title: Mesenchymal stem cell-based tumor-targeted gene therapy in gastrointestinal cancer.
abstract: Mesenchymal stem (or stromal) cells (MSCs) are nonhematopoietic progenitor cells that can be obtained from bone marrow aspirates or adipose tissue, expanded and genetically modified in vitro, and then used for cancer therapeutic strategies in vivo. Here, we review available data regarding the application of MSC-based tumor-targeted therapy in gastrointestinal cancer, provide an overview of the general history of MSC-based gene therapy in cancer research, and discuss potential problems associated with the utility of MSC-based therapy such as biosafety, immunoprivilege, transfection methods, and distribution in the host.
authors.affiliation: Department of Surgery, University of Munich, Campus Großhadern, Munich, Germany.
authors.forename: Qi
authors.initials: Q
authors.lastname: Bao
authors.forename: Yue
authors.initials: Y
authors.lastname: Zhao
authors.forename: Hanno
authors.initials: H
authors.lastname: Niess
authors.forename: Claudius
authors.initials: C
authors.lastname: Conrad
authors.forename: Bettina
authors.initials: B
authors.lastname: Schwarz
authors.forename: Karl-Walter
authors.initials: KW
authors.lastname: Jauch
authors.forename: Ralf
authors.initials: R
authors.lastname: Huss
authors.forename: Peter J
authors.initials: PJ
authors.lastname: Nelson
authors.forename: Christiane J
authors.initials: CJ
authors.lastname: Bruns
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D060846:Cell Engineering / Q000379:methods; D049109:Cell Proliferation; D005770:Gastrointestinal Neoplasms / Q000628:therapy*; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors / Q000378:metabolism; D006801:Humans; D059630:Mesenchymal Stem Cells / Q000378:metabolism / Q000502:physiology*; D019076:Transgenes