title: [The two faces of p63, Janus of the p53 gene family].
abstract: The TP53 family member TP63 encodes two main isoforms TAp63 and ΔNp63 with distinct, often opposite functions during development and in the adult. ΔNp63 is crucial for the formation of the ectodermal derivatives and epidermis, while TAp63 is essential for heart development. In the adult, ΔNp63 behaves as a cell survival factor, controlling cell proliferation, adhesion and cell differentiation. In contrast, TAp63 is a proapoptotic factor that protects oocytes from genotoxic insults and prevents premature aging of dermal stem cells. In agreement with these activities, TAp63 is often lost and ΔNp63 overexpressed in cancer cells. Because of their opposite and competitive effects, p63 isoforms could be viewed as Janus two faces. The review focuses on the accumulating data on the p63 functions and regulation in the last decade.
authors.affiliation: Inserm U1052, France.
authors.forename: Claude
authors.initials: C
authors.lastname: Caron de Fromentel
authors.forename: Edith
authors.initials: E
authors.lastname: Aberdam
authors.forename: Daniel
authors.initials: D
authors.lastname: Aberdam
mesh_terms: D000328:Adult; D000818:Animals; D004817:Epidermis / Q000196:embryology / Q000378:metabolism / Q000502:physiology; D018507:Gene Expression Regulation, Developmental; D016158:Genes, p53 / Q000502:physiology; D006801:Humans; D008954:Models, Biological; D005810:Multigene Family / Q000502:physiology; D020033:Protein Isoforms; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*; D025521:Tumor Suppressor Proteins / Q000235:genetics / Q000502:physiology*
chemical_list: D020033:Protein Isoforms; C115051:TP63 protein, human; D014157:Transcription Factors; D025521:Tumor Suppressor Proteins