title: Antibodies against the gH/gL/UL128/UL130/UL131 complex comprise the majority of the anti-cytomegalovirus (anti-CMV) neutralizing antibody response in CMV hyperimmune globulin.
abstract: Anti-cytomegalovirus (anti-CMV) hyperimmune globulin (HIG) has demonstrated efficacy in preventing CMV disease in solid-organ transplant patients as well as congenital disease when administered to pregnant women. To identify the neutralizing component of cytomegalovirus hyperimmune globulin (CMV-HIG), we performed serial depletions of CMV-HIG on cell-surface-expressed CMV antigens as well as purified antigens. Using this approach, we demonstrate that the major neutralizing antibody response is directed at the gH/gL/UL128/UL130/UL131 complex, suggesting little role for anti-gB antibodies in CMV-HIG neutralization.
authors.affiliation: Department of Infectious Diseases, Genentech, Inc., South San Francisco, California, USA.
authors.forename: Ashley E
authors.initials: AE
authors.lastname: Fouts
authors.forename: Pamela
authors.initials: P
authors.lastname: Chan
authors.forename: Jean-Philippe
authors.initials: JP
authors.lastname: Stephan
authors.forename: Richard
authors.initials: R
authors.lastname: Vandlen
authors.forename: Becket
authors.initials: B
authors.lastname: Feierbach
mesh_terms: D057134:Antibodies, Neutralizing / Q000276:immunology*; D000914:Antibodies, Viral / Q000276:immunology*; D003587:Cytomegalovirus / Q000276:immunology*; D005260:Female; D006801:Humans; D007106:Immune Sera / Q000276:immunology*; D014764:Viral Proteins / Q000276:immunology*
chemical_list: D057134:Antibodies, Neutralizing; D000914:Antibodies, Viral; D007106:Immune Sera; D014764:Viral Proteins