title: [Vitamin D and cancer: antineoplastic effects of 1α,25(OH)2-vitamin D3].
abstract: The hormonal form of vitamin D, 1α,25(OH)2-vitamin D3 (1α,25(OH)2D3), in addition of playing a central role in the control of calcium homeostasis in the body, regulates the growth and differentiation of different cell types, including cancer cells. At present several epidemiologic and clinical studies investigate the effect of the hormone in these cells due to the interest in the therapeutic use of 1α,25(OH)2D3 and analogues with less calcemic activity for prevention or treatment of cancer. This review describes vitamin D endocrine system, its mechanism of action, its antineoplastic activity and provides information about the latest advances in the study of new hormone analogues with less calcemic activity for cancer treatment.
authors.affiliation: Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur, Bahía Blanca, Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina.
authors.forename: Verónica
authors.initials: V
authors.lastname: González Pardo
authors.forename: Ricardo
authors.initials: R
authors.lastname: Boland
authors.forename: Ana
authors.initials: A
authors.lastname: Russo de Boland
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002118:Calcium / Q000378:metabolism; D004703:Endocrine System / Q000187:drug effects / Q000502:physiology; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy* / Q000517:prevention & control; D014807:Vitamin D / Q000494:pharmacology / Q000502:physiology / Q000627:therapeutic use*
chemical_list: D000970:Antineoplastic Agents; D014807:Vitamin D; D002118:Calcium