title: Oral acetazolamide after Boston keratoprosthesis in Stevens-Johnson syndrome.
abstract: BACKGROUND
  Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) is a rare but severe and sometimes fatal condition associated with exposure to medications; sulfamethoxazole is among the most common causes. We sought to address the safety of acetazolamide, a chemically related compound, in patients with prior SJS/TEN and glaucoma. A retrospective case series is described of patients at the Massachusetts Eye and Ear Infirmary who underwent keratoprosthesis surgery for corneal blindness from SJS/TEN, and later required oral acetazolamide for elevated intraocular pressure.
  
  
  RESULTS
  Over the last 10 years, 17 patients with SJS/TEN received a Boston keratoprosthesis. Of these, 11 developed elevated intraocular pressure that required administration of oral acetazolamide. One of 11 developed a mild allergic reaction, but no patient experienced a recurrence of SJS/TEN or any severe adverse reaction.
  
  
  CONCLUSIONS
  Although an increase in the rate of recurrent SJS/TEN due to oral acetazolamide would not necessarily be apparent after treating only 11 patients, in our series, acetazolamide administration was well tolerated without serious sequela.
authors.affiliation: Massachusetts Eye and Ear Infirmary, Harvard Medical School, Department of Ophthalmology, Boston, MA, USA.
authors.forename: Radhika
authors.initials: R
authors.lastname: Kumar
authors.forename: Claes H
authors.initials: CH
authors.lastname: Dohlman
authors.forename: James
authors.initials: J
authors.lastname: Chodosh
mesh_terms: D000086:Acetazolamide / Q000008:administration & dosage*; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D001900:Boston; D002257:Carbonic Anhydrase Inhibitors / Q000008:administration & dosage*; D003315:Cornea / Q000601:surgery; D005260:Female; D005901:Glaucoma / Q000517:prevention & control*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D019904:Polymethyl Methacrylate; D019736:Prostheses and Implants; D012189:Retrospective Studies; D013262:Stevens-Johnson Syndrome / Q000150:complications / Q000601:surgery; D014025:Titanium
chemical_list: D002257:Carbonic Anhydrase Inhibitors; D019904:Polymethyl Methacrylate; D014025:Titanium; D000086:Acetazolamide