title: RET finger protein expression is associated with prognosis in lung cancer with epidermal growth factor receptor mutations.
abstract: The RET finger protein (RFP) is a transcription factor belonging to the TRIM (tripartite motif) superfamily of proteins. RFP is expressed in a variety of human and rodent tumor cell lines and in several kinds of human cancer. Expression of RFP is associated with prognosis of colon and endometrial cancers. In the present study, we evaluated the expression of RFP in lung cancer and assessed its clinical significance. Tissue microarrays were constructed from 108 cases of lung cancer, and the sections were analyzed for RFP expression by immunohistochemistry. RFP expression was detected in the nucleus in 66.7% of lung cancer tissues examined. RFP expression was statistically significantly associated with thyroid transcription factor 1 (TTF-1) expression (P= 0.028). However, no significant association was observed between RFP expression and other clinicopathological or genetic factors, including epidermal growth factor receptor (EGFR) mutations. Interestingly, we found that RFP expression correlated with poor prognosis in patients with EGFR mutations (P= 0.032). Our results suggest that RFP has a role in mutated EGFR signaling and that RFP status may be a prognostic factor for lung cancer with EGFR mutations.
authors.affiliation: Department of Pathology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
authors.forename: Akari
authors.initials: A
authors.lastname: Iwakoshi
authors.forename: Yoshiki
authors.initials: Y
authors.lastname: Murakumo
authors.forename: Takuya
authors.initials: T
authors.lastname: Kato
authors.forename: Aya
authors.initials: A
authors.lastname: Kitamura
authors.forename: Shinji
authors.initials: S
authors.lastname: Mii
authors.forename: Shoji
authors.initials: S
authors.lastname: Saito
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Yatabe
authors.forename: Masahide
authors.initials: M
authors.lastname: Takahashi
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000378:metabolism / Q000556:secondary; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000378:metabolism / Q000556:secondary; D002467:Cell Nucleus / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000378:metabolism*; D066246:ErbB Receptors / Q000235:genetics* / Q000378:metabolism; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000378:metabolism; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D009367:Neoplasm Staging; D009687:Nuclear Proteins / Q000378:metabolism*; D011379:Prognosis; D015398:Signal Transduction; D046888:Tissue Array Analysis; D000070584:Tripartite Motif Proteins
chemical_list: D004268:DNA-Binding Proteins; D066246:ErbB Receptors; D009687:Nuclear Proteins; C064419:TRIM27 protein, human; D000070584:Tripartite Motif Proteins