title: Synthesis, study on anti-arthritic, anti-inflammatory activity and toxicity of some novel bis-oxy cyclophane diamides.
abstract: A series of bis-oxy cyclophane diamides with bis(aminomethyl)m-terphenyl as spacer have been synthesized and characterized from spectral and analytical data. All the cyclophane diamides exhibit better anti-arthritic activity than the reference drug viz. diclofenac sodium. Some of the cyclophane diamides exhibit good anti-inflammatory activity. The cyclophane amide 4 and 5 do not show any evidence of mutagenicity and cytotoxicity.
authors.affiliation: Department of Organic Chemistry, University of Madras, Guindy Campus, Chennai, India. perumalrajakumar@gmail.com
authors.forename: Perumal
authors.initials: P
authors.lastname: Rajakumar
authors.forename: Ramar
authors.initials: R
authors.lastname: Padmanabhan
authors.forename: Navin
authors.initials: N
authors.lastname: Rajesh
mesh_terms: D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D003958:Diamide / Q000138:chemical synthesis / Q000737:chemistry* / Q000633:toxicity; D004008:Diclofenac / Q000737:chemistry; D009152:Mutagenicity Tests; D012486:Salmonella typhimurium / Q000187:drug effects
chemical_list: D000893:Anti-Inflammatory Agents; D003958:Diamide; D004008:Diclofenac