title: Adipose tissue cells, lipotransfer and cancer: a challenge for scientists, oncologists and surgeons.
abstract: Despite recent evidence of the cancer-promoting role of adipose tissue-derived progenitor and differentiated cells, the use of lipotransfer for tissue/organ reconstruction after surgical removal of cancer is increasing worldwide. Here we discuss in a multidisciplinary fashion the preclinical data connecting obesity, adipose cells and cancer progression, as well as the clinical data concerning safety of lipotransfer procedures in cancer patients. A roadmap towards a more rationale use of lipotransfer in oncology is urgently needed and should include preclinical studies to dissect the roles of different adipose tissue-derived cells, the evaluation of drugs currently candidate to inhibit the interaction between adipose and tumor cells, and carefully designed clinical trials to investigate the safety of lipotransfer procedures in cancer patients.
authors.affiliation: Laboratory of Hematology-Oncology, European Institute of Oncology, Milan, Italy. francesco.bertolini@ieo.it
authors.forename: Francesco
authors.initials: F
authors.lastname: Bertolini
authors.forename: Visnu
authors.initials: V
authors.lastname: Lohsiriwat
authors.forename: Jean-Yves
authors.initials: JY
authors.lastname: Petit
authors.forename: Mikhail G
authors.initials: MG
authors.lastname: Kolonin
mesh_terms: D017667:Adipocytes / Q000166:cytology / Q000473:pathology*; D000273:Adipose Tissue / Q000166:cytology / Q000473:pathology* / Q000637:transplantation*; D006801:Humans; D009369:Neoplasms / Q000209:etiology* / Q000601:surgery; D019651:Plastic Surgery Procedures / Q000009:adverse effects* / Q000379:methods