title: CREG mediated adventitial fibroblast phenotype modulation: a possible therapeutic target for proliferative vascular disease.
abstract: Proliferative vascular diseases, of which neointimal formation is a key pathological feature, cause significant morbidity and mortality worldwide. Adventitia is the outermost connective tissue that surrounds an artery. In recent years, accumulating data indicate that adventitial fibroblasts participate in the formation of neointimal lesions. Our previous studies have demonstrated that cellular repressor of E1A-stimulated genes (CREG) plays critical roles in reducing neointimal hyperplasia by promoting vascular smooth muscle cell (VSMC) differentiation and grow arrest and inhibiting migration. Hence, it is plausible that genetical modification with CREG gene in adventitial fibroblasts might inhibit angiotensin II-induced transdifferentiation to myofibroblasts, proliferation and migration, as well as adventitial thickening, finally decreasing neointimal formation. Possible mechanisms may include CREG direct attenuation of reactive oxygen species derived from reduced cathepsin-dependent activation of NADPH oxidase and indirect suppression of the downstream of NADPH oxidase including ERK1/2, JNK and p38 MAPK pathways in adventitial fibroblasts. Therefore, CREG may be a potential therapeutic target for proliferative vascular diseases.
authors.affiliation: Cardiovascular Research Institute and Department of Cardiology, Shenyang Northern Hospital, 83 Wenhua Road, 110840 Shenyang, China. yalinghan@gmail.com
authors.forename: Yang
authors.initials: Y
authors.lastname: Li
authors.forename: Cheng-Hui
authors.initials: CH
authors.lastname: Yan
authors.forename: Ya-Ling
authors.initials: YL
authors.lastname: Han
mesh_terms: D005347:Fibroblasts / Q000166:cytology; D006801:Humans; D008962:Models, Theoretical; D010641:Phenotype; D012097:Repressor Proteins / Q000235:genetics / Q000502:physiology*; D014652:Vascular Diseases / Q000473:pathology / Q000628:therapy*
chemical_list: C114068:CREG1 protein, human; D012097:Repressor Proteins