title: [Chronic hepatitis C and insulin resistance].
abstract: Insulin resistance is frequently associated with chronic liver disease, and the interaction between hepatitis C virus (HCV) infection and insulin resistance is a major public health issue, bound to increase in the near term. Because of their potential synergism on liver disease severity, a better understanding of the clinical consequences of the relationship between HCV infection and insulin resistance is needed. This translates into accelerated liver disease progression, reduced response to anti-viral agents and, in susceptible individuals, increased risk of developing type 2 diabetes. HCV may also cause hepatic steatosis, especially in patients infected with genotype 3, although the clinical impact of viral steatosis is debated. Little is known regarding the effect of anti-diabetic agents on HCV infection, and a possible association between use of exogenous insulin or a sulfonylurea agents and the development of hepatocellular carcinoma has recently been reported. Thus, modified lifestyle and pharmacological modalities are urgently warranted in chronic hepatitis C with metabolic alterations.
authors.affiliation: Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea. chung50@dsmc.or.kr
authors.forename: Woo Jin
authors.initials: WJ
authors.lastname: Chung
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000188:drug therapy / Q000378:metabolism; D005838:Genotype; D019698:Hepatitis C, Chronic / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use; D007333:Insulin Resistance; D008103:Liver Cirrhosis / Q000209:etiology; D008113:Liver Neoplasms / Q000209:etiology; D013453:Sulfonylurea Compounds / Q000627:therapeutic use
chemical_list: D000998:Antiviral Agents; D007004:Hypoglycemic Agents; D007328:Insulin; D013453:Sulfonylurea Compounds