title: Role of common blaOXA-24/OXA-40-carrying platforms and plasmids in the spread of OXA-24/OXA-40 among Acinetobacter species clinical isolates.
abstract: The spread of OXA-24/OXA-40 (OXA-24/40)-producing Acinetobacter spp. in the Iberian Peninsula has been strongly influenced by clonal expansion, but the role of horizontal gene transfer has scarcely been explored. bla(OXA-24/40)-carrying plasmids and genetic environments were characterized in representative (n = 15) Acinetobacter species clinical isolates (obtained between 2001 and 2007) by Acinetobacter baumannii PCR-based replicon typing, sequencing, hybridization, and restriction fragment length polymorphism. Besides the identification of bla(OXA-24/40) within the chromosomes of some isolates, the circulation of common bla(OXA-24/40)-carrying plasmids (30-kb repA_AB; 10-kb aci2) and genetic backbones among Acinetobacter spp. was demonstrated.
authors.affiliation: REQUIMTE, Laboratório de Microbiologia, Faculdade de Farmácia, Universidade do Porto, Porto, Portugal.
authors.forename: Filipa
authors.initials: F
authors.lastname: Grosso
authors.forename: Sandra
authors.initials: S
authors.lastname: Quinteira
authors.forename: Laurent
authors.initials: L
authors.lastname: Poirel
authors.forename: Ângela
authors.initials: Â
authors.lastname: Novais
authors.forename: Luísa
authors.initials: L
authors.lastname: Peixe
mesh_terms: D000150:Acinetobacter / Q000201:enzymology* / Q000235:genetics*; D040981:Acinetobacter baumannii / Q000201:enzymology / Q000235:genetics; D022761:Gene Transfer, Horizontal / Q000235:genetics; D008969:Molecular Sequence Data; D010957:Plasmids / Q000235:genetics*; D016133:Polymerase Chain Reaction; D001618:beta-Lactamases / Q000235:genetics
chemical_list: D001618:beta-Lactamases; C410345:beta-lactamase OXA-24; C488541:beta-lactamase OXA-40, Acinetobacter baumannii