title: Reduced lung function is independently associated with increased risk of type 2 diabetes in Korean men.
abstract: BACKGROUND
  Reduced lung function is associated with incident insulin resistance and diabetes. The aim of this study was to assess the relationship between lung function and incident type 2 diabetes in Korean men.
  
  
  METHODS
  This study included 9,220 men (mean age: 41.4 years) without type 2 diabetes at baseline who were followed for five years. Subjects were divided into four groups according to baseline forced vital capacity (FVC) (% predicted) and forced expiratory volume in one second (FEV1) (% predicted) quartiles. The incidence of type 2 diabetes at follow-up was compared according to FVC and FEV1 quartiles.
  
  
  RESULTS
  The overall incidence of type 2 diabetes was 2.2%. Reduced lung function was significantly associated with the incidence of type 2 diabetes after adjusting for age, BMI, education, smoking, exercise, alcohol, and HOMA-IR. Both FVC and FEV1 were negatively associated with type 2 diabetes (P < 0.05). In non-obese subjects with BMI < 25, the lowest quartile of FVC and FEV1 had a significantly higher odds ratio for type 2 diabetes compared with the highest quartile after adjusting for age and BMI (2.15 [95% CI 1.02-4.57] and 2.19 [95% CI 1.09-4.42]).
  
  
  CONCLUSIONS
  Reduced lung function is independently associated with the incidence of type 2 diabetes in Korean men.
authors.affiliation: Department of Cardiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
authors.forename: Chang-Hee
authors.initials: CH
authors.lastname: Kwon
authors.forename: Eun-Jung
authors.initials: EJ
authors.lastname: Rhee
authors.forename: Jae-Uk
authors.initials: JU
authors.lastname: Song
authors.forename: Jung-Tae
authors.initials: JT
authors.lastname: Kim
authors.forename: Hyon Joo
authors.initials: HJ
authors.lastname: Kwag
authors.forename: Ki-Chul
authors.initials: KC
authors.lastname: Sung
mesh_terms: D000328:Adult; D044466:Asian People / Q000706:statistics & numerical data*; D015415:Biomarkers / Q000097:blood; D016009:Chi-Square Distribution; D003920:Diabetes Mellitus / Q000175:diagnosis / Q000208:ethnology* / Q000503:physiopathology; D005500:Follow-Up Studies; D005541:Forced Expiratory Volume; D006801:Humans; D015994:Incidence; D007333:Insulin Resistance / Q000208:ethnology; D016015:Logistic Models; D008168:Lung / Q000503:physiopathology*; D008297:Male; D015999:Multivariate Analysis; D016016:Proportional Hazards Models; D056910:Republic of Korea / Q000453:epidemiology; D018570:Risk Assessment; D012307:Risk Factors; D013147:Spirometry; D013997:Time Factors; D014797:Vital Capacity
chemical_list: D015415:Biomarkers