title: Epilepsy surgery can help many more adult patients with intractable seizures.
abstract: OBJECTIVE
  To quantify underreferral for epilepsy surgery in The Netherlands, and reveal its causes.
  
  
  METHODS
  Cross-sectional sample of medical files of epilepsy patients from eight general hospitals and two tertiary care epilepsy centers. We selected patients, not seizure free despite 3 or more anti-epileptic drugs. Medical records were judged by an expert panel whether referral should have been done according to published Dutch guidelines. The treating neurologists were confronted with the panel's judgement.
  
  
  RESULTS
  In a sample of 1424 patients, 69 had been referred; another 265 were intractable and not referred; 139 of these 265 patients should have been according to the panel. In 89 of 139 patients, the neurologist gave additional arguments for not referring, mainly the physician's estimate of (low) seizure burden or the patient's psychological condition. In 66 of 89 cases, this could not convince the panel. Attitudes were similar in secondary and tertiary treatment centers. Multivariable data analysis showed independent predictors of incorrectly, versus correctly, not referred patients.
  
  
  CONCLUSIONS
  Substantial underreferral exists in The Netherlands, withholding refractory patients seizure freedom. Adherence to existing guidelines, better prioritizing of surgical work-up, and unprejudiced discussion of surgical treatment with the patient, could lead to 2-2.5 times more referrals.
authors.affiliation: University Medical Center Utrecht, Julius Center for Health Sciences and Primary Care, Utrecht, The Netherlands. s.g.uijl@umcutrecht.nl
authors.forename: Sabine G
authors.initials: SG
authors.lastname: Uijl
authors.forename: Frans S S
authors.initials: FS
authors.lastname: Leijten
authors.forename: Karel G M
authors.initials: KG
authors.lastname: Moons
authors.forename: Ellen P H M
authors.initials: EP
authors.lastname: Veltman
authors.forename: Cyrille H
authors.initials: CH
authors.lastname: Ferrier
authors.forename: Cees A
authors.initials: CA
authors.lastname: van Donselaar
mesh_terms: D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D004827:Epilepsy / Q000601:surgery*; D005260:Female; D019983:Guideline Adherence / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009426:Netherlands; D010820:Physicians; D012017:Referral and Consultation / Q000706:statistics & numerical data*; D012189:Retrospective Studies