title: Elemental imaging of MRI contrast agents: benchmarking of LA-ICP-MS to MRI.
abstract: Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) has been used to map the spatial distribution of magnetic resonance imaging (MRI) contrast agents (Gd-based) in histological sections in order to explore synergies with in vivo MRI. Images from respective techniques are presented for two separate studies namely (1) convection enhanced delivery of a Gd nanocomplex (developmental therapeutic) into rat brain and (2) convection enhanced delivery, with co-infusion of Magnevist (commercial Gd contrast agent) and Carboplatin (chemotherapy drug), into pig brain. The LA technique was shown to be a powerful compliment to MRI not only in offering improved sensitivity, spatial resolution and signal quantitation but also in giving added value regarding the fate of administered agents (Gd and Pt agents). Furthermore simultaneous measurement of Fe enabled assignment of an anomalous contrast enhancement region in rat brain to haemorrhage at the infusion site.
authors.affiliation: Centre for Analytical Sciences, University of Sheffield, Dainton Building, Sheffield, S3 7HF, UK.
authors.forename: J A T
authors.initials: JA
authors.lastname: Pugh
authors.forename: A G
authors.initials: AG
authors.lastname: Cox
authors.forename: C W
authors.initials: CW
authors.lastname: McLeod
authors.forename: J
authors.initials: J
authors.lastname: Bunch
authors.forename: M J
authors.initials: MJ
authors.lastname: Writer
authors.forename: S L
authors.initials: SL
authors.lastname: Hart
authors.forename: A
authors.initials: A
authors.lastname: Bienemann
authors.forename: E
authors.initials: E
authors.lastname: White
authors.forename: J
authors.initials: J
authors.lastname: Bell
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D016190:Carboplatin / Q000008:administration & dosage; D003287:Contrast Media; D019786:Gadolinium DTPA / Q000008:administration & dosage; D008081:Liposomes; D008279:Magnetic Resonance Imaging / Q000379:methods*; D053758:Nanoparticles; D051381:Rats; D013552:Swine
chemical_list: D003287:Contrast Media; D008081:Liposomes; D016190:Carboplatin; D019786:Gadolinium DTPA