title: Comparative spatiotemporal analysis of the intrathecal immune response in natural listeric rhombencephalitis of cattle and small ruminants.
abstract: This study examined the spatiotemporal immune response in listeric rhombencephalitis of ruminants in situ. Our data support the view that astrocytes facilitate the containment of infectious lesions. Results on the natural disease recapitulate observations in experimental rodent models and suggest that the mounted adaptive lymphocytic response of ruminants is effective in eliminating Listeria monocytogenes (LM). However, our data indicate earlier participation of the adaptive immune response, a stronger B lymphocyte contribution and a more protracted macrophage infiltration in the natural disease than it has been deduced from experimental models. Therefore, such models should be complemented by studies in natural host systems. Various macrophage and microglia subsets are involved in listeric rhombencephalitis and their differential contribution may account for species differences in clinical course and outcome of infection as might species differences in the B-cell response. Future functional ex vivo and in vitro studies are necessary to further investigate the findings obtained in the present study.
authors.affiliation: Institute of Animal Pathology, Vetsuisse Faculty, University of Bern, Switzerland.
authors.forename: Stefano
authors.initials: S
authors.lastname: Di Palma
authors.forename: Barbara
authors.initials: B
authors.lastname: Brunetti
authors.forename: Marcus G
authors.initials: MG
authors.lastname: Doherr
authors.forename: Ursula
authors.initials: U
authors.lastname: Forster
authors.forename: Monika
authors.initials: M
authors.lastname: Hilbe
authors.forename: Andreas
authors.initials: A
authors.lastname: Zurbriggen
authors.forename: Marc
authors.initials: M
authors.lastname: Vandevelde
authors.forename: Anna
authors.initials: A
authors.lastname: Oevermann
mesh_terms: D056704:Adaptive Immunity; D000818:Animals; D015703:Antigens, CD / Q000276:immunology; D015214:Antigens, Differentiation, Myelomonocytic / Q000276:immunology; D058491:Bacterial Load; D001921:Brain / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000382:microbiology; D002417:Cattle / Q000276:immunology* / Q000382:microbiology; D002418:Cattle Diseases / Q000276:immunology / Q000382:microbiology; D004660:Encephalitis / Q000276:immunology / Q000382:microbiology / Q000662:veterinary*; D015511:Goat Diseases / Q000276:immunology / Q000382:microbiology; D006041:Goats / Q000276:immunology* / Q000382:microbiology; D007150:Immunohistochemistry; D008089:Listeria monocytogenes / Q000276:immunology* / Q000472:pathogenicity; D008088:Listeriosis / Q000276:immunology / Q000382:microbiology / Q000662:veterinary*; D017628:Microglia / Q000276:immunology / Q000382:microbiology; D012756:Sheep / Q000276:immunology* / Q000382:microbiology; D012757:Sheep Diseases / Q000276:immunology / Q000382:microbiology; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; C067980:CD68 antigen, human; D000097382:CD68 Molecule