title: A uniform sub-50 nm-sized magnetic/upconversion fluorescent bimodal imaging agent capable of generating singlet oxygen by using a 980 nm laser.
abstract: Upconverting nanoparticles (UCNPs) with fascinating properties hold great potential as nanotransducers for solving the problems that traditional photodynamic therapy (PDT) has been facing. In this report, by using well-selected bifunctional gadolinium (Gd)-ion-doped UCNPs and water-soluble methylene blue (MB) combined with the water-in-oil reverse microemulsion technique, we have succeeded in developing a new kind of UCNP/MB-based PDT drug, NaYF(4):Er/Yb/Gd@SiO(2)(MB), with a particle diameter less than 50 nm. Great efforts have been made to investigate the drug-formation mechanism and provide detailed physical and photochemical characterizations and the potential structure optimization of the as-designed PDT drug. We envision that such a PDT drug will become a potential theranostic nanomedicine for future near-infrared laser-triggered photodynamic therapy and simultaneous magnetic/optical bimodal imaging.
authors.affiliation: Group of Mesoporous and Low-Dimensional Nano-Materials, State Key Laboratory of High-Performance, Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai, Dingxi Road 1295 Shanghai, PR China.
authors.forename: Feng
authors.initials: F
authors.lastname: Chen
authors.forename: Shengjian
authors.initials: S
authors.lastname: Zhang
authors.forename: Wenbo
authors.initials: W
authors.lastname: Bu
authors.forename: Yu
authors.initials: Y
authors.lastname: Chen
authors.forename: Qingfeng
authors.initials: Q
authors.lastname: Xiao
authors.forename: Jianan
authors.initials: J
authors.lastname: Liu
authors.forename: Huaiyong
authors.initials: H
authors.lastname: Xing
authors.forename: Liangping
authors.initials: L
authors.lastname: Zhou
authors.forename: Weijun
authors.initials: W
authors.lastname: Peng
authors.forename: Jianlin
authors.initials: J
authors.lastname: Shi
mesh_terms: D007834:Lasers; D008280:Magnetics; D008751:Methylene Blue / Q000737:chemistry; D053758:Nanoparticles / Q000737:chemistry*; D010778:Photochemotherapy / Q000379:methods; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000737:chemistry; D026082:Singlet Oxygen / Q000737:chemistry*
chemical_list: D017319:Photosensitizing Agents; D026082:Singlet Oxygen; D008751:Methylene Blue