title: Polyneuropathy associated with the diffuse infiltrative lymphocytosis syndrome.
abstract: Diffuse infiltrative lymphocytosis syndrome (DILS) arises in HIV-positive patients secondary to infiltration of lymphocytes into the peripheral tissues and produces the disease's characteristic symptoms-parotid gland enlargement and a sicca syndrome. Many patients, however, first seek medical attention for treatment of the extraglandular manifestations of DILS, most commonly interstitial pneumonitis. In this case report, we describe an atypical presentation of DILS characterized by polyradiculoneuropathy in the absence of parotid gland enlargement or interstitial pneumonitis. Minor salivary gland biopsy of the patient's lip confirmed a chronic inflammatory state with lymphoid aggregates within the minor salivary glands. He was started on prednisone with immediate improvement in his symptoms. This report illustrates for clinicians the diverse extraglandular manifestations of DILS and underscores the importance of considering it in the differential diagnosis of HIV-positive patients with a preserved CD4 count who present with peripheral neuropathy.
authors.affiliation: 1University of Michigan Medical School, Ann Arbor, MI, USA.
authors.forename: Jessica R
authors.initials: JR
authors.lastname: Golbus
authors.forename: Gary
authors.initials: G
authors.lastname: Gallagher
authors.forename: Gerald
authors.initials: G
authors.lastname: Blackburn
authors.forename: Sandro
authors.initials: S
authors.lastname: Cinti
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D004487:Edema / Q000175:diagnosis* / Q000188:drug therapy; D005145:Face; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D008218:Lymphocytosis / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D011129:Polyradiculoneuropathy / Q000175:diagnosis* / Q000188:drug therapy; D011241:Prednisone / Q000627:therapeutic use; D013577:Syndrome; D014987:Xerostomia / Q000175:diagnosis / Q000188:drug therapy
chemical_list: D000893:Anti-Inflammatory Agents; D011241:Prednisone