title: Is psoriatic arthritis a result of abnormalities in acquired or innate immunity?
abstract: Psoriatic arthritis is a common chronic inflammatory joint disease in which both inflammation and tissue damage contribute to the patient's outcome. Abnormal activation of the innate and the adaptive immune system contributes to the chronic disease process. Novel insights into these immune pathways are further corroborated by genetic evidence. In this review, we compare the current paradigm of psoriasis to mechanisms that likely play a role in psoriatic arthritis and provide an overview of the role of immune mechanisms in the different features of the disease.
authors.affiliation: Laboratory for Skeletal Development and Joint Disorders, Department of Development and Regeneration, KU Leuven, Herestraat 49, 300 Leuven, Belgium. rik.lories@uz.kuleuven.be
authors.forename: Rik J
authors.initials: RJ
authors.lastname: Lories
authors.forename: Kurt
authors.initials: K
authors.lastname: de Vlam
mesh_terms: D056704:Adaptive Immunity; D015535:Arthritis, Psoriatic / Q000235:genetics / Q000276:immunology* / Q000503:physiopathology; D016723:Bone Remodeling / Q000502:physiology; D020022:Genetic Predisposition to Disease; D006801:Humans; D007113:Immunity, Innate; D010012:Osteogenesis / Q000502:physiology; D011565:Psoriasis / Q000276:immunology