title: Asymmetric cyclization reactions of allenoates with imines or α,β-unsaturated ketones catalyzed by organocatalysts derived from cinchona alkaloids.
abstract: Lewis base-catalyzed cyclization reactions of allenoates with electron-deficient olefins and imines have been demonstrated by the preparation of biologically active natural products and pharmaceutically interesting substances and have emerged as powerful synthetic tools in the rapid construction of cyclic molecular complexity. In contrast to phosphine-containing Lewis bases, nitrogen-containing Lewis base amines display markedly different reaction profiles; however, this area is not well-developed. Herein we summarize the recent progress in this emerging field and outline the challenges ahead.
authors.affiliation: State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P. R. China.
authors.forename: Cheng-Kui
authors.initials: CK
authors.lastname: Pei
authors.forename: Min
authors.initials: M
authors.lastname: Shi
mesh_terms: D002384:Catalysis; D002930:Cinchona Alkaloids / Q000737:chemistry*; D003500:Cyclization; D007097:Imines / Q000737:chemistry*; D007659:Ketones / Q000737:chemistry*; D058115:Lewis Bases / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: D002930:Cinchona Alkaloids; D007097:Imines; D007659:Ketones; D058115:Lewis Bases