title: Attenuated sensory deprivation-induced changes of parvalbumin neuron density in the barrel cortex of FcγRllB-deficient mice.
abstract: Recent studies have demonstrated the important role of immune molecules in the development of neuronal circuitry and synaptic plasticity. We have detected the presence of FcγRllB protein in parvalbumin-containing inhibitory interneurons (PV neurons). In the present study, we examined the appearance of PV neurons in the barrel cortex and the effect of sensory deprivation in FcγRllB-deficient mice (FcγRllB-/-) and wild-type mice. There was no substantial difference in the appearance of PV neurons in the developing barrel cortex between FcγRllB-/- and wild-type mice. Sensory deprivation from immediately after birth (P0) or P7 to P12-P14 induced an increase in PV neurons. In contrast, sensory deprivation from P7 or P14 to P28, but not from P21 to P28, decreased PV neurons in wild-type mice. However, sensory deprivation from P0 or P7 to P12-P14 did not increase PV neurons and sensory deprivation from P7 or P14 to P28 did not decrease or only modestly decreased PV neurons in FcγRllB-/- mice. The results indicate that expression of PV is regulated by sensory experience and the second and third postnatal weeks are a sensitive period for sensory deprivation, and suggest that FcγRllB contributes to sensory experience-regulated expression of PV.
authors.affiliation: Department of Medical Technology, Graduate School of Health Sciences, Okayama University, Japan.
authors.forename: Makiko
authors.initials: M
authors.lastname: Watanabe
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Ueno
authors.forename: Shunsuke
authors.initials: S
authors.lastname: Suemitsu
authors.forename: Eriko
authors.initials: E
authors.lastname: Yokobayashi
authors.forename: Yosuke
authors.initials: Y
authors.lastname: Matsumoto
authors.forename: Shinichi
authors.initials: S
authors.lastname: Usui
authors.forename: Hiroko
authors.initials: H
authors.lastname: Sujiura
authors.forename: Motoi
authors.initials: M
authors.lastname: Okamoto
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002540:Cerebral Cortex / Q000378:metabolism*; D007141:Immunoglobulin Fc Fragments / Q000378:metabolism*; D007142:Immunoglobulin gamma-Chains / Q000378:metabolism*; D007150:Immunohistochemistry; D007395:Interneurons / Q000378:metabolism* / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D009474:Neurons / Q000166:cytology* / Q000502:physiology; D010320:Parvalbumins / Q000378:metabolism*; D012683:Sensory Deprivation / Q000502:physiology*
chemical_list: D007141:Immunoglobulin Fc Fragments; D007142:Immunoglobulin gamma-Chains; D010320:Parvalbumins