title: Design, synthesis, and evaluation of a novel class of 2,3-disubstituted-tetrahydro-β-carboline derivatives.
abstract: Several novel tetrahydro-β-carboline derivatives with amino acid residues at the 2-position and a glucosamine group at the 3-position of the tetrahydro-β-carboline nucleus were synthesized from a readily available starting material, tryptophane, and were evaluated for their anti-inflammatory activity in the present study. Our results showed that all of the derivatives tested exhibited a significant inhibition of xylene-induced inflammation in mice.
authors.affiliation: College of Pharmaceutical Sciences, Capital Medical University, Beijing 100069, PR China.
authors.forename: Li
authors.initials: L
authors.lastname: Zeng
authors.forename: Jianwei
authors.initials: J
authors.lastname: Zhang
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D002243:Carbolines / Q000138:chemical synthesis / Q000737:chemistry* / Q000627:therapeutic use; D015195:Drug Design; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005944:Glucosamine / Q000737:chemistry; D051379:Mice; D014364:Tryptophan / Q000737:chemistry; D014992:Xylenes / Q000633:toxicity
chemical_list: D000893:Anti-Inflammatory Agents; D002243:Carbolines; D014992:Xylenes; D014364:Tryptophan; D005944:Glucosamine