title: Accelerated partial breast irradiation using only intraoperative electron radiation therapy in early stage breast cancer.
abstract: BACKGROUND
  We report the results of a single-institution, phase II trial of accelerated partial breast irradiation (APBI) using a single dose of intraoperative electron radiation therapy (IOERT) in patients with low-risk early stage breast cancer.
  
  
  METHODS
  A cohort of 226 patients with low-risk, early stage breast cancer were treated with local excision and axillary management (sentinel node biopsy with or without axillary node dissection). After the surgeon temporarily reapproximated the excision cavity, a dose of 21 Gy using IOERT was delivered to the tumor bed, with a margin of 2 cm laterally.
  
  
  RESULTS
  With a mean follow-up of 46 months (range, 28-63 months), only 1 case of local recurrence was reported. The observed toxicity was considered acceptable.
  
  
  CONCLUSIONS
  APBI using a single dose of IOERT can be delivered safely in women with early, low-risk breast cancer in carefully selected patients. A longer follow-up is needed to ascertain its efficacy compared to that of the current standard treatment of whole-breast irradiation.
authors.affiliation: Department of Radiation Oncology, University Hospital, Verona, Italy.
authors.forename: Sergio
authors.initials: S
authors.lastname: Maluta
authors.forename: Stefano
authors.initials: S
authors.lastname: Dall'Oglio
authors.forename: Nadia
authors.initials: N
authors.lastname: Marciai
authors.forename: Milena
authors.initials: M
authors.lastname: Gabbani
authors.forename: Zeno
authors.initials: Z
authors.lastname: Franchini
authors.forename: Paolo
authors.initials: P
authors.lastname: Pietrarota
authors.forename: Gabriele
authors.initials: G
authors.lastname: Meliadò
authors.forename: Stefania
authors.initials: S
authors.lastname: Guariglia
authors.forename: Carlo
authors.initials: C
authors.lastname: Cavedon
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001365:Axilla; D001943:Breast Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D002278:Carcinoma in Situ / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D004583:Electrons / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007432:Intraoperative Period; D008197:Lymph Node Excision; D015412:Mastectomy, Segmental / Q000379:methods; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011446:Prospective Studies; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods; D021701:Sentinel Lymph Node Biopsy; D047368:Tumor Burden