title: Synthesis, characterization and biological activity of transition metal complexes with Schiff bases derived from 2-nitrobenzaldehyde with glycine and methionine.
abstract: Schiff bases derived from 2-nitrobenzaldehyde with amino acids (glycine, methionine) and their Co(II), Ni(II) and Cu(II) complexes have been synthesized and characterized by various physico-chemical techniques. From spectral studies, it has been concluded that the ligands acts as bidentate molecule, coordinates metal through azomethine nitrogen and carboxylate oxygen. Mass spectrum explains the successive degradation of the molecular species in solution and justifies ML(2) complexes. X-ray powder diffraction helps to determine the cell parameters of the complexes. Molecular structure of the complexes has been optimized by MM2 calculations and suggests a square planar geometry. The ligands and their metal complexes have been tested in vitro against Streptococcus, Staph, Staphylococcus aureus and Escherchia coli bacteria in order to assess their antibacterial potential. The results indicate that the biological activity increases on complexation.
authors.affiliation: Inorganic & Bioinorganic Research Lab, Department of Chemistry, Govt. Post Graduate College, Ranikhet 263645 (Uttarakhand), India. bibheshksingh@yahoo.co.in
authors.forename: Bibhesh K
authors.initials: BK
authors.lastname: Singh
authors.forename: Hemant K
authors.initials: HK
authors.lastname: Rajour
authors.forename: Anant
authors.initials: A
authors.lastname: Prakash
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001547:Benzaldehydes / Q000737:chemistry*; D004583:Electrons; D005998:Glycine / Q000737:chemistry*; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008715:Methionine / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D008968:Molecular Conformation; D012545:Schiff Bases / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D028561:Transition Elements / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D014961:X-Ray Diffraction
chemical_list: D000900:Anti-Bacterial Agents; D001547:Benzaldehydes; D008024:Ligands; D012545:Schiff Bases; D028561:Transition Elements; C043850:2-nitrobenzaldehyde; D008715:Methionine; D005998:Glycine