title: Contactless conductivity biosensor in microchip containing folic acid as bioreceptor.
abstract: We report a glass/PDMS-based microfluidic biosensor that integrates contactless conductivity transduction and folic acid, a target for tumor biomarker, as a bioreceptor. The device presents relevant advantages such as direct determination--dismiss the use of redox mediators as in faradaic electrochemical techniques--and the absence of the known drawbacks related to the electrode-solution interface. Characterizations of the functionalization processes and chemical sensor are described in this communication.
authors.affiliation: Instituto de Química de São Carlos, Universidade de São Paulo, São Carlos, SP, Brazil.
authors.forename: Renato S
authors.initials: RS
authors.lastname: Lima
authors.forename: Maria H O
authors.initials: MH
authors.lastname: Piazzetta
authors.forename: Angelo L
authors.initials: AL
authors.lastname: Gobbi
authors.forename: Ubirajara P
authors.initials: UP
authors.lastname: Rodrigues-Filho
authors.forename: Pedro A P
authors.initials: PA
authors.lastname: Nascente
authors.forename: Wendell K T
authors.initials: WK
authors.lastname: Coltro
authors.forename: Emanuel
authors.initials: E
authors.lastname: Carrilho
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D015374:Biosensing Techniques; D004129:Dimethylpolysiloxanes / Q000737:chemistry; D004553:Electric Conductivity; D004566:Electrodes; D005492:Folic Acid / Q000737:chemistry*; D005898:Glass; D006801:Humans; D046210:Microfluidic Analytical Techniques; D009369:Neoplasms / Q000175:diagnosis; D010084:Oxidation-Reduction
chemical_list: D014408:Biomarkers, Tumor; D004129:Dimethylpolysiloxanes; C013830:baysilon; D005492:Folic Acid