title: Effects of an aqueous extract of Orbignya phalerata Mart on locomotor activity and motor coordination in mice and as antioxidant in vitro.
abstract: The antioxidant activities of aqueous extract (AE) of Orbignya phalerata were assessed in vitro as well as its effect on locomotor activity and motor coordination in mice. AE does not possesses a strong antioxidant potential according to the scavenging assays; it also did not present scavenger activity in vitro. Following oral administration, AE (1, 2 and 3 g/kg) did not significantly change the motor activity of animals when compared with the control group, up to 24 h after administration and did not alter the remaining time of the animals on the Rota-rod apparatus. Further studies currently in progress will enable us to understand the mechanisms of action of the aqueous extract of Orbignya phalerata widely used in Brazilian flok medicine.
authors.affiliation: Programa de Pós-graduação em Ciências Farmacêuticas, Núcleo de Tecnologia Farmacêutica, Laboratório de Pesquisa em Neuroquímica Experimental, Universidade Federal do Piauí (NTF/LAPNEX/UFPI), Teresina-Piauí, Brazil.
authors.forename: A P dos S
authors.initials: AP
authors.lastname: Silva
authors.forename: G S
authors.initials: GS
authors.lastname: Cerqueira
authors.forename: L C C
authors.initials: LC
authors.lastname: Nunes
authors.forename: R M
authors.initials: RM
authors.lastname: de Freitas
mesh_terms: D000818:Animals; D028023:Arecaceae / Q000737:chemistry*; D001938:Brazil; D003855:Deoxyribose / Q000378:metabolism; D003975:Diazepam / Q000494:pharmacology; D016166:Free Radical Scavengers / Q000494:pharmacology; D005638:Fruit / Q000737:chemistry; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D008297:Male; D008519:Medicine, Traditional; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D009569:Nitric Oxide / Q000378:metabolism; D010936:Plant Extracts / Q000494:pharmacology; D004856:Postural Balance / Q000187:drug effects*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D016166:Free Radical Scavengers; D006993:Hypnotics and Sedatives; D010936:Plant Extracts; D017392:Thiobarbituric Acid Reactive Substances; D009569:Nitric Oxide; D003855:Deoxyribose; D003975:Diazepam