title: [Treatment of preterm delivery--therapeutic algorithm].
abstract: In the recent years the rate of preterm deliveries has not been brought down despite of the new therapeutic management and medications. The aim of this scientific report is to share our algorithm of preterm delivery prevention.
  
  
  METHODS
  Our trial consisted of 23 patients between 26 and 36 weeks of gestation diagnosed with preterm delivery, for a one year period - May 2010 to May 2011. The following therapeutic algorithm was applied: magnesium preparations, B2-mymetics, if no improvement was seen in 24 hour period we continued with Utrogestan, Calcium channel blockers, Indomethacin. Progesterone, who hasn't so far been administered in this gestational age, followed this algorithm: loading dose of three tablets, followed by therapeutic dose of 1 to 2 tablets 3 times a day, and a maintenance dose of 1 tablet 3 times a day. Pregnant wemen under 35 completed gestational weeks were also administered steroid i.m. for prevention of neonatal RDS, followed by Ambroxol per orally.
  
  
  RESULTS
  Our new algorithm prolonged pregnancy for more than 14 days in 82.6% of the cases. Delivery. was postponed with 7 days in 17.4% of the cases, with up to 14 days in 30.4%, with up to 21 days in 26.1% and with more than 21 days in 26.1% of the cases.
  
  
  CONCLUSIONS
  Including progesterone in our common therapeutic scheme we were able to prolong pregnancy significantly.
authors.forename: B
authors.initials: B
authors.lastname: Marinov
authors.forename: A
authors.initials: A
authors.lastname: Andreeva
authors.forename: M
authors.initials: M
authors.lastname: Cankova
mesh_terms: D000551:Ambroxol / Q000627:therapeutic use; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D005100:Expectorants / Q000627:therapeutic use; D005260:Female; D005865:Gestational Age; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use; D007231:Infant, Newborn; D008274:Magnesium / Q000627:therapeutic use; D007752:Obstetric Labor, Premature / Q000188:drug therapy* / Q000517:prevention & control; D011247:Pregnancy; D047928:Premature Birth; D011374:Progesterone / Q000627:therapeutic use; D011372:Progestins / Q000627:therapeutic use
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002121:Calcium Channel Blockers; D005100:Expectorants; D011372:Progestins; D000551:Ambroxol; D011374:Progesterone; D008274:Magnesium; D007213:Indomethacin