title: [Daptomycin in Gram-positive bacterial infections in oncohematological patients and transplant recipients].
abstract: Gram-positive infections are a major cause of morbidity and mortality in oncohematological patients and transplant recipients. The most frequently isolated Gram-positive organisms are the coagulase-negative staphylococci, Staphylococcus aureus and Enterococcus spp., and viridans group streptococci. Antibiotic resistance in these organisms is increasing and poses a challenge to clinicians. Daptomycin is rapidly bactericidal against a broad spectrum of gram-positive bacteria, including strains resistant to other drugs. The present article reviews some aspects of Gram-positive infections in these immunocompromised patients and provides a detailed analysis of experience with daptomycin in the treatment of these infections.
authors.affiliation: Servicio de Enfermedades Infecciosas, Hospital Universitari de Bellvitge-IDIBELL, Universitat de Barcelona, L'Hospitalet de Llobregat, Barcelona, España. jcarratala@ub.edu
authors.forename: Jordi
authors.initials: J
authors.lastname: Carratalà
authors.forename: Oscar
authors.initials: O
authors.lastname: Len
authors.forename: Julián
authors.initials: J
authors.lastname: de la Torre-Cisneros
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D017576:Daptomycin / Q000627:therapeutic use*; D016908:Gram-Positive Bacterial Infections / Q000150:complications* / Q000188:drug therapy*; D019337:Hematologic Neoplasms / Q000150:complications*; D006801:Humans; D009503:Neutropenia / Q000150:complications; D016377:Organ Transplantation
chemical_list: D000900:Anti-Bacterial Agents; D017576:Daptomycin