title: Improvement of signal-to-interference ratio and signal-to-noise ratio in nerve cuff electrode systems.
abstract: Cuff electrodes are effective for chronic electroneurogram (ENG) recording while minimizing nerve damage. However, the ENG signals are usually contaminated by electromyogram (EMG) activity from the surrounding muscles, stimulus artifacts produced by the electrical stimulation and noise generated in the first stage of the neural signal amplifier. This paper proposed a new cuff electrode to reduce the interference from EMG signals and stimulus artifacts. As a result, when an additional middle electrode was placed at the center of the cuff electrode, a significant improvement in the signal-to-interference ratio was achieved at 11% for the EMG signals and 12% for the stimulus artifacts when compared to a conventional tripolar cuff. Furthermore, a new low-noise amplifier was proposed to improve the signal-to-noise ratio. The circuit was designed based on a noise analysis to minimize the noise, and the results show that the total noise of the amplifier was below 1 μV for a cuff impedance of 1 kΩ and a frequency bandwidth of 300 to 5000 Hz.
authors.affiliation: Biomedical Research Institute, Korea Institute of Science and Technology, 39-1 Hawolgok-dong, Seongbuk-gu, Seoul, Korea.
authors.forename: Jun-Uk
authors.initials: JU
authors.lastname: Chu
authors.forename: Kang-Il
authors.initials: KI
authors.lastname: Song
authors.forename: Sungmin
authors.initials: S
authors.lastname: Han
authors.forename: Soo Hyun
authors.initials: SH
authors.lastname: Lee
authors.forename: Jinseok
authors.initials: J
authors.lastname: Kim
authors.forename: Ji Yoon
authors.initials: JY
authors.lastname: Kang
authors.forename: Dosik
authors.initials: D
authors.lastname: Hwang
authors.forename: Jun-Kyo Francis
authors.initials: JK
authors.lastname: Suh
authors.forename: Kuiwon
authors.initials: K
authors.lastname: Choi
authors.forename: Inchan
authors.initials: I
authors.lastname: Youn
mesh_terms: D000669:Amplifiers, Electronic; D000818:Animals; D016477:Artifacts; D017097:Electric Impedance; D004567:Electrodes, Implanted; D004576:Electromyography / Q000295:instrumentation* / Q000379:methods*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012584:Sciatic Nerve / Q000502:physiology*; D012815:Signal Processing, Computer-Assisted; D059629:Signal-To-Noise Ratio; D012965:Sodium Chloride
chemical_list: D012965:Sodium Chloride