title: Asthmatic cough and airway oxidative stress.
abstract: The mechanisms of cough in asthma are unclear. Asthma is associated with an oxidative stress. Many reactive oxygen species sensitize or activate sensory C-fibers which are capable to induce cough. It was hypothesized that oxidative stress in the airways might contribute to the cough severity in asthma. Exhaled breath condensate samples were collected in ten healthy and 26 asthmatic subjects. The concentration of 8-isoprostane was measured. In addition, the subjects filled in Leicester Cough Questionnaire and underwent cough provocation tests with dry air hyperpnoea and hypertonic saline, among other measurements. Among the asthmatic subjects, high 8-isoprostane was associated with severe cough response to hyperpnoea (p=0.001), low Leicester Cough Questionnaire values (indicating severe subjective cough, p=0.02), and usage of combination asthma drugs (p=0.03-0.04). However, the 8-isoprostane concentrations did not differ significantly between the healthy and the asthmatic subjects. Airway oxidative stress may be associated with experienced cough severity and measured cough sensitivity in asthma.
authors.affiliation: Center for Medicine and Clinical Research, Division of Respiratory Medicine, Kuopio University Hospital, Kuopio, Finland. heikki.koskela@kuh.fi
authors.forename: Heikki O
authors.initials: HO
authors.lastname: Koskela
authors.forename: Minna K
authors.initials: MK
authors.lastname: Purokivi
authors.forename: Riina M
authors.initials: RM
authors.lastname: Nieminen
authors.forename: Eeva
authors.initials: E
authors.lastname: Moilanen
mesh_terms: D000328:Adult; D001249:Asthma / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D001944:Breath Tests; D001985:Bronchial Provocation Tests; D016022:Case-Control Studies; D002908:Chronic Disease; D015331:Cohort Studies; D003371:Cough / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology / Q000523:psychology; D015237:Dinoprost / Q000031:analogs & derivatives* / Q000378:metabolism; D045853:Exhalation / Q000502:physiology; D005260:Female; D006801:Humans; D006985:Hyperventilation / Q000150:complications; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D012016:Reference Values; D012720:Severity of Illness Index; D013147:Spirometry; D018709:Statistics, Nonparametric
chemical_list: C075750:8-epi-prostaglandin F2alpha; D015237:Dinoprost