title: The risk of biopsy-detectable prostate cancer using the prostate cancer prevention Trial Risk Calculator in a community setting.
abstract: METHODS
  Risks of prostate cancer (CaP) and high-grade CaP were evaluated using the Prostate Cancer Prevention Trial Risk Calculator (PCPTRC) in an age-stratified random sample of 1,021 Caucasian and African-American men with no previous diagnosis of CaP, aged 55-74 years, residing in King County, WA, USA.
  
  
  RESULTS
  Median PCPTRC risks of CaP (high-grade CaP) were 15.6% (1.2%), 18.7% (2.0%), 18.5% (2.2%), and 26.4% (5.1%) for 55-59, 60-64, 65-69, and 70-74-year-old men, respectively; 25.2% of men aged 55-59 had a 25% or greater PCPTRC risk of CaP; this increased to 53.1% in men aged 70-74; 9.4% of men aged 55-59 had a 6% or greater PCPTRC risk of high-grade CaP, increasing to 44.1% in men aged 70-74.
  
  
  CONCLUSIONS
  PCPTRC risk of CaP in a community of US males is high and confounded with overdetected cancers. In contrast, average community PCPTRC risk of high-grade disease is low and increases gradually by age and may better serve for counseling purposes.
authors.affiliation: Department of Urology, University of Texas Health Science Center at San Antonio (UTHSCSA), San Antonio, TX 78229, USA; Department of Epidemiology, Biostatistics, UTHSCSA, San Antonio, TX 78229, USA; School of Public Health, University of Texas Health Science Center at Houston, Houston, TX 77025, USA; Cancer Therapy and Research Center, UTHSCSA, San Antonio, TX 78229, USA. Electronic address: liangy@uthscsa.edu.
authors.forename: Yuanyuan
authors.initials: Y
authors.lastname: Liang
authors.forename: Donna P
authors.initials: DP
authors.lastname: Ankerst
authors.forename: Ziding
authors.initials: Z
authors.lastname: Feng
authors.forename: Rong
authors.initials: R
authors.lastname: Fu
authors.forename: Janet L
authors.initials: JL
authors.lastname: Stanford
authors.forename: Ian M
authors.initials: IM
authors.lastname: Thompson
mesh_terms: D001741:Black or African American / Q000706:statistics & numerical data; D000368:Aged; D001706:Biopsy; D016022:Case-Control Studies; D003153:Community Health Services / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000517:prevention & control*; D018570:Risk Assessment / Q000706:statistics & numerical data; D012307:Risk Factors; D044465:White People / Q000706:statistics & numerical data