title: In vivo NIRF imaging of tumor targetability of nanosized liposomes in tumor-bearing mice.
abstract: To optimize tumor targetability of nanosized liposomes for application as drug carriers, various liposomes are prepared by incorporating different amounts (10, 30, and 50 wt%) of cationic, anionic, and PEGylated lipids into neutral lipid. In vivo near-infrared fluorescence images reveal that PEG-PE/PC liposomes display high tumor accumulation in tumor-bearing mice, while large amounts of DOTAP/PC liposomes are rapidly captured in the liver, resulting in poor tumor accumulation. These results demonstrate that optimization of the surface properties of liposomes is very important for their tumor targetability, and that in vivo imaging techniques are useful in developing and optimizing nanosized liposome-based drug carriers.
authors.affiliation: Department of Life and Nanopharmaceutical Science, Kyung Hee University, 1 Hoegi-dong, Dongdaemun-gu, Seoul 130-701, Republic of Korea.
authors.forename: Sangmin
authors.initials: S
authors.lastname: Lee
authors.forename: Seung-Young
authors.initials: SY
authors.lastname: Lee
authors.forename: Sangjin
authors.initials: S
authors.lastname: Park
authors.forename: Ju Hee
authors.initials: JH
authors.lastname: Ryu
authors.forename: Jin Hee
authors.initials: JH
authors.lastname: Na
authors.forename: Heebeom
authors.initials: H
authors.lastname: Koo
authors.forename: Kyung Eun
authors.initials: KE
authors.lastname: Lee
authors.forename: Hyesung
authors.initials: H
authors.lastname: Jeon
authors.forename: Ick Chan
authors.initials: IC
authors.lastname: Kwon
authors.forename: Kwangmeyung
authors.initials: K
authors.lastname: Kim
authors.forename: Seo Young
authors.initials: SY
authors.lastname: Jeong
mesh_terms: D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods*; D005229:Fatty Acids, Monounsaturated / Q000737:chemistry* / Q000494:pharmacology*; D005453:Fluorescence; D006367:HeLa Cells; D006801:Humans; D008081:Liposomes; D008297:Male; D051379:Mice; D008819:Mice, Nude; D008856:Microscopy, Fluorescence / Q000379:methods; D053758:Nanoparticles / Q000737:chemistry*; D009374:Neoplasms, Experimental / Q000473:pathology* / Q000648:ultrastructure; D000644:Quaternary Ammonium Compounds / Q000737:chemistry* / Q000494:pharmacology*; D013499:Surface Properties
chemical_list: D005229:Fatty Acids, Monounsaturated; D008081:Liposomes; D000644:Quaternary Ammonium Compounds; C070046:1,2-dioleoyloxy-3-(trimethylammonium)propane