title: Differential expression of the angiogenesis growth factors in psoriasis vulgaris.
abstract: BACKGROUND
  Angiogenesis has been reported to be one of the contributory factors to the pathogenesis of psoriasis vulgaris. This study aims to compare the expression of different angiogenesis growth factors namely (1) the vascular endothelial growth factor (VEGF) subfamily: A, B, C, D and placenta growth factor (PlGF); (2) nerve growth factor (NGF) and (3) von Willebrand factor (vWFr) in the skins of patients with psoriasis vulgaris and non-psoriatic volunteers.
  
  
  RESULTS
  Comparative immunohistochemistry study was performed on the paraffin-sectioned psoriatic and healthy skins with the abovementioned markers. VEGF-C (p = 0.016) and NGF (p = 0.027) were expressed intensely in the cases when compared with the controls. The NGF was the only marker that was solely expressed in the cases and absent in all the controls.
  
  
  CONCLUSIONS
  The NGF (angiogenesis) and VEGF-C (lymphangiogenesis) might play a crucial role in the pathogenesis of psoriasis vulgaris and could be researched further as potential new targeted therapies for psoriasis vulgaris.
authors.affiliation: Department of Postgraduate Studies and Research, International Medical University, Kuala Lumpur, Malaysia. siawcheok_liew@imu.edu.my
authors.forename: Siaw-Cheok
authors.initials: SC
authors.lastname: Liew
authors.forename: Esha
authors.initials: E
authors.lastname: Das-Gupta
authors.forename: Srikumar
authors.initials: S
authors.lastname: Chakravarthi
authors.forename: Shew-Fung
authors.initials: SF
authors.lastname: Wong
authors.forename: Nagarajah
authors.initials: N
authors.lastname: Lee
authors.forename: Najeeb
authors.initials: N
authors.lastname: Safdar
authors.forename: Adawiyah
authors.initials: A
authors.lastname: Jamil
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D042583:Lymphangiogenesis; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000378:metabolism / Q000473:pathology; D020932:Nerve Growth Factor / Q000096:biosynthesis*; D000072483:Placenta Growth Factor; D011257:Pregnancy Proteins / Q000096:biosynthesis; D011565:Psoriasis / Q000378:metabolism*; D012867:Skin / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology; D042461:Vascular Endothelial Growth Factor A / Q000096:biosynthesis; D042561:Vascular Endothelial Growth Factor B / Q000096:biosynthesis; D042582:Vascular Endothelial Growth Factor C / Q000096:biosynthesis*; D042643:Vascular Endothelial Growth Factor D / Q000096:biosynthesis; D055815:Young Adult; D014841:von Willebrand Factor / Q000096:biosynthesis
chemical_list: D015415:Biomarkers; C000608036:PGF protein, human; D011257:Pregnancy Proteins; D042461:Vascular Endothelial Growth Factor A; D042561:Vascular Endothelial Growth Factor B; D042582:Vascular Endothelial Growth Factor C; D042643:Vascular Endothelial Growth Factor D; D014841:von Willebrand Factor; D000072483:Placenta Growth Factor; D020932:Nerve Growth Factor