title: Spectroscopic and electrochemical characterization of gold(I) and gold(III) complexes with glyoxaldehyde bis(thiosemicarbazones): cytotoxicity against human tumor cell lines and inhibition of thioredoxin reductase activity.
abstract: Complexes [Au(2)(H(2)Gy3DH)(2)]Cl(2) (1), [Au(H(2)Gy3Me)]Cl(3) (2) and [Au(H(2)Gy3Et)]Cl(3) (3) were obtained with glyoxaldehyde bis(thiosemicarbazone) (H(2)Gy3DH) and its N(3)-methyl (H(2)Gy3Me) and N(3)-ethyl (H(2)Gy3Et) derivatives. The bis(thiosemicarbazones) and their gold(I) and gold(III) complexes exhibited anti-proliferative activity against HL-60, Jurkat (leukemia) and MCF-7 (breast cancer) cells at 10 μmol L(-1). Complex (2) was able to in vitro inhibit thioredoxin reductase (TrxR) activity, which suggests that inhibition of TrxR could be part of its mechanism of action.
authors.affiliation: Departamento de Química, Universidade Federal de Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil.
authors.forename: Josane A
authors.initials: JA
authors.lastname: Lessa
authors.forename: Karina S O
authors.initials: KS
authors.lastname: Ferraz
authors.forename: Juliana C
authors.initials: JC
authors.lastname: Guerra
authors.forename: Luana F
authors.initials: LF
authors.lastname: de Miranda
authors.forename: Carla F D
authors.initials: CF
authors.lastname: Romeiro
authors.forename: Elaine M
authors.initials: EM
authors.lastname: Souza-Fagundes
authors.forename: Paulo Jorge S
authors.initials: PJ
authors.lastname: Barbeira
authors.forename: Heloisa
authors.initials: H
authors.lastname: Beraldo
mesh_terms: D045744:Cell Line, Tumor; D004563:Electrochemistry; D004789:Enzyme Activation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology*; D006046:Gold / Q000737:chemistry*; D018922:HL-60 Cells; D006801:Humans; D013880:Thioredoxin-Disulfide Reductase / Q000378:metabolism*; D013882:Thiosemicarbazones / Q000737:chemistry*
chemical_list: D004791:Enzyme Inhibitors; D013882:Thiosemicarbazones; D006046:Gold; D013880:Thioredoxin-Disulfide Reductase