title: Handling the limit of detection by extrapolation.
abstract: A general method of estimation with a variable observed subject to a limit of detection is introduced. It is based on extrapolation of the estimates obtained by increasing the limit of detection. Theoretical arguments support the method in some special cases, and it is explored by simulations. Several examples are presented and adaptations for other kinds of censoring explored.
authors.affiliation: SNTL and UPF, Barcelona, Spain. NTL@sntl.co.uk
authors.forename: Nicholas T
authors.initials: NT
authors.lastname: Longford
mesh_terms: D016604:Aflatoxin B1 / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000633:toxicity; D000704:Analysis of Variance; D056808:Biostatistics / Q000379:methods*; D018890:Chemoprevention; D003627:Data Interpretation, Statistical; D006801:Humans; D057230:Limit of Detection; D016014:Linear Models; D015233:Models, Statistical; D011719:Pyrazines / Q000494:pharmacology; D016032:Randomized Controlled Trials as Topic / Q000706:statistics & numerical data; D012044:Regression Analysis; D013871:Thiones; D013876:Thiophenes
chemical_list: D011719:Pyrazines; D013871:Thiones; D013876:Thiophenes; C026209:oltipraz; D016604:Aflatoxin B1