title: Synthesis, DNA-binding, DNA-photonuclease profiling and antimicrobial activity of novel tetra-aza macrocyclic Ni(II), Co(II) and Cu(II) complexes constrained by thiadiazole.
abstract: A new tetra-aza macrocyclic ligand, L (C(24)H(16)N(12)O(2)S(4)) and its complexes of type, [MLCl(2)] and [CuL]Cl(2) (where M=Ni(II), Co(II); L=N,N'-(benzene-1,3-diyldi-1,3,4-thiadiazole-5,2-diyl)bis{2-[(5-benzene-1,3-diyl-1,3,4-thiadiazol-2-yl)amino]acetamide}) were synthesized and characterized by the spectral and analytical techniques. An octahedral geometry has been proposed for Ni(II) and Co(II) complexes while Cu(II) complex exhibit a square planar geometry. All the synthesized metal complexes were screened for their in vitro antimicrobial activity against selected species of pathogenic bacteria and fungi. The binding property of the complexes with CT-DNA was studied by absorption spectral analysis, followed by viscosity measurement and thermal denaturation studies. The photo induced cleavage studies revealed that the complexes possess photonuclease property against pUC19 DNA under UV-visible irradiation.
authors.affiliation: Department of Studies and Research in Industrial Chemistry, School of Chemical Sciences, Kuvempu University, Shankaraghatta 577 451, India.
authors.forename: B
authors.initials: B
authors.lastname: Vinay Kumar
authors.forename: H S
authors.initials: HS
authors.lastname: Bhojya Naik
authors.forename: D
authors.initials: D
authors.lastname: Girija
authors.forename: N
authors.initials: N
authors.lastname: Sharath
authors.forename: S M
authors.initials: SM
authors.lastname: Pradeepa
authors.forename: H
authors.initials: H
authors.lastname: Joy Hoskeri
authors.forename: M C
authors.initials: MC
authors.lastname: Prabhakara
mesh_terms: D000042:Absorption / Q000187:drug effects; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D003035:Cobalt / Q000494:pharmacology; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D003300:Copper / Q000494:pharmacology; D004247:DNA / Q000378:metabolism*; D003851:Deoxyribonucleases / Q000378:metabolism*; D004553:Electric Conductivity; D004583:Electrons; D005658:Fungi / Q000187:drug effects; D008024:Ligands; D008027:Light; D047028:Macrocyclic Compounds / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009532:Nickel / Q000494:pharmacology; D009691:Nucleic Acid Denaturation / Q000187:drug effects; D010957:Plasmids / Q000378:metabolism; D013055:Spectrophotometry, Infrared; D013696:Temperature; D013830:Thiadiazoles / Q000737:chemistry*; D014783:Viscosity / Q000187:drug effects
chemical_list: D000890:Anti-Infective Agents; D056831:Coordination Complexes; D008024:Ligands; D047028:Macrocyclic Compounds; D013830:Thiadiazoles; D003035:Cobalt; D003300:Copper; D009532:Nickel; D004247:DNA; C427203:calf thymus DNA; D003851:Deoxyribonucleases