title: Is human papilloma virus associated with salivary gland neoplasms? An in situ-hybridization study.
abstract: OBJECTIVE
  HPV can infect cells of epithelial origin and is closely associated with carcinomas. Studies investigating its presence in salivary gland neoplasms are few and conflicting.
  
  
  METHODS
  Detection of HPV types 16 & 18 was done on 34 formalin-fixed, paraffin-embedded archival material of different salivary gland neoplasms using Digene HPV types 16 & 18 probe using in situ hybridization technique.
  
  
  RESULTS
  Eight of neoplastic salivary gland specimens were positively infected by HPV types 16 & 18. Seven of them were benign (4 Warthin's tumour, 2 pleomorphic adenoma and one myoepithelioma), in addition to one malignant specimen (lymphoma). Correlation was found between the incidence of HPV infection and histological differentiation of salivary gland neoplasms.
  
  
  CONCLUSIONS
  An association exists between HPV infections and salivary gland neoplasms. However, given the sparse pattern of reactive cells, it cannot be confirmed that this virus is implicated in the aetiology of this group of tumours.
authors.affiliation: Oral Pathology Department, Faculty of Oral and Dental Medicine, Cairo University, Mathaf-El-Manial Street, El-Manial, Cairo, Egypt.
authors.forename: Layla
authors.initials: L
authors.lastname: Hafed
authors.forename: Heba
authors.initials: H
authors.lastname: Farag
authors.forename: Olfat
authors.initials: O
authors.lastname: Shaker
authors.forename: Dalia
authors.initials: D
authors.lastname: El-Rouby
mesh_terms: D000235:Adenolymphoma / Q000821:virology; D008949:Adenoma, Pleomorphic / Q000821:virology; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003528:Carcinoma, Adenoid Cystic / Q000821:virology; D018277:Carcinoma, Mucoepidermoid / Q000821:virology; D015342:DNA Probes; D004279:DNA, Viral / Q000032:analysis; D004847:Epithelial Cells / Q000821:virology; D005260:Female; D052162:Human papillomavirus 16 / Q000302:isolation & purification*; D052161:Human papillomavirus 18 / Q000302:isolation & purification*; D006801:Humans; D017403:In Situ Hybridization; D008223:Lymphoma / Q000821:virology; D008297:Male; D008875:Middle Aged; D009208:Myoepithelioma / Q000821:virology; D030361:Papillomavirus Infections / Q000821:virology*; D012468:Salivary Gland Neoplasms / Q000821:virology*; D055815:Young Adult
chemical_list: D015342:DNA Probes; D004279:DNA, Viral