title: Detecting and characterizing individual molecules with single nanopores.
abstract: Single-nanometer-scale pores have demonstrated the capability for the detection, identification, and characterization of individual molecules. This measurement method could soon extend the existing commercial instrumentation or provide solutions to niche applications in many fields, including health care and the basic sciences. However, that paradigm shift requires a significantly better understanding of the physics and chemistry that govern the interactions between nanopores and analytes. We describe herein some of our methods and approaches to address this issue.
authors.affiliation: Physical Measurement Laboratory, National Institute of Standards and Technology, Gaithersburg, MD, USA. john.kasianowicz@nist.gov
authors.forename: John J
authors.initials: JJ
authors.lastname: Kasianowicz
authors.forename: Joseph E
authors.initials: JE
authors.lastname: Reiner
authors.forename: Joseph W F
authors.initials: JW
authors.lastname: Robertson
authors.forename: Sarah E
authors.initials: SE
authors.lastname: Henrickson
authors.forename: Claudio
authors.initials: C
authors.lastname: Rodrigues
authors.forename: Oleg V
authors.initials: OV
authors.lastname: Krasilnikov
mesh_terms: D000465:Algorithms; D001426:Bacterial Proteins / Q000737:chemistry*; D001704:Biopolymers / Q000737:chemistry; D002623:Chemistry Techniques, Analytical / Q000379:methods; D017097:Electric Impedance; D004563:Electrochemistry; D006460:Hemolysin Proteins / Q000737:chemistry*; D008567:Membranes, Artificial; D058608:Nanopores; D010316:Particle Size; D017422:Sequence Analysis, DNA / Q000379:methods; D014894:Weights and Measures / Q000295:instrumentation
chemical_list: D001426:Bacterial Proteins; D001704:Biopolymers; D006460:Hemolysin Proteins; D008567:Membranes, Artificial