title: Gene expression profiling in acute Stanford type B aortic dissection.
abstract: OBJECTIVE
  To compare the gene expression profiles of the aorta specimens between patients with Stanford type B aortic dissection (AD) and controls.
  
  
  METHODS
  Samples of descending aorta were collected from patients with type B AD (n = 12) and from multiorgan donors as controls (n = 12). Phalanx whole genome microarray was used to analyze differential gene expression.
  
  
  RESULTS
  Of the 6375 probes validated, 623 genes were found to be differentially expressed between patients with type B AD and controls (fold change ≥2). Gene ontology analysis identified significantly enriched gene groups pertaining to cell-cell adhesion, extracellular matrix, cell-matrix adhesion, cytoskeleton, immune and inflammatory response, and apoptosis.
  
  
  CONCLUSIONS
  Genes encoding components related to integrity and strength of the aortic wall were downregulated, whereas those related to inflammatory response were upregulated in type B AD. The altered patterns of gene expression indicate preexisting structural defects that are probably a consequence of insufficient remodeling of the aortic wall.
authors.affiliation: Department of vascular surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
authors.forename: Lixin
authors.initials: L
authors.lastname: Wang
authors.forename: Lei
authors.initials: L
authors.lastname: Yao
authors.forename: Daqiao
authors.initials: D
authors.lastname: Guo
authors.forename: Chunsheng
authors.initials: C
authors.lastname: Wang
authors.forename: Bo
authors.initials: B
authors.lastname: Wan
authors.forename: Guoqing
authors.initials: G
authors.lastname: Ji
authors.forename: Cheng
authors.initials: C
authors.lastname: Yang
authors.forename: Jing
authors.initials: J
authors.lastname: Zhang
authors.forename: Zaozhuo
authors.initials: Z
authors.lastname: Sheng
authors.forename: Weiguo
authors.initials: W
authors.lastname: Fu
authors.forename: Yuqi
authors.initials: Y
authors.lastname: Wang
mesh_terms: D000328:Adult; D000784:Aortic Dissection / Q000235:genetics* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D001014:Aortic Aneurysm / Q000235:genetics* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D016022:Case-Control Studies; D002681:China; D016000:Cluster Analysis; D005260:Female; D020869:Gene Expression Profiling / Q000379:methods; D005786:Gene Expression Regulation; D053263:Gene Regulatory Networks; D006801:Humans; D008297:Male; D008875:Middle Aged; D020411:Oligonucleotide Array Sequence Analysis; D060888:Real-Time Polymerase Chain Reaction