title: Association of outer retinal layer morphology with visual acuity in patients with retinal vein occlusion: SCORE Study Report 13.
abstract: OBJECTIVE
  To assess associations between visual acuity (VA) and the status of the photoreceptor inner segment-outer segment (IS-OS) junction in a subset of patients in the Standard Care vs COrticosteroid for REtinal Vein Occlusion (SCORE) Study.
  
  
  METHODS
  High-resolution time domain optical coherence tomography (OCT) scans of study eyes from a single site participating in the SCORE Study were evaluated. Integrity of the IS-OS junction in the central subfield was evaluated using a three-step scale: absent, abnormal or normal. Associations of the IS-OS status with ETDRS VA letter score and center point thickness (CPT) were investigated.
  
  
  RESULTS
  Baseline OCTs of 42 eyes were evaluated. The IS-OS junction was absent in 30 (71%) and abnormal in 12 (29%). At month 12, the IS-OS junction was absent in 18 (43%), abnormal in 12 (28%), and normal in 12 (28%) eyes. At baseline, IS-OS status was significantly associated with CPT, but not with VA. At month 12, IS-OS status was significantly associated with CPT and VA, that is, absent or abnormal IS-OS was associated with increased CPT and worse VA. Change in IS-OS status was not associated with change in CPT (P=0.8). Worsening of IS-OS status was associated with loss of VA and improvement in IS-OS status to normal was associated with gain in VA (P=0.03).
  
  
  CONCLUSIONS
  In this data set with long-term follow-up of OCTs as part of the SCORE Study, there is a correlation between change in IS-OS status and VA. This supports further evaluation of outer retinal morphology in larger data sets.
authors.affiliation: Fundus Photograph Reading Center, University of Wisconsin, Madison, WI 53717, USA.
authors.forename: A
authors.initials: A
authors.lastname: Domalpally
authors.forename: Q
authors.initials: Q
authors.lastname: Peng
authors.forename: R
authors.initials: R
authors.lastname: Danis
authors.forename: B
authors.initials: B
authors.lastname: Blodi
authors.forename: I U
authors.initials: IU
authors.lastname: Scott
authors.forename: M
authors.initials: M
authors.lastname: Ip
mesh_terms: D015331:Cohort Studies; D006801:Humans; D055211:Retinal Photoreceptor Cell Inner Segment / Q000473:pathology* / Q000502:physiology; D055214:Retinal Photoreceptor Cell Outer Segment / Q000473:pathology* / Q000502:physiology; D012170:Retinal Vein Occlusion / Q000503:physiopathology*; D041623:Tomography, Optical Coherence / Q000379:methods; D014792:Visual Acuity / Q000502:physiology*