title: Protection by polyphenols of postprandial human plasma and low-density lipoprotein modification: the stomach as a bioreactor.
abstract: Recent studies dramatically showed that the removal of circulating modified low-density lipoprotein (LDL) results in complete prevention of atherosclerosis. The gastrointestinal tract is constantly exposed to food, some of it containing oxidized compounds. Lipid oxidation in the stomach was demonstrated by ingesting heated red meat in rats. Red wine polyphenols added to the rats' meat diet prevented lipid peroxidation in the stomach and absorption of malondialdehyde (MDA) in rat plasma. In humans, postprandial plasma MDA levels rose by 3-fold after a meal of red meat cutlets. MDA derived from meat consumption caused postprandial plasma LDL modification in human. The levels of plasma MDA showed a 75% reduction by consumption of red wine polyphenols during the meat meal. Locating the main biological site of action of polyphenols in the stomach led to a revision in the understanding of how antioxidants work in vivo and may help to elucidate the mechanism involved in the protective effects of polyphenols in human health.
authors.affiliation: Department of Food Science, ARO , Volcani Center, Bet Dagan, Israel. jokanner@gmail.com
authors.forename: Joseph
authors.initials: J
authors.lastname: Kanner
authors.forename: Shlomit
authors.initials: S
authors.lastname: Gorelik
authors.forename: Sirota
authors.initials: S
authors.lastname: Roman
authors.forename: Ron
authors.initials: R
authors.lastname: Kohen
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008077:Lipoproteins, LDL / Q000097:blood / Q000378:metabolism*; D059808:Polyphenols / Q000378:metabolism / Q000494:pharmacology*; D019518:Postprandial Period / Q000187:drug effects*; D020011:Protective Agents / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D013270:Stomach / Q000187:drug effects
chemical_list: D000975:Antioxidants; D008077:Lipoproteins, LDL; D059808:Polyphenols; D020011:Protective Agents