title: Trends in intussusception hospitalizations among US infants before and after implementation of the rotavirus vaccination program, 2000-2009.
abstract: BACKGROUND
  Although US data have not documented an intussusception risk with current rotavirus vaccines, international data indicate a possible low risk, primarily after the first dose.
  
  
  METHODS
  Among infants in 26 US states comprising 75% of the birth cohort, we examined age-specific trends in population-level intussusception hospitalization rates before (2000-2005) and after (2007-2009) rotavirus vaccine introduction.
  
  
  RESULTS
  Compared with 2000-2005 (35.3 per 100,000), the rate was greater in 2007 (39.0 per 100,000; rate ratio [RR], 1.10; 95% confidence interval [CI], 1.04-1.18), similar in 2008 (33.4 per 100,000; RR, 0.95; 95% CI, .89-1.01), and lower in 2009 (32.9 per 100,000; RR, 0.93; 95% CI, .87-.99). Among infants aged 8-11 weeks, compared with 2000-2005 (6.9 per 100,000), a small, significant increase was observed in each of 2007 (11.4 per 100,000; RR, 1.64; 95% CI, 1.08-2.50), 2008 (12.2 per 100,000; RR, 1.76; 95% CI, 1.17-2.65), and 2009 (11.0 per 100,000; RR, 1.59; 95% CI, 1.04-2.44).
  
  
  CONCLUSIONS
  Following rotavirus vaccine introduction, a small increase in intussusception rates was seen among US infants aged 8-11 weeks, to whom most first doses of vaccine are given; no sustained population-level change in overall rates was observed.
authors.affiliation: Epidemic Intelligence Service, Scientific Education and Professional Development Program Office, University of Cape Town, Cape Town. cyen@cdc.gov
authors.forename: Catherine
authors.initials: C
authors.lastname: Yen
authors.forename: Jacqueline E
authors.initials: JE
authors.lastname: Tate
authors.forename: Claudia A
authors.initials: CA
authors.lastname: Steiner
authors.forename: Margaret M
authors.initials: MM
authors.lastname: Cortese
authors.forename: Manish M
authors.initials: MM
authors.lastname: Patel
authors.forename: Umesh D
authors.initials: UD
authors.lastname: Parashar
mesh_terms: D000367:Age Factors; D015331:Cohort Studies; D016001:Confidence Intervals; D006760:Hospitalization / Q000639:trends; D006801:Humans; D007223:Infant; D007443:Intussusception / Q000453:epidemiology* / Q000276:immunology / Q000821:virology; D012401:Rotavirus / Q000276:immunology; D012400:Rotavirus Infections / Q000453:epidemiology* / Q000276:immunology / Q000517:prevention & control; D022243:Rotavirus Vaccines / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology; D014481:United States / Q000453:epidemiology; D014611:Vaccination / Q000379:methods
chemical_list: D022243:Rotavirus Vaccines