title: The perioperative use of biologic agents in patients with rheumatoid arthritis.
abstract: Biologic drugs have gained an important place in the treatment of rheumatic diseases. These medications may, however, pose a higher risk of infections in rheumatic patients who a priori are prone to infections. The potential consequences of the immunosuppressive effects of the biologics raise concern about their safety in the perioperative setting. This article reviews the scientific literature that examines the influence of biologic drugs on post-surgical complications. According to these studies, it is apparently safe to use tumor necrosis factor-α blockers and the IL-6 receptor blocker, although a few study limitations, such as small sample size, retrospective design and differences in the comparison groups weaken the conclusions. In addition, the recommendations for some of the biologic drugs are based solely on pharmacological parameters due to the absence of trials, and larger randomized controlled studies are needed to establish the safety of their use by patients with rheumatic diseases.
authors.affiliation: Department of Rheumatology, Tel-Aviv Sourasky Medical Center and the Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
authors.forename: Ari
authors.initials: A
authors.lastname: Polachek
authors.forename: Dan
authors.initials: D
authors.lastname: Caspi
authors.forename: Ori
authors.initials: O
authors.lastname: Elkayam
mesh_terms: D018501:Antirheumatic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000188:drug therapy / Q000601:surgery; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism; D001688:Biological Products / Q000009:adverse effects* / Q000627:therapeutic use; D016207:Cytokines / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007431:Intraoperative Complications / Q000209:etiology*; D012216:Rheumatic Diseases / Q000150:complications / Q000188:drug therapy / Q000601:surgery; D014945:Wound Healing / Q000276:immunology
chemical_list: D018501:Antirheumatic Agents; D001688:Biological Products; D016207:Cytokines