title: On the biocompatibility between TiO2 nanotubes layer and human osteoblasts.
abstract: Titanium and its alloys are the most popular biomaterials replacing hard tissues in implant surgeries. Clinicians are generally pleased by titanium mechanical properties and non-toxicity performances; on the other hand, there have been reported several cases of titanium implantation failure, phenomenon explained sometimes as "non adherence of human tissue to the metallic surface." Yet, researchers reported that titanium surfaces are favorable for osteoblasts adhesion. Therefore, titanium integration into the human body remains an unsolved problem. In the present study, biocompatibility tests were performed on titanium and TiO(2) nanotubes substrates, involving human bone marrow cells. The combination of a newly developed analytical model based on the hybrid interphase concept, applicable to systems consisting of inert materials when in contact with living tissues, together with experimental results, confirmed previous research studies and lead to the conclusion that osteoblasts adhere efficiently to titanium surfaces. However, the present results suggest that osteoblasts strong anchorage at the very first moment of their contact with the metallic material leads to their apoptosis. It is most probable that in several cases this is the reason of failed implantation surgeries involving titanium.
authors.affiliation: Department of Mechanical and Aeronautical Engineering, University of Patras, Patras 26500, Greece.
authors.forename: Diana V
authors.initials: DV
authors.lastname: Portan
authors.forename: Anthi A
authors.initials: AA
authors.lastname: Kroustalli
authors.forename: Despina D
authors.initials: DD
authors.lastname: Deligianni
authors.forename: George C
authors.initials: GC
authors.lastname: Papanicolaou
mesh_terms: D002448:Cell Adhesion / Q000187:drug effects; D002478:Cells, Cultured; D006801:Humans; D007399:Interphase / Q000187:drug effects; D008422:Materials Testing / Q000379:methods*; D008875:Middle Aged; D043942:Nanotubes / Q000737:chemistry* / Q000648:ultrastructure; D010006:Osteoblasts / Q000166:cytology* / Q000187:drug effects* / Q000648:ultrastructure; D011554:Pseudopodia / Q000187:drug effects / Q000648:ultrastructure; D014025:Titanium / Q000494:pharmacology*
chemical_list: C009495:titanium dioxide; D014025:Titanium