title: Non-coding RNA and its potential role in Mycobacterium tuberculosis pathogenesis.
abstract: It is estimated that one third of the human population is infected with Mycobacterium tuberculosis. Efforts to understand the molecular basis of its gene regulation have been focused on identification of protein encoding genes and regulons implicated in pathogenesis. Recently, a number of studies have described the identification of several non-coding RNAs that are likely to contribute significantly to the regulatory networks responsible for adaptation and virulence in M. tuberculosis. We have reviewed emerging information on the presence and abundance of different types of non-coding RNA in M. tuberculosis and consider their potential contribution to the adaptive responses that underlie disease pathogenesis.
authors.affiliation: Division of Mycobacterial Research, MRC National Institute for Medical Research, London, UK. karnvig@nimr.mrc.ac.uk
authors.forename: Kristine
authors.initials: K
authors.lastname: Arnvig
authors.forename: Douglas
authors.initials: D
authors.lastname: Young
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000502:physiology; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D054884:Host-Pathogen Interactions; D006801:Humans; D009169:Mycobacterium tuberculosis / Q000235:genetics / Q000472:pathogenicity / Q000502:physiology*; D012329:RNA, Bacterial / Q000235:genetics / Q000502:physiology*; D058727:RNA, Small Untranslated / Q000235:genetics / Q000502:physiology*; D058928:Riboswitch; D013312:Stress, Physiological; D014376:Tuberculosis / Q000382:microbiology*; D014774:Virulence
chemical_list: D001426:Bacterial Proteins; D012329:RNA, Bacterial; D058727:RNA, Small Untranslated; D058928:Riboswitch