title: Analysis of common and emerging brominated flame retardants in house dust using ultrasonic assisted solvent extraction and on-line sample preparation via column switching with liquid chromatography-mass spectrometry.
abstract: Brominated flame retardants (BFRs) are persistent and widespread chemicals. Therefore human beings are exposed to BFRs. House dust may be one source of exposure and contains a lot of xenobiotics in relatively high concentrations. In contrast to common GC-MS based methods here an online LC-MS/MS method is presented to quantify 16 BFRs in dust using ultrasonic solvent extraction as a single sample work up step. LOQ from 0.6 (tetrabromobisphenol A) to 80 (polybrominated diphenylethers (BDE 28) ng/g dust were achieved. Data for accuracy, precision and recovery are presented and are comparable to common LC-MS/MS methods in different matrices. In addition 5 real house dust samples were analyzed with high concentration (535 ng/g) for bis(2-ethyl-1-hexyl)tetrabromophthalate which is a novel alternative BFRs to replace common BDE's.
authors.affiliation: Bavarian Health and Food Safety Authority, Chemical Safety and Toxicology, Pfarrstrasse 3, 80538 München, Germany.
authors.forename: E K
authors.initials: EK
authors.lastname: Kopp
authors.forename: H
authors.initials: H
authors.lastname: Fromme
authors.forename: W
authors.initials: W
authors.lastname: Völkel
mesh_terms: D016902:Air Pollution, Indoor / Q000032:analysis*; D005591:Chemical Fractionation / Q000379:methods*; D002853:Chromatography, Liquid / Q000379:methods; D004391:Dust / Q000032:analysis*; D005411:Flame Retardants / Q000032:analysis* / Q000302:isolation & purification; D055768:Halogenated Diphenyl Ethers / Q000032:analysis* / Q000302:isolation & purification; D057230:Limit of Detection; D016014:Linear Models; D011075:Polybrominated Biphenyls / Q000032:analysis* / Q000302:isolation & purification; D015203:Reproducibility of Results; D013010:Sonication; D053719:Tandem Mass Spectrometry / Q000379:methods
chemical_list: D004391:Dust; D005411:Flame Retardants; D055768:Halogenated Diphenyl Ethers; D011075:Polybrominated Biphenyls