title: [Multiple self-healing squamous epithelioma is an inherited self-healing skin cancer condition].
abstract: Multiple self-healing squamous epithelioma - Ferguson-Smith disease (MSSE) is an autosomal dominant inherited disease with multiple, recurrent, histologically malignant tumours that undergo spontaneous regression. The gene for MSSE has recently been identified as the transforming growth factor-beta receptor 1 (TGFBR1). Although rare, MSSE constitutes an important model of tumour-biology research. The discovery of the genetic background for MSSE paves the way for further elucidating the mechanisms involved in this peculiar self-healing cancer syndrome.
authors.affiliation: Hudafdeling I og Allergicentret, Odense Universitetshospital, Denmark.
authors.forename: Sigurd
authors.initials: S
authors.lastname: Broesby-Olsen
authors.forename: Stine Krog
authors.initials: SK
authors.lastname: Frandsen
authors.forename: Mads
authors.initials: M
authors.lastname: Thomassen
authors.forename: Flemming
authors.initials: F
authors.lastname: Brandrup
authors.forename: Anne-Marie
authors.initials: AM
authors.lastname: Gerdes
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007636:Keratoacanthoma / Q000235:genetics / Q000473:pathology; D009154:Mutation; D009365:Neoplasm Regression, Spontaneous / Q000235:genetics*; D009378:Neoplasms, Multiple Primary / Q000235:genetics* / Q000473:pathology; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics / Q000473:pathology; D018125:Receptors, Transforming Growth Factor beta / Q000235:genetics; D012878:Skin Neoplasms / Q000235:genetics* / Q000473:pathology
chemical_list: D018125:Receptors, Transforming Growth Factor beta