title: Serum Fetuin-A and Pentraxin3 in hemodialysis and renal transplant patients.
abstract: OBJECTIVE
  The aim of the present study was to evaluate of Fetuin-A and Pentraxin3 (PTX3) as the main factors for vascular calcification and inflammation in hemodialysis (HD) and renal transplant (RT) patients.
  
  
  METHODS
  Serum was obtained from 45 stable chronic HD patients and 44 stable RT recipients. Biochemical factors, intact Parathormone, high-sensitive C-reactive protein (hsCRP), Fetuin-A and PTX3 levels were determined by standard methods.
  
  
  RESULTS
  In the RT recipients PTX3 level was significantly higher than the HD patients [5.78(1.09-20.36) ng/mL vs. 1.65(0.24-7.89) ng/mL, p ≤ 0.001]. Serum Fetuin-A concentration was significantly higher in the HD compared to RT group [43.39(27.75-81.48) ng/mL vs. 38.76(22.26-89.07) ng/mL, p=0.020]. hsCRP level was also higher in the HD than the RT group [2.90(0.1-8.50) mg/L vs. 1.1(0.1-7.9) mg/L, p=0.003].
  
  
  CONCLUSIONS
  Although our study shows that serum PTX3 is increased and Fetuin-A is decreased after successful RT, their direct role on atherosclerosis needs further studies in the future.
authors.affiliation: Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
authors.forename: Hassan
authors.initials: H
authors.lastname: Argani
authors.forename: Amir
authors.initials: A
authors.lastname: Ghorbanihaghjo
authors.forename: Ghodratollah
authors.initials: G
authors.lastname: Panahi
authors.forename: Nadereh
authors.initials: N
authors.lastname: Rashtchizadeh
authors.forename: Javid
authors.initials: J
authors.lastname: Safa
authors.forename: Saeed Mahmoudi
authors.initials: SM
authors.lastname: Meimand
mesh_terms: D000328:Adult; D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy; D016030:Kidney Transplantation / Q000379:methods*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D000683:Serum Amyloid P-Component / Q000378:metabolism*; D060749:alpha-2-HS-Glycoprotein / Q000378:metabolism*; D000099153:Pentraxins
chemical_list: D002097:C-Reactive Protein; D000683:Serum Amyloid P-Component; D060749:alpha-2-HS-Glycoprotein; D000099153:Pentraxins