title: [Immune reconstitution syndrome].
abstract: The immune reconstitution inflammatory syndrome (IRIS) represents a heterogeneous group of conditions. Whilst they typically present in HIV-infected patients with advanced immunodeficiency, IRIS have also been described in HIV-negative patients with immune reconstitution due to other causes of immunosuppression. Frequently IRIS results from an immune response against underlying infection (pathogen-associated IRIS). However, IRIS might become evident during immune reconstitution without an underlying pathogen such as a sarcoid-like illness or an autoimmune thyropathy. Here we report on the epidemiology and risk factors of IRIS along with diagnosis and management of this clinically important inflammatory syndrome.
authors.affiliation: Klinik für Immunologie und Rheumatologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland. meyer-olson.dirk@mh-hannover.de
authors.forename: D
authors.initials: D
authors.lastname: Meyer-Olson
authors.forename: D
authors.initials: D
authors.lastname: Ernst
authors.forename: M
authors.initials: M
authors.lastname: Stoll
mesh_terms: D015658:HIV Infections / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D006801:Humans; D054019:Immune Reconstitution Inflammatory Syndrome / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*