title: Domain shuffling and the increasing complexity of biological networks.
abstract: Domains can spread among proteins in a process called domain shuffling and this has been identified as one of the major mechanisms leading to the formation of new proteins throughout evolution. This process has an impact on the topology of protein-protein interaction networks as it may create new hubs and also increase interconnectivity.
authors.affiliation: Ludwig Institute for Cancer Research, São Paulo branch, São Paulo, Brazil. sandro@sandrodesouza.com.br
authors.forename: Sandro J
authors.initials: SJ
authors.lastname: de Souza
mesh_terms: D000818:Animals; D019143:Evolution, Molecular; D006801:Humans; D007438:Introns; D014176:Protein Biosynthesis; D025941:Protein Interaction Mapping; D060066:Protein Interaction Maps; D011506:Proteins / Q000737:chemistry*; D013045:Species Specificity; D049490:Systems Biology
chemical_list: D011506:Proteins