title: p53 and p73 expression in esophageal carcinoma correlate with clinicopathology of tumors.
abstract: OBJECTIVE
  Inactivation of tumor suppressors like p53 and p73 plays an important role in cancer initiation. We explored the clinical significance of p53 and p73 expression in esophageal carcinoma, along with their correlation with clinicopathological parameters of tumors for potential use in clinical evaluation of this disease.
  
  
  METHODS
  In the present study, tumor samples and adjacent normal tissue samples were collected from 37 patients with esophageal cancer and the expression of p53 and p73 was detected by immunohistochemistry and correlated with clinicopathological parameters of tumors.
  
  
  RESULTS
  p53 and p73 were more frequently expressed in esophageal cancer than in adjacent normal tissue. Indeed, there was a positive correlation between p53 and p73 expression and esophageal cancer (p<0.05). Analysis of clinicopathological features revealed that p53 expression was correlated with differentiation, distant metastases, and TNM stage (p<0.05) of tumors, but not with gender; age, infiltration depth, tumor size, or lymph node metastasis. In contrast, p73 expression was correlated only with distant metastases (p<0.05).
  
  
  CONCLUSIONS
  Increased expression of p53 and p73 in esophageal carcinoma may serve as an indicator of tumor severity. Detection of these proteins in future studies may help understand the mechanisms of development, invasion and metastasis in esophageal cancer.
authors.affiliation: Department of Oncology, Xinhua Hospital of Huainan City, Huainan, China.
authors.forename: Bing
authors.initials: B
authors.lastname: Ye
authors.forename: Xuefeng
authors.initials: X
authors.lastname: Wang
authors.forename: Zhenzhong
authors.initials: Z
authors.lastname: Yang
authors.forename: Zhengping
authors.initials: Z
authors.lastname: Sun
authors.forename: Rongbo
authors.initials: R
authors.lastname: Zhang
authors.forename: Youying
authors.initials: Y
authors.lastname: Hu
authors.forename: Youguo
authors.initials: Y
authors.lastname: Lu
authors.forename: Jiuwei
authors.initials: J
authors.lastname: Du
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D002277:Carcinoma / Q000737:chemistry* / Q000473:pathology*; D002454:Cell Differentiation; D016009:Chi-Square Distribution; D004268:DNA-Binding Proteins / Q000032:analysis*; D004938:Esophageal Neoplasms / Q000737:chemistry* / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D009687:Nuclear Proteins / Q000032:analysis*; D011379:Prognosis; D000072160:Tumor Protein p73; D016159:Tumor Suppressor Protein p53 / Q000032:analysis*; D025521:Tumor Suppressor Proteins / Q000032:analysis*; D015854:Up-Regulation
chemical_list: D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; C495901:TP53 protein, human; C000606460:TP73 protein, human; D000072160:Tumor Protein p73; D016159:Tumor Suppressor Protein p53; D025521:Tumor Suppressor Proteins