title: [The choice of laboratory biomarkers for early detection of vibration unfavorable impact on human organism].
abstract: The vibration impact on various biochemical, citochemical, immunologic and hematological indicator was studied. It is established that the indicators of oxidative metabolism (the activity of blood superoxide dismutase, neutrophil myeloperoxidase and malonic dialdehyde concentration), the level of immunoglobulin A, M and G, the activity of alkaline and acid phosphatase in neutrophils, the content of creatinine in urine are changed on the pre-clinical stage. The increase of concentration of hemoglobin begins under vibration disease 1 and the character of alteration in erythrocytes volume depends on the evidence of vibration impact. The diagnostic characteristics of various laboratory tests are established The biomarkers are selected to evaluate the health status of workers contacting with vibration. The set of laboratory biomarkers is proposed to apply during the examination of workers contacting with vibration. The implementation of this set permits to detect the early pre-clinical alterations in workers' organism, to assess the evidence of alterations in patients with vibration disease and to establish disorders in patients with late effects of vibration pathology.
authors.forename: N A
authors.initials: NA
authors.lastname: Pavlovskaia
authors.forename: L I
authors.initials: LI
authors.lastname: Antoshina
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism*; D000469:Alkaline Phosphatase / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood / Q000652:urine; D001798:Blood Proteins / Q000378:metabolism*; D003404:Creatinine / Q000652:urine*; D004911:Erythrocyte Volume; D005260:Female; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D009504:Neutrophils / Q000201:enzymology*; D014732:Vibration / Q000009:adverse effects*
chemical_list: D015415:Biomarkers; D001798:Blood Proteins; D008315:Malondialdehyde; D003404:Creatinine; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase