title: Lack of an association human dioxin detoxification gene polymorphisms with endometriosis in Japanese women: results of a pilot study.
abstract: OBJECTIVE
  Endometriosis is a chronic disease caused by the presence of endometrial tissue in ectopic locations outside the uterus. Chronic exposure to the environmental pollutant dioxin has been correlated with an increased incidence in the development of endometriosis in non-human primates. We have therefore examined whether there is an association between the polymorphisms of ten dioxin detoxification genes and endometriosis in Japanese women.
  
  
  METHODS
  This was a pilot study in which 100 patients with endometriosis and 143 controls were enrolled. The prevalence of five microsatellite and 28 single nucleotide polymorphism markers within ten dioxin detoxification genes (AhR, AHRR, ARNT, CYP1A1, CYP2E1, EPHX1, GSTM1, GSTP1, GSTT1, NAT2) was examined.
  
  
  RESULTS
  Taking into account that this analysis was a preliminary study due to its small sample size and genetic power, the results did not show any statistically significant difference between the cases and controls for any of the allele and genotype frequency distributions examined. In addition, no significant associations between the allele/genotype of all polymorphisms and the stage (I-II or III-IV) of endometriosis were observed.
  
  
  CONCLUSIONS
  Based on the findings of this pilot study, we conclude the polymorphisms of the ten dioxin detoxification genes analyzed did not contribute to the etiology of endometriosis among our patients.
authors.affiliation: Division of Basic Molecular Science and Molecular Medicine, School of Medicine, Tokai University, Bohseidai, Isehara, Kanagawa, Japan. yasunari.matsuzaka@helmholtz-muenchen.de
authors.forename: Yasunari
authors.initials: Y
authors.lastname: Matsuzaka
authors.forename: Yukie Y
authors.initials: YY
authors.lastname: Kikuti
authors.forename: Kenichi
authors.initials: K
authors.lastname: Goya
authors.forename: Takahiro
authors.initials: T
authors.lastname: Suzuki
authors.forename: Li-Yi
authors.initials: LY
authors.lastname: Cai
authors.forename: Akira
authors.initials: A
authors.lastname: Oka
authors.forename: Hidetoshi
authors.initials: H
authors.lastname: Inoko
authors.forename: Jerzy K
authors.initials: JK
authors.lastname: Kulski
authors.forename: Shun-Ichiro
authors.initials: S
authors.lastname: Izumi
authors.forename: Minoru
authors.initials: M
authors.lastname: Kimura
mesh_terms: D000328:Adult; D000483:Alleles; D016022:Case-Control Studies; D004147:Dioxins / Q000378:metabolism*; D004715:Endometriosis / Q000139:chemically induced / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008658:Inactivation, Metabolic; D007564:Japan / Q000453:epidemiology; D018895:Microsatellite Repeats; D008875:Middle Aged; D010865:Pilot Projects; D011110:Polymorphism, Genetic; D020641:Polymorphism, Single Nucleotide
chemical_list: D004147:Dioxins