title: The role of inflammasome modulation in virulence.
abstract: Pathogens frequently exist in an immunological balancing act with their host. Pathogens must not only replicate within a host but also transmit effectively between hosts to perpetuate their species. On the other hand, the host seeks to maintain homeostasis by clearing pathogens. The inflammasome is a multi-protein complex that can induce cell death and processes IL-1β and additional proinflammatory substrates. In this review we discuss the pathogen specific modulation of inflammasome activation and the role this plays in virulence and disease pathology.
authors.affiliation: Department of Immunology, St. Jude Children's Research Hospital, Memphis, TN, USA.
authors.forename: Christopher R
authors.initials: CR
authors.lastname: Lupfer
authors.forename: Thirumala-Devi
authors.initials: TD
authors.lastname: Kanneganti
mesh_terms: D001419:Bacteria / Q000472:pathogenicity; D001424:Bacterial Infections / Q000276:immunology* / Q000382:microbiology / Q000473:pathology*; D054884:Host-Pathogen Interactions; D006801:Humans; D058847:Inflammasomes / Q000276:immunology* / Q000378:metabolism*; D008954:Models, Biological; D014774:Virulence; D014777:Virus Diseases / Q000276:immunology* / Q000473:pathology* / Q000821:virology; D014780:Viruses / Q000472:pathogenicity
chemical_list: D058847:Inflammasomes