title: N'-Nitro-2-hydrocarbylidenehydrazinecarboximidamides: design, synthesis, crystal structure, insecticidal activity, and structure-activity relationships.
abstract: A novel series of acyclic imine-substituted nitenpyram analogues were designed and synthesized from nitroaminoguanidine, and their structures were confirmed using X-ray diffraction crystallography. Preliminary bioassays showed that the target molecules exhibited good activities against aphids in laboratory (Myzus persicae Sulzer) and field trials (M. persicae Sulzer and Brevicoryne brassicae Linnaeus). Comparative molecular field analysis and comparative molecular similarity indices analysis were employed to develop a three-dimensional quantitative structure-activity relationship model that describes the insecticidal activity of 21 neonicotinoid derivatives. Simple synthesis, low cost, and good insecticidal activity have made this series of compounds become very promising candidates for future commercial pesticides.
authors.affiliation: Department of Applied Chemistry, College of Science,  China Agricultural University , Beijing 100193, China.
authors.forename: Wangcang
authors.initials: W
authors.lastname: Su
authors.forename: Yihui
authors.initials: Y
authors.lastname: Zhou
authors.forename: Yongqiang
authors.initials: Y
authors.lastname: Ma
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
authors.forename: Zheng
authors.initials: Z
authors.lastname: Zhang
authors.forename: Changhui
authors.initials: C
authors.lastname: Rui
authors.forename: Hongxia
authors.initials: H
authors.lastname: Duan
authors.forename: Zhaohai
authors.initials: Z
authors.lastname: Qin
mesh_terms: D000691:Anabasine / Q000737:chemistry; D000818:Animals; D001042:Aphids; D018360:Crystallography, X-Ray; D006146:Guanidines / Q000737:chemistry; D007097:Imines / Q000737:chemistry*; D007306:Insecticides / Q000138:chemical synthesis / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D000073943:Neonicotinoids; D009574:Nitro Compounds / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry*; D021281:Quantitative Structure-Activity Relationship
chemical_list: D006146:Guanidines; D007097:Imines; D007306:Insecticides; D000073943:Neonicotinoids; D009574:Nitro Compounds; D011725:Pyridines; C464843:nitenpyram; D000691:Anabasine