title: A general solid phase method for the synthesis of sequence independent peptidyl-fluoromethyl ketones.
abstract: We present here a new, general, solid phase strategy for the synthesis of sequence independent peptidyl-fluoromethyl ketones using standard Fmoc peptide chemistry. Our method is based on the synthesis of bifunctional linkers which allows the incorporation of amino acid fluoromethyl ketone unit at the C-terminal end of peptide sequences. Application of this approach for the synthesis of activity based probes for SENPs is also described.
authors.affiliation: Department of Chemistry, Marie Curie Excellence Team, Technical University München, 4 Lichtenberg str. 85748, Garching, Germany.
authors.forename: Gheorghe-Doru
authors.initials: GD
authors.lastname: Roiban
authors.forename: Mihaela
authors.initials: M
authors.lastname: Matache
authors.forename: Niculina D
authors.initials: ND
authors.lastname: Hădade
authors.forename: Daniel P
authors.initials: DP
authors.lastname: Funeriu
mesh_terms: D017611:Fluorine Compounds / Q000138:chemical synthesis*; D007659:Ketones / Q000138:chemical synthesis*; D008745:Methylation; D015394:Molecular Structure; D010455:Peptides / Q000737:chemistry*
chemical_list: D017611:Fluorine Compounds; D007659:Ketones; D010455:Peptides