title: Dysplasia and colorectal cancer in a patient with ulcerative colitis and primary sclerosing cholangitis: a case report and a short review of the literature.
abstract: Primary sclerosing cholangitis is a chronic progressive disorder which involves the medium size and large ducts in the intrahepatic and extrahepatic biliary tree. The great majority of cases have underlying inflammatory bowel disease, mainly ulcerative colitis. A higher risk of colorectal cancer has been described among ulcerative colitis patients with primary sclerosing cholangitis. Here we report a case of a primary sclerosing cholangitis in a young male with a newly diagnosed ulcerative colitis presenting with colonic dysplasia. Surveillance for colorectal cancer should be strongly recommended in this group of patients.
authors.affiliation: Department of Gastroenterology, Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Madrid, Spain. mariachs2005@gmail.com
authors.forename: María
authors.initials: M
authors.lastname: Chaparro
authors.forename: María
authors.initials: M
authors.lastname: Trapero-Marugán
authors.forename: Mercedes
authors.initials: M
authors.lastname: Guijarro
authors.forename: Consuelo
authors.initials: C
authors.lastname: López
authors.forename: Ricardo
authors.initials: R
authors.lastname: Moreno-Otero
authors.forename: Javier P
authors.initials: JP
authors.lastname: Gisbert
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D001379:Azathioprine / Q000627:therapeutic use; D015209:Cholangitis, Sclerosing / Q000150:complications* / Q000188:drug therapy; D003082:Colectomy; D003093:Colitis, Ulcerative / Q000150:complications* / Q000188:drug therapy; D003106:Colon / Q000473:pathology* / Q000601:surgery; D015179:Colorectal Neoplasms / Q000517:prevention & control*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D000069285:Infliximab; D008297:Male
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000911:Antibodies, Monoclonal; D007166:Immunosuppressive Agents; D000069285:Infliximab; D001379:Azathioprine