title: β-Amyrin acetate and β-amyrin palmitate as antidyslipidemic agents from Wrightia tomentosa leaves.
abstract: The ethanolic extract and fractions of Wrightia tomentosa Roem. & Schult (Apocynaceae) leaves were tested in vivo for their antidyslipidemic activity in high fat diet (HFD) induced dyslipidemic hamsters. Activity guided isolation resulted in identification of antidyslipidemic compounds β-AA and β-AP. Compounds β-AA and β-AP decrease the levels of LDL by 36% and 44%, and increase the HDL-C/TC ratio by 49% and 28%, respectively, at a dose of 10mg/kg. In addition, the isolated compounds β-AA and β-AP showed significant HMG-CoA-reductase inhibition, which was further established by docking studies.
authors.affiliation: Medicinal and Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow 226001, India.
authors.forename: Ranjani
authors.initials: R
authors.lastname: Maurya
authors.forename: Anuj
authors.initials: A
authors.lastname: Srivastava
authors.forename: Priyanka
authors.initials: P
authors.lastname: Shah
authors.forename: Mohammad Imran
authors.initials: MI
authors.lastname: Siddiqi
authors.forename: S M
authors.initials: SM
authors.lastname: Rajendran
authors.forename: Anju
authors.initials: A
authors.lastname: Puri
authors.forename: Prem P
authors.initials: PP
authors.lastname: Yadav
mesh_terms: D000818:Animals; D029062:Apocynaceae / Q000737:chemistry*; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D006224:Cricetinae; D059305:Diet, High-Fat / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D050171:Dyslipidemias / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D006903:Hydroxymethylglutaryl CoA Reductases / Q000737:chemistry / Q000378:metabolism; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008297:Male; D008647:Mesocricetus; D008958:Models, Molecular; D015394:Molecular Structure; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D000960:Hypolipidemic Agents; C079349:beta-amyrin palmitate; D009828:Oleanolic Acid; D002784:Cholesterol; C000265:beta-amyrin acetate; D006903:Hydroxymethylglutaryl CoA Reductases