title: Reduction of cystometric bladder capacity and bladder compliance with time in patients with end-stage renal disease.
abstract: OBJECTIVE
  Reduced bladder capacity and compliance in patients with end-stage renal disease (ESRD) may affect storage and voiding function after kidney transplantation. This study evaluated the bladder capacity, compliance, and lower urinary tract dysfunction in ESRD patients with duration after dialysis and anuria.
  
  
  METHODS
  Adults with ESRD on kidney transplantation waiting list were consecutively enrolled. The survey items included videourodynamic study (VUDS), renal ultrasound, and cystoscopy. The analytical variables assessed included the duration of dialysis, the duration of anuria, cystometric bladder capacity and bladder compliance, voiding phases in VUDS, and cystoscopic findings.
  
  
  RESULTS
  A total of 62 patients with a mean dialysis duration of 58.9 ± 6.3 months were enrolled. The mean cystometric bladder capacity was 178 ± 14 mL and decreased significantly with duration of dialysis (p < 0.001). Anuria was diagnosed in 26 patients, and the mean cystometric bladder capacity decreased significantly with the duration of anuria (p = 0.002). Among the 26 patients with anuria, 16 had a poor bladder compliance. VUDS revealed abnormal storage function in 44 (71.0%) patients and bladder outlet obstruction due to bladder neck dysfunction or urethral narrowing in the voiding phase in 32 (51.6%). Abnormal cystoscopic findings were also noted in 30 (48.4%) patients.
  
  
  CONCLUSIONS
  Cystometric bladder capacity and bladder compliance decreased with longer duration of dialysis, and the presence of anuria contributed to further decreases in cystometric bladder capacity and bladder compliance. More than two-thirds of patients with ESRD had abnormal findings on VUDS.
authors.affiliation: Department of Urology, Buddhist Tzu Chi General Hospital, and Tzu Chi University, Hualien, Taiwan.
authors.forename: Jing-Liang
authors.initials: JL
authors.lastname: Chen
authors.forename: Ming-Che
authors.initials: MC
authors.lastname: Lee
authors.forename: Hann-Chorng
authors.initials: HC
authors.lastname: Kuo
mesh_terms: D000328:Adult; D000368:Aged; D001002:Anuria / Q000503:physiopathology*; D015331:Cohort Studies; D003558:Cystoscopy; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D059411:Lower Urinary Tract Symptoms / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010361:Patients; D012044:Regression Analysis; D006435:Renal Dialysis; D013997:Time Factors; D001745:Urinary Bladder Diseases / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D014563:Urodynamics