title: Randomized controlled trial of 0.454% stannous fluoride dentifrice to treat gingival bleeding.
abstract: OBJECTIVE
  To evaluate the effects of a highly bioavailable 0.454% stannous fluoride dentifrice on established gingival bleeding over a 3-month period.
  
  
  METHODS
  A randomized controlled clinical trial was conducted. In total, 100 adults with mild-to-moderate gingivitis and an average of 15 bleeding sites were assigned to either the stannous fluoride or regular control pastes for at-home use. Of these, 99 received study treatment and 97 completed the study.
  
  
  RESULTS
  The stannous fluoride group experienced 50% to 74% reductions in bleeding sites relative to baseline or the control, differing significantly (P < 0.001) at all time points. Most subjects in the stannous fluoride group (94%) had measured improvements in bleeding, and nearly one half completed treatment with one or no bleeding sites.
  
  
  CONCLUSIONS
  These study results suggest that incorporation of this 0.454% stannous fluoride dentifrice into daily oral hygiene maybe expected to yield less gingival bleeding at subsequent dental check-ups, and therefore reduce the risk of progressive periodontal disease.
authors.affiliation: Procter & Gamble, Cincinnati, Ohio, USA.
authors.forename: Robert W
authors.initials: RW
authors.lastname: Gerlach
authors.forename: Pejmon
authors.initials: P
authors.lastname: Amini
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003802:Dentifrices / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D005884:Gingival Hemorrhage / Q000188:drug therapy*; D005891:Gingivitis / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D010512:Periodontal Index; D014002:Tin Fluorides / Q000008:administration & dosage / Q000627:therapeutic use*; D014099:Toothbrushing / Q000379:methods; D055815:Young Adult
chemical_list: D003802:Dentifrices; D014002:Tin Fluorides