title: The correlation between postmenopausal osteoporosis and inflammatory periodontitis regarding bone loss in experimental models.
abstract: We have invented a mouse model of periodontitis associated with alveolar bone loss induced by lipopolysaccharide. Ovariectomized (OVX) animals are widely used as a model for osteoporosis due to estrogen deficiency. To define the relationship between periodontitis and osteoporosis, we examined the influence of estrogen deficiency on the mouse alveolar bone mass. In OVX mice, bone loss was detected not only in the femur, but also in the alveolar bone, indicating that estrogen deficiency could induce resorption in alveolar bone. In experiments using a combination of osteoporosis and periodontitis models, OVX significantly enhanced the alveolar bone loss in the model of periodontitis. Therefore, postmenopausal osteoporosis may enhance the risk of periodontitis associated with inflammatory alveolar bone resorption.
authors.affiliation: Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology, Tokyo 184-8588, Japan.
authors.forename: Megumi
authors.initials: M
authors.lastname: Kobayashi
authors.forename: Chiho
authors.initials: C
authors.lastname: Matsumoto
authors.forename: Michiko
authors.initials: M
authors.lastname: Hirata
authors.forename: Tsukasa
authors.initials: T
authors.lastname: Tominari
authors.forename: Masaki
authors.initials: M
authors.lastname: Inada
authors.forename: Chisato
authors.initials: C
authors.lastname: Miyaura
mesh_terms: D015502:Absorptiometry, Photon; D016301:Alveolar Bone Loss / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D000818:Animals; D015519:Bone Density; D001862:Bone Resorption / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D004195:Disease Models, Animal; D051379:Mice; D008815:Mice, Inbred Strains; D010024:Osteoporosis / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D010052:Ovariectomy; D010518:Periodontitis / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology