title: [Pathophysiology of complex regional pain syndrome (CRPS) type 1].
abstract: BACKGROUND
  If the pathophysiology of complex regional pain syndrome (CRPS) type 1 remains controversial, most authors agree on a combination in varying proportions, a sensitization of peripheral nerves.
  
  
  OBJECTIVE
  To describe the state of advances in the physiopathology of complex regional pain syndrome type 1.
  
  
  METHODS
  Bibliographic research and literature review performed by referring to databases (Medline, Science Direct)
  
  
  RESULTS
  The physiopathology of complex regional pain syndrome type 1 remains still poorly understood and controversial. Several arguments demonstrated both peripheral (inflammation, abnormal sympathetic ...) and central (neurological and cognitive) mechanisms.
  
  
  CONCLUSIONS
  A better knowledge of the physiopathology of complex pain syndrome type 1 is necessary in order to adapt efficient curative therapy or to a better prevention of this syndrome.
authors.affiliation: Service de Rhumatologie, EPS La Rabta, Tunis.
authors.forename: Dalila
authors.initials: D
authors.lastname: Mrabet
authors.forename: Chekib
authors.initials: C
authors.lastname: Khemiri
authors.forename: Ines
authors.initials: I
authors.lastname: Ben Mrad
authors.forename: Hela
authors.initials: H
authors.lastname: Mrabet
authors.forename: Hamza
authors.initials: H
authors.lastname: Essaddem
authors.forename: Mrabet
authors.initials: M
authors.lastname: Amel
authors.forename: Hela
authors.initials: H
authors.lastname: Sahli
authors.forename: Slaheddine
authors.initials: S
authors.lastname: Sellami
mesh_terms: D006801:Humans; D012019:Reflex Sympathetic Dystrophy / Q000503:physiopathology*