title: The A118G single-nucleotide polymorphism of human μ-opioid receptor gene and use of labor analgesia.
abstract: The human µ-opioid receptor (MOR) is the major site of action of endogenous opioids and most of the clinically used opioid analgesics. The single-nucleotide polymorphism (SNP), A118G of the MOR 1 gene (OPRM1), has been associated with altered pain perception. The aim of this study was to investigate whether this polymorphism of OPRM1 is associated with a number of pain-related behaviors during labor. In this observational retrospective population-based study, pregnant women (n = 814) were recruited at gestational week 18. A plasma sample was collected from each participant and an SNP genotyping assay was performed. No differences in sociodemographic variables or labor pain-related outcomes, such as stage of cervical dilation on arrival at the delivery unit or use of any type of second-line analgesia during spontaneous labor, were found between noncarriers and G-allele carriers of OPRM1. We conclude that there is no association between the A118G polymorphism of OPRM1 regarding pain-related behavior during labor.
authors.affiliation: Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden. fatimah.dabo@kbh.uu.se
authors.forename: Fatimah Dabo
authors.initials: FD
authors.lastname: Pettersson
authors.forename: Alfhild
authors.initials: A
authors.lastname: Grönbladh
authors.forename: Fred
authors.initials: F
authors.lastname: Nyberg
authors.forename: Inger
authors.initials: I
authors.lastname: Sundström-Poromaa
authors.forename: Helena
authors.initials: H
authors.lastname: Åkerud
mesh_terms: D000328:Adult; D000701:Analgesics, Opioid / Q000494:pharmacology / Q000627:therapeutic use*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D048949:Labor Pain / Q000188:drug therapy / Q000453:epidemiology / Q000235:genetics*; D010147:Pain Measurement / Q000187:drug effects / Q000379:methods; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D011159:Population Surveillance / Q000379:methods; D011247:Pregnancy; D017450:Receptors, Opioid, mu / Q000235:genetics*; D012189:Retrospective Studies; D055815:Young Adult
chemical_list: D000701:Analgesics, Opioid; D017450:Receptors, Opioid, mu