title: Invasive Scopulariopsis brevicaulis infection in an immunocompromised patient and review of prior cases caused by Scopulariopsis and Microascus species.
abstract: Scopulariopsis species and their Microascus teleomorphs are cosmopolitan fungi that are uncommonly associated with invasive disease. This report describes a case of fatal disseminated Scopulariopsis brevicaulis disease in a patient with diffuse large B cell lymphoma who underwent high-dose chemotherapy followed by a matched unrelated donor stem cell transplant. This case is compared with 32 prior cases of proven invasive Scopulariopsis (Microascus) infections reported in the literature. A focus of this report is the diagnostic methods utilized which included histopathology and culture with both micromorphologic and genotypic procedures employed to confirm the species identification.
authors.affiliation: Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198-5900, USA. piwen@unmc.edu
authors.forename: Peter C
authors.initials: PC
authors.lastname: Iwen
authors.forename: Stephanie D
authors.initials: SD
authors.lastname: Schutte
authors.forename: Diana F
authors.initials: DF
authors.lastname: Florescu
authors.forename: Rhonda K
authors.initials: RK
authors.lastname: Noel-Hurst
authors.forename: Lynne
authors.initials: L
authors.lastname: Sigler
mesh_terms: D000328:Adult; D001483:Base Sequence; D057210:Delayed Diagnosis; D017809:Fatal Outcome; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D016867:Immunocompromised Host; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy / Q000473:pathology; D008297:Male; D008828:Microbiological Techniques / Q000379:methods; D009181:Mycoses / Q000175:diagnosis / Q000382:microbiology / Q000473:pathology*; D009894:Opportunistic Infections / Q000175:diagnosis / Q000473:pathology; D060645:Scopulariopsis / Q000145:classification / Q000235:genetics / Q000302:isolation & purification* / Q000472:pathogenicity; D017385:Sequence Homology; D016622:Silver Staining / Q000379:methods; D014184:Transplantation, Homologous