title: Concise enantioselective construction of a bridged azatricyclic framework via domino semipinacol-Schmidt reaction.
abstract: A TiCl(4)-promoted domino semipinacol-Schmidt reaction of oxaspiropentane-azide provides an easy access to bridged azatricyclic ring systems, which possess the azaquaternary center, present in the immunosupressant FR901483 and platelet aggregation inhibitor daphlongeranine B.
authors.affiliation: Department of Chemistry, Indian Institute of Technology Madras, Chennai, 600036, India.
authors.forename: Manohar
authors.initials: M
authors.lastname: Puppala
authors.forename: Annamalai
authors.initials: A
authors.lastname: Murali
authors.forename: Sundarababu
authors.initials: S
authors.lastname: Baskaran
mesh_terms: D000470:Alkaloids / Q000737:chemistry; D001372:Aza Compounds / Q000737:chemistry*; D001386:Azides / Q000737:chemistry; D018360:Crystallography, X-Ray; D053138:Cyclohexenes / Q000737:chemistry*; D008968:Molecular Conformation; D009943:Organophosphorus Compounds / Q000737:chemistry; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry; D013237:Stereoisomerism; D014025:Titanium / Q000737:chemistry*
chemical_list: D000470:Alkaloids; D001372:Aza Compounds; D001386:Azides; D053138:Cyclohexenes; C098358:FR 901483; D009943:Organophosphorus Compounds; D010975:Platelet Aggregation Inhibitors; C522226:daphlongeranine B; C519041:semipinacol; C025096:titanium tetrachloride; D014025:Titanium