title: Extended gastritis cystica profunda associated with Epstein-Barr virus-positive dysplasia and carcinoma with lymphoid stroma.
abstract: We report a case of gastritis cystica porfunda (GCP) associated with gastric carcinoma with lymphoid stroma (CLS). There was dysplastic change in the transitional area between GCP and CLS. Epstein-Barr virus (EBV) in situ hybridization (ISH) revealed positive reaction at the dysplastic area as well as at the CLS area. Immunohistochemical staining disclosed that dysplastic epithelium was similar to GCP in CK 20, MUC5AC, and E-cadherin expression, but similar to CLS in MUC6, CEA, p53, c-erb-B2, and EBV-ISH expression. Results of the EBV-ISH suggested that EBV infection may play a role in dysplastic change.
authors.affiliation: Department of Pathology, Inha University College of Medicine, Incheon, Korea.
authors.forename: Lucia
authors.initials: L
authors.lastname: Kim
authors.forename: Joon Mee
authors.initials: JM
authors.lastname: Kim
authors.forename: Yoon Seok
authors.initials: YS
authors.lastname: Hur
authors.forename: Yong Woon
authors.initials: YW
authors.lastname: Shin
authors.forename: In Suh
authors.initials: IS
authors.lastname: Park
authors.forename: Suk Jin
authors.initials: SJ
authors.lastname: Choi
authors.forename: Jee Young
authors.initials: JY
authors.lastname: Han
authors.forename: Young Chae
authors.initials: YC
authors.lastname: Chu
authors.forename: Kyu Ho
authors.initials: KH
authors.lastname: Kim
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000601:surgery / Q000821:virology; D014408:Biomarkers, Tumor; D003560:Cysts / Q000473:pathology; D020031:Epstein-Barr Virus Infections / Q000150:complications / Q000473:pathology* / Q000601:surgery; D005549:Foreign-Body Reaction / Q000209:etiology / Q000473:pathology* / Q000601:surgery; D005743:Gastrectomy; D005756:Gastritis / Q000473:pathology* / Q000821:virology; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D017403:In Situ Hybridization; D008221:Lymphoid Tissue / Q000473:pathology / Q000821:virology; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions / Q000473:pathology / Q000601:surgery / Q000821:virology; D012367:RNA, Viral / Q000032:analysis; D013274:Stomach Neoplasms / Q000473:pathology* / Q000601:surgery / Q000821:virology; D017154:Stromal Cells / Q000473:pathology / Q000821:virology
chemical_list: D014408:Biomarkers, Tumor; D012367:RNA, Viral