title: Extracts of Scutellaria baicalensis reduced body weight and blood triglyceride in db/db Mice.
abstract: Scutellaria baicalensis has been extensively employed for the clinical treatment of hyperlipidemia, atherosclerosis, hypertension, dysentery, inflammatory diseases, and the common cold. The present study was performed to investigate the anti-obesity and anti-dyslipidemia effect of Scutellaria baicalensis extracts (SBE) in type 2 diabetic db/db mice. Male db/db mice were divided into three groups (n = 5) and orally administrated vehicle (control), SBE 10, and 100 mg/kg body weight/day for 4 weeks everyday. Administration of SBE improves weight gain, hypertriglyceridemia, and hyperinsulinemia in db/db mice. In obese db/db mice, SBE treatment also reduced plasma alanine aminotransferase levels. In the livers of db/db mice, SBE promoted 5' AMP-activated protein kinase activity and restored metabolic process and insulin signaling pathways. Our data demonstrate that SBE exerts potent anti-obesity and anti-hypertriglyceride effects suggesting its useful potential function as adjuvant therapeutic agent for the treatment of weight gain and hypertriglyceridemia.
authors.affiliation: Division of constitutional medicine research, Korea Institute of Oriental Medicine, Daejeon, Korea.
authors.forename: Kwang Hoon
authors.initials: KH
authors.lastname: Song
authors.forename: Sun Hwa
authors.initials: SH
authors.lastname: Lee
authors.forename: Bu-Yeo
authors.initials: BY
authors.lastname: Kim
authors.forename: Ah Yeon
authors.initials: AY
authors.lastname: Park
authors.forename: Jong Yeol
authors.initials: JY
authors.lastname: Kim
mesh_terms: D055372:AMP-Activated Protein Kinases / Q000378:metabolism; D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy / Q000378:metabolism; D006949:Hyperlipidemias / Q000188:drug therapy / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000494:pharmacology; D007328:Insulin / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D009765:Obesity / Q000097:blood / Q000188:drug therapy / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology*; D031364:Scutellaria baicalensis / Q000737:chemistry; D014280:Triglycerides / Q000097:blood*
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin; D010936:Plant Extracts; C499814:Scutellaria baicalensis extract; D014280:Triglycerides; D055372:AMP-Activated Protein Kinases