title: Highly selective binding of naphthyridine with a trifluoromethyl group to cytosine opposite an abasic site in DNA duplexes.
abstract: We report on highly selective binding of a naphthyridine derivative with a trifluoromethyl group to cytosine opposite an abasic site in DNA duplexes; the binding-induced fluorescence quenching is applicable to the analysis of a C-related single-base mutation in DNAs amplified by PCR.
authors.affiliation: Department of Chemistry, Graduate School of Science, Tohoku University, Aoba-ku, Sendai 980-8578, Japan.
authors.forename: Yusuke
authors.initials: Y
authors.lastname: Sato
authors.forename: Yushuang
authors.initials: Y
authors.lastname: Zhang
authors.forename: Takehiro
authors.initials: T
authors.lastname: Seino
authors.forename: Takashi
authors.initials: T
authors.lastname: Sugimoto
authors.forename: Seiichi
authors.initials: S
authors.lastname: Nishizawa
authors.forename: Norio
authors.initials: N
authors.lastname: Teramae
mesh_terms: D003596:Cytosine / Q000737:chemistry*; D004247:DNA / Q000737:chemistry* / Q000235:genetics; D017611:Fluorine Compounds / Q000737:chemistry*; D008745:Methylation; D015394:Molecular Structure; D009154:Mutation; D009287:Naphthyridines / Q000737:chemistry*
chemical_list: D017611:Fluorine Compounds; D009287:Naphthyridines; D003596:Cytosine; D004247:DNA