title: Endometrial abnormality in women with polycystic ovary syndrome.
abstract: Polycystic ovary syndrome (PCOS) is the most common endocrinopathy associated with infertility and metabolic disorder in women of reproductive age. Although the clinical and biochemical features are heterogeneous with individuals, the most widely accepted clinical characteristics of PCOS are oligo- or anovulation combined with hyperandrogenism. With the higher rate of implantation failure after induction of ovulation or higher risk of spontaneous miscarriage after pregnancy, the reduced fertility is apparently attributed not only to anovulation but also to endometrial dysfunction in patients with PCOS. Here we review the features of the endometrial abnormalities in women with PCOS. The ability to improve the endometrial functions is of potential therapeutic targets to increase reproductive outcome of women with PCOS.
authors.affiliation: Department of Physiology and Pathophysiology, Peking University Health Science Center, Beijing, China.
authors.forename: Kewei
authors.initials: K
authors.lastname: Shang
authors.forename: Xiao
authors.initials: X
authors.lastname: Jia
authors.forename: Jie
authors.initials: J
authors.lastname: Qiao
authors.forename: Jihong
authors.initials: J
authors.lastname: Kang
authors.forename: Youfei
authors.initials: Y
authors.lastname: Guan
mesh_terms: D000818:Animals; D016889:Endometrial Neoplasms / Q000209:etiology / Q000517:prevention & control; D004717:Endometrium / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000517:prevention & control; D058990:Molecular Targeted Therapy; D011085:Polycystic Ovary Syndrome / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D011987:Receptors, Steroid / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D011987:Receptors, Steroid