title: sRNAs and the virulence of Salmonella enterica serovar Typhimurium.
abstract: The combination of genomics and high-throughput cDNA sequencing technologies has facilitated the identification of many small RNAs (sRNAs) that play a central role in the post-transcriptional gene regulation of Salmonella enterica serovar Typhimurium. To date, most of the functionally characterized sRNAs have been involved in the regulation of processes which are not directly linked to virulence. Just five sRNAs have been found to affect the ability of Salmonella to replicate within mammalian cells, but the precise regulatory mechanisms that are used by sRNAs to control Salmonella pathogenicity at the post-transcriptional level remain to be identified. It is anticipated that an improved understanding of sRNA biology will shed new light on the virulence of Salmonella.
authors.affiliation: Department of Microbiology, School of Genetics and Microbiology, Moyne Institute of Preventive Medicine, Trinity College Dublin, Dublin, Ireland.
authors.forename: Magali
authors.initials: M
authors.lastname: Hébrard
authors.forename: Carsten
authors.initials: C
authors.lastname: Kröger
authors.forename: Shabarinath
authors.initials: S
authors.lastname: Srikumar
authors.forename: Aoife
authors.initials: A
authors.lastname: Colgan
authors.forename: Kristian
authors.initials: K
authors.lastname: Händler
authors.forename: Jay C D
authors.initials: JC
authors.lastname: Hinton
mesh_terms: D000818:Animals; D001483:Base Sequence; D017124:Conserved Sequence; D015964:Gene Expression Regulation, Bacterial; D053263:Gene Regulatory Networks; D005798:Genes, Bacterial; D006790:Host-Parasite Interactions / Q000235:genetics; D006801:Humans; D034622:RNA Interference; D058727:RNA, Small Untranslated / Q000235:genetics / Q000502:physiology; D012480:Salmonella Infections / Q000382:microbiology*; D012486:Salmonella typhimurium / Q000235:genetics / Q000472:pathogenicity; D014774:Virulence / Q000235:genetics
chemical_list: D058727:RNA, Small Untranslated