title: Evaluating intra-abdominal pressures in a porcine model of acute lung injury by using a wireless motility capsule.
abstract: BACKGROUND
  Intra-vesical pressure measurement as the reference standard for assessing intra-abdominal pressures is mainly indirect and discontinuous. We therefore evaluated a motility capsule for continuous intra-abdominal pressure measurement in an animal model with a high probability for capillary leakage and intestinal edema.
  
  
  METHODS
  Motility capsules were inserted into the stomachs of 8 anesthetized and ventilated pigs. Stomach pH, pressure, and temperature data were wirelessly transmitted to a recorder attached to each animal's abdomen. Intra-gastric pressures measured by the capsule were compared to intra-vesical pressures measured by a pressure transducer system.
  
  
  RESULTS
  The intra-abdominal pressures ranged from 3 to 15 mmHg (7.8 ± 2.4 mmHg [mean ± SD]) measured via the bladder. The capsule pressure recordings ranged from 1 to 3 mmHg (1.7 ± 0.5 mmHg [mean ± SD]). Bland-Altman analysis revealed an unacceptable bias between the 2 methods. The test bias was 6.2 (± 1.4) mmHg and the limits of agreement were from 3.3 to 8.9 mmHg.
  
  
  CONCLUSIONS
  Pressures in the stomach as measured by motility capsule underestimated the intra-vesical pressures. Discrepancies between gastric and intra-vesical pressures could be caused by gastric dilatation or different position of the 2 devices to the zero reference point.
authors.affiliation: Department of Anesthesiology, University of Würzburg, Würzburg, Germany. rauch_s@klinik.uni-wuerzburg.de
authors.forename: Stefan
authors.initials: S
authors.lastname: Rauch
authors.forename: Amelie
authors.initials: A
authors.lastname: Johannes
authors.forename: Bernd
authors.initials: B
authors.lastname: Zollhöfer
authors.forename: Ralf M
authors.initials: RM
authors.lastname: Muellenbach
mesh_terms: D034841:Abdominal Cavity; D055371:Acute Lung Injury / Q000503:physiopathology*; D000818:Animals; D002214:Capsules; D004195:Disease Models, Animal; D005260:Female; D011312:Pressure; D011846:Radio Waves; D013552:Swine; D013686:Telemetry / Q000295:instrumentation*
chemical_list: D002214:Capsules