title: Fetuin-A Characteristics during and after Pregnancy: Result from a Case Control Pilot Study.
abstract: Objective. Fetuin-A has been associated with gestational diabetes mellitus (GDM). We investigated fetuin-A levels during and after pregnancy in women with GDM. Fetuin-A measurements were performed in 10 women with GDM and 10 age and body mass index (BMI) matched healthy pregnant women. All women underwent an oral glucose tolerance test (OGTT) in and 3 months after gestation. Results. Fasting fetuin-A correlated with BMI in women with former GDM (r = 0.90, P < 0.0001) but showed no association with parameters of glucose tolerance in women with GDM or post-GDM. GDM featured significantly lower insulin sensitivity and higher insulin and C-peptide secretion profiles compared to NGT during pregnancy (P < 0.05). Fasting and postprandial fetuin-A did not differ between groups, neither during nor after pregnancy. Conclusion. Fetuin-A is not influenced by glucose tolerance during or after pregnancy or acute glucose elevations following glucose ingestion in young women, but closely relates to BMI early postpartum.
authors.affiliation: 3rd Department of Medicine, Cardiology and Emergency Medicine, Wilhelminen Hospital, Montleartstrasse 37, 1160 Vienna, Austria.
authors.forename: Serdar
authors.initials: S
authors.lastname: Farhan
authors.forename: Ammon
authors.initials: A
authors.lastname: Handisurya
authors.forename: Jelena
authors.initials: J
authors.lastname: Todoric
authors.forename: Andrea
authors.initials: A
authors.lastname: Tura
authors.forename: Giovanni
authors.initials: G
authors.lastname: Pacini
authors.forename: Oswald
authors.initials: O
authors.lastname: Wagner
authors.forename: Katharina
authors.initials: K
authors.lastname: Klein
authors.forename: Rudolf
authors.initials: R
authors.lastname: Jarai
authors.forename: Kurt
authors.initials: K
authors.lastname: Huber
authors.forename: Alexandra
authors.initials: A
authors.lastname: Kautzky-Willer