title: Angiomyolipomatous hamartoma of the inguinal lymph node--report of two cases and literature review.
abstract: Angiomyolipomatous hamartoma is a variant of angiomyomatous hamartoma (AMH), a rare nodal smooth muscle proliferation, first identified as a distinct entity by Chan et al. in 1992. To date, several cases have been described, mostly involving inguinal lymph nodes. We present two cases of angiomyolipomatous hamartoma, in a 52-year-old male and 67-year-old female patient. Both patients were surgically treated. Microscopically, in the affected nodes, the parenchyma was mostly replaced with bundles of smooth muscle cells, fibrous tissue and lobules of mature adipocytes. Only a few atrophic lymphatic follicles were maintained in the subcapsular area. The presence of smooth muscle cells and endothelial cells was confirmed immunohistochemically by staining for smooth muscle actin, desmin and CD31. The hilus contained numerous thick-walled vessels extending to the medulla. Pleomorphism, mitoses and necrosis were absent. Considering there are no reported recurrences of AMH, it probably has benign behaviour; thus extensive resection may not be needed. Nevertheless, we believe that recognition of AMH is important in the differential diagnosis of other pathological conditions that may affect lymph nodes.
authors.affiliation: Department of Pathology, School of Medicine, University of Zagreb, Šalata 10, Zagreb, Croatia.
authors.forename: Tihana
authors.initials: T
authors.lastname: Dzombeta
authors.forename: Mirela
authors.initials: M
authors.lastname: Francina
authors.forename: Kristijan
authors.initials: K
authors.lastname: Matković
authors.forename: Ivan
authors.initials: I
authors.lastname: Marković
authors.forename: Zoran
authors.initials: Z
authors.lastname: Jukić
authors.forename: Cvjetko
authors.initials: C
authors.lastname: Lez
authors.forename: Bozo
authors.initials: B
authors.lastname: Kruslin
mesh_terms: D000008:Abdominal Neoplasms / Q000175:diagnosis* / Q000473:pathology; D000368:Aged; D018207:Angiomyolipoma / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006222:Hamartoma / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D019042:Muscle Neoplasms / Q000175:diagnosis* / Q000473:pathology; D009130:Muscle, Smooth / Q000473:pathology*