title: In vitro chemoenzymatic and in vivo biocatalytic syntheses of new beauvericin analogues.
abstract: New beauvericins have been synthesized using the nonribosomal peptide synthetase BbBEAS from the entomopathogenic fungus Beauveria bassiana. Chemical diversity was generated by in vitro chemoenzymatic and in vivo whole cell biocatalytic syntheses using either a B. bassiana mutant or an E. coli strain expressing the bbBeas gene.
authors.affiliation: Technische Universität Berlin, Institut für Chemie, Strasse des 17. Juni 124, 10623 Berlin, Germany.
authors.forename: Diana
authors.initials: D
authors.lastname: Matthes
authors.forename: Lennart
authors.initials: L
authors.lastname: Richter
authors.forename: Jane
authors.initials: J
authors.lastname: Müller
authors.forename: Alexander
authors.initials: A
authors.lastname: Denisiuk
authors.forename: Sven C
authors.initials: SC
authors.lastname: Feifel
authors.forename: Yuquan
authors.initials: Y
authors.lastname: Xu
authors.forename: Patricia
authors.initials: P
authors.lastname: Espinosa-Artiles
authors.forename: Roderich D
authors.initials: RD
authors.lastname: Süssmuth
authors.forename: István
authors.initials: I
authors.lastname: Molnár
mesh_terms: D052982:Beauveria / Q000737:chemistry / Q000201:enzymology* / Q000235:genetics; D055162:Biocatalysis; D003001:Cloning, Molecular; D047630:Depsipeptides / Q000737:chemistry* / Q000378:metabolism*; D004926:Escherichia coli / Q000235:genetics; D009154:Mutation; D010453:Peptide Synthases / Q000235:genetics / Q000378:metabolism*
chemical_list: D047630:Depsipeptides; C004456:beauvericin; D010453:Peptide Synthases