title: Expression and prognostic significance of CIP2A mRNA in hepatocellular carcinoma and nontumoral liver tissues.
abstract: OBJECTIVE
  This study was undertaken to determine the role of cancerous inhibitor of protein phosphatase 2A (CIP2A) in predicting prognosis of hepatocellular carcinoma (HCC).
  
  
  METHODS
  CIP2A mRNA level of 136 pairs of tumor and nontumoral liver tissues of HCC patients after hepatectomy were investigated by quantitative real-time reverse transcription polymerase chain reaction.
  
  
  RESULTS
  Intratumoral CIP2A mRNA was not associated with patients' prognosis. However, nontumoral CIP2A mRNA, which was correlated with lack of tumor encapsulation, poor tumor differentiation, intrahepatic metastasis, and high tumor-node-metastasis stage was an independent risk factor for overall survival and recurrence-free survival.
  
  
  CONCLUSIONS
  Nontumoral CIP2A mRNA expression might serve as a novel biomarker for HCC patients undergoing resection.
authors.affiliation: State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, China.
authors.forename: Pinzhu
authors.initials: P
authors.lastname: Huang
authors.forename: Jiliang
authors.initials: J
authors.lastname: Qiu
authors.forename: Jinghong
authors.initials: J
authors.lastname: You
authors.forename: Jian
authors.initials: J
authors.lastname: Hong
authors.forename: Binkui
authors.initials: B
authors.lastname: Li
authors.forename: Kai
authors.initials: K
authors.lastname: Zhou
authors.forename: Guihua
authors.initials: G
authors.lastname: Chen
authors.forename: Yunfei
authors.initials: Y
authors.lastname: Yuan
authors.forename: Ruhai
authors.initials: R
authors.lastname: Zou
mesh_terms: D001324:Autoantigens / Q000235:genetics*; D014408:Biomarkers, Tumor / Q000235:genetics; D006528:Carcinoma, Hepatocellular / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D002460:Cell Line; D045744:Cell Line, Tumor; D005260:Female; D020869:Gene Expression Profiling; D015972:Gene Expression Regulation, Neoplastic; D006498:Hepatectomy / Q000379:methods; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D053208:Kaplan-Meier Estimate; D008099:Liver / Q000166:cytology / Q000378:metabolism*; D008113:Liver Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D008297:Male; D008565:Membrane Proteins / Q000235:genetics*; D008875:Middle Aged; D011379:Prognosis; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D001324:Autoantigens; D014408:Biomarkers, Tumor; C500266:CIP2A protein, human; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D012333:RNA, Messenger