title: Higher expression of Caveolin-1 inhibits human small cell lung cancer (SCLC) apoptosis in vitro.
abstract: Small cell lung cancer (SCLC) is the most aggressive type of lung cancer, and its treatment is closely associated with apoptosis. Caveolin-1 plays an important role in the development of a variety of human cancers. This study sought to investigate the influence of Caveolin-1 on the apoptosis of SCLC in vitro. We demonstrate that higher expression of Caveolin-1 leads to inhibition of cisplatin and Ultraviolet Radiation (UVR)-induced apoptosis in SCLC cells; and also could decrease caspase-3 activity and increase the stability of Bcl-2 at the protein level. Our findings illuminate a potential molecular mechanism regarding CAV-1's role as anti-apoptosis protein.
authors.affiliation: Department of Histology and Embryology, Dalian Medical University, Dalian, China.
authors.forename: Xiaohan
authors.initials: X
authors.lastname: Yang
authors.forename: Hai
authors.initials: H
authors.lastname: Xiong
authors.forename: Zhu-zhu
authors.initials: ZZ
authors.lastname: Guan
authors.forename: Isaac
authors.initials: I
authors.lastname: Okai
authors.forename: Dongmei
authors.initials: D
authors.lastname: Ye
authors.forename: Yang
authors.initials: Y
authors.lastname: Song
authors.forename: Xiao
authors.initials: X
authors.lastname: Li
authors.forename: Lan
authors.initials: L
authors.lastname: Wang
authors.forename: Lu
authors.initials: L
authors.lastname: Liu
authors.forename: Sha
authors.initials: S
authors.lastname: Du
authors.forename: Dongmei
authors.initials: D
authors.lastname: Lin
authors.forename: Shujuan
authors.initials: S
authors.lastname: Shao
mesh_terms: D000230:Adenocarcinoma; D000077192:Adenocarcinoma of Lung; D017209:Apoptosis / Q000187:drug effects / Q000528:radiation effects; D053148:Caspase 3 / Q000096:biosynthesis; D051242:Caveolin 1 / Q000378:metabolism*; D045744:Cell Line, Tumor; D002945:Cisplatin / Q000494:pharmacology; D015536:Down-Regulation; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism*; D055752:Small Cell Lung Carcinoma / Q000378:metabolism*
chemical_list: D051242:Caveolin 1; D053148:Caspase 3; D002945:Cisplatin