title: The effect of a controlled 8-week metabolic ward based lysine supplementation on muscle function, insulin sensitivity and leucine kinetics in young men.
abstract: OBJECTIVE
  The 2007 FAO/WHO/UNU lysine requirement is 30 mgkg(-1)d(-1). Developing country populations may be at risk of lysine deficiency, with effects on muscle and its function. The effect of an 8 wk lysine supplementation diet on muscle mass and function was assessed.
  
  
  METHODS
  Healthy, under and well-nourished men were studied before and after 8 wk, during which low (n=20) and high (n=20) lysine diets were consumed. The low lysine diets (∼25 and ∼40 mgkg(-1)d(-1) for under and well-nourished respectively) were based on the subjects' habitual lysine intake, while the high lysine diet supplied 80 mgkg(-1)d(-1). Anthropometry, muscle function, insulin sensitivity (IS) and leucine kinetics were measured before and after the experimental period.
  
  
  RESULTS
  The high lysine diet had a small positive effect (about +7.5%) on muscle strength, but no effect on other parameters. Over the 8 wk period in the whole group, the change in muscle strength correlated with the change in muscle mass (r=0.5, P=0.001), while the change in muscle mass correlated with the change in IS (r=0.3, P=0.04), but there were no intake specific differences.
  
  
  CONCLUSIONS
  Over an 8 wk controlled feeding period, an intake of 80 mg lysine kg(-1)d(-1) had a small positive effect on muscle strength, but no other effects.
authors.affiliation: Division of Nutrition, St John's Research Institute, St John's National Academy of Health Sciences, Bangalore 560034, India. uma@sjri.res.in
authors.forename: Uma S
authors.initials: US
authors.lastname: Unni
authors.forename: Tony
authors.initials: T
authors.lastname: Raj
authors.forename: Sucharita
authors.initials: S
authors.lastname: Sambashivaiah
authors.forename: Rebecca
authors.initials: R
authors.lastname: Kuriyan
authors.forename: Sheila
authors.initials: S
authors.lastname: Uthappa
authors.forename: Mario
authors.initials: M
authors.lastname: Vaz
authors.forename: Meredith M
authors.initials: MM
authors.lastname: Regan
authors.forename: Anura V
authors.initials: AV
authors.lastname: Kurpad
mesh_terms: D000293:Adolescent; D000328:Adult; D000886:Anthropometry; D001823:Body Composition / Q000187:drug effects; D004032:Diet; D019587:Dietary Supplements; D006801:Humans; D007333:Insulin Resistance; D007930:Leucine / Q000378:metabolism*; D008239:Lysine / Q000008:administration & dosage*; D008297:Male; D053580:Muscle Strength / Q000187:drug effects*; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000378:metabolism; D009751:Nutritional Requirements; D055815:Young Adult
chemical_list: D007930:Leucine; D008239:Lysine