title: Regional muscle glucose uptake remains elevated one week after cessation of resistance training independent of altered insulin sensitivity response in older adults with type 2 diabetes.
abstract: BACKGROUND
  Aging is associated with a decline in skeletal muscle size.Muscle is critical both for mobility and glucose disposal. While resistance exercise (RE) increases muscle mass and function in the elderly, its role in improving glucose utilization is less clear.
  
  
  OBJECTIVE
  To investigate whether muscle size was linked with insulin sensitivity (IS) in elders with diabetes following RE and if regional muscle glucose uptake differed from systemic glucose utilization.
  
  
  METHODS
  Seven (68.4 ± 5.9 yr) adults with diabetes participated. After 16 weeks of RE, within 24 h (post 1) and after 1 week of no exercise (post 2), lean tissue cross-sectional area (CSA) and IS via glucose infusion rate (GIR) were assessed along with a standardized 18-F fluorodeoxyglucose (FDG)-positron emission tomography uptake value (SUV).
  
  
  RESULTS
  CSA increased between pre-test (108.5 ± 35.3 cm2) and post 1 (116.8 ± 40.9 cm2), p=0.02 and did not differ at post 2 (116.0 ± 39.3 cm2). GIR during the 40 mU/m2/min insulin clamp differed between pretest (22.0 ± 15.8 mg/kg/min) and post 1 (67.9 ± 72.8 mg/kg/min), and post 1 and post 2 (25.0 ± 27.2 mg/kg/min) but not between pre-test and post 2. GIR results during the 200 mU/m2/min insulin clamps also differed between pre-test and post 1, and post 1 and post 2 but not between pre-test and post 2. FDG-SUV increased between pre-test (1.1 ± 0.2) and post 1 (1.4 ± 0.3), and remained stable between post 1 and post 2 (1.4 ± 0.4).
  
  
  CONCLUSIONS
  RE that increased muscle size and FDG-SUV improved IS 24 h but not 1 week after exercise training.
authors.affiliation: Department of Physical Therapy, University of Utah, 520 Wakara Way, Salt Lake City, UT 84108, USA. robin.marcus@hsc.utah.edu
authors.forename: R L
authors.initials: RL
authors.lastname: Marcus
authors.forename: O
authors.initials: O
authors.lastname: Addison
authors.forename: P C
authors.initials: PC
authors.lastname: LaStayo
authors.forename: R
authors.initials: R
authors.lastname: Hungerford
authors.forename: A R
authors.initials: AR
authors.lastname: Wende
authors.forename: J M
authors.initials: JM
authors.lastname: Hoffman
authors.forename: E D
authors.initials: ED
authors.lastname: Abel
authors.forename: D A
authors.initials: DA
authors.lastname: McClain
mesh_terms: D000368:Aged; D000375:Aging / Q000378:metabolism* / Q000502:physiology; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism* / Q000503:physiopathology / Q000628:therapy; D005260:Female; D005947:Glucose / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000378:metabolism* / Q000502:physiology; D055070:Resistance Training / Q000379:methods / Q000639:trends*; D013997:Time Factors
chemical_list: D005947:Glucose