title: [Hepatitis B virus immunoglobulin on demand to prevent infection recurrence among liver allograft recipients: report of three cases].
abstract: Infection recurrence rates among hepatitis B virus infected liver allograft recipients, may be as high as 80%. Immunoprophylaxis with anti HBVgammaglobulin may reduce these rates and improve survival. The dose of anti HBV gammaglobulin that must be used is not clearly defined. The most commonly accepted protocol uses 10,000 units during the anhepatic phase and 10,000 units daily during one week, followed by weekly doses of 10,000 units during one month and maintenance with 10,000 units monthly, without measuring anti hepatitis B surface antigen antibodies (antiHBs). Some reports recommend the use of immunoglobulin on demand, to maintain antiHBs titers between 100 and 250 U/l. The infection recurrence rates among patients treated with immunoglobulin and Lamivudine fluctuates between 0 and 10%, during follow up periods of 13 to 30 months. We report three liver allograft recipients that received immunoglobulin on demand, using a mean of 41,000 units, maintaining adequate antiHBs titers.
authors.affiliation: Sección de Gastroenterología, Servicio Medicina Interna, Hospital Clínico Universidad de Chile, Chile. jaime_poniachik@yahoo.es
authors.forename: Jaime
authors.initials: J
authors.lastname: Poniachik
authors.forename: Carolina
authors.initials: C
authors.lastname: Pizarro
authors.forename: Jorge
authors.initials: J
authors.lastname: Contreras
authors.forename: Javier
authors.initials: J
authors.lastname: Silva
authors.forename: Carmen
authors.initials: C
authors.lastname: Hurtado
authors.forename: Mauricio
authors.initials: M
authors.lastname: Venegas
authors.forename: Jaime
authors.initials: J
authors.lastname: Castillo
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Cardemil
authors.forename: Danny
authors.initials: D
authors.lastname: Oksenberg
authors.forename: José
authors.initials: J
authors.lastname: Ibarra
authors.forename: Angélica
authors.initials: A
authors.lastname: Bórquez
authors.forename: Juan Carlos
authors.initials: JC
authors.lastname: Díaz
mesh_terms: D005260:Female; D006509:Hepatitis B / Q000150:complications / Q000601:surgery*; D006515:Hepatitis B virus / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000008:administration & dosage*; D008103:Liver Cirrhosis / Q000517:prevention & control* / Q000601:surgery / Q000821:virology; D016031:Liver Transplantation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D055502:Secondary Prevention
chemical_list: D007136:Immunoglobulins; C045213:hepatitis B hyperimmune globulin