title: Quinazolino-benzothiazoles: fused pharmacophores as anticonvulsant agents.
abstract: A series of 6-bromo-2-ethyl-3-(substitutedbenzo[d]thiazol-2-yl)quinazolin-4(3H)-one 3 (a-j) were synthesized using appropriate synthetic route and evaluated experimentally by the Maximal Electro Shock (MES) and the PTZ-induced seizure methods. Among the tested compounds, 3-(benzo[d]thiazol-2-yl)-6-bromo-2-ethylquinazolin-4(3H)-one (3a) has shown significant activity against tonic seizure by the MES model and 6-bromo-2-ethyl-3-(6-methoxybenzo[d]thiazol-2-yl)quinazolin-4(3H)-one (3h) against clonic seizure by PTZ-induced seizure model. Not one of the selected compounds demonstrated any sign of neurotoxicity and hepatotoxicity.
authors.affiliation: Department of Pharmaceutical Chemistry, R.C. Patel College of Pharmacy, Shirpur, Dhule 425405, Maharashtra, India. vinod.ugale@rediffmail.com
authors.forename: Vinod G
authors.initials: VG
authors.lastname: Ugale
authors.forename: Harun M
authors.initials: HM
authors.lastname: Patel
authors.forename: Sudhir G
authors.initials: SG
authors.lastname: Wadodkar
authors.forename: Sanjay B
authors.initials: SB
authors.lastname: Bari
authors.forename: Atul A
authors.initials: AA
authors.lastname: Shirkhedkar
authors.forename: Sanjay J
authors.initials: SJ
authors.lastname: Surana
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D052160:Benzothiazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D015195:Drug Design; D004597:Electroshock / Q000009:adverse effects; D008297:Male; D051379:Mice; D010433:Pentylenetetrazole / Q000009:adverse effects; D011799:Quinazolines / Q000737:chemistry*; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy / Q000201:enzymology
chemical_list: D000927:Anticonvulsants; D052160:Benzothiazoles; D011799:Quinazolines; D010433:Pentylenetetrazole