title: Mate tea prevents oxidative stress in the blood and hippocampus of rats with acute or chronic ethanol administration.
abstract: OBJECTIVE
  The aim of this study was to evaluate the influence of acute and chronic intake of mate tea on the effects elicited by acute and chronic administration of ethanol.
  
  
  METHODS
  Oxidative stress was evaluated by measuring thiobarbituric acid-reactive substances (TBARS), as well as the activities of the antioxidant enzymes, catalase (CAT), glutathione peroxidase (GSH-Px), and superoxide dismutase (SOD) in the hippocampus and blood of rats. Male Wistar rats were randomly assigned to four groups, for both acute and chronic treatment: (1) control group, (2) treated group, (3) intoxicated group, (4) and intoxicated group treated with mate tea.
  
  
  RESULTS
  Both ethanol administrations significantly increased TBARS in plasma and hippocampus of rats and altered antioxidant enzyme activities, changes which were reverted by mate tea administration.
  
  
  CONCLUSIONS
  Data indicate that acute and chronic ethanol administration induced oxidative stress in hippocampus and blood and that mate tea treatment was able to prevent this situation.
authors.affiliation: Centro de Ciências Exatas e Naturais, Departamento de Ciências Naturais, Universidade Regional de Blumenau, Blumenau, SC, Brazil. deboradelwing@furb.br
authors.forename: Bianca
authors.initials: B
authors.lastname: Scolaro
authors.forename: Daniela
authors.initials: D
authors.lastname: Delwing-de Lima
authors.forename: José Geraldo Pereira
authors.initials: JG
authors.lastname: da Cruz
authors.forename: Débora
authors.initials: D
authors.lastname: Delwing-Dal Magro
mesh_terms: D000818:Animals; D002374:Catalase / Q000032:analysis / Q000097:blood; D000431:Ethanol / Q000633:toxicity*; D005979:Glutathione Peroxidase / Q000032:analysis / Q000097:blood; D006624:Hippocampus / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008297:Male; D018384:Oxidative Stress / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000032:analysis / Q000097:blood; D013662:Tea / Q000737:chemistry*; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis
chemical_list: D010936:Plant Extracts; D013662:Tea; D017392:Thiobarbituric Acid Reactive Substances; D000431:Ethanol; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase