title: Oxidative stress biomarkers in patients with untreated obstructive sleep apnea syndrome.
abstract: BACKGROUND
  The pathogenic role of oxidative stress in obstructive sleep apnea syndrome (OSAS) is still a matter of debate, with different studies obtaining contrasting results.
  
  
  METHODS
  The aim of the present study was to evaluate three well-known markers of oxidative stress (advanced oxidation protein products [AOPP], ferric reducing antioxidant power [FRAP], and total glutathione [GSH]) in a cohort of 41 untreated patients with a new diagnosis of OSAS.
  
  
  RESULTS
  We observed that OSAS patients showed increased protein oxidative damage and impaired antioxidant defenses. Patients with more severe OSAS had a lower total antioxidant capability. Preliminary data on a subgroup of patients (n=7) treated with CPAP show a significant increment of the FRAP values (P<0.005).
  
  
  CONCLUSIONS
  Our findings indicate that such oxidative stress markers may be useful to detect and monitor redox imbalance in OSAS. Moreover, FRAP might be a new useful biomarker to monitor in vivo the oxidative response to CPAP therapy.
authors.affiliation: Department of Neuroscience, Neurological Clinic, University of Pisa, Via Roma 67, 56126 Pisa, Italy. mancusomichelangelo@gmail.com
authors.forename: Michelangelo
authors.initials: M
authors.lastname: Mancuso
authors.forename: Enrica
authors.initials: E
authors.lastname: Bonanni
authors.forename: Annalisa
authors.initials: A
authors.lastname: LoGerfo
authors.forename: Daniele
authors.initials: D
authors.lastname: Orsucci
authors.forename: Michelangelo
authors.initials: M
authors.lastname: Maestri
authors.forename: Lucia
authors.initials: L
authors.lastname: Chico
authors.forename: Elisa
authors.initials: E
authors.lastname: DiCoscio
authors.forename: Monica
authors.initials: M
authors.lastname: Fabbrini
authors.forename: Gabriele
authors.initials: G
authors.lastname: Siciliano
authors.forename: Luigi
authors.initials: L
authors.lastname: Murri
mesh_terms: D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000097:blood; D015331:Cohort Studies; D045422:Continuous Positive Airway Pressure; D005260:Female; D005296:Ferrous Compounds / Q000097:blood; D005978:Glutathione / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000502:physiology*; D017286:Polysomnography; D017382:Reactive Oxygen Species / Q000097:blood*; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis / Q000378:metabolism* / Q000628:therapy*
chemical_list: D000975:Antioxidants; D015415:Biomarkers; D005296:Ferrous Compounds; D017382:Reactive Oxygen Species; D005978:Glutathione