title: [Protein S, C and antithrombin deficiency: association with myocardial infarction and thromboembolism in the young].
abstract: BACKGROUND
  The pathogenesis of myocardial infarction (MI) in young involves new factors including constitutional or acquired thrombophilia.
  
  
  OBJECTIVE
  To determine in patients ² 50 years, the association between coagulation factors deficiency, myocardial infarction and cardiovascular events during follow-up.
  
  
  METHODS
  Protein C (PC), PS and antithrombin (AT) were screened in 50 patients admitted for acute MI and in a healthy control group. Univariate and multivariate analysis were performed using SPSS 11.5 version.
  
  
  RESULTS
  PS and PC deficiency were associated to MI (respectively 24% vs 0%, p=0.001 and 14% vs 0%, p=0.016), independently for PC. No AT deficiency was detected in both groups. During followup, PS and C deficiency were predictive for venous thrombosis (p<0.05) and PS deficiency for pulmonary embolism.
  
  
  CONCLUSIONS
  Protein C and S deficiency may play an important role in MI in young and also in thromboembolic complications during follow-up. Nevertheless, therapeutic implications remain controversial.
authors.affiliation: Service d'hematologie, Hopital La Rabta, Tunis, Tunisie.
authors.forename: Neila
authors.initials: N
authors.lastname: Ben Romdhane
authors.forename: Hela
authors.initials: H
authors.lastname: Baccouche
authors.forename: Sonia
authors.initials: S
authors.lastname: Ammar
authors.forename: Sonia
authors.initials: S
authors.lastname: Mahjoub
authors.forename: Sonia
authors.initials: S
authors.lastname: Chabrak
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000209:etiology*; D013923:Thromboembolism / Q000209:etiology*; D019851:Thrombophilia / Q000150:complications*; D055815:Young Adult