title: Does assisted reproductive technology itself or polycystic ovary syndrome as a cause of infertility have any effect on first trimester serum screening results?
abstract: OBJECTIVE
  To determine whether assisted reproductive technology (ART) itself or polycystic ovary syndrome (PCOS) as a cause of infertility has any effect on first trimester serum screening results.
  
  
  METHODS
  First trimester serum screening results of ART pregnancies of women with PCOS (IVF-P group) were compared with those of women who underwent ART due to malefactor infertility (IVF-H group) and women who conceived spontaneously.
  
  
  RESULTS
  Comparison of the groups for crown-rump length (CRL) and nuchal translucency revealed no significance. There was significant difference between the IVF-H and IVF-P groups in terms of free beta-human chorionic gonadotropin (beta-hCG) levels. Although comparison of groups revealed no significance, pregnancy-associated plasma protein A (PAPP-A) values were higher in the IVF-P group than in the IVF-H group.
  
  
  CONCLUSIONS
  CRL and nuchal translucency measurements were not affected by in vitro fertilization procedures or the presence of maternal PCOS. Use of ART decreased PAPP-A and increased free beta-hCG levels. Although not significant, PAPP-A was higher in PCOS patients who conceived with ART, which may in turn increase false negative rates in these cases.
authors.affiliation: Department of Obstetrics and Gynecology, Fatih University, Faculty of Medicine, Ankara, Turkey.
authors.forename: Aydin
authors.initials: A
authors.lastname: Köşüş
authors.forename: Nermin
authors.initials: N
authors.lastname: Köşüş
authors.forename: Müzeyyen
authors.initials: M
authors.lastname: Duran
authors.forename: Nilgün O
authors.initials: NO
authors.lastname: Turhan
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood; D004314:Down Syndrome / Q000175:diagnosis* / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000209:etiology*; D011085:Polycystic Ovary Syndrome / Q000150:complications*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011261:Pregnancy Trimester, First; D011266:Pregnancy-Associated Plasma Protein-A / Q000378:metabolism; D027724:Reproductive Techniques, Assisted; D012189:Retrospective Studies; D016216:Ultrasonography, Prenatal
chemical_list: D018997:Chorionic Gonadotropin, beta Subunit, Human; D011266:Pregnancy-Associated Plasma Protein-A