title: Technological progress in generation of induced pluripotent stem cells for clinical applications.
abstract: Reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) is achieved by viral-mediated transduction of defined transcription factors. Generation of iPSCs is of great medical interest as they have the potential to be a source of patient-specific cells. For the eventual goal of clinical application, it is necessary to overcome the limitations of low reprogramming efficiency and chromosomal abnormalities due to viral DNA integration. In this paper, we summarize the current state of reprogramming technology for generation of iPSCs and also discuss potential approaches to the development of safe iPSCs for personalized cell-based replacement therapy.
authors.affiliation: Department of Biomedical Science, College of Health Science, Korea University, Jeongneung-dong, Sungbuk-gu, Seoul 136-703, Republic of Korea.
authors.forename: Seung-Ick
authors.initials: SI
authors.lastname: Oh
authors.forename: Chang Kyu
authors.initials: CK
authors.lastname: Lee
authors.forename: Kyung Jin
authors.initials: KJ
authors.lastname: Cho
authors.forename: Kyung-Ok
authors.initials: KO
authors.lastname: Lee
authors.forename: Ssang-Goo
authors.initials: SG
authors.lastname: Cho
authors.forename: Sunghoi
authors.initials: S
authors.lastname: Hong
mesh_terms: D006801:Humans; D053652:Nuclear Transfer Techniques; D039904:Pluripotent Stem Cells / Q000166:cytology*; D014157:Transcription Factors / Q000502:physiology
chemical_list: D014157:Transcription Factors