title: Pasteurella multocida toxin interaction with host cells: entry and cellular effects.
abstract: The mitogenic dermonecrotic toxin from Pasteurella multocida (PMT) is a 1285-residue multipartite protein that belongs to the A-B family of bacterial protein toxins. Through its G-protein-deamidating activity on the α subunits of heterotrimeric G(q)-, G(i)- and G(12/13)-proteins, PMT potently stimulates downstream mitogenic, calcium, and cytoskeletal signaling pathways. These activities lead to pleiotropic effects in different cell types, which ultimately result in cellular proliferation, while inhibiting cellular differentiation, and account for the myriad of physiological outcomes observed during infection with toxinogenic strains of P. multocida.
authors.affiliation: Department of Microbiology and the Host-Microbe Systems Theme of the Institute for Genomic Biology, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. bawilson@life.illinois.edu
authors.forename: Brenda A
authors.initials: BA
authors.lastname: Wilson
authors.forename: Mengfei
authors.initials: M
authors.lastname: Ho
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D001427:Bacterial Toxins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D020962:Heterotrimeric GTP-Binding Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D054884:Host-Pathogen Interactions; D006801:Humans; D010326:Pasteurella Infections / Q000235:genetics / Q000378:metabolism* / Q000382:microbiology; D016979:Pasteurella multocida / Q000235:genetics* / Q000378:metabolism; D017434:Protein Structure, Tertiary; D021122:Protein Subunits; D021381:Protein Transport; D015398:Signal Transduction; D015854:Up-Regulation
chemical_list: D001426:Bacterial Proteins; D001427:Bacterial Toxins; C062258:Pasteurella multocida toxin; D021122:Protein Subunits; D020962:Heterotrimeric GTP-Binding Proteins