title: Lack of evidence for integration of Trypanosoma cruzi minicircle DNA in South American human genomes.
abstract: Horizontal gene transfer involving kinetoplast DNA minicircles between Trypanosoma cruzi and its mammalian hosts has recently been proposed as a usual consequence of infection (Hecht et al., 2010). However, we have found no sequences longer than 29 bp perfectly matching minicircles of T. cruzi in the unassembled reads from Colombian and Peruvian human populations provided by the 1,000 Genome project (129 individuals in total, coverage from 1.4× to 36.3×, read length from 42 to 101 bp). The weak sequence matches that were identified are shared with a Finnish population used as a control from a non-endemic area.
authors.affiliation: Institute of Parasitology, Biology Centre, Czech Academy of Sciences, 37005 České Budějovice (Budweis), Czech Republic.
authors.forename: Olga
authors.initials: O
authors.lastname: Flegontova
authors.forename: Julius
authors.initials: J
authors.lastname: Lukeš
authors.forename: Pavel
authors.initials: P
authors.lastname: Flegontov
mesh_terms: D003105:Colombia; D018105:DNA, Kinetoplast / Q000235:genetics*; D015894:Genome, Human; D006801:Humans; D010568:Peru; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid; D014349:Trypanosoma cruzi / Q000235:genetics*
chemical_list: D018105:DNA, Kinetoplast