title: [The role of innate immunity in obesity].
abstract: Obesity in Mexico is alarmingly increasing in prevalence in adults and children, and it is a risk factor for the development of insulin resistance, as well as, of other metabolic alterations. The discovery of the expression of the Toll-like receptors (TLRs) in adipocytes, suggests an important role in innate immunity. In different models of obesity, there has been observed an increase of TLRs expression in the fat tissue, therefore TLRs could be involved in systemic inflammation in this disease, and in the development of insulin resistance. TLR activation is mediated by fatty acids and their expression is regulated by leptin, adiponectin and PPARs. Knowledge of the role of TLRs in inflammation and adipocyte differentiation and their regulation, then it is important to try to develop new therapeutic anti-inflammatory targets that contribute in the treatment of obesity.
authors.affiliation: Programa de Doctorado en Biología Experimental, Universidad Autónoma Metropolitama, México, DF, México.
authors.forename: Angeles
authors.initials: A
authors.lastname: Fortis
authors.forename: Rebeca
authors.initials: R
authors.lastname: García-Macedo
authors.forename: Carmen
authors.initials: C
authors.lastname: Maldonado-Bernal
authors.forename: Francisco
authors.initials: F
authors.lastname: Alarcón-Aguilar
authors.forename: Miguel
authors.initials: M
authors.lastname: Cruz
mesh_terms: D005227:Fatty Acids / Q000502:physiology; D006801:Humans; D007113:Immunity, Innate; D009765:Obesity / Q000276:immunology*; D051193:Toll-Like Receptors / Q000276:immunology
chemical_list: D005227:Fatty Acids; D051193:Toll-Like Receptors