title: Folate-targeting magnetic core-shell nanocarriers for selective drug release and imaging.
abstract: One of the most urgent medical requirements for cancer diagnosis and treatment is how to construct a multifunctional vesicle for simultaneous diagnostic imaging and therapeutic applications. In our study, superparamagnetic iron oxide nanocrystals (SPIONs) and doxorubicin hydrochloride (DOX) are co-encapsulated into PLGA/polymeric liposome core-shell nanocarriers for achieving simultaneous magnetic resonance imaging and targeting drug delivery. The core-shell nanocarrier was self-assembled from a hydrophobic PLGA core and a hydrophilic folate coated PEGlated lipid shell. The experiment showed that folate-targeting magnetic core-shell nanocarriers show clear core-shell structure, excellent magnetism and controlled drug release behavior. Importantly, the core-shell nanoparticles achieve the possibility of co-delivering drugs and SPIONs to the same cells for enhancing magnetic resonance imaging (MRI) effect and improving drug delivery efficiency simultaneously. Our data suggests that the folate-targeting magnetic core-shell nanocarriers (FMNs) could provide effective cancer-targeting and MRI as well as drug delivery. The FMNs may become a useful nanomedical carrier system for cancer diagnosis and treatment.
authors.affiliation: Institute of Nanobiotechnology, School of Materials Science and Engineering, Tianjin University and Tianjin Key Laboratory of Composites and Functional Materials, Tianjin 300072, PR China.
authors.forename: Hanjie
authors.initials: H
authors.lastname: Wang
authors.forename: Sheng
authors.initials: S
authors.lastname: Wang
authors.forename: Zhenyu
authors.initials: Z
authors.lastname: Liao
authors.forename: Peiqi
authors.initials: P
authors.lastname: Zhao
authors.forename: Wenya
authors.initials: W
authors.lastname: Su
authors.forename: Ruifang
authors.initials: R
authors.lastname: Niu
authors.forename: Jin
authors.initials: J
authors.lastname: Chang
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism*; D002626:Chemistry, Pharmaceutical; D003287:Contrast Media / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism; D003692:Delayed-Action Preparations; D004317:Doxorubicin / Q000008:administration & dosage / Q000737:chemistry / Q000378:metabolism*; D004337:Drug Carriers; D005260:Female; D005492:Folic Acid / Q000737:chemistry / Q000378:metabolism*; D006367:HeLa Cells; D006801:Humans; D057927:Hydrophobic and Hydrophilic Interactions; D007700:Kinetics; D019344:Lactic Acid / Q000737:chemistry*; D008055:Lipids / Q000737:chemistry*; D008279:Magnetic Resonance Imaging; D058185:Magnetite Nanoparticles; D036103:Nanotechnology; D010316:Particle Size; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D012995:Solubility; D013499:Surface Properties; D013678:Technology, Pharmaceutical / Q000379:methods; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis / Q000378:metabolism
chemical_list: D000903:Antibiotics, Antineoplastic; D003287:Contrast Media; D003692:Delayed-Action Preparations; D004337:Drug Carriers; D008055:Lipids; D058185:Magnetite Nanoparticles; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D004317:Doxorubicin; D005492:Folic Acid