title: HIV-1 tropism evolution after short-term maraviroc monotherapy in HIV-1-infected patients.
abstract: We analyzed the evolution of viral tropism after 8 days of maraviroc monotherapy, i.e., we used the maraviroc clinical test (MCT), in 21 patients with and 14 without virological response to the drug (MCT(+) and MCT(-) patients, respectively). No increases in CXCR4 inferred viral loads (X4IVLs) were observed in MCT(+) patients, while X4IVLs increased only in MCT(-) patients, with X4IVLs of >2 log(10) HIV RNA copies/ml. These results shed light on the evolution of viral tropism under a CCR5 antagonist in vivo.
authors.affiliation: Laboratorio de Inmunovirologia, Servicio Enfermedades Infecciosas, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.
authors.forename: Alejandro
authors.initials: A
authors.lastname: Gonzalez-Serna
authors.forename: María Concepción
authors.initials: MC
authors.lastname: Romero-Sánchez
authors.forename: Sara
authors.initials: S
authors.lastname: Ferrando-Martinez
authors.forename: Miguel
authors.initials: M
authors.lastname: Genebat
authors.forename: Francesc
authors.initials: F
authors.lastname: Vidal
authors.forename: Maria Ángeles
authors.initials: MÁ
authors.lastname: Muñoz-Fernández
authors.forename: María Antonia
authors.initials: MA
authors.lastname: Abad
authors.forename: Manuel
authors.initials: M
authors.lastname: Leal
authors.forename: Ezequiel
authors.initials: E
authors.lastname: Ruiz-Mateos
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use*; D065100:CCR5 Receptor Antagonists; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism; D003510:Cyclohexanes / Q000627:therapeutic use*; D015658:HIV Infections / Q000188:drug therapy* / Q000378:metabolism / Q000821:virology*; D006801:Humans; D000077592:Maraviroc; D019718:Receptors, CXCR4 / Q000378:metabolism; D014230:Triazoles / Q000627:therapeutic use*; D019562:Viral Load / Q000187:drug effects
chemical_list: D019380:Anti-HIV Agents; D065100:CCR5 Receptor Antagonists; C527276:CXCR4 protein, human; D003510:Cyclohexanes; D019718:Receptors, CXCR4; D014230:Triazoles; D000077592:Maraviroc