title: Impact of a transfusion-related acute lung injury reduction strategy on apheresis platelet collections.
abstract: BACKGROUND
  Most blood centers in the US have implemented transfusion-related acute lung injury (TRALI) mitigation strategies for apheresis platelet (AP) donations based on theoretical impact of donor loss. The aim of this study is to determine the actual impact of a TRALI mitigation strategy in a US blood center.
  
  
  METHODS
  Daily collection events and resulting products were retrospectively obtained before and after implementation of a TRALI reduction strategy (HLA antibody testing female AP donors four or more pregnancies) for comparison. The retention rate of reassigned donors was determined by reviewing whole blood (WB) and/or apheresis red blood cell (AR) donations post reassignment. Data were obtained to compare donor frequency and split rate from reassigned (historical data) and new AP donors.
  
  
  RESULTS
  Mean daily collections (27.7 vs. 30.0) and total products (12,211 vs. 12,957) were significantly higher after implementation, but the number of products/collection event was lower (1.49 vs. 1.40). Mean collections/donor/year (4.0 vs. 1.8) and split rate (36% vs. 27%) were historically higher for reassigned (n = 45) versus new AP donors (n = 1,090). Seventy-three of 112 donors (65%) testing positive for HLA antibodies returned for WB or AR donations, 31 of 45 (69%) active AP donors returned.
  
  
  CONCLUSIONS
  Donor loss may not be adequate to estimate impact on AP inventory, as donation characteristics may differ between new donors and those reassigned. We show successful implementation of a TRALI mitigation strategy by increasing collection goals and AP donor recruitment efforts beyond donor loss. Retaining the majority of reassigned donors is feasible.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of Kentucky Medical Center, Lexington, Kentucky 40536, USA. djwi225@uky.edu
authors.forename: Dennis
authors.initials: D
authors.lastname: Williams
authors.forename: Marepalli
authors.initials: M
authors.lastname: Rao
authors.forename: Patricia
authors.initials: P
authors.lastname: Carey
mesh_terms: D055371:Acute Lung Injury / Q000097:blood / Q000209:etiology* / Q000517:prevention & control*; D001781:Blood Component Removal; D001782:Blood Donors; D017707:Erythrocyte Transfusion; D005260:Female; D006680:HLA Antigens / Q000097:blood; D006801:Humans; D007518:Isoantibodies / Q000097:blood; D009820:Ohio; D010298:Parity / Q000276:immunology; D010949:Plasma / Q000276:immunology; D010983:Plateletpheresis; D011247:Pregnancy; D012189:Retrospective Studies; D065227:Transfusion Reaction
chemical_list: D006680:HLA Antigens; D007518:Isoantibodies