title: Intraoperative intraperitoneal chemotherapy with cisplatin in epithelial ovarian cancer.
abstract: OBJECTIVE
  To assess retrospectively the feasibility of intraoperative intraperitoneal (IP) chemotherapy with cisplatin in epithelial ovarian cancer.
  
  
  METHODS
  IP chemotherapy during optimal staging surgery was performed in 10 patients who were diagnosed with primary epithelial ovarian cancers between April 2008 and February 2011. Cisplatin (70 mg/m(2) in 1 L normal saline solution) was administered in the abdominal cavity for 24 hours postoperatively and then adjuvant chemotherapy was started 2-4 weeks after surgery. Perioperative toxicity of the combined treatment was evaluated until the initiation of postoperative adjuvant chemotherapy.
  
  
  RESULTS
  A total of 23 adverse events were observed in 9 of 10 patients (grade 1, 7; grade 2, 13; grade 3, 3; grade 4, 0). In descending order of frequency, adverse events affected the gastrointestinal system (n=14), hematologic system (n=6), pulmonary system (n=2), and genito-urinary system (n=1). The adverse events did not affect adjuvant systemic chemotherapy schedules. One patient experienced disease recurrence in the liver 16 months after surgery. The remaining 9 patients have been well controlled by chemotherapy and/or observation during the follow-up period of 4 to 39 months after surgery.
  
  
  CONCLUSIONS
  Intraoperative IP chemotherapy with cisplatin during surgical procedures is considered feasible for the treatment of primary epithelial ovarian cancer. Further studies, including long-term, prospective and comparative trials, are needed to validate the efficacy of this combined therapy.
authors.affiliation: Department of Obstetrics and Gynecology, CHA Gangnam Medical Center, CHA University School of Medicine, Seoul, Korea.
authors.forename: Myung Joo
authors.initials: MJ
authors.lastname: Kim
authors.forename: Yong Wook
authors.initials: YW
authors.lastname: Jung
authors.forename: Seok Ju
authors.initials: SJ
authors.lastname: Seong
authors.forename: Bo Sung
authors.initials: BS
authors.lastname: Yoon
authors.forename: Mi La
authors.initials: ML
authors.lastname: Kim
authors.forename: Won Deok
authors.initials: WD
authors.lastname: Joo
authors.forename: Tae Jong
authors.initials: TJ
authors.lastname: Song