title: DNA characterization by transverse electrical current in a nanochannel.
abstract: We review an approach for the characterization of single-stranded DNA based on the statistical identification of single bases via transverse electronic transport while DNA translocates in a nanopore or nanochannel. We describe the theoretical methods used to demonstrate this method for experimentally realizable systems and discuss the different physical processes involved. Recent experimental reports have shown the validity of this approach, although further work is necessary to make this a practical fast sequencing tool.
authors.affiliation: Department of Physics, University of California, San Diego, CA, USA. diventra@physics.ucsd.edu
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Di Ventra
authors.forename: Matt
authors.initials: M
authors.lastname: Krems
authors.forename: James
authors.initials: J
authors.lastname: Wilson
authors.forename: Yuriy V
authors.initials: YV
authors.lastname: Pershin
mesh_terms: D000465:Algorithms; D004277:DNA, Single-Stranded / Q000737:chemistry*; D004553:Electric Conductivity; D056004:Molecular Dynamics Simulation; D058608:Nanopores; D011789:Quantum Theory; D017422:Sequence Analysis, DNA / Q000379:methods; D059629:Signal-To-Noise Ratio; D017655:Silicon Compounds / Q000737:chemistry
chemical_list: D004277:DNA, Single-Stranded; D017655:Silicon Compounds; C032734:silicon nitride