title: Candidate gene polymorphisms and the risk for pregnancy-related venous thrombosis.
abstract: Venous thrombosis (VT) is one of the leading causes of maternal death in the western world, but the genetic causes of pregnancy-related VT are insufficiently understood. The aim of this study was to investigate the association between common genetic variations in candidate genes and pregnancy-related VT. We undertook a hospital based case-control study of women with VT during pregnancy or puerperium; controls were women giving birth without having VT. Single nucleotide polymorphisms (SNPs) were selected in 49 pre-specified candidate genes involved in coagulation, inflammation, and hormonal metabolism in 313 cases and 353 controls. We found new associations between SNPs and total pregnancy-related VT in the genes encoding coagulation factors V and VIII, and p-selectin. Additional new associations between SNPs and antenatal VT were found in the genes encoding the epidermal growth factor receptor, the pregnane X receptor, and protein S. Of 21 SNPs previously associated with thrombotic disease, rs2289252 in F11 and rs3917643 in F3 were associated with pregnancy-related VT, while rs4524 in F5 was associated with antenatal VT.
authors.affiliation: Department of Haematology, Oslo University Hospital Rikshospitalet, Oslo, Norway.
authors.forename: Anders E A
authors.initials: AE
authors.lastname: Dahm
authors.forename: Irene D
authors.initials: ID
authors.lastname: Bezemer
authors.forename: Astrid
authors.initials: A
authors.lastname: Bergrem
authors.forename: Anne F
authors.initials: AF
authors.lastname: Jacobsen
authors.forename: Eva M
authors.initials: EM
authors.lastname: Jacobsen
authors.forename: Grethe
authors.initials: G
authors.lastname: Skretting
authors.forename: Frits R
authors.initials: FR
authors.lastname: Rosendaal
authors.forename: Per Morten
authors.initials: PM
authors.lastname: Sandset
mesh_terms: D000328:Adult; D005165:Factor V / Q000235:genetics*; D005169:Factor VIII / Q000235:genetics*; D005260:Female; D006801:Humans; D019007:P-Selectin / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D049590:Postpartum Period / Q000235:genetics; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000235:genetics*; D012307:Risk Factors; D020246:Venous Thrombosis / Q000235:genetics*
chemical_list: D019007:P-Selectin; C078147:F8 protein, human; D005165:Factor V; D005169:Factor VIII