title: Emerging roles for TNIP1 in regulating post-receptor signaling.
abstract: A vast number of cellular processes and signaling pathways are regulated by various receptors, ranging from transmembrane to nuclear receptors. These receptor-mediated processes are modulated by a diverse set of regulatory proteins. TNFα-induced protein 3-interacting protein 1 is such a protein that inhibits both transduction by transmembrane receptors, such as TNFα-receptor, EGF-R, and TLR, and nuclear receptors' PPAR and RAR activity. These receptors play key roles in regulating inflammation and inflammatory diseases. A growing number of references have implicated TNIP1 through GWAS and expression studies in chronic inflammatory diseases such as psoriasis and rheumatoid arthritis, although TNIP1s exact role has yet been determined. In this review, we aim to integrate the current knowledge of TNIP1s functions with the diseases in which it has been associated to potentially elucidate the role this regulator has in promoting or alleviating these inflammatory diseases.
authors.affiliation: Graduate Program in Pharmacology & Toxicology, University of Connecticut, Storrs, CT 06269-3092, USA.
authors.forename: Vincent P
authors.initials: VP
authors.lastname: Ramirez
authors.forename: Igor
authors.initials: I
authors.lastname: Gurevich
authors.forename: Brian J
authors.initials: BJ
authors.lastname: Aneskievich
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology*; D066246:ErbB Receptors / Q000187:drug effects; D055106:Genome-Wide Association Study; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D051379:Mice; D019950:Mitogen-Activated Protein Kinase 1 / Q000037:antagonists & inhibitors; D047492:Peroxisome Proliferator-Activated Receptors / Q000187:drug effects; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D011565:Psoriasis / Q000503:physiopathology; D022661:RNA, Untranslated / Q000502:physiology; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism; D012595:Scleroderma, Systemic / Q000503:physiopathology; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*; D051193:Toll-Like Receptors / Q000187:drug effects
chemical_list: D004268:DNA-Binding Proteins; D047492:Peroxisome Proliferator-Activated Receptors; D022661:RNA, Untranslated; D018160:Receptors, Cytoplasmic and Nuclear; C117046:TNIP1 protein, human; D051193:Toll-Like Receptors; D066246:ErbB Receptors; D019950:Mitogen-Activated Protein Kinase 1