title: Why is joint range of motion limited in patients with cerebral palsy?
abstract: Patients with spastic cerebral palsy of the upper limb typically present with various problems including an impaired range of motion that affects the positioning of the upper extremity. This impaired range of motion often develops into contractures that further limit functioning of the spastic hand and arm. Understanding why these contractures develop in cerebral palsy will affect the selection of patients suitable for surgical treatment as well as the choice for specific surgical procedures. The generally accepted hypothesis in patients with spastic cerebral palsy is that the hyper-excitability of the stretch reflex combined with increased muscle tone result in extreme angles of the involved joints at rest. Ultimately, these extreme joint angles are thought to result in fixed joint postures. There is no consensus in the literature concerning the pathophysiology of this process. Several hypotheses associated with inactivity and overactivity have been tested by examining the secondary changes in spastic muscle and its surrounding tissue. All hypotheses implicate different secondary changes that consequently require different clinical approaches. In this review, the different hypotheses concerning the development of limited joint range of motion in cerebral palsy are discussed in relation to their secondary changes on the musculoskeletal system.
authors.affiliation: Department of Plastic, Reconstructive and Hand surgery, Academic Medical Centre, Amsterdam, the Netherlands. m.debruin@amc.uva.nl
authors.forename: M
authors.initials: M
authors.lastname: de Bruin
authors.forename: M J C
authors.initials: MJ
authors.lastname: Smeulders
authors.forename: M
authors.initials: M
authors.lastname: Kreulen
mesh_terms: D002547:Cerebral Palsy / Q000150:complications / Q000473:pathology / Q000503:physiopathology*; D003286:Contracture / Q000209:etiology* / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D009128:Muscle Spasticity / Q000150:complications / Q000473:pathology / Q000503:physiopathology; D018579:Patient Selection; D016059:Range of Motion, Articular / Q000502:physiology*; D034941:Upper Extremity