title: Isolation and characterization of a novel recombinant human adenovirus species D.
abstract: A novel recombinant human adenovirus (HAdV) species D was isolated from the stool of a pharyngitis patient in Japan and genetic characterization was performed by sequencing variable regions between HAdV types. The nucleotide sequences of the penton base gene and loops 1 and 2 in the hexon gene showed 100% identity with that of the recently identified HAdV-56. Although we observed greatest identity for the entire hexon gene sequence with that of HAdV-56, we noted even greater similarity between the partial nucleotide sequence of the conserved region 4 and that of HAdV-37. Furthermore, the fibre gene and early region 3 sequences were completely identical to that of HAdV-37. These results suggest that the strain is a novel adenovirus related to HAdV-37 and HAdV-56.
authors.affiliation: Department of Infectious Diseases, Osaka Prefectural Institute of Public Health, Osaka, Japan.
authors.forename: Satoshi
authors.initials: S
authors.lastname: Hiroi
authors.affiliation: Department of Pediatrics, Matsushita Memorial Hospital, Osaka, Japan.
authors.forename: Moriatsu
authors.initials: M
authors.lastname: Izumi
authors.affiliation: Department of Infectious Diseases, Osaka Prefectural Institute of Public Health, Osaka, Japan.
authors.forename: Kazuo
authors.initials: K
authors.lastname: Takahashi
authors.affiliation: Department of Infectious Diseases, Osaka Prefectural Institute of Public Health, Osaka, Japan.
authors.forename: Saeko
authors.initials: S
authors.lastname: Morikawa
authors.affiliation: Department of Infectious Diseases, Osaka Prefectural Institute of Public Health, Osaka, Japan.
authors.forename: Tetsuo
authors.initials: T
authors.lastname: Kase
mesh_terms: D000258:Adenovirus Infections, Human / Q000821:virology*; D000260:Adenoviruses, Human / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification*; D004279:DNA, Viral / Q000737:chemistry / Q000235:genetics; D005243:Feces / Q000821:virology; D005838:Genotype; D006801:Humans; D007223:Infant; D007564:Japan; D008969:Molecular Sequence Data; D010612:Pharyngitis / Q000821:virology; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA; D014764:Viral Proteins / Q000235:genetics
chemical_list: D004279:DNA, Viral; D014764:Viral Proteins