title: Bio-inspired synthesis and biological evaluation of a colchicine-related compound library.
abstract: A bio-inspired investigation of the reactions of substrates of type 1 with VOF(3) and PIFA [phenyliodine(III) bis(trifluoroacetate)] led to a collection of colchicine-like compounds 2-5 and related systems. Biological evaluation revealed that some of the synthesized products had significant cytotoxic properties against the colon cancer cell line HT-29.
authors.affiliation: Department of Chemistry, The Scripps Research Institute, La Jolla, CA 92037, USA. kcn@scripps.edu
authors.forename: K C
authors.initials: KC
authors.lastname: Nicolaou
authors.forename: Roman A
authors.initials: RA
authors.lastname: Valiulin
authors.forename: Jonathan K
authors.initials: JK
authors.lastname: Pokorski
authors.forename: Vicki
authors.initials: V
authors.lastname: Chang
authors.forename: Jason S
authors.initials: JS
authors.lastname: Chen
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D017209:Apoptosis / Q000187:drug effects; D003078:Colchicine / Q000737:chemistry*; D019073:HT29 Cells; D006801:Humans; D054852:Small Molecule Libraries / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity
chemical_list: D000970:Antineoplastic Agents; D054852:Small Molecule Libraries; D003078:Colchicine