title: Assessing nanoparticle toxicity.
abstract: Nanoparticle toxicology, an emergent field, works toward establishing the hazard of nanoparticles, and therefore their potential risk, in light of the increased use and likelihood of exposure. Analytical chemists can provide an essential tool kit for the advancement of this field by exploiting expertise in sample complexity and preparation as well as method and technology development. Herein, we discuss experimental considerations for performing in vitro nanoparticle toxicity studies, with a focus on nanoparticle characterization, relevant model cell systems, and toxicity assay choices. Additionally, we present three case studies (of silver, titanium dioxide, and carbon nanotube toxicity) to highlight the important toxicological considerations of these commonly used nanoparticles.
authors.affiliation: Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455, USA.
authors.forename: Sara A
authors.initials: SA
authors.lastname: Love
authors.forename: Melissa A
authors.initials: MA
authors.lastname: Maurer-Jones
authors.forename: John W
authors.initials: JW
authors.lastname: Thompson
authors.forename: Yu-Shen
authors.initials: YS
authors.lastname: Lin
authors.forename: Christy L
authors.initials: CL
authors.lastname: Haynes
mesh_terms: D000818:Animals; D006801:Humans; D053758:Nanoparticles / Q000737:chemistry / Q000633:toxicity*; D037742:Nanotubes, Carbon / Q000737:chemistry / Q000633:toxicity*; D012834:Silver / Q000737:chemistry / Q000633:toxicity*; D014025:Titanium / Q000737:chemistry / Q000633:toxicity*; D018675:Toxicity Tests / Q000379:methods*
chemical_list: D037742:Nanotubes, Carbon; C009495:titanium dioxide; D012834:Silver; D014025:Titanium