title: Colonic perforation induced by short term use of slow release diclofenac.
abstract: Upper gastrointestinal (GI) toxicity of non-steroidal anti-inflammatory drugs (NSAIDs) is well characterized. There is also documented data regarding their adverse effects on lower GI tract, like colonic strictures, inflammatory bowel disease and complications of diverticular disease in the form of abscess or perforation. But there are only two case reports published previously that show colonic perforation due to use of NSAIDs solely. We present here a case of colonic perforation induced by short-term use of slow release diclofenac in a young man. Colonic perforation should be considered as the possible diagnosis in patients with acute abdomen and NSAIDs to be one of the differentials if other possibilities are ruled out.
authors.affiliation: East Surgical Ward, Mayo Hospital, Lahore. drns01@hotmail.com
authors.forename: Noman
authors.initials: N
authors.lastname: Shahzad
authors.forename: Asif
authors.initials: A
authors.lastname: Maqbool
authors.forename: Tooba Mahmud
authors.initials: TM
authors.lastname: Gauhar
authors.forename: Khwaja Muhammad
authors.initials: KM
authors.lastname: Azim
mesh_terms: D000006:Abdomen, Acute / Q000175:diagnosis / Q000209:etiology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000627:therapeutic use; D003106:Colon / Q000601:surgery*; D003692:Delayed-Action Preparations / Q000009:adverse effects* / Q000627:therapeutic use; D004008:Diclofenac / Q000009:adverse effects* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004636:Emergency Service, Hospital; D005500:Follow-Up Studies; D006801:Humans; D007416:Intestinal Perforation / Q000139:chemically induced* / Q000601:surgery; D007813:Laparotomy / Q000379:methods; D008297:Male; D010309:Parotitis / Q000175:diagnosis / Q000188:drug therapy; D018570:Risk Assessment; D016896:Treatment Outcome; D055815:Young Adult
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003692:Delayed-Action Preparations; D004008:Diclofenac