title: Telangiectatic osteosarcoma.
abstract: Osteosarcoma is one of the most common primary malignant bone tumors in children and adolescents. Telangiectatic osteosarcoma is an unusual variant of osteosarcoma, forming 3% to 10% of all osteosarcomas. Radiographically, these tumors appear as purely lytic destructive lesions located in the metaphyses of long bones. The location and x-ray appearance of telangiectatic osteosarcomas are reminiscent of an aneurysmal bone cyst and can test the acumen of a diagnostic radiologist. Distinguishing between the two entities microscopically can also be quite challenging. Telangiectatic osteosarcoma shows dilated blood-filled spaces lined or traversed by septa containing atypical stromal cells, with or without production of a lacelike osteoid matrix. This review highlights the diagnostic features of telangiectatic osteosarcoma and discusses differential diagnostic considerations, treatment options, and prognostic implications.
authors.affiliation: Department of Pathology, University of Utah Health Sciences Center, 50 N Medical Dr, Salt Lake City, UT 84132, USA. nikhil_sangle@yahoo.com
authors.forename: Nikhil A
authors.initials: NA
authors.lastname: Sangle
authors.forename: Lester J
authors.initials: LJ
authors.lastname: Layfield
mesh_terms: D000293:Adolescent; D001859:Bone Neoplasms / Q000473:pathology*; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D012516:Osteosarcoma / Q000473:pathology*; D013684:Telangiectasis / Q000473:pathology*; D055815:Young Adult