title: Ultrasensitive detection of potassium ions based on target induced DNA conformational switch enhanced fluorescence polarization.
abstract: We have developed a simple, highly sensitive and selective fluorescence polarization assay for the detection of potassium ions based on target induced DNA conformational switch from hairpin to G-quadruplex enhanced fluorescence polarization. The assay was applied in the detection of low nM concentrations of potassium ions and was highly selective over other cations.
authors.affiliation: Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources (Ministry of Education), College of Chemistry and Chemical Engineering, Guangxi Normal University, Guilin, 541004, China. hukun216@163.com
authors.forename: Kun
authors.initials: K
authors.lastname: Hu
authors.forename: Yong
authors.initials: Y
authors.lastname: Huang
authors.forename: Shulin
authors.initials: S
authors.lastname: Zhao
authors.forename: Jianniao
authors.initials: J
authors.lastname: Tian
authors.forename: Qiang
authors.initials: Q
authors.lastname: Wu
authors.forename: Guohai
authors.initials: G
authors.lastname: Zhang
authors.forename: Jing
authors.initials: J
authors.lastname: Jiang
mesh_terms: D001483:Base Sequence; D015374:Biosensing Techniques / Q000379:methods*; D004247:DNA / Q000737:chemistry*; D005454:Fluorescence Polarization; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D015345:Oligonucleotide Probes / Q000737:chemistry / Q000235:genetics; D011188:Potassium / Q000032:analysis* / Q000737:chemistry*
chemical_list: D015345:Oligonucleotide Probes; D004247:DNA; D011188:Potassium