title: Safety of autologous bone marrow stromal cell transplantation in dogs with acute spinal cord injury.
abstract: OBJECTIVE
  To assess the feasibility and safety of transplantation of autologous bone marrow stromal cell (BMSC) in dogs with acute spinal cord injury (SCI).
  
  
  METHODS
  An open-label single-arm trial.
  
  
  METHODS
  Dogs (n = 7) with severe SCI from T6 to L5, caused by vertebral fracture and luxation.
  
  
  METHODS
  Decompressive and stabilization surgery was performed on dogs with severe SCI caused by vertebral fracture and luxation. Autologous BMSCs were obtained from each dog's femur, cultured, and then injected into the lesion in the acute stage. Adverse events and motor and sensory function were observed for >1 year after SCI.
  
  
  RESULTS
  Follow-up was 29-62 months after SCI. No complications (eg, infection, neuropathic pain, worsening of neurologic function) were observed. Two dogs walked without support, but none of the 7 dogs had any change in sensory function.
  
  
  CONCLUSIONS
  Autologous BMSC transplantation is feasible and safe in dogs with acute SCI. Further studies are needed to determine the efficacy of this therapy.
authors.affiliation: Nakayama Veterinary Hospital, Nara, Japan.
authors.forename: Hidetaka
authors.initials: H
authors.lastname: Nishida
authors.forename: Masanari
authors.initials: M
authors.lastname: Nakayama
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Tanaka
authors.forename: Masahiko
authors.initials: M
authors.lastname: Kitamura
authors.forename: Shingo
authors.initials: S
authors.lastname: Hatoya
authors.forename: Kikuya
authors.initials: K
authors.lastname: Sugiura
authors.forename: Yasuji
authors.initials: Y
authors.lastname: Harada
authors.forename: Yoshihisa
authors.initials: Y
authors.lastname: Suzuki
authors.forename: Chizuka
authors.initials: C
authors.lastname: Ide
authors.forename: Toshio
authors.initials: T
authors.lastname: Inaba
mesh_terms: D000818:Animals; D016026:Bone Marrow Transplantation / Q000009:adverse effects / Q000379:methods / Q000662:veterinary*; D004285:Dogs / Q000293:injuries* / Q000601:surgery*; D005260:Female; D050723:Fractures, Bone / Q000601:surgery / Q000662:veterinary; D008297:Male; D020127:Recovery of Function; D013119:Spinal Cord Injuries / Q000601:surgery / Q000662:veterinary*; D013131:Spine / Q000473:pathology / Q000601:surgery; D017154:Stromal Cells / Q000637:transplantation; D014182:Transplantation, Autologous / Q000662:veterinary; D016896:Treatment Outcome