title: Design, synthesis and biological evaluation of a novel series of 1,3,4-oxadiazole bearing N-methyl-4-(trifluoromethyl)phenyl pyrazole moiety as cytotoxic agents.
abstract: On account of the reported anticancer activity of pyrazoles and oxadiazoles, we have designed and synthesized a novel combinatorial library of S-substituted-1,3,4-oxadiazole bearing N-methyl-4-(trifluoromethyl)phenyl pyrazole moiety and tested for in-vitro cytotoxic activity by MTT assay. Amongst the tested compounds, the compound 5e was the most promising anticancer agent with IC(50) value of 15.54 μM in MCF-7 cells, compared to Doxorubicin as standard drug. The newly synthesized compounds were characterized by NOE, IR, (1)H NMR, (13)C NMR and LC-MS analysis.
authors.affiliation: Department of Chemistry, Mangalore University, Mangalagangotri 574199, Karnataka, India. pppushpan@rediffmail.com
authors.forename: Pushpan
authors.initials: P
authors.lastname: Puthiyapurayil
authors.forename: Boja
authors.initials: B
authors.lastname: Poojary
authors.forename: Chandrashekhar
authors.initials: C
authors.lastname: Chikkanna
authors.forename: Sunil Kumar
authors.initials: SK
authors.lastname: Buridipad
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D045744:Cell Line, Tumor; D060326:Chemistry Techniques, Synthetic; D015195:Drug Design; D006801:Humans; D020128:Inhibitory Concentration 50; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D011720:Pyrazoles / Q000737:chemistry*; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents; D010069:Oxadiazoles; D011720:Pyrazoles; C031280:pyrazole