title: Self-assembling DNA-peptide hybrids: morphological consequences of oligonucleotide grafting to a pathogenic amyloid fibrils forming dipeptide.
abstract: For the very first time, highly efficient synthesis of DNA-peptide hybrids to scaffold self-assembled nanostructures is described. Oligonucleotide conjugation to the diphenylalanine dipeptide triggers a morphological transition from fibrillar to vesicular structures which may potentially be used as delivery vehicles, since they exhibit pH triggered release.
authors.affiliation: Department of Inorganic and Analytical Chemistry, University of Geneva, Sciences II, 30, quai Ernest-Ansermet, CH-1211 Geneva 4, Switzerland.
authors.forename: Nidhi
authors.initials: N
authors.lastname: Gour
authors.forename: Dawid
authors.initials: D
authors.lastname: Kedracki
authors.forename: Ilyès
authors.initials: I
authors.lastname: Safir
authors.forename: Kien Xuan
authors.initials: KX
authors.lastname: Ngo
authors.forename: Corinne
authors.initials: C
authors.lastname: Vebert-Nardin
mesh_terms: D000165:Acridine Orange; D000682:Amyloid / Q000737:chemistry*; D004247:DNA / Q000737:chemistry*; D004151:Dipeptides / Q000737:chemistry*; D005456:Fluorescent Dyes; D006801:Humans; D006863:Hydrogen-Ion Concentration; D018625:Microscopy, Atomic Force; D046529:Microscopy, Electron, Transmission; D058726:Nanoconjugates / Q000737:chemistry* / Q000648:ultrastructure; D009841:Oligonucleotides / Q000737:chemistry*; D010316:Particle Size; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000737:chemistry
chemical_list: D000682:Amyloid; D004151:Dipeptides; D005456:Fluorescent Dyes; D058726:Nanoconjugates; D009841:Oligonucleotides; C026650:phenylalanylphenylalanine; D010649:Phenylalanine; D004247:DNA; D000165:Acridine Orange