title: A NaYbF4: Tm3+ nanoprobe for CT and NIR-to-NIR fluorescent bimodal imaging.
abstract: Early diagnosis that combines the high-resolutional CT and sensitive NIR-fluorescence bioimaging could provide more accurate information for cancerous tissues, which, however, remain a big challenge. Here we report a simple bimodal imaging platform based on PEGylated NaYbF(4): Tm(3+) nanoparticles (NPs) of less than 20 nm in diameter for both CT and NIR-fluorescence bioimaging. The as-designed nanoprobes showed excellent in vitro and in vivo performances in the dual-bioimaging, very low cytotoxicity and no detectable tissue damage in one month. Remarkably, the Yb(3+) in the lattice of NaYbF(4): Tm(3+) NPs functions not only as a promising CT contrast medium due to its high X-ray absorption coefficiency, but also an excellent sensitizer contributing to the strong NIR-fluorescent emissions for its large NIR absorption cross-section. In addition, these NPs could be easily excreted mainly via feces without detectable remnant in the animal bodies.
authors.affiliation: State Key Laboratory of High Performance Ceramics and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Sciences, 1295 Ding-xi Road, Shanghai 200050, PR China.
authors.forename: Huaiyong
authors.initials: H
authors.lastname: Xing
authors.forename: Wenbo
authors.initials: W
authors.lastname: Bu
authors.forename: Qingguo
authors.initials: Q
authors.lastname: Ren
authors.forename: Xiangpeng
authors.initials: X
authors.lastname: Zheng
authors.forename: Ming
authors.initials: M
authors.lastname: Li
authors.forename: Shengjian
authors.initials: S
authors.lastname: Zhang
authors.forename: Haiyun
authors.initials: H
authors.lastname: Qu
authors.forename: Zheng
authors.initials: Z
authors.lastname: Wang
authors.forename: Yanqing
authors.initials: Y
authors.lastname: Hua
authors.forename: Kuaile
authors.initials: K
authors.lastname: Zhao
authors.forename: Liangping
authors.initials: L
authors.lastname: Zhou
authors.forename: Weijun
authors.initials: W
authors.lastname: Peng
authors.forename: Jianlin
authors.initials: J
authors.lastname: Shi
mesh_terms: D000818:Animals; D016923:Cell Death; D002460:Cell Line; D003287:Contrast Media; D007275:Injections, Intravenous; D051379:Mice; D018613:Microscopy, Confocal; D053758:Nanoparticles / Q000648:ultrastructure; D009928:Organ Specificity; D013050:Spectrometry, Fluorescence / Q000379:methods*; D019265:Spectroscopy, Near-Infrared / Q000379:methods*; D013932:Thulium; D013997:Time Factors; D014018:Tissue Distribution; D014057:Tomography, X-Ray Computed / Q000379:methods*; D051598:Whole Body Imaging; D015018:Ytterbium; D015019:Yttrium
chemical_list: D003287:Contrast Media; D015019:Yttrium; D013932:Thulium; D015018:Ytterbium