title: Haematopoietic stem cell transplantation (HSCT) in severe autoimmune diseases: analysis of UK outcomes from the British Society of Blood and Marrow Transplantation (BSBMT) data registry 1997-2009.
abstract: The British Society of Blood and Marrow Transplantation Data Registry was used to analyse outcomes of haematopoietic stem cell transplantation (HSCT) in severe autoimmune diseases (SADs) from 1997 to 2009. 55 autologous and 15 allogeneic HSCT were registered (0·22% of overall UK HSCT activity). Sustained responses were observed following HSCT, although toxicity was significant. This is the first reported national analysis of long-term outcomes of HSCT in SADs, and should be viewed in the context of translational and developmental phases of HSCT in poor prognosis and refractory SADs. Treatment of poor-risk but reversible SADs with adequate fitness for HSCT in accordance with current guidelines is warranted.
authors.affiliation: Department of Haematology, Sheffield Teaching Hospitals NHS Foundation Trust and Department of Oncology, University of Sheffield, Sheffield, UK. john.snowden@sth.nhs.uk
authors.forename: John A
authors.initials: JA
authors.lastname: Snowden
authors.forename: Rachel M
authors.initials: RM
authors.lastname: Pearce
authors.forename: Julia
authors.initials: J
authors.lastname: Lee
authors.forename: Keiren
authors.initials: K
authors.lastname: Kirkland
authors.forename: Maria
authors.initials: M
authors.lastname: Gilleece
authors.forename: Paul
authors.initials: P
authors.lastname: Veys
authors.forename: Richard E
authors.initials: RE
authors.lastname: Clark
authors.forename: Majid
authors.initials: M
authors.lastname: Kazmi
authors.forename: Mario
authors.initials: M
authors.lastname: Abinun
authors.forename: Graham H
authors.initials: GH
authors.lastname: Jackson
authors.forename: Stephen
authors.initials: S
authors.lastname: Mackinnon
authors.forename: Nigel H
authors.initials: NH
authors.lastname: Russell
authors.forename: Gordon
authors.initials: G
authors.lastname: Cook
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001327:Autoimmune Diseases / Q000401:mortality* / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D012042:Registries; D012189:Retrospective Studies; D012955:Societies, Medical; D015996:Survival Rate; D014184:Transplantation, Homologous; D006113:United Kingdom / Q000453:epidemiology