title: Cell migration: fibroblasts find a new way to get ahead.
abstract: Fibroblasts migrate on two-dimensional (2D) surfaces by forming lamellipodia-actin-rich extensions at the leading edge of the cell that have been well characterized. In this issue, Petrie et al. (2012. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201201124) show that in some 3D environments, including tissue explants, fibroblasts project different structures, termed lobopodia, at the leading edge. Lobopodia still assemble focal adhesions; however, similar to membrane blebs, they are driven by actomyosin contraction and do not accumulate active Rac, Cdc42, and phosphatidylinositol 3-kinases.
authors.affiliation: Institute of Science and Technology Austria, Klosterneuburg, Austria. sixt@ist.ac.at
authors.forename: Michael
authors.initials: M
authors.lastname: Sixt
mesh_terms: D000818:Animals; D002450:Cell Communication; D002465:Cell Movement / Q000502:physiology*; D005347:Fibroblasts / Q000166:cytology / Q000378:metabolism*; D006801:Humans; D011554:Pseudopodia / Q000502:physiology*