title: Synthesis of elastic biodegradable polyesters of ethylene glycol and butylene glycol from sebacic acid.
abstract: High molecular weight biodegradable polyesters were prepared from sebacic acid, ethylene glycol and butylene glycol through a simple non-solvent polycondensation with a low toxicity catalyst. The successful synthesis of the polyesters was confirmed by gel permeation chromatography, (1)H-nuclear magnetic resonance and Fourier transform-infrared spectroscopies and differential scanning calorimetry. The degradation tests were performed at 37 °C in phosphate buffer solution (pH 7.4) and showed a mass loss of ~5% over 12 weeks compared with only 2% for polycaprolactone (PCL). Reverse transcription polymerase chain reaction results following culture of osteoblasts on the polymer surface showed that poly(ethylene sebacate) and poly(butylene sebacate) films were optimal for osteoblast formation in terms of Runx 2 and osteocalcin gene expression.
authors.affiliation: Department of Nanobiomedical Science & WCU Research Center, Dankook University Graduate School, Cheonan 330-714, South Korea.
authors.forename: Hyung-seok
authors.initials: HS
authors.lastname: Park
authors.forename: Jung-a
authors.initials: JA
authors.lastname: Seo
authors.forename: Hye-Young
authors.initials: HY
authors.lastname: Lee
authors.forename: Hae-Won
authors.initials: HW
authors.lastname: Kim
authors.forename: Ivan B
authors.initials: IB
authors.lastname: Wall
authors.forename: Myoung-Seon
authors.initials: MS
authors.lastname: Gong
authors.forename: Jonathan C
authors.initials: JC
authors.lastname: Knowles
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001673:Biodegradation, Environmental / Q000187:drug effects; D015415:Biomarkers / Q000378:metabolism; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D002072:Butylene Glycols / Q000737:chemistry*; D003652:Decanoic Acids / Q000737:chemistry*; D003998:Dicarboxylic Acids / Q000737:chemistry*; D055119:Elastic Modulus / Q000187:drug effects; D004548:Elasticity / Q000187:drug effects; D019855:Ethylene Glycol / Q000737:chemistry*; D005786:Gene Expression Regulation / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008422:Materials Testing; D051379:Mice; D008855:Microscopy, Electron, Scanning; D008970:Molecular Weight; D010012:Osteogenesis / Q000187:drug effects / Q000235:genetics; D011091:Polyesters / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D017550:Spectroscopy, Fourier Transform Infrared; D017154:Stromal Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D013499:Surface Properties / Q000187:drug effects; D013696:Temperature; D013718:Tensile Strength / Q000187:drug effects
chemical_list: D001672:Biocompatible Materials; D015415:Biomarkers; D002072:Butylene Glycols; D003652:Decanoic Acids; D003998:Dicarboxylic Acids; D011091:Polyesters; C016240:polycaprolactone; C011107:sebacic acid; D019855:Ethylene Glycol