title: SIGIRR, a negative regulator of colon tumorigenesis.
abstract: Inappropriate activation of the Toll-IL-1R (TL-IL-1) signaling by commensal bacteria contributes to the pathogenesis of inflammatory bowel diseases and colitis-associated cancer. Recent studies have identified SIGIRR as a negative regulator of TL-IL-1 signaling. It dampens intestinal inflammation and tumorigenesis in the colon. In this review, we will discuss the role of SIGIRR in different cell types and the mechanisms underlying its tumor suppressor function.
authors.affiliation: Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA.
authors.forename: Junjie
authors.initials: J
authors.lastname: Zhao
authors.forename: Jarod
authors.initials: J
authors.lastname: Zepp
authors.forename: Katarzyna
authors.initials: K
authors.lastname: Bulek
authors.forename: Xiaoxia
authors.initials: X
authors.lastname: Li