title: Quantitative ultrasound criteria for risk stratification in clinical practice: a comparative assessment.
abstract: This study aimed to compare two different classifications of the risk of fracture/osteoporosis (OP) based on quantitative ultrasound (QUS). Analyses were based on data from the Epidemiological Study on the Prevalence of Osteoporosis, a cross-sectional study conducted in 2000 aimed at assessing the risk of OP in a representative sample of the Italian population. Subjects were classified into 5 groups considering the cross-classification found in previous studies; logistic regression models were defined separately for women and men to study the fracture risk attributable to groups defined by the cross-classification, adjusting for traditional risk factors. Eight-thousand six-hundred eighty-one subjects were considered in the analyses. Logistic regression models revealed that the two classifications seem to be able to identify a common core of individuals at low and at high risk of fractures, and the importance of a multidimensional assessment in older patients to evaluate clinical risk factors together with a simple, inexpensive, radiation-free device such as QUS.
authors.affiliation: CNR, Institute of Neuroscience-Aging Branch, Padova, Italy. marianna.noale@in.cnr.it
authors.forename: Marianna
authors.initials: M
authors.lastname: Noale
authors.forename: Stefania
authors.initials: S
authors.lastname: Maggi
authors.forename: Stefano
authors.initials: S
authors.lastname: Gonnelli
authors.forename: Federica
authors.initials: F
authors.lastname: Limongi
authors.forename: Silvia
authors.initials: S
authors.lastname: Zanoni
authors.forename: Sabina
authors.initials: S
authors.lastname: Zambon
authors.forename: Renzo
authors.initials: R
authors.lastname: Rozzini
authors.forename: Gaetano
authors.initials: G
authors.lastname: Crepaldi
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D058866:Osteoporotic Fractures / Q000000981:diagnostic imaging* / Q000453:epidemiology*; D015995:Prevalence; D015203:Reproducibility of Results; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D014463:Ultrasonography / Q000706:statistics & numerical data*