title: Fibrin sealants in orthopaedic surgery: practical experiences derived from use of QUIXIL® in total knee arthroplasty.
abstract: BACKGROUND
  Total knee arthroplasty is associated with a significant postoperative blood loss even without any form of perioperative anticoagulation.
  
  
  METHODS
  The potential role of QUIXIL(®), a fibrin sealant used in orthopaedic surgery to control blood loss and avoid blood transfusions in patients undergoing total knee arthroplasty was evaluated in a prospective randomized trial with twenty-four patients diagnosed with primary osteoarthritis of the knee.
  
  
  RESULTS
  Results showed that application of 2 ml QUIXIL(®) adds costs to treatment without reducing the number of transfused red blood cell counts and postoperative haemoglobin loss. However, significant lower levels of postoperative fluid loss (P = 0.026) was detected in QUIXIL(®) treated patients.
  
  
  CONCLUSIONS
  Regarding cost effectiveness and benefit no indication for the use of 2 ml QUIXIL(®) fibrin sealant in standard knee arthroplasty could be proofed statistically.
authors.affiliation: Department of Orthopaedics, University Tübingen, Hoppe-Seyler-Str. 3, 72076, Tübingen, Germany.
authors.forename: Torsten
authors.initials: T
authors.lastname: Kluba
authors.forename: Katrin
authors.initials: K
authors.lastname: Fiedler
authors.forename: Beate
authors.initials: B
authors.lastname: Kunze
authors.forename: Ingmar
authors.initials: I
authors.lastname: Ipach
authors.forename: Andreas
authors.initials: A
authors.lastname: Suckel
mesh_terms: D000368:Aged; D019645:Arthroplasty, Replacement, Knee / Q000379:methods*; D005260:Female; D015718:Fibrin Tissue Adhesive; D006801:Humans; D008297:Male; D011446:Prospective Studies; D016037:Single-Blind Method
chemical_list: D015718:Fibrin Tissue Adhesive