title: Enantioselective copper-aminopyridine-catalyzed aza-Henry reaction with chelating N-(2-pyridyl)sulfonyl imines.
abstract: This article describes a copper-catalyzed aza-Henry reaction. Copper complexes of camphor-derived aminopyridines catalyze the addition of nitromethane to N-(2-pyridyl)sulfonyl aldimines to give the corresponding β-nitrosulfonamides with good yields and variable enantiomeric excesses (up to 83%). An example of transformation of these compounds into N-(2-pyridyl)sulfonyl-α-amino acids and deprotection of the sulfonamide with Mg-MeOH is provided.
authors.affiliation: Departament de Química Orgànica, Facultat de Química, Universitat de València, Burjassot, Spain. gonzalo.blay@uv.es
authors.forename: Gonzalo
authors.initials: G
authors.lastname: Blay
authors.forename: Ana
authors.initials: A
authors.lastname: Escamilla
authors.forename: Víctor
authors.initials: V
authors.lastname: Hernández-Olmos
authors.forename: José R
authors.initials: JR
authors.lastname: Pedro
authors.forename: Amparo
authors.initials: A
authors.lastname: Sanz-Marco