title: Impact of adenotonsillectomy on high-sensitivity C-reactive protein levels in obese children with obstructive sleep apnea.
abstract: OBJECTIVE
  To evaluate the effect of adenotonsillectomy (T&A) in obese children with obstructive sleep apnea (OSA) and to compare changes in high-sensitivity C-reactive protein (hs-CRP) levels before and 6 months after T&A in obese children with OSA.
  
  
  METHODS
  Before and after study with planned data collection.
  
  
  METHODS
  Tertiary care, university-based pediatric hospital.
  
  
  METHODS
  Seventy-five obese children with OSA were included. Clinical information such as the apnea-hypopnea index (AHI), nadir oxyhemoglobin saturation (SaO(2)), and body mass index (BMI) were recorded. The hs-CRP level was determined before T&A and at the 6-month follow-up examination.
  
  
  RESULTS
  Reductions in AHI (21.96 ± 9.277 before T&A vs 8.64 ± 5.997 after 6 months of T&A) and higher levels of nadir SaO(2) (74.08 ± 7.860 before T&A vs 86.87 ± 5.586 after 6 months of T&A) were observed. The hs-CRP levels were obviously correlated with BMI (r = 0.7948, P < .001). Other than AHI (r = 0.0579, P = .6217) in obese children, however, hs-CRP levels showed no changes 6 months after T&A therapy.
  
  
  CONCLUSIONS
  T&A treatment improves clinical signs and symptoms in obese children but does not reduce chronic inflammation as reflected by hs-CRP. To lower the risks of cardiovascular disease and diabetes mellitus morbidity, other treatments should be taken into account.
authors.affiliation: Chongqing Medical University, Chongqing, China.
authors.forename: Lijuan
authors.initials: L
authors.lastname: Chu
authors.forename: Hongbing
authors.initials: H
authors.lastname: Yao
authors.forename: Bing
authors.initials: B
authors.lastname: Wang
mesh_terms: D000233:Adenoidectomy; D015992:Body Mass Index; D002097:C-Reactive Protein / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006938:Hyperlipoproteinemia Type II; D008297:Male; D009765:Obesity / Q000097:blood* / Q000150:complications*; D010108:Oxyhemoglobins / Q000032:analysis; D017286:Polysomnography; D011183:Postoperative Complications / Q000097:blood; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000601:surgery*; D014068:Tonsillectomy
chemical_list: D010108:Oxyhemoglobins; D002097:C-Reactive Protein