title: ATP synthesis and storage.
abstract: Since 1929, when it was discovered that ATP is a substrate for muscle contraction, the knowledge about this purine nucleotide has been greatly expanded. Many aspects of cell metabolism revolve around ATP production and consumption. It is important to understand the concepts of glucose and oxygen consumption in aerobic and anaerobic life and to link bioenergetics with the vast amount of reactions occurring within cells. ATP is universally seen as the energy exchange factor that connects anabolism and catabolism but also fuels processes such as motile contraction, phosphorylations, and active transport. It is also a signalling molecule in the purinergic signalling mechanisms. In this review, we will discuss all the main mechanisms of ATP production linked to ADP phosphorylation as well the regulation of these mechanisms during stress conditions and in connection with calcium signalling events. Recent advances regarding ATP storage and its special significance for purinergic signalling will also be reviewed.
authors.affiliation: Department of Experimental and Diagnostic Medicine, Section of General Pathology, Interdisciplinary Center for the Study of Inflammation (ICSI), Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara, Via Borsari, 46, 44121, Ferrara, Italy.
authors.forename: Massimo
authors.initials: M
authors.lastname: Bonora
authors.forename: Simone
authors.initials: S
authors.lastname: Patergnani
authors.forename: Alessandro
authors.initials: A
authors.lastname: Rimessi
authors.forename: Elena
authors.initials: E
authors.lastname: De Marchi
authors.forename: Jan M
authors.initials: JM
authors.lastname: Suski
authors.forename: Angela
authors.initials: A
authors.lastname: Bononi
authors.forename: Carlotta
authors.initials: C
authors.lastname: Giorgi
authors.forename: Saverio
authors.initials: S
authors.lastname: Marchi
authors.forename: Sonia
authors.initials: S
authors.lastname: Missiroli
authors.forename: Federica
authors.initials: F
authors.lastname: Poletti
authors.forename: Mariusz R
authors.initials: MR
authors.lastname: Wieckowski
authors.forename: Paolo
authors.initials: P
authors.lastname: Pinton
mesh_terms: D000255:Adenosine Triphosphate / Q000032:analysis / Q000096:biosynthesis* / Q000378:metabolism; D002118:Calcium / Q000502:physiology; D020013:Calcium Signaling / Q000502:physiology; D004777:Environment; D006801:Humans; D015398:Signal Transduction / Q000502:physiology
chemical_list: D000255:Adenosine Triphosphate; D002118:Calcium