title: In vitro activities of the new antitubercular agents PA-824 and BTZ043 against Nocardia brasiliensis.
abstract: The in vitro activity of PA-824 and BTZ043 against 30 Nocardia brasiliensis isolates was tested. The MIC(50) and MIC(90) values for PA-824 were both >64 μg/ml. The same values for BTZ043 were 0.125 and 0.250 μg/ml. Given the MIC values for benzothiazinone (BTZ) compounds, we consider them good candidates to be tested in vivo against N. brasiliensis.
authors.affiliation: Laboratorio Interdisciplinario de Investigación Dermatológica, Servicio de Dermatología, Hospital Universitario, Monterrey, NL, Mexico.
authors.forename: Lucio
authors.initials: L
authors.lastname: Vera-Cabrera
authors.forename: Mayra Paola
authors.initials: MP
authors.lastname: Campos-Rivera
authors.forename: Norma Alejandra
authors.initials: NA
authors.lastname: Gonzalez-Martinez
authors.forename: Jorge
authors.initials: J
authors.lastname: Ocampo-Candiani
authors.forename: Stewart T
authors.initials: ST
authors.lastname: Cole
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009593:Nitroimidazoles / Q000494:pharmacology*; D009615:Nocardia / Q000187:drug effects*
chemical_list: D000995:Antitubercular Agents; D009593:Nitroimidazoles; C410767:pretomanid