title: P53 and bcl-2 immunoexpression in patients with oral lichen planus  and oral squamous cell carcinoma.
abstract: OBJECTIVE
  The aim of this study was to determine by immunohistochemistry the presence and significance of p53 and bcl-2 proteins in oral lichen planus (OLP) and oral squamous cell carcinoma (OSCC).
  
  
  METHODS
  We used 21 cases diagnosed as OLP 16 diagnosed as OSCC and four normal gingival biopsies taken from healthy patients were used as controls. Slides were processed for immunohistochemistry using anti-p53 and anti-bcl-2 monoclonal antibodies.
  
  
  RESULTS
  We found p53 immunoexpression in 71.4% OLP cases and 68.7% OSCC cases, with no immunoexpression in control cases. Bcl-2 was negative for all OLP and OSCC cases, and mild positivity was observed in normal tissue. We found significant correlation among p53 expression and OSCC malignancy.
  
  
  CONCLUSIONS
  Our results suggest that TP53 system mainly promotes a hyperproliferative state by cell cycle arrest of the OLP epithelial cells for repairing damaged DNA nor apoptosis and that anti-apoptotic action of bcl-2 is not important in this disease.
authors.affiliation: Clinical and Experimental Pathology Laboratory, División de Estudios de Posgrado e Investigación, Facultad de Odontología, UNAM, Ciprés #169-2, Col. Vergel-Coapa, México, 14320. D.F, Mexico.
authors.forename: Elba-Rosa
authors.initials: ER
authors.lastname: Leyva-Huerta
authors.forename: Constantino
authors.initials: C
authors.lastname: Ledesma-Montes
authors.forename: Rebeca-Estela
authors.initials: RE
authors.lastname: Rojo-Botello
authors.forename: Elisa
authors.initials: E
authors.lastname: Vega-Memije
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000276:immunology* / Q000378:metabolism; D005260:Female; D006801:Humans; D017676:Lichen Planus, Oral / Q000276:immunology* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000276:immunology* / Q000378:metabolism; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis / Q000276:immunology*; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis / Q000276:immunology*; D055815:Young Adult
chemical_list: D019253:Proto-Oncogene Proteins c-bcl-2; D016159:Tumor Suppressor Protein p53