title: Microbleeds in postmortem brains of patients with Alzheimer disease: a T2*-weighted gradient-echo 7.0 T magnetic resonance imaging study.
abstract: This study aims to determine the distribution and to quantify microbleeds (MBs) in postmortem brains of patients with Alzheimer disease (AD) on T2*-weighted gradient-echo 7.0 T magnetic resonance imaging. Twenty-eight AD brains were compared with 5 controls. The AD brains were subdivided further: 18 without and 10 with additional severe cerebral amyloid angiopathy (AD-CAA). The distribution and the number of cortical focal signal intensity losses, representing MBs, were assessed on coronal sections at the frontal, the central, and the occipital level of a cerebral hemisphere. MBs prevailed in the central sections (P=0.005) of AD brains without CAA, whereas in AD-CAA brains, they were more frequent in all coronal sections (P≤0.002). They prevailed in the deep cortical layers of the AD brains and of the controls (P≤0.03). They were significantly increased in all cortical layers of the AD-CAA brains (P≤0.04), compared with the controls. MBs prevalence in brains of AD patients had a different topographic distribution according to the absence or presence of severe CAA.
authors.affiliation: Université Lille Nord de France, UDSL, EA 1046, Lille University Hospital, Lille, France. dereuck.j@gmail.com
authors.forename: Jacques L
authors.initials: JL
authors.lastname: De Reuck
authors.forename: Charlotte
authors.initials: C
authors.lastname: Cordonnier
authors.forename: Vincent
authors.initials: V
authors.lastname: Deramecourt
authors.forename: Florent
authors.initials: F
authors.lastname: Auger
authors.forename: Nicolas
authors.initials: N
authors.lastname: Durieux
authors.forename: Regis
authors.initials: R
authors.lastname: Bordet
authors.forename: Claude-Alain
authors.initials: CA
authors.lastname: Maurage
authors.forename: Didier
authors.initials: D
authors.lastname: Leys
authors.forename: Florence
authors.initials: F
authors.lastname: Pasquier
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000150:complications / Q000473:pathology*; D001344:Autopsy; D016657:Cerebral Amyloid Angiopathy / Q000150:complications / Q000473:pathology; D002543:Cerebral Hemorrhage / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male