title: Programmed anti-inflammatory macrophages protect against AKI and promote repair through trophic actions.
abstract: Because pharmacological interventions for the treatment of acute kidney injury (AKI) have remained ineffective, cell-based therapies have been developed. Marrow stromal cells have been found to be safe and potentially effective in study subjects. Jung et al. demonstrate that macrophages made to overexpress anti-inflammatory interleukin-10 protect rats with AKI through iron-mediated upregulation of lipocalin-2 and its receptors, eliciting both anti-inflammatory and proliferative responses. These data further advance our understanding of cell-based therapies for AKI.
authors.affiliation: Division of Nephrology, University of Utah and George E. Wahlen Veterans Affairs Medical Centers, Salt Lake City, Utah, USA. Electronic address: christof.westenfelder@hsc.utah.edu.
authors.forename: Christof
authors.initials: C
authors.lastname: Westenfelder
mesh_terms: D058186:Acute Kidney Injury / Q000517:prevention & control*; D019264:Adoptive Transfer; D000818:Animals; D006801:Humans; D016753:Interleukin-10 / Q000096:biosynthesis*; D007511:Ischemia / Q000628:therapy*; D007668:Kidney / Q000378:metabolism*; D000071068:Lipocalin-2; D054834:Lipocalins / Q000378:metabolism*; D008264:Macrophages / Q000637:transplantation*; D008297:Male; D015427:Reperfusion Injury / Q000517:prevention & control*
chemical_list: C097278:Lcn2 protein, rat; D000071068:Lipocalin-2; D054834:Lipocalins; D016753:Interleukin-10