title: [Immunogenetics of type 1 diabetes mellitus--from fundamental ideas to medical practice].
abstract: The review of studies of Russian researchers on theoretical and practical aspects of genetic predisposition to type 1 diabetes associated with immunity: HLA and not HLA genes. Most important for practical public health outcomes are evidence that HLA-genetic predisposition to type 1 diabetes is associated with the DRB1-genotype, consisting entirely of variants DRB1-genes associated with the development of T1D. It was also established that CTLA4 gene has an independent predictive value for T1D.
authors.forename: L P
authors.initials: LP
authors.lastname: Alekseev
authors.forename: I I
authors.initials: II
authors.lastname: Dedov
authors.forename: R M
authors.initials: RM
authors.lastname: Khaitov
authors.forename: M N
authors.initials: MN
authors.lastname: Boldyreva
authors.forename: D Iu
authors.initials: DIu
authors.lastname: Trofimov
authors.forename: V A
authors.initials: VA
authors.lastname: Peterkova
authors.forename: T L
authors.initials: TL
authors.lastname: Kuraeva
authors.forename: D D
authors.initials: DD
authors.lastname: Abramov
mesh_terms: D003922:Diabetes Mellitus, Type 1 / Q000175:diagnosis / Q000235:genetics / Q000276:immunology; D056726:Genetic Association Studies; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing / Q000379:methods*; D006684:HLA-DR Antigens / Q000235:genetics / Q000276:immunology; D006801:Humans; D055261:Immunogenetic Phenomena; D008285:Major Histocompatibility Complex / Q000235:genetics / Q000276:immunology; D010375:Pedigree; D011110:Polymorphism, Genetic / Q000276:immunology; D011237:Predictive Value of Tests
chemical_list: D006684:HLA-DR Antigens