title: The impact of pretransplant 25-hydroxy vitamin D deficiency on subsequent graft function: an observational study.
abstract: BACKGROUND
  In addition to its canonical role in musculoskeletal health, several reports have demonstrated that serum vitamin D level may influence kidney function. However, the effect of pretransplant serum vitamin D level on subsequent graft function has not been explored. Therefore, this study was undertaken to examine the effect of serum vitamin D level at the time of kidney transplantation (KT) on subsequent graft function.
  
  
  METHODS
  We analyzed 106 patients who underwent KT and for whom 25-hydroxy vitamin D (25-OHD) levels were measured during hospitalization prior to transplantation. We measured estimated glomerular filtration rates (eGFR) using the Modification of Diet in Renal Disease (MDRD) formula at baseline and at six-month intervals up to 36 months after KT.
  
  
  RESULTS
  38.7% of the patients were diagnosed with 25-OHD deficiency defined as less than 10 ng/mL. Recipient gender (female vs. male, odds ratio [OR] 3.30, 95% CI 1.33-8.21, P=0.010), serum albumin level (per 1 mg/dl increase, OR 0.35, 95% CI 0.13-0.98, P=0.047), and predominant renal replacement therapy modality before KT (P<0.001) were found to be independent pretransplant risk factors for 25-OHD deficiency by multivariate logistic regression analysis. Subsequent repeated measures analysis of covariance revealed that 25-OHD level had the only significant main effect on eGFR during the 36-month follow-up period [F (1, 88)=12.07, P=0.001].
  
  
  CONCLUSIONS
  Pretransplant 25-OHD deficiency was significantly associated with a lower post-transplant eGFR, suggesting that 25-OHD may play an important role in maintaining graft function after KT.
authors.affiliation: Department of Internal Medicine, Wonkwang University College of Medicine, Sanbon Hospital, Kyunggi-do, Korea.
authors.forename: Hyunwook
authors.initials: H
authors.lastname: Kim
authors.forename: Shin-Wook
authors.initials: SW
authors.lastname: Kang
authors.forename: Tae-Hyun
authors.initials: TH
authors.lastname: Yoo
authors.forename: Myoung Soo
authors.initials: MS
authors.lastname: Kim
authors.forename: Soon Il
authors.initials: SI
authors.lastname: Kim
authors.forename: Yu Seun
authors.initials: YS
authors.lastname: Kim
authors.forename: Kyu Hun
authors.initials: KH
authors.lastname: Choi
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D016001:Confidence Intervals; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D016030:Kidney Transplantation / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D011184:Postoperative Period; D057234:Preoperative Period; D017582:Renal Replacement Therapy / Q000009:adverse effects; D056910:Republic of Korea; D012621:Seasons; D012709:Serum Albumin / Q000378:metabolism; D012737:Sex Factors; D013472:Sunlight; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood; D014808:Vitamin D Deficiency / Q000150:complications* / Q000209:etiology; D055815:Young Adult
chemical_list: D012709:Serum Albumin; D014807:Vitamin D; C104450:25-hydroxyvitamin D