title: Polymorphisms in genes HSD17B1 and HSD17B2 and uterine leiomyoma risk in Chinese women.
abstract: OBJECTIVE
  To evaluate the association of HSD17B1 and HSD17B2 gene polymorphisms with uterine leiomyoma in Chinese women.
  
  
  METHODS
  121 Chinese women with clinically diagnosed uterine leiomyoma and 217 healthy normal Chinese women were investigated to compare three single nucleotide polymorphisms (SNPs) (rs605059 and rs676387 of HSD17B1 gene and rs8191246 of HSD17B2 gene) by polymerase chain reaction-restriction fragment length polymorphism and DNA sequencing method.
  
  
  RESULTS
  All the SNPs were polymorphisms in Chinese women. Frequencies of rs605059 AA genotype and A allele were significantly increased in patients with uterine leiomyoma compared to healthy controls (GG vs. AA, OR 0.40, 95 % CI 0.20-0.82; G vs. A, OR 0.68, 95 % CI 0.50-0.94).
  
  
  CONCLUSIONS
  The results suggest that the genotype of HSD17B1 rs605059 may play a role in the tumourgenesis of uterine leiomyoma.
authors.affiliation: Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, 610041, Sichuan, China.
authors.forename: Rui-Juan
authors.initials: RJ
authors.lastname: Cong
authors.forename: Zhong-Ying
authors.initials: ZY
authors.lastname: Huang
authors.forename: Ling
authors.initials: L
authors.lastname: Cong
authors.forename: Yi
authors.initials: Y
authors.lastname: Ye
authors.forename: Zheng
authors.initials: Z
authors.lastname: Wang
authors.forename: Lagabaiyila
authors.initials: L
authors.lastname: Zha
authors.forename: Li-Ping
authors.initials: LP
authors.lastname: Cao
authors.forename: Xiao-Wei
authors.initials: XW
authors.lastname: Su
authors.forename: Jing
authors.initials: J
authors.lastname: Yan
authors.forename: Ying-Bi
authors.initials: YB
authors.lastname: Li
mesh_terms: D000328:Adult; D000368:Aged; D044466:Asian People; D016022:Case-Control Studies; D002681:China; D004960:Estradiol Dehydrogenases / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D007889:Leiomyoma / Q000235:genetics*; D008875:Middle Aged; D020641:Polymorphism, Single Nucleotide; D014594:Uterine Neoplasms / Q000235:genetics*
chemical_list: D004960:Estradiol Dehydrogenases; C513331:HSD17B1 protein, human; C523763:HSD17B2 protein, human