title: [Distribution of structural polymorphisms of angiotensin-converting enzyme and serotonin receptor 5-HT2A genes among long-livers of North-Western Russia].
abstract: In the group of long-livers of the North-West of Russia, I/D polymorphism of angiotensin-converting enzyme (ACE) gene and C102T polymorphism of serotonin receptor (5-HT2A) gene were studied. No reliable differences in allele frequency of these genes between long-livers and young people were detected. Nevertheless, highly pronounced difference in the A1/A2 allele frequency of 5-HT2A gene between populations of the North-West of Russia, on the one hand, and of the USA, on the other hand, was discovered (i.e. 0.397(A1), 0.603(A2), and 0.615(A1), 0.385(A2), respectively). Differences of this kind between the two populations deserve special consideration, conditioning the necessity of further detailed analysis of other genes of the serotonin system in the populations of other regions of Russia.
authors.forename: T Iu
authors.initials: TIu
authors.lastname: Smirnova
authors.forename: D L
authors.initials: DL
authors.lastname: Spivak
authors.forename: G S
authors.initials: GS
authors.lastname: Iakupova
authors.forename: A G
authors.initials: AG
authors.lastname: Zakharchuk
authors.forename: I M
authors.initials: IM
authors.lastname: Spivak
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure / Q000235:genetics*; D003863:Depression / Q000235:genetics / Q000378:metabolism; D005260:Female; D005787:Gene Frequency; D055106:Genome-Wide Association Study; D006801:Humans; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D044348:Receptors, Serotonin, 5-HT2 / Q000235:genetics*; D012084:Renin-Angiotensin System / Q000235:genetics; D012426:Russia; D012701:Serotonin / Q000378:metabolism; D009435:Synaptic Transmission / Q000235:genetics
chemical_list: D044348:Receptors, Serotonin, 5-HT2; D012701:Serotonin; D007703:Peptidyl-Dipeptidase A