title: Screening for toxicity and resistance to paralytic shellfish toxin of shore crabs inhabiting at Leizhou peninsula, China.
abstract: The situation of the environment contaminated by paralytic shellfish toxin (PST) in Leizhou peninsula, China, has attracted more attention since seafood poisoning occurred occasionally. In this study, we examined the toxicities of shore crab Leptodius exaratus, Thalamita crenata and Metopograpsus latifrons by mouse assay, resistance to PST by lethal test injection with PST, and discussed the toxicity neutralization of their hemolymph. The results showed 12% of shore crabs possessed toxicity of 4.3-4.4 MU/g. The 100% lethal dose of PST for M. latifrons was about 2 times of those for the other two crab species. The hemolymphs of the crabs were all able to neutralize PST and tetrodotoxin (TTX) toxicity in different extent. The above results indicate shore crabs at this area are exposed to an environment potentially contaminated with PST and/or TTX, and the toxicity neutralizing efficacy of their hemolymph directly affects their resistance to the toxins.
authors.affiliation: College of Food Science and Technology, Guangdong Ocean University, Zhanjiang 524088, China.
authors.forename: Huajuan
authors.initials: H
authors.lastname: Lin
authors.forename: Yuji
authors.initials: Y
authors.lastname: Nagashima
authors.forename: Peihong
authors.initials: P
authors.lastname: Jiang
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Qin
authors.forename: Yao
authors.initials: Y
authors.lastname: Lu
authors.forename: Chaohua
authors.initials: C
authors.lastname: Zhang
mesh_terms: D000818:Animals; D003386:Brachyura; D006458:Hemolymph / Q000737:chemistry*; D008297:Male; D008387:Marine Toxins / Q000633:toxicity*; D051379:Mice
chemical_list: D008387:Marine Toxins