title: In silico drug screen in mouse liver identifies candidate calorie restriction mimetics.
abstract: Calorie restriction (CR) extends life span in mammals and delays the onset of age-related diseases, including cancer and diabetes. Drugs that target the same genes and pathways as CR may have enormous therapeutic potential. Recently, genome-scale data on the responses of human cell lines to over 1,000 drug treatments have become available. Here we integrate these data with gene expression signatures of CR in mouse liver to generate a prioritized list of candidate CR mimetics. We identify 14 drugs that reproduce the effects of CR at the transcriptional level.
authors.affiliation: Department of Medical Biophysics, University of Toronto, Ontario, Canada.
authors.forename: Kristen
authors.initials: K
authors.lastname: Fortney
authors.forename: Eric K
authors.initials: EK
authors.lastname: Morgen
authors.forename: Max
authors.initials: M
authors.lastname: Kotlyar
authors.forename: Igor
authors.initials: I
authors.lastname: Jurisica
mesh_terms: D000818:Animals; D031204:Caloric Restriction / Q000379:methods*; D002460:Cell Line; D002874:Chromosome Mapping; D019295:Computational Biology / Q000379:methods; D004353:Drug Evaluation, Preclinical; D005786:Gene Expression Regulation; D016678:Genome; D015894:Genome, Human; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D051379:Mice; D020411:Oligonucleotide Array Sequence Analysis; D012984:Software; D014158:Transcription, Genetic