title: The intestinal epithelium tuft cells: specification and function.
abstract: The intestinal epithelium, composed of at least seven differentiated cell types, represents an extraordinary model to understand the details of multi-lineage differentiation, a question that is highly relevant in developmental biology as well as for clinical applications. This review focuses on intestinal epithelial tuft cells that have been acknowledged as a separate entity for more than 60 years but whose function remains a mystery. We discuss what is currently known about the molecular basis of tuft cell fate and differentiation and why elucidating tuft cell function has been so difficult. Finally, we summarize the current hypotheses on their potential involvement in diseases of the gastro-intestinal tract.
authors.affiliation: CNRS UMR5203, 34094, Montpellier, France.
authors.forename: François
authors.initials: F
authors.lastname: Gerbe
authors.forename: Catherine
authors.initials: C
authors.lastname: Legraverend
authors.forename: Philippe
authors.initials: P
authors.lastname: Jay
mesh_terms: D000818:Animals; D015415:Biomarkers / Q000378:metabolism*; D002454:Cell Differentiation; D019070:Cell Lineage; D005767:Gastrointestinal Diseases / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007413:Intestinal Mucosa / Q000166:cytology* / Q000378:metabolism; D008871:Microvilli / Q000378:metabolism
chemical_list: D015415:Biomarkers