title: The protective effect of yi shen juan bi pill in arthritic rats with castration-induced kidney deficiency.
abstract: Androgens have been linked to the onset, severity, and progression of rheumatoid arthritis (RA). In traditional Chinese medicine (TCM), the most common pattern in RA is kidney deficiency, which partly corresponds to a low sex hormone state. In this study, TCM kidney deficiency was induced in male Sprague-Dawley rats with castration surgery, and a TCM preparation, Yi Shen Juan Bi Pill (YJB), was used to treat collagen induced arthritis (CIA) rats with castration. Metabolomic technique was used to evaluate the pharmacological mechanism in castrated CIA rats treated by YJB. The results showed that castration significantly increased the severity of the arthritis in rats but was ameliorated by YJB. Its pharmacological mechanism was partially associated with lipid metabolites involving free fatty acid (FFA) and lysophosphatidylcholine (LPC). In conclusion, the experimental results demonstrate the protective effect of YJB on the TCM kidney deficiency pattern induced by androgen deficiency in CIA rats and support that YJB should be used for the clinical treatment of RA with TCM kidney deficiency pattern.
authors.affiliation: Institute of Basic Theory of Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China.
authors.forename: Hongyan
authors.initials: H
authors.lastname: Zhao
authors.forename: Jian
authors.initials: J
authors.lastname: Li
authors.forename: Xiaojuan
authors.initials: X
authors.lastname: He
authors.forename: Cheng
authors.initials: C
authors.lastname: Lu
authors.forename: Cheng
authors.initials: C
authors.lastname: Xiao
authors.forename: Xuyan
authors.initials: X
authors.lastname: Niu
authors.forename: Ning
authors.initials: N
authors.lastname: Zhao
authors.forename: Dahong
authors.initials: D
authors.lastname: Ju
authors.forename: Aiping
authors.initials: A
authors.lastname: Lu