title: Repolarization perturbation and hypomagnesemia after extreme exercise.
abstract: OBJECTIVE
  Strenuous exercise induces significant increases in inflammatory and cardiac biomarkers and transient dysfunction of the left ventricle. It is still unclear whether the electrophysiological correlate of these alterations can also be observed in ECG recordings, which indicate increased vulnerability for arrhythmias.
  
  
  METHODS
  ECG parameters were measured and compared with inflammatory and electrolyte statuses in 198 healthy men (42 ± 9 yr) 1 wk before (baseline) and at 0, 24, and 72 h after participating in a marathon.
  
  
  RESULTS
  HR-corrected QT interval (QTc) duration increased significantly immediately after the race (442.4 ± 23.0 ms) compared with baseline (415.3 ± 22.5 ms, P < 0.001) and returned to baseline values within 72 h (415.8 ± 24.7 ms). Other indices of ventricular repolarization (Sagie-Framingham-corrected QTcF, T(peak)-Tend (T(pe)) duration, T(pe)/QT ratio) showed similar results.Compared with baseline, significant decreases in serum concentrations of magnesium and potassium were shown immediately after the race (median (interquartile range): [Mg(2+)] = 0.85 (0.79-0.92) vs 0.77 (0.70-0.82) mmol · L(-1), P < 0.001; [K+] = 4.27 (4.02-4.58) vs 4.14 (3.81-4.57) mmol · L(-1), P < 0.05). Interleukin 6 values were significantly augmented immediately after the race compared with baseline (interleukin 6 = 2.08 (1.96-2.20) vs 30.56 (19.83-43.63) ng · L, P < 0.001) and returned to baseline values within 72 h.Significant associations were not observed between ECG alterations and inflammatory or electrolyte concentrations (all P > 0.05).
  
  
  CONCLUSIONS
  Cardiac repolarization was significantly altered immediately after a marathon, coincident with hypomagnesemia and hypokalemia. Inflammatory and electrolyte statuses returned to baseline values within 72 h. The current data do not support that ECG alterations after marathon running represent an increased risk for arrhythmic events. However, further investigation is warranted to describe these relationships in more detail.
authors.affiliation: Department of Prevention and Sports Medicine, Klinikum rechts der Isar, Technische Universitaet Muenchen, Munich, Germany. scherr@sport.med.tum.de
authors.forename: Johannes
authors.initials: J
authors.lastname: Scherr
authors.forename: Tibor
authors.initials: T
authors.lastname: Schuster
authors.forename: Axel
authors.initials: A
authors.lastname: Pressler
authors.forename: Astrid
authors.initials: A
authors.lastname: Roeh
authors.forename: Jeff
authors.initials: J
authors.lastname: Christle
authors.forename: Bernd
authors.initials: B
authors.lastname: Wolfarth
authors.forename: Martin
authors.initials: M
authors.lastname: Halle
mesh_terms: D000328:Adult; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood; D004562:Electrocardiography; D004573:Electrolytes / Q000097:blood*; D015444:Exercise / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000097:blood; D015850:Interleukin-6 / Q000097:blood*; D008274:Magnesium / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012420:Running / Q000502:physiology*; D055815:Young Adult
chemical_list: D015415:Biomarkers; D004573:Electrolytes; D015850:Interleukin-6; D008274:Magnesium