title: Efficacy of a proapoptotic peptide towards cancer cells.
abstract: BACKGROUND
  Conventional cancer therapies are associated with severe side-effects and the development of drug resistance. Therefore, new strategies to specifically target tumor cells leaving healthy tissue unaffected are of great interest.
  
  
  METHODS
  On this respect, we tested the antimicrobial peptide (KLAKLAK)(2).
  
  
  RESULTS
  This peptide exhibits cytotoxicity against human breast cancer and other tumor cells, while healthy cells remain unaffected. Moreover, treatment with this cationic amphipathic peptide results in slower tumor growth and longer overall survival in vivo.
  
  
  CONCLUSIONS
  Our data suggest a potential use of (KLAKLAK)(2) peptide for patients with breast and other types of cancer.
authors.affiliation: University of Applied Sciences Bonn-Rhein-Sieg, Immunology and Cell Biology, Rheinbach, Germany.
authors.forename: Clara E
authors.initials: CE
authors.lastname: Jäkel
authors.forename: Karoline
authors.initials: K
authors.lastname: Meschenmoser
authors.forename: Young
authors.initials: Y
authors.lastname: Kim
authors.forename: Hans
authors.initials: H
authors.lastname: Weiher
authors.forename: Ingo G H
authors.initials: IG
authors.lastname: Schmidt-Wolf
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D023181:Antimicrobial Cationic Peptides / Q000494:pharmacology* / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D045744:Cell Line, Tumor; D002470:Cell Survival / Q000187:drug effects; D005260:Female; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D047368:Tumor Burden / Q000187:drug effects; D023041:Xenograft Model Antitumor Assays
chemical_list: D023181:Antimicrobial Cationic Peptides; D000970:Antineoplastic Agents