title: High-fat taste challenge reveals altered striatal response in women recovered from bulimia nervosa: A pilot study.
abstract: OBJECTIVE
  Individuals with anorexia nervosa (AN) and bulimia nervosa (BN) tend to have disordered thinking and eating behaviours in regards to fat containing foods. This is the first study to investigate neuronal pathways that may contribute to altered fat consumption in eating disordered patients.
  
  
  METHODS
  We used functional magnetic resonance imaging (fMRI) to compare responses to a high-fat cream stimulus, water, and a non-caloric viscous stimulus (CMC) to control for response to viscosity in individuals recovered from AN (N = 15), BN (N = 14) and a healthy control sample (CW, N = 18).
  
  
  RESULTS
  An interaction analysis (ANOVAR) comparing the three groups (AN, BN, CW) and the three conditions (cream, CMC, water) revealed significant differences in the left anterior ventral striatum (AVS). A post hoc analysis displayed a higher magnitude of response for the contrast cream/water in BN compared to AN or CW and for the contrast CMC/water in BN compared to AN.
  
  
  CONCLUSIONS
  BN showed an exaggerated AVS response for the cream/water contrast in comparison to AN or CW. Moreover, BN showed an exaggerated AVS response for the CMC/water contrast in comparison to AN. These findings support the possibility that BN have an altered hedonic and/or motivational drive to consume fats.
authors.affiliation: Department of Child & Adolescent Psychiatry, J.W. Goethe University of Frankfurt , Frankfurt , Germany.
authors.forename: Daniel
authors.initials: D
authors.lastname: Radeloff
authors.forename: Kathrin
authors.initials: K
authors.lastname: Willmann
authors.forename: Lisa
authors.initials: L
authors.lastname: Otto
authors.forename: Michael
authors.initials: M
authors.lastname: Lindner
authors.forename: Karen
authors.initials: K
authors.lastname: Putnam
authors.forename: Sara Van
authors.initials: SV
authors.lastname: Leeuwen
authors.forename: Walter H
authors.initials: WH
authors.lastname: Kaye
authors.forename: Fritz
authors.initials: F
authors.lastname: Poustka
authors.forename: Angela
authors.initials: A
authors.lastname: Wagner
mesh_terms: D000328:Adult; D000856:Anorexia Nervosa / Q000503:physiopathology*; D052018:Bulimia Nervosa / Q000503:physiopathology*; D004041:Dietary Fats / Q000494:pharmacology*; D005260:Female; D059907:Functional Neuroimaging / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D008279:Magnetic Resonance Imaging; D017072:Neostriatum / Q000503:physiopathology*; D010865:Pilot Projects; D013649:Taste / Q000502:physiology*; D066328:Ventral Striatum; D014867:Water / Q000494:pharmacology; D055815:Young Adult
chemical_list: D004041:Dietary Fats; D014867:Water