title: [Coumarin-induced necrotic purpura of the skin -- case report and review of the literature].
abstract: We report the case of a 28-year old woman with extensive red-black colored lesions of the skin on the left thigh, which appeared without trauma. The disease arrived during longterm coumarin therapy because of a deep vein thrombosis and an antiphospholipid syndrome. After consideration of the differential diagnoses and due to the typical clinical picture we made the diagnosis of coumarin necrosis. We review the clinical and therapeutic features for this rare complication.
authors.affiliation: Universitätsklinik für Allgemeine Innere Medizin, Inselspital Bern. Simon.Meierhofer@spitalnetzbern.ch
authors.forename: S
authors.initials: S
authors.lastname: Meierhofer
authors.forename: G
authors.initials: G
authors.lastname: Colucci
authors.forename: S
authors.initials: S
authors.lastname: Steiner
mesh_terms: D000328:Adult; D000925:Anticoagulants / Q000009:adverse effects* / Q000627:therapeutic use; D016736:Antiphospholipid Syndrome / Q000188:drug therapy*; D001780:Blood Coagulation Tests; D003374:Coumarins / Q000009:adverse effects* / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004334:Drug Administration Schedule; D003875:Drug Eruptions / Q000175:diagnosis* / Q000473:pathology; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007868:Leg Dermatoses / Q000139:chemically induced* / Q000473:pathology; D008134:Long-Term Care; D009336:Necrosis; D010644:Phenprocoumon / Q000009:adverse effects* / Q000627:therapeutic use; D012867:Skin / Q000473:pathology; D020246:Venous Thrombosis / Q000188:drug therapy*; D014813:Vitamin K Deficiency / Q000139:chemically induced / Q000188:drug therapy
chemical_list: D000925:Anticoagulants; D003374:Coumarins; C030123:coumarin; D010644:Phenprocoumon