title: MR neurography of the median nerve at 3.0T: optimization of diffusion tensor imaging and fiber tractography.
abstract: OBJECTIVE
  The purpose of this study was to systematically assess the optimal b-value and reconstruction parameters for DTI and fiber tractography of the median nerve at 3.0T.
  
  
  METHODS
  Local ethical board approved study with 45 healthy volunteers (15 men, 30 women; mean age, 41 ± 3.4 years) who underwent DTI of the right wrist at 3.0T. A single-shot echo-planar-imaging sequence (TR/TE 10123/40 ms) was acquired at four different b-values (800, 1000, 1200, and 1400 s/mm(2)). Two independent readers performed post processing and fiber-tractography. Fractional anisotropy (FA) maps were calculated. Fiber tracts of the median nerve were generated using four different algorithms containing different FA thresholds and different angulation tolerances. Data were evaluated quantitatively and qualitatively.
  
  
  RESULTS
  Tracking algorithms using a minimum FA threshold of 0.2 and a maximum angulation of 10° were significantly better than other algorithms. Fiber tractography generated significantly longer fibers in DTI acquisitions with higher b-values (1200 and 1400 s/mm(2) versus 800 s/mm(2); p<0.001). The overall quality of fiber tractography was best at a b-value of 1200 s/mm(2) (p<0.001).
  
  
  CONCLUSIONS
  In conclusion, our results indicate use of b-values between 1000 and 1400 s/mm(2) for DTI of the median nerve at 3.0T. Optimal reconstruction parameters for fiber tractography should encompass a minimum FA threshold of 0.2 and a maximum angulation tolerance of 10.
authors.affiliation: Department of Radiology, University Hospital Zurich, Ramistrasse 100, CH 8091 Zurich, Switzerland. roman.guggenberger@usz.ch
authors.forename: Roman
authors.initials: R
authors.lastname: Guggenberger
authors.forename: Patrick
authors.initials: P
authors.lastname: Eppenberger
authors.forename: Daniel
authors.initials: D
authors.lastname: Markovic
authors.forename: Daniel
authors.initials: D
authors.lastname: Nanz
authors.forename: Avneesh
authors.initials: A
authors.lastname: Chhabra
authors.forename: Klaas P
authors.initials: KP
authors.lastname: Pruessmann
authors.forename: Gustav
authors.initials: G
authors.lastname: Andreisek
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D016880:Anisotropy; D003430:Cross-Sectional Studies; D056324:Diffusion Tensor Imaging / Q000379:methods*; D017352:Echo-Planar Imaging; D005260:Female; D006801:Humans; D008297:Male; D008475:Median Nerve / Q000033:anatomy & histology*; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000648:ultrastructure*; D009434:Neural Pathways / Q000033:anatomy & histology*; D011446:Prospective Studies