title: Surveillance of transmitted HIV-1 drug resistance in Gauteng and KwaZulu-Natal Provinces, South Africa, 2005-2009.
abstract: Surveillance of human immunodeficiency virus type 1 transmitted drug resistance (TDR) was conducted among pregnant women in South Africa over a 5-year period after the initiation of a large national antiretroviral treatment program. Analysis of TDR data from 9 surveys conducted between 2005 and 2009 in 2 provinces of South Africa suggests that while TDR remains low (<5%) in Gauteng Province, it may be increasing in KwaZulu-Natal, with the most recent survey showing moderate (5%-15%) levels of resistance to the nonnucleoside reverse transcriptase inhibitor drug class.
authors.affiliation: National Institute for Communicable Diseases, Johannesburg, South Africa. gillianh@nicd.ac.za
authors.forename: G M
authors.initials: GM
authors.lastname: Hunt
authors.forename: J
authors.initials: J
authors.lastname: Ledwaba
authors.forename: A E
authors.initials: AE
authors.lastname: Basson
authors.forename: J
authors.initials: J
authors.lastname: Moyes
authors.forename: C
authors.initials: C
authors.lastname: Cohen
authors.forename: B
authors.initials: B
authors.lastname: Singh
authors.forename: S
authors.initials: S
authors.lastname: Bertagnolio
authors.forename: M R
authors.initials: MR
authors.lastname: Jordan
authors.forename: A
authors.initials: A
authors.lastname: Puren
authors.forename: L
authors.initials: L
authors.lastname: Morris
mesh_terms: D000293:Adolescent; D000328:Adult; D044966:Anti-Retroviral Agents / Q000494:pharmacology*; D024882:Drug Resistance, Viral; D005260:Female; D060005:Genotyping Techniques; D015658:HIV Infections / Q000453:epidemiology* / Q000635:transmission* / Q000821:virology; D015497:HIV-1 / Q000145:classification* / Q000187:drug effects / Q000235:genetics; D006801:Humans; D011159:Population Surveillance; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology / Q000821:virology; D012189:Retrospective Studies; D013019:South Africa / Q000453:epidemiology
chemical_list: D044966:Anti-Retroviral Agents