title: ELA-DRA polymorphisms are not associated with Equine Arteritis Virus infection in horses from Argentina.
abstract: Polymorphisms at Major Histocompatibility Complex (MHC) genes have been associated with resistance/susceptibility to infectious diseases in domestic animals. The aim of this investigation was to evaluate whether polymorphisms of the DRA gene the Equine Lymphocyte Antigen is associated with susceptibility to Equine Arteritis Virus (EAV) infection in horses in Argentina. The equine DRA gene was screened for polymorphisms using Pyrosequencing® Technology which allowed the detection of three ELA-DRA exon 2 alleles. Neither allele frequencies nor genotypic differentiation exhibited any statistically significant (P-values=0.788 and 0.745) differences between the EAV-infected and no-infected horses. Fisher's exact test and OR calculations did not show any significant association. As a consequence, no association could be established between the serological condition and ELA-DRA.
authors.affiliation: Instituto de Genética Veterinaria Ing. Fernando N Dulout (IGEVET), CCT La Plata-CONICET, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, La Plata, Argentina.
authors.forename: P B
authors.initials: PB
authors.lastname: Kalemkerian
authors.forename: G E
authors.initials: GE
authors.lastname: Metz
authors.forename: P
authors.initials: P
authors.lastname: Peral-Garcia
authors.forename: M G
authors.initials: MG
authors.lastname: Echeverria
authors.forename: G
authors.initials: G
authors.lastname: Giovambattista
authors.forename: S
authors.initials: S
authors.lastname: Díaz
mesh_terms: D000818:Animals; D001118:Argentina / Q000453:epidemiology; D018174:Arterivirus Infections / Q000453:epidemiology / Q000235:genetics / Q000662:veterinary*; D007240:Equartevirus; D005838:Genotype; D006734:Horse Diseases / Q000453:epidemiology / Q000235:genetics* / Q000821:virology; D006736:Horses; D008285:Major Histocompatibility Complex / Q000235:genetics*; D011110:Polymorphism, Genetic