title: [Human papillomavirus infection and cervical intraepithelial neoplasia in dialyzed patients].
abstract: Human papillomavirus (HPV) infection is a risk factor for the development of cervical intraepithelial neoplasia (CIN). The incidence of certain cancers such as HPV-associated CIN is higher among dialysis patients than in the general population. In the literature there are few studies on the prevalence of HPV infection among dialyzed women and almost all of these studies concerned women with positive Pap smears. We enrolled 73 hemodialyzed women attending our center from January 2009 to December 2010; 29 denied informed consent and 44 underwent Pap tests and cervical curettage for HPV (mean age 62 ± 15 years). We found HPV positivity in 6 women (prevalence 13.6%). The prevalence of CIN in our sample was also 13.6% (6/44), 83.3% of which HPV related. Since cervical curettage for HPV is a cheap and easy to perform test with high specificity and sensitivity, we believe it is worthwhile including it in the pre-transplant workup of such women to lower the incidence of CIN in dialyzed patients and transplant recipients.
authors.affiliation: S.C.O. Nefrologia e Dialisi Azienda Ospedaliero-Universitaria Maggiore della Carità, Novara, Italy. paola.david@maggioreosp.novara.it
authors.forename: Paola
authors.initials: P
authors.lastname: David
authors.forename: Elisabetta
authors.initials: E
authors.lastname: Tarrano
authors.forename: Andreana
authors.initials: A
authors.lastname: De Mauri
authors.forename: Carlo
authors.initials: C
authors.lastname: Navino
authors.forename: Maddalena
authors.initials: M
authors.lastname: Brustia
authors.forename: Doriana
authors.initials: D
authors.lastname: Chiarinotti
authors.forename: Roberto
authors.initials: R
authors.lastname: Gherzi
authors.forename: Martino
authors.initials: M
authors.lastname: De Leo
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008875:Middle Aged; D030361:Papillomavirus Infections / Q000453:epidemiology*; D015995:Prevalence; D006435:Renal Dialysis; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology* / Q000821:virology*; D055815:Young Adult; D002578:Uterine Cervical Dysplasia / Q000453:epidemiology* / Q000821:virology*