title: A genome-wide association study identifies susceptibility loci for Wilms tumor.
abstract: Wilms tumor is the most common renal malignancy of childhood. To identify common variants that confer susceptibility to Wilms tumor, we conducted a genome-wide association study in 757 individuals with Wilms tumor (cases) and 1,879 controls. We evaluated ten SNPs in regions significantly associated at P < 5 × 10(-5) in two independent replication series from the UK (769 cases and 2,814 controls) and the United States (719 cases and 1,037 controls). We identified clear significant associations at 2p24 (rs3755132, P = 1.03 × 10(-14); rs807624, P = 1.32 × 10(-14)) and 11q14 (rs790356, P = 4.25 × 10(-15)). Both regions contain genes that are plausibly related to Wilms tumorigenesis. We also identified candidate association signals at 5q14, 22q12 and Xp22.
authors.affiliation: Division of Genetics & Epidemiology, Institute of Cancer Research, Sutton, UK.
authors.forename: Clare
authors.initials: C
authors.lastname: Turnbull
authors.forename: Elizabeth R
authors.initials: ER
authors.lastname: Perdeaux
authors.forename: David
authors.initials: D
authors.lastname: Pernet
authors.forename: Arlene
authors.initials: A
authors.lastname: Naranjo
authors.forename: Anthony
authors.initials: A
authors.lastname: Renwick
authors.forename: Sheila
authors.initials: S
authors.lastname: Seal
authors.forename: Rosa Maria
authors.initials: RM
authors.lastname: Munoz-Xicola
authors.forename: Sandra
authors.initials: S
authors.lastname: Hanks
authors.forename: Ingrid
authors.initials: I
authors.lastname: Slade
authors.forename: Anna
authors.initials: A
authors.lastname: Zachariou
authors.forename: Margaret
authors.initials: M
authors.lastname: Warren-Perry
authors.forename: Elise
authors.initials: E
authors.lastname: Ruark
authors.forename: Mary
authors.initials: M
authors.lastname: Gerrard
authors.forename: Juliet
authors.initials: J
authors.lastname: Hale
authors.forename: Martin
authors.initials: M
authors.lastname: Hewitt
authors.forename: Janice
authors.initials: J
authors.lastname: Kohler
authors.forename: Sheila
authors.initials: S
authors.lastname: Lane
authors.forename: Gill
authors.initials: G
authors.lastname: Levitt
authors.forename: Mabrook
authors.initials: M
authors.lastname: Madi
authors.forename: Bruce
authors.initials: B
authors.lastname: Morland
authors.forename: Veronica
authors.initials: V
authors.lastname: Neefjes
authors.forename: James
authors.initials: J
authors.lastname: Nicholson
authors.forename: Susan
authors.initials: S
authors.lastname: Picton
authors.forename: Barry
authors.initials: B
authors.lastname: Pizer
authors.forename: Milind
authors.initials: M
authors.lastname: Ronghe
authors.forename: Michael
authors.initials: M
authors.lastname: Stevens
authors.forename: Heidi
authors.initials: H
authors.lastname: Traunecker
authors.forename: Charles A
authors.initials: CA
authors.lastname: Stiller
authors.forename: Kathy
authors.initials: K
authors.lastname: Pritchard-Jones
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Dome
authors.forename: Paul
authors.initials: P
authors.lastname: Grundy
authors.forename: Nazneen
authors.initials: N
authors.lastname: Rahman
mesh_terms: D002880:Chromosomes, Human, Pair 11; D002889:Chromosomes, Human, Pair 2; D020022:Genetic Predisposition to Disease; D055106:Genome-Wide Association Study; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D009396:Wilms Tumor / Q000235:genetics*