title: Low-level laser therapy on the treatment of oral and cutaneous pemphigus vulgaris: case report.
abstract: Pemphigus vulgaris is a chronic autoimmune mucocutaneous disease that initially is manifested by painful intraoral erosions and ulcers which spread to other mucosa and the skin, generally more than 5 months after oral lesion manifestation. The treatment consists of prednisone alone or in combination with an immunosuppressive agent, and the clinical response is perceived within 2 to 4 weeks. Low-level laser therapy has been effective in accelerating the healing of injured tissue, thus inducing cell proliferation and increasing ATP, nucleic acid, and collagen synthesis. We reported two cases of pemphigus vulgaris that received systemic treatment associated with low-level laser therapy for oral and cutaneous lesions. We observed prompt analgesic effect in oral lesions and accelerated healing of oral and cutaneous wounds. Therefore, the present report suggests LLLT as a noninvasive technique that should be considered as an adjuvant therapy in oral and skin disorders in patients with PV.
authors.affiliation: Department of Dermatology and Radiotherapy, Botucatu School of Medicine of São Paulo State University-UNESP, Distrito de Rubião Júnior s/n, 18 618-000, Botucatu, SP, Brazil. eminicucci@hotmail.com
authors.forename: Eliana Maria
authors.initials: EM
authors.lastname: Minicucci
authors.forename: Hélio Amante
authors.initials: HA
authors.lastname: Miot
authors.forename: Silvia Regina Catharino Sartori
authors.initials: SR
authors.lastname: Barraviera
authors.forename: Luciana
authors.initials: L
authors.lastname: Almeida-Lopes
mesh_terms: D000328:Adult; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D028022:Low-Level Light Therapy; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy; D009061:Mouth Mucosa / Q000473:pathology; D010392:Pemphigus / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy*; D011241:Prednisone / Q000008:administration & dosage; D018714:Radiotherapy, Adjuvant; D014945:Wound Healing / Q000528:radiation effects
chemical_list: D007166:Immunosuppressive Agents; D011241:Prednisone