title: Low bone mineral density is associated with the onset of spontaneous osteonecrosis of the knee.
abstract: OBJECTIVE
  The primary event preceding the onset of symptoms in spontaneous osteonecrosis in the medial femoral condyle (SONK) may be a subchondral insufficiency fracture, which may be associated with underlying low bone mineral density (BMD). However, the pathogenesis of SONK is considered to be multifactorial. Women over 60 years of age tend to have higher incidence of SONK and low BMD. We investigated whether there may be an association between low BMD and SONK in women who are more than 60 years old.
  
  
  METHODS
  We compared the BMD of 26 women with SONK within 3 months after the onset of symptoms to that of 26 control women with medial knee osteoarthritis (OA). All the SONK patients had typical clinical presentations and met specified criteria on MRI. The BMDs measured at the lumbar spine, ipsilateral femoral neck, and knee condyles and the ratios of medial condyle BMD to lateral condyle BMD (medial-lateral ratios) in the femur and tibia were compared between the two groups. The medial-lateral ratios were used as parameters for comparisons of the BMDs at both condyles.
  
  
  RESULTS
  The mean femoral neck, lateral femoral condyle, and lateral tibial condyle BMDs were between x% and y% lower in the SONK patients than in the OA patients (p < 0.001). The mean femoral and tibial medial-lateral ratios were statistically significantly higher in the SONK patients than in the OA patients.
  
  
  CONCLUSIONS
  A proportion of women over 60 years of age have low BMD that progresses rapidly after menopause and can precipitate a microfracture. These findings support the subchondral insufficiency fracture theory for the onset of SONK based on low BMD.
authors.affiliation: Department of Orthopaedic Surgery, Yokohama City University Medical Center, Yokohama City, Kanagawa, Japan. akamatsu@yokohama-cu.ac.jp
authors.forename: Yasushi
authors.initials: Y
authors.lastname: Akamatsu
authors.forename: Naoto
authors.initials: N
authors.lastname: Mitsugi
authors.forename: Takeshi
authors.initials: T
authors.lastname: Hayashi
authors.forename: Hideo
authors.initials: H
authors.lastname: Kobayashi
authors.forename: Tomoyuki
authors.initials: T
authors.lastname: Saito
mesh_terms: D015502:Absorptiometry, Photon; D000368:Aged; D018771:Arthralgia / Q000209:etiology; D015519:Bone Density / Q000502:physiology*; D001851:Bone Diseases, Metabolic / Q000175:diagnosis / Q000503:physiopathology; D016022:Case-Control Studies; D005260:Female; D005272:Femur Neck; D015775:Fractures, Stress / Q000503:physiopathology; D006801:Humans; D007719:Knee Joint; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D010020:Osteonecrosis / Q000175:diagnosis / Q000503:physiopathology*; D015663:Osteoporosis, Postmenopausal / Q000175:diagnosis / Q000503:physiopathology; D013977:Tibia; D014057:Tomography, X-Ray Computed