title: Elevated levels of S100B, tau and pNFH in cerebrospinal fluid are correlated with subtypes of Guillain-Barré syndrome.
abstract: Guillain-Barré syndrome (GBS) is an immune-mediated inflammatory disease in the peripheral nervous system. Specific biomarkers for the two most common clinical subtypes of GBS, i.e., acute inflammatory demyelinating polyneuropathy (AIDP) and acute motor axonal neuropathy (AMAN) are still missing. The distinctive pathological features of AIDP and AMAN may lead to release of such specific biomarkers including glial markers (calcium-binding astroglial protein, S100B) and axonal damage markers [axoskeletal protein, phosphorylated neurofilament heavy protein (pNFH); cytoskeletal protein, tau], etc. To explore the potentials of biochemical markers for differential diagnosis and evaluation of prognosis of clinical subtypes in GBS, we used ELISA to measure the levels of S100B, tau and pNFH in serum and cerebrospinal fluid (CSF) from the patients with AIDP, AMAN, viral encephalitis and other non-inflammatory neurological disorders (OND), respectively. The values of albumin quotient and IgG index in CSF are significantly higher in AIDP and AMAN than in OND. The levels of S100B, tau and pNFH in serum and CSF are elevated in the patients with AIDP and AMAN compared to OND. The concentrations of these proteins are all higher in CSF than in serum. Increased levels of S100B in CSF at the acute phase are positively correlated with the GBS disability scale scores (GDSs) in AIDP, whereas enhanced levels of tau and pNFH in CSF are positively correlated with the GDSs in AMAN. Increased CSF levels of S100B, tau and pNFH at the acute phase may predict a poor prognosis and evaluate the severity of AIDP or AMAN at plateau and the recovery phase. Elevated levels of pNFH in CSF may be used for differentiating between AMAN and AIDP.
authors.affiliation: Department of Neurology, The First Hospital of Jilin University, Changchun, China.
authors.forename: Xiao-Ke
authors.initials: XK
authors.lastname: Wang
authors.forename: Hong-Liang
authors.initials: HL
authors.lastname: Zhang
authors.forename: Fan-Hua
authors.initials: FH
authors.lastname: Meng
authors.forename: Ming
authors.initials: M
authors.lastname: Chang
authors.forename: Yu-Zhi
authors.initials: YZ
authors.lastname: Wang
authors.forename: Tao
authors.initials: T
authors.lastname: Jin
authors.forename: Eilhard
authors.initials: E
authors.lastname: Mix
authors.forename: Jie
authors.initials: J
authors.lastname: Zhu
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000418:Albumins; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D020275:Guillain-Barre Syndrome / Q000097:blood / Q000134:cerebrospinal fluid* / Q000145:classification / Q000503:physiopathology; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D016900:Neurofilament Proteins / Q000097:blood / Q000134:cerebrospinal fluid*; D010766:Phosphorylation; D064568:S100 Calcium Binding Protein beta Subunit / Q000097:blood / Q000134:cerebrospinal fluid*; D012720:Severity of Illness Index; D013223:Statistics as Topic; D055815:Young Adult; D016875:tau Proteins / Q000097:blood / Q000134:cerebrospinal fluid*
chemical_list: D000418:Albumins; D007074:Immunoglobulin G; D016900:Neurofilament Proteins; D064568:S100 Calcium Binding Protein beta Subunit; C579160:S100B protein, human; D016875:tau Proteins; C051774:neurofilament protein H