title: Malignant migrating partial seizures of infancy controlled by stiripentol and clonazepam.
abstract: The syndrome of malignant migrating partial seizures of infancy (MMPSI) is characterized by early onset of multiple seizure types and overall poor prognosis. Seizures are markedly drug resistant and few reports have suggested the efficacy of some antiepileptic drugs. We report one case of MMPSI in which prolonged seizure control is obtained with an association of clonazepam, levetiracetam and stiripentol, confirming thus the possibility of complete sustained seizure control in this epileptic syndrome. Of more than 60 cases reported to date, ours is the forth in which sustained complete control of seizures was obtained.
authors.affiliation: APHP, Hôpital Robert Debré, Service de Neurologie Pédiatrique, Paris, France.
authors.forename: Dana
authors.initials: D
authors.lastname: Merdariu
authors.forename: Catherine
authors.initials: C
authors.lastname: Delanoë
authors.forename: Nora
authors.initials: N
authors.lastname: Mahfoufi
authors.forename: Vanina
authors.initials: V
authors.lastname: Bellavoine
authors.forename: Stéphane
authors.initials: S
authors.lastname: Auvin
mesh_terms: D000927:Anticonvulsants / Q000627:therapeutic use*; D002998:Clonazepam / Q000627:therapeutic use*; D004148:Dioxolanes / Q000627:therapeutic use*; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000188:drug therapy*; D005260:Female; D019416:Head Movements; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D012640:Seizures / Q000188:drug therapy*; D014839:Vomiting / Q000209:etiology
chemical_list: D000927:Anticonvulsants; D004148:Dioxolanes; D002998:Clonazepam; C021092:stiripentol