title: T inflammatory memory CD8 T cells participate to antiviral response and generate secondary memory cells with an advantage in XCL1 production.
abstract: Besides the classically described subsets of memory CD8 T cells generated under infectious conditions, are T inflammatory memory cells generated under sterile priming conditions, such as sensitization to allergens. Although not fully differentiated as pathogen-induced memory cells, they display memory properties that distinguish them from naive CD8 T cells. Given these memory cells are generated in an antigen-specific context that is devoid of pathogen-derived danger signals and CD4 T cell help, we herein questioned whether they maintained their activation and differentiation potential, could be recruited in an immune response directed against a pathogen expressing their cognate antigen and further differentiate in fully competent secondary memory cells. We show that T inflammatory memory cells can indeed take part to the immune response triggered by a viral infection, differentiate into secondary effectors and further generate typical central memory CD8 T cells and effector memory CD8 T cells. Furthermore, the secondary memory cells they generate display a functional advantage over primary memory cells in their capacity to produce TNF-α and the XCL1 chemokine. These results suggest that cross-reactive stimulations and differentiation of cells directed against allergens or self into fully competent pathogen-induced memory cells might have incidences in inflammatory immuno-pathologies.
authors.affiliation: Université de Lyon, Lyon, France.
authors.forename: Virginie
authors.initials: V
authors.lastname: Jubin
authors.forename: Erwan
authors.initials: E
authors.lastname: Ventre
authors.forename: Yann
authors.initials: Y
authors.lastname: Leverrier
authors.forename: Sophia
authors.initials: S
authors.lastname: Djebali
authors.forename: Katia
authors.initials: K
authors.lastname: Mayol
authors.forename: Martine
authors.initials: M
authors.lastname: Tomkowiak
authors.forename: Julien
authors.initials: J
authors.lastname: Mafille
authors.forename: Marie
authors.initials: M
authors.lastname: Teixeira
authors.forename: Denise Y-L
authors.initials: DY
authors.lastname: Teoh
authors.forename: Bruno
authors.initials: B
authors.lastname: Lina
authors.forename: Thierry
authors.initials: T
authors.lastname: Walzer
authors.forename: Christophe
authors.initials: C
authors.lastname: Arpin
authors.forename: Jacqueline
authors.initials: J
authors.lastname: Marvel
mesh_terms: D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D019744:Chemokines, C / Q000096:biosynthesis / Q000276:immunology*; D003429:Cross Reactions / Q000235:genetics / Q000276:immunology; D007156:Immunologic Memory; D008213:Lymphocyte Activation; D051379:Mice; D008822:Mice, Transgenic; D009976:Orthomyxoviridae Infections / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis / Q000276:immunology
chemical_list: D019744:Chemokines, C; D014409:Tumor Necrosis Factor-alpha; C486249:Xcl1 protein, mouse