title: Sequence-specific synthesis of macromolecules using DNA-templated chemistry.
abstract: Using a strand exchange mechanism we have prepared, by DNA templated chemistry, two 10-mers with defined and tunable monomer sequences. An optimized reaction protocol achieves 85% coupling yield per step, demonstrating that DNA-templated chemistry is a powerful tool for the synthesis of macromolecules with full sequence control.
authors.affiliation: Department of Chemistry, University of Warwick, Coventry, CV4 7AL, UK.
authors.forename: Phillip J
authors.initials: PJ
authors.lastname: Milnes
authors.forename: Mireya L
authors.initials: ML
authors.lastname: McKee
authors.forename: Jonathan
authors.initials: J
authors.lastname: Bath
authors.forename: Lijiang
authors.initials: L
authors.lastname: Song
authors.forename: Eugen
authors.initials: E
authors.lastname: Stulz
authors.forename: Andrew J
authors.initials: AJ
authors.lastname: Turberfield
authors.forename: Rachel K
authors.initials: RK
authors.lastname: O'Reilly
mesh_terms: D001483:Base Sequence; D060326:Chemistry Techniques, Synthetic / Q000379:methods*; D004247:DNA / Q000138:chemical synthesis / Q000737:chemistry*; D046911:Macromolecular Substances / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D046911:Macromolecular Substances; D004247:DNA