title: A facile route to boronic acid functional polymeric microspheres via epoxide ring opening.
abstract: Boronic acid-functionalized microspheres are prepared for the first time via mild epoxide ring opening based on porous cross-linked polymeric microspheres (diameter ≈ 10 μm, porosity ≈ 1000 Å). Quantitative chemical analysis by XPS and EA evidences that there is a greater functionalization with boronic acid when employing a sequential synthetic method [1.7 atom% boron (XPS); 1.12 wt% nitrogen (EA)] versus a one-pot synthetic method [0.2 atom% boron (XPS); 0.60 wt% nitrogen (EA)] yielding grafting densities ranging from approximately 2.5 molecules of boronic acid per nm(2) to 1 molecule of boronic acid per nm(2), respectively. Furthermore, the boronic acid-functionalized microspheres are conjugated with a novel fluorescent glucose molecule demonstrating a homogeneous spatial distribution of boronic acid.
authors.affiliation: Preparative Macromolecular Chemistry, Institut für Technische Chemie und Polymerchemie, Karlsruhe Institute of Technology, Engesserstraße 18, 76128 Karlsruhe, Germany.
authors.forename: Andrew P
authors.initials: AP
authors.lastname: Vogt
authors.forename: Vanessa
authors.initials: V
authors.lastname: Trouillet
authors.forename: Alexandra M
authors.initials: AM
authors.lastname: Greiner
authors.forename: Michael
authors.initials: M
authors.lastname: Kaupp
authors.forename: Udo
authors.initials: U
authors.lastname: Geckle
authors.forename: Leonie
authors.initials: L
authors.lastname: Barner
authors.forename: Thorsten
authors.initials: T
authors.lastname: Hofe
authors.forename: Christopher
authors.initials: C
authors.lastname: Barner-Kowollik
mesh_terms: D001897:Boronic Acids / Q000737:chemistry*; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D008863:Microspheres; D015394:Molecular Structure; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D001897:Boronic Acids; D011108:Polymers