title: Developmental risk I: depression and the developing brain.
abstract: This article discusses recent findings on the neurobiology of pediatric depression as well as the interplay between genetic and environmental factors in determining the risk for the disorder. Utilizing data from both animal and human studies, the authors focus on the evolving understanding of the developmental neurobiology of emotional regulation, cognitive function and social behavior as it applies to the risk and clinical course of depression. Treatment implications and directions for future research are also discussed.
authors.affiliation: Center for Molecular and Behavioral Neuroscience, Meharry Medical College, 1005 Dr D.B. Todd Jr Boulevard, Nashville, TN 37208, USA.
authors.forename: John M
authors.initials: JM
authors.lastname: Weir
authors.forename: Arthurine
authors.initials: A
authors.lastname: Zakama
authors.forename: Uma
authors.initials: U
authors.lastname: Rao
mesh_terms: D000293:Adolescent; D000339:Affect / Q000502:physiology; D001921:Brain / Q000254:growth & development* / Q000473:pathology / Q000503:physiopathology; D001927:Brain Diseases / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D002648:Child; D003071:Cognition / Q000502:physiology; D003866:Depressive Disorder / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D002658:Developmental Disabilities / Q000503:physiopathology* / Q000523:psychology; D004644:Emotions / Q000502:physiology; D020022:Genetic Predisposition to Disease; D006801:Humans; D008279:Magnetic Resonance Imaging; D011110:Polymorphism, Genetic; D012201:Reward; D012307:Risk Factors; D012701:Serotonin / Q000502:physiology; D012919:Social Behavior; D009435:Synaptic Transmission / Q000502:physiology
chemical_list: D012701:Serotonin