title: [Delayed appearance of symptoms in immediate hypersensitivity: type I sensitization to galactose-α-1,3-galactose].
abstract: Delayed immediate-type allergy to innards and red meat can be mediated by IgE antibodies to galactose-α-1, 3-galactose (α-Gal). Apart from humans and Old World apes, α-Gal is ubiquitously expressed in glycoproteins and glycolipids. Thus, as α-Gal is immunogenic for humans, they can be easily sensitized even through a tick bite. Anti-α-Gal IgG represents approximately 1% of total IgG; IgE antibodies to α-Gal are comparably rare. However, in these patients, consuming red meat and especially innards can lead to the development of immediate type reactions such as urticaria. Cetuximab is a humanized IgG1 antibody containing murine α-Gal. Therefore, allergic reactions may occur with its first administration.
authors.affiliation: Allergologie, Universitäts-Hautklinik, Universitätsklinikum Tübingen, Liebermeisterstr. 25, 72076, Tübingen, Deutschland. Tilo.Biedermann@med.uni-tuebingen.de
authors.forename: T
authors.initials: T
authors.lastname: Biedermann
authors.forename: M
authors.initials: M
authors.lastname: Röcken
mesh_terms: D004187:Disaccharides / Q000009:adverse effects*; D003875:Drug Eruptions / Q000175:diagnosis* / Q000209:etiology; D005512:Food Hypersensitivity / Q000175:diagnosis* / Q000209:etiology*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000175:diagnosis* / Q000209:etiology*; D008297:Male; D008460:Meat / Q000009:adverse effects*; D008875:Middle Aged
chemical_list: D004187:Disaccharides; C055075:galactosyl-(1-3)galactose