title: Regenerative wound healing in acute degree III mandibular defects in dogs.
abstract: OBJECTIVE
  To evaluate the healing events in degree III furcation defects in dogs following the application of the combination of an enamel matrix derivative with a biphasic calcium phosphate (Emdogain Plus).
  
  
  METHODS
  Seventeen degree III furcation defects, 5 mm high and 4 mm wide, were created in 9 dogs. In both groups, the defects were conditioned with EDTA. One defect was treated with Emdogain Plus (n = 9), while the contralateral defect serving as control remained empty (n = 8). The defects in both groups were fully covered by coronally repositioned flaps. After 5 months of healing, histologic and histometric analysis was preformed.
  
  
  RESULTS
  A significant amount of new attachment and bone formation was observed in both control and test specimens. However, in a number of control specimens, ankylosis was also observed. In the control and test groups, respectively, the mean new cementum length was 10.8 ± 2.1 mm and 8.6 ± 3.2 mm; the mean periodontal ligament length was 7.6 ± 3.8 mm and 8.1 ± 4.0 mm. The mean new bone height was 4.4 ± 1.3 mm and 4.3 ± 1.6 mm in the control and test groups, respectively. No statistical differences were found between the two groups in terms of amount of cementum, periodontal ligament, and alveolar bone regeneration.
  
  
  CONCLUSIONS
  The present study failed to show higher amounts of newly formed cementum and bone following treatment of acute degree III mandibular furcation defects following use of Emdogain Plus compared with a coronally advanced flap. Emdogain Plus seems to have a protective role against ankylosis in this type of defect.
authors.affiliation: Periodontology Unit, Eastman Dental Institute, University College London, UK. n.mardas@eastman.ucl.ac.uk
authors.forename: Nikos
authors.initials: N
authors.lastname: Mardas
authors.forename: Michael
authors.initials: M
authors.lastname: Kraehenmann
authors.forename: Michel
authors.initials: M
authors.lastname: Dard
mesh_terms: D000539:Alveolar Process / Q000473:pathology; D000818:Animals; D001641:Bicuspid / Q000187:drug effects / Q000473:pathology; D001861:Bone Regeneration / Q000502:physiology; D018786:Bone Substitutes / Q000627:therapeutic use*; D002614:Chelating Agents / Q000627:therapeutic use; D003094:Collagen; D003739:Dental Cementum / Q000473:pathology; D003746:Dental Enamel Proteins / Q000627:therapeutic use*; D004285:Dogs; D004492:Edetic Acid / Q000627:therapeutic use; D005260:Female; D017823:Furcation Defects / Q000145:classification / Q000601:surgery*; D005881:Gingiva / Q000473:pathology; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006882:Hydroxyapatites / Q000627:therapeutic use*; D008336:Mandibular Diseases / Q000145:classification / Q000601:surgery*; D010012:Osteogenesis / Q000502:physiology; D010513:Periodontal Ligament / Q000473:pathology; D011183:Postoperative Complications; D011897:Random Allocation; D013524:Surgical Flaps; D013997:Time Factors; D020254:Tooth Ankylosis / Q000209:etiology / Q000473:pathology; D014092:Tooth Root / Q000187:drug effects; D014945:Wound Healing / Q000502:physiology
chemical_list: D018786:Bone Substitutes; D002614:Chelating Agents; D003746:Dental Enamel Proteins; D006882:Hydroxyapatites; C109069:enamel matrix proteins; C074950:hydroxyapatite-beta tricalcium phosphate; D003094:Collagen; D004492:Edetic Acid