title: [Role and function regulation of transcription factors in endochondral ossification].
abstract: Endochondral ossification plays critical roles in skeletal development and tissue patterning. Disruption of endochondral ossification and cartilage homeostasis results in skeletal dysplasia and cartilage diseases such as osteoarthritis. Several transcription factors regulate chondrocyte differentiation and expression of chondrogenic matrices, and consequently maintains order of endochondral ossification. In this review article, we would like to introduce recent advancement in understanding of role and functional regulation of transcription factors in endochondral ossification.
authors.affiliation: Department of Molecular and Cellular Biochemistry Osaka University Graduate School of Dentistry, Japan.
authors.forename: Riko
authors.initials: R
authors.lastname: Nishimura
authors.forename: Kenji
authors.initials: K
authors.lastname: Hata
authors.forename: Rikako
authors.initials: R
authors.lastname: Takashima
authors.forename: Michiko
authors.initials: M
authors.lastname: Yoshida
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D019902:Chondrocytes / Q000166:cytology / Q000502:physiology; D020219:Chondrogenesis / Q000502:physiology*; D006801:Humans; D010012:Osteogenesis; D014157:Transcription Factors / Q000502:physiology*
chemical_list: D014157:Transcription Factors