title: Pagetoid reticulosis in a prepubescent boy successfully treated with photodynamic therapy.
abstract: Pagetoid reticulosis or Woringer-Kolopp disease (WKD) is a rare variant of mycosis fungoides, consisting of localized patches or plaques containing intraepidermal proliferations of neoplastic T cells in a pagetoid distribution (similar to that of the adenocarcinomatous cells found in Paget disease of the nipple), which typically affects middle-aged and elderly men. We report a trial of photodynamic therapy (PDT) with topical aminolaevulinic acid (ALA), carried out on a 10-year-old boy with a solitary lesion of WKD on his foot, to avoid the long-term problems associated with the typical treatments for WKD of surgery and/or local irradiation. The plaque progressively flattened during treatment, and after nine PDT sessions over 13 months, the patient was clinically free of disease. PDT may be a viable alternative to surgery and local irradiation for localized cutaneous T-cell lymphoma, including WKD, especially in younger patients.
authors.affiliation: Department of Dermatology Dermatopathology Section, Boston University School of Medicine, Boston, MA 02118, USA.
authors.forename: G W
authors.initials: GW
authors.lastname: Mendese
authors.forename: A
authors.initials: A
authors.lastname: Beckford
authors.forename: N
authors.initials: N
authors.lastname: Krejci
authors.forename: M
authors.initials: M
authors.lastname: Mahalingam
authors.forename: L
authors.initials: L
authors.lastname: Goldberg
authors.forename: B A
authors.initials: BA
authors.lastname: Gilchrest
mesh_terms: D000622:Aminolevulinic Acid / Q000627:therapeutic use*; D002648:Child; D005533:Foot Dermatoses / Q000188:drug therapy*; D006801:Humans; D008297:Male; D056267:Pagetoid Reticulosis / Q000188:drug therapy*; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D017319:Photosensitizing Agents; D000622:Aminolevulinic Acid