title: Synthesis and X-ray structure analysis of a heptacoordinate titanium(IV)-bis-chelate with enhanced in vivo antitumor efficacy.
abstract: Chelate stabilization of a titanium(IV)-salan alkoxide by ligand exchange with 2,6-pyridinedicarboxylic acid (dipic) resulted in heptacoordinate complex 3 which is not redox-active, stable on silica gel and has increased aqueous stability. 3 is highly toxic in HeLa S3 and Hep G2 and has enhanced antitumor efficacy in a mouse cervical-cancer model.
authors.affiliation: Fachbereich Chemie and Konstanz Research School Chemical Biology, Universität Konstanz, Universitätsstr. 10, D-78457 Konstanz, Germany.
authors.forename: Timo A
authors.initials: TA
authors.lastname: Immel
authors.forename: Martin
authors.initials: M
authors.lastname: Grützke
authors.forename: Anne-Katrin
authors.initials: AK
authors.lastname: Späte
authors.forename: Ulrich
authors.initials: U
authors.lastname: Groth
authors.forename: Peter
authors.initials: P
authors.lastname: Öhlschläger
authors.forename: Thomas
authors.initials: T
authors.lastname: Huhn
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D056831:Coordination Complexes / Q000737:chemistry* / Q000627:therapeutic use / Q000633:toxicity; D018360:Crystallography, X-Ray; D004195:Disease Models, Animal; D005260:Female; D006367:HeLa Cells; D056945:Hep G2 Cells; D006801:Humans; D008024:Ligands; D051379:Mice; D008968:Molecular Conformation; D058428:Silica Gel / Q000737:chemistry; D014025:Titanium / Q000737:chemistry*; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents; D056831:Coordination Complexes; D008024:Ligands; D058428:Silica Gel; D014025:Titanium