title: Lack of association between CLEC5A gene single-nucleotide polymorphisms and Kawasaki disease in Taiwanese children.
abstract: BACKGROUND
  Kawasaki disease is characterized by systemic vasculitis of unknown etiology. Previous genetic studies have identified certain candidate genes associated with susceptibility to KD and coronary artery lesions. Host innate immune response factors are involved in modulating the disease outcome. The aim of this study was to investigate CLEC5A (C-type lectin domain family 5) genetic polymorphisms with regards to the susceptibility and outcome of KD.
  
  
  METHODS
  A total of 1045 subjects (381 KD patients and 664 controls) were enrolled to identify 4 tagging single-nucleotide polymorphisms (tSNPs) of CLEC5A (rs1285968, rs11770855, rs1285935, rs1285933) by using the TaqMan Allelic Discrimination Assay. The Hardy-Weinberg equilibrium was assessed in cases and controls, and genetic effects were evaluated by the chi-square test.
  
  
  RESULTS
  No significant associations were noted between the genotypes and allele frequency of the 4 CLEC5A tSNPs between controls and patients. In the patients, polymorphisms of CLEC5A showed no significant association with coronary artery lesion formation and intravenous immunoglobulin treatment response.
  
  
  CONCLUSIONS
  This study showed for the first time that polymorphisms of CLEC5A are not associated with susceptibility to KD, coronary artery lesion formation, and intravenous immunoglobulin treatment response in a Taiwanese population.
authors.affiliation: Department of Anesthesiology, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 807, Taiwan.
authors.forename: Ya-Ling
authors.initials: YL
authors.lastname: Yang
authors.forename: Wei-Pin
authors.initials: WP
authors.lastname: Chang
authors.forename: Yu-Wen
authors.initials: YW
authors.lastname: Hsu
authors.forename: Wei-Chiao
authors.initials: WC
authors.lastname: Chen
authors.forename: Hong-Ren
authors.initials: HR
authors.lastname: Yu
authors.forename: Chi-Di
authors.initials: CD
authors.lastname: Liang
authors.forename: Yao-Ting
authors.initials: YT
authors.lastname: Tsai
authors.forename: Ying-Hsien
authors.initials: YH
authors.lastname: Huang
authors.forename: Kuender D
authors.initials: KD
authors.lastname: Yang
authors.forename: Ho-Chang
authors.initials: HC
authors.lastname: Kuo
authors.forename: Wei-Chiao
authors.initials: WC
authors.lastname: Chang
mesh_terms: D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006239:Haplotypes; D006801:Humans; D007223:Infant; D037181:Lectins, C-Type / Q000235:genetics*; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011956:Receptors, Cell Surface / Q000235:genetics*; D013624:Taiwan
chemical_list: C509771:CLEC5A protein, human; D037181:Lectins, C-Type; D011956:Receptors, Cell Surface