title: Measurement of Haemophilus influenzae type a capsular polysaccharide antibodies in cord blood sera.
abstract: We measured anti-Haemophilus influenzae type a capsular polysaccharide serum immunoglobulin G antibodies in cord blood sera from Mexican (n = 68) and Chilean mothers (n = 72) by enzyme-linked immunosorbent assay. Measurable antibodies were found in 79.3% of samples. Immunoglobulin G antibodies correlated with serum bactericidal activity (r = 0.66). This enzyme-linked immunosorbent assay can be used for the evaluation of adaptive immune responses to Haemophilus influenzae type a and serosurveillance studies in populations at risk.
authors.affiliation: Division of Bacterial Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
authors.forename: Daniel S
authors.initials: DS
authors.lastname: Schmidt
authors.forename: Kathryn T
authors.initials: KT
authors.lastname: Bieging
authors.forename: Patricia
authors.initials: P
authors.lastname: Gomez-de-León
authors.forename: Alberto
authors.initials: A
authors.lastname: Villaseñor-Sierra
authors.forename: Jaime
authors.initials: J
authors.lastname: Inostroza
authors.forename: John B
authors.initials: JB
authors.lastname: Robbins
authors.forename: Rachel
authors.initials: R
authors.lastname: Schneerson
authors.forename: George M
authors.initials: GM
authors.lastname: Carlone
authors.forename: Sandra
authors.initials: S
authors.lastname: Romero-Steiner
mesh_terms: D000907:Antibodies, Bacterial / Q000097:blood*; D016667:Bacterial Capsules / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D005260:Female; D005312:Fetal Blood / Q000737:chemistry* / Q000276:immunology; D006192:Haemophilus Infections / Q000276:immunology*; D006193:Haemophilus influenzae / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D026901:Membrane Transport Proteins; D011247:Pregnancy; D012680:Sensitivity and Specificity; D015610:Serum Bactericidal Test; D018709:Statistics, Nonparametric
chemical_list: D000907:Antibodies, Bacterial; C511954:HcsB protein, Haemophilus influenzae; D007074:Immunoglobulin G; D026901:Membrane Transport Proteins