title: Developmental haemostasis for factor V and factor VIII levels in neonates: a case report of spontaneous cephalhaematoma.
abstract: Combined factor V and VIII deficiency is a rare bleeding disorder. Diagnosis of congenital coagulation factor deficiency in a neonate is challenging due to "immaturity" of the hemostatic system. A 2-day-old baby girl presented with spontaneous cephalhematoma. She was found to have persistent abnormal coagulation tests and finally diagnosed as combined factor V and VIII deficiency. Interestingly, factor V and factor VIII in developmental hemostasis are quite similar with adult levels in newborn, and hence early diagnosis is possible. An investigation to detect underlying hemostatic defects is recommended in newborns with spontaneous cephalhematoma.
authors.affiliation: Department of Hematology, Universiti Sains Malaysia, School of Medical Sciences, Kubang Kerian, Kelantan, Malaysia. wzaidah@kb.usm.my
authors.forename: Wan Zaidah
authors.initials: WZ
authors.lastname: Abdullah
authors.forename: Rusmawati
authors.initials: R
authors.lastname: Ismail
authors.forename: Ariffin
authors.initials: A
authors.lastname: Nasir
authors.forename: Norsarwany
authors.initials: N
authors.lastname: Mohamad
authors.forename: Rosline
authors.initials: R
authors.lastname: Hassan
mesh_terms: D001780:Blood Coagulation Tests; D005166:Factor V Deficiency / Q000150:complications*; D005168:Factor VII Deficiency / Q000150:complications*; D005260:Female; D006407:Hematoma, Epidural, Cranial / Q000209:etiology*; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases