title: Synthesis and antiglycation activity of kaempferol-3-O-rutinoside (nicotiflorin).
abstract: Kaempferol-3-O-α-L-rhamanopyranosyl-(1'''-6'')-β-D-glucopyranoside (1) (Nicotiflorin or kaempferol-3-O-rutinoside), isolated from the aerial parts of Osyris wightiana Wall. ex Wight, exhibited a potent antiglycation activity in vitro. A short and efficient route to kaempferol-3-O-rutinoside (1) is also described in this paper. To study the structure-activity relationship, few other derivatives of kaempferol were also evaluated for their antiglycation activity. Moreover the cytotoxicity analysis was also performed for these compounds. The Structure-Activity Relationship (SAR) studies showed that sugar derivatives of kaempferol possess a promising antiglycation activity.
authors.affiliation: H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi-75270, Pakistan.
authors.forename: Sajan
authors.initials: S
authors.lastname: Lal Shyaula
authors.forename: Ghulam
authors.initials: G
authors.lastname: Abbas
authors.forename: Hina
authors.initials: H
authors.lastname: Siddiqui
authors.forename: Samina A
authors.initials: SA
authors.lastname: Sattar
authors.forename: M Iqbal
authors.initials: MI
authors.lastname: Choudhary
authors.forename: Fatima Z
authors.initials: FZ
authors.lastname: Basha
mesh_terms: D000818:Animals; D002417:Cattle; D049109:Cell Proliferation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000187:drug effects*; D005419:Flavonoids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006031:Glycosylation / Q000187:drug effects; D044949:Kaempferols / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D015394:Molecular Structure; D041681:NIH 3T3 Cells; D010636:Phenols / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D012710:Serum Albumin, Bovine / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: D005419:Flavonoids; D044949:Kaempferols; D010636:Phenols; C513882:nicotiflorin; D012710:Serum Albumin, Bovine; C492687:kaempferol-3-O-rutinoside