title: Adverse cardiac events during catecholamine vasopressor therapy: a prospective observational study.
abstract: OBJECTIVE
  To determine the incidence of and risk factors for adverse cardiac events during catecholamine vasopressor therapy in surgical intensive care unit patients with cardiovascular failure.
  
  
  METHODS
  The occurrence of any of seven predefined adverse cardiac events (prolonged elevated heart rate, tachyarrhythmia, myocardial cell damage, acute cardiac arrest or death, pulmonary hypertension-induced right heart dysfunction, reduction of systemic blood flow) was prospectively recorded during catecholamine vasopressor therapy lasting at least 12 h.
  
  
  RESULTS
  Fifty-four of 112 study patients developed a total of 114 adverse cardiac events, an incidence of 48.2 % (95 % CI, 38.8-57.6 %). New-onset tachyarrhythmia (49.1 %), prolonged elevated heart rate (23.7 %), and myocardial cell damage (17.5 %) occurred most frequently. Aside from chronic liver diseases, factors independently associated with the occurrence of adverse cardiac events included need for renal replacement therapy, disease severity (assessed by the Simplified Acute Physiology Score II), number of catecholamine vasopressors (OR, 1.73; 95 % CI, 1.08-2.77; p = 0.02) and duration of catecholamine vasopressor therapy (OR, 1.01; 95 % CI, 1-1.01; p = 0.002). Patients developing adverse cardiac events were on catecholamine vasopressors (p < 0.001) and mechanical ventilation (p < 0.001) for longer and had longer intensive care unit stays (p < 0.001) and greater mortality (25.9 vs. 1.7 %; p < 0.001) than patients who did not.
  
  
  CONCLUSIONS
  Adverse cardiac events occurred in 48.2 % of surgical intensive care unit patients with cardiovascular failure and were related to morbidity and mortality. The extent and duration of catecholamine vasopressor therapy were independently associated with and may contribute to the pathogenesis of adverse cardiac events.
authors.affiliation: Department of Intensive Care Medicine, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland. christian.schmittinger@gmail.com
authors.forename: Christian A
authors.initials: CA
authors.lastname: Schmittinger
authors.forename: Christian
authors.initials: C
authors.lastname: Torgersen
authors.forename: Günter
authors.initials: G
authors.lastname: Luckner
authors.forename: Daniel C H
authors.initials: DC
authors.lastname: Schröder
authors.forename: Ingo
authors.initials: I
authors.lastname: Lorenz
authors.forename: Martin W
authors.initials: MW
authors.lastname: Dünser
mesh_terms: D000368:Aged; D002395:Catecholamines / Q000009:adverse effects* / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000139:chemically induced*; D011446:Prospective Studies; D013610:Tachycardia / Q000139:chemically induced*; D014662:Vasoconstrictor Agents / Q000009:adverse effects* / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D002395:Catecholamines; D014662:Vasoconstrictor Agents