title: [Diplopia and left palpebral ptosis as a first manifestation of hypophysary metastases of pulmonary adenocarcinoma].
abstract: A patient, without significant previous medical history, who started with diplopia and left palpebral ptosis as the first manifestation of hypophysary metastases of a widely disseminated and previously undetected cancer of pulmonary origin. Together with a histological study of the lesions, the diagnosis was made with specific image tests of the hypophysary area, which detected a neoformation in the sella turca that was invading the left cavernous sinus with erosion of the verso of the sellar, together with the presence of pulmonary nodules and numerous adenopathies. An hypogonadotropic hypogonadism was detected as the only hormonal alteration due to the infiltration of the anterior hypophysis due to the osseous metastases at the base of the cranium. The patient, in spite of receiving several weeks of radiotherapy, suffered a progressive neurological deterioration and died after a few weeks.
authors.affiliation: Servicio de Endocrinología, Complejo Hospitalario de Navarra, Pamplona, Spain. sojuba@hotmail.com
authors.forename: S
authors.initials: S
authors.lastname: Junquera
authors.forename: J
authors.initials: J
authors.lastname: Verdún
authors.forename: M C
authors.initials: MC
authors.lastname: Bacaicoa
authors.forename: M
authors.initials: M
authors.lastname: Mendigaña
authors.forename: J
authors.initials: J
authors.lastname: Lafita
mesh_terms: D000230:Adenocarcinoma / Q000150:complications* / Q000175:diagnosis / Q000556:secondary*; D001763:Blepharoptosis / Q000209:etiology*; D004172:Diplopia / Q000209:etiology*; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000556:secondary*