title: [Chronic migraine: pathophysiology].
abstract: Chronic migraine is considered a complication of episodic migraine. Several risk factors, which may be modifiable or non-modifiable, make varying contributions to the progression towards chronification. Every year 2.5% of patients with episodic migraine go on to suffer chronic migraine. Experimental studies point to a dysfunction in the descending pain modulatory system that would facilitate nociceptive afferents, in the absence of damage to tissues, and so chronic migraine would share a pathogenesis that is similar to that of fibromyalgia, irritable bowel syndrome or chronic tension-type headache (conditions that frequently coexist). This paper reviews the risk factors and the scientific evidence of the possible pathogenic mechanisms involved in the progression towards chronification.
authors.affiliation: Programa de Cefaleas, Servicio de Neurología, Hospital Ruber Internacional, Madrid, España. msanchezdelrio@ruberinternacional.es
authors.forename: Margarita
authors.initials: M
authors.lastname: Sánchez del Río-González
mesh_terms: D001921:Brain / Q000473:pathology / Q000503:physiopathology; D002908:Chronic Disease; D015897:Comorbidity; D005356:Fibromyalgia / Q000453:epidemiology / Q000503:physiopathology; D054092:Foramen Ovale, Patent / Q000150:complications / Q000453:epidemiology / Q000503:physiopathology; D051271:Headache Disorders, Secondary / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D006930:Hyperalgesia / Q000453:epidemiology / Q000503:physiopathology; D007249:Inflammation / Q000453:epidemiology / Q000503:physiopathology; D020766:Intracranial Embolism / Q000209:etiology / Q000503:physiopathology; D043183:Irritable Bowel Syndrome / Q000453:epidemiology / Q000503:physiopathology; D008881:Migraine Disorders / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology*; D019964:Mood Disorders / Q000453:epidemiology / Q000503:physiopathology; D059906:Neuroimaging; D009765:Obesity / Q000453:epidemiology / Q000503:physiopathology; D058748:Pain Perception; D036361:Peptide Hormones / Q000502:physiology; D015995:Prevalence; D012307:Risk Factors; D012891:Sleep Apnea Syndromes / Q000453:epidemiology / Q000503:physiopathology; D013564:Sympathetic Nervous System / Q000503:physiopathology; D014276:Trigeminal Nerve / Q000503:physiopathology
chemical_list: D036361:Peptide Hormones