title: Liver tumours, toxic hepatitis, intestinal failure-associated liver disease in children.
abstract: Liver cancers in children are primitive (hepatoblastoma, fibrolamellar hepatocarcinoma, sarcomas), or arise on a genetic or viral disease. Their treatment is a combination of chemotherapy (hepatoblastoma) and surgery. Neonatal hemangioendotheliomas may induce heart failure. They are now successfully treated with propranolol. Focal nodular hyperplasia is the most frequent benign tumour in older children and adolescents. Drug hepatotoxicity is not very frequent. Antipyretic drugs may induce severe side effects. Liver failure due to valproic acid is diagnostic of a respiratory chain disorder. The liver side effects of antituberculous and antiretroviral drugs should be monitored. Intestinal failure-associated liver disease is common and can be prevented or treated. Early referral to a specialized centre is important for the prognosis.
authors.affiliation: Hôpital Necker-Enfants-malades, Hepatogastroenterology-nutrition unit, 149, rue de Sèvres, 75015 Paris, France. florence.lacaille@nck.aphp.fr
authors.forename: Florence
authors.initials: F
authors.lastname: Lacaille
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects; D019980:Amoxicillin-Potassium Clavulanate Combination / Q000009:adverse effects; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D044966:Anti-Retroviral Agents / Q000009:adverse effects; D000927:Anticonvulsants / Q000009:adverse effects; D000995:Antitubercular Agents / Q000009:adverse effects; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D002648:Child; D006801:Humans; D007410:Intestinal Diseases / Q000150:complications*; D008107:Liver Diseases / Q000209:etiology*; D008113:Liver Neoplasms / Q000473:pathology* / Q000628:therapy; D009145:Mushroom Poisoning
chemical_list: D018712:Analgesics, Non-Narcotic; D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D044966:Anti-Retroviral Agents; D000927:Anticonvulsants; D000995:Antitubercular Agents; D000082:Acetaminophen; D019980:Amoxicillin-Potassium Clavulanate Combination