title: Engineered arterial models to correlate blood flow to tissue biological response.
abstract: This paper reviews how biomedical engineers, in collaboration with physicians, biologists, chemists, physicists, and mathematicians, have developed models to explain how the impact of vascular interventions on blood flow predicts subsequent vascular repair. These models have become increasingly sophisticated and precise, propelling us toward optimization of cardiovascular therapeutics in general and personalizing treatments for patients with cardiovascular disease.
authors.affiliation: Department of Chemical Engineering, IQS, Universitat Ramon Llull, Barcelona, Spain.|Harvard-MIT Biomedical Engineering Center, Massachusetts Institute of Technology, Cambridge, Massachusetts.
authors.forename: Jordi
authors.initials: J
authors.lastname: Martorell
authors.affiliation: Department of Chemical Engineering, IQS, Universitat Ramon Llull, Barcelona, Spain.|Harvard-MIT Biomedical Engineering Center, Massachusetts Institute of Technology, Cambridge, Massachusetts.
authors.forename: Pablo
authors.initials: P
authors.lastname: Santomá
authors.affiliation: Department of Chemical Engineering, IQS, Universitat Ramon Llull, Barcelona, Spain.
authors.forename: José J
authors.initials: JJ
authors.lastname: Molins
authors.affiliation: Department of Industrial Engineering, IQS, Universitat Ramon Llull, Barcelona, Spain.
authors.forename: Andrés A
authors.initials: AA
authors.lastname: García-Granada
authors.affiliation: Department of Mechanical Engineering, Universidad de Zaragoza, Spain.
authors.forename: José A
authors.initials: JA
authors.lastname: Bea
authors.affiliation: Harvard-MIT Biomedical Engineering Center, Massachusetts Institute of Technology, Cambridge, Massachusetts.|Cardiology Division, Brigham and Women's Hospital, Boston, Massachusetts.
authors.forename: Elazer R
authors.initials: ER
authors.lastname: Edelman
authors.affiliation: Harvard-MIT Biomedical Engineering Center, Massachusetts Institute of Technology, Cambridge, Massachusetts.|Bioengineering Department, IQS, Universitat Ramon Llull, Barcelona, Spain.
authors.forename: Mercedes
authors.initials: M
authors.lastname: Balcells
mesh_terms: D000818:Animals; D001158:Arteries / Q000502:physiology*; D001672:Biocompatible Materials; D001698:Biomedical Engineering; D001783:Blood Flow Velocity / Q000502:physiology; D001807:Blood Vessel Prosthesis; D002318:Cardiovascular Diseases / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D008955:Models, Cardiovascular
chemical_list: D001672:Biocompatible Materials