title: Solid-phase synthesis of tetrasubstituted pyrrolo[2,3-d]pyrimidines.
abstract: A facile solid phase synthesis of 2,4,6,7-tetrasubstituted pyrrolo[2,3-d]pyrimidines is described. The synthesis involves a highly efficient five-step route starting from resin-bound dimeric peptoids. To demonstrate the versatility of our method, a representative library of 108 tetrasubstituted pyrrolo[2,3-d]pyrimidines of high quality was synthesized.
authors.affiliation: Department of Biochemistry and Molecular Biology, and Indiana University Simon Cancer Centre, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA.
authors.forename: Ji Hoon
authors.initials: JH
authors.lastname: Lee
authors.forename: Hyun-Suk
authors.initials: HS
authors.lastname: Lim
mesh_terms: D020650:Combinatorial Chemistry Techniques; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D034444:Peptoids / Q000737:chemistry; D011743:Pyrimidines / Q000138:chemical synthesis*; D011758:Pyrroles / Q000138:chemical synthesis*; D054852:Small Molecule Libraries; D060327:Solid-Phase Synthesis Techniques
chemical_list: D034444:Peptoids; D011743:Pyrimidines; D011758:Pyrroles; C450639:Pyrrolo(2,3-d)pyrimidine; D054852:Small Molecule Libraries