title: Evaluation of the effect of disease duration in generalized vitiligo on its clinical response to narrowband ultraviolet B phototherapy.
abstract: OBJECTIVE
  Narrowband ultraviolet B (NB-UVB) has been accepted as an effective therapy for generalized vitiligo. On the other hand, different factors seem to contribute to a good response. The purpose of this study is to evaluate the influence of disease duration on its clinical response to NB-UVB phototherapy.
  
  
  METHODS
  In this open and uncontrolled study, vitiligo was considered 'recent' when the duration of disease was less than or equal to 4 years and 'long standing' when it was greater than 4 years. The patients received NB-UVB thrice weekly with an initial dose of 200 mJ/cm(2) and 10% increments at each subsequent treatment. After categorizing the clinical response to four groups (mild, moderate, good, and excellent), duration of disease and clinical response to NB-UVB were correlated statistically using the t-test.
  
  
  RESULTS
  There were 63 patients: 34 women and 29 men, aged 6-60 years. The mean of disease duration was 10.13 ± 9.1 years. Vitiligo was 'recent' in 26 and 'long standing' in 37 patients. The mean of overall response was 51.94 ± 18.48%. Higher grades of response were more prevalent in patients with recent vitiligo than those with long-standing disease, and there was also statistically significant difference in overall response between these two groups of disease duration (P = 0.023).
  
  
  CONCLUSIONS
  The early treatment of generalized vitiligo may enhance the chance of successful repigmentation.
authors.affiliation: Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran.
authors.forename: Zahra
authors.initials: Z
authors.lastname: Hallaji
authors.forename: Maryam
authors.initials: M
authors.lastname: Ghiasi
authors.forename: Ayat
authors.initials: A
authors.lastname: Eisazadeh
authors.forename: Maede Rayati
authors.initials: MR
authors.lastname: Damavandi
mesh_terms: D000328:Adult; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012880:Skin Pigmentation / Q000528:radiation effects*; D013997:Time Factors; D014467:Ultraviolet Therapy / Q000379:methods*; D014820:Vitiligo / Q000473:pathology / Q000532:radiotherapy*; D055815:Young Adult