title: [Improved prognosis in light chain nephropathy due to multiple myeloma].
abstract: A 64 year-old woman with acute renal failure and cast nephropathy due to excessive production of lambda free light chains received chemotherapy (using bortezomib and dexamethason) and haemodialysis with a high cut off-filter. The concentration of free light chains was markedly reduced after a fortnight. Nine months after admission, the patient's kidney function had improved and dialysis was stopped. Three months later, she got an autologous stem cell transplantation. One year later, estimated glomerular filtration rate was 25 ml/min, and the production of free light chains was under control.
authors.affiliation: Medicinsk Afdeling, Medicinsk Forskning, Regionshospitalet Holstebro, Denmark. jakob_juul@yahoo.dk
authors.forename: Jakob Søgaard
authors.initials: JS
authors.lastname: Juul
authors.forename: Thomas
authors.initials: T
authors.lastname: Larsen
authors.forename: Niels
authors.initials: N
authors.lastname: Marcussen
authors.forename: Erling Bjerregaard
authors.initials: EB
authors.lastname: Pedersen
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology / Q000473:pathology / Q000628:therapy; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001897:Boronic Acids / Q000627:therapeutic use; D000069286:Bortezomib; D003907:Dexamethasone / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000096:biosynthesis; D007146:Immunoglobulin lambda-Chains / Q000096:biosynthesis; D007674:Kidney Diseases / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D010265:Paraproteinemias / Q000209:etiology; D011379:Prognosis; D011719:Pyrazines / Q000627:therapeutic use; D033581:Stem Cell Transplantation
chemical_list: D000970:Antineoplastic Agents; D001897:Boronic Acids; D007147:Immunoglobulin Light Chains; D007146:Immunoglobulin lambda-Chains; D011719:Pyrazines; D000069286:Bortezomib; D003907:Dexamethasone