title: Predictive value of adenosine 5'-monophosphate challenge in preschool children for the diagnosis of asthma 5 years later.
abstract: We evaluated the predictive values of preschool bronchial challenge with nebulized adenosine 5'-monophosphate (AMP) using the auscultation method for having asthma 5 years later. Preschool AMP challenge had a high negative (90%) and a moderate positive (67%) predictive value for asthma 5 years later. Positive predictive value increased with the age at which the challenge was performed. The degree of preschool response to AMP was associated with the severity of asthma at school age.
authors.affiliation: Institute of Pulmonology, Hadassah University Medical Center, Jerusalem, Israel.
authors.forename: Shlomo
authors.initials: S
authors.lastname: Cohen
authors.forename: Avraham
authors.initials: A
authors.lastname: Avital
authors.forename: Avigdor
authors.initials: A
authors.lastname: Hevroni
authors.forename: Alina
authors.initials: A
authors.lastname: Avenshtein
authors.forename: Ronen
authors.initials: R
authors.lastname: Hadi
authors.forename: Chaim
authors.initials: C
authors.lastname: Springer
mesh_terms: D000249:Adenosine Monophosphate; D001249:Asthma / Q000175:diagnosis*; D001985:Bronchial Provocation Tests; D002648:Child; D002675:Child, Preschool; D006801:Humans; D011237:Predictive Value of Tests; D013997:Time Factors
chemical_list: D000249:Adenosine Monophosphate