title: The potential of iPS cells in synucleinopathy research.
abstract: α-synuclein is a protein involved in the pathogenesis of several so-called synucleinopathies including Parkinson's disease. A variety of models have been so far assessed. Human induced pluripotent stem cells provide a patient- and disease-specific model for in vitro  studies, pharmacotoxicological screens, and hope for future cell-based therapies. Initial experimental procedures include the harvest of patients' material for the reprogramming process, the investigation of the patients genetic background in the cultured cells, and the evaluation of disease-relevant factors/proteins under various cell culture conditions.
authors.affiliation: Institute for Anatomy and Cell Biology, Ulm University, 89081 Ulm, Germany.
authors.forename: Leonhard
authors.initials: L
authors.lastname: Linta
authors.forename: Marianne
authors.initials: M
authors.lastname: Stockmann
authors.forename: Tobias M
authors.initials: TM
authors.lastname: Boeckers
authors.forename: Alexander
authors.initials: A
authors.lastname: Kleger
authors.forename: Stefan
authors.initials: S
authors.lastname: Liebau