title: Eicosanoids in skin inflammation.
abstract: Eicosanoids play an integral part in homeostatic mechanisms related to skin health and structural integrity. They also mediate inflammatory events developed in response to environmental factors, such as exposure to ultraviolet radiation, and inflammatory and allergic disorders, including psoriasis and atopic dermatitis. This review article discusses biochemical aspects related to cutaneous eicosanoid metabolism, the contribution of these potent autacoids to skin inflammation and related conditions, and considers the importance of nutritional supplementation with bioactives such as omega-3 and omega-6 polyunsaturated fatty acids and plant-derived antioxidants as means of addressing skin health issues.
authors.affiliation: School of Pharmacy and Centre for Skin Sciences, School of Life Sciences, University of Bradford, Richmond Road, Bradford BD7 1DP, UK. a.nicolaou@bradford.ac.uk
authors.forename: Anna
authors.initials: A
authors.lastname: Nicolaou
mesh_terms: D000818:Animals; D003872:Dermatitis / Q000178:diet therapy / Q000276:immunology / Q000378:metabolism*; D003876:Dermatitis, Atopic / Q000178:diet therapy / Q000276:immunology / Q000378:metabolism; D019587:Dietary Supplements; D015777:Eicosanoids / Q000378:metabolism*; D015525:Fatty Acids, Omega-3 / Q000378:metabolism / Q000627:therapeutic use; D005395:Fish Oils / Q000378:metabolism / Q000627:therapeutic use; D006801:Humans; D018384:Oxidative Stress; D011565:Psoriasis / Q000178:diet therapy / Q000276:immunology / Q000378:metabolism; D012867:Skin / Q000201:enzymology / Q000276:immunology / Q000378:metabolism*; D013471:Sunburn / Q000178:diet therapy / Q000276:immunology / Q000378:metabolism
chemical_list: D015777:Eicosanoids; D015525:Fatty Acids, Omega-3; D005395:Fish Oils