.lastname: Seo
authors.forename: Ji Eun
authors.initials: JE
authors.lastname: Choi
authors.forename: Daehee
authors.initials: D
authors.lastname: Kang
mesh_terms: D000293:Adolescent; D017209:Apoptosis / Q000235:genetics; D016022:Case-Control Studies; D053179:Caspase 7 / Q000235:genetics*; D020169:Caspases / Q000235:genetics*; D002453:Cell Cycle / Q000235:genetics; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002648:Child; D005260:Female; D056726:Genetic Association Studies; D006801:Humans; D007723:Korea; D007938:Leukemia / Q000235:genetics* / Q000473:pathology; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012306:Risk
chemical_list: C506446:CASP14 protein, human; C505520:CASP7 protein, human; D053179:Caspase 7; D020169:Caspases