title: Molecular recognition of carbohydrates: evaluation of the binding properties of pyrazole-based receptors and their comparison with imidazole- and indole-based systems.
abstract: The aim of the study was to evaluate the potential of pyrazole-based receptors in the complexation of carbohydrates. Representatives of a new series of acyclic pyrazole-based receptors were prepared and their binding properties toward selected mono- and disaccharides evaluated. The results of the binding studies were compared with those obtained for acyclic imidazole- and indole-based receptors. The first binding studies revealed di- vs monosaccharide binding preferences of the new receptors and showed that pyrazole units are useful building blocks for the construction of receptors with interesting binding preferences.
authors.affiliation: Institut für Organische Chemie, Technische Universität Braunschweig, 38106 Braunschweig, Germany.
authors.forename: Claudia
authors.initials: C
authors.lastname: Sonnenberg
authors.forename: André
authors.initials: A
authors.lastname: Hartmann
authors.forename: Monika
authors.initials: M
authors.lastname: Mazik
mesh_terms: D002241:Carbohydrates / Q000737:chemistry*; D007093:Imidazoles / Q000737:chemistry; D007211:Indoles / Q000737:chemistry; D011720:Pyrazoles / Q000737:chemistry*
chemical_list: D002241:Carbohydrates; D007093:Imidazoles; D007211:Indoles; D011720:Pyrazoles