title: Axially chiral macrocyclic E-alkene bearing bisazole component formed by sequential C-H homocoupling and ring-closing metathesis.
abstract: Clipping by ring-closing metathesis freezes rotation of a C-C bond to result in forming axial chirality. Treatment of bisbenzimidazole bearing an N-(3-butenyl) substituent with a Grubbs' catalyst undergoes ring-closing metathesis, in which the stereochemistry of the thus formed olefin was exclusively E-form. Analysis by HPLC with a chiral stationary column confirmed clear baseline separation of each enantiomer.
authors.affiliation: Department of Chemical Science and Engineering, Kobe University , 1-1 Rokkodai, Nada, Kobe 657-8501, Japan, and Quantum Beam Science Directorate, Japan Atomic Energy Agency , 1-1-1 Koto, Sayo-cho, Sayo-gun, Hyogo 679-5148, Japan.
authors.forename: Shotaro
authors.initials: S
authors.lastname: Nishio
authors.forename: Takashi
authors.initials: T
authors.lastname: Somete
authors.forename: Atsushi
authors.initials: A
authors.lastname: Sugie
authors.forename: Tohru
authors.initials: T
authors.lastname: Kobayashi
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Yaita
authors.forename: Atsunori
authors.initials: A
authors.lastname: Mori