title: Improved synthesis of a DNA-dependent protein kinase inhibitor IC86621.
abstract: An improved synthesis of DNA-dependent protein kinase inhibitor, IC86621 is described. This developed method provides an easy access to this simple molecule by using amination, acetylation and Fries rearrangement reactions.
authors.affiliation: Department of Bioinspired Science and Laboratory of Medicinal Chemistry, College of Pharmacy, Ewha Womans University, Seoul, 120-750, Korea.
authors.forename: Girish
authors.initials: G
authors.lastname: Chandra
authors.forename: Varughese
authors.initials: V
authors.lastname: Alexander
authors.forename: Hyuk Woo
authors.initials: HW
authors.lastname: Lee
authors.forename: Lak Shin
authors.initials: LS
authors.lastname: Jeong
mesh_terms: D000098:Acetophenones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000586:Amination; D060326:Chemistry Techniques, Synthetic / Q000379:methods; D051747:DNA-Activated Protein Kinase / Q000037:antagonists & inhibitors*; D015195:Drug Design; D015394:Molecular Structure; D009025:Morpholines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D010636:Phenols / Q000737:chemistry; D047428:Protein Kinase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: C487214:1-(2-hydroxy-4-morpholin-4-ylphenyl)ethanone; D000098:Acetophenones; D009025:Morpholines; D010636:Phenols; D047428:Protein Kinase Inhibitors; D051747:DNA-Activated Protein Kinase; C040659:3-bromophenol