title: Factors associated with phyllodes tumor of the breast after core needle biopsy identifies fibroepithelial neoplasm.
abstract: BACKGROUND
  Phyllodes tumors represent less than 1% of all breast neoplasms and can mimic fibroadenoma on core needle biopsy (CNB). The treatment of fibroepithelial (FE) neoplasms identified on CNB is controversial. We sought to identify factors that were associated with phyllodes tumors after CNB suggested FE neoplasm.
  
  
  METHODS
  A retrospective database was queried for all patients diagnosed with FE neoplasm on CNB at Ben Taub General Hospital over a 10-y period. One hundred twenty-three patients were identified and demographic, clinical, and outcome data were analyzed.
  
  
  RESULTS
  Of the 123 patients, 46 (37%) were found to have fibroadenomatous features and 59 (48%) were found to have FE features. All went on to have surgical excision. Forty (38%) contained phyllodes tumors, and 65 (62%) found no phyllodes tumor on final pathology. There were significant differences in the median size of the masses (4 cm versus 2.4 cm P < 0.002) and density of the masses (P < 0.001) between the group that contained phyllodes tumors and the group that did not on preoperative imaging. Further evaluation did not show any significant differences on preoperative imaging between benign and borderline/malignant phyllodes tumors. Hispanic ethnicity correlated with a higher chance of phyllodes tumor after CNB (P < 0.001).
  
  
  CONCLUSIONS
  Women commonly present to clinics for evaluation of palpable breast masses. Based on the results of CNB, clinical decisions can be made to help direct treatment. If CNB identifies phyllodes tumor, surgical excision remains the standard of care; however, patients with suspicious FE neoplasms represent a treatment dilemma as many will prove to be benign. Preoperative size and the density of the mass on imaging and ethnicity were associated with phyllodes tumors on final pathology.
authors.affiliation: Medical Scientist Training Program, Baylor College of Medicine, Houston, Texas 77030, USA.
authors.forename: Daniel J
authors.initials: DJ
authors.lastname: Gould
authors.forename: Jessica A
authors.initials: JA
authors.lastname: Salmans
authors.forename: Brian K
authors.initials: BK
authors.lastname: Lassinger
authors.forename: Alejandro
authors.initials: A
authors.lastname: Contreras
authors.forename: Carolina
authors.initials: C
authors.lastname: Gutierrez
authors.forename: Elizabeth
authors.initials: E
authors.lastname: Bonefas
authors.forename: Kathleen R
authors.initials: KR
authors.lastname: Liscum
authors.forename: Eric J
authors.initials: EJ
authors.lastname: Silberfein
mesh_terms: D000328:Adult; D062005:Biopsy, Large-Core Needle / Q000379:methods; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery; D016208:Databases, Factual; D003937:Diagnosis, Differential; D005260:Female; D018226:Fibroadenoma / Q000473:pathology* / Q000601:surgery; D006801:Humans; D009369:Neoplasms / Q000473:pathology* / Q000601:surgery; D003557:Phyllodes Tumor / Q000473:pathology* / Q000601:surgery; D011237:Predictive Value of Tests; D011300:Preoperative Care; D012189:Retrospective Studies