title: Fishing for clathrin-coated pit nucleators.
abstract: The membrane-curvature-inducing protein Fcho was proposed to be part of a ubiquitous nucleation mechanism for clathrin-coated pits. However, studies in developing zebrafish embryos now indicate a role for Fcho as a receptor-specific adaptor in bone morphogenetic protein (BMP) signalling, rather than a global coated-pit nucleator.
authors.affiliation: Centre National de la Recherche Scientifique UPR 3082, Laboratoire d'Enzymologie et de Biochimie Structurales, Gif-sur-Yvette Cedex, France. christien.merrifield@lebs.cnrs-gif.fr
authors.forename: Christien J
authors.initials: CJ
authors.lastname: Merrifield
mesh_terms: D033962:Adaptor Protein Complex 2 / Q000502:physiology*; D019521:Body Patterning; D002966:Clathrin / Q000378:metabolism*; D004705:Endocytosis; D050556:Fatty Acid-Binding Proteins; D006801:Humans; D008565:Membrane Proteins; D011506:Proteins / Q000502:physiology*
chemical_list: D033962:Adaptor Protein Complex 2; D002966:Clathrin; C524557:FCHO1 protein, human; C497031:FCHO2 protein, human; D050556:Fatty Acid-Binding Proteins; D008565:Membrane Proteins; D011506:Proteins