title: [Disturbances of immune status and cytokine profile caused by chronic intoxication with organophosphorus compounds and their correction by administration of imunofan].
abstract: Experiments on noninbred rats showed that the chronic intoxication with organophosphorus compounds sarin and methylparathion (30 days; total dose, 0.9 LD50; single daily dose, 0.03 mg/kg,) significantly decreases the immune responses and reduces the concentrations of blood cytokines IFN-gamma, IL-2, IL-4, IL-6, and IL-10. The damage is more pronounced in Th1 cells than in Th2 lymphocytes. The administration of imunofan (single daily dose, 20 microg/kg) for 5 days partly recovers the immune status and the content of cytokines in the blood.
authors.forename: P F
authors.initials: PF
authors.lastname: Zabrodskiĭ
authors.forename: V G
authors.initials: VG
authors.lastname: Lim
authors.forename: E V
authors.initials: EV
authors.lastname: Strel'tsova
mesh_terms: D000818:Animals; D002800:Cholinesterase Inhibitors / Q000633:toxicity; D005260:Female; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007113:Immunity, Innate / Q000187:drug effects*; D007155:Immunologic Factors / Q000008:administration & dosage* / Q000627:therapeutic use; D007273:Injections, Intramuscular; D007279:Injections, Subcutaneous; D007371:Interferon-gamma / Q000097:blood; D016753:Interleukin-10 / Q000097:blood; D007376:Interleukin-2 / Q000097:blood; D015847:Interleukin-4 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D008743:Methyl Parathion / Q000633:toxicity*; D009842:Oligopeptides / Q000008:administration & dosage* / Q000627:therapeutic use; D051381:Rats; D012524:Sarin / Q000633:toxicity*; D018417:Th1 Cells / Q000166:cytology / Q000187:drug effects* / Q000276:immunology; D018418:Th2 Cells / Q000166:cytology / Q000187:drug effects / Q000276:immunology
chemical_list: D002800:Cholinesterase Inhibitors; D007155:Immunologic Factors; D007376:Interleukin-2; D015850:Interleukin-6; D009842:Oligopeptides; C080035:thymohexin; D016753:Interleukin-10; D015847:Interleukin-4; D008743:Methyl Parathion; D007371:Interferon-gamma; D012524:Sarin