title: Data on Wistar Hannover rats from an immunotoxicity study.
abstract: The aim of this study was to collect data on immunological parameters from Wistar Hannover rats at 8, 10, 19, and 32 weeks of age. Low leukocyte parameter cell counts, serum globulin concentration, and T, B, and NK lymphocyte counts in peripheral blood at each time point; low T, B, and NK splenocyte counts; and high, or tendencies toward high, thymocyte counts at 10 weeks of age were noted in females when compared with males. KLH-specific antibody production increased gradually with age in both sexes. The immunological data noted for leukocyte parameters, the serum globulin concentration, and immunophenotyping (peripheral blood, spleen, and thymus) relating to chronological changes and sex differences may be useful in assessing drug-related immunotoxicity in this strain.
authors.affiliation: The United Graduate School of Veterinary Science, Yamaguchi University, Yamaguchi 753-8515, Japan.
authors.forename: Hideyuki
authors.initials: H
authors.lastname: Yamatoya
authors.forename: Hiroaki
authors.initials: H
authors.lastname: Kawaguchi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Fukuda
authors.forename: Hidetomi
authors.initials: H
authors.lastname: Kadokura
authors.forename: Rie
authors.initials: R
authors.lastname: Yamashita
authors.forename: Tsuyoshi
authors.initials: T
authors.lastname: Yoshikawa
authors.forename: Mitsuya
authors.initials: M
authors.lastname: Shiraishi
authors.forename: Atsushi
authors.initials: A
authors.lastname: Miyamoto
authors.forename: Noriaki
authors.initials: N
authors.lastname: Miyoshi
mesh_terms: D000818:Animals; D005260:Female; D006433:Hemocyanins / Q000276:immunology; D007107:Immune System / Q000166:cytology* / Q000502:physiology; D007136:Immunoglobulins / Q000097:blood; D016130:Immunophenotyping; D007962:Leukocytes / Q000166:cytology* / Q000276:immunology; D016131:Lymphocyte Subsets / Q000166:cytology / Q000502:physiology; D008297:Male; D051381:Rats; D017208:Rats, Wistar / Q000276:immunology*; D012737:Sex Factors; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology; D018675:Toxicity Tests / Q000379:methods
chemical_list: D007136:Immunoglobulins; D006433:Hemocyanins; C032808:keyhole-limpet hemocyanin