title: Evolution of transmitted HIV-1 drug resistance in HIV-1-infected patients in Italy from 2000 to 2010.
abstract: Prevalence and predictors of transmitted drug resistance (TDR), defined as the presence of at least one WHO surveillance drug resistance mutation (SDRM), were investigated in antiretroviral-naïve HIV-1-infected patients, with a genotypic resistance test (GRT) performed ≤6 months before starting cART between 2000 and 2010. 3163 HIV-1 sequences were selected (69% subtype B). Overall, the prevalence of TDR was 12% (13.2% subtype B, 9% non-B). TDR significantly declined overall and for the single drug classes. Older age independently predicted increased odds of TDR, whereas a more recent GRT, a higher HIV-RNA and C vs. B subtype predicted lower odds of TDR.
authors.affiliation: Institute of Clinical Infectious Diseases, Catholic University of S. Heart, Rome, Italy. manuela76@inwind.it
authors.forename: M
authors.initials: M
authors.lastname: Colafigli
authors.forename: C
authors.initials: C
authors.lastname: Torti
authors.forename: E M
authors.initials: EM
authors.lastname: Trecarichi
authors.forename: L
authors.initials: L
authors.lastname: Albini
authors.forename: A
authors.initials: A
authors.lastname: Rosi
authors.forename: V
authors.initials: V
authors.lastname: Micheli
authors.forename: N
authors.initials: N
authors.lastname: Manca
authors.forename: G
authors.initials: G
authors.lastname: Penco
authors.forename: B
authors.initials: B
authors.lastname: Bruzzone
authors.forename: G
authors.initials: G
authors.lastname: Punzi
authors.forename: P
authors.initials: P
authors.lastname: Corsi
authors.forename: G
authors.initials: G
authors.lastname: Parruti
authors.forename: P
authors.initials: P
authors.lastname: Bagnarelli
authors.forename: L
authors.initials: L
authors.lastname: Monno
authors.forename: A
authors.initials: A
authors.lastname: Gonnelli
authors.forename: R
authors.initials: R
authors.lastname: Cauda
authors.forename: S
authors.initials: S
authors.lastname: Di Giambenedetto
mesh_terms: D000328:Adult; D019380:Anti-HIV Agents / Q000008:administration & dosage / Q000494:pharmacology*; D024882:Drug Resistance, Viral; D019143:Evolution, Molecular; D005260:Female; D005838:Genotype; D015658:HIV Infections / Q000188:drug therapy / Q000453:epidemiology / Q000635:transmission* / Q000821:virology*; D015497:HIV-1 / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence
chemical_list: D019380:Anti-HIV Agents