title: Involvement of 5-HT₇ receptors in the pathogenesis of temporal lobe epilepsy.
abstract: The 5-hydroxytryptamine 7 (5-HT(7)) receptor is the most recently classified member of the serotonin receptor family. The localization of 5-HT(7) receptors and the biological activity of its ligands have suggested that 5-HT(7) receptors might be involved in the pathogenesis of epilepsy. In the present study, we investigated the correlation between temporal lobe epilepsy and 5-HT(7) receptors using pilocarpine-induced rat models of temporal lobe epilepsy and surgical samples of temporal neocortex from intractable epilepsy patients. An analysis of electroencephalogram (EEG) and behavioral changes before and after the treatment of SB269970 hydrochloride (a selective 5-HT(7) receptor antagonist, 10 mg/kg, i.p.) and AS19 (a selective 5-HT(7) receptor agonist, 10 mg/kg, s.c.) demonstrated that in epileptic rats the activation of 5-HT(7) receptors could increase the number of seizures, which could be reduced by a 5-HT(7) receptor antagonist. Moreover, the expression of 5-HT(7) receptors was higher in the epilepsy group compared with the nonepileptic group in both rat and human brain tissues. The present results suggested that 5-HT(7) receptors participate in the pathogenesis of temporal lobe epilepsy, and a 5-HT(7) receptor antagonist may be used as a therapeutic alternative for temporal lobe epilepsy.
authors.affiliation: Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
authors.forename: Zhiyong
authors.initials: Z
authors.lastname: Yang
authors.forename: Xijin
authors.initials: X
authors.lastname: Liu
authors.forename: Yaping
authors.initials: Y
authors.lastname: Yin
authors.forename: Shenggang
authors.initials: S
authors.lastname: Sun
authors.forename: Xuejun
authors.initials: X
authors.lastname: Deng
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002648:Child; D004195:Disease Models, Animal; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019579:Neocortex / Q000503:physiopathology; D010636:Phenols / Q000494:pharmacology; D010862:Pilocarpine; D011720:Pyrazoles / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D011985:Receptors, Serotonin / Q000187:drug effects / Q000378:metabolism*; D012702:Serotonin Antagonists / Q000494:pharmacology; D017366:Serotonin Receptor Agonists / Q000494:pharmacology; D013449:Sulfonamides / Q000494:pharmacology; D013702:Temporal Lobe / Q000187:drug effects / Q000503:physiopathology; D013764:Tetrahydronaphthalenes / Q000494:pharmacology; D055815:Young Adult
chemical_list: C505862:AS 19 compound; D010636:Phenols; D011720:Pyrazoles; D011985:Receptors, Serotonin; C404922:SB 269970; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; D013449:Sulfonamides; D013764:Tetrahydronaphthalenes; C104425:serotonin 7 receptor; D010862:Pilocarpine