title: Detection of type-specific antibodies to HSV-1 and HSV-2: comparative analysis of a chemiluminescence immunoassay with a conventional ELISA.
abstract: Type-specific serologic tests for human herpes simplex virus (HSV) are critically important for sexually transmitted disease evaluation. We compared the LIAISON® HSV-1 and HSV-2 Type Specific assays relative to an established commercial ELISA. The overall agreement of the chemiluminescence immunoassay versus the ELISA assay was 99.6% (HSV-1) and 100% (HSV-2). The LIAISON® methodology has several advantages.
authors.affiliation: Immunology Laboratory, Department of Pathology, School of Medicine, Johns Hopkins University, Baltimore, MD 21287, USA.
authors.forename: Amelia W
authors.initials: AW
authors.lastname: Maters
authors.forename: Christina V
authors.initials: CV
authors.lastname: Wright
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Lee
authors.forename: Greta
authors.initials: G
authors.lastname: Schwichtenberg
authors.forename: Barbara
authors.initials: B
authors.lastname: Detrick
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D019411:Clinical Laboratory Techniques / Q000379:methods*; D003124:Colorimetry; D005260:Female; D018259:Herpesvirus 1, Human / Q000276:immunology*; D018258:Herpesvirus 2, Human / Q000276:immunology*; D006801:Humans; D007118:Immunoassay / Q000379:methods; D008163:Luminescent Measurements; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D055815:Young Adult
chemical_list: D000914:Antibodies, Viral