title: Isolation, identification, semi-synthesis of aziditaxel derivatives and their biological evaluation.
abstract: Two new taxoids (5 and 6) were obtained by isolating impurities in aziditaxel, and their structures were characterized based on data analysis of (1)H NMR, (13)C NMR, HPLC-MS, and through comparison with literature. In order to test their cytotoxicities against human nonsmall lung cancer cell lines (A549), sufficient amounts of compounds 5 and 6 were obtained by semi-synthesis and both of them showed equipotent cytotoxiesty compared with taxol, docetaxel, and aziditaxel.
authors.affiliation: State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China.
authors.forename: Shu-En
authors.initials: SE
authors.lastname: Zhang
authors.forename: Jia-Yi
authors.initials: JY
authors.lastname: Tao
authors.forename: Ying
authors.initials: Y
authors.lastname: Zhao
authors.forename: Shao-Rong
authors.initials: SR
authors.lastname: Wang
authors.forename: Di
authors.initials: D
authors.lastname: Zhou
authors.forename: Wei-Shuo
authors.initials: WS
authors.lastname: Fang
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002289:Carcinoma, Non-Small-Cell Lung; D000077143:Docetaxel; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008175:Lung Neoplasms; D015394:Molecular Structure; D019906:Nuclear Magnetic Resonance, Biomolecular; D017239:Paclitaxel / Q000494:pharmacology; D043823:Taxoids / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D043823:Taxoids; D000077143:Docetaxel; D017239:Paclitaxel