title: Projection x-space magnetic particle imaging.
abstract: Projection magnetic particle imaging (MPI) can improve imaging speed by over 100-fold over traditional 3-D MPI. In this work, we derive the 2-D x-space signal equation, 2-D image equation, and introduce the concept of signal fading and resolution loss for a projection MPI imager. We then describe the design and construction of an x-space projection MPI scanner with a field gradient of 2.35 T/m across a 10 cm magnet free bore. The system has an expected resolution of 3.5  ×  8.0 mm using Resovist tracer, and an experimental resolution of 3.8  × 8.4 mm resolution. The system images 2.5 cm  × 5.0 cm partial field-of views (FOVs) at 10 frames/s, and acquires a full field-of-view of 10 cm   × 5.0 cm in 4 s. We conclude by imaging a resolution phantom, a complex "Cal" phantom, mice injected with Resovist tracer, and experimentally confirm the theoretically predicted x-space spatial resolution.
authors.affiliation: Department of Bioengineering, University of California, Berkeley, CA 94720, USA. goodwill@berkeley.edu
authors.forename: Patrick W
authors.initials: PW
authors.lastname: Goodwill
authors.forename: Justin J
authors.initials: JJ
authors.lastname: Konkle
authors.forename: Bo
authors.initials: B
authors.lastname: Zheng
authors.forename: Emine U
authors.initials: EU
authors.lastname: Saritas
authors.forename: Steven M
authors.initials: SM
authors.lastname: Conolly
mesh_terms: D000792:Angiography / Q000379:methods*; D000818:Animals; D001923:Brain Chemistry; D003198:Computer Simulation; D003287:Contrast Media / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D003911:Dextrans / Q000008:administration & dosage / Q000737:chemistry* / Q000493:pharmacokinetics; D008099:Liver / Q000737:chemistry / Q000378:metabolism; D058185:Magnetite Nanoparticles / Q000008:administration & dosage / Q000737:chemistry*; D051379:Mice; D009206:Myocardium / Q000737:chemistry / Q000378:metabolism; D019047:Phantoms, Imaging; D014018:Tissue Distribution
chemical_list: D003287:Contrast Media; D003911:Dextrans; D058185:Magnetite Nanoparticles; C065507:ferumoxides