title: Spectaflavoside A, a new potent iron chelating dimeric flavonol glycoside from the rhizomes of Zingiber spectabile Griff.
abstract: The rhizomes of Zingiber spectabile yielded a new dimeric flavonol glycoside for which the name kaempferol-3-O-(4″-O-acetyl)-α-L-rhamnopyranoside-(I-6,II-8)-kaempferol-3-O-(4″-O-acetyl)-α-L-rhamnopyranoside; spectaflavoside A (1) was proposed, along with kaempferol and its four acetylrhamnosides (2-6), demethoxycurcumin (7) and curcumin (8). The structure of spectaflavoside A was elucidated by spectroscopic methods including, 1D and 2D NMR techniques. This is the first report on the occurrence of a dimeric flavonol glycoside in the Zingiberaceae and the second in nature. Spectaflavoside A was found to be a potent iron chelating agent.
authors.affiliation: Department of Chemistry, Faculty of Science, University Malaya, 50603 Kuala Lumpur, Malaysia.
authors.forename: Yasodha
authors.initials: Y
authors.lastname: Sivasothy
authors.forename: A Hamid A
authors.initials: AH
authors.lastname: Hadi
authors.forename: Khalit
authors.initials: K
authors.lastname: Mohamad
authors.forename: Kok Hoong
authors.initials: KH
authors.lastname: Leong
authors.forename: Halijah
authors.initials: H
authors.lastname: Ibrahim
authors.forename: Shaida Fariza
authors.initials: SF
authors.lastname: Sulaiman
authors.forename: Kheng Leong
authors.initials: KL
authors.lastname: Ooi
authors.forename: Khalijah
authors.initials: K
authors.lastname: Awang
mesh_terms: D017209:Apoptosis / Q000187:drug effects; D045744:Cell Line, Tumor; D019281:Dimerization; D047309:Flavones / Q000737:chemistry* / Q000302:isolation & purification; D044948:Flavonols / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D019073:HT29 Cells; D056945:Hep G2 Cells; D006801:Humans; D007502:Iron Chelating Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D027343:Rhizome / Q000737:chemistry; D030521:Zingiberaceae / Q000737:chemistry*
chemical_list: C574998:3-O-(4'-O-acetyl)rhamnopyranoside-(I-6,II-8)-kaempferol-3-O-(4'-O-acetyl)rhamnopyranoside; D047309:Flavones; D044948:Flavonols; D006027:Glycosides; D007502:Iron Chelating Agents