title: Two tridentate Schiff base ligands and their mononuclear cobalt (III) complexes: Synthesis, characterization, antibacterial and antifungal activities.
abstract: Two Schiff base ligands (HL1, HL2) and their Co(III) complexes, [Co(HL1)(L1)] (1) and [Co(HL2)(L2)] (2) [where HL1=2-((E)-(2-hydroxyethylimino)methyl)-4-chlorophenol and HL2=2-((E)-(2-hydroxyethylimino)methyl)-4-bromophenol] were synthesized and characterized using spectroscopic methods. The crystal structures of 1 and 2 have been re-determined by single crystal diffraction at 100K. The ligands and their Co(III) complexes were screened for antibacterial and antifungal activities by the disc diffusion, microdilution broth and single spore culture techniques. The antimicrobial activity of the Co(III) complexes and the free ligands exhibit antimicrobial properties and the Co(III) complexes show enhanced inhibitory activity compared with their parent ligand.
authors.affiliation: Department of Physics, Faculty of Science and Art, Balikesir University, 10145 Balıkesir, Turkey.
authors.forename: Elif
authors.initials: E
authors.lastname: Gungor
authors.forename: Selma
authors.initials: S
authors.lastname: Celen
authors.forename: Dilek
authors.initials: D
authors.lastname: Azaz
authors.forename: Hulya
authors.initials: H
authors.lastname: Kara
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D003035:Cobalt / Q000494:pharmacology*; D056831:Coordination Complexes / Q000138:chemical synthesis* / Q000494:pharmacology*; D018360:Crystallography, X-Ray; D004583:Electrons; D005658:Fungi / Q000187:drug effects; D006860:Hydrogen Bonding / Q000187:drug effects; D008024:Ligands; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D012545:Schiff Bases / Q000138:chemical synthesis* / Q000494:pharmacology*; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D056831:Coordination Complexes; D008024:Ligands; D012545:Schiff Bases; D003035:Cobalt