title: Facile preparation of amine and amino acid adducts of [60]fullerene using chlorofullerene C60Cl6 as a precursor.
abstract: We report a general synthetic approach to the preparation of highly functionalized amine and amino acid derivatives of [60]fullerene starting from readily available chlorofullerene C(60)Cl(6). The synthesized water-soluble amino acid derivative of C(60) demonstrated pronounced antiviral activity, while the cationic amine-based compound showed strong antibacterial action in vitro.
authors.affiliation: IPCP RAS, Semenov Prospect 1, Chernogolovka 141432, Russia.
authors.forename: Alexey B
authors.initials: AB
authors.lastname: Kornev
authors.forename: Ekaterina A
authors.initials: EA
authors.lastname: Khakina
authors.forename: Sergey I
authors.initials: SI
authors.lastname: Troyanov
authors.forename: Alla A
authors.initials: AA
authors.lastname: Kushch
authors.forename: Alexander
authors.initials: A
authors.lastname: Peregudov
authors.forename: Alexey
authors.initials: A
authors.lastname: Vasilchenko
authors.forename: Dmitry G
authors.initials: DG
authors.lastname: Deryabin
authors.forename: Vyacheslav M
authors.initials: VM
authors.lastname: Martynenko
authors.forename: Pavel A
authors.initials: PA
authors.lastname: Troshin
mesh_terms: D000588:Amines / Q000737:chemistry*; D000596:Amino Acids / Q000737:chemistry*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects / Q000254:growth & development; D002412:Cations; D002522:Chlorocebus aethiops; D018360:Crystallography, X-Ray; D003587:Cytomegalovirus / Q000187:drug effects / Q000502:physiology; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development; D005347:Fibroblasts / Q000187:drug effects / Q000821:virology; D037741:Fullerenes / Q000737:chemistry*; D006801:Humans; D007274:Injections, Intraperitoneal; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D018139:Simplexvirus / Q000187:drug effects / Q000502:physiology; D014709:Vero Cells / Q000187:drug effects / Q000821:virology
chemical_list: D000588:Amines; D000596:Amino Acids; D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D002412:Cations; D037741:Fullerenes; C069837:fullerene C60