title: Breast and gynecological cancers in Croatia, 1988-2008.
abstract: OBJECTIVE
  To analyze and interpret incidence and mortality trends of breast and ovarian cancers and incidence trends of cervical and endometrial cancers in Croatia for the period 1988-2008.
  
  
  METHODS
  Incidence data were obtained from the Croatian National Cancer Registry. Themortality data were obtained from the World Health Organization (WHO) mortality database. Trends of incidence and mortality were analysed by joinpoint regression analysis.
  
  
  RESULTS
  Joinpoint analysis showed an increase in the incidence of breast cancer with estimated annual percent of change (EAPC) of 2.6% (95% confidence interval [CI], 1.9 to 3.4). The mortality rate was stable, with the EAPC of 0.3%. Endometrial cancer showed an increasing incidence trend, with EAPC of 0.8% (95% CI, 0.2 to 1.4), while cervical cancer showed a decreasing incidence trend, with EAPC of -1.0 (95% CI, -1.6 to -0.4). Ovarian cancer incidence showed three trends, but the average annual percent change (AAPC) for the overall period was not significant, with a stable trend of 0.1%. Ovarian cancer mortality was increasing since 1992, with EAPC of 1.2% (95% CI, 0.4 to 1.9), while the trend for overall period was stable with AAPC 0.1%.
  
  
  CONCLUSIONS
  Incidence trends of breast, endometrial, and ovarian cancers in Croatia 1988-2008 are similar to the trends observed in most of the European countries, while the modest decline in cervical cancer incidence and lack of decline in breast cancer mortality suggest suboptimal cancer prevention and control.
authors.affiliation: Croatian National Institute of Public Health, Rockefellerova 7, 10000 Zagreb, Croatia.
authors.forename: Iva
authors.initials: I
authors.lastname: Kelava
authors.forename: Karlo
authors.initials: K
authors.lastname: Tomicić
authors.forename: Marina
authors.initials: M
authors.lastname: Kokić
authors.forename: Ante
authors.initials: A
authors.lastname: Corusić
authors.forename: Pavao
authors.initials: P
authors.lastname: Planinić
authors.forename: Iva
authors.initials: I
authors.lastname: Kirac
authors.forename: Jure
authors.initials: J
authors.lastname: Murgić
authors.forename: Tomislav
authors.initials: T
authors.lastname: Kulis
authors.forename: Ariana
authors.initials: A
authors.lastname: Znaor
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000453:epidemiology*; D017523:Croatia / Q000453:epidemiology; D005260:Female; D005833:Genital Neoplasms, Female / Q000453:epidemiology*; D006801:Humans; D008875:Middle Aged; D009017:Morbidity / Q000639:trends; D012189:Retrospective Studies; D015996:Survival Rate / Q000639:trends