title: Type I IFN-mediated regulation of IL-1 production in inflammatory disorders.
abstract: Although contributing to inflammatory responses and to the development of certain autoimmune pathologies, type I interferons (IFNs) are used for the treatment of viral, malignant, and even inflammatory diseases. Interleukin-1 (IL-1) is a strongly pyrogenic cytokine and its importance in the development of several inflammatory diseases is clearly established. While the therapeutic use of IL-1 blocking agents is particularly successful in the treatment of innate-driven inflammatory disorders, IFN treatment has mostly been appreciated in the management of multiple sclerosis. Interestingly, type I IFNs exert multifaceted immunomodulatory effects, including the reduction of IL-1 production, an outcome that could contribute to its efficacy in the treatment of inflammatory diseases. In this review, we summarize the current knowledge on IL-1 and IFN effects in different inflammatory disorders, the influence of IFNs on IL-1 production, and discuss possible therapeutic avenues based on these observations.
authors.affiliation: Department of Biochemistry, University of Lausanne, Epalinges, Switzerland. Kristina.Ludigs@unil.ch
authors.forename: Kristina
authors.initials: K
authors.lastname: Ludigs
authors.forename: Valeriy
authors.initials: V
authors.lastname: Parfenov
authors.forename: Renaud A
authors.initials: RA
authors.lastname: Du Pasquier
authors.forename: Greta
authors.initials: G
authors.lastname: Guarda
mesh_terms: D000818:Animals; D006801:Humans; D007249:Inflammation / Q000188:drug therapy* / Q000378:metabolism*; D007370:Interferon Type I / Q000627:therapeutic use*; D007375:Interleukin-1 / Q000378:metabolism*
chemical_list: D007370:Interferon Type I; D007375:Interleukin-1