title: Polymeric dual-slab waveguide interferometer for biochemical sensing applications.
abstract: A polymer based dual-slab waveguide Young's interferometer was demonstrated for biochemical sensing. Evanescent field is utilized for probing the binding events of biomolecules on the waveguide surface. Refractive index sensing in analyte and protein adsorption on the sensing surface were investigated with glucose de-ionized water solution and bovine serum albumin, immunoglobulin G solutions in phosphate buffered saline buffer. A detection limit of 10(-5) RIU and 4 pg/mm(2) was achieved for homogeneous and surface sensing, respectively. Also, the influence of water absorption inside the polymeric device on the measurement stability was evaluated. The results indicate that the waveguide polymer sensor fabricated with the spin coating technique can achieve a satisfactory sensitivity for homogeneous refractive index sensing and, as well, for monitoring molecular binding events on the surface.
authors.affiliation: Optoelectronics and Measurement Techniques Laboratory, University of Oulu, Oulu, Finland. meng.wang@ee.oulu.fi
authors.forename: Meng
authors.initials: M
authors.lastname: Wang
authors.forename: Sanna
authors.initials: S
authors.lastname: Uusitalo
authors.forename: Christina
authors.initials: C
authors.lastname: Liedert
authors.forename: Jussi
authors.initials: J
authors.lastname: Hiltunen
authors.forename: Leena
authors.initials: L
authors.lastname: Hakalahti
authors.forename: Risto
authors.initials: R
authors.lastname: Myllylä
mesh_terms: D000042:Absorption; D000327:Adsorption; D000818:Animals; D001671:Biochemistry / Q000379:methods*; D015374:Biosensing Techniques; D002417:Cattle; D005947:Glucose / Q000737:chemistry; D007368:Interferometry / Q000379:methods*; D015233:Models, Statistical; D008962:Models, Theoretical; D011108:Polymers / Q000737:chemistry*; D012031:Refractometry; D012710:Serum Albumin, Bovine / Q000737:chemistry; D014867:Water / Q000737:chemistry
chemical_list: D011108:Polymers; D014867:Water; D012710:Serum Albumin, Bovine; D005947:Glucose