title: Proline sulphonamide-catalysed Yamada-Otani condensation: reaction development, substrate scope and scaffold reactivity.
abstract: The development of a proline sulphonamide-catalysed method for enantioselective and diastereoselective construction of functionalized cyclohexenones is described. Impact of catalyst structure as well as solvent effects and additives are explored. A significant substrate scope is demonstrated by variation of both the aldehyde and the enone components. Diastereoselective derivatization of the cyclohexenone scaffold illustrates its utility as a building block for chemical synthesis.
authors.affiliation: College of Chemistry & Chemical Engineering, Central South University, Changsha, Hunan 410083, China.
authors.forename: Hua
authors.initials: H
authors.lastname: Yang
authors.forename: Somdev
authors.initials: S
authors.lastname: Banerjee
authors.forename: Rich G
authors.initials: RG
authors.lastname: Carter
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D002384:Catalysis; D008958:Models, Molecular; D015394:Molecular Structure; D011392:Proline / Q000737:chemistry; D013237:Stereoisomerism; D013449:Sulfonamides / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D013449:Sulfonamides; D011392:Proline