title: F2C2: a fast tool for the computation of flux coupling in genome-scale metabolic networks.
abstract: BACKGROUND
  Flux coupling analysis (FCA) has become a useful tool in the constraint-based analysis of genome-scale metabolic networks. FCA allows detecting dependencies between reaction fluxes of metabolic networks at steady-state. On the one hand, this can help in the curation of reconstructed metabolic networks by verifying whether the coupling between reactions is in agreement with the experimental findings. On the other hand, FCA can aid in defining intervention strategies to knock out target reactions.
  
  
  RESULTS
  We present a new method F2C2 for FCA, which is orders of magnitude faster than previous approaches. As a consequence, FCA of genome-scale metabolic networks can now be performed in a routine manner.
  
  
  CONCLUSIONS
  We propose F2C2 as a fast tool for the computation of flux coupling in genome-scale metabolic networks. F2C2 is freely available for non-commercial use at https://sourceforge.net/projects/f2c2/files/.
authors.affiliation: Department of Bioinformatics, Institute for Biochemistry and Biology, University of Potsdam, Karl-Liebknecht-Str, 24-25, D-14476 Potsdam, Germany. Larhlimi@mpimp-golm.mpg.de
authors.forename: Abdelhalim
authors.initials: A
authors.lastname: Larhlimi
authors.forename: Laszlo
authors.initials: L
authors.lastname: David
authors.forename: Joachim
authors.initials: J
authors.lastname: Selbig
authors.forename: Alexander
authors.initials: A
authors.lastname: Bockmayr
mesh_terms: D000465:Algorithms; D019295:Computational Biology / Q000379:methods*; D016678:Genome / Q000235:genetics*; D053858:Metabolic Networks and Pathways / Q000235:genetics*; D008954:Models, Biological; D012984:Software