title: Association between circulating DNA, serum (1->3)-β-D-glucan, and pulmonary fungal burden in Pneumocystis pneumonia.
abstract: Circulating Pneumocystis jirovecii DNA and (1→3)-β-d-glucan determined in 70 serum samples from immunocompromised patients were compared to fungal load in bronchoalveolar lavage fluids assessed using quantitative polymerase chain reaction. Both serum biomarkers are influenced by pulmonary fungal load, which should be taken into account when diagnosing Pneumocystis infection.
authors.affiliation: Laboratoire de Parasitologie-Mycologie, Hôpital Henri Mondor (AP-HP), Créteil, France.
authors.forename: Jean-Marc
authors.initials: JM
authors.lastname: Costa
authors.forename: Françoise
authors.initials: F
authors.lastname: Botterel
authors.forename: Odile
authors.initials: O
authors.lastname: Cabaret
authors.forename: Françoise
authors.initials: F
authors.lastname: Foulet
authors.forename: Catherine
authors.initials: C
authors.lastname: Cordonnier
authors.forename: Stéphane
authors.initials: S
authors.lastname: Bretagne
mesh_terms: D015415:Biomarkers / Q000097:blood; D001992:Bronchoalveolar Lavage Fluid / Q000382:microbiology*; D015331:Cohort Studies; D015169:Colony Count, Microbial; D004271:DNA, Fungal / Q000097:blood*; D006801:Humans; D016867:Immunocompromised Host; D045363:Pneumocystis carinii / Q000737:chemistry / Q000235:genetics / Q000302:isolation & purification*; D011020:Pneumonia, Pneumocystis / Q000175:diagnosis / Q000382:microbiology / Q000473:pathology*; D011509:Proteoglycans; D012189:Retrospective Studies; D047071:beta-Glucans / Q000097:blood*
chemical_list: D015415:Biomarkers; D004271:DNA, Fungal; D011509:Proteoglycans; D047071:beta-Glucans; C010770:polysaccharide-K