title: Carcinogenic polycyclic aromatic hydrocarbons in umbilical cord blood of human neonates from Guiyu, China.
abstract: Unregulated electronic-waste recycling results in serious environmental pollution of polycyclic aromatic hydrocarbons (PAHs) in Guiyu, China. We evaluated the body burden of seven carcinogenic PAHs and potential health risks for neonates. Umbilical cord blood (UCB) samples were collected from Guiyu (n=103), and the control area of Chaonan (n=80), China. PAHs in UCB were determined by gas chromatography/mass spectrometry. The median ∑7c-PAH concentration was 108.05 ppb in UCB samples from Guiyu, vs. 79.36 ppb in samples from Chaonan. Residence in Guiyu and longer cooking time of food during the gestation period were significant factors contributing to the ∑7c-PAH level. Benzo[a]anthracene (BaA), chrysene (Chr), and benzo[a]pyrene (BaP) were found to correlate with reduced neonatal height and gestational age. Infants experiencing adverse birth outcomes, on the whole, displayed higher BaA, Chr, and BaP levels compared to those with normal outcomes. We conclude that maternal PAH exposure results in fetal accumulation of toxic PAHs, and that such prenatal exposure correlates with adverse effects on neonatal health.
authors.affiliation: Analytic Cytology Laboratory and the Key Immunopathology Laboratory of Guangdong Province, Shantou University Medical College, Shantou, China.
authors.forename: Yongyong
authors.initials: Y
authors.lastname: Guo
authors.forename: Xia
authors.initials: X
authors.lastname: Huo
authors.forename: Kusheng
authors.initials: K
authors.lastname: Wu
authors.forename: Junxiao
authors.initials: J
authors.lastname: Liu
authors.forename: Yuling
authors.initials: Y
authors.lastname: Zhang
authors.forename: Xijin
authors.initials: X
authors.lastname: Xu
mesh_terms: D000328:Adult; D002681:China; D059029:Electronic Waste / Q000032:analysis*; D004781:Environmental Exposure; D004785:Environmental Pollutants / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D018811:Maternal Exposure; D011084:Polycyclic Aromatic Hydrocarbons / Q000097:blood*; D011247:Pregnancy; D055815:Young Adult
chemical_list: D004785:Environmental Pollutants; D011084:Polycyclic Aromatic Hydrocarbons