title: Vascular barrier protective effects of eckol and its derivatives.
abstract: In this Letter, we first investigated the barrier protective effects of eckol and its derivatives against pro-inflammatory responses in human umbilical vein endothelial cells (HUVECs) and in mice. Data showed that eckol (1) and dieckol (2) inhibited lipopolysaccharide (LPS)-mediated barrier disruption and transendothelial migration of leukocytes to human endothelial cells. Eckol (1) also suppressed acetic acid induced-hyperpermeability and carboxymethylcellulose-induced leukocytes migration in vivo. Interestingly, the barrier protective effects of dieckol (2) were better than those of eckol (1) and hydroxyl groups in dieckol (2) positively regulate protective effects.
authors.affiliation: Department of Herbal Medicinal Pharmacology, Daegu Haany University, Gyeongsan, Republic of Korea.
authors.forename: Tae Hoon
authors.initials: TH
authors.lastname: Kim
authors.forename: Taeho
authors.initials: T
authors.lastname: Lee
authors.forename: Sae-Kwang
authors.initials: SK
authors.lastname: Ku
authors.forename: Jong-Sup
authors.initials: JS
authors.lastname: Bae
mesh_terms: D019342:Acetic Acid / Q000633:toxicity; D000818:Animals; D002266:Carboxymethylcellulose Sodium / Q000633:toxicity; D002463:Cell Membrane Permeability / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D004147:Dioxins / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D061307:Human Umbilical Vein Endothelial Cells / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007962:Leukocytes / Q000502:physiology; D008070:Lipopolysaccharides / Q000633:toxicity; D051379:Mice; D020011:Protective Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D004147:Dioxins; D008070:Lipopolysaccharides; D020011:Protective Agents; C060311:eckol; D002266:Carboxymethylcellulose Sodium; D019342:Acetic Acid