title: Investigation of the haemodynamic environment of bifurcation plaques within the left coronary artery in realistic patient models based on CT images.
abstract: The aim of this study was to investigate the plaques at the left coronary artery (LCA) and their effect on the haemodynamic and wall shear stress (WSS) in realistic patient models. Three sample patients with left coronary disease were selected based on CT data. The plaques were present at the left anterior descending and left circumflex branches with more than 50 % lumen narrowing. Computational fluid dynamics analysis was used to perform simulation of patient-specific models with realistic physiological conditions that demonstrate in vivo cardiac flow. WSS and blood flow in the LCA were measured during cardiac cycles. Our results showed that WSS was found to increase at the stenotic locations and decrease at pre- and post-plaque locations, whilst the recirculation location was found at post-plaque regions. There is a strong correlation between coronary bifurcation plaques and hemodynamic and WSS changes, based on the realistic coronary disease models.
authors.affiliation: Department of Imaging and Applied Physics, Curtin University, Perth, WA, Australia.
authors.forename: Thanapong
authors.initials: T
authors.lastname: Chaichana
authors.forename: Zhonghua
authors.initials: Z
authors.lastname: Sun
authors.forename: James
authors.initials: J
authors.lastname: Jewkes
mesh_terms: D001783:Blood Flow Velocity; D001794:Blood Pressure; D003198:Computer Simulation; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000503:physiopathology*; D003326:Coronary Circulation; D003331:Coronary Vessels / Q000503:physiopathology*; D006801:Humans; D008875:Middle Aged; D008955:Models, Cardiovascular; D033081:Shear Strength