title: Gastroesophageal reflux in cystic fibrosis: current understandings of mechanisms and management.
abstract: Cystic fibrosis (CF) is an inherited disease that affects both the lungs and the digestive system in children and adults. Thick mucus fills the gut and blocks lumens of the pancreas and hepatobiliary systems, creating insufficient pancreas function and liver disease. Chronic gastrointestinal (GI) complications, including intestinal obstruction, occur in neonates, and poor digestion and gastroesophageal reflux disease (GERD) in children. Although GI symptoms tend to improve with age, CF and associated GERD eventually create respiratory insufficiency; the only available treatment option at this stage is a bilateral lung transplant, which carries considerable morbidity and mortality. While GERD may reoccur as a complication of lung transplantation, GERD symptoms are often reduced following a fundoplication.
authors.affiliation: Center for Advanced Research in Neuromuscular Gastrointestinal Disorders, The Ohio State University, Nationwide Children's Hospital, Columbus, OH 43205, USA. hayat.mousa@nationwidechildrens.org
authors.forename: Hayat M
authors.initials: HM
authors.lastname: Mousa
authors.forename: Frederick W
authors.initials: FW
authors.lastname: Woodley
mesh_terms: D003550:Cystic Fibrosis / Q000150:complications* / Q000601:surgery; D050782:Esophageal pH Monitoring; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D006801:Humans; D016040:Lung Transplantation / Q000009:adverse effects