title: New hexadentate macrocyclic ligand and their copper(II) and nickel(II) complexes: Spectral, magnetic, electrochemical, thermal, molecular modeling and antimicrobial studies.
abstract: Ni(II) and Cu(II) complexes were synthesized with a hexadentate macrocyclic ligand [3,4,8,9tetraoxo-2,5,7,10tetraaza-1,6dithio-(3,4,8,9) dipyridinedodecane(L)] and characterized by elemental analysis, molar conductance measurements, mass, NMR, IR, electronic, EPR spectral, thermal and molecular modeling studies. All the complexes are 1:2 electrolytes in nature and may be formulated as [M(L)]X(2) [where, M=Ni(II) and Cu(II) and X=Cl(-), NO(3)(-), ½SO(4)(2-), CH(3)COO(-)]. On the basis of IR, electronic and EPR spectral studies an octahedral geometry has been assigned for Ni(II) complexes and tetragonal geometry for Cu(II) complexes. The antimicrobial activities and LD(50) values of the ligand and its complexes, as growth inhibiting agents, have been screened in vitro against two different species of bacteria and plant pathogenic fungi.
authors.affiliation: Department of Chemistry, Zakir Husain College, University of Delhi, J.L. Nehru Marg, New Delhi 110002, India. schandra_00@yahoo.com
authors.forename: Sulekh
authors.initials: S
authors.lastname: Chandra
authors.lastname: Ruchi
authors.forename: Kushal
authors.initials: K
authors.lastname: Qanungo
authors.forename: Saroj K
authors.initials: SK
authors.lastname: Sharma
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D056831:Coordination Complexes / Q000737:chemistry* / Q000494:pharmacology; D003300:Copper / Q000737:chemistry / Q000494:pharmacology; D055664:Electrochemical Techniques / Q000379:methods*; D004578:Electron Spin Resonance Spectroscopy; D004583:Electrons; D005658:Fungi / Q000187:drug effects; D008024:Ligands; D047028:Macrocyclic Compounds / Q000737:chemistry* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D008958:Models, Molecular; D009532:Nickel / Q000737:chemistry / Q000494:pharmacology; D009584:Nitrogen / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D055672:Static Electricity; D013696:Temperature; D014961:X-Ray Diffraction; D016959:Xanthomonas campestris / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D056831:Coordination Complexes; D008024:Ligands; D047028:Macrocyclic Compounds; D003300:Copper; D009532:Nickel; D009584:Nitrogen