title: DNA breakage drives nuclear search.
abstract: The search for a homologous template is a fundamental, yet largely uncharacterized, reaction in DNA double-strand break repair. Two reports now demonstrate that broken chromosomes increase their movement and explore large volumes of nuclear space searching for a homologous template. Break mobility requires resection and recombination enzymes, as well as damage-checkpoint components.
authors.affiliation: Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030, USA. gira@bcm.edu
authors.forename: Grzegorz
authors.initials: G
authors.lastname: Ira
authors.forename: Philip J
authors.initials: PJ
authors.lastname: Hastings
mesh_terms: D018797:Cell Cycle Proteins / Q000502:physiology*; D015825:Chromosomes, Fungal; D004249:DNA Damage; D047908:Intracellular Signaling Peptides and Proteins / Q000502:physiology*; D017346:Protein Serine-Threonine Kinases / Q000502:physiology*; D011995:Recombination, Genetic; D029701:Saccharomyces cerevisiae Proteins / Q000502:physiology*
chemical_list: D018797:Cell Cycle Proteins; D047908:Intracellular Signaling Peptides and Proteins; D029701:Saccharomyces cerevisiae Proteins; C069930:rad9 protein; C088937:MEC1 protein, S cerevisiae; D017346:Protein Serine-Threonine Kinases