title: Replication: DNA building block synthesis on demand.
abstract: Correct regulation of DNA nucleotide biosynthesis is emerging as a key issue of importance for genome integrity. The fission yeast Spd1 protein can modulate the activity of ribonucleotide reductase (RNR) by at least three different mechanisms. Now a paper reports that Spd1 turnover is linked to ongoing DNA synthesis.
authors.affiliation: Cell cycle and Genome Stability Group, Department of Biology, University of Copenhagen, Ole Maaløes vej 5, DK-2200 Copenhagen N, Denmark.
authors.forename: Christian
authors.initials: C
authors.lastname: Holmberg
authors.forename: Olaf
authors.initials: O
authors.lastname: Nielsen
mesh_terms: D048868:Adaptor Proteins, Signal Transducing / Q000378:metabolism*; D018797:Cell Cycle Proteins / Q000378:metabolism*; D004271:DNA, Fungal / Q000096:biosynthesis*; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism*; D012264:Ribonucleotide Reductases / Q000378:metabolism*; D029702:Schizosaccharomyces pombe Proteins / Q000378:metabolism*
chemical_list: D048868:Adaptor Proteins, Signal Transducing; C506543:Cdt2 protein, S pombe; D018797:Cell Cycle Proteins; D004271:DNA, Fungal; D018809:Proliferating Cell Nuclear Antigen; D029702:Schizosaccharomyces pombe Proteins; C102445:Spd1 protein, S pombe; D012264:Ribonucleotide Reductases