title: Ethinylestradiol and levonorgestrel preparations on the Belgian market: a comparative study.
abstract: Preparations formulated as coated or film-coated tablets, containing levonorgestrel and the combination ethinylestradiol/levonorgestrel, were evaluated in a comparative study. This study comprised in vitro dissolution, assay and content uniformity. The analytical methods were previously validated according to international guidelines. All examined products complied with the postulated requirements.
authors.affiliation: APB, Service de Contrôle des Médicaments, Bruxelles.
authors.forename: V
authors.initials: V
authors.lastname: Vanheusden
authors.forename: K
authors.initials: K
authors.lastname: De Braekeleer
authors.forename: J
authors.initials: J
authors.lastname: Corthout
mesh_terms: D001530:Belgium; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D003280:Contraceptives, Oral, Synthetic / Q000008:administration & dosage* / Q000737:chemistry / Q000592:standards; D004338:Drug Combinations; D004997:Ethinyl Estradiol / Q000008:administration & dosage* / Q000737:chemistry / Q000592:standards; D016912:Levonorgestrel / Q000008:administration & dosage* / Q000737:chemistry / Q000592:standards; D015203:Reproducibility of Results; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D013608:Tablets, Enteric-Coated
chemical_list: D003280:Contraceptives, Oral, Synthetic; D004338:Drug Combinations; D013608:Tablets, Enteric-Coated; C072593:ethinyl estradiol, levonorgestrel drug combination; D004997:Ethinyl Estradiol; D016912:Levonorgestrel