title: Is serum cystatin C a better marker than serum creatinine for monitoring renal function in pediatric intensive care unit?
abstract: In critically ill patients, mild to moderate reductions in glomerular filtration rate are not instantly followed by parallel changes in serum creatinine (SCr). The aim of this study was to identify a value of serum cystatin C (cys-C) level as a marker for monitoring renal function in critically ill pediatric patients. Creatinine clearance was used to estimate glomeruler filtration rate (eGFR). The correlation between the inverse of serum cys-C and eGFR (r = -0.70, p < 0.0001) was better than the correlation between the inverse of SCr and eGFR (r = -0.27, p = 0.008). Serum cys-C was found to be superior to SCr to predict renal impairment (area under the curve for cys-C, 0.932 and for SCr, 0.658). It can be concluded that cys-C is superior to SCr for the detection of renal impairment in critically ill children.
authors.affiliation: Ondokuz Mayis University School of Medicine, Division of Pediatric Critical Care, Samsun, Turkey. naz.120@hotmail.com
authors.forename: Nazik
authors.initials: N
authors.lastname: Asilioglu
authors.forename: Yonca
authors.initials: Y
authors.lastname: Acikgoz
authors.forename: Muhammet Sukru
authors.initials: MS
authors.lastname: Paksu
authors.forename: Murat
authors.initials: M
authors.lastname: Gunaydin
authors.forename: Ozan
authors.initials: O
authors.lastname: Ozkaya
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood*; D016638:Critical Illness; D055316:Cystatin C / Q000097:blood*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D015278:Intensive Care Units, Pediatric; D007677:Kidney Function Tests / Q000379:methods*; D007902:Length of Stay; D008297:Male; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012372:ROC Curve; D051437:Renal Insufficiency / Q000097:blood* / Q000175:diagnosis / Q000503:physiopathology
chemical_list: D015415:Biomarkers; D055316:Cystatin C; D003404:Creatinine