title: POLI-mix functional food enhances steady-state bioenergetic status independently of age: an experimental study.
abstract: BALB/c mice were divided into young, middle-aged, and aged groups, and each group was given 3 weeks of oral treatments: (1) 1 mL of VBC1-99 (a mixture of 42 fruits and vegetables extracts) or (2) 1 mL of same amount of antioxidant vitamins as control. Steady-state hepatic adenosine triphosphate (ATP) was assessed by phosphorus-31 nuclear magnetic resonance ((31)P-NMR) spectroscopy as: β-ATP/reference peak, inorganic phosphorus (Pi)/peak and β-ATP/Pi. As compared to untreated control, VBC1-99 significantly enhanced β-ATP/peak and β-ATP/Pi ratios (p<0.01) in all age groups and throughout the observation period (p<0.05) together with a significant decrease of Pi/ref peak ratio (p<0.05). However, this value in middle-aged and aged mice was comparable to antioxidant control mice. These NMR data demonstrate that VBC1-99 has a beneficial effect on hepatic energy metabolism, irrespective of age.
authors.affiliation: Department of Clinical Nutrition & Dietetics, Shahid Beheshti University of Medical Sciences, National Nutrition and Food Technology Research Institute, Teheran, Iran.
authors.forename: Reza
authors.initials: R
authors.lastname: Rastmanesh
authors.forename: Francesco
authors.initials: F
authors.lastname: Marotta
authors.forename: Makoto Keiichi
authors.initials: MK
authors.lastname: Kantah
authors.forename: Ravinder
authors.initials: R
authors.lastname: Nagpal
authors.forename: Aldo
authors.initials: A
authors.lastname: Lorenzetti
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Takadanohara
authors.forename: Hiroshi
authors.initials: H
authors.lastname: Mashizume
authors.forename: Riyichi
authors.initials: R
authors.lastname: Kobayashi
authors.forename: De Hua
authors.initials: de H
authors.lastname: Chui
mesh_terms: D000255:Adenosine Triphosphate / Q000737:chemistry / Q000378:metabolism; D000284:Administration, Oral; D000375:Aging; D000818:Animals; D004734:Energy Metabolism; D005638:Fruit; D055951:Functional Food; D006863:Hydrogen-Ion Concentration; D008099:Liver / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D051379:Mice; D008807:Mice, Inbred BALB C; D018384:Oxidative Stress; D010766:Phosphorylation; D010936:Plant Extracts / Q000494:pharmacology; D013997:Time Factors; D014675:Vegetables
chemical_list: D010936:Plant Extracts; D000255:Adenosine Triphosphate