title: [Biomarkers in rheumatology. Biomarkers and imaging for the diagnosis and stratification of rheumatoid arthritis and spondylarthritis in the ArthroMark network funded by the Federal Ministry of Education and Research].
abstract: The introduction of biologics has continuously increased the demand for biomarkers for early diagnosis and therapeutic stratification. ArthroMark, a research network funded by the Federal Ministry of Education and Research, aims to establish such biomarkers for rheumatoid arthritis and spondyloarthritides. Biobanks and previous work on genotyping, gene expression and autoreactivity profiling build the basis. Bioinformatic networks will help to harmonize the investigations and a clinical study with modern imaging techniques to characterize the functional relevance of the new biomarkers as effectively as possible. To validate the markers for diagnostic application the network aims to expand gradually.
authors.affiliation: Medizinische Klinik m.S. Rheumatologie und Klinische Immunologie, Charité-Universitätsmedizin Berlin, Campus Mitte, Charitéplatz 1, 10117, Berlin, Deutschland. thomas.haeupl@charite.de
authors.forename: T
authors.initials: T
authors.lastname: Häupl
authors.forename: H
authors.initials: H
authors.lastname: Appel
authors.forename: M
authors.initials: M
authors.lastname: Backhaus
authors.forename: H
authors.initials: H
authors.lastname: Burkhardt
authors.forename: M
authors.initials: M
authors.lastname: Grünke
authors.forename: A
authors.initials: A
authors.lastname: Grützkau
authors.forename: B
authors.initials: B
authors.lastname: Hoppe
authors.forename: J
authors.initials: J
authors.lastname: Listing
authors.forename: B
authors.initials: B
authors.lastname: Ostendorf
authors.forename: M
authors.initials: M
authors.lastname: Rudwaleit
authors.forename: J
authors.initials: J
authors.lastname: Sieper
authors.forename: A
authors.initials: A
authors.lastname: Skapenko
authors.forename: K
authors.initials: K
authors.lastname: Skriner
authors.forename: T
authors.initials: T
authors.lastname: Sörensen
authors.forename: B
authors.initials: B
authors.lastname: Stuhlmüller
authors.forename: A
authors.initials: A
authors.lastname: Zink
authors.forename: H
authors.initials: H
authors.lastname: Schulze-Koops
authors.forename: G-R
authors.initials: GR
authors.lastname: Burmester
mesh_terms: D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000175:diagnosis*; D015415:Biomarkers / Q000097:blood*; D005858:Germany; D006801:Humans; D017410:Practice Guidelines as Topic; D012219:Rheumatology / Q000592:standards*; D025241:Spondylarthritis / Q000097:blood* / Q000175:diagnosis*
chemical_list: D015415:Biomarkers