title: Automated drop-on-demand system with real-time gravimetric control for precise dosage formulation.
abstract: Many of the therapies for personalized medicine have few dosage options, and the successful translation of these therapies to the clinic is significantly dependent on the drug/formulation delivery platform. We have developed a lab-scale integrated system for microdosing of drug formulations with high accuracy and precision that is capable of feedback control. The designed modular drug dispensing system includes a microdispensing valve unit and is fully automated with a LabVIEW-controlled computer interface. The designed system is capable of dispensing drug droplets with volumes ranging from nanoliters to microliters with high accuracy (relative standard deviation <1%). We have determined that the system is capable of accurate dosing and in-line real-time gravimetric control.
authors.affiliation: State University of New Jersey, Piscataway, NJ, USA.
authors.forename: A
authors.initials: A
authors.lastname: Sahay
authors.forename: M
authors.initials: M
authors.lastname: Brown
authors.forename: F
authors.initials: F
authors.lastname: Muzzio
authors.forename: Paul
authors.initials: P
authors.lastname: Takhistov
mesh_terms: D001331:Automation; D002626:Chemistry, Pharmaceutical / Q000295:instrumentation* / Q000592:standards; D004304:Dosage Forms; D015203:Reproducibility of Results; D012984:Software
chemical_list: D004304:Dosage Forms