title: Increased program cell death-1 expression on T lymphocytes of patients with progressive multifocal leukoencephalopathy.
abstract: The cellullar immune response is important in the containment of progressive multifocal leukoencephalopathy (PML). We examined program cell death-1 (PD-1) expression, a marker of cellular immune exhaustion, on T lymphocytes in PML. PD-1 expression was elevated on total CD4(+) and CD8(+) T cells (medians 36% and 24%) in PML patients compared with healthy control subjects (medians 14% and 18%; P = 0.0015 and P = 0.033). In PML patients, JC virus (JCV)-specific CD8(+) cytotoxic T lymphocytes expressed PD-1 more frequently than total CD8 T lymphocytes (means 39% and 78%, P = 0.0004). Blocking the PD-1 receptor increased JCV-specific T-cell immune response in a subgroup of PML patients.
authors.affiliation: Department of Medicine, Division of Infectious Diseases, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA. ctan@bidmc.harvard.edu
authors.forename: Chen Sabrina
authors.initials: CS
authors.lastname: Tan
authors.forename: Evelyn
authors.initials: E
authors.lastname: Bord
authors.forename: Thomas A
authors.initials: TA
authors.lastname: Broge
authors.forename: Brett
authors.initials: B
authors.lastname: Glotzbecker
authors.forename: Heidi
authors.initials: H
authors.lastname: Mills
authors.forename: Sarah
authors.initials: S
authors.lastname: Gheuens
authors.forename: Jacalyn
authors.initials: J
authors.lastname: Rosenblatt
authors.forename: David
authors.initials: D
authors.lastname: Avigan
authors.forename: Igor J
authors.initials: IJ
authors.lastname: Koralnik
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000150:complications / Q000276:immunology / Q000821:virology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000821:virology; D016022:Case-Control Studies; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000276:immunology / Q000821:virology; D006801:Humans; D007111:Immunity, Cellular; D007577:JC Virus / Q000276:immunology; D007968:Leukoencephalopathy, Progressive Multifocal / Q000150:complications / Q000276:immunology* / Q000821:virology; D008297:Male; D008875:Middle Aged; D061026:Programmed Cell Death 1 Receptor / Q000037:antagonists & inhibitors / Q000378:metabolism*; D055815:Young Adult
chemical_list: C105992:PDCD1 protein, human; D061026:Programmed Cell Death 1 Receptor