title: Cancer risks for relatives of patients with serrated polyposis.
abstract: OBJECTIVE
  Serrated polyposis (hyperplastic polyposis) is characterized by multiple polyps with serrated architecture in the colorectum. Although patients with serrated polyposis are known to be at increased risk of colorectal cancer (CRC) and possibly extracolonic cancers, cancer risk for their relatives has not been widely explored. The aim of this study was to estimate the risks of CRC and extracolonic cancers for relatives of patients with serrated polyposis.
  
  
  METHODS
  A cohort of the 1,639 first- and second-degree relatives of 100 index patients with serrated polyposis recruited regardless of a family history of polyps or cancer from genetic clinics in Australia, New Zealand, Canada, and the USA, were retrospectively analyzed to estimate the country-, age-, and sex-specific standardized incidence ratios (SIRs) for relatives compared with the general population.
  
  
  RESULTS
  A total of 102 CRCs were observed in first- and second-relatives (SIR 2.25, 95% confidence interval (CI) 1.75-2.93; P<0.001), with 54 in first-degree relatives (SIR 5.16, 95% CI 3.70-7.30; P<0.001) and 48 in second-degree relatives (SIR 1.38, 95% CI 1.01-1.91; P=0.04). Six pancreatic cancers were observed in first-degree relatives (SIR 3.64, 95% CI 1.70-9.21; P=0.003). There was no statistical evidence of increased risk for cancer of the stomach, brain, breast, or prostate.
  
  
  CONCLUSIONS
  Our finding that relatives of serrated polyposis patients are at significantly increased risk of colorectal and pancreatic cancer adds to the accumulating evidence that serrated polyposis has an inherited component.
authors.affiliation: Centre for MEGA Epidemiology, School of Population Health, University of Melbourne, Carlton, Victoria, Australia.
authors.forename: Aung Ko
authors.initials: AK
authors.lastname: Win
authors.forename: Rhiannon J
authors.initials: RJ
authors.lastname: Walters
authors.forename: Daniel D
authors.initials: DD
authors.lastname: Buchanan
authors.forename: Mark A
authors.initials: MA
authors.lastname: Jenkins
authors.forename: Kevin
authors.initials: K
authors.lastname: Sweet
authors.forename: Wendy L
authors.initials: WL
authors.lastname: Frankel
authors.forename: Albert
authors.initials: A
authors.lastname: de la Chapelle
authors.forename: Diane M
authors.initials: DM
authors.lastname: McKeone
authors.forename: Michael D
authors.initials: MD
authors.lastname: Walsh
authors.forename: Mark
authors.initials: M
authors.lastname: Clendenning
authors.forename: Sally-Ann
authors.initials: SA
authors.lastname: Pearson
authors.forename: Erika
authors.initials: E
authors.lastname: Pavluk
authors.forename: Belinda
authors.initials: B
authors.lastname: Nagler
authors.forename: John L
authors.initials: JL
authors.lastname: Hopper
authors.forename: Michael R
authors.initials: MR
authors.lastname: Gattas
authors.forename: Jack
authors.initials: J
authors.lastname: Goldblatt
authors.forename: Jill
authors.initials: J
authors.lastname: George
authors.forename: Graeme K
authors.initials: GK
authors.lastname: Suthers
authors.forename: Kerry D
authors.initials: KD
authors.lastname: Phillips
authors.forename: Sonja
authors.initials: S
authors.lastname: Woodall
authors.forename: Julie
authors.initials: J
authors.lastname: Arnold
authors.forename: Kathy
authors.initials: K
authors.lastname: Tucker
authors.forename: Michael
authors.initials: M
authors.lastname: Field
authors.forename: Sian
authors.initials: S
authors.lastname: Greening
authors.forename: Steve
authors.initials: S
authors.lastname: Gallinger
authors.forename: Melyssa
authors.initials: M
authors.lastname: Aronson
authors.forename: Renee
authors.initials: R
authors.lastname: Perrier
authors.forename: Michael O
authors.initials: MO
authors.lastname: Woods
authors.forename: Jane S
authors.initials: JS
authors.lastname: Green
authors.forename: Neal
authors.initials: N
authors.lastname: Walker
authors.forename: Christophe
authors.initials: C
authors.lastname: Rosty
authors.forename: Susan
authors.initials: S
authors.lastname: Parry
authors.forename: Joanne P
authors.initials: JP
authors.lastname: Young
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics; D000236:Adenoma / Q000235:genetics; D003111:Colonic Polyps / Q000235:genetics* / Q000473:pathology; D015179:Colorectal Neoplasms / Q000235:genetics; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000235:genetics*; D010190:Pancreatic Neoplasms / Q000235:genetics; D012306:Risk