title: [Hormone replacement therapy at women with fertility problems and proofs of hypergonadotropic hypoovarism].
abstract: The premature ovarian failure (POF), is the main precondition for the origin and the progress of the hypergonadotropic hypoovarism in part of the women with infertility. The significant decrease of the ovarian reserve, makes the treatment of these patients very difficult and problematic, still pregnancy is observed at 5-10% of them. Objective of the research: To study the effect of the Hormone Replacement Therapy (HRT) on the values of FSH before and after the treatment of women with POF, as well as its effect on the percentage of effective pregnancy. 47 infertile women with high values of FSH were included in the study and they followed a 2-4 month treatment with Trisequens tabl. The results of the ART were reported after the reduction of the FSH levels to the normal values. At the end of the treatment followed, the values of the FSH of 41 from 47 patients (87,23%), were reduced to normal range and necessary reproductive procedures were performed. Dividing the patients in 5 groups by age, it was found that the results depend to the greatest extend on this factor. In the group of women up to 30, pregnancy occurred in 25%, between 30 and 35 years this percentage decreased to 22,2%; in the group 35-40 years it sharply decreased to 10% and over 40 years the percentage was 0%. The total percentage of conceived patients for the whole last contingent is 13,4%. The patients with POF and high levels of FSH are worth to follow a Hormone Replacement Therapy before undertaking the oocyte donation.
authors.forename: M
authors.initials: M
authors.lastname: Monastirska
authors.forename: K
authors.initials: K
authors.lastname: Tsvetkov
authors.forename: A
authors.initials: A
authors.lastname: Simeonova
authors.forename: R
authors.initials: R
authors.lastname: Murad
authors.forename: E
authors.initials: E
authors.lastname: Zheleva
mesh_terms: D000328:Adult; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D020249:Hormone Replacement Therapy; D006801:Humans; D007006:Hypogonadism / Q000209:etiology; D007247:Infertility, Female / Q000628:therapy; D010053:Ovary / Q000187:drug effects; D011247:Pregnancy; D016649:Primary Ovarian Insufficiency / Q000150:complications / Q000628:therapy*; D055815:Young Adult
chemical_list: D005640:Follicle Stimulating Hormone