title: Efficacy and safety of propiverine in children with overactive bladder.
abstract: OBJECTIVE
  Antimuscarinic therapy remains one of the most common forms of therapy for overactive bladder (OAB) in children. However, few clinical studies on the outcomes of antimuscarinics in children with OAB have been published. Therefore, we evaluated the efficacy and safety of propiverine, which is frequently prescribed for the treatment of pediatric OAB.
  
  
  METHODS
  We retrospectively reviewed children with OAB treated with propiverine within the past 5 years. The response rates were compared between the non-urge incontinence (non-UI) and urge incontinence (UI groups). The cumulative response rate by treatment duration was also compared between the two groups.
  
  
  RESULTS
  Among a total of 68 children, 50 children (73.5%) experienced UI. The overall response rate was 86.8%. Functional bladder capacity after treatment was 150 ml, which represented an increase compared with the value (140 ml) before treatment. The voiding frequency per day decreased from 14.0 to 8.5 times. The overall response rate (88.0%) in the non-UI group was not significantly different from that seen in the UI group (83.3%; p>0.05). In non-UI children, the cumulative response rates were 36.0%, 54.0%, 68.0%, 74.0%, 76.0%, and 78.0% at 4, 8, 12, 16, 20, and 24 weeks, respectively. The cumulative response rates in the UI children were 11.1%, 33.3%, 44.4%, 50.0%, 50.0%, and 55.6%, respectively during the same respective time periods. Adverse effects were identified in only two (2.9%) patients, and neither case was severe.
  
  
  CONCLUSIONS
  Propiverine is effective and well tolerated as a treatment for children suffering from OAB with or without UI.
authors.affiliation: Department of Urology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: Woo Jung
authors.initials: WJ
authors.lastname: Kim
authors.forename: Dong-Gi
authors.initials: DG
authors.lastname: Lee
authors.forename: Sang Wook
authors.initials: SW
authors.lastname: Lee
authors.forename: Yoon Kyung
authors.initials: YK
authors.lastname: Lee
authors.forename: Jae Seung
authors.initials: JS
authors.lastname: Lee
authors.forename: Kwan Hyun
authors.initials: KH
authors.lastname: Park
authors.forename: Minki
authors.initials: M
authors.lastname: Baek