title: Bacterial interactions in the nasopharynx - effects of host factors in children attending day-care centers.
abstract: The nasopharynges of preschool children are often colonized by potentially pathogenic bacteria. The interactions between these common pathogens and certain host factors were investigated in healthy preschool children 1-6 years of age. Nasopharynx samples were collected from all 63 children attending a day-care center that experienced an outbreak of penicillin-resistant Streptococcus pneumoniae. The samples were analyzed for S. pneumoniae, Haemophilus influenzae, Moraxella catarrhalis, and Group A Streptococci. A model for the risk of carrying these bacteria was established using logistic regression. S. pneumoniae and H. influenzae antagonize each other, whereas M. catarrhalis and S. pneumoniae have a positively association. The risk of carrying M. catarrhalis decreases with age. The time spent in day care each week was not shown to influence the rate of carriage of any of these pathogens. The negative effect of H. influenzae on S. pneumoniae is discussed in relation to the carriage of penicillin-resistant S. pneumoniae, and possible mechanisms involved in this interaction are presented.
authors.affiliation: Section of General Practice, Department of Public Health and Research Unit of General Practice, University of Copenhagen, P.O. Box 2099, 1014 Copenhagen, Denmark. lpc525@alumni.ku.dk
authors.forename: Victor
authors.initials: V
authors.lastname: Dahlblom
authors.forename: Margareta
authors.initials: M
authors.lastname: Söderström
mesh_terms: D001419:Bacteria / Q000145:classification / Q000254:growth & development* / Q000302:isolation & purification*; D001424:Bacterial Infections / Q000382:microbiology*; D002353:Carrier State / Q000382:microbiology*; D002648:Child; D002656:Child Day Care Centers; D002675:Child, Preschool; D006193:Haemophilus influenzae; D006801:Humans; D007223:Infant; D008297:Male; D056265:Microbial Interactions; D001936:Moraxella catarrhalis; D009305:Nasopharynx / Q000382:microbiology*; D013291:Streptococcus; D013296:Streptococcus pneumoniae; D013297:Streptococcus pyogenes