title: Detection of KPC-2 and qnrS1 in clinical isolates of Morganella morganii from China.
abstract: Seven carbapenem-nonsusceptible Morganella morganii isolates, which have similar antibiotic susceptibility profiles, were isolated over a 5-month period. MICs of imipenem, meropenem, and ertapenem were 8, 1, and 0.25 to 0.5 μg/mL, respectively. Pulsed-field gel electrophoresis indicated that 6 isolates were indistinguishable or closely related. Carbapenem resistance can be transferred from M. morganii to Escherichia coli by conjugation. All M. morganii isolates and E. coli transconjugants produced KPC-2 and carried the qnrS1 gene. Production of KPC-2 mainly contributed to the carbapenem resistance in M. morganii. KPC-2-producing M. morganii clonally spread in a hospital in China.
authors.affiliation: Second Affiliated Hospital of Zhejiang University, Zhejiang University, Hangzhou, China.
authors.forename: Jia Chang
authors.initials: JC
authors.lastname: Cai
authors.forename: Wei
authors.initials: W
authors.lastname: Yang
authors.forename: Yan Yan
authors.initials: YY
authors.lastname: Hu
authors.forename: Rong
authors.initials: R
authors.lastname: Zhang
authors.forename: Hong Wei
authors.initials: HW
authors.lastname: Zhou
authors.forename: Gong-Xiang
authors.initials: GX
authors.lastname: Chen
mesh_terms: D000368:Aged; D019732:Amide Synthases / Q000032:analysis* / Q000096:biosynthesis / Q000235:genetics; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins / Q000235:genetics; D002681:China; D024881:Drug Resistance, Bacterial; D004756:Enterobacteriaceae Infections / Q000382:microbiology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D017720:Molecular Epidemiology; D020613:Morganella morganii / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism*; D001618:beta-Lactamases / Q000032:analysis* / Q000096:biosynthesis / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; C491478:beta-lactamase KPC-2; D001618:beta-Lactamases; D019732:Amide Synthases