title: [Switching of osteoblastogenesis versus adipogenesis].
abstract: To maintain a balance between the differentiation of adipocytes and osteoblasts is one of significant issues related to osteoporosis and metabolic syndrome. Both adipocytes and osteoblasts are derived from mesenchymal stem cells and recent studies have shown that osteoblast or adipocyte differentiation regulators reciprocally control each cell differentiations. In particular, PPAR-gamma plays a pivotal role for adipocyte differentiation and directly controls the differentiation of osteoblast and osteoclast. In this report, I summarize recent researches mainly focusing on the transcriptional co-regulators and extracellular signals regulating the transactivation function of PPAR-gamma.
authors.affiliation: Department of Microbiology and Immunology, Keio University School of Medicine, Japan.
authors.forename: Ichiro
authors.initials: I
authors.lastname: Takada
mesh_terms: D017667:Adipocytes / Q000166:cytology* / Q000378:metabolism; D000818:Animals; D002454:Cell Differentiation / Q000235:genetics / Q000502:physiology*; D006801:Humans; D010006:Osteoblasts / Q000166:cytology* / Q000378:metabolism; D010010:Osteoclasts / Q000166:cytology / Q000378:metabolism; D047495:PPAR gamma / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D047495:PPAR gamma