title: Genetic architecture of body size in mammals.
abstract: Much of the heritability for human stature is caused by mutations of small-to-medium effect. This is because detrimental pleiotropy restricts large-effect mutations to very low frequencies.
authors.affiliation: Faculty of Land and Environment, University of Melbourne, Parkville, Victoria 3010, Australia. kathryn.kemper@dpi.vic.gov.au
authors.forename: Kathryn E
authors.initials: KE
authors.lastname: Kemper
authors.forename: Peter M
authors.initials: PM
authors.lastname: Visscher
authors.forename: Michael E
authors.initials: ME
authors.lastname: Goddard
mesh_terms: D000483:Alleles; D000818:Animals; D049628:Body Size / Q000235:genetics* / Q000502:physiology; D056726:Genetic Association Studies / Q000379:methods; D056426:Genetic Loci; D058685:Genetic Pleiotropy; D006801:Humans; D015810:Linkage Disequilibrium; D008322:Mammals / Q000235:genetics* / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D009154:Mutation; D059645:Mutation Rate; D010375:Pedigree; D011110:Polymorphism, Genetic