title: Malaria resurgence: a systematic review and assessment of its causes.
abstract: BACKGROUND
  Considerable declines in malaria have accompanied increased funding for control since the year 2000, but historical failures to maintain gains against the disease underscore the fragility of these successes. Although malaria transmission can be suppressed by effective control measures, in the absence of active intervention malaria will return to an intrinsic equilibrium determined by factors related to ecology, efficiency of mosquito vectors, and socioeconomic characteristics. Understanding where and why resurgence has occurred historically can help current and future malaria control programmes avoid the mistakes of the past.
  
  
  METHODS
  A systematic review of the literature was conducted to identify historical malaria resurgence events. All suggested causes of these events were categorized according to whether they were related to weakened malaria control programmes, increased potential for malaria transmission, or technical obstacles like resistance.
  
  
  RESULTS
  The review identified 75 resurgence events in 61 countries, occurring from the 1930s through the 2000s. Almost all resurgence events (68/75 = 91%) were attributed at least in part to the weakening of malaria control programmes for a variety of reasons, of which resource constraints were the most common (39/68 = 57%). Over half of the events (44/75 = 59%) were attributed in part to increases in the intrinsic potential for malaria transmission, while only 24/75 (32%) were attributed to vector or drug resistance.
  
  
  CONCLUSIONS
  Given that most malaria resurgences have been linked to weakening of control programmes, there is an urgent need to develop practical solutions to the financial and operational threats to effectively sustaining today's successful malaria control programmes.
authors.affiliation: Clinton Health Access Initiative, Boston, MA, USA. jcohen@clintonhealthaccess.org
authors.forename: Justin M
authors.initials: JM
authors.lastname: Cohen
authors.forename: David L
authors.initials: DL
authors.lastname: Smith
authors.forename: Chris
authors.initials: C
authors.lastname: Cotter
authors.forename: Abigail
authors.initials: A
authors.lastname: Ward
authors.forename: Gavin
authors.initials: G
authors.lastname: Yamey
authors.forename: Oliver J
authors.initials: OJ
authors.lastname: Sabot
authors.forename: Bruno
authors.initials: B
authors.lastname: Moonen
mesh_terms: D003140:Communicable Disease Control / Q000379:methods*; D021821:Communicable Diseases, Emerging / Q000453:epidemiology*; D006801:Humans; D008288:Malaria / Q000453:epidemiology* / Q000517:prevention & control