title: Domino cyclization-alkylation protocol for the synthesis of 2,3-functionalized indoles from o-alkynylanilines and allylic alcohols.
abstract: A practical and efficient protocol for the one-pot synthesis of 2,3-substituted indoles was developed via a palladacycle catalyzed domino cyclization-alkylation reaction involving 2-alkynylanilines and allylic alcohols under mild conditions without any additives.
authors.affiliation: Division of Chemistry & Biological Chemistry, School of Physical and Mathematical Sciences, Nanyang Technological University, Singapore, Singapore.
authors.forename: Chang
authors.initials: C
authors.lastname: Xu
authors.forename: Vinod K
authors.initials: VK
authors.lastname: Murugan
authors.forename: Sumod A
authors.initials: SA
authors.lastname: Pullarkat
mesh_terms: D000478:Alkylation; D000814:Aniline Compounds / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D007211:Indoles / Q000138:chemical synthesis*; D015394:Molecular Structure; D020005:Propanols / Q000737:chemistry*
chemical_list: D000814:Aniline Compounds; D007211:Indoles; D020005:Propanols; C006463:allyl alcohol; C023650:aniline