title: A case of aseptic abscesses syndrome treated with corticosteroids and TNF-alpha blockade.
abstract: Aseptic abscesses syndrome (AA) is an emerging clinicopathological entity characterized by visceral sterile collections of mature neutrophils that do not respond to antibiotics but regress quickly when treated with corticosteroids. Although most previous case reports of AA have been restricted to Europe, we present here a Japanese woman with AA showing recurrence of splenic abscesses, ileocolitis, pyoderma gangrenosum, and arthritis. Although both steroid therapy and tumor necrosis factor (TNF)-alpha blockade were effective, relapses remained frequent.
authors.affiliation: Department of Internal Medicine, Nagaoka Red Cross Hospital, 2-297-1 Senshu, Nagaoka, Niigata, 940-2085, Japan. itotomo@nagaoka.jrc.or.jp
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Ito
authors.forename: Naoko
authors.initials: N
authors.lastname: Sato
authors.forename: Hajime
authors.initials: H
authors.lastname: Yamazaki
authors.forename: Tadashi
authors.initials: T
authors.lastname: Koike
authors.forename: Iwao
authors.initials: I
authors.lastname: Emura
authors.forename: Takako
authors.initials: T
authors.lastname: Saeki
mesh_terms: D000038:Abscess / Q000188:drug therapy* / Q000473:pathology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D001168:Arthritis / Q000188:drug therapy / Q000473:pathology; D002097:C-Reactive Protein / Q000032:analysis; D003424:Crohn Disease / Q000188:drug therapy / Q000473:pathology; D004359:Drug Therapy, Combination; D000068800:Etanercept; D005260:Female; D005334:Fever / Q000175:diagnosis / Q000188:drug therapy; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D007074:Immunoglobulin G / Q000627:therapeutic use*; D000069285:Infliximab; D017511:Pyoderma Gangrenosum / Q000188:drug therapy / Q000473:pathology; D018124:Receptors, Tumor Necrosis Factor / Q000627:therapeutic use*; D012008:Recurrence; D013156:Splenectomy; D013158:Splenic Diseases / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D013577:Syndrome; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000911:Antibodies, Monoclonal; D005938:Glucocorticoids; D007074:Immunoglobulin G; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein; D000069285:Infliximab; D000068800:Etanercept