title: Association between obesity, hypertriglyceridemia and low hepatitis B viral load.
abstract: OBJECTIVE
  This study aimed to investigate the metabolic risk factors of high hepatitis B viral load.
  
  
  METHODS
  Large-scale, community-based cross-sectional study.
  
  
  METHODS
  A total of 3587 hepatitis B virus (HBV)-infected participants without liver cirrhosis at study entry were investigated. High HBV viral load was defined as a serum level 10(4) copies per ml for hepatitis B e antigen (HBeAg) seronegatives or 10(8) copies per ml for HBeAg seropositives.
  
  
  RESULTS
  Among HBeAg seropositives (n=545), high HBV viral load was reversely associated with extreme obesity (odds ratio (OR), 0.30; 95% confidence interval (CI), 0.13-0.68; P=0.004) or central obesity (OR, 0.53; 95% CI, 0.34-0.82; P=0.004) after adjustment for gender, hypertriglyceridemia, hyperuricemia and history of hypertension. High HBV viral load remained significantly inversely associated with extreme obesity (OR, 0.17; 95% CI, 0.05-0.63; P=0.008) and central obesity (OR, 0.44; 95% CI, 0.25-0.78; P=0.005) in male HBeAg-seropositive participants in stratification analyses by gender. Among HBeAg seronegatives (n=3042), however, high HBV viral load was inversely associated with hypertriglyceridemia (OR, 0.74; 95% CI, 0.61-0.89, P=0.002) after adjustment for age, gender, high serum alanine aminotransferase level, and extreme obesity or central obesity. High HBV viral load was still inversely associated with hypertriglyceridemia in both female (OR, 0.70; 95% CI, 0.50-0.97; P=0.041) and male (OR, 0.75; 95% CI, 0.60-0.94; P=0.011) HBeAg-seronegative participants.
  
  
  CONCLUSIONS
  Extreme obesity and central obesity were associated with a low prevalence of high HBV viral load in HBeAg seropositives, especially in men; while hypertriglyceridemia was associated with a low prevalence of high viral load in HBeAg seronegatives in both women and men.
authors.affiliation: Department of Community and Family Medicine, National Taiwan University Hospital, Yun-Lin Branch, Yun-Lin, Taiwan.
authors.forename: C-H
authors.initials: CH
authors.lastname: Chiang
authors.forename: H-I
authors.initials: HI
authors.lastname: Yang
authors.forename: C-L
authors.initials: CL
authors.lastname: Jen
authors.forename: S-N
authors.initials: SN
authors.lastname: Lu
authors.forename: L-Y
authors.initials: LY
authors.lastname: Wang
authors.forename: S-L
authors.initials: SL
authors.lastname: You
authors.forename: J
authors.initials: J
authors.lastname: Su
authors.forename: U H
authors.initials: UH
authors.lastname: Iloeje
authors.forename: C-J
authors.initials: CJ
authors.lastname: Chen
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D003430:Cross-Sectional Studies; D004279:DNA, Viral; D005260:Female; D006509:Hepatitis B / Q000097:blood* / Q000453:epidemiology / Q000276:immunology; D006513:Hepatitis B e Antigens / Q000097:blood*; D006515:Hepatitis B virus / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D015228:Hypertriglyceridemia / Q000097:blood* / Q000453:epidemiology / Q000276:immunology; D008297:Male; D008875:Middle Aged; D056128:Obesity, Abdominal / Q000097:blood* / Q000453:epidemiology / Q000276:immunology; D009767:Obesity, Morbid / Q000097:blood* / Q000453:epidemiology / Q000276:immunology; D016017:Odds Ratio; D015995:Prevalence; D012307:Risk Factors; D013624:Taiwan / Q000453:epidemiology; D019562:Viral Load
chemical_list: D004279:DNA, Viral; D006513:Hepatitis B e Antigens; D000410:Alanine Transaminase