title: Mild and ligand-free Pd(II)-catalyzed conjugate additions to hindered γ-substituted cyclohexenones.
abstract: Ligand-free cationic Pd(II) catalyst with NaNO3 as an additive is a highly active catalytic system for conjugate additions to sterically hindered γ-substituted cyclohexenones. More challenging γγ- and βγ-substrates also react well to produce products with quaternary centers in good dr. The conjugate additions occur in a diastereoselective fashion under mild, practical and air-stable conditions, using readily available commercial reagents.
authors.affiliation: School of Engineering and Physical Sciences, Heriot-Watt University , Edinburgh EH14 4AS, Scotland, United Kingdom.
authors.forename: James A
authors.initials: JA
authors.lastname: Jordan-Hore
authors.forename: James N
authors.initials: JN
authors.lastname: Sanderson
authors.forename: Ai-Lan
authors.initials: AL
authors.lastname: Lee