title: Cognitive and sensorimotor tasks for assessing functional impairments in mouse models of Alzheimer's disease and related disorders.
abstract: In the last couple of decades, substantial progress has been made in the development of transgenic mouse models developing amyloid-β deposits and/or neurofibrillary tangles. These mouse models of Alzheimer's disease and related disorders provide an excellent tool for investigating etiology, pathogenic mechanisms, and potential treatments. An essential component of their characterization is a detailed behavioral assessment, which clarifies the functional consequences of these pathologies. We have selected and refined a series of cognitive and sensorimotor tasks that are ideal for studying these models and the efficacy of various treatments.
authors.affiliation: Department of Physiology, New York University School of Medicine, New York, NY, USA. Allal.Boutajangout@nyumc.org
authors.forename: Allal
authors.initials: A
authors.lastname: Boutajangout
authors.forename: Yong Sheng
authors.initials: YS
authors.lastname: Li
authors.forename: David
authors.initials: D
authors.lastname: Quartermain
authors.forename: Einar M
authors.initials: EM
authors.lastname: Sigurdsson
mesh_terms: D000544:Alzheimer Disease / Q000503:physiopathology*; D000818:Animals; D003071:Cognition; D004195:Disease Models, Animal; D018782:Maze Learning / Q000502:physiology; D051379:Mice; D009043:Motor Activity / Q000502:physiology*; D045442:Rotarod Performance Test