title: Unique MRI findings as an early predictor of osteonecrosis in pediatric acute lymphoblastic leukemia.
abstract: OBJECTIVE
  Osteonecrosis is a potential complication of glucocorticoid chemotherapy in children surviving leukemia. Early diagnosis may allow effective interventions to minimize or ameliorate joint deterioration and obviate surgical intervention. We investigated the significance of MRI signal changes that precede the currently recognized "double-line" changes, which are considered pathognomic of osteonecrosis.
  
  
  METHODS
  We retrospectively reviewed MRI scans acquired during prospective screening and follow-up of pediatric patients with leukemia for osteonecrosis.
  
  
  RESULTS
  Of 481 patients, we identified 21 cases (4.3%; 12 boys; median age at leukemia diagnosis, 12.8 years) with subtle poorly defined geographically delineated MRI signal abnormalities in knees or hips, or both, that progressed over a median of 4 months (range, 1.6-18.5 months) to florid MRI signs of osteonecrosis. Articular surface collapse developed in three hips (two patients) and three knees (three patients). Three patients subsequently underwent surgical intervention (one bilateral total hip arthroplasty and one bilateral and one unilateral hip core decompression). The median duration of follow-up was 27 months (range, 1.9-90.7 months).
  
  
  CONCLUSIONS
  The MRI signal abnormalities described here appear to herald extensive osteonecrosis and precede the typical MRI findings of osteonecrosis previously reported in the literature.
authors.affiliation: Department of Radiology, LeBonheur Children's Medical Center, Memphis, TN, USA.
authors.forename: Rakhee Kisan
authors.initials: RK
authors.lastname: Sansgiri
authors.forename: Michael D
authors.initials: MD
authors.lastname: Neel
authors.forename: Manuel
authors.initials: M
authors.lastname: Soto-Fourier
authors.forename: Sue C
authors.initials: SC
authors.lastname: Kaste
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000009:adverse effects*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002648:Child; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D010020:Osteonecrosis / Q000139:chemically induced* / Q000175:diagnosis* / Q000601:surgery; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D011237:Predictive Value of Tests; D012189:Retrospective Studies
chemical_list: D000305:Adrenal Cortex Hormones; D000970:Antineoplastic Agents