title: Decline of semen quality among 10 932 males consulting for couple infertility over a 20-year period in Marseille, France.
abstract: Semen from 10 932 male partners of infertile couples was analysed and sperm parameter trends were evaluated at the Reproduction Biology Laboratory of the University Hospital of Marseille (France) between 1988 and 2007. After 3-6 days of abstinence, semen samples were collected. Measurements of seminal fluid volume, pH, sperm concentration, total sperm count, motility and detailed morphology of spermatozoa were performed. Sperm parameters were analysed on the entire population and in men with normal total numeration (≥40 million per ejaculate). The whole population demonstrated declining trends in sperm concentration (1.5% per year), total sperm count (1.6% per year), total motility (0.4% per year), rapid motility (5.5% per year) and normal morphology (2.2% per year). In the group of selected samples with total normal sperm count, the same trends of sperm quality deterioration with time were observed. Our results clearly indicate that the quality of semen decreased in this population over the study period.
authors.affiliation: Reproduction Biology Laboratory, Conception Hospital, AP-HM, Marseille 13005, France.
authors.forename: Cendrine
authors.initials: C
authors.lastname: Geoffroy-Siraudin
authors.forename: Anderson Dieudonné
authors.initials: AD
authors.lastname: Loundou
authors.forename: Fanny
authors.initials: F
authors.lastname: Romain
authors.forename: Vincent
authors.initials: V
authors.lastname: Achard
authors.forename: Blandine
authors.initials: B
authors.lastname: Courbière
authors.forename: Marie-Hélène
authors.initials: MH
authors.lastname: Perrard
authors.forename: Philippe
authors.initials: P
authors.lastname: Durand
authors.forename: Marie-Roberte
authors.initials: MR
authors.lastname: Guichaoua
mesh_terms: D000328:Adult; D005298:Fertility; D005602:France; D006801:Humans; D007248:Infertility, Male / Q000473:pathology / Q000503:physiopathology*; D016014:Linear Models; D008297:Male; D012661:Semen / Q000502:physiology*; D013076:Sperm Count / Q000639:trends*; D013081:Sperm Motility; D013094:Spermatozoa / Q000166:cytology* / Q000502:physiology