title: Matching between regional coronary vasodilator capacity and corresponding circumferential strain in individuals with normal and increasing body weight.
abstract: BACKGROUND
  To define the relationship between regional coronary vasodilator capacity and myocardial circumferential strain at rest in normal weight, overweight, and obese individuals with normal global left-ventricular function.
  
  
  RESULTS
  Myocardial blood flow at rest and during pharmacologic vasodilation was measured with (13)N-ammonia PET/CT in mL/g/minute in normal weight control (CON, n = 12), overweight (OW, n = 10), and obese individuals (OB, n = 10). In addition, resting myocardial function was evaluated as circumferential strain (Єc, %) by MRI. Global myocardial flow reserve (MFR) did not differ significantly between CON and OW (2.98 ± 0.96 vs 2.70 ± 0.66, P = .290), whereas it declined significantly in OB (1.98 ± 1.04, P = .030). Further, global Єc (%) was comparable between CON, OW, and OB (-0.24 ± 0.03, -0.23 ± 0.02, and -0.23 ± 0.04) but it was lowest in OB when normalized to the rate-pressure product (NЄc: -0.31 ± 0.06, -0.32 ± 0.05, and -0.26 ± 0.08). When MFR of the three major coronary territories was correlated with corresponding Єc, a positive association was observed in CON (r = 0.36, P = .030), in OW (r = 0.54, P = .002), and also in OB when relating NЄc to coronary vascular resistance during pharmacologic vasodilation (r = -0.46, P = .010).
  
  
  CONCLUSIONS
  Higher coronary vasodilator capacity is related to corresponding regional circumferential strain at rest in non-obese individuals, while this is also observed for reduced MFR in obesity.
authors.affiliation: Division of Cardiology, Nuclear Cardiology and Cardiac PET/CT, Department of Specialities in Medicine, University Hospital of Geneva, Geneva, Switzerland.
authors.forename: Gabriella M
authors.initials: GM
authors.lastname: Vincenti
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Ambrosio
authors.forename: Jean-Noël
authors.initials: JN
authors.lastname: Hyacinthe
authors.forename: Alessandra
authors.initials: A
authors.lastname: Quercioli
authors.forename: Yann
authors.initials: Y
authors.lastname: Seimbille
authors.forename: François
authors.initials: F
authors.lastname: Mach
authors.forename: Osman
authors.initials: O
authors.lastname: Ratib
authors.forename: Jean-Paul
authors.initials: JP
authors.lastname: Vallée
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Schindler
mesh_terms: D000328:Adult; D000368:Aged; D001835:Body Weight; D003326:Coronary Circulation / Q000502:physiology*; D005260:Female; D006339:Heart Rate; D006439:Hemodynamics; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D008955:Models, Cardiovascular; D009206:Myocardium / Q000473:pathology*; D009765:Obesity / Q000628:therapy; D050177:Overweight; D049268:Positron-Emission Tomography / Q000379:methods; D014057:Tomography, X-Ray Computed / Q000379:methods; D014664:Vasodilation / Q000502:physiology*; D014665:Vasodilator Agents / Q000494:pharmacology / Q000627:therapeutic use; D016277:Ventricular Function, Left
chemical_list: D014665:Vasodilator Agents