title: Nomimicin, a new spirotetronate-class polyketide from an actinomycete of the genus Actinomadura.
abstract: Nomimicin (1), a new spirotetronate-class polyketide, was isolated from the culture broth of an actinomycete of the genus Actinomadura. Its structure was established by spectroscopic methods, and the absolute configuration was determined by a combination of NOESY experiment, J-based configuration analysis and the modified Mosher method. Nomimicin (1) showed antimicrobial activity against Micrococcus luteus, Candida albicans and Kluyveromyces fragilis.
authors.affiliation: Biotechnology Research Center, Toyama Prefectural University, Toyama, Japan. yas@pu-toyama.ac.jp
authors.forename: Yasuhiro
authors.initials: Y
authors.lastname: Igarashi
authors.forename: Takako
authors.initials: T
authors.lastname: Iida
authors.forename: Naoya
authors.initials: N
authors.lastname: Oku
authors.forename: Hiroyuki
authors.initials: H
authors.lastname: Watanabe
authors.forename: Kazuo
authors.initials: K
authors.lastname: Furihata
authors.forename: Koji
authors.initials: K
authors.lastname: Miyanouchi
mesh_terms: D039903:Actinobacteria / Q000378:metabolism*; D000890:Anti-Infective Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D007716:Kluyveromyces / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D016982:Micrococcus luteus / Q000187:drug effects; D008969:Molecular Sequence Data; D061065:Polyketides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012336:RNA, Ribosomal, 16S / Q000235:genetics; D013057:Spectrum Analysis
chemical_list: D000890:Anti-Infective Agents; D061065:Polyketides; D012336:RNA, Ribosomal, 16S; C578273:nomimicin