title: Alveolar gas exchange and tissue deoxygenation during exercise in type 1 diabetes patients and healthy controls.
abstract: We used near-infrared spectroscopy to investigate whether leg and arm skeletal muscle and cerebral deoxygenation differ during incremental cycling exercise in men with type 1 diabetes (T1D, n=10, mean±SD age 33±7 years) and healthy control men (matched by age, anthrometry, and self-reported physical activity, CON, n=10, 32±7 years) to seek an explanation for lower aerobic capacity (˙VO2peak) often reported in T1D. T1D had lower ˙VO2peak (35±4mlkg(-1)min(-1) vs. 43±8mlkg(-1)min(-1), P<0.01) and peak work rate (219±33W vs. 290±44W, P<0.001) than CON. Leg muscle deoxygenation (↑ [deoxyhemoglobin]; ↓ tissue saturation index) was greater in T1D than CON at a given absolute submaximal work rate, but not at peak exercise, while arm muscle and cerebral deoxygenation were similar. Thus, in T1D compared with CON, faster leg muscle deoxygenation suggests limited circulatory ability to increase O(2) delivery as a plausible explanation for lower ˙VO2peak and earlier fatigue in T1D.
authors.affiliation: Department of Sports and Exercise Medicine, Institute of Clinical Medicine, University of Helsinki, Helsinki, Finland. juha.peltonen@helsinki.fi
authors.forename: Juha E
authors.initials: JE
authors.lastname: Peltonen
authors.forename: Anne S
authors.initials: AS
authors.lastname: Koponen
authors.forename: Katri
authors.initials: K
authors.lastname: Pullinen
authors.forename: Harriet
authors.initials: H
authors.lastname: Hägglund
authors.forename: Jyrki M
authors.initials: JM
authors.lastname: Aho
authors.forename: Heikki
authors.initials: H
authors.lastname: Kyröläinen
authors.forename: Heikki O
authors.initials: HO
authors.lastname: Tikkanen
mesh_terms: D000222:Adaptation, Physiological; D000328:Adult; D016022:Case-Control Studies; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism* / Q000503:physiopathology; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005625:Frontal Lobe / Q000378:metabolism; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008297:Male; D016555:Matched-Pair Analysis; D018482:Muscle, Skeletal / Q000378:metabolism*; D010101:Oxygen Consumption / Q000502:physiology*; D011650:Pulmonary Alveoli / Q000502:physiology; D011659:Pulmonary Gas Exchange / Q000502:physiology*; D012016:Reference Values; D019265:Spectroscopy, Near-Infrared
chemical_list: D006454:Hemoglobins; C100003:deoxyhemoglobin