title: Role of advanced glycation endproducts and potential therapeutic interventions in dialysis patients.
abstract: It has been nearly 100 years since the first published report of advanced glycation end products (AGEs) by the French chemist Maillard. Since then, our understanding of AGEs in diseased states has dramatically changed. Especially in the last 25 years, AGEs have been implicated in complications related to aging, neurodegenerative diseases, diabetes, and chronic kidney disease. Although AGE formation has been well characterized by both in vitro and in vivo studies, few prospective human studies exist demonstrating the role of AGEs in patients on chronic renal replacement therapy. As the prevalence of end-stage renal disease (ESRD) in the United States rises, it is essential to identify therapeutic strategies that either delay progression to ESRD or improve morbidity and mortality in this population. This article reviews the role of AGEs, especially those of dietary origin, in ESRD patients as well as potential therapeutic anti-AGE strategies in this population.
authors.affiliation: Division of Nephrology, Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA.
authors.forename: Sandeep K
authors.initials: SK
authors.lastname: Mallipattu
authors.forename: John C
authors.initials: JC
authors.lastname: He
authors.forename: Jaime
authors.initials: J
authors.lastname: Uribarri
mesh_terms: D000818:Animals; D002318:Cardiovascular Diseases / Q000378:metabolism; D003296:Cooking; D048909:Diabetes Complications / Q000378:metabolism; D004195:Disease Models, Animal; D017127:Glycation End Products, Advanced / Q000378:metabolism*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism / Q000628:therapy*; D008567:Membranes, Artificial; D006435:Renal Dialysis
chemical_list: D017127:Glycation End Products, Advanced; D008567:Membranes, Artificial