title: Enantioselective Friedel-Crafts reactions between phenols and N-tosylaldimines catalyzed by a leucine-derived bifunctional catalyst.
abstract: Enantioselective Friedel-Crafts reactions between phenols and N-tosylaldimines were developed using a bifunctional catalyst readily prepared from L-leucine. The chiral benzylic amine products were obtained in high yields (up to 96% yield) and good to high enantiomeric excesses (up to 95% ee).
authors.affiliation: State key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China.
authors.forename: Guo-Xing
authors.initials: GX
authors.lastname: Li
authors.forename: Jin
authors.initials: J
authors.lastname: Qu
mesh_terms: D001596:Benzylamines / Q000138:chemical synthesis*; D002384:Catalysis; D007097:Imines / Q000737:chemistry*; D007930:Leucine / Q000737:chemistry*; D010636:Phenols / Q000737:chemistry*; D013237:Stereoisomerism; D014105:Tosyl Compounds / Q000737:chemistry*
chemical_list: D001596:Benzylamines; D007097:Imines; D010636:Phenols; D014105:Tosyl Compounds; D007930:Leucine