title: Visual neglect as a disconnection syndrome? A confirmatory case report.
abstract: Visual neglect has classically been associated with right hemisphere injury in parietal, frontal, or temporal cortex, in the basal ganglia or in the thalamus. More recently, visual neglect has been associated with injury extended into fronto-parietal white matter tracts. However, in most published cases white and gray matter injuries were associated. We present the anatomo-clinical study of a patient presenting with severe acute left visual neglect due to ischemic infarct limited to the right cerebral hemisphere white matter. Magnetic resonance diffusion tensor imaging tractography was instrumental to accurately localize the injury to the right arcuate fasciculus that is a component of the large-scale networks controlling visuo-spatial attention. These results add to a growing appreciation that neglect may result from disruption of a distributed attentional network.
authors.affiliation: Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
authors.forename: Francesca
authors.initials: F
authors.lastname: Ciaraffa
authors.forename: Gianmarco
authors.initials: G
authors.lastname: Castelli
authors.forename: Eugenio Agostino
authors.initials: EA
authors.lastname: Parati
authors.forename: Paolo
authors.initials: P
authors.lastname: Bartolomeo
authors.forename: Alberto
authors.initials: A
authors.lastname: Bizzi
mesh_terms: D001921:Brain / Q000473:pathology*; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology; D038524:Diffusion Magnetic Resonance Imaging; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010468:Perceptual Disorders / Q000150:complications / Q000473:pathology*