title: Accumulation of zinc, nickel, lead and cadmium in some organs of rabbits after dietary nickel and zinc inclusion.
abstract: This study reports the effect of dietary nickel (Ni) and a combination of Ni and zinc (Zn) on the accumulation of lead (Pb), cadmium (Cd), Ni and Zn in muscles, liver and kidneys of rabbits. Female rabbits (Oryctolagus cuniculus) of experimental groups were fed a granular mixture with addition of various concentrations of Ni or Ni+Zn (E1 - 17.5 g NiCl(2) per 100 kg of feed mixture, group E2 - 35.0 g NiCl(2) per 100 kg of feed mixture, group E3 - 17.5 g NiCl(2) per 100 kg of feed mixture and 30 g ZnCl(2) per 100 kg of feed mixture, group E4 - 35.0 g NiCl(2) per 100 kg of feed mixture and 30 g ZnCl(2) per 100 kg of feed mixture). Group C without inclusion of Ni or Zn served as control. After the 90-day experimental period biological material (liver, kidney, musculus longissimus dorsi, musculus biceps femoris) was taken from the animals. Samples were analyzed by the AAS method. Ni added to the FM caused an increase in Cd concentration in the kidneys of the rabbits, significantly in the E3 group in comparison with the control group. In the liver an insignificant decrease of Cd concentration was found. Zn addition in the amount of 30 g to the diet caused an increase of Cd level in the kidney as well as in the liver. Ni and Zn treatment caused a significant decrease of Pb accumulation in the m. longissimus dorsi of rabbits. This study indicates that dietary inclusion of Ni and Zn caused specific interactions among the observed metals.
authors.affiliation: Department of Animal Physiology, Faculty of Biotechnology and Food Sciences, Slovak University of Agriculture in Nitra, Nitra, Slovak Republic. anna.kalafova@uniag.sk
authors.forename: Anna
authors.initials: A
authors.lastname: Kalafova
authors.forename: Jaroslav
authors.initials: J
authors.lastname: Kovacik
authors.forename: Marcela
authors.initials: M
authors.lastname: Capcarova
authors.forename: Adriana
authors.initials: A
authors.lastname: Kolesarova
authors.forename: Norbert
authors.initials: N
authors.lastname: Lukac
authors.forename: Robert
authors.initials: R
authors.lastname: Stawarz
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Formicki
authors.forename: Tomasz
authors.initials: T
authors.lastname: Laciak
mesh_terms: D000818:Animals; D005260:Female; D019216:Metals, Heavy / Q000493:pharmacokinetics*; D011817:Rabbits; D013054:Spectrophotometry, Atomic; D014018:Tissue Distribution
chemical_list: D019216:Metals, Heavy