title: Administrative data algorithms to identify second breast cancer events following early-stage invasive breast cancer.
abstract: BACKGROUND
  Studies of breast cancer outcomes rely on the identification of second breast cancer events (recurrences and second breast primary tumors). Cancer registries often do not capture recurrences, and chart abstraction can be infeasible or expensive. An alternative is using administrative health-care data to identify second breast cancer events; however, these algorithms must be validated against a gold standard.
  
  
  METHODS
  We developed algorithms using data from 3152 women in an integrated health-care system who were diagnosed with stage I or II breast cancer in 1993-2006. Medical record review served as the gold standard for second breast cancer events. Administrative data used in algorithm development included procedures, diagnoses, prescription fills, and cancer registry records. We randomly divided the cohort into training and testing samples and used a classification and regression tree analysis to build algorithms for classifying women as having or not having a second breast cancer event. We created several algorithms for researchers to use based on the relative importance of sensitivity, specificity, and positive predictive value (PPV) in future studies.
  
  
  RESULTS
  The algorithm with high specificity and PPV had 89% sensitivity (95% confidence interval [CI] = 84% to 92%), 99% specificity (95% CI = 98% to 99%), and 90% PPV (95% CI = 86% to 94%); the high-sensitivity algorithm had 96% sensitivity (95% CI = 93% to 98%), 95% specificity (95% CI = 94% to 96%), and 74% PPV (95% CI = 68% to 78%).
  
  
  CONCLUSIONS
  Algorithms based on administrative data can identify second breast cancer events with high sensitivity, specificity, and PPV. The algorithms presented here promote efficient outcomes research, allowing researchers to prioritize sensitivity, specificity, or PPV in identifying second breast cancer events.
authors.affiliation: Group Health Research Institute, 1730 Minor Ave, Ste. 1600, Seattle, WA 98101, USA. chubak.j@ghc.org
authors.forename: Jessica
authors.initials: J
authors.lastname: Chubak
authors.forename: Onchee
authors.initials: O
authors.lastname: Yu
authors.forename: Gaia
authors.initials: G
authors.lastname: Pocobelli
authors.forename: Lois
authors.initials: L
authors.lastname: Lamerato
authors.forename: Joe
authors.initials: J
authors.lastname: Webster
authors.forename: Marianne N
authors.initials: MN
authors.lastname: Prout
authors.forename: Marianne
authors.initials: M
authors.lastname: Ulcickas Yood
authors.forename: William E
authors.initials: WE
authors.lastname: Barlow
authors.forename: Diana S M
authors.initials: DS
authors.lastname: Buist
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D001943:Breast Neoplasms / Q000453:epidemiology / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000453:epidemiology / Q000473:pathology*; D019033:Delivery of Health Care, Integrated; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D016609:Neoplasms, Second Primary / Q000175:diagnosis* / Q000453:epidemiology; D011237:Predictive Value of Tests; D018426:SEER Program; D012680:Sensitivity and Specificity; D014861:Washington / Q000453:epidemiology