title: microRNA-206 promotes skeletal muscle regeneration and delays progression of             Duchenne muscular dystrophy in mice.
abstract: Skeletal muscle injury activates adult myogenic stem cells, known as satellite             cells, to initiate proliferation and differentiation to regenerate new muscle fibers.             The skeletal muscle-specific microRNA miR-206 is upregulated in satellite             cells following muscle injury, but its role in muscle regeneration has not been defined.             Here, we show that miR-206 promotes skeletal muscle regeneration in response to injury.             Genetic deletion of miR-206 in mice substantially delayed regeneration induced by             cardiotoxin injury. Furthermore, loss of miR-206 accelerated and exacerbated the             dystrophic phenotype in a mouse model of Duchenne muscular dystrophy. We found that             miR-206 acts to promote satellite cell differentiation and fusion into muscle fibers             through suppressing a collection of negative regulators of myogenesis. Our findings             reveal an essential role for miR-206 in satellite cell differentiation during skeletal             muscle regeneration and indicate that miR-206 slows progression of Duchenne muscular             dystrophy.
authors.affiliation: Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9148, USA. Ning.Liu@utsouthwestern.edu
authors.forename: Ning
authors.initials: N
authors.lastname: Liu
authors.forename: Andrew H
authors.initials: AH
authors.lastname: Williams
authors.forename: Johanna M
authors.initials: JM
authors.lastname: Maxeiner
authors.forename: Svetlana
authors.initials: S
authors.lastname: Bezprozvannaya
authors.forename: John M
authors.initials: JM
authors.lastname: Shelton
authors.forename: James A
authors.initials: JA
authors.lastname: Richardson
authors.forename: Rhonda
authors.initials: R
authors.lastname: Bassel-Duby
authors.forename: Eric N
authors.initials: EN
authors.lastname: Olson
mesh_terms: D000818:Animals; D054715:Cardiotoxins / Q000009:adverse effects / Q000494:pharmacology; D002454:Cell Differentiation; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D035683:MicroRNAs / Q000235:genetics / Q000378:metabolism*; D024510:Muscle Development; D018482:Muscle, Skeletal / Q000293:injuries / Q000378:metabolism* / Q000473:pathology; D020388:Muscular Dystrophy, Duchenne / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D012038:Regeneration; D032496:Satellite Cells, Skeletal Muscle / Q000378:metabolism* / Q000473:pathology
chemical_list: D054715:Cardiotoxins; D035683:MicroRNAs; C540669:Mirn206 microRNA, mouse