title: Magnetic source imaging in non-lesional neocortical epilepsy: additional value and comparison with ICEEG.
abstract: OBJECTIVE
  To investigate the utility of magnetic source imaging (MSI) for localizing the epileptogenic zone (EZ) and predicting epilepsy surgery outcome in non-lesional neocortical focal epilepsy (NLNE) patients.
  
  
  METHODS
  Data from 18 consecutive patients with NLNE who underwent presurgical evaluation including intracranial electroencephalography (ICEEG) and MSI were studied. Follow-up after epilepsy surgery was ≥24 months. Intracranial electroencephalography and MSI results were classified using a sublobar classification.
  
  
  RESULTS
  Sublobar ICEEG focus was completely resected in 15 patients; seizure-free rate was 60%. Eight patients showed sublobar-concordant ICEEG/MSI results and complete resection of both regions; seizure-free rate was 87.5%. Seizure-free rate in cases not matching these criteria was only 30% (p=0.013).
  
  
  CONCLUSIONS
  Magnetoencephalography is a useful tool to localize the EZ and determine the site of surgical resection in NLNE patients. When sublobar concordance with ICEEG is observed, MSI increases the predictive value for a seizure-free epilepsy surgery outcome in these patients.
authors.affiliation: Cleveland Clinic Epilepsy Center, Neurological Institute, 9500 Euclid Avenue, Desk S-51, Cleveland, OH 44195, USA. felix.schneider@uni-greifswald.de
authors.forename: Felix
authors.initials: F
authors.lastname: Schneider
authors.forename: Andreas V
authors.initials: AV
authors.lastname: Alexopoulos
authors.forename: Zhong
authors.initials: Z
authors.lastname: Wang
authors.forename: Salah
authors.initials: S
authors.lastname: Almubarak
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Kakisaka
authors.forename: Kazutaka
authors.initials: K
authors.lastname: Jin
authors.forename: Dileep
authors.initials: D
authors.lastname: Nair
authors.forename: John C
authors.initials: JC
authors.lastname: Mosher
authors.forename: Imad M
authors.initials: IM
authors.lastname: Najm
authors.forename: Richard C
authors.initials: RC
authors.lastname: Burgess
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D015331:Cohort Studies; D004569:Electroencephalography / Q000379:methods*; D004828:Epilepsies, Partial / Q000503:physiopathology* / Q000601:surgery; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D015225:Magnetoencephalography / Q000379:methods*; D008297:Male; D008875:Middle Aged; D019579:Neocortex / Q000503:physiopathology* / Q000601:surgery; D059906:Neuroimaging / Q000379:methods*; D019635:Neurosurgical Procedures; D011237:Predictive Value of Tests; D016896:Treatment Outcome; D055815:Young Adult