title: Platinum nanoparticles reduce ovariectomy-induced bone loss by decreasing osteoclastogenesis.
abstract: Platinum nanoparticles (PtNP) exhibit remarkable antioxidant activity. There is growing evidence concerning a positive relationship between oxidative stress and bone loss, suggesting that PtNP could protect against bone loss by modulating oxidative stress. Intragastric administration of PtNP reduced ovariectomy (OVX)- induced bone loss with a decreased level of activity and number of osteoclast (OC) in vivo. PtNP inhibited OC formation by impairing the receptor activator of nuclear factor-κB ligand (RANKL) signaling. This impairment was due to a decreased activation of nuclear factor-κB and a reduced level of nuclear factor in activated T-cells, cytoplasmic 1 (NFAT2). PtNP lowered RANKL-induced long lasting reactive oxygen species as well as intracellular concentrations of Ca(2+) oscillation. Our data clearly highlight the potential of PtNP for the amelioration of bone loss after estrogen deficiency by attenuated OC formation.
authors.affiliation: Department of Biological Sciences (BK21 Program) and Immunomodulation Research Center, University of Ulsan, Ulsan 680-749, Korea.
authors.forename: Woon-Ki
authors.initials: WK
authors.lastname: Kim
authors.forename: Jin-Chun
authors.initials: JC
authors.lastname: Kim
authors.forename: Hyun-Jung
authors.initials: HJ
authors.lastname: Park
authors.forename: Ok-Joo
authors.initials: OJ
authors.lastname: Sul
authors.forename: Mi-Hyun
authors.initials: MH
authors.lastname: Lee
authors.forename: Ji-Soon
authors.initials: JS
authors.lastname: Kim
authors.forename: Hye-Seon
authors.initials: HS
authors.lastname: Choi
mesh_terms: D000818:Animals; D053768:Metal Nanoparticles / Q000008:administration & dosage*; D051379:Mice; D008810:Mice, Inbred C57BL; D050778:NFATC Transcription Factors / Q000378:metabolism; D010010:Osteoclasts / Q000187:drug effects / Q000502:physiology; D010024:Osteoporosis / Q000188:drug therapy; D010052:Ovariectomy / Q000009:adverse effects; D018384:Oxidative Stress / Q000187:drug effects; D010984:Platinum / Q000008:administration & dosage*; D053245:RANK Ligand / Q000235:genetics / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D050778:NFATC Transcription Factors; C494005:Nfatc1 protein, mouse; D053245:RANK Ligand; D017382:Reactive Oxygen Species; C505689:Tnfsf11 protein, mouse; D010984:Platinum