title: Synthesis and 188Re radiolabelling of dendrimer polyamide amine (PAMAM) folic acid conjugate.
abstract: Folic acid receptors (FR) are usually over expressed in many cancer cells and are considered as potential targeted therapy agent. Generation of five polyamido amine (PAMAM) dendrimer folic acid conjugate was synthesised and radiolabelled with (188)Re, furthermore the in vitro/in vivo stability was evaluated accordingly. The labelling yield of the conjugate G5-FA-DTPA-(188)Re was 67.1% and its radiochemical purity exceeded 95%. The conjugate also showed high in vitro stability and potential value for further structure modifications and evaluations.
authors.affiliation: Shanghai Center for Systems Biomedicine, Ministry of Education Key Laboratory of Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China.
authors.forename: Wei
authors.initials: W
authors.lastname: Cui
authors.forename: Yuanqing
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xiaoping
authors.initials: X
authors.lastname: Xu
authors.forename: Yu-Mei
authors.initials: YM
authors.lastname: Shen
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D050091:Dendrimers / Q000138:chemical synthesis* / Q000737:chemistry*; D004355:Drug Stability; D005492:Folic Acid / Q000138:chemical synthesis* / Q000737:chemistry*; D006801:Humans; D051379:Mice; D015394:Molecular Structure; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000737:chemistry; D012211:Rhenium / Q000737:chemistry*
chemical_list: D001672:Biocompatible Materials; D050091:Dendrimers; C104700:PAMAM Starburst; D019275:Radiopharmaceuticals; D012211:Rhenium; D005492:Folic Acid