title: Absolute configurations of C34 and C35 of antibiotic niphimycin A.
abstract: The relative configurations of four stereogenic centers of the C33-C42 fragment of niphimycin A were assigned as 2S*, 3R*, 4S* and 6S*, based upon (1)H NMR analysis with double-quantum filtered COSY and nuclear Overhauser spectroscopy experiments. These data were then correlated with absolute configurations at C36 and C38 of niphimycin A, which were declared previously as 36S and 38S [3]. This allowed for the assignment of the absolute configurations at C34 and C35 of niphimycin A as 34S and 35R.
authors.affiliation: Department of Pharmaceutical Technology and Biochemistry, Gdańsk University of Technology, Gdańsk, Poland.
authors.forename: Tomasz
authors.initials: T
authors.lastname: Laskowski
authors.forename: Zbigniew
authors.initials: Z
authors.lastname: Rafiński
authors.forename: Paweł
authors.initials: P
authors.lastname: Sowiński
authors.forename: Jan
authors.initials: J
authors.lastname: Pawlak
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry*; D006146:Guanidines / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure
chemical_list: D000900:Anti-Bacterial Agents; D006146:Guanidines; C010492:niphimycin