title: Contrast-induced nephropathy in patients with renal insufficiency undergoing contrast-enhanced MDCT.
abstract: OBJECTIVE
  To evaluate the safety of contrast-enhanced MDCT in patients with renal impairment.
  
  
  METHODS
  We conducted a retrospective review of 938 patients with stable renal insufficiency (eGFR between 15 and 60 ml/min) who underwent contrast-enhanced MDCT. SCr levels were measured at baseline and 48-72 h after contrast medium administration. The incidence of contrast-induced nephropathy (CIN) in the total study population was assessed. As a control group, 1,164 separate patients with renal insufficiency who did not receive contrast medium for CT were also reviewed.
  
  
  RESULTS
  The overall incidence of CIN in the patient population with renal insufficiency was 6.1 %; the incidence was 4.4 %, 10.5 % and 10.0 % for patients whose eGFR was 45-60, 30-45 and ≤30 ml/min, respectively (P < 0.01). In the control group, 5.8 % of patients showed an increase in the SCr level from the baseline. The increase in the SCr level showed no significant difference between the patients who received CM and those who did not (P = 0.82)                                               CONCLUSIONS:                          The risk of CIN from contrast-enhanced MDCT in patients with renal insufficiency appeared to be low, and there was no significant difference in the incidence of CIN in comparison with patients who did not receive CM.
  
  
  CONCLUSIONS
  • The contrast medium used for multidetector CT can induce nephropathy.                                                  • Contrast-induced nephropathy (CIN) developed in 6.1 % of patients with renal insufficiency.                                                  • However, nephropathy developed in 5.8 % of similar patients not receiving contrast medium.                                                  • Thus, the risk of CIN associated with MDCT appears to be low.                                                  • Special care should still be taken in patients with renal insufficiency.
authors.affiliation: Department of Radiology, Graduate School of Medicine, Nippon Medical School, 1-1-5 Sendagi Bunkyo, Tokyo, 1138602, Japan. rywakana@nms.ac.jp
authors.forename: Ryusuke
authors.initials: R
authors.lastname: Murakami
authors.forename: Hiromitsu
authors.initials: H
authors.lastname: Hayashi
authors.forename: Ken-Ichi
authors.initials: K
authors.lastname: Sugizaki
authors.forename: Tamiko
authors.initials: T
authors.lastname: Yoshida
authors.forename: Emi
authors.initials: E
authors.lastname: Okazaki
authors.forename: Shin-Ichiro
authors.initials: S
authors.lastname: Kumita
authors.forename: Chojin
authors.initials: C
authors.lastname: Owan
mesh_terms: D000368:Aged; D015331:Cohort Studies; D003287:Contrast Media / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced*; D008297:Male; D051437:Renal Insufficiency / Q000000981:diagnostic imaging*; D012189:Retrospective Studies; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media