title: [Short-term antibiotic prophylaxis versus long-term antibiotic prophylaxis in major clean-contaminated maxillofacial surgery].
abstract: BACKGROUND
  There is no consensus on the most appropriate duration of antimicrobial prophylaxis (single or multiple dose) in clean-contaminated maxillofacial surgery.
  
  
  OBJECTIVE
  To determine whether short-term antimicrobial prophylaxis is effective compared to long-term antimicrobial prophylaxis in preventing surgical site infection in clean-contaminated maxillofacial surgery.
  
  
  METHODS
  The cohort study included 527 patients. We compared the incidence of surgical site infection in two groups. One group received short-term antibiotic prophylaxis (single dose) and the other group, long-term antimicrobial prophylaxis (multiple dose).
  
  
  RESULTS
  The single dose group showed 5.7% of postoperative infections and the multiple-dose group, 5.9%, with an odds ratio of 0.96 (95% CI 0.44 to 2.10) p = 0.9214.
  
  
  CONCLUSIONS
  No significant differences were found between the infection incidences in the single dose antibiotic prophylaxis group compared with the use of multiple doses.
authors.affiliation: Departamento de Cirugía Maxilofacial, Facultad de Odontología, Universidad de Chile, Santiago, Chile. javm@vtr.net
authors.forename: Julio
authors.initials: J
authors.lastname: Villanueva M
authors.forename: Ignacio
authors.initials: I
authors.lastname: Araya C
authors.forename: Nicolás
authors.initials: N
authors.lastname: Yanine M
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D019072:Antibiotic Prophylaxis / Q000379:methods*; D015331:Cohort Studies; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D019647:Oral Surgical Procedures; D012189:Retrospective Studies; D013530:Surgical Wound Infection / Q000517:prevention & control*; D055815:Young Adult
chemical_list: D000900:Anti-Bacterial Agents