title: Chitinase-like proteins in lung injury, repair, and metastasis.
abstract: This report explains how our studies of asthma and Th2 inflammation led us to investigate the roles of chitinase-like proteins (CLPs) in lung injury and repair and puts forth an overall hypothesis that can explain the roles that these moieties play in biology and a hypothesis regarding the ways that dysregulated CLP expression may contribute to the pathogenesis of a variety of diseases. We test this hypothesis by assessing the contributions of the CLP breast regression protein (BRP)-39 in the pathogenesis of malignant melanoma metastasis to the lung.
authors.affiliation: Department of Internal Medicine, Yale School of Medicine, New Haven, CT 06520-8056, USA.
authors.forename: Chun Geun
authors.initials: CG
authors.lastname: Lee
authors.forename: Charles S
authors.initials: CS
authors.lastname: Dela Cruz
authors.forename: Bing
authors.initials: B
authors.lastname: Ma
authors.forename: Farida
authors.initials: F
authors.lastname: Ahangari
authors.forename: Yang
authors.initials: Y
authors.lastname: Zhou
authors.forename: Ruth
authors.initials: R
authors.lastname: Halaban
authors.forename: Mario
authors.initials: M
authors.lastname: Sznol
authors.forename: Jack A
authors.initials: JA
authors.lastname: Elias
mesh_terms: D054392:Adipokines / Q000378:metabolism*; D000818:Animals; D014408:Biomarkers, Tumor / Q000378:metabolism*; D000071451:Chitinase-3-Like Protein 1; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D037102:Lectins / Q000378:metabolism*; D055370:Lung Injury / Q000378:metabolism*; D008175:Lung Neoplasms / Q000378:metabolism* / Q000556:secondary*; D008545:Melanoma / Q000378:metabolism* / Q000473:pathology; D008546:Melanoma, Experimental / Q000378:metabolism / Q000473:pathology; D051379:Mice; D008822:Mice, Transgenic; D009362:Neoplasm Metastasis; D012878:Skin Neoplasms / Q000378:metabolism* / Q000473:pathology
chemical_list: D054392:Adipokines; D014408:Biomarkers, Tumor; C084533:CHI3L1 protein, human; C509289:Chil1 protein, mouse; D000071451:Chitinase-3-Like Protein 1; D006023:Glycoproteins; D037102:Lectins