title: Photosensitivity syndrome brings to light a new transcription-coupled DNA repair cofactor.
abstract: Three teams have applied whole-exome and proteome methods to identify a new cofactor of human RNA polymerase II that is required for the recovery of transcription on damaged templates. The identification of this new factor raises questions about the causal relationships between molecular mechanisms of transcription regulation and excision repair and developmental and neurological disease and nonmalignant skin photosensitivity.
authors.affiliation: Department of Dermatology, University of California, San Francisco, California, USA. jcleaver@cc.ucsf.edu
authors.forename: James E
authors.initials: JE
authors.lastname: Cleaver
mesh_terms: D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism*; D003057:Cockayne Syndrome / Q000235:genetics*; D004249:DNA Damage / Q000235:genetics*; D004265:DNA Helicases / Q000737:chemistry*; D004260:DNA Repair / Q000235:genetics*; D045643:DNA Repair Enzymes / Q000737:chemistry*; D006801:Humans; D009154:Mutation / Q000235:genetics*; D000075223:Poly-ADP-Ribose Binding Proteins; D055550:Protein Stability / Q000528:radiation effects*; D012319:RNA Polymerase II / Q000235:genetics*; D014158:Transcription, Genetic; D025801:Ubiquitin / Q000378:metabolism*; D043222:Ubiquitin Thiolesterase / Q000378:metabolism*; D000076084:Ubiquitin-Specific Peptidase 7; D014466:Ultraviolet Rays
chemical_list: D002352:Carrier Proteins; D000075223:Poly-ADP-Ribose Binding Proteins; C573137:UVSSA protein, human; D025801:Ubiquitin; D012319:RNA Polymerase II; C464569:USP7 protein, human; D043222:Ubiquitin Thiolesterase; D000076084:Ubiquitin-Specific Peptidase 7; D004265:DNA Helicases; C078673:ERCC6 protein, human; D045643:DNA Repair Enzymes