title: Chromosome-encoded extended-spectrum class A β-lactamase MIN-1 from Minibacterium massiliensis.
abstract: Minibacterium massiliensis strain CIP107820 is a recently discovered waterborne Gram-negative rod isolated from hospital water samples. It harbors a chromosomally located gene encoding an Ambler class A extended-spectrum β-lactamase termed MIN-1, sharing 56%, 54%, and 51% amino acid identities with β-lactamases LUT-1, KPC-2, and CTX-M-2, respectively. β-Lactamase MIN-1 hydrolyzes penicillins, narrow-spectrum cephalosporins, cefotaxime, and, less efficiently, cefepime, while ceftazidime and carbapenems are very poor substrates, and cephamycins and aztreonam are not hydrolyzed.
authors.affiliation: Service de Bactériologie-Virologie, INSERM U914 Emerging Resistance to Antibiotics, Hôpital de Bicêtre, Assistance Publique-Hôpitaux de Paris, Faculté de Médecine et Université Paris-Sud, K-Bicêtre, Paris, France.
authors.forename: Béatrice
authors.initials: B
authors.lastname: Bercot
authors.forename: Patrice
authors.initials: P
authors.lastname: Nordmann
authors.forename: Michel
authors.initials: M
authors.lastname: Drancourt
authors.forename: Laurent
authors.initials: L
authors.lastname: Poirel
mesh_terms: D000077723:Cefepime; D002439:Cefotaxime / Q000378:metabolism / Q000494:pharmacology; D002511:Cephalosporins / Q000378:metabolism / Q000494:pharmacology; D002876:Chromosomes, Bacterial / Q000235:genetics*; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000201:enzymology* / Q000235:genetics*; D008969:Molecular Sequence Data; D010406:Penicillins / Q000378:metabolism / Q000494:pharmacology; D001618:beta-Lactamases / Q000235:genetics / Q000378:metabolism*
chemical_list: D002511:Cephalosporins; D010406:Penicillins; D000077723:Cefepime; D001618:beta-Lactamases; D002439:Cefotaxime