title: Genetic variability at the TREX1 locus is not associated with natural resistance to HIV-1 infection.
abstract: Three prime repair exonuclease 1 (TREX1) degrades excess HIV-1 DNA, thereby preventing recognition by innate immunity receptors and type I interferon responses. Analyses performed in two HIV-exposed seronegative (HESN) cohorts did not show any differences in TREX1 sequence, single nucleotide polymorphisms frequency, or expression in HESN compared to controls, suggesting that, despite its central role in the HIV-1 infection process, genetic diversity at TREX1 is not a major determinant of susceptibility to infection in humans.
authors.affiliation: Scientific Institute IRCCS E.MEDEA, Bosisio Parini, Lecco, Italy.
authors.forename: Manuela
authors.initials: M
authors.lastname: Sironi
authors.forename: Mara
authors.initials: M
authors.lastname: Biasin
authors.forename: Diego
authors.initials: D
authors.lastname: Forni
authors.forename: Rachele
authors.initials: R
authors.lastname: Cagliani
authors.forename: Mariacristina
authors.initials: M
authors.lastname: De Luca
authors.forename: Irma
authors.initials: I
authors.lastname: Saulle
authors.forename: Sergio Lo
authors.initials: SL
authors.lastname: Caputo
authors.forename: Francesco
authors.initials: F
authors.lastname: Mazzotta
authors.forename: Juan
authors.initials: J
authors.lastname: Macias
authors.forename: Juan A
authors.initials: JA
authors.lastname: Pineda
authors.forename: Antonio
authors.initials: A
authors.lastname: Caruz
authors.forename: Mario
authors.initials: M
authors.lastname: Clerici
mesh_terms: D004198:Disease Susceptibility / Q000276:immunology; D005090:Exodeoxyribonucleases / Q000235:genetics* / Q000378:metabolism*; D005260:Female; D014644:Genetic Variation; D015658:HIV Infections / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007113:Immunity, Innate / Q000235:genetics* / Q000276:immunology; D008297:Male; D010750:Phosphoproteins / Q000235:genetics* / Q000378:metabolism*; D020641:Polymorphism, Single Nucleotide; D014779:Virus Replication
chemical_list: D010750:Phosphoproteins; D005090:Exodeoxyribonucleases; C429526:three prime repair exonuclease 1