title: Treating prepartum depression to improve infant developmental outcomes: a study of diabetes in pregnancy.
abstract: Whether and how the co-occurrence of depression and diabetes in pregnancy may worsen infant development has not been reported. Pregnant women with diabetes and with (n = 34) or without (n = 34) major depressive disorder (MDD) were followed during pregnancy and 6-months postpartum. The MDD subset received randomly assigned treatment with cognitive behavior therapy (CBT) or supportive counseling (SC). Depression severity was measured with the Beck Depression Inventory (BDI); infant developmental outcomes were measured with the Bayley Scales of Infant Development (BSID) and its Behavior Rating Scale (BRS). Infants of women with MDD had lower BRS scores (p = .02). Reduction in depression scores was associated with better infant outcomes on the BSID and BRS (p values <.03). These preliminary findings suggest depression occurring in pregnant women with diabetes is associated with poorer infant development and improvement in prepartum depression is associated with improvement in measures of infant development.
authors.affiliation: Department of Psychiatry, Washington University School of Medicine, 660 S. Euclid, Medical School Box 8134, St. Louis, MO 63110, USA.
authors.forename: Tassy
authors.initials: T
authors.lastname: Hayden
authors.forename: Dana C
authors.initials: DC
authors.lastname: Perantie
authors.forename: Billy D
authors.initials: BD
authors.lastname: Nix
authors.forename: Linda D
authors.initials: LD
authors.lastname: Barnes
authors.forename: Dorothea J
authors.initials: DJ
authors.lastname: Mostello
authors.forename: William L
authors.initials: WL
authors.lastname: Holcomb
authors.forename: Dragan M
authors.initials: DM
authors.lastname: Svrakic
authors.forename: Jeffrey F
authors.initials: JF
authors.lastname: Scherrer
authors.forename: Patrick J
authors.initials: PJ
authors.lastname: Lustman
authors.forename: Tamara
authors.initials: T
authors.lastname: Hershey
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D002657:Child Development; D016241:Child of Impaired Parents; D015928:Cognitive Behavioral Therapy; D015897:Comorbidity; D003376:Counseling; D003865:Major Depressive Disorder / Q000453:epidemiology / Q000628:therapy*; D005260:Female; D006801:Humans; D007223:Infant; D008137:Longitudinal Studies; D008297:Male; D008923:Missouri; D010349:Patient Compliance / Q000523:psychology*; D010865:Pilot Projects; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000453:epidemiology / Q000628:therapy*; D011613:Psychotherapy / Q000379:methods*; D012648:Self Care / Q000523:psychology*