title: The influence of bone substitute materials on the bone volume after maxillary sinus augmentation: a microcomputerized tomography study.
abstract: OBJECTIVE
  This study aims to evaluate the effect of adding bone substitute materials (BSM) to particulated autogenous bone (PAB) on the volume fraction (Vf) of newly formed bone after maxillary sinus augmentation.
  
  
  METHODS
  Thirty healthy patients undergoing maxillary sinus augmentation were included. PAB (N = 10), mixtures of PAB and beta-tricalciumphosphate (PAB/β-TCP) (N = 10), as well as PAB and β-TCP and hydroxyapatite (PAB/HA/β-TCP) (N = 10) were randomly used for sinus augmentation. A sample of the graft material was maintained from each patient at time of maxillary sinus augmentation, and Vfs of the PAB and/or BSM in the samples were determined by means of microcomputerized tomography (μ-CT). Five months later, samples of the grafted areas were harvested during implantation using a trephine bur. μ-CT analysis of these samples was performed, and the Vf of bone and BSM were compared with the data obtained 5 months earlier from the original material.
  
  
  RESULTS
  The mean Vf of the bone showed a statistically significant increase (p < 0.05) in all groups after a healing period of 5 months without statistically significant difference between the groups.
  
  
  CONCLUSIONS
  With regard to the increase of bone volume, it is not relevant if PAB is used alone or combined with β-TCP or HA/β-TCP.
  
  
  CONCLUSIONS
  The amount of PAB and associated donor site morbidity may be reduced by adding BSM for maxillary sinus augmentation.
authors.affiliation: School of Dental Medicine, Department of Oral Surgery, Oral Radiology and Oral Medicine, University of Basel, Hebelstrasse 3, 4056 Basel, Switzerland. sebastian.kuehl@unibas.ch
authors.forename: Sebastian
authors.initials: S
authors.lastname: Kühl
authors.forename: Christoph
authors.initials: C
authors.lastname: Brochhausen
authors.forename: Hermann
authors.initials: H
authors.lastname: Götz
authors.forename: Andreas
authors.initials: A
authors.lastname: Filippi
authors.forename: Michael
authors.initials: M
authors.lastname: Payer
authors.forename: Bernd
authors.initials: B
authors.lastname: d'Hoedt
authors.forename: Matthias
authors.initials: M
authors.lastname: Kreisler
mesh_terms: D000328:Adult; D000368:Aged; D064592:Autografts / Q000000981:diagnostic imaging / Q000473:pathology / Q000637:transplantation; D015519:Bone Density / Q000502:physiology*; D018786:Bone Substitutes / Q000627:therapeutic use*; D016025:Bone Transplantation / Q000379:methods; D002130:Calcium Phosphates / Q000627:therapeutic use; D017886:Durapatite / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D021621:Imaging, Three-Dimensional / Q000379:methods; D008297:Male; D008437:Maxilla / Q000000981:diagnostic imaging / Q000473:pathology; D008443:Maxillary Sinus / Q000000981:diagnostic imaging / Q000473:pathology; D008875:Middle Aged; D010012:Osteogenesis / Q000502:physiology; D059546:Sinus Floor Augmentation / Q000379:methods*; D055114:X-Ray Microtomography / Q000379:methods*
chemical_list: D018786:Bone Substitutes; D002130:Calcium Phosphates; C485817:beta-tricalcium phosphate; D017886:Durapatite