title: Three new triterpenoids from Panax ginseng exhibit cytotoxicity against human A549 and Hep-3B cell lines.
abstract: Three new triterpenoid derivatives, 3-O-β-D-glucopyranosyl-20(S)-protopanaxtriol (1), 3-formyloxy-20-O-β-D-glucopyranosyl-20(S)-protopanaxtriol (2) and 26-hydroxyl-24(E)-20(S)-protopanaxtriol (3), along with six known ginsenosides, were isolated from leaves of Panax ginseng. Their structures were established on the basis of spectral analysis (IR, 1D and 2D NMR, HRESI-MS). Compounds 1-3 exhibited various degree of cytotoxicity towards human A549 pulmonary carcinoma cells and Hep3B hepatoma cells.
authors.affiliation: Pharmacy Department, The Fourth Affiliated Hospital of China Medical University, No. 4, Chongshan Eastern Road, Yuhong District, Shenyang 110032, China. cmu4h-mhy@126.com
authors.forename: Hai-Ying
authors.initials: HY
authors.lastname: Ma
authors.forename: Hui-Yuan
authors.initials: HY
authors.lastname: Gao
authors.forename: Jian
authors.initials: J
authors.lastname: Huang
authors.forename: Bo-Hang
authors.initials: BH
authors.lastname: Sun
authors.forename: Bo
authors.initials: B
authors.lastname: Yang
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology; D045744:Cell Line, Tumor; D049109:Cell Proliferation / Q000187:drug effects; D036145:Ginsenosides / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D015394:Molecular Structure; D005894:Panax / Q000737:chemistry*; D018515:Plant Leaves / Q000737:chemistry; D014315:Triterpenes / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D036145:Ginsenosides; D014315:Triterpenes