title: Full-Length Enrich c-DNA Libraries-Clear Cell-Renal Cell Carcinoma.
abstract: Clear cell renal cell carcinoma (ccRCC), the most common subtype of RCC, is characterized by high metastasis potential and strong resistance to traditional therapies, resulting in a poor five-year survival rate of patients. Several therapies targeted to VEGF pathway for advanced RCC have been developed, however, it still needs to discover new therapeutic targets for treating RCC. Genome-wide gene expression analyses have been broadly used to identify unknown molecular mechanisms of cancer progression. Recently, we applied the oligo-capping method to construct the full-length cDNA libraries of ccRCC and adjacent normal kidney, and analyzed the gene expression profiles by high-throughput sequencing. This paper presents a review for recent findings on therapeutic potential of MYC pathway and nicotinamide N-methyltransferase for the treatment of RCC.
authors.affiliation: Institute of Biochemistry and Molecular Biology, College of Medicine, National Taiwan University, No. 1 Jen-Ai Road First Section, Taipei 100, Taiwan.
authors.forename: Sai-Wen
authors.initials: SW
authors.lastname: Tang
authors.forename: Jung-Yaw
authors.initials: JY
authors.lastname: Lin