title: [Adipokines: some players of inflammation in inflammatory rheumatic diseases and systemic autoimmune diseases?].
abstract: Adipocytokines or adipokines are a group of molecules (such as leptin, adiponectin, visfatine and resistine) mainly produced by adipose tissue. The adipokines are involved in different physiological processes but their participation to inflammatory and immune responses have been recently described. Their contribution to inflammatory diseases such as chronic inflammatory joint diseases and autoimmune diseases, and osteoarthritis as well, is currently growing, suggesting new pathophysiological schema and treatments. Leptin, visfatin and resistin have pro-inflammatory properties while adiponectin is anti-inflammatory, especially for the vascular wall. Adiponectin is considered to be protective for cardiovascular risk. The influence of the treatments given in inflammatory rheumatic diseases and autoimmune diseases (traditional drugs and biologics) on adipokines requires to be studied.
authors.affiliation: CHU hôpital Saint-Jacques, pôle recherche, centre investigation clinique - biothérapie 506, 25000 Besançon, France. etoussirot@chu-besancon.fr
authors.forename: Eric
authors.initials: E
authors.lastname: Toussirot
mesh_terms: D054392:Adipokines / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology / Q000378:metabolism*; D002356:Cartilage / Q000276:immunology / Q000378:metabolism; D006801:Humans; D007107:Immune System / Q000378:metabolism / Q000502:physiology; D007249:Inflammation / Q000378:metabolism*; D012213:Rheumatic Fever / Q000276:immunology / Q000378:metabolism*
chemical_list: D054392:Adipokines