title: Diastereoselective multicomponent synthesis and anti-HSV-1 evaluation of dihydrofuran-fused derivatives.
abstract: Enolizable 6-membered cyclic 1,3-dicarbonyls undergo an efficient and diastereoselective domino condensation/addition/heterocyclization reaction with arylaldehydes and phenacyl chloride, producing highly substituted dihydrofuran-fused derivatives. Ring size of the cyclic 1,3-dicarbonyls and the presence of at least one keto group are crucial to the reaction's success. The new compounds were evaluated in vitro for antiviral activity against herpes simplex virus type-1 (HSV-1). Interestingly, some of them appeared able to interfere with HSV-1 replication, without detection of cytotoxic effects.
authors.affiliation: Dipartimento di Chimica Organica e Biologica, Università di Messina, Messina, Italy.
authors.forename: Angela
authors.initials: A
authors.lastname: Scala
authors.forename: Massimiliano
authors.initials: M
authors.lastname: Cordaro
authors.forename: Francesco
authors.initials: F
authors.lastname: Risitano
authors.forename: Ivana
authors.initials: I
authors.lastname: Colao
authors.forename: Assunta
authors.initials: A
authors.lastname: Venuti
authors.forename: Maria Teresa
authors.initials: MT
authors.lastname: Sciortino
authors.forename: Patrizia
authors.initials: P
authors.lastname: Primerano
authors.forename: Giovanni
authors.initials: G
authors.lastname: Grassi
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D002522:Chlorocebus aethiops; D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018259:Herpesvirus 1, Human / Q000187:drug effects / Q000254:growth & development; D015394:Molecular Structure; D013237:Stereoisomerism; D014709:Vero Cells; D010948:Viral Plaque Assay; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D005663:Furans