title: [Effects of ulinastatin on coagulation in children after cardiopulmonary bypass].
abstract: OBJECTIVE
  To study the effects of ulinastatin on coagulation in children who underwent open-heart surgery with cardiopulmonary bypass (CPB).
  
  
  METHODS
  Fifty children who underwent open-heart surgery for ventricular septal defect were randomly divided into two groups: ulinastatin treatment and control. Before CPB, ulinastatin (1.0×10(4) U/kg) was added to CPB priming fluid only in the ulinastatin treatment group. Activated partial thromboplasin time (APTT), prothrombin time (PT), thrombin time (TT), fibrinogen and international normalized ratio (INR) were measured both before and at 1 hr, 6 hrs and 24 hrs after CPB.
  
  
  RESULTS
  The PT in the ulinastatin group was more prolonged than in the control group at 1 hr after CPB (18.7 ± 0.7 s vs 15.5 ± 0.5 s) and 6 hrs after CPB (17.5 ± 0.6 s vs 15.0 ± 0.6 s). The APTT in the ulinatatin group was also significantly more prolonged than in the control group at 6 hrs after CPB (38.7 ± 3.1 s vs 35.3 ± 3.1 s) and 24 hrs after CPB (34.2 ± 3.0 s vs 31.1 ± 2.6 s).
  
  
  CONCLUSIONS
  Ulinastatin may prolong PT and APTT after CPB, and thus affects coagulation in children.
authors.affiliation: Department of Cardiothoracic surgery, Hunan Children's Hospital, Changsha, China. hp_911@sohu.com
authors.forename: Peng
authors.initials: P
authors.lastname: Huang
authors.forename: Ping-Bo
authors.initials: PB
authors.lastname: Liu
authors.forename: Jin-Wen
authors.initials: JW
authors.lastname: Luo
authors.forename: Ren-Wei
authors.initials: RW
authors.lastname: Chen
authors.forename: Jing-Hua
authors.initials: JH
authors.lastname: Wang
authors.forename: De-Bin
authors.initials: DB
authors.lastname: Zeng
mesh_terms: D001777:Blood Coagulation / Q000187:drug effects*; D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass; D005260:Female; D006023:Glycoproteins / Q000494:pharmacology*; D006801:Humans; D007223:Infant; D008297:Male; D010314:Partial Thromboplastin Time; D011517:Prothrombin Time; D014361:Trypsin Inhibitors / Q000494:pharmacology*
chemical_list: D006023:Glycoproteins; D014361:Trypsin Inhibitors; C028665:urinastatin