title: Leptomeningeal carcinomatosis mimicking Creutzfeldt-Jakob disease: clinical features, laboratory tests, MRI images, EEG findings in an autopsy-proven case.
abstract: Leptomeningeal carcinomatosis (LC) refers to diffuse seeding of the leptomeninges by tumor metastases. The clinical presentation may differ and the diagnosis may be difficult especially when cancer has not yet been diagnosed. We report a case of LC, where the clinical picture and a specific change in cerebrospinal fluid suggested the diagnosis of a prion disease.
authors.affiliation: Division of Neurology, S. Antonio Abate Hospital, Trapani, Italy. marghy12@libero.it
authors.forename: Margherita
authors.initials: M
authors.lastname: Francolini
authors.forename: Luigi
authors.initials: L
authors.lastname: Sicurella
authors.forename: Nicolò
authors.initials: N
authors.lastname: Rizzuto
mesh_terms: D001344:Autopsy; D001921:Brain / Q000378:metabolism / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology; D007562:Creutzfeldt-Jakob Syndrome / Q000503:physiopathology*; D004569:Electroencephalography; D005260:Female; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006801:Humans; D007633:Keratins / Q000378:metabolism; D019394:Ki-67 Antigen / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D055756:Meningeal Carcinomatosis / Q000175:diagnosis* / Q000503:physiopathology*; D008875:Middle Aged
chemical_list: D005904:Glial Fibrillary Acidic Protein; D019394:Ki-67 Antigen; D007633:Keratins