title: [Breast cancer in young patient in Morocco].
abstract: OBJECTIVE
  Breast cancer occurring in young women is rare with epidemiological, diagnostic and prognostic characteristics of their own. It is more often linked to genetic predisposition and especially correlated with a lower survival and higher rates of recidivism. The aim of the study was to analyze epidemiological, clinicopathological, biological and evolutionary characteristics.
  
  
  METHODS
  It is a retrospective study concerning 74 patients aged 35 and younger, in whom a diagnosis of invasive breast cancer was made between September 2004 and December 2009.
  
  
  RESULTS
  Incidence of breast cancer in women aged under 35 in our series was 18.6%, mean age was 30.62years and five patients (6.75%) had a family history of breast cancer. The mean tumor size was 3.9±2.6cm; 45.4% of tumors were locally advanced. It was an infiltrating ductal carcinoma of grade III of Scarff-Bloom and Richardson (SBR) in 45.7% cases and half the time it was accompanied by an axillary lymph node involvement. Negative hormone receptor (HR-) was found in only 28.7% of cases and 13 cases overexpressed Her2. Eighteen percent of the tumors were classified as triple negative. The overall survival at 3years was 87.8%.
  
  
  CONCLUSIONS
  The incidence of breast cancer in young Moroccan patients is high. In our context, it is distinguished by a delayed diagnosis explaining the advanced stage at diagnosis. Biological characteristics are often more aggressive, including high histological grade, lack of hormone receptors and the higher rate of triple negative tumours significantly reducing treatment options.
authors.affiliation: Laboratoire d'anatomie pathologique, hôpital des spécialités, CHU Hassan II, Fès, Maroc. Electronic address: kaoutarznati@yahoo.fr.
authors.forename: K
authors.initials: K
authors.lastname: Znati
authors.affiliation: Laboratoire d'anatomie pathologique, hôpital des spécialités, CHU Hassan II, Fès, Maroc.
authors.forename: S
authors.initials: S
authors.lastname: Bennis
authors.affiliation: Laboratoire de molécules bioactives, faculté des sciences et techniques de Fès, Fès, Maroc.
authors.forename: F
authors.initials: F
authors.lastname: Abbass
authors.affiliation: Service d'oncologie médicale, hôpital des spécialités, CHU Hassan II, Fès, Maroc.
authors.forename: Y
authors.initials: Y
authors.lastname: Akasbi
authors.affiliation: Laboratoire d'anatomie pathologique, hôpital des spécialités, CHU Hassan II, Fès, Maroc.
authors.forename: L
authors.initials: L
authors.lastname: Chbani
authors.affiliation: Laboratoire d'anatomie pathologique, hôpital des spécialités, CHU Hassan II, Fès, Maroc.
authors.forename: H
authors.initials: H
authors.lastname: Elfatemi
authors.affiliation: Laboratoire d'anatomie pathologique, hôpital des spécialités, CHU Hassan II, Fès, Maroc.
authors.forename: T
authors.initials: T
authors.lastname: Harmouch
authors.affiliation: Laboratoire d'anatomie pathologique, hôpital des spécialités, CHU Hassan II, Fès, Maroc.
authors.forename: A
authors.initials: A
authors.lastname: Amarti
mesh_terms: D000328:Adult; D001365:Axilla; D001943:Breast Neoplasms / Q000453:epidemiology* / Q000235:genetics / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000453:epidemiology / Q000473:pathology; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D009018:Morocco / Q000453:epidemiology; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate