title: Recovery of endothelial function after sirolimus-eluting stent implantation: a pilot study.
abstract: Whether endothelial dysfunction after sirolimus-eluting stent (SES) implantation is persistent has not been fully evaluated. Endothelial function was evaluated in 152 lesions that underwent follow-up coronary angiography after SES implantation. Lesions were classified into 2 groups according to the duration between SES implantation and follow-up: ≤12 months (n = 95) and >12 months (n = 57). Changes in coronary diameter in response to 10(-8) mol/L (-2.4% ± 6.3% vs -4.9% ± 3.8%, P < .01) and 10(-7) mol/L acetylcholine (Ach; -4.6% ± 7.6% vs -10.7% ± 9.1%, P < .001) in segment proximal to SES were significantly attenuated in the >12-month group than in the ≤12-month group. There were less changes in coronary diameter in response to 10(-8) mol/L (-2.3% ± 4.6% vs -6.9% ± 5.0%, P < .001) and 10(-7) mol/L Ach (-6.5% ± 11.4% vs -16.8% ± 10.5%, P < .001) in segment distal to SES in the >12-month group. Endothelial dysfunction may diminish long after SES implantation.
authors.affiliation: 1Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba, Japan. hidekita.0306@gmail.com
authors.forename: Hideki
authors.initials: H
authors.lastname: Kitahara
authors.forename: Yoshihide
authors.initials: Y
authors.lastname: Fujimoto
authors.forename: Keishi
authors.initials: K
authors.lastname: Ishikawa
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Aoki
authors.forename: Yo
authors.initials: Y
authors.lastname: Iwata
authors.forename: Tadayuki
authors.initials: T
authors.lastname: Kadohira
authors.forename: Tomoki
authors.initials: T
authors.lastname: Morino
authors.forename: Kenji
authors.initials: K
authors.lastname: Ohkubo
authors.forename: Kazumasa
authors.initials: K
authors.lastname: Sugimoto
authors.forename: Yoshio
authors.initials: Y
authors.lastname: Kobayashi
mesh_terms: D000368:Aged; D017023:Coronary Angiography; D003327:Coronary Disease / Q000503:physiopathology* / Q000628:therapy; D054855:Drug-Eluting Stents; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D020123:Sirolimus / Q000008:administration & dosage
chemical_list: D007166:Immunosuppressive Agents; D020123:Sirolimus