title: Genome sequencing and cancer.
abstract: New technologies for DNA sequencing, coupled with advanced analytical approaches, are now providing unprecedented speed and precision in decoding human genomes. This combination of technology and analysis, when applied to the study of cancer genomes, is revealing specific and novel information about the fundamental genetic mechanisms that underlie cancer's development and progression. This review outlines the history of the past several years of development in this realm, and discusses the current and future applications that will further elucidate cancer's genomic causes.
authors.affiliation: The Genome Institute at Washington University School of Medicine, St. Louis, MO 63108, United States. emardis@wustl.edu
authors.forename: Elaine R
authors.initials: ER
authors.lastname: Mardis
mesh_terms: D002877:Chromosomes, Human / Q000235:genetics* / Q000378:metabolism; D004273:DNA, Neoplasm / Q000032:analysis* / Q000235:genetics; D018450:Disease Progression; D052138:Genes, Neoplasm; D005820:Genetic Testing / Q000379:methods; D015894:Genome, Human; D023281:Genomics / Q000379:methods; D006801:Humans; D053208:Kaplan-Meier Estimate; D009154:Mutation; D009362:Neoplasm Metastasis / Q000235:genetics; D009369:Neoplasms / Q000175:diagnosis / Q000235:genetics*; D017422:Sequence Analysis, DNA / Q000379:methods*
chemical_list: D004273:DNA, Neoplasm