title: Relationship between poststroke depression and ischemic lesion location.
abstract: BACKGROUND
  Depression is more frequently detected in stroke patient compared to other medical illness with equal disability. The relationship between poststroke depression and ischemic stroke lesion location is controversial.
  
  
  OBJECTIVE
  To determine the relationship between early onset poststroke depression and ischemic stroke lesion location.
  
  
  METHODS
  A cross-sectional analysis was conducted. In-patients diagnosed with first acute ischemic stroke were enrolled. CT scan and MRI of the brain were performed to confirm the diagnosis of ischemic stroke as well as ischemic stroke subtypes and to determine the ischemic stroke lesion locations. Hamilton Depression Rating Scale was used to assess early onset poststroke depression within two weeks after the onset of stroke. Statistical analysis was conducted to determine the relationship between early onset poststroke depression and ischemic stroke lesion location as well as early poststroke depression and other potential factors.
  
  
  RESULTS
  Thirty-nine patients were enrolled. The mean age (+/- SD) is 59.7 (+/- 12.3) years. Male: female ratio was 2:1. Early onset post stroke depression was found in 11 patients (28.2%). Mild depressive, less than major depressive, and major depressive level were found in five patients (12.8%), five patients (12.8%), and one patient (2.6%) respectively. Factors that statistically significantly related to early onset poststroke depression are left sided stroke lesion, female gender and absence of hypertension.
  
  
  CONCLUSIONS
  Left sided stroke lesion, female gender, and absence of hypertension are factors contributing to early onset poststroke depression.
authors.affiliation: Division of Neurology, Department of Internal Medicine, Faculty of Medicine, Srinakharinwirot University, Nakhon Nayok, Thailand. aaaaark@yahoo.com
authors.forename: Monton
authors.initials: M
authors.lastname: Wongwandee
authors.forename: Sookjaroen
authors.initials: S
authors.lastname: Tangwongchai
authors.forename: Kammant
authors.initials: K
authors.lastname: Phanthumchinda
mesh_terms: D000368:Aged; D002545:Brain Ischemia / Q000453:epidemiology*; D015897:Comorbidity; D003430:Cross-Sectional Studies; D003863:Depression / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D020521:Stroke / Q000453:epidemiology* / Q000523:psychology*