title: Reproducibility of brain dopamine transporter binding with Tc-99m TRODAT-1 SPECT in healthy young men.
abstract: Single photon emission computed tomography (SPECT) with Tc-99m TRODAT-1 as ligand can be used to evaluate striatal dopamine transporters (DAT) in young subjects. The purpose of this study was to evaluate the reproducibility of (99m)Tc-TRODAT-1 SPECT in DAT binding in healthy young men. Fourteen healthy young men were recruited. The test-retest studies were performed 1week apart. Specific uptake ratios (SUR) of the striatum (ST) and its subregions, the caudate (CA) and the putamen (PU), were measured using the occipital cortex as the reference tissue. The reliability of the two measurements between test and retest, showed significant correlations for the ST, CA and PU, was demonstrated by calculating the intraclass correlation coefficient (ICC). Thus, (99m)Tc-TRODAT-1 SPECT might provide a reproducible and reliable tool in clinical management of young patients with DAT-related disorders.
authors.affiliation: Graduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan.
authors.forename: Chin-Bin
authors.initials: CB
authors.lastname: Yeh
authors.forename: Yuan-Hwa
authors.initials: YH
authors.lastname: Chou
authors.forename: Cheng-Yi
authors.initials: CY
authors.lastname: Cheng
authors.forename: Meei-Shyuan
authors.initials: MS
authors.lastname: Lee
authors.forename: Jhi-Joung
authors.initials: JJ
authors.lastname: Wang
authors.forename: Chiang-Hsuan
authors.initials: CH
authors.lastname: Lee
authors.forename: Chyng-Yann
authors.initials: CY
authors.lastname: Shiue
authors.forename: Tung-Ping
authors.initials: TP
authors.lastname: Su
authors.forename: Wen-Sheng
authors.initials: WS
authors.lastname: Huang
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging*; D050483:Dopamine Plasma Membrane Transport Proteins / Q000378:metabolism*; D006801:Humans; D016014:Linear Models; D008297:Male; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics*; D011485:Protein Binding / Q000187:drug effects; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D015203:Reproducibility of Results; D015899:Tomography, Emission-Computed, Single-Photon; D014326:Tropanes / Q000493:pharmacokinetics*; D055815:Young Adult
chemical_list: D050483:Dopamine Plasma Membrane Transport Proteins; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D014326:Tropanes; C104196:technetium Tc 99m TRODAT-1