title: Wake promoting agents: search for next generation modafinil, lessons learned: part III.
abstract: In searching for a next generation molecule to the novel wake promoting agent modafinil (compound 1), a series of fluorene-derived wakefulness enhancing agents were developed and evaluated in rat. Extensive pharmacokinetic studies of a potent member of the series (compound 15) revealed that the wake promotion activity of the analog was likely due to an active metabolite (compound 3).
authors.affiliation: Cephalon, Inc., 145 Brandywine Parkway, West Chester, PA 19380-4245, USA.
authors.forename: Derek
authors.initials: D
authors.lastname: Dunn
authors.forename: Greg
authors.initials: G
authors.lastname: Hostetler
authors.forename: Mohamed
authors.initials: M
authors.lastname: Iqbal
authors.forename: Val R
authors.initials: VR
authors.lastname: Marcy
authors.forename: Yin Guo
authors.initials: YG
authors.lastname: Lin
authors.forename: Bruce
authors.initials: B
authors.lastname: Jones
authors.forename: Lisa D
authors.initials: LD
authors.lastname: Aimone
authors.forename: John
authors.initials: J
authors.lastname: Gruner
authors.forename: Mark A
authors.initials: MA
authors.lastname: Ator
authors.forename: Edward R
authors.initials: ER
authors.lastname: Bacon
authors.forename: Sankar
authors.initials: S
authors.lastname: Chatterjee
mesh_terms: D000818:Animals; D001559:Benzhydryl Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D005449:Fluorenes / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D007274:Injections, Intraperitoneal; D000077408:Modafinil; D018696:Neuroprotective Agents / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics; D051381:Rats; D013454:Sulfoxides / Q000138:chemical synthesis / Q000737:chemistry* / Q000493:pharmacokinetics
chemical_list: D001559:Benzhydryl Compounds; D005449:Fluorenes; D018696:Neuroprotective Agents; D013454:Sulfoxides; C042788:fluoren-9-ol; D000077408:Modafinil