title: Trigoflavidols A-C, degraded diterpenoids with antimicrobial activity, from Trigonostemon flavidus.
abstract: Trigoflavidols A (1) and B (2), tetranorditerpenoid dimers possessing a rearrangement skeleton with a spiroketal core moiety, and trigoflavidol C (3), a hexanorditerpenoid, have been isolated from Trigonostemon flavidus along with two known compounds. Compounds 1 and 2 showed moderate antimicrobial activities (MIC values: 3.12-6.25 μg/mL) against Staphylococcus aureus, 8(#)MRSA, and 82(#)MRSA, and 1, 2, and 5 showed weak activities (IC(50) values: 3.75-28.99 μM) against various human tumor cell lines.
authors.affiliation: State Key Laboratory of Phytochemistry and Plant Resources in West China, People's Republic of China.
authors.forename: Gui-Hua
authors.initials: GH
authors.lastname: Tang
authors.forename: Yu
authors.initials: Y
authors.lastname: Zhang
authors.forename: Yu-Cheng
authors.initials: YC
authors.lastname: Gu
authors.forename: Shi-Fei
authors.initials: SF
authors.lastname: Li
authors.forename: Ying-Tong
authors.initials: YT
authors.lastname: Di
authors.forename: Yue-Hu
authors.initials: YH
authors.lastname: Wang
authors.forename: Cui-Xian
authors.initials: CX
authors.lastname: Yang
authors.forename: Guo-Ying
authors.initials: GY
authors.lastname: Zuo
authors.forename: Shun-Lin
authors.initials: SL
authors.lastname: Li
authors.forename: Hong-Ping
authors.initials: HP
authors.lastname: He
authors.forename: Xiao-Jiang
authors.initials: XJ
authors.lastname: Hao
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019665:Euphorbiaceae / Q000737:chemistry*; D006801:Humans; D055624:Methicillin-Resistant Staphylococcus aureus / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D018547:Plant Stems / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D004224:Diterpenes; D004365:Drugs, Chinese Herbal; C574283:trigoflavidol A; C574284:trigoflavidol B; C574285:trigoflavidol C