title: Flavonoids preservation and release by methacrylic acid-grafted (N-vinyl-pyrrolidone).
abstract: BACKGROUND
  Flavonoids preservation and release.
  
  
  OBJECTIVE
  Synthesis of a polymeric material able to prevent thermal and photo degradation of a flavonoid model compound, such as (+)-catechin, and suitable for a controlled/sustained delivery of this molecule in gastro-intestinal simulating fluids.
  
  
  METHODS
  Methacrylic acid (MAA) was grafted onto poly(N-vinyl-pyrrolidone) (PVP) by a free radical grafting procedure involving a single-step reaction at room temperature. For this purpose, hydrogen peroxide/ascorbic acid redox pair was employed as water-soluble and biocompatible initiator system.
  
  
  CONCLUSIONS
  FT-IR spectra confirmed the insertion of MAA onto the polymeric chain. Stability studies, performed under various conditions, such as freeze-thaw cycles, exposure to strong light, thermal stability studies under constant humidity and with light protection at different temperatures, showed the preservative properties of the polymeric material towards flavonoids. Furthermore, the biocompatibility was highlighted by Hen's Egg Test-Chorioallantoic Membrane assay and in vitro release studies demonstrated the possibility to employ PVP-MAA copolymer as a device for gastro-intestinal release of flavonoids.
  
  
  CONCLUSIONS
  The coupling of good preservative properties together with biocompatibility and the usefulness as carrier in controlled release make this kind of material very interesting from an industrial point of view for different applications in food, pharmaceutical, and cosmetic fields.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università della Calabria, Edificio Polifunzionale, Arcavacata di Rende, Italy. ortensiailaria.parisi@unical.it
authors.forename: Ortensia Ilaria
authors.initials: OI
authors.lastname: Parisi
authors.forename: Francesco
authors.initials: F
authors.lastname: Puoci
authors.forename: Francesca
authors.initials: F
authors.lastname: Iemma
authors.forename: Manuela
authors.initials: M
authors.lastname: Curcio
authors.forename: Giuseppe
authors.initials: G
authors.lastname: Cirillo
authors.forename: Umile Gianfranco
authors.initials: UG
authors.lastname: Spizzirri
authors.forename: Nevio
authors.initials: N
authors.lastname: Picci
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry; D002642:Chick Embryo; D004337:Drug Carriers / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods; D005419:Flavonoids / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000737:chemistry; D008689:Methacrylates / Q000737:chemistry*; D011109:Polymethacrylic Acids / Q000138:chemical synthesis / Q000737:chemistry*; D011145:Polyvinyls / Q000737:chemistry*; D011759:Pyrrolidines / Q000737:chemistry*; D011760:Pyrrolidinones / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D001672:Biocompatible Materials; D004337:Drug Carriers; D005419:Flavonoids; D008689:Methacrylates; D011109:Polymethacrylic Acids; D011145:Polyvinyls; D011759:Pyrrolidines; D011760:Pyrrolidinones; C505150:poly(N-vinylpyrrolidine); D014867:Water; C008384:methacrylic acid; C042670:N-vinyl-2-pyrrolidinone; D006861:Hydrogen Peroxide; D001205:Ascorbic Acid