title: [Expression of JAG1 and DLL1 genes in colorectal cancer and its clinical significance].
abstract: OBJECTIVE
  To study the expression of JAG1 and DLL1 in colorectal cancer and its clinical significance.
  
  
  METHODS
  Patients with colorectal cancer were treated in the Center of Colorectal Surgery of the Third Affiliated Hospital of Nanjing University of TCM were collected prospectively and followed up. A tissue microarray was made and expressions of JAG1 and DLL1 were detected by immunohistochemical staining.
  
  
  RESULTS
  A total of 146 cases with colorectal cancer were included. The differences in JAG1 expression were significant among different tumor differentiation types and the differences in DLL1 expression were significant among different tumor locations(all P<0.05). There were no significant differences in the expression of the two genes and microsatellite instability(MSI)(P>0.05). One hundred and thirty-four (91.8%) cases were followed up and the mean follow-up time was (42.3±13.3) months. Tumor-free survival was noticed in 86 patients. The overall survival was 93% at 1 year, 74% in 3 years, and 67% in 5 years. Multivariate analysis showed that long-term survival rate was related to TMN stage, pathology types, MSI status and expression of JAG1. The prognosis of patients with high expression of JAG1 was better than those with low and negative expression(P<0.05).
  
  
  CONCLUSIONS
  The expressions of JAG1 and DLL1 are related to tumor differentiation and tumor location. The expression of JAG1 gene is associated with long-term survival.
authors.affiliation: Nanjing University of Traditional Chinese Medicine, Jiangsu Integrate Colorectal Oncology Center, Nanjing, China. jinheiying@yahoo.com.cn
authors.forename: Hei-ying
authors.initials: HY
authors.lastname: Jin
authors.forename: Jun-hua
authors.initials: JH
authors.lastname: Xu
authors.forename: Xiao-feng
authors.initials: XF
authors.lastname: Wang
authors.forename: Yi-jiang
authors.initials: YJ
authors.lastname: Ding
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002135:Calcium-Binding Proteins / Q000235:genetics* / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins / Q000235:genetics* / Q000378:metabolism; D000072100:Jagged-1 Protein; D008297:Male; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D053842:Microsatellite Instability; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D000072099:Serrate-Jagged Proteins; D016019:Survival Analysis; D055815:Young Adult
chemical_list: D002135:Calcium-Binding Proteins; C512941:DLK1 protein, human; D036341:Intercellular Signaling Peptides and Proteins; C000606273:JAG1 protein, human; D000072100:Jagged-1 Protein; D008565:Membrane Proteins; D000072099:Serrate-Jagged Proteins