title: Extravascular injection of sclerotic agents does not affect vessels in the rat: experimental implications for percutaneous sclerotherapy of arteriovenous malformations.
abstract: OBJECTIVE
  Sclerotherapy is useful for the treatment of arteriovenous vascular malformations. However, intravascular administration of sclerotic agents into small arteriovenous niduses is often difficult. Extravascular administration of sclerotic agents causes reduction of vascular flow on Doppler echo during clinical sclerotherapy. Therefore, we aimed to investigate whether the extravascular injection of sclerotic agents affects tiny vessels.
  
  
  METHODS
  Animal study.
  
  
  METHODS
  The effect of extravascular injection of sclerotic agents on vessels was investigated using rat femoral and superficial inferior epigastric vessels.
  
  
  METHODS
  After surgical exposure of vessels, absolute ethanol, 5% ethanolamine oleate and 3% polidocanol were injected into perivascular surrounding tissues, and their effect on vessels was evaluated after 14 days using histology and coloured silicone rubber injection.
  
  
  RESULTS
  The integrity of the vascular lumen, endothelial cells and vascular patency were not affected by injection of sclerotic agents.
  
  
  CONCLUSIONS
  Attenuation of vascular flow of an arteriovenous shunt after extravascular injection of sclerotic agents is transient and/or trivial and does not cause disruption of vessels. Therefore, sclerotic agents should be delivered to obtain sufficient destruction of arteriovenous malformation lesions and blood flow.
authors.affiliation: Department of Plastic Surgery, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka-shi, Tokyo 181-8611, Japan.
authors.forename: D
authors.initials: D
authors.lastname: Sato
authors.forename: M
authors.initials: M
authors.lastname: Kurita
authors.forename: M
authors.initials: M
authors.lastname: Ozaki
authors.forename: N
authors.initials: N
authors.lastname: Kaji
authors.forename: A
authors.initials: A
authors.lastname: Takushima
authors.forename: K
authors.initials: K
authors.lastname: Harii
mesh_terms: D000818:Animals; D001165:Arteriovenous Malformations / Q000628:therapy*; D004195:Disease Models, Animal; D004730:Endothelium, Vascular / Q000187:drug effects / Q000473:pathology; D019074:Epigastric Arteries / Q000002:abnormalities / Q000187:drug effects*; D000431:Ethanol / Q000008:administration & dosage; D005263:Femoral Artery / Q000002:abnormalities / Q000187:drug effects*; D005268:Femoral Vein / Q000002:abnormalities / Q000187:drug effects*; D005500:Follow-Up Studies; D007267:Injections; D009829:Oleic Acids / Q000008:administration & dosage; D000077423:Polidocanol; D011092:Polyethylene Glycols / Q000008:administration & dosage; D051381:Rats; D017208:Rats, Wistar; D012597:Sclerosing Solutions / Q000008:administration & dosage*; D015911:Sclerotherapy / Q000379:methods*; D012997:Solvents / Q000008:administration & dosage; D014014:Tissue Adhesives; D016896:Treatment Outcome
chemical_list: D009829:Oleic Acids; D012597:Sclerosing Solutions; D012997:Solvents; D014014:Tissue Adhesives; D000077423:Polidocanol; D000431:Ethanol; D011092:Polyethylene Glycols; C033343:ethanolamine oleate