title: Hepatitis B immune globulin in liver transplantation prophylaxis: an update.
abstract: BACKGROUND
  Liver transplantation is the best treatment option for end-stage liver disease following hepatitis B (HBV) infection. However, the high rate of recurrence of HBV infection following transplantation is a disadvantage of this option.
  
  
  METHODS
  Over the past 2 decades, the gold standard of prophylactic treatment for the prevention of HBV re-infection following liver transplantation has been the administration of low- to high-dose hepatitis B immune globulin (HBIg) along with an antiviral agent to induce passive immunity.
  
  
  RESULTS
  The effectiveness of HBIg in preventing the recurrence of HBV depends on the dosage, route of administration, and duration of HBIg treatment, and the viremic status at the time of transplantation. There is currently no consensus on a standardized recommendation for therapeutic options that include HBIg administration.
  
  
  CONCLUSIONS
  This review attempts to summarize the available data on the feasibility of such options. Most recent studies support the use of long-term combination therapy of HBIg and antiviral NAs (especially new agents).
authors.affiliation: Iranian Hepatitis Network, Tehran, IR Iran.
authors.forename: Payam
authors.initials: P
authors.lastname: Dindoost
authors.forename: Seyed Mohammad
authors.initials: SM
authors.lastname: Jazayeri
authors.forename: Seyed Moayed
authors.initials: SM
authors.lastname: Alavian