title: [Immunological monitoring strategies for cytomegalovirus infection. Immune-based therapies].
abstract: T-cell response to cytomegalovirus (CMV) is essential in the control of viral replication. Quantification of functional CD4(+) and CD8(+) T lymphocytes against certain CMV-antigen specificities through flow cytometry, ELISPOT or the QuantiFERON-CMV kit allows fairly accurate estimation of the risk of active infection and CMV disease in solid organ transplantation (SOT). Combined virological and immunological monitoring of CMV infection could allow antiviral treatments to be individually tailored and optimized in SOT, although clinical experience is currently lacking. The adoptive transfer of CMV-specific T cells before selection with multimer HLA peptides or after activation and expansion ex vivo could be an effective therapeutic alternative in the management of active infection or organic CMV disease refractory to antiviral therapy. Several CMV vaccines have been developed, which have been shown to be safe and immunogenic in preclinical and Phase I clinical trials. However, to date, none of these vaccines has been evaluated in Phase III clinical trials and consequently none has been approved for clinical use.
authors.affiliation: Instituto Maimónides de Investigación Biomédica de Córdoba - Hospital Reina Sofía - Universidad de Córdoba, Córdoba, España. sacanti@hotmail.com
authors.forename: Sara
authors.initials: S
authors.lastname: Cantisán Bohórquez
authors.forename: David
authors.initials: D
authors.lastname: Navarro Ortega
mesh_terms: D003586:Cytomegalovirus Infections / Q000097:blood / Q000276:immunology* / Q000628:therapy*; D006801:Humans; D007167:Immunotherapy; D015166:Monitoring, Immunologic; D013601:T-Lymphocytes