title: Potential quantitative magnetic resonance imaging biomarkers of coronary remodeling in older hypertensive patients.
abstract: OBJECTIVE
  To detect differences in potential magnetic resonance imaging biomarkers of coronary remodeling between older hypertensive patients and healthy controls.
  
  
  RESULTS
  Two-dimensional black-blood coronary wall magnetic resonance imaging and 3-dimensional whole-heart coronary magnetic resonance angiography were performed on 130 participants (65-84 years), including 65 hypertensive patients and 65 healthy controls. Coronary segments derived from hypertensive participants had a higher mean coronary wall thickness, a smaller vessel area, a smaller coronary wall area, a smaller lumen area, a lower coronary distensibility index, and a higher percent of the coronary wall occupying the vessel area (PWOV) than those from healthy controls. When the average PWOV was set as an ad hoc cutoff point, coronary segments with a high PWOV had a significantly higher mean wall thickness, a higher maximum wall thickness, a smaller vessel area, a smaller lumen area, a lower coronary distensibility index, and a higher coronary plaque index compared with coronary segments with a low PWOV.
  
  
  CONCLUSIONS
  Magnetic resonance techniques are able to noninvasively detect significant differences in potential imaging biomarkers of coronary remodeling between older hypertensive patients and healthy controls. The PWOV is a promising remodeling feature for quantitatively evaluating the progression of coronary atherosclerosis.
authors.affiliation: Department of Radiology, Northwestern University, Chicago, IL 60611, USA. kai-lin@northwestern.edu
authors.forename: Kai
authors.initials: K
authors.lastname: Lin
authors.forename: Donald M
authors.initials: DM
authors.lastname: Lloyd-Jones
authors.forename: Ying
authors.initials: Y
authors.lastname: Liu
authors.forename: Xiaoming
authors.initials: X
authors.lastname: Bi
authors.forename: Debiao
authors.initials: D
authors.lastname: Li
authors.forename: James C
authors.initials: JC
authors.lastname: Carr
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D003324:Coronary Artery Disease / Q000175:diagnosis*; D003331:Coronary Vessels / Q000473:pathology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male
chemical_list: D015415:Biomarkers