title: Protective effect of tannins from Ficus racemosa in hypercholesterolemia and diabetes induced vascular tissue damage in rats.
abstract: OBJECTIVE
  To evaluate the protective effect of tannins from Ficus racemosa (F. racemosa) on the lipid profile and antioxidant parameters in high fat meal and streptozotocin induced hypercholesteremia associated diabetes model in rats.
  
  
  METHODS
  The crude tannin fraction was separated from the acetone (70% v/v) bark extract of F. racemosa. Oral administration of tannin fraction (TF) (100 & 200 mg/kg body weight) to rats fed with high fat meal for 30 days (4% cholesterol, 1% cholic acid, 0.5% egg albumin) and injected with streptozotocin (35 mg/kg i.p. in citrate buffer on 14th day).
  
  
  RESULTS
  The administration of TF significantly reverse the increased blood glucose, total cholesterol, triglycerides, low density lipoprotein and also significantly restored the insulin and high density lipoprotein in the serum. In addition tannins significantly restored the activity of antioxidant enzymes such as superoxide dismutase, catalase and decreased the, glutathione peroxidase, and glutathione, thereby restoring the antioxidant status of the organs to almost normal levels.
  
  
  CONCLUSIONS
  The results of this study show that two different doses of tannin supplementation had a favorable effect on plasma glucose and lipid profile concentrations. It also had an influence on attenuating oxidative stress in diabetic tats.
authors.affiliation: Department of Pharmacognosy, School of Pharmaceutical Sciences, Vels Institute of Science Technology and Advanced Studies (VISTAS), Vels University, Pallavaram, Chennai, India.
authors.forename: Ravichandiran
authors.initials: R
authors.lastname: Velayutham
authors.forename: Nirmala
authors.initials: N
authors.lastname: Sankaradoss
authors.forename: K F H Nazeer
authors.initials: KF
authors.lastname: Ahamed
mesh_terms: D000818:Animals; D002855:Chromatography, Thin Layer; D003921:Diabetes Mellitus, Experimental; D003925:Diabetic Angiopathies / Q000188:drug therapy*; D059305:Diet, High-Fat; D030681:Ficus; D006321:Heart / Q000187:drug effects; D006937:Hypercholesterolemia / Q000188:drug therapy*; D006949:Hyperlipidemias / Q000188:drug therapy; D007668:Kidney / Q000187:drug effects / Q000201:enzymology; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D009206:Myocardium / Q000201:enzymology; D008517:Phytotherapy / Q000379:methods*; D024301:Plant Bark; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin / Q000494:pharmacology; D013634:Tannins / Q000494:pharmacology*
chemical_list: D010936:Plant Extracts; D013634:Tannins; D013311:Streptozocin