title: Leucyl-tRNA synthetase: double duty in amino acid sensing.
abstract: The cellular response to amino acids is controlled at the molecular level by TORC1. While many of the elements that participate in TORC1 signaling are known, we still have no clear idea how cells sense amino acids. Two recent studies found that leucyl-tRNA synthetase (LRS) is a leucine sensor for TORC1, in both yeast and mammalian cells.
authors.affiliation: Biozentrum, University of Basel, Klingelbergstrasse 50/70, CH-4056 Basel, Switzerland.
authors.forename: Raúl V
authors.initials: RV
authors.lastname: Durán
authors.forename: Michael N
authors.initials: MN
authors.lastname: Hall
mesh_terms: D000818:Animals; D004734:Energy Metabolism; D004789:Enzyme Activation; D006801:Humans; D007930:Leucine / Q000378:metabolism*; D007935:Leucine-tRNA Ligase / Q000378:metabolism*; D008247:Lysosomes / Q000378:metabolism; D008322:Mammals; D000076222:Mechanistic Target of Rapamycin Complex 1; D046912:Multiprotein Complexes / Q000378:metabolism*; D025941:Protein Interaction Mapping; D015398:Signal Transduction; D058570:TOR Serine-Threonine Kinases / Q000378:metabolism*; D015003:Yeasts / Q000201:enzymology
chemical_list: D046912:Multiprotein Complexes; D000076222:Mechanistic Target of Rapamycin Complex 1; D058570:TOR Serine-Threonine Kinases; D007935:Leucine-tRNA Ligase; D007930:Leucine