title: A new investigation for some steroidal derivatives as anti-Alzheimer agents.
abstract: We herein report the anti-Alzheimer activity of some synthesized heterocyclic pyrimidine and thiopyrimidine derivatives fused with steroidal structure. Twenty-one of these compounds were synthesized and conveniently screened for their anti-Alzheimer activities using of Flurbiprofen as the reference drug. Some of these compounds were demonstrated to exhibit remarkable activity and their β-amyloid (Aβ) lowering results as IC(50) values reported.
authors.affiliation: Research Unit, Saco Pharm. Co., 6th October City 11632, Egypt.
authors.forename: Mohamed M
authors.initials: MM
authors.lastname: Abdalla
authors.forename: Mohamed A
authors.initials: MA
authors.lastname: Al-Omar
authors.forename: Rashad A
authors.initials: RA
authors.lastname: Al-Salahi
authors.forename: Abdel-Galil E
authors.initials: AG
authors.lastname: Amr
authors.forename: Nermien M
authors.initials: NM
authors.lastname: Sabrye
mesh_terms: D000544:Alzheimer Disease / Q000188:drug therapy* / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000378:metabolism; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology; D002460:Cell Line; D016861:Cyclooxygenase Inhibitors / Q000737:chemistry / Q000494:pharmacology; D005260:Female; D006571:Heterocyclic Compounds / Q000737:chemistry / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D011743:Pyrimidines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013256:Steroids / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D016229:Amyloid beta-Peptides; D000893:Anti-Inflammatory Agents; D016861:Cyclooxygenase Inhibitors; D006571:Heterocyclic Compounds; D011743:Pyrimidines; D013256:Steroids