title: Kisspeptin-54 levels are increased in patients with colorectal cancer.
abstract: BACKGROUND
  Recent studies have demonstrated that Kisspeptin, the product of the metastasis suppressor gene KiSS-1, could have a role in tumor progression and invasion. In this pilot study, we investigated the association of plasma Kisspeptin-54 level with colorectal cancer (CRC).
  
  
  METHODS
  Plasma Kisspeptin-54 levels were quantified using enzyme-immunoassay (EIA) kits from blood samples of 81 patients with CRC at their initial staging and 59 age-matched healthy controls.
  
  
  RESULTS
  Plasma Kisspeptin-54 levels were significantly higher in CRC patients (86.2 ± 20.5) than in controls (49 ± 12.7; p < 0.005). The cutoff value for Kisspeptin-54 detection was determined as 46 ng/ml, and area under curve (AUC) value was 0.766 with sensitivity 63 %, specificity 81.4 %, positive predictive value 82.2 %, negative predictive value 61.5 %, positive likelihood ratio 3.38, and negative likelihood ratio 0.46. Increased plasma Kisspeptin-54 levels were significantly correlated with nodal involvement of CRC (Spearman, rs = 0.345, p = 0.002). Kisspeptin-54 was also found to be an independent predictive marker for lymph node metastases of CRC (p = 0; Exp(B): 2.053; 95 % CI, 1.255-2.851).
  
  
  CONCLUSIONS
  Our results reveal that plasma Kisspeptin-54 measurement could be a useful diagnostic and prognostic parameter for CRC. Further prospective evaluation is needed to validate these findings and to establish the clinical usefulness of Kisspeptin-54 for CRC diagnostics.
authors.affiliation: National Peritoneal Organization in Tokushukai Hospital, Kishiwada City, Osaka, Japan. dremelcanbay@gmail.com
authors.forename: Emel
authors.initials: E
authors.lastname: Canbay
authors.forename: Arzu
authors.initials: A
authors.lastname: Ergen
authors.forename: Dursun
authors.initials: D
authors.lastname: Bugra
authors.forename: Sumer
authors.initials: S
authors.lastname: Yamaner
authors.forename: Ilhan Yaylim
authors.initials: IY
authors.lastname: Eraltan
authors.forename: Yilmaz
authors.initials: Y
authors.lastname: Buyukuncu
authors.forename: Turker
authors.initials: T
authors.lastname: Bulut
mesh_terms: D000368:Aged; D015179:Colorectal Neoplasms / Q000097:blood / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans; D059648:Kisspeptins / Q000096:biosynthesis / Q000097:blood / Q000235:genetics*; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D012372:ROC Curve
chemical_list: C106628:KISS1 protein, human; D059648:Kisspeptins