title: The development of a novel dry powder inhaler.
abstract: A novel active and multi-dose dry powder inhaler (DPI) was developed and evaluated to deliver a small quantity (100-500 μg) of pure drug without any excipient. This dry powder inhaler utilized two compressed air flows to dispense and deliver drug powder: the primary flow aerosolizes the drug powder from its pocket and the secondary flow further disperses the aerosol. In vitro tests by Anderson Cascade Impactor (ACI) indicated that the fine particle fraction (FPF) (<4.7 μm) of drug delivery could reach over a range of 50-70% (w/w). Emitted dose tests showed that delivery efficiency was above 85% and its relative standard deviation (RSD) was under 10%. Confocal microscopy was used to confirm the deposition of fluorescently labeled spray-dried powder in rabbit lungs. Also, a chromatographic method was used to quantify drug deposition. The results of animal tests showed that 57% of aerosol deposited in the rabbit lung and 24% deposited in its trachea. All the results implied that this novel active dry powder inhaler could efficiently deliver a small quantity of fine drug particles into the lung with quite high fine particle fraction.
authors.affiliation: Chemical and Biochemical Engineering, University of Western Ontario, 1151 Richmond Street, London N6A 5B9, Canada.
authors.forename: Xi
authors.initials: X
authors.lastname: Zhang
authors.forename: Yingliang
authors.initials: Y
authors.lastname: Ma
authors.forename: Liqiang
authors.initials: L
authors.lastname: Zhang
authors.forename: Jingxu
authors.initials: J
authors.lastname: Zhu
authors.forename: Fang
authors.initials: F
authors.lastname: Jin
mesh_terms: D000336:Aerosols; D000420:Albuterol / Q000008:administration & dosage; D000818:Animals; D058995:Dry Powder Inhalers / Q000295:instrumentation*; D004867:Equipment Design; D016650:Fluorescein-5-isothiocyanate / Q000008:administration & dosage / Q000493:pharmacokinetics; D007328:Insulin / Q000008:administration & dosage; D008168:Lung / Q000378:metabolism; D008297:Male; D009568:Nitrendipine / Q000008:administration & dosage / Q000493:pharmacokinetics; D010316:Particle Size; D010649:Phenylalanine / Q000008:administration & dosage; D011817:Rabbits; D014018:Tissue Distribution; D014132:Trachea / Q000378:metabolism
chemical_list: D000336:Aerosols; D007328:Insulin; D010649:Phenylalanine; D009568:Nitrendipine; D016650:Fluorescein-5-isothiocyanate; D000420:Albuterol