title: Upregulation of plasma insulin-like growth factor binding protein 2 levels after biliopancreatic diversion in humans.
abstract: The biliopancreatic diversion surgery with duodenal switch (BPD-DS) is a surgical procedure that not only induces significant weight loss, but also promotes remission of diabetes. However, the mechanism responsible for this insulin-potentiating effect (both on sensitivity and production) is not yet clearly understood. The insulin-like growth factor (IGF) binding protein 2 (IGFBP-2) is a 36 kDa circulating protein that has been recently suggested to modulate insulin sensitization and fat accumulation. In humans, a low-circulating concentration of IGFBP-2 has been associated with obesity and insulin resistance. We thus tested the hypothesis that BPD-DS would trigger an increase in IGFBP-2 levels. Plasma IGFBP-2 was quantified by enzyme-linked immunosorbent assay in 77 severely obese men and women before and up to 1 year after BPD-DS surgery. Baseline IGFBP-2 levels were 159 ± 17 ng/ml. Plasma IGFBP-2 levels increased significantly as soon as 24 h after BPD-DS surgery and were further augmented at both 6 months and 1 year after the surgery, reaching 748 ± 65 ng/ml. Changes in IGFBP-2 concentrations were significantly and negatively associated with blood glucose, insulin, triglycerides, and total cholesterol levels. The present findings suggest that the rise in IGFBP-2 levels is associated with the improvements in glucose and lipid metabolism in the short- and long-term after BPD-DS. The mechanisms for the augmentation in IGFBP-2 after BPD-DS and its contribution to insulin sensitization remain to be elucidated.
authors.affiliation: Centre de recherche de l'Institut universitaire de cardiologie et de pneumologie de Québec, Laval University, Québec, Quebec, Canada.
authors.forename: Zhuo
authors.initials: Z
authors.lastname: Li
authors.forename: Julie
authors.initials: J
authors.lastname: Martin
authors.forename: Paul
authors.initials: P
authors.lastname: Poirier
authors.forename: Sarah-Maude
authors.initials: SM
authors.lastname: Caron-Cantin
authors.forename: Frédéric-Simon
authors.initials: FS
authors.lastname: Hould
authors.forename: Simon
authors.initials: S
authors.lastname: Marceau
authors.forename: Picard
authors.initials: P
authors.lastname: Marceau
authors.forename: Frédéric
authors.initials: F
authors.lastname: Picard
mesh_terms: D000328:Adult; D015904:Biliopancreatic Diversion / Q000379:methods*; D001786:Blood Glucose / Q000378:metabolism*; D001823:Body Composition; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D018971:Insulin-Like Growth Factor Binding Protein 2 / Q000097:blood*; D020738:Leptin / Q000097:blood*; D008297:Male; D009767:Obesity, Morbid / Q000097:blood* / Q000378:metabolism / Q000601:surgery; D013997:Time Factors; D014280:Triglycerides / Q000097:blood; D015854:Up-Regulation; D015431:Weight Loss
chemical_list: D001786:Blood Glucose; D007328:Insulin; D018971:Insulin-Like Growth Factor Binding Protein 2; D020738:Leptin; D014280:Triglycerides