title: [Periconceptional toxoplasmic seroconversion: about 79 cases].
abstract: OBJECTIVE
  Toxoplasmosis is a cosmopolitan zoonose led by an intracellular protozoon, Toxoplasma gondii. Severe fetal consequences can be encountered in case of infection during pregnancy. Since 1978, a specific screening program has been implemented in France during pregnancy. The purpose of our study is to evaluate the fetal consequences of a maternal contamination during the periconceptional period.
  
  
  METHODS
  We retrospectively analyzed, over a 10-year period, the outcome of all the pregnancies with a suspicion of periconceptional seroconversion. Periconceptional seroconversion was defined as infection occurring during the two months prior to or following the assumed date of the conception. The obstetric care, the fetal ultrasound scan and the neonatal features were all closely looked at.
  
  
  RESULTS
  Seventy-nine patients (81 fetus) showed evidence of the diagnosis criteria of periconceptional infection. Three cases (3.8%) of congenital infection were observed: two late miscarriages (at 15 weeks and 24 weeks) and one case of an alive child with infraclinic toxoplasmosis.
  
  
  CONCLUSIONS
  In our study, the rate of congenital toxoplasmosis (3.8%) in the event of a periconceptional infection is slightly above the rate previously described in the literature (0.6 to 3.3%). The rate of miscarriage is also high: 66% in case of congenital infection. A regular ultrasound follow-up until the end of the pregnancy is necessary to ensure the best care available. The decision whether to carry out an amniocentesis is discussed in that case.
authors.affiliation: Clinique d'obstétrique, pôle Femme-Mère-Nouveau-né, maternité Jeanne-de-Flandre, CHRU de Lille, avenue Eugène-Avinée, 59037 Lille cedex, France. charles.garabedian@gmail.com
authors.forename: C
authors.initials: C
authors.lastname: Garabedian
authors.forename: J
authors.initials: J
authors.lastname: Le Goarant
authors.forename: L
authors.initials: L
authors.lastname: Delhaes
authors.forename: V
authors.initials: V
authors.lastname: Rouland
authors.forename: P
authors.initials: P
authors.lastname: Vaast
authors.forename: A S
authors.initials: AS
authors.lastname: Valat
authors.forename: D
authors.initials: D
authors.lastname: Subtil
authors.forename: V
authors.initials: V
authors.lastname: Houfflin-Debarge
mesh_terms: D000465:Algorithms; D000649:Amniocentesis; D005260:Female; D005315:Fetal Diseases / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology / Q000276:immunology; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical / Q000706:statistics & numerical data; D008297:Male; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology / Q000276:immunology; D011379:Prognosis; D012189:Retrospective Studies; D016036:Seroepidemiologic Studies; D012698:Serologic Tests; D014123:Toxoplasmosis / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology / Q000635:transmission*; D014125:Toxoplasmosis, Congenital / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology