title: Immunohistochemical identification and localisation of gastrin and somatostatin in endocrine cells of human pyloric gastric mucosa.
abstract: The detailed description of the distribution of endocrine cells G and D producing important hormones that regulate activation of other cells in the human stomach may be a valuable source of information for opinions about mucosa changes in different diseases of the alimentary tract. The density and distribution of immunoreactive G and D cells in the pylorus of humans (donors of organs) were evaluated. The pylorus samples were collected after other organs were harvested for transplantation. The number of G cells in the pyloric mucosa of healthy people was higher than the number of D cells. G and D cells were distributed between columnar cells of epithelium mucosa. Multiform endocrine cells generally occurred: gastrin in the middle third of the mucosa and somatostatin cells in the basal half of  the pyloric mucosa. The investigation of the pyloric part of the healthy human  stomach showed a characteristic distribution of cells that reacted with antisera against gastrin and somatostatin.
authors.affiliation: Department of Histology and Cytophysiology, Medical University of Bialystok, Poland. kasacka@umwb.edu.pl
authors.forename: I
authors.initials: I
authors.lastname: Kasacka
authors.forename: W
authors.initials: W
authors.lastname: Łebkowski
authors.forename: I
authors.initials: I
authors.lastname: Janiuk
authors.forename: J
authors.initials: J
authors.lastname: Łapińska
authors.forename: A
authors.initials: A
authors.lastname: Lewandowska
mesh_terms: D000328:Adult; D000368:Aged; D019858:Enteroendocrine Cells / Q000166:cytology / Q000276:immunology / Q000378:metabolism*; D005260:Female; D005753:Gastric Mucosa / Q000166:cytology / Q000276:immunology / Q000378:metabolism*; D005755:Gastrins / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D011708:Pylorus / Q000166:cytology / Q000276:immunology / Q000378:metabolism*; D013004:Somatostatin / Q000276:immunology / Q000378:metabolism*; D055815:Young Adult
chemical_list: D005755:Gastrins; D013004:Somatostatin