title: Multifocal choroid plexus papilloma: a case report.
abstract: BACKGROUND
  Multiple choroid plexus papillomas (CPPs) are rare. Usually, they correspond to villous hypertrophy or metastasis occurring during cerebrospinal dissemination. Multiple CPPs have rarely been reported as synchronous tumors.
  
  
  METHODS
  Three synchronous CPPs were resected in a 59-year-old female 6 years after their first imaging description. Pathology showed mucus-producing CPP in all 3, 1 of the 3 presenting some signs of atypia. No p53 or hSNF5/INI1 mutation, or signs of polyoma viruses infection were found.
  
  
  CONCLUSIONS
  Although no clear cause for the multifocality was found, the simultaneous presence of the three tumors and their benign histology suggest that they were synchronous and not metastatic. The issue of differentiating synchronous CPPs from metastatic CPP is discussed.
authors.affiliation: Department of Neurosurgery, Westmead Hospital, Darcy Road, Westmead, Australia. martin.scholsem@yahoo.com
authors.forename: Martin
authors.initials: M
authors.lastname: Scholsem
authors.forename: Felix
authors.initials: F
authors.lastname: Scholtes
authors.forename: Pierre A
authors.initials: PA
authors.lastname: Robe
authors.forename: Elettra
authors.initials: E
authors.lastname: Bianchi
authors.forename: Jérome
authors.initials: J
authors.lastname: Kroonen
authors.forename: Manuel
authors.initials: M
authors.lastname: Deprez
mesh_terms: D005260:Female; D006801:Humans; D006850:Hydrocephalus, Normal Pressure / Q000150:complications / Q000601:surgery; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000150:complications / Q000473:pathology*; D020288:Papilloma, Choroid Plexus / Q000150:complications / Q000473:pathology*; D017287:Ventriculoperitoneal Shunt