title: Non-alcoholic fatty liver disease in children.
abstract: Non-alcoholic fatty liver disease is increasingly prevalent in children, together with obesity. Transaminases, tests for insulin resistance, ultrasonography and MRI are variably used as surrogates markers of steatosis. Other liver diseases, such as Wilson disease, should be excluded. A liver biopsy is performed in selected cases: young children, familial history of severe disease, inconclusive tests for other pathologies, suspected advanced fibrosis, hypertransaminasemia despite weight loss and in clinical trials. Weight reduction, and changes in lifestyle, are the front-line treatment. Drug therapy is under evaluation.
authors.affiliation: Department of Gastroenterology, Hepatology and Eating Disorders, The Children's Memorial Health Institute, Warsaw, Poland. w.janczyk@czd.pl
authors.forename: Wojciech
authors.initials: W
authors.lastname: Janczyk
authors.forename: Piotr
authors.initials: P
authors.lastname: Socha
mesh_terms: D001706:Biopsy; D002648:Child; D005234:Fatty Liver / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D008019:Life Style; D008099:Liver / Q000473:pathology; D008687:Metformin / Q000627:therapeutic use; D009765:Obesity / Q000503:physiopathology; D000077205:Pioglitazone; D045162:Thiazolidinediones / Q000627:therapeutic use; D000637:Transaminases / Q000097:blood; D015431:Weight Loss
chemical_list: D007004:Hypoglycemic Agents; D045162:Thiazolidinediones; D008687:Metformin; D000637:Transaminases; D000077205:Pioglitazone