title: JDP2 inhibits the epithelial-to-mesenchymal transition in pancreatic cancer BxPC3 cells.
abstract: Pancreatic carcinoma is one of the most malignant and aggressive cancers. Increased motility and invasiveness of pancreatic cancer cells are believed to be associated with epithelial-to-mesenchymal transition (EMT). However, the molecular basis of EMT in pancreatic cancer cells is poorly understood. In this study, we examined the relationship between Jun dimerization protein 2 (JDP2), which is an AP-1 inhibitor, and EMT in human pancreatic carcinoma cells. We demonstrated that transforming growth factor-β1 (TGF-β1) promoted epidermal growth factor (EGF)-induced EMT in co-treated human pancreatic BxPC3 cells and that JDP2 overexpression reversed the EMT that was induced by co-treatment with TGF-β1 and EGF. These results suggest that EGF plays a principal role in EMT through its association with TGF-β1 in human pancreatic BxPC3 cells and that JDP2 may be a molecular target for pancreatic carcinoma intervention.
authors.affiliation: Department of Pancreatic Gastroenterologic Surgery, First Hospital of China Medical University, No. 92, Nanjing Rd, Shenyang, 110001, China.
authors.forename: Zhe
authors.initials: Z
authors.lastname: Liu
authors.forename: Ruixia
authors.initials: R
authors.lastname: Du
authors.forename: Jin
authors.initials: J
authors.lastname: Long
authors.forename: Anbing
authors.initials: A
authors.lastname: Dong
authors.forename: Jianpeng
authors.initials: J
authors.lastname: Fan
authors.forename: Kejian
authors.initials: K
authors.lastname: Guo
authors.forename: Yuanhong
authors.initials: Y
authors.lastname: Xu
mesh_terms: D015820:Cadherins / Q000235:genetics / Q000378:metabolism; D045744:Cell Line, Tumor; D002465:Cell Movement / Q000187:drug effects / Q000235:genetics; D004815:Epidermal Growth Factor / Q000494:pharmacology; D058750:Epithelial-Mesenchymal Transition / Q000187:drug effects / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D006801:Humans; D010190:Pancreatic Neoplasms / Q000235:genetics* / Q000378:metabolism; D012097:Repressor Proteins / Q000235:genetics* / Q000378:metabolism; D053773:Transforming Growth Factor beta1 / Q000494:pharmacology; D014746:Vimentin / Q000235:genetics
chemical_list: D015820:Cadherins; C491387:JDP2 protein, human; D012097:Repressor Proteins; D053773:Transforming Growth Factor beta1; D014746:Vimentin; D004815:Epidermal Growth Factor