title: Radical cystectomy over the age of 75 is safe and increases survival.
abstract: BACKGROUND
  Radical cystectomy (RC) is probably underused in elderly patients due to a potential increased postoperative complication risk, as reflected by their considerable comorbidities. Our objective was to estimate the overall complication rate and investigate a potential benefit to patients over the age of 75 subjected to RC in terms of disease-free survival.
  
  
  METHODS
  A total of 81 patients, 61 men and 20 women, from two urological departments, with a mean age of 79.2 ± 3.7 years, participated in the study. The mean follow-up period was 2.6 ± 1.6 years. All patients underwent RC with pelvic lymphadenectomy. An ileal conduit, an orthotopic ileal neobladder and cutaneous ureterostomies were formed in 48.1%, 6.2% and 45.7% of the patients, respectively. The perioperative and 90-day postoperative complications were recorded and classified according to the modified Clavien classification system. Survival plots were created based on the oncological outcome and several study parameters.
  
  
  RESULTS
  The perioperative morbidity rate was 43.2%; the 90-day morbidity rate was 37%, while the 30-day, 90-day and overall mortality rates were 3.7%, 3.7% and 21%, respectively. Overall mortality rates were recorded at the final year of data gathering (2009). Increased age, increased body mass index (BMI), longer hospitalization and age-adjusted Charlson comorbidity index (ACCI) more than six, were associated with greater hazard for 90-day morbidity. The cumulative mortality / metastasis-free rates for one, two, three and five years were 88.7%, 77.5%, 70.4%, and 62.3%, respectively. Tumour stage and positive nodes were prognostic predictors for oncological outcome.
  
  
  CONCLUSIONS
  RC in patients over 75 is justified and feasible, due to acceptable complication rates and high 5-year cancer-specific survival, which support an aggressive approach. Prospective studies are needed for the verification of the above results.
authors.affiliation: Department of Urology, Athens University Medical School, LAIKO Hospital, Athens, Greece. styritzis@med.uoa.gr
authors.forename: Stavros I
authors.initials: SI
authors.lastname: Tyritzis
authors.forename: Ioannis
authors.initials: I
authors.lastname: Anastasiou
authors.forename: Konstantinos G
authors.initials: KG
authors.lastname: Stravodimos
authors.forename: Aristeides
authors.initials: A
authors.lastname: Alevizopoulos
authors.forename: Anastasios
authors.initials: A
authors.lastname: Kollias
authors.forename: Antonios
authors.initials: A
authors.lastname: Balangas
authors.forename: Ioannis
authors.initials: I
authors.lastname: Katafigiotis
authors.forename: Ioannis
authors.initials: I
authors.lastname: Leotsakos
authors.forename: Dionysios
authors.initials: D
authors.lastname: Mitropoulos
authors.forename: Constantinos A
authors.initials: CA
authors.lastname: Constantinides
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015653:Cystectomy / Q000009:adverse effects* / Q000401:mortality; D005260:Female; D006801:Humans; D053208:Kaplan-Meier Estimate; D008297:Male; D011183:Postoperative Complications / Q000453:epidemiology; D016016:Proportional Hazards Models; D016019:Survival Analysis; D001749:Urinary Bladder Neoplasms / Q000401:mortality / Q000601:surgery