title: Adaptation of human and simian immunodeficiency viruses for resistance to tetherin/BST-2.
abstract: Tetherin (BST-2 or CD317) is an interferon-inducible cellular factor that prevents the detachment of enveloped viruses from infected cells. The primate lentiviruses have evolved different countermeasures to tetherin. The majority of SIVs use Nef to antagonize the tetherin proteins of their nonhuman primate hosts. However, due to the absence of sequences in human tetherin required for antagonism by Nef, HIV-1 Vpu and HIV-2 Env evolved to serve this function in humans. We recently identified compensatory changes in the Env cytoplasmic domain of a pathogenic nef-deleted SIV that confers resistance to rhesus macaque tetherin. These observations highlight the extraordinary plasticity of the primate lentiviruses in adapting to the tetherin proteins of their respective hosts, and reveal a prominent role for tetherin in shaping the evolution of the primate lentiviruses.
authors.affiliation: New England Primate Research Center, Harvard Medical School, Southborough, MA 01772, USA.
authors.forename: Ruth
authors.initials: R
authors.lastname: Serra-Moreno
authors.forename: David T
authors.initials: DT
authors.lastname: Evans
mesh_terms: D000220:Adaptation, Biological; D000595:Amino Acid Sequence; D000818:Animals; D015703:Antigens, CD; D000998:Antiviral Agents / Q000494:pharmacology*; D015496:CD4-Positive T-Lymphocytes; D024882:Drug Resistance, Viral / Q000235:genetics*; D058851:GPI-Linked Proteins / Q000037:antagonists & inhibitors; D015497:HIV-1 / Q000235:genetics*; D015498:HIV-2 / Q000235:genetics*; D054884:Host-Pathogen Interactions; D054298:Human Immunodeficiency Virus Proteins / Q000235:genetics; D006801:Humans; D007372:Interferons / Q000494:pharmacology*; D008253:Macaca mulatta; D008969:Molecular Sequence Data; D002679:Pan troglodytes; D010802:Phylogeny; D015302:Simian Immunodeficiency Virus / Q000235:genetics* / Q000276:immunology; D013045:Species Specificity; D054334:Viral Regulatory and Accessory Proteins / Q000235:genetics; D054299:env Gene Products, Human Immunodeficiency Virus / Q000235:genetics; D054311:nef Gene Products, Human Immunodeficiency Virus / Q000235:genetics; D000074010:Bone Marrow Stromal Antigen 2; D000086082:Viroporin Proteins
chemical_list: D015703:Antigens, CD; D000998:Antiviral Agents; D058851:GPI-Linked Proteins; D054298:Human Immunodeficiency Virus Proteins; D007372:Interferons; D054334:Viral Regulatory and Accessory Proteins; D054299:env Gene Products, Human Immunodeficiency Virus; D054311:nef Gene Products, Human Immunodeficiency Virus; C094572:BST2 protein, human; D000074010:Bone Marrow Stromal Antigen 2; C429284:NEF protein, SIV; C514859:vpu protein, Human immunodeficiency virus 1; D000086082:Viroporin Proteins