title: Peripheral neuropathic symptoms in celiac disease and inflammatory bowel disease.
abstract: OBJECTIVE
  An association between celiac disease (CD) and peripheral neuropathy (PN) has been reported.
  
  
  METHODS
  Patients with CD and/or inflammatory bowel disease (IBD) were recruited from the gastroenterology clinics at a medical center and local support groups. Control subjects without CD or IBD were recruited from the staff of the medical center as well as relatives and attendees at support groups. Each participant completed a survey that used two validated PN instruments to define and characterize PN.
  
  
  RESULTS
  In the CD group, 38.9% met criteria for PN compared with 38.7% in the IBD group (P = 0.97) and 20.5% in the control group (P < 0.001). On multiple logistic regression, the odds of PN after adjusting for age, gender, diabetes, vitamin B12 deficiency, and cancer history were increased for CD (odds ratio, 2.51; 95% confidence interval, 1.82-3.47) and IBD (odds ratio, 2.78; 95% confidence interval, 1.85-4.18).
  
  
  CONCLUSIONS
  PN is more often found in patients with CD and/or IBD than in the general population.
authors.affiliation: Department of Medicine, Division of Digestive and Liver Diseases, Columbia University Medical Center, New York, NY, USA.
authors.forename: Ting-Chin David
authors.initials: TC
authors.lastname: Shen
authors.forename: Benjamin
authors.initials: B
authors.lastname: Lebwohl
authors.forename: Himanshu
authors.initials: H
authors.lastname: Verma
authors.forename: Nikhil
authors.initials: N
authors.lastname: Kumta
authors.forename: Christina
authors.initials: C
authors.lastname: Tennyson
authors.forename: Suzanne
authors.initials: S
authors.lastname: Lewis
authors.forename: Ellen
authors.initials: E
authors.lastname: Scherl
authors.forename: Arun
authors.initials: A
authors.lastname: Swaminath
authors.forename: Kristina M
authors.initials: KM
authors.lastname: Capiak
authors.forename: Dan
authors.initials: D
authors.lastname: DiGiacomo
authors.forename: Brian P
authors.initials: BP
authors.lastname: Bosworth
authors.forename: Thomas H
authors.initials: TH
authors.lastname: Brannagan
authors.forename: Peter H R
authors.initials: PH
authors.lastname: Green
mesh_terms: D000328:Adult; D002446:Celiac Disease / Q000150:complications* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications* / Q000453:epidemiology*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010523:Peripheral Nervous System Diseases / Q000150:complications* / Q000178:diet therapy / Q000453:epidemiology*; D012148:Restless Legs Syndrome / Q000503:physiopathology; D012189:Retrospective Studies; D012720:Severity of Illness Index; D011795:Surveys and Questionnaires; D014815:Vitamins / Q000008:administration & dosage; D055815:Young Adult
chemical_list: D014815:Vitamins