title: Synthesis of 3,5-disubstituted isoxazoles via Cope-type hydroamination of 1,3-dialkynes.
abstract: An efficient method for the synthesis of 3,5-disubstituted isoxazoles is described. The reactions of 1,3-dialkynes with hydroxylamine proceeded smoothly in DMSO under mild reaction conditions to produce 3,5-disubstituted isoxazoles in satisfactory to excellent yields.
authors.affiliation: State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116023, China.
authors.forename: Liangguang
authors.initials: L
authors.lastname: Wang
authors.forename: Xiaoqiang
authors.initials: X
authors.lastname: Yu
authors.forename: Xiujuan
authors.initials: X
authors.lastname: Feng
authors.forename: Ming
authors.initials: M
authors.lastname: Bao
mesh_terms: D000586:Amination; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D003500:Cyclization; D053280:Diynes / Q000737:chemistry*; D007555:Isoxazoles / Q000138:chemical synthesis / Q000737:chemistry; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D053280:Diynes; D007555:Isoxazoles