title: Imported Plasmodium falciparum malaria in HIV-infected patients: a report of two cases.
abstract: As HIV becomes a chronic infection, an increasing number of HIV-infected patients are travelling to malaria-endemic areas. Association of malaria with HIV/AIDS can be clinically severe. Severe falciparum malaria is a medical emergency that is associated with a high mortality, even when treated in an Intensive Care Unit. This article describes two cases of HIV-positive patients, who returned from malaria-endemic areas and presented a parasitaemia > 5% of erythrocytes and clinical signs of severe falciparum malaria, both with > 350 CD4 cell count/μl, absence of chemoprophylaxis and successful response. Factors like drug interactions and the possible implication of anti-malarial therapy bioavailability are all especially interesting in HIV-malaria co-infections.
authors.affiliation: Department of Microbiology and Parasitology, La Paz University Hospital-IdiPAZ, Paseo de la Castellana 261, 28046 Madrid, Spain. ssgarciab.hulp@salud.madrid.org
authors.forename: Silvia
authors.initials: S
authors.lastname: García-Bujalance
authors.forename: Carolina Navarro-San
authors.initials: CN
authors.lastname: Francisco
authors.forename: José M
authors.initials: JM
authors.lastname: Rubio
authors.forename: José R
authors.initials: JR
authors.lastname: Arribas
authors.forename: Avelino
authors.initials: A
authors.lastname: Gutierrez
mesh_terms: D000328:Adult; D000962:Antimalarials / Q000008:administration & dosage; D018791:CD4 Lymphocyte Count; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D016778:Malaria, Falciparum / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D018512:Parasitemia / Q000175:diagnosis / Q000473:pathology; D010963:Plasmodium falciparum / Q000302:isolation & purification*; D014195:Travel; D016896:Treatment Outcome
chemical_list: D000962:Antimalarials