title: Effects of vitamin E administration on Plasmodium berghei induced pathological changes and oxidative stress in mice.
abstract: The effects of daily intraperitoneal doses of 1000 i.u/kg body weight of vitamin E   on the course of Plasmodium berghei NK 65 infection and the parasite-induced anemia as   well as alterations in the relative weight of some selected organs and antioxidant status in   mice were investigated. The number of parasitized red cells were not initially affected by the   vitamin administration but were persistently lowered after 11th day post infection to the   termination of the experiment. The P. berghei infection was found to induce anemia, significantly   (P<0.05) increased the relative weight of liver, spleen and kidney but significantly decreased   (P<0.05) the relative brain weight. However, all the parasite-induced changes in these   parameters were significantly (P<0.05) ameliorated by the vitamin administration. Furthermore,   malonydialdehyde concentration in the serum, liver and brain of infected animals was   significantly (P<0.05) increased whereas superoxide dismutase and catalase activities were   significantly (P<0.05) decreased by the infection. But vitamin E administration was found to,   a significant degree (P<0.05), reversed the disease-induced alterations in these oxidative   stress markers. It was concluded that vitamin E at the dose and route used prevented P.   berghei induced anemia as well as alterations in relative organ weight and antioxidant status   in mice.
authors.affiliation: Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria. mauwalibrahim@gmail.com
authors.forename: M A
authors.initials: MA
authors.lastname: Ibrahim
authors.forename: M M B
authors.initials: MM
authors.lastname: Zuwahu
authors.forename: M B
authors.initials: MB
authors.lastname: Isah
authors.forename: I D
authors.initials: ID
authors.lastname: Jatau
authors.forename: A B
authors.initials: AB
authors.lastname: Aliyu
authors.forename: I A
authors.initials: IA
authors.lastname: Umar
mesh_terms: D000740:Anemia / Q000473:pathology; D000825:Animal Structures / Q000473:pathology; D000818:Animals; D007274:Injections, Intraperitoneal; D008288:Malaria / Q000188:drug therapy* / Q000469:parasitology / Q000473:pathology*; D008297:Male; D051379:Mice; D018384:Oxidative Stress / Q000187:drug effects*; D010962:Plasmodium berghei / Q000472:pathogenicity*; D014810:Vitamin E / Q000008:administration & dosage*
chemical_list: D014810:Vitamin E