title: Effects of intravesical dexpanthenol use on lipid peroxidation and bladder histology in a chemical cystitis animal model.
abstract: OBJECTIVE
  To demonstrate the effects of intravesical dexpanthenol use on bladder histology and lipid peroxidation in a chemical cystitis animal model.
  
  
  METHODS
  Thirty-five New Zealand rabbits were divided into 3 groups. Cystitis was conducted with transurethral intravesical hydrochloric acid instillation on the subjects in groups I and II. Then, Group I subjects were transurethrally administered intravesical dexpanthenol therapy twice a week, Group II subjects were given only intravesical isotonic NaCl instillation, and Group III subjects were administered intravesical isotonic NaCl instillation without conducting chemical cystitis to create the same stress. Treatment schemes of all groups were arranged in the same manner. After 6-week therapy, the rabbits were sacrificed and histopathologic investigations were carried out to demonstrate changes in the urinary bladder. Serum and tissue malondialdehyde (MDA) values were examined to investigate the effect of dexpanthenol on lipid peroxidation.
  
  
  RESULTS
  We observed that the basal membrane and mucosal integrity were maintained, inflammatory cells were suppressed, and MDA levels decreased in group I, which received dexpanthenol therapy. However, it was also observed that mucosal integrity was spoiled, numerous inflammatory cells were accumulated, and MDA levels were significantly increased in group II, which was administered isotonic NaCl.
  
  
  CONCLUSIONS
  In light of our findings, intravesical dexpanthenol therapy could be a new therapeutic approach in the treatment of interstitial cystitis because of its low cost and acceptable side effects.
authors.affiliation: Department of Urology, Gaziantep University, Gaziantep, Turkey. Dromerbayrak@yahoo.com
authors.forename: Omer
authors.initials: O
authors.lastname: Bayrak
authors.forename: Ilker
authors.initials: I
authors.lastname: Seckiner
authors.forename: Mehmet
authors.initials: M
authors.lastname: Solakhan
authors.forename: Metin
authors.initials: M
authors.lastname: Karakok
authors.forename: Sakip M
authors.initials: SM
authors.lastname: Erturhan
authors.forename: Faruk
authors.initials: F
authors.lastname: Yagci
mesh_terms: D000283:Administration, Intravesical; D000818:Animals; D018856:Cystitis, Interstitial / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology*; D004195:Disease Models, Animal; D005260:Female; D006851:Hydrochloric Acid; D015227:Lipid Peroxidation / Q000187:drug effects; D008315:Malondialdehyde / Q000097:blood / Q000378:metabolism*; D010205:Pantothenic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D011817:Rabbits; D018709:Statistics, Nonparametric; D014803:Vitamin B Complex / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D014803:Vitamin B Complex; D010205:Pantothenic Acid; C007288:dexpanthenol; D008315:Malondialdehyde; D006851:Hydrochloric Acid