title: Near-infrared light-triggered, targeted drug delivery to cancer cells by aptamer gated nanovehicles.
abstract: A novel cell-targeting, near-infrared light-responsive drug delivery platform based on mesoporous silica-coated gold nanorods that are surface-functionalized with aptamer DNA is constructed. Aptamer DNA is used as both capping and targeting agent. In vitro studies show the feasibility of using this nanocarrier for targeted and noninvasive remote controlled drug delivery and photothermal therapy.
authors.affiliation: Laboratory of Chemical Biology and State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Changchun, Jilin, China.
authors.forename: Xinjian
authors.initials: X
authors.lastname: Yang
authors.forename: Xia
authors.initials: X
authors.lastname: Liu
authors.forename: Zhen
authors.initials: Z
authors.lastname: Liu
authors.forename: Fang
authors.initials: F
authors.lastname: Pu
authors.forename: Jinsong
authors.initials: J
authors.lastname: Ren
authors.forename: Xiaogang
authors.initials: X
authors.lastname: Qu
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D052157:Aptamers, Nucleotide / Q000737:chemistry / Q000633:toxicity*; D045744:Cell Line, Tumor; D004337:Drug Carriers / Q000737:chemistry*; D016650:Fluorescein-5-isothiocyanate / Q000737:chemistry; D006046:Gold / Q000737:chemistry; D006801:Humans; D007259:Infrared Rays; D051379:Mice; D041681:NIH 3T3 Cells; D043942:Nanotubes / Q000737:chemistry*; D009838:Oligodeoxyribonucleotides / Q000737:chemistry / Q000633:toxicity; D016062:Porosity; D012822:Silicon Dioxide / Q000737:chemistry
chemical_list: C513936:AGRO 100; D052157:Aptamers, Nucleotide; D004337:Drug Carriers; D009838:Oligodeoxyribonucleotides; D006046:Gold; D012822:Silicon Dioxide; D016650:Fluorescein-5-isothiocyanate