title: Simultaneous occurrence of foetal and neonatal alloimmune thrombocytopenia and neonatal neutropenia due to maternal neutrophilic autoantibodies: a case study and review of the literature.
abstract: Foetal and neonatal alloimmune thrombocytopenia (FNAIT) and neonatal neutropenia caused by maternal autoantibodies against neutrophils are rare disorders. We describe a newborn with severe thrombocytopenia and intracerebral bleeding caused by maternal anti-HPA-3a alloantibodies and mild neutropenia caused by maternal autoantibodies against HNA-1b. This appears to be the first case of simultaneous occurrence of these two conditions.
  
  
  CONCLUSIONS
  This case report and review of the literature demonstrate that anti-HPA-3a antibodies can be overlooked by standard assays.
authors.affiliation: Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Denmark. ellen.morling.taaning@rh.regionh.dk
authors.forename: Ellen
authors.initials: E
authors.lastname: Taaning
authors.forename: Lise
authors.initials: L
authors.lastname: Jensen
authors.forename: Kim
authors.initials: K
authors.lastname: Varming
mesh_terms: D016824:Antigens, Human Platelet / Q000276:immunology; D001792:Blood Platelets / Q000276:immunology; D002543:Cerebral Hemorrhage / Q000276:immunology*; D005315:Fetal Diseases / Q000276:immunology*; D006801:Humans; D007231:Infant, Newborn; D007519:Isoantigens / Q000276:immunology; D008297:Male; D009503:Neutropenia / Q000276:immunology*; D009504:Neutrophils / Q000276:immunology; D017713:Platelet Transfusion; D054098:Thrombocytopenia, Neonatal Alloimmune / Q000276:immunology*
chemical_list: C044561:3a alloantigen, human; D016824:Antigens, Human Platelet; D007519:Isoantigens; C067704:neutrophil-specific antigen NA1, human