title: Mineralization regulation and biological influence of bioactive glass-collagen-phosphatidylserine composite scaffolds.
abstract: Biomimetic scaffolds are appealing products for the repair of bone defects using tissue engineering strategies. In the present study, novel biomimetic composite scaffolds, with similar properties to natural bone, were prepared, blended and cross-linked with bioactive glass, type I collagen and phosphatidylserine. When exposed to cell culture solution in the absence of a cellular source, the composite scaffolds form crystals with octahedral structure. These crystals are similar to the products derived from MC3T3-E1 cell mineralization within the composite scaffolds, with respect to both composition and morphology. Furthermore, crystals with octahedral structure were observed to develop into plate-like hydroxyapatite. The bio-mineralization behavior of the composite scaffolds is likely influenced by inorganic components. Finally, a rabbit tibia defect model shows that the highly bioactive properties of the investigated composites result in excellent bone repair.
authors.affiliation: Department of Materials Science and Engineering, Fujian University of Technology, Fuzhou 350108, China. lambmeo@163.com
authors.forename: ChunRong
authors.initials: C
authors.lastname: Yang
authors.forename: YingJun
authors.initials: Y
authors.lastname: Wang
authors.forename: XiaoFeng
authors.initials: X
authors.lastname: Chen
mesh_terms: D016475:3T3 Cells; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry; D001861:Bone Regeneration; D018786:Bone Substitutes / Q000737:chemistry; D001842:Bone and Bones / Q000473:pathology; D024042:Collagen Type I / Q000378:metabolism; D003460:Crystallization; D005898:Glass / Q000737:chemistry*; D051379:Mice; D008855:Microscopy, Electron, Scanning / Q000379:methods; D010718:Phosphatidylserines / Q000737:chemistry; D011817:Rabbits; D013977:Tibia / Q000473:pathology; D013997:Time Factors; D023822:Tissue Engineering / Q000379:methods; D054457:Tissue Scaffolds
chemical_list: D001672:Biocompatible Materials; D018786:Bone Substitutes; D024042:Collagen Type I; D010718:Phosphatidylserines