title: Toll-like receptor 3 L412F polymorphisms in infants with bronchiolitis and postbronchiolitis wheezing.
abstract: BACKGROUND
  Innate immunity receptors play a critical role in host defense. In addition, the expression of Toll-like receptors (TLRs) has been connected to allergy and asthma.
  
  
  OBJECTIVE
  : To evaluate the association between the TLR3 L412F polymorphism and viral findings, clinical characteristics and subsequent wheezing in young infants with bronchiolitis.
  
  
  METHODS
  In all, 129 full-term infants hospitalized for bronchiolitis at age <6 months have been followed-up until the mean age of 1.5 years. Genotyping of the TLR3 L412F gene mutation was made by pyrosequencing.
  
  
  RESULTS
  TLR3 L412F gene polymorphism including the minor allele T was overrepresented (52%) in infants hospitalized with bronchiolitis. The presence of the major allele C as homozygous was associated with repeated postbronchiolitis wheezing (7.06, 95% confidence interval 2.30-21.66).
  
  
  CONCLUSIONS
  Preliminary evidence was found that TLR3 L412F gene polymorphism may be associated with bronchiolitis leading to hospitalization and postbronchiolitis wheezing.
authors.affiliation: Seinäjoki Central Hospital, Seinäjoki, Finland. kirsi.nuolivirta@ fimnet.fi
authors.forename: Kirsi
authors.initials: K
authors.lastname: Nuolivirta
authors.forename: Qiushui
authors.initials: Q
authors.lastname: He
authors.forename: Juho
authors.initials: J
authors.lastname: Vuononvirta
authors.forename: Petri
authors.initials: P
authors.lastname: Koponen
authors.forename: Merja
authors.initials: M
authors.lastname: Helminen
authors.forename: Matti
authors.initials: M
authors.lastname: Korppi
mesh_terms: D001988:Bronchiolitis / Q000235:genetics* / Q000821:virology; D005260:Female; D005500:Follow-Up Studies; D005838:Genotype; D006801:Humans; D007223:Infant; D016015:Logistic Models; D008297:Male; D020641:Polymorphism, Single Nucleotide; D012135:Respiratory Sounds / Q000235:genetics*; D012136:Respiratory Syncytial Viruses / Q000302:isolation & purification; D012229:Rhinovirus / Q000302:isolation & purification; D051196:Toll-Like Receptor 3 / Q000235:genetics*
chemical_list: C495344:TLR3 protein, human; D051196:Toll-Like Receptor 3