title: Supramolecular polymers as dynamic multicomponent cellular uptake carriers.
abstract: Supramolecular synthesis represents a flexible approach to the generation of dynamic multicomponent materials with tunable properties. Here, cellular uptake systems based on dynamic supramolecular copolymers have been developed using a combination of differently functionalized discotic molecules. Discotics featuring peripheral amine functionalities that endow the supramolecular polymer with cellular uptake capabilities were readily synthesized. This enabled the uptake of otherwise cell-impermeable discotics via cotransport as a function of supramolecular coassembly. Dynamic multicomponent and multifunctional supramolecular polymers represent a novel and unique platform for modular cellular uptake systems.
authors.affiliation: Laboratory of Chemical Biology, Department of Biomedical Engineering, Eindhoven University of Technology, Den Dolech 2, 5612 AZ Eindhoven, The Netherlands.
authors.forename: Katja
authors.initials: K
authors.lastname: Petkau-Milroy
authors.forename: Michael H
authors.initials: MH
authors.lastname: Sonntag
authors.forename: Arthur H A M
authors.initials: AH
authors.lastname: van Onzen
authors.forename: Luc
authors.initials: L
authors.lastname: Brunsveld
mesh_terms: D001692:Biological Transport; D002470:Cell Survival; D004337:Drug Carriers / Q000737:chemistry* / Q000378:metabolism*; D006367:HeLa Cells; D006801:Humans; D011108:Polymers / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D004337:Drug Carriers; D011108:Polymers