title: Expression of podoplanin and ABCG2 in oral erythroplakia correlate with oral cancer development.
abstract: Oral erythroplakia (OE) is a notoriously aggressive oral premalignant lesion with a high tendency to oral cancer development, but it's biological behavior is largely unknown. The objective of the current study was to determine podoplanin and ABCG2 immunoexpression in OE and both correlation to malignant transformation of OE. In a retrospective follow-up study, the expression patterns of podoplanin and ABCG2 were determined using immunohistochemistry in samples from 34 patients with OE, including patients with untransformed lesions (n=17) and patients with malignant transformed lesions (n=17). Podoplanin and ABCG2 expression was observed in 15 (44.1%) and 21 (61.8%) of 34 patients, respectively. Multivariate analysis revealed that podoplanin and ABCG2 expression was associated with 6.31-fold (95% confidence interval [CI], 1.02-38.92; P=0.047) and 14.39-fold (95% CI, 2.02-102.29; P=0.008) increased the risk of transformation, respectively. Point prevalence analysis revealed that 90.9% (95% CI, 70.7-100) of the patient with both podoplanin and ABCG2 positivity developed oral cancer. Collectively, our data indicated that the expression patterns of podoplanin and ABCG2 in OE were associated with oral cancer development, suggesting that podoplanin and ABCG2 may be valuable predictors for evaluating oral cancer risk.
authors.affiliation: Department of Preventive Dentistry, Shanghai Municipal Hospital for Oral Health, Shanghai, China.
authors.forename: Jin-Qiu
authors.initials: JQ
authors.lastname: Feng
authors.forename: Jun-Guo
authors.initials: JG
authors.lastname: Mi
authors.forename: Lan
authors.initials: L
authors.lastname: Wu
authors.forename: Li-Wei
authors.initials: LW
authors.lastname: Ma
authors.forename: Lin-Jun
authors.initials: LJ
authors.lastname: Shi
authors.forename: Xi
authors.initials: X
authors.lastname: Yang
authors.forename: Wei
authors.initials: W
authors.lastname: Liu
authors.forename: Chen-Ping
authors.initials: CP
authors.lastname: Zhang
authors.forename: Zeng-Tong
authors.initials: ZT
authors.lastname: Zhou
mesh_terms: D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism*; D008875:Middle Aged; D009059:Mouth Diseases / Q000150:complications / Q000378:metabolism*; D009062:Mouth Neoplasms / Q000150:complications / Q000378:metabolism*; D015999:Multivariate Analysis; D009363:Neoplasm Proteins / Q000378:metabolism*; D012189:Retrospective Studies; D000098853:Podoplanin
chemical_list: D000070997:ATP Binding Cassette Transporter, Subfamily G, Member 2; D018528:ATP-Binding Cassette Transporters; D008562:Membrane Glycoproteins; D009363:Neoplasm Proteins; C116614:ABCG2 protein, human; C117468:PDPN protein, human; D000098853:Podoplanin