title: Diagnostic and therapeutic challenges in hepatic epithelioid hemangioendothelioma.
abstract: BACKGROUND
  Epithelioid hemangioendothelioma is a very rare, low-grade vascular tumor known to arise in soft tissues and visceral organs. Clinical diagnosis of hepatic epithelioid hemangioendothelioma remains a challenge, and although it is frequently managed with a liver transplant due to its multifocal nature, recurrence is a common complication.
  
  
  METHODS
  We review recent advances in the diagnosis of hepatic epithelioid hemangioendothelioma, including major genetic breakthroughs, and discuss efforts to reduce post-liver transplant recurrence of hepatic epithelioid hemangioendothelioma.
authors.affiliation: Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232-0275, USA. a.mistry@vanderbilt.edu
authors.forename: Akshitkumar M
authors.initials: AM
authors.lastname: Mistry
authors.forename: D Lee
authors.initials: DL
authors.lastname: Gorden
authors.forename: Jacob F
authors.initials: JF
authors.lastname: Busler
authors.forename: Alice C
authors.initials: AC
authors.lastname: Coogan
authors.forename: Beau S
authors.initials: BS
authors.lastname: Kelly
mesh_terms: D018323:Hemangioendothelioma, Epithelioid / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy*; D006801:Humans; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000235:genetics / Q000628:therapy*; D016031:Liver Transplantation; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control