title: Hierarchical formation of supramolecular transient networks in water: a modular injectable delivery system.
abstract: A modular one-component supramolecular transient network in water, based on poly(ethylene glycol) and end-capped with four-fold hydrogen bonding units, is reported. Due to its nonlinear structural formation, this system allows active proteins to be added to the hydrogel during formation. Once implanted in vivo it releases the protein by erosion of both the protein and polymer via dissolution.
authors.affiliation: Institute for Complex Molecular Systems, Eindhoven University of Technology, The Netherlands.
authors.forename: Patricia Y W
authors.initials: PY
authors.lastname: Dankers
authors.forename: Thomas M
authors.initials: TM
authors.lastname: Hermans
authors.forename: Travis W
authors.initials: TW
authors.lastname: Baughman
authors.forename: Yuko
authors.initials: Y
authors.lastname: Kamikawa
authors.forename: Roxanne E
authors.initials: RE
authors.lastname: Kieltyka
authors.forename: Maartje M C
authors.initials: MM
authors.lastname: Bastings
authors.forename: Henk M
authors.initials: HM
authors.lastname: Janssen
authors.forename: Nico A J M
authors.initials: NA
authors.lastname: Sommerdijk
authors.forename: Antje
authors.initials: A
authors.lastname: Larsen
authors.forename: Marja J A
authors.initials: MJ
authors.lastname: van Luyn
authors.forename: Anton W
authors.initials: AW
authors.lastname: Bosman
authors.forename: Eliane R
authors.initials: ER
authors.lastname: Popa
authors.forename: George
authors.initials: G
authors.lastname: Fytas
authors.forename: E W
authors.initials: EW
authors.lastname: Meijer
mesh_terms: D055419:Bone Morphogenetic Protein 7 / Q000378:metabolism; D004337:Drug Carriers / Q000737:chemistry*; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate / Q000737:chemistry; D006860:Hydrogen Bonding; D058628:Myofibroblasts / Q000378:metabolism; D011092:Polyethylene Glycols / Q000737:chemistry; D014867:Water / Q000737:chemistry*
chemical_list: D055419:Bone Morphogenetic Protein 7; D004337:Drug Carriers; D014867:Water; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011092:Polyethylene Glycols