title: Exploring the molecular mechanism of karrikins and strigolactones.
abstract: Karrikins and strigolactones are novel plant growth regulators that contain similar molecular features, but very little is known about how they elicit responses in plants. A tentative molecular mechanism has previously been proposed involving a Michael-type addition for both compounds. Through structure-activity studies with karrikins, we now propose an alternative mechanism for karrikin and strigolactone mode of action that involves hydrolysis of the butenolide ring.
authors.affiliation: School of Chemistry and Biochemistry, The University of Western Australia, Crawley, WA 6009, Australia. adrian.scaffidi@uwa.edu.au
authors.forename: Adrian
authors.initials: A
authors.lastname: Scaffidi
authors.forename: Mark T
authors.initials: MT
authors.lastname: Waters
authors.forename: Charles S
authors.initials: CS
authors.lastname: Bond
authors.forename: Kingsley W
authors.initials: KW
authors.lastname: Dixon
authors.forename: Steven M
authors.initials: SM
authors.lastname: Smith
authors.forename: Emilio L
authors.initials: EL
authors.lastname: Ghisalberti
authors.forename: Gavin R
authors.initials: GR
authors.lastname: Flematti
mesh_terms: D001665:Binding Sites; D003198:Computer Simulation; D005663:Furans / Q000737:chemistry / Q000494:pharmacology*; D018525:Germination / Q000187:drug effects; D007783:Lactones / Q000737:chemistry / Q000378:metabolism*; D010937:Plant Growth Regulators / Q000737:chemistry / Q000494:pharmacology*; D010940:Plant Proteins / Q000737:chemistry / Q000378:metabolism; D017434:Protein Structure, Tertiary; D011714:Pyrans / Q000737:chemistry / Q000494:pharmacology*; D012639:Seeds / Q000378:metabolism; D032322:Solanum / Q000254:growth & development / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: C488803:3-methyl-2H-furo(2,3-c)pyran-2-one; D005663:Furans; C507382:GR24 compound; D007783:Lactones; D010937:Plant Growth Regulators; D010940:Plant Proteins; D011714:Pyrans