title: Access to cyclic or branched peptides using bis(2-sulfanylethyl)amido side-chain derivatives of Asp and Glu.
abstract: Bis(2-sulfanylethyl)amido (SEA) side-chain derivatives of aspartic and glutamic acids enable the synthesis of tail-to-side chain cyclic or branched peptides using standard Fmoc-SPPS followed by SEA native peptide ligation.
authors.affiliation: CNRS UMR 8161, Université Lille Nord de France, Institut Pasteur de Lille, 59021, Lille, France.
authors.forename: Emmanuelle
authors.initials: E
authors.lastname: Boll
authors.forename: Julien
authors.initials: J
authors.lastname: Dheur
authors.forename: Hervé
authors.initials: H
authors.lastname: Drobecq
authors.forename: Oleg
authors.initials: O
authors.lastname: Melnyk
mesh_terms: D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000737:chemistry*; D004220:Disulfides / Q000138:chemical synthesis / Q000737:chemistry*; D018698:Glutamic Acid / Q000031:analogs & derivatives* / Q000737:chemistry*; D015394:Molecular Structure; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D004220:Disulfides; D010455:Peptides; D010456:Peptides, Cyclic; D013438:Sulfhydryl Compounds; D001224:Aspartic Acid; D018698:Glutamic Acid