title: Effects of restricted fructose access on body weight and blood pressure circadian rhythms.
abstract: High-fructose diet is known to produce cardiovascular and metabolic pathologies. The objective was to determine whether the timing of high fructose (10% liquid solution) intake affect the metabolic and cardiovascular outcomes. Male C57BL mice with radiotelemetric probes were divided into four groups: (1) 24 h water (control); (2) 24 h fructose (F24); (3) 12 h fructose during the light phase (F12L); (4) 12 h fructose during the dark phase (F12D). All fructose groups had higher fluid intake. Body weight was increased in mice on restricted access with no difference in total caloric intake. Fasting glycemia was higher in groups with restricted access. F24 mice showed a fructose-induced blood pressure increase during the dark period. Blood pressure circadian rhythms were absent in F12L mice. Results suggest that the timing of fructose intake is an important variable in the etiology of cardiovascular and metabolic pathologies produced by high fructose consumption.
authors.affiliation: Department of Pharmacology & Toxicology, Boonshoft School of Medicine, Wright State University, 3640 Colonel Glenn Highway, Dayton, OH 45435, USA.
authors.forename: Danielle
authors.initials: D
authors.lastname: Senador
authors.forename: Swapnil
authors.initials: S
authors.lastname: Shewale
authors.forename: Maria Claudia
authors.initials: MC
authors.lastname: Irigoyen
authors.forename: Khalid M
authors.initials: KM
authors.lastname: Elased
authors.forename: Mariana
authors.initials: M
authors.lastname: Morris
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000187:drug effects* / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects*; D002940:Circadian Rhythm / Q000187:drug effects*; D004326:Drinking / Q000187:drug effects; D005632:Fructose / Q000494:pharmacology*; D005951:Glucose Tolerance Test; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D013686:Telemetry
chemical_list: D001786:Blood Glucose; D005632:Fructose