title: Evaluation of the 2010 McDonald multiple sclerosis criteria in children with a clinically isolated syndrome.
abstract: BACKGROUND
  Magnetic resonance imaging diagnostic criteria for paediatric multiple sclerosis have been established on the basis of brain imaging findings alone. The 2010 McDonald criteria for the diagnosis of multiple sclerosis, however, include spinal cord imaging for detection of lesion dissemination in space. The new criteria have been recommended in paediatric multiple sclerosis.
  
  
  OBJECTIVE
  (1) To evaluate the 2010 McDonald multiple sclerosis criteria in children with a clinically isolated syndrome and to compare them with recently proposed magnetic resonance criteria for children; (2) to assess whether the inclusion of spinal cord imaging provided additional value to the 2010 McDonald criteria.
  
  
  METHODS
  We performed a retrospective analysis of brain and spinal cord magnetic resonance imaging scans from 52 children with a clinically isolated syndrome. Sensitivity, specificity and accuracy of the magnetic resonance criteria were assessed.
  
  
  CONCLUSIONS
  The 2010 McDonald dissemination in space criteria were more sensitive (85% versus 74%) but less specific (80% versus 100%) compared to the 2005 McDonald criteria. The Callen criteria were more accurate (89%) compared to the 2010 McDonald (85%), the 2005 McDonald criteria for dissemination in space (81%), the KIDMUS criteria (46%) and the Canadian Pediatric Demyelinating Disease Network criteria (76%). The 2010 McDonald criteria for dissemination in time were more accurate (93%) than the dissemination in space criteria (85%). Inclusion of the spinal cord did not increase the accuracy of the McDonald criteria.
authors.affiliation: Department of Neurology, Medical University of Vienna, Austria. Barbara.bajer-kornek@meduniwien.ac.at
authors.forename: Barbara
authors.initials: B
authors.lastname: Kornek
authors.forename: Beate
authors.initials: B
authors.lastname: Schmitl
authors.forename: Karl
authors.initials: K
authors.lastname: Vass
authors.forename: Sonja
authors.initials: S
authors.lastname: Zehetmayer
authors.forename: Martin
authors.initials: M
authors.lastname: Pritsch
authors.forename: Johann
authors.initials: J
authors.lastname: Penzien
authors.forename: Michael
authors.initials: M
authors.lastname: Karenfort
authors.forename: Astrid
authors.initials: A
authors.lastname: Blaschek
authors.forename: Rainer
authors.initials: R
authors.lastname: Seidl
authors.forename: Daniela
authors.initials: D
authors.lastname: Prayer
authors.forename: Kevin
authors.initials: K
authors.lastname: Rostasy
mesh_terms: D001921:Brain / Q000473:pathology*; D002648:Child; D003711:Demyelinating Diseases / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009103:Multiple Sclerosis / Q000175:diagnosis*; D010372:Pediatrics / Q000592:standards; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013116:Spinal Cord / Q000473:pathology*