title: Monocyte-derived interferon-alpha primed dendritic cells in the pathogenesis of psoriasis: new pieces in the puzzle.
abstract: Psoriasis is a common chronic inflammatory skin disorder with serious clinical, psychosocial, and economic consequences. There is much evidence that different dendritic cell (DC) subsets, various proinflammatory cytokines and Toll-like receptors (TLRs) have a central role in the pathogenesis of the disease. One of the early events in psoriatic inflammation is the secretion of interferon (IFN)-α by activated plasmacytoid DCs, a special DC subset present in symptomless psoriatic skin. Secreted IFN-α along with other proinflammatory cytokines can lead to monocyte-derived DC (moDC) development, which might contribute to T-helper (Th)1 and Th17 lymphocyte differentiation/activation and to keratinocyte proliferation. Recently it was proven that interleukin (IL)-12 and IL-23 play a critical role in this process. Additionally in psoriatic lesions, Th1 and Th17 lympocytes can interact with monocytes and instruct these cells to differentiate into Th1- and Th17-promoting moDCs, further governing the formation and function of specialized moDC subsets. The concept we present here focuses on the initial and central role of IFN-α, on the importance of other proinflammatory cytokines, on TLR stimulation and on the effect of T lymphocytes in priming moDCs, which may play an important role in initiating and maintaining psoriasis.
authors.affiliation: Department of Dermatology and Allergology, University of Szeged, Szeged, Hungary. farkas@mail.derma.szote.u-szeged.hu
authors.forename: Arpád
authors.initials: A
authors.lastname: Farkas
authors.forename: Lajos
authors.initials: L
authors.lastname: Kemény
mesh_terms: D002454:Cell Differentiation / Q000276:immunology; D016207:Cytokines / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology / Q000473:pathology; D006801:Humans; D018836:Inflammation Mediators / Q000276:immunology; D016898:Interferon-alpha / Q000276:immunology; D015603:Keratinocytes / Q000276:immunology / Q000473:pathology; D008213:Lymphocyte Activation; D018448:Models, Immunological; D009000:Monocytes / Q000276:immunology / Q000473:pathology; D011565:Psoriasis / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D018417:Th1 Cells / Q000276:immunology / Q000473:pathology; D058504:Th17 Cells / Q000276:immunology / Q000473:pathology; D051193:Toll-Like Receptors / Q000276:immunology
chemical_list: D016207:Cytokines; D018836:Inflammation Mediators; D016898:Interferon-alpha; D051193:Toll-Like Receptors