title: Multidrug-resistant (MDR) Klebsiella pneumoniae clinical isolates: a zone of high heterogeneity (HHZ) as a tool for epidemiological studies.
abstract: Comparison of genome-wide, high-resolution restriction maps of Klebsiella pneumoniae clinical isolates, including an NDM-1 producer, and in silico-generated restriction maps of sequenced genomes revealed a highly heterogeneous region we designated the 'high heterogeneity zone' (HHZ). The HHZ consists of several regions, including a 'hot spot' prone to insertions and other rearrangements. The HHZ is a characteristic genomic area that can be used in the identification and tracking of outbreak-causing strains.
authors.affiliation: Department of Biological Science, Center for Applied Biotechnology Studies, California State University Fullerton, Fullerton, CA 92831-3599, USA.
authors.forename: M S
authors.initials: MS
authors.lastname: Ramirez
authors.forename: G
authors.initials: G
authors.lastname: Xie
authors.forename: S H
authors.initials: SH
authors.lastname: Marshall
authors.forename: K M
authors.initials: KM
authors.lastname: Hujer
authors.forename: P S G
authors.initials: PS
authors.lastname: Chain
authors.forename: R A
authors.initials: RA
authors.lastname: Bonomo
authors.forename: M E
authors.initials: ME
authors.lastname: Tolmasky
mesh_terms: D004269:DNA, Bacterial; D004196:Disease Outbreaks; D024901:Drug Resistance, Multiple, Bacterial; D006801:Humans; D007710:Klebsiella Infections / Q000453:epidemiology / Q000382:microbiology*; D007711:Klebsiella pneumoniae / Q000145:classification / Q000187:drug effects* / Q000235:genetics* / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests / Q000379:methods; D017720:Molecular Epidemiology / Q000379:methods; D058889:Molecular Typing / Q000379:methods*; D011110:Polymorphism, Genetic
chemical_list: D004269:DNA, Bacterial