title: Chick development and high dose of bendiocarb.
abstract: Developmental data of carbamate pesticides are scarce although they generally possess low toxicity for vertebrates. The aim of the study was to investigate the toxicity of bendiocarb to liver and central nervous system of chick embryos. Bendiocarb (1600 μg/egg) was administered to the embryo through membrana papyracea on embryonic day 3 and 10. In the liver and central nervous system we observed no macroscopic or microscopic changes. These organs were also investigated for caspase activity in regard to application of bendiocarb and no differences in the caspase immunopositivity were observed in comparison with the control. The embryolethality after bendiocarb respective dose was high (94 %) on the embryonic day 3, though following results indicated no toxicity to investigated organs and no increase in the number of apoptotic cells in survived chick embryos on both the early (day 3 of incubation) and the later (day 10 of incubation) developmental stage.
authors.affiliation: Institute of Anatomy, University of Veterinary Medicine and Pharmacy, Kosice, Slovak Republic. petrovova@uvlf.sk
authors.forename: Eva
authors.initials: E
authors.lastname: Petrovova
authors.forename: David
authors.initials: D
authors.lastname: Sedmera
authors.forename: Lenka
authors.initials: L
authors.lastname: Luptakova
authors.forename: David
authors.initials: D
authors.lastname: Mazensky
authors.forename: Jan
authors.initials: J
authors.lastname: Danko
mesh_terms: D000818:Animals; D020169:Caspases / Q000378:metabolism; D002642:Chick Embryo; D004305:Dose-Response Relationship, Drug; D010575:Pesticides / Q000633:toxicity*; D048448:Phenylcarbamates / Q000008:administration & dosage / Q000633:toxicity*
chemical_list: D010575:Pesticides; D048448:Phenylcarbamates; D020169:Caspases; C007725:bendiocarb