title: Erlotinib-induced acute interstitial lung disease associated with extreme elevation of the plasma concentration in an elderly non-small-cell lung cancer patient.
abstract: We herein describe a case of drug-induced interstitial lung disease (ILD) following treatment with erlotinib. The plasma trough concentration of erlotinib at the time of the ILD diagnosis was extremely elevated compared with the plasma maximum concentration on day 1. We hypothesized that this phenomenon was associated with the pharmacodynamic interaction with a concomitant drug. The present case indicates that erlotinib-induced ILD was associated with a high plasma concentration of erlotinib. Oncologists should be aware of the possibility of ILD induced by erlotinib, especially for patients with co-morbidities.
authors.affiliation: Department of Internal Medicine, Division of Clinical Oncology and Respiratory Medicine, Shimane University Faculty of Medicine, Izumo, Shimane, Japan. ytsubata@med.shimane-u.ac.jp
authors.forename: Yukari
authors.initials: Y
authors.lastname: Tsubata
authors.forename: Akinobu
authors.initials: A
authors.lastname: Hamada
authors.forename: Akihisa
authors.initials: A
authors.lastname: Sutani
authors.forename: Takeshi
authors.initials: T
authors.lastname: Isobe
mesh_terms: D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D002289:Carcinoma, Non-Small-Cell Lung / Q000150:complications* / Q000188:drug therapy; D000069347:Erlotinib Hydrochloride; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000175:diagnosis*; D008175:Lung Neoplasms / Q000150:complications* / Q000188:drug therapy; D008297:Male; D047428:Protein Kinase Inhibitors / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D011799:Quinazolines / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D047428:Protein Kinase Inhibitors; D011799:Quinazolines; D000069347:Erlotinib Hydrochloride