title: Safety of gelatin for volume resuscitation--a systematic review and meta-analysis.
abstract: OBJECTIVE
  Gelatin is frequently used as a volume expander in critical care. Our goal was to investigate its safety.
  
  
  METHODS
  Systematic review of randomized controlled trials (RCT) in patients receiving gelatin for resuscitation in comparison to albumin or crystalloids.
  
  
  RESULTS
  We identified 40 RCTs published between 1976 and 2010 with 3,275 patients. Median sample size in the gelatin groups was 15 patients (range 10-249). Median gelatin dose was 17 ml/kg (range 6-57 ml/kg). In 32 RCTs (n = 1,946/3,275, 59 % of all patients), the study period was ≤24.0 h. Twenty-nine RCTs (n = 2,001) investigated elective surgical patients, mostly undergoing cardiac surgery (18 RCTs, n = 819). Three RCTs (n = 723) investigated critically ill adults. Two RCTs (n = 59) were performed in emergency room patients, and six RCTs (n = 492) were performed in neonates or children. No study was adequately powered to investigate the frequency of patient-important outcomes. Risks were not statistically significantly different for mortality (RR 1.12, 95 % confidence interval, 0.87-1.44) and exposure to allogeneic transfusion (RR 1.28, 0.89-1.83). On account of only few included studies and the small number of patients, subgroup analyses (high vs. low dose, >24 h vs. shorter periods, and critically ill patients vs. others) were uninformative. Only three RCTs reported the occurrence of acute renal failure.
  
  
  CONCLUSIONS
  Despite over 60 years of clinical practice, the safety and efficacy of gelatin cannot be reliably assessed in at least some settings in which it is currently used. We suggest the need to investigate and establish such safety.
authors.affiliation: Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Friedrich Schiller University Jena, Erlanger Allee 101, 07747, Jena, Germany.
authors.forename: D O
authors.initials: DO
authors.lastname: Thomas-Rueddel
authors.forename: V
authors.initials: V
authors.lastname: Vlasakov
authors.forename: K
authors.initials: K
authors.lastname: Reinhart
authors.forename: R
authors.initials: R
authors.lastname: Jaeschke
authors.forename: H
authors.initials: H
authors.lastname: Rueddel
authors.forename: R
authors.initials: R
authors.lastname: Hutagalung
authors.forename: A
authors.initials: A
authors.lastname: Stacke
authors.forename: C S
authors.initials: CS
authors.lastname: Hartog
mesh_terms: D000328:Adult; D002648:Child; D005440:Fluid Therapy / Q000379:methods; D005780:Gelatin / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D061214:Patient Safety; D010952:Plasma Substitutes / Q000009:adverse effects / Q000627:therapeutic use*; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D015532:Rehydration Solutions / Q000009:adverse effects / Q000627:therapeutic use*; D012151:Resuscitation / Q000379:methods
chemical_list: D010952:Plasma Substitutes; D015532:Rehydration Solutions; D005780:Gelatin