title: A highly efficient one-pot reaction of 2-(gem-dibromovinyl)phenols(thiophenols) with K4Fe(CN)6 to 2-cyanobenzofurans(thiophenes).
abstract: 2-Cyanobenzofurans and 2-cyanobenzothiophenes were prepared through an efficient one-pot Ullmann-reaction/cyanation reaction. In the presence of CuI/Na(2)CO(3)-Pd(OAc)(2)/PPh(3) in DMF, the reaction of 2-(gem-dibromovinyl)phenols and 2-(gem-dibromovinyl)thiophenols with K(4)Fe(CN)(6), as non-toxic and user-friendly cyanating reagent, proceeded smoothly to generate the corresponding 2-cyanobenzofurans and 2-cyanobenzothiophenes in good yields.
authors.affiliation: Department of Chemistry, Huaibei Normal University, Huaibei, Anhui 235000, PR China.
authors.forename: Wei
authors.initials: W
authors.lastname: Zhou
authors.forename: Wei
authors.initials: W
authors.lastname: Chen
authors.forename: Lei
authors.initials: L
authors.lastname: Wang
mesh_terms: D001572:Benzofurans / Q000138:chemical synthesis*; D002384:Catalysis; D005295:Ferrocyanides / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry; D010636:Phenols / Q000737:chemistry*; D013876:Thiophenes / Q000138:chemical synthesis*; D014753:Vinyl Compounds / Q000138:chemical synthesis*
chemical_list: D001572:Benzofurans; D005295:Ferrocyanides; D010636:Phenols; D013876:Thiophenes; D014753:Vinyl Compounds; D010165:Palladium; C031835:potassium ferrocyanide