title: Calf thymus DNA binding studies of the new neodymium-naproxen complex.
abstract: Fluorescence spectroscopy in combination with UV absorption spectroscopy was carried out to investigate the interaction between the neodymium-naproxen complex (Nd-NAP) and calf thymus DNA (ctDNA). The experimental results showed that Nd-NAP intercalated with the ctDNA base pairs. Analysis of fluorescence quenching data of Nd-NAP by ctDNA at different temperatures using a Stern-Volmer equation revealed that dynamic and static quenching occurred simultaneously. The binding constants and the number of binding sites at 293 and 310 K were obtained as 2.904 × 10(4) L mol(-1), 1.172 and 2.432 × 10(4) L mol(-1), 1.143, respectively. The thermodynamic parameters ΔG, ΔH, and ΔS calculated at different temperatures indicated that hydrogen bonding and van der Waals force were the main binding forces.
authors.affiliation: School of Chemistry and Environmental Sciences, Henan Normal University, Xinxiang 453007, People's Republic of China.
authors.forename: Ruina
authors.initials: R
authors.lastname: Huo
authors.forename: Guiqing
authors.initials: G
authors.lastname: Xu
authors.forename: Xiaoying
authors.initials: X
authors.lastname: Jiang
authors.forename: Yao
authors.initials: Y
authors.lastname: Ge
authors.forename: Zaikun
authors.initials: Z
authors.lastname: Xue
authors.forename: Fengling
authors.initials: F
authors.lastname: Cui
mesh_terms: D001665:Binding Sites; D004247:DNA / Q000737:chemistry*; D009288:Naproxen / Q000737:chemistry; D009354:Neodymium / Q000737:chemistry; D013050:Spectrometry, Fluorescence; D013056:Spectrophotometry, Ultraviolet; D013816:Thermodynamics
chemical_list: D009354:Neodymium; D009288:Naproxen; D004247:DNA; C427203:calf thymus DNA