title: Application of carbon nanotubes in neurology: clinical perspectives and toxicological risks.
abstract: Nanomedicine is an emerging field that proposes the application of precisely engineered nanomaterials for the prevention, diagnosis and therapy of certain diseases, including neurological pathologies. Carbon nanotubes (CNT) are a new class of nanomaterials, which have been shown to be promising in different areas of nanomedicine. In this review, the application of CNT interfacing with the central nervous system (CNS) will be described, and representative examples of neuroprosthetic devices, such as neuronal implants and electrodes will be discussed. Furthermore, the possible application of CNT-based materials as regenerative matrices of neuronal tissue and as delivery systems for the therapy of CNS will be presented.
authors.affiliation: Nanomedicine Laboratory, UCL School of Pharmacy, University College London, London, UK.
authors.forename: Antonio
authors.initials: A
authors.lastname: Nunes
authors.forename: Khuloud
authors.initials: K
authors.lastname: Al-Jamal
authors.forename: Takeshi
authors.initials: T
authors.lastname: Nakajima
authors.forename: Marwan
authors.initials: M
authors.lastname: Hariz
authors.forename: Kostas
authors.initials: K
authors.lastname: Kostarelos
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000187:drug effects / Q000502:physiology / Q000503:physiopathology*; D002491:Central Nervous System Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use; D002493:Central Nervous System Diseases / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy*; D016503:Drug Delivery Systems; D006801:Humans; D050997:Nanomedicine / Q000639:trends; D037742:Nanotubes, Carbon / Q000009:adverse effects / Q000737:chemistry; D058117:Neural Prostheses / Q000639:trends; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D044968:Regenerative Medicine / Q000639:trends
chemical_list: D002491:Central Nervous System Agents; D037742:Nanotubes, Carbon