title: [The role of opioid system in peculiarities of anti-anxiety effect of peptide anxiolytic selank].
abstract: Peculiarities of the anxiolytic effects of selank (heptapeptide analog of taftsin) under reduced activity of opioid system upon acute administration of naloxone have been studied in BALB/C and C57BL/6 inbred mice with high and low levels of anxiety, with passive and active emotional stress reaction phenotypes in the open field (OF) test. Selank (0.25 mg/kg, i.p.) per se exhibited anxiolytic effect in BALB/C mice by increasing the general locomotor activity, with no effects on the behavior of C57BL/6 mice in the OF test. Naloxone (1.0 mg/kg, i.p.) per se evoked swift runaway in OF peripheral areas in BALB/C mice while "freezing" the reaction in C57BL/6 mice with active response to stress under the same conditions. Pretreatment with naloxone attenuated the sensitivity to selank in BALB/C mice whereas the response to anxiolytic effects of peptide was increased in C57BL/6 mice. The data obtained reveal a new target for selank in CNS and indicate significance of the activity of enkephalin-opioid system in individual sensitivity to selank.
authors.forename: I I
authors.initials: II
authors.lastname: Kozlovskiĭ
authors.forename: L A
authors.initials: LA
authors.lastname: Andreeva
authors.forename: M M
authors.initials: MM
authors.lastname: Kozlovskaia
authors.forename: A V
authors.initials: AV
authors.lastname: Nadorova
authors.forename: L G
authors.initials: LG
authors.lastname: Kolik
mesh_terms: D000701:Analgesics, Opioid / Q000494:pharmacology; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D001007:Anxiety / Q000188:drug therapy* / Q000523:psychology; D002490:Central Nervous System / Q000187:drug effects* / Q000502:physiology; D004924:Escape Reaction / Q000187:drug effects; D046352:Freezing Reaction, Cataleptic / Q000187:drug effects; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009270:Naloxone / Q000494:pharmacology*; D009292:Narcotic Antagonists; D009842:Oligopeptides / Q000494:pharmacology*; D011957:Receptors, Opioid / Q000502:physiology; D013045:Species Specificity; D013315:Stress, Psychological / Q000188:drug therapy* / Q000523:psychology
chemical_list: D000701:Analgesics, Opioid; D014151:Anti-Anxiety Agents; D009292:Narcotic Antagonists; D009842:Oligopeptides; D011957:Receptors, Opioid; D009270:Naloxone; C100827:TP 7