title: Effect of paeonol on antioxidant and immune regulatory activity in hepatocellular carcinoma rats.
abstract: The study investigated the immunity and antioxidant potential of paeonol by employing a hepatocellular carcinoma (HCC) rat model. Three doses of paeonol (20, 40, 60 mg/kg b.w. orally) were administrated to diethylnitrosamine (DEN)-induced HCC rats. Results showed that paeonol significantly reduced the serum AST, ALT, ALP, GGT, AFU and liver MDA levels, increased serum WBC, TP, ALB, A/G, TNF-α and IFN-γ and liver antioxidant enzymes activities (SOD, CAT, GSH-Px, GR) in HCC rats. Altogether, these results suggest that the paeonol could effectively decrease oxidative injury and improve immunity function in HCC rats.
authors.affiliation: Department of Fifth Hepatic Surgery, Eastern Hepatobiliary Hospital, Second Military Medical University, Shanghai 200438, China.
authors.forename: Bendong
authors.initials: B
authors.lastname: Chen
authors.forename: Mingliang
authors.initials: M
authors.lastname: Ning
authors.forename: Guangshun
authors.initials: G
authors.lastname: Yang
mesh_terms: D000098:Acetophenones / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D016516:CD4-CD8 Ratio; D016207:Cytokines / Q000378:metabolism; D007155:Immunologic Factors / Q000008:administration & dosage / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008111:Liver Function Tests; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D018655:Lymphocyte Count; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000187:drug effects / Q000276:immunology
chemical_list: D000098:Acetophenones; D000975:Antioxidants; D016207:Cytokines; D007155:Immunologic Factors; C013638:paeonol