title: Uterine smooth muscle tumors of uncertain malignant potential: diagnostic challenges and therapeutic dilemmas. Report of 2 cases and review of the literature.
abstract: Morphologically, there exist variants of uterine smooth muscle tumors that cannot be clearly interpreted and classified as benign or malignant. Because their behavior and clinical prognosis is also uncertain, the World Health Organization has termed these "smooth muscle tumors of uncertain malignant potential" (STUMP). Herein we describe 2 cases, present a review of the literature, and highlight the diagnostic challenges and therapeutic dilemmas associated with uterine STUMP in myomectomy specimens from women who wish to maintain or enhance their fertility. The clinical course of residual STUMP remains speculative.
authors.affiliation: Department of Obstetrics and Gynecology, University of Western Ontario, London, Ontario, Canada.
authors.forename: George A
authors.initials: GA
authors.lastname: Vilos
authors.forename: Jennifer
authors.initials: J
authors.lastname: Marks
authors.forename: Helen C
authors.initials: HC
authors.lastname: Ettler
authors.forename: Angelos G
authors.initials: AG
authors.lastname: Vilos
authors.forename: Michel
authors.initials: M
authors.lastname: Prefontaine
authors.forename: Basim
authors.initials: B
authors.lastname: Abu-Rafea
mesh_terms: D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D018231:Leiomyomatosis / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D007890:Leiomyosarcoma / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D019042:Muscle Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D011379:Prognosis; D018235:Smooth Muscle Tumor / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy; D014594:Uterine Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy