title: Cell therapy for neonatal hypoxia-ischemia and cerebral palsy.
abstract: Perinatal hypoxic-ischemic brain injury remains a major cause of cerebral palsy. Although therapeutic hypothermia is now established to improve recovery from hypoxia-ischemia (HI) at term, many infants continue to survive with disability, and hypothermia has not yet been tested in preterm infants. There is increasing evidence from in vitro and in vivo preclinical studies that stem/progenitor cells may have multiple beneficial effects on outcome after hypoxic-ischemic injury. Stem/progenitor cells have shown great promise in animal studies in decreasing neurological impairment; however, the mechanisms of action of stem cells, and the optimal type, dose, and method of administration remain surprisingly unclear, and some studies have found no benefit. Although cell-based interventions after completion of the majority of secondary cell death appear to have potential to improve functional outcome for neonates after HI, further rigorous testing in translational animal models is required before randomized controlled trials should be considered.
authors.affiliation: Department of Physiology, University of Auckland, New Zealand.
authors.forename: Laura
authors.initials: L
authors.lastname: Bennet
authors.forename: Sidhartha
authors.initials: S
authors.lastname: Tan
authors.forename: Lotte
authors.initials: L
authors.lastname: Van den Heuij
authors.forename: Matthew
authors.initials: M
authors.lastname: Derrick
authors.forename: Floris
authors.initials: F
authors.lastname: Groenendaal
authors.forename: Frank
authors.initials: F
authors.lastname: van Bel
authors.forename: Sandra
authors.initials: S
authors.lastname: Juul
authors.forename: Stephen A
authors.initials: SA
authors.lastname: Back
authors.forename: Frances
authors.initials: F
authors.lastname: Northington
authors.forename: Nicola J
authors.initials: NJ
authors.lastname: Robertson
authors.forename: Carina
authors.initials: C
authors.lastname: Mallard
authors.forename: Alistair Jan
authors.initials: AJ
authors.lastname: Gunn
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002547:Cerebral Palsy / Q000628:therapy*; D006801:Humans; D020925:Hypoxia-Ischemia, Brain / Q000628:therapy*; D007231:Infant, Newborn; D033581:Stem Cell Transplantation / Q000379:methods*